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DerHautarzt.00510390.eng.abstr
|
DerHautarzt.00510390.eng.abstr
|
[
{
"id": "DerHautarzt.00510390.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Cytotoxic lymphomas are peripheral T- and natural killer-cell lymphomas with primary or secondary skin manifestations . They constitute a heterogenous group of lymphoproliferative disease . They are characterized by expression of cytotoxic proteins and are frequently associated with an aggressive clinical course . A brief introduction to cytotoxic lymphocytes and proteins is followed by a detailed description of clinical , histological , immunohistochemical and genetic characteristics of cutaneous cytotoxic lymophomas ."
],
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0,
525
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]
}
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{
"id": "DerHautarzt.00510390.eng.abstr-s1-t2",
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"killer-cell"
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50,
61
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{
"id": "DerHautarzt.00510390.eng.abstr-s1-t3",
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"lymphomas"
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62,
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"secondary"
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{
"id": "DerHautarzt.00510390.eng.abstr-s1-t5",
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"skin"
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"skin manifestations"
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"disease"
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"id": "DerHautarzt.00510390.eng.abstr-s2-t2",
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160,
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"id": "DerHautarzt.00510390.eng.abstr-s3-t1",
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"proteins"
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240,
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"lymphocytes"
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"id": "DerHautarzt.00510390.eng.abstr-s4-t2",
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"proteins"
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366,
374
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{
"db_name": "UMLS",
"db_id": "C0033684"
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]
}
] |
[] |
[] |
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DerHautarzt.00510396.eng.abstr
|
DerHautarzt.00510396.eng.abstr
|
[
{
"id": "DerHautarzt.00510396.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Background and Objective . To prospectively survey skin lesions in a large group of newborns , as no such study has as yet been performed in Germany ."
],
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[
0,
150
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]
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[] |
[] |
[] |
DerHautarzt.00510401.eng.abstr
|
DerHautarzt.00510401.eng.abstr
|
[
{
"id": "DerHautarzt.00510401.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Background and Objective . Psychological problems in children and parents related to children's atopic eczema ( AE ) may impede the success of treatment . We studied the question , if behavior-based parental education in groups ( DPE ) or standardized video-education ( VPE ) could enhance dermatological treatment effects and reduce skin-damaging behaviors in children and stress in their mothers ."
],
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0,
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] |
[] |
[] |
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DerHautarzt.00510416.eng.abstr
|
DerHautarzt.00510416.eng.abstr
|
[
{
"id": "DerHautarzt.00510416.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Systemic lupus erythematosus is a potentially life-threatening disease . Even the use of potent immunosuppressive drugs often barely controls the disease . In addition , treatment-related side effects are common due to the high doses of immunosuppressive drugs necessary . We report on two cases of acutely exacerbated systemic lupus erythematosus which were difficult to control with prednisone and cyclophosphamide . Both patients were additionally treated with IgM-enriched preparations of intravenous immunoglobulins . In both cases , the doses of the immunosuppressive drugs used could be significantly reduced . After nine treatment cycles , patients remained disease-free for a follow-up period of one year with only minimal immunosuppressive therapy . Our observation shows that IgM-enriched immunoglobulins can be used for therapy of systemic lupus erythematosus ."
],
"offsets": [
[
0,
873
]
]
}
] |
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] |
DerHautarzt.00510419.eng.abstr
|
DerHautarzt.00510419.eng.abstr
|
[
{
"id": "DerHautarzt.00510419.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Cutaneous angiosarcomas mainly arise on the scalp and face of older patients . They present with reddish nodules or plaques and tend to bleed and ulcerate . Angiosarcomas show an aggressive and recurrent course and have a high potential for metastasis . We report on a 48-year-old patient with unilateral eyelid edema as the first manifestation of an angiosarcoma . The clinical presentation , the history of contact allergy , the presence of antinuclear antibodies , and abnormal thyroid function tests favoured a non-neoplastic disease . However , multiple biopsies confirmed the diagnosis of a highly differentiated angiosarcoma . Staging of the patient revealed no metastasis . After radical surgery including orbital exenteration and postoperative radiation therapy , no recurrence was observed with a follow up of 26 months . This case underlines the importance of including angiosarcoma in the differential diagnosis of unilateral eyelid edema ."
],
"offsets": [
[
0,
952
]
]
}
] |
[
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"id": "DerHautarzt.00510419.eng.abstr-s1-t1",
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"text": [
"angiosarcomas"
],
"offsets": [
[
10,
23
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018923"
}
]
},
{
"id": "DerHautarzt.00510419.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"scalp"
],
"offsets": [
[
44,
49
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0036270"
}
]
},
{
"id": "DerHautarzt.00510419.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"face"
],
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[
54,
58
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0015450"
}
]
},
{
"id": "DerHautarzt.00510419.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"older"
],
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[
62,
67
]
],
"normalized": [
{
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"db_id": "C0331059"
}
]
},
{
"id": "DerHautarzt.00510419.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"patients"
],
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[
68,
76
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.00510419.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"plaques"
],
"offsets": [
[
116,
123
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011389"
},
{
"db_name": "UMLS",
"db_id": "C0333463"
}
]
},
{
"id": "DerHautarzt.00510419.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"Angiosarcomas"
],
"offsets": [
[
157,
170
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018923"
}
]
},
{
"id": "DerHautarzt.00510419.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"metastasis"
],
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[
241,
251
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027627"
}
]
},
{
"id": "DerHautarzt.00510419.eng.abstr-s4-t1",
"type": "umlsterm",
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DerHautarzt.00510423.eng.abstr
|
DerHautarzt.00510423.eng.abstr
|
[
{
"id": "DerHautarzt.00510423.eng.abstr-passage-0",
"type": "abstract",
"text": [
"An infant girl presented at birth with multiple , large nodular xanthogranulomas . Her monozygotic twin sister was not affected . The congenital tumors were up to 1.5 cm in diameter , done-shaped and mainly located on the head and the upper half of the body . Histologically the cells were characterized as CD68+ non-Langerhans histiocytes . Follow-up for 18 months showed no new tumors and regression of the existing ones . No extracutaneous manifestations were observed . Knowledge of the differential diagnosis , especially the group of Langerhans cell histiocytosis , is essential for prognosis estimation ."
],
"offsets": [
[
0,
611
]
]
}
] |
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]
}
] |
[] |
[] |
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}
] |
DerHautarzt.00510431.eng.abstr
|
DerHautarzt.00510431.eng.abstr
|
[
{
"id": "DerHautarzt.00510431.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The combination of UVB phototherapy with topical application of vitamin D analogs is frequently used for treating psoriasis . This regimen is not only very effective but also has only minimal side effects . Pronounced , persistent hyperpigmentation developed in the psoriatic plaques in a patient who was treated with combined UVB ( 311 nm ) radiation and topical calcipotriol ."
],
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[
0,
378
]
]
}
] |
[
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231,
248
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{
"id": "DerHautarzt.00510431.eng.abstr-s3-t2",
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]
},
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289,
296
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}
]
},
{
"id": "DerHautarzt.00510431.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"radiation"
],
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[
342,
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]
],
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{
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}
]
},
{
"id": "DerHautarzt.00510431.eng.abstr-s3-t5",
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364,
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]
],
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{
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"db_id": "C0065767"
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]
}
] |
[] |
[] |
[
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{
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{
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},
{
"id": "DerHautarzt.00510431.eng.abstr-s1-r12-t3.1-t2.1",
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{
"id": "DerHautarzt.00510431.eng.abstr-s3-r4-t2.1-t1.1",
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{
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},
{
"id": "DerHautarzt.00510431.eng.abstr-s3-r6-t2.2-t4.1",
"type": "result_of",
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},
{
"id": "DerHautarzt.00510431.eng.abstr-s3-r7-t5.1-t2.1",
"type": "diagnoses",
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},
{
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},
{
"id": "DerHautarzt.00510431.eng.abstr-s3-r10-t5.1-t4.1",
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"arg2_id": "DerHautarzt.00510431.eng.abstr-s3-t4",
"normalized": []
},
{
"id": "DerHautarzt.00510431.eng.abstr-s3-r11-t5.1-t1.1",
"type": "diagnoses",
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},
{
"id": "DerHautarzt.00510431.eng.abstr-s3-r12-t5.1-t2.2",
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},
{
"id": "DerHautarzt.00510431.eng.abstr-s3-r13-t1.1-t3.1",
"type": "occurs_in",
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"arg2_id": "DerHautarzt.00510431.eng.abstr-s3-t3",
"normalized": []
},
{
"id": "DerHautarzt.00510431.eng.abstr-s3-r14-t4.1-t2.2",
"type": "result_of",
"arg1_id": "DerHautarzt.00510431.eng.abstr-s3-t4",
"arg2_id": "DerHautarzt.00510431.eng.abstr-s3-t2",
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},
{
"id": "DerHautarzt.00510431.eng.abstr-s3-r16-t1.1-t2.1",
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},
{
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"arg2_id": "DerHautarzt.00510431.eng.abstr-s3-t3",
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},
{
"id": "DerHautarzt.00510431.eng.abstr-s3-r18-t2.2-t3.1",
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},
{
"id": "DerHautarzt.00510431.eng.abstr-s3-r19-t4.1-t2.1",
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{
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},
{
"id": "DerHautarzt.00510431.eng.abstr-s3-r21-t2.2-t1.1",
"type": "result_of",
"arg1_id": "DerHautarzt.00510431.eng.abstr-s3-t2",
"arg2_id": "DerHautarzt.00510431.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "DerHautarzt.00510431.eng.abstr-s3-r22-t5.1-t2.1",
"type": "affects",
"arg1_id": "DerHautarzt.00510431.eng.abstr-s3-t5",
"arg2_id": "DerHautarzt.00510431.eng.abstr-s3-t2",
"normalized": []
}
] |
DerHautarzt.00510434.eng.abstr
|
DerHautarzt.00510434.eng.abstr
|
[
{
"id": "DerHautarzt.00510434.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A patient developed a trophic ulceration of the nose after an acute bulbar ischemia with infarction of the right trigeminal nuclei . Neurologic examination showed symptoms of a Wallenberg syndrome including ipsilateral hyp- and paresthesia of the second trigeminal branch and disturbed sensibility and temperature sense on the contralateral half of the body . The right ala nasi showed the characteristic sickle-shaped defect ( ulcération en arc ) . The differential diagnosis and therapeutic approaches are discussed ."
],
"offsets": [
[
0,
519
]
]
}
] |
[
{
"id": "DerHautarzt.00510434.eng.abstr-s1-t1",
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"patient"
],
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[
2,
9
]
],
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"Numerous courses on alternative medicine are regularly advertised in Deutsches Aerzteblatt , the organ of the German Medical Association . The present German legislation likewise supports this form of medicine , and this explains why Iscador , an extract of the mistletoe , is found in the Rote Liste , a directory of commercially available medical drugs , under the heading \" cytostatic and antimetastatic drugs \" although such beneficial effect is unproven . To give another example , a German health insurance fund was sentenced to pay for acupuncture as a treatment for hepatic failure . This judgement is characteristic of the present German judicial system and represents a victory of \" oracling irrationalism \" ( Popper ) . The astonishing popularity of alternative medicine can be explained by a revival of romanticism . An intellectually fair opposite position has been delineated by Karl Popper in the form of critical rationalism . It is important to realize , however , that our decision to adhere to rational thinking is made in the innermost depth of our heart but not on the basis of rational arguing . Rather , the decision in favor of reason has a moral dimension ."
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"arg1_id": "DerHautarzt.00510439.eng.abstr-s3-t7",
"arg2_id": "DerHautarzt.00510439.eng.abstr-s3-t5",
"normalized": []
},
{
"id": "DerHautarzt.00510439.eng.abstr-s3-r7-t5.2-t1.1",
"type": "isa",
"arg1_id": "DerHautarzt.00510439.eng.abstr-s3-t5",
"arg2_id": "DerHautarzt.00510439.eng.abstr-s7-t1",
"normalized": []
},
{
"id": "DerHautarzt.00510439.eng.abstr-s3-r8-t7.1-t3.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.00510439.eng.abstr-s3-t7",
"arg2_id": "DerHautarzt.00510439.eng.abstr-s3-t3",
"normalized": []
},
{
"id": "DerHautarzt.00510439.eng.abstr-s3-r9-t5.2-t2.1",
"type": "isa",
"arg1_id": "DerHautarzt.00510439.eng.abstr-s3-t5",
"arg2_id": "DerHautarzt.00510439.eng.abstr-s5-t2",
"normalized": []
},
{
"id": "DerHautarzt.00510439.eng.abstr-s5-r1-t1.2-t2.1",
"type": "issue_in",
"arg1_id": "DerHautarzt.00510439.eng.abstr-s5-t1",
"arg2_id": "DerHautarzt.00510439.eng.abstr-s5-t2",
"normalized": []
},
{
"id": "DerHautarzt.00510439.eng.abstr-s5-r2-t1.2-t1.1",
"type": "issue_in",
"arg1_id": "DerHautarzt.00510439.eng.abstr-s5-t1",
"arg2_id": "DerHautarzt.00510439.eng.abstr-s7-t1",
"normalized": []
}
] |
DerHautarzt.00510463.eng.abstr
|
DerHautarzt.00510463.eng.abstr
|
[
{
"id": "DerHautarzt.00510463.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Many different laser systems are used in dermatology . To wisely choose the correct laser for a given problem , one must be aware of both the spectrum of disorders for which each laser is suited and the potential side effects . We compare the side effect and complication profiles of the common laser systems pointing out their possibilities and limitations . Typical treatment errors will be pointed out . Dermatological training , extensive experience in laser therapy and compliance with quality guidelines are prerequisites for safe and successful treatment ."
],
"offsets": [
[
0,
563
]
]
}
] |
[
{
"id": "DerHautarzt.00510463.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"laser"
],
"offsets": [
[
15,
20
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0023089"
}
]
},
{
"id": "DerHautarzt.00510463.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"dermatology"
],
"offsets": [
[
41,
52
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011627"
}
]
},
{
"id": "DerHautarzt.00510463.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"laser"
],
"offsets": [
[
84,
89
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0023089"
}
]
},
{
"id": "DerHautarzt.00510463.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"disorders"
],
"offsets": [
[
154,
163
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0012634"
}
]
},
{
"id": "DerHautarzt.00510463.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"laser"
],
"offsets": [
[
179,
184
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0023089"
}
]
},
{
"id": "DerHautarzt.00510463.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"side effects"
],
"offsets": [
[
213,
225
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0001688"
}
]
},
{
"id": "DerHautarzt.00510463.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"complication"
],
"offsets": [
[
259,
271
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0009566"
}
]
},
{
"id": "DerHautarzt.00510463.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"laser"
],
"offsets": [
[
295,
300
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0023089"
}
]
},
{
"id": "DerHautarzt.00510463.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"side effect"
],
"offsets": [
[
243,
254
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0001688"
}
]
},
{
"id": "DerHautarzt.00510463.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"treatment"
],
"offsets": [
[
368,
377
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0087111"
},
{
"db_name": "UMLS",
"db_id": "C0039798"
}
]
},
{
"id": "DerHautarzt.00510463.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"training"
],
"offsets": [
[
422,
430
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0040607"
},
{
"db_name": "UMLS",
"db_id": "C0220931"
}
]
},
{
"id": "DerHautarzt.00510463.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"laser"
],
"offsets": [
[
457,
462
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0023089"
}
]
},
{
"id": "DerHautarzt.00510463.eng.abstr-s5-t3",
"type": "umlsterm",
"text": [
"therapy"
],
"offsets": [
[
463,
470
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0087111"
},
{
"db_name": "UMLS",
"db_id": "C0039798"
}
]
},
{
"id": "DerHautarzt.00510463.eng.abstr-s5-t4",
"type": "umlsterm",
"text": [
"compliance"
],
"offsets": [
[
475,
485
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030680"
},
{
"db_name": "UMLS",
"db_id": "C0009563"
}
]
},
{
"id": "DerHautarzt.00510463.eng.abstr-s5-t5",
"type": "umlsterm",
"text": [
"guidelines"
],
"offsets": [
[
499,
509
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0220845"
},
{
"db_name": "UMLS",
"db_id": "C0162791"
},
{
"db_name": "UMLS",
"db_id": "C0282423"
}
]
},
{
"id": "DerHautarzt.00510463.eng.abstr-s5-t6",
"type": "umlsterm",
"text": [
"treatment"
],
"offsets": [
[
552,
561
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0087111"
},
{
"db_name": "UMLS",
"db_id": "C0039798"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.00510463.eng.abstr-s1-r1-t1.1-t2.1",
"type": "issue_in",
"arg1_id": "DerHautarzt.00510463.eng.abstr-s5-t1",
"arg2_id": "DerHautarzt.00510463.eng.abstr-s5-t2",
"normalized": []
},
{
"id": "DerHautarzt.00510463.eng.abstr-s2-r1-t3.1-t2.1",
"type": "causes",
"arg1_id": "DerHautarzt.00510463.eng.abstr-s5-t3",
"arg2_id": "DerHautarzt.00510463.eng.abstr-s5-t2",
"normalized": []
},
{
"id": "DerHautarzt.00510463.eng.abstr-s2-r2-t2.1-t4.1",
"type": "result_of",
"arg1_id": "DerHautarzt.00510463.eng.abstr-s5-t2",
"arg2_id": "DerHautarzt.00510463.eng.abstr-s5-t4",
"normalized": []
},
{
"id": "DerHautarzt.00510463.eng.abstr-s2-r3-t2.1-t4.1",
"type": "degree_of",
"arg1_id": "DerHautarzt.00510463.eng.abstr-s5-t2",
"arg2_id": "DerHautarzt.00510463.eng.abstr-s5-t4",
"normalized": []
},
{
"id": "DerHautarzt.00510463.eng.abstr-s2-r4-t3.1-t4.1",
"type": "causes",
"arg1_id": "DerHautarzt.00510463.eng.abstr-s5-t3",
"arg2_id": "DerHautarzt.00510463.eng.abstr-s5-t4",
"normalized": []
},
{
"id": "DerHautarzt.00510463.eng.abstr-s2-r5-t4.1-t2.1",
"type": "result_of",
"arg1_id": "DerHautarzt.00510463.eng.abstr-s5-t4",
"arg2_id": "DerHautarzt.00510463.eng.abstr-s5-t2",
"normalized": []
},
{
"id": "DerHautarzt.00510463.eng.abstr-s2-r6-t1.1-t2.1",
"type": "causes",
"arg1_id": "DerHautarzt.00510463.eng.abstr-s5-t1",
"arg2_id": "DerHautarzt.00510463.eng.abstr-s5-t2",
"normalized": []
},
{
"id": "DerHautarzt.00510463.eng.abstr-s2-r7-t4.1-t2.1",
"type": "degree_of",
"arg1_id": "DerHautarzt.00510463.eng.abstr-s5-t4",
"arg2_id": "DerHautarzt.00510463.eng.abstr-s5-t2",
"normalized": []
},
{
"id": "DerHautarzt.00510463.eng.abstr-s2-r8-t1.1-t4.1",
"type": "causes",
"arg1_id": "DerHautarzt.00510463.eng.abstr-s5-t1",
"arg2_id": "DerHautarzt.00510463.eng.abstr-s5-t4",
"normalized": []
},
{
"id": "DerHautarzt.00510463.eng.abstr-s3-r1-t1.1-t3.1",
"type": "causes",
"arg1_id": "DerHautarzt.00510463.eng.abstr-s5-t1",
"arg2_id": "DerHautarzt.00510463.eng.abstr-s5-t3",
"normalized": []
},
{
"id": "DerHautarzt.00510463.eng.abstr-s3-r2-t1.1-t3.1",
"type": "result_of",
"arg1_id": "DerHautarzt.00510463.eng.abstr-s5-t1",
"arg2_id": "DerHautarzt.00510463.eng.abstr-s5-t3",
"normalized": []
},
{
"id": "DerHautarzt.00510463.eng.abstr-s3-r3-t3.1-t1.1",
"type": "result_of",
"arg1_id": "DerHautarzt.00510463.eng.abstr-s5-t3",
"arg2_id": "DerHautarzt.00510463.eng.abstr-s5-t1",
"normalized": []
},
{
"id": "DerHautarzt.00510463.eng.abstr-s5-r1-t4.2-t1.1",
"type": "conceptual_part_of",
"arg1_id": "DerHautarzt.00510463.eng.abstr-s5-t4",
"arg2_id": "DerHautarzt.00510463.eng.abstr-s5-t1",
"normalized": []
},
{
"id": "DerHautarzt.00510463.eng.abstr-s5-r2-t4.2-t3.1",
"type": "conceptual_part_of",
"arg1_id": "DerHautarzt.00510463.eng.abstr-s5-t4",
"arg2_id": "DerHautarzt.00510463.eng.abstr-s5-t3",
"normalized": []
},
{
"id": "DerHautarzt.00510463.eng.abstr-s5-r3-t4.2-t6.1",
"type": "conceptual_part_of",
"arg1_id": "DerHautarzt.00510463.eng.abstr-s5-t4",
"arg2_id": "DerHautarzt.00510463.eng.abstr-s5-t6",
"normalized": []
}
] |
DerHautarzt.00510474.eng.abstr
|
DerHautarzt.00510474.eng.abstr
|
[
{
"id": "DerHautarzt.00510474.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Background and Objecitve . Actinic prurigo ( AP ) is a hereditary photodermatosis with typical symptoms and is quite common in North- and South-America . The key genetic factor appears to be a Native American background . In Europeans this type of AP is extremely rare ; some dispute if this disease exists in Caucasians . Some newer publications postulate that these patients share HLA markers with the Native Americans . The most important differential diagnosis for AP is polymorphic light eruption which can be excluded relatively accurately by the clinical picture , typical histology and HLA pattern ."
],
"offsets": [
[
0,
607
]
]
}
] |
[
{
"id": "DerHautarzt.00510474.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"prurigo"
],
"offsets": [
[
35,
42
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0033771"
}
]
},
{
"id": "DerHautarzt.00510474.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"photodermatosis"
],
"offsets": [
[
66,
81
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0751995"
}
]
},
{
"id": "DerHautarzt.00510474.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"symptoms"
],
"offsets": [
[
95,
103
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0683368"
}
]
},
{
"id": "DerHautarzt.00510474.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"South-America"
],
"offsets": [
[
138,
151
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0002454"
}
]
},
{
"id": "DerHautarzt.00510474.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"Native"
],
"offsets": [
[
193,
199
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0079891"
}
]
},
{
"id": "DerHautarzt.00510474.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"Native American"
],
"offsets": [
[
193,
208
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0282204"
}
]
},
{
"id": "DerHautarzt.00510474.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"disease"
],
"offsets": [
[
292,
299
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0012634"
}
]
},
{
"id": "DerHautarzt.00510474.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"Caucasians"
],
"offsets": [
[
310,
320
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0043157"
}
]
},
{
"id": "DerHautarzt.00510474.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"publications"
],
"offsets": [
[
334,
346
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0034036"
}
]
},
{
"id": "DerHautarzt.00510474.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"patients"
],
"offsets": [
[
368,
376
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.00510474.eng.abstr-s5-t3",
"type": "umlsterm",
"text": [
"HLA"
],
"offsets": [
[
383,
386
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0019721"
}
]
},
{
"id": "DerHautarzt.00510474.eng.abstr-s5-t4",
"type": "umlsterm",
"text": [
"markers"
],
"offsets": [
[
387,
394
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0005516"
}
]
},
{
"id": "DerHautarzt.00510474.eng.abstr-s5-t5",
"type": "umlsterm",
"text": [
"Native"
],
"offsets": [
[
404,
410
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0079891"
}
]
},
{
"id": "DerHautarzt.00510474.eng.abstr-s5-t6",
"type": "umlsterm",
"text": [
"Native Americans"
],
"offsets": [
[
404,
420
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0282204"
}
]
},
{
"id": "DerHautarzt.00510474.eng.abstr-s6-t1",
"type": "umlsterm",
"text": [
"diagnosis"
],
"offsets": [
[
455,
464
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011900"
},
{
"db_name": "UMLS",
"db_id": "C0348026"
}
]
},
{
"id": "DerHautarzt.00510474.eng.abstr-s6-t2",
"type": "umlsterm",
"text": [
"light"
],
"offsets": [
[
487,
492
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0023693"
}
]
},
{
"id": "DerHautarzt.00510474.eng.abstr-s6-t3",
"type": "umlsterm",
"text": [
"histology"
],
"offsets": [
[
580,
589
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0019638"
},
{
"db_name": "UMLS",
"db_id": "C0205462"
}
]
},
{
"id": "DerHautarzt.00510474.eng.abstr-s6-t4",
"type": "umlsterm",
"text": [
"HLA"
],
"offsets": [
[
594,
597
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0019721"
}
]
},
{
"id": "DerHautarzt.00510474.eng.abstr-s6-t5",
"type": "umlsterm",
"text": [
"differential diagnosis"
],
"offsets": [
[
442,
464
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0220820"
},
{
"db_name": "UMLS",
"db_id": "C0011906"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.00510474.eng.abstr-s2-r1-t2.1-t1.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.00510474.eng.abstr-s6-t2",
"arg2_id": "DerHautarzt.00510474.eng.abstr-s6-t1",
"normalized": []
},
{
"id": "DerHautarzt.00510474.eng.abstr-s2-r2-t1.1-t3.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.00510474.eng.abstr-s6-t1",
"arg2_id": "DerHautarzt.00510474.eng.abstr-s6-t3",
"normalized": []
},
{
"id": "DerHautarzt.00510474.eng.abstr-s2-r3-t2.1-t1.1",
"type": "location_of",
"arg1_id": "DerHautarzt.00510474.eng.abstr-s6-t2",
"arg2_id": "DerHautarzt.00510474.eng.abstr-s6-t1",
"normalized": []
},
{
"id": "DerHautarzt.00510474.eng.abstr-s2-r4-t1.1-t2.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.00510474.eng.abstr-s6-t1",
"arg2_id": "DerHautarzt.00510474.eng.abstr-s6-t2",
"normalized": []
},
{
"id": "DerHautarzt.00510474.eng.abstr-s2-r5-t3.1-t1.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.00510474.eng.abstr-s6-t3",
"arg2_id": "DerHautarzt.00510474.eng.abstr-s6-t1",
"normalized": []
},
{
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},
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},
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},
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},
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"id": "DerHautarzt.00510474.eng.abstr-s5-r7-t6.1-t1.1",
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},
{
"id": "DerHautarzt.00510474.eng.abstr-s6-r1-t1.1-t3.1",
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},
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"id": "DerHautarzt.00510474.eng.abstr-s6-r3-t5.1-t3.1",
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},
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"id": "DerHautarzt.00510474.eng.abstr-s6-r4-t5.1-t1.2",
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},
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"id": "DerHautarzt.00510474.eng.abstr-s6-r6-t3.2-t1.2",
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},
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}
] |
DerHautarzt.00510486.eng.abstr
|
DerHautarzt.00510486.eng.abstr
|
[
{
"id": "DerHautarzt.00510486.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Background and Objective . Stage IV melanoma patients with progressive disease are a therapeutic challenge for every dermatologist . We wondered whether a mild oral chemotherapy with trofosfamide would ameliorate disease progression in these patients ."
],
"offsets": [
[
0,
252
]
]
}
] |
[
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15,
24
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}
]
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{
"id": "DerHautarzt.00510486.eng.abstr-s2-t1",
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"Stage"
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[
27,
32
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}
]
},
{
"id": "DerHautarzt.00510486.eng.abstr-s2-t2",
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"melanoma"
],
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[
36,
44
]
],
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{
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"db_id": "C0025202"
}
]
},
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"id": "DerHautarzt.00510486.eng.abstr-s2-t3",
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"patients"
],
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[
45,
53
]
],
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}
]
},
{
"id": "DerHautarzt.00510486.eng.abstr-s2-t4",
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"disease"
],
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[
71,
78
]
],
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{
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}
]
},
{
"id": "DerHautarzt.00510486.eng.abstr-s2-t5",
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"therapeutic"
],
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[
85,
96
]
],
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{
"db_name": "UMLS",
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}
]
},
{
"id": "DerHautarzt.00510486.eng.abstr-s3-t1",
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"chemotherapy"
],
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[
165,
177
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}
]
},
{
"id": "DerHautarzt.00510486.eng.abstr-s3-t2",
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[
183,
195
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}
]
},
{
"id": "DerHautarzt.00510486.eng.abstr-s3-t3",
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],
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213,
220
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],
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{
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}
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},
{
"id": "DerHautarzt.00510486.eng.abstr-s3-t4",
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"patients"
],
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[
242,
250
]
],
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{
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}
]
},
{
"id": "DerHautarzt.00510486.eng.abstr-s3-t5",
"type": "umlsterm",
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"disease progression"
],
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[
213,
232
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0242656"
}
]
}
] |
[] |
[] |
[
{
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{
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},
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},
{
"id": "DerHautarzt.00510486.eng.abstr-s2-r11-t1.1-t3.1",
"type": "affects",
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},
{
"id": "DerHautarzt.00510486.eng.abstr-s2-r12-t2.1-t4.1",
"type": "degree_of",
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},
{
"id": "DerHautarzt.00510486.eng.abstr-s2-r13-t4.1-t5.1",
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"normalized": []
},
{
"id": "DerHautarzt.00510486.eng.abstr-s2-r14-t5.1-t2.1",
"type": "associated_with",
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"normalized": []
},
{
"id": "DerHautarzt.00510486.eng.abstr-s2-r15-t2.1-t1.1",
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},
{
"id": "DerHautarzt.00510486.eng.abstr-s2-r16-t1.1-t5.1",
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},
{
"id": "DerHautarzt.00510486.eng.abstr-s2-r17-t1.1-t4.1",
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"arg2_id": "DerHautarzt.00510486.eng.abstr-s3-t4",
"normalized": []
},
{
"id": "DerHautarzt.00510486.eng.abstr-s2-r18-t1.1-t2.1",
"type": "associated_with",
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"arg2_id": "DerHautarzt.00510486.eng.abstr-s3-t2",
"normalized": []
},
{
"id": "DerHautarzt.00510486.eng.abstr-s3-r1-t1.2-t5.1",
"type": "associated_with",
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"arg2_id": "DerHautarzt.00510486.eng.abstr-s3-t5",
"normalized": []
},
{
"id": "DerHautarzt.00510486.eng.abstr-s3-r2-t2.1-t1.2",
"type": "affects",
"arg1_id": "DerHautarzt.00510486.eng.abstr-s3-t2",
"arg2_id": "DerHautarzt.00510486.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "DerHautarzt.00510486.eng.abstr-s3-r3-t2.1-t1.2",
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},
{
"id": "DerHautarzt.00510486.eng.abstr-s3-r4-t5.1-t1.2",
"type": "associated_with",
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},
{
"id": "DerHautarzt.00510486.eng.abstr-s3-r5-t4.1-t1.1",
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},
{
"id": "DerHautarzt.00510486.eng.abstr-s3-r7-t2.1-t1.2",
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},
{
"id": "DerHautarzt.00510486.eng.abstr-s3-r8-t1.2-t2.1",
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},
{
"id": "DerHautarzt.00510486.eng.abstr-s3-r10-t1.2-t4.1",
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},
{
"id": "DerHautarzt.00510486.eng.abstr-s3-r12-t1.1-t4.1",
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},
{
"id": "DerHautarzt.00510486.eng.abstr-s3-r13-t1.1-t2.1",
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"arg2_id": "DerHautarzt.00510486.eng.abstr-s3-t2",
"normalized": []
}
] |
DerHautarzt.00510490.eng.abstr
|
DerHautarzt.00510490.eng.abstr
|
[
{
"id": "DerHautarzt.00510490.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Background and Objective . The clinical differentiation of the hereditary ichthyosis forms is difficult and without laboratory markers hardly possible . Serum lipoprotein electrophoresis is one tool for detecting patients with recessive X-linked ichthyosis ( XRI ) . Compared to controls , XRI patients show elevated electrophoretic mobilities of low density ( LDL ) and very low density lipoproteins ( VLDL ) . This change in pattern is only partially explained by the increased LDL cholesterin sulfate concentration and is the subject of this study ."
],
"offsets": [
[
0,
552
]
]
}
] |
[
{
"id": "DerHautarzt.00510490.eng.abstr-s1-t1",
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"Objective"
],
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15,
24
]
],
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"db_id": "C0018017"
}
]
},
{
"id": "DerHautarzt.00510490.eng.abstr-s2-t1",
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"text": [
"ichthyosis"
],
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[
74,
84
]
],
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"db_name": "UMLS",
"db_id": "C0020757"
}
]
},
{
"id": "DerHautarzt.00510490.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"forms"
],
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[
85,
90
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0376315"
}
]
},
{
"id": "DerHautarzt.00510490.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"laboratory"
],
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[
116,
126
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0022877"
}
]
},
{
"id": "DerHautarzt.00510490.eng.abstr-s2-t4",
"type": "umlsterm",
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"markers"
],
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[
127,
134
]
],
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{
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"db_id": "C0005516"
}
]
},
{
"id": "DerHautarzt.00510490.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"laboratory markers"
],
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[
116,
134
]
],
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{
"db_name": "UMLS",
"db_id": "C0162490"
}
]
},
{
"id": "DerHautarzt.00510490.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"lipoprotein"
],
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[
159,
170
]
],
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{
"db_name": "UMLS",
"db_id": "C0023820"
}
]
},
{
"id": "DerHautarzt.00510490.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"electrophoresis"
],
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[
171,
186
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0013855"
}
]
},
{
"id": "DerHautarzt.00510490.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"patients"
],
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[
213,
221
]
],
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{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.00510490.eng.abstr-s3-t4",
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"id": "DerHautarzt.00510490.eng.abstr-s5-t2",
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{
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]
}
] |
[] |
[] |
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"normalized": []
}
] |
DerHautarzt.00510496.eng.abstr
|
DerHautarzt.00510496.eng.abstr
|
[
{
"id": "DerHautarzt.00510496.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Background and Objective . Illness specific stress plays an important part in the daily life of psoriatic patients . Until now for the measurement of relevant aspects of daily stress only the \" Psoriasis Life Stress Inventory \" ( PLSI ) of Gupta & Gupta exists ; with the \" Psoriasis-Alltagsstress-Inventar \" ( PAI ) , a German version of the PLSI is presented and its psychometric properties are discussed ."
],
"offsets": [
[
0,
408
]
]
}
] |
[
{
"id": "DerHautarzt.00510496.eng.abstr-s1-t1",
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15,
24
]
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"db_id": "C0018017"
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]
},
{
"id": "DerHautarzt.00510496.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"stress"
],
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[
44,
50
]
],
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{
"db_name": "UMLS",
"db_id": "C0038435"
}
]
},
{
"id": "DerHautarzt.00510496.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"life"
],
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[
88,
92
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0376558"
}
]
},
{
"id": "DerHautarzt.00510496.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"patients"
],
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[
106,
114
]
],
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{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.00510496.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"measurement"
],
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[
135,
146
]
],
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"db_id": "C0242485"
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]
},
{
"id": "DerHautarzt.00510496.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"stress"
],
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[
176,
182
]
],
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{
"db_name": "UMLS",
"db_id": "C0038435"
}
]
},
{
"id": "DerHautarzt.00510496.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"Psoriasis"
],
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[
194,
203
]
],
"normalized": [
{
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"db_id": "C0033860"
}
]
},
{
"id": "DerHautarzt.00510496.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"Life"
],
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[
204,
208
]
],
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{
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}
]
},
{
"id": "DerHautarzt.00510496.eng.abstr-s3-t5",
"type": "umlsterm",
"text": [
"Stress"
],
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[
209,
215
]
],
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{
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}
]
},
{
"id": "DerHautarzt.00510496.eng.abstr-s3-t6",
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"text": [
"Inventory"
],
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[
216,
225
]
],
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{
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"db_id": "C0031213"
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{
"db_name": "UMLS",
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}
]
},
{
"id": "DerHautarzt.00510496.eng.abstr-s3-t7",
"type": "umlsterm",
"text": [
"Psoriasis-Alltagsstress-Inventar"
],
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[
274,
306
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],
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{
"db_name": "UMLS",
"db_id": "C0033860"
}
]
},
{
"id": "DerHautarzt.00510496.eng.abstr-s3-t8",
"type": "umlsterm",
"text": [
"Psoriasis-Alltagsstress-Inventar"
],
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[
274,
306
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],
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{
"db_name": "UMLS",
"db_id": "C0023449"
}
]
},
{
"id": "DerHautarzt.00510496.eng.abstr-s3-t9",
"type": "umlsterm",
"text": [
"Psoriasis-Alltagsstress-Inventar"
],
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[
274,
306
]
],
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{
"db_name": "UMLS",
"db_id": "C0039315"
}
]
},
{
"id": "DerHautarzt.00510496.eng.abstr-s3-t10",
"type": "umlsterm",
"text": [
"PAI"
],
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[
311,
314
]
],
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{
"db_name": "UMLS",
"db_id": "C0032145"
}
]
},
{
"id": "DerHautarzt.00510496.eng.abstr-s3-t11",
"type": "umlsterm",
"text": [
"psychometric"
],
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[
369,
381
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0033920"
}
]
},
{
"id": "DerHautarzt.00510496.eng.abstr-s3-t12",
"type": "umlsterm",
"text": [
"Life Stress"
],
"offsets": [
[
204,
215
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0038443"
}
]
}
] |
[] |
[] |
[
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"id": "DerHautarzt.00510496.eng.abstr-s3-r1-t9.1-t12.1",
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"id": "DerHautarzt.00510496.eng.abstr-s3-r5-t5.1-t12.1",
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{
"id": "DerHautarzt.00510496.eng.abstr-s3-r6-t9.1-t5.1",
"type": "affects",
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{
"id": "DerHautarzt.00510496.eng.abstr-s3-r7-t1.1-t6.2",
"type": "degree_of",
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{
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{
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] |
DerHautarzt.00510502.eng.abstr
|
DerHautarzt.00510502.eng.abstr
|
[
{
"id": "DerHautarzt.00510502.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 50 year old woman with distinct lichen sclerosus et atrophicus was suffering from severe genital itching , dyspareunia and increasing urinary burning . Therapy attempts with topical glucosteroids and estrogens had been without effort . Treatment with CO2 laser in silk touch mode under insufflation anesthesia to an improvement of her skin lesions and a nearly complete remission of her symptoms ."
],
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[
0,
399
]
]
}
] |
[
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"id": "DerHautarzt.00510502.eng.abstr-s1-t1",
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{
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34,
40
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],
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},
{
"id": "DerHautarzt.00510502.eng.abstr-s1-t5",
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},
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"id": "DerHautarzt.00510502.eng.abstr-s1-t7",
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"lichen sclerosus"
],
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34,
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{
"id": "DerHautarzt.00510502.eng.abstr-s2-t1",
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},
{
"id": "DerHautarzt.00510502.eng.abstr-s2-t2",
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"id": "DerHautarzt.00510502.eng.abstr-s2-t3",
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"effort"
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]
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{
"id": "DerHautarzt.00510502.eng.abstr-s3-t1",
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"Treatment"
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{
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"id": "DerHautarzt.00510502.eng.abstr-s3-t6",
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{
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"id": "DerHautarzt.00510502.eng.abstr-s3-t8",
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"id": "DerHautarzt.00510502.eng.abstr-s3-t9",
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]
}
] |
[] |
[] |
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"arg2_id": "DerHautarzt.00510502.eng.abstr-s3-t10",
"normalized": []
},
{
"id": "DerHautarzt.00510502.eng.abstr-s3-r15-t9.1-t4.1",
"type": "evaluation_of",
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},
{
"id": "DerHautarzt.00510502.eng.abstr-s3-r16-t4.1-t1.1",
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},
{
"id": "DerHautarzt.00510502.eng.abstr-s3-r17-t1.1-t4.1",
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},
{
"id": "DerHautarzt.00510502.eng.abstr-s3-r18-t1.1-t4.1",
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},
{
"id": "DerHautarzt.00510502.eng.abstr-s3-r19-t8.1-t4.1",
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},
{
"id": "DerHautarzt.00510502.eng.abstr-s3-r20-t4.1-t8.1",
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},
{
"id": "DerHautarzt.00510502.eng.abstr-s3-r21-t1.2-t4.1",
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"arg2_id": "DerHautarzt.00510502.eng.abstr-s3-t4",
"normalized": []
}
] |
DerHautarzt.00510509.eng.abstr
|
DerHautarzt.00510509.eng.abstr
|
[
{
"id": "DerHautarzt.00510509.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Two patients were infected with sporotrichosis ; one had the fixed cutaneous form , the other the lymphocutaneous form . Sporotrichosis schenckii was identified in both with a culture from a tissue biopsy . Both patients were successfully treated with itraconazole , one received 100 mg and the other 200 mg itraconazole daily over a 3 months period ."
],
"offsets": [
[
0,
351
]
]
}
] |
[
{
"id": "DerHautarzt.00510509.eng.abstr-s1-t1",
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"patients"
],
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[
4,
12
]
],
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{
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"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.00510509.eng.abstr-s1-t2",
"type": "umlsterm",
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"sporotrichosis"
],
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[
32,
46
]
],
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{
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"db_id": "C0038034"
}
]
},
{
"id": "DerHautarzt.00510509.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"form"
],
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[
114,
118
]
],
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{
"db_name": "UMLS",
"db_id": "C0376315"
}
]
},
{
"id": "DerHautarzt.00510509.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"Sporotrichosis"
],
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[
121,
135
]
],
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{
"db_name": "UMLS",
"db_id": "C0038034"
}
]
},
{
"id": "DerHautarzt.00510509.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"culture"
],
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[
176,
183
]
],
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{
"db_name": "UMLS",
"db_id": "C0220814"
},
{
"db_name": "UMLS",
"db_id": "C0010453"
}
]
},
{
"id": "DerHautarzt.00510509.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"tissue"
],
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[
191,
197
]
],
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{
"db_name": "UMLS",
"db_id": "C0040300"
}
]
},
{
"id": "DerHautarzt.00510509.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"biopsy"
],
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[
198,
204
]
],
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{
"db_name": "UMLS",
"db_id": "C0220797"
},
{
"db_name": "UMLS",
"db_id": "C0005558"
}
]
},
{
"id": "DerHautarzt.00510509.eng.abstr-s3-t1",
"type": "umlsterm",
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"patients"
],
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[
212,
220
]
],
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{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.00510509.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"itraconazole"
],
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[
252,
264
]
],
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{
"db_name": "UMLS",
"db_id": "C0064113"
}
]
},
{
"id": "DerHautarzt.00510509.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"itraconazole"
],
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[
308,
320
]
],
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{
"db_name": "UMLS",
"db_id": "C0064113"
}
]
},
{
"id": "DerHautarzt.00510509.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"period"
],
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[
343,
349
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0025344"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.00510509.eng.abstr-s1-r1-t3.1-t2.1",
"type": "causes",
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},
{
"id": "DerHautarzt.00510509.eng.abstr-s1-r2-t1.1-t3.1",
"type": "uses",
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"arg2_id": "DerHautarzt.00510509.eng.abstr-s3-t3",
"normalized": []
},
{
"id": "DerHautarzt.00510509.eng.abstr-s1-r3-t2.1-t1.1",
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"arg2_id": "DerHautarzt.00510509.eng.abstr-s3-t1",
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},
{
"id": "DerHautarzt.00510509.eng.abstr-s2-r1-t2.1-t4.1",
"type": "evaluation_of",
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},
{
"id": "DerHautarzt.00510509.eng.abstr-s2-r2-t4.1-t1.1",
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"normalized": []
},
{
"id": "DerHautarzt.00510509.eng.abstr-s2-r3-t1.1-t4.1",
"type": "associated_with",
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"arg2_id": "DerHautarzt.00510509.eng.abstr-s3-t4",
"normalized": []
},
{
"id": "DerHautarzt.00510509.eng.abstr-s2-r4-t3.1-t4.1",
"type": "location_of",
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},
{
"id": "DerHautarzt.00510509.eng.abstr-s2-r5-t1.1-t3.1",
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},
{
"id": "DerHautarzt.00510509.eng.abstr-s2-r6-t3.1-t1.1",
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},
{
"id": "DerHautarzt.00510509.eng.abstr-s3-r1-t2.1-t4.1",
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},
{
"id": "DerHautarzt.00510509.eng.abstr-s3-r2-t2.1-t3.1",
"type": "interacts_with",
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},
{
"id": "DerHautarzt.00510509.eng.abstr-s3-r3-t3.1-t4.1",
"type": "affects",
"arg1_id": "DerHautarzt.00510509.eng.abstr-s3-t3",
"arg2_id": "DerHautarzt.00510509.eng.abstr-s3-t4",
"normalized": []
},
{
"id": "DerHautarzt.00510509.eng.abstr-s3-r4-t3.1-t2.1",
"type": "interacts_with",
"arg1_id": "DerHautarzt.00510509.eng.abstr-s3-t3",
"arg2_id": "DerHautarzt.00510509.eng.abstr-s3-t2",
"normalized": []
}
] |
DerHautarzt.00510513.eng.abstr
|
DerHautarzt.00510513.eng.abstr
|
[
{
"id": "DerHautarzt.00510513.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Subcutaneous panniculitic T-cell lymphoma is categorized as a subtype of peripheral T-cell lymphoma . Patients typically present with nontender subcutaneous nodules . The characteristic histologic features include the presence of atypical lymphocytes and benign macrophages that infiltrate between the adipocytes of the subcutis mimicking panniculitis . We report a 75-year old patient with a three week history of asymptomatic subcutaneous nodules . The diagnosis of subcutaneous T-cell lymphoma was confirmed by immunohistological and molecular biolological studies . Chemotherapy had to be interrupted due to a rapid worsening of the patient's general condition . She died few weeks after confirmation of diagnosis ."
],
"offsets": [
[
0,
719
]
]
}
] |
[
{
"id": "DerHautarzt.00510513.eng.abstr-s1-t1",
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"text": [
"panniculitic"
],
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[
13,
25
]
],
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{
"db_name": "UMLS",
"db_id": "C0278076"
},
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"db_name": "UMLS",
"db_id": "C0063382"
},
{
"db_name": "UMLS",
"db_id": "C0040188"
}
]
},
{
"id": "DerHautarzt.00510513.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"T-cell"
],
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[
26,
32
]
],
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{
"db_name": "UMLS",
"db_id": "C0039194"
}
]
},
{
"id": "DerHautarzt.00510513.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"lymphoma"
],
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[
33,
41
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0024299"
}
]
},
{
"id": "DerHautarzt.00510513.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"T-cell"
],
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[
84,
90
]
],
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{
"db_name": "UMLS",
"db_id": "C0039194"
}
]
},
{
"id": "DerHautarzt.00510513.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"lymphoma"
],
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[
91,
99
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0024299"
}
]
},
{
"id": "DerHautarzt.00510513.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"T-cell lymphoma"
],
"offsets": [
[
26,
41
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0079772"
}
]
},
{
"id": "DerHautarzt.00510513.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"T-cell lymphoma"
],
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[
84,
99
]
],
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{
"db_name": "UMLS",
"db_id": "C0079772"
}
]
},
{
"id": "DerHautarzt.00510513.eng.abstr-s1-t8",
"type": "umlsterm",
"text": [
"peripheral T-cell lymphoma"
],
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[
73,
99
]
],
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{
"db_name": "UMLS",
"db_id": "C0079774"
}
]
},
{
"id": "DerHautarzt.00510513.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"Patients"
],
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[
102,
110
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.00510513.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"histologic"
],
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[
186,
196
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0205462"
}
]
},
{
"id": "DerHautarzt.00510513.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"lymphocytes"
],
"offsets": [
[
239,
250
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0024264"
}
]
},
{
"id": "DerHautarzt.00510513.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"macrophages"
],
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[
262,
273
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0024432"
}
]
},
{
"id": "DerHautarzt.00510513.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"adipocytes"
],
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[
302,
312
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],
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"db_name": "UMLS",
"db_id": "C0206131"
}
]
},
{
"id": "DerHautarzt.00510513.eng.abstr-s3-t5",
"type": "umlsterm",
"text": [
"panniculitis"
],
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[
339,
351
]
],
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"db_name": "UMLS",
"db_id": "C0030326"
}
]
},
{
"id": "DerHautarzt.00510513.eng.abstr-s4-t1",
"type": "umlsterm",
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"old"
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374,
377
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"db_name": "UMLS",
"db_id": "C0331059"
}
]
},
{
"id": "DerHautarzt.00510513.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"patient"
],
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[
378,
385
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],
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"db_name": "UMLS",
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},
{
"id": "DerHautarzt.00510513.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"history"
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404,
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"db_name": "UMLS",
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]
},
{
"id": "DerHautarzt.00510513.eng.abstr-s5-t1",
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"diagnosis"
],
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455,
464
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]
},
{
"id": "DerHautarzt.00510513.eng.abstr-s5-t2",
"type": "umlsterm",
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"T-cell"
],
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[
481,
487
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],
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"db_id": "C0039194"
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},
{
"id": "DerHautarzt.00510513.eng.abstr-s5-t3",
"type": "umlsterm",
"text": [
"lymphoma"
],
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[
488,
496
]
],
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{
"db_name": "UMLS",
"db_id": "C0024299"
}
]
},
{
"id": "DerHautarzt.00510513.eng.abstr-s5-t4",
"type": "umlsterm",
"text": [
"T-cell lymphoma"
],
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[
481,
496
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0079772"
}
]
},
{
"id": "DerHautarzt.00510513.eng.abstr-s6-t1",
"type": "umlsterm",
"text": [
"Chemotherapy"
],
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[
570,
582
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0013216"
},
{
"db_name": "UMLS",
"db_id": "C0013217"
}
]
},
{
"id": "DerHautarzt.00510513.eng.abstr-s7-t1",
"type": "umlsterm",
"text": [
"diagnosis"
],
"offsets": [
[
708,
717
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011900"
},
{
"db_name": "UMLS",
"db_id": "C0348026"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.00510513.eng.abstr-s1-r1-t1.2-t5.1",
"type": "degree_of",
"arg1_id": "DerHautarzt.00510513.eng.abstr-s7-t1",
"arg2_id": "DerHautarzt.00510513.eng.abstr-s3-t5",
"normalized": []
},
{
"id": "DerHautarzt.00510513.eng.abstr-s1-r2-t1.2-t7.1",
"type": "affects",
"arg1_id": "DerHautarzt.00510513.eng.abstr-s7-t1",
"arg2_id": "DerHautarzt.00510513.eng.abstr-s1-t7",
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},
{
"id": "DerHautarzt.00510513.eng.abstr-s1-r3-t2.1-t7.1",
"type": "location_of",
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"arg2_id": "DerHautarzt.00510513.eng.abstr-s1-t7",
"normalized": []
},
{
"id": "DerHautarzt.00510513.eng.abstr-s1-r4-t1.2-t8.1",
"type": "diagnoses",
"arg1_id": "DerHautarzt.00510513.eng.abstr-s7-t1",
"arg2_id": "DerHautarzt.00510513.eng.abstr-s1-t8",
"normalized": []
},
{
"id": "DerHautarzt.00510513.eng.abstr-s1-r5-t2.1-t6.1",
"type": "location_of",
"arg1_id": "DerHautarzt.00510513.eng.abstr-s5-t2",
"arg2_id": "DerHautarzt.00510513.eng.abstr-s1-t6",
"normalized": []
},
{
"id": "DerHautarzt.00510513.eng.abstr-s1-r6-t1.2-t8.1",
"type": "degree_of",
"arg1_id": "DerHautarzt.00510513.eng.abstr-s7-t1",
"arg2_id": "DerHautarzt.00510513.eng.abstr-s1-t8",
"normalized": []
},
{
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DerHautarzt.00510519.eng.abstr
|
DerHautarzt.00510519.eng.abstr
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"Pyoderma gangrenosum was first described in 1930 by Brunsting , Goeckermann and O ' Leary . Nevertheless we found some illustrations in an atlas on dermatology , published by Marie-Nicolas Devergie in the first half of the 19th century , which appear to be pyoderma gangrenosum . In addition to discussions of typical syphilitic affections of the skin , Devergie's \" Clinique de la Maladie Syphilitique \" includes illustrations of gangrenous ulcers , which appeared unexpectedly after local and systemic therapy with mercury . Devergie interpreted those enlarging ulcers as a side effect of mercury therapy . Thus we were able to find evidence of pyoderma gangrenosum more than 100 years before first description in 1930. The etiology of this clinical picture is still unsettled . The favorite postulate has been a bacterial genesis which was the subject of numerous publications until the 1960s ."
],
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] |
DerHautarzt.00510561.eng.abstr
|
DerHautarzt.00510561.eng.abstr
|
[
{
"id": "DerHautarzt.00510561.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Malignant melanoma is the most important differential diagnosis in both clinical and histologic examination of melanocytic nevi . UV exposure with an erythemagenic dose and mechanical irritation of melanocytic nevi are able to induce reversible morphologic changes which simulate malignant melanoma . These changes are associated with an increased expression of HMB-45 antigen . In addition , an increased proliferation and repair activity is observed after UV exposure . The increased number of melanocytes located in suprabasal layers of the epidermis is accompanied by a change in keratinocyte adhesion molecule expression . The UV light is also able to influence the adhesive properties of melanocytes in vitro . Therefore , both keratinocyte-derived factors and direct influence of UV on the melanocyte system are probably responsible for the morphologic changes . While these exogenously evoked changes are reversible , the potential biologic relevance - especially a possible role in the initiation of the carcinogenesis cascade - reguires clarification ."
],
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0,
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]
]
}
] |
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{
"id": "DerHautarzt.00510561.eng.abstr-s2-t2",
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"nevi"
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"id": "DerHautarzt.00510561.eng.abstr-s2-t5",
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{
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{
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{
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[] |
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DerHautarzt.00510575.eng.abstr
|
DerHautarzt.00510575.eng.abstr
|
[
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"id": "DerHautarzt.00510575.eng.abstr-passage-0",
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"text": [
"Background and objective . Shave excision of nevi is a technique still under debate . Speed , simplicity , and the fact that it provides excised material for histologic examination are contrasted with the lack of excision margins and a higher rate of nevus recurrences . In this study , the pros and cons of shave excision were evaluated ."
],
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0,
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]
}
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] |
[] |
[] |
[
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DerHautarzt.00510581.eng.abstr
|
DerHautarzt.00510581.eng.abstr
|
[
{
"id": "DerHautarzt.00510581.eng.abstr-passage-0",
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{
"db_name": "UMLS",
"db_id": "C0039798"
}
]
}
] |
[] |
[] |
[
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DerHautarzt.00510590.eng.abstr
|
DerHautarzt.00510590.eng.abstr
|
[
{
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],
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[
0,
244
]
]
}
] |
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}
]
}
] |
[] |
[] |
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] |
DerHautarzt.00510593.eng.abstr
|
DerHautarzt.00510593.eng.abstr
|
[
{
"id": "DerHautarzt.00510593.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Classic variants of cutaneous borreliosis are erythema chronicum migrans ( ECM ) , lymphadenosis benigna cutis ( LBC ) and acrodermatitis chronica atrophicans ( ACA ) . Other dermatoses have been reported in the literature as possibly linked to borreliosis . A 59-year old female patient was seen in the late phases of cutaneous borreliosis with histologically confirmed ACA . In addition , prominent livedo racemosa was seen on the legs , also showing tissue changes similar to those of ACA . Borrelia burgdorferi infection was serologically confirmed by the presence of anti-IgM and anti-IgG antibodies . The clinical spectrum of late cutaneous borreliosis should be enlarged to include livedo racemosa ."
],
"offsets": [
[
0,
706
]
]
}
] |
[
{
"id": "DerHautarzt.00510593.eng.abstr-s1-t1",
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"borreliosis"
],
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[
30,
41
]
],
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"db_id": "C0751995"
}
]
},
{
"id": "DerHautarzt.00510593.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"erythema"
],
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[
46,
54
]
],
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{
"db_name": "UMLS",
"db_id": "C0041834"
}
]
},
{
"id": "DerHautarzt.00510593.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"ECM"
],
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[
75,
78
]
],
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{
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"db_id": "C0015350"
}
]
},
{
"id": "DerHautarzt.00510593.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"acrodermatitis"
],
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[
123,
137
]
],
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{
"db_name": "UMLS",
"db_id": "C0001197"
}
]
},
{
"id": "DerHautarzt.00510593.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"erythema chronicum migrans"
],
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[
46,
72
]
],
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{
"db_name": "UMLS",
"db_id": "C0014740"
}
]
},
{
"id": "DerHautarzt.00510593.eng.abstr-s2-t1",
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"dermatoses"
],
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175,
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]
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{
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"db_id": "C0037274"
}
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},
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"literature"
],
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]
},
{
"id": "DerHautarzt.00510593.eng.abstr-s2-t3",
"type": "umlsterm",
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}
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},
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"id": "DerHautarzt.00510593.eng.abstr-s3-t1",
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"old"
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269,
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]
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{
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}
]
},
{
"id": "DerHautarzt.00510593.eng.abstr-s3-t2",
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"text": [
"female"
],
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273,
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]
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"db_id": "C0086287"
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}
]
},
{
"id": "DerHautarzt.00510593.eng.abstr-s3-t3",
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"patient"
],
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280,
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"id": "DerHautarzt.00510593.eng.abstr-s3-t4",
"type": "umlsterm",
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"borreliosis"
],
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329,
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]
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}
]
},
{
"id": "DerHautarzt.00510593.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"legs"
],
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433,
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]
],
"normalized": [
{
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}
]
},
{
"id": "DerHautarzt.00510593.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"tissue"
],
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[
453,
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]
],
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"db_id": "C0040300"
}
]
},
{
"id": "DerHautarzt.00510593.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"livedo racemosa"
],
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401,
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]
],
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]
},
{
"id": "DerHautarzt.00510593.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"Borrelia"
],
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494,
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],
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},
{
"id": "DerHautarzt.00510593.eng.abstr-s5-t2",
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"infection"
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},
{
"id": "DerHautarzt.00510593.eng.abstr-s5-t3",
"type": "umlsterm",
"text": [
"anti-IgM"
],
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]
],
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},
{
"id": "DerHautarzt.00510593.eng.abstr-s5-t4",
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"anti-IgG"
],
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"id": "DerHautarzt.00510593.eng.abstr-s5-t6",
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"Borrelia burgdorferi"
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]
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},
{
"id": "DerHautarzt.00510593.eng.abstr-s6-t2",
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]
}
] |
[] |
[] |
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},
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},
{
"id": "DerHautarzt.00510593.eng.abstr-s5-r4-t2.1-t6.1",
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},
{
"id": "DerHautarzt.00510593.eng.abstr-s5-r5-t1.1-t3.1",
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"id": "DerHautarzt.00510593.eng.abstr-s5-r7-t6.1-t3.1",
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{
"id": "DerHautarzt.00510593.eng.abstr-s5-r11-t6.1-t2.1",
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{
"id": "DerHautarzt.00510593.eng.abstr-s6-r1-t1.1-t2.1",
"type": "location_of",
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"arg2_id": "DerHautarzt.00510593.eng.abstr-s6-t2",
"normalized": []
}
] |
DerHautarzt.00510597.eng.abstr
|
DerHautarzt.00510597.eng.abstr
|
[
{
"id": "DerHautarzt.00510597.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The non-Native American type of actinic prurigo belongs to the group of rare idiopathic photodermatoses and therefore is often diagnosed with delay . The typical clinical and epidemiological features of actinic prurigo are described in a 10 year old girl . Detailed phototesting showed urticarial early onset and prurigo-like late onset reactions towards long-wave UVA . Repetitive photoprovocation with UVB induced delayed development of papules . HLA typing showed the typical association with HLA-DR4, in particular DRB1*0407. Treatment is usually extremely difficult and unrewarding . In this patient , the course was considerably improved by more intense physical photoprotection ."
],
"offsets": [
[
0,
686
]
]
}
] |
[
{
"id": "DerHautarzt.00510597.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"non-Native"
],
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4,
14
]
],
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{
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"db_id": "C0079891"
}
]
},
{
"id": "DerHautarzt.00510597.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"prurigo"
],
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[
40,
47
]
],
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"db_name": "UMLS",
"db_id": "C0033771"
}
]
},
{
"id": "DerHautarzt.00510597.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"prurigo"
],
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[
211,
218
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0033771"
}
]
},
{
"id": "DerHautarzt.00510597.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"old"
],
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[
246,
249
]
],
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{
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"db_id": "C0331059"
}
]
},
{
"id": "DerHautarzt.00510597.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"prurigo-like"
],
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[
313,
325
]
],
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{
"db_name": "UMLS",
"db_id": "C0033771"
}
]
},
{
"id": "DerHautarzt.00510597.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"development"
],
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[
424,
435
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0243107"
},
{
"db_name": "UMLS",
"db_id": "C0020119"
}
]
},
{
"id": "DerHautarzt.00510597.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"HLA"
],
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[
449,
452
]
],
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"db_id": "C0019721"
}
]
},
{
"id": "DerHautarzt.00510597.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"association"
],
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[
479,
490
]
],
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{
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"db_id": "C0004083"
}
]
},
{
"id": "DerHautarzt.00510597.eng.abstr-s5-t3",
"type": "umlsterm",
"text": [
"Treatment"
],
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[
530,
539
]
],
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"db_id": "C0087111"
},
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"db_id": "C0039798"
}
]
},
{
"id": "DerHautarzt.00510597.eng.abstr-s5-t4",
"type": "umlsterm",
"text": [
"HLA typing"
],
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[
449,
459
]
],
"normalized": [
{
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"db_id": "C0242318"
}
]
},
{
"id": "DerHautarzt.00510597.eng.abstr-s6-t1",
"type": "umlsterm",
"text": [
"patient"
],
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[
597,
604
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.00510597.eng.abstr-s2-r1-t1.1-t2.1",
"type": "affects",
"arg1_id": "DerHautarzt.00510597.eng.abstr-s6-t1",
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"normalized": []
},
{
"id": "DerHautarzt.00510597.eng.abstr-s5-r1-t3.2-t2.1",
"type": "result_of",
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},
{
"id": "DerHautarzt.00510597.eng.abstr-s5-r2-t4.1-t1.1",
"type": "analyzes",
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"arg2_id": "DerHautarzt.00510597.eng.abstr-s6-t1",
"normalized": []
},
{
"id": "DerHautarzt.00510597.eng.abstr-s5-r3-t1.1-t2.1",
"type": "affects",
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"arg2_id": "DerHautarzt.00510597.eng.abstr-s5-t2",
"normalized": []
},
{
"id": "DerHautarzt.00510597.eng.abstr-s5-r4-t2.1-t1.1",
"type": "produces",
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"arg2_id": "DerHautarzt.00510597.eng.abstr-s6-t1",
"normalized": []
},
{
"id": "DerHautarzt.00510597.eng.abstr-s5-r5-t4.1-t2.1",
"type": "assesses_effect_of",
"arg1_id": "DerHautarzt.00510597.eng.abstr-s5-t4",
"arg2_id": "DerHautarzt.00510597.eng.abstr-s5-t2",
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},
{
"id": "DerHautarzt.00510597.eng.abstr-s5-r6-t4.1-t3.1",
"type": "method_of",
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"arg2_id": "DerHautarzt.00510597.eng.abstr-s5-t3",
"normalized": []
},
{
"id": "DerHautarzt.00510597.eng.abstr-s5-r7-t3.1-t2.1",
"type": "affects",
"arg1_id": "DerHautarzt.00510597.eng.abstr-s5-t3",
"arg2_id": "DerHautarzt.00510597.eng.abstr-s5-t2",
"normalized": []
}
] |
DerHautarzt.00510612.eng.abstr
|
DerHautarzt.00510612.eng.abstr
|
[
{
"id": "DerHautarzt.00510612.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 53 year old female patient developed a keratoacanthoma , present on the left side of her nose for two months . After repeated unsuccessful trials with cryotherapy , she was treated with intralesional injection of methotrexate performed twice with a weekly internal . This led to complete resolution within 5 weeks . Although controlled studies on the effect of methotrexate in keratoacanthoma are not available , the rapid regression and the good cosmetic result suggest that this therapy may play a beneficial role in treating these lesions especially in problem locations ."
],
"offsets": [
[
0,
577
]
]
}
] |
[
{
"id": "DerHautarzt.00510612.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"old"
],
"offsets": [
[
10,
13
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0331059"
}
]
},
{
"id": "DerHautarzt.00510612.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"female"
],
"offsets": [
[
14,
20
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0086287"
},
{
"db_name": "UMLS",
"db_id": "C0015780"
}
]
},
{
"id": "DerHautarzt.00510612.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"patient"
],
"offsets": [
[
21,
28
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.00510612.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"keratoacanthoma"
],
"offsets": [
[
41,
56
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0022572"
}
]
},
{
"id": "DerHautarzt.00510612.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"nose"
],
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[
91,
95
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0028429"
}
]
},
{
"id": "DerHautarzt.00510612.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"cryotherapy"
],
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[
153,
164
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0010412"
},
{
"db_name": "UMLS",
"db_id": "C0010408"
}
]
},
{
"id": "DerHautarzt.00510612.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"injection"
],
"offsets": [
[
202,
211
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0021485"
}
]
},
{
"id": "DerHautarzt.00510612.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"methotrexate"
],
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[
215,
227
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0025646"
}
]
},
{
"id": "DerHautarzt.00510612.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"intralesional injection"
],
"offsets": [
[
188,
211
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0021490"
}
]
},
{
"id": "DerHautarzt.00510612.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"methotrexate"
],
"offsets": [
[
363,
375
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0025646"
}
]
},
{
"id": "DerHautarzt.00510612.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"keratoacanthoma"
],
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[
379,
394
]
],
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{
"db_name": "UMLS",
"db_id": "C0022572"
}
]
},
{
"id": "DerHautarzt.00510612.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"regression"
],
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[
425,
435
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0034979"
}
]
},
{
"id": "DerHautarzt.00510612.eng.abstr-s4-t4",
"type": "umlsterm",
"text": [
"cosmetic"
],
"offsets": [
[
449,
457
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0010164"
}
]
},
{
"id": "DerHautarzt.00510612.eng.abstr-s4-t5",
"type": "umlsterm",
"text": [
"therapy"
],
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[
483,
490
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0087111"
},
{
"db_name": "UMLS",
"db_id": "C0039798"
}
]
},
{
"id": "DerHautarzt.00510612.eng.abstr-s4-t6",
"type": "umlsterm",
"text": [
"role"
],
"offsets": [
[
513,
517
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0035820"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.00510612.eng.abstr-s1-r1-t4.1-t2.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.00510612.eng.abstr-s4-t4",
"arg2_id": "DerHautarzt.00510612.eng.abstr-s4-t2",
"normalized": []
},
{
"id": "DerHautarzt.00510612.eng.abstr-s1-r2-t4.1-t1.1",
"type": "occurs_in",
"arg1_id": "DerHautarzt.00510612.eng.abstr-s4-t4",
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] |
DerHautarzt.00510637.eng.abstr
|
DerHautarzt.00510637.eng.abstr
|
[
{
"id": "DerHautarzt.00510637.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Bullous pemphigoid ( BP ) is a subepidermal blistering autoimmune disease of the elderly . Autoantibodies are directed against two hemidesmosomal proteins , designated BP180 and BP230. While BP230 localizes intracellularly and associates with the hemidesmosomal plaque , BP180 is a transmembrane glycoprotein with an extracellular domain consisting of approximately 1000 amino acids . The non-collagenous ( NC ) 16A domain , that encompasses 76 amino acids and localizes directly adjacent to the transmembrane region , has been identified as an immunodominant region of the BP180 ectodomain . In the majoroty of BP sera , circulating antibodies to BP180NC16A are detected ; their serum levels correlate with disease activity . Neonatal mice that are injected with rabbit anti-murine BP180 antibodies develop a BP-like subepidermal blistering disease demonstraiting the biological importance of antibodies to BP180. The pathogenetically relevant site on murine BP180 corresponds to a stretch of the NC16A domain on human BP180. In contrast to pemphigus , in BP , autoantibodies alone are not sufficient to induce blisters . In addition , complement activation , the infiltration of inflammatory cells and the release of proteases and various inflammatory mediators , including cytokines , are essential for lesion formation . In this review , we give an up-date on the pathogenesis of BP ."
],
"offsets": [
[
0,
1388
]
]
}
] |
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] |
DerHautarzt.00510646.eng.abstr
|
DerHautarzt.00510646.eng.abstr
|
[
{
"id": "DerHautarzt.00510646.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The immunosuppressive macrolides are a novel class of antiinflammatory substances , which could supplant glucocorticosteroids for the topical treatment of some chronic inflammatory skin diseases . Cyclosporine A ( CyA ) , well known from transplantation medicine for years , is licensed in Germany for oral treatment of psoriasis and atopic dermatitis but is not suitable for topical therapy . Tacrolimus ( FK506) penetrates the inflamed epidermis and is regarded as the key immunosuppressive macrolide . Clinical trials have demonstrated the efficacy of FK506 ointment for atopic dermatitis , many case reports have been published regarding other inflammatory skin diseases . The ascomycin derivative ASM 981 has many of the properties of FK506 but less data is available at present . Sirolimus ( Rapamycin ) is structurally related to FK506 but has other biological effects since its molecular actions involve different biochemical pathways . A review of the biochemical and cellular properties , mode of action , therapeutic efficacy and unwanted side effects , as well as data from clinical trials and status of licensing , is given for the respective drugs ."
],
"offsets": [
[
0,
1163
]
]
}
] |
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"id": "DerHautarzt.00510646.eng.abstr-s6-r9-t1.1-t4.1",
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},
{
"id": "DerHautarzt.00510646.eng.abstr-s7-r1-t5.1-t3.1",
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},
{
"id": "DerHautarzt.00510646.eng.abstr-s7-r2-t1.1-t3.1",
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"normalized": []
},
{
"id": "DerHautarzt.00510646.eng.abstr-s7-r3-t3.1-t5.1",
"type": "diagnoses",
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},
{
"id": "DerHautarzt.00510646.eng.abstr-s7-r4-t3.1-t5.1",
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"arg2_id": "DerHautarzt.00510646.eng.abstr-s7-t5",
"normalized": []
},
{
"id": "DerHautarzt.00510646.eng.abstr-s7-r5-t3.1-t5.1",
"type": "treats",
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"arg2_id": "DerHautarzt.00510646.eng.abstr-s7-t5",
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},
{
"id": "DerHautarzt.00510646.eng.abstr-s7-r6-t5.1-t3.1",
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},
{
"id": "DerHautarzt.00510646.eng.abstr-s7-r7-t5.1-t1.1",
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"arg2_id": "DerHautarzt.00510646.eng.abstr-s7-t1",
"normalized": []
},
{
"id": "DerHautarzt.00510646.eng.abstr-s7-r8-t1.1-t5.1",
"type": "associated_with",
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"normalized": []
},
{
"id": "DerHautarzt.00510646.eng.abstr-s7-r9-t5.1-t3.1",
"type": "measures",
"arg1_id": "DerHautarzt.00510646.eng.abstr-s7-t5",
"arg2_id": "DerHautarzt.00510646.eng.abstr-s7-t3",
"normalized": []
}
] |
DerHautarzt.00510661.eng.abstr
|
DerHautarzt.00510661.eng.abstr
|
[
{
"id": "DerHautarzt.00510661.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Background and Objective . Lipomas should be included in the differential diagnosis of tumors located on the forehead . They require a different operative plan ."
],
"offsets": [
[
0,
161
]
]
}
] |
[
{
"id": "DerHautarzt.00510661.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"Objective"
],
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[
15,
24
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018017"
}
]
},
{
"id": "DerHautarzt.00510661.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"Lipomas"
],
"offsets": [
[
27,
34
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0023798"
}
]
},
{
"id": "DerHautarzt.00510661.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"diagnosis"
],
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[
74,
83
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011900"
},
{
"db_name": "UMLS",
"db_id": "C0348026"
}
]
},
{
"id": "DerHautarzt.00510661.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"tumors"
],
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87,
93
]
],
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"db_id": "C0027651"
}
]
},
{
"id": "DerHautarzt.00510661.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"forehead"
],
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109,
117
]
],
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"db_id": "C0016540"
}
]
},
{
"id": "DerHautarzt.00510661.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"differential diagnosis"
],
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[
61,
83
]
],
"normalized": [
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"db_name": "UMLS",
"db_id": "C0220820"
},
{
"db_name": "UMLS",
"db_id": "C0011906"
}
]
},
{
"id": "DerHautarzt.00510661.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"plan"
],
"offsets": [
[
155,
159
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0032074"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.00510661.eng.abstr-s2-r2-t4.1-t1.1",
"type": "location_of",
"arg1_id": "DerHautarzt.00510661.eng.abstr-s2-t4",
"arg2_id": "DerHautarzt.00510661.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "DerHautarzt.00510661.eng.abstr-s2-r3-t4.1-t2.2",
"type": "location_of",
"arg1_id": "DerHautarzt.00510661.eng.abstr-s2-t4",
"arg2_id": "DerHautarzt.00510661.eng.abstr-s2-t2",
"normalized": []
},
{
"id": "DerHautarzt.00510661.eng.abstr-s2-r5-t5.1-t2.2",
"type": "associated_with",
"arg1_id": "DerHautarzt.00510661.eng.abstr-s2-t5",
"arg2_id": "DerHautarzt.00510661.eng.abstr-s2-t2",
"normalized": []
},
{
"id": "DerHautarzt.00510661.eng.abstr-s2-r6-t1.1-t5.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.00510661.eng.abstr-s3-t1",
"arg2_id": "DerHautarzt.00510661.eng.abstr-s2-t5",
"normalized": []
},
{
"id": "DerHautarzt.00510661.eng.abstr-s2-r7-t2.1-t1.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.00510661.eng.abstr-s2-t2",
"arg2_id": "DerHautarzt.00510661.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "DerHautarzt.00510661.eng.abstr-s2-r8-t4.1-t5.1",
"type": "location_of",
"arg1_id": "DerHautarzt.00510661.eng.abstr-s2-t4",
"arg2_id": "DerHautarzt.00510661.eng.abstr-s2-t5",
"normalized": []
},
{
"id": "DerHautarzt.00510661.eng.abstr-s2-r9-t2.2-t5.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.00510661.eng.abstr-s2-t2",
"arg2_id": "DerHautarzt.00510661.eng.abstr-s2-t5",
"normalized": []
},
{
"id": "DerHautarzt.00510661.eng.abstr-s2-r10-t5.1-t1.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.00510661.eng.abstr-s2-t5",
"arg2_id": "DerHautarzt.00510661.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "DerHautarzt.00510661.eng.abstr-s2-r11-t4.1-t2.1",
"type": "location_of",
"arg1_id": "DerHautarzt.00510661.eng.abstr-s2-t4",
"arg2_id": "DerHautarzt.00510661.eng.abstr-s2-t2",
"normalized": []
},
{
"id": "DerHautarzt.00510661.eng.abstr-s2-r12-t1.1-t2.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.00510661.eng.abstr-s3-t1",
"arg2_id": "DerHautarzt.00510661.eng.abstr-s2-t2",
"normalized": []
}
] |
DerHautarzt.00510666.eng.abstr
|
DerHautarzt.00510666.eng.abstr
|
[
{
"id": "DerHautarzt.00510666.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Background and Objective . Because of the increasing resistance of Neisseria gonorrhoeae , we studied the actual resistance of isolats in Berlin ."
],
"offsets": [
[
0,
146
]
]
}
] |
[
{
"id": "DerHautarzt.00510666.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"Objective"
],
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[
15,
24
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018017"
}
]
},
{
"id": "DerHautarzt.00510666.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"Neisseria"
],
"offsets": [
[
67,
76
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027571"
}
]
},
{
"id": "DerHautarzt.00510666.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"Berlin"
],
"offsets": [
[
138,
144
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0005125"
}
]
},
{
"id": "DerHautarzt.00510666.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"Neisseria gonorrhoeae"
],
"offsets": [
[
67,
88
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027573"
}
]
}
] |
[] |
[] |
[] |
DerHautarzt.00510670.eng.abstr
|
DerHautarzt.00510670.eng.abstr
|
[
{
"id": "DerHautarzt.00510670.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Background and Objective . Pemphigus is a rare intraepidermal autoimmune bullous disease . Two major variants , pemphigus vulgaris ( PV ) and pemphigus foliaceus ( PF ) , are distinguished . The aim of this study was to document the clinical and immunpathological findings in all pemphigus patients who were diagnosed in the Department of Dermatology at the University of Wuerzburg over the past 10 years ."
],
"offsets": [
[
0,
406
]
]
}
] |
[
{
"id": "DerHautarzt.00510670.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"Objective"
],
"offsets": [
[
15,
24
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018017"
}
]
},
{
"id": "DerHautarzt.00510670.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"Pemphigus"
],
"offsets": [
[
27,
36
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030807"
}
]
},
{
"id": "DerHautarzt.00510670.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"disease"
],
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[
81,
88
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0012634"
}
]
},
{
"id": "DerHautarzt.00510670.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"pemphigus"
],
"offsets": [
[
112,
121
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030807"
}
]
},
{
"id": "DerHautarzt.00510670.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"pemphigus"
],
"offsets": [
[
142,
151
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030807"
}
]
},
{
"id": "DerHautarzt.00510670.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"pemphigus vulgaris"
],
"offsets": [
[
112,
130
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030809"
}
]
},
{
"id": "DerHautarzt.00510670.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"aim"
],
"offsets": [
[
195,
198
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0108800"
}
]
},
{
"id": "DerHautarzt.00510670.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"findings"
],
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[
264,
272
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0243095"
}
]
},
{
"id": "DerHautarzt.00510670.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"pemphigus"
],
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[
280,
289
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030807"
}
]
},
{
"id": "DerHautarzt.00510670.eng.abstr-s4-t4",
"type": "umlsterm",
"text": [
"patients"
],
"offsets": [
[
290,
298
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.00510670.eng.abstr-s4-t5",
"type": "umlsterm",
"text": [
"Dermatology"
],
"offsets": [
[
339,
350
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011627"
}
]
},
{
"id": "DerHautarzt.00510670.eng.abstr-s4-t6",
"type": "umlsterm",
"text": [
"University"
],
"offsets": [
[
358,
368
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0041740"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.00510670.eng.abstr-s4-r1-t4.1-t5.1",
"type": "issue_in",
"arg1_id": "DerHautarzt.00510670.eng.abstr-s4-t4",
"arg2_id": "DerHautarzt.00510670.eng.abstr-s4-t5",
"normalized": []
},
{
"id": "DerHautarzt.00510670.eng.abstr-s4-r2-t1.1-t5.1",
"type": "issue_in",
"arg1_id": "DerHautarzt.00510670.eng.abstr-s4-t1",
"arg2_id": "DerHautarzt.00510670.eng.abstr-s4-t5",
"normalized": []
},
{
"id": "DerHautarzt.00510670.eng.abstr-s4-r3-t6.1-t1.1",
"type": "causes",
"arg1_id": "DerHautarzt.00510670.eng.abstr-s4-t6",
"arg2_id": "DerHautarzt.00510670.eng.abstr-s4-t1",
"normalized": []
},
{
"id": "DerHautarzt.00510670.eng.abstr-s4-r4-t1.1-t4.1",
"type": "occurs_in",
"arg1_id": "DerHautarzt.00510670.eng.abstr-s4-t1",
"arg2_id": "DerHautarzt.00510670.eng.abstr-s4-t4",
"normalized": []
},
{
"id": "DerHautarzt.00510670.eng.abstr-s4-r5-t4.1-t6.1",
"type": "uses",
"arg1_id": "DerHautarzt.00510670.eng.abstr-s4-t4",
"arg2_id": "DerHautarzt.00510670.eng.abstr-s4-t6",
"normalized": []
},
{
"id": "DerHautarzt.00510670.eng.abstr-s4-r6-t2.1-t5.1",
"type": "issue_in",
"arg1_id": "DerHautarzt.00510670.eng.abstr-s4-t2",
"arg2_id": "DerHautarzt.00510670.eng.abstr-s4-t5",
"normalized": []
},
{
"id": "DerHautarzt.00510670.eng.abstr-s4-r7-t2.1-t1.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.00510670.eng.abstr-s4-t2",
"arg2_id": "DerHautarzt.00510670.eng.abstr-s4-t1",
"normalized": []
},
{
"id": "DerHautarzt.00510670.eng.abstr-s4-r8-t6.1-t5.1",
"type": "issue_in",
"arg1_id": "DerHautarzt.00510670.eng.abstr-s4-t6",
"arg2_id": "DerHautarzt.00510670.eng.abstr-s4-t5",
"normalized": []
},
{
"id": "DerHautarzt.00510670.eng.abstr-s4-r9-t1.1-t2.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.00510670.eng.abstr-s4-t1",
"arg2_id": "DerHautarzt.00510670.eng.abstr-s4-t2",
"normalized": []
}
] |
DerHautarzt.00510678.eng.abstr
|
DerHautarzt.00510678.eng.abstr
|
[
{
"id": "DerHautarzt.00510678.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Drug-induced leucocytoclastic vasculitis is clinically characterised by inflammation of small vessels and skin alterations , typically palpable purpura . Often the vasculitis is accompanied by fever , myalgia and malaise . All ages and sexes are equally affected . Besides the mentioned clinical features it may also present as macules , papules , vesicules , bullae , subcutaneous nodules or intermittent or chronic urticarial eruptions . Other organ systems may be affected . The patient's history is helpful in identifying the etiologic agent . If a drug is suspected as etiologic agent , a positive lymphocyte transformation test ( LTT ) supports the hypothesis . A 55 year old femal patient developed an ANA and anti-histone antibody positive leukocytoclastic vasculitis with probable concomittant renal involvement after three weeks treatment with ibuprofen . Three months after discontinuation of the medication , the patient is without complaints and has a normal urine sedimentation and normalized immunoautoantibodies ."
],
"offsets": [
[
0,
1029
]
]
}
] |
[
{
"id": "DerHautarzt.00510678.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"vasculitis"
],
"offsets": [
[
30,
40
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0042384"
}
]
},
{
"id": "DerHautarzt.00510678.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"inflammation"
],
"offsets": [
[
72,
84
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0021368"
}
]
},
{
"id": "DerHautarzt.00510678.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"vessels"
],
"offsets": [
[
94,
101
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0005847"
},
{
"db_name": "UMLS",
"db_id": "C0148346"
}
]
},
{
"id": "DerHautarzt.00510678.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"skin"
],
"offsets": [
[
106,
110
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.00510678.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"purpura"
],
"offsets": [
[
144,
151
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0034150"
}
]
},
{
"id": "DerHautarzt.00510678.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"leucocytoclastic vasculitis"
],
"offsets": [
[
13,
40
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0151436"
}
]
},
{
"id": "DerHautarzt.00510678.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"vasculitis"
],
"offsets": [
[
164,
174
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0042384"
}
]
},
{
"id": "DerHautarzt.00510678.eng.abstr-s2-t2",
"type": "umlsterm",
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] |
DerHautarzt.00510682.eng.abstr
|
DerHautarzt.00510682.eng.abstr
|
[
{
"id": "DerHautarzt.00510682.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A myxoid cyst on the dorsum of the left index finger is presented . A connection of this pseudocyst to the underlying joint was shown by means of magnetic resonance imaging . Surgically the connecting tract to the distal interphalangeal joint was easily demonstrated and histologically a ductal structure was focally seen by means of serial sections . These structures also suggest such a connection . These findings confirm the view that this pseudocyst can be interpreted as a ganglion . Therapeutically complete excision with careful tying off of the channel to the joint appears to be the best method to avoid recurrence . The injection of sclerosing agents , a conservative treatment modality proposed by some authors , may be problematic in the light of the pathogenesis discussed here ; however dammage to the finger joint has not been so far observed ."
],
"offsets": [
[
0,
860
]
]
}
] |
[
{
"id": "DerHautarzt.00510682.eng.abstr-s1-t1",
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"cyst"
],
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9,
13
]
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]
},
{
"id": "DerHautarzt.00510682.eng.abstr-s1-t2",
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"text": [
"dorsum"
],
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21,
27
]
],
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},
{
"id": "DerHautarzt.00510682.eng.abstr-s1-t3",
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"text": [
"index"
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[
40,
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]
],
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},
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"db_id": "C0918012"
}
]
},
{
"id": "DerHautarzt.00510682.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"finger"
],
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]
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}
]
},
{
"id": "DerHautarzt.00510682.eng.abstr-s1-t5",
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"text": [
"myxoid cyst"
],
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[
2,
13
]
],
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},
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"id": "DerHautarzt.00510682.eng.abstr-s2-t1",
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"joint"
],
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[
118,
123
]
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"db_id": "C0022417"
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},
{
"id": "DerHautarzt.00510682.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"magnetic"
],
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[
146,
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]
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}
]
},
{
"id": "DerHautarzt.00510682.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"resonance"
],
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[
155,
164
]
],
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"db_id": "C0459800"
}
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},
{
"id": "DerHautarzt.00510682.eng.abstr-s2-t4",
"type": "umlsterm",
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"imaging"
],
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[
165,
172
]
],
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"db_id": "C0011923"
}
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},
{
"id": "DerHautarzt.00510682.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"magnetic resonance"
],
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146,
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]
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{
"id": "DerHautarzt.00510682.eng.abstr-s2-t6",
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"magnetic resonance imaging"
],
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},
{
"id": "DerHautarzt.00510682.eng.abstr-s3-t1",
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"joint"
],
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237,
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]
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]
},
{
"id": "DerHautarzt.00510682.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"serial"
],
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334,
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]
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},
{
"id": "DerHautarzt.00510682.eng.abstr-s5-t1",
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],
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}
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},
{
"id": "DerHautarzt.00510682.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"ganglion"
],
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479,
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]
],
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{
"id": "DerHautarzt.00510682.eng.abstr-s6-t1",
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},
{
"id": "DerHautarzt.00510682.eng.abstr-s6-t2",
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},
{
"id": "DerHautarzt.00510682.eng.abstr-s6-t3",
"type": "umlsterm",
"text": [
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],
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},
{
"id": "DerHautarzt.00510682.eng.abstr-s7-t1",
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"injection"
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]
},
{
"id": "DerHautarzt.00510682.eng.abstr-s7-t3",
"type": "umlsterm",
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},
{
"id": "DerHautarzt.00510682.eng.abstr-s7-t4",
"type": "umlsterm",
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"pathogenesis"
],
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{
"id": "DerHautarzt.00510682.eng.abstr-s7-t5",
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"finger"
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"id": "DerHautarzt.00510682.eng.abstr-s7-t6",
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{
"id": "DerHautarzt.00510682.eng.abstr-s7-t7",
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]
}
] |
[] |
[] |
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DerHautarzt.00510685.eng.abstr
|
DerHautarzt.00510685.eng.abstr
|
[
{
"id": "DerHautarzt.00510685.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A fourteen years old girl showed the classic signs of acrocephalosyndactyly I : dysostosis craniofacialis with hypertelorism , exophthalmus , strabism , amblyopia and cleft palate as well as syndactyly of the fingers and toes . The feet showed on both side a 6 cm long horny band . Since the twelfth year of life , she had suffered from papulo-pustular acne with many comedomes . Her menstruation started one year later . Intellectual development was normal . At time of her birth , her father was 54 years old , and her mother 36 years old . Two elder siblings are healthy . The inheritance of acrocephalosyndactyly I is usually autosomal dominant , but sporadic cases are frequent ."
],
"offsets": [
[
0,
684
]
]
}
] |
[
{
"id": "DerHautarzt.00510685.eng.abstr-s1-t1",
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"old"
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]
],
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},
{
"id": "DerHautarzt.00510685.eng.abstr-s1-t2",
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"text": [
"signs"
],
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[
45,
50
]
],
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"db_id": "C0220912"
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},
{
"id": "DerHautarzt.00510685.eng.abstr-s1-t3",
"type": "umlsterm",
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"acrocephalosyndactyly"
],
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[
54,
75
]
],
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"db_id": "C0001193"
}
]
},
{
"id": "DerHautarzt.00510685.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"dysostosis"
],
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80,
90
]
],
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"db_id": "C0013393"
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]
},
{
"id": "DerHautarzt.00510685.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"hypertelorism"
],
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111,
124
]
],
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}
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},
{
"id": "DerHautarzt.00510685.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"amblyopia"
],
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153,
162
]
],
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{
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"db_id": "C0002418"
}
]
},
{
"id": "DerHautarzt.00510685.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"palate"
],
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[
173,
179
]
],
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"db_id": "C0700374"
}
]
},
{
"id": "DerHautarzt.00510685.eng.abstr-s1-t8",
"type": "umlsterm",
"text": [
"syndactyly"
],
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[
191,
201
]
],
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{
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"db_id": "C0039075"
}
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},
{
"id": "DerHautarzt.00510685.eng.abstr-s1-t9",
"type": "umlsterm",
"text": [
"fingers"
],
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[
209,
216
]
],
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{
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"db_id": "C0016129"
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]
},
{
"id": "DerHautarzt.00510685.eng.abstr-s1-t10",
"type": "umlsterm",
"text": [
"toes"
],
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[
221,
225
]
],
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{
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"db_id": "C0040357"
}
]
},
{
"id": "DerHautarzt.00510685.eng.abstr-s1-t11",
"type": "umlsterm",
"text": [
"cleft palate"
],
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[
167,
179
]
],
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{
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"db_id": "C0008925"
}
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},
{
"id": "DerHautarzt.00510685.eng.abstr-s2-t1",
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"text": [
"feet"
],
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[
232,
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]
],
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{
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"db_id": "C0016504"
}
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},
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"id": "DerHautarzt.00510685.eng.abstr-s3-t1",
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"life"
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]
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},
{
"id": "DerHautarzt.00510685.eng.abstr-s3-t2",
"type": "umlsterm",
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"acne"
],
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353,
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],
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},
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"id": "DerHautarzt.00510685.eng.abstr-s4-t1",
"type": "umlsterm",
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"menstruation"
],
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384,
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"id": "DerHautarzt.00510685.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"development"
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]
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"id": "DerHautarzt.00510685.eng.abstr-s6-t1",
"type": "umlsterm",
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"id": "DerHautarzt.00510685.eng.abstr-s6-t2",
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"id": "DerHautarzt.00510685.eng.abstr-s6-t3",
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"father"
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"id": "DerHautarzt.00510685.eng.abstr-s6-t4",
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"id": "DerHautarzt.00510685.eng.abstr-s6-t5",
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"mother"
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"id": "DerHautarzt.00510685.eng.abstr-s6-t6",
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{
"id": "DerHautarzt.00510685.eng.abstr-s7-t1",
"type": "umlsterm",
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"elder"
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"id": "DerHautarzt.00510685.eng.abstr-s7-t2",
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"id": "DerHautarzt.00510685.eng.abstr-s8-t1",
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"inheritance"
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{
"id": "DerHautarzt.00510685.eng.abstr-s8-t2",
"type": "umlsterm",
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] |
[] |
[] |
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DerHautarzt.00510729.eng.abstr
|
DerHautarzt.00510729.eng.abstr
|
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{
"id": "DerHautarzt.00510729.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Hair problems are attacked at the levels of information supply , trichological competence and evidence based medical treatment . The alopecias represent a major health care challenge , and the psychological significance of hair loss has only recently found appreciation in the medical community . They may pose a vexing problem for non-specialized physicians , who tend to trivialize such complaints , although the patient's perception of abnormality determines whether or not advice is sought . Perception of a hair problem is subject to sociocultural standards ; films and advertisements help determine the threshold for \" normality \" and what is \" healthy \" and \" beautiful \" , and the media provide an abundance of undiscriminating information with respect to hair care . Patients with hair problems frequently consult the hairdresser prior to the medical specialist . Thus additional areas of competence should be incorporated into the hairdresser's training qualifications . Besides manual , creative and psychological aptitudes , \" trichological competence \" relating to the recognition of most important hair disorders , recognition of personal limitations and cooperation with the medical specialist are required . To optimize the interaction between the physician , hairdressers and the media , more effective communication and public activities from the medical profession are desirable , with success depending on full identification of the set goals , qualification and adherance to the standards determined by the medical speciality ."
],
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0,
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]
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DerHautarzt.00510733.eng.abstr
|
DerHautarzt.00510733.eng.abstr
|
[
{
"id": "DerHautarzt.00510733.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Botulinumtoxin ( BTX ) is a neurotoxin produced from Clostridium botulinum under anaerobic conditions and is responsible for botulism , a notifiable , bacterial form of food poisoning . The first case of botulism is believed to have occurred in 1735. An epidemic in Southern Germany in 1793 claimed the death of over the half of those patients who had become ill through eating uncooked blood sausages . The term \" pharmakon \" is Greek and implicates that a drug originates from poison ( potion , remedy ) . Theophrastus Bombast von Hohenheim known as Paracelsus ( 1493/94-1541 ) first described this duality with his dictum \" alle ding sind gift und nichts on gift ; alein die dosis macht das ein ding kein gift ist \" ( only the dose makes a remedy poisonous ) . In Baden-Wuerttemberg in 1817 , the poet and physician Dr. Justinus Christian Kerner described the symptoms of botulism , so that at this time botulism was also called Kerner disease . Until the turn of the century the reason for poisoning was not known . Van Ermengem succeeded in isolat-ing the anaerobic bacterium causing botulism , but the specific mechanism of BTX was only established after the second World War . In the late seventies the ophthalmologist Dr. Alan Scott used BTX the first time in the treatment of strabismus . The drug was then used in the treatment of several muscle spasticities such as , for example , torticollis or hemifacial spasm . Only recently BTX has been successfully used for focal hyperhidrosis . We review the history of botulinum toxin from its discovery in the nineteenth century and the research into its effect in the middle of the 20th century up to its clinical use at the present time ."
],
"offsets": [
[
0,
1695
]
]
}
] |
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DerHautarzt.00510746.eng.abstr
|
DerHautarzt.00510746.eng.abstr
|
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[] |
[] |
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DerHautarzt.00510753.eng.abstr
|
DerHautarzt.00510753.eng.abstr
|
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DerHautarzt.00510759.eng.abstr
|
DerHautarzt.00510759.eng.abstr
|
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[] |
[] |
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"id": "DerHautarzt.00510759.eng.abstr-s2-r12-t6.1-t4.1",
"type": "issue_in",
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"arg2_id": "DerHautarzt.00510759.eng.abstr-s2-t4",
"normalized": []
},
{
"id": "DerHautarzt.00510759.eng.abstr-s2-r13-t3.1-t4.1",
"type": "issue_in",
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"arg2_id": "DerHautarzt.00510759.eng.abstr-s2-t4",
"normalized": []
},
{
"id": "DerHautarzt.00510759.eng.abstr-s2-r14-t1.1-t6.1",
"type": "treats",
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"arg2_id": "DerHautarzt.00510759.eng.abstr-s2-t6",
"normalized": []
},
{
"id": "DerHautarzt.00510759.eng.abstr-s2-r15-t5.2-t1.1",
"type": "uses",
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"arg2_id": "DerHautarzt.00510759.eng.abstr-s4-t1",
"normalized": []
},
{
"id": "DerHautarzt.00510759.eng.abstr-s2-r16-t1.1-t3.1",
"type": "treats",
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"arg2_id": "DerHautarzt.00510759.eng.abstr-s4-t3",
"normalized": []
},
{
"id": "DerHautarzt.00510759.eng.abstr-s2-r17-t6.1-t5.2",
"type": "associated_with",
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"arg2_id": "DerHautarzt.00510759.eng.abstr-s2-t5",
"normalized": []
},
{
"id": "DerHautarzt.00510759.eng.abstr-s2-r18-t5.2-t6.1",
"type": "associated_with",
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"arg2_id": "DerHautarzt.00510759.eng.abstr-s2-t6",
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},
{
"id": "DerHautarzt.00510759.eng.abstr-s2-r19-t3.1-t6.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.00510759.eng.abstr-s4-t3",
"arg2_id": "DerHautarzt.00510759.eng.abstr-s2-t6",
"normalized": []
},
{
"id": "DerHautarzt.00510759.eng.abstr-s4-r1-t2.1-t1.1",
"type": "interacts_with",
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"arg2_id": "DerHautarzt.00510759.eng.abstr-s4-t1",
"normalized": []
}
] |
DerHautarzt.00510763.eng.abstr
|
DerHautarzt.00510763.eng.abstr
|
[
{
"id": "DerHautarzt.00510763.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The \" biker's nodule \" is a rarely appearing perineal nodular induration of the cyclist . Repeated microtrauma to the subcutaneous fatty tissue or collageneous tissue , caused by pressure or vibration which the bicycle's saddle exerts on the perineal region , leads to collagenous degeneration , myxoid alteration and pseudocyst formation . Because of the painful subcutaneous nodules the patient is often forced to reduce or even give up his training . Therapy of the \" biker's nodule \" consists in avoiding the pathogenetic factors , i.e. giving up training for a temporary period of time and reducing pressure on the perineal region . Intralesional injection of either hyaluronidase or corticosteroids may also be helpful ."
],
"offsets": [
[
0,
726
]
]
}
] |
[
{
"id": "DerHautarzt.00510763.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"tissue"
],
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[
137,
143
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0040300"
}
]
},
{
"id": "DerHautarzt.00510763.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"tissue"
],
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[
160,
166
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0040300"
}
]
},
{
"id": "DerHautarzt.00510763.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"pressure"
],
"offsets": [
[
179,
187
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0033095"
}
]
},
{
"id": "DerHautarzt.00510763.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"vibration"
],
"offsets": [
[
191,
200
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0459800"
}
]
},
{
"id": "DerHautarzt.00510763.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"bicycle's"
],
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[
211,
220
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0605770"
}
]
},
{
"id": "DerHautarzt.00510763.eng.abstr-s2-t6",
"type": "umlsterm",
"text": [
"fatty tissue"
],
"offsets": [
[
131,
143
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0001527"
}
]
},
{
"id": "DerHautarzt.00510763.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"patient"
],
"offsets": [
[
389,
396
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.00510763.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"training"
],
"offsets": [
[
443,
451
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0040607"
},
{
"db_name": "UMLS",
"db_id": "C0220931"
}
]
},
{
"id": "DerHautarzt.00510763.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"Therapy"
],
"offsets": [
[
454,
461
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0087111"
},
{
"db_name": "UMLS",
"db_id": "C0039798"
}
]
},
{
"id": "DerHautarzt.00510763.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"training"
],
"offsets": [
[
551,
559
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0040607"
},
{
"db_name": "UMLS",
"db_id": "C0220931"
}
]
},
{
"id": "DerHautarzt.00510763.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"period"
],
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[
576,
582
]
],
"normalized": [
{
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"db_id": "C0025344"
}
]
},
{
"id": "DerHautarzt.00510763.eng.abstr-s4-t4",
"type": "umlsterm",
"text": [
"time"
],
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[
586,
590
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0040223"
}
]
},
{
"id": "DerHautarzt.00510763.eng.abstr-s4-t5",
"type": "umlsterm",
"text": [
"pressure"
],
"offsets": [
[
604,
612
]
],
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}
]
},
{
"id": "DerHautarzt.00510763.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"injection"
],
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[
652,
661
]
],
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{
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"db_id": "C0021485"
}
]
},
{
"id": "DerHautarzt.00510763.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"hyaluronidase"
],
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[
672,
685
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0020197"
}
]
},
{
"id": "DerHautarzt.00510763.eng.abstr-s5-t3",
"type": "umlsterm",
"text": [
"corticosteroids"
],
"offsets": [
[
689,
704
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0001617"
}
]
},
{
"id": "DerHautarzt.00510763.eng.abstr-s5-t4",
"type": "umlsterm",
"text": [
"Intralesional injection"
],
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[
638,
661
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0021490"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.00510763.eng.abstr-s2-r1-t5.1-t4.1",
"type": "affects",
"arg1_id": "DerHautarzt.00510763.eng.abstr-s4-t5",
"arg2_id": "DerHautarzt.00510763.eng.abstr-s5-t4",
"normalized": []
},
{
"id": "DerHautarzt.00510763.eng.abstr-s2-r2-t1.1-t5.1",
"type": "produces",
"arg1_id": "DerHautarzt.00510763.eng.abstr-s5-t1",
"arg2_id": "DerHautarzt.00510763.eng.abstr-s4-t5",
"normalized": []
},
{
"id": "DerHautarzt.00510763.eng.abstr-s2-r3-t2.1-t5.1",
"type": "produces",
"arg1_id": "DerHautarzt.00510763.eng.abstr-s5-t2",
"arg2_id": "DerHautarzt.00510763.eng.abstr-s4-t5",
"normalized": []
},
{
"id": "DerHautarzt.00510763.eng.abstr-s3-r1-t1.1-t2.2",
"type": "performs",
"arg1_id": "DerHautarzt.00510763.eng.abstr-s5-t1",
"arg2_id": "DerHautarzt.00510763.eng.abstr-s4-t2",
"normalized": []
},
{
"id": "DerHautarzt.00510763.eng.abstr-s3-r2-t1.1-t2.1",
"type": "performs",
"arg1_id": "DerHautarzt.00510763.eng.abstr-s5-t1",
"arg2_id": "DerHautarzt.00510763.eng.abstr-s5-t2",
"normalized": []
},
{
"id": "DerHautarzt.00510763.eng.abstr-s3-r3-t2.1-t1.1",
"type": "affects",
"arg1_id": "DerHautarzt.00510763.eng.abstr-s5-t2",
"arg2_id": "DerHautarzt.00510763.eng.abstr-s5-t1",
"normalized": []
},
{
"id": "DerHautarzt.00510763.eng.abstr-s4-r1-t5.1-t1.1",
"type": "conceptual_part_of",
"arg1_id": "DerHautarzt.00510763.eng.abstr-s4-t5",
"arg2_id": "DerHautarzt.00510763.eng.abstr-s5-t1",
"normalized": []
},
{
"id": "DerHautarzt.00510763.eng.abstr-s4-r2-t5.1-t2.1",
"type": "conceptual_part_of",
"arg1_id": "DerHautarzt.00510763.eng.abstr-s4-t5",
"arg2_id": "DerHautarzt.00510763.eng.abstr-s5-t2",
"normalized": []
},
{
"id": "DerHautarzt.00510763.eng.abstr-s4-r3-t4.1-t1.1",
"type": "conceptual_part_of",
"arg1_id": "DerHautarzt.00510763.eng.abstr-s5-t4",
"arg2_id": "DerHautarzt.00510763.eng.abstr-s5-t1",
"normalized": []
},
{
"id": "DerHautarzt.00510763.eng.abstr-s4-r4-t1.1-t4.1",
"type": "conceptual_part_of",
"arg1_id": "DerHautarzt.00510763.eng.abstr-s5-t1",
"arg2_id": "DerHautarzt.00510763.eng.abstr-s5-t4",
"normalized": []
},
{
"id": "DerHautarzt.00510763.eng.abstr-s4-r5-t5.1-t1.1",
"type": "measurement_of",
"arg1_id": "DerHautarzt.00510763.eng.abstr-s4-t5",
"arg2_id": "DerHautarzt.00510763.eng.abstr-s5-t1",
"normalized": []
},
{
"id": "DerHautarzt.00510763.eng.abstr-s5-r1-t4.1-t1.1",
"type": "isa",
"arg1_id": "DerHautarzt.00510763.eng.abstr-s5-t4",
"arg2_id": "DerHautarzt.00510763.eng.abstr-s5-t1",
"normalized": []
},
{
"id": "DerHautarzt.00510763.eng.abstr-s5-r2-t2.1-t3.1",
"type": "interacts_with",
"arg1_id": "DerHautarzt.00510763.eng.abstr-s5-t2",
"arg2_id": "DerHautarzt.00510763.eng.abstr-s5-t3",
"normalized": []
},
{
"id": "DerHautarzt.00510763.eng.abstr-s5-r3-t3.1-t2.1",
"type": "interacts_with",
"arg1_id": "DerHautarzt.00510763.eng.abstr-s5-t3",
"arg2_id": "DerHautarzt.00510763.eng.abstr-s5-t2",
"normalized": []
},
{
"id": "DerHautarzt.00510763.eng.abstr-s5-r4-t4.1-t2.1",
"type": "uses",
"arg1_id": "DerHautarzt.00510763.eng.abstr-s5-t4",
"arg2_id": "DerHautarzt.00510763.eng.abstr-s5-t2",
"normalized": []
}
] |
DerHautarzt.00510766.eng.abstr
|
DerHautarzt.00510766.eng.abstr
|
[
{
"id": "DerHautarzt.00510766.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Verrucous carcinomas represent rare , highly differentiated variants of squamous cell carcinoma . They preferentially develop on the oropharyngeal mucosa ( Ackerman tumor ) , the urogenital mucosa ( Buschke-Loewenstein tumors ) , and the soles of the feet ( epitheliomata cuniculata ) . Various synonyma have been coined for these tumors . We report the uncommon occurrence of a large verrucous carcinoma on apparently uninvolved chest skin of a 79-year old patient . The tumor was excised radically . Complete extirpation was confirmed histologically and there was no sign of recurrence during a 3 month observation period . The clinical appearance , histomorphological features , epidemiological aspects , differential diagnosis , therapy , and nomenclature of verrucous carcinomas are discussed ."
],
"offsets": [
[
0,
799
]
]
}
] |
[
{
"id": "DerHautarzt.00510766.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"carcinomas"
],
"offsets": [
[
10,
20
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0007097"
}
]
},
{
"id": "DerHautarzt.00510766.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"cell"
],
"offsets": [
[
81,
85
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0007634"
}
]
},
{
"id": "DerHautarzt.00510766.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"carcinoma"
],
"offsets": [
[
86,
95
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0007097"
}
]
},
{
"id": "DerHautarzt.00510766.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"Verrucous carcinomas"
],
"offsets": [
[
0,
20
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0206706"
}
]
},
{
"id": "DerHautarzt.00510766.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"squamous cell carcinoma"
],
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[
72,
95
]
],
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{
"db_name": "UMLS",
"db_id": "C0007137"
}
]
},
{
"id": "DerHautarzt.00510766.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"mucosa"
],
"offsets": [
[
147,
153
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0026724"
}
]
},
{
"id": "DerHautarzt.00510766.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"tumor"
],
"offsets": [
[
165,
170
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027651"
}
]
},
{
"id": "DerHautarzt.00510766.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"mucosa"
],
"offsets": [
[
190,
196
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0026724"
}
]
},
{
"id": "DerHautarzt.00510766.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"tumors"
],
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[
219,
225
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027651"
}
]
},
{
"id": "DerHautarzt.00510766.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"soles"
],
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[
238,
243
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0037613"
}
]
},
{
"id": "DerHautarzt.00510766.eng.abstr-s2-t6",
"type": "umlsterm",
"text": [
"feet"
],
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[
251,
255
]
],
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{
"db_name": "UMLS",
"db_id": "C0016504"
}
]
},
{
"id": "DerHautarzt.00510766.eng.abstr-s2-t7",
"type": "umlsterm",
"text": [
"epitheliomata"
],
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[
258,
271
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0007097"
}
]
},
{
"id": "DerHautarzt.00510766.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"tumors"
],
"offsets": [
[
331,
337
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027651"
}
]
},
{
"id": "DerHautarzt.00510766.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"occurrence"
],
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[
363,
373
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0243132"
}
]
},
{
"id": "DerHautarzt.00510766.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"carcinoma"
],
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[
395,
404
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0007097"
}
]
},
{
"id": "DerHautarzt.00510766.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"chest"
],
"offsets": [
[
430,
435
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0039992"
}
]
},
{
"id": "DerHautarzt.00510766.eng.abstr-s4-t4",
"type": "umlsterm",
"text": [
"skin"
],
"offsets": [
[
436,
440
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.00510766.eng.abstr-s4-t5",
"type": "umlsterm",
"text": [
"old"
],
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[
454,
457
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0331059"
}
]
},
{
"id": "DerHautarzt.00510766.eng.abstr-s4-t6",
"type": "umlsterm",
"text": [
"patient"
],
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[
458,
465
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.00510766.eng.abstr-s4-t7",
"type": "umlsterm",
"text": [
"verrucous carcinoma"
],
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[
385,
404
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0206706"
}
]
},
{
"id": "DerHautarzt.00510766.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"tumor"
],
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[
472,
477
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027651"
}
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DerHautarzt.00510770.eng.abstr
|
DerHautarzt.00510770.eng.abstr
|
[
{
"id": "DerHautarzt.00510770.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 64-year-old woman presented with extensive erythematous papulosquamous lesions along the lines of Blaschko on the right half of the trunk and the right leg . The clinical and histological features led to the diagnosis of lichen striatus , a dermatosis which usually appears during childhood . Treatment with acitretin led to marked improvement . Lichen striatus and its differential diagnoses - particulary \" blaschkitis of adulthood \" as first described in 1990 - are discussed ."
],
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}
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[] |
[] |
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DerHautarzt.00510774.eng.abstr
|
DerHautarzt.00510774.eng.abstr
|
[
{
"id": "DerHautarzt.00510774.eng.abstr-passage-0",
"type": "abstract",
"text": [
"E. Grosshans and L. Marot first described blaschkitis in 1990 as a linear inflammatory dermatitis following lines of Blaschko in an adult patient . We report another case which occurred in a 38-year-old woman who developed an extensive , linear , erythematosquamous dermatitis involving the face , all limbs and the trunk . The patient's serum tested positive for antinuclear antibodies at a dilution of 1:640 . The lesions regressed spontaneously within 4 weeks . Blaschkitis is a distinct entity which corresponds neither to a known inflammatory dermatitis in the lines of Blaschko nor to an hamartoma nor to an X-linked disease . Cutaneous antigenic mosaicism , the expression of which might be induced by a viral infection , could trigger this localized inflammatory T-cell response . This hypothesis relates blaschkitis to other cutaneous autoimmune diseases , as does the presence of antinuclear antibodies . We therefore suggest renaming this type of inflammatory dermatitis Grosshans-Marot disease in honour to the dermatologists who first described the entity ."
],
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[] |
[] |
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DerHautarzt.00510809.eng.abstr
|
DerHautarzt.00510809.eng.abstr
|
[
{
"id": "DerHautarzt.00510809.eng.abstr-passage-0",
"type": "abstract",
"text": [
"During the last few years the fast development of different laser and laser-like systems for photoepilation and their one-sided representation in media has led to confusion among pysicians and patients . The object of this review is to give a structured report of different pulsed laser and laser-like systems ( Epilight , Photoderm , long-pulsed ruby- , alexandrite- and diodelaser ) that are available in Germany , including their side effects and complications . The current status of scientific investigation in this field is discussed ."
],
"offsets": [
[
0,
541
]
]
}
] |
[
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"id": "DerHautarzt.00510809.eng.abstr-s1-t3",
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"laser"
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{
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"id": "DerHautarzt.00510809.eng.abstr-s2-t4",
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},
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},
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"id": "DerHautarzt.00510809.eng.abstr-s2-t6",
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"id": "DerHautarzt.00510809.eng.abstr-s2-t7",
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},
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"id": "DerHautarzt.00510809.eng.abstr-s2-t8",
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},
{
"id": "DerHautarzt.00510809.eng.abstr-s2-t9",
"type": "umlsterm",
"text": [
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],
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}
] |
[] |
[] |
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DerHautarzt.00510826.eng.abstr
|
DerHautarzt.00510826.eng.abstr
|
[
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0,
240
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[] |
[] |
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DerHautarzt.00510833.eng.abstr
|
DerHautarzt.00510833.eng.abstr
|
[
{
"id": "DerHautarzt.00510833.eng.abstr-passage-0",
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}
] |
[] |
[] |
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"id": "DerHautarzt.00510833.eng.abstr-s3-r4-t2.1-t1.1",
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DerHautarzt.00510838.eng.abstr
|
DerHautarzt.00510838.eng.abstr
|
[
{
"id": "DerHautarzt.00510838.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Background and Objective . Penicillin allergy is a common clinical problem . The distinction between penicillin and para-infectious exanthems is difficult . We investigated the reliability of the history , as well as the sensitivity and specificity of skin tests and specific IgE levels ."
],
"offsets": [
[
0,
288
]
]
}
] |
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{
"id": "DerHautarzt.00510838.eng.abstr-s1-t1",
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15,
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}
]
},
{
"id": "DerHautarzt.00510838.eng.abstr-s2-t1",
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"Penicillin"
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27,
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}
]
},
{
"id": "DerHautarzt.00510838.eng.abstr-s2-t2",
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"allergy"
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38,
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]
},
{
"id": "DerHautarzt.00510838.eng.abstr-s3-t1",
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"penicillin"
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101,
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]
],
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}
]
},
{
"id": "DerHautarzt.00510838.eng.abstr-s3-t2",
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"text": [
"para-infectious"
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116,
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"db_id": "C0030563"
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]
},
{
"id": "DerHautarzt.00510838.eng.abstr-s3-t3",
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"text": [
"exanthems"
],
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132,
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]
],
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"db_id": "C0015230"
}
]
},
{
"id": "DerHautarzt.00510838.eng.abstr-s4-t1",
"type": "umlsterm",
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"history"
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]
},
{
"id": "DerHautarzt.00510838.eng.abstr-s4-t2",
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221,
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},
{
"id": "DerHautarzt.00510838.eng.abstr-s4-t3",
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"specificity"
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237,
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"db_id": "C0037791"
}
]
},
{
"id": "DerHautarzt.00510838.eng.abstr-s4-t4",
"type": "umlsterm",
"text": [
"skin"
],
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[
252,
256
]
],
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"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.00510838.eng.abstr-s4-t5",
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{
"id": "DerHautarzt.00510838.eng.abstr-s4-t6",
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276,
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},
{
"id": "DerHautarzt.00510838.eng.abstr-s4-t7",
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252,
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]
},
{
"id": "DerHautarzt.00510838.eng.abstr-s4-t8",
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221,
248
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],
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{
"db_name": "UMLS",
"db_id": "C0036668"
}
]
}
] |
[] |
[] |
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},
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},
{
"id": "DerHautarzt.00510838.eng.abstr-s3-r10-t1.2-t3.1",
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},
{
"id": "DerHautarzt.00510838.eng.abstr-s4-r1-t1.2-t7.1",
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},
{
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{
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},
{
"id": "DerHautarzt.00510838.eng.abstr-s4-r11-t7.1-t1.1",
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},
{
"id": "DerHautarzt.00510838.eng.abstr-s4-r12-t7.1-t2.1",
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"arg2_id": "DerHautarzt.00510838.eng.abstr-s4-t2",
"normalized": []
}
] |
DerHautarzt.00510846.eng.abstr
|
DerHautarzt.00510846.eng.abstr
|
[
{
"id": "DerHautarzt.00510846.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Leg ulcers may be caused by many different diseases . Most frequently , they are due to vasculopathies , to a lesser extent to metabolic , neuropathic or hematologic diseases . Neoplasms , connective tissue diseases , infections , trauma , and panniculitis should also be included in the differential diagnosis . A 38-year-old Caucasian female patient with hereditary prolidase deficiency developed progressive and very painful leg ulcers . The ulcers first appeared in childhood and did not respond to various treatments . Additional features of prolidase deficiency included mental retardation , short stature , extensive dental caries , and multiple malar teleangiectases . Hereditary prolidase deficiency is a very rare autosomal recessive disease . It is caused by heterogeneous mutations of the prolidase gene and affects many aspects of protein metabolism . Ion exchange chromatography and high voltage electrophoresis of urine can prove the suspected diagnosis . So far , there is no efficient therapy for hereditary prolidase deficiency . All reported treatment attempts have ended in failure ."
],
"offsets": [
[
0,
1103
]
]
}
] |
[
{
"id": "DerHautarzt.00510846.eng.abstr-s1-t1",
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"text": [
"Leg"
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3
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},
{
"id": "DerHautarzt.00510846.eng.abstr-s1-t2",
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"text": [
"ulcers"
],
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4,
10
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{
"id": "DerHautarzt.00510846.eng.abstr-s1-t3",
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{
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{
"id": "DerHautarzt.00510846.eng.abstr-s2-t2",
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{
"id": "DerHautarzt.00510846.eng.abstr-s3-t1",
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{
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"infections"
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"db_id": "C0021311"
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"db_id": "C0021501"
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}
]
},
{
"id": "DerHautarzt.00510846.eng.abstr-s3-t6",
"type": "umlsterm",
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],
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"id": "DerHautarzt.00510846.eng.abstr-s3-t7",
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"diagnosis"
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},
{
"id": "DerHautarzt.00510846.eng.abstr-s3-t8",
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"db_id": "C0009780"
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{
"id": "DerHautarzt.00510846.eng.abstr-s3-t9",
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{
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{
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DerHautarzt.00510852.eng.abstr
|
DerHautarzt.00510852.eng.abstr
|
[
{
"id": "DerHautarzt.00510852.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In patients with painful , possibly hemorrhagic vesicles or black crusts , especially on hands/fingers or face/neck with typical history ( contact to cows or feral/cats ) the possibility of a cowpox/catpox infection has to be considered . The clinical diagnosis can be confirmed with the electron microscopy ; cytoplasmic inclusions may be detected histologically . Further useful diagnostic tools are the identification of the cowpox/catpox virus by PCR or in cell culture as well as serological tests to detect virus specific antibodies . We report the development of typical skin lesions of a cowpox/catpox infection in two female patients who had contact with cows or cats . Recent diagnostic and therapeutic approaches are also discussed ."
],
"offsets": [
[
0,
744
]
]
}
] |
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3,
11
]
],
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}
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},
{
"id": "DerHautarzt.00510852.eng.abstr-s1-t2",
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"text": [
"black"
],
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[
60,
65
]
],
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}
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],
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]
],
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]
},
{
"id": "DerHautarzt.00510852.eng.abstr-s1-t4",
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"cows"
],
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]
],
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],
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[
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215
]
],
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},
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"id": "DerHautarzt.00510852.eng.abstr-s2-t1",
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],
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]
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{
"id": "DerHautarzt.00510852.eng.abstr-s2-t2",
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DerHautarzt.00510857.eng.abstr
|
DerHautarzt.00510857.eng.abstr
|
[
{
"id": "DerHautarzt.00510857.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 76-year-old woman presented with a venous leg ulcer 7. Incidentally hemorrhagic macules on hands and fingers and dystrophy of toe and fingernails were noticed . Except for submammary erythema , no further dermatologic signs were shown . Histology of palmar lesions fit with a hemorrhagic lesion of dyskeratosis follicularis in acral skin . During following months actinic induced reddish-brown hyperkeratotic papules appeared on the forehead and in seborrheic and intertriginous areas of the trunk . Papules were most prominent during summer and almost completely resolved in winter . The hemorrhagic variant of dyskeratosis follicularis represents a rare clinical variant which has to be separated from other purpuric macules on acral sites ."
],
"offsets": [
[
0,
745
]
]
}
] |
[
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],
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{
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}
] |
[] |
[] |
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"id": "DerHautarzt.00510857.eng.abstr-s1-r15-t1.1-t7.1",
"type": "associated_with",
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"arg2_id": "DerHautarzt.00510857.eng.abstr-s1-t7",
"normalized": []
},
{
"id": "DerHautarzt.00510857.eng.abstr-s1-r16-t6.1-t3.1",
"type": "location_of",
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},
{
"id": "DerHautarzt.00510857.eng.abstr-s1-r17-t3.1-t7.1",
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},
{
"id": "DerHautarzt.00510857.eng.abstr-s1-r18-t5.1-t7.1",
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},
{
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},
{
"id": "DerHautarzt.00510857.eng.abstr-s1-r20-t2.1-t3.1",
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},
{
"id": "DerHautarzt.00510857.eng.abstr-s1-r21-t4.1-t5.1",
"type": "adjacent_to",
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"arg2_id": "DerHautarzt.00510857.eng.abstr-s1-t5",
"normalized": []
},
{
"id": "DerHautarzt.00510857.eng.abstr-s1-r22-t1.1-t3.1",
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"arg2_id": "DerHautarzt.00510857.eng.abstr-s3-t3",
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},
{
"id": "DerHautarzt.00510857.eng.abstr-s1-r23-t6.1-t7.1",
"type": "location_of",
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"arg2_id": "DerHautarzt.00510857.eng.abstr-s1-t7",
"normalized": []
},
{
"id": "DerHautarzt.00510857.eng.abstr-s1-r24-t7.1-t3.1",
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"arg2_id": "DerHautarzt.00510857.eng.abstr-s3-t3",
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},
{
"id": "DerHautarzt.00510857.eng.abstr-s2-r1-t2.1-t1.1",
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},
{
"id": "DerHautarzt.00510857.eng.abstr-s2-r2-t1.1-t2.1",
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},
{
"id": "DerHautarzt.00510857.eng.abstr-s3-r1-t3.1-t1.1",
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},
{
"id": "DerHautarzt.00510857.eng.abstr-s3-r2-t3.1-t1.2",
"type": "isa",
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"arg2_id": "DerHautarzt.00510857.eng.abstr-s3-t1",
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},
{
"id": "DerHautarzt.00510857.eng.abstr-s3-r3-t1.2-t3.1",
"type": "evaluation_of",
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"arg2_id": "DerHautarzt.00510857.eng.abstr-s3-t3",
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},
{
"id": "DerHautarzt.00510857.eng.abstr-s3-r4-t1.2-t1.1",
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"arg1_id": "DerHautarzt.00510857.eng.abstr-s3-t1",
"arg2_id": "DerHautarzt.00510857.eng.abstr-s4-t1",
"normalized": []
}
] |
DerHautarzt.00510862.eng.abstr
|
DerHautarzt.00510862.eng.abstr
|
[
{
"id": "DerHautarzt.00510862.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Neurofibromatosis is a neuroectodermal systemic disease . A rare variant of this condition is bilateral segmental neurofibromatosis . A 29-year-old man presented with bilateral papillomatous plaques in the lumbar dermatomes . Clinically , the lesions were very similar to an epidermal nevus but histologic examination revealed superficial neurofibromas . Family history , ophthalmologic and neurologic investigations were unremarkable . The unusual morphologic presentation of bilateral segmental neurofibromas in this case points to the wide clinical spectrum of the disease and the significance of histologic examination in systematic nevoid lesions ."
],
"offsets": [
[
0,
653
]
]
}
] |
[
{
"id": "DerHautarzt.00510862.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"Neurofibromatosis"
],
"offsets": [
[
0,
17
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0162678"
}
]
},
{
"id": "DerHautarzt.00510862.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"Neurofibromatosis"
],
"offsets": [
[
0,
17
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0016048"
}
]
},
{
"id": "DerHautarzt.00510862.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"disease"
],
"offsets": [
[
48,
55
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0012634"
}
]
},
{
"id": "DerHautarzt.00510862.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"Neurofibromatosis is"
],
"offsets": [
[
0,
20
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027831"
}
]
},
{
"id": "DerHautarzt.00510862.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"neurofibromatosis"
],
"offsets": [
[
114,
131
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0162678"
}
]
},
{
"id": "DerHautarzt.00510862.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"man"
],
"offsets": [
[
148,
151
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0025266"
},
{
"db_name": "UMLS",
"db_id": "C0024554"
}
]
},
{
"id": "DerHautarzt.00510862.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"plaques"
],
"offsets": [
[
191,
198
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011389"
},
{
"db_name": "UMLS",
"db_id": "C0333463"
}
]
},
{
"id": "DerHautarzt.00510862.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"nevus"
],
"offsets": [
[
285,
290
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027960"
}
]
},
{
"id": "DerHautarzt.00510862.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"histologic"
],
"offsets": [
[
295,
305
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0205462"
}
]
},
{
"id": "DerHautarzt.00510862.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"neurofibromas"
],
"offsets": [
[
339,
352
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027830"
}
]
},
{
"id": "DerHautarzt.00510862.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"Family"
],
"offsets": [
[
355,
361
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0015576"
}
]
},
{
"id": "DerHautarzt.00510862.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"history"
],
"offsets": [
[
362,
369
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0019664"
},
{
"db_name": "UMLS",
"db_id": "C0019665"
}
]
},
{
"id": "DerHautarzt.00510862.eng.abstr-s6-t1",
"type": "umlsterm",
"text": [
"neurofibromas"
],
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497,
510
]
],
"normalized": [
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"db_id": "C0027830"
}
]
},
{
"id": "DerHautarzt.00510862.eng.abstr-s6-t2",
"type": "umlsterm",
"text": [
"disease"
],
"offsets": [
[
568,
575
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0012634"
}
]
},
{
"id": "DerHautarzt.00510862.eng.abstr-s6-t3",
"type": "umlsterm",
"text": [
"histologic"
],
"offsets": [
[
600,
610
]
],
"normalized": [
{
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"db_id": "C0205462"
}
]
},
{
"id": "DerHautarzt.00510862.eng.abstr-s6-t4",
"type": "umlsterm",
"text": [
"systematic"
],
"offsets": [
[
626,
636
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0220922"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.00510862.eng.abstr-s1-r1-t2.1-t4.1",
"type": "degree_of",
"arg1_id": "DerHautarzt.00510862.eng.abstr-s6-t2",
"arg2_id": "DerHautarzt.00510862.eng.abstr-s6-t4",
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},
{
"id": "DerHautarzt.00510862.eng.abstr-s1-r2-t2.1-t1.1",
"type": "degree_of",
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"arg2_id": "DerHautarzt.00510862.eng.abstr-s6-t1",
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},
{
"id": "DerHautarzt.00510862.eng.abstr-s3-r1-t2.2-t1.2",
"type": "associated_with",
"arg1_id": "DerHautarzt.00510862.eng.abstr-s5-t2",
"arg2_id": "DerHautarzt.00510862.eng.abstr-s3-t1",
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},
{
"id": "DerHautarzt.00510862.eng.abstr-s3-r2-t2.2-t1.2",
"type": "result_of",
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"arg2_id": "DerHautarzt.00510862.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "DerHautarzt.00510862.eng.abstr-s3-r3-t1.2-t2.2",
"type": "associated_with",
"arg1_id": "DerHautarzt.00510862.eng.abstr-s3-t1",
"arg2_id": "DerHautarzt.00510862.eng.abstr-s5-t2",
"normalized": []
},
{
"id": "DerHautarzt.00510862.eng.abstr-s3-r4-t1.2-t2.2",
"type": "result_of",
"arg1_id": "DerHautarzt.00510862.eng.abstr-s3-t1",
"arg2_id": "DerHautarzt.00510862.eng.abstr-s5-t2",
"normalized": []
},
{
"id": "DerHautarzt.00510862.eng.abstr-s3-r5-t2.2-t1.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.00510862.eng.abstr-s5-t2",
"arg2_id": "DerHautarzt.00510862.eng.abstr-s6-t1",
"normalized": []
},
{
"id": "DerHautarzt.00510862.eng.abstr-s3-r6-t1.2-t1.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.00510862.eng.abstr-s3-t1",
"arg2_id": "DerHautarzt.00510862.eng.abstr-s6-t1",
"normalized": []
},
{
"id": "DerHautarzt.00510862.eng.abstr-s3-r7-t1.1-t2.2",
"type": "associated_with",
"arg1_id": "DerHautarzt.00510862.eng.abstr-s6-t1",
"arg2_id": "DerHautarzt.00510862.eng.abstr-s5-t2",
"normalized": []
},
{
"id": "DerHautarzt.00510862.eng.abstr-s3-r8-t1.1-t1.2",
"type": "associated_with",
"arg1_id": "DerHautarzt.00510862.eng.abstr-s6-t1",
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"normalized": []
},
{
"id": "DerHautarzt.00510862.eng.abstr-s5-r1-t1.1-t2.2",
"type": "uses",
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"arg2_id": "DerHautarzt.00510862.eng.abstr-s5-t2",
"normalized": []
},
{
"id": "DerHautarzt.00510862.eng.abstr-s5-r2-t1.1-t2.1",
"type": "issue_in",
"arg1_id": "DerHautarzt.00510862.eng.abstr-s6-t1",
"arg2_id": "DerHautarzt.00510862.eng.abstr-s6-t2",
"normalized": []
},
{
"id": "DerHautarzt.00510862.eng.abstr-s5-r3-t2.2-t2.1",
"type": "issue_in",
"arg1_id": "DerHautarzt.00510862.eng.abstr-s5-t2",
"arg2_id": "DerHautarzt.00510862.eng.abstr-s6-t2",
"normalized": []
},
{
"id": "DerHautarzt.00510862.eng.abstr-s6-r1-t2.1-t1.1",
"type": "degree_of",
"arg1_id": "DerHautarzt.00510862.eng.abstr-s6-t2",
"arg2_id": "DerHautarzt.00510862.eng.abstr-s6-t1",
"normalized": []
},
{
"id": "DerHautarzt.00510862.eng.abstr-s6-r2-t1.1-t2.1",
"type": "degree_of",
"arg1_id": "DerHautarzt.00510862.eng.abstr-s6-t1",
"arg2_id": "DerHautarzt.00510862.eng.abstr-s6-t2",
"normalized": []
}
] |
DerHautarzt.00510865.eng.abstr
|
DerHautarzt.00510865.eng.abstr
|
[
{
"id": "DerHautarzt.00510865.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Cystic tumors of the neck are usually cysts , inflamatory masses , lymph nodes , benign and malignant tumors or metastases . Malformations are less common . Ectopic salivary tissue is a rather rare but clinically important malformation . Accessory and aberrant tissue can be identified histologically . There may be an association with lymphatic tissue . Possible complications include inflammation as well as the development of benign and in rare cases malignant salivary gland tumors . We report on two patients who underwent surgical treatment under the tentative diagnosis of epidermal cysts which histologically turned out to be ectopic parotid tissue ."
],
"offsets": [
[
0,
658
]
]
}
] |
[
{
"id": "DerHautarzt.00510865.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"tumors"
],
"offsets": [
[
7,
13
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027651"
}
]
},
{
"id": "DerHautarzt.00510865.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"neck"
],
"offsets": [
[
21,
25
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027530"
}
]
},
{
"id": "DerHautarzt.00510865.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"cysts"
],
"offsets": [
[
38,
43
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0010709"
}
]
},
{
"id": "DerHautarzt.00510865.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"lymph"
],
"offsets": [
[
67,
72
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0024202"
}
]
},
{
"id": "DerHautarzt.00510865.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"malignant"
],
"offsets": [
[
92,
101
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0006826"
}
]
},
{
"id": "DerHautarzt.00510865.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"tumors"
],
"offsets": [
[
102,
108
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027651"
}
]
},
{
"id": "DerHautarzt.00510865.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"metastases"
],
"offsets": [
[
112,
122
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027627"
}
]
},
{
"id": "DerHautarzt.00510865.eng.abstr-s1-t8",
"type": "umlsterm",
"text": [
"lymph nodes"
],
"offsets": [
[
67,
78
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0024204"
}
]
},
{
"id": "DerHautarzt.00510865.eng.abstr-s1-t9",
"type": "umlsterm",
"text": [
"malignant tumors"
],
"offsets": [
[
92,
108
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0006826"
}
]
},
{
"id": "DerHautarzt.00510865.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"Malformations"
],
"offsets": [
[
125,
138
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0000768"
},
{
"db_name": "UMLS",
"db_id": "C0243070"
}
]
},
{
"id": "DerHautarzt.00510865.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"Ectopic"
],
"offsets": [
[
157,
164
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0015374"
}
]
},
{
"id": "DerHautarzt.00510865.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"tissue"
],
"offsets": [
[
174,
180
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0040300"
}
]
},
{
"id": "DerHautarzt.00510865.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"malformation"
],
"offsets": [
[
223,
235
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0000768"
},
{
"db_name": "UMLS",
"db_id": "C0243070"
}
]
},
{
"id": "DerHautarzt.00510865.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"tissue"
],
"offsets": [
[
261,
267
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0040300"
}
]
},
{
"id": "DerHautarzt.00510865.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"aberrant tissue"
],
"offsets": [
[
252,
267
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0008519"
}
]
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DerHautarzt.40450004.eng.abstr
|
DerHautarzt.40450004.eng.abstr
|
[
{
"id": "DerHautarzt.40450004.eng.abstr-passage-0",
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"text": [
"Abstract . In Western Germany there are at least 2000 self-help groups concerned with dermatological conditions . Besides therapeutic functions , self-help groups deal with prophylaxis and public relations . Interaction between self-help groups and doctors is biased by expectations of support on the self-help groups ' side and fears and prejudices on the doctors ' side . Thus , for the benefit of their own patients doctors should be well informed about self-help groups working in their region , as the quality of help received from these groups varies widely . In this paper we have listed superregional contact addresses of self-help groups ."
],
"offsets": [
[
0,
648
]
]
}
] |
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DerHautarzt.40450008.eng.abstr
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DerHautarzt.40450008.eng.abstr
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DerHautarzt.40450012.eng.abstr
|
DerHautarzt.40450012.eng.abstr
|
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"Abstract . Of a total of 131 patients suffering from chronic urticaria , 15 were cautiously reexposed to ASA after an initial provocative exposure during an urticaria test programme 2 - 11 years before . Only 1 of these patients , who had undergone the initial provocative test 7 years earlier , reacted at the same intensity ; 1 other patient reacted with much less intense symptoms 4 years after the original test . Among 3 other patients , who merely reacted to ASA intake with urticarial eruptions and did not suffer from chronic urticaria , only 1 presented 4 years after the initial exposure with oedema of the skin and itching . The tolerance threshold was markedly higher . These results suggest that the sensitivity to intolerance-inducing agents is reduced relatively quickly and may subside completely in most cases ."
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DerHautarzt.40450015.eng.abstr
|
DerHautarzt.40450015.eng.abstr
|
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"Abstract . Comparison by skin epiluminescent microscopy of 60 malignant melanomas and 130 junctional and compound naevocellular naevi revealed statistically significant differences for 12 characteristics . The following microscopical in vivo signs that can be defined by histopathological examination were found only in malignant or premalignant melanocytic lesions : digitated radial streaming , greyish-blue reticular patterns , opaque gypseous alabaster lacunas , brown/black dots on a blue/greyish background , pseudopodia at the periphery and blue-in-pink areas . Nevertheless , specific epiluminescent phenomena of histopathologically defined malignant melanomas are still unknown . Therefore , diagnostic evaluation of malignancy is based mainly on microscopic assessment of combined details of morphology and colour of melanocytic tumours ."
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"normalized": []
},
{
"id": "DerHautarzt.40450015.eng.abstr-s5-r16-t1.1-t3.1",
"type": "associated_with",
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"arg2_id": "DerHautarzt.40450015.eng.abstr-s5-t3",
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},
{
"id": "DerHautarzt.40450015.eng.abstr-s5-r17-t3.1-t5.1",
"type": "result_of",
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},
{
"id": "DerHautarzt.40450015.eng.abstr-s5-r18-t1.1-t2.1",
"type": "associated_with",
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"arg2_id": "DerHautarzt.40450015.eng.abstr-s5-t2",
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},
{
"id": "DerHautarzt.40450015.eng.abstr-s5-r19-t2.1-t5.1",
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"arg2_id": "DerHautarzt.40450015.eng.abstr-s5-t5",
"normalized": []
}
] |
DerHautarzt.40450020.eng.abstr
|
DerHautarzt.40450020.eng.abstr
|
[
{
"id": "DerHautarzt.40450020.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . Seminal plasma transferrin concentrations were measured in semen samples from 424 men attending a fertility unit . There was a clear positive correlation between seminal plasma transferrin concentration and sperm density : transferrin concentrations decrease with decreasing sperm density and are lowest in patients with azoospermia and those who have undergone vasectomy . The differences between the various groups in sperm density are highly significant , but individual data counts also vary widely . Furthermore , it was demonstrated that in polyzoospermia the seminal plasma transferrin concentration is increased , suggesting primary tubular hyperactivity . No correlations with other seminal parameters or hormonal values were found . Seminal plasma transferrin concentrations in normozoospermia and in varicocele testis or in cases with increased numbers of immature germ cells in the ejaculate were not significantly different . This may be interpreted as indicative of intact secretory activity of Sertoli cells in both varicocele and increased desquamation of immature germ cells . The absence of correlation with any of several important spermatological parameters and our inability to differentiate between azoospermia caused by obstruction and by tubular impairment indicate that seminal plasma transferrin is not a useful marker for Sertoli cell function or for seminiferous tubular dysfunction ."
],
"offsets": [
[
0,
1423
]
]
}
] |
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"Abstract"
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},
{
"id": "DerHautarzt.40450020.eng.abstr-s2-t1",
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"plasma"
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19,
25
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],
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"db_name": "UMLS",
"db_id": "C0032105"
}
]
},
{
"id": "DerHautarzt.40450020.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"transferrin"
],
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[
26,
37
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],
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{
"db_name": "UMLS",
"db_id": "C0040679"
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},
{
"id": "DerHautarzt.40450020.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"concentrations"
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[
38,
52
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{
"db_name": "UMLS",
"db_id": "C0086045"
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]
},
{
"id": "DerHautarzt.40450020.eng.abstr-s2-t4",
"type": "umlsterm",
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"semen"
],
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[
70,
75
]
],
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{
"db_name": "UMLS",
"db_id": "C0036614"
}
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},
{
"id": "DerHautarzt.40450020.eng.abstr-s2-t5",
"type": "umlsterm",
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"men"
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[
93,
96
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"db_name": "UMLS",
"db_id": "C0024554"
}
]
},
{
"id": "DerHautarzt.40450020.eng.abstr-s2-t6",
"type": "umlsterm",
"text": [
"fertility"
],
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[
109,
118
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],
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{
"db_name": "UMLS",
"db_id": "C0015895"
}
]
},
{
"id": "DerHautarzt.40450020.eng.abstr-s2-t7",
"type": "umlsterm",
"text": [
"Seminal plasma"
],
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[
11,
25
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],
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"db_name": "UMLS",
"db_id": "C0242499"
}
]
},
{
"id": "DerHautarzt.40450020.eng.abstr-s3-t1",
"type": "umlsterm",
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"plasma"
],
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[
181,
187
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],
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{
"db_name": "UMLS",
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}
]
},
{
"id": "DerHautarzt.40450020.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"transferrin"
],
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188,
199
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},
{
"id": "DerHautarzt.40450020.eng.abstr-s3-t3",
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"concentration"
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200,
213
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"db_name": "UMLS",
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}
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},
{
"id": "DerHautarzt.40450020.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"sperm"
],
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218,
223
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{
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}
]
},
{
"id": "DerHautarzt.40450020.eng.abstr-s3-t5",
"type": "umlsterm",
"text": [
"transferrin"
],
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234,
245
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],
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},
{
"id": "DerHautarzt.40450020.eng.abstr-s3-t6",
"type": "umlsterm",
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"concentrations"
],
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246,
260
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]
},
{
"id": "DerHautarzt.40450020.eng.abstr-s3-t7",
"type": "umlsterm",
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"sperm"
],
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286,
291
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},
{
"id": "DerHautarzt.40450020.eng.abstr-s3-t8",
"type": "umlsterm",
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"patients"
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318,
326
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},
{
"id": "DerHautarzt.40450020.eng.abstr-s3-t9",
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"azoospermia"
],
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[
332,
343
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],
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]
},
{
"id": "DerHautarzt.40450020.eng.abstr-s3-t10",
"type": "umlsterm",
"text": [
"vasectomy"
],
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[
373,
382
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],
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"db_id": "C0042387"
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]
},
{
"id": "DerHautarzt.40450020.eng.abstr-s3-t11",
"type": "umlsterm",
"text": [
"seminal plasma"
],
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[
173,
187
]
],
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"db_name": "UMLS",
"db_id": "C0242499"
}
]
},
{
"id": "DerHautarzt.40450020.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"sperm"
],
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[
431,
436
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],
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"db_name": "UMLS",
"db_id": "C0037868"
}
]
},
{
"id": "DerHautarzt.40450020.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"plasma"
],
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585,
591
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"db_name": "UMLS",
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}
]
},
{
"id": "DerHautarzt.40450020.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"transferrin"
],
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[
592,
603
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],
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"db_name": "UMLS",
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]
},
{
"id": "DerHautarzt.40450020.eng.abstr-s5-t3",
"type": "umlsterm",
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"concentration"
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604,
617
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},
{
"id": "DerHautarzt.40450020.eng.abstr-s5-t4",
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"hyperactivity"
],
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660,
673
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"id": "DerHautarzt.40450020.eng.abstr-s5-t5",
"type": "umlsterm",
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577,
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{
"id": "DerHautarzt.40450020.eng.abstr-s7-t1",
"type": "umlsterm",
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},
{
"id": "DerHautarzt.40450020.eng.abstr-s7-t2",
"type": "umlsterm",
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"transferrin"
],
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769,
780
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},
{
"id": "DerHautarzt.40450020.eng.abstr-s7-t3",
"type": "umlsterm",
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795
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},
{
"id": "DerHautarzt.40450020.eng.abstr-s7-t4",
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"varicocele"
],
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822,
832
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},
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"id": "DerHautarzt.40450020.eng.abstr-s7-t5",
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"testis"
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833,
839
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"db_id": "C0021358"
}
]
},
{
"id": "DerHautarzt.40450020.eng.abstr-s7-t6",
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"cells"
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892,
897
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},
{
"id": "DerHautarzt.40450020.eng.abstr-s7-t7",
"type": "umlsterm",
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"Seminal plasma"
],
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754,
768
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},
{
"id": "DerHautarzt.40450020.eng.abstr-s7-t8",
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"germ cells"
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887,
897
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{
"id": "DerHautarzt.40450020.eng.abstr-s8-t1",
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},
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"id": "DerHautarzt.40450020.eng.abstr-s8-t2",
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1042,
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"id": "DerHautarzt.40450020.eng.abstr-s8-t3",
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{
"id": "DerHautarzt.40450020.eng.abstr-s8-t4",
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},
{
"id": "DerHautarzt.40450020.eng.abstr-s9-t1",
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},
{
"id": "DerHautarzt.40450020.eng.abstr-s9-t2",
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},
{
"id": "DerHautarzt.40450020.eng.abstr-s9-t3",
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1332
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1381
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},
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"id": "DerHautarzt.40450020.eng.abstr-s9-t8",
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"dysfunction"
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1421
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},
{
"id": "DerHautarzt.40450020.eng.abstr-s9-t9",
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"seminal plasma"
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1306,
1320
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},
{
"id": "DerHautarzt.40450020.eng.abstr-s9-t10",
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1360,
1372
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},
{
"id": "DerHautarzt.40450020.eng.abstr-s9-t11",
"type": "umlsterm",
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"cell function"
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1368,
1381
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],
"normalized": [
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"db_id": "C0007613"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.40450020.eng.abstr-s2-r1-t3.1-t7.1",
"type": "produces",
"arg1_id": "DerHautarzt.40450020.eng.abstr-s9-t3",
"arg2_id": "DerHautarzt.40450020.eng.abstr-s9-t7",
"normalized": []
},
{
"id": "DerHautarzt.40450020.eng.abstr-s2-r2-t3.1-t2.1",
"type": "consists_of",
"arg1_id": "DerHautarzt.40450020.eng.abstr-s9-t3",
"arg2_id": "DerHautarzt.40450020.eng.abstr-s9-t2",
"normalized": []
},
{
"id": "DerHautarzt.40450020.eng.abstr-s2-r3-t5.2-t3.1",
"type": "measurement_of",
"arg1_id": "DerHautarzt.40450020.eng.abstr-s7-t5",
"arg2_id": "DerHautarzt.40450020.eng.abstr-s9-t3",
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},
{
"id": "DerHautarzt.40450020.eng.abstr-s2-r4-t1.1-t2.1",
"type": "consists_of",
"arg1_id": "DerHautarzt.40450020.eng.abstr-s9-t1",
"arg2_id": "DerHautarzt.40450020.eng.abstr-s9-t2",
"normalized": []
},
{
"id": "DerHautarzt.40450020.eng.abstr-s2-r5-t3.1-t1.1",
"type": "produces",
"arg1_id": "DerHautarzt.40450020.eng.abstr-s9-t3",
"arg2_id": "DerHautarzt.40450020.eng.abstr-s9-t1",
"normalized": []
},
{
"id": "DerHautarzt.40450020.eng.abstr-s2-r6-t2.1-t3.1",
"type": "affects",
"arg1_id": "DerHautarzt.40450020.eng.abstr-s9-t2",
"arg2_id": "DerHautarzt.40450020.eng.abstr-s9-t3",
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},
{
"id": "DerHautarzt.40450020.eng.abstr-s2-r7-t3.1-t2.1",
"type": "produces",
"arg1_id": "DerHautarzt.40450020.eng.abstr-s9-t3",
"arg2_id": "DerHautarzt.40450020.eng.abstr-s9-t2",
"normalized": []
},
{
"id": "DerHautarzt.40450020.eng.abstr-s2-r8-t3.1-t5.2",
"type": "affects",
"arg1_id": "DerHautarzt.40450020.eng.abstr-s9-t3",
"arg2_id": "DerHautarzt.40450020.eng.abstr-s7-t5",
"normalized": []
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DerHautarzt.40450025.eng.abstr
|
DerHautarzt.40450025.eng.abstr
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"Abstract . Subungual keratoacanthomas ( SKA ) differ in clinical presentation , biological behaviour and the therapy needed from keratoacanthomas in other localizations . Against the backdrop of two personal observations and a review of the literature , the authors describe clinical and histological features and also the differential diagnosis and therapy and this rare benign neoplasm . Patients present with a rapidly growing , painful subungual mass , which causes destruction of the underlying bone and usually does not regress spontaneously . Histological differentiation from squamous cell carcinoma is essential as the prognosis and treatment are different . SKA is treated by local excision and curettage . Erosions of the underlying distal phalanx usually heal spontaneously . However , persistent recurrences after subtotal excision often necessitate amputation of the distal phalanx ."
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] |
DerHautarzt.40450029.eng.abstr
|
DerHautarzt.40450029.eng.abstr
|
[
{
"id": "DerHautarzt.40450029.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . We report a 34-year-old homosexual man who developed a maculopapular , non-itchy exanthema mainly on the trunk in addition to fever up to 39.8 °C, general malaise , arthralgias , generalized enlargement of the lymph nodes , watery diarrhoea and weight loss . The patient was in an acute phase of the HIV infection according to standards of WHO and CDC ( i.e. acute infection with duration from 3 days to 3 weeks with occasional mononucleosis-like symptoms and positive antibody tests ) . We documented the seroconversion from HIV-negativity to HIV-positivity 15 days after the onset of the acute illness , concomitant with the resolution of the clinical symptoms . Haematological changes were monitored during the conversion . The infection with HIV-1 was shown by the reduction of T4 helper cells ( 262/µl) and the inversion of the CD4:CD8 ratio ( 0.5 during seroconversion ) . The patient also developed generalized candidiasis owing to the acute immunodeficiency ."
],
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[
0,
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]
]
}
] |
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"id": "DerHautarzt.40450029.eng.abstr-s2-t3",
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"id": "DerHautarzt.40450029.eng.abstr-s2-t8",
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"id": "DerHautarzt.40450029.eng.abstr-s2-t9",
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"id": "DerHautarzt.40450029.eng.abstr-s2-t11",
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"id": "DerHautarzt.40450029.eng.abstr-s2-t12",
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] |
[] |
[] |
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{
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{
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DerHautarzt.40450034.eng.abstr
|
DerHautarzt.40450034.eng.abstr
|
[
{
"id": "DerHautarzt.40450034.eng.abstr-passage-0",
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"text": [
"Abstract . Targetoid haemosiderotic haemangioma ( THH ) can be differentiated from other angiomatous lesions by the characteristic findings on clinical and histological examination . Clinically the solitary lesions is suggestive of a melanocytic or angiomatous origin , surrounded by a haemorrhagic halo in the acute phase . Histological findings vary depending on the duration of the alteration . The pattern has a superficial and a deep dermal component . In the papillary body lesional capillaries are lined by prominent endothelial cells . The surrounding tissue is oedematous and contains masses of erythrocytes or haemosiderin and a lymphocytic infiltrate . Vessels in the deeper dermis have a lymphatic appearance and surround adnexal structures . Further possible similarities with Kaposi sarcoma are dissecting vascular lumina between collagen bundles and spindle cell areas . However , has no atypical cells , eosinophilic globules or apoptotic endothelial cells . Immunohistochemical investigations , which have now revealed BMA 120 for the first time in THH as well as factor VIII-R antigen and Ulex europaeus I lectin , have not so far made any substantial contribution to the differential diagnosis and histogenesis of THH , because markers distinguishing lymphatic from vascular endothelia are still lacking ."
],
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}
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] |
[] |
[] |
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DerHautarzt.40450038.eng.abstr
|
DerHautarzt.40450038.eng.abstr
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"text": [
"Abstract . Lupus panniculitis is a rare variant of cutaneous lupus erythematosus . Two typical cases demonstrate the association of lupus panniculitis with signs of discoid lupus erythematosus and systemic lupus erythematosus . Clinically it is characterised by subcutaneous nodules or plaques , which may ulcerate leaving depressed atrophic scars . Histologically the lesions show lobular panniculitis . A positive immunofluorescent band test with deposition of IgG , IgM and C3 at the dermal-epidermal junction and blood vessel walls helps to confirm the diagnosis . The knowledge of the clinical features and histopathology of the disease is important because lupus panniculitis may precede systemic lupus erythematosus by some years ."
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[] |
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DerHautarzt.40450065.eng.abstr
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"Abstract . On the basis of an extensive literature search ( DIMDI , MEDLINE - status at June 1992 ) , the causes of contact urticaria so far known are displayed in tables . The contact urticariogens can be divided into ( 1 ) chemically defined substances and ( 2 ) chemically undefined biological materials . The causes most frequently encountered in 16 professions are given . Numerous agents are known for medical professions ( physicians , nurses , dentists and dental technicians , veterinary surgeons ) . Today , the most frequent single cause of contact urticaria is probably the presence of latex proteins in rubber ( gloves , condoms , tubes , balloons , etc. ) . When testing is performed a stepwise approach is recommended for safety reasons ( rub test , prick test , scratch chamber test ) . For some contact urticariogens a commercial radioallergosorbent test ( RAST ) is available . In the cases reported in the literature it is not always possible to decide definitely whether the pathogenetic mechanism was immunologic ( IgE mediated ) or non-immunologic ( toxic or pseudoallergic ) . When there is a high degree of sensitization ( e.g. to latex ) professional activities must be severely restricted , or even completely discontinued in rare cases ."
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DerHautarzt.40450074.eng.abstr
|
DerHautarzt.40450074.eng.abstr
|
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"Abstract . Since systemic treatment of neuropathic plantar ulcers in diabetics ( DNPU ) has so far been rather ineffective , recent reports of successful management of DNPU by short-term retrograde transvenous leg perfusions ( RVP ) by South American angiologists encouraged us to apply this treatment method in diabetics suffering from chronic DNPU . Hence , in a prospective comparative clinical trial started in 1989 we have treated 45 male diabetics suffering from DNPU with the same daily doses of netilmycin , administered either in systemic venous infusions ( SVI : n=21, three times/day ) or in RVP ( n=24, once/day ) . After 10 consecutive days of treatment , ulcers had closed in 8 of the 24 patients treated with RVP , as against 3 of the 21 treated with SVI . Diminution of the ulcer area by > 30% including full debridement was achieved in 10/24 of the RVP cases ( SVI : 4/21 ) . During 6 months of follow-up , amputation of toes or forefoot was necessary in only 1 patient in the RVP group , but in 4 in the SVI group . Partial restitution of osteolytic damage was observed in some cases after RVP . Our results show that regional netilmycin therapy given by the RVP procedure is clearly superior to equal netilmycin doses administered by SVI for the treatment of DNPU . RVP can be recommended in DNPU , particularly when the ulcers are complicated by infections ."
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DerHautarzt.40450080.eng.abstr
|
DerHautarzt.40450080.eng.abstr
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"text": [
"Abstract . A 20-year-old female patient with the typical signs of Wissler's subsepsis allergica ( Wissler-Fanconi syndrome ) is described . This rare disease is characterized by four typical symptoms : polymorphous exanthemas , recurrent high fever , leucocytosis and arthralgia . In the early stages it is difficult to differentiate from septicaemia . This syndrome has sometimes been considered equivalent to or an initial stage of Still's disease ( juvenile rheumatoid arthritis ) progressing to degenerative arthritis in many patients , whereas other authors have classified it as a separate entity with good prognosis . The present case demonstrates that Wissler's subsepsis allergica should be considered whenever transient polymorphous exanthema is accompanied by high recurrent fever , leucocytosis and arthralgia ."
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[] |
[] |
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DerHautarzt.40450084.eng.abstr
|
DerHautarzt.40450084.eng.abstr
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[
{
"id": "DerHautarzt.40450084.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . Suramin has long been used in the treatment of onchocerciasis and trypanosomiasis . Recent investigations showed an antiproliferative effect of suramin on prostate carcinoma cell lines . Ongoing clinical trials have confirmed the effect of suramin on metastasizing prostate carcinoma . Five patients with metastatic prostate carcinoma resistant to classic hormonal therapy were treated with high-dose suramin . Four of the five developed a papulovesicular or maculopapular rash within 2 - 4 weeks of starting therapy . The rashes disappeared after discontinuation of suramin within 10 days . In tumour therapy , high dosages of suramin are used to achieve a serum level of 200 - 300 µg/ml. Therefore , a toxic reaction to suramin is suspected as the explanation for the skin rashes ."
],
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] |
[] |
[] |
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] |
DerHautarzt.40450088.eng.abstr
|
DerHautarzt.40450088.eng.abstr
|
[
{
"id": "DerHautarzt.40450088.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . Pachydermodactyly is an acquired , asymptomatic swelling of the lateral sides of the fingers and is seen mainly in young men . The formal pathogenesis is a benign fibromatosis . The causal pathogenesis was until now unclear , although we believe , that exogenic factors are the main reason . Consequently pachydermodactyly has to be considered as a result of compulsion neurosis ."
],
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0,
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}
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[] |
[] |
[
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{
"id": "DerHautarzt.40450088.eng.abstr-s5-r2-t1.1-t2.1",
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DerHautarzt.40450091.eng.abstr
|
DerHautarzt.40450091.eng.abstr
|
[
{
"id": "DerHautarzt.40450091.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . Multicentric reticulohistiocytosis ( MRH ) is a rare disorder of skin and joints , and its aetiology is unknown . We describe a male patient who had first developed osteoblastic lesions of the skeleton in 1976 at the age of 59 years . Three years later , he presented with multiple papular and nodular skin lesions , predominantly on the limbs and upper trunk , and 4 years later he developed painful arthropathy . In 1988 skin examination showed multiple brownish-red papulo-nodules , some of which , at mechanically stressed areas , were ulcerated . The patient complained of pronounced arthrotic disorders with reduced joint mobility . Examination of biopsy specimens from active skin lesions demonstrated extensive numbers of macrophages with partial confluence to giant cells with typical ground-glass cytoplasm . Electron microscopy revealed phagocytosis of collagen-like structures . Examination of bone marrow biopsy specimens revealed diffuse infiltration by histiocytic cells . The diganosis made was therefore MRH . The patient was treated for several years with different therapeutic regimens , including azathioprin , dapsone , prednisolon , chlorambucil and cyclophosphamide , and complete remission of skin lesions and of bone marrow infiltration was observed . However , a myelodysplastic syndrome with refractory anaemia and ring sideroblasts developed , which is generally understood to be a preleukaemic condition . Myelodysplastic syndromes commonly develop between 3 and 10 years after the start of a therapy with antineoplastic agents ."
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"id": "DerHautarzt.40450091.eng.abstr-s3-t3",
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"type": "umlsterm",
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DerHautarzt.40450097.eng.abstr
|
DerHautarzt.40450097.eng.abstr
|
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{
"id": "DerHautarzt.40450097.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . The case of a 63-year-old woman suffering from generalized bullous pemphigoid with localized pemphigoid mimicking dyshidrosiform dermatitis is presented . Dyshidrosiform pemphigoid is an unusual variant of localized pemphigoid ; clinically it mimics dyshidrosiform dermatitis , for example ."
],
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"id": "DerHautarzt.40450097.eng.abstr-s3-t3",
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] |
[] |
[] |
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DerHautarzt.40450100.eng.abstr
|
DerHautarzt.40450100.eng.abstr
|
[
{
"id": "DerHautarzt.40450100.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . We present the case of an infant with Waterhouse-Friderichsen syndrome , in whom keloids developed at the sites of intracutanous bleeding within 6 months after the illness ."
],
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0,
184
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"id": "DerHautarzt.40450100.eng.abstr-s2-t1",
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DerHautarzt.40450108.eng.abstr
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DerHautarzt.40450108.eng.abstr
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[] |
[] |
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DerHautarzt.40450133.eng.abstr
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DerHautarzt.40450133.eng.abstr
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"id": "DerHautarzt.40450133.eng.abstr-passage-0",
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"Abstract . Dermatosurgery has been gaining in importance in recent years . In departments of dermatology German-speaking countries the total number of operations increased by 58% from 1984 to 1991. The increase in the number of operations of moderate and extreme severity was especially marked . Out-patient dermatosurgery was also performed mainly by dermatologists as opposed to other specialties . From 1988 to 1992 dermatologists in private practice recorded an increase of 40.6% in the number of operative procedures they performed . The importance of dermatosurgery in hospital and private practice can be expected to continue increasing in the future ; dermatologists must therefore prepare themselves for the present and future challenges inherent in surgery of the skin ."
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DerHautarzt.40450140.eng.abstr
|
DerHautarzt.40450140.eng.abstr
|
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"Abstract . Balneo-phototherapy , in which salt baths are followed by UV-B irradiation , has proved successful in the treatment of psoriasis . Because of practical problems , the major one of which is the large turnover of bath solution volumes , balneotherapy has so far been limited to specialized treatment centres . With the aid of a polyethylene foil the volume of bathing solutions needed can be reduced to a total of 4 l per bath . Balneotherapy using small bath solution volumes for total body treatment can now be applied as an outpatient regimen for salt bath and bath-PUVA therapy . The methods for establishing balneotherapy with restricted water volumes and the advantages of bath-PUVA over conventional oral psoralen therapy are described ."
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[] |
[] |
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DerHautarzt.40450145.eng.abstr
|
DerHautarzt.40450145.eng.abstr
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"Abstract . Late recurrence of malignant melanoma , defined as the occurrence of metastases after a disease-free interval of 10 or more years , is a rare but well-known clinical phenomenon . We report on three female patients who developed in transit metastases 26 , 15 and 10 years after excision of the primary tumour . All three patients are disease-free 8 and 9 years after resection of the metastases . Reports in the literature also indicate a favourable prognosis for patients with local recurrence or in transit or regional lymph node metastases . The prognosis for patients with late distant metastases , however , is generally poor . For the first group , an early therapeutic intervention is indicated . This and the occurrence of second and multiple primary melanomas make lifelong aftercare desirable . On the other hand , long-term aftercare of the constantly increasing number of melanoma patients will soon exceed the capacity of existing facilities . A high-risk group for late recurrence that would profit by long-term aftercare cannot be defined at the moment ."
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[] |
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DerHautarzt.40450149.eng.abstr
|
DerHautarzt.40450149.eng.abstr
|
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"id": "DerHautarzt.40450149.eng.abstr-passage-0",
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"text": [
"Abstract . Our report describes a 46-year-old woman with self-inflicted oedema of the left leg and the left arm . She induced leg oedema by an elastic bandage tourniquet and arm oedema by holding her arm dependent and immobile . A preexisting disorder of the affected leg ( postthrombotic syndrome ) and of the affected arm ( hypoesthesia subsequent to surgical injury of the plexus brachialis ) delayed the diagnostic proceedings . Our case report shows that : - Confirmed presence of organic disease does not exclude limb oedema of self-inflicted origin . - Oedema resulting from a tourniquet and \" hysterical oedema \" can be developed by one and the same patient . - Effective care of such patients is only possible if dermatologist and psychiatrist work together all the time ( liaison psychiatry ) ."
],
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]
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DerHautarzt.40450154.eng.abstr
|
DerHautarzt.40450154.eng.abstr
|
[
{
"id": "DerHautarzt.40450154.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . In several cases of lupus erythematosus ( SLE , SCLE , DLE ) , the Koebner phenomenon could be seen in the apparently normal skin of patients following traumas , scratching effects , operation scars , contact dermatitis , pressure from sock tops , application of liquid nitrogen , exposure to strong sun light , etc. The interval between exposure to such provocation factors and appearance of the isomorphic reactions varied from case to case . In SLE patients receiving systemic treatment with glucocorticosteroids , the Koebner phenomenon could not be found , while it was detected in patients with generalized DLE who had never received any systemic glucocorticoid hormones . It was not seen in patients with localized DLE . There was no direct relationship between the appearance of humoral autoantibodies and onset of the Koebner phenomenon . With regard to the histopathogenesis of the Koebner phenomenon , it is thought that disturbances of the local cellular repair processes and of the cytokine network , with expression of adhesion molecules , might be involved . The Koebner phenomenon may be a valuable model for the investigation of lupus erythematosus ."
],
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]
]
}
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}
] |
DerHautarzt.40450161.eng.abstr
|
DerHautarzt.40450161.eng.abstr
|
[
{
"id": "DerHautarzt.40450161.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . Biopsy specimens of involved and uninvolved skin were studied in four patients suffering from generalized lichen planus ( LP ) before and after successful oral PUVA treatment with murine monoclonal antibodies against several cellular adhesion molecules . In contrast to untreated LP lesions , in biopsies obtained after PUVA therapy from healed involved skin we found markedly diminished to completely absent expression of CD54(ICAM-1), HLA-DR , CD11a/18(LFA-1) and CD49f(VLA-6) on keratinocytes and an effective loss of CD49a(VLA-1)-, CD49c(VLA-3)-, CD49d(VLA-4)-, CD49f(VLA-6)-, CD3- and CD8-positive infiltrating cells . Our data demonstrate the influence of PUVA on cell-cell and cell-matrix adhesion in patients with LP ."
],
"offsets": [
[
0,
737
]
]
}
] |
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{
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"Biopsy"
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},
{
"id": "DerHautarzt.40450161.eng.abstr-s2-t2",
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"skin"
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55,
59
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"patients"
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"lichen"
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"db_id": "C0023657"
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"id": "DerHautarzt.40450161.eng.abstr-s2-t5",
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"planus"
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124,
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{
"id": "DerHautarzt.40450161.eng.abstr-s2-t7",
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"murine"
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"id": "DerHautarzt.40450161.eng.abstr-s2-t8",
"type": "umlsterm",
"text": [
"antibodies"
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209,
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{
"id": "DerHautarzt.40450161.eng.abstr-s2-t9",
"type": "umlsterm",
"text": [
"adhesion"
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245,
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},
{
"id": "DerHautarzt.40450161.eng.abstr-s2-t10",
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"text": [
"lichen planus"
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"db_id": "C0023646"
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"id": "DerHautarzt.40450161.eng.abstr-s2-t11",
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"monoclonal antibodies"
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{
"id": "DerHautarzt.40450161.eng.abstr-s2-t12",
"type": "umlsterm",
"text": [
"cellular adhesion"
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236,
253
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"db_id": "C0007577"
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},
{
"id": "DerHautarzt.40450161.eng.abstr-s2-t13",
"type": "umlsterm",
"text": [
"adhesion molecules"
],
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[
245,
263
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],
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"id": "DerHautarzt.40450161.eng.abstr-s3-t1",
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"contrast"
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269,
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},
{
"id": "DerHautarzt.40450161.eng.abstr-s3-t2",
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"text": [
"biopsies"
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307,
315
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"id": "DerHautarzt.40450161.eng.abstr-s3-t3",
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"id": "DerHautarzt.40450161.eng.abstr-s3-t4",
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"skin"
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365,
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{
"id": "DerHautarzt.40450161.eng.abstr-s3-t5",
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{
"id": "DerHautarzt.40450161.eng.abstr-s3-t6",
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"keratinocytes"
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493,
506
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"db_id": "C0022567"
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},
{
"id": "DerHautarzt.40450161.eng.abstr-s3-t7",
"type": "umlsterm",
"text": [
"cells"
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627,
632
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"db_id": "C0007634"
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]
},
{
"id": "DerHautarzt.40450161.eng.abstr-s3-t8",
"type": "umlsterm",
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"PUVA therapy"
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331,
343
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"id": "DerHautarzt.40450161.eng.abstr-s4-t1",
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"cell-cell"
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"id": "DerHautarzt.40450161.eng.abstr-s4-t2",
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"id": "DerHautarzt.40450161.eng.abstr-s4-t3",
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{
"id": "DerHautarzt.40450161.eng.abstr-s4-t6",
"type": "umlsterm",
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"cell-matrix adhesion"
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695,
715
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{
"db_name": "UMLS",
"db_id": "C0887869"
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]
}
] |
[] |
[] |
[
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{
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{
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DerHautarzt.40450166.eng.abstr
|
DerHautarzt.40450166.eng.abstr
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"Abstract . Epidermolysis bullosa acquisita ( EBA ) is an autoimmune subepidermal blistering disease , which can present in various clinical forms . We report on a 73-year-old male patient with the inflammatory type of EBA , which is clinically similar to bullous pemphigoid . Histological examination revealed subepidermal blister formation , and direct immunofluorescence of perilesional skin revealed a linear deposition of IgG and C3 at the basement membrane . Indirect immunofluorescence with 0.9% NaCl-separated human skin as substrate showed the presence of circulating antibodies binding to the base of the artificial blister at a titre of 1:320 . Indirect immunoelectronmicroscopy revealed immune deposits localized in the area of the sublamina densa . Immunoblotting of dermal extracts disclosed binding of serum antibodies to a 290-kDa protein . Systemic therapy with diaminodiphenyl sulphone , initially in combination with corticosteroids , resulted in complete healing of the skin lesions . With reference to this case report , we discuss the clinical pictures possible in EBA , the differential diagnosis and the treatment options ."
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DerHautarzt.40450176.eng.abstr
|
DerHautarzt.40450176.eng.abstr
|
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{
"id": "DerHautarzt.40450176.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . A 54-year-old woman patient had symptoms of stomatitis and asthma following the provision of a dental prothesis in July 1991. We found a positive patch test reaction to palladium only , without any concomitant metallic contact dermatitis ; in particular there was no sensitization to nickel . This is a very rare sensitization . After replacement of the dental alloy the clinical symptoms improved ."
],
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0,
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"id": "DerHautarzt.40450176.eng.abstr-s2-t9",
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] |
[] |
[] |
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DerHautarzt.40450179.eng.abstr
|
DerHautarzt.40450179.eng.abstr
|
[
{
"id": "DerHautarzt.40450179.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . In Schoenlein-Henoch purpura , a distinctive form of leucocytoclastic vasculitis , immune complex deposits in vessel walls characteristically contain IgA . Complement activation , neutrophil chemotaxis and the subsequent destruction of vessel walls make up the pathologic substrate behind the clinical symptoms , which are characterized by palpable purpura lesions , renal and gastrointestinal symptoms and arthralgias . Viral infections , malignant neoplasms and drugs , but especially streptococcal infections , are incriminated as possible causes of the disease . A case of Schoenlein-Henoch purpura associated with chronic osteomyelitis is described . It is noteworthy insofar as there is only one similar case reported in the literature ."
],
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[
0,
754
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]
}
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"form"
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{
"id": "DerHautarzt.40450179.eng.abstr-s2-t3",
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] |
DerHautarzt.40450207.eng.abstr
|
DerHautarzt.40450207.eng.abstr
|
[
{
"id": "DerHautarzt.40450207.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . Resulting from the infectiologically established novel definition of antiseptic which contains the local application of antiseptics for prophylactical , preventive or therapeutical indication on skin , mucous membrane , wounds , in body cavities or on surgical exposed resp. opened endosomatic areas the antiseptical indications in a branch of dermatology and venereal diseases are represented . With the analysis of the actual knowledge in vitro and in vivo requirements to local antiinfectiva are defined combined with the recommendations for the clinical use . At present mainly prophylactically used agents are submitted to a benefit risk analysis with refer to the choice of agents . Thereby agents for the application on skin as well as on genitals , in mouth cavity and on wounds were taken into consideration ."
],
"offsets": [
[
0,
829
]
]
}
] |
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"id": "DerHautarzt.40450207.eng.abstr-s2-t10",
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"knowledge"
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"id": "DerHautarzt.40450207.eng.abstr-s5-t2",
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"id": "DerHautarzt.40450207.eng.abstr-s5-t3",
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] |
[] |
[] |
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] |
DerHautarzt.40450222.eng.abstr
|
DerHautarzt.40450222.eng.abstr
|
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{
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"text": [
"Abstract . In 5 years 9 patients with a total of 16 painful ear nodules ( chondrodermatitis helicis ) have been treated as follows . A small excision is carried out with local anaesthesia for histological examination . The rest of the nodule or any other nodules are carbonized by means of the argon laser , also with local anaesthesia , including the surface of the cartilage under the nodules . There have been no cases of postoperative inflammation or infection . New nodules occurring several months after treatment have been successfully treated in the same way . There have been no real recurrences . The cosmetic result is very good in all cases . The patients are free of pain immediately after the laser therapy . Laser therapy for painful nodules of the ear has good and lasting results , with a lower rate of recurrences than any other form of treatment ."
],
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[
0,
866
]
]
}
] |
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[] |
[] |
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DerHautarzt.40450225.eng.abstr
|
DerHautarzt.40450225.eng.abstr
|
[
{
"id": "DerHautarzt.40450225.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . In this pilot study 12 patients with moderate to severe atopic eczema were treated with 2 million IU interferon alpha 2a ( Roferon A ) three times weekly for 8 weeks and followed up for a further 10 weeks : 2 patients showed clear and 9 a slight to moderate reduction of their skin lesions ; 1 patient got worse . Pruritus did not decrease and even increased in a few patients , and IgE levels showed no change during and after treatment . All patients noted mild , transient , flu-like symptoms . The efficacy of interferon alpha in the present therapeutic design for the treatment of atopic eczema must thus be classified as only moderate ."
],
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[
0,
653
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]
}
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] |
[] |
[] |
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DerHautarzt.40450228.eng.abstr
|
DerHautarzt.40450228.eng.abstr
|
[
{
"id": "DerHautarzt.40450228.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . A case of eosinophilic granuloma faciale is presented in which the lesions have been successfully treated by cryotherapy , healing with slight pigmentation . Since this disease appears to be difficult to treat , a great many forms of therapy have been proposed in the literature . These will be discussed with the results presented ."
],
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[
0,
344
]
]
}
] |
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120,
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}
]
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{
"id": "DerHautarzt.40450228.eng.abstr-s2-t3",
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"pigmentation"
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154,
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{
"id": "DerHautarzt.40450228.eng.abstr-s2-t4",
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180,
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279,
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"db_id": "C0023866"
}
]
}
] |
[] |
[] |
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] |
DerHautarzt.40450231.eng.abstr
|
DerHautarzt.40450231.eng.abstr
|
[
{
"id": "DerHautarzt.40450231.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . Many different congenital and acquired skin diseases are seen along Blaschko's lines . In 1992 , Moulin et al. [ 40 ] described five patients affected with a new clinical entity characterized by acquired atrophic band-like skin lesions showing hyperpigmentation . We report on a further patient with this skin disease . Characteristic features are hyperpigmented atrophoderma arranged in a pattern following the lines of Blaschko , with no preceding inflammation and no subsequent induration or scleroderma . The lesions usually appear during childhood or adolescence , but sometimes in young adults . For this skin disease we propose the term `linear atrophoderma of Moulin ' ."
],
"offsets": [
[
0,
689
]
]
}
] |
[
{
"id": "DerHautarzt.40450231.eng.abstr-s1-t1",
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"Abstract"
],
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0,
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]
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},
{
"id": "DerHautarzt.40450231.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"congenital"
],
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26,
36
]
],
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"db_id": "C0009678"
}
]
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{
"id": "DerHautarzt.40450231.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"skin"
],
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[
50,
54
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.40450231.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"diseases"
],
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[
55,
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DerHautarzt.40450237.eng.abstr
|
DerHautarzt.40450237.eng.abstr
|
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{
"id": "DerHautarzt.40450237.eng.abstr-passage-0",
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"text": [
"Abstract . A case with various skeletal abnormalities , soft tissue masses and skin lesions diagnosed as Proteus syndrome is reported . Proteus syndrome is included in the differential diagnosis of many disorders , because of the polymorphous nature of its clinical manifestations . It is a rare disorder and leads to functional disabilities as well as cosmetic and psychological problems . Early diagnosis and careful follow-up with appropriate surgical interventions is important in preventing long-term complications ."
],
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}
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DerHautarzt.40450249.eng.abstr
|
DerHautarzt.40450249.eng.abstr
|
[
{
"id": "DerHautarzt.40450249.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . Dyskeratosis congenita ( DC ) is a very rare form of genodermatosis with variable manifestations , which mainly affects male patients . The main clinical symptoms are poikilodermia , nail dystrophy and leucoplakia ; there are many other cutaneous and systemic symptoms . To avoid complications and improve the prognosis early diagnosis and regular close surveillance of the patients are important . We report on 13-year-old monozygotic twin brothers who , in addition to the typical symptoms , had increased vulnerability of the skin , scarring of the hands and atrophy of the oral mucosa as well as splenomegaly , pancytopenia with severe aplasia of bone marrow and aseptic necrosis of the hip . The two brothers had nearly synchronous clinical manifestation and progression . This paper reviews the clinical symptoms , pathogenesis , differential diagnosis and genetic aspects of DC ."
],
"offsets": [
[
0,
897
]
]
}
] |
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"form"
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{
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"male"
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"db_id": "C0024554"
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DerHautarzt.40450285.eng.abstr
|
DerHautarzt.40450285.eng.abstr
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DerHautarzt.40450292.eng.abstr
|
DerHautarzt.40450292.eng.abstr
|
[
{
"id": "DerHautarzt.40450292.eng.abstr-passage-0",
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"text": [
"Patch testing with commercially available test kits of known allergens often leads to detection of the responsible allergen . In many cases , however , the responsible allergen cannot be found unless the patient's \" own \" products or chemicals are tested . An analysis of 2460 patch tests with patch test kits proposed by the DKG ( German Contact Allergy Group ) and a positive history of a patient's own substance showed positive results in 208 patients with 289 products . In 44% ( 129 out of 289 ) the responsible allergen could only be found by testing the patient's own substances , in 56% ( 160 out of 289 ) the same allergen as was responsible for the positive result with patients ' endogenous substances was positive in one of the commercially available test kits . The substances that tested positive were medical products/adhesives ( 45% ) , cosmetics ( 39.4% ) , rubber materials ( 4.1% ) , leather materials ( 0.7% ) and others ( 10% ) . Subsequent testing of the different components of the patients ' own substances that tested positive was carried out in 45 cases and resulted in the detection of new allergens , such as tris- ( 2-hydroxyethyl ) isocyanurate triacrylate . In 27 patients the endogenous substances had tested positive in the course of testing for occupational dermatitis , and in 10 of these positive testing of a patient's own product resulted in notification of an occupational dermatitis . These results show , that patch testing with the patient's own products is very important for the finding of the responsible or even new allergens ."
],
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}
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[] |
[] |
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DerHautarzt.40450304.eng.abstr
|
DerHautarzt.40450304.eng.abstr
|
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"In the course of the Third Frankfurt Talks , for the first time a congress in dermatology was dedicated exclusively to cell and tissue culture models . The complexity of a whole organ , in this case the skin , could be reduced to single aspects without losing the holistic context . Ways of managing this were discussed on an interdisciplinary level by dermatologists , physiologists , pharmacologists and biologists . The results are also expected to be useful to the clinician . Focus points of in vitro investigations for dermatology are wound closure models and the use of in vitro skin for transplantation in the therapy of nonhealing ulcers and vitiligo . As an alternative to animal experiments , cultures of human cells are gaining increasing influence in drug testing . The effect of glucocorticosteroids on normal skin fibroblasts , keratinocytes and permanent cell lines is discussed as an example , and in vitro models of diseases such as psoriasis are established . Additionally , basic events such as differentiation and ageing have been modelled in cell cultures of melanocytes and keratinocytes . Mechanical stress , UV radiation and nicotine are discussed as inductors ."
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] |
DerHautarzt.40450313.eng.abstr
|
DerHautarzt.40450313.eng.abstr
|
[
{
"id": "DerHautarzt.40450313.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report on three family members suffering from both autosomal dominant Hailey-Hailey disease and bipolar affective disorder . As molecular biology techniques have made the localization of genes causing simple Mendelian traits possible as a routine task , the gene for Hailey-Hailey disease will presumably be localized in the foreseeable future . The Hailey-Hailey gene and its chromosomal surrounding will then be a region of interest for linkage studies in bipolar affective disorder ."
],
"offsets": [
[
0,
489
]
]
}
] |
[
{
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"family"
],
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19,
25
]
],
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}
]
},
{
"id": "DerHautarzt.40450313.eng.abstr-s1-t2",
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"disease"
],
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94
]
],
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}
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},
{
"id": "DerHautarzt.40450313.eng.abstr-s1-t3",
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"disorder"
],
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[
117,
125
]
],
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{
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}
]
},
{
"id": "DerHautarzt.40450313.eng.abstr-s1-t4",
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"family members"
],
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[
19,
33
]
],
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{
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"db_id": "C0086282"
}
]
},
{
"id": "DerHautarzt.40450313.eng.abstr-s1-t5",
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"Hailey-Hailey disease"
],
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[
73,
94
]
],
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}
]
},
{
"id": "DerHautarzt.40450313.eng.abstr-s1-t6",
"type": "umlsterm",
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"affective disorder"
],
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[
107,
125
]
],
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{
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}
]
},
{
"id": "DerHautarzt.40450313.eng.abstr-s1-t7",
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"bipolar affective disorder"
],
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[
99,
125
]
],
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]
},
{
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141,
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]
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{
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"techniques"
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[
149,
159
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],
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{
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}
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},
{
"id": "DerHautarzt.40450313.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"genes"
],
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[
190,
195
]
],
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{
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}
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},
{
"id": "DerHautarzt.40450313.eng.abstr-s2-t4",
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"gene"
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261,
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{
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284,
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{
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},
{
"id": "DerHautarzt.40450313.eng.abstr-s2-t8",
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],
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},
{
"id": "DerHautarzt.40450313.eng.abstr-s3-t1",
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},
{
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{
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],
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},
{
"id": "DerHautarzt.40450313.eng.abstr-s3-t5",
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],
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461,
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]
],
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{
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"db_id": "C0005586"
}
]
}
] |
[] |
[] |
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DerHautarzt.40450318.eng.abstr
|
DerHautarzt.40450318.eng.abstr
|
[
{
"id": "DerHautarzt.40450318.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Adenoid cystic carcinoma of the skin is one of the rarest sweat gland tumours . We have studied two cases of adenoid cystic sweat gland carcinoma clinically , histologically and immunohistochemically . One tumour was located on the occiput of an 18-year-old male patient , while the other developed on the back of a 49-year-old woman . Histologically , both carcinomas were characterized by basaloid tumour cells showing the typical adenoid-cystic growth pattern . The cells were arranged in solid , cribriform , tubular and cystic aggregates , which were surrounded by mucoid , Alcian blue material . Immunohistochemically , the tumour cells showed coexpression of cytokeratins typical of stratified epithelia ( CK1/5/10/14) and cytokeratins of the simple epithelial type , namely CK7, CK8, CK18, and CK19. Coexpression of these cytokeratins is usually observed in normal fetal sweat glands , but not in adult sweat glands ."
],
"offsets": [
[
0,
925
]
]
}
] |
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"adenoid"
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{
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"id": "DerHautarzt.40450318.eng.abstr-s6-r54-t1.1-t9.2",
"type": "produces",
"arg1_id": "DerHautarzt.40450318.eng.abstr-s6-t1",
"arg2_id": "DerHautarzt.40450318.eng.abstr-s6-t9",
"normalized": []
},
{
"id": "DerHautarzt.40450318.eng.abstr-s6-r55-t11.1-t5.1",
"type": "produces",
"arg1_id": "DerHautarzt.40450318.eng.abstr-s6-t11",
"arg2_id": "DerHautarzt.40450318.eng.abstr-s6-t5",
"normalized": []
},
{
"id": "DerHautarzt.40450318.eng.abstr-s6-r56-t3.1-t9.2",
"type": "surrounds",
"arg1_id": "DerHautarzt.40450318.eng.abstr-s6-t3",
"arg2_id": "DerHautarzt.40450318.eng.abstr-s6-t9",
"normalized": []
}
] |
DerHautarzt.40450324.eng.abstr
|
DerHautarzt.40450324.eng.abstr
|
[
{
"id": "DerHautarzt.40450324.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Chondroid syringoma belongs to the group of so-called mixed tumors , like pleomorphic adenomas of the lacrimal and salivary glands . The histogenesis of this tumour is still disputed , in particular with respect to its stromal component . The distribution of cytokeratins ( CKs ) , CEA , EMA , vimentin , S-100 protein , desmin and actin [ -smooth muscle actin ( -SMA ) ] was investigated by immunohistological examination of paraffin sections from a chondroid syringoma of the apocrine type . The neoplastic formations have been classified into tubuloalveolar structures , solid nests/aggregations and stromal cells of varying morphology . The innermost cells of tubuloalveolar structures were characterized by marked expression of CKs ( KL1 and MNF116 ) , CEA and EMA , while in the outer ones there was moderate expression of vimentin , S-100 was expressed to a lesser extent and KL1, weakly but there was marked and consistent expression of MNF116 . Whereas the solid nests expressed vimentin , S-100 protein , MNF116 markedly and KL1 weakly , the stromal cells were consistently positive for vimentin , S-100 protein and , focally , CKs and -SMA . Anti--SMA specifically detects myoepithelial cells . In addition , the partly overlapping immunoreactivity of the intermediate filaments , membrane proteins and proteins in the different structures may indicate a common clonal origin of all neoplastic cells in chondroid syringoma ."
],
"offsets": [
[
0,
1435
]
]
}
] |
[
{
"id": "DerHautarzt.40450324.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"syringoma"
],
"offsets": [
[
10,
19
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0206673"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"tumors"
],
"offsets": [
[
60,
66
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027651"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"adenomas"
],
"offsets": [
[
86,
94
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0001430"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"Chondroid syringoma"
],
"offsets": [
[
0,
19
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0026277"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"pleomorphic adenomas"
],
"offsets": [
[
74,
94
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0026277"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"salivary glands"
],
"offsets": [
[
115,
130
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0036098"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"tumour"
],
"offsets": [
[
158,
164
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027651"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"distribution"
],
"offsets": [
[
243,
255
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0520511"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"cytokeratins"
],
"offsets": [
[
259,
271
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0010803"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"CEA"
],
"offsets": [
[
282,
285
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0007082"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"vimentin"
],
"offsets": [
[
294,
302
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0042666"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s3-t5",
"type": "umlsterm",
"text": [
"protein"
],
"offsets": [
[
311,
318
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0033684"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s3-t6",
"type": "umlsterm",
"text": [
"desmin"
],
"offsets": [
[
321,
327
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011696"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s3-t7",
"type": "umlsterm",
"text": [
"actin"
],
"offsets": [
[
332,
337
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0001271"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s3-t8",
"type": "umlsterm",
"text": [
"muscle"
],
"offsets": [
[
348,
354
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0026845"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s3-t9",
"type": "umlsterm",
"text": [
"actin"
],
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[
355,
360
]
],
"normalized": [
{
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"db_id": "C0001271"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s3-t10",
"type": "umlsterm",
"text": [
"paraffin"
],
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[
426,
434
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030415"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s3-t11",
"type": "umlsterm",
"text": [
"syringoma"
],
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[
461,
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]
],
"normalized": [
{
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"db_id": "C0206673"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s3-t12",
"type": "umlsterm",
"text": [
"S-100 protein"
],
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[
305,
318
]
],
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"db_id": "C0086946"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s3-t13",
"type": "umlsterm",
"text": [
"-smooth muscle"
],
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[
340,
354
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0026843"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s3-t14",
"type": "umlsterm",
"text": [
"chondroid syringoma"
],
"offsets": [
[
451,
470
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0026277"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"cells"
],
"offsets": [
[
611,
616
]
],
"normalized": [
{
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"db_id": "C0007634"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"morphology"
],
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[
628,
638
]
],
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{
"db_name": "UMLS",
"db_id": "C0543482"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"stromal cells"
],
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[
603,
616
]
],
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"db_id": "C0162597"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"cells"
],
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[
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]
],
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}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"CEA"
],
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[
758,
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]
],
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{
"db_name": "UMLS",
"db_id": "C0007082"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s5-t3",
"type": "umlsterm",
"text": [
"vimentin"
],
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[
829,
837
]
],
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{
"db_name": "UMLS",
"db_id": "C0042666"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s6-t1",
"type": "umlsterm",
"text": [
"vimentin"
],
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[
988,
996
]
],
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"db_name": "UMLS",
"db_id": "C0042666"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s6-t2",
"type": "umlsterm",
"text": [
"protein"
],
"offsets": [
[
1005,
1012
]
],
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{
"db_name": "UMLS",
"db_id": "C0033684"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s6-t3",
"type": "umlsterm",
"text": [
"cells"
],
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]
],
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{
"db_name": "UMLS",
"db_id": "C0007634"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s6-t4",
"type": "umlsterm",
"text": [
"vimentin"
],
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[
1097,
1105
]
],
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"db_id": "C0042666"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s6-t5",
"type": "umlsterm",
"text": [
"protein"
],
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[
1114,
1121
]
],
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"db_id": "C0033684"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s6-t6",
"type": "umlsterm",
"text": [
"S-100 protein"
],
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[
999,
1012
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0086946"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s6-t7",
"type": "umlsterm",
"text": [
"stromal cells"
],
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1052,
1065
]
],
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"db_name": "UMLS",
"db_id": "C0162597"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s6-t8",
"type": "umlsterm",
"text": [
"S-100 protein"
],
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[
1108,
1121
]
],
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"db_name": "UMLS",
"db_id": "C0086946"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s7-t1",
"type": "umlsterm",
"text": [
"cells"
],
"offsets": [
[
1198,
1203
]
],
"normalized": [
{
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"db_id": "C0007634"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s8-t1",
"type": "umlsterm",
"text": [
"membrane"
],
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[
1292,
1300
]
],
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"db_id": "C0025255"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s8-t2",
"type": "umlsterm",
"text": [
"proteins"
],
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[
1301,
1309
]
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}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s8-t3",
"type": "umlsterm",
"text": [
"proteins"
],
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[
1314,
1322
]
],
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"db_name": "UMLS",
"db_id": "C0033684"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s8-t4",
"type": "umlsterm",
"text": [
"origin"
],
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[
1380,
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]
],
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"db_id": "C0079946"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s8-t5",
"type": "umlsterm",
"text": [
"cells"
],
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1405,
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]
],
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"db_id": "C0007634"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s8-t6",
"type": "umlsterm",
"text": [
"syringoma"
],
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[
1424,
1433
]
],
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"db_name": "UMLS",
"db_id": "C0206673"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s8-t7",
"type": "umlsterm",
"text": [
"intermediate filaments"
],
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1267,
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]
],
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"db_id": "C0021770"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s8-t8",
"type": "umlsterm",
"text": [
"membrane proteins"
],
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[
1292,
1309
]
],
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{
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"db_id": "C0025252"
}
]
},
{
"id": "DerHautarzt.40450324.eng.abstr-s8-t9",
"type": "umlsterm",
"text": [
"chondroid syringoma"
],
"offsets": [
[
1414,
1433
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0026277"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.40450324.eng.abstr-s1-r1-t6.1-t4.1",
"type": "location_of",
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"arg2_id": "DerHautarzt.40450324.eng.abstr-s8-t4",
"normalized": []
},
{
"id": "DerHautarzt.40450324.eng.abstr-s1-r2-t6.1-t5.1",
"type": "location_of",
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"arg2_id": "DerHautarzt.40450324.eng.abstr-s8-t5",
"normalized": []
},
{
"id": "DerHautarzt.40450324.eng.abstr-s1-r3-t6.1-t1.1",
"type": "location_of",
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"arg2_id": "DerHautarzt.40450324.eng.abstr-s8-t1",
"normalized": []
},
{
"id": "DerHautarzt.40450324.eng.abstr-s1-r4-t6.1-t2.1",
"type": "location_of",
"arg1_id": "DerHautarzt.40450324.eng.abstr-s8-t6",
"arg2_id": "DerHautarzt.40450324.eng.abstr-s8-t2",
"normalized": []
},
{
"id": "DerHautarzt.40450324.eng.abstr-s1-r5-t6.1-t3.1",
"type": "location_of",
"arg1_id": "DerHautarzt.40450324.eng.abstr-s8-t6",
"arg2_id": "DerHautarzt.40450324.eng.abstr-s8-t3",
"normalized": []
},
{
"id": "DerHautarzt.40450324.eng.abstr-s3-r1-t1.1-t10.1",
"type": "interacts_with",
"arg1_id": "DerHautarzt.40450324.eng.abstr-s8-t1",
"arg2_id": "DerHautarzt.40450324.eng.abstr-s3-t10",
"normalized": []
},
{
"id": "DerHautarzt.40450324.eng.abstr-s3-r2-t12.1-t14.1",
"type": "location_of",
"arg1_id": "DerHautarzt.40450324.eng.abstr-s3-t12",
"arg2_id": "DerHautarzt.40450324.eng.abstr-s3-t14",
"normalized": []
},
{
"id": "DerHautarzt.40450324.eng.abstr-s3-r3-t1.1-t7.1",
"type": "interacts_with",
"arg1_id": "DerHautarzt.40450324.eng.abstr-s8-t1",
"arg2_id": "DerHautarzt.40450324.eng.abstr-s8-t7",
"normalized": []
},
{
"id": "DerHautarzt.40450324.eng.abstr-s3-r4-t14.1-t2.1",
"type": "produces",
"arg1_id": "DerHautarzt.40450324.eng.abstr-s3-t14",
"arg2_id": "DerHautarzt.40450324.eng.abstr-s8-t2",
"normalized": []
},
{
"id": "DerHautarzt.40450324.eng.abstr-s3-r5-t10.1-t1.1",
"type": "interacts_with",
"arg1_id": "DerHautarzt.40450324.eng.abstr-s3-t10",
"arg2_id": "DerHautarzt.40450324.eng.abstr-s8-t1",
"normalized": []
},
{
"id": "DerHautarzt.40450324.eng.abstr-s3-r6-t12.1-t1.1",
"type": "produces",
"arg1_id": "DerHautarzt.40450324.eng.abstr-s3-t12",
"arg2_id": "DerHautarzt.40450324.eng.abstr-s8-t1",
"normalized": []
},
{
"id": "DerHautarzt.40450324.eng.abstr-s3-r7-t14.1-t9.1",
"type": "produces",
"arg1_id": "DerHautarzt.40450324.eng.abstr-s3-t14",
"arg2_id": "DerHautarzt.40450324.eng.abstr-s8-t9",
"normalized": []
},
{
"id": "DerHautarzt.40450324.eng.abstr-s3-r8-t11.1-t4.1",
"type": "produces",
"arg1_id": "DerHautarzt.40450324.eng.abstr-s3-t11",
"arg2_id": "DerHautarzt.40450324.eng.abstr-s8-t4",
"normalized": []
},
{
"id": "DerHautarzt.40450324.eng.abstr-s3-r9-t8.1-t5.1",
"type": "produces",
"arg1_id": "DerHautarzt.40450324.eng.abstr-s8-t8",
"arg2_id": "DerHautarzt.40450324.eng.abstr-s8-t5",
"normalized": []
},
{
"id": "DerHautarzt.40450324.eng.abstr-s3-r10-t1.1-t5.1",
"type": "interacts_with",
"arg1_id": "DerHautarzt.40450324.eng.abstr-s8-t1",
"arg2_id": "DerHautarzt.40450324.eng.abstr-s8-t5",
"normalized": []
},
{
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] |
DerHautarzt.40450330.eng.abstr
|
DerHautarzt.40450330.eng.abstr
|
[
{
"id": "DerHautarzt.40450330.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report on a 31-year-old white woman , who was bitten in her right calf by a \" spitting cobra \" ( Neia nigricollis ) during a safari in Tansania . Minor initial systemic symptoms such as nausea and vomiting were followed by severe oedematous swelling of the extremity after 2 - 3 h and demarcation of a 2.75x2.75 in . area of necrotic skin . The patient returned to her home country , where 8 days after the snake-bite necrosectomy was performed . Antibiotics , antiinflammatory agents and local therapy with hydrocolloidal wound dressings were administered . With this therapy the lesion healed completely with minor scarring within 5 months . A new Salmonella strain was isolated from the ground of the ulcer ."
],
"offsets": [
[
0,
714
]
]
}
] |
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}
]
},
{
"id": "DerHautarzt.40450330.eng.abstr-s7-t1",
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"Salmonella"
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[
653,
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]
],
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}
]
},
{
"id": "DerHautarzt.40450330.eng.abstr-s7-t2",
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"strain"
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"id": "DerHautarzt.40450330.eng.abstr-s7-t3",
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"ulcer"
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]
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{
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"db_id": "C0041582"
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]
}
] |
[] |
[] |
[
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}
] |
DerHautarzt.40450339.eng.abstr
|
DerHautarzt.40450339.eng.abstr
|
[
{
"id": "DerHautarzt.40450339.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Necrobiotic xanthogranuloma is a non-X histiocytosis with unknown pathogenesis . It is associated with paraproteinaemia , and in rare cases with multiple myeloma . A decreased level of C1 inhibitor has been found in several cases without clinical manifestations of Quincke oedema . We report on a patient with necrobiotic xanthogranuloma and myeloma , in whom we found a decreased level of C1 inhibitor and recurrent episodes of manifest Quincke oedema . The indirect detection of auto-antibodies against the paraprotein with development of immune complexes is regarded as an explanation for the consumption of the C1 inactivator and the manifestation of Quincke oedema . The possibility of a causal relationship between paraproteinaemia and necrotic xanthogranuloma is discussed ."
],
"offsets": [
[
0,
781
]
]
}
] |
[
{
"id": "DerHautarzt.40450339.eng.abstr-s1-t1",
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"pathogenesis"
],
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]
],
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"db_id": "C0543483"
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},
{
"id": "DerHautarzt.40450339.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"paraproteinaemia"
],
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[
103,
119
]
],
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{
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"db_id": "C0030489"
}
]
},
{
"id": "DerHautarzt.40450339.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"multiple myeloma"
],
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[
145,
161
]
],
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{
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"db_id": "C0026764"
}
]
},
{
"id": "DerHautarzt.40450339.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"inhibitor"
],
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[
188,
197
]
],
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{
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}
]
},
{
"id": "DerHautarzt.40450339.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"oedema"
],
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[
273,
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]
],
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{
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"db_id": "C0013604"
}
]
},
{
"id": "DerHautarzt.40450339.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"Quincke oedema"
],
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[
265,
279
]
],
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{
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"db_id": "C0002994"
}
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},
{
"id": "DerHautarzt.40450339.eng.abstr-s4-t1",
"type": "umlsterm",
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"patient"
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},
{
"id": "DerHautarzt.40450339.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"inhibitor"
],
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[
393,
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]
],
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{
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}
]
},
{
"id": "DerHautarzt.40450339.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"oedema"
],
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[
446,
452
]
],
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{
"db_name": "UMLS",
"db_id": "C0013604"
}
]
},
{
"id": "DerHautarzt.40450339.eng.abstr-s4-t4",
"type": "umlsterm",
"text": [
"Quincke oedema"
],
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[
438,
452
]
],
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{
"db_name": "UMLS",
"db_id": "C0002994"
}
]
},
{
"id": "DerHautarzt.40450339.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"paraprotein"
],
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[
509,
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]
],
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"db_id": "C0030490"
}
]
},
{
"id": "DerHautarzt.40450339.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"development"
],
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[
526,
537
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0243107"
},
{
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}
]
},
{
"id": "DerHautarzt.40450339.eng.abstr-s5-t3",
"type": "umlsterm",
"text": [
"consumption"
],
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[
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]
],
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{
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"db_id": "C0009830"
}
]
},
{
"id": "DerHautarzt.40450339.eng.abstr-s5-t4",
"type": "umlsterm",
"text": [
"oedema"
],
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[
663,
669
]
],
"normalized": [
{
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"db_id": "C0013604"
}
]
},
{
"id": "DerHautarzt.40450339.eng.abstr-s5-t5",
"type": "umlsterm",
"text": [
"with development"
],
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[
521,
537
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0243107"
}
]
},
{
"id": "DerHautarzt.40450339.eng.abstr-s5-t6",
"type": "umlsterm",
"text": [
"immune complexes"
],
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[
541,
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]
],
"normalized": [
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}
]
},
{
"id": "DerHautarzt.40450339.eng.abstr-s5-t7",
"type": "umlsterm",
"text": [
"C1 inactivator"
],
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[
615,
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]
],
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"db_id": "C0009500"
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]
},
{
"id": "DerHautarzt.40450339.eng.abstr-s5-t8",
"type": "umlsterm",
"text": [
"Quincke oedema"
],
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[
655,
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]
],
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{
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"db_id": "C0002994"
}
]
},
{
"id": "DerHautarzt.40450339.eng.abstr-s6-t1",
"type": "umlsterm",
"text": [
"paraproteinaemia"
],
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[
721,
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]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030489"
}
]
}
] |
[] |
[] |
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DerHautarzt.40450360.eng.abstr
|
DerHautarzt.40450360.eng.abstr
|
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"Abstract . Androgenetic hair loss is the most frequent reason for the topical application of hair-growth-promoting agents . Such preparations should arrest or even reverse androgen-induced hair follicle regression as well as prolonging the hair cycles , especially of the shortened anagen phase , and thus protect from increased hair loss . True evidence of drug effects on hair growth is problematic , since trichograms , the method chiefly applied by the manufacturers , fail to reveal every factor involved in the follicular activity , especially the duration of anagen stage . For example , an increase in the anagen rate does not always reflect a lengthening of the anagen stage , but may also be due to shortened hair cycles . Accordingly , drug effects on hair growth should be investigated by methods that analyse the cell cycle kinetics . For this approach DNA-flowcytometry of the outer root sheath in plucked anagen hairs and of complete anagen hair bulbs taken by micropreparative techniques from scalp biopsies offers a reproducible method for quick and reliable evaluation of hair growth ."
],
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]
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] |
DerHautarzt.40450364.eng.abstr
|
DerHautarzt.40450364.eng.abstr
|
[
{
"id": "DerHautarzt.40450364.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . Contact urticaria and anaphylactic reactions to latex-containing rubber products are being recognized with increasing frequency in all kinds of medical disciplines . Recently a number of reports have been published describing anaphylactic reactions to food items in patients with latex allergy . The cases of three patients who developed anaphylactic reactions to both latex and food items are presented , and the importance of the association of latex and cross-reactivity with food items is stressed . The food items that led to anaphylactic reactions were banana and avocado ; banana , avocado and buckwheat ; and banana , avocado and tomato . The cross-reactivity of latex to buckwheat and tomato has not been reported before ."
],
"offsets": [
[
0,
742
]
]
}
] |
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{
"id": "DerHautarzt.40450364.eng.abstr-s2-t1",
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"urticaria"
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19,
28
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],
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}
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},
{
"id": "DerHautarzt.40450364.eng.abstr-s2-t2",
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"text": [
"rubber"
],
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76,
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]
],
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}
]
},
{
"id": "DerHautarzt.40450364.eng.abstr-s2-t3",
"type": "umlsterm",
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"frequency"
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"id": "DerHautarzt.40450364.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"anaphylactic reactions"
],
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{
"id": "DerHautarzt.40450364.eng.abstr-s3-t1",
"type": "umlsterm",
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"food"
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"id": "DerHautarzt.40450364.eng.abstr-s3-t2",
"type": "umlsterm",
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"patients"
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"id": "DerHautarzt.40450364.eng.abstr-s3-t3",
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{
"id": "DerHautarzt.40450364.eng.abstr-s3-t4",
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"text": [
"allergy"
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{
"id": "DerHautarzt.40450364.eng.abstr-s3-t5",
"type": "umlsterm",
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"anaphylactic reactions"
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},
{
"id": "DerHautarzt.40450364.eng.abstr-s3-t6",
"type": "umlsterm",
"text": [
"latex allergy"
],
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291,
304
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"db_id": "C0577628"
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"id": "DerHautarzt.40450364.eng.abstr-s4-t1",
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"patients"
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"id": "DerHautarzt.40450364.eng.abstr-s4-t2",
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"latex"
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{
"id": "DerHautarzt.40450364.eng.abstr-s4-t3",
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"food"
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},
{
"id": "DerHautarzt.40450364.eng.abstr-s4-t4",
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"association"
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"id": "DerHautarzt.40450364.eng.abstr-s4-t5",
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"id": "DerHautarzt.40450364.eng.abstr-s4-t6",
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"id": "DerHautarzt.40450364.eng.abstr-s4-t7",
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"id": "DerHautarzt.40450364.eng.abstr-s5-t1",
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"food"
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},
{
"id": "DerHautarzt.40450364.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"banana"
],
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570,
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]
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{
"id": "DerHautarzt.40450364.eng.abstr-s5-t3",
"type": "umlsterm",
"text": [
"avocado"
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{
"id": "DerHautarzt.40450364.eng.abstr-s5-t4",
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"text": [
"banana"
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591,
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{
"id": "DerHautarzt.40450364.eng.abstr-s5-t5",
"type": "umlsterm",
"text": [
"avocado"
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600,
607
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},
{
"id": "DerHautarzt.40450364.eng.abstr-s5-t6",
"type": "umlsterm",
"text": [
"buckwheat"
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}
] |
[] |
[] |
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"type": "causes",
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DerHautarzt.40450368.eng.abstr
|
DerHautarzt.40450368.eng.abstr
|
[
{
"id": "DerHautarzt.40450368.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . A follow-up study of 47 patients who had suffered from atopic dermatitis in infancy ( 2 years aged old ) was conducted by means of a questionnaire and personal interview/examination at the mean age of 23 years . It was found that 72.3% of them were still suffering from atopic dermatitis . The atopic eczema was mostly localized on the fingers ( 67.6% ) , on the head , e.g. forehead , eyelids and scalp ( 32% each ) , neck ( 35% ) and chest ( 32% ) . Different localizations from the juvenile and adolescence phase were observed . In 73.5% the lichenoid type of atopic eczema was seen , in 67.6% the eczematic form of reaction , and in 28.4% the follicular form , the latter having decreased significantly in frequency since the adolescent phase . The pruriginous form with prurigo papules was observed only in the 8.8% of the patients who had been suffering from a chronic form of the disease since childhood . Nummular reactions were not observed . In 66% of the patients micromanifestations were present , most frequently perlèches ( 40.4% ) , retroauricular intertrigo ( 34% ) , atopic eyelid eczema ( 21% ) and 21.3% \" pulpite sèche \" ( tylotic , rhagadiform fingerpad eczema ) ( 21.3% ) . In 14.9% of all patients these minimal forms of atopic dermatitis were present exclusively ."
],
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0,
1299
]
]
}
] |
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[] |
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DerHautarzt.40450378.eng.abstr
|
DerHautarzt.40450378.eng.abstr
|
[
{
"id": "DerHautarzt.40450378.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Abstract . We report on an 11-year-old female patient with anhidrotic ectodermal dysplasia ( AED ) showing the following characteristics : ( 1 ) reduced number of hair follicles and incomplete formation of sweat glands ; ( 2 ) disturbed hair growth with shortening of anagen and anhidrosis ; ( 3 ) disturbed cytokeratin expression pattern of CK 13 , 14 , 19 ( follicular epithelium ) and of CK 18 ( eccrine sweat glands ) ; ( 4 ) reduction of cystine and increase in sulphonic cysteine acid . Thus , we demonstrated pathological differentiation on the immunomorphological and on the biochemical level , leading to disturbed keratinization that could be visualized by transmission and scanning electron microscopical studies of the hair shafts . According to these findings AED is a developmental defect that involves not only incomplete formation of hair follicles and sweat glands but also a disordered differentiation and follicular keratinization with disturbed cytokeratin pattern and pathological amino acid composition of the terminal hairs produced ."
],
"offsets": [
[
0,
1057
]
]
}
] |
[
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"female"
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{
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{
"id": "DerHautarzt.40450378.eng.abstr-s2-t3",
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[] |
[] |
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DerHautarzt.40450385.eng.abstr
|
DerHautarzt.40450385.eng.abstr
|
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{
"id": "DerHautarzt.40450385.eng.abstr-passage-0",
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"text": [
"Abstract . Giant cell tumour of the tendon sheath , though rather a common connective tissue tumour , is rarely mentioned in the dermatological literature . It is a benign , slow-growing tumour arising from the synovia and it is most frequently located on the joints of the fingers . It becomes manifest clinically as a firm , skin-coloured nodule fixed to the underlying tissue . The histological picture is characteristic and shows osteoclast-like giant cells , histiocytic cells , foam cells and focal haemosiderosis . It probably reflects a reactive process similar to that of fibrous histiocytoma . The therapy of choice is excision , with a small margin of uninvolved tissue to avoid recurrences ."
],
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[] |
[] |
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DerHautarzt.40450389.eng.abstr
|
DerHautarzt.40450389.eng.abstr
|
[
{
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"text": [
"Abstract . Lupus vulgaris is now a rare dermatological disease . However , in view of the increase in risk factors ( immigration from areas endemic for tuberculosis , multiply drug-resistant strains of Mycobacterium tuberculosis , HIV ) , cutaneous tuberculosis should always be considered in the differential diagnosis . We report on a case of lupus vulgaris vegetans of the nose , which developed by way of autoinoculation of the patient with Mycobacterium tuberculosis from reactivated , pulmonary tuberculosis and responded well to tuberculostatic therapy ."
],
"offsets": [
[
0,
561
]
]
}
] |
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DerHautarzt.40450394.eng.abstr
|
DerHautarzt.40450394.eng.abstr
|
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"Abstract . In anticardiolin syndrome ( ACS ) a typical antibody constellation is associated with thrombotic and hematologic disorders . Furthermore , recurrent abortion , cerebral ischemia and different skin disorders occur . We report the case of a 29-year-old female suffering for the first time from painful , necrotic deep ulcers on the upper and lower legs and livedo racemosa on the arms as a rare example of a merely cutaneous manifestation of ACS with no demonstrable underlying disease . After systemic treatment with high-dose methylprednisolone , azathioprin and hydrocolloid dressings , healing of the scar tissue occurred . Simultaneously , a maintenance dose of acetylsalicylic acid ( 100 mg/day ) was administered . So far , neither cutaneous relapse nor other signs of ACS have occurred ."
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[] |
[] |
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}
] |
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