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DerHautarzt.60470355.eng.abstr
|
DerHautarzt.60470355.eng.abstr
|
[
{
"id": "DerHautarzt.60470355.eng.abstr-passage-0",
"type": "abstract",
"text": [
"No adequate topical therapy is available for pruritus . As little is known about the local influence of antihistamines and topical anaesthetics on the pruritic effect of histamine , we studied these agents in 12 volunteers . The antipruritic effect of 15-min topical application of dimethindene maleate ( Fenistil gel ) and different agents ( Optiderm , EMLA , Xylocaine-Salbe 5% ) on subsequent focal histamine stimulus ( 20 mC ) given by iontophoresis was evaluated . The results were compared with those of pretreatment with the corresponding placebo creams and observations on skin . Wheal and flare areas were evaluated planimetrically . Itch or pain ratings were entered on a scale every minute over a 24-min period . The examination also comprised alloknesis , i.e. elicitation of perifocal itch sensation by usually non-itch-inducing ( e.g. mechanical ) stimuli . Remarkably , all topically applied substances , regardless of antihistaminic or anaesthetic potential , reduced the area of alloknesis significantly . This is likely to be a result of diminished excitability of the cutaneous mechanoreceptors . Itching was significantly reduced by all active substances , including the placebo cream corresponding to Optiderm , which might be due to the presence of urea ."
],
"offsets": [
[
0,
1277
]
]
}
] |
[
{
"id": "DerHautarzt.60470355.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"therapy"
],
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20,
27
]
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"db_id": "C0087111"
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{
"db_name": "UMLS",
"db_id": "C0039798"
}
]
},
{
"id": "DerHautarzt.60470355.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"pruritus"
],
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[
45,
53
]
],
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"db_name": "UMLS",
"db_id": "C0033778"
},
{
"db_name": "UMLS",
"db_id": "C0033774"
}
]
},
{
"id": "DerHautarzt.60470355.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"antihistamines"
],
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[
104,
118
]
],
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"db_name": "UMLS",
"db_id": "C0003360"
}
]
},
{
"id": "DerHautarzt.60470355.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"anaesthetics"
],
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131,
143
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],
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"db_id": "C0002932"
}
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},
{
"id": "DerHautarzt.60470355.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"histamine"
],
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170,
179
]
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"db_id": "C0019588"
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{
"id": "DerHautarzt.60470355.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"volunteers"
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[
212,
222
]
],
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"db_name": "UMLS",
"db_id": "C0042960"
}
]
},
{
"id": "DerHautarzt.60470355.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"antipruritic"
],
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229,
241
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],
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"db_name": "UMLS",
"db_id": "C0003417"
}
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},
{
"id": "DerHautarzt.60470355.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"maleate"
],
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295,
302
]
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"db_id": "C0220874"
},
{
"db_name": "UMLS",
"db_id": "C0024572"
}
]
},
{
"id": "DerHautarzt.60470355.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"Fenistil"
],
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[
305,
313
]
],
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{
"db_name": "UMLS",
"db_id": "C0016562"
}
]
},
{
"id": "DerHautarzt.60470355.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"gel"
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[
314,
317
]
],
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{
"db_name": "UMLS",
"db_id": "C0017243"
}
]
},
{
"id": "DerHautarzt.60470355.eng.abstr-s3-t5",
"type": "umlsterm",
"text": [
"EMLA"
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354,
358
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"db_id": "C0059079"
}
]
},
{
"id": "DerHautarzt.60470355.eng.abstr-s3-t6",
"type": "umlsterm",
"text": [
"histamine"
],
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[
402,
411
]
],
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{
"db_name": "UMLS",
"db_id": "C0019588"
}
]
},
{
"id": "DerHautarzt.60470355.eng.abstr-s3-t7",
"type": "umlsterm",
"text": [
"iontophoresis"
],
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[
440,
453
]
],
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{
"db_name": "UMLS",
"db_id": "C0022024"
}
]
},
{
"id": "DerHautarzt.60470355.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"placebo"
],
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[
546,
553
]
],
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{
"db_name": "UMLS",
"db_id": "C0032042"
}
]
},
{
"id": "DerHautarzt.60470355.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"observations"
],
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[
565,
577
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0302523"
}
]
},
{
"id": "DerHautarzt.60470355.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"skin"
],
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[
581,
585
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.60470355.eng.abstr-s6-t1",
"type": "umlsterm",
"text": [
"Itch"
],
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[
643,
647
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0033774"
}
]
},
{
"id": "DerHautarzt.60470355.eng.abstr-s6-t2",
"type": "umlsterm",
"text": [
"pain"
],
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[
651,
655
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030193"
}
]
},
{
"id": "DerHautarzt.60470355.eng.abstr-s6-t3",
"type": "umlsterm",
"text": [
"scale"
],
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[
682,
687
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0175659"
}
]
},
{
"id": "DerHautarzt.60470355.eng.abstr-s6-t4",
"type": "umlsterm",
"text": [
"period"
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[
715,
721
]
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"normalized": [
{
"db_name": "UMLS",
"db_id": "C0025344"
}
]
},
{
"id": "DerHautarzt.60470355.eng.abstr-s7-t1",
"type": "umlsterm",
"text": [
"itch"
],
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[
798,
802
]
],
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}
]
},
{
"id": "DerHautarzt.60470355.eng.abstr-s7-t2",
"type": "umlsterm",
"text": [
"sensation"
],
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[
803,
812
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"db_name": "UMLS",
"db_id": "C0036658"
}
]
},
{
"id": "DerHautarzt.60470355.eng.abstr-s8-t1",
"type": "umlsterm",
"text": [
"antihistaminic"
],
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[
934,
948
]
],
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"db_id": "C0003209"
},
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"db_name": "UMLS",
"db_id": "C0003204"
}
]
},
{
"id": "DerHautarzt.60470355.eng.abstr-s8-t2",
"type": "umlsterm",
"text": [
"anaesthetic"
],
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952,
963
]
],
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"db_name": "UMLS",
"db_id": "C0002932"
}
]
},
{
"id": "DerHautarzt.60470355.eng.abstr-s9-t1",
"type": "umlsterm",
"text": [
"mechanoreceptors"
],
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[
1097,
1113
]
],
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{
"db_name": "UMLS",
"db_id": "C0025032"
}
]
},
{
"id": "DerHautarzt.60470355.eng.abstr-s10-t1",
"type": "umlsterm",
"text": [
"Itching"
],
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1116,
1123
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"db_name": "UMLS",
"db_id": "C0033774"
}
]
},
{
"id": "DerHautarzt.60470355.eng.abstr-s10-t2",
"type": "umlsterm",
"text": [
"placebo"
],
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[
1191,
1198
]
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{
"db_name": "UMLS",
"db_id": "C0032042"
}
]
},
{
"id": "DerHautarzt.60470355.eng.abstr-s10-t3",
"type": "umlsterm",
"text": [
"urea"
],
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[
1271,
1275
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0041942"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.60470355.eng.abstr-s1-r1-t1.1-t2.2",
"type": "treats",
"arg1_id": "DerHautarzt.60470355.eng.abstr-s10-t1",
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"normalized": []
},
{
"id": "DerHautarzt.60470355.eng.abstr-s1-r2-t1.1-t2.2",
"type": "associated_with",
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"normalized": []
},
{
"id": "DerHautarzt.60470355.eng.abstr-s1-r3-t2.2-t1.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.60470355.eng.abstr-s3-t2",
"arg2_id": "DerHautarzt.60470355.eng.abstr-s10-t1",
"normalized": []
},
{
"id": "DerHautarzt.60470355.eng.abstr-s2-r1-t3.1-t1.1",
"type": "interacts_with",
"arg1_id": "DerHautarzt.60470355.eng.abstr-s10-t3",
"arg2_id": "DerHautarzt.60470355.eng.abstr-s10-t1",
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},
{
"id": "DerHautarzt.60470355.eng.abstr-s2-r2-t1.1-t3.1",
"type": "interacts_with",
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"arg2_id": "DerHautarzt.60470355.eng.abstr-s10-t3",
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},
{
"id": "DerHautarzt.60470355.eng.abstr-s3-r1-t7.1-t3.1",
"type": "uses",
"arg1_id": "DerHautarzt.60470355.eng.abstr-s3-t7",
"arg2_id": "DerHautarzt.60470355.eng.abstr-s10-t3",
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},
{
"id": "DerHautarzt.60470355.eng.abstr-s3-r2-t3.1-t2.1",
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{
"id": "DerHautarzt.60470355.eng.abstr-s3-r3-t5.1-t3.1",
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},
{
"id": "DerHautarzt.60470355.eng.abstr-s3-r4-t7.1-t5.1",
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},
{
"id": "DerHautarzt.60470355.eng.abstr-s3-r5-t3.1-t1.1",
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},
{
"id": "DerHautarzt.60470355.eng.abstr-s3-r6-t5.1-t2.1",
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{
"id": "DerHautarzt.60470355.eng.abstr-s3-r7-t7.1-t1.1",
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},
{
"id": "DerHautarzt.60470355.eng.abstr-s3-r8-t3.1-t5.1",
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},
{
"id": "DerHautarzt.60470355.eng.abstr-s3-r9-t5.1-t1.1",
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},
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"id": "DerHautarzt.60470355.eng.abstr-s4-r1-t2.1-t3.1",
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},
{
"id": "DerHautarzt.60470355.eng.abstr-s6-r1-t1.1-t3.1",
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},
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"id": "DerHautarzt.60470355.eng.abstr-s6-r2-t2.1-t3.1",
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},
{
"id": "DerHautarzt.60470355.eng.abstr-s7-r1-t1.1-t2.1",
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},
{
"id": "DerHautarzt.60470355.eng.abstr-s10-r1-t2.1-t1.1",
"type": "treats",
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},
{
"id": "DerHautarzt.60470355.eng.abstr-s10-r2-t3.1-t1.1",
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}
] |
DerHautarzt.60470361.eng.abstr
|
DerHautarzt.60470361.eng.abstr
|
[
{
"id": "DerHautarzt.60470361.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Small vessels with luminal diameters of 0.2-2.0 mm have not been studied with routine ultrasound diagnostic procedures . Modern color Doppler imaging technology , however , should allow visualization of the blood flow even in such small vessels . The present study was therefore aimed at demonstrating the possibilities of examining small arteries in the fingertips of healthy volunteers with color Doppler imaging . The question was whether or not a standardized visualization was possible . We found that small arteries and their blood flow could be demonstrated in all ( n=10) healthy subjects . Furthermore , we demonstrated pathologic findings in the fingertip arteries of a patient with thrombangiitis obliterans as an example of the diagnostic value of these new procedures ."
],
"offsets": [
[
0,
782
]
]
}
] |
[
{
"id": "DerHautarzt.60470361.eng.abstr-s1-t1",
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"vessels"
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6,
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{
"id": "DerHautarzt.60470361.eng.abstr-s1-t2",
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"ultrasound"
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86,
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{
"db_name": "UMLS",
"db_id": "C0041621"
}
]
},
{
"id": "DerHautarzt.60470361.eng.abstr-s1-t3",
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"diagnostic"
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97,
107
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"db_id": "C0348026"
}
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},
{
"id": "DerHautarzt.60470361.eng.abstr-s1-t4",
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"procedures"
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"db_id": "C0025664"
}
]
},
{
"id": "DerHautarzt.60470361.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"color"
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[
128,
133
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{
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}
]
},
{
"id": "DerHautarzt.60470361.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"imaging"
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142,
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]
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},
{
"id": "DerHautarzt.60470361.eng.abstr-s2-t3",
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"technology"
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150,
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],
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"db_id": "C0039421"
}
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},
{
"id": "DerHautarzt.60470361.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"visualization"
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186,
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],
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"db_id": "C0150627"
}
]
},
{
"id": "DerHautarzt.60470361.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"blood"
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207,
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]
],
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{
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"db_id": "C0005767"
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{
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},
{
"db_name": "UMLS",
"db_id": "C0005835"
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]
},
{
"id": "DerHautarzt.60470361.eng.abstr-s2-t6",
"type": "umlsterm",
"text": [
"vessels"
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237,
244
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],
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[] |
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] |
DerHautarzt.60470365.eng.abstr
|
DerHautarzt.60470365.eng.abstr
|
[
{
"id": "DerHautarzt.60470365.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Infections with parvovirus B19 are often characterized by the well-known erythema infectiosum , usually accompanied by fever and arthralgia . Furthermore the virus may cause a lethal hydrops fetalis during the pregnancy or a severe aplastic crisis in patients suffer from chronic hemolytic anemia . We present three patients infected by parvovirus B19. Whose skin lesions included a non-specific exanthem , erythema multiforme , and purpura . The virus infection was confirmed both by serology and PCR identification . In conclusion the diagnosis of acute exanthems should include the search for virus infections ."
],
"offsets": [
[
0,
614
]
]
}
] |
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10
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{
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"parvovirus"
],
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26
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{
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],
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73,
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]
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{
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"fever"
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] |
DerHautarzt.60470378.eng.abstr
|
DerHautarzt.60470378.eng.abstr
|
[
{
"id": "DerHautarzt.60470378.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Eruptive vellus hair cysts are rare epidermal cysts with vellus hairs , which appear in children or young adults . A 21-year-old patient is reported who developed asymptomatic comedo-like papules on his face , neck and chest . Histopathologically , epidermoid cysts with a fine stratum granulosum , laminated keratinous material and numerous vellus hairs were found in the mid-dermis . Evaluation of immediate family members revealed that the patient's father was similarly affected . Eruptive vellus hair cysts and steatocystoma multiplex are clinically similar , but have distinctive histopathological features and should be regarded as distinct entities ."
],
"offsets": [
[
0,
658
]
]
}
] |
[
{
"id": "DerHautarzt.60470378.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"hair"
],
"offsets": [
[
16,
20
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018494"
}
]
},
{
"id": "DerHautarzt.60470378.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"cysts"
],
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[
21,
26
]
],
"normalized": [
{
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"db_id": "C0010709"
}
]
},
{
"id": "DerHautarzt.60470378.eng.abstr-s1-t3",
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"text": [
"cysts"
],
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[
46,
51
]
],
"normalized": [
{
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"db_id": "C0010709"
}
]
},
{
"id": "DerHautarzt.60470378.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"hairs"
],
"offsets": [
[
64,
69
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018494"
}
]
},
{
"id": "DerHautarzt.60470378.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"children"
],
"offsets": [
[
88,
96
]
],
"normalized": [
{
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"db_id": "C0008059"
}
]
},
{
"id": "DerHautarzt.60470378.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"adults"
],
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[
106,
112
]
],
"normalized": [
{
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"db_id": "C0001675"
}
]
},
{
"id": "DerHautarzt.60470378.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"epidermal cysts"
],
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[
36,
51
]
],
"normalized": [
{
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"db_id": "C0014511"
}
]
},
{
"id": "DerHautarzt.60470378.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"patient"
],
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[
129,
136
]
],
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{
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"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.60470378.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"face"
],
"offsets": [
[
203,
207
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0015450"
}
]
},
{
"id": "DerHautarzt.60470378.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"neck"
],
"offsets": [
[
210,
214
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027530"
}
]
},
{
"id": "DerHautarzt.60470378.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"chest"
],
"offsets": [
[
219,
224
]
],
"normalized": [
{
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"db_id": "C0039992"
}
]
},
{
"id": "DerHautarzt.60470378.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"cysts"
],
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[
260,
265
]
],
"normalized": [
{
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"db_id": "C0010709"
}
]
},
{
"id": "DerHautarzt.60470378.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"hairs"
],
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[
349,
354
]
],
"normalized": [
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}
]
},
{
"id": "DerHautarzt.60470378.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"mid-dermis"
],
"offsets": [
[
373,
383
]
],
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"db_id": "C0011646"
}
]
},
{
"id": "DerHautarzt.60470378.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"epidermoid cysts"
],
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[
249,
265
]
],
"normalized": [
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"db_id": "C0014511"
}
]
},
{
"id": "DerHautarzt.60470378.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"Evaluation"
],
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[
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396
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],
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"db_id": "C0220825"
}
]
},
{
"id": "DerHautarzt.60470378.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"family"
],
"offsets": [
[
410,
416
]
],
"normalized": [
{
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"db_id": "C0015576"
}
]
},
{
"id": "DerHautarzt.60470378.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"father"
],
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[
453,
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]
],
"normalized": [
{
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}
]
},
{
"id": "DerHautarzt.60470378.eng.abstr-s4-t4",
"type": "umlsterm",
"text": [
"family members"
],
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[
410,
424
]
],
"normalized": [
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]
},
{
"id": "DerHautarzt.60470378.eng.abstr-s5-t1",
"type": "umlsterm",
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"hair"
],
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],
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},
{
"id": "DerHautarzt.60470378.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
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],
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],
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}
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},
{
"id": "DerHautarzt.60470378.eng.abstr-s5-t3",
"type": "umlsterm",
"text": [
"steatocystoma"
],
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]
],
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},
{
"id": "DerHautarzt.60470378.eng.abstr-s5-t4",
"type": "umlsterm",
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[
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]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0243140"
}
]
}
] |
[] |
[] |
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] |
DerHautarzt.60470382.eng.abstr
|
DerHautarzt.60470382.eng.abstr
|
[
{
"id": "DerHautarzt.60470382.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 25-year-old carpenter with severe localised Raynaud syndrome of the lateral three fingers of his right hand is described . The patient reported digital ischaemia caused by cold or vibration , and especially when both were present simultaneously . He was initially diagnosed with thrombangitis obliterans , but failed to respond to intravenous prostaglandin therapy , pentoxifyllin or aspirin . Diagnostic procedures performed in our hospital , especially angiography , confirmed our suspicion of hypothenar hammer syndrome . Radiological examination revealed severe anatomical and functional changes of the distal ulnar artery and , digital arteries of the affected digits . The differential diagnosis of Raynaud syndrome should include the hypothenar hammer syndrome as a possible cause . Early diagnosis and prevention of hand trauma is the only possible way to stop progression of this disease , which leads to invalidity ."
],
"offsets": [
[
0,
928
]
]
}
] |
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] |
[] |
[] |
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] |
DerHautarzt.60470387.eng.abstr
|
DerHautarzt.60470387.eng.abstr
|
[
{
"id": "DerHautarzt.60470387.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Plaque-like glomus tumours are an unusual and very rare clinical form of multiple regional glomus tumours . We report on a 16-year-old girl with this variety of glomus tumours . The irregular angiomatous plaques localized on her back and right hip were present from birth and enlarged with body growth . In addition , there were some bluish nodules scattered on the right mamma , the abdomen and the left shoulder . The family history showed hereditary influences . The proper diagnosis was based on histological and immunohistochemical findings . In the present case report , the clinical , histopathological and immunohistochemical features and the differential diagnosis of multiple plaque-like glomus tumours are discussed ."
],
"offsets": [
[
0,
728
]
]
}
] |
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0,
11
]
],
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"db_id": "C0011389"
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}
]
},
{
"id": "DerHautarzt.60470387.eng.abstr-s1-t2",
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"tumours"
],
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19,
26
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],
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"tumours"
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168,
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{
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},
{
"id": "DerHautarzt.60470387.eng.abstr-s3-t1",
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},
{
"id": "DerHautarzt.60470387.eng.abstr-s3-t2",
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"back"
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229,
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]
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{
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},
{
"id": "DerHautarzt.60470387.eng.abstr-s3-t4",
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},
{
"id": "DerHautarzt.60470387.eng.abstr-s4-t1",
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DerHautarzt.60470417.eng.abstr
|
DerHautarzt.60470417.eng.abstr
|
[
{
"id": "DerHautarzt.60470417.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Human skin is exposed to a great deal of environmental stimulation , which in predisposed individuals may cause specific inflammatory dermatosis . Typically , endothelial activation can be observed as the induced expression of cell adhesion molecules . This allows circulating immune cells to adhere to the endothelium and results in inflammatory , perivascular cell infiltrates in the affected tissue area . While tissue-derived cytokines have been discussed primarily as controlling factors of these inflammatory processes , recent evidence suggests direct endothelial activation by various exogenous impulses . Endothelial adhesion molecule expression has been found to be exclusively responsive to biochemical or biophysical stimulation , such as the concentration of metal ions , oxygen tension , UV radiationor mechanically operating shear stress without appreciable interaction of cytokines . These observations indicate that endothelial cells are capable of responding to exogenous stimulation , or rather transduce both exogenous and endogenous impulses , resulting in an integrative process . In view of this , individual deviations of endothelial cell functions need to be considered in pathophysiological concepts about diseases caused by external provocation , while their clinical relevance must be evaluated ."
],
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[
0,
1324
]
]
}
] |
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] |
[] |
[] |
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] |
DerHautarzt.60470422.eng.abstr
|
DerHautarzt.60470422.eng.abstr
|
[
{
"id": "DerHautarzt.60470422.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Enlargement of the male mammary gland is termed gynaecomastia . Diagnosis and treatment of this andrological disorder usually fall to dermatologists , surgeons and primary care physicians . Gynaecomastia is found in men of different ages with frequency . The harmless pubertal gynaecomastia is as frequent as gynaecomastia of the elderly . Other forms are caused by an altered ratio of oestrogens to androgens , by hCG-producing tumours , and by hyperprolactinaemia . There is no correlation between cause and clinical appearance . Gynaecomastia is easy usually easily diagnosed by clinical examination ; sonography and mammography may then be used for confirmation . Endocrine causes and hCG-producing tumours should be excluded by hormone analysis . Histological examination of the tissue is mandatory to exclude carcinoma of the breast . The prognosis of male breast carcinoma is not poorer than that of the female carcinoma . Pubertal gynaecomastia usually resolves spontaneously . Surgical removal is generally required in other forms , as conservative approaches are ineffective ."
],
"offsets": [
[
0,
1086
]
]
}
] |
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"id": "DerHautarzt.60470422.eng.abstr-s1-t2",
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"male"
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}
]
},
{
"id": "DerHautarzt.60470422.eng.abstr-s1-t3",
"type": "umlsterm",
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"gynaecomastia"
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},
{
"id": "DerHautarzt.60470422.eng.abstr-s1-t4",
"type": "umlsterm",
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"mammary gland"
],
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24,
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"id": "DerHautarzt.60470422.eng.abstr-s2-t1",
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"Diagnosis"
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"id": "DerHautarzt.60470422.eng.abstr-s2-t2",
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"treatment"
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"id": "DerHautarzt.60470422.eng.abstr-s2-t3",
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"care"
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"physicians"
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"id": "DerHautarzt.60470422.eng.abstr-s3-t1",
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"id": "DerHautarzt.60470422.eng.abstr-s3-t2",
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"men"
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"id": "DerHautarzt.60470422.eng.abstr-s3-t3",
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"id": "DerHautarzt.60470422.eng.abstr-s3-t4",
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"id": "DerHautarzt.60470422.eng.abstr-s3-t5",
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"id": "DerHautarzt.60470422.eng.abstr-s4-t1",
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"id": "DerHautarzt.60470422.eng.abstr-s4-t3",
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] |
[] |
[] |
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DerHautarzt.60470427.eng.abstr
|
DerHautarzt.60470427.eng.abstr
|
[
{
"id": "DerHautarzt.60470427.eng.abstr-passage-0",
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"text": [
"Psoriasis is a generalized disease that affects bone as well as skin . Three patterns of bone involvement can be differentiated in psoriatic arthritis distal , central , and distal combined with central . Distal involvement is more specific for psoriatic arthritis , with radial and/or transverse involvement of the distal interphalangeal joints . The progression dynamic and the pattern of distribution are different from those pattern of rheumatoid arthritis : psoriatic arthritis originates in the periarticular bone and extends towards the synovia , whereas in rheumatoid arthritis it extends in the opposite direction . In psoriatic arthritis anterior chest wall syndrome , insertion tendinopathies , and localized or diffuse bone disease are often observed . Bone scintigraphy is more sensitive in the diagnosis of psoriatic bone involvement than clinical examination or conventional radiological imaging , allowing earlier diagnosis through the visualization and documentation of specific patterns and presence of disease in multiple sites . It also allows more discriminating selection of subsequent X-ray examinations to limit radiation exposure . Thus , bone scintigraphy is now the most important diagnostic tool in the assessment of psoriatic arthritis ."
],
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[] |
[] |
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DerHautarzt.60470432.eng.abstr
|
DerHautarzt.60470432.eng.abstr
|
[
{
"id": "DerHautarzt.60470432.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 72-years old man with Parkinson's disease was treated with levodopa for 14 years . A superficial spreading melanoma ( Breslow depth 1,8 mm , Clark level IV ) was diagnosed , developing on the back from a pigment lesion which had present for more than 10 years . Other case reports suggest a relationship between the administration of levodopa and the growth of malignant melanoma . On the other hand , epidemiological studies found no correlation . Furthermore , in vitro and in vivo studies have shown a possible anti-tumor effect of levodopa . Critical analysis of the literature leads to the conclusion , that there is no increased melanoma risk from levodopa ."
],
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[
0,
666
]
]
}
] |
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"id": "DerHautarzt.60470432.eng.abstr-s1-t1",
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"id": "DerHautarzt.60470432.eng.abstr-s2-t1",
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{
"id": "DerHautarzt.60470432.eng.abstr-s2-t2",
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"id": "DerHautarzt.60470432.eng.abstr-s3-t2",
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"id": "DerHautarzt.60470432.eng.abstr-s3-t4",
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] |
[] |
[] |
[
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{
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},
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},
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},
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}
] |
DerHautarzt.60470438.eng.abstr
|
DerHautarzt.60470438.eng.abstr
|
[
{
"id": "DerHautarzt.60470438.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We treated a large superficial basal cell carcinoma ( ca. 10x6 cm ) on the right breast in a 48-year old woman with photodynamic terapy ( PDT ) . Fractionated PDT was performed by topical application of -aminolevulinic acid ( -ALA , 20% ) with subsequent red light ( 570-750 nm ; 180 J/cm2) in three sessions . Nearly total remission of the tumor resulted ; however , a few residual neoplastic islands partly infiltrating the nipple-areola complex could be detected by photodynamic diagnosis ( PDD ) . These fluorescent areas were marked , excised , and the defect was closed by a rotation advancement flap . Total excision of the tumor was verified histologically . By combining PDT and surgery , this large tumor was treated with excellent cosmetic results . This case demonstrates the efficiency of topical PDT with adjunctive plastic surgery controlled by PDD even in large tumors ."
],
"offsets": [
[
0,
886
]
]
}
] |
[
{
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{
"id": "DerHautarzt.60470438.eng.abstr-s1-t2",
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"carcinoma"
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{
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{
"id": "DerHautarzt.60470438.eng.abstr-s1-t4",
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"breast"
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] |
DerHautarzt.60470447.eng.abstr
|
DerHautarzt.60470447.eng.abstr
|
[
{
"id": "DerHautarzt.60470447.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Clinical and histopathological findings of 34 cases of desmoplastic malignant melanoma ( DMM ) are summarized and compared to the literature . DMM develop mostly in sun damaged skin of elderly patients , they are rare and often nonpigmented tumors that are difficult to diagnose clinically . In all cases the tumor parameters showed level IV or V melanomas ( level IV : 55,9% , level IV-V : 14.7% , level V : 29,4% ) and the tumor thickness measured 3,85 mm +/- 2,31 mm ( 1,0-11,0 mm ) . In 22 cases , the follow-up time was between 2 and 7 years . Local recurrences were observed in 7 ( =31 , 8% ) patients , metastases in 4 ( =18 , 2% ) and tumor-related deaths in 3. The prognosis for our patients seems to be slightly better than that described in the literature . The main reason is an improved histological diagnosis of this special type of melanoma . Using immunohistochemical staining with anti-S100 antibody it is possible to establish the melanocytic nature of these fibrotic spindle cell tumors earlier that is , in small initial biopsies , and tumor margins can be defined more accurately . As a consequence , surgery is done earlier and is more likely to be curative ."
],
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}
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DerHautarzt.60470459.eng.abstr
|
DerHautarzt.60470459.eng.abstr
|
[
{
"id": "DerHautarzt.60470459.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The increasing promotion of herbal drugs may lead to allergic problems . A case of systemic contact-type dermatitis after oral administration of kava extract illustrates this special problem . The kava plant is a member of the black pepper family ; an intoxicant beverage prepared from the roots of this plant is used ceremonially by many traditional societies of the Southern Pacific . The beverage induces relaxation , enhances a sense of sociability and promotes sleep . These effects are utilized in herbal drugs containing kava , which are sold for insomnia , nervousness and depression . The ichthyosiform kava dermopathy is a well-known side effect of excessive use of kava ; in this case report we describe an acute allergic side-effect of kava extract ."
],
"offsets": [
[
0,
762
]
]
}
] |
[
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]
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DerHautarzt.60470462.eng.abstr
|
DerHautarzt.60470462.eng.abstr
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}
] |
DerHautarzt.60470465.eng.abstr
|
DerHautarzt.60470465.eng.abstr
|
[
{
"id": "DerHautarzt.60470465.eng.abstr-passage-0",
"type": "abstract",
"text": [
"PUVA-induced acrobullous dermatosis is characterized by the occurrence of blisters on the acral extremities during PUVA therapy . The tense blisters apparently arise as a result of PUVA damage to the epidermodermal cohesion coupled with friction or trauma . They must be distinguished from phototoxic reactions induced either by UVA overdosage or excessive psoralen uptake . We report on , two cases of acrobullous PUVA-induced dermatosis , discussing clinical features , pathophysiological aspects and differential diagnosis ."
],
"offsets": [
[
0,
527
]
]
}
] |
[
{
"id": "DerHautarzt.60470465.eng.abstr-s1-t1",
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"dermatosis"
],
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25,
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]
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}
]
},
{
"id": "DerHautarzt.60470465.eng.abstr-s1-t2",
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"occurrence"
],
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60,
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]
],
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"db_id": "C0243132"
}
]
},
{
"id": "DerHautarzt.60470465.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"blisters"
],
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[
74,
82
]
],
"normalized": [
{
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"db_id": "C0005758"
}
]
},
{
"id": "DerHautarzt.60470465.eng.abstr-s1-t4",
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"text": [
"extremities"
],
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[
96,
107
]
],
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{
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"db_id": "C0015385"
}
]
},
{
"id": "DerHautarzt.60470465.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"therapy"
],
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120,
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"db_id": "C0087111"
},
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}
]
},
{
"id": "DerHautarzt.60470465.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"PUVA therapy"
],
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[
115,
127
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],
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"db_id": "C0034172"
}
]
},
{
"id": "DerHautarzt.60470465.eng.abstr-s2-t1",
"type": "umlsterm",
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"blisters"
],
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140,
148
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]
},
{
"id": "DerHautarzt.60470465.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
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],
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237,
245
]
],
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}
]
},
{
"id": "DerHautarzt.60470465.eng.abstr-s2-t3",
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"text": [
"trauma"
],
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249,
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]
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"db_id": "C0021501"
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}
]
},
{
"id": "DerHautarzt.60470465.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"psoralen"
],
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[
357,
365
]
],
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}
]
},
{
"id": "DerHautarzt.60470465.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
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],
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290,
310
]
],
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]
},
{
"id": "DerHautarzt.60470465.eng.abstr-s4-t1",
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],
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428,
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]
],
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}
]
},
{
"id": "DerHautarzt.60470465.eng.abstr-s4-t2",
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],
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],
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}
]
},
{
"id": "DerHautarzt.60470465.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
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],
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503,
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"db_id": "C0220820"
},
{
"db_name": "UMLS",
"db_id": "C0011906"
}
]
}
] |
[] |
[] |
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{
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{
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},
{
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},
{
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},
{
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},
{
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"type": "associated_with",
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},
{
"id": "DerHautarzt.60470465.eng.abstr-s2-r4-t3.1-t1.1",
"type": "co-occurs_with",
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},
{
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},
{
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},
{
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{
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},
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},
{
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},
{
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},
{
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},
{
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}
] |
DerHautarzt.60470469.eng.abstr
|
DerHautarzt.60470469.eng.abstr
|
[
{
"id": "DerHautarzt.60470469.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 24-year-old woman from Peru presented with multiple dark-blue skin lesions . The asymptomatic cystic nodules had increased in number and size over the post 7 years . They were found on the abdomen and back . When one of the cysts was punctured a bunch of vellus hairs was observed . The diagnosis of steatocystoma multiplex was confirmed by histology . The patient denied that any other family member had similar problems ."
],
"offsets": [
[
0,
425
]
]
}
] |
[
{
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"woman"
],
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14,
19
]
],
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"db_id": "C0043210"
}
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},
{
"id": "DerHautarzt.60470469.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"Peru"
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25,
29
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],
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},
{
"id": "DerHautarzt.60470469.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"skin"
],
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[
64,
68
]
],
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{
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}
]
},
{
"id": "DerHautarzt.60470469.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"abdomen"
],
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[
191,
198
]
],
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{
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"db_id": "C0000726"
}
]
},
{
"id": "DerHautarzt.60470469.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"cysts"
],
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226,
231
]
],
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{
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[] |
[] |
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DerHautarzt.60470493.eng.abstr
|
DerHautarzt.60470493.eng.abstr
|
[
{
"id": "DerHautarzt.60470493.eng.abstr-passage-0",
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"text": [
"Dermatologic disorders of the stump in patients with a leg amputation may have characteristic pathophysiologic and clinical features . A knowledge of these factors may lead to earlier diagnosis and avoid immobilization . There ist no German language review of this aspect of dermatology . After providing an overview of the problem , including a discussion of prostheses , we review the following problems : mechanically induced blisters , follicular keratoses , epidermoid cysts , stump edema syndrome , acroangiodermatitis ( pseudo-kaposi sarcoma ) and verrucous hyperplasia ."
],
"offsets": [
[
0,
578
]
]
}
] |
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] |
[] |
[] |
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DerHautarzt.60470502.eng.abstr
|
DerHautarzt.60470502.eng.abstr
|
[
{
"id": "DerHautarzt.60470502.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Endogenous retroviral sequences ( ERV ) are integrated parts of the human genome . They make up at least 1% of the total genomic DNA . This pool of genetic material might help explain the long discussed role of retroviruses in autoimmune disease . Their proviral features suggest two possible models leading to autoimmune disease : the mobile insertion into a or near a somatic gene , changing its function , and the expression of proteins by ERV , which then might act as autoantigens or superantigens . These mechanisms are supported by prior studies of systemic lupus erythematosus ( SLE ) . In MRL-lpr/lpr mice with SLE-like disease the insertion of a mobile retroviral element , the early transposon ( ETn ) , into the second intron of the fas gene leads to reduced apoptosis , accumulation of lymphocytes and earlier mortality . Investigations of murine and human SLE demonstrate autoantibodies against self-proteins , which crossreact with retroviral proteins . Future investigations may further establish the interrelation between the activation of endogenous retroviral sequences and SLE with its multifactorial genetic determinants ."
],
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[
0,
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] |
[] |
[] |
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] |
DerHautarzt.60470510.eng.abstr
|
DerHautarzt.60470510.eng.abstr
|
[
{
"id": "DerHautarzt.60470510.eng.abstr-passage-0",
"type": "abstract",
"text": [
"To study the frequency and clinical aspects of cold urticaria in Central Europe , patient data from a university dermatology clinic and a private dermatology office between 1984-94 were analysed and the patients reexamined if possible . The incidence of cold urticaria was found to be 0.05% . Of the 56 patients with cold urticaria ( 31 women , 25 men ) , 49 had idiopathic cold urticaria . The mean age was 41.0 +/- 15.6 year , the mean duration of disease 7.9 +/- 5.8 years . Atopy was found in 46.5% of patients , and 23.2% of the patients suffered from other types of urticaria ( cholinergic , chronic idiopathic , dermographic , aquagenic and heat-induced ) . Laboratory examinations were only rarely abnormal . 44 patients were treated with antihistamines , with generally only moderate symptomatic improvement . Treatment with antibiotics ( penicillin , 1-2 mil IU/d over 2-4 weeks , n=18, or tetracyclines , 2 g/d over 2 weeks , n=10) induced full remission in 13 patients and symptomatic improvement in 8. During an average of 6.5 year-follow-up , 20 of 43 symptomatic patients went into spontaneous remission . The good therapeutic response to antibiotics in this study underlines the need for a better elucidation of the cause of cold urticaria , in view of possible infectious causes ."
],
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[
0,
1297
]
]
}
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}
] |
DerHautarzt.60470521.eng.abstr
|
DerHautarzt.60470521.eng.abstr
|
[
{
"id": "DerHautarzt.60470521.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Paratibial fasciotomy has been employed since 1981 to treat patients with chronic venous insufficiency ( CVI ) and therapy-resistant leg ulcers with severe lipodermatosclerosis . The characteristic morphological changes in CVI were evaluated shown before and after paratibial fasciotomy using computerized tomography ( CT ) and magnet resonance tomography ( MRT ) . 10 patients ( 6 female , 4 male ) were examined by CT and MRT pre- and postoperatively . Preoperatively there is a clear thickening of the dermis and subcutaneous field . In addition , the area around the achilles tendon is thickened , the fasciae are enlarged and the muscles of the lower leg show an increase of fatty tissue . A decrease of the cutaneous and subcutaneous thickening is seen postoperatively . The fasciotomy split is visible in most patients ."
],
"offsets": [
[
0,
827
]
]
}
] |
[
{
"id": "DerHautarzt.60470521.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"Paratibial"
],
"offsets": [
[
0,
10
]
],
"normalized": [
{
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"db_id": "C0030563"
}
]
},
{
"id": "DerHautarzt.60470521.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"patients"
],
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[
60,
68
]
],
"normalized": [
{
"db_name": "UMLS",
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}
]
},
{
"id": "DerHautarzt.60470521.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"therapy-resistant"
],
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[
115,
132
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0087111"
},
{
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"db_id": "C0039798"
}
]
},
{
"id": "DerHautarzt.60470521.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"leg"
],
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[
133,
136
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0023216"
}
]
},
{
"id": "DerHautarzt.60470521.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"ulcers"
],
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[
137,
143
]
],
"normalized": [
{
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"db_id": "C0041582"
}
]
},
{
"id": "DerHautarzt.60470521.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"venous insufficiency"
],
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[
82,
102
]
],
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{
"db_name": "UMLS",
"db_id": "C0042485"
}
]
},
{
"id": "DerHautarzt.60470521.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"leg ulcers"
],
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[
133,
143
]
],
"normalized": [
{
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"db_id": "C0023223"
}
]
},
{
"id": "DerHautarzt.60470521.eng.abstr-s1-t8",
"type": "umlsterm",
"text": [
"chronic venous insufficiency"
],
"offsets": [
[
74,
102
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0042485"
}
]
},
{
"id": "DerHautarzt.60470521.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"morphological"
],
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[
198,
211
]
],
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{
"db_name": "UMLS",
"db_id": "C0543482"
}
]
},
{
"id": "DerHautarzt.60470521.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"paratibial"
],
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[
265,
275
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030563"
}
]
},
{
"id": "DerHautarzt.60470521.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"tomography"
],
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306,
316
]
],
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{
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"db_id": "C0040395"
}
]
},
{
"id": "DerHautarzt.60470521.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"resonance"
],
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[
335,
344
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0459800"
}
]
},
{
"id": "DerHautarzt.60470521.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"tomography"
],
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[
345,
355
]
],
"normalized": [
{
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"db_id": "C0040395"
}
]
},
{
"id": "DerHautarzt.60470521.eng.abstr-s2-t6",
"type": "umlsterm",
"text": [
"computerized tomography"
],
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[
293,
316
]
],
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"db_id": "C0040405"
}
]
},
{
"id": "DerHautarzt.60470521.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"patients"
],
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[
369,
377
]
],
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}
]
},
{
"id": "DerHautarzt.60470521.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"female"
],
"offsets": [
[
382,
388
]
],
"normalized": [
{
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"db_id": "C0086287"
},
{
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"db_id": "C0015780"
}
]
},
{
"id": "DerHautarzt.60470521.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"male"
],
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[
393,
397
]
],
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{
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"db_id": "C0024554"
},
{
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}
]
},
{
"id": "DerHautarzt.60470521.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"dermis"
],
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505,
511
]
],
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}
]
},
{
"id": "DerHautarzt.60470521.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"tendon"
],
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580,
586
]
],
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"db_id": "C0039508"
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]
},
{
"id": "DerHautarzt.60470521.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"fasciae"
],
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606,
613
]
],
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"db_id": "C0015641"
}
]
},
{
"id": "DerHautarzt.60470521.eng.abstr-s5-t3",
"type": "umlsterm",
"text": [
"muscles"
],
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[
635,
642
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],
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{
"db_name": "UMLS",
"db_id": "C0026845"
}
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},
{
"id": "DerHautarzt.60470521.eng.abstr-s5-t4",
"type": "umlsterm",
"text": [
"leg"
],
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659
]
],
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}
]
},
{
"id": "DerHautarzt.60470521.eng.abstr-s5-t5",
"type": "umlsterm",
"text": [
"tissue"
],
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692
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],
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}
]
},
{
"id": "DerHautarzt.60470521.eng.abstr-s5-t6",
"type": "umlsterm",
"text": [
"fatty tissue"
],
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],
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]
],
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}
]
}
] |
[] |
[] |
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] |
DerHautarzt.60470526.eng.abstr
|
DerHautarzt.60470526.eng.abstr
|
[
{
"id": "DerHautarzt.60470526.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report on seven examples of this rare , only recently described benign tumor , which presented clinically as solitary elevated nodules on the lower ( n=5) and upper ( n=2) extremity , measuring between 0.6 and 1.1 cm in diameter . Histologically , all tumors were well-defined with a characteristic epidermal collarette . There were abundant ( 60-80% ) epithelioid cells with prominent cytoplasm , a vesicular nucleus and inconspicuous nucleolus , as well as a number of dilated blood vessels . Immunohistologically , tumor cells did not react with monocyte/macrophage antibodies ( KP1, MAC387 ) . In addition , there was no evidence of myofibroblastic differentiation ( alpha-smooth muscle actin and desmin negative ) . Thus , while immunohistological markers are helpful to exclude the diagnosis of other tumors , they do not shed light on the differentiation of epithelioid cell histiocytomas . The present cases are identical to those described originally . Recently similar lesions have been described in deeper parts of the corium as well as more cellular forms . Epithelioid cell histiocytoma represents a characteristic , poorly known variant within the spectrum of benign fibrous histiocytomas ; it needs to be distinguished clinically and histopathologically especially from Spitz nevus ."
],
"offsets": [
[
0,
1301
]
]
}
] |
[
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74,
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]
],
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},
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"id": "DerHautarzt.60470526.eng.abstr-s1-t2",
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],
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175,
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]
],
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{
"id": "DerHautarzt.60470526.eng.abstr-s1-t3",
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]
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{
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{
"id": "DerHautarzt.60470526.eng.abstr-s3-t3",
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] |
DerHautarzt.60470533.eng.abstr
|
DerHautarzt.60470533.eng.abstr
|
[
{
"id": "DerHautarzt.60470533.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report on two patients with postmenopausal frontal fibrosing alopecia . This recently described disease affects postmenopausal women and is characterized by progressive recession of the frontotemporal and parietal hair margins . It leads to a symmetrical band-like scarring area of alopecia 3-6 cm wide . Histological examination shows perifollicular fibrosis and lymphocytic inflammation concentrated around the isthmus and infundibular areas of the follicles . One of our two patients also had vulvar lichen sclerosus et atrophicus . An effective treatment for this type of postmenopausal alopecia is yet not known , but the course of the disease seems to be self-limited ."
],
"offsets": [
[
0,
678
]
]
}
] |
[
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],
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17,
25
]
],
"normalized": [
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}
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},
{
"id": "DerHautarzt.60470533.eng.abstr-s1-t2",
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"text": [
"alopecia"
],
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[
64,
72
]
],
"normalized": [
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]
},
{
"id": "DerHautarzt.60470533.eng.abstr-s2-t1",
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],
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[
99,
106
]
],
"normalized": [
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}
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[] |
[] |
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] |
DerHautarzt.60470537.eng.abstr
|
DerHautarzt.60470537.eng.abstr
|
[
{
"id": "DerHautarzt.60470537.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Two children developed multiple melanocytic naevi after polychemotherapy administered for acute lymphoblastic leukaemia in one and for non-Hodgkin lymphoma in the other . Induction of naevi does not seem to be related to specific agents used in chemotherapy , but rather to the immunosuppression resulting from multiple-agent chemotherapy . There are reports in the literature of both intrinsically and iatrogenically immunosuppressed patients who have developed multiple melanocytic naevi ."
],
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[
0,
491
]
]
}
] |
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] |
[] |
[] |
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{
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{
"id": "DerHautarzt.60470537.eng.abstr-s2-r12-t2.2-t1.1",
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DerHautarzt.60470541.eng.abstr
|
DerHautarzt.60470541.eng.abstr
|
[
{
"id": "DerHautarzt.60470541.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Purpura fulminans must be treated as an emergency in internal medicine and dermatology . Its characteristic features are the sudden development of progressively enlarging haemorrhagic skin necrosis , severe disseminated intravascular coagulation with consumption of anticoagulant factors , and signs of shock . Purpura fulminans can be classified into a neonatal form with inherited protein C deficiency and an acquired type for which multiple causes are known . Clinically it is characterized by massive ecchymosis with haemorrhagic blebs and acral necrosis . Histologically the lesions show widespread extravasation of erythrocytes and thrombosis of small vessels . Thrombocytopenia , decrease of coagulation factors , the presence of fibrinogen split products and fragmented erythrocytes in the blood smear help to confirm the diagnosis . The therapy includes fresh-frozen plasma , heparin , antibiotics and surgical debridement of necrotic areas . It is important to recognize the disease promptly because the mortality rate is about 30-40% and only quick intervention helps to save the life of the patient ."
],
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[
0,
1112
]
]
}
] |
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"id": "DerHautarzt.60470541.eng.abstr-s1-t2",
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{
"id": "DerHautarzt.60470541.eng.abstr-s2-t2",
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},
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"id": "DerHautarzt.60470541.eng.abstr-s2-t3",
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"necrosis"
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"id": "DerHautarzt.60470541.eng.abstr-s2-t5",
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"consumption"
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"id": "DerHautarzt.60470541.eng.abstr-s2-t6",
"type": "umlsterm",
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"id": "DerHautarzt.60470541.eng.abstr-s2-t7",
"type": "umlsterm",
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"signs"
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},
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"id": "DerHautarzt.60470541.eng.abstr-s2-t8",
"type": "umlsterm",
"text": [
"shock"
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},
{
"id": "DerHautarzt.60470541.eng.abstr-s2-t9",
"type": "umlsterm",
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{
"id": "DerHautarzt.60470541.eng.abstr-s3-t1",
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"id": "DerHautarzt.60470541.eng.abstr-s3-t3",
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"id": "DerHautarzt.60470541.eng.abstr-s3-t4",
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"id": "DerHautarzt.60470541.eng.abstr-s3-t7",
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"id": "DerHautarzt.60470541.eng.abstr-s4-t1",
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"id": "DerHautarzt.60470541.eng.abstr-s4-t2",
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}
] |
[] |
[] |
[
{
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] |
DerHautarzt.60470545.eng.abstr
|
DerHautarzt.60470545.eng.abstr
|
[
{
"id": "DerHautarzt.60470545.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 49-year-old patient developed acquired generalized cutis laxa , manifest as involvement of the elastic fibres of the dermis and the internal organs , leading to pulmonary emphysema , bilateral inguinal hernia and two oesophageal diverticula . The patient's serum levels of IgG lambda paraprotein were elevated . Direct immunofluorescence examination revealed intensive linear deposits of IgG lambda light chains , an early component of complement C1q and discrete C3 deposits . The deposits were found along the preserved elastic fibres in the dermis , especially in the papillary dermis , at the dermoepidermal junction around the sweat and sebaceous glands and in the walls of small vessels . Dermal alterations of this kind have not been described previously ."
],
"offsets": [
[
0,
765
]
]
}
] |
[
{
"id": "DerHautarzt.60470545.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"patient"
],
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[
14,
21
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.60470545.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"dermis"
],
"offsets": [
[
119,
125
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011646"
}
]
},
{
"id": "DerHautarzt.60470545.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"emphysema"
],
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[
173,
182
]
],
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{
"db_name": "UMLS",
"db_id": "C0013990"
},
{
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}
]
},
{
"id": "DerHautarzt.60470545.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"hernia"
],
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[
204,
210
]
],
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{
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"db_id": "C0019270"
}
]
},
{
"id": "DerHautarzt.60470545.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"oesophageal"
],
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[
219,
230
]
],
"normalized": [
{
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"db_id": "C0014852"
}
]
},
{
"id": "DerHautarzt.60470545.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"diverticula"
],
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[
231,
242
]
],
"normalized": [
{
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"db_id": "C0012817"
}
]
},
{
"id": "DerHautarzt.60470545.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"cutis laxa"
],
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[
53,
63
]
],
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{
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"db_id": "C0010495"
}
]
},
{
"id": "DerHautarzt.60470545.eng.abstr-s1-t8",
"type": "umlsterm",
"text": [
"pulmonary emphysema"
],
"offsets": [
[
163,
182
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0034067"
}
]
},
{
"id": "DerHautarzt.60470545.eng.abstr-s1-t9",
"type": "umlsterm",
"text": [
"inguinal hernia"
],
"offsets": [
[
195,
210
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0019294"
}
]
},
{
"id": "DerHautarzt.60470545.eng.abstr-s1-t10",
"type": "umlsterm",
"text": [
"oesophageal diverticula"
],
"offsets": [
[
219,
242
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0014854"
}
]
},
{
"id": "DerHautarzt.60470545.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"IgG"
],
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[
275,
278
]
],
"normalized": [
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"db_id": "C0020852"
}
]
},
{
"id": "DerHautarzt.60470545.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"paraprotein"
],
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[
286,
297
]
],
"normalized": [
{
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"db_id": "C0030490"
}
]
},
{
"id": "DerHautarzt.60470545.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"Direct"
],
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[
314,
320
]
],
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"db_id": "C0700157"
}
]
},
{
"id": "DerHautarzt.60470545.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"immunofluorescence"
],
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[
321,
339
]
],
"normalized": [
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"db_id": "C0079603"
}
]
},
{
"id": "DerHautarzt.60470545.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"IgG"
],
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[
390,
393
]
],
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]
},
{
"id": "DerHautarzt.60470545.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"light"
],
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401,
406
]
],
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]
},
{
"id": "DerHautarzt.60470545.eng.abstr-s3-t5",
"type": "umlsterm",
"text": [
"C1q"
],
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449,
452
]
],
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},
{
"id": "DerHautarzt.60470545.eng.abstr-s3-t6",
"type": "umlsterm",
"text": [
"Direct immunofluorescence"
],
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314,
339
]
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]
},
{
"id": "DerHautarzt.60470545.eng.abstr-s3-t7",
"type": "umlsterm",
"text": [
"complement C1q"
],
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]
],
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},
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"id": "DerHautarzt.60470545.eng.abstr-s3-t8",
"type": "umlsterm",
"text": [
"lambda light chains"
],
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394,
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}
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},
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"id": "DerHautarzt.60470545.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"dermis"
],
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546,
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]
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},
{
"id": "DerHautarzt.60470545.eng.abstr-s4-t2",
"type": "umlsterm",
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"dermis"
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}
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},
{
"id": "DerHautarzt.60470545.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"sweat"
],
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634,
639
]
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{
"id": "DerHautarzt.60470545.eng.abstr-s4-t4",
"type": "umlsterm",
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"vessels"
],
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},
{
"id": "DerHautarzt.60470545.eng.abstr-s4-t5",
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"text": [
"sebaceous glands"
],
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}
] |
[] |
[] |
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}
] |
DerHautarzt.60470550.eng.abstr
|
DerHautarzt.60470550.eng.abstr
|
[
{
"id": "DerHautarzt.60470550.eng.abstr-passage-0",
"type": "abstract",
"text": [
"An 82-year-old patient with untreated chronic lymphatic leukaemia known for 6 years developed large livid red plaques with central blisters and subsequent ulceration of the lower legs . Reactive angioendotheliomatosis was diagnosed based on histological immunohistological and electronmicroscopic examination , since proliferating endothelial cells with intravascular fibrin thrombi were identified . When the leukaemia was treated the skin eruption healed completely ."
],
"offsets": [
[
0,
469
]
]
}
] |
[
{
"id": "DerHautarzt.60470550.eng.abstr-s1-t1",
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"text": [
"patient"
],
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[
15,
22
]
],
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{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.60470550.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"leukaemia"
],
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[
56,
65
]
],
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{
"db_name": "UMLS",
"db_id": "C0023418"
}
]
},
{
"id": "DerHautarzt.60470550.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"plaques"
],
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[
110,
117
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011389"
},
{
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"db_id": "C0333463"
}
]
},
{
"id": "DerHautarzt.60470550.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"blisters"
],
"offsets": [
[
131,
139
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0005758"
}
]
},
{
"id": "DerHautarzt.60470550.eng.abstr-s1-t5",
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"text": [
"ulceration"
],
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[
155,
165
]
],
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{
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"db_id": "C0041582"
}
]
},
{
"id": "DerHautarzt.60470550.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"legs"
],
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[
179,
183
]
],
"normalized": [
{
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"db_id": "C0023216"
}
]
},
{
"id": "DerHautarzt.60470550.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"lymphatic leukaemia"
],
"offsets": [
[
46,
65
]
],
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{
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"db_id": "C0023448"
}
]
},
{
"id": "DerHautarzt.60470550.eng.abstr-s1-t8",
"type": "umlsterm",
"text": [
"chronic lymphatic leukaemia"
],
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[
38,
65
]
],
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{
"db_name": "UMLS",
"db_id": "C0023458"
}
]
},
{
"id": "DerHautarzt.60470550.eng.abstr-s2-t1",
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"text": [
"cells"
],
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[
343,
348
]
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"normalized": [
{
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"db_id": "C0007634"
}
]
},
{
"id": "DerHautarzt.60470550.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"fibrin"
],
"offsets": [
[
368,
374
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0015982"
},
{
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"db_id": "C0060327"
}
]
},
{
"id": "DerHautarzt.60470550.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"thrombi"
],
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[
375,
382
]
],
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{
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"db_id": "C0087086"
}
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},
{
"id": "DerHautarzt.60470550.eng.abstr-s3-t1",
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"text": [
"leukaemia"
],
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[
410,
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]
],
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{
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}
]
},
{
"id": "DerHautarzt.60470550.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"skin"
],
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[
436,
440
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0037267"
}
]
}
] |
[] |
[] |
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] |
DerHautarzt.60470587.eng.abstr
|
DerHautarzt.60470587.eng.abstr
|
[
{
"id": "DerHautarzt.60470587.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Recently , several reports have been describing a possible relation between Helicobacter pylori infection of the gastric mucosa and dermatological diseases . Associations have been reported for urticaria , roascea , Sjoegren's syndrome and Schoenlein-Henoch purpura . In this paper we review the current knowledge on Helicobacter pylori infection and its relevance for skin diseases , especially its clinical and pathophysiological aspects ."
],
"offsets": [
[
0,
441
]
]
}
] |
[
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]
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{
"id": "DerHautarzt.60470587.eng.abstr-s1-t2",
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},
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113,
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{
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] |
DerHautarzt.60470599.eng.abstr
|
DerHautarzt.60470599.eng.abstr
|
[
{
"id": "DerHautarzt.60470599.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 52 year old female with Parry-Romberg syndrome presented with gradual atrophy of the subcutaneous fat and muscle on her chest and back . The disease process was limited to the C3 to T2 dermatomes on the right side . In addition , there was muscle atrophy of the right arm and extending down the back to T10, als well as right sided paralysis of the diaphragm . Sympathetic nerve blockage reduced pain and hyperesthesia ; no progression was seen over several months using NMR to monitor the patient . The Parry-Romberg syndrome has been defined in many ways ; in view of this unusual case , we review the literature , attempting to provide a more accurate case definition ."
],
"offsets": [
[
0,
674
]
]
}
] |
[
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"id": "DerHautarzt.60470599.eng.abstr-s1-t1",
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"old"
],
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13
]
],
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{
"id": "DerHautarzt.60470599.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"female"
],
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[
14,
20
]
],
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"db_id": "C0086287"
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}
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},
{
"id": "DerHautarzt.60470599.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"syndrome"
],
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40,
48
]
],
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{
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]
},
{
"id": "DerHautarzt.60470599.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"atrophy"
],
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[
72,
79
]
],
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{
"db_name": "UMLS",
"db_id": "C0004255"
}
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},
{
"id": "DerHautarzt.60470599.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"fat"
],
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[
100,
103
]
],
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{
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}
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},
{
"id": "DerHautarzt.60470599.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"muscle"
],
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[
108,
114
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0026845"
}
]
},
{
"id": "DerHautarzt.60470599.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"chest"
],
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[
122,
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]
],
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{
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},
{
"id": "DerHautarzt.60470599.eng.abstr-s1-t8",
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"Parry-Romberg syndrome"
],
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26,
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]
],
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}
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},
{
"id": "DerHautarzt.60470599.eng.abstr-s2-t1",
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"disease"
],
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150
]
],
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}
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},
{
"id": "DerHautarzt.60470599.eng.abstr-s2-t2",
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"text": [
"right"
],
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[
205,
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]
],
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{
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}
]
},
{
"id": "DerHautarzt.60470599.eng.abstr-s3-t1",
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"muscle"
],
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242,
248
]
],
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}
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},
{
"id": "DerHautarzt.60470599.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"atrophy"
],
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[
249,
256
]
],
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{
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]
},
{
"id": "DerHautarzt.60470599.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"right"
],
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264,
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],
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}
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},
{
"id": "DerHautarzt.60470599.eng.abstr-s3-t4",
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"arm"
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],
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},
{
"id": "DerHautarzt.60470599.eng.abstr-s3-t5",
"type": "umlsterm",
"text": [
"back"
],
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]
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}
]
},
{
"id": "DerHautarzt.60470599.eng.abstr-s3-t6",
"type": "umlsterm",
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"paralysis"
],
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]
],
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"db_id": "C0030440"
}
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},
{
"id": "DerHautarzt.60470599.eng.abstr-s3-t7",
"type": "umlsterm",
"text": [
"diaphragm"
],
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351,
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]
],
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},
{
"id": "DerHautarzt.60470599.eng.abstr-s3-t8",
"type": "umlsterm",
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],
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242,
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]
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"db_id": "C0026846"
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},
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"id": "DerHautarzt.60470599.eng.abstr-s4-t1",
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"text": [
"nerve"
],
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"pain"
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},
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"id": "DerHautarzt.60470599.eng.abstr-s4-t3",
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"text": [
"hyperesthesia"
],
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"id": "DerHautarzt.60470599.eng.abstr-s4-t4",
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"NMR"
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"patient"
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] |
[] |
[] |
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] |
DerHautarzt.60470604.eng.abstr
|
DerHautarzt.60470604.eng.abstr
|
[
{
"id": "DerHautarzt.60470604.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In the country city of Ansbach , Germany all cases of varicella-zoster virus infection seen by dermatologists , pediatricians and general practitioneers were registered over a period of 16 months , from February 1992 until May 1993. 152 patients were clinically diagnosed with herpes zoster and 437 patients with chickenpox . The population-based incidence of zoster infections was 22.6 per 10,000 inhabitants per year , while the incidence of chickenpox was 42.4. There was a slight predominance of male patients with zoster . There was also a marked influence of age and sex , on the localization of the involved nerve segments . Zoster was seen in patients of all ages but there was a clear predominance in older patients . The peak of the disease occurred in the eighth decade . In patients with chickenpox , the sex ratio was equal . The disease typically occurs in children and we observed a predominance of the cases in the first decade ."
],
"offsets": [
[
0,
945
]
]
}
] |
[
{
"id": "DerHautarzt.60470604.eng.abstr-s1-t1",
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],
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[
15,
19
]
],
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"db_id": "C0008848"
}
]
},
{
"id": "DerHautarzt.60470604.eng.abstr-s1-t2",
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"text": [
"Germany"
],
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[
33,
40
]
],
"normalized": [
{
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"db_id": "C0017480"
}
]
},
{
"id": "DerHautarzt.60470604.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"varicella-zoster"
],
"offsets": [
[
54,
70
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0008049"
}
]
},
{
"id": "DerHautarzt.60470604.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"varicella-zoster"
],
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54,
70
]
],
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},
{
"id": "DerHautarzt.60470604.eng.abstr-s1-t5",
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"text": [
"virus"
],
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[
71,
76
]
],
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{
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"db_id": "C0521026"
}
]
},
{
"id": "DerHautarzt.60470604.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"infection"
],
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77,
86
]
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] |
DerHautarzt.60470610.eng.abstr
|
DerHautarzt.60470610.eng.abstr
|
[
{
"id": "DerHautarzt.60470610.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Panfolliculoma is a rare benign neoplasm showing morphological similarities to the trichogenic trichoblastoma of Headington and the trichoblastoma of Ackerman . Eight patients have been previously reported ; we add four additional patients . Their ages ranged from the 2nd to the 6th decade . The neoplasms were primarily situated on the head and the trunk . Clinical examination revealed a skin colored or red , dermal cystic nodule . The histological appearance of the panfolliculoma was characterized by symmetry , sharp circumscription and regular aggregations of cells , which were in parts solid or cystic . Additionally , follicular germs and papillae , matrical , inner and outer rooth sheath differentiation were identified . These varied forms of follicular differentiation were confirmed by the immunohistochemical expression of cytokeratins in different epithelial cells . Panfolliculoma is a benign neoplasm with proven morphological and immunhistochemical follicular differentiation ."
],
"offsets": [
[
0,
998
]
]
}
] |
[
{
"id": "DerHautarzt.60470610.eng.abstr-s1-t1",
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],
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40
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],
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]
},
{
"id": "DerHautarzt.60470610.eng.abstr-s1-t2",
"type": "umlsterm",
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"morphological"
],
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[
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62
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],
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}
]
},
{
"id": "DerHautarzt.60470610.eng.abstr-s1-t3",
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"benign neoplasm"
],
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25,
40
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],
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},
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"id": "DerHautarzt.60470610.eng.abstr-s2-t1",
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"patients"
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"patients"
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},
{
"id": "DerHautarzt.60470610.eng.abstr-s3-t1",
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"text": [
"ages"
],
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248,
252
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]
},
{
"id": "DerHautarzt.60470610.eng.abstr-s4-t1",
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"text": [
"neoplasms"
],
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[
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306
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}
]
},
{
"id": "DerHautarzt.60470610.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"head"
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[
338,
342
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{
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"db_id": "C0018670"
}
]
},
{
"id": "DerHautarzt.60470610.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"skin"
],
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[
391,
395
]
],
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{
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"db_id": "C0037267"
}
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},
{
"id": "DerHautarzt.60470610.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"Clinical examination"
],
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[
359,
379
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"db_id": "C0031809"
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]
},
{
"id": "DerHautarzt.60470610.eng.abstr-s6-t1",
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"cells"
],
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]
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"forms"
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"db_id": "C0376315"
}
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},
{
"id": "DerHautarzt.60470610.eng.abstr-s8-t2",
"type": "umlsterm",
"text": [
"cytokeratins"
],
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[
840,
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],
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"db_id": "C0010803"
}
]
},
{
"id": "DerHautarzt.60470610.eng.abstr-s8-t3",
"type": "umlsterm",
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"cells"
],
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]
],
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}
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},
{
"id": "DerHautarzt.60470610.eng.abstr-s8-t4",
"type": "umlsterm",
"text": [
"epithelial cells"
],
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"db_id": "C0014597"
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},
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"id": "DerHautarzt.60470610.eng.abstr-s9-t1",
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"neoplasm"
],
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"id": "DerHautarzt.60470610.eng.abstr-s9-t2",
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"text": [
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],
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},
{
"id": "DerHautarzt.60470610.eng.abstr-s9-t3",
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],
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],
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},
{
"id": "DerHautarzt.60470610.eng.abstr-s9-t4",
"type": "umlsterm",
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],
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]
],
"normalized": [
{
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}
]
}
] |
[] |
[] |
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] |
DerHautarzt.60470624.eng.abstr
|
DerHautarzt.60470624.eng.abstr
|
[
{
"id": "DerHautarzt.60470624.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In a 7-year-old boy , ichthyosis vulgaris was treated with a 10% ointment for application over a large area of the body surface . In this way , the child received 400 g salicylic acid ( 0.6 g/kg body weight per day ) percutaneously over a period of 4 weeks . The patient was referred to hospital by the family doctor : he was in a deep somnolent state , apparently caused by hyperventilation following wheezing , vomiting , tinnitus and vertigo . Salicylate intoxication was suspected because of metabolic acidosis , an anion gap and respiratory overcompensation . The diagnosis was confirmed by a serum salicylate level of 985 µg/ml ( therapeutic level 150-300 µg/ml). Following forced diuresis and alkalization with sodium bicarbonate , haemodialysis was unnecessary . As the salicylate level declined to values within the therapeutic range , the patient started to recover conciousness , waking on the 4th day . By day 6 there were still obvious neurological deficiencies . Fecal incontinence , bilateral ptosis and intermittent diverging strabismus on the right persisted for some weeks . It was 6 months before complete neurological resolution was achieved . The pathogenesis of salicylate toxicity and the need for safer therapies for ichthyosis vulgaris are discussed ."
],
"offsets": [
[
0,
1276
]
]
}
] |
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] |
[] |
[] |
[
{
"id": "DerHautarzt.60470624.eng.abstr-s1-r1-t2.1-t1.1",
"type": "causes",
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DerHautarzt.60470628.eng.abstr
|
DerHautarzt.60470628.eng.abstr
|
[
{
"id": "DerHautarzt.60470628.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Atopic eczema is one of the most frequent dermatological diseases , with a still increasing incidence . Although its etiopathogenesis is still not completely understood , a variety of triggering factors are known . The following case report describes the clinical course of atopic dermatitis in a 2-year-old boy in whom both IgE-mediated allergic reactions and psychological factors were involved in triggering and maintenance of skin lesions . This demonstrates how important both dermatological therapy and close cooperation with the field of psychosomatic medicine can be ."
],
"offsets": [
[
0,
576
]
]
}
] |
[
{
"id": "DerHautarzt.60470628.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"eczema"
],
"offsets": [
[
7,
13
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[] |
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] |
DerHautarzt.60470634.eng.abstr
|
DerHautarzt.60470634.eng.abstr
|
[
{
"id": "DerHautarzt.60470634.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 38-year-old HIV-positive man had several attacks of high fever associated with extensive perspiration over a 10-week period . Simultaneously , he developed molluscum contagiosum-like papules and an erythematous plaque on the face , ulcerated papules on both shoulders and buttocks and subcutaneous nodules on the arms . Histological examination of biopsy specimens revealed a diffuse , histiocytic infiltrate with abundant rod-shaped bacteria . Mycobacterium avium complex was cultured from the tissue and Mycobacterium avium complex DNA was detected by the polymerase chain reaction . The diagnosis of disseminated disease was additionally confirmed by culturing Mycobacterium avium complex from blood , sputum and stool . The skin lesions healed completely within 10 weeks by a multiagent as the patient was treated with a drug therapy . We describe the differential diagnosis , diagnostic procedures and therapy of disseminated infection with Mycobacterium avium complex ."
],
"offsets": [
[
0,
977
]
]
}
] |
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{
"id": "DerHautarzt.60470634.eng.abstr-s1-t2",
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{
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"perspiration"
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[] |
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DerHautarzt.60470638.eng.abstr
|
DerHautarzt.60470638.eng.abstr
|
[
{
"id": "DerHautarzt.60470638.eng.abstr-passage-0",
"type": "abstract",
"text": [
"White piedra is a rare hair infection of man and certain animals , caused by the widespread Trichosporon fungi . The infection is characterized clinically by whitish , soft and easily removable coating of the hair shafts ; however , the shafts may be destroyed by the pathogens invading at localized points . While all body hair may be affected , the pubic hair is most frequently affected . This paper is the first report genital white piedra in a 34-year-old Central European man . In all , 22 cases have been described world-wide in young men ranging in age from 20 to 40 years . Only 2 men , aged 42 and 53 years , do not fall in this range . Recently , a major African study disclosed this disease in women for the first time . In moderate latitudes , however , this infection appears to occur almost exclusively in young men ."
],
"offsets": [
[
0,
832
]
]
}
] |
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[] |
[] |
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DerHautarzt.60470644.eng.abstr
|
DerHautarzt.60470644.eng.abstr
|
[
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"id": "DerHautarzt.60470644.eng.abstr-passage-0",
"type": "abstract",
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"Photodynamic therapy is based on the accumulation of photosensitizing drugs in tumours and subsequent activation by visible light , leading to the release of singlet oxygen in photochemical reactions . Besides the treatment of precancerous lesions and malignant tumours in superficial sites , new experimental indications , such as psoriasis , are being investigated . The development of new photosensitizing agents for topical application and appropriate light sources has led to increasing interest in this promising treatment modality among dermatologists . This historical review deals with the scientific investigations of photodynamic therapy and diagnosis that started with the experiments of Oscar Raab at the end of the nineteenth century ."
],
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0,
749
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]
}
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}
] |
[] |
[] |
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},
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},
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},
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},
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},
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}
] |
DerHautarzt.60470673.eng.abstr
|
DerHautarzt.60470673.eng.abstr
|
[
{
"id": "DerHautarzt.60470673.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Cutaneous osteomas occur rarely ; they represent the formation of bone in the skin . Primary and secondary forms of ossification can be distinguished . We describe the primary form of ossification in a child with Albright's hereditary osteodystrophy ."
],
"offsets": [
[
0,
251
]
]
}
] |
[
{
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"osteomas"
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10,
18
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{
"id": "DerHautarzt.60470673.eng.abstr-s1-t2",
"type": "umlsterm",
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"bone"
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{
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78,
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] |
[] |
[] |
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] |
DerHautarzt.60470676.eng.abstr
|
DerHautarzt.60470676.eng.abstr
|
[
{
"id": "DerHautarzt.60470676.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Ulcers in chronic venous insufficiency , especially in postthrombotic syndrome , are often resistant to compression therapy . They can be treated effectively by the dermatologic surgeon with a fairly simple operative procedure . The removal of the ulcer together with the extensive lipodermatosclerosis by Humby knife ( shave-therapy ) and immediate grafting with a meshed split skin graft - possibly in combination with ligation of insufficient perforator veins - yields very good success rates . The results in 13 patients ( 18 legs ) with an average follow up period of 11 months ( up to 20 months ) are reported ."
],
"offsets": [
[
0,
617
]
]
}
] |
[
{
"id": "DerHautarzt.60470676.eng.abstr-s1-t1",
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"Ulcers"
],
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0,
6
]
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},
{
"id": "DerHautarzt.60470676.eng.abstr-s1-t2",
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"syndrome"
],
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},
{
"id": "DerHautarzt.60470676.eng.abstr-s1-t3",
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"therapy"
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{
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}
]
},
{
"id": "DerHautarzt.60470676.eng.abstr-s1-t4",
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"venous insufficiency"
],
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18,
38
]
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"db_id": "C0042485"
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},
{
"id": "DerHautarzt.60470676.eng.abstr-s1-t5",
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"postthrombotic syndrome"
],
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[
55,
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"db_id": "C0032807"
}
]
},
{
"id": "DerHautarzt.60470676.eng.abstr-s1-t6",
"type": "umlsterm",
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"chronic venous insufficiency"
],
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[
10,
38
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{
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"db_id": "C0042485"
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},
{
"id": "DerHautarzt.60470676.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"procedure"
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[
217,
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"db_id": "C0184661"
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},
{
"id": "DerHautarzt.60470676.eng.abstr-s2-t2",
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"operative procedure"
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}
]
},
{
"id": "DerHautarzt.60470676.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"ulcer"
],
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[
248,
253
]
],
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{
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}
]
},
{
"id": "DerHautarzt.60470676.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"grafting"
],
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},
{
"id": "DerHautarzt.60470676.eng.abstr-s3-t3",
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"skin"
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},
{
"id": "DerHautarzt.60470676.eng.abstr-s3-t4",
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]
},
{
"id": "DerHautarzt.60470676.eng.abstr-s3-t5",
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]
},
{
"id": "DerHautarzt.60470676.eng.abstr-s3-t6",
"type": "umlsterm",
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"veins"
],
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457,
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],
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},
{
"id": "DerHautarzt.60470676.eng.abstr-s3-t7",
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"skin graft"
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379,
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{
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]
},
{
"id": "DerHautarzt.60470676.eng.abstr-s4-t1",
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]
},
{
"id": "DerHautarzt.60470676.eng.abstr-s4-t2",
"type": "umlsterm",
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"legs"
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},
{
"id": "DerHautarzt.60470676.eng.abstr-s4-t3",
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"period"
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]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0025344"
}
]
}
] |
[] |
[] |
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{
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{
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{
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{
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{
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DerHautarzt.60470682.eng.abstr
|
DerHautarzt.60470682.eng.abstr
|
[
{
"id": "DerHautarzt.60470682.eng.abstr-passage-0",
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"text": [
"Dermatography is the application of tattooing techniques in medicine . In the past , several techniques were tried but none led to reproducible results . Dermatography has been improved over the last ten years , providing techniques which are both generally applicable and reproducible . It is a suitable treatment modality for permanently camouflaging disturbing discolorations and scars . This paper covers technical and medical aspects of dermatography , as well the indications ."
],
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0,
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]
}
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[] |
[] |
[
{
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DerHautarzt.60470686.eng.abstr
|
DerHautarzt.60470686.eng.abstr
|
[
{
"id": "DerHautarzt.60470686.eng.abstr-passage-0",
"type": "abstract",
"text": [
"115 andrological patients were studied with psychological self-assessment tests to assess both their motivation concerning parenthood , and their own explanations for the causes . Additionally self-esteem was evaluated in 51 patients . The main results were : Motivation concerning parenthood is of greater importance in coping with involuntary childlessness than objective andrological data . Patients assess their situation quite realistically ; no tendency to misinterpret the medical data in order to defend negative feelings and to protect self-esteem could be found . Most patients with reduced fertility consider this situation a challenge and are willing to mobilize resources and the help of others in order to cope . Self-esteem was only threatened in those patients with longlasting unvoluntary childlessness and little acceptance of medical infertility treatment and parenting substitutes , e.g. adopting a child ."
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}
] |
[] |
[] |
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DerHautarzt.60470701.eng.abstr
|
DerHautarzt.60470701.eng.abstr
|
[
{
"id": "DerHautarzt.60470701.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 35-year-old woman suffering from Crohn's disease for 3 years developed painful erythematous nodular lesions predominantly on the dorsa of her hands and feet , as well as on her elbows and wrists . The clinical features and histopathological picture of leukocytoclastic vasculitis were both highly suggestive of erythema elevatum diutinum . No improvement of the skin lesions was observed during treatment with high doses of oral steroids . In contrast , treatment with dapsone resulted in a marked reduction of skin lesions . During a new attack of her Crohn's disease the erythema elevatum diutinum lesions flared again . The parallel clinical course of erythema elevatum diutinum and Crohn's disease , as well as the detection of immune complexes and neutrophilic granulocytes in lesions of both diseases , strongly suggest a common etiology . This hypothesis is discussed in context with this case and the recent literature ."
],
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0,
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]
]
}
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[] |
[] |
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DerHautarzt.60470705.eng.abstr
|
DerHautarzt.60470705.eng.abstr
|
[
{
"id": "DerHautarzt.60470705.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Paraffinomas of the male genitalia are now rare . We report on a Russian patient with subcutaneous nodules of the penis and the prepuce . Injections of exogenous lipids into the male genitalia are still performed in many Eastern European countries . Thus , a paraffinoma should be considered in the differential diagnosis of subcutaneous nodules of the male genitalia in patients from these areas ."
],
"offsets": [
[
0,
398
]
]
}
] |
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] |
[] |
[] |
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DerHautarzt.60470708.eng.abstr
|
DerHautarzt.60470708.eng.abstr
|
[
{
"id": "DerHautarzt.60470708.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report two patients with bullous phototoxic contact dermatitis caused by Dictamnus albus L. ( gas plant ) which belongs to the Rutaceae family . In both cases long lasting postinflammatory hyperpigmentations were observed as a result of the phototoxic contact dermatitis . The phototoxic components of Dictamnus albus L. are the furocoumarins 5-methoxypsoralen ( bergapten ) and 8-methoxypsoralen , and the alkaloid dictamnin whose phototoxic properties were recently discovered . Even though reactions to the gas plant have been infrequently reported , it is becoming more popular with gardenus and should be considered in the differential diagnosis of phototoxic contact dermatitis ."
],
"offsets": [
[
0,
688
]
]
}
] |
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"id": "DerHautarzt.60470708.eng.abstr-s1-t3",
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"albus"
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{
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"db_id": "C0001898"
}
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},
{
"id": "DerHautarzt.60470708.eng.abstr-s1-t4",
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"gas"
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{
"id": "DerHautarzt.60470708.eng.abstr-s1-t5",
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"plant"
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"id": "DerHautarzt.60470708.eng.abstr-s1-t8",
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"phototoxic contact dermatitis"
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}
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"id": "DerHautarzt.60470708.eng.abstr-s2-t1",
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"dermatitis"
],
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263,
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{
"id": "DerHautarzt.60470708.eng.abstr-s2-t2",
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"contact dermatitis"
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"id": "DerHautarzt.60470708.eng.abstr-s2-t3",
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"id": "DerHautarzt.60470708.eng.abstr-s3-t1",
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},
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"id": "DerHautarzt.60470708.eng.abstr-s3-t2",
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"id": "DerHautarzt.60470708.eng.abstr-s3-t3",
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"id": "DerHautarzt.60470708.eng.abstr-s3-t4",
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"id": "DerHautarzt.60470708.eng.abstr-s3-t5",
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"id": "DerHautarzt.60470708.eng.abstr-s4-t1",
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] |
[] |
[] |
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] |
DerHautarzt.60470711.eng.abstr
|
DerHautarzt.60470711.eng.abstr
|
[
{
"id": "DerHautarzt.60470711.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report a patient who developed malignant transformation of a cellular blue nevus . At the age of 19 years the congenital , pigmented tumor on the left buttock was histopathologically diagnosed as cellular blue nevus . Thirty years later the tumor dramatically increased in size , involving the entire left buttock within several months . Multiple biopsies revealed the presence of a cellular blue nevus within the papillary dermis and an invasive , pleomorphic pigmented sarcoma in the depth of the tissue spreading into subcutis and skeletal muscle . Both benign and malignant cells were S100+, vimentin+ and HMB-45+, but only the malignant tumor cells stained positive for the proliferating cell nuclear antigen . General examination disclosed multiple metastases in the paraaortal lymph nodes and the retroperitoneum as well as a single brain metastasis . Despite palliative therapy with ionizing radiation and chemotherapy , the patient developed generalized metastases and died within weeks . This case clearly confirms that cellular blue nevi have the potential for malignant transformation and that the malignant variant may behave aggressively just as a malignant melanoma ."
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[] |
[] |
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DerHautarzt.60470739.eng.abstr
|
DerHautarzt.60470739.eng.abstr
|
[
{
"id": "DerHautarzt.60470739.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Human papillomaviruses induce benign or malignant epithelial proliferations in both skin or mucosa and are involved in the development of anogenital cancer . One can consider two approaches towards vaccine development : prevention of infection by prophylactic induction of virus neutralizing antibodies or therapeutic vaccination which would lead to regression of already existing lesions . Neutralizing antibodies are directed against 3-dimensional structures on intact virions . Such antibodies which are protective in model systems can be induced safely by DNA-free \" virus-like-particles \" . These constructs are candidates for a prophylactic vaccine . A further approach to optimize the vaccination strategy concentrates on immunotherapy of precancerous or malignant lesions by induction of a specific cell-mediated immune response . Hypothetically the transforming papillomavirus proteins which are expressed in basal layers of the epidermis could be used as a therapeutic vaccine in the form of synthetic peptides ."
],
"offsets": [
[
0,
1022
]
]
}
] |
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] |
DerHautarzt.60470744.eng.abstr
|
DerHautarzt.60470744.eng.abstr
|
[
{
"id": "DerHautarzt.60470744.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Different mite species may infest humans temporarily ; such arthropods should be considered a possible cause of pruritic skin reactions of unclear origin . Pseudo-scabies is a common problem . This self-limiting dermatosis may often be misdiagnosed . Several mite species including Sarcoptes scabiei var . canis , Sarcoptes scabiei var . bovis , Notoedres cati , Cheyletiella yasguri , Cheyletiella blakei , Dermanyssus gallinae and Ophionyssus natricis may infest human skin , causing symptoms . Other less common animal mites , Neotrombicula autumnalis and foodstuff mites are also discussed ."
],
"offsets": [
[
0,
595
]
]
}
] |
[
{
"id": "DerHautarzt.60470744.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"mite"
],
"offsets": [
[
10,
14
]
],
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{
"db_name": "UMLS",
"db_id": "C0026229"
},
{
"db_name": "UMLS",
"db_id": "C0026231"
}
]
},
{
"id": "DerHautarzt.60470744.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"humans"
],
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[
34,
40
]
],
"normalized": [
{
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"db_id": "C0020114"
}
]
},
{
"id": "DerHautarzt.60470744.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"arthropods"
],
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[
60,
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]
],
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{
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"db_id": "C0003903"
}
]
},
{
"id": "DerHautarzt.60470744.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"cause"
],
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[
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]
],
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{
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"db_id": "C0015127"
}
]
},
{
"id": "DerHautarzt.60470744.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"skin"
],
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[
121,
125
]
],
"normalized": [
{
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"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.60470744.eng.abstr-s1-t6",
"type": "umlsterm",
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"origin"
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[
147,
153
]
],
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{
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"db_id": "C0079946"
}
]
},
{
"id": "DerHautarzt.60470744.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"Pseudo-scabies"
],
"offsets": [
[
156,
170
]
],
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"db_id": "C0036262"
}
]
},
{
"id": "DerHautarzt.60470744.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"dermatosis"
],
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},
{
"id": "DerHautarzt.60470744.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"mite"
],
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[
259,
263
]
],
"normalized": [
{
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"db_id": "C0026229"
},
{
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}
]
},
{
"id": "DerHautarzt.60470744.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"Sarcoptes scabiei"
],
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[
282,
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]
],
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{
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}
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},
{
"id": "DerHautarzt.60470744.eng.abstr-s5-t1",
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"canis"
],
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]
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]
},
{
"id": "DerHautarzt.60470744.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"Sarcoptes scabiei"
],
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[
314,
331
]
],
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]
},
{
"id": "DerHautarzt.60470744.eng.abstr-s6-t1",
"type": "umlsterm",
"text": [
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],
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],
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}
]
},
{
"id": "DerHautarzt.60470744.eng.abstr-s6-t2",
"type": "umlsterm",
"text": [
"skin"
],
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[
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]
],
"normalized": [
{
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"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.60470744.eng.abstr-s6-t3",
"type": "umlsterm",
"text": [
"symptoms"
],
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]
},
{
"id": "DerHautarzt.60470744.eng.abstr-s7-t1",
"type": "umlsterm",
"text": [
"animal"
],
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[
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]
],
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{
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},
{
"id": "DerHautarzt.60470744.eng.abstr-s7-t2",
"type": "umlsterm",
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},
{
"id": "DerHautarzt.60470744.eng.abstr-s7-t3",
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}
]
},
{
"id": "DerHautarzt.60470744.eng.abstr-s7-t4",
"type": "umlsterm",
"text": [
"Neotrombicula autumnalis"
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]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0041171"
}
]
}
] |
[] |
[] |
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DerHautarzt.60470749.eng.abstr
|
DerHautarzt.60470749.eng.abstr
|
[
{
"id": "DerHautarzt.60470749.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Drug-induced toxic epidermal necrolysis ( TEN ) is a rare but frequently lethal disease of the skin and mucosa of unknown etiology . Toxic metabolic and immunologic products in the serum have been discussed as possible causes . For this reason we have performed plasmapheresis on these patients for many years . Results regarding survival and healing of the lesions are quite favorable , as exemplified with two patients described here who benefited from the procedure despite their old age . In order to gain insight into possible disease mechanisms that would explain the beneficial effect of plasmapheresis , we did immunohistochemical studies on these patients before and in one case after the procedure . In dermis and epidermis , there was a striking increase of macrophages and a relative increase of CD8-positive lymphocytes which might act as cytotoxic effector cells ; these findings can be interpreted as the result of an immunological reaction . An increased staining of lesional epidermis with TNF , as previously noted by other autors , should be interpreted with caution since necrotic cells are involved . On the basis of the clinical results , the pathogenetic considerations , and in view of the lack of specific treatment modalities , clinical studies concerning plasmapheresis for the treatment of toxic epidermal necrolysis are recommended , particularly since this procedure is widely available and generally well tolerated ."
],
"offsets": [
[
0,
1447
]
]
}
] |
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DerHautarzt.60470754.eng.abstr
|
DerHautarzt.60470754.eng.abstr
|
[
{
"id": "DerHautarzt.60470754.eng.abstr-passage-0",
"type": "abstract",
"text": [
"For decades the results of elective lymph node dissection ( ELND ) are differently discussed , so that it is not definitely recommended at present the less so since the morbidity of this operation can ' t be neglected . Since the beginning of 1995 we practice a gamma-probe guided sentinel lymphonodectomy ( SLNE ) on patients with melanoma from a Breslow tumor thickness of 1 mm upward , after injecting a colloidal 99m-Tc labelled tin ( II ) - sulfid solution around the tumor or the scar , if the tumor has been excided before . By this method , that allows a selection of patients who according clinically to a stage I or II ( UICC ) but even histopathologically to a stage III and who are profiting of a removal of the regional lymph nodes , the sentinel node can be exactly localised , tissue-sparing removed at minimal complication rates and the completeness of the removal can be verified by measurements of the radioactivity . When finding metastases in the histopathological examination of the node a dissection of the whole region follows ."
],
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0,
1051
]
]
}
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] |
[] |
[] |
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] |
DerHautarzt.60470759.eng.abstr
|
DerHautarzt.60470759.eng.abstr
|
[
{
"id": "DerHautarzt.60470759.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Among 946 patients with nevus spilus we observed 5 patients ( 3 women and 2 men ) with transformations on it - 2 cases with malignant melanoma and 3 cases with spitz-nevus . Histologically the nevus spilus is a superficial variant on congenital pigmented nevus missing corial parts . Because of the risk of transformation a regular skin examination is advisable , a prophylactical excision of nevi spili as used in congenital pigmented nevi should be discussed ."
],
"offsets": [
[
0,
462
]
]
}
] |
[
{
"id": "DerHautarzt.60470759.eng.abstr-s1-t1",
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"patients"
],
"offsets": [
[
10,
18
]
],
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{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.60470759.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"nevus"
],
"offsets": [
[
24,
29
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027960"
}
]
},
{
"id": "DerHautarzt.60470759.eng.abstr-s1-t3",
"type": "umlsterm",
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"patients"
],
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[
51,
59
]
],
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{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.60470759.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"women"
],
"offsets": [
[
64,
69
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0043210"
}
]
},
{
"id": "DerHautarzt.60470759.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"men"
],
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[
76,
79
]
],
"normalized": [
{
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"db_id": "C0025266"
},
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}
]
},
{
"id": "DerHautarzt.60470759.eng.abstr-s1-t6",
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"text": [
"malignant"
],
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124,
133
]
],
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{
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}
]
},
{
"id": "DerHautarzt.60470759.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"melanoma"
],
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[
134,
142
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],
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}
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},
{
"id": "DerHautarzt.60470759.eng.abstr-s1-t8",
"type": "umlsterm",
"text": [
"malignant melanoma"
],
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124,
142
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],
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},
{
"id": "DerHautarzt.60470759.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"nevus"
],
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[
193,
198
]
],
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{
"db_name": "UMLS",
"db_id": "C0027960"
}
]
},
{
"id": "DerHautarzt.60470759.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"congenital"
],
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[
234,
244
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0009678"
}
]
},
{
"id": "DerHautarzt.60470759.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"nevus"
],
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[
255,
260
]
],
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{
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}
]
},
{
"id": "DerHautarzt.60470759.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"pigmented nevus"
],
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[
245,
260
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],
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{
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}
]
},
{
"id": "DerHautarzt.60470759.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"risk"
],
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[
299,
303
]
],
"normalized": [
{
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"db_id": "C0035647"
}
]
},
{
"id": "DerHautarzt.60470759.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"skin"
],
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[
332,
336
]
],
"normalized": [
{
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"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.60470759.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"nevi"
],
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[
393,
397
]
],
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"db_id": "C0027960"
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]
},
{
"id": "DerHautarzt.60470759.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"congenital"
],
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[
415,
425
]
],
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}
] |
[] |
[] |
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] |
DerHautarzt.60470767.eng.abstr
|
DerHautarzt.60470767.eng.abstr
|
[
{
"id": "DerHautarzt.60470767.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report on a patient with chronic discoid lupus erythematosus who was treated with argon-laser . The patient suffered from long-standing lesions and had been pretreated with various drugs , with no or slight improvement . After a few argon-laser applications , the treated skin lesions improved dramatically while the untreated lesional skin showed continuous disease activity . Histological and immunohistological investigations of biopsies from treated and untreated lesional skin suggest that endothelial mechanisms play a role in the generation and maintenance of discoid lesions in lupus erythematosus . This is the first reported case of successful treatment of chronic discoid skin lesions of a lupus erythematosus patient with argon-laser ."
],
"offsets": [
[
0,
750
]
]
}
] |
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}
] |
[] |
[] |
[
{
"id": "DerHautarzt.60470767.eng.abstr-s1-r1-t4.1-t2.3",
"type": "affects",
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DerHautarzt.60470771.eng.abstr
|
DerHautarzt.60470771.eng.abstr
|
[
{
"id": "DerHautarzt.60470771.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Mycobacterium gordonae is an atypical mycobacterium of very low pathogenic potential . It is widely distributed in soil and water and often detected on the mucous membranes of healthy persons . In recent years , there have been numerous reports of infections by M. gordonae in immunocompromised patients . In contrast , only four cases of skin infections by M. gordonae in immunocompetent patients have been published . We report on another patient without evidence of immunodeficiency who developed an atypical mycobacteriosis after a thorn injury during gardening . M. gordonae was isolated by tissue culture . The skin lesion cleared completely after treatment with doxycycline for three months ."
],
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[
0,
699
]
]
}
] |
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[] |
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DerHautarzt.60470776.eng.abstr
|
DerHautarzt.60470776.eng.abstr
|
[
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"type": "abstract",
"text": [
"Fabry's disease ( Angiokeratoma corporis diffusum ) is a rare X-chromosome linked recessive disorder belonging to the group of sphingolipoidoses . The basic defect involves the gene encoding alpha-galactosidase . Because this enzyme is responsible for decomposition of glycosphingolipids , its deficiency results in their accumulation in endothelial and smooth muscle cells . With time , generalized angiokeratomas , paresthesias , renal and cardiac insufficiency and cerebrovascular complications develop . We report a patient who in addition to the well-described findings also showed unique nail fold capillary changes not described so far . Analysis of serum concentration of alpha-galactosidase identified three female heterozygous carriers in the patient's family ."
],
"offsets": [
[
0,
771
]
]
}
] |
[
{
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8,
15
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{
"id": "DerHautarzt.60470776.eng.abstr-s1-t2",
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18,
31
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"id": "DerHautarzt.60470776.eng.abstr-s1-t3",
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92,
100
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},
{
"id": "DerHautarzt.60470776.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"Angiokeratoma corporis diffusum"
],
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[
18,
49
]
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},
{
"id": "DerHautarzt.60470776.eng.abstr-s2-t1",
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"text": [
"defect"
],
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157,
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},
{
"id": "DerHautarzt.60470776.eng.abstr-s2-t2",
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"text": [
"gene"
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[
177,
181
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],
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{
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}
]
},
{
"id": "DerHautarzt.60470776.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"alpha-galactosidase"
],
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[
191,
210
]
],
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{
"db_name": "UMLS",
"db_id": "C0002268"
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]
},
{
"id": "DerHautarzt.60470776.eng.abstr-s2-t4",
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"text": [
"alpha-galactosidase"
],
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[
191,
210
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],
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{
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"db_id": "C0023821"
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{
"db_name": "UMLS",
"db_id": "C0002245"
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{
"db_name": "UMLS",
"db_id": "C0002210"
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{
"db_name": "UMLS",
"db_id": "C0002211"
}
]
},
{
"id": "DerHautarzt.60470776.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"alpha-galactosidase"
],
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[
191,
210
]
],
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{
"db_name": "UMLS",
"db_id": "C0016955"
}
]
},
{
"id": "DerHautarzt.60470776.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"enzyme"
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[
226,
232
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"db_id": "C0014442"
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{
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]
},
{
"id": "DerHautarzt.60470776.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"glycosphingolipids"
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[
269,
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"db_id": "C0017978"
}
]
},
{
"id": "DerHautarzt.60470776.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"deficiency"
],
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[
294,
304
]
],
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{
"db_name": "UMLS",
"db_id": "C0011155"
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},
{
"id": "DerHautarzt.60470776.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"muscle"
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[
361,
367
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"db_id": "C0026845"
}
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},
{
"id": "DerHautarzt.60470776.eng.abstr-s3-t5",
"type": "umlsterm",
"text": [
"cells"
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[
368,
373
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}
]
},
{
"id": "DerHautarzt.60470776.eng.abstr-s3-t6",
"type": "umlsterm",
"text": [
"smooth muscle"
],
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[
354,
367
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],
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{
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"db_id": "C0026843"
}
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},
{
"id": "DerHautarzt.60470776.eng.abstr-s4-t1",
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"time"
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381,
385
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}
]
},
{
"id": "DerHautarzt.60470776.eng.abstr-s4-t2",
"type": "umlsterm",
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"angiokeratomas"
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400,
414
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},
{
"id": "DerHautarzt.60470776.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"complications"
],
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[
484,
497
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],
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{
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"db_id": "C0009566"
}
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},
{
"id": "DerHautarzt.60470776.eng.abstr-s5-t1",
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"patient"
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520,
527
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}
]
},
{
"id": "DerHautarzt.60470776.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"findings"
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566,
574
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},
{
"id": "DerHautarzt.60470776.eng.abstr-s5-t3",
"type": "umlsterm",
"text": [
"nail"
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[
594,
598
]
],
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{
"db_name": "UMLS",
"db_id": "C0027342"
}
]
},
{
"id": "DerHautarzt.60470776.eng.abstr-s5-t4",
"type": "umlsterm",
"text": [
"capillary"
],
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[
604,
613
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],
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}
]
},
{
"id": "DerHautarzt.60470776.eng.abstr-s6-t1",
"type": "umlsterm",
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"Analysis"
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645,
653
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]
},
{
"id": "DerHautarzt.60470776.eng.abstr-s6-t2",
"type": "umlsterm",
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663,
676
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],
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}
]
},
{
"id": "DerHautarzt.60470776.eng.abstr-s6-t3",
"type": "umlsterm",
"text": [
"alpha-galactosidase"
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680,
699
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},
{
"id": "DerHautarzt.60470776.eng.abstr-s6-t4",
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{
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{
"db_name": "UMLS",
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}
]
},
{
"id": "DerHautarzt.60470776.eng.abstr-s6-t5",
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"alpha-galactosidase"
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680,
699
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{
"id": "DerHautarzt.60470776.eng.abstr-s6-t6",
"type": "umlsterm",
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"female"
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},
{
"id": "DerHautarzt.60470776.eng.abstr-s6-t7",
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{
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}
]
},
{
"id": "DerHautarzt.60470776.eng.abstr-s6-t8",
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"family"
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763,
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]
],
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{
"db_name": "UMLS",
"db_id": "C0015576"
}
]
}
] |
[] |
[] |
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DerHautarzt.60470783.eng.abstr
|
DerHautarzt.60470783.eng.abstr
|
[
{
"id": "DerHautarzt.60470783.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A fourteen-year-old girl with acute otitis media died from gram positive sepsis and toxic shock despite intensive treatment . The definitive bacteriological results showed positive cultures for both S. aureus and S. pyogenes serotype A. In vitro the bacteria produced the bacterial superantigens TSST-1, enterotoxin A , enterotoxin C ( S. aureus ) and erythrogenic toxin C ( S. pyogenes ) . The patient presented with large flaccid sterile bullae on her chest and arms as well as necrotizing fasciitis . Tzanck test showed keratinozytes without necrosis and no inflammatory cells . Frozen-section and conventional skin biopsy specimens revealed subcorneal intraepidermal cleavage . These cytological and histological findings are those of staphylococcal scalded skin syndrome ( SSSS ) and differ from bullous erysipelas or toxic epidermal necrolysis ( TEN ) . Therefore bacterial exotoxins are most likely responsible for the intraepidermal blistering in our case just as in SSSS . Bullae are an unfavorable prognostic sign in gram positive toxic shock syndrome . Both Tzanck test and frozen-section biopsy are easy to perform and useful in the early and rapid recognition of gram positive bullous toxic shock syndrome ."
],
"offsets": [
[
0,
1220
]
]
}
] |
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DerHautarzt.60470817.eng.abstr
|
DerHautarzt.60470817.eng.abstr
|
[
{
"id": "DerHautarzt.60470817.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Type I allergies to latex have become an increasing problem in occupational dermatology during the past few years , especially since at least 10% of health care workers are affected . In the Department of Dermatology , University Erlangen-Nuremberg , a 12-fold increase in latex-allergic patients has been documented between 1989 and 1995 with a clear trend to more severe systemic manifestations ( from 10.7% in 1989/1990 to 44% in 1994/1995 ) . Among the water soluble proteins ( molecular weights 2 to 200 kD ) which may induce latex allergy , at least 5 are considered as main proteins with known primary structure . In addition some `marker' proteins seem to induce specific IgE antibodies in special risk groups ( e.g. 46 kD-protein in medical professions , 14.6 kD- and 27 kD-proteins in children with spina bifida ) . Cross reactions between latex and several fruits ( especially avocado , kiwi , banana and chestnut ) in 60 to 70% of latex-allergic patients have to be taken into account when evaluating and counselling affected patients . Most important in prophylaxis is the complete change to powder-free latex gloves in medical institutions , since these gloves usually have a low protein content . Our listing of surgical and examination gloves according to their protein content ( as measured by the modified Lowry- and High Pressure Liquid Chromatography method ) should be a useful guideline for the choice of suitable gloves ."
],
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[
0,
1444
]
]
}
] |
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DerHautarzt.60470825.eng.abstr
|
DerHautarzt.60470825.eng.abstr
|
[
{
"id": "DerHautarzt.60470825.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Photodynamic therapy ( PDT ) involving the sequential administration of photosensitizing drugs and light has a successful record in the treatment of superficial tumors . Recent investigations document not only cytotoxicity but also immunomodulatory effects of PDT . Cell type as well as state of activation and differentiation are among the parameters influencing susceptibility to PDT , thus allowing targeting of selected cell ( sub- ) populations . In addition to lasers , non-coherent light sources are also effective . These features , along with current clinical experience , suggest PDT as an interesting alternative to better established photochemotherapies in the treatment of widespread malignant and benign dermatoses ."
],
"offsets": [
[
0,
730
]
]
}
] |
[
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],
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13,
20
]
],
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},
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}
]
},
{
"id": "DerHautarzt.60470825.eng.abstr-s1-t2",
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"text": [
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],
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23,
26
]
],
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] |
[] |
[] |
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] |
DerHautarzt.60470832.eng.abstr
|
DerHautarzt.60470832.eng.abstr
|
[
{
"id": "DerHautarzt.60470832.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The purpose of this study was to determine whether 24 hour patch testing with 0.5% sodium lauryl sulphate ( SLS ) could reliably predict skin susceptibility to an irritant when compared with the alkali resistance test ( ART ) , a widely used method employing sodium hydroxide . After having given informed consent , 40 patients ( age range from 20 to 60 years ) with an active irritant contact dermatitis ( ICD ) , 40 patients in whom ICD had cleared , as well as 40 healthy volunteers serving as controls were tested . The skin responses to SLS were assessed both visually and by measurement of transepidermal water loss ( TEWL ) as an indicator of stratum corneum integrity . SLS significantly increased the erythema scores and TEWL in patients with healed ICD , and the increase of TEWL was even more pronounced in patients with active ICD . By contrast , a decrease in alkali resistance was found in patients with active ICD only but not in patients with healed ICD . The data obtained indicate that the SLS test , unlike ART , may provide a non-invasive tool predicting a possible constitutional skin susceptibility or indicating a subclinically impaired epidermal barrier function . However , because of the relatively high interindividual variation , a cut-clear statement concerning the skin susceptibility cannot be made by this test . On the other hand , the ART seems only to be useful for following and documenting the healing period following ICD ."
],
"offsets": [
[
0,
1461
]
]
}
] |
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{
"id": "DerHautarzt.60470832.eng.abstr-s1-t2",
"type": "umlsterm",
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"sodium"
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},
{
"id": "DerHautarzt.60470832.eng.abstr-s1-t3",
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"sulphate"
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"db_id": "C0038720"
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{
"id": "DerHautarzt.60470832.eng.abstr-s1-t4",
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"skin"
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"type": "umlsterm",
"text": [
"susceptibility"
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},
{
"id": "DerHautarzt.60470832.eng.abstr-s1-t6",
"type": "umlsterm",
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"irritant"
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},
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"id": "DerHautarzt.60470832.eng.abstr-s1-t7",
"type": "umlsterm",
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"alkali"
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},
{
"id": "DerHautarzt.60470832.eng.abstr-s1-t9",
"type": "umlsterm",
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"ART"
],
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}
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"id": "DerHautarzt.60470832.eng.abstr-s1-t10",
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"method"
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{
"id": "DerHautarzt.60470832.eng.abstr-s1-t11",
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"sodium"
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"id": "DerHautarzt.60470832.eng.abstr-s1-t12",
"type": "umlsterm",
"text": [
"hydroxide"
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"db_id": "C0220853"
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}
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},
{
"id": "DerHautarzt.60470832.eng.abstr-s1-t13",
"type": "umlsterm",
"text": [
"lauryl sulphate"
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[
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"db_name": "UMLS",
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DerHautarzt.60470839.eng.abstr
|
DerHautarzt.60470839.eng.abstr
|
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"id": "DerHautarzt.60470839.eng.abstr-passage-0",
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"text": [
"Patch testing as a part of the diagnostic evaluation of patients suffering from oral mucosal complaints or with symptoms where dental materials are suspected to be the cause is hampered by numerous difficulties . The ingredients of denture materials as well as their liberation in the oral cavity are often unknown . Contact with many of the potential ingredients of denture materials can occur on other occasions , as well , thus making it difficult to find out where the patient has acquired his or her sensitization . The special morphological and immunological situation in the oral mucosa may produce tolerance of substances which evoke a positive patch test reaction on the skin of the back . This paper introduces the possible spectrum of allergens in these patients and discusses the difficulties in the assessment of the relevance of positive patch test reactions . From August 1992 to July 1994 , 756 patients with complaints of the oral mucosa and/or suspected contact allergy to denture materials were patch tested in the departments of dermatology joining the Information Network of Departments of Dermatology in Germany ( IVDK ) . Among these patients , women were overrepresented , while individuals with atopic dermatitis were underrepresented . The allergen spectrum included amalgam , mercury compounds , gold salts , palladium chloride and methyl methacrylate . However , the epidemiological value of these data is limited . A second part of this paper will review the various groups of allergens ."
],
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0,
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]
]
}
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] |
DerHautarzt.60470844.eng.abstr
|
DerHautarzt.60470844.eng.abstr
|
[
{
"id": "DerHautarzt.60470844.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The problems in patch testing and relevance evaluation as well as the practical consequences are discussed for the most important groups of dental materials ( DM ) . These include metal alloys : amalgam with a low allergy prevalence ; palladium salts showing a high correlation with nickel allergy but a low one with metallic palladium or alloys ; the widespread allergen nickel is most relevant when dealing with nickel containing DM-alloys that are not corrosionresistant ; gold salts with widely differing test results and limited benefit to detect genuine gold intolerance . Among synthetic resins methylmethacrylate is the most important allergen because of the high frequency of exposition . With composite materials and other methacrylates , both cross reactions and active sensitization should be kept in mind . Relevant reactions due to additives are rare ; positive benzoylperoxide tests should be interpreted very critically . A number of DM may contain allergens of the etheric oils - colophonium - Peru-balsam group . DM should be tested with standardized methods only . As the dental consequences may be expensive , interpretation of such test results demands utmost care and special experience ."
],
"offsets": [
[
0,
1210
]
]
}
] |
[
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"id": "DerHautarzt.60470844.eng.abstr-s1-t1",
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"testing"
],
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22,
29
]
],
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"db_id": "C0039593"
}
]
},
{
"id": "DerHautarzt.60470844.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"evaluation"
],
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[
44,
54
]
],
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"db_id": "C0220825"
}
]
},
{
"id": "DerHautarzt.60470844.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"DM"
],
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[
159,
161
]
],
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{
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"db_id": "C0011633"
},
{
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"db_id": "C0011849"
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]
},
{
"id": "DerHautarzt.60470844.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"dental materials"
],
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140,
156
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"db_id": "C0011379"
}
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},
{
"id": "DerHautarzt.60470844.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"metal"
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185
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"db_id": "C0025552"
}
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},
{
"id": "DerHautarzt.60470844.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"alloys"
],
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]
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}
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},
{
"id": "DerHautarzt.60470844.eng.abstr-s2-t3",
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"text": [
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},
{
"id": "DerHautarzt.60470844.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"prevalence"
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"db_id": "C0220900"
},
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"db_id": "C0033105"
}
]
},
{
"id": "DerHautarzt.60470844.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"palladium"
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235,
244
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"db_id": "C0030230"
}
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},
{
"id": "DerHautarzt.60470844.eng.abstr-s2-t6",
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"text": [
"nickel"
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"id": "DerHautarzt.60470844.eng.abstr-s2-t7",
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}
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},
{
"id": "DerHautarzt.60470844.eng.abstr-s2-t8",
"type": "umlsterm",
"text": [
"palladium"
],
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326,
335
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}
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},
{
"id": "DerHautarzt.60470844.eng.abstr-s2-t9",
"type": "umlsterm",
"text": [
"alloys"
],
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339,
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},
{
"id": "DerHautarzt.60470844.eng.abstr-s2-t10",
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"text": [
"allergen"
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"db_id": "C0002092"
}
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},
{
"id": "DerHautarzt.60470844.eng.abstr-s2-t11",
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"text": [
"nickel"
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},
{
"id": "DerHautarzt.60470844.eng.abstr-s2-t12",
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"text": [
"nickel"
],
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414,
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},
{
"id": "DerHautarzt.60470844.eng.abstr-s2-t13",
"type": "umlsterm",
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},
{
"id": "DerHautarzt.60470844.eng.abstr-s2-t14",
"type": "umlsterm",
"text": [
"gold"
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]
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"id": "DerHautarzt.60470844.eng.abstr-s3-t1",
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"resins"
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{
"id": "DerHautarzt.60470844.eng.abstr-s3-t2",
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"text": [
"methylmethacrylate"
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"id": "DerHautarzt.60470844.eng.abstr-s7-r1-t2.1-t1.1",
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},
{
"id": "DerHautarzt.60470844.eng.abstr-s7-r3-t2.1-t1.2",
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"id": "DerHautarzt.60470844.eng.abstr-s7-r4-t1.1-t2.1",
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}
] |
DerHautarzt.60470854.eng.abstr
|
DerHautarzt.60470854.eng.abstr
|
[
{
"id": "DerHautarzt.60470854.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Malignant melanoma of the vulva is an uncommon disease . The amelanotic subtype is only rarely mentioned . We report a 60-year-old patient with a 6 month history of vulvar pruritus . Ivory lesions combined with erosions and fine `cigarette paper ' - like wrinkling were suspicious for lichen sclerosus et atrophicus . Histologically the diagnosis of an amelanotic malignant melanoma was made . Amelanotic melanoma may present with a wide variety of clinical features . Even in the uncommon location of the vulva , amelanotic melanoma should be suspected in any nonhealing nonpigmented lesion ."
],
"offsets": [
[
0,
593
]
]
}
] |
[
{
"id": "DerHautarzt.60470854.eng.abstr-s1-t1",
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"text": [
"Malignant"
],
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[
0,
9
]
],
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"db_id": "C0006826"
}
]
},
{
"id": "DerHautarzt.60470854.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"melanoma"
],
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[
10,
18
]
],
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{
"db_name": "UMLS",
"db_id": "C0025202"
}
]
},
{
"id": "DerHautarzt.60470854.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"vulva"
],
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[
26,
31
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0042993"
},
{
"db_name": "UMLS",
"db_id": "C0375071"
}
]
},
{
"id": "DerHautarzt.60470854.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"disease"
],
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[
47,
54
]
],
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{
"db_name": "UMLS",
"db_id": "C0012634"
}
]
},
{
"id": "DerHautarzt.60470854.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"Malignant melanoma"
],
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[
0,
18
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0025202"
}
]
},
{
"id": "DerHautarzt.60470854.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"patient"
],
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[
131,
138
]
],
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{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.60470854.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"history"
],
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[
154,
161
]
],
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{
"db_name": "UMLS",
"db_id": "C0019664"
},
{
"db_name": "UMLS",
"db_id": "C0019665"
}
]
},
{
"id": "DerHautarzt.60470854.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"pruritus"
],
"offsets": [
[
172,
180
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0033778"
},
{
"db_name": "UMLS",
"db_id": "C0033774"
}
]
},
{
"id": "DerHautarzt.60470854.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"paper"
],
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[
240,
245
]
],
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{
"db_name": "UMLS",
"db_id": "C0030351"
}
]
},
{
"id": "DerHautarzt.60470854.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"lichen"
],
"offsets": [
[
285,
291
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0023657"
}
]
},
{
"id": "DerHautarzt.60470854.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"lichen sclerosus"
],
"offsets": [
[
285,
301
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0023652"
}
]
},
{
"id": "DerHautarzt.60470854.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"diagnosis"
],
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[
337,
346
]
],
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{
"db_name": "UMLS",
"db_id": "C0011900"
},
{
"db_name": "UMLS",
"db_id": "C0348026"
}
]
},
{
"id": "DerHautarzt.60470854.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"malignant"
],
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[
364,
373
]
],
"normalized": [
{
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"db_id": "C0006826"
}
]
},
{
"id": "DerHautarzt.60470854.eng.abstr-s5-t3",
"type": "umlsterm",
"text": [
"melanoma"
],
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[
374,
382
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0025202"
}
]
},
{
"id": "DerHautarzt.60470854.eng.abstr-s5-t4",
"type": "umlsterm",
"text": [
"malignant melanoma"
],
"offsets": [
[
364,
382
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0025202"
}
]
},
{
"id": "DerHautarzt.60470854.eng.abstr-s6-t1",
"type": "umlsterm",
"text": [
"melanoma"
],
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[
405,
413
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0025202"
}
]
},
{
"id": "DerHautarzt.60470854.eng.abstr-s6-t2",
"type": "umlsterm",
"text": [
"Amelanotic melanoma"
],
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[
394,
413
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0206735"
}
]
},
{
"id": "DerHautarzt.60470854.eng.abstr-s7-t1",
"type": "umlsterm",
"text": [
"vulva"
],
"offsets": [
[
506,
511
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0042993"
},
{
"db_name": "UMLS",
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}
]
},
{
"id": "DerHautarzt.60470854.eng.abstr-s7-t2",
"type": "umlsterm",
"text": [
"melanoma"
],
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[
525,
533
]
],
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{
"db_name": "UMLS",
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}
]
},
{
"id": "DerHautarzt.60470854.eng.abstr-s7-t3",
"type": "umlsterm",
"text": [
"amelanotic melanoma"
],
"offsets": [
[
514,
533
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0206735"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.60470854.eng.abstr-s1-r1-t3.1-t3.2",
"type": "location_of",
"arg1_id": "DerHautarzt.60470854.eng.abstr-s7-t3",
"arg2_id": "DerHautarzt.60470854.eng.abstr-s3-t3",
"normalized": []
},
{
"id": "DerHautarzt.60470854.eng.abstr-s1-r2-t3.2-t5.1",
"type": "degree_of",
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"arg2_id": "DerHautarzt.60470854.eng.abstr-s1-t5",
"normalized": []
},
{
"id": "DerHautarzt.60470854.eng.abstr-s1-r3-t3.2-t1.1",
"type": "degree_of",
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"arg2_id": "DerHautarzt.60470854.eng.abstr-s7-t1",
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},
{
"id": "DerHautarzt.60470854.eng.abstr-s1-r4-t3.1-t5.1",
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},
{
"id": "DerHautarzt.60470854.eng.abstr-s1-r5-t3.1-t1.1",
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},
{
"id": "DerHautarzt.60470854.eng.abstr-s3-r1-t1.1-t2.2",
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"arg2_id": "DerHautarzt.60470854.eng.abstr-s3-t2",
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},
{
"id": "DerHautarzt.60470854.eng.abstr-s3-r2-t1.1-t2.1",
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"arg2_id": "DerHautarzt.60470854.eng.abstr-s7-t2",
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},
{
"id": "DerHautarzt.60470854.eng.abstr-s3-r3-t2.2-t2.1",
"type": "issue_in",
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"arg2_id": "DerHautarzt.60470854.eng.abstr-s7-t2",
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},
{
"id": "DerHautarzt.60470854.eng.abstr-s3-r4-t2.2-t1.1",
"type": "occurs_in",
"arg1_id": "DerHautarzt.60470854.eng.abstr-s3-t2",
"arg2_id": "DerHautarzt.60470854.eng.abstr-s7-t1",
"normalized": []
},
{
"id": "DerHautarzt.60470854.eng.abstr-s3-r5-t3.2-t2.2",
"type": "associated_with",
"arg1_id": "DerHautarzt.60470854.eng.abstr-s3-t3",
"arg2_id": "DerHautarzt.60470854.eng.abstr-s3-t2",
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},
{
"id": "DerHautarzt.60470854.eng.abstr-s3-r6-t3.2-t2.1",
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},
{
"id": "DerHautarzt.60470854.eng.abstr-s3-r7-t2.2-t3.2",
"type": "associated_with",
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"arg2_id": "DerHautarzt.60470854.eng.abstr-s3-t3",
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},
{
"id": "DerHautarzt.60470854.eng.abstr-s4-r1-t3.1-t2.1",
"type": "affects",
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"arg2_id": "DerHautarzt.60470854.eng.abstr-s7-t2",
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},
{
"id": "DerHautarzt.60470854.eng.abstr-s4-r2-t1.1-t3.1",
"type": "causes",
"arg1_id": "DerHautarzt.60470854.eng.abstr-s7-t1",
"arg2_id": "DerHautarzt.60470854.eng.abstr-s7-t3",
"normalized": []
},
{
"id": "DerHautarzt.60470854.eng.abstr-s5-r1-t1.1-t4.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.60470854.eng.abstr-s7-t1",
"arg2_id": "DerHautarzt.60470854.eng.abstr-s5-t4",
"normalized": []
},
{
"id": "DerHautarzt.60470854.eng.abstr-s5-r3-t1.1-t2.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.60470854.eng.abstr-s7-t1",
"arg2_id": "DerHautarzt.60470854.eng.abstr-s7-t2",
"normalized": []
},
{
"id": "DerHautarzt.60470854.eng.abstr-s7-r1-t1.1-t3.1",
"type": "location_of",
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"arg2_id": "DerHautarzt.60470854.eng.abstr-s7-t3",
"normalized": []
}
] |
DerHautarzt.60470858.eng.abstr
|
DerHautarzt.60470858.eng.abstr
|
[
{
"id": "DerHautarzt.60470858.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Palmoplantar keratodermia ( PPK ) varians and PPK punctata are considered different entities within the group of hereditary palmoplantar keratodermas . Keratosis punctata of the palmar creases constitutes a localized form of keratodermia palmoplantaris punctata . We describe a 31-year-old man exhibiting both nummular and papular keratoses on the soles , as well as small punctate keratoses confined to the palmar creases . In view of the co-occurrence of these two types of PPK , the question arises whether keratosis palmoplantaris of the varians and the punctate type represent distinct entities or represent variable manifestations of the same gene defect ."
],
"offsets": [
[
0,
662
]
]
}
] |
[
{
"id": "DerHautarzt.60470858.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"Keratosis"
],
"offsets": [
[
152,
161
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0022593"
}
]
},
{
"id": "DerHautarzt.60470858.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"form"
],
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[
217,
221
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0376315"
}
]
},
{
"id": "DerHautarzt.60470858.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"man"
],
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[
290,
293
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0025266"
},
{
"db_name": "UMLS",
"db_id": "C0024554"
}
]
},
{
"id": "DerHautarzt.60470858.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"keratoses"
],
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[
331,
340
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0022593"
}
]
},
{
"id": "DerHautarzt.60470858.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"soles"
],
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[
348,
353
]
],
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{
"db_name": "UMLS",
"db_id": "C0037613"
}
]
},
{
"id": "DerHautarzt.60470858.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"keratoses"
],
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[
382,
391
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0022593"
}
]
},
{
"id": "DerHautarzt.60470858.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"co-occurrence"
],
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[
440,
453
]
],
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{
"db_name": "UMLS",
"db_id": "C0243132"
}
]
},
{
"id": "DerHautarzt.60470858.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"keratosis"
],
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[
510,
519
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0022593"
}
]
},
{
"id": "DerHautarzt.60470858.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"gene"
],
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[
649,
653
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0017337"
}
]
},
{
"id": "DerHautarzt.60470858.eng.abstr-s4-t4",
"type": "umlsterm",
"text": [
"defect"
],
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[
654,
660
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0243067"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.60470858.eng.abstr-s2-r1-t2.1-t1.1",
"type": "causes",
"arg1_id": "DerHautarzt.60470858.eng.abstr-s4-t2",
"arg2_id": "DerHautarzt.60470858.eng.abstr-s4-t1",
"normalized": []
},
{
"id": "DerHautarzt.60470858.eng.abstr-s3-r1-t3.1-t1.2",
"type": "associated_with",
"arg1_id": "DerHautarzt.60470858.eng.abstr-s4-t3",
"arg2_id": "DerHautarzt.60470858.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "DerHautarzt.60470858.eng.abstr-s3-r2-t1.2-t3.1",
"type": "property_of",
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"arg2_id": "DerHautarzt.60470858.eng.abstr-s4-t3",
"normalized": []
},
{
"id": "DerHautarzt.60470858.eng.abstr-s3-r3-t1.2-t3.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.60470858.eng.abstr-s3-t1",
"arg2_id": "DerHautarzt.60470858.eng.abstr-s4-t3",
"normalized": []
},
{
"id": "DerHautarzt.60470858.eng.abstr-s3-r4-t3.1-t1.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.60470858.eng.abstr-s4-t3",
"arg2_id": "DerHautarzt.60470858.eng.abstr-s4-t1",
"normalized": []
},
{
"id": "DerHautarzt.60470858.eng.abstr-s3-r5-t1.2-t3.1",
"type": "affects",
"arg1_id": "DerHautarzt.60470858.eng.abstr-s3-t1",
"arg2_id": "DerHautarzt.60470858.eng.abstr-s4-t3",
"normalized": []
},
{
"id": "DerHautarzt.60470858.eng.abstr-s3-r6-t1.2-t1.1",
"type": "associated_with",
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"arg2_id": "DerHautarzt.60470858.eng.abstr-s4-t1",
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},
{
"id": "DerHautarzt.60470858.eng.abstr-s3-r7-t1.1-t1.2",
"type": "associated_with",
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"arg2_id": "DerHautarzt.60470858.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "DerHautarzt.60470858.eng.abstr-s3-r8-t1.1-t3.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.60470858.eng.abstr-s4-t1",
"arg2_id": "DerHautarzt.60470858.eng.abstr-s4-t3",
"normalized": []
},
{
"id": "DerHautarzt.60470858.eng.abstr-s4-r1-t3.1-t1.1",
"type": "location_of",
"arg1_id": "DerHautarzt.60470858.eng.abstr-s4-t3",
"arg2_id": "DerHautarzt.60470858.eng.abstr-s4-t1",
"normalized": []
}
] |
DerHautarzt.60470863.eng.abstr
|
DerHautarzt.60470863.eng.abstr
|
[
{
"id": "DerHautarzt.60470863.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 70-year-old patient developed Mycobacterium chelonae infection at a donor vein graft site following cardiac bypass surgery . The infection presented as fibrinous , necrotic ulcerations in the scar area . Mycobacterium chelonae and mycobacterium fortuitum are atypical mycobacteria and have been described previously causing infections after injections or surgical procedures . Infection of donor vein graft site is a rare complication after cardiac surgery . As mycobacterium chelonae cannot be cultivated on normal culture media , delayed wound healing might be disinterpretated as a primary wound healing disorder . Treatment of atypical myobacteriosis includes antibiotics , local heat therapy and surgical excision . Clarithromycin is the antibiotic of choice . We obtained complete healing after two months of Clarithromycin treatment , combined with heat therapy ."
],
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[] |
[] |
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DerHautarzt.60470901.eng.abstr
|
DerHautarzt.60470901.eng.abstr
|
[
{
"id": "DerHautarzt.60470901.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Although intolerance reactions to analgesics are not uncommon , there is still a lack of standardized procedures to diagnose the problem . We retrospectively analyzed results of scratch tests as well as oral challenges with analgesics in order to evaluate risk and diagnostic relevance of these procedures . In 1987-1992 a total of 650 patients with supposed intolerance to drugs were tested by oral challenge . Among them were 98 patients with a positive history of intolerance to non-aspirin analgesics . In 56 patients the intolerance could be verfied by oral challenge . In order of decreasing frequency , the most likely agents were propyphenazone , diclofenac , metamizole , ibuprofen , carbamazepine , indomethacin , phenazone ( antipyrine ) , and paracetamol ( acetaminophen ) . Oral provocation showed clear dose-response relationships . For propyphenazone , the half-effective provocation dose was the same for all symptoms ( cutaneous , nasal , bronchial , anaphylactoid ) . Scratch testing was not of diagnostic significance . Standardized test protocols starting with low dose oral challenges are suitable and helpful in minimizing the risk of severe side effects ."
],
"offsets": [
[
0,
1178
]
]
}
] |
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},
{
"id": "DerHautarzt.60470901.eng.abstr-s6-t10",
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"paracetamol"
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{
"id": "DerHautarzt.60470901.eng.abstr-s6-t11",
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"id": "DerHautarzt.60470901.eng.abstr-s8-t2",
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"id": "DerHautarzt.60470901.eng.abstr-s9-t2",
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]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.60470901.eng.abstr-s4-r1-t1.1-t2.2",
"type": "uses",
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},
{
"id": "DerHautarzt.60470901.eng.abstr-s4-r2-t2.2-t2.1",
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"id": "DerHautarzt.60470901.eng.abstr-s4-r3-t1.1-t2.1",
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},
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"id": "DerHautarzt.60470901.eng.abstr-s4-r4-t4.1-t2.2",
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},
{
"id": "DerHautarzt.60470901.eng.abstr-s4-r5-t2.2-t4.1",
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},
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"id": "DerHautarzt.60470901.eng.abstr-s8-r1-t1.1-t2.1",
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"id": "DerHautarzt.60470901.eng.abstr-s10-r1-t1.1-t4.1",
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{
"id": "DerHautarzt.60470901.eng.abstr-s10-r2-t1.1-t4.1",
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},
{
"id": "DerHautarzt.60470901.eng.abstr-s10-r4-t1.1-t4.1",
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}
] |
DerHautarzt.60470909.eng.abstr
|
DerHautarzt.60470909.eng.abstr
|
[
{
"id": "DerHautarzt.60470909.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We have seen 4 patients in 1995 who showed erysipelas in the leg used for vein graft harvesting for coronary bypass surgery . None of the patients had experienced erysipelas prior to surgery . One patient had his first attack erysipelas while the others experienced recurrent disease . Venectomy puts these patients at risk for later erysipelas . Therefore careful foot hygiene , eradication of mycotic infections and adequate therapy for initial erysipelas are mandatory in cardiac high risk patients after coronary bypass surgery ."
],
"offsets": [
[
0,
533
]
]
}
] |
[
{
"id": "DerHautarzt.60470909.eng.abstr-s1-t1",
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"patients"
],
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15,
23
]
],
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{
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"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.60470909.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"erysipelas"
],
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[
43,
53
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0014733"
}
]
},
{
"id": "DerHautarzt.60470909.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"leg"
],
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[
61,
64
]
],
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{
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"db_id": "C0023216"
}
]
},
{
"id": "DerHautarzt.60470909.eng.abstr-s1-t4",
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"text": [
"vein"
],
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[
74,
78
]
],
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{
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"db_id": "C0042449"
}
]
},
{
"id": "DerHautarzt.60470909.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"graft"
],
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[
79,
84
]
],
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{
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"db_id": "C0332835"
},
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}
]
},
{
"id": "DerHautarzt.60470909.eng.abstr-s1-t6",
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"surgery"
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116,
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]
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{
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}
]
},
{
"id": "DerHautarzt.60470909.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"coronary bypass"
],
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100,
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}
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},
{
"id": "DerHautarzt.60470909.eng.abstr-s1-t8",
"type": "umlsterm",
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100,
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}
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{
"id": "DerHautarzt.60470909.eng.abstr-s2-t1",
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"patients"
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138,
146
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{
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}
]
},
{
"id": "DerHautarzt.60470909.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"erysipelas"
],
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[
163,
173
]
],
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"db_id": "C0014733"
}
]
},
{
"id": "DerHautarzt.60470909.eng.abstr-s2-t3",
"type": "umlsterm",
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"surgery"
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183,
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}
]
},
{
"id": "DerHautarzt.60470909.eng.abstr-s3-t1",
"type": "umlsterm",
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"patient"
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}
]
},
{
"id": "DerHautarzt.60470909.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"erysipelas"
],
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226,
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}
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},
{
"id": "DerHautarzt.60470909.eng.abstr-s3-t3",
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}
]
},
{
"id": "DerHautarzt.60470909.eng.abstr-s4-t1",
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],
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]
},
{
"id": "DerHautarzt.60470909.eng.abstr-s4-t2",
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319,
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},
{
"id": "DerHautarzt.60470909.eng.abstr-s4-t3",
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334,
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},
{
"id": "DerHautarzt.60470909.eng.abstr-s5-t1",
"type": "umlsterm",
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"foot"
],
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365,
369
]
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}
]
},
{
"id": "DerHautarzt.60470909.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"hygiene"
],
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370,
377
]
],
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"db_id": "C0020405"
}
]
},
{
"id": "DerHautarzt.60470909.eng.abstr-s5-t3",
"type": "umlsterm",
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"infections"
],
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[
403,
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]
],
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"db_id": "C0021311"
}
]
},
{
"id": "DerHautarzt.60470909.eng.abstr-s5-t4",
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"therapy"
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427,
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{
"db_name": "UMLS",
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}
]
},
{
"id": "DerHautarzt.60470909.eng.abstr-s5-t5",
"type": "umlsterm",
"text": [
"erysipelas"
],
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447,
457
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],
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"db_name": "UMLS",
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}
]
},
{
"id": "DerHautarzt.60470909.eng.abstr-s5-t6",
"type": "umlsterm",
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488,
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},
{
"id": "DerHautarzt.60470909.eng.abstr-s5-t7",
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"patients"
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}
]
},
{
"id": "DerHautarzt.60470909.eng.abstr-s5-t8",
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]
},
{
"id": "DerHautarzt.60470909.eng.abstr-s5-t9",
"type": "umlsterm",
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}
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},
{
"id": "DerHautarzt.60470909.eng.abstr-s5-t10",
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}
]
},
{
"id": "DerHautarzt.60470909.eng.abstr-s5-t11",
"type": "umlsterm",
"text": [
"coronary bypass surgery"
],
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[
508,
531
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0010055"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.60470909.eng.abstr-s1-r1-t6.2-t5.2",
"type": "method_of",
"arg1_id": "DerHautarzt.60470909.eng.abstr-s1-t6",
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},
{
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},
{
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"arg2_id": "DerHautarzt.60470909.eng.abstr-s5-t1",
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},
{
"id": "DerHautarzt.60470909.eng.abstr-s1-r4-t4.1-t8.1",
"type": "location_of",
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},
{
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"type": "method_of",
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},
{
"id": "DerHautarzt.60470909.eng.abstr-s1-r6-t6.2-t1.1",
"type": "affects",
"arg1_id": "DerHautarzt.60470909.eng.abstr-s1-t6",
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},
{
"id": "DerHautarzt.60470909.eng.abstr-s1-r7-t1.1-t5.2",
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{
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{
"id": "DerHautarzt.60470909.eng.abstr-s1-r9-t4.1-t5.1",
"type": "surrounds",
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},
{
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{
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{
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},
{
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},
{
"id": "DerHautarzt.60470909.eng.abstr-s1-r14-t3.1-t4.1",
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"arg2_id": "DerHautarzt.60470909.eng.abstr-s5-t4",
"normalized": []
},
{
"id": "DerHautarzt.60470909.eng.abstr-s1-r15-t5.1-t5.2",
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"id": "DerHautarzt.60470909.eng.abstr-s5-r46-t4.1-t2.1",
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}
] |
DerHautarzt.60470913.eng.abstr
|
DerHautarzt.60470913.eng.abstr
|
[
{
"id": "DerHautarzt.60470913.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Based on molecular data , the genus Trichosporon was recently reclassified . Six human pathogenic species , which are closely related to specific types of infections can be differentiated . By means of commercial test systems and simple key criteria according to Gueho et al. [ 15 ] , 44 isolates that had been identified as Tr . cutaneum between 7/92 and 1/96 , were reclassified . The evaluation of clinical data also included 66 isolates that had not been preserved , and 27 strains of Tr . inkin . Trichosporon species were found in 4.8% of all yeast isolates ( 3.8% Tr . cutaneum , 1% Tr . inkin ) . Nearly every other isolate of Tr . cutaneum was cultivated from nail material , while Tr . inkin was mainly isolated from skin in the anogenital region . In 38 cases , reclassification revealed Tr . mucoides ; Tr . ovoides and Tr . asteroides were identified in 3 cases each , while Tr . asahii , an especially remarkable pathogen in systemic mycoses , was not found . Clinically , isolates of Tr . mucoides were predominant in toenail mycoses which might be considered in the therapy of onychomycosis . Furthermore , isolates from the skin should be evaluated with respect to the increasing incidence of systemic Trichopsoron mycoses ."
],
"offsets": [
[
0,
1241
]
]
}
] |
[
{
"id": "DerHautarzt.60470913.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"Trichosporon"
],
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36,
48
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],
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"db_id": "C0040943"
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]
},
{
"id": "DerHautarzt.60470913.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"human"
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81,
86
]
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"db_id": "C0020114"
}
]
},
{
"id": "DerHautarzt.60470913.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"infections"
],
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[
155,
165
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{
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"db_id": "C0021311"
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},
{
"id": "DerHautarzt.60470913.eng.abstr-s3-t1",
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"text": [
"test"
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213,
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{
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"db_id": "C0076174"
}
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},
{
"id": "DerHautarzt.60470913.eng.abstr-s3-t2",
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"text": [
"criteria"
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241,
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"db_id": "C0243161"
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{
"id": "DerHautarzt.60470913.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"evaluation"
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387,
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}
]
},
{
"id": "DerHautarzt.60470913.eng.abstr-s5-t2",
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"text": [
"strains"
],
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478,
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],
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{
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"db_id": "C0080194"
}
]
},
{
"id": "DerHautarzt.60470913.eng.abstr-s6-t1",
"type": "umlsterm",
"text": [
"inkin"
],
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[
494,
499
]
],
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{
"db_name": "UMLS",
"db_id": "C0021510"
}
]
},
{
"id": "DerHautarzt.60470913.eng.abstr-s7-t1",
"type": "umlsterm",
"text": [
"Trichosporon"
],
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502,
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}
]
},
{
"id": "DerHautarzt.60470913.eng.abstr-s7-t2",
"type": "umlsterm",
"text": [
"yeast"
],
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549,
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]
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"db_id": "C0043393"
}
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},
{
"id": "DerHautarzt.60470913.eng.abstr-s9-t1",
"type": "umlsterm",
"text": [
"inkin"
],
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595,
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{
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"db_id": "C0021510"
}
]
},
{
"id": "DerHautarzt.60470913.eng.abstr-s11-t1",
"type": "umlsterm",
"text": [
"nail"
],
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669,
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]
],
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{
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"db_id": "C0027342"
}
]
},
{
"id": "DerHautarzt.60470913.eng.abstr-s12-t1",
"type": "umlsterm",
"text": [
"inkin"
],
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696,
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}
]
},
{
"id": "DerHautarzt.60470913.eng.abstr-s12-t2",
"type": "umlsterm",
"text": [
"skin"
],
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727,
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}
]
},
{
"id": "DerHautarzt.60470913.eng.abstr-s12-t3",
"type": "umlsterm",
"text": [
"anogenital region"
],
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739,
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],
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"db_id": "C0031066"
}
]
},
{
"id": "DerHautarzt.60470913.eng.abstr-s17-t1",
"type": "umlsterm",
"text": [
"mycoses"
],
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948,
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]
},
{
"id": "DerHautarzt.60470913.eng.abstr-s19-t1",
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"mycoses"
],
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1041,
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],
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}
]
},
{
"id": "DerHautarzt.60470913.eng.abstr-s19-t2",
"type": "umlsterm",
"text": [
"therapy"
],
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1082,
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"db_id": "C0039798"
}
]
},
{
"id": "DerHautarzt.60470913.eng.abstr-s19-t3",
"type": "umlsterm",
"text": [
"onychomycosis"
],
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1093,
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],
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]
},
{
"id": "DerHautarzt.60470913.eng.abstr-s20-t1",
"type": "umlsterm",
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"skin"
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1141,
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]
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}
]
},
{
"id": "DerHautarzt.60470913.eng.abstr-s20-t2",
"type": "umlsterm",
"text": [
"incidence"
],
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1197,
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"db_id": "C0220856"
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}
]
},
{
"id": "DerHautarzt.60470913.eng.abstr-s20-t3",
"type": "umlsterm",
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"mycoses"
],
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1232,
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}
]
},
{
"id": "DerHautarzt.60470913.eng.abstr-s20-t4",
"type": "umlsterm",
"text": [
"increasing incidence"
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1186,
1206
]
],
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{
"db_name": "UMLS",
"db_id": "C0220888"
}
]
}
] |
[] |
[] |
[
{
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"type": "associated_with",
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},
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"id": "DerHautarzt.60470913.eng.abstr-s12-r1-t2.1-t3.1",
"type": "adjacent_to",
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"id": "DerHautarzt.60470913.eng.abstr-s19-r1-t2.1-t1.1",
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},
{
"id": "DerHautarzt.60470913.eng.abstr-s19-r2-t1.1-t2.1",
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{
"id": "DerHautarzt.60470913.eng.abstr-s20-r1-t1.1-t4.1",
"type": "isa",
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},
{
"id": "DerHautarzt.60470913.eng.abstr-s20-r2-t1.1-t3.1",
"type": "location_of",
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{
"id": "DerHautarzt.60470913.eng.abstr-s20-r3-t1.1-t3.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.60470913.eng.abstr-s20-t1",
"arg2_id": "DerHautarzt.60470913.eng.abstr-s20-t3",
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},
{
"id": "DerHautarzt.60470913.eng.abstr-s20-r4-t3.1-t1.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.60470913.eng.abstr-s20-t3",
"arg2_id": "DerHautarzt.60470913.eng.abstr-s20-t1",
"normalized": []
}
] |
DerHautarzt.60470921.eng.abstr
|
DerHautarzt.60470921.eng.abstr
|
[
{
"id": "DerHautarzt.60470921.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Rheumatoid neutrophilic dermatitis is a rare dermatologic disorder seen in patients with active rheumatoid arthritis . Clinically firm erythematous 3-5 mm papules are found mainly on the arms , the hips and the proximal thighs . The lesions may be pruritic leading to excoriations and crusts . Histology reveals a dense dermal infiltrate with neutrophilic granulocytes , while leukocytoclasia may be seen , vasculitits is not observed . This overview of rheumatoid neutrophilic dermatitis may help remind the practioner to include this uncommon disorder in the differential diagnosis of rheumatoid arthritis-related dermatoses ."
],
"offsets": [
[
0,
628
]
]
}
] |
[
{
"id": "DerHautarzt.60470921.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"dermatitis"
],
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24,
34
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],
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"db_id": "C0011603"
}
]
},
{
"id": "DerHautarzt.60470921.eng.abstr-s1-t2",
"type": "umlsterm",
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"disorder"
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58,
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"db_name": "UMLS",
"db_id": "C0012634"
}
]
},
{
"id": "DerHautarzt.60470921.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"patients"
],
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]
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"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.60470921.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"arthritis"
],
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[
107,
116
]
],
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{
"db_name": "UMLS",
"db_id": "C0003864"
}
]
},
{
"id": "DerHautarzt.60470921.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"dermatologic disorder"
],
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[
45,
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]
],
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"db_name": "UMLS",
"db_id": "C0037274"
}
]
},
{
"id": "DerHautarzt.60470921.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"rheumatoid arthritis"
],
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96,
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],
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"db_name": "UMLS",
"db_id": "C0003873"
}
]
},
{
"id": "DerHautarzt.60470921.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"arms"
],
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187,
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]
],
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"db_id": "C0003792"
}
]
},
{
"id": "DerHautarzt.60470921.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"hips"
],
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198,
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]
],
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{
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"db_id": "C0019552"
}
]
},
{
"id": "DerHautarzt.60470921.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"thighs"
],
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220,
226
]
],
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{
"db_name": "UMLS",
"db_id": "C0039866"
}
]
},
{
"id": "DerHautarzt.60470921.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"Histology"
],
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294,
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"db_id": "C0019638"
},
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"db_id": "C0205462"
}
]
},
{
"id": "DerHautarzt.60470921.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"granulocytes"
],
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"db_id": "C0018183"
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{
"id": "DerHautarzt.60470921.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"neutrophilic granulocytes"
],
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[
343,
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],
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"db_name": "UMLS",
"db_id": "C0027950"
}
]
},
{
"id": "DerHautarzt.60470921.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"dermatitis"
],
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478,
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"db_id": "C0011603"
}
]
},
{
"id": "DerHautarzt.60470921.eng.abstr-s5-t2",
"type": "umlsterm",
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"disorder"
],
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545,
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"db_id": "C0012634"
}
]
},
{
"id": "DerHautarzt.60470921.eng.abstr-s5-t3",
"type": "umlsterm",
"text": [
"diagnosis"
],
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"db_id": "C0348026"
}
]
},
{
"id": "DerHautarzt.60470921.eng.abstr-s5-t4",
"type": "umlsterm",
"text": [
"arthritis-related"
],
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598,
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"db_id": "C0003864"
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},
{
"id": "DerHautarzt.60470921.eng.abstr-s5-t5",
"type": "umlsterm",
"text": [
"dermatoses"
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616,
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},
{
"id": "DerHautarzt.60470921.eng.abstr-s5-t6",
"type": "umlsterm",
"text": [
"differential diagnosis"
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561,
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"db_id": "C0220820"
},
{
"db_name": "UMLS",
"db_id": "C0011906"
}
]
}
] |
[] |
[] |
[
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"type": "issue_in",
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{
"id": "DerHautarzt.60470921.eng.abstr-s4-r2-t1.2-t1.1",
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},
{
"id": "DerHautarzt.60470921.eng.abstr-s5-r1-t6.1-t5.1",
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},
{
"id": "DerHautarzt.60470921.eng.abstr-s5-r2-t6.1-t3.2",
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] |
DerHautarzt.60470927.eng.abstr
|
DerHautarzt.60470927.eng.abstr
|
[
{
"id": "DerHautarzt.60470927.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 31-year-old Turkish patient and some family members suffered from multiple hyperplastic oral mucosal papules . Intralesional papilloma virus was not found but the patient had elevated levels of CD8 lymphocytes in his peripheral blood . We diagnosed focal epithelial hyperplasia of Heck ."
],
"offsets": [
[
0,
289
]
]
}
] |
[
{
"id": "DerHautarzt.60470927.eng.abstr-s1-t1",
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"patient"
],
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[
22,
29
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.60470927.eng.abstr-s1-t2",
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"family"
],
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[
39,
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]
],
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{
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}
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},
{
"id": "DerHautarzt.60470927.eng.abstr-s1-t3",
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"family members"
],
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[
39,
53
]
],
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{
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"db_id": "C0086282"
}
]
},
{
"id": "DerHautarzt.60470927.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"papilloma"
],
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[
127,
136
]
],
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{
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"db_id": "C0030354"
},
{
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}
]
},
{
"id": "DerHautarzt.60470927.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"virus"
],
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137,
142
]
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}
]
},
{
"id": "DerHautarzt.60470927.eng.abstr-s2-t3",
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"patient"
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165,
172
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}
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},
{
"id": "DerHautarzt.60470927.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"CD8"
],
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[
196,
199
]
],
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{
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"db_id": "C0085358"
}
]
},
{
"id": "DerHautarzt.60470927.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"lymphocytes"
],
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[
200,
211
]
],
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{
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"db_id": "C0024264"
}
]
},
{
"id": "DerHautarzt.60470927.eng.abstr-s2-t6",
"type": "umlsterm",
"text": [
"blood"
],
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[
230,
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],
"normalized": [
{
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"db_id": "C0005767"
},
{
"db_name": "UMLS",
"db_id": "C0005768"
},
{
"db_name": "UMLS",
"db_id": "C0005835"
}
]
},
{
"id": "DerHautarzt.60470927.eng.abstr-s2-t7",
"type": "umlsterm",
"text": [
"papilloma virus"
],
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[
127,
142
]
],
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{
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}
]
},
{
"id": "DerHautarzt.60470927.eng.abstr-s2-t8",
"type": "umlsterm",
"text": [
"CD8 lymphocytes"
],
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[
196,
211
]
],
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{
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"db_id": "C0242629"
}
]
},
{
"id": "DerHautarzt.60470927.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"hyperplasia"
],
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[
268,
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]
],
"normalized": [
{
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"db_id": "C0020507"
}
]
},
{
"id": "DerHautarzt.60470927.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"focal epithelial hyperplasia"
],
"offsets": [
[
251,
279
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0206067"
}
]
}
] |
[] |
[] |
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"arg1_id": "DerHautarzt.60470927.eng.abstr-s2-t4",
"arg2_id": "DerHautarzt.60470927.eng.abstr-s2-t1",
"normalized": []
},
{
"id": "DerHautarzt.60470927.eng.abstr-s3-r1-t2.1-t1.1",
"type": "degree_of",
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"arg2_id": "DerHautarzt.60470927.eng.abstr-s3-t1",
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},
{
"id": "DerHautarzt.60470927.eng.abstr-s3-r2-t1.1-t2.1",
"type": "degree_of",
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"arg2_id": "DerHautarzt.60470927.eng.abstr-s3-t2",
"normalized": []
}
] |
DerHautarzt.60470930.eng.abstr
|
DerHautarzt.60470930.eng.abstr
|
[
{
"id": "DerHautarzt.60470930.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Amiodarone can occasionally lead to a slate-coloured pigmentation in chronically UV-exposed skin . A 63 year old patient presented with a pruritic bluish-purple pigmentation of the face 2 years after taking 400 mg amiodarone daily for 2 years . During the 24 months after the dose was reduced to 200 mg daily , the pigmentation remained unchanged . Amiodarone pigmentation is caused by the UV-induced accumulation of lipofuscin in dermal macrophages , depending on both the daily dose and the duration of therapy . In the differential diagnosis , pigmentation caused by other drugs is the main consideration . Cessation of therapy eventually leads to complete normalization of skin colour ."
],
"offsets": [
[
0,
690
]
]
}
] |
[
{
"id": "DerHautarzt.60470930.eng.abstr-s1-t1",
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"text": [
"Amiodarone"
],
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[
0,
10
]
],
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"db_name": "UMLS",
"db_id": "C0002598"
}
]
},
{
"id": "DerHautarzt.60470930.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"pigmentation"
],
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[
53,
65
]
],
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{
"db_name": "UMLS",
"db_id": "C0031911"
}
]
},
{
"id": "DerHautarzt.60470930.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"skin"
],
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[
92,
96
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.60470930.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"old"
],
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[
109,
112
]
],
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{
"db_name": "UMLS",
"db_id": "C0331059"
}
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},
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"id": "DerHautarzt.60470930.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"patient"
],
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[
113,
120
]
],
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{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.60470930.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"pigmentation"
],
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[
161,
173
]
],
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{
"db_name": "UMLS",
"db_id": "C0031911"
}
]
},
{
"id": "DerHautarzt.60470930.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"face"
],
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[
181,
185
]
],
"normalized": [
{
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"db_id": "C0015450"
}
]
},
{
"id": "DerHautarzt.60470930.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"amiodarone"
],
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[
214,
224
]
],
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"db_id": "C0002598"
}
]
},
{
"id": "DerHautarzt.60470930.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"pigmentation"
],
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[
315,
327
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0031911"
}
]
},
{
"id": "DerHautarzt.60470930.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"Amiodarone"
],
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[
349,
359
]
],
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"db_id": "C0002598"
}
]
},
{
"id": "DerHautarzt.60470930.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"pigmentation"
],
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[
360,
372
]
],
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{
"db_name": "UMLS",
"db_id": "C0031911"
}
]
},
{
"id": "DerHautarzt.60470930.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"lipofuscin"
],
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[
417,
427
]
],
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{
"db_name": "UMLS",
"db_id": "C0023789"
}
]
},
{
"id": "DerHautarzt.60470930.eng.abstr-s4-t4",
"type": "umlsterm",
"text": [
"macrophages"
],
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[
438,
449
]
],
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{
"db_name": "UMLS",
"db_id": "C0024432"
}
]
},
{
"id": "DerHautarzt.60470930.eng.abstr-s4-t5",
"type": "umlsterm",
"text": [
"therapy"
],
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[
505,
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]
],
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{
"db_name": "UMLS",
"db_id": "C0087111"
},
{
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}
]
},
{
"id": "DerHautarzt.60470930.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"diagnosis"
],
"offsets": [
[
535,
544
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011900"
},
{
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"db_id": "C0348026"
}
]
},
{
"id": "DerHautarzt.60470930.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"pigmentation"
],
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[
547,
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],
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}
]
},
{
"id": "DerHautarzt.60470930.eng.abstr-s5-t3",
"type": "umlsterm",
"text": [
"drugs"
],
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[
576,
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]
],
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{
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"db_id": "C0013227"
}
]
},
{
"id": "DerHautarzt.60470930.eng.abstr-s5-t4",
"type": "umlsterm",
"text": [
"differential diagnosis"
],
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[
522,
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],
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{
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"db_id": "C0220820"
},
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}
]
},
{
"id": "DerHautarzt.60470930.eng.abstr-s6-t1",
"type": "umlsterm",
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"therapy"
],
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[
623,
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}
]
},
{
"id": "DerHautarzt.60470930.eng.abstr-s6-t2",
"type": "umlsterm",
"text": [
"skin"
],
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[
677,
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]
],
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{
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}
]
},
{
"id": "DerHautarzt.60470930.eng.abstr-s6-t3",
"type": "umlsterm",
"text": [
"colour"
],
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[
682,
688
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0009393"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.60470930.eng.abstr-s1-r1-t2.1-t3.1",
"type": "degree_of",
"arg1_id": "DerHautarzt.60470930.eng.abstr-s6-t2",
"arg2_id": "DerHautarzt.60470930.eng.abstr-s6-t3",
"normalized": []
},
{
"id": "DerHautarzt.60470930.eng.abstr-s1-r2-t1.1-t3.1",
"type": "disrupts",
"arg1_id": "DerHautarzt.60470930.eng.abstr-s6-t1",
"arg2_id": "DerHautarzt.60470930.eng.abstr-s6-t3",
"normalized": []
},
{
"id": "DerHautarzt.60470930.eng.abstr-s1-r3-t3.1-t1.1",
"type": "produces",
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"arg2_id": "DerHautarzt.60470930.eng.abstr-s6-t1",
"normalized": []
},
{
"id": "DerHautarzt.60470930.eng.abstr-s1-r4-t3.1-t2.1",
"type": "degree_of",
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},
{
"id": "DerHautarzt.60470930.eng.abstr-s2-r1-t3.1-t1.1",
"type": "property_of",
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},
{
"id": "DerHautarzt.60470930.eng.abstr-s4-r1-t1.1-t4.1",
"type": "disrupts",
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"arg2_id": "DerHautarzt.60470930.eng.abstr-s5-t4",
"normalized": []
},
{
"id": "DerHautarzt.60470930.eng.abstr-s4-r2-t4.1-t3.1",
"type": "produces",
"arg1_id": "DerHautarzt.60470930.eng.abstr-s5-t4",
"arg2_id": "DerHautarzt.60470930.eng.abstr-s6-t3",
"normalized": []
},
{
"id": "DerHautarzt.60470930.eng.abstr-s4-r3-t3.1-t1.1",
"type": "interacts_with",
"arg1_id": "DerHautarzt.60470930.eng.abstr-s6-t3",
"arg2_id": "DerHautarzt.60470930.eng.abstr-s6-t1",
"normalized": []
},
{
"id": "DerHautarzt.60470930.eng.abstr-s4-r4-t3.1-t4.1",
"type": "disrupts",
"arg1_id": "DerHautarzt.60470930.eng.abstr-s6-t3",
"arg2_id": "DerHautarzt.60470930.eng.abstr-s5-t4",
"normalized": []
},
{
"id": "DerHautarzt.60470930.eng.abstr-s4-r5-t4.1-t1.1",
"type": "produces",
"arg1_id": "DerHautarzt.60470930.eng.abstr-s5-t4",
"arg2_id": "DerHautarzt.60470930.eng.abstr-s6-t1",
"normalized": []
},
{
"id": "DerHautarzt.60470930.eng.abstr-s4-r6-t4.1-t5.1",
"type": "location_of",
"arg1_id": "DerHautarzt.60470930.eng.abstr-s5-t4",
"arg2_id": "DerHautarzt.60470930.eng.abstr-s4-t5",
"normalized": []
},
{
"id": "DerHautarzt.60470930.eng.abstr-s4-r7-t5.1-t1.1",
"type": "uses",
"arg1_id": "DerHautarzt.60470930.eng.abstr-s4-t5",
"arg2_id": "DerHautarzt.60470930.eng.abstr-s6-t1",
"normalized": []
},
{
"id": "DerHautarzt.60470930.eng.abstr-s4-r8-t1.1-t3.1",
"type": "interacts_with",
"arg1_id": "DerHautarzt.60470930.eng.abstr-s6-t1",
"arg2_id": "DerHautarzt.60470930.eng.abstr-s6-t3",
"normalized": []
},
{
"id": "DerHautarzt.60470930.eng.abstr-s5-r1-t4.1-t1.2",
"type": "measures",
"arg1_id": "DerHautarzt.60470930.eng.abstr-s5-t4",
"arg2_id": "DerHautarzt.60470930.eng.abstr-s6-t1",
"normalized": []
},
{
"id": "DerHautarzt.60470930.eng.abstr-s5-r2-t1.1-t3.1",
"type": "analyzes",
"arg1_id": "DerHautarzt.60470930.eng.abstr-s6-t1",
"arg2_id": "DerHautarzt.60470930.eng.abstr-s6-t3",
"normalized": []
},
{
"id": "DerHautarzt.60470930.eng.abstr-s5-r4-t4.1-t3.1",
"type": "analyzes",
"arg1_id": "DerHautarzt.60470930.eng.abstr-s5-t4",
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},
{
"id": "DerHautarzt.60470930.eng.abstr-s6-r1-t1.1-t3.1",
"type": "result_of",
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"arg2_id": "DerHautarzt.60470930.eng.abstr-s6-t3",
"normalized": []
}
] |
DerHautarzt.70480002.eng.abstr
|
DerHautarzt.70480002.eng.abstr
|
[
{
"id": "DerHautarzt.70480002.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Oral treatment of scabies with ivermectin , which is not yet registered for this indication , appears to be an effective , inexpensive treatment with negligible side effects . We present the current clinical experience in the treatment of scabies with ivermectin as well as the available pharmacological data . For endemic scabies or unreliable or immuncompromised patients , ivermectin offers an effective systemic treatment of scabies ."
],
"offsets": [
[
0,
438
]
]
}
] |
[
{
"id": "DerHautarzt.70480002.eng.abstr-s1-t1",
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"text": [
"treatment"
],
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[
5,
14
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0087111"
},
{
"db_name": "UMLS",
"db_id": "C0039798"
}
]
},
{
"id": "DerHautarzt.70480002.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"scabies"
],
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[
18,
25
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0036262"
}
]
},
{
"id": "DerHautarzt.70480002.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"ivermectin"
],
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[
31,
41
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0022322"
}
]
},
{
"id": "DerHautarzt.70480002.eng.abstr-s1-t4",
"type": "umlsterm",
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"treatment"
],
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[
135,
144
]
],
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{
"db_name": "UMLS",
"db_id": "C0087111"
},
{
"db_name": "UMLS",
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]
},
{
"id": "DerHautarzt.70480002.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"side effects"
],
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[
161,
173
]
],
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{
"db_name": "UMLS",
"db_id": "C0001688"
}
]
},
{
"id": "DerHautarzt.70480002.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"treatment"
],
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[
226,
235
]
],
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{
"db_name": "UMLS",
"db_id": "C0087111"
},
{
"db_name": "UMLS",
"db_id": "C0039798"
}
]
},
{
"id": "DerHautarzt.70480002.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"scabies"
],
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[
239,
246
]
],
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{
"db_name": "UMLS",
"db_id": "C0036262"
}
]
},
{
"id": "DerHautarzt.70480002.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"ivermectin"
],
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[
252,
262
]
],
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{
"db_name": "UMLS",
"db_id": "C0022322"
}
]
},
{
"id": "DerHautarzt.70480002.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"endemic"
],
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[
315,
322
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0243130"
}
]
},
{
"id": "DerHautarzt.70480002.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"scabies"
],
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[
323,
330
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0036262"
}
]
},
{
"id": "DerHautarzt.70480002.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"patients"
],
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[
365,
373
]
],
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{
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}
]
},
{
"id": "DerHautarzt.70480002.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"ivermectin"
],
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[
376,
386
]
],
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{
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"db_id": "C0022322"
}
]
},
{
"id": "DerHautarzt.70480002.eng.abstr-s3-t5",
"type": "umlsterm",
"text": [
"treatment"
],
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[
416,
425
]
],
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"db_id": "C0087111"
},
{
"db_name": "UMLS",
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}
]
},
{
"id": "DerHautarzt.70480002.eng.abstr-s3-t6",
"type": "umlsterm",
"text": [
"scabies"
],
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[
429,
436
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0036262"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.70480002.eng.abstr-s1-r1-t3.1-t1.1",
"type": "affects",
"arg1_id": "DerHautarzt.70480002.eng.abstr-s3-t3",
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},
{
"id": "DerHautarzt.70480002.eng.abstr-s1-r2-t4.1-t1.1",
"type": "associated_with",
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},
{
"id": "DerHautarzt.70480002.eng.abstr-s1-r3-t4.1-t3.1",
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},
{
"id": "DerHautarzt.70480002.eng.abstr-s1-r5-t3.1-t1.1",
"type": "diagnoses",
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},
{
"id": "DerHautarzt.70480002.eng.abstr-s1-r6-t3.1-t5.1",
"type": "diagnoses",
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"arg2_id": "DerHautarzt.70480002.eng.abstr-s3-t5",
"normalized": []
},
{
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DerHautarzt.70480012.eng.abstr
|
DerHautarzt.70480012.eng.abstr
|
[
{
"id": "DerHautarzt.70480012.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Over 72000 prescriptions from practicing dermatologists were reviewed to obtain an overview of current prescribing trends including both medical and economic aspects . One main point of concern was the quality of compounded prescriptions , which play an important role in dermatology , comprising 39.5% of the total and 47.8% of the topical prescriptions . Mixtures containing corticosteroids play a central role , being present in 45.2% of topical preparations , and comprising 35.9% of the standard preparations . While most mixtures were totally acceptable , some seemed questionable , either because of the number of active ingredients ( as many as 7 ) , the combinations ( corticosteroid , antibiotics and antifungals ) or the selected concentrations . The increased number of prescriptions and the use of compounding both appear fertile areas for cost-control measures ."
],
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0,
876
]
]
}
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[] |
[] |
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"id": "DerHautarzt.70480012.eng.abstr-s4-r10-t2.1-t1.1",
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DerHautarzt.70480021.eng.abstr
|
DerHautarzt.70480021.eng.abstr
|
[
{
"id": "DerHautarzt.70480021.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Cutis marmorata telangiectatica congenita ( van Lohuizen ) is a rare skin disease in newborn or very young children . From the dermatological point of view , therapy is either not necessary or uncomplicated . However , the dermatologist and/or the pediatrician need to search for possibly associated anomalies . Clinical characteristics of 15 patients examined in the Fachklinik Hornheide within the last 11 years are presented . By giving a survey of the anomalies associated with cutis marmorata telangiectatica congenita , we demonstrate the need of neuropediatric , ophthalmologic and orthopedic examinations in addition the pedriatic and dermatologic examinations ."
],
"offsets": [
[
0,
670
]
]
}
] |
[
{
"id": "DerHautarzt.70480021.eng.abstr-s1-t1",
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"skin"
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69,
73
]
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}
]
},
{
"id": "DerHautarzt.70480021.eng.abstr-s1-t2",
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"disease"
],
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74,
81
]
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"db_id": "C0012634"
}
]
},
{
"id": "DerHautarzt.70480021.eng.abstr-s1-t3",
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"newborn"
],
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85,
92
]
],
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{
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"db_id": "C0021289"
}
]
},
{
"id": "DerHautarzt.70480021.eng.abstr-s1-t4",
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"children"
],
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107,
115
]
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}
]
},
{
"id": "DerHautarzt.70480021.eng.abstr-s1-t5",
"type": "umlsterm",
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"skin disease"
],
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69,
81
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"db_id": "C0037274"
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},
{
"id": "DerHautarzt.70480021.eng.abstr-s2-t1",
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"therapy"
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158,
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},
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"id": "DerHautarzt.70480021.eng.abstr-s3-t1",
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"need"
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261,
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},
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"id": "DerHautarzt.70480021.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"anomalies"
],
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300,
309
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],
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"db_id": "C0000769"
}
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},
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"id": "DerHautarzt.70480021.eng.abstr-s4-t1",
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"patients"
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343,
351
]
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"db_id": "C0030705"
}
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},
{
"id": "DerHautarzt.70480021.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"survey"
],
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442,
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},
{
"id": "DerHautarzt.70480021.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"anomalies"
],
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456,
465
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},
{
"id": "DerHautarzt.70480021.eng.abstr-s5-t3",
"type": "umlsterm",
"text": [
"need"
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545,
549
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],
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}
]
},
{
"id": "DerHautarzt.70480021.eng.abstr-s5-t4",
"type": "umlsterm",
"text": [
"orthopedic"
],
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589,
599
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0029355"
}
]
}
] |
[] |
[] |
[
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},
{
"id": "DerHautarzt.70480021.eng.abstr-s1-r3-t2.1-t1.1",
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{
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},
{
"id": "DerHautarzt.70480021.eng.abstr-s5-r2-t3.1-t1.1",
"type": "evaluation_of",
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},
{
"id": "DerHautarzt.70480021.eng.abstr-s5-r3-t2.1-t1.1",
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}
] |
DerHautarzt.70480026.eng.abstr
|
DerHautarzt.70480026.eng.abstr
|
[
{
"id": "DerHautarzt.70480026.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Purpose : To characterize human skin qualitatively and quantitatively using high-resolution magnetic resonance tomography ( MRT ) and to compare skin thickness measurements from MRT and histological specimens ."
],
"offsets": [
[
0,
210
]
]
}
] |
[
{
"id": "DerHautarzt.70480026.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"human"
],
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[
26,
31
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0020114"
}
]
},
{
"id": "DerHautarzt.70480026.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"skin"
],
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[
32,
36
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.70480026.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"magnetic"
],
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[
92,
100
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0024488"
}
]
},
{
"id": "DerHautarzt.70480026.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"resonance"
],
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[
101,
110
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0459800"
}
]
},
{
"id": "DerHautarzt.70480026.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"tomography"
],
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[
111,
121
]
],
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{
"db_name": "UMLS",
"db_id": "C0040395"
}
]
},
{
"id": "DerHautarzt.70480026.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"skin"
],
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[
145,
149
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.70480026.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"measurements"
],
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[
160,
172
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0242485"
}
]
},
{
"id": "DerHautarzt.70480026.eng.abstr-s1-t8",
"type": "umlsterm",
"text": [
"magnetic resonance"
],
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[
92,
110
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0917874"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.70480026.eng.abstr-s1-r1-t7.1-t3.1",
"type": "issue_in",
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},
{
"id": "DerHautarzt.70480026.eng.abstr-s1-r2-t5.1-t6.1",
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},
{
"id": "DerHautarzt.70480026.eng.abstr-s1-r3-t8.1-t3.1",
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},
{
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},
{
"id": "DerHautarzt.70480026.eng.abstr-s1-r6-t1.1-t3.1",
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},
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},
{
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},
{
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},
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},
{
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},
{
"id": "DerHautarzt.70480026.eng.abstr-s1-r12-t5.1-t8.1",
"type": "measures",
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},
{
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},
{
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},
{
"id": "DerHautarzt.70480026.eng.abstr-s1-r15-t6.1-t4.1",
"type": "result_of",
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},
{
"id": "DerHautarzt.70480026.eng.abstr-s1-r16-t4.1-t3.1",
"type": "issue_in",
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},
{
"id": "DerHautarzt.70480026.eng.abstr-s1-r17-t6.1-t8.1",
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},
{
"id": "DerHautarzt.70480026.eng.abstr-s1-r18-t7.1-t1.1",
"type": "measures",
"arg1_id": "DerHautarzt.70480026.eng.abstr-s1-t7",
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},
{
"id": "DerHautarzt.70480026.eng.abstr-s1-r19-t7.1-t8.1",
"type": "measures",
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},
{
"id": "DerHautarzt.70480026.eng.abstr-s1-r20-t6.1-t1.1",
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},
{
"id": "DerHautarzt.70480026.eng.abstr-s1-r21-t5.1-t7.1",
"type": "measures",
"arg1_id": "DerHautarzt.70480026.eng.abstr-s1-t5",
"arg2_id": "DerHautarzt.70480026.eng.abstr-s1-t7",
"normalized": []
},
{
"id": "DerHautarzt.70480026.eng.abstr-s1-r22-t7.1-t4.1",
"type": "measures",
"arg1_id": "DerHautarzt.70480026.eng.abstr-s1-t7",
"arg2_id": "DerHautarzt.70480026.eng.abstr-s1-t4",
"normalized": []
},
{
"id": "DerHautarzt.70480026.eng.abstr-s1-r23-t1.1-t8.1",
"type": "result_of",
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},
{
"id": "DerHautarzt.70480026.eng.abstr-s1-r24-t1.1-t4.1",
"type": "result_of",
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"normalized": []
},
{
"id": "DerHautarzt.70480026.eng.abstr-s1-r25-t6.1-t3.1",
"type": "issue_in",
"arg1_id": "DerHautarzt.70480026.eng.abstr-s1-t6",
"arg2_id": "DerHautarzt.70480026.eng.abstr-s1-t3",
"normalized": []
},
{
"id": "DerHautarzt.70480026.eng.abstr-s1-r26-t7.1-t3.1",
"type": "method_of",
"arg1_id": "DerHautarzt.70480026.eng.abstr-s1-t7",
"arg2_id": "DerHautarzt.70480026.eng.abstr-s1-t3",
"normalized": []
}
] |
DerHautarzt.70480031.eng.abstr
|
DerHautarzt.70480031.eng.abstr
|
[
{
"id": "DerHautarzt.70480031.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Macular amyloidosis ( MA ) and lichen amyloidosus ( LA ) are the two major variants of the primary cutaneous amyloidoses which present with severe and therapy resistent itching . Various therapeutic modalities such as antihistamines , intralesional injection or topical application of corticosteroids , etretinate , UVB irradiation and dermoabrasion have been employed with variable success . Recently , in a few case reports authors have observed encouraging beneficial clinical effects by using topical dimethyl sulphoxide ( DMSO ) . In our study 10 patients with either MA or LA or biphasic amyloidosis were treated with a 50% solution of DMSO in water . 9 of them showed marked clinical improvement at the end of 6-20 weeks of treatment . Degranulation and depletion of the mast cells by DMSO is the most probable explanation for the rapid improvement of itching beginning within the first week of therapy . Remarkable flattening of the lichenoid papules which was obtained within 11 weeks of treatment is interpreted as a result of the improvement of itching and the related scratch effect . Histological examination after treatment revealed no disappearance of amyloid deposits in the papillary dermis . In the follow-up period relapses of itching and papules were observed . Therefore further studies are needed to find out the optimal procedure of therapy ."
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] |
[] |
[] |
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] |
DerHautarzt.70480038.eng.abstr
|
DerHautarzt.70480038.eng.abstr
|
[
{
"id": "DerHautarzt.70480038.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Iris nodules in neurofibromatosis I have become an important tool in the differential diagnosis of phakomatoses . The clinical appearance and importance of these nodules first recognized by Karl Lisch in Munich in 1937. The diagnosis and differential diagnosis of Lisch nodules are illustrated . The importance of iris nodules in genetic counselling of patients and their relatives is discussed , with emphasis on monosymptomatic cases . Histologically Lisch nodules are formed by aggregations of oval to round cells that form dome-shaped papules on the anterior layer of the iris . Immunhistochemically these cells are characterized by positive staining with antibodies against vimentin and S-100 protein . This proves their ectodermal differentiation . Thus Lisch nodules can be seen as a direct manifestation of neuroectodermal disturbances in neurofibromatosis I."
],
"offsets": [
[
0,
867
]
]
}
] |
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],
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0,
4
]
],
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}
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},
{
"id": "DerHautarzt.70480038.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"neurofibromatosis"
],
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[
16,
33
]
],
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}
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},
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"type": "umlsterm",
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"diagnosis"
],
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[
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95
]
],
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}
]
},
{
"id": "DerHautarzt.70480038.eng.abstr-s1-t4",
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],
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{
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},
{
"id": "DerHautarzt.70480038.eng.abstr-s2-t3",
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},
{
"id": "DerHautarzt.70480038.eng.abstr-s3-t1",
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"iris"
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],
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},
{
"id": "DerHautarzt.70480038.eng.abstr-s3-t3",
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"id": "DerHautarzt.70480038.eng.abstr-s4-t1",
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{
"id": "DerHautarzt.70480038.eng.abstr-s4-t2",
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] |
[] |
[] |
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},
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},
{
"id": "DerHautarzt.70480038.eng.abstr-s5-r19-t5.1-t1.1",
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}
] |
DerHautarzt.70480042.eng.abstr
|
DerHautarzt.70480042.eng.abstr
|
[
{
"id": "DerHautarzt.70480042.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A ten year old boy with linear erythema above the right eyebrow and a groove in the underlying skull bone is described . Histological examination of a biopsy revealed a spotty , periadnexal , perivascular , lymphocytic infiltrate . The papillary dermis was almost absent and the collagen fibres were slightly thickened . Based on the clinical appearance and the histology a diagnosis of linear scleroderma ( en coup de sabre ) was made . As the signs and symptoms were progressive , treatment with D-penicillamine was started . Subsequently the erythema disappeared . The shallow groove in the skull bone remained palpable . After thirteen months , treatment was stopped . The patient is currently free of signs and symptoms after a follow-up period of three and a half years . We feel that the strong clinical improvement is due to treatment with D-penicillamine rather than to the natural course of the disease ."
],
"offsets": [
[
0,
914
]
]
}
] |
[
{
"id": "DerHautarzt.70480042.eng.abstr-s1-t1",
"type": "umlsterm",
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"old"
],
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[
11,
14
]
],
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{
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"db_id": "C0331059"
}
]
},
{
"id": "DerHautarzt.70480042.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"erythema"
],
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[
31,
39
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0041834"
}
]
},
{
"id": "DerHautarzt.70480042.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"right"
],
"offsets": [
[
50,
55
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0035621"
}
]
},
{
"id": "DerHautarzt.70480042.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"eyebrow"
],
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[
56,
63
]
],
"normalized": [
{
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"db_id": "C0015420"
}
]
},
{
"id": "DerHautarzt.70480042.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"skull"
],
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[
95,
100
]
],
"normalized": [
{
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"db_id": "C0037303"
}
]
},
{
"id": "DerHautarzt.70480042.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"bone"
],
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[
101,
105
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0262950"
}
]
},
{
"id": "DerHautarzt.70480042.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"biopsy"
],
"offsets": [
[
151,
157
]
],
"normalized": [
{
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"db_id": "C0220797"
},
{
"db_name": "UMLS",
"db_id": "C0005558"
}
]
},
{
"id": "DerHautarzt.70480042.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"dermis"
],
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[
246,
252
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011646"
}
]
},
{
"id": "DerHautarzt.70480042.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"collagen"
],
"offsets": [
[
279,
287
]
],
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DerHautarzt.70480045.eng.abstr
|
DerHautarzt.70480045.eng.abstr
|
[
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"id": "DerHautarzt.70480045.eng.abstr-passage-0",
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[] |
[] |
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DerHautarzt.70480051.eng.abstr
|
DerHautarzt.70480051.eng.abstr
|
[
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"We describe a patient with plexiform neurofibroma and contralateral circumscribed hyperpigmentation along the lines of Blaschko . Such findings represent a form of segmental neurofibromatosis . The origin and classification of segmental neurofibromatosis and its relationship to NFI ( von Recklinghausen disease ) are discussed ."
],
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[
0,
329
]
]
}
] |
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},
{
"id": "DerHautarzt.70480051.eng.abstr-s1-t2",
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"neurofibroma"
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37,
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{
"id": "DerHautarzt.70480051.eng.abstr-s1-t3",
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"hyperpigmentation"
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82,
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},
{
"id": "DerHautarzt.70480051.eng.abstr-s1-t5",
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"plexiform neurofibroma"
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27,
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"id": "DerHautarzt.70480051.eng.abstr-s2-t1",
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"form"
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"id": "DerHautarzt.70480051.eng.abstr-s2-t3",
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"neurofibromatosis"
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"origin"
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]
},
{
"id": "DerHautarzt.70480051.eng.abstr-s3-t3",
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"id": "DerHautarzt.70480051.eng.abstr-s3-t4",
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"id": "DerHautarzt.70480051.eng.abstr-s3-t5",
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{
"id": "DerHautarzt.70480051.eng.abstr-s3-t6",
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285,
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{
"db_name": "UMLS",
"db_id": "C0027831"
}
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}
] |
[] |
[] |
[
{
"id": "DerHautarzt.70480051.eng.abstr-s1-r1-t4.1-t3.1",
"type": "affects",
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{
"id": "DerHautarzt.70480051.eng.abstr-s1-r3-t2.1-t3.1",
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},
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},
{
"id": "DerHautarzt.70480051.eng.abstr-s1-r7-t4.1-t2.1",
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},
{
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},
{
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},
{
"id": "DerHautarzt.70480051.eng.abstr-s1-r10-t3.1-t2.1",
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},
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},
{
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"id": "DerHautarzt.70480051.eng.abstr-s3-r3-t4.1-t2.2",
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{
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},
{
"id": "DerHautarzt.70480051.eng.abstr-s3-r5-t2.2-t4.1",
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"id": "DerHautarzt.70480051.eng.abstr-s3-r6-t6.1-t4.1",
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}
] |
DerHautarzt.70480094.eng.abstr
|
DerHautarzt.70480094.eng.abstr
|
[
{
"id": "DerHautarzt.70480094.eng.abstr-passage-0",
"type": "abstract",
"text": [
"High-dose UVA1 therapy is an effective treatment of patients with acute atopic dermatitis . However , some patients do not respond well to this new therapy . We attempted to further characterize the non-responder population in a retrospective study . Two closely matched groups of responders ( n=20) and non-responders ( n=20) were compared . No significant differences were observed between both groups with respect to the following parameters : skin type , minimal erythema dose , single and cumulative doses of UVA1, and peripheral blood eosinophils . However , non-responders were characterized by a highly elevated atopic score , and by high levels of total IgE and of specific IgE . Furthermore , colonization of the skin with Staphylococcus aureus occured at higher densities , and intestinal growth of Candida albicans was more frequently observed . These data indicate that high-dose UVA1 irradiation is not effective in all patients suffering from atopic dermatitis . We conclude that non-responders with complicating infections might benefit from the combination of high-dose UVA1 therapy and antibiotic or antimycotic treatment ."
],
"offsets": [
[
0,
1141
]
]
}
] |
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},
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"id": "DerHautarzt.70480094.eng.abstr-s1-t2",
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},
{
"id": "DerHautarzt.70480094.eng.abstr-s1-t3",
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"id": "DerHautarzt.70480094.eng.abstr-s1-t4",
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"id": "DerHautarzt.70480094.eng.abstr-s1-t5",
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"id": "DerHautarzt.70480094.eng.abstr-s3-t1",
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"population"
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213,
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},
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"id": "DerHautarzt.70480094.eng.abstr-s3-t2",
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"retrospective"
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229,
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"id": "DerHautarzt.70480094.eng.abstr-s3-t3",
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},
{
"id": "DerHautarzt.70480094.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"erythema"
],
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{
"id": "DerHautarzt.70480094.eng.abstr-s5-t3",
"type": "umlsterm",
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"single"
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},
{
"id": "DerHautarzt.70480094.eng.abstr-s5-t4",
"type": "umlsterm",
"text": [
"blood"
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]
},
{
"id": "DerHautarzt.70480094.eng.abstr-s5-t5",
"type": "umlsterm",
"text": [
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],
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541,
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},
{
"id": "DerHautarzt.70480094.eng.abstr-s5-t6",
"type": "umlsterm",
"text": [
"blood eosinophils"
],
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535,
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],
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},
{
"id": "DerHautarzt.70480094.eng.abstr-s6-t1",
"type": "umlsterm",
"text": [
"IgE"
],
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663,
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]
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{
"id": "DerHautarzt.70480094.eng.abstr-s6-t2",
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"IgE"
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},
{
"id": "DerHautarzt.70480094.eng.abstr-s7-t1",
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"skin"
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723,
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},
{
"id": "DerHautarzt.70480094.eng.abstr-s7-t2",
"type": "umlsterm",
"text": [
"Staphylococcus"
],
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733,
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],
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},
{
"id": "DerHautarzt.70480094.eng.abstr-s7-t3",
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"text": [
"growth"
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},
{
"id": "DerHautarzt.70480094.eng.abstr-s7-t4",
"type": "umlsterm",
"text": [
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],
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{
"id": "DerHautarzt.70480094.eng.abstr-s7-t5",
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{
"id": "DerHautarzt.70480094.eng.abstr-s7-t6",
"type": "umlsterm",
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]
},
{
"id": "DerHautarzt.70480094.eng.abstr-s8-t1",
"type": "umlsterm",
"text": [
"irradiation"
],
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],
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"db_id": "C0851346"
}
]
},
{
"id": "DerHautarzt.70480094.eng.abstr-s8-t2",
"type": "umlsterm",
"text": [
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]
},
{
"id": "DerHautarzt.70480094.eng.abstr-s8-t3",
"type": "umlsterm",
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]
},
{
"id": "DerHautarzt.70480094.eng.abstr-s8-t4",
"type": "umlsterm",
"text": [
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],
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}
]
},
{
"id": "DerHautarzt.70480094.eng.abstr-s9-t1",
"type": "umlsterm",
"text": [
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DerHautarzt.70480100.eng.abstr
|
DerHautarzt.70480100.eng.abstr
|
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{
"id": "DerHautarzt.70480100.eng.abstr-passage-0",
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"text": [
"Guidelines of good clinical practice regulate controlled clinical studies . Goal of the study , type of treatment and possible side effects have to be explained . The physician faces problems , if the study includes a \" no treatment group \" . Referring to the literature and based on our own experience with tumor patients , several criteria are proposed to optimize the recruitment of patients . Important points are :"
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] |
[] |
[] |
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DerHautarzt.70480103.eng.abstr
|
DerHautarzt.70480103.eng.abstr
|
[
{
"id": "DerHautarzt.70480103.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Mollusca contagiosa predominantly affect children ; their occurrence in adults is rare . In recent years many descriptions of mollusca contagiosa in immunosuppressed patients , mostly in HIV-infected individuals , have appeared . We analysed the occurrence of mollusca contagiosa in a large group of HIV-patients and examined their relation to the immune status and their prognostic significance ."
],
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[
0,
397
]
]
}
] |
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}
] |
[] |
[] |
[
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}
] |
DerHautarzt.70480110.eng.abstr
|
DerHautarzt.70480110.eng.abstr
|
[
{
"id": "DerHautarzt.70480110.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The healing of wounds by secondary intention is a simple method to close operative defects . The quality of wound healing will depend on the anatomic site on the face as well as on size and depth of the defect . Best functional and cosmetic results are obtained at locations with concave geometry and when the defect lies symmetrically at the interface of two anatomic subunits . Partial reconstruction or guiding sutures can create a symmetric defect in relation to anatomic subunits which will heal by second intention . This simple and efficient operative procedure is ilustrated by two case reports ."
],
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[
0,
604
]
]
}
] |
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{
"id": "DerHautarzt.70480110.eng.abstr-s1-t2",
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"face"
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"id": "DerHautarzt.70480110.eng.abstr-s2-t4",
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"defect"
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"id": "DerHautarzt.70480110.eng.abstr-s2-t5",
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"sutures"
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}
] |
[] |
[] |
[
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"type": "result_of",
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},
{
"id": "DerHautarzt.70480110.eng.abstr-s1-r2-t2.2-t3.1",
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},
{
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},
{
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},
{
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"type": "associated_with",
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},
{
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},
{
"id": "DerHautarzt.70480110.eng.abstr-s1-r9-t3.1-t1.2",
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},
{
"id": "DerHautarzt.70480110.eng.abstr-s1-r10-t2.2-t1.1",
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},
{
"id": "DerHautarzt.70480110.eng.abstr-s1-r11-t5.1-t2.2",
"type": "result_of",
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},
{
"id": "DerHautarzt.70480110.eng.abstr-s1-r12-t5.1-t3.1",
"type": "result_of",
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},
{
"id": "DerHautarzt.70480110.eng.abstr-s1-r13-t1.1-t2.2",
"type": "associated_with",
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"arg2_id": "DerHautarzt.70480110.eng.abstr-s5-t2",
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},
{
"id": "DerHautarzt.70480110.eng.abstr-s1-r14-t2.2-t1.1",
"type": "result_of",
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},
{
"id": "DerHautarzt.70480110.eng.abstr-s1-r15-t3.1-t1.1",
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},
{
"id": "DerHautarzt.70480110.eng.abstr-s2-r1-t4.1-t1.1",
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},
{
"id": "DerHautarzt.70480110.eng.abstr-s2-r2-t1.1-t4.1",
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},
{
"id": "DerHautarzt.70480110.eng.abstr-s2-r4-t4.1-t1.2",
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},
{
"id": "DerHautarzt.70480110.eng.abstr-s4-r1-t2.1-t4.1",
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},
{
"id": "DerHautarzt.70480110.eng.abstr-s4-r2-t3.1-t4.1",
"type": "result_of",
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"arg2_id": "DerHautarzt.70480110.eng.abstr-s4-t4",
"normalized": []
}
] |
DerHautarzt.70480113.eng.abstr
|
DerHautarzt.70480113.eng.abstr
|
[
{
"id": "DerHautarzt.70480113.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Erythema elevatum diutinum ( EED ) is a rare disease presenting with persistent red to yellow-brown papules or plaques which are mainly localized symmetrically on the extensor aspects of the hands and fingers , the elbows and the knees . The histology shows a leucocytoclastic vasculitis in early lesions and fibrosis of the dermis later on . Dapsone is the treatment of choice . Today , EED is usually assigned to the neutrophilic dermatoses in which an association with hematological disturbances is well documented . We report on a patient with EED and glioma WHO grade IV , a coincidence unreported hitherto . Additionally , we review the literature on diseases associated with EED ."
],
"offsets": [
[
0,
687
]
]
}
] |
[
{
"id": "DerHautarzt.70480113.eng.abstr-s1-t1",
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"Erythema"
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0,
8
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],
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},
{
"id": "DerHautarzt.70480113.eng.abstr-s1-t2",
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"disease"
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]
},
{
"id": "DerHautarzt.70480113.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"plaques"
],
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111,
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]
],
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"db_id": "C0011389"
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}
]
},
{
"id": "DerHautarzt.70480113.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"hands"
],
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191,
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]
],
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"db_id": "C0018563"
}
]
},
{
"id": "DerHautarzt.70480113.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"fingers"
],
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[
201,
208
]
],
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"db_id": "C0016129"
}
]
},
{
"id": "DerHautarzt.70480113.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"elbows"
],
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215,
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]
],
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"db_id": "C0013769"
}
]
},
{
"id": "DerHautarzt.70480113.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"knees"
],
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230,
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]
],
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"db_id": "C0022742"
}
]
},
{
"id": "DerHautarzt.70480113.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"histology"
],
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242,
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],
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}
]
},
{
"id": "DerHautarzt.70480113.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"vasculitis"
],
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277,
287
]
],
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}
]
},
{
"id": "DerHautarzt.70480113.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"fibrosis"
],
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309,
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]
],
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"db_id": "C0016059"
}
]
},
{
"id": "DerHautarzt.70480113.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"dermis"
],
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"db_id": "C0011646"
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]
},
{
"id": "DerHautarzt.70480113.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"leucocytoclastic vasculitis"
],
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260,
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]
],
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"db_id": "C0151436"
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]
},
{
"id": "DerHautarzt.70480113.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"Dapsone"
],
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],
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}
]
},
{
"id": "DerHautarzt.70480113.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"treatment"
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]
},
{
"id": "DerHautarzt.70480113.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"choice"
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]
},
{
"id": "DerHautarzt.70480113.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"dermatoses"
],
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432,
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],
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"db_id": "C0037274"
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]
},
{
"id": "DerHautarzt.70480113.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"association"
],
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],
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DerHautarzt.70480118.eng.abstr
|
DerHautarzt.70480118.eng.abstr
|
[
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"The ubiquitous Mycobacterium avium-intracellulare ( MAI ) is the most frequent cause of disseminated atypical mycobacteriosis in AIDS patients . MAI infections may develop in patients with other acquired immune defects , such as connective tissue disorders . In adults , the gastrointestinal and respiratory systems are most frequently affected . We report a patient with dermatomyositis receiving immunosuppressive therapy in whom only the skin and the skeletal system were affected by MAI . Because it presented with polymyositis-like symptoms , the infection was initially not identified and treated . The MAI was cultured from a periarticular joint effusion from the right upper arm and from venous blood , as well as identified histologically in lesional skin . Resistance to antibiotics developed most likely because the patient failed to take oral antibiotics regularly . Because of an acute exacerbation of the tumor-associated dermatomyositis , immunosuppressive therapy was initiated , while the tuberculostatic therapy was continued . Using these therapies both diseases markedly improved . In patients with connective tissue disorders receiving longterm immunosuppressive therapy , especially when changes in symptoms and signs are observed , opportunistic infections such as MAI should be considered and included in the differential diagnosis ."
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] |
[] |
[] |
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] |
DerHautarzt.70480122.eng.abstr
|
DerHautarzt.70480122.eng.abstr
|
[
{
"id": "DerHautarzt.70480122.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Superior vena cava syndrome ( VCSS ) develops because of a progressive reduction of venous return from the head , neck and the upper extremities . The presenting sign of this relatively rare condition is often a rapidly developing , often massive facial edema . As a consequence , such the patients are often seen initially by a dermatologist . Other clinical characteristics may include cyanotic facial erythema , dilatation of the neck veins , and a prominent venous pattern n the anterior chest . Today , primary lung cancers and other mediastinal tumours represent the most common cause of VCSS , which may take a slowly progressive or a more fulminant course . In these cases , the disease develops rapidly and becomes life-threatening , requiring intensive medial diagnosis and care . We describe three patients with superior vena cava syndrome due to a ) bronchogenic carcinoma , b ) bihilar sarcoidosis and c ) metastasizing malignant melanoma . Since recognition of VCSS broadens the diagnostic spectrum of the dermatologist , an overview on its diagnostic and therapeutic implications is given based on our cases and the literature ."
],
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[
0,
1143
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]
}
] |
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[] |
[] |
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DerHautarzt.70480127.eng.abstr
|
DerHautarzt.70480127.eng.abstr
|
[
{
"id": "DerHautarzt.70480127.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report a case of bullous mastocytosis in a 30-month-old girl , who developed disseminated pruritic urticarial and bullous lesions on the trunk accompanied by episodes of vomiting and generalized flushing . Her problems began at the age of 6 months . Her stool was repeatedly positive for occult blood . Histamine and 5-hydroxytryptamine were measured in the urine and serum ; urine 5-hydroxytryptamine levels were elevated . In addition , trypsin and chymotrypsin levels were raised in the blister fluid . Metachromatic staining of the mast cells in a skin biopsy specimen confirmed the diagnosis . A combination of oral disodium cromoglycate and ketotifen produced a dramatic improvement of the cutaneous and gastrointestinal features ."
],
"offsets": [
[
0,
740
]
]
}
] |
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{
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],
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40
]
],
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],
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],
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{
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],
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],
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},
{
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"id": "DerHautarzt.70480127.eng.abstr-s3-t1",
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DerHautarzt.70480130.eng.abstr
|
DerHautarzt.70480130.eng.abstr
|
[
{
"id": "DerHautarzt.70480130.eng.abstr-passage-0",
"type": "abstract",
"text": [
"An isomorphic response is defined as a nonspecific skin stimulus eliciting a disease-specific skin reaction . We report on the development of the Koebner phenomenon in a 32 year old patient with psoriasis after skin testing with UVB at a dose above 0,055 J/cm2. In addition we describe a 28 years old patient who developed new psoriatic plaques in the areas affected by the virus after a varicella infection ."
],
"offsets": [
[
0,
409
]
]
}
] |
[
{
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"skin"
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55
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{
"id": "DerHautarzt.70480130.eng.abstr-s1-t2",
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"skin"
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"development"
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{
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"id": "DerHautarzt.70480130.eng.abstr-s2-t4",
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"id": "DerHautarzt.70480130.eng.abstr-s2-t6",
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{
"id": "DerHautarzt.70480130.eng.abstr-s2-t7",
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"old"
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{
"id": "DerHautarzt.70480130.eng.abstr-s2-t8",
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{
"id": "DerHautarzt.70480130.eng.abstr-s2-t9",
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{
"id": "DerHautarzt.70480130.eng.abstr-s2-t10",
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{
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{
"id": "DerHautarzt.70480130.eng.abstr-s2-t14",
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{
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}
] |
[] |
[] |
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] |
DerHautarzt.70480166.eng.abstr
|
DerHautarzt.70480166.eng.abstr
|
[
{
"id": "DerHautarzt.70480166.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Regular examinations of prostitutes may reduce the incidence of sexually transmitted diseases in this high risk group . Therefore since April 1988 regular mandatory examinations have been offered by the regional health office in cooperation with the Department of Dermatology of the Ruhr-University of Bochum . The aim of this study was to evaluate the acceptance and efficiency of such an examination . The study was based on anonymous questionnaires . Mean age of the 80 prostitutes was 31.4 ; 67 of then were born in Germany . 78 of the women always used condoms , while 71 thought that condoms prevent STDs . Three women suffered from a STD in the last 12 months . The majority the women ( 75 from this 80 prostitutes ) did not perceive the examination as discrimination , while 71 felt the examinations were of high quality . These results indicate that regular mandatory examinations should be part of health prevention care of prostitutes and that they are well accepted and tolerated by these women ."
],
"offsets": [
[
0,
1008
]
]
}
] |
[
{
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},
{
"id": "DerHautarzt.70480166.eng.abstr-s1-t2",
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"text": [
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{
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"id": "DerHautarzt.70480166.eng.abstr-s1-t4",
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"sexually transmitted diseases"
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"id": "DerHautarzt.70480166.eng.abstr-s5-t1",
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{
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},
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"id": "DerHautarzt.70480166.eng.abstr-s6-t2",
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"text": [
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{
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"id": "DerHautarzt.70480166.eng.abstr-s7-t1",
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{
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] |
[] |
[] |
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DerHautarzt.70480171.eng.abstr
|
DerHautarzt.70480171.eng.abstr
|
[
{
"id": "DerHautarzt.70480171.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We treated 8123 patients with invasive malignant melanoma were treated up to 1995. 2200 had invasive melanomas with less than 0.75 mm Breslow thickness ; of these , 45 developed metastases . Three had second primary tumors with greater thickness . One case showed metastasis from another tumor . In two cases the metastases were not ascertained histologically . The remaining 39 cases showed some peculiarities : a greater proportion of late and of internal ( as contrasted to regional ) metastases . Most of these primary tumors had a Breslow thickness of more than 0.5 mm and were Clark level III or even IV . Male patients and primary tumor sites in the area of head and neck were significantly over-represented ."
],
"offsets": [
[
0,
716
]
]
}
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"melanomas"
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101,
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178,
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] |
[] |
[] |
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] |
DerHautarzt.70480175.eng.abstr
|
DerHautarzt.70480175.eng.abstr
|
[
{
"id": "DerHautarzt.70480175.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A polymerase chain reaction ( PCR ) assay for the detection of dermatophytes was established . The primers \" TR1\" and \" TR2\" amplify a 581 bp fragment within the gene coding for the small ribosomal subunit ( 18S rRNA ) of fungi . PCR allowed the detection of isolates of 7 common dermatophytes and in addition several yeasts and moulds . Hybridisation with specific oligonucleotides results in the identification of dermatophytes and Candida albicans . Restriction analysis of the PCR product allowed us to distinguish between dermatophytes and yeasts or moulds . The specifity of the PCR with respect to fungi was assessed by testing human DNA collected from 42 dermis and epidermis specimens as well as DNA from selected plants and animals . To evaluate the clinical relevance of the PCR assay , 69 routinely collected skin and nail specimens were examined by PCR and culture . PCR detected dermatophytes in 35 and culture in 28 of 38 specimens that were classified as positive . Sensitivity of PCR ( 92% ) was higher than that of culture ( 73% ) . These results show that PCR has advantages over culture for the detection of dermatophytes ."
],
"offsets": [
[
0,
1143
]
]
}
] |
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"id": "DerHautarzt.70480175.eng.abstr-s1-t2",
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"assay"
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{
"id": "DerHautarzt.70480175.eng.abstr-s1-t3",
"type": "umlsterm",
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"dermatophytes"
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63,
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"id": "DerHautarzt.70480175.eng.abstr-s1-t4",
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2,
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}
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{
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"gene"
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"db_id": "C0017337"
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"id": "DerHautarzt.70480175.eng.abstr-s2-t2",
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"rRNA"
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"id": "DerHautarzt.70480175.eng.abstr-s2-t3",
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"fungi"
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"db_id": "C0521033"
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}
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},
{
"id": "DerHautarzt.70480175.eng.abstr-s3-t2",
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{
"id": "DerHautarzt.70480175.eng.abstr-s3-t3",
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{
"id": "DerHautarzt.70480175.eng.abstr-s4-t4",
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"id": "DerHautarzt.70480175.eng.abstr-s4-t5",
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{
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DerHautarzt.70480181.eng.abstr
|
DerHautarzt.70480181.eng.abstr
|
[
{
"id": "DerHautarzt.70480181.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We studied the clinical and histopathologic features in five patients with reticulated lentigo . This peculiar pigmented skin lesion has previously been described under the designations \" acquired reticulated lentigo \" , \" ink spot lentigo \" , \" reticulated black solar lentigo \" , \" reticulated ephelid \" , \" reticulated melanotic macule \" or \" reticulated lentigo \" . Each of the 4 males and 1 females in our study ( age range : 16 to 57 years ; mean age : 34 years ) had a single , 4-6 mm large , black macule with irregular , fingerlike extensions at the periphery . All lesions were situated on the upper back and surrounded by numerous sun-induced freckles . Dermatoscopic examination revealed irregularly formed \" meshes \" and confirmed the reticulated pattern seen clinically . Reticulated lentigo presented mostly in individuals with skin type 1 , red to blond hair , and blue eyes . The clinical diagnosis in 4 out of 5 cases was melanoma in situ . Histopathologically , reticulated lentigo was mainly characterized by a sharply circumscribed hyperpigmentation of the lower epidermis with accentuation at the tips of elongated and clubbed rete ridges . In addition , a normal or slightly increased melanocyte number in the basal layer and an infiltrate of melanophages in the upper dermis was noted . Reticulated lentigo shows histopathologic features similar to those of melanotic macules on volar skin and mucous membranes . Because of its characteristic clinical , dermatoscopic and histopathologic features reticulated lentigo can be regarded as a distinctive clinicopathologic entity ."
],
"offsets": [
[
0,
1600
]
]
}
] |
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] |
[] |
[] |
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] |
DerHautarzt.70480186.eng.abstr
|
DerHautarzt.70480186.eng.abstr
|
[
{
"id": "DerHautarzt.70480186.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report three new cases of the SAPHO syndrome . This acronyme consists of synovitis , acne , pustulosis , hyperostosis and osteitis . Symptoms of this syndrome , which may not all be present , are pustulotic skin diseases ( pustulosis palmoplantaris or severe acne ) associated with osteoarticular lesions ( mainly sternoclavicular hyperostosis , spondylarthropathies or chronic recurrent multifocal osteomyelitis ) . The dermatological aspects of this syndrome are discussed in detail ."
],
"offsets": [
[
0,
489
]
]
}
] |
[
{
"id": "DerHautarzt.70480186.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"syndrome"
],
"offsets": [
[
39,
47
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0039082"
}
]
},
{
"id": "DerHautarzt.70480186.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"SAPHO syndrome"
],
"offsets": [
[
33,
47
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0263859"
}
]
},
{
"id": "DerHautarzt.70480186.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"synovitis"
],
"offsets": [
[
76,
85
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0039103"
}
]
},
{
"id": "DerHautarzt.70480186.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"acne"
],
"offsets": [
[
88,
92
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0001144"
}
]
},
{
"id": "DerHautarzt.70480186.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"hyperostosis"
],
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[
108,
120
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0020492"
}
]
},
{
"id": "DerHautarzt.70480186.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"osteitis"
],
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[
125,
133
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0029400"
}
]
},
{
"id": "DerHautarzt.70480186.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"Symptoms"
],
"offsets": [
[
136,
144
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0683368"
}
]
},
{
"id": "DerHautarzt.70480186.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"syndrome"
],
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[
153,
161
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0039082"
}
]
},
{
"id": "DerHautarzt.70480186.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"skin"
],
"offsets": [
[
210,
214
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.70480186.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"diseases"
],
"offsets": [
[
215,
223
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0012634"
}
]
},
{
"id": "DerHautarzt.70480186.eng.abstr-s3-t5",
"type": "umlsterm",
"text": [
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DerHautarzt.70480191.eng.abstr
|
DerHautarzt.70480191.eng.abstr
|
[
{
"id": "DerHautarzt.70480191.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Angioid streaks were diagnosed in a 42-year-old woman . Since age 20 she had developed circumscribed atrophic yellow-grey lesions on her neck , axillae and other flexural sites . In spite of highly characteristic skin changes , the diagnosis of pseudoxanthoma elasticum was first confirmed by a biopsy from lesional skin 22 years after the disease onset . Based on the present case and an analysis of the recent literature , the findings characteristic for pseudoxanthoma elasticum in the skin , eyes and cardiovascular system are delineated , the differential diagnosis of the skin lesions , as well as the pathogenesis and the prognosis are discussed , and the new classification of pseudoxanthoma elasticum , based on major and minor criteria , is described ."
],
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0,
762
]
]
}
] |
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[] |
[] |
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] |
DerHautarzt.70480195.eng.abstr
|
DerHautarzt.70480195.eng.abstr
|
[
{
"id": "DerHautarzt.70480195.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Epinephrine ( adrenaline ) is an important drug in the treatment of severe anaphylactic reactions . Along with other drugs such as H1-antihistamines and glucocorticosteroids , it is found in every first aid kit for at-risk individuals , such as those who are allergic to insect stings . Subcutaneous or intramuscular injections if carried out by an untrained individual or the patient himself might give rise to potential problems . Therefore , it is common to prescribe epinephrine pressure aerosol as a safer alternative . If epinephrine aerosol is overused , it can cause serious problems . A patient developed by self-medication following a wasp sting lung edema as well as an erosive gastroduodenitis . She consumed two aerosol vials each of which contained about 73 mg of adrenaline ."
],
"offsets": [
[
0,
790
]
]
}
] |
[
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],
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0,
11
]
],
"normalized": [
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"db_id": "C0014563"
}
]
},
{
"id": "DerHautarzt.70480195.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"adrenaline"
],
"offsets": [
[
14,
24
]
],
"normalized": [
{
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] |
DerHautarzt.70480199.eng.abstr
|
DerHautarzt.70480199.eng.abstr
|
[
{
"id": "DerHautarzt.70480199.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Ergotamine-containing drugs are widely used in the treatment of acute migraine attacks . Among others , spastic vasoconstrictions are one of the possible side effects usually affecting the lower extremities and sometimes leading to gangrene . The case of a 75 year old woman is presented who was suffering from migraine-attacks since adolescence . Due to longterm use of ergotamine containing suppositories she developed perianal ulcers . After withdrawl of the drug the ulcers healed up entirely . The spectrum of ergotamine-induced side-effects and possible intervention strategies are discussed ."
],
"offsets": [
[
0,
599
]
]
}
] |
[
{
"id": "DerHautarzt.70480199.eng.abstr-s1-t1",
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"text": [
"drugs"
],
"offsets": [
[
22,
27
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0013227"
}
]
},
{
"id": "DerHautarzt.70480199.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"treatment"
],
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[
51,
60
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0087111"
},
{
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"db_id": "C0039798"
}
]
},
{
"id": "DerHautarzt.70480199.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"migraine"
],
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[
70,
78
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0149931"
}
]
},
{
"id": "DerHautarzt.70480199.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"spastic"
],
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[
104,
111
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0026838"
}
]
},
{
"id": "DerHautarzt.70480199.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"vasoconstrictions"
],
"offsets": [
[
112,
129
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0042396"
}
]
},
{
"id": "DerHautarzt.70480199.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"extremities"
],
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[
195,
206
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0015385"
}
]
},
{
"id": "DerHautarzt.70480199.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"side effects"
],
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[
154,
166
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0001688"
}
]
},
{
"id": "DerHautarzt.70480199.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"lower extremities"
],
"offsets": [
[
189,
206
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0023216"
}
]
},
{
"id": "DerHautarzt.70480199.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"old"
],
"offsets": [
[
265,
268
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0331059"
}
]
},
{
"id": "DerHautarzt.70480199.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"woman"
],
"offsets": [
[
269,
274
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0043210"
}
]
},
{
"id": "DerHautarzt.70480199.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"adolescence"
],
"offsets": [
[
334,
345
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0001578"
}
]
},
{
"id": "DerHautarzt.70480199.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"use"
],
"offsets": [
[
364,
367
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0042153"
}
]
},
{
"id": "DerHautarzt.70480199.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"ergotamine"
],
"offsets": [
[
371,
381
]
],
"normalized": [
{
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}
]
},
{
"id": "DerHautarzt.70480199.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"ergotamine"
],
"offsets": [
[
371,
381
]
],
"normalized": [
{
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"db_id": "C0002508"
}
]
},
{
"id": "DerHautarzt.70480199.eng.abstr-s4-t4",
"type": "umlsterm",
"text": [
"suppositories"
],
"offsets": [
[
393,
406
]
],
"normalized": [
{
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"db_id": "C0038854"
}
]
},
{
"id": "DerHautarzt.70480199.eng.abstr-s4-t5",
"type": "umlsterm",
"text": [
"ulcers"
],
"offsets": [
[
430,
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]
],
"normalized": [
{
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"db_id": "C0041582"
}
]
},
{
"id": "DerHautarzt.70480199.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"drug"
],
"offsets": [
[
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]
],
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}
]
},
{
"id": "DerHautarzt.70480199.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"ulcers"
],
"offsets": [
[
471,
477
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0041582"
}
]
}
] |
[] |
[] |
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DerHautarzt.70480228.eng.abstr
|
DerHautarzt.70480228.eng.abstr
|
[
{
"id": "DerHautarzt.70480228.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Most of the clinical , histological and immunohistological features of fogo selvagem resemble those of idiopathic pemphigus foliaceus ( PF ) . Both diseases are clinically characterized by small flaccid bullae evolving into to scaly and crusted lesions , sometimes with pustules , mainly in seborrhoic areas of the skin . Mucosal surfaces are mostly spared . The main histologic feature of endemic pemphigus foliaceus is a subcorneal acantholytic blister . Standard immunofluorescence studies demonstrate intercellular IgG deposits throughout the entire epidermis . These IgG antibodies are mainly of the IgG4-subclass. Almost all patients have circulating IgG-autoantibodies in their serum directed against stratified epithelial desmosomes . The fogo selvagem autoantibodies and the PF antibodies are directed against the 160 kD desmosomal glycoprotein desmoglein 1 which together with plakoglobin ( 85 kD ) forms a complex of adhesion proteins with desmosomes of stratified epithelia ."
],
"offsets": [
[
0,
987
]
]
}
] |
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],
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],
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},
{
"id": "DerHautarzt.70480228.eng.abstr-s6-t2",
"type": "umlsterm",
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],
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},
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]
},
{
"id": "DerHautarzt.70480228.eng.abstr-s6-t4",
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"desmosomes"
],
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[
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],
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},
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"id": "DerHautarzt.70480228.eng.abstr-s7-t1",
"type": "umlsterm",
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"id": "DerHautarzt.70480228.eng.abstr-s7-t4",
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] |
[] |
[] |
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] |
DerHautarzt.70480240.eng.abstr
|
DerHautarzt.70480240.eng.abstr
|
[
{
"id": "DerHautarzt.70480240.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In order to study the dermal uptake , time course , and urinary excretion of polycyclic aromatic hydrocarbons , the concentration of 1-hydroxypyrene in urine was determined by means of high performance liquid chromatography with fluorescence detection before , during , and after the topical treatment with coal tar in 19 patients suffering from prurigo simplex subacuta , microbial eczema , atopic dermatitis , eczematization after scabies , exanthematous lichen ruber , pityriasis lichenoides and cutaneous sarcoidosis ."
],
"offsets": [
[
0,
522
]
]
}
] |
[
{
"id": "DerHautarzt.70480240.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"time"
],
"offsets": [
[
38,
42
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0040223"
}
]
},
{
"id": "DerHautarzt.70480240.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"hydrocarbons"
],
"offsets": [
[
97,
109
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0020242"
}
]
},
{
"id": "DerHautarzt.70480240.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"concentration"
],
"offsets": [
[
116,
129
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0086045"
}
]
},
{
"id": "DerHautarzt.70480240.eng.abstr-s1-t4",
"type": "umlsterm",
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DerHautarzt.70480246.eng.abstr
|
DerHautarzt.70480246.eng.abstr
|
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"text": [
"We report on two patients with granulomatous rosacea and another patient with granulomatous perioral dermatitis who responded well to dapsone . Dapsone has a pharmacological double function as both an antibiotic and an antiphlogistic drug . Before the introduction of isotretinoin , dapsone had its place in the treatment of severe acne . To date , its use in granulomatous rosacea has not been described . When hematologic parameters are monitored , dapsone is considered a safe and cost-effective drug , especially in countries where isotretinoin is not readily available . However , the definite value of dapsone in granulomatous rosacea should be established by a controlled study ."
],
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[
0,
686
]
]
}
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[] |
[] |
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] |
DerHautarzt.70480249.eng.abstr
|
DerHautarzt.70480249.eng.abstr
|
[
{
"id": "DerHautarzt.70480249.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 61-year-old woman with depression developed recurring elevated itching erythematous lesions in light-exposed areas after taking St. John's Wort-extract for three years . Routine patchtesting did not reveal any relevant reactions and photopatch testing was negative . Using a systemic oral photoprovocation test with St. John's Wort , we were able to demonstrate a decrease of the MED-UVB which was reversible after withdrawal of the medication ."
],
"offsets": [
[
0,
447
]
]
}
] |
[
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] |
[] |
[] |
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DerHautarzt.70480253.eng.abstr
|
DerHautarzt.70480253.eng.abstr
|
[
{
"id": "DerHautarzt.70480253.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Juvenile hyaline fibromatosis is a rare autosomal recessive connective tissue disease first described in 1873 by Murray . Major diagnostic criteria are multiple cutaneous tumors and gingival hypertrophy ; minor criteria include contractures , osteolytic lesions and a positive family history ."
],
"offsets": [
[
0,
293
]
]
}
] |
[
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"id": "DerHautarzt.70480253.eng.abstr-s1-t2",
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{
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},
{
"id": "DerHautarzt.70480253.eng.abstr-s2-t10",
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161,
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},
{
"id": "DerHautarzt.70480253.eng.abstr-s2-t11",
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],
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182,
202
]
],
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"db_id": "C0017567"
}
]
}
] |
[] |
[] |
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] |
DerHautarzt.70480258.eng.abstr
|
DerHautarzt.70480258.eng.abstr
|
[
{
"id": "DerHautarzt.70480258.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 12 year old boy developed the complete symptom complex of Adamantiades-Behçet's disease over a two-year period . He presented with the mucocutaneous variant with recurrent to persistent oral ulcers which extended into the pharynx , recurrent genital ulcers , perianal lesions , and a positive pathergy test . Ocular involvement and other symptoms associated with the disease were absent . However , the early onset of the disease and the male gender indicated a bad prognosis . The patients father deficiency of suffered from bronchial asthma with recurrent respiratory infections . An IgG-3 subclass was detected . Lymphocyte transformation tests showed markedly diminished response to stimulation with anti-CD3 monoclonal antibody in both patients , while response to PWM , CoA and PHA was normal . In addition , the concentration of serum soluble interleukin 6 receptor was reduced in both patients ."
],
"offsets": [
[
0,
905
]
]
}
] |
[
{
"id": "DerHautarzt.70480258.eng.abstr-s1-t1",
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]
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{
"id": "DerHautarzt.70480258.eng.abstr-s1-t2",
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"symptom"
],
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41,
48
]
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"id": "DerHautarzt.70480258.eng.abstr-s1-t3",
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"disease"
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82,
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}
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},
{
"id": "DerHautarzt.70480258.eng.abstr-s1-t4",
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"period"
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}
]
},
{
"id": "DerHautarzt.70480258.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"ulcers"
],
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193,
199
]
],
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}
]
},
{
"id": "DerHautarzt.70480258.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"pharynx"
],
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]
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}
]
},
{
"id": "DerHautarzt.70480258.eng.abstr-s2-t3",
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"text": [
"ulcers"
],
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252,
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{
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},
{
"id": "DerHautarzt.70480258.eng.abstr-s2-t5",
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"oral ulcers"
],
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188,
199
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],
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"db_id": "C0149745"
}
]
},
{
"id": "DerHautarzt.70480258.eng.abstr-s3-t1",
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"symptoms"
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"id": "DerHautarzt.70480258.eng.abstr-s3-t2",
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},
{
"id": "DerHautarzt.70480258.eng.abstr-s4-t2",
"type": "umlsterm",
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"male"
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},
{
"id": "DerHautarzt.70480258.eng.abstr-s4-t3",
"type": "umlsterm",
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}
]
},
{
"id": "DerHautarzt.70480258.eng.abstr-s4-t4",
"type": "umlsterm",
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"prognosis"
],
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]
},
{
"id": "DerHautarzt.70480258.eng.abstr-s4-t5",
"type": "umlsterm",
"text": [
"male gender"
],
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440,
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],
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},
{
"id": "DerHautarzt.70480258.eng.abstr-s5-t1",
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},
{
"id": "DerHautarzt.70480258.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
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}
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},
{
"id": "DerHautarzt.70480258.eng.abstr-s5-t3",
"type": "umlsterm",
"text": [
"deficiency"
],
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},
{
"id": "DerHautarzt.70480258.eng.abstr-s5-t4",
"type": "umlsterm",
"text": [
"asthma"
],
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},
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"id": "DerHautarzt.70480258.eng.abstr-s5-t5",
"type": "umlsterm",
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"infections"
],
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},
{
"id": "DerHautarzt.70480258.eng.abstr-s5-t6",
"type": "umlsterm",
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"bronchial asthma"
],
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},
{
"id": "DerHautarzt.70480258.eng.abstr-s5-t7",
"type": "umlsterm",
"text": [
"respiratory infections"
],
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},
{
"id": "DerHautarzt.70480258.eng.abstr-s7-t1",
"type": "umlsterm",
"text": [
"Lymphocyte"
],
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"id": "DerHautarzt.70480258.eng.abstr-s7-t2",
"type": "umlsterm",
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},
{
"id": "DerHautarzt.70480258.eng.abstr-s7-t3",
"type": "umlsterm",
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{
"id": "DerHautarzt.70480258.eng.abstr-s7-t5",
"type": "umlsterm",
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},
{
"id": "DerHautarzt.70480258.eng.abstr-s7-t6",
"type": "umlsterm",
"text": [
"CoA"
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},
{
"id": "DerHautarzt.70480258.eng.abstr-s7-t7",
"type": "umlsterm",
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},
{
"id": "DerHautarzt.70480258.eng.abstr-s7-t8",
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],
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],
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}
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},
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"id": "DerHautarzt.70480258.eng.abstr-s7-t9",
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"monoclonal antibody"
],
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},
{
"id": "DerHautarzt.70480258.eng.abstr-s8-t2",
"type": "umlsterm",
"text": [
"interleukin"
],
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},
{
"id": "DerHautarzt.70480258.eng.abstr-s8-t4",
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{
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]
}
] |
[] |
[] |
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{
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},
{
"id": "DerHautarzt.70480258.eng.abstr-s7-r34-t9.1-t6.1",
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},
{
"id": "DerHautarzt.70480258.eng.abstr-s7-r35-t1.1-t7.1",
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},
{
"id": "DerHautarzt.70480258.eng.abstr-s7-r36-t8.1-t2.1",
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},
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},
{
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},
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"id": "DerHautarzt.70480258.eng.abstr-s7-r39-t6.1-t5.1",
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},
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},
{
"id": "DerHautarzt.70480258.eng.abstr-s8-r1-t1.1-t4.7",
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},
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},
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},
{
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},
{
"id": "DerHautarzt.70480258.eng.abstr-s8-r8-t1.1-t4.3",
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}
] |
DerHautarzt.70480262.eng.abstr
|
DerHautarzt.70480262.eng.abstr
|
[
{
"id": "DerHautarzt.70480262.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 76 year old patient with actinic reticuloid was treated with Cyclosporin A. 11 months after beginning the immunosuppressive therapy , he developed lymphoedema and livid nodular skin lesions of the right leg , which histologically showed Kaposi's sarcoma . After stopping the Cyclosporin A and intralesional therapy with Interferon alpha , no regression of the Kaposi sarcoma could be seen . The characteristics of Kaposi sarcoma arising during immunosuppressive therapy and the differences in incidence , risk groups and distribution pattern compared to the classic sporadic and the AIDS-related Kaposi sarcoma will be described . The development of Kaposi sarcoma during immunosuppressive therapy for actinic reticuloid has not been previously described ."
],
"offsets": [
[
0,
758
]
]
}
] |
[
{
"id": "DerHautarzt.70480262.eng.abstr-s1-t1",
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"old"
],
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10,
13
]
],
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"db_id": "C0331059"
}
]
},
{
"id": "DerHautarzt.70480262.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"patient"
],
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[
14,
21
]
],
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{
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"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.70480262.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"Cyclosporin"
],
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[
63,
74
]
],
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{
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"db_id": "C0010592"
},
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"db_id": "C0010594"
}
]
},
{
"id": "DerHautarzt.70480262.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"immunosuppressive"
],
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108,
125
]
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]
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{
"id": "DerHautarzt.70480262.eng.abstr-s1-t5",
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"therapy"
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126,
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}
]
},
{
"id": "DerHautarzt.70480262.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"lymphoedema"
],
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149,
160
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"db_id": "C0024236"
}
]
},
{
"id": "DerHautarzt.70480262.eng.abstr-s1-t7",
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"text": [
"skin"
],
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179,
183
]
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]
},
{
"id": "DerHautarzt.70480262.eng.abstr-s1-t8",
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"right"
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199,
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}
]
},
{
"id": "DerHautarzt.70480262.eng.abstr-s1-t9",
"type": "umlsterm",
"text": [
"leg"
],
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[
205,
208
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],
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"db_id": "C0023216"
}
]
},
{
"id": "DerHautarzt.70480262.eng.abstr-s1-t10",
"type": "umlsterm",
"text": [
"sarcoma"
],
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248,
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]
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"db_id": "C0036210"
}
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},
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"id": "DerHautarzt.70480262.eng.abstr-s1-t11",
"type": "umlsterm",
"text": [
"immunosuppressive therapy"
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108,
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}
]
},
{
"id": "DerHautarzt.70480262.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"Cyclosporin"
],
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277,
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}
]
},
{
"id": "DerHautarzt.70480262.eng.abstr-s2-t2",
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"therapy"
],
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}
]
},
{
"id": "DerHautarzt.70480262.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"Interferon"
],
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322,
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],
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"db_id": "C0021747"
}
]
},
{
"id": "DerHautarzt.70480262.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"alpha"
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"db_name": "UMLS",
"db_id": "C0002210"
},
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"db_name": "UMLS",
"db_id": "C0002211"
}
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},
{
"id": "DerHautarzt.70480262.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"regression"
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]
},
{
"id": "DerHautarzt.70480262.eng.abstr-s2-t6",
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"text": [
"sarcoma"
],
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]
},
{
"id": "DerHautarzt.70480262.eng.abstr-s2-t7",
"type": "umlsterm",
"text": [
"Cyclosporin A"
],
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277,
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},
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"id": "DerHautarzt.70480262.eng.abstr-s2-t8",
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"Interferon alpha"
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]
},
{
"id": "DerHautarzt.70480262.eng.abstr-s2-t9",
"type": "umlsterm",
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"Kaposi sarcoma"
],
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"id": "DerHautarzt.70480262.eng.abstr-s3-t1",
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"sarcoma"
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423,
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{
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"immunosuppressive"
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"therapy"
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},
{
"id": "DerHautarzt.70480262.eng.abstr-s3-t4",
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"incidence"
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{
"id": "DerHautarzt.70480262.eng.abstr-s3-t5",
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},
{
"id": "DerHautarzt.70480262.eng.abstr-s3-t6",
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},
{
"id": "DerHautarzt.70480262.eng.abstr-s3-t7",
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"text": [
"AIDS-related"
],
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]
},
{
"id": "DerHautarzt.70480262.eng.abstr-s3-t8",
"type": "umlsterm",
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],
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},
{
"id": "DerHautarzt.70480262.eng.abstr-s3-t11",
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},
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},
{
"id": "DerHautarzt.70480262.eng.abstr-s4-t2",
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]
},
{
"id": "DerHautarzt.70480262.eng.abstr-s4-t3",
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},
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]
},
{
"id": "DerHautarzt.70480262.eng.abstr-s4-t5",
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"Kaposi sarcoma"
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{
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}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.70480262.eng.abstr-s1-r1-t3.1-t10.1",
"type": "affects",
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"normalized": []
},
{
"id": "DerHautarzt.70480262.eng.abstr-s1-r2-t3.2-t7.1",
"type": "disrupts",
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"arg2_id": "DerHautarzt.70480262.eng.abstr-s3-t7",
"normalized": []
},
{
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"type": "interacts_with",
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"arg2_id": "DerHautarzt.70480262.eng.abstr-s4-t4",
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},
{
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},
{
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},
{
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},
{
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},
{
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] |
DerHautarzt.70480266.eng.abstr
|
DerHautarzt.70480266.eng.abstr
|
[
{
"id": "DerHautarzt.70480266.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A case of tufted hair folliculutis presenting as circumscribed , tender and inflamed areas in the occiput with residual tufted follicles in a 28-year old man is reported . Tufted hair folliculitis is a characteristic localized scarring bacterial folliculitis of the scalp due to Staphylococcus aureus . Histopathological studies reveal perifollicular inflammation around the upper portions of the follicles sparing the hair root level . Within areas of inflammation , several follicles converge toward a common follicular duct with a widely dilated opening . Currently , tufted hair folliculitis is considered a variant of folliculitis decalvans of Quinquaud . Staphylococcal infection is believed to be an initial causative factor , and underlying differences in follicular anatomy or host response may be important in determining which reaction pattern occurs in an affected individual . The development of atrophy with loss of adnexal structures ( in folliculitis decalvans ) or of hair tufts ( in tufting folliculitis ) may depend upon the depth and destructive potential of the inflammatory process . The therapeutic approach is problematic ; prolonged treatment with oral antibiotics may stabilize the disease , but good and at times more definitive results ( as in the presented case ) have been reported after radical surgical excision of the involved areas ."
],
"offsets": [
[
0,
1367
]
]
}
] |
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21
]
],
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}
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},
{
"id": "DerHautarzt.70480266.eng.abstr-s1-t2",
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"follicles"
],
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127,
136
]
],
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},
{
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"old"
],
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]
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{
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"man"
],
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]
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{
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"id": "DerHautarzt.70480266.eng.abstr-s2-t3",
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{
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},
{
"id": "DerHautarzt.70480266.eng.abstr-s2-t5",
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"scalp"
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},
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},
{
"id": "DerHautarzt.70480266.eng.abstr-s3-t2",
"type": "umlsterm",
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],
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},
{
"id": "DerHautarzt.70480266.eng.abstr-s3-t3",
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{
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{
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{
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"normalized": []
}
] |
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