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DerHautarzt.40450402.eng.abstr
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DerHautarzt.40450402.eng.abstr
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"Abstract . Mycetomas are subacute or chronic infections usually localized on unprotected skin areas and caused by fungi or Actinomyces . We report the case of a patient who suffered a splinter injury on his wrist after a motor accident . Six months later a cutaneous abscess with Actinobacillus acinomycetemcomitans developed on his wrist . Complete healing was obtained within 1 month after administration of ceftriaxon and doxycycline . The therapeutic management will be discussed ."
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DerHautarzt.40450406.eng.abstr
|
DerHautarzt.40450406.eng.abstr
|
[
{
"id": "DerHautarzt.40450406.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . It is rare for solitary basal cell cancer not to be associated with the naevoid basal cell carcinoma syndrome ( NBCCS ) , xeroderma pigmentosum , an organoid nevus or X-ray therapy in children ( to date 86 cases have been documented in the literature ) . Aetiologically , the tumours might be a forme fruste of the NBCCS or they might follow a somatic point mutation of keratinocytes . Up to now , data on the repair mechanism following UV-induced DNA damage are not available in these patients . We report on a 10-year-old boy with a solitary nodular basal cell cancer in the right malar region . Neither the patient's history nor the clinical findings suggested a genetic disposition to development of the tumour ."
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DerHautarzt.40450445.eng.abstr
|
DerHautarzt.40450445.eng.abstr
|
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"Since the identification of the cholesterol derivative 1,25-dihydroxy-vitamin D3 and its analogues as potent immunomodulatory , proliferation- and differentiation-regulatory molecules , the amount of data available on the effects of these agents on the skin and its appendages has grown exponentially . This review outlines recent progress in the understanding of the molecular biology and pathophysiology of vitamin D , and new strategies for the treatment of skin diseases are discussed . Focusing on psoriasis and preliminary clinical experience , we discuss possible therapeutic targets and perspectives for these multifunctional steroid hormones in dermatology ."
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[] |
[] |
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DerHautarzt.40450453.eng.abstr
|
DerHautarzt.40450453.eng.abstr
|
[
{
"id": "DerHautarzt.40450453.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Burns caused by exposure to hydrofluoric acid are characterized by severe progressive tissue destruction and excruciating pain resulting from the unique properties of the fluoride ion . The subungual tissues are especially susceptible to the destructive effects of hydrofluoric acid . Therefore , proper treatment of hydrofluoric acid burns requires prompt recognition and the institution of specific therapeutic measures by the attending dermatologist ."
],
"offsets": [
[
0,
454
]
]
}
] |
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],
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]
],
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}
]
},
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],
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]
],
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],
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92
]
],
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]
],
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},
{
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],
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]
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{
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],
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[] |
[] |
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] |
DerHautarzt.40450460.eng.abstr
|
DerHautarzt.40450460.eng.abstr
|
[
{
"id": "DerHautarzt.40450460.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Since 1983 the administration of phenylalanine combined with UVA exposure ( PAUVA ) has been a well-known therapy for vitiligo . We have found no retrospective studies on this therapy . To document the long-term results and side effects , we performed a retrospective study on 41 patients who had received PAUVA therapy about 5 years ago . Examination was possible in 25 of the 41 patients , and 11 of them ( 44% ) had permanent repigmentation . Depigmentation either during or after PAUVA therapy was recognized in 16 of the 25 patients ( 64% ) . In 52% of cases the patients were satisfied with the therapy and would repeat it ; 68% would recommend it . Positive features in prognosis , i.e. indicative of good repigmentation , were vitiligo extending over less than 25% of the body surface , onset of vitiligo before the age of 21 , generalized and symmetrical distribution and a long duration of UV therapy . None of our patients developed long-term side effects . PAUVA therapy is demonstrably a therapeutic alternative for certain patients ."
],
"offsets": [
[
0,
1047
]
]
}
] |
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"patients"
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280,
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[] |
[] |
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] |
DerHautarzt.40450468.eng.abstr
|
DerHautarzt.40450468.eng.abstr
|
[
{
"id": "DerHautarzt.40450468.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In malignant melanoma , melanocyte-stimulating hormone ( -MSH ) has been found to influence the cellular metabolism of melanoma cells ( c-AMP production , protein and RNA synthesis , and tyrosinase activation ) . In some publications elevated -MSH levels have been described in melanoma patients . In the present study we used a commercially available radioimmunoassay to examine the -MSH levels in patients with malignant melanoma and a control group consisting of apparently healthy volunteers ( laboratory assistants ) and dermatological patients without malignant tumours . The plasma -MSH levels were ( x\\= +/- SD ) 12.2 +/- 12.9 for 37 melanoma patients ( 17 female , 20 male ) and 7.9 +/- 3.5 pmol/l for 38 control persons ( 18 female , 20 male ) . The difference is significant according to the distribution-free U-test of Mann and Whitney . In 13 ( 35% ) of the melanoma patients values were above the normal range defined by the 95.5% confidence limit . -MSH cannot be classified as a typical tumour marker . Nonetheless , in our opinion -MSH levels may be useful in monitoring melanoma patients with reference to prognosis and follow up during and after therapy ."
],
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]
}
] |
[] |
[] |
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] |
DerHautarzt.40450471.eng.abstr
|
DerHautarzt.40450471.eng.abstr
|
[
{
"id": "DerHautarzt.40450471.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Progressive systemic scleroderma ( PSS ) is caused by generalized connective tissue disorder . The most frequent visceral manifestations are pulmonary and oesophageal involvement . Early detection of such visceral manifestations , which are sometimes life-limiting , is of paramount importance in any diagnostic procedures . The sensitivity of the methods differs and depends on the stage of the disease . Modified high-resolution computed tomographic scans ( HRCT ) were obtained in 28 patients with early forms of PSS and showed pulmonary involvement in 79% and signs of oesophageal involvement in 54% . HRCT is much more sensitive than chest radiography , lung scintigraphy and lung function tests even at an early stage of the disease . Classification of PSS should take account of the clinical type of sclerosis and of immunological and other parameters of prognostic importance ."
],
"offsets": [
[
0,
885
]
]
}
] |
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{
"id": "DerHautarzt.40450471.eng.abstr-s1-t2",
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DerHautarzt.40450476.eng.abstr
|
DerHautarzt.40450476.eng.abstr
|
[
{
"id": "DerHautarzt.40450476.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report on a 45-year-old male patient who presented with classic cutaneous polyarteritis nodosa ( PAN ) . The clinical course extended over 7 years . In spite of 2 years of immunosuppressive therapy with azathioprine and methylprednisolone the course was progressive . Low-dose methotrexate therapy was the only treatment that controlled the disease , leading to rapid clinical and histopathological remission . In low concentrations methotrexate acts as an IL-1 inhibitor , and it obviously suppresses the pathogenetic mechanism of PAN ."
],
"offsets": [
[
0,
540
]
]
}
] |
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}
] |
[] |
[] |
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{
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{
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}
] |
DerHautarzt.40450484.eng.abstr
|
DerHautarzt.40450484.eng.abstr
|
[
{
"id": "DerHautarzt.40450484.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 53-year-old female patient developed disseminated , filiform keratoses up to 4 mm long on the back , arms and neck and upper thorax for the first time 10 years ago . There were no associated diseases or symptoms . Treatment with etretinate was successful . After discontinuing this therapy the patient had a relapse . With this observation we bring new arguments into the discussion on filiforme keratoses ."
],
"offsets": [
[
0,
409
]
]
}
] |
[
{
"id": "DerHautarzt.40450484.eng.abstr-s1-t1",
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"female"
],
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14,
20
]
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"db_id": "C0015780"
}
]
},
{
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},
{
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"keratoses"
],
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63,
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"db_id": "C0022593"
}
]
},
{
"id": "DerHautarzt.40450484.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"back"
],
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96,
100
]
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"db_id": "C0004600"
}
]
},
{
"id": "DerHautarzt.40450484.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"arms"
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103,
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"db_id": "C0003792"
}
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"text": [
"neck"
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112,
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"db_id": "C0027530"
}
]
},
{
"id": "DerHautarzt.40450484.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"thorax"
],
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127,
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]
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"db_id": "C0039992"
}
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"type": "umlsterm",
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"time"
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"db_id": "C0012634"
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{
"id": "DerHautarzt.40450484.eng.abstr-s2-t2",
"type": "umlsterm",
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"symptoms"
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"id": "DerHautarzt.40450484.eng.abstr-s2-t3",
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"id": "DerHautarzt.40450484.eng.abstr-s3-t1",
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"Treatment"
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]
},
{
"id": "DerHautarzt.40450484.eng.abstr-s3-t2",
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"etretinate"
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"db_id": "C0015137"
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},
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"id": "DerHautarzt.40450484.eng.abstr-s4-t2",
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},
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"id": "DerHautarzt.40450484.eng.abstr-s5-t1",
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{
"id": "DerHautarzt.40450484.eng.abstr-s5-t2",
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}
] |
[] |
[] |
[
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{
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{
"id": "DerHautarzt.40450484.eng.abstr-s2-r1-t2.1-t3.1",
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{
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{
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{
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{
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{
"id": "DerHautarzt.40450484.eng.abstr-s2-r6-t3.1-t1.1",
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},
{
"id": "DerHautarzt.40450484.eng.abstr-s5-r1-t2.1-t1.1",
"type": "associated_with",
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},
{
"id": "DerHautarzt.40450484.eng.abstr-s5-r2-t1.1-t2.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.40450484.eng.abstr-s5-t1",
"arg2_id": "DerHautarzt.40450484.eng.abstr-s5-t2",
"normalized": []
}
] |
DerHautarzt.40450489.eng.abstr
|
DerHautarzt.40450489.eng.abstr
|
[
{
"id": "DerHautarzt.40450489.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report on the case of a 75-year-old woman patient with tuberculosis colliquativa cutis ( scrofuloderma ) . The skin lesions had developed from a cervical lymph node tuberculosis . The diagnosis was made by culturing biopsied skin and underlying lymph node . Under a triple drug regimen the skin lesions cleared within 2 months . Lymph nodes appeared to be normal after 6 months . Diagnostic and therapeutic approaches to scrofuloderma and cervical lymph node tuberculosis are discussed ."
],
"offsets": [
[
0,
490
]
]
}
] |
[
{
"id": "DerHautarzt.40450489.eng.abstr-s1-t1",
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"text": [
"woman"
],
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39,
44
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],
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"db_id": "C0043210"
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},
{
"id": "DerHautarzt.40450489.eng.abstr-s1-t2",
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}
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},
{
"id": "DerHautarzt.40450489.eng.abstr-s1-t3",
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"text": [
"tuberculosis"
],
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58,
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"db_id": "C0041296"
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]
},
{
"id": "DerHautarzt.40450489.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"tuberculosis colliquativa"
],
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58,
83
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],
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"db_name": "UMLS",
"db_id": "C0275934"
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},
{
"id": "DerHautarzt.40450489.eng.abstr-s1-t5",
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58,
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{
"id": "DerHautarzt.40450489.eng.abstr-s2-t1",
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"skin"
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114,
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"db_id": "C0037267"
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},
{
"id": "DerHautarzt.40450489.eng.abstr-s2-t2",
"type": "umlsterm",
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"lymph"
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157,
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"db_id": "C0024202"
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"id": "DerHautarzt.40450489.eng.abstr-s2-t3",
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{
"id": "DerHautarzt.40450489.eng.abstr-s2-t4",
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157,
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]
},
{
"id": "DerHautarzt.40450489.eng.abstr-s2-t5",
"type": "umlsterm",
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"lymph node tuberculosis"
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157,
180
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"db_id": "C0041316"
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},
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"id": "DerHautarzt.40450489.eng.abstr-s3-t1",
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"id": "DerHautarzt.40450489.eng.abstr-s3-t2",
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"id": "DerHautarzt.40450489.eng.abstr-s4-t2",
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},
{
"id": "DerHautarzt.40450489.eng.abstr-s5-t1",
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{
"id": "DerHautarzt.40450489.eng.abstr-s5-t2",
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"Lymph nodes"
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332,
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},
{
"id": "DerHautarzt.40450489.eng.abstr-s6-t1",
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{
"id": "DerHautarzt.40450489.eng.abstr-s6-t2",
"type": "umlsterm",
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"therapeutic"
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398,
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"id": "DerHautarzt.40450489.eng.abstr-s6-t3",
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"lymph"
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451,
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{
"id": "DerHautarzt.40450489.eng.abstr-s6-t4",
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{
"id": "DerHautarzt.40450489.eng.abstr-s6-t5",
"type": "umlsterm",
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"lymph node"
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[
451,
461
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},
{
"id": "DerHautarzt.40450489.eng.abstr-s6-t6",
"type": "umlsterm",
"text": [
"lymph node tuberculosis"
],
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[
451,
474
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],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0041316"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.40450489.eng.abstr-s1-r1-t1.1-t2.1",
"type": "interacts_with",
"arg1_id": "DerHautarzt.40450489.eng.abstr-s6-t1",
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{
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DerHautarzt.40450494.eng.abstr
|
DerHautarzt.40450494.eng.abstr
|
[
{
"id": "DerHautarzt.40450494.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In a 39-year-old woman an anticonvulsant therapy was initiated because of focal attacks in the left arm and face . The patient experienced generalized maculopapular skin rashes in response to each of four chemically similar anticonvulsant drugs : phenytoin , carbamazepine , primidone and clonazepam . During administration of carbamazepine the clinical features included fever , hepatitis and haemotological eosinophilia in addition to the skin rash ( anticonvulsant hypersensitivity syndrome ) . The anticonvulsant hypersensitivity syndrome is defined as an idiosyncratic reaction caused by disturbed drug metabolism . Positive lymphocytetransformation tests with carbamazepine and phenytoin indicate an immunological mechanism underlying the rashes in our patient . Patch testing with the four anticonvulsant drugs gave positive results only with carbamazepine . Skin biopsy showed the histological features of a delayed-type allergy . The anticonvulsant therapy was continued with a chemically unrelated preparation , valproic acid ; this drug is well tolerated and has proved appropriate for prevention of seizures ."
],
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0,
1121
]
]
}
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[] |
[] |
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DerHautarzt.40450499.eng.abstr
|
DerHautarzt.40450499.eng.abstr
|
[
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"id": "DerHautarzt.40450499.eng.abstr-passage-0",
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"This report deals with a 15-year-old girl suffering from the verrucous type of Thomson's syndrome . Initial poikilodermatous skin changes developed on both cheeks at the age of 3 months . Subsequently , rapid generalization of typical skin findings was observed . The clinical heterogenity of this syndrome is discussed with reference to the existing literature and the present case . Up to now , very few comparable cases of associated neurological symptoms have been described ."
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[] |
[] |
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DerHautarzt.40450517.eng.abstr
|
DerHautarzt.40450517.eng.abstr
|
[
{
"id": "DerHautarzt.40450517.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . Ultraviolet light is frequently used for cosmetic tanning of the skin . UV light is known to be carcinogenic , but this is attributed predominantly to short-wavelength UV radiation ( UVB ) . However , new data indicate a carcinogenic role for long wavelength ultraviolet light ( UVA ) also . In vitro studies have demonstrated DNA-damaging effects of UVA . In animals squamous cell carcinomas and melanomas were induced by UVA alone or in combination with UVB . Reference to a possible carcinogenicity of UVA may also be derived from the therapeutic application of UVA together with psoralens ( PUVA ) . In addition , recent epidemiological studies have associated the use of sunbeds with the development of malignant melanoma . In conclusion , the carcinogenicity of UVA in humans cannot be ruled out , but requires further validation . Long and repeated UVA exposure should be discouraged , because of the far-reaching risks involved ."
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[] |
[] |
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DerHautarzt.40450526.eng.abstr
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DerHautarzt.40450526.eng.abstr
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[] |
[] |
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DerHautarzt.40450532.eng.abstr
|
DerHautarzt.40450532.eng.abstr
|
[
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"text": [
"Abstract . Microfilm photography allows documentation of naevi in a map-like fashion . The localization of multiple naevi is no longer a problem , as one can scan the film . Comparison of the magnified film with the patient can be done in day-light . Magnification up to 48 times is possible . Detection of early changes of the naevi , during the horizontal growth phase , should increase the 5-year survival rate ."
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[] |
[] |
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DerHautarzt.40450536.eng.abstr
|
DerHautarzt.40450536.eng.abstr
|
[
{
"id": "DerHautarzt.40450536.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . Since the immune system plays an important role in the rejection of tumours , current tumour therapy includes immunostimulation . This can be done by interleukin 2 ( Il-2), which activates T and killer cells and induces lysis of the tumour . Because the intravenous application of Il-2 may have serious side effects , we treated two patients with peritumoral injections in a pilot study . Both patients suffered from multiple cutaneous metastases of melanoma . A total of 31 and 39x106 IU recombinant Il-2 ( Proleukin ) respectively was injected in increasing concentrations in one metastasis of each patient . Histologically , almost complete necrosis of the tumour was induced . In comparison with the control specimen , the T-cell-rich infiltrate increased intra- and , in particular , peritumorally . While the ratio of helper to suppressor T cells remained unchanged , the proportions of NK cells , monocytes/macrophages and IL-2-receptor-bearing cells increased . This reaction was restricted to treated metastases . No clinical side effects or laboratory changes were registered apart from local erythema and swelling ."
],
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0,
1137
]
]
}
] |
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] |
[] |
[] |
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DerHautarzt.40450546.eng.abstr
|
DerHautarzt.40450546.eng.abstr
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"id": "DerHautarzt.40450546.eng.abstr-passage-0",
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"Abstract . Profilometry is a novel procedure allowing precise analysis of skin surface structure . With the help of a synthetic material a negative image of a defined area of the skin is taken . During the subsequent analytical procedure the roughness is determined by means of a profilometer . A commercially available statistics software program is used for statistical analysis of the results . This procedure was applied to check for to evaluate positive effects of oestrogen creams on the structure of the skin surface on the face ."
],
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0,
537
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]
}
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] |
[] |
[] |
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DerHautarzt.40450551.eng.abstr
|
DerHautarzt.40450551.eng.abstr
|
[
{
"id": "DerHautarzt.40450551.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . A 62-year-old woman developed eosinophilic cellulitis of her right arm , accompanied by systemic signs ( fever , leucocytosis ) and massive restriction of the motility of her right shoulder joint . Sonography and computed tomography revealed massive cutaneous and subcutaneous oedema , and accumulations of fluid around the deep muscular fasciae , interstices and ( less severe ) within the joint . High-dose systemic corticosteroid treatment led to rapid clearing of the skin lesions , and joint motility was restored several weeks later . This is the first case of eosinophilic cellulitis in which involvement of deep structures adjacent to joints has been demonstrated by modern imaging techniques ."
],
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[
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] |
DerHautarzt.40450554.eng.abstr
|
DerHautarzt.40450554.eng.abstr
|
[
{
"id": "DerHautarzt.40450554.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . Xeroderma pigmentosum comprises a heterogeneous group of autosomal recessive hereditary diseases , which are characterized by a number of clinical characteristics and an abnormal DNA repair mechanism . Patients affected show a high frequency of mucocutaneous malignant tumours , especially squamous cell carcinomas and basal cell carcinomas . We report on a 65-year-old patient who successively developed a total of 15 malignant melanomas , 1 squamous cell carcinoma and 1 lymph node metastasis of a malignant melanoma . The clinical diagnosis of xeroderma pigmentosum was confirmed by the complementation analysis , which defined our patient as xeroderma pigmentosum of the complementation group D."
],
"offsets": [
[
0,
710
]
]
}
] |
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"Xeroderma"
],
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11,
20
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"id": "DerHautarzt.40450554.eng.abstr-s2-t2",
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"diseases"
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"id": "DerHautarzt.40450554.eng.abstr-s2-t3",
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"DNA"
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190,
193
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"id": "DerHautarzt.40450554.eng.abstr-s2-t4",
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"repair"
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"id": "DerHautarzt.40450554.eng.abstr-s2-t5",
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"Xeroderma pigmentosum"
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11,
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"id": "DerHautarzt.40450554.eng.abstr-s2-t6",
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"hereditary diseases"
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"id": "DerHautarzt.40450554.eng.abstr-s2-t7",
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"DNA repair"
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190,
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"id": "DerHautarzt.40450554.eng.abstr-s3-t1",
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"Patients"
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{
"id": "DerHautarzt.40450554.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"frequency"
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[
243,
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"db_id": "C0376249"
}
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"id": "DerHautarzt.40450554.eng.abstr-s3-t3",
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"text": [
"malignant"
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270,
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"id": "DerHautarzt.40450554.eng.abstr-s3-t4",
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"id": "DerHautarzt.40450554.eng.abstr-s3-t5",
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"id": "DerHautarzt.40450554.eng.abstr-s3-t6",
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"id": "DerHautarzt.40450554.eng.abstr-s3-t7",
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"id": "DerHautarzt.40450554.eng.abstr-s3-t9",
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"id": "DerHautarzt.40450554.eng.abstr-s3-t10",
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"id": "DerHautarzt.40450554.eng.abstr-s3-t11",
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330,
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"id": "DerHautarzt.40450554.eng.abstr-s4-t2",
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"id": "DerHautarzt.40450554.eng.abstr-s4-t3",
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"melanomas"
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"id": "DerHautarzt.40450554.eng.abstr-s4-t4",
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"cell"
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"id": "DerHautarzt.40450554.eng.abstr-s4-t5",
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"id": "DerHautarzt.40450554.eng.abstr-s4-t6",
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"id": "DerHautarzt.40450554.eng.abstr-s4-t9",
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"id": "DerHautarzt.40450554.eng.abstr-s4-t10",
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430,
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"db_name": "UMLS",
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"id": "DerHautarzt.40450554.eng.abstr-s4-t11",
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"lymph node"
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"id": "DerHautarzt.40450554.eng.abstr-s4-t12",
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"id": "DerHautarzt.40450554.eng.abstr-s5-t2",
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{
"id": "DerHautarzt.40450554.eng.abstr-s5-t6",
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"id": "DerHautarzt.40450554.eng.abstr-s5-t7",
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}
] |
[] |
[] |
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DerHautarzt.40450562.eng.abstr
|
DerHautarzt.40450562.eng.abstr
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"Abstract . A 62-year-old female patient presented with bullous , intensely itching cutaneous lesions , which clinically and histopathologically resembled dermatitis herpetiformis ( Duhring's disease ) . Therapy with DADPS was unsuccessful . Because of associated cervical lymph node enlargement and splenomegaly , a lymph node biopsy was taken . Histopathology of a lymph node and of the bone marrow confirmed the diagnosis : angioimmunoblastic lymphadenopathy ( AILD ) -type T-cell lymphoma . Intensely pruritic associated skin eruptions are typical for this peculiar kind of lymphoma . These skin lesions are due to inflammatory cells and not to neoplastic infiltrations . This case report is the first report of AILD with bullous skin lesions to appear in the literature ."
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[] |
[] |
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DerHautarzt.40450566.eng.abstr
|
DerHautarzt.40450566.eng.abstr
|
[
{
"id": "DerHautarzt.40450566.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . A case of a 37-year-old woman with symmetrical bilateral apocrine hidrocystomas at the lateral margins of the eyelids is presented . The symmetrical , simultaneous and bilateral appearance of the lesions , the lack of association with other abnormalities and the absence of the lesion in the family history make this case remarkable ."
],
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0,
345
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]
}
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"hidrocystomas"
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"id": "DerHautarzt.40450566.eng.abstr-s2-t3",
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"eyelids"
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] |
[] |
[] |
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DerHautarzt.40450569.eng.abstr
|
DerHautarzt.40450569.eng.abstr
|
[
{
"id": "DerHautarzt.40450569.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . A case of generalized maculopapular rash and local indurated plaques following s.c. injections of either low-molecular-weight heparin or conventional ( high-molecular-weight ) heparin to a 75-year-old woman is reported . This rare reaction is described and the literature to date is reviewed ."
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0,
304
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]
}
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"id": "DerHautarzt.40450569.eng.abstr-s2-t1",
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{
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"id": "DerHautarzt.40450569.eng.abstr-s2-t7",
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] |
[] |
[] |
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DerHautarzt.40450611.eng.abstr
|
DerHautarzt.40450611.eng.abstr
|
[
{
"id": "DerHautarzt.40450611.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . A man presented with 100% immotile spermatozoa . Transmission electron microscopy showed the absence of both central tubules in all sperm tails ; the nine peripheral tubules , dynein arms , radial spokes and other structures of the sperm tail were normal . Immotile cilia syndrome of the 9+0 tubular pattern was diagnosed . Other anomalies frequently associated with immotile cilia syndrome , such as recurrent airway infections , bronchiectases and situs inversus ( Kartagener's syndrome ) , were not present in this case ."
],
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[
0,
535
]
]
}
] |
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DerHautarzt.40450615.eng.abstr
|
DerHautarzt.40450615.eng.abstr
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"Abstract . Nine medical centres with different practices in elective lymph node dissection ( ELND ) but comparable standards regarding diagnosis , excision of the primary tumour , classification , and follow-up , have collected their data on 3616 patients with primary melanoma of the skin ( tumour category pT 2 to pT 4 a , N 0 , M 0 [ UICC 1987 ] ) with the aim of producing an unbiased analysis of the prognostic benefit of ELND . The multivariate risk analysis ( Cox's proportional hazard model ) revealed tumour thickness ( Breslow or alternative pT categories ) , sex , anatomic site of the primary tumour , and ELND therapy ( \" yes \" or \" no \" ) as independent prognostic factors . Observed survival curves ( Kaplan-Meier ) show a significant difference of prognosis with regard to ELND therapy in the following risk groups : women with melanomas over 2.5 to 4 mm thick on head , neck , thorax , and in acral locations ; men with melanomas over 1.5 to 4 mm thick on head , neck , thorax , and in acral locations ; and finally men with melanomas over 2.5 to 4 mm thick on abdomen and extremities . Further investigations and the discovery of additional prognostic factors would help in more precisely formulation of guidelines for ELND ."
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DerHautarzt.40450623.eng.abstr
|
DerHautarzt.40450623.eng.abstr
|
[
{
"id": "DerHautarzt.40450623.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . Some 456 patients with HIV-associated skin disorders were documented in the HIV follow-up clinics at the Department of Dermatology , University Medical Center Steglitz , Berlin , during the years 1982 - 1992. Males comprised 91% of the patients . The most important risk groups for HIV infection were homosexual and bisexual men ( 77.9% ) and individuals with intravenous drug abuse ( 12.7% ) . The most frequent dermatological diagnoses were oral candidosis ( 44.5% ) , seborrhoeic dermatitis ( 38.6% ) , folliculitis ( 32.9% ) and Kaposi's sarcoma ( 23.5% ) . Altogether , 138 of the patients died during the time of observation . The most frequent cause of death was disseminated Kaposi's sarcoma ( 26.8% ) . A significant proportion of the patients developed skin diseases before significant reduction of the circulating CD4+ lymphocytes . In a still satisfactory immune situation , predominantly infections of the skin with dermatophytes ( tinea ) , human papilloma viruses ( warts ) and bacteria ( pyodermas ) were observed . A considerable number of the HIV patients who developed zoster were also still in a favourable immune status ; another 50% of these cases , however , developed the disease with reduced CD4+ lymphocyte count ( 300/µl). Skin manifestations that tended to occur later in the course of HIV infection were oral candidosis , oral hairy leukoplakia , herpes genitoanalis , mollusca contagiosa and Kaposi's sarcoma , in spite of their early appearance in some cases . In the large majority of these patients the immunological parameters were already clearly reduced . Fungal , bacterial and viral infections of the skin , especially with extended skin involvement , may manifest themselves during the early phases of HIV infection . The number and severity of the skin manifestations increase with progressing immunosuppression , and treatment is often a difficult challenge for the dermatologist ."
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},
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}
] |
DerHautarzt.40450630.eng.abstr
|
DerHautarzt.40450630.eng.abstr
|
[
{
"id": "DerHautarzt.40450630.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . The degree of lipodermatosclerosis in chronic venous insufficiency was determined by high-resolution 20 MHz ultrasound . For comparison , skin biopsies were taken and examined by light microscopy . With increasingly extensive sclerosis , ultrasound showed increasing thickness of the dermis with a poorly defined border from the subcutaneous fat . In addition , an echolucent band appeared in the upper dermis , corresponding to regions of glomerular capillaries in histology . In our experience , high-resolution ultrasound examination allows rapid and objective quantification of lipodermatosclerosis ."
],
"offsets": [
[
0,
615
]
]
}
] |
[
{
"id": "DerHautarzt.40450630.eng.abstr-s1-t1",
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"Abstract"
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0,
8
]
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"db_id": "C0000857"
}
]
},
{
"id": "DerHautarzt.40450630.eng.abstr-s2-t1",
"type": "umlsterm",
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"ultrasound"
],
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119,
129
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"db_id": "C0220934"
},
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},
{
"db_name": "UMLS",
"db_id": "C0041621"
}
]
},
{
"id": "DerHautarzt.40450630.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"venous insufficiency"
],
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57,
77
]
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"db_id": "C0042485"
}
]
},
{
"id": "DerHautarzt.40450630.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"chronic venous insufficiency"
],
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49,
77
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],
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"db_id": "C0042485"
}
]
},
{
"id": "DerHautarzt.40450630.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"skin"
],
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[
149,
153
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.40450630.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"biopsies"
],
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[
154,
162
]
],
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{
"db_name": "UMLS",
"db_id": "C0220797"
},
{
"db_name": "UMLS",
"db_id": "C0005558"
}
]
},
{
"id": "DerHautarzt.40450630.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"light"
],
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190,
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{
"id": "DerHautarzt.40450630.eng.abstr-s3-t4",
"type": "umlsterm",
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"microscopy"
],
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196,
206
]
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"db_id": "C0026018"
}
]
},
{
"id": "DerHautarzt.40450630.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"sclerosis"
],
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[
237,
246
]
],
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{
"db_name": "UMLS",
"db_id": "C0036429"
}
]
},
{
"id": "DerHautarzt.40450630.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"ultrasound"
],
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249,
259
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"db_id": "C0220934"
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{
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"db_id": "C0041618"
},
{
"db_name": "UMLS",
"db_id": "C0041621"
}
]
},
{
"id": "DerHautarzt.40450630.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"dermis"
],
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295,
301
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"db_id": "C0011646"
}
]
},
{
"id": "DerHautarzt.40450630.eng.abstr-s4-t4",
"type": "umlsterm",
"text": [
"fat"
],
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353,
356
]
],
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"db_id": "C0015677"
}
]
},
{
"id": "DerHautarzt.40450630.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"dermis"
],
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414,
420
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],
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]
},
{
"id": "DerHautarzt.40450630.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"capillaries"
],
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462,
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],
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"db_id": "C0006901"
}
]
},
{
"id": "DerHautarzt.40450630.eng.abstr-s5-t3",
"type": "umlsterm",
"text": [
"histology"
],
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[
477,
486
]
],
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"db_id": "C0019638"
},
{
"db_name": "UMLS",
"db_id": "C0205462"
}
]
},
{
"id": "DerHautarzt.40450630.eng.abstr-s6-t1",
"type": "umlsterm",
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"ultrasound"
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525,
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},
{
"db_name": "UMLS",
"db_id": "C0041621"
}
]
},
{
"id": "DerHautarzt.40450630.eng.abstr-s6-t2",
"type": "umlsterm",
"text": [
"objective"
],
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[
565,
574
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018017"
}
]
}
] |
[] |
[] |
[
{
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{
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},
{
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{
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{
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{
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},
{
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{
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},
{
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"type": "measures",
"arg1_id": "DerHautarzt.40450630.eng.abstr-s6-t2",
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},
{
"id": "DerHautarzt.40450630.eng.abstr-s3-r3-t1.1-t3.1",
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},
{
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},
{
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"arg2_id": "DerHautarzt.40450630.eng.abstr-s6-t2",
"normalized": []
},
{
"id": "DerHautarzt.40450630.eng.abstr-s3-r6-t4.1-t1.1",
"type": "measures",
"arg1_id": "DerHautarzt.40450630.eng.abstr-s4-t4",
"arg2_id": "DerHautarzt.40450630.eng.abstr-s6-t1",
"normalized": []
},
{
"id": "DerHautarzt.40450630.eng.abstr-s3-r7-t4.1-t3.1",
"type": "assesses_effect_of",
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},
{
"id": "DerHautarzt.40450630.eng.abstr-s4-r1-t4.1-t2.3",
"type": "affects",
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"arg2_id": "DerHautarzt.40450630.eng.abstr-s4-t2",
"normalized": []
},
{
"id": "DerHautarzt.40450630.eng.abstr-s4-r2-t2.1-t2.3",
"type": "measures",
"arg1_id": "DerHautarzt.40450630.eng.abstr-s6-t2",
"arg2_id": "DerHautarzt.40450630.eng.abstr-s4-t2",
"normalized": []
},
{
"id": "DerHautarzt.40450630.eng.abstr-s4-r3-t4.1-t1.1",
"type": "affects",
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"normalized": []
},
{
"id": "DerHautarzt.40450630.eng.abstr-s4-r4-t3.1-t2.1",
"type": "location_of",
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"arg2_id": "DerHautarzt.40450630.eng.abstr-s6-t2",
"normalized": []
},
{
"id": "DerHautarzt.40450630.eng.abstr-s4-r5-t1.1-t2.3",
"type": "result_of",
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"arg2_id": "DerHautarzt.40450630.eng.abstr-s4-t2",
"normalized": []
},
{
"id": "DerHautarzt.40450630.eng.abstr-s4-r6-t2.1-t1.1",
"type": "associated_with",
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},
{
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},
{
"id": "DerHautarzt.40450630.eng.abstr-s4-r8-t3.1-t1.1",
"type": "location_of",
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"arg2_id": "DerHautarzt.40450630.eng.abstr-s6-t1",
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},
{
"id": "DerHautarzt.40450630.eng.abstr-s4-r9-t1.1-t2.1",
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},
{
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},
{
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},
{
"id": "DerHautarzt.40450630.eng.abstr-s5-r1-t1.1-t2.1",
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},
{
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},
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},
{
"id": "DerHautarzt.40450630.eng.abstr-s5-r5-t2.1-t3.1",
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},
{
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}
] |
DerHautarzt.40450635.eng.abstr
|
DerHautarzt.40450635.eng.abstr
|
[
{
"id": "DerHautarzt.40450635.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . A case simulating extraordinarily extensive chronic vegetating pyoderma revealed itself in its course to be pyoderma gangrenosum . The bacterial flora varied due to a secondary colonization ; there was no response to antibiotics but there was to corticosteroid , azathioprine and clofazimine therapy . IgA-paraproteinemia was found . Pyoderma gangrenosum has historically been considered to be a chronic ulcerous pyoderma and is not a disease of bacterial origin . Reviewing the literature available since the turn of this century , chronic vegetating pyoderma is compared with the latter from the viewpoint of clinical features , histopathology , immunology , course and treatment . There are so many convincing parallels between the two conditions that we would like to propose that we stop regarding them as distinct entities and instead view them as parts of a spectrum of the same immunopathological process ."
],
"offsets": [
[
0,
925
]
]
}
] |
[
{
"id": "DerHautarzt.40450635.eng.abstr-s1-t1",
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"Abstract"
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]
},
{
"id": "DerHautarzt.40450635.eng.abstr-s2-t1",
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"text": [
"pyoderma"
],
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74,
82
]
],
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{
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"db_id": "C0034212"
}
]
},
{
"id": "DerHautarzt.40450635.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"pyoderma"
],
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[
119,
127
]
],
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{
"db_name": "UMLS",
"db_id": "C0034212"
}
]
},
{
"id": "DerHautarzt.40450635.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"pyoderma gangrenosum"
],
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119,
139
]
],
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"db_id": "C0085652"
}
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},
{
"id": "DerHautarzt.40450635.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"bacterial"
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146,
155
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],
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"db_id": "C0521009"
}
]
},
{
"id": "DerHautarzt.40450635.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"secondary"
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178,
187
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"db_id": "C0027627"
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[] |
[] |
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DerHautarzt.40450639.eng.abstr
|
DerHautarzt.40450639.eng.abstr
|
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"text": [
"Abstract . We report on a case of secondary syphilis that became clinically manifest as partially erosive , almost asymptomatic lesions of the oral mucosa . Dark-field microscopy , typical serological parameters and the presence of spirochetes in the biopsy material promptly led to the diagnosis . Depending on the clinical picture , the possibility of syphilis should not be overlooked in the differential diagnosis of disease of the oral mucosa ."
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DerHautarzt.40450642.eng.abstr
|
DerHautarzt.40450642.eng.abstr
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DerHautarzt.40450671.eng.abstr
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DerHautarzt.40450671.eng.abstr
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"Abstract . Chemoprevention , the use of drugs to prevent invasive neoplasia , has gained increasing significance in recent years . Especially for the skin , chemoprevention will become of importance , because large areas of the skin are exposed to environmental carcinogenic factors . Furthermore , many skin diseases predispose to the development of multiple skin tumours . One group of chemopreventive agents are the retinoids , which are effective modulators of cell proliferation and differentiation in normal as well as in transformed tissues . Though the mechanism of action of retinoids is not yet fully understood at the molecular level , chemoprevention studies have demonstrated the ability of retinoids to prevent the development of skin cancer , particularly in patients with xeroderma pigmentosum , multiple basal cell carcinoma and oral leukoplakia . A better understanding of the carcinogenic process should improve our ability to develop effective chemoprevention strategies ."
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DerHautarzt.40450690.eng.abstr
|
DerHautarzt.40450690.eng.abstr
|
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{
"id": "DerHautarzt.40450690.eng.abstr-passage-0",
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"text": [
"Abstract . 34 Patients with subacute cutaneous lupus erythematosus ( SCLE ) were prospectively followed up and examined twice in 1986 - 1989 and 1990 - 1991 , with a minimal interval of 2 years . The findings obtained were documented in a computerized registry and were evaluated by computer-assisted analysis . Thirty-one women and three men aged 23 - 66 years at the time of the first documentation ( FD ) were included in the study . The disease had lasted an average 6.5 years ( from a few months to 39 years ) . Prominent cutaneous manifestations of SCLE were shown by 79.4% of the patients at the first visit compared to 58.8% at the second documentation ( SD ) , whereas the incidence of acrolocalized vasculitis increased ( FD 20.6% , SD 41.2% ) , as did that of Raynaud phenomenon ( FD 20.6% , SD 26.5% ) . Mild extracutaneous symptomatology was found in 70.6% ( FD ) and in 85.3% ( SD ) of the SCLE patients . Arthralgia ( FD 47% , SD 61.8% ) and symptoms suggesting some involvement of the peripheral or central nervous system ( FD 29.4% , SD 50% ) were noted most frequently . Overall , during the follow-up there was a quantitative mild increase of extracutaneous symptomatology ; a significant correlation between the presence of acrolocalized vasculitis and arthralgia was found . In conclusion , the prognosis of SCLE appears rather benign ; fulminant courses were not observed . However , the risk of mild systemic involvement clearly increases during the prospective course of the disease , whereby acrolocalized vasculitis can be regarded as a cutaneous marker for extracutaneous manifestations ."
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[] |
[] |
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DerHautarzt.40450696.eng.abstr
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DerHautarzt.40450696.eng.abstr
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"Abstract . Reflex sympathetic dystrophy is characterized clinically by the triad of autonomic sympathetic dysfunction , and motor and sensory disturbances of the affected extremity . Typical symptoms are distal generalized edema with cyanotic skin , pathologic function of eccrine sweat glands and diffuse dull pain . If reflex sympathetic dystrophy is not recognized an irreversible stage may be reached , with atrophic pale , cool , and anhidrotic skin , contractures and diffuse osteoporosis . The syndrome can be idiopathic but can also be precipitated by a variety of factors , including banal trauma , bone fracture , and traumatic nerve lesions . Pathophysiologically , a functional disturbance of sympathetic nerve fibres may result in a vicious circle of blood flow dysfunction , excitation of afferent nociceptors and maintenance of sympathetic dysfunction at the level of the spinal or central nervous system . In the patient presented in this paper , sympathetic dysregulation of reflex sympathetic dystrophy was cured by means of blockades of the stellate ganglion ."
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] |
DerHautarzt.40450702.eng.abstr
|
DerHautarzt.40450702.eng.abstr
|
[
{
"id": "DerHautarzt.40450702.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . During a period of 3 years , four controled clinical studies in 34 patients with hypercholesterolaemia and 40 healthy persons - in some cases with stratification of the basic cholesterol levels and matched pair formation - were performed to find out the effects of serial sun-like UV irradiation on various serum parameters and blood circulation functions . The following significant effects were observed . Patients with hypercholesterolaemia : increase of HDL cholesterol after termination of the serial UV irradiation , increase of serum 25 ( OH ) D3 levels , decrease of serum triiodothyronine , decrease of serum lactate ; healthy persons : decrease of resting pulse rate , decrease of recovery pulse rate , decrease of systolic blood pressure . All effects were induced by application of suberythematous UV doses , i.e. amounts of UV with a relatively low risk of side effects ."
],
"offsets": [
[
0,
895
]
]
}
] |
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] |
[] |
[] |
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DerHautarzt.40450708.eng.abstr
|
DerHautarzt.40450708.eng.abstr
|
[
{
"id": "DerHautarzt.40450708.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . A patient suffering from long-standing pustular psoriasis of the palms was treated for 3 weeks with a mercury-containing drug . Exacerbation into generalized pustular psoriasis developed . Mercury levels in blood and urine were increased . After withdrawal of the mercury preparation , therapy with DMPA ( 2,3-Dimercapto-1-propane-sulfonic acid ) , a mercury antidote , was initiated , together with short-term treatment with aromatic retinoids and PUVA . Within a few days mercury levels decreased significantly and the skin lesions practically disappeared ."
],
"offsets": [
[
0,
570
]
]
}
] |
[
{
"id": "DerHautarzt.40450708.eng.abstr-s1-t1",
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"Abstract"
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8
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{
"id": "DerHautarzt.40450708.eng.abstr-s2-t1",
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"patient"
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13,
20
]
],
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"db_id": "C0030705"
}
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},
{
"id": "DerHautarzt.40450708.eng.abstr-s2-t2",
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"psoriasis"
],
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[
59,
68
]
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"db_id": "C0033860"
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{
"id": "DerHautarzt.40450708.eng.abstr-s2-t3",
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"drug"
],
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[
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"id": "DerHautarzt.40450708.eng.abstr-s3-t1",
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[] |
[] |
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DerHautarzt.40450711.eng.abstr
|
DerHautarzt.40450711.eng.abstr
|
[
{
"id": "DerHautarzt.40450711.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . Adult-onset Still's disease ( AOSD ) is a rare syndrome of unknown origin consisting of recurrent fever , urticarial rash , arthralgias or arthritides , lymphadenopathia , splenomegalia and nonspecific sore throat . It is always linked with leucocytosis and negative blood cultures ; rheumatic and antinuclear factors are mostly negative . Very high ferritin levels are frequent and could be a marker of the disease . We report on two cases and give a review of the literature ."
],
"offsets": [
[
0,
489
]
]
}
] |
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DerHautarzt.40450716.eng.abstr
|
DerHautarzt.40450716.eng.abstr
|
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{
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"text": [
"Abstract . Pacemaker erythema is a rare , irreversible side effect of cardiac pacemakers , clinically characterized by epifocal teleangiectatic erythema . Histology reveals teleangiectatic vessels in the superficial dermis and a slight perivascular infiltrate . We report on three patients presenting with pacemaker erythema following either pacemaker or defibrillator implantation . The pathogenesis of this histopathologically uncharacteristic lesion is unknown . In contrast to peri- or postoperative pacemaker infections , physical irritation can be considered a possible triggering mechanism . Allergic reactions to the implanted material have been ruled out by negative patch test results ."
],
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]
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[] |
[] |
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] |
DerHautarzt.40450719.eng.abstr
|
DerHautarzt.40450719.eng.abstr
|
[
{
"id": "DerHautarzt.40450719.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . We report on the case of a 70-year-old caucasian woman with a large linear sebaceous naevus with multifocal intralesional basaliomas and a lipodermoid of the left eye . This rare finding has been preserved because of the special history of the patient . The naevus spread on the left side from parietal to retroauricular , nuchal and sternal . Because of the patient's cardio-pulmonary insufficiency we excised the basaliomas under local anaesthesia . We also made a partial stripped excision of the left-sided parietal parts of the naevus ."
],
"offsets": [
[
0,
552
]
]
}
] |
[
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{
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"caucasian"
],
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]
],
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"db_id": "C0043157"
}
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},
{
"id": "DerHautarzt.40450719.eng.abstr-s2-t2",
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"text": [
"woman"
],
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60,
65
]
],
"normalized": [
{
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"db_id": "C0043210"
}
]
},
{
"id": "DerHautarzt.40450719.eng.abstr-s2-t3",
"type": "umlsterm",
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"naevus"
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[
96,
102
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],
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},
{
"id": "DerHautarzt.40450719.eng.abstr-s2-t4",
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"text": [
"eye"
],
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[
174,
177
]
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{
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"db_id": "C0015392"
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{
"db_name": "UMLS",
"db_id": "C0023924"
}
]
},
{
"id": "DerHautarzt.40450719.eng.abstr-s3-t1",
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"finding"
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[
190,
197
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"id": "DerHautarzt.40450719.eng.abstr-s3-t2",
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},
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"id": "DerHautarzt.40450719.eng.abstr-s3-t3",
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255,
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{
"id": "DerHautarzt.40450719.eng.abstr-s4-t1",
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"naevus"
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269,
275
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},
{
"id": "DerHautarzt.40450719.eng.abstr-s5-t1",
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"local anaesthesia"
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"id": "DerHautarzt.40450719.eng.abstr-s6-t1",
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544,
550
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"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027960"
}
]
}
] |
[] |
[] |
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DerHautarzt.40450722.eng.abstr
|
DerHautarzt.40450722.eng.abstr
|
[
{
"id": "DerHautarzt.40450722.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . We report on a rare case of a solitary subcutaneous metastasis from a chondrosarcoma . The metastasis occurred 7 years after excision of the primary neoplasm . Further investigations revealed no evidence of other metastases . Nevertheless , according to data in the literature , the prognosis has to be considered very poor ."
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[] |
[] |
[] |
DerHautarzt.40450741.eng.abstr
|
DerHautarzt.40450741.eng.abstr
|
[
{
"id": "DerHautarzt.40450741.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . The product of the p53 tumour suppressor gene is a sequence-specific DNA-binding protein that acts as a transcription factor and can inhibit transformation in vitro . Mutational inactivation of p53 is the most frequent genetic alteration found in human cancer . Point mutations of the p53 gene have been detected in about 50% of squamous cell carcinomas , basaliomas and cases of Bowen's disease . A significant portion of these mutations were CC- > TT or C- > T transitions suggestive of UV involvement in mutagenesis . Increased concentrations of p53 protein were immunohistochemically detected in cutaneous malignant melanomas , but p53 mutations are rare in this tumour ."
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] |
[] |
[] |
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DerHautarzt.40450756.eng.abstr
|
DerHautarzt.40450756.eng.abstr
|
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{
"id": "DerHautarzt.40450756.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . Tap water iontophoresis is the therapy of choice in hyperhidrosis palmoplantaris . Therapeutic regimens , however , vary greatly . The aim of the present study was to develop an optimized therapeutic scheme . The main methodologic parameters subjected to systematic experimental study included the effects of current polarity , the duration of a single treatment session , the addition of electrolytes to the tap water and the treatment interval during maintenance therapy . The following procedure is proposed . During the initial phase , treatments are carried out three times weekly for 10 min each time . The anode is kept on one extremity until normhidrosis is reached on this extremity . Then , polarity is changed until sweating is reduced to normal on the other extremity ( constant polarity ) . In the subsequent maintenance phase , patients are treated at intervals of 6 - 8 days for 10 min each time . Polarity is switched from treatment to treatment ( alternating polarity ) . Plain tap water is used without additives ."
],
"offsets": [
[
0,
1043
]
]
}
] |
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DerHautarzt.40450762.eng.abstr
|
DerHautarzt.40450762.eng.abstr
|
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"Abstract . Nucleolus-organizing regions ( AgNORs ) are silver-stained loops of DNA transcribing to ribosomal RNA . Quantitative analysis helps to differentiate normal tissue from malignant tissue and can be used for diagnosis in several kinds of tumours . The analysis of AgNORs can also be used in dermatopathology for diagnostic and prognostic purposes . Apart from skin tumours such as basal cell carcinomas and squamous cell carcinomas , this technique is of interest principally for melanocytic lesions . Benign naevi can be distinguished from malignant melanomas by simple counting of the AgNOR dots . For the differentiation of dysplastic naevi , Spitz naevi and malignant melanomas , this parameter alone is not sufficient . By combination of several AgNOR parameters ( number , size , pattern of dispersal ) only , significant differentiation could be achieved . The prognostic value of AgNORs remains to be examined ."
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[] |
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DerHautarzt.40450769.eng.abstr
|
DerHautarzt.40450769.eng.abstr
|
[
{
"id": "DerHautarzt.40450769.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . Initial examination of an andrological patient revealed high-grade oligoasthenoteratozoospermia and ureaplasma infection . An elevated FSH level and significantly reduced testicular size were indicative of severely damaged testicular parenchyma . The presence of macrophages in the sperm smear was interpreted as a sign of chronic epididymitis . Antibiotic couple therapy with doxycycline , followed by a 3-month recovery period with combined treatment with vitamin C and E and zinc , resulted in a significantly improved spermiogram . After another 2 months intrauterine insemination resulted in pregnancy , and the birth of a healthy daughter followed . Preparation of the ejaculate was done by glasswool filtration . At that time , the patient had only mild teratozoospermia ."
],
"offsets": [
[
0,
790
]
]
}
] |
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"ureaplasma"
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111,
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],
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DerHautarzt.40450772.eng.abstr
|
DerHautarzt.40450772.eng.abstr
|
[
{
"id": "DerHautarzt.40450772.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . We report on a 41-year-old patient who developed extensive chronic sclerodermatous graft-versus-host disease ( GvHD ) subsequent to an allogeneic bone marrow transplantation from his HLA-identical sister . Chronic GvHD is to be expected in 30% of bone marrow transplantations . It is a serious multisystem disorder which leads to a polymorphic clinical picture with lichenoid or sclerodermatous skin changes . It may also affect nails , hair and mucous membranes . In the absence of causal therapy GvHD should be managed with symptomatic local treatment and systemic immunosuppression ."
],
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0,
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]
}
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[] |
[] |
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}
] |
DerHautarzt.40450776.eng.abstr
|
DerHautarzt.40450776.eng.abstr
|
[
{
"id": "DerHautarzt.40450776.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . Erythrokeratolysis hiemalis , keratolytic winter erythema or Oudtshoorn skin has been reported from the South African district of Oudtshoorn as a dominantly inherited dermatosis beginning in early childhood , in some cases with circinar scaling erythemas . Seasonal manifestation in winter-time and a characteristic multiform histology distinguish this dermatosis from other childhood scaling erythemas . We present clinical , histological and preliminary immunohistological data of a 4-year-old girl with the attributes of erythrokeratolysis hiemalis . No ancestors from the endemic region were traced . The lack of further cases in the family is interpreted as indicative of a spontaneous dominant new mutation ."
],
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[
0,
725
]
]
}
] |
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"keratolytic"
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41,
52
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],
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"db_id": "C0022585"
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},
{
"id": "DerHautarzt.40450776.eng.abstr-s2-t2",
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"erythema"
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60,
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]
},
{
"id": "DerHautarzt.40450776.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"skin"
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83,
87
]
],
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{
"id": "DerHautarzt.40450776.eng.abstr-s2-t4",
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]
},
{
"id": "DerHautarzt.40450776.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"histology"
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},
{
"id": "DerHautarzt.40450776.eng.abstr-s3-t2",
"type": "umlsterm",
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364,
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},
{
"id": "DerHautarzt.40450776.eng.abstr-s3-t3",
"type": "umlsterm",
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"erythemas"
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404,
413
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],
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"db_id": "C0041834"
}
]
},
{
"id": "DerHautarzt.40450776.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"endemic"
],
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[
587,
594
]
],
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{
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"db_id": "C0243130"
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},
{
"id": "DerHautarzt.40450776.eng.abstr-s6-t1",
"type": "umlsterm",
"text": [
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]
},
{
"id": "DerHautarzt.40450776.eng.abstr-s6-t2",
"type": "umlsterm",
"text": [
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715,
723
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0026882"
}
]
}
] |
[] |
[] |
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{
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{
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},
{
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},
{
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{
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{
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{
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},
{
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},
{
"id": "DerHautarzt.40450776.eng.abstr-s2-r17-t1.1-t2.1",
"type": "diagnoses",
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},
{
"id": "DerHautarzt.40450776.eng.abstr-s2-r18-t3.1-t2.1",
"type": "associated_with",
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},
{
"id": "DerHautarzt.40450776.eng.abstr-s2-r19-t3.1-t5.1",
"type": "location_of",
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},
{
"id": "DerHautarzt.40450776.eng.abstr-s2-r20-t5.1-t3.1",
"type": "evaluation_of",
"arg1_id": "DerHautarzt.40450776.eng.abstr-s2-t5",
"arg2_id": "DerHautarzt.40450776.eng.abstr-s3-t3",
"normalized": []
},
{
"id": "DerHautarzt.40450776.eng.abstr-s2-r21-t5.1-t4.1",
"type": "degree_of",
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},
{
"id": "DerHautarzt.40450776.eng.abstr-s2-r22-t1.1-t5.1",
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},
{
"id": "DerHautarzt.40450776.eng.abstr-s2-r23-t4.1-t5.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.40450776.eng.abstr-s2-t4",
"arg2_id": "DerHautarzt.40450776.eng.abstr-s2-t5",
"normalized": []
},
{
"id": "DerHautarzt.40450776.eng.abstr-s2-r24-t1.1-t3.1",
"type": "disrupts",
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"arg2_id": "DerHautarzt.40450776.eng.abstr-s3-t3",
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},
{
"id": "DerHautarzt.40450776.eng.abstr-s2-r25-t3.1-t4.1",
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},
{
"id": "DerHautarzt.40450776.eng.abstr-s2-r26-t2.1-t3.1",
"type": "evaluation_of",
"arg1_id": "DerHautarzt.40450776.eng.abstr-s6-t2",
"arg2_id": "DerHautarzt.40450776.eng.abstr-s3-t3",
"normalized": []
},
{
"id": "DerHautarzt.40450776.eng.abstr-s2-r27-t4.1-t3.1",
"type": "associated_with",
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"arg2_id": "DerHautarzt.40450776.eng.abstr-s3-t3",
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},
{
"id": "DerHautarzt.40450776.eng.abstr-s3-r1-t3.1-t1.1",
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},
{
"id": "DerHautarzt.40450776.eng.abstr-s3-r2-t1.2-t3.1",
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},
{
"id": "DerHautarzt.40450776.eng.abstr-s3-r3-t1.2-t3.1",
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},
{
"id": "DerHautarzt.40450776.eng.abstr-s3-r4-t3.1-t1.2",
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},
{
"id": "DerHautarzt.40450776.eng.abstr-s3-r5-t3.1-t1.2",
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},
{
"id": "DerHautarzt.40450776.eng.abstr-s3-r6-t1.2-t1.1",
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"arg2_id": "DerHautarzt.40450776.eng.abstr-s6-t1",
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},
{
"id": "DerHautarzt.40450776.eng.abstr-s6-r1-t2.1-t1.1",
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"arg2_id": "DerHautarzt.40450776.eng.abstr-s6-t1",
"normalized": []
}
] |
DerHautarzt.40450780.eng.abstr
|
DerHautarzt.40450780.eng.abstr
|
[
{
"id": "DerHautarzt.40450780.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A case of locally extensive perigenital Paget's disease in an 84-year-old man is presented . Topical application of 5-fluorouracil emerged as the safest and most effective treatment because of the patient's poor general condition and the extensive involvement of the pubic and genital skin ."
],
"offsets": [
[
0,
291
]
]
}
] |
[
{
"id": "DerHautarzt.40450780.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"disease"
],
"offsets": [
[
48,
55
]
],
"normalized": [
{
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"db_id": "C0012634"
}
]
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[] |
[] |
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DerHautarzt.40450783.eng.abstr
|
DerHautarzt.40450783.eng.abstr
|
[
{
"id": "DerHautarzt.40450783.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . A 19-year-old male patient with chronic cutaneous leishmaniosis was treated topically with paromomycin sulphate ( 15% ) and methylbenzethonium chloride ( 12% ) in petrolatum album . After application twice daily for two periods of 32 and 44 days the lesions were completely healed . Previous treatment for 9 months with ketoconazole ( 400 mg/day ) together with the topical application of thiabendazole ( 2.5% ) in base had been unsuccessful . No major side effects were observed after paromomycin sulphate application ."
],
"offsets": [
[
0,
531
]
]
}
] |
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"id": "DerHautarzt.40450783.eng.abstr-s2-t9",
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"id": "DerHautarzt.40450783.eng.abstr-s2-t10",
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] |
[] |
[] |
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DerHautarzt.40450787.eng.abstr
|
DerHautarzt.40450787.eng.abstr
|
[
{
"id": "DerHautarzt.40450787.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . Progressive systemic sclerosis ( PSS ) is characterized in most patients by initially unspecific symptoms like acrocyanosis , Raynaud's phenomenon , general malaise or acral paresthesia . Clinical manifestations appear with an edematous-inflammatory stage of disease leading to a chronic-progressive phase with increasing fibrosclerosis of the skin and internal organs . Dermal involvement and the demonstration of immunopathological abnormalities in the peripheral blood precede visceral fibrosis in most cases . We report on an unusual case of diffuse PSS with preceding involvement of internal organs . Early visceral fibrosis is demonstrated by histomorphological results and is correlated with laboratory findings . Serum antinuclear antibodies could not be obtained until 4 months ante finem and the liver was also involved in the fibrotic process ."
],
"offsets": [
[
0,
866
]
]
}
] |
[
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{
"id": "DerHautarzt.40450787.eng.abstr-s2-t1",
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],
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32,
41
]
],
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{
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"PSS"
],
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44,
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]
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"id": "DerHautarzt.40450787.eng.abstr-s2-t3",
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DerHautarzt.40450799.eng.abstr
|
DerHautarzt.40450799.eng.abstr
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"Abstract . The tophus is a characteristic and pathognomonic sign of chronic gout . Before effective drugs were available for the treatment of hyperuricaemia about 50 - 60% of patients with gout developed clinically and radiologically apparent urate crystal deposits . Clinical cutaneous manifestations of chronic gout are now rarely observed . However , the presence of degenerative tissues , as in idiopathic osteoarthritis of the fingers , may predispose to the deposition of urate crystals . We report on a patient with secondary - probably diuretic-induced - hyperuricaemia and gout tophi in Heberden's nodes ."
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[] |
[] |
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{
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DerHautarzt.40450834.eng.abstr
|
DerHautarzt.40450834.eng.abstr
|
[
{
"id": "DerHautarzt.40450834.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . Based on reports in the literature , data from the information network of German dermatology centres ( Informationsverbund Dermatologischer Kliniken ) and the authors own findings , a review is presented on prevalence , clinical picture and causative agents of contact allergic dermatoses , in health care professions . In 1991 the proportion of suspected occupational diseases in the health care professions ( including hairdressers ) represented by cases of dermatitis , as reported to the responsible insurance institution , reached 72% of the total for the year ( 7287 out of 10 127 ) . Every 20th to 40th case was recognized as an occupational dermatosis according to German law . Accurate figures on incidence are scarce ; for dentists an incidence of 0.11permil has been calculated . The risk of developing occupational hand eczema has been shown to be at least three times higher for nurses than for other so-called dry professions . For persons engaged in the personal care of the ill and the elderly , relevant occupational allergens were found to be benzalkonium chloride and aldehydes in disinfectants , as well as rubber accelerators such as thiuram mix . Latex contact urticaria has increasing significance for medical personnel , with prevalence rates of sensitization between 4.5% and 10.7% . Among physicians , contact allergies to thiuram mix were found to be dominant ( 12.9% ) . For surgeons and orthopaedic surgeons , methyl metacrylate as a constituent of bone cement is of great importance . Various esters of acrylic acid and methacrylic acid are important sensitizers in the dental professions , particularly in heavily exposed dental laboratory technicians . Only a few gloves protect against these types of sensitizers . Sensitizations by medicaments can be avoided in most cases by reducing direct skin contact , as practiced with penicillin or ispaghula powder . Strategies of prevention include information of atopics regarding the increase in occupational dermatitis , the regular use of barrier creams , intensive skin care after work and avoidance of irritants and allergens wherever possible ."
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]
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}
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DerHautarzt.40450845.eng.abstr
|
DerHautarzt.40450845.eng.abstr
|
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{
"id": "DerHautarzt.40450845.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . Taking into account the increase in worldwide human migration , leprosy is of growing importance in the differential diagnosis of dermatological diseases encountered in Central Europe . We report on the case of a young man from Ghana who developed hypopigmented maculae and plaques on his trunk and proximal limbs . The diagnosis of lepromatous leprosy could be made in consideration of the histological pattern of infiltrating leucocytes and detection of numerous acid-fast mycobacteria on skin biopsy . The results of the physical examination as well as routine laboratory and immunological parameters were consistent with this form of leprosy . Due to glucose-6-phosphate-dehydrogenase deficiency , treatment with dapsone was contraindicated . With high-dose rifampicin and clofazimine therapy , the skin changes cleared over the course of 11 months following a leprosy reaction type II ( erythema nodosum leprosum ) that developed during a phase of discontinued therapy due to low patient compliance ."
],
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[
0,
1016
]
]
}
] |
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"id": "DerHautarzt.40450845.eng.abstr-s4-t3",
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DerHautarzt.40450849.eng.abstr
|
DerHautarzt.40450849.eng.abstr
|
[
{
"id": "DerHautarzt.40450849.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . The effectiveness of salt water baths and subsequent selective ultraviolet phototherapy ( SUP ) was investigated in a prospective study on 40 patients with psoriasis vulgaris and atopic dermatitis . There were two groups with 20 patients each . The first group was treated with salt water ( 15% ) that contained synthetic Cead Seas salt called \" Psorisal \" ; the patients in the second group had a bath in a 3% NaCl solution . After 4 weeks of daily treatment , we found that 80% of the patients in the group treated with \" Psorisal \" had significantly better results than the second group . The subjective feeling of being ill had decreased significantly in both groups by the end of the study . The only side effect we found was the occurrence of sunburn in few cases , but this occurred significantly less in the \" Psorisal \" group . Both groups generally accepted the balneophototherapy , so it can easily be employed on an outpatient basis ."
],
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[
0,
957
]
]
}
] |
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[] |
[] |
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DerHautarzt.40450854.eng.abstr
|
DerHautarzt.40450854.eng.abstr
|
[
{
"id": "DerHautarzt.40450854.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . In the last few years high-dose intravenous therapy with gammaglobulin in juvenile dermatomyositis with steroid resistant myopathy has been discussed as an alternative to cytostatic therapy . The 12-year-old Filipinogirl suffered from dermatomyositis with pronounced weakness of the limbs and masticatory muscles ; creatinine-kinase was increased 22-fold . After 5 weeks of therapy with prednisolone ( 1.5 mg/kg body weight/daily ) , the creatinine kinase decreased to sixfold of its standard value ; the muscular weakness , however , progressed to almost complete paralysis of the scapular abductors and rotators and the coxofemoral flectors and rotators . Additional therapy with gammaglobulin at a dose of 1 g/kg body weight on two consecutive days at 4-week intervals led to complete restoration of muscular strength , normalization of muscle enzymes , and stabilization of these results after 12 courses of gammaglobulin and discontinuation of the steroid medication after 8 courses . This observation suggests that high-dose intravenous application of gammaglobulin represents an efficient therapy with minimal side effects in steroid-resistant juvenile dermatomyositis ."
],
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[
0,
1188
]
]
}
] |
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DerHautarzt.40450858.eng.abstr
|
DerHautarzt.40450858.eng.abstr
|
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{
"id": "DerHautarzt.40450858.eng.abstr-passage-0",
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"text": [
"Abstract . A 73-year-old women developed an inflammatory tumor on her right cheek within 3 weeks . The lesion measured more than 7 cm in diameter , contained a central crateriform depression and was studded with several sterile pustules . Histology showed a dense dermal infiltration of neutrophils , but no leukocytoclasia or destruction of dermal tissue . There was no associated leukocytosis or fever , but the patient suffered from recurrent chronic bronchitis . Because the acute inflammation was progressive under treatment with antibiotics , high-dose corticosteroids were given systemically . The tumor regressed quickly and resolved without scarring . Although this localized Sweet's syndrome is unusual , it fulfills several major and minor criteria of Sweet's syndrome and thus represents a rare form of this disease ."
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}
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[] |
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DerHautarzt.40450861.eng.abstr
|
DerHautarzt.40450861.eng.abstr
|
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{
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"Abstract . The term \" granulomatous slack skin \" ( GSS ) was introduced by Ackermann for a disease first described by Convit et al. in 1973. GSS represents a rare cutaneous lymphoma characterized by localized elastolytic lesions with a granulomatous infiltrate . We recently observed two male patients with the characteristic features of this disease . Both patients responded well to therapy with interferon-2b. In one patient clinical remission was stable under long-term treatment with clofazimine . We report on common features of these two patients and give a review of the cases published in the literature ."
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614
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}
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[] |
[] |
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DerHautarzt.40450866.eng.abstr
|
DerHautarzt.40450866.eng.abstr
|
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"Abstract . We report on a patient with marked clubbing of the fingers and toes with watch-glass deformity of the nails , diagnosed as idiopathic clubbing . New findings on the pathogenesis of clubbing provide evidence for the important role of cytokines , especially platelet-derived growth factor and tumor necrosis factor-alpha . The differential diagnosis includes , besides rare primary forms , clubbing in malignant neoplasias and chronic inflammatory diseases of the heart , the lung , the upper gastrointestinal tract and the liver . Clubbing can precede other symptoms of neoplasias by months and could be dependent on a genetic predisposition ."
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[] |
[] |
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DerHautarzt.40450875.eng.abstr
|
DerHautarzt.40450875.eng.abstr
|
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[] |
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] |
DerHautarzt.40450882.eng.abstr
|
DerHautarzt.40450882.eng.abstr
|
[
{
"id": "DerHautarzt.40450882.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . An accurate and complete depiction of the halo naevus has been left by Matthias Gruenewald in his painting \" The Temptation of St. Anthony \" , which is part of the Isenheim altar piece ( 1512 - 1516 ) , which is now exhibited in Colmar , Alsace . In contrast , Sutton in 1916 only described a \" leucoderma acquisitum centrifugum \" , leaving the nature of the central lesion in the dark . The term Sutton naevus therefore appears less appropriate than the alternative eponymic designation \" Gruenewald naevus \" ."
],
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0,
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"id": "DerHautarzt.40450882.eng.abstr-s2-t2",
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"painting"
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"id": "DerHautarzt.40450882.eng.abstr-s2-t3",
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"halo naevus"
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"contrast"
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] |
[] |
[] |
[
{
"id": "DerHautarzt.40450882.eng.abstr-s2-r1-t2.1-t1.1",
"type": "causes",
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{
"id": "DerHautarzt.40450882.eng.abstr-s2-r2-t2.1-t3.1",
"type": "causes",
"arg1_id": "DerHautarzt.40450882.eng.abstr-s4-t2",
"arg2_id": "DerHautarzt.40450882.eng.abstr-s2-t3",
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] |
DerHautarzt.50460010.eng.abstr
|
DerHautarzt.50460010.eng.abstr
|
[
{
"id": "DerHautarzt.50460010.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . Five men ( average age 35 years ) suffering from the sequelae of hair implants were examined in the course of claims for legal compensation . Polyether amide hair fibres had been implanted , 1000 per patient and session . In all cases the improved implantation technique with a needle and subcutaneous knotting had been used in a total of three institutions . Three patients developed bacterial folliculitis after 4 - 8 weeks ; in the other two patients this developed later , after 3 - 6 months . In two patients the possible triggering event was the wearing of a motorcycle helmet and a vacation in a tropical climate respectively . In another patient the artificial hair curled considerably after he visited a sauna . The implanted hair had fallen out almost completely in all cases ( 100% in two patients after 9 - 12 months , 50 - 75% in three patients after 7 months to 2 years ) . All patients showed cosmetically disturbing small scars and pigmentary changes . Despite an apparently improved complication rate , the new technique of hair fibre implantation remains a doubtful procedure and cannot be recommended in view of possible permanent sequelae ."
],
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0,
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"id": "DerHautarzt.50460010.eng.abstr-s2-t2",
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"id": "DerHautarzt.50460010.eng.abstr-s2-t5",
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"id": "DerHautarzt.50460010.eng.abstr-s3-t1",
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"id": "DerHautarzt.50460010.eng.abstr-s3-t2",
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"amide"
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"id": "DerHautarzt.50460010.eng.abstr-s3-t3",
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"id": "DerHautarzt.50460010.eng.abstr-s4-t3",
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{
"id": "DerHautarzt.50460010.eng.abstr-s5-t2",
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"id": "DerHautarzt.50460010.eng.abstr-s5-t3",
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},
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"id": "DerHautarzt.50460010.eng.abstr-s6-t2",
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{
"id": "DerHautarzt.50460010.eng.abstr-s6-t3",
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"text": [
"helmet"
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587,
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"id": "DerHautarzt.50460010.eng.abstr-s6-t4",
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},
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"id": "DerHautarzt.50460010.eng.abstr-s6-t5",
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"id": "DerHautarzt.50460010.eng.abstr-s7-t2",
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},
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"id": "DerHautarzt.50460010.eng.abstr-s7-t3",
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"id": "DerHautarzt.50460010.eng.abstr-s9-t3",
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"id": "DerHautarzt.50460010.eng.abstr-s10-t3",
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] |
[] |
[] |
[
{
"id": "DerHautarzt.50460010.eng.abstr-s2-r1-t1.1-t1.2",
"type": "interacts_with",
"arg1_id": "DerHautarzt.50460010.eng.abstr-s10-t1",
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},
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},
{
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},
{
"id": "DerHautarzt.50460010.eng.abstr-s2-r6-t5.1-t2.2",
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DerHautarzt.50460015.eng.abstr
|
DerHautarzt.50460015.eng.abstr
|
[
{
"id": "DerHautarzt.50460015.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . The prevalence of type I allergy against latex was investigated in dental students by questionnaire , prick tests and the determination of specific IgE antibodies . Positive prick tests against different latex fluids were found in 18 ( 8.7% ) of 206 students , with clinical relevance in 11 cases . When the total number of students in each semester was taken into account an increase in the minimal prevalence of clinically relevant latex allergy from 2% in the second semester to 10.4% in the tenth semester was seen . A history of glove intolerance presenting as a wheal-and-flare reaction was associated with a type I allergy against latex in only 50% of the affected subjects . Atopic diseases and hand eczema of different causes proved to be risk factors in 16 and 5 of 18 students with latex allergy , respectively . A high-ammonia accelerator-free latex fluid proved to be a very reliable test medium compared to the less sensitive determination of specific IgE antibodies to latex ."
],
"offsets": [
[
0,
1002
]
]
}
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] |
DerHautarzt.50460022.eng.abstr
|
DerHautarzt.50460022.eng.abstr
|
[
{
"id": "DerHautarzt.50460022.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . In atopic eczema patients the well-known abnormal cutaneous reactivity of the blood vessels ( white dermographism , delayed blanch after acetylcholine , paradoxical blanching after nicotinic acid application and diminished erythema after histamine injection ) were observed during acute eczematous episodes and later in an eczema-free state in comparison with controls . In this follow-up study the use of different stimuli allowed us to demonstrate abnormal cutaneous vascular reactions in the patients depending on the severity of their atopic eczema . Severely affected patients showed persistence of the paradoxical vascular reactions even in an eczema-free cutaneous state ."
],
"offsets": [
[
0,
690
]
]
}
] |
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"eczema"
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]
],
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{
"id": "DerHautarzt.50460022.eng.abstr-s2-t3",
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"blood"
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]
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"id": "DerHautarzt.50460022.eng.abstr-s2-t8",
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"id": "DerHautarzt.50460022.eng.abstr-s2-t12",
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"id": "DerHautarzt.50460022.eng.abstr-s2-t14",
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"id": "DerHautarzt.50460022.eng.abstr-s2-t15",
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DerHautarzt.50460028.eng.abstr
|
DerHautarzt.50460028.eng.abstr
|
[
{
"id": "DerHautarzt.50460028.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . Primary cutaneous large cell anaplastic non-Hodgkin lymphomas positive for Ki-1-antigen are rarely described . There are 100 published cases worldwide . Typically large cell anaplastic lymphomas have an inflammatory appearance , which often leads to false diagnosis and unsuccessful treatment with antibiotics . Histological examination reveals a highly malignant non-Hodgkin lymphoma . The tumour is composed of large pleomorphic lymphoid cells composed of T-cells in 80% of the cases and of B-cells in 10% . The immunological phenotype in the remaining 10% remains unclear . Crucial for the diagnosis is the expression of CD30 antigen in > 70% of the tumour cells . This article presents 5 cases of cutaneous Ki-1-positive lymphoma seen in our Berlin department during the last 10 years . In 4 patients the diagnosis was established in clinical stage I of cutaneous lymphoma without further manifestation ; 1 patient had lymph node involvement and was in stage II . Total excision of the primary tumour in stage I with adjuvant polychemotherapy in stages II - IV led to complete remission in all cases . Long-term remissions were seen in case 1 ( 2 years ) and in case 5 ( 1 year ) , whilst 2 patients showed local relapse , and 1 patient showed generalized lymphogenic and haematogenic metastasis . After repeated surgical removal or irradiation of the tumour and adjuvant polychemotherapy , further complete remission was achieved in 2 patients ( up to now lasting 1 and 4 years ) . Another patient has been in partial remission for the last 2 years . Our observations underline the high relapse rate of large cell anaplastic lymphoma . There was no difference in the incidence of relapse whether the primary tumour was surgically excised or treated with total excision plus adjuvant polychemotherapy . In anaplastic tumours of the skin the diagnosis of Ki-1-lymphoma should be considered ."
],
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0,
1905
]
]
}
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[] |
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DerHautarzt.50460035.eng.abstr
|
DerHautarzt.50460035.eng.abstr
|
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"Abstract . Cutis marmorata teleangiectatica congenita ( CMTC ) is a rare congenital vascular disorder of the venous system . In 50% of cases there are associated anomalies of other organ systems . Clinical improvement of the cutaneous manifestations is noted in most cases and usually occurs during the first year of life . We present a patient with CMTC with a band-like pattern following the L3 dermatome . At the age of 13 years , the skin manifestations worsened , with ulcerations and intermittent claudication . Angiographic imaging revealed stenosis of the deep femoral artery , and the circumflex femoral artery and the first perforating arteries were not visualized . To our knowledge , this is the first reported case of CMTC with anomalies of the large arteries ."
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[] |
[] |
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DerHautarzt.50460039.eng.abstr
|
DerHautarzt.50460039.eng.abstr
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"Abstract . Bacillary angiomatosis ( BA ) is a rare infectious disease usually associated with HIV infection . Recent molecular biologic investigations confirm that both Rochalimaea henselae and Rochalimaea quintana can cause BA . The bacteria can be identified by Warthin-Starry staining and electron microscopy . The typical clinical signs are solitary or multiple dermal or subcutaneous nodules . Bone , liver , spleen and other organs may also be involved . We describe the clinical and histological features of a 39-year-old HIV-infected patient with cutaneous and bony lesions of BA . All manifestations of BA disappeared during therapy with erythromycin ."
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DerHautarzt.50460047.eng.abstr
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DerHautarzt.50460047.eng.abstr
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"Abstract . The so-called amyopathic dermatomyositis is a rare variant of dermatomyositis which has attracted increasing interest during the last years . One finds the classical signs of dermatomyositis such as periorbital edema and erythema , erythematous macular and papular lesions localized at bony prominences ( so-called Gottron's papules ) , generalized pruritus , photosensitivity , and a cutaneous histopathologic picture compatible with skin lesions of dermatomyositis . Crucial for the diagnosis is the exclusion of myositis by clinical examination , EMG and histology . Furthermore , longterm supervision of patients is advisable in order not to miss the appearance of early signs of myositis . The longest reported follow-up of amyopathic dermatomyositis patient is 4 years ; however , it cannot be excluded that these cases will eventually culminate in classical dermatomyositis . In this paper we describe two cases and discuss the differential diagnosis and therapy ; also , the term \" Premyopathic dermatomyositis \" is proposed , to indicate that the full picture is to be expected in most cases ."
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"id": "DerHautarzt.50460047.eng.abstr-s7-r14-t2.2-t1.1",
"type": "uses",
"arg1_id": "DerHautarzt.50460047.eng.abstr-s7-t2",
"arg2_id": "DerHautarzt.50460047.eng.abstr-s7-t1",
"normalized": []
},
{
"id": "DerHautarzt.50460047.eng.abstr-s7-r15-t2.1-t1.1",
"type": "uses",
"arg1_id": "DerHautarzt.50460047.eng.abstr-s7-t2",
"arg2_id": "DerHautarzt.50460047.eng.abstr-s7-t1",
"normalized": []
}
] |
DerHautarzt.50460053.eng.abstr
|
DerHautarzt.50460053.eng.abstr
|
[
{
"id": "DerHautarzt.50460053.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . A 1-year-old girl shows changes of the toenails since birth . There are no associated anomalies typical for genodermatoses , nor is there a family history of this disorder . Physical examination shows missing or incomplete toenails . In addition a shortening of the second toe on both sides and the third toe on the left side is found . The second and third toe on the left side shows incomplete syndactylia . The fingers and fingernails are all normal . Isolated congenital onychodysplasia of the toenails has not been previously reported ."
],
"offsets": [
[
0,
552
]
]
}
] |
[
{
"id": "DerHautarzt.50460053.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"Abstract"
],
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[
0,
8
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0000857"
}
]
},
{
"id": "DerHautarzt.50460053.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"birth"
],
"offsets": [
[
65,
70
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0005615"
}
]
},
{
"id": "DerHautarzt.50460053.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"anomalies"
],
"offsets": [
[
97,
106
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0000769"
}
]
},
{
"id": "DerHautarzt.50460053.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"family"
],
"offsets": [
[
151,
157
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0015576"
}
]
},
{
"id": "DerHautarzt.50460053.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"history"
],
"offsets": [
[
158,
165
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0019664"
},
{
"db_name": "UMLS",
"db_id": "C0019665"
}
]
},
{
"id": "DerHautarzt.50460053.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"disorder"
],
"offsets": [
[
174,
182
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0012634"
}
]
},
{
"id": "DerHautarzt.50460053.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"Physical examination"
],
"offsets": [
[
185,
205
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0031809"
}
]
},
{
"id": "DerHautarzt.50460053.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"toe"
],
"offsets": [
[
284,
287
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0040357"
}
]
},
{
"id": "DerHautarzt.50460053.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"toe"
],
"offsets": [
[
316,
319
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0040357"
}
]
},
{
"id": "DerHautarzt.50460053.eng.abstr-s6-t1",
"type": "umlsterm",
"text": [
"toe"
],
"offsets": [
[
369,
372
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0040357"
}
]
},
{
"id": "DerHautarzt.50460053.eng.abstr-s6-t2",
"type": "umlsterm",
"text": [
"syndactylia"
],
"offsets": [
[
407,
418
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0039075"
}
]
},
{
"id": "DerHautarzt.50460053.eng.abstr-s7-t1",
"type": "umlsterm",
"text": [
"fingers"
],
"offsets": [
[
425,
432
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0016129"
}
]
},
{
"id": "DerHautarzt.50460053.eng.abstr-s8-t1",
"type": "umlsterm",
"text": [
"congenital"
],
"offsets": [
[
475,
485
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0009678"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.50460053.eng.abstr-s3-r1-t1.1-t3.1",
"type": "issue_in",
"arg1_id": "DerHautarzt.50460053.eng.abstr-s8-t1",
"arg2_id": "DerHautarzt.50460053.eng.abstr-s3-t3",
"normalized": []
},
{
"id": "DerHautarzt.50460053.eng.abstr-s3-r2-t1.1-t3.2",
"type": "uses",
"arg1_id": "DerHautarzt.50460053.eng.abstr-s8-t1",
"arg2_id": "DerHautarzt.50460053.eng.abstr-s3-t3",
"normalized": []
},
{
"id": "DerHautarzt.50460053.eng.abstr-s3-r4-t3.2-t1.1",
"type": "occurs_in",
"arg1_id": "DerHautarzt.50460053.eng.abstr-s3-t3",
"arg2_id": "DerHautarzt.50460053.eng.abstr-s8-t1",
"normalized": []
},
{
"id": "DerHautarzt.50460053.eng.abstr-s6-r1-t1.1-t2.1",
"type": "location_of",
"arg1_id": "DerHautarzt.50460053.eng.abstr-s8-t1",
"arg2_id": "DerHautarzt.50460053.eng.abstr-s6-t2",
"normalized": []
}
] |
DerHautarzt.50460076.eng.abstr
|
DerHautarzt.50460076.eng.abstr
|
[
{
"id": "DerHautarzt.50460076.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . Systemically administered lipid-lowering drugs can induce eczema , ichthyosis , or psoriasis as side effects . Common abnormalities in these diseases are a rough , scaly skin , a disturbed permeability barrier and disturbed epidermal proliferation and differentiation . The disturbed epidermal differentiation is accompanied by changes in the keratin composition and the cornified envelope proteins as well as by changes in the lipid composition . Lipid-lowering drugs do not necessarily all cause the same diseases , because they inhibit different steps in the cholesterol synthetic pathway . The lipid-lowering drugs lovastatin ( Mevacor ) , simvastatin ( Zocor ) and pravastatin ( Selipram ) can cause eczema ; these drugs inhibit an early step of cholesterol biosynthesis , viz . HMG-CoA reductase activity . The lipid-lowering drugs triparanol and diazacholesterol inhibit a late step in cholesterol biosynthesis , delta-24-sterol reductase , and they can induce ichthyosis or palmoplantar hyperkeratosis . In contrast , systematically applied gemfibrozil , which mainly lowers triglycerides , can cause an exacerbation of psoriasis . These observations show the importance of the lipid metabolism in the pathogenesis of eczema , ichthyosis , and psoriasis ."
],
"offsets": [
[
0,
1274
]
]
}
] |
[
{
"id": "DerHautarzt.50460076.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"Abstract"
],
"offsets": [
[
0,
8
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0000857"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"lipid-lowering"
],
"offsets": [
[
37,
51
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0023779"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"drugs"
],
"offsets": [
[
52,
57
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0013227"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"eczema"
],
"offsets": [
[
69,
75
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0013595"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"ichthyosis"
],
"offsets": [
[
78,
88
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0020757"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"psoriasis"
],
"offsets": [
[
94,
103
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0033860"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s2-t6",
"type": "umlsterm",
"text": [
"side effects"
],
"offsets": [
[
107,
119
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0001688"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"abnormalities"
],
"offsets": [
[
129,
142
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0000768"
},
{
"db_name": "UMLS",
"db_id": "C0000769"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"diseases"
],
"offsets": [
[
152,
160
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0012634"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"skin"
],
"offsets": [
[
181,
185
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"permeability"
],
"offsets": [
[
200,
212
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0031164"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"keratin"
],
"offsets": [
[
354,
361
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0022564"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"proteins"
],
"offsets": [
[
401,
409
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0033684"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"lipid"
],
"offsets": [
[
439,
444
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0023779"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"Lipid-lowering"
],
"offsets": [
[
459,
473
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0023779"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"drugs"
],
"offsets": [
[
474,
479
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0013227"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s5-t3",
"type": "umlsterm",
"text": [
"diseases"
],
"offsets": [
[
518,
526
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0012634"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s5-t4",
"type": "umlsterm",
"text": [
"cholesterol"
],
"offsets": [
[
573,
584
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0008377"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s6-t1",
"type": "umlsterm",
"text": [
"lipid-lowering"
],
"offsets": [
[
609,
623
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0023779"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s6-t2",
"type": "umlsterm",
"text": [
"drugs"
],
"offsets": [
[
624,
629
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0013227"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s6-t3",
"type": "umlsterm",
"text": [
"lovastatin"
],
"offsets": [
[
630,
640
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0024027"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s6-t4",
"type": "umlsterm",
"text": [
"Mevacor"
],
"offsets": [
[
643,
650
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0728780"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s6-t5",
"type": "umlsterm",
"text": [
"Mevacor"
],
"offsets": [
[
643,
650
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0077971"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s6-t6",
"type": "umlsterm",
"text": [
"simvastatin"
],
"offsets": [
[
655,
666
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0074554"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s6-t7",
"type": "umlsterm",
"text": [
"Zocor"
],
"offsets": [
[
669,
674
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0678181"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s6-t8",
"type": "umlsterm",
"text": [
"pravastatin"
],
"offsets": [
[
681,
692
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0085542"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s6-t9",
"type": "umlsterm",
"text": [
"eczema"
],
"offsets": [
[
716,
722
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0013595"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s6-t10",
"type": "umlsterm",
"text": [
"drugs"
],
"offsets": [
[
731,
736
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0013227"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s6-t11",
"type": "umlsterm",
"text": [
"cholesterol"
],
"offsets": [
[
762,
773
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0008377"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s6-t12",
"type": "umlsterm",
"text": [
"biosynthesis"
],
"offsets": [
[
774,
786
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0005572"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s7-t1",
"type": "umlsterm",
"text": [
"HMG-CoA"
],
"offsets": [
[
795,
802
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0122108"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s7-t2",
"type": "umlsterm",
"text": [
"reductase"
],
"offsets": [
[
803,
812
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030016"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s7-t3",
"type": "umlsterm",
"text": [
"HMG-CoA reductase"
],
"offsets": [
[
795,
812
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0063164"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s8-t1",
"type": "umlsterm",
"text": [
"lipid-lowering"
],
"offsets": [
[
828,
842
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0023779"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s8-t2",
"type": "umlsterm",
"text": [
"drugs"
],
"offsets": [
[
843,
848
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0013227"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s8-t3",
"type": "umlsterm",
"text": [
"triparanol"
],
"offsets": [
[
849,
859
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0041088"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s8-t4",
"type": "umlsterm",
"text": [
"cholesterol"
],
"offsets": [
[
904,
915
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0008377"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s8-t5",
"type": "umlsterm",
"text": [
"biosynthesis"
],
"offsets": [
[
916,
928
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0005572"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s8-t6",
"type": "umlsterm",
"text": [
"reductase"
],
"offsets": [
[
947,
956
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030016"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s8-t7",
"type": "umlsterm",
"text": [
"ichthyosis"
],
"offsets": [
[
979,
989
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0020757"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s8-t8",
"type": "umlsterm",
"text": [
"hyperkeratosis"
],
"offsets": [
[
1006,
1020
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0751995"
}
]
},
{
"id": "DerHautarzt.50460076.eng.abstr-s9-t1",
"type": "umlsterm",
"text": [
"contrast"
],
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] |
DerHautarzt.50460087.eng.abstr
|
DerHautarzt.50460087.eng.abstr
|
[
{
"id": "DerHautarzt.50460087.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . In 77 patients with port-wine stain under 18 years of age we performed 100 test treatments with the flashlamp-pumped pulsed dye laser ( 585 nm , 450 µs, 5 mm beam diameter ) . In 54% of cases we could obtain excellent or good lightening with one test treatment . In only 9% of cases did the patients show bad or no response to laser therapy . In the following treatment of larger areas ( n=125), the rate of good or excellent lightening was even higher ( 60% ) . Side effects were infrequent and consisted mostly of transient hyperpigmentation . In contrast to argon laser therapy , the flashlamp-pumped pulsed dye laser is safe and effective for treatment of port-wine stains in childhood and adolescence . Our results and the good results reported in the literature confirm the flashlamp-pumped pulsed dye laser as the laser of choice for port-wine stain treatment in young patients ."
],
"offsets": [
[
0,
897
]
]
}
] |
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}
] |
[] |
[] |
[
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DerHautarzt.50460094.eng.abstr
|
DerHautarzt.50460094.eng.abstr
|
[
{
"id": "DerHautarzt.50460094.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . In 12 patients with systemic sclerosis the influence of hypnosis and autogenic training on the acral blood circulation and the coping with the disease was investigated in a pilot study . In the first step significant increases in the skin temperature of the fingers ( mean +/- SD : 3.9 +/- 1.2 °C) could be found after relaxation hypnosis . In the second step six patients ( study group ) gained experience with autogenic training . The other six patients served as control group . In the study group , the skin temperature of the fingers ( short-term effect ) was significantly higher than in the control group ( 1.9 +/- 1.0 °C). Long-term effects of the autogenic training ( mean acral rewarning time , duration and course of the Raynaud attacks , acral lesions of the hands , psychosomatic status of complaints , type of relation to the disease as precondition for coping with the disease ) were not found within the relatively short follow-up period of 4 months . Two patients , however , reported that they could shorten the duration of Raynaud attacks by autogenic training . In our patients heterogenicity and an increased score of multiple psychosomatic complaints were registered at the outset . As far as the type of relation to the disease is concerned , the patients could be assessed as almost adapted . Hypnosis and autogenic training can be recommended as complementary therapy in systemic sclerosis ."
],
"offsets": [
[
0,
1427
]
]
}
] |
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{
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"sclerosis"
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"id": "DerHautarzt.50460094.eng.abstr-s2-t7",
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"id": "DerHautarzt.50460094.eng.abstr-s2-t8",
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"id": "DerHautarzt.50460094.eng.abstr-s2-t10",
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]
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"id": "DerHautarzt.50460094.eng.abstr-s3-t2",
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] |
DerHautarzt.50460102.eng.abstr
|
DerHautarzt.50460102.eng.abstr
|
[
{
"id": "DerHautarzt.50460102.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . In 12 patients suffering from systemic sclerosis ( SSc ) the influence of autogenic training on the plasma level of the neuropeptides substance P and vasoactive intestinal peptide ( VIP ) was studied . Compared with healthy controls the SSc patients exhibited significantly elevated levels of substance P ( mean +/- SD : 7.1 +/- 3.2 pmol/l vs 1.6 +/- 1.6 pmol/l ) . Apart from variations the VIP plasma concentration did not significantly differ from that in healthy controls ( mean +/- SD : 10.7 +/- 7.1 pmol/l versus 12.0 +/- 5.3 pmol/l ) . Autogenic training did not bring about any significant changes in the plasma levels of neuropeptides ."
],
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0,
656
]
]
}
] |
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{
"id": "DerHautarzt.50460102.eng.abstr-s2-t2",
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"sclerosis"
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"plasma"
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"id": "DerHautarzt.50460102.eng.abstr-s2-t5",
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"text": [
"neuropeptides"
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131,
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{
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"id": "DerHautarzt.50460102.eng.abstr-s2-t7",
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"text": [
"VIP"
],
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{
"id": "DerHautarzt.50460102.eng.abstr-s2-t8",
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"systemic sclerosis"
],
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41,
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"id": "DerHautarzt.50460102.eng.abstr-s2-t9",
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},
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"id": "DerHautarzt.50460102.eng.abstr-s2-t10",
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"substance P"
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"id": "DerHautarzt.50460102.eng.abstr-s3-t2",
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"patients"
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{
"id": "DerHautarzt.50460102.eng.abstr-s3-t3",
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},
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"id": "DerHautarzt.50460102.eng.abstr-s4-t1",
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"variations"
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},
{
"id": "DerHautarzt.50460102.eng.abstr-s4-t2",
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"concentration"
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[] |
[] |
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] |
DerHautarzt.50460107.eng.abstr
|
DerHautarzt.50460107.eng.abstr
|
[
{
"id": "DerHautarzt.50460107.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report on a 63-year-old female patient with Muir-Torre syndrome ( MTS ) . In the course of this disease two carcinomas of the colon , a kerato-acanthoma and multiple sebaceous gland tumours , including four sebaceous gland tumours , including four sebaceous carcinomas , appeared . This case is thought to be a heriditary form as one of daughters was also found to have a sebaceous epithelioma . MTS is a mostly autosomal-dominant disease with the association of sebaceous gland tumours and internal carcinomas . As the malignant tumours only show slight aggressiveness the prognosis is quite favourable . Oral isotretinoin therapy was successfully used for the inhibition of sebaceous gland proliferation . A narrower definition is presented and an updated survey of the published cases is given . Furthermore , the histopathologic peculiarities of sebaceous gland tumours , especially of sebaceous gland carcinomas , are discussed and compared to sebaceous gland tumours not connected with MTS . A total number of 100 of the 135 published cases of MTS were included and analysed regarding sebaceous gland tumours and other skin tumours . The data on internal carcinomas were taken from the work of Cohen et al. ( 1991 ) and 11 current cases were added ."
],
"offsets": [
[
0,
1258
]
]
}
] |
[
{
"id": "DerHautarzt.50460107.eng.abstr-s1-t1",
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"female"
],
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27,
33
]
],
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"db_name": "UMLS",
"db_id": "C0086287"
},
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"db_id": "C0015780"
}
]
},
{
"id": "DerHautarzt.50460107.eng.abstr-s1-t2",
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"patient"
],
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[
34,
41
]
],
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{
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}
]
},
{
"id": "DerHautarzt.50460107.eng.abstr-s1-t3",
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"text": [
"syndrome"
],
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[
58,
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],
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"db_id": "C0039082"
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{
"id": "DerHautarzt.50460107.eng.abstr-s2-t1",
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"disease"
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]
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{
"id": "DerHautarzt.50460107.eng.abstr-s2-t2",
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"text": [
"carcinomas"
],
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111,
121
]
],
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},
{
"id": "DerHautarzt.50460107.eng.abstr-s2-t3",
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"text": [
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DerHautarzt.50460114.eng.abstr
|
DerHautarzt.50460114.eng.abstr
|
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"id": "DerHautarzt.50460114.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . We report on the case of a 51-year-old female patient who had been suffering from multiple itching nodules for 3 years . Some of these lesions were classified clinically and histologically as keratoacanthomas ( KA ) , whereas the multiple smaller nodules were found on histological examination to be either early stage KA or lesions of prurigo simplex subacuta . In two KA , HPV subtype 2 was identified by in situ hybridization . Treatment with etretinate resulted in remission of the fully developed KA and reduced the occurrence of new ones . The outbreak of multiple KA in our patient resembled a rare subtype described by Witten and Zak . Postclinical follow-up for 28 months to date has revealed that the KA arise from the subacute prurigo lesions . This mode of prurigo-dependent KA development has not previously been reported ."
],
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[
0,
847
]
]
}
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[] |
[] |
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DerHautarzt.50460121.eng.abstr
|
DerHautarzt.50460121.eng.abstr
|
[
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],
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]
}
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[] |
[] |
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DerHautarzt.50460124.eng.abstr
|
DerHautarzt.50460124.eng.abstr
|
[
{
"id": "DerHautarzt.50460124.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . A 51-year-old male patient with histologically confirmed eruptive xanthomatosis is presented . Routine and special laboratory examinations showed complex disturbances of carbohydrate and lipid metabolism , the latter taking the form of classic hyperlipoproteinaemia type IV . Combined oral antilipaemic drugs including acipimox ( methylpyrazine carboxylic acid analogue of nicotinic acid ) and a low-fat diet resulted in regression of the skin symptoms and normalization of the serum lipid levels ."
],
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[
0,
509
]
]
}
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"id": "DerHautarzt.50460124.eng.abstr-s3-t3",
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"id": "DerHautarzt.50460124.eng.abstr-s3-t6",
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"id": "DerHautarzt.50460124.eng.abstr-s4-t2",
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"id": "DerHautarzt.50460124.eng.abstr-s4-t3",
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"id": "DerHautarzt.50460124.eng.abstr-s4-t12",
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[] |
[] |
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DerHautarzt.50460144.eng.abstr
|
DerHautarzt.50460144.eng.abstr
|
[
{
"id": "DerHautarzt.50460144.eng.abstr-passage-0",
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"text": [
"Abstract . To date , the rare primary histiocytoses of the skin are diagnosed definitively on the basis of the clinical symptoms , H&E-stained sections , and demonstration of CD1 positivity in frozen sections and of Birbeck granules on electron microscopy . The improvement and analysis of antibodies with the ability to react in paraffin tissue allow retrospective evaluation and classification of these disorders . The antibodies for S-100-protein, peanut agglutinin ( PNA ) and PCNA ( proliferating cell nuclear antigen ) have been advocated for differentiation of the specific cells of Langerhans cell histiocytosis ( LCH ) from other histiocytic cell systems . To date the non-Langerhans cell histiocytoses ( non-LCH ) have no common ultrastructural and immunohistochemical characteristics . The infiltrate is made up of multiple cell populations , which are of significance for the cellular pathobiology ( subtypes of monocytes/macrophages and dendritic cells ) . The number and distribution of the different monocyte/macrophages and dendritic cells and their ability to react with immunohistochemical markers in paraffin tissue can be completely different in different clinical entities . The antibodies against factor XIIIa ( shown on xanthoma disseminatum ) and the monoclonal antibody Ki-M1P ( shown on juvenile xanthogranuloma ) seem to be valuable in discrimination between LCH and non-LCH . Both markers show a positive staining pattern with the characteristic large macrophages . In juvenile xanthogranuloma , the foam cells and giant cells express Ki-M1P, KP1 and anti-cathepsin B. Other monocyte/macrophage markers with the ability to react in paraffin tissue , such as Mac387 , lysozyme , 1-antitrypsin and Leu-M1 ( Anti-CD 15 ) , in contrast , did not show a typical staining pattern with the characteristic large macrophages dominating the histological picture ."
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] |
[] |
[] |
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DerHautarzt.50460154.eng.abstr
|
DerHautarzt.50460154.eng.abstr
|
[
{
"id": "DerHautarzt.50460154.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . Temporary hair loss is well accepted as a possible result of psoriatic plaques . On the other hand , it is still a controversial issue whether psoriasis can cause scarring alopecia . The following report presents a 38-year-old woman who had been suffering from progressive hair loss from chronic psoriatic plaques of the scalp for some years . Clinical examination revealed an area of scarring alopecia in association with typical features of psoriasis . Histology showed a cordlike fibrosis replacing former hair follicles , a perivascular lymphohistiocytic infiltrate in the upper dermis occasionally invading the follicular epithelium , and characteristic features of psoriasis of the scalp . The clinical course and the lack of evidence for any other causes of scarring alopecia suggest an aetiopathogenetic link between psoriasis and scarring alopecia . Knowledge of this relationship appears to be of practical significance , since efficient antipsoriatic therapy can stop hair loss and thus may be able to prevent scarring ."
],
"offsets": [
[
0,
1042
]
]
}
] |
[
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{
"id": "DerHautarzt.50460154.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"hair"
],
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21,
25
]
],
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"db_id": "C0018494"
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},
{
"id": "DerHautarzt.50460154.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"plaques"
],
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[
82,
89
]
],
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{
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"db_id": "C0011389"
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{
"id": "DerHautarzt.50460154.eng.abstr-s2-t3",
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"text": [
"hair loss"
],
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21,
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{
"id": "DerHautarzt.50460154.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"hand"
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{
"id": "DerHautarzt.50460154.eng.abstr-s3-t2",
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"text": [
"psoriasis"
],
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{
"id": "DerHautarzt.50460154.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"alopecia"
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],
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{
"id": "DerHautarzt.50460154.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"scarring alopecia"
],
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],
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"db_id": "C0086873"
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},
{
"id": "DerHautarzt.50460154.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"woman"
],
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[
238,
243
]
],
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{
"db_name": "UMLS",
"db_id": "C0043210"
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},
{
"id": "DerHautarzt.50460154.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"hair"
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[
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]
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{
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},
{
"id": "DerHautarzt.50460154.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"plaques"
],
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"db_id": "C0011389"
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]
},
{
"id": "DerHautarzt.50460154.eng.abstr-s4-t4",
"type": "umlsterm",
"text": [
"scalp"
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DerHautarzt.50460165.eng.abstr
|
DerHautarzt.50460165.eng.abstr
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"Abstract . In current textbooks of dermatology , lichen amyloidosus is said to be a papular , intensely pruritic type of amyloidosis of unknown aetiology . When this concept was developed , there was no way of discriminating between the different types of amyloid . It is now known that amyloid in lichen amyloidosus is not derived from immunoglobulins or serum proteins , as it is in systemic amyloidoses , but from keratin peptides of necrotic keratinocytes . Even several years ago , chronic scratching was invoked as a possible cause of damage to keratinocytes in lichen amyloidosus . In support of this hypothesis , four cases are presented . Apart from amyloid in the papillary layer , all biopsy specimens revealed histopathological signs of chronic scratching ( epithelial hyperplasia with hypergranulosis and compact orthokeratosis , coarse collagen in vertical streaks in the stratum papillare ) , such as are also found in prurigo nodularis and lichen simplex chronicus . Lichen amyloidosus is considered to be a variant of these conditions . Just as in prurigo nodularis and lichen simplex chronicus , pruritus seems to be the cause and not a symptom of the papular skin lesions . Consequently , treatment of lichen amyloidosus should not be directed at removing amyloid , but at improving the pruritus ."
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DerHautarzt.50460173.eng.abstr
|
DerHautarzt.50460173.eng.abstr
|
[
{
"id": "DerHautarzt.50460173.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . We report on a 76-year-old female patient with clinical findings consistent with necrolytic migratory erythema . Plasma glucagon levels were slightly elevated , but advanced radiologic techniques revealed no evidence of an underlying pancreatic tumour . The dermatosis responded excellently to oral therapy with dapsone . The possible aetiology and pathogenesis of the \" pseudoglucagonoma syndrome \" are discussed ."
],
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DerHautarzt.50460177.eng.abstr
|
DerHautarzt.50460177.eng.abstr
|
[
{
"id": "DerHautarzt.50460177.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . Nucleolus organizer regions are segments of DNA-coding ribosomal genes , which can be visualized histologically by a special silver staining technique as so-called AgNORs . Determination of the number and size of AgNORs provides quite a precise reflection of current cellular proliferation activity . We have examined the AgNOR expression in 228 melanocytic , epidermal and fibrohistiocytic lesions . Dysplastic naevi and Spitz naevi showed a significantly lower AgNOR expression than melanomas , and there were analogous differences between keratoacanthomas and carcinomas . Furthermore , there were also significant differences between the groups of melanomas and carcinomas , as there were between benign and non-benign fibrohistiocytic lesions . The AgNOR expression in more cellular fibrohistiocytic lesions differed from that in more fibrous lesions . Analysis of AgNOR areas was not so informative as AgNOR counting . The results of PCNA examinations correlated with the degree of AgNOR expression . It was found that the AgNOR technique is useful in differential diagnosis and for histological determinations of proliferation activity in melanocytic , epidermal and fibrohistiocytic lesions . The AgNOR method is easy to apply and can be applied in paraffin-embedded tissue ."
],
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1294
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]
}
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"id": "DerHautarzt.50460177.eng.abstr-s2-t3",
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"id": "DerHautarzt.50460177.eng.abstr-s2-t6",
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"id": "DerHautarzt.50460177.eng.abstr-s3-t1",
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"Determination"
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{
"id": "DerHautarzt.50460177.eng.abstr-s3-t2",
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"cellular proliferation"
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"id": "DerHautarzt.50460177.eng.abstr-s5-t1",
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"naevi"
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"id": "DerHautarzt.50460177.eng.abstr-s5-t3",
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"id": "DerHautarzt.50460177.eng.abstr-s5-t6",
"type": "umlsterm",
"text": [
"Dysplastic naevi"
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{
"id": "DerHautarzt.50460177.eng.abstr-s5-t7",
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"id": "DerHautarzt.50460177.eng.abstr-s6-t2",
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"carcinomas"
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"id": "DerHautarzt.50460177.eng.abstr-s8-t1",
"type": "umlsterm",
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}
] |
[] |
[] |
[
{
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DerHautarzt.50460186.eng.abstr
|
DerHautarzt.50460186.eng.abstr
|
[
{
"id": "DerHautarzt.50460186.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . We report on a male patient with mycosis fungoides ( MF ) with blisters mainly occurring on clinically uninvolved skin . This rare association has to be differentiated from other bullous diseases of the skin . The clinical picture has been known since the end of the last century and has been described as mycosis fungoides bullosa . The pathomechanism , however , has not yet been exactly identified . The different clinical and histological features of the disease are discussed ."
],
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[
0,
493
]
]
}
] |
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{
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"id": "DerHautarzt.50460186.eng.abstr-s2-t1",
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{
"id": "DerHautarzt.50460186.eng.abstr-s2-t3",
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"id": "DerHautarzt.50460186.eng.abstr-s4-t1",
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[] |
[] |
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"id": "DerHautarzt.50460186.eng.abstr-s2-r17-t4.1-t5.1",
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{
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{
"id": "DerHautarzt.50460186.eng.abstr-s2-r19-t1.1-t3.1",
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{
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DerHautarzt.50460194.eng.abstr
|
DerHautarzt.50460194.eng.abstr
|
[
{
"id": "DerHautarzt.50460194.eng.abstr-passage-0",
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"Abstract . We report on a patient with multicentric juvenile xanthogranuloma , whose unusual clinical and histological pattern initially obscured the diagnosis . Spontaneous remission of the tumour , which has now been maintained for over 2 years , the change from the primary monomorphological fibrocytic appearance to a polymorphological histiocytic picture with multiple fat-storing giant cells , and the lacking demonstration of specific cell organelles finally allowed the nature of the disease to the definitely diagnosed ."
],
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[
0,
529
]
]
}
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] |
[] |
[] |
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DerHautarzt.50460198.eng.abstr
|
DerHautarzt.50460198.eng.abstr
|
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"Abstract . This report describes the manifestation of porocarcinomas , precancerous keratoses , multiple basal cell carcinomas and palmoplantar keratoses after treatment of psoriasis vulgaris with liquor fowleri ( Fowlers solution ) containing arsenic 30 years before ; in addition , Laugier-Hunziker-Baran syndrome was diagnosed ."
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[] |
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DerHautarzt.50460204.eng.abstr
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DerHautarzt.50460204.eng.abstr
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"Abstract . The contribution of Rudolf Virchow to dermatology seems to have been forgotten , or present-day dermatologists are not aware of it . The present historical review is intended to show that Virchow's thoughts and the terminology created by him are still alive . The report encompasses a short biography , including Virchow's nonmedical activities . It starts with early experimental publications , which laid to the foundation for his fame , and with dermatological studies of his early period . This is followed by a detailed description of his contributions pertaining to dermatology in his largest work , \" Cellularpathologie \" . Special mention is made of Virchow's lasting contributions to medical , and particularly dermatological , terminology . Finally , his historical studies , his latter small publications on topics in dermatology , his pupils and scientific friends , and the social-political and anthropological activities of later years are discussed . Thus , a multifaceted picture is painted of a still modern pathologist who has influenced dermatology in multiple ways ."
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[] |
[] |
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DerHautarzt.50460225.eng.abstr
|
DerHautarzt.50460225.eng.abstr
|
[
{
"id": "DerHautarzt.50460225.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The major histocompatibility complex ( MHC ) is a large region of highly polymorphic genes . MHC-encoded molecules bind foreign-protein antigens and form complexes that are recognized by antigen-specific T lymphocytes . Interactions between MHC-peptide complexes and T-cell receptors play a central role in the selection of the T-cell repertoire and in the elicitation of an immune response . The majority of disease associations with the MHC have been with class-II molecules . Despite the awareness of such associations , the pathophysiological role of MHC class-II molecules in conferring susceptibility to autoimmune disease is poorly understood . The recent demonstration that human class-II molecules can function as antigen-presenting molecules in vivo in a transgenic murine system paves the way to investigate the role of HLA class II molecules in regulating immune responses and disease susceptibility . These mice should be useful for studying the mechanisms by which particular human leukocyte antigen ( HLA ) alleles are associated with specific human-autoimmune diseases ."
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] |
[] |
[] |
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] |
DerHautarzt.50460228.eng.abstr
|
DerHautarzt.50460228.eng.abstr
|
[
{
"id": "DerHautarzt.50460228.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Topical corticosteroids ( CS ) are frequently used to treat of allergic contact dermatitis , so that their own potential for sensitization is rarely detected . However , increasing numbers of hypersensitivity reactions to corticosteroids have been reported during the last 10 years , and allergic skin reactions to over 50 particular compounds have been observed . CS must now be regarded as a rather frequent contact allergen , the prevalence being twice as high in women as in men . Contact allergy to CS is clinically characterized by a chronic and persistent , corticosteroid-resistant dermatitis . In general , hypersensitivity to CS is a type I and/or type IV mediated allergic reaction . Cross-sensitivity between individual corticosteroid preparations has been described owing to their closely related chemical structures ( e.g. hydrocortisone and tixocortol pivalate ) . Contact allergy to CS can be confirmed by patch-tests , intradermal injection tests or application tests ; because of the delayed appearance of positive skin reactions a prolonged evaluation period of up to 120 h is recommended . For routine screening the use of the patient's own material and of tixocortol pivalate and budesonide as test marker substances seems appropriate . The development of further marker substances is a target for ongoing research ."
],
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[
0,
1337
]
]
}
] |
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"id": "DerHautarzt.50460228.eng.abstr-s6-t1",
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[] |
[] |
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DerHautarzt.50460244.eng.abstr
|
DerHautarzt.50460244.eng.abstr
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"Keratoacanthomas are made up of the same spinocellular differentiated cell material as squamous cell carcinomas , but they differ from the latter in origin and growth properties . The majority - in our series 98% of 741 examined cases - are of the \" crateriform \" type , which after rapid growth during the initial stage give way to spontaneous regression , mostly with complete restoration of the cutaneous structure . Less than 2% belong to the rare destructive variants with disturbed or absent regression and persistent invasive growth . Keratoacanthoma marginatum centrifugum , mutilating keratoacanthomas and aggregated keratoacanthomas can lead to extremely severe defects . None of the \" conservative \" treatment methods recommended in the literature up to now has proved effective , with the exception of surgery and radiotherapy with tumour ratio doses . Many publications are obviously based on uncritically interpreted individual observations ."
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DerHautarzt.50460250.eng.abstr
|
DerHautarzt.50460250.eng.abstr
|
[
{
"id": "DerHautarzt.50460250.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Scar sarcoidosis is one of the rare cutaneous manifestations of sarcoidosis . Apart from the clinical picture , suppression of the cell-mediated immunity can often be determined when tuberculin tests and testing for recall antigens are carried out . In the present case of a 68-year-old woman patient scar sarcoidosis and pulmonary sarcoidosis were detected . Remarkably , a strongly positive tuberculin reaction was found , while acute tuberculosis and former BCG vaccination were excluded . Both references in the literature and the case presented demonstrate that a positive tuberculin test , while very unusual in sarcoidosis , does not however , preclude the diagnosis . On the basis of some case reports in the literature , our patient was treated with allopurinol ; impressive improvement of both the skin and the pulmonary manifestations was noted . Despite the well-known phenomenon of spontaneous regression in sarcoidosis , we recommend a clinical trial with allopurinol as this substance is well tolerated ."
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[] |
[] |
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}
] |
DerHautarzt.50460255.eng.abstr
|
DerHautarzt.50460255.eng.abstr
|
[
{
"id": "DerHautarzt.50460255.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The presence of nicotine in sweat obtained from smokers and one non-smoker exposed to tobacco smoke after 4 h to 8 days of nicotine-free time was investigated . Following stimulation of the eccrine glands , sweat samples were taken every hour for 6 h . The total nicotine concentrations , i.e. the sum of nicotine and its metabolites , were determined by radioimmunoassay . The presence of unchanged nicotine was revealed by gas chromatography/mass spectrometry ."
],
"offsets": [
[
0,
463
]
]
}
] |
[
{
"id": "DerHautarzt.50460255.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"nicotine"
],
"offsets": [
[
16,
24
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0028040"
}
]
},
{
"id": "DerHautarzt.50460255.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"sweat"
],
"offsets": [
[
28,
33
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0038990"
},
{
"db_name": "UMLS",
"db_id": "C0038984"
}
]
},
{
"id": "DerHautarzt.50460255.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"tobacco"
],
"offsets": [
[
86,
93
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0040329"
}
]
},
{
"id": "DerHautarzt.50460255.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"smoke"
],
"offsets": [
[
94,
99
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0037366"
},
{
"db_name": "UMLS",
"db_id": "C0037369"
}
]
},
{
"id": "DerHautarzt.50460255.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"nicotine-free"
],
"offsets": [
[
123,
136
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0028040"
}
]
},
{
"id": "DerHautarzt.50460255.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"time"
],
"offsets": [
[
137,
141
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0040223"
}
]
},
{
"id": "DerHautarzt.50460255.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"sweat"
],
"offsets": [
[
207,
212
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0038990"
},
{
"db_name": "UMLS",
"db_id": "C0038984"
}
]
},
{
"id": "DerHautarzt.50460255.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"eccrine glands"
],
"offsets": [
[
190,
204
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0013492"
}
]
},
{
"id": "DerHautarzt.50460255.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"nicotine"
],
"offsets": [
[
263,
271
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0028040"
}
]
},
{
"id": "DerHautarzt.50460255.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"concentrations"
],
"offsets": [
[
272,
286
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0086045"
}
]
},
{
"id": "DerHautarzt.50460255.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"nicotine"
],
"offsets": [
[
305,
313
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0028040"
}
]
},
{
"id": "DerHautarzt.50460255.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"radioimmunoassay"
],
"offsets": [
[
355,
371
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0034580"
}
]
},
{
"id": "DerHautarzt.50460255.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"nicotine"
],
"offsets": [
[
400,
408
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0028040"
}
]
},
{
"id": "DerHautarzt.50460255.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"gas"
],
"offsets": [
[
425,
428
]
],
"normalized": [
{
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"db_id": "C0017110"
}
]
},
{
"id": "DerHautarzt.50460255.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"spectrometry"
],
"offsets": [
[
449,
461
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0037805"
}
]
}
] |
[] |
[] |
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] |
DerHautarzt.50460263.eng.abstr
|
DerHautarzt.50460263.eng.abstr
|
[
{
"id": "DerHautarzt.50460263.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . Neurofibromas , café au lait macules and freckles in the axillary or inguinal regions are common manifestations of von Recklinghausen's neurofibromatosis ( NF-1). Less known is the simultaneous appearance of dermal melanocytic naevi . We describe the case of a 21-year-old Vietnamese woman who showed generalized , multiple neurofibromas , a solitary plexiform neurofibroma in the left gluteal region and Lisch nodules . In addition , there were several large grey-blue macules histologically characterized by fusiform pigment-bearing cells in the dermis , which we diagnosed as persistent aberrant mongolian spots . In the right zygomatic region she presented a grey-blue , hair-bearing macule , which we saw as a variant of Ota's naevus . A genetic background for this coincidence of a systemic with a local phakomatosis can be supposed , as both Schwann's cells and melanocytes are derived from the neural crest . Such pathologic rearrangement in the embryogenesis of the cellular elements could be important for the pathogenesis of NF-1 and dermal melanocytic nevi ."
],
"offsets": [
[
0,
1081
]
]
}
] |
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"id": "DerHautarzt.50460263.eng.abstr-s3-t2",
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"id": "DerHautarzt.50460263.eng.abstr-s3-t3",
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"id": "DerHautarzt.50460263.eng.abstr-s3-t4",
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"id": "DerHautarzt.50460263.eng.abstr-s4-t4",
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"id": "DerHautarzt.50460263.eng.abstr-s4-t5",
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"id": "DerHautarzt.50460263.eng.abstr-s5-t2",
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}
] |
[] |
[] |
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DerHautarzt.50460268.eng.abstr
|
DerHautarzt.50460268.eng.abstr
|
[
{
"id": "DerHautarzt.50460268.eng.abstr-passage-0",
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"text": [
"We report on a 32-year-old male patient with Gorlin-Goltz syndrome , who presented with excessive numbers of superinfected basal cell carcinoma . This led us to suspect an underlying HIV infection , which was confirmed by ELISA and Western blotting . Laboratory investigation of the immunological state revealed severe immunosuppression with 267 CD4+ lymphocytes and a CD4/CD8 ratio of 0.3. The histological picture showed multiple basal cell carcinomas , some of them transforming into squamous cell carcinomas . We suspect that the excessive number and the unusual clinical and histological picture of the basal cell carcinomas in this patient were probably influenced by the underlying HIV infection ."
],
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[
0,
704
]
]
}
] |
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DerHautarzt.50460272.eng.abstr
|
DerHautarzt.50460272.eng.abstr
|
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"Abstract . We report on a 23-year-old man with hidrotic ectodermal dysplasia of the Clouston type showing a severe expression of his gene defect . As a prominent feature of this case , we describe the presence of verruciform keratoderma of hands and feet , and we visualize these skin changes by means of a new imprinting technique ."
],
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[
0,
333
]
]
}
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] |
[] |
[] |
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DerHautarzt.50460278.eng.abstr
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DerHautarzt.50460278.eng.abstr
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[] |
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DerHautarzt.50460305.eng.abstr
|
DerHautarzt.50460305.eng.abstr
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"id": "DerHautarzt.50460305.eng.abstr-passage-0",
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"Active unspecific immunotherapy in an adjuvant or palliative setting has been shown to enhance survival in melanoma patients , and gene therapy now offers new perspectives for active specific immunotherapy . Gene therapy includes the transfer of genetic material performed by either viral or non-viral methods and in vivo or ex vivo . For melanoma the following approaches are suggested : vaccination with tumour-specific , HLA-associated antigens using peptides or `naked DNA ' , vaccination with melanoma cells transfected with cytokine genes or B7, adoptive immunotherapy with specific T-lymphocytes or transfected tumour-infiltrating lymphocytes , or transfection of tumour cells with a tumour suppressor gene whose dysfunction plays a crucial role in melanoma ."
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] |
DerHautarzt.50460309.eng.abstr
|
DerHautarzt.50460309.eng.abstr
|
[
{
"id": "DerHautarzt.50460309.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Risk factors for development of malignant melanoma have been investigated in several case control studies during the last decade , with some variation in results , partly with geographical region . Four studies have been conducted under the auspices of the Central Malignant Melanoma Registry of the German Dermatological Society ; these have yielded consistent results allowing the identification of risk factors for melanoma development . The numbers of common melanocytic naevi , of atypical melanocytic naevi and the frequency of actinic lentigines were found by multivariate regression analysis to be the most important independent risk factors for melanoma development . Additional factors were hair colour , skin type and a history of naevus growth . A classification of relative risks was established by considering the first three risk factors mentioned , without any clear improvement of classification when further additional significant factors were taken into accout . For example , in individuals with more than 50 common melanocytic naevi , 5 or more atypical melanocytic naevi and simultaneous presence of actinic lentigines the risk of developing melanoma was found to be 100-fold that in persons with 10 common melanocytic naevi or fewer and without atypical melanocytic naevi or actinic lentigines . Early recognition of melanomas may be substantially improved if these risk factors are considered . Furthermore , intermittent intensive sun exposure ( sunburns as indicator ) before the age of 20 induces the development of melanocytic naevi , and after the age of 20 it contributes to the development of actinic lentigines ; both factors are associated with an increased risk of melanoma development ."
],
"offsets": [
[
0,
1721
]
]
}
] |
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DerHautarzt.50460319.eng.abstr
|
DerHautarzt.50460319.eng.abstr
|
[
{
"id": "DerHautarzt.50460319.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Wound healing represents a dynamic process of increasing scientific interest , especially with the detection of the different growth factors . Economic aspects are also of importance in the investigation of substances used for wound healing . In Germany 25% of all patients ( ca. 1 million ) with severe chronic venous insufficiency have crural ulcers . The influence of bacterial infection of crural ulcers is controversial . There is no doubt that the quantity of bacteria is of importance . Local antibiotic treatment is difficult , as most of the substances used are known to inhibit wound healing . In vivo and in vitro investigations showed , that chiniofon-containing antiseptic has a bacteriostatic function . Additionally it was shown , using cultures of fibroblasts , that chiniofon-containing antiseptic does not inhibit the growth of fibroblasts , whereas PVP-iodine solution , a widely used antiseptic , clearly reduces the growth of fibroblasts . The good clinical results in the treatment of acute and chronic radiation damage indicate that chiniofon-containing antiseptic may have antiflammatory activity ."
],
"offsets": [
[
0,
1122
]
]
}
] |
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[] |
[] |
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] |
DerHautarzt.50460325.eng.abstr
|
DerHautarzt.50460325.eng.abstr
|
[
{
"id": "DerHautarzt.50460325.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 62-year-old man presented with a nodule 2 cm in diameter on his left cheek , which he had had since childhood . Histological examination showed a circumscribed dermal nodule composed of sebaceous lobules attached to sebaceous ducts and to an infundibular cyst-like structure connected to the epidermis . The wall was lined with squamous epithelium with a stratum granulosum . This structure was reminescent of a sebaceous follicle . In addition , a melanocytic naevus of the compound type was found . Immunohistological investigations of the tumour with various cytokeratins revealed a pattern of expression characteristic for the mature sebaceous follicle ."
],
"offsets": [
[
0,
660
]
]
}
] |
[
{
"id": "DerHautarzt.50460325.eng.abstr-s1-t1",
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"text": [
"man"
],
"offsets": [
[
14,
17
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0025266"
},
{
"db_name": "UMLS",
"db_id": "C0024554"
}
]
},
{
"id": "DerHautarzt.50460325.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"cheek"
],
"offsets": [
[
71,
76
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0007966"
}
]
},
{
"id": "DerHautarzt.50460325.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"cyst-like"
],
"offsets": [
[
257,
266
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0010709"
}
]
},
{
"id": "DerHautarzt.50460325.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"epidermis"
],
"offsets": [
[
294,
303
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0014520"
}
]
},
{
"id": "DerHautarzt.50460325.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"epithelium"
],
"offsets": [
[
339,
349
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0014609"
}
]
},
{
"id": "DerHautarzt.50460325.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"follicle"
],
"offsets": [
[
424,
432
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018120"
}
]
},
{
"id": "DerHautarzt.50460325.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"naevus"
],
"offsets": [
[
463,
469
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027960"
}
]
},
{
"id": "DerHautarzt.50460325.eng.abstr-s6-t1",
"type": "umlsterm",
"text": [
"tumour"
],
"offsets": [
[
544,
550
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[] |
[] |
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DerHautarzt.50460335.eng.abstr
|
DerHautarzt.50460335.eng.abstr
|
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{
"id": "DerHautarzt.50460335.eng.abstr-passage-0",
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"text": [
"A 63-year-old woman developed a pruritic exanthema on the extremities after one hour of work in her garden pond in Planegg , Southern Bavaria . As the appropriate vectors ( ducks and snails ) were present , we made the tentative diagnosis of cercarial dermatitis ( swimmer's itch ) . By different serological methods ( cercarial fluorescent antibody test , cercarial Huellen reaction , circumoval precipitin test ) antibodies against cercariae could be demonstrated in the serum of the patient 14 days later . Cercarial dermatitis appears worldwide , but in Central Europe the disease is often not recognized ."
],
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[
0,
610
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]
}
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"id": "DerHautarzt.50460335.eng.abstr-s2-t1",
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"id": "DerHautarzt.50460335.eng.abstr-s2-t5",
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[] |
[] |
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DerHautarzt.50460339.eng.abstr
|
DerHautarzt.50460339.eng.abstr
|
[
{
"id": "DerHautarzt.50460339.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 61-year-old patient with life-threatening angioneurotic oedema was found to have an acquired C1-inhibitor ( C1-INH) deficiency . In addition to lowered serum levels of C1-INH ( both protein concentration and enzymatic activity ) , C2, C4 and CH50, which are characteristic for the hereditary form of angioneurotic oedema , markedly lowered C1q was found , which is typical for the acquired form . There were no antibodies against C1-INH. Repeated thorough examinations disclosed no neoplasm , though the presence of neoplasm has often been reported to be associated with the acquired C1-INH deficiency . However , the patient showed persistent paraproteinaemia and paraproteinuria and developed livedo reticularis . Treatment with danazol resulted in a rise in the complement fraction levels and cessation of angioneurotic oedema . Paraproteinaemia and livedo reticularis persisted unchanged ."
],
"offsets": [
[
0,
895
]
]
}
] |
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"angioneurotic oedema"
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{
"id": "DerHautarzt.50460339.eng.abstr-s2-t1",
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},
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"id": "DerHautarzt.50460339.eng.abstr-s2-t2",
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"protein"
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"oedema"
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},
{
"id": "DerHautarzt.50460339.eng.abstr-s2-t6",
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"C1q"
],
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"antibodies"
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{
"id": "DerHautarzt.50460339.eng.abstr-s3-t2",
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"neoplasm"
],
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},
{
"id": "DerHautarzt.50460339.eng.abstr-s3-t3",
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},
{
"id": "DerHautarzt.50460339.eng.abstr-s3-t4",
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"id": "DerHautarzt.50460339.eng.abstr-s4-t5",
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] |
[] |
[] |
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DerHautarzt.50460343.eng.abstr
|
DerHautarzt.50460343.eng.abstr
|
[
{
"id": "DerHautarzt.50460343.eng.abstr-passage-0",
"type": "abstract",
"text": [
"During long-term therapy of hyperuricaemia with allopurinol ( 300 mg/d ) two patients developed generalized granuloma annulare . The diagnoses were confirmed by histology ; concomitant diseases , especially diabetes mellitus , were not detectable . Following discontinuation of allopurinol therapy , cutaneous granulomas healed without relapse . Hyperuricaemia could be controlled by low-purine diet and medication avoiding allopurinol . The clinical history of our two patients suggested a causal connection between allopurinol therapy and generalized granuloma annulare . For this reason we rate the development of this disease in both cases as a rare but significant side effect of allopurinol . This should give rise to critical assessment of concomitant drug therapy during development of generalized granuloma annulare ."
],
"offsets": [
[
0,
826
]
]
}
] |
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{
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] |
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