knowledgator/bio-NER-relations · Datasets at Hugging Face

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DerGynaekologe.90320046.eng.abstr	DerGynaekologe.90320046.eng.abstr	[ { "id": "DerGynaekologe.90320046.eng.abstr-passage-0", "type": "abstract", "text": [ "Hypertensive disorders complicating pregnancy are a major cause of maternal and perinatal morbidity and mortality . Intensive ambulatory obstetric care is likley to achieve a risk reduction with the following topics : early identification of typical signs of preeclampsia , detection of uteroplacental insufficiency and their consequences and early admission to a specialized obstetric care unit or perinatal center . There are no established methods for the prevention of preeclampsia . Women who are at increased risk for having preeclampsia in subsequent pregnancies might be appropriate candidates for low-dose aspirin during pregnancy ; prophylactic calcium supplementation is controversial . To prevent cerebrovascular complications antihypertensive therapy is mandatory . Alpha-Methyl-dopa is the initial drug of choice for oral long-term treatment . In severe preeclampsia continuous monitoring and laboratory evalution of the mother and the fetus are required . Immediate introduction of therapy , including continuous infusion of magnesium sulfate to prevent convulsions , hydralzine to reduce blood pressure and careful volume expansion , is necessary . Under intensive monitoring , prolongation of pregnancy in patients at 25 to 32 weeks ' gestation is reasonable under the following conditions : stable maternal condition , no suspected or manifest DIC and fetal well-being . Immediate delivery is indicated in cases of therapy-refractary severe preeclampsia , imminent eclampsia , after an eclamptic convulsion , and signs of intrauterine fetal asphyxia ." ], "offsets": [ [ 0, 1569 ] ] } ]	[ { "id": "DerGynaekologe.90320046.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "disorders" ], "offsets": [ [ 13, 22 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerGynaekologe.90320046.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "pregnancy" ], "offsets": [ [ 36, 45 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "DerGynaekologe.90320046.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "cause" ], "offsets": [ [ 58, 63 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015127" } ] }, { "id": "DerGynaekologe.90320046.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "morbidity" ], "offsets": [ [ 90, 99 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220880" }, { "db_name": "UMLS", "db_id": "C0026538" } 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"id": "DerGynaekologe.90320046.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "signs" ], "offsets": [ [ 250, 255 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220912" } ] }, { "id": "DerGynaekologe.90320046.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "preeclampsia" ], "offsets": [ [ 259, 271 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032914" } ] }, { "id": "DerGynaekologe.90320046.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "care" ], "offsets": [ [ 386, 390 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0150499" } ] }, { "id": "DerGynaekologe.90320046.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "methods" ], "offsets": [ [ 443, 450 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerGynaekologe.90320046.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "prevention" ], "offsets": [ [ 459, 469 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0687732" } ] }, { "id": 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DerGynaekologe.90320055.eng.abstr	DerGynaekologe.90320055.eng.abstr	[ { "id": "DerGynaekologe.90320055.eng.abstr-passage-0", "type": "abstract", "text": [ "Delivering women gently and safely by avoiding perinatal asphyxia , preterm delivery and ascending intrauterine infection may help to protect babies from cerebral damage during and after birth . The self-determination of women should not be restricted by unnecessary diagnostic and therapeutic interventions . In contrast , obstetricians should cooperate with women to assure an appropriate balance between personal freedom of the mother and safety for the baby during delivery ." ], "offsets": [ [ 0, 479 ] ] } ]	[ { "id": "DerGynaekologe.90320055.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "women" ], "offsets": [ [ 11, 16 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043210" } ] }, { "id": "DerGynaekologe.90320055.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "asphyxia" ], "offsets": [ [ 57, 65 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004044" } ] }, { "id": "DerGynaekologe.90320055.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "delivery" ], "offsets": [ [ 76, 84 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011209" } ] }, { "id": "DerGynaekologe.90320055.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "infection" ], "offsets": [ [ 112, 121 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021311" } ] }, { "id": "DerGynaekologe.90320055.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "babies" ], "offsets": [ [ 142, 148 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021270" } ] }, { "id": "DerGynaekologe.90320055.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "birth" ], "offsets": [ [ 187, 192 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005615" } ] }, { "id": "DerGynaekologe.90320055.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "preterm delivery" ], "offsets": [ [ 68, 84 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0151526" } ] }, { "id": "DerGynaekologe.90320055.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "self-determination" ], "offsets": [ [ 199, 217 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036595" } ] }, { "id": "DerGynaekologe.90320055.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "women" ], "offsets": [ [ 221, 226 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043210" } ] }, { "id": "DerGynaekologe.90320055.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "diagnostic" ], 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DerGynaekologe.90320060.eng.abstr	DerGynaekologe.90320060.eng.abstr	[ { "id": "DerGynaekologe.90320060.eng.abstr-passage-0", "type": "abstract", "text": [ "The routine application of ultrasound in pregnancy has had an important impact on perinatal medicine . New trends in perinatal medicine , aiming at more individual and self-determined pregnancy and delivery , are realizable because of the safety provided by ultrasound . Often prenatal ultrasound is regarded as only being able to detect fetal malformations , but ultrasound provides many more benefits for a safe pregnancy : early detection of fetal viability ; intrauterine localization of the pregnancy ; exact determination of the gestational age in early pregnancy ; later in pregnancy , confirmation of appropriate fetal growth , position and localization of placenta site . In addition , the development of close mother-child bonding by visualizing the fetus could be of positive impact . These aspects are contributions of ultrasound to a gentle and safe pregnancy and delivery for mother and child ." ], "offsets": [ [ 0, 908 ] ] } ]	[ { "id": "DerGynaekologe.90320060.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "ultrasound" ], "offsets": [ [ 27, 37 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220934" }, { "db_name": "UMLS", "db_id": "C0041618" }, { "db_name": "UMLS", "db_id": "C0041621" } ] }, { "id": "DerGynaekologe.90320060.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "pregnancy" ], "offsets": [ [ 41, 50 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "DerGynaekologe.90320060.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "medicine" ], "offsets": [ [ 92, 100 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025118" }, { "db_name": "UMLS", "db_id": "C0013227" } ] }, { "id": "DerGynaekologe.90320060.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "trends" ], "offsets": [ [ 107, 113 ] ], "normalized": [ { "db_name": 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"db_id": "C0036043" } ] }, { "id": "DerGynaekologe.90320060.eng.abstr-s2-t7", "type": "umlsterm", "text": [ "ultrasound" ], "offsets": [ [ 258, 268 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220934" }, { "db_name": "UMLS", "db_id": "C0041618" }, { "db_name": "UMLS", "db_id": "C0041621" } ] }, { "id": "DerGynaekologe.90320060.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "ultrasound" ], "offsets": [ [ 286, 296 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220934" }, { "db_name": "UMLS", "db_id": "C0041618" }, { "db_name": "UMLS", "db_id": "C0041621" } ] }, { "id": "DerGynaekologe.90320060.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "malformations" ], "offsets": [ [ 344, 357 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000768" }, { "db_name": "UMLS", "db_id": "C0243070" } ] }, { "id": "DerGynaekologe.90320060.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "ultrasound" ], "offsets": [ [ 364, 374 ] ], "normalized": [ { "db_name": "UMLS", "db_id": 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We present the variety of intraglandular techniques and local flaps that enable the breast surgeon to achieve good symmetry and breast shape with minimal surgery and scarring ." ], "offsets": [ [ 0, 767 ] ] } ]	[ { "id": "DerGynaekologe.90320083.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "surgical" ], "offsets": [ [ 30, 38 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "DerGynaekologe.90320083.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 39, 48 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerGynaekologe.90320083.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "breast" ], "offsets": [ [ 52, 58 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006141" }, { "db_name": "UMLS", "db_id": "C0006142" } ] }, { "id": "DerGynaekologe.90320083.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "cancer" ], "offsets": [ [ 59, 65 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006826" } ] }, { "id": "DerGynaekologe.90320083.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "prognosis" ], "offsets": [ [ 111, 120 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033325" } ] }, { "id": "DerGynaekologe.90320083.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "recurrence" ], "offsets": [ [ 131, 141 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034897" } ] }, { "id": "DerGynaekologe.90320083.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "standard" ], "offsets": [ [ 167, 175 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038137" }, { "db_name": "UMLS", "db_id": "C0175675" } ] }, { "id": "DerGynaekologe.90320083.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "procedures" ], "offsets": [ [ 194, 204 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0184661" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerGynaekologe.90320083.eng.abstr-s1-t9", "type": "umlsterm", "text": [ "surgical treatment" ], 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In cases where breast-conserving surgery is feasible , partial or modified radical mastectomy can be followed by autogenous tissue reconstruction with TRAM or latissimus dorsi flaps . Because of their safety and versatility , latissimus dorsi musculocutaneous flaps are currently making a remarkable comeback ." ], "offsets": [ [ 0, 1045 ] ] } ]	[ { "id": "DerGynaekologe.90320091.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Carcinoma" ], "offsets": [ [ 0, 9 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007097" } ] }, { "id": "DerGynaekologe.90320091.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "breast" ], "offsets": [ [ 17, 23 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006141" }, { "db_name": "UMLS", "db_id": "C0006142" } ] }, { "id": "DerGynaekologe.90320091.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "malignancy" ], "offsets": [ [ 45, 55 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006826" } ] }, { "id": "DerGynaekologe.90320091.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "woman" ], "offsets": [ [ 59, 64 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043210" } ] }, { "id": "DerGynaekologe.90320091.eng.abstr-s2-t1", 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Immediate reconstruction following carcinoma extends the individual spectrum of treatment options with reference to primary treatment tailored to the tumour and is characterized by the decisive quality criterion of subsequent freedom from local recurrence ." ], "offsets": [ [ 0, 813 ] ] } ]	[ { "id": "DerGynaekologe.90320098.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "breast" ], "offsets": [ [ 10, 16 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006141" }, { "db_name": "UMLS", "db_id": "C0006142" } ] }, { "id": "DerGynaekologe.90320098.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 65, 73 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerGynaekologe.90320098.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "mastectomy" ], "offsets": [ [ 85, 95 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024881" }, { "db_name": "UMLS", "db_id": "C0024886" } ] }, { "id": "DerGynaekologe.90320098.eng.abstr-s1-t4", "type": 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Other advantages are the reduction of breast size and therefore target volume before postoperative radiation procedures as well as in cancer prophylaxis and risk reduction by reducing ipsi- and contralateral breast tissue . Reduction mammoplasty techniques with different resection areas have to be selected for individual tumor locations . The best symmetry is achieved by bilateral mammoplasty in a one step procedure with lumpectomy and axillary dissection . Oncoplastic or reconstructive surgery in the target breast is often followed by procedures to improve symmetry by contralateral reduction . Whenever possible , mammoplasty techniques with minimal scarring should be chosen out of a variety of reduction procedures ." ], "offsets": [ [ 0, 1405 ] ] } ]	[ { "id": "DerGynaekologe.90320106.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "mastectomy" ], "offsets": [ [ 37, 47 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024881" }, { "db_name": "UMLS", "db_id": "C0024886" } ] }, { "id": "DerGynaekologe.90320106.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "breast" ], "offsets": [ [ 52, 58 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006141" }, { "db_name": "UMLS", "db_id": "C0006142" } ] }, { "id": "DerGynaekologe.90320106.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "cancer" ], "offsets": [ [ 59, 65 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006826" } ] }, { "id": "DerGynaekologe.90320106.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "breast cancer" ], "offsets": [ [ 52, 65 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006142" } ] }, { "id": "DerGynaekologe.90320106.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "use" ], "offsets": [ [ 105, 108 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042153" } ] }, { "id": "DerGynaekologe.90320106.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "plastic" ], "offsets": [ [ 112, 119 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032167" } ] }, { "id": "DerGynaekologe.90320106.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "techniques" ], "offsets": [ [ 135, 145 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerGynaekologe.90320106.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 185, 192 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerGynaekologe.90320106.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "breast" ], "offsets": [ [ 208, 214 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006141" }, { "db_name": "UMLS", "db_id": "C0006142" } ] }, { "id": "DerGynaekologe.90320106.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "tumors" ], "offsets": [ [ 215, 221 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerGynaekologe.90320106.eng.abstr-s2-t7", "type": "umlsterm", "text": [ "cosmetic" ], "offsets": [ [ 237, 245 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010164" } ] }, { "id": "DerGynaekologe.90320106.eng.abstr-s2-t8", "type": "umlsterm", "text": [ "safety" ], "offsets": [ [ 270, 276 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036043" } ] }, { "id": "DerGynaekologe.90320106.eng.abstr-s2-t9", "type": "umlsterm", "text": [ "breast tumors" ], "offsets": [ [ 208, 221 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006149" } ] }, { "id": "DerGynaekologe.90320106.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "breast-to-tumor" ], "offsets": [ [ 283, 298 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006141" }, { "db_name": "UMLS", "db_id": "C0006142" } ] }, { "id": "DerGynaekologe.90320106.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "breast-to-tumor" ], "offsets": [ [ 283, 298 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerGynaekologe.90320106.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "tumor" ], "offsets": [ [ 346, 351 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerGynaekologe.90320106.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "surgery" ], "offsets": [ [ 422, 429 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038894" }, { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "DerGynaekologe.90320106.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "breast-conserving surgery" ], "offsets": [ [ 404, 429 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0917927" } ] }, { "id": "DerGynaekologe.90320106.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "techniques" ], "offsets": [ [ 442, 452 ] ], "normalized": [ { "db_name": "UMLS", 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DerGynaekologe.90320121.eng.abstr	DerGynaekologe.90320121.eng.abstr	[ { "id": "DerGynaekologe.90320121.eng.abstr-passage-0", "type": "abstract", "text": [ "Reconstruction of the vulva and vagina is mandatory in gynecological surgery . Any gynecologist should be familiar with the different surgical options and should know which center is most appropriate to refer the patient . Careful operative techniques and intensive perioperative management are decisive for good healing results . An optimal anatomic and functional outcome is part of global psychosomatic treatment ." ], "offsets": [ [ 0, 417 ] ] } ]	[ { "id": "DerGynaekologe.90320121.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "vulva" ], "offsets": [ [ 22, 27 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042993" }, { "db_name": "UMLS", "db_id": "C0375071" } ] }, { "id": "DerGynaekologe.90320121.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "vagina" ], "offsets": [ [ 32, 38 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042251" }, { "db_name": "UMLS", "db_id": "C0042232" } ] }, { "id": "DerGynaekologe.90320121.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "surgery" ], "offsets": [ [ 69, 76 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038894" }, { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "DerGynaekologe.90320121.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "gynecological surgery" ], "offsets": [ [ 55, 76 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038902" } ] }, { "id": "DerGynaekologe.90320121.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "surgical" ], "offsets": [ [ 134, 142 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "DerGynaekologe.90320121.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 213, 220 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerGynaekologe.90320121.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "techniques" ], "offsets": [ [ 241, 251 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerGynaekologe.90320121.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "anatomic" ], "offsets": [ [ 342, 350 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220784" } ] }, { "id": "DerGynaekologe.90320121.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 406, 415 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] } ]	[]	[]	[ { "id": "DerGynaekologe.90320121.eng.abstr-s1-r1-t1.2-t3.2", "type": "associated_with", "arg1_id": "DerGynaekologe.90320121.eng.abstr-s1-t1", "arg2_id": "DerGynaekologe.90320121.eng.abstr-s1-t3", "normalized": [] }, { "id": "DerGynaekologe.90320121.eng.abstr-s1-r2-t2.2-t1.2", "type": "location_of", "arg1_id": "DerGynaekologe.90320121.eng.abstr-s4-t2", "arg2_id": "DerGynaekologe.90320121.eng.abstr-s1-t1", "normalized": [] }, { "id": "DerGynaekologe.90320121.eng.abstr-s1-r4-t1.1-t1.2", "type": "location_of", "arg1_id": "DerGynaekologe.90320121.eng.abstr-s4-t1", "arg2_id": "DerGynaekologe.90320121.eng.abstr-s1-t1", "normalized": [] }, { "id": "DerGynaekologe.90320121.eng.abstr-s1-r5-t2.2-t3.2", "type": "location_of", "arg1_id": "DerGynaekologe.90320121.eng.abstr-s4-t2", "arg2_id": "DerGynaekologe.90320121.eng.abstr-s1-t3", "normalized": [] }, { "id": "DerGynaekologe.90320121.eng.abstr-s1-r6-t1.1-t3.1", "type": "issue_in", "arg1_id": "DerGynaekologe.90320121.eng.abstr-s4-t1", "arg2_id": "DerGynaekologe.90320121.eng.abstr-s1-t3", "normalized": [] }, { "id": "DerGynaekologe.90320121.eng.abstr-s1-r7-t1.2-t3.1", "type": "issue_in", "arg1_id": "DerGynaekologe.90320121.eng.abstr-s1-t1", "arg2_id": "DerGynaekologe.90320121.eng.abstr-s1-t3", "normalized": [] }, { "id": "DerGynaekologe.90320121.eng.abstr-s1-r8-t1.1-t3.2", "type": "location_of", "arg1_id": "DerGynaekologe.90320121.eng.abstr-s4-t1", "arg2_id": "DerGynaekologe.90320121.eng.abstr-s1-t3", "normalized": [] }, { "id": "DerGynaekologe.90320121.eng.abstr-s1-r9-t3.2-t1.2", "type": "associated_with", "arg1_id": "DerGynaekologe.90320121.eng.abstr-s1-t3", "arg2_id": "DerGynaekologe.90320121.eng.abstr-s1-t1", "normalized": [] }, { "id": "DerGynaekologe.90320121.eng.abstr-s1-r11-t2.2-t3.1", "type": "issue_in", "arg1_id": "DerGynaekologe.90320121.eng.abstr-s4-t2", "arg2_id": "DerGynaekologe.90320121.eng.abstr-s1-t3", "normalized": [] } ]
DerGynaekologe.90320169.eng.abstr	DerGynaekologe.90320169.eng.abstr	[ { "id": "DerGynaekologe.90320169.eng.abstr-passage-0", "type": "abstract", "text": [ "With the high-resolution ultrasound technology available today , the rapid embryofetal development during the first trimester can be imaged in detail . Thus , malformations can also be recognized if especially searched for . In the literature an enormous number of ultrasonographic normal values concerning early pregnancy have been published , and there are innumerable case reports of early diagnosed malformations of various organ systems . With a targeted search more than half of anomalies detectable in the second trimester can be seen at the end of the first trimester . These data , however , are insufficient to justify the introduction of early screening for fetal anomalies . With a burdened history a targeted exclusion diagnosis can contribute to the first psychological relief of the parents . If there are abnormal findings , in many cases the prognosis can not be ascertained and some anomalies appear only temporarily in later healthy children . Therefore , hasty conclusions should be avoided ." ], "offsets": [ [ 0, 1012 ] ] } ]	[ { "id": "DerGynaekologe.90320169.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "ultrasound" ], "offsets": [ [ 25, 35 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220934" }, { "db_name": "UMLS", "db_id": "C0041618" }, { "db_name": "UMLS", "db_id": "C0041621" } ] }, { "id": "DerGynaekologe.90320169.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "technology" ], "offsets": [ [ 36, 46 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039421" } ] }, { "id": "DerGynaekologe.90320169.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "embryofetal" ], "offsets": [ [ 75, 86 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013935" } ] }, { "id": "DerGynaekologe.90320169.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "development" ], "offsets": [ [ 87, 98 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243107" }, { "db_name": "UMLS", "db_id": "C0020119" } ] }, { "id": "DerGynaekologe.90320169.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "first trimester" ], "offsets": [ [ 110, 125 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032979" } ] }, { "id": "DerGynaekologe.90320169.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "malformations" ], "offsets": [ [ 159, 172 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000768" }, { "db_name": "UMLS", "db_id": "C0243070" } ] }, { "id": "DerGynaekologe.90320169.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "literature" ], "offsets": [ [ 232, 242 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023866" } ] }, { "id": "DerGynaekologe.90320169.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "values" ], "offsets": [ [ 289, 295 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042295" } ] }, { "id": "DerGynaekologe.90320169.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "pregnancy" ], "offsets": [ [ 313, 322 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": 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Based on normal sonoembryology and on recent experiences with early CNS anomalies , we recognize some sonographic signs of an early CNS anomaly : ( 1 ) Apparent dysmorphology of the brain or the head ; ( 2 ) Altered appearance of the cerebral ventricles with disproportion of the brain compartments , where the amount of fluid is either greater or less than normal ; ( 3 ) In the early fetal period , choroid plexuses that are too small to fill the ventricle from the medial to the lateral wall ; ( 4 ) Irregular contour of the spine/back ; ( 5 ) Extra-CNS anomalies . In the following survey , normal sonoembryology of the CNS is described , and CNS anomalies of the early pregnancy are discussed ." ], "offsets": [ [ 0, 1271 ] ] } ]	[ { "id": "DerGynaekologe.90320181.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "development" ], "offsets": [ [ 12, 23 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243107" }, { "db_name": "UMLS", "db_id": "C0020119" } ] }, { "id": "DerGynaekologe.90320181.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "human" ], "offsets": [ [ 31, 36 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020114" } ] }, { "id": "DerGynaekologe.90320181.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "embryo" ], "offsets": [ [ 37, 43 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013935" } ] }, { "id": "DerGynaekologe.90320181.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "human" ], "offsets": [ [ 70, 75 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020114" } ] }, { "id": "DerGynaekologe.90320181.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "embryology" ], "offsets": [ [ 76, 86 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013942" }, { "db_name": "UMLS", "db_id": "C0013943" } ] }, { "id": "DerGynaekologe.90320181.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "brain" ], "offsets": [ [ 169, 174 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0153633" }, { "db_name": "UMLS", "db_id": "C0006104" }, { "db_name": "UMLS", "db_id": "C0496899" } ] }, { "id": "DerGynaekologe.90320181.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "ultrasound" ], "offsets": [ [ 204, 214 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220934" }, { "db_name": "UMLS", "db_id": "C0041618" }, { "db_name": "UMLS", "db_id": "C0041621" } ] }, { "id": "DerGynaekologe.90320181.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "brain" ], "offsets": [ [ 274, 279 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0153633" }, { "db_name": "UMLS", "db_id": "C0006104" }, { "db_name": "UMLS", "db_id": "C0496899" } ] }, { "id": "DerGynaekologe.90320181.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "anatomy" ], "offsets": [ [ 354, 361 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220784" }, { "db_name": "UMLS", "db_id": "C0002808" } ] }, { "id": "DerGynaekologe.90320181.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "development" ], "offsets": [ [ 424, 435 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243107" }, { "db_name": "UMLS", "db_id": "C0020119" } ] }, { "id": "DerGynaekologe.90320181.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "abnormalities" ], "offsets": [ [ 450, 463 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000768" }, { "db_name": "UMLS", "db_id": "C0000769" } ] }, { "id": "DerGynaekologe.90320181.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "congenital" ], "offsets": [ [ 497, 507 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009678" } ] }, { "id": "DerGynaekologe.90320181.eng.abstr-s4-t2", "type": 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The latter may be due to a gene dosage effect of the three rather than the normal two copies of genes found in trisomies , causing an alteration of the extracellular matrix in the skin or abnormal development of the heart and great arteries ." ], "offsets": [ [ 0, 848 ] ] } ]	[ { "id": "DerGynaekologe.90320193.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "fetuses" ], "offsets": [ [ 17, 24 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015965" } ] }, { "id": "DerGynaekologe.90320193.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "syndrome" ], "offsets": [ [ 65, 73 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "DerGynaekologe.90320193.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "neck" ], "offsets": [ [ 123, 127 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027530" } ] }, { "id": "DerGynaekologe.90320193.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "Turner syndrome" ], "offsets": [ [ 58, 73 ] ], "normalized": [ { "db_name": "UMLS", 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The clinical prenatal management options for parents regarding the early detection of high-risk groups and the detection of fetal anomalies are discussed ." ], "offsets": [ [ 0, 804 ] ] } ]	[ { "id": "DerGynaekologe.90320200.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "use" ], "offsets": [ [ 34, 37 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042153" } ] }, { "id": "DerGynaekologe.90320200.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "ultrasound" ], "offsets": [ [ 47, 57 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220934" }, { "db_name": "UMLS", "db_id": "C0041618" }, { "db_name": "UMLS", "db_id": "C0041621" } ] }, { "id": "DerGynaekologe.90320200.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "fetal ultrasound" ], "offsets": [ [ 41, 57 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162502" } ] }, { "id": "DerGynaekologe.90320200.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "first trimester" ], "offsets": [ [ 65, 80 ] ], "normalized": [ { "db_name": 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DerGynaekologe.90320213.eng.abstr	DerGynaekologe.90320213.eng.abstr	[ { "id": "DerGynaekologe.90320213.eng.abstr-passage-0", "type": "abstract", "text": [ "Three-dimensional imaging with the capacity for automatic data acquisition and volume storage provides the possibility of analyzing structures tomographically in certain steps . Sectional planes that cannot be demonstrated by conventional ultrasound can be calculated and displayed from the volume memory . In addition , three-dimensional images may be calculated using the surface and transparent mode . With those different viewing modes and permanent storage of the acquired volumes , the transvaginal 3-D technique offers a precise diagnosis in early pregnancy ." ], "offsets": [ [ 0, 566 ] ] } ]	[ { "id": "DerGynaekologe.90320213.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "imaging" ], "offsets": [ [ 18, 25 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011923" } ] }, { "id": "DerGynaekologe.90320213.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "Three-dimensional imaging" ], "offsets": [ [ 0, 25 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0887832" } ] }, { "id": "DerGynaekologe.90320213.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "ultrasound" ], "offsets": [ [ 239, 249 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220934" }, { "db_name": "UMLS", "db_id": "C0041618" }, { "db_name": "UMLS", "db_id": "C0041621" } ] }, { "id": "DerGynaekologe.90320213.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "memory" ], "offsets": [ [ 298, 304 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025260" } ] }, { "id": "DerGynaekologe.90320213.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "three-dimensional images" ], "offsets": [ [ 321, 345 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0917888" } ] }, { "id": "DerGynaekologe.90320213.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "technique" ], "offsets": [ [ 509, 518 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerGynaekologe.90320213.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "diagnosis" ], "offsets": [ [ 536, 545 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011900" }, { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerGynaekologe.90320213.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "pregnancy" ], "offsets": [ [ 555, 564 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] } ]	[]	[]	[ { "id": "DerGynaekologe.90320213.eng.abstr-s2-r1-t1.1-t1.3", "type": "measures", "arg1_id": "DerGynaekologe.90320213.eng.abstr-s4-t1", "arg2_id": "DerGynaekologe.90320213.eng.abstr-s2-t1", "normalized": [] }, { "id": "DerGynaekologe.90320213.eng.abstr-s2-r2-t1.3-t2.1", "type": "result_of", "arg1_id": "DerGynaekologe.90320213.eng.abstr-s2-t1", "arg2_id": "DerGynaekologe.90320213.eng.abstr-s4-t2", "normalized": [] }, { "id": "DerGynaekologe.90320213.eng.abstr-s2-r3-t1.1-t2.1", "type": "result_of", "arg1_id": "DerGynaekologe.90320213.eng.abstr-s4-t1", "arg2_id": "DerGynaekologe.90320213.eng.abstr-s4-t2", "normalized": [] }, { "id": "DerGynaekologe.90320213.eng.abstr-s2-r4-t2.1-t1.3", "type": "result_of", "arg1_id": "DerGynaekologe.90320213.eng.abstr-s4-t2", "arg2_id": "DerGynaekologe.90320213.eng.abstr-s2-t1", "normalized": [] }, { "id": "DerGynaekologe.90320213.eng.abstr-s2-r5-t1.1-t2.1", "type": "measures", "arg1_id": "DerGynaekologe.90320213.eng.abstr-s4-t1", "arg2_id": "DerGynaekologe.90320213.eng.abstr-s4-t2", "normalized": [] }, { "id": "DerGynaekologe.90320213.eng.abstr-s4-r1-t1.1-t2.2", "type": "measures", "arg1_id": "DerGynaekologe.90320213.eng.abstr-s4-t1", "arg2_id": "DerGynaekologe.90320213.eng.abstr-s4-t2", "normalized": [] } ]
DerGynaekologe.90320220.eng.abstr	DerGynaekologe.90320220.eng.abstr	[ { "id": "DerGynaekologe.90320220.eng.abstr-passage-0", "type": "abstract", "text": [ "Transvaginal ultrasound provides an early and accurate technique to assess first trimester pregnancy . Beginning with the demonstration of an intrauterine gestational sac , sonography enables further evaluation of normal pregnancy development , such as identification of the embryo , visualization of the yolk sac , and the presence of fetal cardiac activity as a reassurance of fetal viability . Furthermore it allows closed sonographic monitoring of early intrauterine pregnancy and distinction between normal and abnormal development of pregnancy . A prediction in terms of pregnancy outcome can be made regarding pregnancy complications or specific risks like vaginal bleeding , the demonstration of intrauterine hematoma , advanced maternal age , early growth delay or fetal bradycardia ." ], "offsets": [ [ 0, 793 ] ] } ]	[ { "id": "DerGynaekologe.90320220.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "ultrasound" ], "offsets": [ [ 13, 23 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220934" }, { "db_name": "UMLS", "db_id": "C0041618" }, { "db_name": "UMLS", "db_id": "C0041621" } ] }, { "id": "DerGynaekologe.90320220.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "technique" ], "offsets": [ [ 55, 64 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerGynaekologe.90320220.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "pregnancy" ], "offsets": [ [ 91, 100 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "DerGynaekologe.90320220.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "first trimester" ], "offsets": [ [ 75, 90 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032979" } ] }, { "id": "DerGynaekologe.90320220.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "first trimester pregnancy" ], "offsets": [ [ 75, 100 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032979" } ] }, { "id": "DerGynaekologe.90320220.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "sonography" ], "offsets": [ [ 173, 183 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0041618" } ] }, { "id": "DerGynaekologe.90320220.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "evaluation" ], "offsets": [ [ 200, 210 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220825" } ] }, { "id": "DerGynaekologe.90320220.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "pregnancy" ], "offsets": [ [ 221, 230 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "DerGynaekologe.90320220.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "development" ], "offsets": [ [ 231, 242 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243107" }, { "db_name": "UMLS", "db_id": "C0020119" } ] }, { "id": "DerGynaekologe.90320220.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "identification" ], "offsets": [ [ 253, 267 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020792" } ] }, { "id": "DerGynaekologe.90320220.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "embryo" ], "offsets": [ [ 275, 281 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013935" } ] }, { "id": "DerGynaekologe.90320220.eng.abstr-s2-t7", "type": "umlsterm", "text": [ "visualization" ], "offsets": [ [ 284, 297 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0150627" } ] }, { "id": "DerGynaekologe.90320220.eng.abstr-s2-t8", "type": "umlsterm", "text": [ "viability" ], "offsets": [ [ 385, 394 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376314" } ] }, { "id": "DerGynaekologe.90320220.eng.abstr-s2-t9", "type": "umlsterm", "text": [ "yolk sac" ], "offsets": [ [ 305, 313 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043425" } ] }, { "id": "DerGynaekologe.90320220.eng.abstr-s2-t10", "type": "umlsterm", "text": [ "fetal viability" ], "offsets": [ [ 379, 394 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015954" } ] }, { "id": "DerGynaekologe.90320220.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "pregnancy" ], "offsets": [ [ 471, 480 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "DerGynaekologe.90320220.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "development" ], "offsets": [ [ 525, 536 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243107" }, { "db_name": "UMLS", "db_id": "C0020119" } ] }, { "id": "DerGynaekologe.90320220.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "pregnancy" ], "offsets": [ [ 540, 549 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "DerGynaekologe.90320220.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "abnormal 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"type": "associated_with", "arg1_id": "DerGynaekologe.90320220.eng.abstr-s4-t5", "arg2_id": "DerGynaekologe.90320220.eng.abstr-s4-t7", "normalized": [] }, { "id": "DerGynaekologe.90320220.eng.abstr-s4-r43-t5.1-t1.1", "type": "evaluation_of", "arg1_id": "DerGynaekologe.90320220.eng.abstr-s4-t5", "arg2_id": "DerGynaekologe.90320220.eng.abstr-s4-t1", "normalized": [] } ]
DerGynaekologe.90320247.eng.abstr	DerGynaekologe.90320247.eng.abstr	[ { "id": "DerGynaekologe.90320247.eng.abstr-passage-0", "type": "abstract", "text": [ "Molecular and epidemiological studies have confirmed that human pathogenic papillomaviruses ( HPV ) types 16 and 18 are causally involved in the developement of carcinoma of the cervix . This statement is also true , albeit with reservations as yet , of other so-called high-risk HPV types , such as HPV 31 , 33 , 35 , 39 , 45 , 51 , 52 , 56 and 58. Around 500,000 women throughout the world become ill with carcinoma of the cervix every year , and 1-4% of all younger women have a precancer of the cervix uteri . This knowledge of the viral origin of anogenital neoplasms has not yet been exploited for primary and secondary prevention of these illnesses , however . This is mainly because infection with genital HPV types is very prevalent in young women but seldom leads to carcinoma . In this review , therefore , the most important epidemiological data available on cervical carcinoma and its preliminary stages are analysed with reference to an association with HPV . In addition , the molecular biological data on HPV as it relates to anogenital carcinogenesis are presented . In conclusion , the significance of HPV for the prevention of carcinoma of the cervix is discussed ." ], "offsets": [ [ 0, 1184 ] ] } ]	[ { "id": "DerGynaekologe.90320247.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "human" ], "offsets": [ [ 58, 63 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020114" } ] }, { "id": "DerGynaekologe.90320247.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "papillomaviruses" ], "offsets": [ [ 75, 91 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030354" }, { "db_name": "UMLS", "db_id": "C0030358" } ] }, { "id": "DerGynaekologe.90320247.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "HPV" ], "offsets": [ [ 94, 97 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021344" } ] }, { "id": "DerGynaekologe.90320247.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "carcinoma" ], "offsets": [ [ 161, 170 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007097" } ] }, { "id": "DerGynaekologe.90320247.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "cervix" ], "offsets": [ [ 178, 184 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007874" } ] }, { "id": "DerGynaekologe.90320247.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "epidemiological studies" ], "offsets": [ [ 14, 37 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002783" } ] }, { "id": "DerGynaekologe.90320247.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "HPV" ], "offsets": [ [ 280, 283 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021344" } ] }, { "id": "DerGynaekologe.90320247.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "HPV" ], "offsets": [ [ 300, 303 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021344" } ] }, { "id": "DerGynaekologe.90320247.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "women" ], "offsets": [ [ 365, 370 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043210" } ] }, { "id": "DerGynaekologe.90320247.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "carcinoma" ], "offsets": [ [ 408, 417 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007097" } ] }, { "id": "DerGynaekologe.90320247.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "cervix" ], "offsets": [ [ 425, 431 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007874" } ] }, { "id": "DerGynaekologe.90320247.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "women" ], "offsets": [ [ 469, 474 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043210" } ] }, { "id": "DerGynaekologe.90320247.eng.abstr-s2-t7", "type": "umlsterm", "text": [ "precancer" ], "offsets": [ [ 482, 491 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006826" } ] }, { "id": "DerGynaekologe.90320247.eng.abstr-s2-t8", "type": "umlsterm", "text": [ "cervix" ], "offsets": [ [ 499, 505 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007874" } ] }, { "id": "DerGynaekologe.90320247.eng.abstr-s2-t9", "type": "umlsterm", "text": [ "uteri" ], "offsets": [ [ 506, 511 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042131" }, { "db_name": "UMLS", "db_id": "C0042149" } ] }, { "id": "DerGynaekologe.90320247.eng.abstr-s2-t10", "type": "umlsterm", "text": [ "cervix uteri" ], "offsets": [ [ 499, 511 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007847" }, { "db_name": "UMLS", "db_id": "C0007874" } ] }, { "id": "DerGynaekologe.90320247.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "knowledge" ], "offsets": [ [ 519, 528 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376554" } ] }, { "id": "DerGynaekologe.90320247.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "viral" ], "offsets": [ [ 536, 541 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0521026" } ] }, { "id": "DerGynaekologe.90320247.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "origin" ], "offsets": [ [ 542, 548 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0079946" } ] }, { "id": "DerGynaekologe.90320247.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "neoplasms" ], "offsets": [ [ 563, 572 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" }, { "db_name": "UMLS", "db_id": "C0036210" } ] }, { "id": "DerGynaekologe.90320247.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "secondary" ], "offsets": [ [ 616, 625 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027627" }, { "db_name": "UMLS", "db_id": "C0036525" } ] }, { "id": "DerGynaekologe.90320247.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "prevention" ], "offsets": [ [ 626, 636 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0687732" } ] }, { "id": "DerGynaekologe.90320247.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "infection" ], "offsets": [ [ 691, 700 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021311" } ] }, { "id": "DerGynaekologe.90320247.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "HPV" ], "offsets": [ [ 714, 717 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021344" } ] }, { "id": "DerGynaekologe.90320247.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "women" ], "offsets": [ [ 751, 756 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043210" } ] }, { "id": "DerGynaekologe.90320247.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "carcinoma" ], "offsets": [ [ 777, 786 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007097" } ] }, { "id": "DerGynaekologe.90320247.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "review" ], "offsets": [ [ 797, 803 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0282443" } ] }, { "id": "DerGynaekologe.90320247.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "carcinoma" ], "offsets": [ [ 880, 889 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007097" } ] }, { "id": "DerGynaekologe.90320247.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "stages" ], "offsets": [ [ 910, 916 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027646" } ] }, { "id": "DerGynaekologe.90320247.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "association" ], "offsets": [ [ 951, 962 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004083" } ] }, { "id": "DerGynaekologe.90320247.eng.abstr-s5-t5", "type": "umlsterm", "text": [ "HPV" ], "offsets": [ [ 968, 971 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021344" } ] }, { "id": "DerGynaekologe.90320247.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "HPV" ], "offsets": [ [ 1021, 1024 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021344" } ] }, { "id": "DerGynaekologe.90320247.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "HPV" ], "offsets": [ [ 1120, 1123 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021344" } ] }, { "id": "DerGynaekologe.90320247.eng.abstr-s7-t2", "type": "umlsterm", "text": [ "prevention" ], "offsets": [ [ 1132, 1142 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0687732" } ] }, { "id": "DerGynaekologe.90320247.eng.abstr-s7-t3", "type": "umlsterm", "text": [ "carcinoma" ], "offsets": [ [ 1146, 1155 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007097" } ] }, { "id": "DerGynaekologe.90320247.eng.abstr-s7-t4", "type": "umlsterm", "text": [ "cervix" ], "offsets": [ [ 1163, 1169 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007874" } ] } ]	[]	[]	[ { "id": "DerGynaekologe.90320247.eng.abstr-s1-r1-t2.2-t4.1", "type": "causes", "arg1_id": "DerGynaekologe.90320247.eng.abstr-s1-t2", "arg2_id": "DerGynaekologe.90320247.eng.abstr-s7-t4", "normalized": [] }, { "id": "DerGynaekologe.90320247.eng.abstr-s1-r2-t2.2-t1.1", "type": "causes", "arg1_id": "DerGynaekologe.90320247.eng.abstr-s1-t2", "arg2_id": "DerGynaekologe.90320247.eng.abstr-s7-t1", "normalized": [] }, { "id": "DerGynaekologe.90320247.eng.abstr-s1-r3-t3.1-t4.1", "type": "causes", "arg1_id": "DerGynaekologe.90320247.eng.abstr-s7-t3", "arg2_id": "DerGynaekologe.90320247.eng.abstr-s7-t4", "normalized": [] }, { "id": "DerGynaekologe.90320247.eng.abstr-s1-r4-t3.1-t1.1", "type": "causes", "arg1_id": "DerGynaekologe.90320247.eng.abstr-s7-t3", "arg2_id": "DerGynaekologe.90320247.eng.abstr-s7-t1", "normalized": [] }, { "id": "DerGynaekologe.90320247.eng.abstr-s1-r5-t4.1-t1.1", "type": "affects", "arg1_id": "DerGynaekologe.90320247.eng.abstr-s7-t4", "arg2_id": "DerGynaekologe.90320247.eng.abstr-s7-t1", "normalized": [] }, { "id": "DerGynaekologe.90320247.eng.abstr-s1-r6-t1.1-t2.2", "type": "affects", "arg1_id": "DerGynaekologe.90320247.eng.abstr-s7-t1", "arg2_id": "DerGynaekologe.90320247.eng.abstr-s1-t2", "normalized": [] }, { "id": "DerGynaekologe.90320247.eng.abstr-s1-r7-t2.2-t1.1", "type": "interacts_with", "arg1_id": "DerGynaekologe.90320247.eng.abstr-s1-t2", "arg2_id": "DerGynaekologe.90320247.eng.abstr-s7-t1", "normalized": [] }, { "id": "DerGynaekologe.90320247.eng.abstr-s1-r8-t1.1-t3.1", "type": "affects", "arg1_id": "DerGynaekologe.90320247.eng.abstr-s7-t1", "arg2_id": "DerGynaekologe.90320247.eng.abstr-s7-t3", "normalized": [] }, { "id": "DerGynaekologe.90320247.eng.abstr-s1-r9-t3.1-t1.1", "type": "interacts_with", "arg1_id": "DerGynaekologe.90320247.eng.abstr-s7-t3", "arg2_id": 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DerGynaekologe.90320273.eng.abstr	DerGynaekologe.90320273.eng.abstr	[ { "id": "DerGynaekologe.90320273.eng.abstr-passage-0", "type": "abstract", "text": [ "Laparoscopic procedures have attained increasing importance in the diagnosis and therapy of carcinoma of the cervix in recent years ( Table 1 ) [ 34 ] . Laparoscopic pelvic and para-aortal lymphadenectomies are therefore performed to assess the operability of carcinoma of the cervix and for its staging . In the case of primarily operable tumours , paraortal and pelvic lymphadenectomy is carried out by a laparoscopic procedure , and when the lymph nodes are negative nodes and there is no intra-abdominal metastasis the lymphadenectomy is combined with laparoscopically assisted vaginal hysterectomy . If laparoscopy discloses positive lymph nodes , debulking can be carried out and the patient can be referred for radiotherapy . In addition , laparoscopic procedures , even in combination with radical cervicectomy for early invasive carcinoma of the cervix , can mean conservation of the patient's fertility . In the case of primarily inoperable tumours laparoscopy can be used to assess the lymph node status and the intra-abdominal tumour spread and to classify the patient's condition as potentially secondarily operable or inoperable . In addition , in the case of primarily undertreated patients whose carcinoma of the cervix has been diagnosed incidentally in preparations of tissue examined following hysterectomy , posttreatment in the form of laparoscopic lymphadenectomy and laparoscopically assisted colpectomy can be performed ." ], "offsets": [ [ 0, 1445 ] ] } ]	[ { "id": "DerGynaekologe.90320273.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "procedures" ], "offsets": [ [ 13, 23 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0184661" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerGynaekologe.90320273.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "diagnosis" ], "offsets": [ [ 67, 76 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011900" }, { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerGynaekologe.90320273.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 81, 88 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": 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DerGynaekologe.90320280.eng.abstr	DerGynaekologe.90320280.eng.abstr	[ { "id": "DerGynaekologe.90320280.eng.abstr-passage-0", "type": "abstract", "text": [ "The basic forms of therapy that can be applied in the treatment of advanced stages of carcinoma of the cervix are surgery and radiotherapy . While stage 1b ist treated by surgical operation , such as the extended radical operation after Wertheim and systematic lymphadenectomy after Meigs , in the vast majority of cases throughout the world , in the case of larger cervical tumours ( > 4 cm/1b2) and in stage IIb , with extension of the carcinoma into the parametrium , radiotherapy is mostly used . Data on tumour spread from the cervix by way of the parametrium into the pelvic lymph nodes show that prognostic factors allowing for an assessment of the individual patient's chances cannot be elaborated except on the basis of the histopathological investigation of the tissue resected during the radical operation . The 5-year survival rates show that the extended radical abdominal operation combined with radical pelvic lymphadenectomy , when performed in centres where there is special training and especially in the case of advanced tumours of the cervix ( FIGO stages lb2/IIb) and involved pelvic and/or para-aortal lymph nodes in the first ray , can yield results that are comparable to or even better than those of resection ." ], "offsets": [ [ 0, 1236 ] ] } ]	[ { "id": "DerGynaekologe.90320280.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "forms" ], "offsets": [ [ 10, 15 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376315" } ] }, { "id": "DerGynaekologe.90320280.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 19, 26 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerGynaekologe.90320280.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 54, 63 ] ], 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"offsets": [ [ 126, 138 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034618" }, { "db_name": "UMLS", "db_id": "C0034619" } ] }, { "id": "DerGynaekologe.90320280.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "stage" ], "offsets": [ [ 147, 152 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027646" } ] }, { "id": "DerGynaekologe.90320280.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "surgical" ], "offsets": [ [ 171, 179 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "DerGynaekologe.90320280.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "operation" ], "offsets": [ [ 180, 189 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0543467" }, { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "DerGynaekologe.90320280.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "operation" ], "offsets": [ [ 221, 230 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0543467" }, { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": 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It therefore seems desirable to look for therapeutic concepts , with the aim of improving the present results further by means of new combinations of irradiation with a systemic therapy ." ], "offsets": [ [ 0, 737 ] ] } ]	[ { "id": "DerGynaekologe.90320306.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "carcinoma" ], "offsets": [ [ 9, 18 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007097" } ] }, { "id": "DerGynaekologe.90320306.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "screening" ], "offsets": [ [ 19, 28 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220908" }, { "db_name": "UMLS", "db_id": "C0220909" } ] }, { "id": "DerGynaekologe.90320306.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "carcinoma" ], "offsets": [ [ 64, 73 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007097" } ] }, { "id": "DerGynaekologe.90320306.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "tumour" ], "offsets": [ [ 106, 112 ] ], "normalized": [ { "db_name": "UMLS", "db_id": 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DerGynaekologe.90320312.eng.abstr	DerGynaekologe.90320312.eng.abstr	[ { "id": "DerGynaekologe.90320312.eng.abstr-passage-0", "type": "abstract", "text": [ "Approximately one out of every three patients with carcinoma of the cervix must be expected to experience a recurrence . The treatment of such relapses is dependent on the site and extension of the recurrence , the type of primary therapy administered and the patient's general condition . The limit conditions for the application of the established forms of therapy available - surgical operation , radiotherapy , chemotherapy - are complex and seldom documented by randomized studies . In general , empiric observations and historical analyses determine the backdrop against which therapy is planned . The main experiences available are compiled in this paper to give a basis for individual treatment of patients with recurrences ." ], "offsets": [ [ 0, 733 ] ] } ]	[ { "id": "DerGynaekologe.90320312.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 37, 45 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerGynaekologe.90320312.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "carcinoma" ], "offsets": [ [ 51, 60 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007097" } ] }, { "id": "DerGynaekologe.90320312.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "cervix" ], "offsets": [ [ 68, 74 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007874" } ] }, { "id": "DerGynaekologe.90320312.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "recurrence" ], "offsets": [ [ 108, 118 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034897" } ] }, { "id": "DerGynaekologe.90320312.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 125, 134 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerGynaekologe.90320312.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "relapses" ], "offsets": [ [ 143, 151 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035020" } ] }, { "id": "DerGynaekologe.90320312.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "recurrence" ], "offsets": [ [ 198, 208 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034897" } ] }, { "id": "DerGynaekologe.90320312.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 231, 238 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerGynaekologe.90320312.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "forms" ], "offsets": [ [ 350, 355 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376315" } ] }, { "id": "DerGynaekologe.90320312.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 359, 366 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerGynaekologe.90320312.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "surgical" ], "offsets": [ [ 379, 387 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "DerGynaekologe.90320312.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "operation" ], "offsets": [ [ 388, 397 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0543467" }, { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "DerGynaekologe.90320312.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "radiotherapy" ], "offsets": [ [ 400, 412 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034618" }, { "db_name": "UMLS", "db_id": "C0034619" } ] }, { "id": "DerGynaekologe.90320312.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "chemotherapy" ], "offsets": [ [ 415, 427 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013216" }, { "db_name": "UMLS", "db_id": "C0013217" } ] }, { "id": "DerGynaekologe.90320312.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "observations" ], "offsets": [ [ 509, 521 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0302523" } ] }, { "id": "DerGynaekologe.90320312.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "analyses" ], "offsets": [ [ 537, 545 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002778" } ] }, { "id": "DerGynaekologe.90320312.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 583, 590 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerGynaekologe.90320312.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "paper" ], "offsets": [ [ 656, 661 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030351" } ] }, { "id": "DerGynaekologe.90320312.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 693, 702 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerGynaekologe.90320312.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 706, 714 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerGynaekologe.90320312.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "recurrences" ], "offsets": [ [ 720, 731 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034897" } ] } ]	[]	[]	[ { "id": "DerGynaekologe.90320312.eng.abstr-s1-r1-t2.1-t4.1", "type": "result_of", "arg1_id": "DerGynaekologe.90320312.eng.abstr-s5-t2", "arg2_id": "DerGynaekologe.90320312.eng.abstr-s5-t4", "normalized": [] }, { "id": "DerGynaekologe.90320312.eng.abstr-s1-r2-t4.1-t2.1", "type": "result_of", "arg1_id": "DerGynaekologe.90320312.eng.abstr-s5-t4", "arg2_id": "DerGynaekologe.90320312.eng.abstr-s5-t2", "normalized": [] }, { "id": "DerGynaekologe.90320312.eng.abstr-s1-r3-t2.1-t1.1", "type": "occurs_in", "arg1_id": "DerGynaekologe.90320312.eng.abstr-s5-t2", "arg2_id": "DerGynaekologe.90320312.eng.abstr-s5-t1", "normalized": [] }, { "id": "DerGynaekologe.90320312.eng.abstr-s1-r4-t3.1-t2.1", "type": "location_of", "arg1_id": "DerGynaekologe.90320312.eng.abstr-s5-t3", "arg2_id": "DerGynaekologe.90320312.eng.abstr-s5-t2", "normalized": [] }, { "id": "DerGynaekologe.90320312.eng.abstr-s4-r1-t2.1-t3.1", "type": "method_of", "arg1_id": "DerGynaekologe.90320312.eng.abstr-s5-t2", "arg2_id": "DerGynaekologe.90320312.eng.abstr-s5-t3", "normalized": [] }, { "id": "DerGynaekologe.90320312.eng.abstr-s5-r1-t2.1-t1.1", "type": "uses", "arg1_id": "DerGynaekologe.90320312.eng.abstr-s5-t2", "arg2_id": "DerGynaekologe.90320312.eng.abstr-s5-t1", "normalized": [] } ]
DerGynaekologe.90320322.eng.abstr	DerGynaekologe.90320322.eng.abstr	[ { "id": "DerGynaekologe.90320322.eng.abstr-passage-0", "type": "abstract", "text": [ "Up to the middle of the 1970s , chemotherapy had only a marginal role in the overall treatment concept for cervical carcinoma , and surgery and radiotherapy are still the cornerstones of treatment today . There are indications for chemotherapy , which can theoretically be used as follows :" ], "offsets": [ [ 0, 290 ] ] } ]	[ { "id": "DerGynaekologe.90320322.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "chemotherapy" ], "offsets": [ [ 32, 44 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013216" }, { "db_name": "UMLS", "db_id": "C0013217" } ] }, { "id": "DerGynaekologe.90320322.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "role" ], "offsets": [ [ 65, 69 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035820" } ] }, { "id": "DerGynaekologe.90320322.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "overall" ], "offsets": [ [ 77, 84 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0282416" } ] }, { "id": "DerGynaekologe.90320322.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 85, 94 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerGynaekologe.90320322.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "carcinoma" ], "offsets": [ [ 116, 125 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007097" } ] }, { "id": "DerGynaekologe.90320322.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "surgery" ], "offsets": [ [ 132, 139 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038894" }, { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "DerGynaekologe.90320322.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "radiotherapy" ], "offsets": [ [ 144, 156 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034618" }, { "db_name": "UMLS", "db_id": "C0034619" } ] }, { "id": "DerGynaekologe.90320322.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 187, 196 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerGynaekologe.90320322.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "chemotherapy" ], "offsets": [ [ 231, 243 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013216" }, { "db_name": "UMLS", "db_id": "C0013217" } ] } ]	[]	[]	[ { "id": "DerGynaekologe.90320322.eng.abstr-s1-r1-t1.2-t6.1", "type": "associated_with", "arg1_id": "DerGynaekologe.90320322.eng.abstr-s2-t1", "arg2_id": "DerGynaekologe.90320322.eng.abstr-s1-t6", "normalized": [] }, { "id": "DerGynaekologe.90320322.eng.abstr-s1-r2-t3.1-t4.1", "type": "associated_with", "arg1_id": "DerGynaekologe.90320322.eng.abstr-s1-t3", "arg2_id": "DerGynaekologe.90320322.eng.abstr-s1-t4", "normalized": [] }, { "id": "DerGynaekologe.90320322.eng.abstr-s1-r3-t3.1-t1.2", "type": "result_of", "arg1_id": "DerGynaekologe.90320322.eng.abstr-s1-t3", "arg2_id": "DerGynaekologe.90320322.eng.abstr-s2-t1", "normalized": [] }, { "id": "DerGynaekologe.90320322.eng.abstr-s1-r4-t6.1-t1.2", "type": "associated_with", "arg1_id": "DerGynaekologe.90320322.eng.abstr-s1-t6", "arg2_id": "DerGynaekologe.90320322.eng.abstr-s2-t1", "normalized": [] }, { "id": "DerGynaekologe.90320322.eng.abstr-s1-r5-t3.1-t6.1", "type": "issue_in", "arg1_id": "DerGynaekologe.90320322.eng.abstr-s1-t3", "arg2_id": "DerGynaekologe.90320322.eng.abstr-s1-t6", "normalized": [] }, { "id": "DerGynaekologe.90320322.eng.abstr-s1-r6-t3.1-t1.1", "type": "associated_with", "arg1_id": "DerGynaekologe.90320322.eng.abstr-s1-t3", "arg2_id": "DerGynaekologe.90320322.eng.abstr-s2-t1", "normalized": [] }, { "id": "DerGynaekologe.90320322.eng.abstr-s1-r7-t7.2-t6.1", "type": "issue_in", "arg1_id": "DerGynaekologe.90320322.eng.abstr-s1-t7", "arg2_id": "DerGynaekologe.90320322.eng.abstr-s1-t6", "normalized": [] }, { "id": "DerGynaekologe.90320322.eng.abstr-s1-r8-t3.1-t8.1", "type": "associated_with", "arg1_id": "DerGynaekologe.90320322.eng.abstr-s1-t3", "arg2_id": "DerGynaekologe.90320322.eng.abstr-s1-t8", "normalized": [] }, { "id": "DerGynaekologe.90320322.eng.abstr-s1-r9-t3.1-t6.2", "type": "associated_with", "arg1_id": "DerGynaekologe.90320322.eng.abstr-s1-t3", "arg2_id": "DerGynaekologe.90320322.eng.abstr-s1-t6", "normalized": [] } ]
DerGynaekologe.90320354.eng.abstr	DerGynaekologe.90320354.eng.abstr	[ { "id": "DerGynaekologe.90320354.eng.abstr-passage-0", "type": "abstract", "text": [ "An adequate increase of uterine blood flow throughout gestation is essential for uterine , placental and fetal growth . Maternal cardiovascular adaptation has to provide the uterine perfusion that is necessary to meet the requirements of the developing and growing fetus by providing transport of nutrients and oxygen to the placenta and the fetus . Thus uterine blood flow is inextricably linked to fetal growth and survival . Reductions of uterine blood flow can occur under acute or chronic conditions or in a combination of both . Chronic reductions of uterine blood flow can be observed in pregnancy induced hyertension ( PIH ) , diabetes mellitus in pregnancy and intrauterine growth restriction ( IUGR ) . Chronic restrictions in uterine blood flow will elicit a placental and fetal response in the form of growth adaptation to the reduced supply of oxygen and nutrients to the conceptus . If compensatory growth restriction reaches its limits intrauterine fetal distress can ensue ." ], "offsets": [ [ 0, 990 ] ] } ]	[ { "id": "DerGynaekologe.90320354.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "blood" ], "offsets": [ [ 32, 37 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005767" }, { "db_name": "UMLS", "db_id": "C0005768" }, { "db_name": "UMLS", "db_id": "C0005835" } ] }, { "id": "DerGynaekologe.90320354.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "growth" ], "offsets": [ [ 111, 117 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018270" }, { "db_name": "UMLS", "db_id": "C0220844" } ] }, { "id": "DerGynaekologe.90320354.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "adaptation" ], "offsets": [ [ 144, 154 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000934" } ] }, { "id": "DerGynaekologe.90320354.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "perfusion" ], "offsets": [ [ 182, 191 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031001" } ] }, { "id": "DerGynaekologe.90320354.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "fetus" ], "offsets": [ [ 265, 270 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015965" } ] }, { "id": "DerGynaekologe.90320354.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "transport" ], "offsets": [ [ 284, 293 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005528" } ] }, { "id": "DerGynaekologe.90320354.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "oxygen" ], "offsets": [ [ 311, 317 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030054" }, { "db_name": "UMLS", "db_id": "C0184633" } ] }, { "id": "DerGynaekologe.90320354.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "placenta" ], "offsets": [ [ 325, 333 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032043" } ] }, { "id": "DerGynaekologe.90320354.eng.abstr-s2-t7", "type": "umlsterm", "text": [ "fetus" ], "offsets": [ [ 342, 347 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015965" } ] }, { "id": "DerGynaekologe.90320354.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "blood" ], "offsets": [ [ 363, 368 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005767" }, { "db_name": "UMLS", "db_id": "C0005768" }, { "db_name": "UMLS", "db_id": "C0005835" } ] }, { "id": "DerGynaekologe.90320354.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "growth" ], "offsets": [ [ 406, 412 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018270" }, { "db_name": "UMLS", "db_id": "C0220844" } ] }, { "id": "DerGynaekologe.90320354.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "survival" ], "offsets": [ [ 417, 425 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220921" }, { "db_name": "UMLS", "db_id": "C0038952" } ] }, { "id": "DerGynaekologe.90320354.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "blood" ], "offsets": [ [ 450, 455 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005767" }, { "db_name": "UMLS", "db_id": "C0005768" }, { "db_name": "UMLS", "db_id": "C0005835" } ] }, { "id": "DerGynaekologe.90320354.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "blood" ], "offsets": [ [ 565, 570 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005767" }, { "db_name": "UMLS", "db_id": "C0005768" }, { "db_name": "UMLS", "db_id": "C0005835" } ] }, { "id": "DerGynaekologe.90320354.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "pregnancy" ], "offsets": [ [ 595, 604 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "DerGynaekologe.90320354.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "PIH" ], "offsets": [ [ 627, 630 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033373" } ] }, { "id": "DerGynaekologe.90320354.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "diabetes" ], "offsets": [ [ 635, 643 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011847" }, { "db_name": "UMLS", "db_id": "C0011849" } ] }, { "id": "DerGynaekologe.90320354.eng.abstr-s5-t5", "type": "umlsterm", "text": [ "pregnancy" ], "offsets": [ [ 656, 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DerGynaekologe.90320360.eng.abstr	DerGynaekologe.90320360.eng.abstr	[ { "id": "DerGynaekologe.90320360.eng.abstr-passage-0", "type": "abstract", "text": [ "To test the hypothesis that cardiovascular adaptations to human pregnancy begin in the first 4 weeks post ovulation ( PO ) we obtained estimates of resting heart rate ( HR ) , blood pressure ( BP ) , stroke volume ( SV ) , cardiac output ( CO ) , peripheral resistance ( TPR ) , and venous capacity ( VC ) and compliance ( VCom ) weekly under standard conditions beginning on day 3 of the menstrual cycle . The data obtained in cycles with conception were compared to those in which conception did not occur . Techniques utilized included EKG , automated blood pressure measurement ( Dynamap ) , echocardiography , and plethysmography . No directional changes were observed in any parameter during the cycles in which conception did not occur . However , in cycles in which conception occurred HR increased 10 bpm within 1 week PO and remained at that level for the next 7 weeks . BP did not fall significantly until the 5th week PO . SV rose significantly between the 2nd and 3rd week PO and plateaued 10 % above pre ovulatory levels thereafter . As a result , CO rose and TPR fell significantly within 1 week PO and plateaued 1.5 l/min above and 300 dyne/cm/s-5 below pre ovulatory levels by the 3rd PO week . VC increased and followed a similar time course . These changes were associated with rapid increases in human chorionic gonadotropin , a fourfold increase in estradiol , and a twofold increase in progesterone . We conclude that the hypothesis is correct and speculate that the cardiovascular changes are initiated by the rapidly changing hormonal milieu ." ], "offsets": [ [ 0, 1567 ] ] } ]	[ { "id": "DerGynaekologe.90320360.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "adaptations" ], "offsets": [ [ 43, 54 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000934" } ] }, { "id": "DerGynaekologe.90320360.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "human" ], "offsets": [ [ 58, 63 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020114" } ] }, { "id": "DerGynaekologe.90320360.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "pregnancy" ], "offsets": [ [ 64, 73 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "DerGynaekologe.90320360.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "ovulation" ], "offsets": [ [ 106, 115 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029965" } ] }, { "id": "DerGynaekologe.90320360.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "heart" ], "offsets": [ [ 156, 161 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018787" } ] }, { "id": "DerGynaekologe.90320360.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "blood" ], "offsets": [ [ 176, 181 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005767" }, { "db_name": "UMLS", "db_id": "C0005768" }, { "db_name": "UMLS", "db_id": "C0005835" } ] }, { "id": "DerGynaekologe.90320360.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "pressure" ], "offsets": [ [ 182, 190 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033095" } ] }, { "id": "DerGynaekologe.90320360.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "stroke" ], "offsets": [ [ 200, 206 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038454" } ] }, { "id": "DerGynaekologe.90320360.eng.abstr-s1-t9", "type": "umlsterm", "text": [ "compliance" ], "offsets": [ [ 310, 320 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030680" }, { "db_name": "UMLS", "db_id": "C0009563" } ] }, { "id": "DerGynaekologe.90320360.eng.abstr-s1-t10", "type": "umlsterm", "text": [ "standard" ], "offsets": [ [ 343, 351 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038137" }, { "db_name": "UMLS", "db_id": "C0175675" } ] }, { "id": "DerGynaekologe.90320360.eng.abstr-s1-t11", "type": "umlsterm", "text": [ "heart rate" ], "offsets": [ [ 156, 166 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018810" } ] }, { "id": "DerGynaekologe.90320360.eng.abstr-s1-t12", "type": "umlsterm", "text": [ "blood pressure" ], "offsets": [ [ 176, 190 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005823" }, { "db_name": "UMLS", "db_id": "C0005824" } ] }, { "id": "DerGynaekologe.90320360.eng.abstr-s1-t13", "type": "umlsterm", "text": [ "stroke volume" ], "offsets": [ [ 200, 213 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038455" } ] }, { "id": "DerGynaekologe.90320360.eng.abstr-s1-t14", "type": "umlsterm", "text": [ "cardiac output" ], "offsets": [ [ 223, 237 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007165" } ] }, { "id": "DerGynaekologe.90320360.eng.abstr-s1-t15", "type": "umlsterm", "text": [ "peripheral resistance" ], "offsets": [ [ 247, 268 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042380" } ] }, { "id": "DerGynaekologe.90320360.eng.abstr-s1-t16", "type": "umlsterm", "text": [ "menstrual cycle" ], "offsets": [ [ 389, 404 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025329" } ] }, { "id": "DerGynaekologe.90320360.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "conception" ], "offsets": [ [ 440, 450 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009637" } ] }, { "id": "DerGynaekologe.90320360.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "conception" ], "offsets": [ [ 483, 493 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009637" } ] }, { "id": "DerGynaekologe.90320360.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "Techniques" ], "offsets": [ [ 510, 520 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerGynaekologe.90320360.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "EKG" ], "offsets": [ [ 539, 542 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013798" } ] }, { "id": "DerGynaekologe.90320360.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "blood" ], "offsets": [ [ 555, 560 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005767" }, { "db_name": "UMLS", "db_id": "C0005768" }, { "db_name": "UMLS", "db_id": "C0005835" } ] }, { "id": "DerGynaekologe.90320360.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "pressure" ], "offsets": [ [ 561, 569 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033095" } ] }, { "id": "DerGynaekologe.90320360.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "measurement" ], "offsets": [ [ 570, 581 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242485" } ] }, { "id": "DerGynaekologe.90320360.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "plethysmography" ], "offsets": [ [ 619, 634 ] ], "normalized": [ 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This increase in stroke volume in the course of pregnancy and its normalization after delivery can be measured by means of Doppler ultrasound either as systolic peak velocity or as time-velocity integral ." ], "offsets": [ [ 0, 396 ] ] } ]	[ { "id": "DerGynaekologe.90320367.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "pregnancy" ], "offsets": [ [ 38, 47 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "DerGynaekologe.90320367.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "blood" ], "offsets": [ [ 102, 107 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005767" }, { "db_name": "UMLS", "db_id": "C0005768" }, { "db_name": "UMLS", "db_id": "C0005835" } ] }, { "id": "DerGynaekologe.90320367.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "vessel" ], "offsets": [ [ 171, 177 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005847" }, { "db_name": "UMLS", "db_id": "C0148346" } ] }, { "id": "DerGynaekologe.90320367.eng.abstr-s1-t4", "type": 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DerGynaekologe.90320386.eng.abstr	DerGynaekologe.90320386.eng.abstr	[ { "id": "DerGynaekologe.90320386.eng.abstr-passage-0", "type": "abstract", "text": [ "In daily obstetrical practice there is an increasing need on information about questions regarding lifestyle during pregnancy . The concern , discussion and knowledge however , exist since early times of medical history ( e . g . Hippocrates 480 BC ) . The subject \" floats \" between physiological changes caused by gestational alterations and needs on the one hand and - on the other hand - the effects of physical activities ." ], "offsets": [ [ 0, 428 ] ] } ]	[ { "id": "DerGynaekologe.90320386.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "need" ], "offsets": [ [ 53, 57 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027552" } ] }, { "id": "DerGynaekologe.90320386.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "lifestyle" ], "offsets": [ [ 99, 108 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023676" } ] }, { "id": "DerGynaekologe.90320386.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "pregnancy" ], "offsets": [ [ 116, 125 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "DerGynaekologe.90320386.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "knowledge" ], "offsets": [ [ 157, 166 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376554" } ] }, { "id": "DerGynaekologe.90320386.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "times" ], "offsets": [ [ 195, 200 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040223" } ] }, { "id": "DerGynaekologe.90320386.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "history" ], "offsets": [ [ 212, 219 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019664" }, { "db_name": "UMLS", "db_id": "C0019665" } ] }, { "id": "DerGynaekologe.90320386.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "hand" ], "offsets": [ [ 361, 365 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018563" } ] }, { "id": "DerGynaekologe.90320386.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "hand" ], "offsets": [ [ 385, 389 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018563" } ] } ]	[]	[]	[ { "id": "DerGynaekologe.90320386.eng.abstr-s2-r1-t1.1-t3.1", "type": "issue_in", "arg1_id": "DerGynaekologe.90320386.eng.abstr-s5-t1", "arg2_id": "DerGynaekologe.90320386.eng.abstr-s2-t3", "normalized": [] }, { "id": "DerGynaekologe.90320386.eng.abstr-s2-r3-t2.1-t3.1", "type": "issue_in", "arg1_id": "DerGynaekologe.90320386.eng.abstr-s5-t2", "arg2_id": "DerGynaekologe.90320386.eng.abstr-s2-t3", "normalized": [] } ]
DerGynaekologe.90320426.eng.abstr	DerGynaekologe.90320426.eng.abstr	[ { "id": "DerGynaekologe.90320426.eng.abstr-passage-0", "type": "abstract", "text": [ "The mean arterial blood pressure is decreased during the first two trimesters of pregnancy and increases to preconceptional values during the last weeks of gestation . The heart rate increases during the whole course of pregnancy . During late gestation fewer patients show an increase in diastolic blood pressure and heart rate in the standing position . A fall in heart rate was only seen in this period . A fall in mean arterial blood pressure during standing is not related to the blood pressure in the supine position during the whole course of pregnancy . The hypotensive symptoms are twice as frequent during early pregnancy compared to late pregnancy . Headaches , fatigue and cold extremities are the most usual complaints . The frequency and intensity of these three symptoms decrease during gestation . Blood pressure in the supine position is reduced in symptomatic pregnant women . However , the occurrence of these symptoms is not correlated to the fall in blood pressure in the standing position . The Birth-weight is not influenced by blood pressure in the supine position , but depends on the fall in blood pressure during standing . Pregnant women with a more pronounced fall in blood pressure give birth to newborns with a lower birthweight . These results imply a hitherto unknown cause of intrauterine growth restriction ." ], "offsets": [ [ 0, 1343 ] ] } ]	[ { "id": "DerGynaekologe.90320426.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "blood" ], "offsets": [ [ 18, 23 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005767" }, { "db_name": "UMLS", "db_id": "C0005768" }, { "db_name": "UMLS", "db_id": "C0005835" } ] }, { "id": "DerGynaekologe.90320426.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "pressure" ], "offsets": [ [ 24, 32 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033095" } ] }, { "id": "DerGynaekologe.90320426.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "pregnancy" ], "offsets": [ [ 81, 90 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "DerGynaekologe.90320426.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "values" ], "offsets": [ [ 124, 130 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042295" } ] }, { "id": "DerGynaekologe.90320426.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "blood pressure" ], "offsets": [ [ 18, 32 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005823" }, { "db_name": "UMLS", "db_id": "C0005824" } ] }, { "id": "DerGynaekologe.90320426.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "heart" ], "offsets": [ [ 172, 177 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018787" } ] }, { "id": "DerGynaekologe.90320426.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "pregnancy" ], "offsets": [ [ 220, 229 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "DerGynaekologe.90320426.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "heart rate" ], "offsets": [ [ 172, 182 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018810" } ] }, { "id": "DerGynaekologe.90320426.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 260, 268 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerGynaekologe.90320426.eng.abstr-s3-t2", "type": 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}, { "id": "DerGynaekologe.90320426.eng.abstr-s12-t1", "type": "umlsterm", "text": [ "women" ], "offsets": [ [ 1160, 1165 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043210" } ] }, { "id": "DerGynaekologe.90320426.eng.abstr-s12-t2", "type": "umlsterm", "text": [ "blood" ], "offsets": [ [ 1197, 1202 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005767" }, { "db_name": "UMLS", "db_id": "C0005768" }, { "db_name": "UMLS", "db_id": "C0005835" } ] }, { "id": "DerGynaekologe.90320426.eng.abstr-s12-t3", "type": "umlsterm", "text": [ "pressure" ], "offsets": [ [ 1203, 1211 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033095" } ] }, { "id": "DerGynaekologe.90320426.eng.abstr-s12-t4", "type": "umlsterm", "text": [ "birth" ], "offsets": [ [ 1217, 1222 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005615" } ] }, { "id": "DerGynaekologe.90320426.eng.abstr-s12-t5", "type": "umlsterm", "text": [ "newborns" ], "offsets": [ [ 1226, 1234 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021289" } ] }, { "id": "DerGynaekologe.90320426.eng.abstr-s12-t6", "type": "umlsterm", "text": [ "birthweight" ], "offsets": [ [ 1248, 1259 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005612" } ] }, { "id": "DerGynaekologe.90320426.eng.abstr-s12-t7", "type": "umlsterm", "text": [ "Pregnant women" ], "offsets": [ [ 1151, 1165 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033011" } ] }, { "id": "DerGynaekologe.90320426.eng.abstr-s12-t8", "type": "umlsterm", "text": [ "in blood" ], "offsets": [ [ 1194, 1202 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005768" } ] }, { "id": "DerGynaekologe.90320426.eng.abstr-s12-t9", "type": "umlsterm", "text": [ "blood pressure" ], "offsets": [ [ 1197, 1211 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005823" }, { "db_name": "UMLS", "db_id": "C0005824" } ] }, { "id": "DerGynaekologe.90320426.eng.abstr-s12-t10", "type": "umlsterm", "text": [ "lower birthweight" ], "offsets": [ [ 1242, 1259 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DerGynaekologe.90320432.eng.abstr	DerGynaekologe.90320432.eng.abstr	[ { "id": "DerGynaekologe.90320432.eng.abstr-passage-0", "type": "abstract", "text": [ "Hypertensive diseases in pregnancy ( HDP ) are one of the most frequent causes of maternal death and perinatal mortality . However , chronic hypertension without complications has a more favorable prognosis than preeclampsia . Apart from a familial predisposition , mutations of various genes may also be responsible ; among these , APC resistance is of particular clinical significance . The insufficient endovascular invasion of trophoblast in the spiral aterioles is still considered to represent the pathogenetic basis of preeclampsia . Increased lipid oxidation , deported membrane components of syncytiotrophoblasts , and increased invasion of fetal cells in the maternal circulation triggering immunological reactions are discussed as the causes . The result is an endothelial imbalance between vasoconstrictory-aggregating and vasodilatatory-antiaggregating compounds . The results of studies on the relevance of NO synthase are controversial . Currently , neither reliable methods for the early detection nor certain preventative measures to avoid the disease are available . Intensive care monitoring and therapy are essential for pregnant women with severe HDP . The obstetric procedure depends on the severity and dynamics of the disease as well as the state of development of the baby . When the pregnancy is continued defined guidelines for its termination for maternal or fetal indications must be taken into consideration . After delivery , the mother must be intensively monitored for at least 24 to 48 hours ( postpartal eclampsia/HELLP syndrome ) . The risk for recurrence of the preeclampsia is between 20 and 26 % or when it occurred in the second trimester up to 65 % while that of HELLP syndrome is between 3.5 and 24 % ." ], "offsets": [ [ 0, 1744 ] ] } ]	[ { "id": "DerGynaekologe.90320432.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "diseases" ], "offsets": [ [ 13, 21 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerGynaekologe.90320432.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "pregnancy" ], "offsets": [ [ 25, 34 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "DerGynaekologe.90320432.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "causes" ], "offsets": [ [ 72, 78 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015127" } ] }, { "id": "DerGynaekologe.90320432.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "death" ], "offsets": [ [ 91, 96 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011065" } ] }, { "id": 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] }, { "id": "DerGynaekologe.90320432.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "complications" ], "offsets": [ [ 162, 175 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009566" } ] }, { "id": "DerGynaekologe.90320432.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "prognosis" ], "offsets": [ [ 197, 206 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033325" } ] }, { "id": "DerGynaekologe.90320432.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "preeclampsia" ], "offsets": [ [ 212, 224 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032914" } ] }, { "id": "DerGynaekologe.90320432.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "predisposition" ], "offsets": [ [ 249, 263 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012655" } ] }, { "id": "DerGynaekologe.90320432.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "mutations" ], "offsets": [ [ 266, 275 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026882" } ] }, { "id": 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DerGynaekologe.90320450.eng.abstr	DerGynaekologe.90320450.eng.abstr	[ { "id": "DerGynaekologe.90320450.eng.abstr-passage-0", "type": "abstract", "text": [ "Cardiac transplantation ( HTX ) is accepted as an effective treatment for some end-stage cardiac diseases . Maternal risks during pregnancies after HTX include : hypertension , allograft rejection , infections and renal insufficiency . Potential risks to the fetus include side effects of immunosuppressives , preterm delivery and growth restriction . Pregnancies in cardiac transplant recipients should be considered high risk . This review demonstrates the variety of problems concerning pregnancy and delivery after HTX to help the doctor to advise these patients ." ], "offsets": [ [ 0, 568 ] ] } ]	[ { "id": "DerGynaekologe.90320450.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "transplantation" ], "offsets": [ [ 8, 23 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029216" }, { "db_name": "UMLS", "db_id": "C0040732" }, { "db_name": "UMLS", "db_id": "C0040733" } ] }, { "id": "DerGynaekologe.90320450.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 60, 69 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerGynaekologe.90320450.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "diseases" ], "offsets": [ [ 97, 105 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerGynaekologe.90320450.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "Cardiac transplantation" ], "offsets": [ [ 0, 23 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018823" } ] }, { "id": "DerGynaekologe.90320450.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "cardiac diseases" ], "offsets": [ [ 89, 105 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018799" } ] }, { "id": "DerGynaekologe.90320450.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "risks" ], "offsets": [ [ 117, 122 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "DerGynaekologe.90320450.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "pregnancies" ], "offsets": [ [ 130, 141 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "DerGynaekologe.90320450.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "hypertension" ], "offsets": [ [ 162, 174 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020538" } ] }, { "id": "DerGynaekologe.90320450.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "rejection" ], "offsets": [ [ 187, 196 ] ], "normalized": [ { "db_name": "UMLS", 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DerGynaekologe.90320455.eng.abstr	DerGynaekologe.90320455.eng.abstr	[ { "id": "DerGynaekologe.90320455.eng.abstr-passage-0", "type": "abstract", "text": [ "Question : What risks do different forms of immunosuppression ( azathioprine , Cyclosporin , azathioprine/Cyclosporin plus steroids ) represent in pregnancy for the mother and fetus after kidney transplantation ? Retrospective analysis of 40 pregnancies and deliveries . Investigation of abortion - , premature birth rate , fetal retardation , malformation , hospitalization , modus of labour , birth weight , gestational age , perinatal mortality , hypertonia , preeclampsia , anemia , kidney function , rejection crisis , mechanical compression , kidney function after 1 and 5 years postpartum . Recommendation guideline : preconceptional time ( contraception ) and intensive care in pregnancy . The risk of pregnancy is justified if the presuppositions are correct and the woman would urgently like to have a child ." ], "offsets": [ [ 0, 819 ] ] } ]	[ { "id": "DerGynaekologe.90320455.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "risks" ], "offsets": [ [ 16, 21 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "DerGynaekologe.90320455.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "forms" ], "offsets": [ [ 35, 40 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376315" } ] }, { "id": "DerGynaekologe.90320455.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "immunosuppression" ], "offsets": [ [ 44, 61 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021080" }, { "db_name": "UMLS", "db_id": "C0021079" } ] }, { "id": "DerGynaekologe.90320455.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "azathioprine" ], "offsets": [ [ 64, 76 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004482" } ] }, { "id": "DerGynaekologe.90320455.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "Cyclosporin" ], "offsets": [ [ 79, 90 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010592" }, { "db_name": "UMLS", "db_id": "C0010594" } ] }, { "id": "DerGynaekologe.90320455.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "steroids" ], "offsets": [ [ 123, 131 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038317" } ] }, { "id": "DerGynaekologe.90320455.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "pregnancy" ], "offsets": [ [ 147, 156 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "DerGynaekologe.90320455.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "mother" ], "offsets": [ [ 165, 171 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026591" } ] }, { "id": "DerGynaekologe.90320455.eng.abstr-s1-t9", "type": "umlsterm", "text": [ "fetus" ], "offsets": [ [ 176, 181 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015965" } ] }, { "id": "DerGynaekologe.90320455.eng.abstr-s1-t10", "type": "umlsterm", "text": [ "kidney" ], "offsets": [ [ 188, 194 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022646" } ] }, { "id": "DerGynaekologe.90320455.eng.abstr-s1-t11", "type": "umlsterm", "text": [ "transplantation" ], "offsets": [ [ 195, 210 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029216" }, { "db_name": "UMLS", "db_id": "C0040732" }, { "db_name": "UMLS", "db_id": "C0040733" } ] }, { "id": "DerGynaekologe.90320455.eng.abstr-s1-t12", "type": "umlsterm", "text": [ "kidney transplantation" ], "offsets": [ [ 188, 210 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022671" } ] }, { "id": "DerGynaekologe.90320455.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "Retrospective" ], "offsets": [ [ 213, 226 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035363" } ] }, { "id": "DerGynaekologe.90320455.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "analysis" ], "offsets": [ [ 227, 235 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002778" } ] }, { "id": "DerGynaekologe.90320455.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "pregnancies" ], "offsets": [ [ 242, 253 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "DerGynaekologe.90320455.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "deliveries" ], "offsets": [ [ 258, 268 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011209" } ] }, { "id": "DerGynaekologe.90320455.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "abortion" ], "offsets": [ [ 288, 296 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000786" }, { "db_name": "UMLS", "db_id": "C0000811" } ] }, { "id": "DerGynaekologe.90320455.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "birth" ], "offsets": [ [ 311, 316 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005615" } ] }, { "id": "DerGynaekologe.90320455.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "malformation" ], "offsets": [ [ 344, 356 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000768" }, { "db_name": "UMLS", "db_id": "C0243070" } ] }, { "id": "DerGynaekologe.90320455.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "hospitalization" ], "offsets": [ [ 359, 374 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019993" } ] }, { "id": "DerGynaekologe.90320455.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "labour" ], "offsets": [ [ 386, 392 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022864" } ] }, { "id": "DerGynaekologe.90320455.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "birth" ], "offsets": [ [ 395, 400 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005615" } ] }, { "id": "DerGynaekologe.90320455.eng.abstr-s3-t7", "type": "umlsterm", "text": [ "weight" ], "offsets": [ [ 401, 407 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005910" }, { "db_name": "UMLS", "db_id": "C0043100" } ] }, { "id": "DerGynaekologe.90320455.eng.abstr-s3-t8", "type": "umlsterm", "text": [ "age" ], "offsets": [ [ 422, 425 ] ], 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DerGynaekologe.90320496.eng.abstr	DerGynaekologe.90320496.eng.abstr	[ { "id": "DerGynaekologe.90320496.eng.abstr-passage-0", "type": "abstract", "text": [ "Even if Ignaz Philipp Semmelweis has not found the true aetiology of puerperal fever - bacteria were identified as pathogens only after his observations - he was the first to consequently use epidemiological methods in order to elucidate connections and influencing factors in the spread of nosocomial infections , to draw the right conclusions from his observations on the transmission of childbed fever and to draw the right consequences by implementing preventive measures , especially the hand disinfection . He has correctly realized that human beings suffering from purulent or putride lesions or having even died from them can act as infectious sources as can hands of health-care personnel act as vehicles . As a characteristic feature of nosocomial infection , he noticed that generally only the weakend organism of the patient is involved as an infection target . The impact of his doctrine not only made him \" saviour of the mothers \" but also justifies to regard him as \" father of the obstetric infection prevention \" if not even as the founder of the modern science-based hospital hygiene ." ], "offsets": [ [ 0, 1104 ] ] } ]	[ { "id": "DerGynaekologe.90320496.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "aetiology" ], "offsets": [ [ 56, 65 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007463" } ] }, { "id": "DerGynaekologe.90320496.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "puerperal" ], "offsets": [ [ 69, 78 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086839" } ] }, { "id": "DerGynaekologe.90320496.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "fever" ], "offsets": [ [ 79, 84 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015967" } ] }, { "id": "DerGynaekologe.90320496.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "bacteria" ], "offsets": [ [ 87, 95 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004611" }, { "db_name": "UMLS", "db_id": "C0521009" } ] }, { "id": "DerGynaekologe.90320496.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "observations" ], "offsets": [ [ 140, 152 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0302523" } ] }, { "id": "DerGynaekologe.90320496.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "methods" ], "offsets": [ [ 208, 215 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerGynaekologe.90320496.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "infections" ], "offsets": [ [ 302, 312 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021311" } ] }, { "id": "DerGynaekologe.90320496.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "right" ], "offsets": [ [ 327, 332 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035621" } ] }, { "id": "DerGynaekologe.90320496.eng.abstr-s1-t9", "type": "umlsterm", "text": [ "observations" ], "offsets": [ [ 354, 366 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0302523" } ] }, { "id": "DerGynaekologe.90320496.eng.abstr-s1-t10", "type": "umlsterm", "text": [ "transmission" ], "offsets": [ [ 374, 386 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040722" } ] }, { "id": "DerGynaekologe.90320496.eng.abstr-s1-t11", "type": "umlsterm", "text": [ "fever" ], "offsets": [ [ 399, 404 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015967" } ] }, { "id": "DerGynaekologe.90320496.eng.abstr-s1-t12", "type": "umlsterm", "text": [ "right" ], "offsets": [ [ 421, 426 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035621" } ] }, { "id": "DerGynaekologe.90320496.eng.abstr-s1-t13", "type": "umlsterm", "text": [ "preventive" ], "offsets": [ [ 456, 466 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033110" } ] }, { "id": "DerGynaekologe.90320496.eng.abstr-s1-t14", "type": "umlsterm", "text": [ "measures" ], "offsets": [ [ 467, 475 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0079809" } ] }, { "id": "DerGynaekologe.90320496.eng.abstr-s1-t15", "type": "umlsterm", "text": [ "hand" ], "offsets": [ [ 493, 497 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018563" } ] }, { "id": "DerGynaekologe.90320496.eng.abstr-s1-t16", "type": "umlsterm", "text": [ "disinfection" ], "offsets": [ [ 498, 510 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012683" } ] }, { "id": "DerGynaekologe.90320496.eng.abstr-s1-t17", "type": "umlsterm", "text": [ "epidemiological methods" ], "offsets": [ [ 192, 215 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014503" } ] }, { "id": "DerGynaekologe.90320496.eng.abstr-s1-t18", "type": "umlsterm", "text": [ "nosocomial infections" ], "offsets": [ [ 291, 312 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0205721" } ] }, { "id": "DerGynaekologe.90320496.eng.abstr-s1-t19", "type": "umlsterm", "text": [ "preventive measures" ], "offsets": [ [ 456, 475 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033107" } ] }, { "id": "DerGynaekologe.90320496.eng.abstr-s1-t20", "type": "umlsterm", "text": [ "hand disinfection" ], "offsets": [ [ 493, 510 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018570" } ] }, { "id": "DerGynaekologe.90320496.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "human" ], "offsets": [ [ 544, 549 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020114" } ] }, { "id": "DerGynaekologe.90320496.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "hands" ], "offsets": [ [ 667, 672 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018563" } ] }, { "id": "DerGynaekologe.90320496.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "personnel" ], "offsets": [ [ 688, 697 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024752" }, { "db_name": "UMLS", "db_id": "C0700103" } ] }, { "id": "DerGynaekologe.90320496.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "vehicles" ], "offsets": [ [ 705, 713 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042444" } ] }, { "id": "DerGynaekologe.90320496.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "infection" ], "offsets": [ [ 758, 767 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021311" } ] }, { "id": "DerGynaekologe.90320496.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "organism" ], "offsets": [ [ 813, 821 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029235" } ] }, { "id": "DerGynaekologe.90320496.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 829, 836 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerGynaekologe.90320496.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "infection" ], "offsets": [ [ 855, 864 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021311" } ] }, { "id": "DerGynaekologe.90320496.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "nosocomial infection" ], "offsets": [ [ 747, 767 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0205721" } ] }, { "id": "DerGynaekologe.90320496.eng.abstr-s4-t1", 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DerGynaekologe.90320501.eng.abstr	DerGynaekologe.90320501.eng.abstr	[ { "id": "DerGynaekologe.90320501.eng.abstr-passage-0", "type": "abstract", "text": [ "Septic abortion remains one of the most serious threats to the health and life of women throughout the world . Morbidity and mortality are infrequent in countries where induced abortion is legal and medically well organized , but widespread in many developing countries where it is either illegal or inaccessible ." ], "offsets": [ [ 0, 314 ] ] } ]	[ { "id": "DerGynaekologe.90320501.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "abortion" ], "offsets": [ [ 7, 15 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000786" }, { "db_name": "UMLS", "db_id": "C0000811" } ] }, { "id": "DerGynaekologe.90320501.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "health" ], "offsets": [ [ 63, 69 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018684" } ] }, { "id": "DerGynaekologe.90320501.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "life" ], "offsets": [ [ 74, 78 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376558" } ] }, { "id": "DerGynaekologe.90320501.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "women" ], "offsets": [ [ 82, 87 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043210" } ] }, { "id": "DerGynaekologe.90320501.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "Septic abortion" ], "offsets": [ [ 0, 15 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000817" } ] }, { "id": "DerGynaekologe.90320501.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "Morbidity" ], "offsets": [ [ 111, 120 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220880" }, { "db_name": "UMLS", "db_id": "C0026538" } ] }, { "id": "DerGynaekologe.90320501.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "mortality" ], "offsets": [ [ 125, 134 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026566" }, { "db_name": "UMLS", "db_id": "C0026565" } ] }, { "id": "DerGynaekologe.90320501.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "abortion" ], "offsets": [ [ 177, 185 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000786" }, { "db_name": "UMLS", "db_id": "C0000811" } ] }, { "id": "DerGynaekologe.90320501.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "induced abortion" ], "offsets": [ [ 169, 185 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000811" } ] }, { "id": "DerGynaekologe.90320501.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "developing countries" ], "offsets": [ [ 249, 269 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011750" } ] } ]	[]	[]	[ { "id": "DerGynaekologe.90320501.eng.abstr-s1-r1-t1.2-t5.1", "type": "associated_with", "arg1_id": "DerGynaekologe.90320501.eng.abstr-s2-t1", "arg2_id": "DerGynaekologe.90320501.eng.abstr-s2-t5", "normalized": [] }, { "id": "DerGynaekologe.90320501.eng.abstr-s1-r2-t4.1-t1.1", "type": "associated_with", "arg1_id": "DerGynaekologe.90320501.eng.abstr-s2-t4", "arg2_id": "DerGynaekologe.90320501.eng.abstr-s2-t1", "normalized": [] }, { "id": "DerGynaekologe.90320501.eng.abstr-s1-r3-t5.1-t4.1", "type": "associated_with", "arg1_id": "DerGynaekologe.90320501.eng.abstr-s2-t5", "arg2_id": "DerGynaekologe.90320501.eng.abstr-s2-t4", "normalized": [] }, { "id": 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DerGynaekologe.90320507.eng.abstr	DerGynaekologe.90320507.eng.abstr	[ { "id": "DerGynaekologe.90320507.eng.abstr-passage-0", "type": "abstract", "text": [ "Chorioamnionitis has to be considered a uterine infection while the fetus remains inside . Ascending aerobe and anaerobe bacteria are mainly responsible for chorioamnionitis . Amniotic inflammation occurs in 2-4 % of all pregnancies . Women with preterm deliveries and premature rupture of the membrane have an increased risk for developing chorioamnionitis . The published infection rate of the uterus cavity ranges from 10 to 50 % . In 5-10 % of threatened preterm births the intrauterine infection is detectable . Currently , simple test systems are available for analyses of gram-positive bacteria , leukocyte number , cytokines and concentration of glucose in the amniotic fluid completed by cultures for bacteria . The signs and symptoms of chorioamnionitis include elevated maternal temperature ( oral 37.5 °C; rectal 38.0 °C), fetal or maternal tachycardia , and uterine contractions or tenderness . The C-reactive protein ( CRP ) is still the best serum parameter to predict amniotic infection . The two major problems of amniotic inflammation are septic shock for the mother and involvement of the placenta and fetus . To prevent these complications high-dose antibiotics are necessary and immediate delivery should be considered . The local and systemic spread is due to delayed diagnosis and may present as myometritis , endomyometritis , peritonitis , bacteremia , septic pneumonia or shock lung . Additionally , an infection of group B streptococci increases the risk for development of maternal meningitis ." ], "offsets": [ [ 0, 1522 ] ] } ]	[ { "id": "DerGynaekologe.90320507.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Chorioamnionitis" ], "offsets": [ [ 0, 16 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008495" } ] }, { "id": "DerGynaekologe.90320507.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "infection" ], "offsets": [ [ 48, 57 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021311" } ] }, { "id": "DerGynaekologe.90320507.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "fetus" ], "offsets": [ [ 68, 73 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015965" } ] }, { "id": "DerGynaekologe.90320507.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "anaerobe" ], "offsets": [ [ 112, 120 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004613" } ] }, { "id": "DerGynaekologe.90320507.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "bacteria" ], "offsets": [ [ 121, 129 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004611" }, { "db_name": "UMLS", "db_id": "C0521009" } ] }, { "id": "DerGynaekologe.90320507.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "chorioamnionitis" ], "offsets": [ [ 157, 173 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008495" } ] }, { "id": "DerGynaekologe.90320507.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "inflammation" ], "offsets": [ [ 185, 197 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021368" } ] }, { "id": "DerGynaekologe.90320507.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "pregnancies" ], "offsets": [ [ 221, 232 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "DerGynaekologe.90320507.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "Women" ], "offsets": [ [ 235, 240 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043210" } ] }, { "id": "DerGynaekologe.90320507.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "deliveries" ], "offsets": [ [ 254, 264 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011209" } ] }, { "id": "DerGynaekologe.90320507.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "rupture" ], "offsets": [ [ 279, 286 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035955" } ] }, { "id": "DerGynaekologe.90320507.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "membrane" ], "offsets": [ [ 294, 302 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025255" } ] }, { "id": "DerGynaekologe.90320507.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "risk" ], "offsets": [ [ 321, 325 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "DerGynaekologe.90320507.eng.abstr-s4-t6", "type": "umlsterm", "text": [ "chorioamnionitis" ], "offsets": [ [ 341, 357 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008495" } ] }, { "id": "DerGynaekologe.90320507.eng.abstr-s4-t7", "type": "umlsterm", "text": [ "preterm deliveries" ], "offsets": [ [ 246, 264 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0151526" } ] }, { "id": "DerGynaekologe.90320507.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "infection" ], "offsets": [ [ 374, 383 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021311" } ] }, { "id": "DerGynaekologe.90320507.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "uterus" ], "offsets": [ [ 396, 402 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042131" }, { "db_name": "UMLS", "db_id": "C0042149" } ] }, { "id": "DerGynaekologe.90320507.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "births" ], "offsets": [ [ 467, 473 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005615" } ] }, { "id": "DerGynaekologe.90320507.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "infection" ], "offsets": [ [ 491, 500 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021311" } ] }, { "id": "DerGynaekologe.90320507.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "preterm births" ], "offsets": [ [ 459, 473 ] ], "normalized": [ { "db_name": 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"arg1_id": "DerGynaekologe.90320507.eng.abstr-s13-t5", "arg2_id": "DerGynaekologe.90320507.eng.abstr-s13-t6", "normalized": [] } ]
DerGynaekologe.90320518.eng.abstr	DerGynaekologe.90320518.eng.abstr	[ { "id": "DerGynaekologe.90320518.eng.abstr-passage-0", "type": "abstract", "text": [ "Sepsis developing on the basis of a postoperative infection is a rare , but life-threatening event . Early diagnosis of postoperative complications usually facilitates decisive intervention and a favorable prognosis . If the right moment is missed , endothelial damage leads to the release of inflammatory mediators and generalized systemic infection ( SIRS ) . For the subsequentially developing septic shock , often combined with multiple organ failure ( MOF ) , it is not important whether the starting point was an uncontrollable infections focus , ischemic damage following hypovolemic shock , or massive bacterial translocation with postoperative bowel obstruction . The collapse of the immune system results in immune paralysis and explains the inability of the organism to defend itself against systemic infections . For early recognition of the developing septic complication and its effective treatment , pathophysiological and clinical issues are discussed ." ], "offsets": [ [ 0, 969 ] ] } ]	[ { "id": "DerGynaekologe.90320518.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Sepsis" ], "offsets": [ [ 0, 6 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243026" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "postoperative" ], "offsets": [ [ 36, 49 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032790" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "infection" ], "offsets": [ [ 50, 59 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021311" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "diagnosis" ], "offsets": [ [ 107, 116 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011900" }, { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "postoperative" ], "offsets": [ [ 120, 133 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032790" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "complications" ], "offsets": [ [ 134, 147 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009566" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "prognosis" ], "offsets": [ [ 206, 215 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033325" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "postoperative complications" ], "offsets": [ [ 120, 147 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032787" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "right" ], "offsets": [ [ 225, 230 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035621" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "release" ], "offsets": [ [ 282, 289 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0541720" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "mediators" ], "offsets": [ [ 306, 315 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0127400" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "infection" ], "offsets": [ [ 341, 350 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021311" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "SIRS" ], "offsets": [ [ 353, 357 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0142364" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "systemic infection" ], "offsets": [ [ 332, 350 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243026" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "shock" ], "offsets": [ [ 404, 409 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036974" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "infections" ], "offsets": [ [ 534, 544 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021311" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "ischemic" ], "offsets": [ [ 553, 561 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022116" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "shock" ], "offsets": [ [ 591, 596 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036974" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "bacterial" ], "offsets": [ [ 610, 619 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0521009" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s4-t6", "type": "umlsterm", "text": [ "translocation" ], "offsets": [ [ 620, 633 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0599893" }, { "db_name": "UMLS", "db_id": "C0040715" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s4-t7", "type": "umlsterm", "text": [ "postoperative" ], "offsets": [ [ 639, 652 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032790" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s4-t8", "type": "umlsterm", "text": [ "bowel" ], "offsets": [ [ 653, 658 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021853" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s4-t9", "type": "umlsterm", "text": [ "septic shock" ], "offsets": [ [ 397, 409 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036983" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s4-t10", "type": "umlsterm", "text": [ "hypovolemic shock" ], "offsets": [ [ 579, 596 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020683" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s4-t11", "type": "umlsterm", "text": [ "bacterial translocation" ], "offsets": [ [ 610, 633 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0282583" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s4-t12", "type": "umlsterm", "text": [ "bowel obstruction" ], "offsets": [ [ 653, 670 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021843" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s4-t13", "type": "umlsterm", "text": [ "multiple organ failure" ], "offsets": [ [ 432, 454 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026766" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "paralysis" ], "offsets": [ [ 725, 734 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030440" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "organism" ], "offsets": [ [ 769, 777 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029235" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "infections" ], "offsets": [ [ 812, 822 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021311" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "immune system" ], "offsets": [ [ 693, 706 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020962" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s5-t5", "type": "umlsterm", "text": [ "systemic infections" ], "offsets": [ [ 803, 822 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243026" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "recognition" ], "offsets": [ [ 835, 846 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0524637" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "complication" ], "offsets": [ [ 872, 884 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009566" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 903, 912 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] } ]	[]	[]	[ { "id": "DerGynaekologe.90320518.eng.abstr-s2-r1-t1.1-t3.1", "type": "isa", "arg1_id": "DerGynaekologe.90320518.eng.abstr-s6-t1", "arg2_id": "DerGynaekologe.90320518.eng.abstr-s6-t3", "normalized": [] }, { "id": "DerGynaekologe.90320518.eng.abstr-s2-r2-t1.1-t5.1", "type": "associated_with", "arg1_id": "DerGynaekologe.90320518.eng.abstr-s6-t1", "arg2_id": "DerGynaekologe.90320518.eng.abstr-s5-t5", "normalized": [] }, { "id": "DerGynaekologe.90320518.eng.abstr-s2-r3-t5.1-t3.1", "type": "associated_with", "arg1_id": "DerGynaekologe.90320518.eng.abstr-s5-t5", "arg2_id": "DerGynaekologe.90320518.eng.abstr-s6-t3", "normalized": [] }, { "id": "DerGynaekologe.90320518.eng.abstr-s2-r4-t1.1-t1.2", "type": "measures", "arg1_id": "DerGynaekologe.90320518.eng.abstr-s6-t1", "arg2_id": "DerGynaekologe.90320518.eng.abstr-s2-t1", "normalized": [] }, { "id": "DerGynaekologe.90320518.eng.abstr-s2-r5-t5.1-t1.1", "type": 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DerGynaekologe.90320529.eng.abstr	DerGynaekologe.90320529.eng.abstr	[ { "id": "DerGynaekologe.90320529.eng.abstr-passage-0", "type": "abstract", "text": [ "Chemotherapy-induced febrile neutropenia makes the immuncompromized cancer patient even more susceptible to severe infections . The risk of infections correlates with grade and duration of febrile neutropenia . Empiric antibiotic treatment can diminish the high infection-associated mortality . There are guidelines for antimicrobial treatment and modifications of therapy . To individualize therapy decisions , it is helpful to characterize high- and low-risk patients . Antibiotic prophylaxis in afebrile neutropenic patients is only indicated in special cases . Use of G-CSF for prophylaxis of neutropenia can be recommended for high-risk patients , but it should not be used for the treatment of infection ." ], "offsets": [ [ 0, 711 ] ] } ]	[ { "id": "DerGynaekologe.90320529.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "febrile" ], "offsets": [ [ 21, 28 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015967" } ] }, { "id": "DerGynaekologe.90320529.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "neutropenia" ], "offsets": [ [ 29, 40 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027947" } ] }, { "id": "DerGynaekologe.90320529.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "cancer" ], "offsets": [ [ 68, 74 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006826" } ] }, { "id": "DerGynaekologe.90320529.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 75, 82 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerGynaekologe.90320529.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "infections" ], "offsets": [ [ 115, 125 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021311" } ] }, { "id": "DerGynaekologe.90320529.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "risk" ], "offsets": [ [ 132, 136 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "DerGynaekologe.90320529.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "infections" ], "offsets": [ [ 140, 150 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021311" } ] }, { "id": "DerGynaekologe.90320529.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "febrile" ], "offsets": [ [ 189, 196 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015967" } ] }, { "id": "DerGynaekologe.90320529.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "neutropenia" ], "offsets": [ [ 197, 208 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027947" } ] }, { "id": "DerGynaekologe.90320529.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "risk of" ], "offsets": [ [ 132, 139 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "DerGynaekologe.90320529.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "antibiotic" ], "offsets": [ [ 219, 229 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003232" } ] }, { "id": "DerGynaekologe.90320529.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 230, 239 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerGynaekologe.90320529.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "infection-associated" ], "offsets": [ [ 262, 282 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021311" } ] }, { "id": "DerGynaekologe.90320529.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "mortality" ], "offsets": [ [ 283, 292 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026566" }, { "db_name": "UMLS", "db_id": "C0026565" } ] }, { "id": "DerGynaekologe.90320529.eng.abstr-s4-t1", "type": "umlsterm", "text": [ 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], "offsets": [ [ 472, 494 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0282638" } ] }, { "id": "DerGynaekologe.90320529.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "Use" ], "offsets": [ [ 565, 568 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042153" } ] }, { "id": "DerGynaekologe.90320529.eng.abstr-s7-t2", "type": "umlsterm", "text": [ "G-CSF" ], "offsets": [ [ 572, 577 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0079459" } ] }, { "id": "DerGynaekologe.90320529.eng.abstr-s7-t3", "type": "umlsterm", "text": [ "prophylaxis" ], "offsets": [ [ 582, 593 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033107" } ] }, { "id": "DerGynaekologe.90320529.eng.abstr-s7-t4", "type": "umlsterm", "text": [ "neutropenia" ], "offsets": [ [ 597, 608 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027947" } ] }, { "id": "DerGynaekologe.90320529.eng.abstr-s7-t5", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 642, 650 ] ], "normalized": [ { "db_name": 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DerGynaekologe.90320540.eng.abstr	DerGynaekologe.90320540.eng.abstr	[ { "id": "DerGynaekologe.90320540.eng.abstr-passage-0", "type": "abstract", "text": [ "HIV infected women have an increased morbidity caused by acute and chronic urogenital infections and their sequels . Up to 2/3 of the patients develop symptoms of genital infections and in around 1/3 cervical neoplasia is diagnosed . In 1/4 chronic lower abdominal discomfort and late sequels of PID will arise . Although cervical carcinoma ( - 5 % ) fulfills already the AIDS definition , it manifests usually early in the course of the HIV disease and is rarely associated with other opportunistic diseases . Increased disturbances of menstruation like amenorrhoea ( 17 % ) or hypermenorrhoea has been observed . Major complication of prenancy are preterm labor ( - 15 % ) and preterm delivery . An increased progression of the maternal HIV disease in association with pregnancy has not been observed . Risks of perinatal HIV-1 infection of the fetus are associated either with an already advanced or progressing HIV infection of the mother indicated by high viral load , p24 antigenemia and low CD4+ cells or obstetrical events like preterm delivery , preterm labor , amnionitis , duration of rupture of membranes and labor and contamination of amniotic fluid with maternal blood . Maternofetal HIV-1 transmission can be reduced by antiretroviral prophylaxis of the mother and the fetus ( 6-8 % ) , by elective caesarian ( 4-6 % ) or most successfully by elective caesarian and antiretroviral prophylaxis ( 2 % ) ." ], "offsets": [ [ 0, 1417 ] ] } ]	[ { "id": "DerGynaekologe.90320540.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "HIV" ], "offsets": [ [ 0, 3 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019682" } ] }, { "id": "DerGynaekologe.90320540.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "women" ], "offsets": [ [ 13, 18 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043210" } ] }, { "id": "DerGynaekologe.90320540.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "morbidity" ], "offsets": [ [ 37, 46 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220880" }, { "db_name": "UMLS", "db_id": "C0026538" } ] }, { "id": "DerGynaekologe.90320540.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "infections" ], "offsets": [ [ 86, 96 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021311" } ] }, { "id": "DerGynaekologe.90320540.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "sequels" ], "offsets": [ [ 107, 114 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243089" } ] }, { "id": "DerGynaekologe.90320540.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 134, 142 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerGynaekologe.90320540.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "symptoms" ], "offsets": [ [ 151, 159 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0683368" } ] }, { "id": "DerGynaekologe.90320540.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "infections" ], "offsets": [ [ 171, 181 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021311" } ] }, { "id": "DerGynaekologe.90320540.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "neoplasia" ], "offsets": [ [ 209, 218 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": 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DerGynaekologe.90320552.eng.abstr	DerGynaekologe.90320552.eng.abstr	[ { "id": "DerGynaekologe.90320552.eng.abstr-passage-0", "type": "abstract", "text": [ "In the late seventies and early eighties the toxic shock syndrome ( TSS ) became epidemic among young menstruating women . A strong correlation was found between TSS and the rising popularity of hyperabsorbent tampons . Exotoxin-producing Staphylococcus aureus is seen as the main mediator of TSS in controlled clinical trials . Menstrual and nonmenstrual forms of TSS are differentiated . The nonmenstrual form is comparatively rare and has a high rate of mortality rate . Several studies showed that the overall incidence of menstrual and nonmenstrual TSS is approximately 1-3 cases per 100 000 persons . The leading symptoms are fever , hypotension , mucous membrane hyperemia , diffuse rashes , myalgias , vomiting and diarrhea . The severe form of the syndrome leads to multiorgan dysfunction . The streptococcal TSS ( STSS ) caused by group A Streptococci is clinically similar to the staphylococcal TSS . Both Staphylococcus aureus and Streptococci produce the exotoxin TSST-1. New methods allow the detection of TSST-1 production . However , due to the low incidence of TSS , this method of detection has not yet been taken up in the routine diagnostic procedures ." ], "offsets": [ [ 0, 1173 ] ] } ]	[ { "id": "DerGynaekologe.90320552.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "toxic" ], "offsets": [ [ 45, 50 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0600688" } ] }, { "id": "DerGynaekologe.90320552.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "shock" ], "offsets": [ [ 51, 56 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036974" } ] }, { "id": "DerGynaekologe.90320552.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "syndrome" ], "offsets": [ [ 57, 65 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "DerGynaekologe.90320552.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "TSS" ], "offsets": [ [ 68, 71 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0600327" } ] }, { "id": "DerGynaekologe.90320552.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "epidemic" ], "offsets": [ [ 81, 89 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014499" }, { "db_name": "UMLS", "db_id": "C0220823" } ] }, { "id": "DerGynaekologe.90320552.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "women" ], "offsets": [ [ 115, 120 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043210" } ] }, { "id": "DerGynaekologe.90320552.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "toxic shock" ], "offsets": [ [ 45, 56 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0600327" } ] }, { "id": "DerGynaekologe.90320552.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "toxic shock syndrome" ], "offsets": [ [ 45, 65 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0600327" } ] }, { "id": "DerGynaekologe.90320552.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "TSS" ], "offsets": [ [ 162, 165 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0600327" } ] }, { "id": "DerGynaekologe.90320552.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "tampons" ], "offsets": [ [ 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DerGynaekologe.90320594.eng.abstr	DerGynaekologe.90320594.eng.abstr	[ { "id": "DerGynaekologe.90320594.eng.abstr-passage-0", "type": "abstract", "text": [ "In adjuvant therapy of breast cancer , instead of individualized chemotherapy regimens there is a tendency towards more aggressive protocols in patients with high risk of recurrence . In this context even therapy-related mortality is accepted because therapy may be curative . In contrast , chemotherapy for metastatic disease mainly aims at palliation . Reduction of therapy-related side effects is one of the major endpoints of clinical trials in stage IV breast cancer . Routine follow-up procedures that do not aim at early diagnosis of metastatic disease , but at the diagnosis of symptomatic metastases , further reflect this therapeutic strategy . During recent years this paradigm has been challenged by two new developments . On the one hand , new therapies like high-dose chemotherapy with stem-cell support may allow long-term survival for certain subgroups of patients with metastatic disease . On the other hand , the refinement of diagnostic procedures may allow \" metastatic disease \" to be detected in breast cancer that , according to TNM staging , is classified as early breast cancer . This and the concept of \" micrometastases \" that are treated by adjuvant therapy imply that by conventional staging with chest X-ray , liver ultrasound and bone scans somehow artificially two different stages of the same disease are defined . Even if the biology of metastasis or the refinement of diagnostic procedures is of great interest , routine therapeutic strategies must be guided by the results from clinical trials that mainly deal with metastatic breast cancer as defined by conventional staging procedures . Every modification of this definition , even if it reflects more intimate understanding of the disease , must be evaluated in prospective randomized clinical trials ." ], "offsets": [ [ 0, 1791 ] ] } ]	[ { "id": "DerGynaekologe.90320594.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "adjuvant" ], "offsets": [ [ 3, 11 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001551" } ] }, { "id": "DerGynaekologe.90320594.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 12, 19 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerGynaekologe.90320594.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "breast" ], "offsets": [ [ 23, 29 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006141" }, { "db_name": "UMLS", "db_id": "C0006142" } ] }, { "id": "DerGynaekologe.90320594.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "cancer" ], "offsets": [ [ 30, 36 ] ], "normalized": [ { "db_name": 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"db_id": "C0006142" } ] }, { "id": "DerGynaekologe.90320594.eng.abstr-s1-t10", "type": "umlsterm", "text": [ "risk of" ], "offsets": [ [ 163, 170 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "DerGynaekologe.90320594.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "therapy-related" ], "offsets": [ [ 205, 220 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerGynaekologe.90320594.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "mortality" ], "offsets": [ [ 221, 230 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026566" }, { "db_name": "UMLS", "db_id": "C0026565" } ] }, { "id": "DerGynaekologe.90320594.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 251, 258 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerGynaekologe.90320594.eng.abstr-s3-t1", "type": "umlsterm", "text": [ 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DerGynaekologe.90320597.eng.abstr	DerGynaekologe.90320597.eng.abstr	[ { "id": "DerGynaekologe.90320597.eng.abstr-passage-0", "type": "abstract", "text": [ "In 10-30 % of cases , locoregional recurrence is accompanied by distant metastasis ; a further 25 % develop distant metastasis within the year after diagnosis of recurrence . In treatment of recurrent tumor in the thoracic wall , axillary or supraclavicular disease surgery plays a major role . Since - another long-lasting courses occur even in the metastatic situation , recurrence is not an infrequent event , and therapy then needs a multidisciplinary approach . Surgical techniques such as local , myocutaneous or omental flaps and mesh graft transplantation are used to cover large defects after tumor resection . Additional and innovative modalities are combined in the management of this complex problem : locoregional or systemic chemotherapy , topical application of chemotherapy , certain radiation regimens and in otherwise resistant tumors the experimental use of photodynamic laser therapy ( PDT ) . The most important goal hereby is to restore or at least maintain organ function and quality of life ." ], "offsets": [ [ 0, 1016 ] ] } ]	[ { "id": "DerGynaekologe.90320597.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "recurrence" ], "offsets": [ [ 35, 45 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034897" } ] }, { "id": "DerGynaekologe.90320597.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "metastasis" ], "offsets": [ [ 72, 82 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027627" } ] }, { "id": "DerGynaekologe.90320597.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "metastasis" ], "offsets": [ [ 116, 126 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027627" } ] }, { "id": "DerGynaekologe.90320597.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "diagnosis" ], "offsets": [ [ 149, 158 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011900" }, { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerGynaekologe.90320597.eng.abstr-s1-t5", "type": 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DerGynaekologe.90320605.eng.abstr	DerGynaekologe.90320605.eng.abstr	[ { "id": "DerGynaekologe.90320605.eng.abstr-passage-0", "type": "abstract", "text": [ "There are plenty of endocrine agents available for patients with advanced breast cancer . They have good therapeutic evidence and show fewer side effects in women with hormone-receptor-positive tumors , as well as in a smaller percentage of patients with receptor negative tumors . Application of endocrine agents follows defined indications . They are given sequentially with the least toxic therapy given first . The suppression of estrogen synthesis with GnRH analogues is the first step of treatment for premenopausal patients . If the tumor progresses , the sequential application for premenopausal patients is the same as for postmenopausal women with continuous application of GnRH analogues . Antiestrogen tamoxifen is considered the first-line endocrine therapy for postmenopausal advanced breast cancer . Alternatively , Toremifen shows the same effectiveness and side effects as tamoxifen . Although it is postulated that is less carcinogenic , this must be demonstrated conclusively in long-term follow-up . The aromatase inhibitors are defined as second-line endocrine therapy . Newer selective aromatase inhibitors such as formestane , letrozole and anastrozole are p . o . active and have substituted classical aminoglutethimide . There are numerous new aromatase inhibitors that will be investigated in clinical trials of advanced and primary breast cancer . Progestins are given as third-line endocrine therapy . They have a high risk of thromboembolic complications , but good palliative and supportive effect . Antiprogestins , androgens and antiandrogens are still under investigation and have so far shown only limited success in clinical trials ." ], "offsets": [ [ 0, 1668 ] ] } ]	[ { "id": "DerGynaekologe.90320605.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 51, 59 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerGynaekologe.90320605.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "breast" ], "offsets": [ [ 74, 80 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006141" }, { "db_name": "UMLS", "db_id": "C0006142" } ] }, { "id": "DerGynaekologe.90320605.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "cancer" ], "offsets": [ [ 81, 87 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006826" } ] }, { "id": "DerGynaekologe.90320605.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "breast cancer" ], "offsets": [ [ 74, 87 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006142" } ] }, { "id": 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Several new substances are efficient in breast-cancer patients and should be evaluated for further clinical use in future studies ." ], "offsets": [ [ 0, 658 ] ] } ]	[ { "id": "DerGynaekologe.90320614.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "use" ], "offsets": [ [ 4, 7 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042153" } ] }, { "id": "DerGynaekologe.90320614.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 21, 28 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerGynaekologe.90320614.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "metastatic" ], "offsets": [ [ 32, 42 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036525" } ] }, { "id": "DerGynaekologe.90320614.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "breast" ], "offsets": [ [ 43, 49 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006141" }, { "db_name": "UMLS", "db_id": "C0006142" } ] }, { "id": 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DerGynaekologe.90320632.eng.abstr	DerGynaekologe.90320632.eng.abstr	[ { "id": "DerGynaekologe.90320632.eng.abstr-passage-0", "type": "abstract", "text": [ "Even today metastatic breast cancer remains incurable disease . Therefore most clinical trials in the last decade aimed at an improvement of the therapeutical ratio . In this context high-dose chemotherapy with therapy related mortality of 2 %-5 % seems to be justified only if long term survival or relevant prolongation of progression free survival is attainable . Survival data from early phase I-II trials show the same initial high relapse rates as after conventional chemotherapy . On the contrary , HDC data from the early 80 s suggest that after three years survival plateaus at 14 %-20 % long term survivors . Data from European and American transplant registries reporting about 4000 patients show the same trend . For the whole population the survival advantage by high dose chemotherapy is estimated to be about one year . Maximum benefit is demonstrable in patients with chemosensitive disease . Data from one phase III trial comparing early tandem HDC with conventional chemotherapy show significant survival advantages for the HDC group with 20 % survivors at 400 weeks . Data from other phase III trials will be published in 1999. In Germany patients can be randomized to two ongoing prospective randomized trials ." ], "offsets": [ [ 0, 1231 ] ] } ]	[ { "id": "DerGynaekologe.90320632.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "metastatic" ], "offsets": [ [ 11, 21 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036525" } ] }, { "id": "DerGynaekologe.90320632.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "breast" ], "offsets": [ [ 22, 28 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006141" }, { "db_name": "UMLS", "db_id": "C0006142" } ] }, { "id": "DerGynaekologe.90320632.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "cancer" ], "offsets": [ [ 29, 35 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006826" } ] }, { "id": "DerGynaekologe.90320632.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 54, 61 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerGynaekologe.90320632.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "breast 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When he realised that he had caused the death of so many women in childbirth , Michaelis was desperate and committed suicide in 1848." ], "offsets": [ [ 0, 837 ] ] } ]	[ { "id": "DerGynaekologe.90320660.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Hospital" ], "offsets": [ [ 72, 80 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019994" } ] }, { "id": "DerGynaekologe.90320660.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "School" ], "offsets": [ [ 89, 95 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036375" } ] }, { "id": "DerGynaekologe.90320660.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "Midwifery" ], "offsets": [ [ 99, 108 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026082" } ] }, { "id": "DerGynaekologe.90320660.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "obstetrics" ], "offsets": [ [ 173, 183 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028773" } ] }, { "id": "DerGynaekologe.90320660.eng.abstr-s2-t1", "type": "umlsterm", "text": [ 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"offsets": [ [ 434, 443 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033325" } ] }, { "id": "DerGynaekologe.90320660.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "birth" ], "offsets": [ [ 462, 467 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005615" } ] }, { "id": "DerGynaekologe.90320660.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "researcher" ], "offsets": [ [ 493, 503 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035173" } ] }, { "id": "DerGynaekologe.90320660.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "Germany" ], "offsets": [ [ 598, 605 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017480" } ] }, { "id": "DerGynaekologe.90320660.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "prophylaxis" ], "offsets": [ [ 659, 670 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033107" } ] }, { "id": "DerGynaekologe.90320660.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "puerperal" ], "offsets": [ [ 674, 683 ] ], "normalized": [ { "db_name": 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DerGynaekologe.90320666.eng.abstr	DerGynaekologe.90320666.eng.abstr	[ { "id": "DerGynaekologe.90320666.eng.abstr-passage-0", "type": "abstract", "text": [ "The liver is one of the most involved organs in the case of hematogenous metastases of breast carcinoma . In strictly intrahepatic involvement of breast cancer local ablative methods like surgical resection and minimal-invasive treatment modalities are discussed when systemic chemo- or hormone therapies are ineffective . In the clinical programme 51 patients with secondary metastastic involvement of the liver due to breast carcinoma were prospectively treated via MR-guided laser-induced thermotherapy in an outpatient setting . Patients were included with a maximum of five lesions up to a maximum diameter of 5 cm . Patients with additional extrahepatic involvement are excluded . MR-guided LITT allowed local tumor control in the liver at three months of 89.2 % and at six months of 79.1 % . The cumulative median survival rate was 50,29 months ( confidence interval 95 % , 41.99-42.22 months ) . MR-guided LITT allows high local tumor control . Possible indications for the treatment with LITT are patients with strictly intrahepatic metastases who are not demonstrating a complete response after chemo- or hormone therapy ." ], "offsets": [ [ 0, 1132 ] ] } ]	[ { "id": "DerGynaekologe.90320666.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "liver" ], "offsets": [ [ 4, 9 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0345904" }, { "db_name": "UMLS", "db_id": "C0023884" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "metastases" ], "offsets": [ [ 73, 83 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027627" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "breast" ], "offsets": [ [ 87, 93 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006141" }, { "db_name": "UMLS", "db_id": "C0006142" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "carcinoma" ], "offsets": [ [ 94, 103 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007097" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "breast" ], "offsets": [ [ 146, 152 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006141" }, { "db_name": "UMLS", "db_id": "C0006142" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "cancer" ], "offsets": [ [ 153, 159 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006826" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "methods" ], "offsets": [ [ 175, 182 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "surgical" ], "offsets": [ [ 188, 196 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 228, 237 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "hormone" ], "offsets": [ [ 287, 294 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019932" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s2-t7", "type": "umlsterm", "text": [ "therapies" ], "offsets": [ [ 295, 304 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s2-t8", "type": "umlsterm", "text": [ "breast cancer" ], "offsets": [ [ 146, 159 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006142" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 352, 360 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "secondary" ], "offsets": [ [ 366, 375 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027627" }, { "db_name": "UMLS", "db_id": "C0036525" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "liver" ], "offsets": [ [ 407, 412 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0345904" }, { "db_name": "UMLS", "db_id": "C0023884" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "breast" ], "offsets": [ [ 420, 426 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006141" }, { "db_name": "UMLS", "db_id": "C0006142" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "carcinoma" ], "offsets": [ [ 427, 436 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007097" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "thermotherapy" ], "offsets": [ [ 492, 505 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020548" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s3-t7", "type": "umlsterm", "text": [ "outpatient" ], "offsets": [ [ 512, 522 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029921" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "Patients" ], "offsets": [ [ 533, 541 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "Patients" ], "offsets": [ [ 622, 630 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "tumor" ], "offsets": [ [ 716, 721 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "control" ], "offsets": [ [ 722, 729 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243148" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "liver" ], "offsets": [ [ 737, 742 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0345904" }, { "db_name": "UMLS", "db_id": "C0023884" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "survival" ], "offsets": [ [ 821, 829 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220921" }, { "db_name": "UMLS", "db_id": "C0038952" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s7-t2", "type": "umlsterm", "text": [ "survival rate" ], "offsets": [ [ 821, 834 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038954" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s7-t3", "type": "umlsterm", "text": [ "confidence interval" ], "offsets": [ [ 854, 873 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009667" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s8-t1", "type": "umlsterm", "text": [ "tumor" ], "offsets": [ [ 937, 942 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": 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DerGynaekologe.90320675.eng.abstr	DerGynaekologe.90320675.eng.abstr	[ { "id": "DerGynaekologe.90320675.eng.abstr-passage-0", "type": "abstract", "text": [ "Like other metastases , bone metastases in breast cancer patients are not only a sign of the incurable nature of the underlying disease , but are also associated with specific complications . In particular , bone pain and pathological fractures impair the quality of life of those affected . Any treatment concept must therefore place the highest priority on preventing or reducing skeletal complications . There are two treatment options - local and systemic . Local therapy includes radiotherapy as well as surgical and orthopedic measures . The four pillars of systemic treatment are hormone therapy and chemotherapy , antiresorptive therapy with bisphosphonates and treatment with centrally and/or peripherally acting analgesics . A precondition for successful treatment is close cooperation between gynecologists , internists/oncologists , radiotherapists , surgeons/orthopedists , pain specialists and endocrinologists ( in the presence of a hypercalcemic syndrome ) . Patients with breast cancer associated solely with osseous metastasis may survive for a number of years . It is therefore all the more important to start appropriate therapeutic measures in good time . Bisphosphonates play a particularly valuable role , since their main effect lies in the prevention of skeletal complications . Rather than replacing antineoplastic therapy , this class of substances supplements other treatments . Once started , bisphosphonate therapy should be given life-long , even in the event of osseous progression ." ], "offsets": [ [ 0, 1515 ] ] } ]	[ { "id": "DerGynaekologe.90320675.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "metastases" ], "offsets": [ [ 11, 21 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027627" } ] }, { "id": "DerGynaekologe.90320675.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "bone" ], "offsets": [ [ 24, 28 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0262950" } ] }, { "id": "DerGynaekologe.90320675.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "metastases" ], "offsets": [ [ 29, 39 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027627" } ] }, { "id": "DerGynaekologe.90320675.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "breast" ], "offsets": [ [ 43, 49 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006141" }, { "db_name": "UMLS", "db_id": "C0006142" } ] }, { "id": "DerGynaekologe.90320675.eng.abstr-s1-t5", "type": 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"normalized": [ { "db_name": "UMLS", "db_id": "C0009566" } ] }, { "id": "DerGynaekologe.90320675.eng.abstr-s1-t11", "type": "umlsterm", "text": [ "breast cancer" ], "offsets": [ [ 43, 56 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006142" } ] }, { "id": "DerGynaekologe.90320675.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "bone" ], "offsets": [ [ 208, 212 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0262950" } ] }, { "id": "DerGynaekologe.90320675.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 213, 217 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerGynaekologe.90320675.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "fractures" ], "offsets": [ [ 235, 244 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016658" } ] }, { "id": "DerGynaekologe.90320675.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "life" ], "offsets": [ [ 267, 271 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376558" } ] }, { 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DerGynaekologe.90320683.eng.abstr	DerGynaekologe.90320683.eng.abstr	[ { "id": "DerGynaekologe.90320683.eng.abstr-passage-0", "type": "abstract", "text": [ "Brain metastases are life-threatening events for patients . Adequate therapeutic strategies demand thoughtful planning and careful weighting of all treatment options . Multiple brain metastases should be treated in palliative therapy with whole-brain irradiation . In patients with a favourable prognosis and solitary or few brain metastases , surgical excision and radiosurgery are comparable adequate treatment options . Radiosurgery is an non-invasive procedure that can also be performed in non-operable brain areas . The value of additional whole-brain irradiation is under discussion . It has no influence on survival , but the frequence of new brain metastases may be reduced ." ], "offsets": [ [ 0, 684 ] ] } ]	[ { "id": "DerGynaekologe.90320683.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Brain" ], "offsets": [ [ 0, 5 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0153633" }, { "db_name": "UMLS", "db_id": "C0006104" }, { "db_name": "UMLS", "db_id": "C0496899" } ] }, { "id": "DerGynaekologe.90320683.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "metastases" ], "offsets": [ [ 6, 16 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027627" } ] }, { "id": "DerGynaekologe.90320683.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 49, 57 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerGynaekologe.90320683.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "therapeutic" ], "offsets": [ [ 69, 80 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": 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DerGynaekologe.90320705.eng.abstr	DerGynaekologe.90320705.eng.abstr	[ { "id": "DerGynaekologe.90320705.eng.abstr-passage-0", "type": "abstract", "text": [ "The title of this paper poses a question to which the short answer must be \" yes \" . What oncologist would not wish to be in the enviable position of an infectious diseases physician , who can treat a patient with a serious infection knowing that the organism is sensitive to the antibiotic prescribed ? Unfortunately , cancer cells are not as easy to grow as most bacteria and previous attempts to produce a feasible chemosensitivity assay for clinical use have been largely unsuccessful . Yet the rationale for such assays is sound : not all tumors of one histological type respond in the same way to the same agent . We know that this heterogeneity reflects the molecular phenotype . Over the last 8 years , a new tumor chemosensitivity assay ( ATP-TCA ) based on highly sensitive luminescence technology has been developed to the point where it is now entering phase III trials in ovarian cancer . Results in breast cancer are similarly encouraging , although as yet few patients have been treated prospectively according to the results of the assay . The assay has 97 % evaluability for surgical biopsies with 76 % concordance between clinical response and chemosensitivity . Results from neoadjuvant studies in which needle biopsies and tumor from the mastectomy specimen obtained after three cycles in six cases were tested show the rapid development of resistance in four cases to combination chemotherapy . However , nine courses of chemotherapy given on the basis of the ATP-TCA resulted in partial or complete responses in all nine patients . Phase III clinical trials of ATP-TCA directed therapy against empirical therapy are in progress ." ], "offsets": [ [ 0, 1651 ] ] } ]	[ { "id": "DerGynaekologe.90320705.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "paper" ], "offsets": [ [ 18, 23 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030351" } ] }, { "id": "DerGynaekologe.90320705.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "diseases" ], "offsets": [ [ 164, 172 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerGynaekologe.90320705.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "physician" ], "offsets": [ [ 173, 182 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031831" } ] }, { "id": "DerGynaekologe.90320705.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 201, 208 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerGynaekologe.90320705.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "infection" ], "offsets": [ [ 224, 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DerGynaekologe.90320710.eng.abstr	DerGynaekologe.90320710.eng.abstr	[ { "id": "DerGynaekologe.90320710.eng.abstr-passage-0", "type": "abstract", "text": [ "For patients with carcinoma of the breast the detection of distant metastases means that definitive recovery is no longer possible , since any further treatment can only be palliative in nature . Consequently , the holistic approach of palliative medicine centres on the patients ' quality of life , which is determined not only by their physical condition but also by their level of psychosocial wellbeing . In view of the pain experienced by 75 % of patients with metastatic mammary carcinoma and the effect of pain on their general wellbeing , adequate pain therapy , which can almost always be given by the oral route , so that outpatient treatment is possible , is the first priority . In addition , therapeutic control of other symptoms associated with the tumor or with the treatment is of fundamental importance . Care of these patients makes particular personal demands on the doctors , care staff , etc. , to enable them to provide psychological and human support for those incurable patients in the final stage of their life ." ], "offsets": [ [ 0, 1037 ] ] } ]	[ { "id": "DerGynaekologe.90320710.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 4, 12 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerGynaekologe.90320710.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "carcinoma" ], "offsets": [ [ 18, 27 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007097" } ] }, { "id": "DerGynaekologe.90320710.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "breast" ], "offsets": [ [ 35, 41 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006141" }, { "db_name": "UMLS", "db_id": "C0006142" } ] }, { "id": "DerGynaekologe.90320710.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "metastases" ], "offsets": [ [ 67, 77 ] ], "normalized": [ { 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DerGynaekologe.90320753.eng.abstr	DerGynaekologe.90320753.eng.abstr	[ { "id": "DerGynaekologe.90320753.eng.abstr-passage-0", "type": "abstract", "text": [ "Pregnancy-induced hypertension and preeclampsia account for nearly 25 % of perinatal morbidity and mortality and are a leading cause of maternal death in developed countries . Consequently , early detection of women with a higher risk is helpful for intensified prenatal care . Since therapeutic options exist in some cases , screening for risk factors is required . Risk factors include parity , medical history , and family history . Laboratory tests of haemostasis and the detection of autoimmune disease complete adequate screening . More than 100 methods have been tested for the prediction of preeclampsia in the second trimester . Results obtained by Doppler ultrasound appear to be more reliable than most clinical parameters . However , no test presently available can really serve as a useful early marker of developing preeclampsia . More specific methods detecting endothelial dysfunction and platelet activation are being developed and might provide improved prediction ." ], "offsets": [ [ 0, 984 ] ] } ]	[ { "id": "DerGynaekologe.90320753.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "hypertension" ], "offsets": [ [ 18, 30 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020538" } ] }, { "id": "DerGynaekologe.90320753.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "preeclampsia" ], "offsets": [ [ 35, 47 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032914" } ] }, { "id": "DerGynaekologe.90320753.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "morbidity" ], "offsets": [ [ 85, 94 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220880" }, { "db_name": "UMLS", "db_id": "C0026538" } ] }, { "id": "DerGynaekologe.90320753.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "mortality" ], "offsets": [ [ 99, 108 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026566" }, { "db_name": "UMLS", "db_id": "C0026565" } ] }, { "id": "DerGynaekologe.90320753.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "cause" ], "offsets": [ [ 127, 132 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015127" } ] }, { "id": "DerGynaekologe.90320753.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "death" ], "offsets": [ [ 145, 150 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011065" } ] }, { "id": "DerGynaekologe.90320753.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "maternal death" ], "offsets": [ [ 136, 150 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024923" } ] }, { "id": "DerGynaekologe.90320753.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "developed countries" ], "offsets": [ [ 154, 173 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0282613" } ] }, { "id": "DerGynaekologe.90320753.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "women" ], "offsets": [ [ 210, 215 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043210" } ] }, { "id": "DerGynaekologe.90320753.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "risk" ], "offsets": [ [ 230, 234 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "DerGynaekologe.90320753.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "care" ], "offsets": [ [ 271, 275 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0150499" } ] }, { "id": "DerGynaekologe.90320753.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "prenatal care" ], "offsets": [ [ 262, 275 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033052" } ] }, { "id": "DerGynaekologe.90320753.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "therapeutic" ], "offsets": [ [ 284, 295 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "DerGynaekologe.90320753.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "risk" ], "offsets": [ [ 340, 344 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "DerGynaekologe.90320753.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "risk factors" ], "offsets": [ [ 340, 352 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035648" } ] }, { "id": "DerGynaekologe.90320753.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "Risk" ], "offsets": [ [ 367, 371 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "DerGynaekologe.90320753.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "parity" ], "offsets": [ [ 388, 394 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030563" } ] }, { "id": "DerGynaekologe.90320753.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "history" ], "offsets": [ [ 405, 412 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019664" }, { "db_name": "UMLS", "db_id": "C0019665" } ] }, { "id": "DerGynaekologe.90320753.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "family" ], "offsets": [ [ 419, 425 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015576" } ] }, { "id": "DerGynaekologe.90320753.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "history" 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DerGynaekologe.90320768.eng.abstr	DerGynaekologe.90320768.eng.abstr	[ { "id": "DerGynaekologe.90320768.eng.abstr-passage-0", "type": "abstract", "text": [ "Endothelially derived nitric oxide ( NO ) regulates vasodilatation via relaxation of the smooth muscle cells and inhibits platelet aggregation in addition to a number of other biological processes . Animal experiments have provided evidence for increased NO production in the normal pregnancy . This contributes to the decrease in peripheral vascular resistance and to the increased glomerular filtration rate . Inhibition of NO synthesis is associated with a preeclampsia-like syndrome in various animal species . In vivo and in vitro data in the human pregnancy have indicated that NO deficiency contributes to the vasoconstriction seen in preeclampsia . However , due to the short half-life time of NO , pharmacological application is only possible by NO-donating drugs such as glycerol trinitrate ( GTN , \" nitroglycerine \" ) , isosorbide dinitrate ( ISDN ) , isosorbide mononitrate ( ISMN ) or S-nitrosoglutathion ( GSNO ) . There is limited experience with the use of NO donors in human pregnancy ; yet no teratogenic or embryotoxic effects are reported . According to current knowledge , transdermal application of GTN in pregnancy is safe with only minor effects on maternal blood pressure and without compromising the uteroplacental perfusion in patients with preeclampsia . Up to now only one prospective randomized trial has been conducted on the prophylaxis of preeclampsia by NO donors in women at high risk for development of the disease . However , the sample size of this study was too small to allow final conclusions . There are no randomized trials on the therapy of preeclampsia by NO donors reported in the literature . Therefore , it is that the use of NO donors be evaluated in the prophylaxis and therapy of preeclampsia only recommended in the context of clinical trials ." ], "offsets": [ [ 0, 1797 ] ] } ]	[ { "id": "DerGynaekologe.90320768.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "oxide" ], "offsets": [ [ 29, 34 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030015" } ] }, { "id": "DerGynaekologe.90320768.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "vasodilatation" ], "offsets": [ [ 52, 66 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042401" } ] }, { "id": "DerGynaekologe.90320768.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "relaxation" ], "offsets": [ [ 71, 81 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035028" } ] }, { "id": "DerGynaekologe.90320768.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "muscle" ], "offsets": [ [ 96, 102 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026845" } ] }, { "id": "DerGynaekologe.90320768.eng.abstr-s1-t5", "type": 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DerGynaekologe.90320776.eng.abstr	DerGynaekologe.90320776.eng.abstr	[ { "id": "DerGynaekologe.90320776.eng.abstr-passage-0", "type": "abstract", "text": [ "There is little to suggest that the course of preeclamsia can be substantially affected by drug treatment . The vast majority of randomized studies do not indicate beneficial effects of antihypertensive treatment on proteinuria , fetal heart rate abnormalities , abruptio placentae and the incidence of preterm birth . There is also no definite effect on the development of superimposed preeclampsia , HELLP syndrome , renal failure or eclampsia . Moreover , blood pressure lowering agents fail to improve uteroplacental perfusion but may have adverse effects on fetal growth . Antihypertensive treatment is only indicated in severe hypertension ( > 170/110 mm Hg ) to reduce the risk of cerebral hemorrhage . Dihydralazine injections may result in reduced placental blood flow and fetal distress . Oral nifedipine offers some advantages in view of more potent vasodilator actions on uterine and fetoplacental vessels and a lower incidence of fetal distress . Increasing evidence suggests that the mechanism of eclamptic seizure is cerebral vasoconstriction with resultant ischemia . Cerebral vessels are particularly sensitive to magnesium , which works by reversing cerebral vasoconstriction with resultant improvement in blood flow . Controlled trials have shown magnesium to be superior to both placebo and phenytoin for the prevention of eclampsia . Furthermore , magnesium has been found to be more effective than diazepam and phenytoin in preventing recurrence of seizures in women with eclampsia . Also the neonatal outcome favors magnesium , which is now generally accepted as the drug of choice for the prevention and treatment of eclampsia ." ], "offsets": [ [ 0, 1652 ] ] } ]	[ { "id": "DerGynaekologe.90320776.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "drug" ], "offsets": [ [ 91, 95 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013227" } ] }, { "id": "DerGynaekologe.90320776.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 96, 105 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerGynaekologe.90320776.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "antihypertensive" ], "offsets": [ [ 186, 202 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003364" } ] }, { "id": "DerGynaekologe.90320776.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 203, 212 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerGynaekologe.90320776.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "proteinuria" ], "offsets": [ [ 216, 227 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033687" } ] }, { "id": "DerGynaekologe.90320776.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "heart" ], "offsets": [ [ 236, 241 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018787" } ] }, { "id": "DerGynaekologe.90320776.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "abnormalities" ], "offsets": [ [ 247, 260 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000768" }, { "db_name": "UMLS", "db_id": "C0000769" } ] }, { "id": "DerGynaekologe.90320776.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "placentae" ], "offsets": [ [ 272, 281 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032043" } ] }, { "id": "DerGynaekologe.90320776.eng.abstr-s2-t7", "type": "umlsterm", "text": [ "incidence" ], "offsets": [ [ 290, 299 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220856" }, { "db_name": "UMLS", "db_id": "C0021149" } ] }, { "id": "DerGynaekologe.90320776.eng.abstr-s2-t8", "type": "umlsterm", "text": [ "birth" ], "offsets": [ [ 311, 316 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005615" } ] }, { "id": "DerGynaekologe.90320776.eng.abstr-s2-t9", "type": "umlsterm", "text": [ "fetal heart" ], "offsets": [ [ 230, 241 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015935" } ] }, { "id": "DerGynaekologe.90320776.eng.abstr-s2-t10", "type": "umlsterm", "text": [ "heart rate" ], "offsets": [ [ 236, 246 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018810" } ] }, { "id": "DerGynaekologe.90320776.eng.abstr-s2-t11", "type": "umlsterm", "text": [ "abruptio placentae" ], "offsets": [ [ 263, 281 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000832" } ] }, { "id": "DerGynaekologe.90320776.eng.abstr-s2-t12", "type": "umlsterm", "text": [ "preterm birth" ], "offsets": [ [ 303, 316 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0151526" } ] }, { "id": "DerGynaekologe.90320776.eng.abstr-s2-t13", "type": "umlsterm", "text": [ "fetal heart rate" ], "offsets": [ [ 230, 246 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018811" } ] }, { "id": "DerGynaekologe.90320776.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "development" ], "offsets": [ [ 359, 370 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243107" }, { "db_name": "UMLS", "db_id": "C0020119" } ] }, { "id": "DerGynaekologe.90320776.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "preeclampsia" ], "offsets": [ [ 387, 399 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032914" } ] }, { "id": "DerGynaekologe.90320776.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "syndrome" ], "offsets": [ [ 408, 416 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "DerGynaekologe.90320776.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "eclampsia" ], "offsets": [ [ 436, 445 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013537" } ] }, { "id": "DerGynaekologe.90320776.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "HELLP syndrome" ], "offsets": [ [ 402, 416 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162739" } ] }, { "id": "DerGynaekologe.90320776.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "renal failure" ], "offsets": [ [ 419, 432 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035078" } ] }, { "id": "DerGynaekologe.90320776.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "blood" ], "offsets": [ [ 459, 464 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005767" }, { "db_name": "UMLS", "db_id": "C0005768" }, { "db_name": "UMLS", "db_id": "C0005835" } ] }, { "id": "DerGynaekologe.90320776.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "pressure" ], "offsets": [ [ 465, 473 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033095" } ] }, { "id": "DerGynaekologe.90320776.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "perfusion" ], "offsets": [ [ 521, 530 ] ], 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DerGynaekologe.90320783.eng.abstr	DerGynaekologe.90320783.eng.abstr	[ { "id": "DerGynaekologe.90320783.eng.abstr-passage-0", "type": "abstract", "text": [ "HELLP syndrome is characterized by a high incidence of fetal and maternal morbidity and mortality . It is known that the clinical and biochemical course in patients with HELLP syndrome improves spontaneously after prompt termination of pregnancy . The disadvantages of this regimen is the high rate of prematurity before the 32nd gestational week . In contrast to the routine recommendations , 12 studies including 330 patients have demonstrated that pregnancy prolongation in patients with HELLP syndrome may offer certain advantages . There is evidence that glucocorticosteroids may affect the course of HELLP syndrome before and even after the pregnancies are terminated . In 8 out of the 12 studies steroids were at least administered in some of the cases . Nevertheless , only a single randomized and controlled study was performed that demonstrated an effect in patients treated with steroids as compared to non-steroid-treated HELLP patients . Several additional studies have shown that puerperal recovery in patients with antepartum HELLP syndrome is accelerated if steroids are given . In contrast to evidence of the benefit of steroids , another study has demonstrated pregnancy prolongation in HELLP patients without the administration of glucocorticoids . In the future additional extensive studies should define inclusion criteria for pregnancy prolongation in patients with HELLP syndrome . Furthermore , the effect of different existing therapeutic regimes - particularly the effect of steroids - on the course of pregnancies complicated by HELLP syndrome should be investigated ." ], "offsets": [ [ 0, 1595 ] ] } ]	[ { "id": "DerGynaekologe.90320783.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "syndrome" ], "offsets": [ [ 6, 14 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "DerGynaekologe.90320783.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "incidence" ], "offsets": [ [ 42, 51 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220856" }, { "db_name": "UMLS", "db_id": "C0021149" } ] }, { "id": "DerGynaekologe.90320783.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "morbidity" ], "offsets": [ [ 74, 83 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220880" }, { "db_name": "UMLS", "db_id": "C0026538" } ] }, { "id": "DerGynaekologe.90320783.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "mortality" ], "offsets": [ [ 88, 97 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026566" }, { "db_name": "UMLS", "db_id": "C0026565" } ] }, { "id": "DerGynaekologe.90320783.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "HELLP syndrome" ], "offsets": [ [ 0, 14 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162739" } ] }, { "id": "DerGynaekologe.90320783.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 156, 164 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerGynaekologe.90320783.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "syndrome" ], "offsets": [ [ 176, 184 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "DerGynaekologe.90320783.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "pregnancy" ], "offsets": [ [ 236, 245 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "DerGynaekologe.90320783.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "HELLP syndrome" ], "offsets": [ [ 170, 184 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162739" } ] }, { "id": "DerGynaekologe.90320783.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "termination of pregnancy" ], "offsets": [ [ 221, 245 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000811" } ] }, { "id": "DerGynaekologe.90320783.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "prematurity" ], "offsets": [ [ 302, 313 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0270079" } ] }, { "id": "DerGynaekologe.90320783.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "contrast" ], "offsets": [ [ 352, 360 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0110625" } ] }, { "id": "DerGynaekologe.90320783.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "recommendations" ], "offsets": [ [ 376, 391 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034866" } ] }, { "id": "DerGynaekologe.90320783.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 419, 427 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerGynaekologe.90320783.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "pregnancy" ], "offsets": [ [ 451, 460 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "DerGynaekologe.90320783.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 477, 485 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerGynaekologe.90320783.eng.abstr-s4-t6", "type": "umlsterm", "text": [ "syndrome" ], "offsets": [ [ 497, 505 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "DerGynaekologe.90320783.eng.abstr-s4-t7", "type": "umlsterm", "text": [ "HELLP syndrome" ], "offsets": [ [ 491, 505 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162739" } ] }, { "id": "DerGynaekologe.90320783.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "syndrome" ], "offsets": [ [ 612, 620 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": 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DerGynaekologe.90320791.eng.abstr	DerGynaekologe.90320791.eng.abstr	[ { "id": "DerGynaekologe.90320791.eng.abstr-passage-0", "type": "abstract", "text": [ "The laboratory findings of hemolysis , elevated liver enzymes and low platelets are signs of an acute pregnancy complication often associated with abdominal pain and intrauterine growth retardation . A high coincidence with symptoms of preeclampsia is observed . The high rate of complications and the restitution of laboratory findings to normal values following cessation of pregnancy have led to the general recommendation of immediate delivery for about a decade . However , the fact that HELLP syndrome can also occur for up to 1 week post-partum and the results of studies on prolongation of pregnancy call this former concept of management into question , in particular , since there is a high rate of hemostasiological complications after cesarean section in acute HELLP syndrome . Because of the correlation of complications of HELLP syndrome with those of severe preeclampsia , the indication for delivery should be based on the signs of preeclampsia and additional clinical features . The results of studies on prolongation of pregnancies in HELLP syndrome and severe preeclampsia support this concept ." ], "offsets": [ [ 0, 1114 ] ] } ]	[ { "id": "DerGynaekologe.90320791.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "laboratory" ], "offsets": [ [ 4, 14 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022877" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "findings" ], "offsets": [ [ 15, 23 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243095" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "hemolysis" ], "offsets": [ [ 27, 36 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019054" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "liver" ], "offsets": [ [ 48, 53 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0345904" }, { "db_name": "UMLS", "db_id": "C0023884" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "enzymes" ], "offsets": [ [ 54, 61 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014442" }, { "db_name": "UMLS", "db_id": "C0014445" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "platelets" ], "offsets": [ [ 70, 79 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005821" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "signs" ], "offsets": [ [ 84, 89 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220912" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "pregnancy" ], "offsets": [ [ 102, 111 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s1-t9", "type": "umlsterm", "text": [ "complication" ], "offsets": [ [ 112, 124 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009566" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s1-t10", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 157, 161 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s1-t11", "type": "umlsterm", "text": [ "growth" ], "offsets": [ [ 179, 185 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018270" }, { "db_name": "UMLS", "db_id": "C0220844" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s1-t12", "type": "umlsterm", "text": [ "pregnancy complication" ], "offsets": [ [ 102, 124 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032962" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s1-t13", "type": "umlsterm", "text": [ "abdominal pain" ], "offsets": [ [ 147, 161 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000737" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s1-t14", "type": "umlsterm", "text": [ "intrauterine growth retardation" ], "offsets": [ [ 166, 197 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015934" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "symptoms" ], "offsets": [ [ 224, 232 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0683368" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "preeclampsia" ], "offsets": [ [ 236, 248 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032914" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "complications" ], "offsets": [ [ 280, 293 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009566" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "laboratory" ], "offsets": [ [ 317, 327 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022877" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "findings" ], "offsets": [ [ 328, 336 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243095" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "values" ], "offsets": [ [ 347, 353 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042295" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "pregnancy" ], "offsets": [ [ 377, 386 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "recommendation" ], "offsets": [ [ 411, 425 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034866" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s3-t7", "type": "umlsterm", "text": [ "delivery" ], "offsets": [ [ 439, 447 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011209" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s3-t8", "type": "umlsterm", "text": [ "normal values" ], "offsets": [ [ 340, 353 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086715" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "syndrome" ], "offsets": [ [ 499, 507 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "post-partum" ], "offsets": [ [ 540, 551 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086839" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "pregnancy" ], "offsets": [ [ 598, 607 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "complications" ], "offsets": [ [ 727, 740 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009566" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "syndrome" ], "offsets": [ [ 779, 787 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s4-t6", "type": "umlsterm", "text": [ "HELLP syndrome" ], "offsets": [ [ 493, 507 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162739" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s4-t7", "type": "umlsterm", "text": [ "cesarean section" ], "offsets": [ [ 747, 763 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007876" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s4-t8", "type": "umlsterm", "text": [ "HELLP syndrome" ], "offsets": [ [ 773, 787 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162739" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "complications" ], "offsets": [ [ 820, 833 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009566" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "syndrome" ], "offsets": [ [ 843, 851 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "preeclampsia" ], "offsets": [ [ 873, 885 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032914" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "delivery" ], "offsets": [ [ 907, 915 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011209" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s5-t5", "type": "umlsterm", "text": [ "signs" ], "offsets": [ [ 939, 944 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220912" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s5-t6", "type": "umlsterm", "text": [ "preeclampsia" ], "offsets": [ [ 948, 960 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032914" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s5-t7", "type": "umlsterm", "text": [ "HELLP syndrome" ], "offsets": [ [ 837, 851 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162739" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "pregnancies" ], "offsets": [ [ 1038, 1049 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "syndrome" ], "offsets": [ [ 1059, 1067 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "preeclampsia" ], "offsets": [ [ 1079, 1091 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032914" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "HELLP syndrome" ], "offsets": [ [ 1053, 1067 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162739" } ] } ]	[]	[]	[ { "id": "DerGynaekologe.90320791.eng.abstr-s1-r1-t2.1-t7.1", "type": "associated_with", "arg1_id": "DerGynaekologe.90320791.eng.abstr-s6-t2", "arg2_id": "DerGynaekologe.90320791.eng.abstr-s5-t7", "normalized": [] }, { "id": "DerGynaekologe.90320791.eng.abstr-s1-r2-t1.1-t14.1", "type": "causes", "arg1_id": "DerGynaekologe.90320791.eng.abstr-s6-t1", "arg2_id": "DerGynaekologe.90320791.eng.abstr-s1-t14", "normalized": 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DerGynaekologe.90320823.eng.abstr	DerGynaekologe.90320823.eng.abstr	[ { "id": "DerGynaekologe.90320823.eng.abstr-passage-0", "type": "abstract", "text": [ "Amniotic fluid is a major factor of the intrauterine environment , and deviation from the normal volume is associated with an increased perinatal morbidity and mortality . Polyhydramnios occurs in 0.2 to 1.6 % of pregnancies . It may be due to a number of congenital anomalies , an abnormal karyotype , maternal diabetes , Rh-disease or intrauterine infections potentially requiring non-invasive or invasive measures . However , the most common indication for prenatal intervention due to polyhydramnios is the Twin-Twin-Transfusion Syndrom ( TTTS ) . Treatment of polyhydramnios may focus on correction of the causative lesion , or symptomatic relief through drainage of amniotic fluid . Maternal administration of cyclooxygenase inhibitors represents a further , non-invasive therapeutic option . Indomethacin , Sulindac , or Nimesulide reduce the fetal urine output thus decreasing amniotic fluid volume over time without the risks associated with invasive procedures . However , potentially serious ductal constriction as well as a delay in the onset of amniotic fluid reduction have limited its application . Percutaneous amniotic fluid drainage may provide immediate reduction of intrauterine pressure , but is associated with a complication rate of 1 to 1.5 % . The hemodynamic characteristics of monochorionic pregnancies complicated by TTTS have led to the development of endoscopic laser coagulation of placental vascular anastomoses as a definitive treatment . Treatment is only required in a small minoritiy of pregnancies with polyhydramnios . Mild cases can be managed expectatively . Intrauterine pressure increases with an excessive increase in amniotic fluid volume ( AFI > 400 mm or MVP > 150 mm ) leads to the elevation of intrauterine pressure . Complications such as preterm premature rupture of membranes and preterm labor may lead to premature delivery . The main goal of prenatal treatment of polyhydramnios is thus the improvement of fetal outcome through prolongation of gestation and/or the alleviation of maternal symptoms ." ], "offsets": [ [ 0, 2052 ] ] } ]	[ { "id": "DerGynaekologe.90320823.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "environment" ], "offsets": [ [ 53, 64 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014406" } ] }, { "id": "DerGynaekologe.90320823.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "morbidity" ], "offsets": [ [ 146, 155 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220880" }, { "db_name": "UMLS", "db_id": "C0026538" } ] }, { "id": "DerGynaekologe.90320823.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "mortality" ], "offsets": [ [ 160, 169 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026566" }, { "db_name": "UMLS", "db_id": "C0026565" } ] }, { "id": "DerGynaekologe.90320823.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "Amniotic fluid" ], "offsets": [ [ 0, 14 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002638" } ] }, { "id": "DerGynaekologe.90320823.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "Polyhydramnios" ], "offsets": [ [ 172, 186 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020224" } ] }, { "id": "DerGynaekologe.90320823.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "pregnancies" ], "offsets": [ [ 213, 224 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "DerGynaekologe.90320823.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "congenital" ], "offsets": [ [ 256, 266 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009678" } ] }, { "id": "DerGynaekologe.90320823.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "anomalies" ], "offsets": [ [ 267, 276 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000769" } ] }, { "id": "DerGynaekologe.90320823.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "diabetes" ], "offsets": [ [ 312, 320 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011847" }, { "db_name": "UMLS", "db_id": "C0011849" } ] }, { "id": "DerGynaekologe.90320823.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "infections" ], "offsets": [ [ 350, 360 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021311" } ] }, { "id": "DerGynaekologe.90320823.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "measures" ], "offsets": [ [ 408, 416 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0079809" } ] }, { "id": "DerGynaekologe.90320823.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "congenital anomalies" ], "offsets": [ [ 256, 276 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0497552" }, { "db_name": "UMLS", "db_id": "C0000768" }, { "db_name": "UMLS", "db_id": "C0151491" } ] }, { "id": "DerGynaekologe.90320823.eng.abstr-s3-t7", "type": "umlsterm", "text": [ "maternal diabetes" ], "offsets": [ [ 303, 320 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0085207" } ] }, { "id": "DerGynaekologe.90320823.eng.abstr-s4-t1", "type": "umlsterm", 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"DerGynaekologe.90320823.eng.abstr-s14-r28-t7.1-t5.1", "type": "associated_with", "arg1_id": "DerGynaekologe.90320823.eng.abstr-s14-t7", "arg2_id": "DerGynaekologe.90320823.eng.abstr-s14-t5", "normalized": [] }, { "id": "DerGynaekologe.90320823.eng.abstr-s15-r1-t2.1-t4.1", "type": "associated_with", "arg1_id": "DerGynaekologe.90320823.eng.abstr-s15-t2", "arg2_id": "DerGynaekologe.90320823.eng.abstr-s15-t4", "normalized": [] }, { "id": "DerGynaekologe.90320823.eng.abstr-s15-r2-t2.1-t4.1", "type": "treats", "arg1_id": "DerGynaekologe.90320823.eng.abstr-s15-t2", "arg2_id": "DerGynaekologe.90320823.eng.abstr-s15-t4", "normalized": [] }, { "id": "DerGynaekologe.90320823.eng.abstr-s15-r3-t4.1-t2.1", "type": "associated_with", "arg1_id": "DerGynaekologe.90320823.eng.abstr-s15-t4", "arg2_id": "DerGynaekologe.90320823.eng.abstr-s15-t2", "normalized": [] } ]
DerGynaekologe.90320832.eng.abstr	DerGynaekologe.90320832.eng.abstr	[ { "id": "DerGynaekologe.90320832.eng.abstr-passage-0", "type": "abstract", "text": [ "The incidence of severe reduced amniotic fluid volume in the 2nd trimester is rare , but causes a dramatic rise in morbidity and mortality of the fetus . Since Gembruch and Hansmann [ 12 ] reported about their experiences with the diagnostic and therapeutic approach of amnioinfusion in 1988 there followed sporadic reports about amnioinfusion by other investigators . In the following the experiences with diagnostic and therapeutic amnioinfusion in the 2nd trimester and the technique will be disscussed ." ], "offsets": [ [ 0, 507 ] ] } ]	[ { "id": "DerGynaekologe.90320832.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "incidence" ], "offsets": [ [ 4, 13 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220856" }, { "db_name": "UMLS", "db_id": "C0021149" } ] }, { "id": "DerGynaekologe.90320832.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "morbidity" ], "offsets": [ [ 115, 124 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220880" }, { "db_name": "UMLS", "db_id": "C0026538" } ] }, { "id": "DerGynaekologe.90320832.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "mortality" ], "offsets": [ [ 129, 138 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026566" }, { "db_name": "UMLS", "db_id": "C0026565" } ] }, { "id": "DerGynaekologe.90320832.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "fetus" ], "offsets": [ [ 146, 151 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015965" } ] }, { "id": "DerGynaekologe.90320832.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "amniotic fluid" ], "offsets": [ [ 32, 46 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002638" } ] }, { "id": "DerGynaekologe.90320832.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "2nd trimester" ], "offsets": [ [ 61, 74 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032981" }, { "db_name": "UMLS", "db_id": "C0032979" }, { "db_name": "UMLS", "db_id": "C0032980" } ] }, { "id": "DerGynaekologe.90320832.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "diagnostic" ], "offsets": [ [ 231, 241 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerGynaekologe.90320832.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "therapeutic" ], "offsets": [ [ 246, 257 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "DerGynaekologe.90320832.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "investigators" ], "offsets": [ [ 353, 366 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035173" } ] }, { "id": "DerGynaekologe.90320832.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "diagnostic" ], "offsets": [ [ 407, 417 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerGynaekologe.90320832.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "therapeutic" ], "offsets": [ [ 422, 433 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "DerGynaekologe.90320832.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "technique" ], "offsets": [ [ 477, 486 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerGynaekologe.90320832.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "2nd trimester" ], "offsets": [ [ 455, 468 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032981" }, { "db_name": "UMLS", "db_id": "C0032979" }, { "db_name": "UMLS", "db_id": "C0032980" } ] } ]	[]	[]	[ { "id": "DerGynaekologe.90320832.eng.abstr-s1-r1-t4.1-t5.1", "type": "contains", "arg1_id": "DerGynaekologe.90320832.eng.abstr-s3-t4", "arg2_id": "DerGynaekologe.90320832.eng.abstr-s1-t5", "normalized": [] }, { "id": "DerGynaekologe.90320832.eng.abstr-s1-r2-t5.1-t4.1", "type": "surrounds", "arg1_id": "DerGynaekologe.90320832.eng.abstr-s1-t5", "arg2_id": "DerGynaekologe.90320832.eng.abstr-s3-t4", "normalized": [] }, { "id": "DerGynaekologe.90320832.eng.abstr-s2-r1-t3.1-t1.1", "type": "performs", "arg1_id": "DerGynaekologe.90320832.eng.abstr-s3-t3", "arg2_id": "DerGynaekologe.90320832.eng.abstr-s3-t1", "normalized": [] } ]
DerGynaekologe.90320855.eng.abstr	DerGynaekologe.90320855.eng.abstr	[ { "id": "DerGynaekologe.90320855.eng.abstr-passage-0", "type": "abstract", "text": [ "In this review the indications , techniques , results and perspectives of operative fetoscopy are described and discussed . Prenatal invasive therapy is indicated if postnatal therapy comes too late and fetal disease may lead to irreversible damage or death if it is left untreated . Potential candidates for intrauterine surgery are pregnancies with the following problems : diaphragmatic hernia , infravesical obstruction , sacrococcygeal teratoma , chorioangioma , neural tube defects , twin-twin transfusion syndrome and acardiac twin . The aim is to improve the intrauterine situation by minimally invasive surgery and to prevent irreversible damage . After delivery permanent repair is possible in cases with fetal malformations . Diaphragmatic hernia is the best example for the development from maximally invasive open fetal surgery to minimally invasive endoscopic surgery . There is still a lot of experimental work to be done , for example for the correction of diaphragmatic hernia and neural tube defects . However , in other areas such as severe second trimester twin-twin transfusion syndrome , endoscopic surgery is a well established technique in certain centres for fetal medicine . Endoscopic laser coagulation of the vascular placental anastomoses is a causal therapy and shows better results than serial amniodrainages . After 160 laser coagulations performed in our institution , the survival rates are as follows : overall 68 % of fetuses , with two survivors in 54 % and at least one survivor in 83 % of pregnancies ." ], "offsets": [ [ 0, 1541 ] ] } ]	[ { "id": "DerGynaekologe.90320855.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "review" ], "offsets": [ [ 8, 14 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0282443" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "techniques" ], "offsets": [ [ 33, 43 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "fetoscopy" ], "offsets": [ [ 84, 93 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015962" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 142, 149 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 176, 183 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 209, 216 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "death" ], "offsets": [ [ 252, 257 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011065" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "fetal disease" ], "offsets": [ [ 203, 216 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015929" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "surgery" ], "offsets": [ [ 322, 329 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038894" }, { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "pregnancies" ], "offsets": [ [ 334, 345 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "hernia" ], "offsets": [ [ 390, 396 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019270" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "teratoma" ], "offsets": [ [ 441, 449 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039538" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "chorioangioma" ], "offsets": [ [ 452, 465 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018916" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "defects" ], "offsets": [ [ 480, 487 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243067" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s3-t7", "type": "umlsterm", "text": [ "twin-twin" ], "offsets": [ [ 490, 499 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0041426" }, { "db_name": "UMLS", "db_id": "C0041427" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s3-t8", "type": "umlsterm", "text": [ "twin-twin" ], "offsets": [ [ 490, 499 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0041426" }, { "db_name": "UMLS", "db_id": "C0041427" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s3-t9", "type": "umlsterm", "text": [ "syndrome" ], "offsets": [ [ 512, 520 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s3-t10", "type": "umlsterm", "text": [ "twin" ], "offsets": [ [ 534, 538 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0041426" }, { "db_name": "UMLS", "db_id": "C0041427" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s3-t11", "type": "umlsterm", "text": [ "diaphragmatic hernia" ], "offsets": [ [ 376, 396 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019284" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s3-t12", "type": "umlsterm", "text": [ "neural tube defects" ], "offsets": [ [ 468, 487 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027794" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s3-t13", "type": "umlsterm", "text": [ "twin-twin transfusion syndrome" ], "offsets": [ [ 490, 520 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015958" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "aim" ], "offsets": [ [ 545, 548 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0108800" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "surgery" ], "offsets": [ [ 612, 619 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038894" }, { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "delivery" ], "offsets": [ [ 663, 671 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011209" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "repair" ], "offsets": [ [ 682, 688 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043240" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "malformations" ], "offsets": [ [ 721, 734 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000768" }, { "db_name": "UMLS", "db_id": "C0243070" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "fetal malformations" ], "offsets": [ [ 715, 734 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000768" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "hernia" ], "offsets": [ [ 751, 757 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019270" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "development" ], "offsets": [ [ 786, 797 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243107" }, { "db_name": "UMLS", "db_id": "C0020119" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "open" ], "offsets": [ [ 822, 826 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0266061" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "surgery" ], "offsets": [ [ 833, 840 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038894" }, { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s6-t5", "type": "umlsterm", "text": [ "surgery" ], "offsets": [ [ 874, 881 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038894" }, { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s6-t6", "type": "umlsterm", "text": [ "Diaphragmatic hernia" ], "offsets": [ [ 737, 757 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019284" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s6-t7", "type": "umlsterm", "text": [ "endoscopic surgery" ], "offsets": [ [ 863, 881 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0282493" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "work" ], "offsets": [ [ 921, 925 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043227" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s7-t2", "type": "umlsterm", "text": [ "hernia" ], "offsets": [ [ 987, 993 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019270" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s7-t3", "type": "umlsterm", "text": [ "defects" ], "offsets": [ [ 1010, 1017 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243067" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s7-t4", "type": "umlsterm", "text": [ "diaphragmatic hernia" ], "offsets": [ [ 973, 993 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019284" } ] }, { "id": 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DerGynaekologe.90320866.eng.abstr	DerGynaekologe.90320866.eng.abstr	[ { "id": "DerGynaekologe.90320866.eng.abstr-passage-0", "type": "abstract", "text": [ "Although most prenatally diagnosed anatomic malformations are best managed after birth , we can presently offer prenatal therapy to an increasing number of fetuses with simple anatomical defects that have predictably devastating developmental consequences . A condition amenable to prenatal intervention must fulfill a number of conditions . It must be severe enough to warrant the risks associated with in utero treatment and must be reliably detectable before birth . Furthermore , the pathophysiology must be reversible by fetal intervention , significantly improving the prognosis over postnatal treatment . Current indication for prenatal intervention include decompression for obstructive uropathy , temporary tracheal occlusion for congenital diaphragmatic hernia , and tumor debulking for congenital cystic adenomatoid malformation of the lung and sacrococcygeal teratoma . Prenatal repair of myelomeningocele is currently being developed but remains controversial since this is not a lethal malformation . Maternal safety remains paramount in considering fetal intervention . The main associated risks are pre-term labor and preterm premature rupture of membranes . To reduce maternal morbidity and the risk of prematurity , minimally invasive fetoscopic techniques were developed and are increasingly employed . These developments will in all probability reduce the importance of open fetal surgery in the future ." ], "offsets": [ [ 0, 1424 ] ] } ]	[ { "id": "DerGynaekologe.90320866.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "anatomic" ], "offsets": [ [ 35, 43 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220784" } ] }, { "id": "DerGynaekologe.90320866.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "malformations" ], "offsets": [ [ 44, 57 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000768" }, { "db_name": "UMLS", "db_id": "C0243070" } ] }, { "id": "DerGynaekologe.90320866.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "birth" ], "offsets": [ [ 81, 86 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005615" } ] }, { "id": "DerGynaekologe.90320866.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 121, 128 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": 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A legally valid consent from the patient and documentation of the patient information must be accessible at all times . Operations carried out by doctors in training must be supervised by a qualified specialist ; otherwise the doctor in charge is guilty of a defect in organization . Because of staff shortages it often happens that inexperienced beginners - often doctors doing their practical training - are on call very early on . In the high-risk specialty of obstetrics it is particularly important that doctors still undergoing practical training can call on an experienced colleague for help at all times . The changeover from day duty to emergency duty must be organized by the doctor in charge in such a way that the medical staff are rested and that adequate free time is guaranteed . There must be no friction when cooperation with other disciplines concerned is needed . Each sector must know its own area of responsibility . The doctor in charge is resonsible for seeing that his or her staff members are familiar with the use of the medical equipment . Uniform guidelines will make it possible for the medical director to train his/her staff and prevent systematic organizational defects ." ], "offsets": [ [ 0, 2010 ] ] } ]	[ { "id": "DerGynaekologe.90320927.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "doctor" ], "offsets": [ [ 4, 10 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031831" } ] }, { "id": "DerGynaekologe.90320927.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "charge" ], "offsets": [ [ 14, 20 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007961" } ] }, { "id": "DerGynaekologe.90320927.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 76, 84 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerGynaekologe.90320927.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "organizational" ], "offsets": [ [ 105, 119 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220885" } ] }, { "id": "DerGynaekologe.90320927.eng.abstr-s1-t5", "type": "umlsterm", "text": 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DerGynaekologe.90320933.eng.abstr	DerGynaekologe.90320933.eng.abstr	[ { "id": "DerGynaekologe.90320933.eng.abstr-passage-0", "type": "abstract", "text": [ "A differentiation is made between patient information on findings and diagnosis , patient information on avoidance of known dangers , and patient information on the risks involved in a particular intervention that has been selected . If no information is given on the risks inherent in a patient's condition and how she must proceed in order to ensure that they do not come about , this is considered to be a treatment error , and in these circumstances the intervention is then legally seen as bodily harm . Information on the risks involved in an intervention must be given in good time , which generally means on the day before the operation . An exception is made to this rule for day surgery . The patient must be informed about treatment alternatives when the method selected is not the method of choice or when there is an alternative offering equivalent chances but risks of a different kind . Such information is given to the adult patient who is capable of legal transactions . In the case of minors or of patients who are not capable of legal transactions their legal representative is responsible for receiving the information [ and making decisions ] . In the case of unconscious patients everything depends on \" presumable consent to the operation \" . If a patient later cites lacks in the information supplied to her to support a claim for compensation in a situation where it would be unwise to refuse an operation , she must elaborate plausible grounds for being in conflict over the decision even following appropriate information ." ], "offsets": [ [ 0, 1550 ] ] } ]	[ { "id": "DerGynaekologe.90320933.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 34, 41 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerGynaekologe.90320933.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "findings" ], "offsets": [ [ 57, 65 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243095" } ] }, { "id": "DerGynaekologe.90320933.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "diagnosis" ], "offsets": [ [ 70, 79 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011900" }, { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerGynaekologe.90320933.eng.abstr-s1-t4", "type": "umlsterm", 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"offsets": [ [ 528, 533 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "DerGynaekologe.90320933.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "time" ], "offsets": [ [ 584, 588 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040223" } ] }, { "id": "DerGynaekologe.90320933.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "operation" ], "offsets": [ [ 635, 644 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0543467" }, { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "DerGynaekologe.90320933.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "surgery" ], "offsets": [ [ 689, 696 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038894" }, { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "DerGynaekologe.90320933.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "day surgery" ], "offsets": [ [ 685, 696 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0282046" } ] }, { "id": "DerGynaekologe.90320933.eng.abstr-s5-t1", "type": 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It should therefore be decided at the start who is to note down its course . When endoscopic investigations are carried out it seems advisable to take short video sequences recording the salient points . Patients have a fundamental right to sight of their treatment records . In the event of a patient's death the next of kin are entitled to sight of the records , providing the patient has not left any formal request that they be kept secret ." ], "offsets": [ [ 0, 1230 ] ] } ]	[ { "id": "DerGynaekologe.90320939.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "documentation" ], "offsets": [ [ 25, 38 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012972" } ] }, { "id": "DerGynaekologe.90320939.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "treatments" ], "offsets": [ [ 42, 52 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerGynaekologe.90320939.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 349, 358 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerGynaekologe.90320939.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "obstetrics" ], "offsets": [ [ 400, 410 ] ], 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DerGynaekologe.90320944.eng.abstr	DerGynaekologe.90320944.eng.abstr	[ { "id": "DerGynaekologe.90320944.eng.abstr-passage-0", "type": "abstract", "text": [ "An overall view shows that the organization of a department of gynaecology and obstetrics is a highly complex task . Not only formal , legal positions have a role in this ; personal strengths , such as the ability to convince others by professional and personal authority and by exerting the will to manage , are also essential . Management requires the superintendent to define his or her own range of duties in collaboration with a representative or representatives of the authority responsible for the hospital . It has proved worthwhile for the responsible authority and the medical superintendent to lay down guidelines for procedures and instructions to be adopted in standard situations ( indications , informing assistant medical director , paediatrics and neonatology , examination to be carried out on admission , division of labour with midwives , etc. ) in writing , to inform the staff of these together , and to deposit the guidelines at a central point in the department , so that any member of staff can consult them without any substantial hold-up if there are any points of dispute or uncertainties ." ], "offsets": [ [ 0, 1118 ] ] } ]	[ { "id": "DerGynaekologe.90320944.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "overall" ], "offsets": [ [ 3, 10 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0282416" } ] }, { "id": "DerGynaekologe.90320944.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "organization" ], "offsets": [ [ 31, 43 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220885" }, { "db_name": "UMLS", "db_id": "C0029246" } ] }, { "id": "DerGynaekologe.90320944.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "obstetrics" ], "offsets": [ [ 79, 89 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028773" } ] }, { "id": "DerGynaekologe.90320944.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "role" ], "offsets": [ [ 158, 162 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035820" } ] }, { "id": "DerGynaekologe.90320944.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "ability" ], "offsets": [ [ 206, 213 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0085732" } ] }, { "id": "DerGynaekologe.90320944.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "collaboration" ], "offsets": [ [ 413, 426 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0282116" } ] }, { "id": "DerGynaekologe.90320944.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "hospital" ], "offsets": [ [ 505, 513 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019994" } ] }, { "id": "DerGynaekologe.90320944.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "guidelines" ], "offsets": [ [ 614, 624 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220845" }, { "db_name": "UMLS", "db_id": "C0162791" }, { "db_name": "UMLS", "db_id": "C0282423" } ] }, { "id": "DerGynaekologe.90320944.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "procedures" ], "offsets": [ [ 629, 639 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0184661" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerGynaekologe.90320944.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "instructions" ], "offsets": [ [ 644, 656 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0302828" } ] }, { "id": "DerGynaekologe.90320944.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "standard" ], "offsets": [ [ 674, 682 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038137" }, { "db_name": "UMLS", "db_id": "C0175675" } ] }, { "id": "DerGynaekologe.90320944.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "neonatology" ], "offsets": [ [ 765, 776 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027621" } ] }, { "id": "DerGynaekologe.90320944.eng.abstr-s4-t6", "type": "umlsterm", "text": [ "labour" ], "offsets": [ [ 836, 842 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022864" } ] }, { "id": "DerGynaekologe.90320944.eng.abstr-s4-t7", "type": "umlsterm", "text": [ "midwives" ], "offsets": [ [ 848, 856 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026083" } ] }, { "id": "DerGynaekologe.90320944.eng.abstr-s4-t8", "type": "umlsterm", "text": [ "guidelines" ], "offsets": [ [ 938, 948 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220845" }, { "db_name": "UMLS", "db_id": "C0162791" }, { "db_name": "UMLS", "db_id": "C0282423" } ] }, { "id": "DerGynaekologe.90320944.eng.abstr-s4-t9", "type": "umlsterm", "text": [ "uncertainties" ], "offsets": [ [ 1103, 1116 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087130" } ] }, { "id": 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"DerGynaekologe.90320944.eng.abstr-s4-t1", "normalized": [] }, { "id": "DerGynaekologe.90320944.eng.abstr-s4-r15-t7.1-t4.1", "type": "uses", "arg1_id": "DerGynaekologe.90320944.eng.abstr-s4-t7", "arg2_id": "DerGynaekologe.90320944.eng.abstr-s4-t4", "normalized": [] }, { "id": "DerGynaekologe.90320944.eng.abstr-s4-r16-t1.3-t9.1", "type": "isa", "arg1_id": "DerGynaekologe.90320944.eng.abstr-s4-t1", "arg2_id": "DerGynaekologe.90320944.eng.abstr-s4-t9", "normalized": [] }, { "id": "DerGynaekologe.90320944.eng.abstr-s4-r17-t4.2-t9.1", "type": "isa", "arg1_id": "DerGynaekologe.90320944.eng.abstr-s4-t4", "arg2_id": "DerGynaekologe.90320944.eng.abstr-s4-t9", "normalized": [] }, { "id": "DerGynaekologe.90320944.eng.abstr-s4-r18-t1.3-t6.1", "type": "measurement_of", "arg1_id": "DerGynaekologe.90320944.eng.abstr-s4-t1", "arg2_id": "DerGynaekologe.90320944.eng.abstr-s4-t6", "normalized": [] }, { "id": "DerGynaekologe.90320944.eng.abstr-s4-r19-t8.3-t1.1", "type": "uses", "arg1_id": 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DerGynaekologe.90320953.eng.abstr	DerGynaekologe.90320953.eng.abstr	[ { "id": "DerGynaekologe.90320953.eng.abstr-passage-0", "type": "abstract", "text": [ "Malpractice still involves the highest risk of being found liable for damages in the obstetrics and gynaecology sector . Awareness of faults that are particularly frequent and involve liability for particularly high damages can help practitioners to avoid them . Following the definition of ' malpractice ' , the role of directives and standards is briefly discussed . Then the forms of malpractice are presented : errors in diagnosis , faulty therapy , culpable failure to provide adequate information on patients transferred to the care of others , and provision of poor advice ; typical faults are explained with reference to clinical examples and/or case reports . Particular attention is paid to grave malpractice with consequent reversal of the burden of proof , which is also illustrated by reference to examples of cases . It is shown that the highest risk of liability for damages after malpractice , with extremely high sums awarded in some cases , applies in the case of obstetrics , primarily as a result of not performing cesarian sections or of performing them too late . Problems of causation are then discussed , particularly in view of the changed legal practice , in cases of cerebral damage suffered by children , of regularly commissioning expert assessments from paediatric neurologists and neonatologists , which can incriminate or exonerate the obstetrician . Attention is drawn to the fact - which is still too tittle known - that even the nonascertainment of urgently required findings can lead to reversal of the burden of proof in the same way as an instance of \" grave malpractice \" ." ], "offsets": [ [ 0, 1612 ] ] } ]	[ { "id": "DerGynaekologe.90320953.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Malpractice" ], "offsets": [ [ 0, 11 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024650" } ] }, { "id": "DerGynaekologe.90320953.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "risk" ], "offsets": [ [ 39, 43 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "DerGynaekologe.90320953.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "obstetrics" ], "offsets": [ [ 85, 95 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028773" } ] }, { "id": "DerGynaekologe.90320953.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "risk of" ], "offsets": [ [ 39, 46 ] ], "normalized": [ { "db_name": "UMLS", "db_id": 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DerHautarzt.00510003.eng.abstr	DerHautarzt.00510003.eng.abstr	[ { "id": "DerHautarzt.00510003.eng.abstr-passage-0", "type": "abstract", "text": [ "In Germany , if the dermatologist has definite proof that a patient's skin disorder is severe or chronic , work-related and requiring a change in occupation , then he or she must issue a Berufskrankheitenanzeige ( loosely translated as occupational disease notification ) . The patient's consent is not required for this mandatory form , which has to be submitted even if the patient is opposed . On the other hand , if there is only a possible connection between the occupation and the skin disorder , or if the skin disease is neither severe nor chronic nor threatening pursuit of the occupation , then the dermatologist needs only write a Hautarztbericht ( dermatologist's report ) . The patient's permission is required for this less formal document ." ], "offsets": [ [ 0, 755 ] ] } ]	[ { "id": "DerHautarzt.00510003.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Germany" ], "offsets": [ [ 3, 10 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017480" } ] }, { "id": "DerHautarzt.00510003.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "skin" ], "offsets": [ [ 70, 74 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] }, { "id": "DerHautarzt.00510003.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "disorder" ], "offsets": [ [ 75, 83 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510003.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "occupation" ], "offsets": [ [ 146, 156 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028811" } ] }, { "id": "DerHautarzt.00510003.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 249, 256 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510003.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "skin disorder" ], "offsets": [ [ 70, 83 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037274" } ] }, { "id": "DerHautarzt.00510003.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "occupational disease" ], "offsets": [ [ 236, 256 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028797" } ] }, { "id": "DerHautarzt.00510003.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "disease notification" ], "offsets": [ [ 249, 269 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242783" } ] }, { "id": "DerHautarzt.00510003.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "form" ], "offsets": [ [ 331, 335 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376315" } ] }, { "id": "DerHautarzt.00510003.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 376, 383 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510003.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "hand" ], "offsets": [ [ 410, 414 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018563" } ] }, { "id": "DerHautarzt.00510003.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "occupation" ], "offsets": [ [ 468, 478 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028811" } ] }, { "id": "DerHautarzt.00510003.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "skin" ], "offsets": [ [ 487, 491 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] }, { "id": "DerHautarzt.00510003.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "disorder" ], "offsets": [ [ 492, 500 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510003.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "skin" ], "offsets": [ [ 513, 517 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] }, { "id": "DerHautarzt.00510003.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 518, 525 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510003.eng.abstr-s3-t7", "type": "umlsterm", "text": [ "occupation" ], "offsets": [ [ 587, 597 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028811" } ] }, { "id": "DerHautarzt.00510003.eng.abstr-s3-t8", "type": "umlsterm", "text": [ "dermatologist's" ], "offsets": [ [ 660, 675 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0605770" } ] }, { "id": "DerHautarzt.00510003.eng.abstr-s3-t9", "type": "umlsterm", "text": [ "skin disorder" ], "offsets": [ [ 487, 500 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037274" } ] }, { "id": "DerHautarzt.00510003.eng.abstr-s3-t10", "type": "umlsterm", "text": [ "skin disease" ], "offsets": [ [ 513, 525 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037274" } ] } ]	[]	[]	[ { "id": "DerHautarzt.00510003.eng.abstr-s1-r1-t1.1-t4.1", "type": "issue_in", "arg1_id": "DerHautarzt.00510003.eng.abstr-s3-t1", "arg2_id": 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DerHautarzt.00510014.eng.abstr	DerHautarzt.00510014.eng.abstr	[ { "id": "DerHautarzt.00510014.eng.abstr-passage-0", "type": "abstract", "text": [ "Background and objective : A complicated course of erysipelas is not uncommon . Bullous , haemorrhagic , necrotic and purulent lesions may be encountered . Today no reliable data exist as to which constitutional factors renders a patient at risk for developing complicated erysipelas though several risk factors , particularly diabetes mellitus , are often suggested . Based on the analysis of patients with erysipelas at the Department of Dermatology in Graz , factors determining the risk for complicated erysipelas should be identified . Patients/Methods : In a retrospective case-control study clinical data sheets of 766 in- patients treated at the department were evaluated with respect to the course of the erysipelas and with respect to potential risk factors . Results : General risk factors for local complications were location at the lower extremities , pre-existing hepatic or renal disease , hyperuricaemia , and diabetes mellitus . Hepatic and renal disease and - to a lesser extent - diabetes particularly predisposed for bullous and haemorrhagic lesions , while vascular occlusive disease enhanced the risk for ne- crotic lesions . Conclusions : Location and hepatic and renal disease are the most important risk factors , while diabetes is probably of less significance than previously suggested ." ], "offsets": [ [ 0, 1315 ] ] } ]	[ { "id": "DerHautarzt.00510014.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "objective" ], "offsets": [ [ 15, 24 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018017" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "erysipelas" ], "offsets": [ [ 51, 61 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014733" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 230, 237 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "risk" ], "offsets": [ [ 241, 245 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "erysipelas" ], "offsets": [ [ 273, 283 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014733" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "risk" ], "offsets": [ [ 299, 303 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "diabetes" ], "offsets": [ [ 327, 335 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011847" }, { "db_name": "UMLS", "db_id": "C0011849" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "risk factors" ], "offsets": [ [ 299, 311 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035648" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s3-t7", "type": "umlsterm", "text": [ "diabetes mellitus" ], "offsets": [ [ 327, 344 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011849" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "analysis" ], "offsets": [ [ 382, 390 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002778" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 394, 402 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "erysipelas" ], "offsets": [ [ 408, 418 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014733" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "Dermatology" ], "offsets": [ [ 440, 451 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011627" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "risk" ], "offsets": [ [ 486, 490 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s4-t6", "type": "umlsterm", "text": [ "erysipelas" ], "offsets": [ [ 507, 517 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014733" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "retrospective" ], "offsets": [ [ 565, 578 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035363" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 630, 638 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "erysipelas" ], "offsets": [ [ 714, 724 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014733" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "risk" ], "offsets": [ [ 755, 759 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s5-t5", "type": "umlsterm", "text": [ "case-control study" ], "offsets": [ [ 579, 597 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007328" } ] }, { "id": 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DerHautarzt.00510025.eng.abstr	DerHautarzt.00510025.eng.abstr	[ { "id": "DerHautarzt.00510025.eng.abstr-passage-0", "type": "abstract", "text": [ "Background and Objective : Pemphigoid gestationis ( PG ) is a rare pregnancy-associated autoimmune bullous disease characterized by autoantibodies to the 180 kD bullous pemphigoid antigen ( BP180). The clinical spectrum of PG is polymorphic and for diagnostic purposes , a skin biopsy is usually taken demonstrating the deposition of autoantibodies ." ], "offsets": [ [ 0, 350 ] ] } ]	[ { "id": "DerHautarzt.00510025.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Objective" ], "offsets": [ [ 15, 24 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018017" } ] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "Pemphigoid" ], "offsets": [ [ 27, 37 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030805" } ] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "pregnancy-associated" ], "offsets": [ [ 67, 87 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 107, 114 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "autoantibodies" ], "offsets": [ [ 132, 146 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004358" } ] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "pemphigoid" ], "offsets": [ [ 169, 179 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030805" } ] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "antigen" ], "offsets": [ [ 180, 187 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003320" } ] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "diagnostic" ], "offsets": [ [ 249, 259 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-t9", "type": "umlsterm", "text": [ "skin" ], "offsets": [ [ 273, 277 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-t10", "type": "umlsterm", "text": [ "biopsy" ], "offsets": [ [ 278, 284 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220797" }, { "db_name": "UMLS", "db_id": "C0005558" } ] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-t11", "type": "umlsterm", "text": [ "autoantibodies" ], "offsets": [ [ 334, 348 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004358" } ] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-t12", "type": "umlsterm", "text": [ "bullous pemphigoid" ], "offsets": [ [ 161, 179 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030805" } ] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-t13", "type": "umlsterm", "text": [ "bullous pemphigoid antigen" ], "offsets": [ [ 161, 187 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0054218" } ] } ]	[]	[]	[ { "id": "DerHautarzt.00510025.eng.abstr-s1-r1-t7.1-t4.1", "type": "indicates", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t7", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t4", "normalized": [] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-r2-t3.1-t7.1", "type": "produces", "arg1_id": 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DerHautarzt.00510031.eng.abstr	DerHautarzt.00510031.eng.abstr	[ { "id": "DerHautarzt.00510031.eng.abstr-passage-0", "type": "abstract", "text": [ "Hyperkeratosis lenticularis perstans ( Flegel's disease ) is a rare but clinically and histologically highly characteristic genodermatosis . We report on new immunohistochemical and ultrastructural findings suggesting a complex disorder of epidermal differentiation . In this context , a good response to calcipotriol , a synthetic vitamin D3 derivative is of particular interest ." ], "offsets": [ [ 0, 381 ] ] } ]	[ { "id": "DerHautarzt.00510031.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Hyperkeratosis" ], "offsets": [ [ 0, 14 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0751995" } ] }, { "id": "DerHautarzt.00510031.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 48, 55 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510031.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "findings" ], "offsets": [ [ 198, 206 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243095" } ] }, { "id": "DerHautarzt.00510031.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "disorder" ], "offsets": [ [ 228, 236 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510031.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "calcipotriol" ], "offsets": [ [ 305, 317 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0065767" } ] }, { "id": "DerHautarzt.00510031.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "vitamin" ], "offsets": [ [ 332, 339 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042890" } ] }, { "id": "DerHautarzt.00510031.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "derivative" ], "offsets": [ [ 343, 353 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243072" } ] }, { "id": "DerHautarzt.00510031.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "vitamin D3" ], "offsets": [ [ 332, 342 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008318" } ] } ]	[]	[]	[ { "id": "DerHautarzt.00510031.eng.abstr-s3-r1-t3.1-t1.1", "type": "interacts_with", "arg1_id": "DerHautarzt.00510031.eng.abstr-s3-t3", "arg2_id": "DerHautarzt.00510031.eng.abstr-s3-t1", "normalized": [] }, { "id": "DerHautarzt.00510031.eng.abstr-s3-r2-t1.1-t3.1", "type": "interacts_with", "arg1_id": "DerHautarzt.00510031.eng.abstr-s3-t1", "arg2_id": "DerHautarzt.00510031.eng.abstr-s3-t3", "normalized": [] } ]
DerHautarzt.00510036.eng.abstr	DerHautarzt.00510036.eng.abstr	[ { "id": "DerHautarzt.00510036.eng.abstr-passage-0", "type": "abstract", "text": [ "Calciphylaxis is a rare but potentially life-threatening complication in chronic renal failure . It is characterized by ischemic tissue necrosis primarily of the skin . The typical histopathologic finding is microvascular calcification with endovascular fibrosis . Patients typically present with violaceous , mottled and painful lesions which tend to progress to non-healing ulcers and necrosis . Most frequently the lower extremities are involved in a symmetric fashion but the trunk may also be affected . Sepsis from superinfection of the lesions accounts for the high mortality of this disease which is of importance for dermatologists and nephrologists alike . 61-year-old female patient developed lesions of calciphylaxis on both calves two years after beginning hemodialysis to treat renal failure due to diabetic glomerulosclerosis . We discuss aspects of the pathogenesis of calciphylaxis , as well as diagnosis , treatment and means of preventions , and review the current literature ." ], "offsets": [ [ 0, 996 ] ] } ]	[ { "id": "DerHautarzt.00510036.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Calciphylaxis" ], "offsets": [ [ 0, 13 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006666" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "complication" ], "offsets": [ [ 57, 69 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009566" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "renal failure" ], "offsets": [ [ 81, 94 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035078" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "chronic renal failure" ], "offsets": [ [ 73, 94 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022661" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "ischemic" ], "offsets": [ [ 120, 128 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022116" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "tissue" ], "offsets": [ [ 129, 135 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040300" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "necrosis" ], "offsets": [ [ 136, 144 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027540" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "skin" ], "offsets": [ [ 162, 166 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "finding" ], "offsets": [ [ 197, 204 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243095" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "calcification" ], "offsets": [ [ 222, 235 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006660" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "fibrosis" ], "offsets": [ [ 254, 262 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016059" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "Patients" ], "offsets": [ [ 265, 273 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "ulcers" ], "offsets": [ [ 376, 382 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0041582" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "necrosis" ], "offsets": [ [ 387, 395 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027540" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "extremities" ], "offsets": [ [ 424, 435 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015385" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "lower extremities" ], "offsets": [ [ 418, 435 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023216" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "Sepsis" ], "offsets": [ [ 509, 515 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243026" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "superinfection" ], "offsets": [ [ 521, 535 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038826" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "mortality" ], "offsets": [ [ 573, 582 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026566" }, { "db_name": "UMLS", "db_id": "C0026565" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 591, 598 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "female" ], "offsets": [ [ 679, 685 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086287" }, { "db_name": "UMLS", "db_id": "C0015780" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s7-t2", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 686, 693 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s7-t3", "type": "umlsterm", "text": [ "calciphylaxis" ], "offsets": [ [ 715, 728 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006666" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s7-t4", "type": "umlsterm", "text": [ "hemodialysis" ], "offsets": [ [ 770, 782 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019004" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s7-t5", "type": "umlsterm", "text": [ "renal failure" ], "offsets": [ [ 792, 805 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035078" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s7-t6", "type": "umlsterm", "text": [ "diabetic glomerulosclerosis" ], "offsets": [ [ 813, 840 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017667" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s8-t1", "type": "umlsterm", "text": [ "pathogenesis" ], "offsets": [ [ 869, 881 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0543483" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s8-t2", "type": "umlsterm", "text": [ "calciphylaxis" ], "offsets": [ [ 885, 898 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006666" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s8-t3", "type": "umlsterm", "text": [ "diagnosis" ], "offsets": [ [ 912, 921 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011900" }, { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s8-t4", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 924, 933 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s8-t5", "type": "umlsterm", "text": [ "literature" ], "offsets": [ [ 984, 994 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023866" } ] } ]	[]	[]	[ { "id": "DerHautarzt.00510036.eng.abstr-s1-r1-t2.1-t4.1", "type": "degree_of", "arg1_id": "DerHautarzt.00510036.eng.abstr-s8-t2", "arg2_id": "DerHautarzt.00510036.eng.abstr-s8-t4", "normalized": [] }, { "id": "DerHautarzt.00510036.eng.abstr-s1-r2-t2.1-t1.1", "type": "degree_of", "arg1_id": "DerHautarzt.00510036.eng.abstr-s8-t2", "arg2_id": "DerHautarzt.00510036.eng.abstr-s8-t1", "normalized": [] }, { "id": "DerHautarzt.00510036.eng.abstr-s1-r3-t4.1-t2.1", "type": "degree_of", "arg1_id": "DerHautarzt.00510036.eng.abstr-s8-t4", "arg2_id": "DerHautarzt.00510036.eng.abstr-s8-t2", "normalized": [] }, { "id": "DerHautarzt.00510036.eng.abstr-s1-r4-t1.1-t2.1", "type": "degree_of", "arg1_id": "DerHautarzt.00510036.eng.abstr-s8-t1", "arg2_id": 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DerHautarzt.00510041.eng.abstr	DerHautarzt.00510041.eng.abstr	[ { "id": "DerHautarzt.00510041.eng.abstr-passage-0", "type": "abstract", "text": [ "Cutaneous metastases from a leiomyosarcoma of the testicular tunica albuginea are very rare . Primary leiomyosarcomas in this site are uncommen and furthermore cutaneous metastases develop only in 1,4% of all malignant tumors of the internal organs [ 10 ] . A 71 year old patient with such a sarcoma underwent primary excision . Nine months later multiple , firm , nodules were identified as cutaneous metastases . Further staging revealed already extensive , diffuse pulmonary and bony metastases without contiguous or regional lymph node involvement ." ], "offsets": [ [ 0, 553 ] ] } ]	[ { "id": "DerHautarzt.00510041.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "metastases" ], "offsets": [ [ 10, 20 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027627" } ] }, { "id": "DerHautarzt.00510041.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "leiomyosarcoma" ], "offsets": [ [ 28, 42 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023269" } ] }, { "id": "DerHautarzt.00510041.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "leiomyosarcomas" ], "offsets": [ [ 102, 117 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023269" } ] }, { "id": "DerHautarzt.00510041.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "metastases" ], "offsets": [ [ 170, 180 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027627" } ] }, { "id": "DerHautarzt.00510041.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "malignant" ], "offsets": [ [ 209, 218 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006826" } ] }, { "id": "DerHautarzt.00510041.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "tumors" ], "offsets": [ [ 219, 225 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerHautarzt.00510041.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "malignant tumors" ], "offsets": [ [ 209, 225 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006826" } ] }, { "id": "DerHautarzt.00510041.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "old" ], "offsets": [ [ 268, 271 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0331059" } ] }, { "id": "DerHautarzt.00510041.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 272, 279 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510041.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "sarcoma" ], "offsets": [ [ 292, 299 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036210" } ] }, { "id": "DerHautarzt.00510041.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "metastases" ], "offsets": [ [ 402, 412 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027627" } ] }, { "id": "DerHautarzt.00510041.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "metastases" ], "offsets": [ [ 487, 497 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027627" } ] }, { "id": "DerHautarzt.00510041.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "lymph" ], "offsets": [ [ 529, 534 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024202" } ] }, { "id": "DerHautarzt.00510041.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "lymph node" ], "offsets": [ [ 529, 539 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024204" } ] } ]	[]	[]	[ { "id": "DerHautarzt.00510041.eng.abstr-s3-r1-t3.1-t1.1", "type": "affects", "arg1_id": "DerHautarzt.00510041.eng.abstr-s5-t3", "arg2_id": "DerHautarzt.00510041.eng.abstr-s5-t1", "normalized": [] }, { "id": "DerHautarzt.00510041.eng.abstr-s3-r2-t3.1-t1.1", "type": "occurs_in", "arg1_id": "DerHautarzt.00510041.eng.abstr-s5-t3", "arg2_id": "DerHautarzt.00510041.eng.abstr-s5-t1", "normalized": [] }, { "id": "DerHautarzt.00510041.eng.abstr-s5-r1-t3.1-t2.1", "type": "connected_to", "arg1_id": "DerHautarzt.00510041.eng.abstr-s5-t3", "arg2_id": "DerHautarzt.00510041.eng.abstr-s5-t2", "normalized": [] }, { "id": "DerHautarzt.00510041.eng.abstr-s5-r2-t2.1-t1.1", "type": "causes", "arg1_id": "DerHautarzt.00510041.eng.abstr-s5-t2", "arg2_id": "DerHautarzt.00510041.eng.abstr-s5-t1", "normalized": [] }, { "id": "DerHautarzt.00510041.eng.abstr-s5-r3-t2.1-t3.1", "type": "connected_to", "arg1_id": "DerHautarzt.00510041.eng.abstr-s5-t2", "arg2_id": "DerHautarzt.00510041.eng.abstr-s5-t3", "normalized": [] }, { "id": "DerHautarzt.00510041.eng.abstr-s5-r4-t3.1-t1.1", "type": "location_of", "arg1_id": "DerHautarzt.00510041.eng.abstr-s5-t3", "arg2_id": "DerHautarzt.00510041.eng.abstr-s5-t1", "normalized": [] }, { "id": "DerHautarzt.00510041.eng.abstr-s5-r5-t1.1-t2.1", "type": "produces", "arg1_id": "DerHautarzt.00510041.eng.abstr-s5-t1", "arg2_id": "DerHautarzt.00510041.eng.abstr-s5-t2", "normalized": [] } ]
DerHautarzt.00510059.eng.abstr	DerHautarzt.00510059.eng.abstr	[ { "id": "DerHautarzt.00510059.eng.abstr-passage-0", "type": "abstract", "text": [ "Persistent cellular microchimerism might play a role in the pathogenesis of systemic sclerosis ( SSc ) . Microchimerism results from the traffic of fetal cells through the placenta during pregnancy into the maternal circulation and their survival due to HLA class II compatibility . In female SSc patients the presence of fetal CD3-positive T-cells in the maternal circulation and of fetal cells in the affected skin tissue has been identified through y chromosome specific DNA sequences . The persistent microchimerism might cause SSc in certain patients by initiating a fetal anti-maternal Graft-versus-host-like response ." ], "offsets": [ [ 0, 625 ] ] } ]	[ { "id": "DerHautarzt.00510059.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "role" ], "offsets": [ [ 48, 52 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035820" } ] }, { "id": "DerHautarzt.00510059.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "pathogenesis" ], "offsets": [ [ 60, 72 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0543483" } ] }, { "id": "DerHautarzt.00510059.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "sclerosis" ], "offsets": [ [ 85, 94 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036429" } ] }, { "id": "DerHautarzt.00510059.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "systemic sclerosis" ], "offsets": [ [ 76, 94 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036421" } ] }, { "id": "DerHautarzt.00510059.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "cells" ], "offsets": [ [ 154, 159 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "DerHautarzt.00510059.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "placenta" ], "offsets": [ [ 172, 180 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032043" } ] }, { "id": "DerHautarzt.00510059.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "pregnancy" ], "offsets": [ [ 188, 197 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "DerHautarzt.00510059.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "circulation" ], "offsets": [ [ 216, 227 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005775" } ] }, { "id": "DerHautarzt.00510059.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "survival" ], "offsets": [ [ 238, 246 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220921" }, { "db_name": "UMLS", "db_id": "C0038952" } ] }, { "id": "DerHautarzt.00510059.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "HLA" ], "offsets": [ [ 254, 257 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019721" } ] }, { "id": "DerHautarzt.00510059.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "female" ], "offsets": [ [ 286, 292 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086287" }, { "db_name": "UMLS", "db_id": "C0015780" } ] }, { "id": "DerHautarzt.00510059.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 297, 305 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510059.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "circulation" ], "offsets": [ [ 365, 376 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005775" } ] }, { "id": "DerHautarzt.00510059.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "cells" ], "offsets": [ [ 390, 395 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "DerHautarzt.00510059.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "skin" ], "offsets": [ [ 412, 416 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] }, { "id": "DerHautarzt.00510059.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "tissue" ], "offsets": [ [ 417, 423 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040300" } ] }, { "id": "DerHautarzt.00510059.eng.abstr-s3-t7", "type": "umlsterm", "text": [ "chromosome" ], "offsets": [ [ 454, 464 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008633" } ] }, { "id": "DerHautarzt.00510059.eng.abstr-s3-t8", "type": "umlsterm", "text": [ "DNA" ], "offsets": [ [ 474, 477 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012854" } ] }, { "id": "DerHautarzt.00510059.eng.abstr-s3-t9", "type": "umlsterm", "text": [ "y chromosome" ], "offsets": [ [ 452, 464 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043381" } ] }, { "id": "DerHautarzt.00510059.eng.abstr-s3-t10", "type": "umlsterm", "text": [ "DNA sequences" ], "offsets": [ [ 474, 487 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162326" } ] }, { "id": "DerHautarzt.00510059.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 547, 555 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510059.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "anti-maternal" ], "offsets": [ [ 578, 591 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003209" }, { "db_name": "UMLS", "db_id": "C0003204" } ] } ]	[]	[]	[ { "id": "DerHautarzt.00510059.eng.abstr-s1-r1-t4.1-t2.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510059.eng.abstr-s3-t4", "arg2_id": "DerHautarzt.00510059.eng.abstr-s4-t2", "normalized": [] }, { "id": "DerHautarzt.00510059.eng.abstr-s1-r2-t2.1-t1.1", "type": "result_of", "arg1_id": "DerHautarzt.00510059.eng.abstr-s4-t2", "arg2_id": "DerHautarzt.00510059.eng.abstr-s4-t1", "normalized": [] }, { "id": "DerHautarzt.00510059.eng.abstr-s1-r3-t2.1-t4.1", "type": "degree_of", "arg1_id": "DerHautarzt.00510059.eng.abstr-s4-t2", "arg2_id": 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"arg1_id": "DerHautarzt.00510059.eng.abstr-s3-t4", "arg2_id": "DerHautarzt.00510059.eng.abstr-s3-t6", "normalized": [] }, { "id": "DerHautarzt.00510059.eng.abstr-s2-r13-t1.1-t4.1", "type": "location_of", "arg1_id": "DerHautarzt.00510059.eng.abstr-s4-t1", "arg2_id": "DerHautarzt.00510059.eng.abstr-s3-t4", "normalized": [] }, { "id": "DerHautarzt.00510059.eng.abstr-s2-r14-t2.1-t1.1", "type": "developmental_form_of", "arg1_id": "DerHautarzt.00510059.eng.abstr-s4-t2", "arg2_id": "DerHautarzt.00510059.eng.abstr-s4-t1", "normalized": [] }, { "id": "DerHautarzt.00510059.eng.abstr-s3-r1-t6.1-t4.1", "type": "surrounds", "arg1_id": "DerHautarzt.00510059.eng.abstr-s3-t6", "arg2_id": "DerHautarzt.00510059.eng.abstr-s3-t4", "normalized": [] }, { "id": "DerHautarzt.00510059.eng.abstr-s3-r2-t10.1-t8.1", "type": "property_of", "arg1_id": "DerHautarzt.00510059.eng.abstr-s3-t10", "arg2_id": "DerHautarzt.00510059.eng.abstr-s3-t8", "normalized": [] }, { "id": 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[] }, { "id": "DerHautarzt.00510059.eng.abstr-s3-r42-t5.1-t8.1", "type": "produces", "arg1_id": "DerHautarzt.00510059.eng.abstr-s3-t5", "arg2_id": "DerHautarzt.00510059.eng.abstr-s3-t8", "normalized": [] } ]
DerHautarzt.00510063.eng.abstr	DerHautarzt.00510063.eng.abstr	[ { "id": "DerHautarzt.00510063.eng.abstr-passage-0", "type": "abstract", "text": [ "Mycophenolate mofetil represents a new immunosuppressive drug . Several case reports have shown that mycophenolate mofetil has a good therapeutic effect in patients with psoriasis and autoimmune dermatoses . Mycophenolate mofetil is a morpholine ester of mycophenolic acid which was shown in the 1970s to be effective in patients with severe psoriasis . Mycophenolate mofetil has an increased bioavailability as compared to mycophenolic acid and thereby an improved therapeutic window . Currently , mycophenolate mofetil is indiated for the prevention of organ rejection in transplant patients . The mode of action and the pharmacology of mycophenolate mofetil are reviewed and the current clinical experience with this immunosuppressive drug for dermatological disorders is summarized ." ], "offsets": [ [ 0, 787 ] ] } ]	[ { "id": "DerHautarzt.00510063.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "immunosuppressive" ], "offsets": [ [ 39, 56 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021081" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "drug" ], "offsets": [ [ 57, 61 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013227" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "Mycophenolate mofetil" ], "offsets": [ [ 0, 21 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0209368" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "immunosuppressive drug" ], "offsets": [ [ 39, 61 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021081" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "therapeutic" ], "offsets": [ [ 134, 145 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 156, 164 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "psoriasis" ], "offsets": [ [ 170, 179 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033860" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "dermatoses" ], "offsets": [ [ 195, 205 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037274" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "case reports" ], "offsets": [ [ 72, 84 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007320" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "mycophenolate mofetil" ], "offsets": [ [ 101, 122 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0209368" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "morpholine" ], "offsets": [ [ 235, 245 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026560" }, { "db_name": "UMLS", "db_id": "C0026561" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "ester" ], "offsets": [ [ 246, 251 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014898" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "acid" ], "offsets": [ [ 268, 272 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001128" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 321, 329 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "psoriasis" ], "offsets": [ [ 342, 351 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033860" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "Mycophenolate mofetil" ], "offsets": [ [ 208, 229 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0209368" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s3-t7", "type": "umlsterm", "text": [ "mycophenolic acid" ], "offsets": [ [ 255, 272 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026933" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "bioavailability" ], "offsets": [ [ 393, 408 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005508" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "acid" ], "offsets": [ [ 437, 441 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001128" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "therapeutic" ], "offsets": [ [ 466, 477 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "Mycophenolate mofetil" ], "offsets": [ [ 354, 375 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0209368" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "mycophenolic acid" ], "offsets": [ [ 424, 441 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026933" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "prevention" ], "offsets": [ [ 541, 551 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0687732" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "rejection" ], "offsets": [ [ 561, 570 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035015" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "transplant" ], "offsets": [ [ 574, 584 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0332835" }, { "db_name": "UMLS", "db_id": "C0040733" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 585, 593 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s5-t5", "type": "umlsterm", "text": [ "mycophenolate mofetil" ], "offsets": [ [ 499, 520 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0209368" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "pharmacology" ], "offsets": [ [ 623, 635 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0205464" }, { "db_name": "UMLS", "db_id": "C0031330" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "immunosuppressive" ], "offsets": [ [ 720, 737 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021081" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "drug" ], "offsets": [ [ 738, 742 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013227" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "disorders" ], "offsets": [ [ 762, 771 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s6-t5", "type": "umlsterm", "text": [ "mycophenolate mofetil" ], "offsets": [ [ 639, 660 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0209368" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s6-t6", "type": "umlsterm", "text": [ "immunosuppressive drug" ], "offsets": [ [ 720, 742 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021081" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s6-t7", "type": "umlsterm", "text": [ "dermatological disorders" ], "offsets": [ [ 747, 771 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037274" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s6-t8", "type": "umlsterm", "text": [ "mode of action" ], "offsets": [ [ 600, 614 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0205464" } ] } ]	[]	[]	[ { "id": "DerHautarzt.00510063.eng.abstr-s1-r1-t3.1-t1.1", "type": "interacts_with", "arg1_id": "DerHautarzt.00510063.eng.abstr-s6-t3", "arg2_id": "DerHautarzt.00510063.eng.abstr-s6-t1", "normalized": [] }, { "id": "DerHautarzt.00510063.eng.abstr-s1-r2-t3.1-t2.1", "type": "interacts_with", "arg1_id": "DerHautarzt.00510063.eng.abstr-s6-t3", "arg2_id": "DerHautarzt.00510063.eng.abstr-s6-t2", "normalized": [] }, { "id": "DerHautarzt.00510063.eng.abstr-s2-r1-t2.1-t1.1", "type": "performs", "arg1_id": "DerHautarzt.00510063.eng.abstr-s6-t2", "arg2_id": "DerHautarzt.00510063.eng.abstr-s6-t1", "normalized": [] }, { "id": "DerHautarzt.00510063.eng.abstr-s2-r2-t1.1-t2.1", "type": "affects", "arg1_id": "DerHautarzt.00510063.eng.abstr-s6-t1", "arg2_id": "DerHautarzt.00510063.eng.abstr-s6-t2", "normalized": [] }, { "id": "DerHautarzt.00510063.eng.abstr-s2-r3-t6.1-t3.1", "type": "diagnoses", "arg1_id": "DerHautarzt.00510063.eng.abstr-s6-t6", "arg2_id": 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"arg2_id": "DerHautarzt.00510063.eng.abstr-s6-t5", "normalized": [] }, { "id": "DerHautarzt.00510063.eng.abstr-s2-r9-t4.1-t2.1", "type": "occurs_in", "arg1_id": "DerHautarzt.00510063.eng.abstr-s6-t4", "arg2_id": "DerHautarzt.00510063.eng.abstr-s6-t2", "normalized": [] }, { "id": "DerHautarzt.00510063.eng.abstr-s2-r10-t6.1-t4.1", "type": "diagnoses", "arg1_id": "DerHautarzt.00510063.eng.abstr-s6-t6", "arg2_id": "DerHautarzt.00510063.eng.abstr-s6-t4", "normalized": [] }, { "id": "DerHautarzt.00510063.eng.abstr-s2-r11-t1.1-t4.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510063.eng.abstr-s6-t1", "arg2_id": "DerHautarzt.00510063.eng.abstr-s6-t4", "normalized": [] }, { "id": "DerHautarzt.00510063.eng.abstr-s2-r12-t1.1-t6.1", "type": "uses", "arg1_id": "DerHautarzt.00510063.eng.abstr-s6-t1", "arg2_id": "DerHautarzt.00510063.eng.abstr-s6-t6", "normalized": [] }, { "id": "DerHautarzt.00510063.eng.abstr-s2-r13-t6.1-t4.1", "type": "affects", "arg1_id": "DerHautarzt.00510063.eng.abstr-s6-t6", "arg2_id": "DerHautarzt.00510063.eng.abstr-s6-t4", "normalized": [] }, { "id": "DerHautarzt.00510063.eng.abstr-s2-r14-t1.1-t3.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510063.eng.abstr-s6-t1", "arg2_id": "DerHautarzt.00510063.eng.abstr-s6-t3", "normalized": [] }, { "id": "DerHautarzt.00510063.eng.abstr-s3-r1-t6.1-t3.1", "type": "interacts_with", "arg1_id": "DerHautarzt.00510063.eng.abstr-s6-t6", "arg2_id": "DerHautarzt.00510063.eng.abstr-s6-t3", "normalized": [] }, { "id": "DerHautarzt.00510063.eng.abstr-s3-r2-t6.1-t5.1", "type": "affects", "arg1_id": "DerHautarzt.00510063.eng.abstr-s6-t6", "arg2_id": "DerHautarzt.00510063.eng.abstr-s6-t5", "normalized": [] }, { "id": "DerHautarzt.00510063.eng.abstr-s3-r3-t6.1-t5.1", "type": "diagnoses", "arg1_id": "DerHautarzt.00510063.eng.abstr-s6-t6", "arg2_id": "DerHautarzt.00510063.eng.abstr-s6-t5", "normalized": [] }, { "id": "DerHautarzt.00510063.eng.abstr-s3-r4-t6.1-t2.1", "type": "interacts_with", "arg1_id": "DerHautarzt.00510063.eng.abstr-s6-t6", "arg2_id": "DerHautarzt.00510063.eng.abstr-s6-t2", "normalized": [] }, { "id": "DerHautarzt.00510063.eng.abstr-s3-r5-t3.1-t2.1", "type": "interacts_with", "arg1_id": "DerHautarzt.00510063.eng.abstr-s6-t3", "arg2_id": "DerHautarzt.00510063.eng.abstr-s6-t2", "normalized": [] }, { "id": "DerHautarzt.00510063.eng.abstr-s3-r6-t6.1-t1.1", "type": "interacts_with", "arg1_id": "DerHautarzt.00510063.eng.abstr-s6-t6", "arg2_id": "DerHautarzt.00510063.eng.abstr-s6-t1", "normalized": [] }, { "id": "DerHautarzt.00510063.eng.abstr-s3-r7-t3.1-t1.1", "type": "interacts_with", "arg1_id": "DerHautarzt.00510063.eng.abstr-s6-t3", "arg2_id": "DerHautarzt.00510063.eng.abstr-s6-t1", "normalized": [] }, { "id": "DerHautarzt.00510063.eng.abstr-s3-r8-t3.1-t5.1", "type": "affects", "arg1_id": "DerHautarzt.00510063.eng.abstr-s6-t3", "arg2_id": "DerHautarzt.00510063.eng.abstr-s6-t5", "normalized": [] }, { "id": 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"normalized": [] }, { "id": "DerHautarzt.00510063.eng.abstr-s4-r4-t2.1-t4.1", "type": "interacts_with", "arg1_id": "DerHautarzt.00510063.eng.abstr-s6-t2", "arg2_id": "DerHautarzt.00510063.eng.abstr-s6-t4", "normalized": [] }, { "id": "DerHautarzt.00510063.eng.abstr-s5-r1-t3.1-t5.1", "type": "produces", "arg1_id": "DerHautarzt.00510063.eng.abstr-s6-t3", "arg2_id": "DerHautarzt.00510063.eng.abstr-s6-t5", "normalized": [] }, { "id": "DerHautarzt.00510063.eng.abstr-s5-r2-t3.2-t1.1", "type": "performs", "arg1_id": "DerHautarzt.00510063.eng.abstr-s5-t3", "arg2_id": "DerHautarzt.00510063.eng.abstr-s6-t1", "normalized": [] }, { "id": "DerHautarzt.00510063.eng.abstr-s5-r3-t1.1-t5.1", "type": "uses", "arg1_id": "DerHautarzt.00510063.eng.abstr-s6-t1", "arg2_id": "DerHautarzt.00510063.eng.abstr-s6-t5", "normalized": [] }, { "id": "DerHautarzt.00510063.eng.abstr-s5-r4-t1.1-t3.2", "type": "associated_with", "arg1_id": "DerHautarzt.00510063.eng.abstr-s6-t1", "arg2_id": "DerHautarzt.00510063.eng.abstr-s5-t3", "normalized": [] }, { "id": "DerHautarzt.00510063.eng.abstr-s5-r5-t5.1-t3.1", "type": "disrupts", "arg1_id": "DerHautarzt.00510063.eng.abstr-s6-t5", "arg2_id": "DerHautarzt.00510063.eng.abstr-s6-t3", "normalized": [] }, { "id": "DerHautarzt.00510063.eng.abstr-s5-r6-t1.1-t3.2", "type": "affects", "arg1_id": "DerHautarzt.00510063.eng.abstr-s6-t1", "arg2_id": "DerHautarzt.00510063.eng.abstr-s5-t3", "normalized": [] }, { "id": "DerHautarzt.00510063.eng.abstr-s5-r7-t3.1-t1.1", "type": "location_of", "arg1_id": "DerHautarzt.00510063.eng.abstr-s6-t3", "arg2_id": "DerHautarzt.00510063.eng.abstr-s6-t1", "normalized": [] }, { "id": "DerHautarzt.00510063.eng.abstr-s6-r1-t7.1-t1.1", "type": "issue_in", "arg1_id": "DerHautarzt.00510063.eng.abstr-s6-t7", "arg2_id": "DerHautarzt.00510063.eng.abstr-s6-t1", "normalized": [] }, { "id": "DerHautarzt.00510063.eng.abstr-s6-r2-t5.1-t3.1", "type": "interacts_with", "arg1_id": "DerHautarzt.00510063.eng.abstr-s6-t5", "arg2_id": "DerHautarzt.00510063.eng.abstr-s6-t3", "normalized": [] }, { "id": "DerHautarzt.00510063.eng.abstr-s6-r3-t4.1-t1.1", "type": "issue_in", "arg1_id": "DerHautarzt.00510063.eng.abstr-s6-t4", "arg2_id": "DerHautarzt.00510063.eng.abstr-s6-t1", "normalized": [] }, { "id": "DerHautarzt.00510063.eng.abstr-s6-r4-t8.1-t1.1", "type": "issue_in", "arg1_id": "DerHautarzt.00510063.eng.abstr-s6-t8", "arg2_id": "DerHautarzt.00510063.eng.abstr-s6-t1", "normalized": [] }, { "id": "DerHautarzt.00510063.eng.abstr-s6-r5-t5.1-t4.1", "type": "affects", "arg1_id": "DerHautarzt.00510063.eng.abstr-s6-t5", "arg2_id": "DerHautarzt.00510063.eng.abstr-s6-t4", "normalized": [] }, { "id": "DerHautarzt.00510063.eng.abstr-s6-r6-t5.1-t2.1", "type": "interacts_with", "arg1_id": "DerHautarzt.00510063.eng.abstr-s6-t5", "arg2_id": "DerHautarzt.00510063.eng.abstr-s6-t2", "normalized": [] }, { "id": "DerHautarzt.00510063.eng.abstr-s6-r7-t5.1-t7.1", "type": "affects", "arg1_id": "DerHautarzt.00510063.eng.abstr-s6-t5", "arg2_id": "DerHautarzt.00510063.eng.abstr-s6-t7", "normalized": [] }, { "id": "DerHautarzt.00510063.eng.abstr-s6-r8-t5.1-t1.1", "type": "issue_in", "arg1_id": "DerHautarzt.00510063.eng.abstr-s6-t5", "arg2_id": "DerHautarzt.00510063.eng.abstr-s6-t1", "normalized": [] } ]
DerHautarzt.00510070.eng.abstr	DerHautarzt.00510070.eng.abstr	[ { "id": "DerHautarzt.00510070.eng.abstr-passage-0", "type": "abstract", "text": [ "Objective . The volume flow in the common femoral vein ( SV ) as a representative parameter of the venous hemodynamics of the leg can be measured using duplex-sonography . A direct correlation between the SV-data and the clinical grade of the venous disease was postulated ." ], "offsets": [ [ 0, 274 ] ] } ]	[ { "id": "DerHautarzt.00510070.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Objective" ], "offsets": [ [ 0, 9 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018017" } ] }, { "id": "DerHautarzt.00510070.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "vein" ], "offsets": [ [ 50, 54 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042449" } ] }, { "id": "DerHautarzt.00510070.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "hemodynamics" ], "offsets": [ [ 106, 118 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019010" } ] }, { "id": "DerHautarzt.00510070.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "leg" ], "offsets": [ [ 126, 129 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023216" } ] }, { "id": "DerHautarzt.00510070.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "femoral vein" ], "offsets": [ [ 42, 54 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015809" } ] }, { "id": "DerHautarzt.00510070.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "direct" ], "offsets": [ [ 174, 180 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0700157" } ] }, { "id": "DerHautarzt.00510070.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 250, 257 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] } ]	[]	[]	[ { "id": "DerHautarzt.00510070.eng.abstr-s2-r1-t1.1-t3.1", "type": "adjacent_to", "arg1_id": "DerHautarzt.00510070.eng.abstr-s3-t1", "arg2_id": "DerHautarzt.00510070.eng.abstr-s2-t3", "normalized": [] }, { "id": "DerHautarzt.00510070.eng.abstr-s2-r2-t3.1-t4.1", "type": "adjacent_to", "arg1_id": "DerHautarzt.00510070.eng.abstr-s2-t3", "arg2_id": "DerHautarzt.00510070.eng.abstr-s2-t4", "normalized": [] }, { "id": "DerHautarzt.00510070.eng.abstr-s2-r3-t1.1-t2.1", "type": "location_of", "arg1_id": "DerHautarzt.00510070.eng.abstr-s3-t1", "arg2_id": "DerHautarzt.00510070.eng.abstr-s3-t2", "normalized": [] }, { "id": "DerHautarzt.00510070.eng.abstr-s2-r4-t3.1-t1.1", "type": "adjacent_to", "arg1_id": "DerHautarzt.00510070.eng.abstr-s2-t3", "arg2_id": "DerHautarzt.00510070.eng.abstr-s3-t1", "normalized": [] }, { "id": "DerHautarzt.00510070.eng.abstr-s2-r5-t4.1-t3.1", "type": "adjacent_to", "arg1_id": "DerHautarzt.00510070.eng.abstr-s2-t4", "arg2_id": "DerHautarzt.00510070.eng.abstr-s2-t3", "normalized": [] }, { "id": "DerHautarzt.00510070.eng.abstr-s2-r6-t4.1-t2.1", "type": "location_of", "arg1_id": "DerHautarzt.00510070.eng.abstr-s2-t4", "arg2_id": "DerHautarzt.00510070.eng.abstr-s3-t2", "normalized": [] }, { "id": "DerHautarzt.00510070.eng.abstr-s2-r7-t3.1-t2.1", "type": "location_of", "arg1_id": "DerHautarzt.00510070.eng.abstr-s2-t3", "arg2_id": "DerHautarzt.00510070.eng.abstr-s3-t2", "normalized": [] } ]
DerHautarzt.00510075.eng.abstr	DerHautarzt.00510075.eng.abstr	[ { "id": "DerHautarzt.00510075.eng.abstr-passage-0", "type": "abstract", "text": [ "Scabies is an infectious parasitic skin disease with a notable rising incidence in Germany . The disease is usually transmitted by close physical contact , but indirect spread e.g. by bedding is also possible . Due to its contagiousness , introduction of scabies into crowding living facilities , such as dormitories or kindergartens , can easily cause an epidemic outbreak . We describe an epidemic of scabies in a workshop for handicapped people in February 1998. A worker with severe scabies reported that numerous colleagues in both workshop and the associated hostel had complained of pruritus for months and that some of them already had undergone scabicide treatment . The number of contacts ( staff , colleagues , friends , attendants , family ) of our patient and the other already affected people was more than 460. The management of the workshop asked for help in handling the epidemic . We describe the cooperative efforts of the management , as well as hospital and private dermatologists , to evaluate all potential contacts and present a concept of treatment for the termination of such an epidemic outbreak of scabies ." ], "offsets": [ [ 0, 1135 ] ] } ]	[ { "id": "DerHautarzt.00510075.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Scabies" ], "offsets": [ [ 0, 7 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036262" } ] }, { "id": "DerHautarzt.00510075.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "parasitic" ], "offsets": [ [ 25, 34 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0521066" } ] }, { "id": "DerHautarzt.00510075.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "skin" ], "offsets": [ [ 35, 39 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] }, { "id": "DerHautarzt.00510075.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 40, 47 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { 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"db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510086.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "candidiasis" ], "offsets": [ [ 374, 385 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006840" } ] }, { "id": "DerHautarzt.00510086.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "dermatitis" ], "offsets": [ [ 406, 416 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011603" } ] }, { "id": "DerHautarzt.00510086.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "atopic dermatitis" ], "offsets": [ [ 399, 416 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011615" } ] }, { "id": "DerHautarzt.00510086.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 445, 452 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerHautarzt.00510086.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "penicillin" ], "offsets": [ [ 485, 495 ] ], "normalized": [ { "db_name": 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"type": "associated_with", "arg1_id": "DerHautarzt.00510086.eng.abstr-s5-t1", "arg2_id": "DerHautarzt.00510086.eng.abstr-s5-t4", "normalized": [] }, { "id": "DerHautarzt.00510086.eng.abstr-s3-r8-t4.1-t1.1", "type": "location_of", "arg1_id": "DerHautarzt.00510086.eng.abstr-s5-t4", "arg2_id": "DerHautarzt.00510086.eng.abstr-s5-t1", "normalized": [] }, { "id": "DerHautarzt.00510086.eng.abstr-s3-r10-t3.1-t1.2", "type": "causes", "arg1_id": "DerHautarzt.00510086.eng.abstr-s5-t3", "arg2_id": "DerHautarzt.00510086.eng.abstr-s5-t1", "normalized": [] }, { "id": "DerHautarzt.00510086.eng.abstr-s3-r11-t4.1-t1.2", "type": "associated_with", "arg1_id": "DerHautarzt.00510086.eng.abstr-s5-t4", "arg2_id": "DerHautarzt.00510086.eng.abstr-s5-t1", "normalized": [] }, { "id": "DerHautarzt.00510086.eng.abstr-s3-r12-t4.1-t3.1", "type": "property_of", "arg1_id": "DerHautarzt.00510086.eng.abstr-s5-t4", "arg2_id": "DerHautarzt.00510086.eng.abstr-s5-t3", "normalized": [] }, { "id": "DerHautarzt.00510086.eng.abstr-s5-r1-t1.1-t2.2", "type": "interacts_with", "arg1_id": "DerHautarzt.00510086.eng.abstr-s5-t1", "arg2_id": "DerHautarzt.00510086.eng.abstr-s5-t2", "normalized": [] }, { "id": "DerHautarzt.00510086.eng.abstr-s5-r2-t2.2-t1.1", "type": "interacts_with", "arg1_id": "DerHautarzt.00510086.eng.abstr-s5-t2", "arg2_id": "DerHautarzt.00510086.eng.abstr-s5-t1", "normalized": [] } ]
DerHautarzt.00510090.eng.abstr	DerHautarzt.00510090.eng.abstr	[ { "id": "DerHautarzt.00510090.eng.abstr-passage-0", "type": "abstract", "text": [ "Interstitial granulomatous dermatitis with arthritis is a rare dermatologic disorder seen in patients suffering from diseases in which circulating immune complexes occur . The typical cutaneous signs are linear cords usually located on the lateral aspect of the trunk . The characteristic , although not specific , histology reveals a dense diffuse infiltrate composed mostly of histiocytes , accompanied by neutrophils and eosinophils , and degenerated collagen surrounded by palisades of histiocytes . We discuss this disorder and its differential diagnosis ." ], "offsets": [ [ 0, 561 ] ] } ]	[ { "id": "DerHautarzt.00510090.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "dermatitis" ], "offsets": [ [ 27, 37 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011603" } ] }, { "id": "DerHautarzt.00510090.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "arthritis" ], "offsets": [ [ 43, 52 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003864" } ] }, { "id": "DerHautarzt.00510090.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "disorder" ], "offsets": [ [ 76, 84 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510090.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 93, 101 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510090.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "diseases" ], "offsets": [ [ 117, 125 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510090.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "dermatologic disorder" ], "offsets": [ [ 63, 84 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037274" } ] }, { "id": "DerHautarzt.00510090.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "immune complexes" ], "offsets": [ [ 147, 163 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003313" } ] }, { "id": "DerHautarzt.00510090.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "circulating immune complexes" ], "offsets": [ [ 135, 163 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003313" } ] }, { "id": "DerHautarzt.00510090.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "signs" ], "offsets": [ [ 194, 199 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220912" } ] }, { "id": "DerHautarzt.00510090.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "histology" ], "offsets": [ [ 315, 324 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019638" }, { "db_name": "UMLS", "db_id": "C0205462" } ] }, { "id": "DerHautarzt.00510090.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "histiocytes" ], "offsets": [ [ 379, 390 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019612" } ] }, { "id": "DerHautarzt.00510090.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "neutrophils" ], "offsets": [ [ 408, 419 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027950" } ] }, { "id": "DerHautarzt.00510090.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "eosinophils" ], "offsets": [ [ 424, 435 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014467" } ] }, { "id": "DerHautarzt.00510090.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "collagen" ], "offsets": [ [ 454, 462 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009325" } ] }, { "id": "DerHautarzt.00510090.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "histiocytes" ], "offsets": [ [ 490, 501 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019612" } ] }, { "id": "DerHautarzt.00510090.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "disorder" ], "offsets": [ [ 520, 528 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510090.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "diagnosis" ], "offsets": [ [ 550, 559 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011900" }, { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerHautarzt.00510090.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "differential diagnosis" ], "offsets": [ [ 537, 559 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220820" }, { "db_name": "UMLS", "db_id": "C0011906" } ] } ]	[]	[]	[ { "id": "DerHautarzt.00510090.eng.abstr-s1-r1-t7.1-t2.1", "type": "affects", "arg1_id": "DerHautarzt.00510090.eng.abstr-s1-t7", "arg2_id": "DerHautarzt.00510090.eng.abstr-s4-t2", "normalized": [] }, { "id": "DerHautarzt.00510090.eng.abstr-s1-r2-t7.1-t5.1", "type": "affects", "arg1_id": "DerHautarzt.00510090.eng.abstr-s1-t7", "arg2_id": "DerHautarzt.00510090.eng.abstr-s3-t5", "normalized": [] }, { "id": "DerHautarzt.00510090.eng.abstr-s1-r3-t8.1-t2.1", "type": "affects", "arg1_id": "DerHautarzt.00510090.eng.abstr-s1-t8", "arg2_id": "DerHautarzt.00510090.eng.abstr-s4-t2", "normalized": [] }, { "id": "DerHautarzt.00510090.eng.abstr-s1-r4-t7.1-t3.1", "type": "indicates", "arg1_id": "DerHautarzt.00510090.eng.abstr-s1-t7", "arg2_id": "DerHautarzt.00510090.eng.abstr-s4-t3", "normalized": [] }, { "id": "DerHautarzt.00510090.eng.abstr-s1-r5-t8.1-t5.1", "type": "affects", "arg1_id": "DerHautarzt.00510090.eng.abstr-s1-t8", "arg2_id": "DerHautarzt.00510090.eng.abstr-s3-t5", "normalized": [] }, { "id": "DerHautarzt.00510090.eng.abstr-s1-r6-t8.1-t7.1", "type": "interacts_with", "arg1_id": "DerHautarzt.00510090.eng.abstr-s1-t8", "arg2_id": "DerHautarzt.00510090.eng.abstr-s1-t7", "normalized": [] }, { "id": "DerHautarzt.00510090.eng.abstr-s1-r7-t7.1-t1.1", "type": "affects", "arg1_id": "DerHautarzt.00510090.eng.abstr-s1-t7", "arg2_id": "DerHautarzt.00510090.eng.abstr-s4-t1", "normalized": [] }, { "id": "DerHautarzt.00510090.eng.abstr-s1-r8-t8.1-t3.1", "type": "indicates", "arg1_id": "DerHautarzt.00510090.eng.abstr-s1-t8", "arg2_id": "DerHautarzt.00510090.eng.abstr-s4-t3", "normalized": [] }, { "id": "DerHautarzt.00510090.eng.abstr-s1-r9-t7.1-t2.1", "type": "indicates", "arg1_id": "DerHautarzt.00510090.eng.abstr-s1-t7", "arg2_id": "DerHautarzt.00510090.eng.abstr-s4-t2", "normalized": [] }, { "id": "DerHautarzt.00510090.eng.abstr-s1-r10-t8.1-t1.1", "type": "affects", "arg1_id": "DerHautarzt.00510090.eng.abstr-s1-t8", "arg2_id": "DerHautarzt.00510090.eng.abstr-s4-t1", "normalized": [] }, { "id": "DerHautarzt.00510090.eng.abstr-s1-r11-t7.1-t6.1", "type": "indicates", "arg1_id": "DerHautarzt.00510090.eng.abstr-s1-t7", "arg2_id": "DerHautarzt.00510090.eng.abstr-s3-t6", "normalized": [] }, { "id": "DerHautarzt.00510090.eng.abstr-s1-r12-t8.1-t2.1", "type": "indicates", "arg1_id": "DerHautarzt.00510090.eng.abstr-s1-t8", "arg2_id": "DerHautarzt.00510090.eng.abstr-s4-t2", "normalized": [] }, { "id": "DerHautarzt.00510090.eng.abstr-s1-r13-t8.1-t6.1", "type": "indicates", "arg1_id": "DerHautarzt.00510090.eng.abstr-s1-t8", "arg2_id": "DerHautarzt.00510090.eng.abstr-s3-t6", "normalized": [] }, { "id": "DerHautarzt.00510090.eng.abstr-s1-r14-t7.1-t1.1", "type": "indicates", "arg1_id": "DerHautarzt.00510090.eng.abstr-s1-t7", "arg2_id": "DerHautarzt.00510090.eng.abstr-s4-t1", "normalized": [] }, { "id": "DerHautarzt.00510090.eng.abstr-s1-r15-t7.1-t5.1", "type": "indicates", "arg1_id": "DerHautarzt.00510090.eng.abstr-s1-t7", "arg2_id": "DerHautarzt.00510090.eng.abstr-s3-t5", "normalized": [] }, { "id": "DerHautarzt.00510090.eng.abstr-s1-r16-t7.1-t3.1", "type": "affects", "arg1_id": "DerHautarzt.00510090.eng.abstr-s1-t7", "arg2_id": "DerHautarzt.00510090.eng.abstr-s4-t3", "normalized": [] }, { "id": "DerHautarzt.00510090.eng.abstr-s1-r17-t7.1-t6.1", "type": "affects", "arg1_id": "DerHautarzt.00510090.eng.abstr-s1-t7", "arg2_id": "DerHautarzt.00510090.eng.abstr-s3-t6", "normalized": [] }, { "id": "DerHautarzt.00510090.eng.abstr-s1-r18-t8.1-t3.1", "type": "affects", "arg1_id": "DerHautarzt.00510090.eng.abstr-s1-t8", "arg2_id": "DerHautarzt.00510090.eng.abstr-s4-t3", "normalized": [] }, { "id": "DerHautarzt.00510090.eng.abstr-s1-r19-t7.1-t8.1", "type": "interacts_with", "arg1_id": "DerHautarzt.00510090.eng.abstr-s1-t7", "arg2_id": "DerHautarzt.00510090.eng.abstr-s1-t8", "normalized": [] }, { "id": "DerHautarzt.00510090.eng.abstr-s1-r20-t8.1-t1.1", "type": "indicates", "arg1_id": "DerHautarzt.00510090.eng.abstr-s1-t8", "arg2_id": "DerHautarzt.00510090.eng.abstr-s4-t1", "normalized": [] }, { "id": "DerHautarzt.00510090.eng.abstr-s1-r21-t8.1-t5.1", "type": "indicates", "arg1_id": "DerHautarzt.00510090.eng.abstr-s1-t8", "arg2_id": "DerHautarzt.00510090.eng.abstr-s3-t5", "normalized": [] }, { "id": "DerHautarzt.00510090.eng.abstr-s1-r22-t8.1-t6.1", "type": "affects", "arg1_id": "DerHautarzt.00510090.eng.abstr-s1-t8", "arg2_id": "DerHautarzt.00510090.eng.abstr-s3-t6", "normalized": [] }, { "id": "DerHautarzt.00510090.eng.abstr-s3-r1-t5.1-t4.1", "type": "disrupts", "arg1_id": "DerHautarzt.00510090.eng.abstr-s3-t5", "arg2_id": "DerHautarzt.00510090.eng.abstr-s3-t4", "normalized": [] }, { "id": "DerHautarzt.00510090.eng.abstr-s3-r2-t5.1-t3.1", "type": "disrupts", "arg1_id": "DerHautarzt.00510090.eng.abstr-s3-t5", "arg2_id": "DerHautarzt.00510090.eng.abstr-s4-t3", "normalized": [] }, { "id": "DerHautarzt.00510090.eng.abstr-s3-r3-t5.1-t1.1", "type": "issue_in", "arg1_id": "DerHautarzt.00510090.eng.abstr-s3-t5", "arg2_id": "DerHautarzt.00510090.eng.abstr-s4-t1", "normalized": [] }, { "id": "DerHautarzt.00510090.eng.abstr-s3-r4-t5.1-t6.1", "type": "disrupts", "arg1_id": "DerHautarzt.00510090.eng.abstr-s3-t5", "arg2_id": "DerHautarzt.00510090.eng.abstr-s3-t6", "normalized": [] }, { "id": "DerHautarzt.00510090.eng.abstr-s3-r5-t5.1-t1.2", "type": "disrupts", "arg1_id": "DerHautarzt.00510090.eng.abstr-s3-t5", "arg2_id": "DerHautarzt.00510090.eng.abstr-s3-t1", "normalized": [] }, { "id": "DerHautarzt.00510090.eng.abstr-s3-r6-t1.2-t1.1", "type": "issue_in", "arg1_id": "DerHautarzt.00510090.eng.abstr-s3-t1", "arg2_id": "DerHautarzt.00510090.eng.abstr-s4-t1", "normalized": [] }, { "id": "DerHautarzt.00510090.eng.abstr-s4-r1-t2.1-t1.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510090.eng.abstr-s4-t2", "arg2_id": "DerHautarzt.00510090.eng.abstr-s4-t1", "normalized": [] }, { "id": "DerHautarzt.00510090.eng.abstr-s4-r2-t2.2-t1.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510090.eng.abstr-s4-t2", "arg2_id": "DerHautarzt.00510090.eng.abstr-s4-t1", "normalized": [] }, { "id": "DerHautarzt.00510090.eng.abstr-s4-r3-t1.1-t2.2", "type": "associated_with", "arg1_id": "DerHautarzt.00510090.eng.abstr-s4-t1", "arg2_id": "DerHautarzt.00510090.eng.abstr-s4-t2", "normalized": [] }, { "id": "DerHautarzt.00510090.eng.abstr-s4-r4-t1.1-t2.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510090.eng.abstr-s4-t1", "arg2_id": "DerHautarzt.00510090.eng.abstr-s4-t2", "normalized": [] } ]
DerHautarzt.00510095.eng.abstr	DerHautarzt.00510095.eng.abstr	[ { "id": "DerHautarzt.00510095.eng.abstr-passage-0", "type": "abstract", "text": [ "Autosomal recessive inheritance , intrauterine growth retardation , short stature , microcephaly , distinct facial dysmorphism , psychomotoric retardation , and often uncharacterized eczematous skin lesions distinguish the rare Dubowitz syndrome . Here a pair of monozygotic twins with Dubowitz syndrome and clear-cut atopic eczema is presented ." ], "offsets": [ [ 0, 346 ] ] } ]	[ { "id": "DerHautarzt.00510095.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "inheritance" ], "offsets": [ [ 20, 31 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242538" } ] }, { "id": "DerHautarzt.00510095.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "growth" ], "offsets": [ [ 47, 53 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018270" }, { "db_name": "UMLS", "db_id": "C0220844" } ] }, { "id": "DerHautarzt.00510095.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "microcephaly" ], "offsets": [ [ 84, 96 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025958" } ] }, { "id": "DerHautarzt.00510095.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "dysmorphism" ], "offsets": [ [ 115, 126 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000768" } ] }, { "id": "DerHautarzt.00510095.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "skin" ], "offsets": [ [ 194, 198 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] }, { "id": "DerHautarzt.00510095.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "syndrome" ], "offsets": [ [ 237, 245 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "DerHautarzt.00510095.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "intrauterine growth retardation" ], "offsets": [ [ 34, 65 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015934" } ] }, { "id": "DerHautarzt.00510095.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "eczematous skin lesions" ], "offsets": [ [ 183, 206 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013595" } ] }, { "id": "DerHautarzt.00510095.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "twins" ], "offsets": [ [ 275, 280 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0041426" }, { "db_name": "UMLS", "db_id": "C0041427" } ] }, { "id": "DerHautarzt.00510095.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "syndrome" ], "offsets": [ [ 295, 303 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "DerHautarzt.00510095.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "eczema" ], "offsets": [ [ 325, 331 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013595" } ] }, { "id": "DerHautarzt.00510095.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "monozygotic twins" ], "offsets": [ [ 263, 280 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0041432" } ] }, { "id": "DerHautarzt.00510095.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "atopic eczema" ], "offsets": [ [ 318, 331 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011615" } ] } ]	[]	[]	[ { "id": "DerHautarzt.00510095.eng.abstr-s1-r1-t7.1-t2.2", "type": "result_of", "arg1_id": "DerHautarzt.00510095.eng.abstr-s1-t7", "arg2_id": "DerHautarzt.00510095.eng.abstr-s1-t2", "normalized": [] }, { "id": "DerHautarzt.00510095.eng.abstr-s1-r2-t7.1-t5.1", "type": "evaluation_of", "arg1_id": 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Though vulvodynia is often accompanied by psychological distress , somatic causes have to be considered in each case ." ], "offsets": [ [ 0, 537 ] ] } ]	[ { "id": "DerHautarzt.00510147.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "syndrome" ], "offsets": [ [ 24, 32 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "DerHautarzt.00510147.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 51, 55 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerHautarzt.00510147.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "vulvovaginitis" ], "offsets": [ [ 106, 120 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042998" } ] }, { "id": "DerHautarzt.00510147.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 123, 127 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerHautarzt.00510147.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "coitus" ], "offsets": [ [ 141, 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"db_name": "UMLS", "db_id": "C0037274" } ] }, { "id": "DerHautarzt.00510147.eng.abstr-s2-t9", "type": "umlsterm", "text": [ "pemphigus" ], "offsets": [ [ 319, 328 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030807" } ] }, { "id": "DerHautarzt.00510147.eng.abstr-s2-t10", "type": "umlsterm", "text": [ "dermatitis" ], "offsets": [ [ 348, 358 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011603" } ] }, { "id": "DerHautarzt.00510147.eng.abstr-s2-t11", "type": "umlsterm", "text": [ "pemphigus vulgaris" ], "offsets": [ [ 319, 337 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030809" } ] }, { "id": "DerHautarzt.00510147.eng.abstr-s2-t12", "type": "umlsterm", "text": [ "contact dermatitis" ], "offsets": [ [ 340, 358 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011616" } ] }, { "id": "DerHautarzt.00510147.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "causes" ], "offsets": [ [ 374, 380 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015127" } ] }, { 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DerHautarzt.00510152.eng.abstr	DerHautarzt.00510152.eng.abstr	[ { "id": "DerHautarzt.00510152.eng.abstr-passage-0", "type": "abstract", "text": [ "The neodymium : yttrium-aluminium-garnet- ( Nd : YAG ) laser is one of the most versatile and interesting lasers in dermatological laser medicine . Almost no other laser has such a wide spectrum of applications . Depending on wave length ( 1064 nm , frequency-doubled 532 nm ) and mode ( continuous , Q-switched , longpulsed ) , benign pigmented lesions ( tattoos , traumatic tattoos , naevus of Ota , cafe-aut-lait-macules , lentigines ) and vascular lesions ( hemangiomas , portwine stains , essential teleangiectasias , angiomas ) can be treated . Additionally this laser has been occasionally used to remove Kaposi sarcomas and epithelial skin tumors ." ], "offsets": [ [ 0, 656 ] ] } ]	[ { "id": "DerHautarzt.00510152.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "neodymium" ], "offsets": [ [ 4, 13 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027599" } ] }, { "id": "DerHautarzt.00510152.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "laser" ], "offsets": [ [ 55, 60 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023089" } ] }, { "id": "DerHautarzt.00510152.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "lasers" ], "offsets": [ [ 106, 112 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023089" } ] }, { "id": "DerHautarzt.00510152.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "laser" ], "offsets": [ [ 131, 136 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023089" } ] }, { "id": "DerHautarzt.00510152.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "medicine" ], "offsets": [ [ 137, 145 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025118" }, { "db_name": "UMLS", "db_id": "C0013227" } ] }, { "id": "DerHautarzt.00510152.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "laser" ], "offsets": [ [ 164, 169 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023089" } ] }, { "id": "DerHautarzt.00510152.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "tattoos" ], "offsets": [ [ 356, 363 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039343" } ] }, { "id": "DerHautarzt.00510152.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "tattoos" ], "offsets": [ [ 376, 383 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039343" } ] }, { "id": "DerHautarzt.00510152.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "naevus" ], "offsets": [ [ 386, 392 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027960" } ] }, { "id": "DerHautarzt.00510152.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "lentigines" ], "offsets": [ [ 426, 436 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023321" } ] }, { "id": "DerHautarzt.00510152.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "hemangiomas" ], "offsets": [ [ 462, 473 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018916" } ] }, { "id": "DerHautarzt.00510152.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "stains" ], "offsets": [ [ 485, 491 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038128" }, { "db_name": "UMLS", "db_id": "C0038129" } ] }, { "id": "DerHautarzt.00510152.eng.abstr-s3-t7", "type": "umlsterm", "text": [ "angiomas" ], "offsets": [ [ 523, 531 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018916" } ] }, { "id": "DerHautarzt.00510152.eng.abstr-s3-t8", "type": "umlsterm", "text": [ "portwine stains" ], "offsets": [ [ 476, 491 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0235752" } ] }, { "id": "DerHautarzt.00510152.eng.abstr-s3-t9", "type": "umlsterm", "text": [ "naevus of Ota" ], "offsets": [ [ 386, 399 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027961" } ] }, { "id": "DerHautarzt.00510152.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "laser" ], "offsets": [ [ 569, 574 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023089" } ] }, { "id": "DerHautarzt.00510152.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "sarcomas" ], "offsets": [ [ 619, 627 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036210" } ] }, { "id": "DerHautarzt.00510152.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "skin" ], "offsets": [ [ 643, 647 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] }, { "id": "DerHautarzt.00510152.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "tumors" ], "offsets": [ [ 648, 654 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerHautarzt.00510152.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "Kaposi sarcomas" ], "offsets": [ [ 612, 627 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036220" } ] }, { "id": "DerHautarzt.00510152.eng.abstr-s4-t6", "type": 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DerHautarzt.00510159.eng.abstr	DerHautarzt.00510159.eng.abstr	[ { "id": "DerHautarzt.00510159.eng.abstr-passage-0", "type": "abstract", "text": [ "Since the availability of protease inhibitors in 1997 , there has been a great change in antiretroviral therapy but also new long term side effects have emerged , mainly metabolic changes such as hypertriglyceridemia , hypercholesterinemia and hyperglycemia . Besides , fat redistribution has been observed . Fat wastes in the face and limbs but accumulates in the adipose tissue of the dorsocervical and abdominal region and the breasts . The mechanism of these changes remains unclear . For therapy a protease inhibitor free therapy or lipid lowering drugs may be tried . 29 of our 224 patients developed lipodystrophy . 27 of these patients had been treated with a protease inhibitor ( 17 patients with indinavir ) ; 2 of the patients had never received protease inhibitors ." ], "offsets": [ [ 0, 778 ] ] } ]	[ { "id": "DerHautarzt.00510159.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "protease" ], "offsets": [ [ 26, 34 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030946" } ] }, { "id": "DerHautarzt.00510159.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "inhibitors" ], "offsets": [ [ 35, 45 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243077" } ] }, { "id": "DerHautarzt.00510159.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 104, 111 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerHautarzt.00510159.eng.abstr-s1-t4", "type": "umlsterm", "text": [ 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"normalized": [ { "db_name": "UMLS", "db_id": "C0015677" } ] }, { "id": "DerHautarzt.00510159.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "face" ], "offsets": [ [ 327, 331 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015450" } ] }, { "id": "DerHautarzt.00510159.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "limbs" ], "offsets": [ [ 336, 341 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015385" } ] }, { "id": "DerHautarzt.00510159.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "tissue" ], "offsets": [ [ 373, 379 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040300" } ] }, { "id": "DerHautarzt.00510159.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "breasts" ], "offsets": [ [ 430, 437 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006141" }, { "db_name": "UMLS", "db_id": "C0006142" } ] }, { "id": "DerHautarzt.00510159.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "adipose tissue" ], "offsets": [ [ 365, 379 ] ], "normalized": [ { "db_name": 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"db_name": "UMLS", "db_id": "C0023779" } ] }, { "id": "DerHautarzt.00510159.eng.abstr-s5-t6", "type": "umlsterm", "text": [ "drugs" ], "offsets": [ [ 553, 558 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013227" } ] }, { "id": "DerHautarzt.00510159.eng.abstr-s5-t7", "type": "umlsterm", "text": [ "protease inhibitor" ], "offsets": [ [ 503, 521 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033607" } ] }, { "id": "DerHautarzt.00510159.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 588, 596 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510159.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "lipodystrophy" ], "offsets": [ [ 607, 620 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011859" }, { "db_name": "UMLS", "db_id": "C0023787" } ] }, { "id": "DerHautarzt.00510159.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 635, 643 ] ], "normalized": [ { "db_name": "UMLS", 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DerHautarzt.00510164.eng.abstr	DerHautarzt.00510164.eng.abstr	[ { "id": "DerHautarzt.00510164.eng.abstr-passage-0", "type": "abstract", "text": [ "Background and Objectives . Treatment of pruritus as observed in many dermatological and internal diseases may be very often disappointing . There are many reports describing the topical use of capsaicin , the pungent agent in red pepper . Long term administration of capsaicin depletes neuropeptides in unmyelinated , polymodal C-type and small myelinated A-type cutaneous nerves that conduct pruritus and pain ." ], "offsets": [ [ 0, 413 ] ] } ]	[ { "id": "DerHautarzt.00510164.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Objectives" ], "offsets": [ [ 15, 25 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018017" } ] }, { "id": "DerHautarzt.00510164.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "Treatment" ], "offsets": [ [ 28, 37 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerHautarzt.00510164.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "pruritus" ], "offsets": [ [ 41, 49 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033778" }, { "db_name": "UMLS", "db_id": "C0033774" } ] }, { "id": "DerHautarzt.00510164.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "diseases" ], "offsets": [ [ 98, 106 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510164.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "use" ], "offsets": [ [ 187, 190 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042153" } ] }, { "id": "DerHautarzt.00510164.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "capsaicin" ], "offsets": [ [ 194, 203 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006931" } ] }, { "id": "DerHautarzt.00510164.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "red pepper" ], "offsets": [ [ 227, 237 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0446306" } ] }, { "id": "DerHautarzt.00510164.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "administration" ], "offsets": [ [ 250, 264 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001554" } ] }, { "id": "DerHautarzt.00510164.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "capsaicin" ], "offsets": [ [ 268, 277 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006931" } ] }, { "id": "DerHautarzt.00510164.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "neuropeptides" ], "offsets": [ [ 287, 300 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027895" } ] }, { "id": "DerHautarzt.00510164.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "nerves" ], "offsets": [ [ 374, 380 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027769" } ] }, { "id": "DerHautarzt.00510164.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "conduct" ], "offsets": [ [ 386, 393 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004927" } ] }, { "id": "DerHautarzt.00510164.eng.abstr-s4-t6", "type": "umlsterm", "text": [ "pruritus" ], "offsets": [ [ 394, 402 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033778" }, { "db_name": "UMLS", "db_id": "C0033774" } ] }, { "id": "DerHautarzt.00510164.eng.abstr-s4-t7", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 407, 411 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] } ]	[]	[]	[ { "id": 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DerHautarzt.00510173.eng.abstr	DerHautarzt.00510173.eng.abstr	[ { "id": "DerHautarzt.00510173.eng.abstr-passage-0", "type": "abstract", "text": [ "Background and Objective . Keratoacanthoma are benign epithelial tumors . The aim of this study was to determine the effects of interferon alpha on keratoacanthoma ." ], "offsets": [ [ 0, 165 ] ] } ]	[ { "id": "DerHautarzt.00510173.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Objective" ], "offsets": [ [ 15, 24 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018017" } ] }, { "id": "DerHautarzt.00510173.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "Keratoacanthoma" ], "offsets": [ [ 27, 42 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022572" } ] }, { "id": "DerHautarzt.00510173.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "tumors" ], "offsets": [ [ 65, 71 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerHautarzt.00510173.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "epithelial tumors" ], "offsets": [ [ 54, 71 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0205853" } ] }, { "id": "DerHautarzt.00510173.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "aim" ], "offsets": [ [ 78, 81 ] ], 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Treatment of radiation-induced acne is comedolytic ; topical retinoids are especially valuable ." ], "offsets": [ [ 0, 764 ] ] } ]	[ { "id": "DerHautarzt.00510187.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "acne" ], "offsets": [ [ 18, 22 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001144" } ] }, { "id": "DerHautarzt.00510187.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "dermatosis" ], "offsets": [ [ 89, 99 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037274" } ] }, { "id": "DerHautarzt.00510187.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "skin" ], "offsets": [ [ 151, 155 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] }, { "id": "DerHautarzt.00510187.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "radiation" ], "offsets": [ [ 212, 221 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0851346" } ] }, { "id": "DerHautarzt.00510187.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 239, 246 ] ], "normalized": [ 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DerHautarzt.00510192.eng.abstr	DerHautarzt.00510192.eng.abstr	[ { "id": "DerHautarzt.00510192.eng.abstr-passage-0", "type": "abstract", "text": [ "Pachyonychia congenita ( PC ) is a rare ectodermal dysplasia with variable expression . The condition is usually inherited as an autosomal dominant trait . Several classifications of PC have been proposed . Feinstein and colleagues suggested four clinical types of PC . Type II , the Jackson-Lawler-Syndrome , is characterized by multiple epidermal cysts , palmoplantar bullae and hyperhidrosis as well as natal teeth in addition to the main findings of pachyonychia , palmoplantar hyperkeratosis and follicular keratosis . We report two patients ( father and son ) with Jackson-Lawler-Syndrome and describe in detail pathogenesis , diagnostic criteria and treatment approaches as well as the different classifications of pachyonychia congenita ." ], "offsets": [ [ 0, 746 ] ] } ]	[ { "id": "DerHautarzt.00510192.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "ectodermal dysplasia" ], "offsets": [ [ 40, 60 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013575" } ] }, { "id": "DerHautarzt.00510192.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "classifications" ], "offsets": [ [ 164, 179 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008902" }, { "db_name": "UMLS", "db_id": "C0008903" } ] }, { "id": "DerHautarzt.00510192.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "cysts" ], "offsets": [ [ 349, 354 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010709" } ] }, { "id": "DerHautarzt.00510192.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "bullae" ], "offsets": [ [ 370, 376 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005758" } ] }, { "id": "DerHautarzt.00510192.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "hyperhidrosis" ], "offsets": [ [ 381, 394 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020458" } ] }, { "id": "DerHautarzt.00510192.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "hyperhidrosis" ], "offsets": [ [ 381, 394 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038990" } ] }, { "id": "DerHautarzt.00510192.eng.abstr-s5-t5", "type": "umlsterm", "text": [ "teeth" ], "offsets": [ [ 412, 417 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040426" } ] }, { "id": "DerHautarzt.00510192.eng.abstr-s5-t6", "type": "umlsterm", "text": [ "findings" ], "offsets": [ [ 442, 450 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243095" } ] }, { "id": "DerHautarzt.00510192.eng.abstr-s5-t7", "type": "umlsterm", "text": [ "hyperkeratosis" ], "offsets": [ [ 482, 496 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0751995" } ] }, { "id": "DerHautarzt.00510192.eng.abstr-s5-t8", "type": "umlsterm", "text": [ "keratosis" ], "offsets": [ [ 512, 521 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022593" } ] }, { "id": "DerHautarzt.00510192.eng.abstr-s5-t9", "type": "umlsterm", "text": [ "epidermal cysts" ], "offsets": [ [ 339, 354 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014511" } ] }, { "id": "DerHautarzt.00510192.eng.abstr-s5-t10", "type": "umlsterm", "text": [ "natal teeth" ], "offsets": [ [ 406, 417 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027443" } ] }, { "id": "DerHautarzt.00510192.eng.abstr-s5-t11", "type": "umlsterm", "text": [ "follicular keratosis" ], "offsets": [ [ 501, 521 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022595" } ] }, { "id": "DerHautarzt.00510192.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 538, 546 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510192.eng.abstr-s6-t2", 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DerHautarzt.00510196.eng.abstr	DerHautarzt.00510196.eng.abstr	[ { "id": "DerHautarzt.00510196.eng.abstr-passage-0", "type": "abstract", "text": [ "Therapy of Darier disease is rarely satisfactory . Oral retinoids can improve the skin lesions . Because of previous positive results with topical retinoids , which were often not practical because of marked skin irritation , two patients were treated with the new , topical acetylene-retinoid tazarotene in a 0.01% gel preparation . In both patients skin cleared within 2 to 4 weeks . After stopping the medication patients did not develop any new skin lesions for 12 months . In a third patient , healing with tazarotene gel 0.025% was faster than with a topical preparation containing 10% urea . Tazarotene is an important addition to the therapeutic possibilities in Darier disease ." ], "offsets": [ [ 0, 687 ] ] } ]	[ { "id": "DerHautarzt.00510196.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Therapy" ], "offsets": [ [ 0, 7 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerHautarzt.00510196.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 18, 25 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510196.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "Darier disease" ], "offsets": [ [ 11, 25 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022595" } ] }, { "id": "DerHautarzt.00510196.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "retinoids" ], "offsets": [ [ 56, 65 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035339" } ] }, { "id": "DerHautarzt.00510196.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "skin" ], 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DerHautarzt.00510201.eng.abstr	DerHautarzt.00510201.eng.abstr	[ { "id": "DerHautarzt.00510201.eng.abstr-passage-0", "type": "abstract", "text": [ "We describe a young man presenting with dreadlocks . There are remarkable similarities with the so called plica polonica , that historically had been treated with long courses of mercury . Apparently very important in the 18th century , the interest for this hairdisorder appears to be lost in specialized medical literature . In contrast dreadlocks , a recent hairstyle are frequently encountered . Lack of other sources various websites provide dermatologists with answers to questions regarding complications . Fortunately a simply haircut is today treatment enough ." ], "offsets": [ [ 0, 570 ] ] } ]	[ { "id": "DerHautarzt.00510201.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "man" ], "offsets": [ [ 20, 23 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025266" }, { "db_name": "UMLS", "db_id": "C0024554" } ] }, { "id": "DerHautarzt.00510201.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "mercury" ], "offsets": [ [ 179, 186 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025424" } ] }, { "id": "DerHautarzt.00510201.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "hairdisorder" ], "offsets": [ [ 259, 271 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018494" } ] }, { "id": "DerHautarzt.00510201.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "hairdisorder" ], "offsets": [ [ 259, 271 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510201.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "literature" ], "offsets": [ [ 314, 324 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023866" } ] }, { "id": "DerHautarzt.00510201.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "contrast" ], "offsets": [ [ 330, 338 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0110625" } ] }, { "id": "DerHautarzt.00510201.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "complications" ], "offsets": [ [ 498, 511 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009566" } ] }, { "id": "DerHautarzt.00510201.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 552, 561 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] } ]	[]	[]	[ { "id": "DerHautarzt.00510201.eng.abstr-s3-r1-t2.1-t1.1", "type": "produces", "arg1_id": "DerHautarzt.00510201.eng.abstr-s3-t2", "arg2_id": "DerHautarzt.00510201.eng.abstr-s6-t1", "normalized": [] }, { "id": "DerHautarzt.00510201.eng.abstr-s3-r2-t1.1-t2.1", "type": "causes", "arg1_id": "DerHautarzt.00510201.eng.abstr-s6-t1", "arg2_id": "DerHautarzt.00510201.eng.abstr-s3-t2", "normalized": [] } ]
DerHautarzt.00510223.eng.abstr	DerHautarzt.00510223.eng.abstr	[ { "id": "DerHautarzt.00510223.eng.abstr-passage-0", "type": "abstract", "text": [ "Since the skin and its appendages are androgen-dependent , male hypogonadism can be associated with dermatologically relevent lesions . The skin surface of hypogonadal patients is thin and shows increased wrinkles . In cases of prepubertal hypogonadism , severe acne does not occur . In contrast , patients may suffer from sebostasis due to missing stimulation of the sebaceous glands . The genital skin does not show pigmentation , which normaly develops during puberty ; the integument is pale . Hair growth on breast , pubia , axilla , face and integument is reduced ; patients do not present with typical androgenetic alopecia . In addition to these features , dermatological diseases caused by treatment of the hypogonadism or drug-induced skin reactions have to be considered . While drug reactions to oral or intramuscular androgens or gonadotropins are rare , irritative or allergic skin lesions are observed frequently , especially in cases of non-scrotal transdermal therapeutic systems with testosterone . A variety of syndromes include dermatological symptoms associated with male hypogonadism ; however , the prevalence of these syndromes is low ." ], "offsets": [ [ 0, 1160 ] ] } ]	[ { "id": "DerHautarzt.00510223.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "skin" ], "offsets": [ [ 10, 14 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] }, { "id": "DerHautarzt.00510223.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "androgen-dependent" ], "offsets": [ [ 38, 56 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002844" } ] }, { "id": "DerHautarzt.00510223.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "male" ], "offsets": [ [ 59, 63 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024554" }, { "db_name": "UMLS", "db_id": "C0086582" } ] }, { "id": "DerHautarzt.00510223.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "hypogonadism" ], "offsets": [ [ 64, 76 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020619" } ] }, { "id": "DerHautarzt.00510223.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "relevent" ], "offsets": [ [ 117, 125 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035018" } ] }, { "id": "DerHautarzt.00510223.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "skin" ], "offsets": [ [ 140, 144 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] }, { "id": "DerHautarzt.00510223.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 168, 176 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510223.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "wrinkles" ], "offsets": [ [ 205, 213 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037301" } ] }, { "id": "DerHautarzt.00510223.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "hypogonadism" ], "offsets": [ [ 240, 252 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020619" } ] }, { "id": "DerHautarzt.00510223.eng.abstr-s3-t2", "type": "umlsterm", "text": [ 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"text": [ "gonadotropins" ], "offsets": [ [ 843, 856 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018061" } ] }, { "id": "DerHautarzt.00510223.eng.abstr-s8-t4", "type": "umlsterm", "text": [ "skin" ], "offsets": [ [ 891, 895 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] }, { "id": "DerHautarzt.00510223.eng.abstr-s8-t5", "type": "umlsterm", "text": [ "therapeutic" ], "offsets": [ [ 977, 988 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "DerHautarzt.00510223.eng.abstr-s8-t6", "type": "umlsterm", "text": [ "testosterone" ], "offsets": [ [ 1002, 1014 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039601" } ] }, { "id": "DerHautarzt.00510223.eng.abstr-s9-t1", "type": "umlsterm", "text": [ "syndromes" ], "offsets": [ [ 1030, 1039 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "DerHautarzt.00510223.eng.abstr-s9-t2", "type": "umlsterm", "text": [ "symptoms" ], "offsets": [ [ 1063, 1071 ] ], 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DerHautarzt.00510231.eng.abstr	DerHautarzt.00510231.eng.abstr	[ { "id": "DerHautarzt.00510231.eng.abstr-passage-0", "type": "abstract", "text": [ "Background and objective . Cryosurgery is a widely accepted modality for the treatment of capillary hemangiomas of the newborn . However , no studies clearly supporting its effectivity are available ." ], "offsets": [ [ 0, 200 ] ] } ]	[ { "id": "DerHautarzt.00510231.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "objective" ], "offsets": [ [ 15, 24 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018017" } ] }, { "id": "DerHautarzt.00510231.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "Cryosurgery" ], "offsets": [ [ 27, 38 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010408" } ] }, { "id": "DerHautarzt.00510231.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 77, 86 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerHautarzt.00510231.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "capillary" ], "offsets": [ [ 90, 99 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006901" } ] }, { "id": "DerHautarzt.00510231.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "hemangiomas" ], "offsets": [ [ 100, 111 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018916" } ] }, { "id": "DerHautarzt.00510231.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "newborn" ], "offsets": [ [ 119, 126 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021289" } ] }, { "id": "DerHautarzt.00510231.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "capillary hemangiomas" ], "offsets": [ [ 90, 111 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0206733" } ] } ]	[]	[]	[ { "id": "DerHautarzt.00510231.eng.abstr-s2-r1-t4.1-t2.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510231.eng.abstr-s2-t4", "arg2_id": "DerHautarzt.00510231.eng.abstr-s2-t2", "normalized": [] }, { "id": "DerHautarzt.00510231.eng.abstr-s2-r2-t4.1-t5.1", "type": "occurs_in", "arg1_id": "DerHautarzt.00510231.eng.abstr-s2-t4", "arg2_id": "DerHautarzt.00510231.eng.abstr-s2-t5", "normalized": [] }, { "id": "DerHautarzt.00510231.eng.abstr-s2-r3-t2.1-t6.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510231.eng.abstr-s2-t2", "arg2_id": "DerHautarzt.00510231.eng.abstr-s2-t6", "normalized": [] }, { "id": "DerHautarzt.00510231.eng.abstr-s2-r4-t4.1-t1.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510231.eng.abstr-s2-t4", "arg2_id": "DerHautarzt.00510231.eng.abstr-s2-t1", "normalized": [] }, { "id": "DerHautarzt.00510231.eng.abstr-s2-r5-t2.1-t4.1", "type": "location_of", "arg1_id": "DerHautarzt.00510231.eng.abstr-s2-t2", "arg2_id": "DerHautarzt.00510231.eng.abstr-s2-t4", "normalized": [] }, { "id": "DerHautarzt.00510231.eng.abstr-s2-r6-t5.1-t2.1", "type": "performs", "arg1_id": "DerHautarzt.00510231.eng.abstr-s2-t5", "arg2_id": "DerHautarzt.00510231.eng.abstr-s2-t2", "normalized": [] }, { "id": "DerHautarzt.00510231.eng.abstr-s2-r7-t2.1-t1.1", "type": "location_of", "arg1_id": "DerHautarzt.00510231.eng.abstr-s2-t2", "arg2_id": "DerHautarzt.00510231.eng.abstr-s2-t1", "normalized": [] }, { "id": "DerHautarzt.00510231.eng.abstr-s2-r8-t2.1-t4.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510231.eng.abstr-s2-t2", "arg2_id": "DerHautarzt.00510231.eng.abstr-s2-t4", "normalized": [] }, { "id": "DerHautarzt.00510231.eng.abstr-s2-r9-t6.1-t2.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510231.eng.abstr-s2-t6", "arg2_id": "DerHautarzt.00510231.eng.abstr-s2-t2", "normalized": [] }, { "id": "DerHautarzt.00510231.eng.abstr-s2-r10-t1.1-t6.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510231.eng.abstr-s2-t1", "arg2_id": "DerHautarzt.00510231.eng.abstr-s2-t6", "normalized": [] }, { "id": "DerHautarzt.00510231.eng.abstr-s2-r11-t2.1-t6.1", "type": "location_of", "arg1_id": "DerHautarzt.00510231.eng.abstr-s2-t2", "arg2_id": "DerHautarzt.00510231.eng.abstr-s2-t6", "normalized": [] }, { "id": "DerHautarzt.00510231.eng.abstr-s2-r12-t6.1-t1.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510231.eng.abstr-s2-t6", "arg2_id": "DerHautarzt.00510231.eng.abstr-s2-t1", "normalized": [] }, { "id": "DerHautarzt.00510231.eng.abstr-s2-r13-t6.1-t5.1", "type": "occurs_in", "arg1_id": "DerHautarzt.00510231.eng.abstr-s2-t6", "arg2_id": "DerHautarzt.00510231.eng.abstr-s2-t5", "normalized": [] }, { "id": "DerHautarzt.00510231.eng.abstr-s2-r14-t1.1-t4.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510231.eng.abstr-s2-t1", "arg2_id": "DerHautarzt.00510231.eng.abstr-s2-t4", "normalized": [] }, { "id": "DerHautarzt.00510231.eng.abstr-s2-r15-t5.1-t1.1", "type": "performs", "arg1_id": "DerHautarzt.00510231.eng.abstr-s2-t5", "arg2_id": "DerHautarzt.00510231.eng.abstr-s2-t1", "normalized": [] } ]
DerHautarzt.00510239.eng.abstr	DerHautarzt.00510239.eng.abstr	[ { "id": "DerHautarzt.00510239.eng.abstr-passage-0", "type": "abstract", "text": [ "Background and objective . The Information Network of Departments of Dermatology ( IVDK ) centrally collects patch tests results in cooperation with the German Contact Dermatitis Research Group ( DKG ) . Data of patients , who underwent patch testing to evaluate otitis externa were analyzed ." ], "offsets": [ [ 0, 293 ] ] } ]	[ { "id": "DerHautarzt.00510239.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "objective" ], "offsets": [ [ 15, 24 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018017" } ] }, { "id": "DerHautarzt.00510239.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "Dermatology" ], "offsets": [ [ 69, 80 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011627" } ] }, { "id": "DerHautarzt.00510239.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "tests" ], "offsets": [ [ 115, 120 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0076174" } ] }, { "id": "DerHautarzt.00510239.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "Dermatitis" ], "offsets": [ [ 168, 178 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011603" } ] }, { "id": "DerHautarzt.00510239.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "Research" ], "offsets": [ [ 179, 187 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035168" } ] }, { "id": "DerHautarzt.00510239.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "Information Network" ], "offsets": [ [ 31, 50 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021419" } ] }, { "id": "DerHautarzt.00510239.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "patch tests" ], "offsets": [ [ 109, 120 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030646" } ] }, { "id": "DerHautarzt.00510239.eng.abstr-s2-t7", "type": "umlsterm", "text": [ "Contact Dermatitis" ], "offsets": [ [ 160, 178 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011616" } ] }, { "id": "DerHautarzt.00510239.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 212, 220 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510239.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "testing" ], "offsets": [ [ 243, 250 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039593" } ] }, { "id": "DerHautarzt.00510239.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "otitis" ], "offsets": [ [ 263, 269 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029877" } ] }, { "id": "DerHautarzt.00510239.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "otitis externa" ], "offsets": [ [ 263, 277 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029878" } ] } ]	[]	[]	[ { "id": "DerHautarzt.00510239.eng.abstr-s2-r1-t2.1-t7.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510239.eng.abstr-s3-t2", "arg2_id": "DerHautarzt.00510239.eng.abstr-s2-t7", "normalized": [] }, { "id": "DerHautarzt.00510239.eng.abstr-s2-r2-t4.1-t2.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510239.eng.abstr-s3-t4", "arg2_id": "DerHautarzt.00510239.eng.abstr-s3-t2", "normalized": [] }, { "id": "DerHautarzt.00510239.eng.abstr-s2-r3-t5.1-t7.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510239.eng.abstr-s2-t5", "arg2_id": "DerHautarzt.00510239.eng.abstr-s2-t7", "normalized": [] 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"DerHautarzt.00510239.eng.abstr-s2-t7", "arg2_id": "DerHautarzt.00510239.eng.abstr-s3-t4", "normalized": [] }, { "id": "DerHautarzt.00510239.eng.abstr-s2-r19-t2.1-t7.1", "type": "diagnoses", "arg1_id": "DerHautarzt.00510239.eng.abstr-s3-t2", "arg2_id": "DerHautarzt.00510239.eng.abstr-s2-t7", "normalized": [] }, { "id": "DerHautarzt.00510239.eng.abstr-s2-r20-t4.1-t1.1", "type": "method_of", "arg1_id": "DerHautarzt.00510239.eng.abstr-s3-t4", "arg2_id": "DerHautarzt.00510239.eng.abstr-s3-t1", "normalized": [] }, { "id": "DerHautarzt.00510239.eng.abstr-s2-r21-t2.1-t1.1", "type": "issue_in", "arg1_id": "DerHautarzt.00510239.eng.abstr-s3-t2", "arg2_id": "DerHautarzt.00510239.eng.abstr-s3-t1", "normalized": [] }, { "id": "DerHautarzt.00510239.eng.abstr-s3-r1-t4.1-t1.1", "type": "occurs_in", "arg1_id": "DerHautarzt.00510239.eng.abstr-s3-t4", "arg2_id": "DerHautarzt.00510239.eng.abstr-s3-t1", "normalized": [] }, { "id": "DerHautarzt.00510239.eng.abstr-s3-r2-t4.1-t2.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510239.eng.abstr-s3-t4", "arg2_id": "DerHautarzt.00510239.eng.abstr-s3-t2", "normalized": [] }, { "id": "DerHautarzt.00510239.eng.abstr-s3-r3-t1.1-t2.1", "type": "performs", "arg1_id": "DerHautarzt.00510239.eng.abstr-s3-t1", "arg2_id": "DerHautarzt.00510239.eng.abstr-s3-t2", "normalized": [] }, { "id": "DerHautarzt.00510239.eng.abstr-s3-r4-t2.1-t1.1", "type": "occurs_in", "arg1_id": "DerHautarzt.00510239.eng.abstr-s3-t2", "arg2_id": "DerHautarzt.00510239.eng.abstr-s3-t1", "normalized": [] }, { "id": "DerHautarzt.00510239.eng.abstr-s3-r5-t2.1-t4.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510239.eng.abstr-s3-t2", "arg2_id": "DerHautarzt.00510239.eng.abstr-s3-t4", "normalized": [] } ]
DerHautarzt.00510244.eng.abstr	DerHautarzt.00510244.eng.abstr	[ { "id": "DerHautarzt.00510244.eng.abstr-passage-0", "type": "abstract", "text": [ "Background and objective . In 1970 Ralph W. Grover described a clinicopathologic entity characterized by pruritic keratotic papules and papulovesicles predominantly on the trunk , disappearing spontaneously after a few weeks or months and demonstrating the histological features of epidermal acantholysis . The etiology remains unknown ; sweating , heat and sunlight are suspected trigger factors . In our survey the clinical spectrum of the disease will be examined ." ], "offsets": [ [ 0, 468 ] ] } ]	[ { "id": "DerHautarzt.00510244.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "objective" ], "offsets": [ [ 15, 24 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018017" } ] }, { "id": "DerHautarzt.00510244.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "acantholysis" ], "offsets": [ [ 292, 304 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000887" } ] }, { "id": "DerHautarzt.00510244.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "etiology" ], "offsets": [ [ 311, 319 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015127" }, { "db_name": "UMLS", "db_id": "C0007463" } ] }, { "id": "DerHautarzt.00510244.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "sweating" ], "offsets": [ [ 338, 346 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038990" }, { "db_name": "UMLS", "db_id": "C0038984" } ] }, { "id": "DerHautarzt.00510244.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "heat" ], "offsets": [ [ 349, 353 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018843" }, { "db_name": "UMLS", "db_id": "C0018837" } ] }, { "id": "DerHautarzt.00510244.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "sunlight" ], "offsets": [ [ 358, 366 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038817" } ] }, { "id": "DerHautarzt.00510244.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "trigger factors" ], "offsets": [ [ 381, 396 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0917961" } ] }, { "id": "DerHautarzt.00510244.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "survey" ], "offsets": [ [ 406, 412 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038951" } ] }, { "id": "DerHautarzt.00510244.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 442, 449 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] } ]	[]	[]	[ { "id": "DerHautarzt.00510244.eng.abstr-s3-r1-t5.1-t3.1", "type": "causes", "arg1_id": "DerHautarzt.00510244.eng.abstr-s3-t5", "arg2_id": "DerHautarzt.00510244.eng.abstr-s3-t3", "normalized": [] }, { "id": "DerHautarzt.00510244.eng.abstr-s3-r3-t4.1-t3.1", "type": "result_of", "arg1_id": "DerHautarzt.00510244.eng.abstr-s3-t4", "arg2_id": "DerHautarzt.00510244.eng.abstr-s3-t3", "normalized": [] }, { "id": "DerHautarzt.00510244.eng.abstr-s3-r5-t5.1-t3.1", "type": "complicates", "arg1_id": "DerHautarzt.00510244.eng.abstr-s3-t5", "arg2_id": "DerHautarzt.00510244.eng.abstr-s3-t3", "normalized": [] }, { "id": "DerHautarzt.00510244.eng.abstr-s3-r6-t3.1-t2.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510244.eng.abstr-s3-t3", "arg2_id": "DerHautarzt.00510244.eng.abstr-s4-t2", "normalized": [] }, { "id": "DerHautarzt.00510244.eng.abstr-s3-r7-t3.1-t4.1", "type": "result_of", "arg1_id": "DerHautarzt.00510244.eng.abstr-s3-t3", "arg2_id": "DerHautarzt.00510244.eng.abstr-s3-t4", "normalized": [] }, { "id": "DerHautarzt.00510244.eng.abstr-s3-r8-t5.1-t3.2", "type": "affects", "arg1_id": "DerHautarzt.00510244.eng.abstr-s3-t5", "arg2_id": "DerHautarzt.00510244.eng.abstr-s3-t3", "normalized": [] }, { "id": "DerHautarzt.00510244.eng.abstr-s3-r9-t2.1-t3.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510244.eng.abstr-s4-t2", "arg2_id": "DerHautarzt.00510244.eng.abstr-s3-t3", "normalized": [] }, { "id": "DerHautarzt.00510244.eng.abstr-s3-r10-t5.1-t4.1", "type": "affects", "arg1_id": "DerHautarzt.00510244.eng.abstr-s3-t5", "arg2_id": "DerHautarzt.00510244.eng.abstr-s3-t4", "normalized": [] }, { "id": "DerHautarzt.00510244.eng.abstr-s3-r11-t2.2-t3.1", "type": "causes", "arg1_id": "DerHautarzt.00510244.eng.abstr-s3-t2", "arg2_id": "DerHautarzt.00510244.eng.abstr-s3-t3", "normalized": [] }, { "id": "DerHautarzt.00510244.eng.abstr-s3-r12-t2.2-t5.1", "type": "consists_of", "arg1_id": "DerHautarzt.00510244.eng.abstr-s3-t2", "arg2_id": "DerHautarzt.00510244.eng.abstr-s3-t5", "normalized": [] } ]
DerHautarzt.00510256.eng.abstr	DerHautarzt.00510256.eng.abstr	[ { "id": "DerHautarzt.00510256.eng.abstr-passage-0", "type": "abstract", "text": [ "Both herpes simplex and herpes zoster are not uncommon in patients affected by malignant lymphoma or leukemia . Of particular interest , the herpetic lesions may be followed by specific cutaneous infiltrates . We report on a patient with a centrocytic-centroblastic non-Hodgkin lymphoma who showed primary skin infiltrates within the area affected by herpes simplex . After effective therapy with aciclovir , papules and plaques developed at the site of the herpetic scars . Histologic investigation confirmed dense B-lymphocytic infiltrates with immunoglobulin light chain restriction and a granulomatous reaction . Although the chemotherapeutical regiment was modified , the patient died one month later of a lethal blast crisis . The occurrence of so called isotopic skin reactions and their prognostic significance is discussed ." ], "offsets": [ [ 0, 833 ] ] } ]	[ { "id": "DerHautarzt.00510256.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "herpes" ], "offsets": [ [ 5, 11 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019369" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "simplex" ], "offsets": [ [ 12, 19 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0142328" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "herpes" ], "offsets": [ [ 24, 30 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019369" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "zoster" ], "offsets": [ [ 31, 37 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019360" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 58, 66 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "malignant" ], "offsets": [ [ 79, 88 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006826" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "lymphoma" ], "offsets": [ [ 89, 97 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024299" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "leukemia" ], "offsets": [ [ 101, 109 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023418" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s1-t9", "type": "umlsterm", "text": [ "herpes simplex" ], "offsets": [ [ 5, 19 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019348" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s1-t10", "type": "umlsterm", "text": [ "herpes zoster" ], "offsets": [ [ 24, 37 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019360" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s1-t11", "type": "umlsterm", "text": [ "malignant lymphoma" ], "offsets": [ [ 79, 97 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024299" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 225, 232 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "lymphoma" ], "offsets": [ [ 278, 286 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024299" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "skin" ], "offsets": [ [ 306, 310 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "herpes" ], "offsets": [ [ 351, 357 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019369" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "simplex" ], "offsets": [ [ 358, 365 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0142328" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "non-Hodgkin lymphoma" ], "offsets": [ [ 266, 286 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024305" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s3-t7", "type": "umlsterm", "text": [ "herpes simplex" ], "offsets": [ [ 351, 365 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019348" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 384, 391 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "aciclovir" ], "offsets": [ [ 397, 406 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001367" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "plaques" ], "offsets": [ [ 421, 428 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011389" }, { "db_name": "UMLS", "db_id": "C0333463" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "scars" ], "offsets": [ [ 467, 472 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008767" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "Histologic" ], "offsets": [ [ 475, 485 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0205462" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "immunoglobulin" ], "offsets": [ [ 547, 561 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021027" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "light" ], "offsets": [ [ 562, 567 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023693" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "immunoglobulin light chain" ], "offsets": [ [ 547, 573 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021038" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "chemotherapeutical" ], "offsets": [ [ 630, 648 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032636" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 677, 684 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "patient died" ], "offsets": [ [ 677, 689 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011065" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "blast crisis" ], "offsets": [ [ 718, 730 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005699" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "occurrence" ], "offsets": [ [ 737, 747 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243132" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s7-t2", "type": "umlsterm", "text": [ "skin" ], "offsets": [ [ 770, 774 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] } ]	[]	[]	[ { "id": "DerHautarzt.00510256.eng.abstr-s1-r1-t2.1-t4.1", "type": "affects", "arg1_id": "DerHautarzt.00510256.eng.abstr-s7-t2", "arg2_id": "DerHautarzt.00510256.eng.abstr-s6-t4", "normalized": [] }, { "id": "DerHautarzt.00510256.eng.abstr-s1-r2-t2.1-t4.1", "type": "causes", "arg1_id": "DerHautarzt.00510256.eng.abstr-s7-t2", "arg2_id": "DerHautarzt.00510256.eng.abstr-s6-t4", "normalized": [] }, { "id": "DerHautarzt.00510256.eng.abstr-s1-r3-t1.1-t11.1", "type": "causes", "arg1_id": "DerHautarzt.00510256.eng.abstr-s7-t1", "arg2_id": "DerHautarzt.00510256.eng.abstr-s1-t11", "normalized": [] }, { "id": "DerHautarzt.00510256.eng.abstr-s1-r4-t4.1-t11.1", "type": "degree_of", "arg1_id": "DerHautarzt.00510256.eng.abstr-s6-t4", "arg2_id": "DerHautarzt.00510256.eng.abstr-s1-t11", "normalized": [] }, { "id": "DerHautarzt.00510256.eng.abstr-s1-r5-t4.1-t6.1", "type": "degree_of", "arg1_id": "DerHautarzt.00510256.eng.abstr-s6-t4", "arg2_id": "DerHautarzt.00510256.eng.abstr-s3-t6", "normalized": [] }, { "id": "DerHautarzt.00510256.eng.abstr-s1-r6-t2.1-t11.1", "type": "causes", "arg1_id": "DerHautarzt.00510256.eng.abstr-s7-t2", "arg2_id": "DerHautarzt.00510256.eng.abstr-s1-t11", "normalized": [] }, { "id": "DerHautarzt.00510256.eng.abstr-s1-r7-t2.1-t9.1", "type": "affects", "arg1_id": "DerHautarzt.00510256.eng.abstr-s7-t2", "arg2_id": "DerHautarzt.00510256.eng.abstr-s1-t9", "normalized": [] }, { "id": "DerHautarzt.00510256.eng.abstr-s1-r8-t10.1-t2.1", "type": "affects", "arg1_id": "DerHautarzt.00510256.eng.abstr-s1-t10", "arg2_id": "DerHautarzt.00510256.eng.abstr-s7-t2", "normalized": [] }, { "id": "DerHautarzt.00510256.eng.abstr-s1-r9-t1.1-t8.1", "type": "causes", "arg1_id": "DerHautarzt.00510256.eng.abstr-s7-t1", "arg2_id": "DerHautarzt.00510256.eng.abstr-s1-t8", 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DerHautarzt.00510264.eng.abstr	DerHautarzt.00510264.eng.abstr	[ { "id": "DerHautarzt.00510264.eng.abstr-passage-0", "type": "abstract", "text": [ "We report a woman with erythema palmare hereditarium , an anomaly not documented so far in the German literature . It is characterized by a bright erythema of the palms , usually persistent since birth . It is transmitted in an autosomal-recessive mode and has a benign course . In our patient it was possible to trace the palmar erythema over three generations ." ], "offsets": [ [ 0, 363 ] ] } ]	[ { "id": "DerHautarzt.00510264.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "woman" ], "offsets": [ [ 12, 17 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043210" } ] }, { "id": "DerHautarzt.00510264.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "erythema" ], "offsets": [ [ 23, 31 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0041834" } ] }, { "id": "DerHautarzt.00510264.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "anomaly" ], "offsets": [ [ 58, 65 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000769" } ] }, { "id": "DerHautarzt.00510264.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "literature" ], "offsets": [ [ 102, 112 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023866" } ] }, { "id": "DerHautarzt.00510264.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "erythema" ], "offsets": [ [ 147, 155 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0041834" } ] }, { "id": "DerHautarzt.00510264.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "birth" ], "offsets": [ [ 196, 201 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005615" } ] }, { "id": "DerHautarzt.00510264.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 286, 293 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510264.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "erythema" ], "offsets": [ [ 330, 338 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0041834" } ] }, { "id": "DerHautarzt.00510264.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "generations" ], "offsets": [ [ 350, 361 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0079411" } ] } ]	[]	[]	[ { "id": "DerHautarzt.00510264.eng.abstr-s1-r1-t1.1-t3.1", "type": "uses", "arg1_id": "DerHautarzt.00510264.eng.abstr-s4-t1", "arg2_id": "DerHautarzt.00510264.eng.abstr-s4-t3", "normalized": [] }, { "id": "DerHautarzt.00510264.eng.abstr-s1-r2-t2.1-t1.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510264.eng.abstr-s4-t2", "arg2_id": "DerHautarzt.00510264.eng.abstr-s4-t1", "normalized": [] }, { "id": "DerHautarzt.00510264.eng.abstr-s1-r3-t1.1-t2.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510264.eng.abstr-s4-t1", "arg2_id": "DerHautarzt.00510264.eng.abstr-s4-t2", "normalized": [] }, { "id": "DerHautarzt.00510264.eng.abstr-s2-r1-t2.1-t1.1", "type": "result_of", "arg1_id": "DerHautarzt.00510264.eng.abstr-s4-t2", "arg2_id": "DerHautarzt.00510264.eng.abstr-s4-t1", "normalized": [] }, { "id": "DerHautarzt.00510264.eng.abstr-s2-r2-t1.1-t2.1", "type": "result_of", "arg1_id": "DerHautarzt.00510264.eng.abstr-s4-t1", "arg2_id": "DerHautarzt.00510264.eng.abstr-s4-t2", "normalized": [] }, { "id": "DerHautarzt.00510264.eng.abstr-s2-r3-t1.1-t2.1", "type": "evaluation_of", "arg1_id": "DerHautarzt.00510264.eng.abstr-s4-t1", "arg2_id": "DerHautarzt.00510264.eng.abstr-s4-t2", "normalized": [] }, { "id": "DerHautarzt.00510264.eng.abstr-s4-r1-t2.1-t1.1", "type": "occurs_in", "arg1_id": "DerHautarzt.00510264.eng.abstr-s4-t2", "arg2_id": "DerHautarzt.00510264.eng.abstr-s4-t1", "normalized": [] } ]
DerHautarzt.00510266.eng.abstr	DerHautarzt.00510266.eng.abstr	[ { "id": "DerHautarzt.00510266.eng.abstr-passage-0", "type": "abstract", "text": [ "We report on a child with pili trianguli et canaliculi . This hair shaft abnormality belongs to a heterogeneous group of diseases which are included under the synonym uncombable hair . The diagnosis was confirmed by scanning electron microscopy , revealing hair shafts with a characteristic longitudinal groove . In addition the girl suffered from atopic eczema and tooth anomalies . Our findings suggest that this disorder could represent a tricho-odontal subtype of ectodermal dysplasia ." ], "offsets": [ [ 0, 490 ] ] } ]	[ { "id": "DerHautarzt.00510266.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "child" ], "offsets": [ [ 15, 20 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008059" } ] }, { "id": "DerHautarzt.00510266.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "hair" ], "offsets": [ [ 62, 66 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018494" } ] }, { "id": "DerHautarzt.00510266.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "abnormality" ], "offsets": [ [ 73, 84 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000768" }, { "db_name": "UMLS", "db_id": "C0000769" } ] }, { "id": "DerHautarzt.00510266.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "diseases" ], "offsets": [ [ 121, 129 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510266.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "hair" ], "offsets": [ [ 178, 182 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018494" } ] }, { "id": "DerHautarzt.00510266.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "diagnosis" ], "offsets": [ [ 189, 198 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011900" }, { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerHautarzt.00510266.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "electron" ], "offsets": [ [ 225, 233 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013852" } ] }, { "id": "DerHautarzt.00510266.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "microscopy" ], "offsets": [ [ 234, 244 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026018" } ] }, { "id": "DerHautarzt.00510266.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "hair" ], "offsets": [ [ 257, 261 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018494" } ] }, { "id": "DerHautarzt.00510266.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "electron microscopy" ], "offsets": [ [ 225, 244 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026019" } ] }, { "id": "DerHautarzt.00510266.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "scanning electron microscopy" ], "offsets": [ [ 216, 244 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026020" } ] }, { "id": "DerHautarzt.00510266.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "eczema" ], "offsets": [ [ 355, 361 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013595" } ] }, { "id": "DerHautarzt.00510266.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "tooth" ], "offsets": [ [ 366, 371 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040426" } ] }, { "id": "DerHautarzt.00510266.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "anomalies" ], "offsets": [ [ 372, 381 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000769" } ] }, { "id": "DerHautarzt.00510266.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "atopic eczema" ], "offsets": [ [ 348, 361 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011615" } ] }, { "id": "DerHautarzt.00510266.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "findings" ], "offsets": [ [ 388, 396 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243095" } ] }, { "id": "DerHautarzt.00510266.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "disorder" ], "offsets": [ [ 415, 423 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510266.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "ectodermal dysplasia" ], "offsets": [ [ 468, 488 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013575" } ] } ]	[]	[]	[ { "id": "DerHautarzt.00510266.eng.abstr-s2-r1-t2.2-t1.1", "type": "produces", "arg1_id": "DerHautarzt.00510266.eng.abstr-s2-t2", "arg2_id": "DerHautarzt.00510266.eng.abstr-s5-t1", "normalized": [] }, { "id": "DerHautarzt.00510266.eng.abstr-s2-r2-t1.1-t2.1", "type": "causes", "arg1_id": "DerHautarzt.00510266.eng.abstr-s5-t1", "arg2_id": "DerHautarzt.00510266.eng.abstr-s5-t2", "normalized": [] }, 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DerHautarzt.00510270.eng.abstr	DerHautarzt.00510270.eng.abstr	[ { "id": "DerHautarzt.00510270.eng.abstr-passage-0", "type": "abstract", "text": [ "Annular erythema has been recognised as a cutaneous manifestation of Sjoegren's syndrome in the Asian literature and has been assumed to represent a distinct clinical entity . Since there are common pathophysiologic mechanisms , mainly the presence of anti-Ro/SSA or anti-La/SSB antibodies , it is difficult to separate the annular erythema from subacute cutaneous lupus erythematosus . Histological examination may reveal dermal mucin deposition resembling lupus erythematosus tumidus . We present a Chinese patient with widespread annular erythema , keratoconjunctivitis sicca , and anti-Ro/SSA antibodies . Clinical , histopathological , and immunogenetic findings are discussed reviewing the current literature , and the differences between annular erythema associated with Sjoegren's syndrome and cutaneous lupus erythematosus are emphasized ." ], "offsets": [ [ 0, 848 ] ] } ]	[ { "id": "DerHautarzt.00510270.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "erythema" ], "offsets": [ [ 8, 16 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0041834" } ] }, { "id": "DerHautarzt.00510270.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "syndrome" ], "offsets": [ [ 80, 88 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "DerHautarzt.00510270.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "Asian" ], "offsets": [ [ 96, 101 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0078988" } ] }, { "id": "DerHautarzt.00510270.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "literature" ], "offsets": [ [ 102, 112 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023866" } ] }, { "id": "DerHautarzt.00510270.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "antibodies" ], "offsets": [ [ 279, 289 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003241" } ] }, { "id": "DerHautarzt.00510270.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "erythema" ], "offsets": [ [ 332, 340 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0041834" } ] }, { "id": "DerHautarzt.00510270.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "lupus" ], "offsets": [ [ 365, 370 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024138" }, { "db_name": "UMLS", "db_id": "C0024131" }, { "db_name": "UMLS", "db_id": "C0024141" } ] }, { "id": "DerHautarzt.00510270.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "erythematosus" ], "offsets": [ [ 371, 384 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0041834" } ] }, { "id": "DerHautarzt.00510270.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "mucin" ], "offsets": [ [ 430, 435 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026682" } ] }, { "id": "DerHautarzt.00510270.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "lupus" ], "offsets": [ [ 458, 463 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024138" }, { "db_name": "UMLS", "db_id": "C0024131" }, { "db_name": "UMLS", "db_id": "C0024141" } ] }, { "id": "DerHautarzt.00510270.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "erythematosus" ], "offsets": [ [ 464, 477 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0041834" } ] }, { "id": "DerHautarzt.00510270.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "Chinese" ], "offsets": [ [ 501, 508 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0152035" } ] }, { "id": "DerHautarzt.00510270.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 509, 516 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510270.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "erythema" ], "offsets": [ [ 541, 549 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0041834" } ] }, { "id": "DerHautarzt.00510270.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "keratoconjunctivitis" ], "offsets": [ [ 552, 572 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022573" } ] }, { "id": "DerHautarzt.00510270.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "antibodies" ], "offsets": [ [ 597, 607 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003241" } ] }, { "id": "DerHautarzt.00510270.eng.abstr-s4-t6", "type": "umlsterm", "text": [ "keratoconjunctivitis sicca" ], "offsets": [ [ 552, 578 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022575" } ] }, { "id": "DerHautarzt.00510270.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "histopathological" ], "offsets": [ [ 621, 638 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243140" } ] }, { "id": "DerHautarzt.00510270.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "immunogenetic" ], "offsets": [ [ 645, 658 ] ], "normalized": [ { "db_name": "UMLS", "db_id": 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DerHautarzt.00510299.eng.abstr	DerHautarzt.00510299.eng.abstr	[ { "id": "DerHautarzt.00510299.eng.abstr-passage-0", "type": "abstract", "text": [ "With the help of the German Ministry of Health and the health insurance companies a national interdisciplinary project for children and adolescents with atopic eczema will be developed . The aim of the project is to generate standardized teaching concepts for parents and children covering medical , psychological and social aspect of the disease . 800 children and adolescents of different age groups will be enrolled in this poject . Furthermore , during the three years of the study the efficacy of the teaching concept will be evaluated ." ], "offsets": [ [ 0, 542 ] ] } ]	[ { "id": "DerHautarzt.00510299.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Health" ], "offsets": [ [ 40, 46 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018684" } ] }, { "id": "DerHautarzt.00510299.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "health" ], "offsets": [ [ 55, 61 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018684" } ] }, { "id": "DerHautarzt.00510299.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "insurance" ], "offsets": [ [ 62, 71 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021672" } ] }, { "id": "DerHautarzt.00510299.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "national" ], "offsets": [ [ 84, 92 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015737" } ] }, { "id": "DerHautarzt.00510299.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "children" ], "offsets": [ [ 123, 131 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008059" } ] }, { "id": "DerHautarzt.00510299.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "adolescents" ], "offsets": [ [ 136, 147 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001587" } ] }, { "id": "DerHautarzt.00510299.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "eczema" ], "offsets": [ [ 160, 166 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013595" } ] }, { "id": "DerHautarzt.00510299.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "health insurance" ], "offsets": [ [ 55, 71 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021682" } ] }, { "id": "DerHautarzt.00510299.eng.abstr-s1-t9", "type": "umlsterm", "text": [ "atopic eczema" ], "offsets": [ [ 153, 166 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011615" } ] }, { "id": "DerHautarzt.00510299.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "aim" ], "offsets": [ [ 191, 194 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0108800" } ] }, { "id": "DerHautarzt.00510299.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "teaching" ], "offsets": [ [ 238, 246 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039401" }, { "db_name": "UMLS", "db_id": "C0220924" } ] }, { "id": "DerHautarzt.00510299.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "parents" ], "offsets": [ [ 260, 267 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030551" } ] }, { "id": "DerHautarzt.00510299.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "children" ], "offsets": [ [ 272, 280 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008059" } ] }, { "id": "DerHautarzt.00510299.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 339, 346 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510299.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "children" ], "offsets": [ [ 353, 361 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008059" } ] }, { "id": "DerHautarzt.00510299.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "adolescents" ], "offsets": [ [ 366, 377 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001587" } ] }, { "id": "DerHautarzt.00510299.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "age" ], "offsets": [ [ 391, 394 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001792" }, { "db_name": "UMLS", "db_id": "C0001811" } ] }, { "id": "DerHautarzt.00510299.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "age groups" ], "offsets": [ [ 391, 401 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027362" } ] }, { "id": "DerHautarzt.00510299.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "teaching" ], "offsets": [ [ 506, 514 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039401" }, { "db_name": "UMLS", "db_id": "C0220924" } ] } ]	[]	[]	[ { "id": "DerHautarzt.00510299.eng.abstr-s1-r1-t9.1-t6.1", "type": "occurs_in", "arg1_id": "DerHautarzt.00510299.eng.abstr-s1-t9", "arg2_id": 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DerHautarzt.00510302.eng.abstr	DerHautarzt.00510302.eng.abstr	[ { "id": "DerHautarzt.00510302.eng.abstr-passage-0", "type": "abstract", "text": [ "Although the etiology of urticaria is mostly unclear , there are a number of recent new insights into the underlying pathomechanisms and causes . Dermal mast cell numbers and endothelial cell adhesion molecule and cytokine expression are also increased in uninvolved skin , while serum P-selectin levels are elevated , suggesting a systemic activation of the cutaneous inflammatory system in urticaria . In all adults , but not children with indolent mastocytosis , we found activating point mutations of c-kit , the mast cell growth factor receptor , in lesional cutaneous mast cells . In acute urticaria , IgE-dependent mechanisms are only rarely involved ( 0.9% ) , in contrast to generally held beliefs , whereas acute upper respiratory infections ( 39.3% ) and drug intolerance ( 9.2% ) are more frequent . In chronic urticaria , pseudoallergies to food ( 73% ) and more rarely chronic inflammatory gastrointestinal diseases ( 11% ) play a major role , with avoidance or elimination of the eliciting factors leading to long term remission . On the basis of recent findings , autoantibodies must be viewed mostly as secondary rather than causative in chronic urticaria ." ], "offsets": [ [ 0, 1174 ] ] } ]	[ { "id": "DerHautarzt.00510302.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "etiology" ], "offsets": [ [ 13, 21 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015127" }, { "db_name": "UMLS", "db_id": "C0007463" } ] }, { "id": "DerHautarzt.00510302.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "urticaria" ], "offsets": [ [ 25, 34 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042109" } ] }, { "id": "DerHautarzt.00510302.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "causes" ], "offsets": [ [ 137, 143 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015127" } ] }, { "id": "DerHautarzt.00510302.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "mast" ], "offsets": [ [ 153, 157 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242302" } ] }, { "id": "DerHautarzt.00510302.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "cell" ], "offsets": [ [ 158, 162 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "DerHautarzt.00510302.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "cell" ], "offsets": [ [ 187, 191 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "DerHautarzt.00510302.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "adhesion" ], "offsets": [ [ 192, 200 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001511" } ] }, { "id": "DerHautarzt.00510302.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "cytokine" ], "offsets": [ [ 214, 222 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0079189" } ] }, { "id": "DerHautarzt.00510302.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "skin" ], "offsets": [ [ 267, 271 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] }, { "id": "DerHautarzt.00510302.eng.abstr-s2-t7", "type": "umlsterm", "text": [ "P-selectin" ], "offsets": [ [ 286, 296 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0134835" } ] }, { "id": "DerHautarzt.00510302.eng.abstr-s2-t8", "type": "umlsterm", "text": [ "urticaria" ], "offsets": [ [ 392, 401 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042109" } ] }, { "id": "DerHautarzt.00510302.eng.abstr-s2-t9", "type": "umlsterm", "text": [ "mast cell" ], "offsets": [ [ 153, 162 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024880" } ] }, { "id": "DerHautarzt.00510302.eng.abstr-s2-t10", "type": "umlsterm", "text": [ "cell adhesion" ], "offsets": [ [ 187, 200 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007577" } ] }, { "id": "DerHautarzt.00510302.eng.abstr-s2-t11", "type": "umlsterm", "text": [ "adhesion molecule" ], "offsets": [ [ 192, 209 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007578" } ] }, { "id": "DerHautarzt.00510302.eng.abstr-s2-t12", "type": "umlsterm", "text": [ "cell adhesion molecule" ], "offsets": [ [ 187, 209 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007578" } ] 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"text": [ "cell" ], "offsets": [ [ 522, 526 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "DerHautarzt.00510302.eng.abstr-s3-t7", "type": "umlsterm", "text": [ "growth" ], "offsets": [ [ 527, 533 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018270" }, { "db_name": "UMLS", "db_id": "C0220844" } ] }, { "id": "DerHautarzt.00510302.eng.abstr-s3-t8", "type": "umlsterm", "text": [ "mast" ], "offsets": [ [ 574, 578 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242302" } ] }, { "id": "DerHautarzt.00510302.eng.abstr-s3-t9", "type": "umlsterm", "text": [ "cells" ], "offsets": [ [ 579, 584 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "DerHautarzt.00510302.eng.abstr-s3-t10", "type": "umlsterm", "text": [ "point mutations" ], "offsets": [ [ 486, 501 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162735" } ] }, { "id": "DerHautarzt.00510302.eng.abstr-s3-t11", "type": "umlsterm", "text": [ "mast cell" ], "offsets": 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"UMLS", "db_id": "C0042109" } ] }, { "id": "DerHautarzt.00510302.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "contrast" ], "offsets": [ [ 672, 680 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0110625" } ] }, { "id": "DerHautarzt.00510302.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "beliefs" ], "offsets": [ [ 699, 706 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004951" } ] }, { "id": "DerHautarzt.00510302.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "infections" ], "offsets": [ [ 741, 751 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021311" } ] }, { "id": "DerHautarzt.00510302.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "drug" ], "offsets": [ [ 766, 770 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013227" } ] }, { "id": "DerHautarzt.00510302.eng.abstr-s4-t6", "type": "umlsterm", "text": [ "respiratory infections" ], "offsets": [ [ 729, 751 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035243" } ] }, { "id": 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DerHautarzt.00510309.eng.abstr	DerHautarzt.00510309.eng.abstr	[ { "id": "DerHautarzt.00510309.eng.abstr-passage-0", "type": "abstract", "text": [ "Pemphigus diseases comprise a group of autoimmune disorders which are characterized by intraepidermal blisters and autoantibodies to components of desmosomes . Desmosomes mediate adhesion between neighbouring keratinocytes . A common feature of pemphigus diseases are intercellular deposits of IgG or , less frequently , of IgA within the epidermis . The group of pemphigus diseases includes pemphigus vulgaris , pemphigus foliaceus , pemphigus vegetans , pemphigus herpetiformis , pemphigus erythematosus , paraneoplastic pemphigus , drug-induced pemphigus , and IgA pemphigus . Using molecular tools , some of the autoantigens in these diseases have been characterized . In pemphigus vulgaris , autoantibodies are directed to desmoglein 3 and in pemphigus foliaceus to desmoglein 1. Target antigens in IgA pemphigus are desmocollin 1 and desmoglein 3. In paraneoplastic pemphigus , autoantibodies react with a complex of various proteins , including desmoplakin 1 and 2 , BP230, envoplakin , periplakin , plectin , desmoglein 3 , and a yet uncharacterized 170 kD protein . This review summarizes new insights into the immunopathogenesis and diagnosis of pemphigus diseases ." ], "offsets": [ [ 0, 1176 ] ] } ]	[ { "id": "DerHautarzt.00510309.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Pemphigus" ], "offsets": [ [ 0, 9 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030807" } ] }, { "id": "DerHautarzt.00510309.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "diseases" ], "offsets": [ [ 10, 18 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510309.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "disorders" ], "offsets": [ [ 50, 59 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510309.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "blisters" ], "offsets": [ [ 102, 110 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005758" } ] }, { "id": "DerHautarzt.00510309.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "autoantibodies" ], "offsets": [ [ 115, 129 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004358" } ] }, { "id": "DerHautarzt.00510309.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "desmosomes" ], "offsets": [ [ 147, 157 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011703" } ] }, { "id": "DerHautarzt.00510309.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "autoimmune disorders" ], "offsets": [ [ 39, 59 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004364" } ] }, { "id": "DerHautarzt.00510309.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "Desmosomes" ], "offsets": [ [ 160, 170 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011703" } ] }, { "id": "DerHautarzt.00510309.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "adhesion" ], "offsets": [ [ 179, 187 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001511" } ] }, { "id": "DerHautarzt.00510309.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "keratinocytes" ], "offsets": [ [ 209, 222 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022567" } ] }, { "id": "DerHautarzt.00510309.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "pemphigus" ], "offsets": [ [ 245, 254 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030807" } ] }, { "id": "DerHautarzt.00510309.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "diseases" ], "offsets": [ [ 255, 263 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510309.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "IgG" ], "offsets": [ [ 294, 297 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020852" } ] }, { "id": "DerHautarzt.00510309.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "IgA" ], "offsets": [ [ 324, 327 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020835" } ] }, { "id": "DerHautarzt.00510309.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "epidermis" ], "offsets": [ [ 339, 348 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014520" } ] }, { "id": "DerHautarzt.00510309.eng.abstr-s4-t1", "type": "umlsterm", "text": 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DerHautarzt.00510319.eng.abstr	DerHautarzt.00510319.eng.abstr	[ { "id": "DerHautarzt.00510319.eng.abstr-passage-0", "type": "abstract", "text": [ "Background and Objective . For rational therapeutic recommendations the spectrum and resistance of bacteria in skin diseases were investigated ." ], "offsets": [ [ 0, 144 ] ] } ]	[ { "id": "DerHautarzt.00510319.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Objective" ], "offsets": [ [ 15, 24 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018017" } ] }, { "id": "DerHautarzt.00510319.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "therapeutic" ], "offsets": [ [ 40, 51 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "DerHautarzt.00510319.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "recommendations" ], "offsets": [ [ 52, 67 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034866" } ] }, { "id": "DerHautarzt.00510319.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "bacteria" ], "offsets": [ [ 99, 107 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004611" }, { "db_name": "UMLS", "db_id": "C0521009" } ] }, { "id": "DerHautarzt.00510319.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "skin" ], "offsets": [ [ 111, 115 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] }, { "id": "DerHautarzt.00510319.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "diseases" ], "offsets": [ [ 116, 124 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510319.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "skin diseases" ], "offsets": [ [ 111, 124 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037274" } ] } ]	[]	[]	[ { "id": "DerHautarzt.00510319.eng.abstr-s2-r1-t6.1-t2.1", "type": "affects", "arg1_id": "DerHautarzt.00510319.eng.abstr-s2-t6", "arg2_id": "DerHautarzt.00510319.eng.abstr-s2-t2", "normalized": [] }, { "id": "DerHautarzt.00510319.eng.abstr-s2-r2-t5.1-t3.2", "type": "associated_with", "arg1_id": "DerHautarzt.00510319.eng.abstr-s2-t5", "arg2_id": "DerHautarzt.00510319.eng.abstr-s2-t3", "normalized": [] }, { "id": "DerHautarzt.00510319.eng.abstr-s2-r3-t2.1-t6.1", "type": "causes", 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"type": "location_of", "arg1_id": "DerHautarzt.00510319.eng.abstr-s2-t3", "arg2_id": "DerHautarzt.00510319.eng.abstr-s2-t6", "normalized": [] }, { "id": "DerHautarzt.00510319.eng.abstr-s2-r9-t2.1-t5.1", "type": "causes", "arg1_id": "DerHautarzt.00510319.eng.abstr-s2-t2", "arg2_id": "DerHautarzt.00510319.eng.abstr-s2-t5", "normalized": [] }, { "id": "DerHautarzt.00510319.eng.abstr-s2-r10-t3.2-t6.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510319.eng.abstr-s2-t3", "arg2_id": "DerHautarzt.00510319.eng.abstr-s2-t6", "normalized": [] }, { "id": "DerHautarzt.00510319.eng.abstr-s2-r11-t1.1-t6.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510319.eng.abstr-s2-t1", "arg2_id": "DerHautarzt.00510319.eng.abstr-s2-t6", "normalized": [] }, { "id": "DerHautarzt.00510319.eng.abstr-s2-r12-t3.2-t5.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510319.eng.abstr-s2-t3", "arg2_id": "DerHautarzt.00510319.eng.abstr-s2-t5", "normalized": [] }, { "id": "DerHautarzt.00510319.eng.abstr-s2-r13-t6.1-t1.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510319.eng.abstr-s2-t6", "arg2_id": "DerHautarzt.00510319.eng.abstr-s2-t1", "normalized": [] }, { "id": "DerHautarzt.00510319.eng.abstr-s2-r14-t1.1-t5.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510319.eng.abstr-s2-t1", "arg2_id": "DerHautarzt.00510319.eng.abstr-s2-t5", "normalized": [] }, { "id": "DerHautarzt.00510319.eng.abstr-s2-r15-t3.2-t2.1", "type": "isa", "arg1_id": "DerHautarzt.00510319.eng.abstr-s2-t3", "arg2_id": "DerHautarzt.00510319.eng.abstr-s2-t2", "normalized": [] }, { "id": "DerHautarzt.00510319.eng.abstr-s2-r16-t3.2-t5.1", "type": "location_of", "arg1_id": "DerHautarzt.00510319.eng.abstr-s2-t3", "arg2_id": "DerHautarzt.00510319.eng.abstr-s2-t5", "normalized": [] }, { "id": "DerHautarzt.00510319.eng.abstr-s2-r17-t3.2-t2.1", "type": "property_of", "arg1_id": "DerHautarzt.00510319.eng.abstr-s2-t3", "arg2_id": "DerHautarzt.00510319.eng.abstr-s2-t2", "normalized": [] }, { "id": "DerHautarzt.00510319.eng.abstr-s2-r18-t5.1-t2.1", "type": "affects", "arg1_id": "DerHautarzt.00510319.eng.abstr-s2-t5", "arg2_id": "DerHautarzt.00510319.eng.abstr-s2-t2", "normalized": [] } ]
DerHautarzt.00510332.eng.abstr	DerHautarzt.00510332.eng.abstr	[ { "id": "DerHautarzt.00510332.eng.abstr-passage-0", "type": "abstract", "text": [ "The most common cause of acral cyanosis is vascular spasm which can be induced by several drugs . An 87-year-old woman developed red and livid skin lesions on the fingers of both hands and several toes one month after beginning treatment with quinine sulfate 200 mg daily . The skin lesions progressed to necrosis in some areas ." ], "offsets": [ [ 0, 329 ] ] } ]	[ { "id": "DerHautarzt.00510332.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "cause" ], "offsets": [ [ 16, 21 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015127" } ] }, { "id": "DerHautarzt.00510332.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "cyanosis" ], "offsets": [ [ 31, 39 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010520" } ] }, { "id": "DerHautarzt.00510332.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "spasm" ], "offsets": [ [ 52, 57 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037763" } ] }, { "id": "DerHautarzt.00510332.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "drugs" ], "offsets": [ [ 90, 95 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013227" } ] }, { "id": "DerHautarzt.00510332.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "woman" ], "offsets": [ [ 113, 118 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043210" } ] }, { "id": "DerHautarzt.00510332.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "skin" ], "offsets": [ [ 143, 147 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] }, { "id": "DerHautarzt.00510332.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "fingers" ], "offsets": [ [ 163, 170 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016129" } ] }, { "id": "DerHautarzt.00510332.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "hands" ], "offsets": [ [ 179, 184 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018563" } ] }, { "id": "DerHautarzt.00510332.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "toes" ], "offsets": [ [ 197, 201 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040357" } ] }, { "id": "DerHautarzt.00510332.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 228, 237 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerHautarzt.00510332.eng.abstr-s2-t7", "type": "umlsterm", "text": [ "quinine" ], "offsets": [ [ 243, 250 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034417" } ] }, { "id": "DerHautarzt.00510332.eng.abstr-s2-t8", "type": "umlsterm", "text": [ "quinine sulfate" ], "offsets": [ [ 243, 258 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034422" } ] }, { "id": "DerHautarzt.00510332.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "skin" ], "offsets": [ [ 278, 282 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] }, { "id": "DerHautarzt.00510332.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "necrosis" ], "offsets": [ [ 305, 313 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027540" } ] } ]	[]	[]	[ { "id": "DerHautarzt.00510332.eng.abstr-s1-r1-t4.1-t3.1", "type": "treats", "arg1_id": "DerHautarzt.00510332.eng.abstr-s2-t4", "arg2_id": "DerHautarzt.00510332.eng.abstr-s2-t3", "normalized": [] }, { "id": "DerHautarzt.00510332.eng.abstr-s1-r2-t4.1-t1.1", "type": "treats", "arg1_id": "DerHautarzt.00510332.eng.abstr-s2-t4", "arg2_id": "DerHautarzt.00510332.eng.abstr-s3-t1", "normalized": [] }, { "id": "DerHautarzt.00510332.eng.abstr-s2-r1-t3.1-t2.1", "type": "conceptual_part_of", "arg1_id": "DerHautarzt.00510332.eng.abstr-s2-t3", "arg2_id": "DerHautarzt.00510332.eng.abstr-s3-t2", "normalized": [] }, { "id": "DerHautarzt.00510332.eng.abstr-s2-r2-t6.1-t4.1", "type": "disrupts", "arg1_id": "DerHautarzt.00510332.eng.abstr-s2-t6", "arg2_id": "DerHautarzt.00510332.eng.abstr-s2-t4", "normalized": [] }, { "id": "DerHautarzt.00510332.eng.abstr-s2-r3-t2.1-t6.1", "type": "location_of", "arg1_id": "DerHautarzt.00510332.eng.abstr-s3-t2", "arg2_id": "DerHautarzt.00510332.eng.abstr-s2-t6", "normalized": [] }, { "id": "DerHautarzt.00510332.eng.abstr-s2-r4-t2.1-t5.1", "type": "adjacent_to", "arg1_id": "DerHautarzt.00510332.eng.abstr-s3-t2", "arg2_id": "DerHautarzt.00510332.eng.abstr-s2-t5", "normalized": [] }, { "id": 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DerHautarzt.00510336.eng.abstr	DerHautarzt.00510336.eng.abstr	[ { "id": "DerHautarzt.00510336.eng.abstr-passage-0", "type": "abstract", "text": [ "The Stewart-Bluefarb syndrome is defined as an unilateral angiodermatitis due to multiple arterio-venous fistules accompanied by acroangiodermatitis resembling Kaposi sarcoma ( pseudo-kaposi sarcoma ) . The acroangiodermatitis is most common on the lower limb . It leads to ulcerated nodules with a high risk of bleeding and infection , as well as edema , pain and seldom limb hypertrophy . Curative therapy requires elimination of the arteriovenous shunts . Surgical destruction of the multiple small fistulae is a limitating factor . A better alternative is embolisation , but this approach carries the risk of ischemia and necrosis . A 32 year old female patient with Stewart-Bluefarb syndrome is presented ; she has been successfully treated with embolisation on eight occasions ." ], "offsets": [ [ 0, 784 ] ] } ]	[ { "id": "DerHautarzt.00510336.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "syndrome" ], "offsets": [ [ 21, 29 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "DerHautarzt.00510336.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "sarcoma" ], "offsets": [ [ 167, 174 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036210" } ] }, { "id": "DerHautarzt.00510336.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "sarcoma" ], "offsets": [ [ 191, 198 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036210" } ] }, { "id": "DerHautarzt.00510336.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "Kaposi sarcoma" ], "offsets": [ [ 160, 174 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036220" } ] }, { "id": "DerHautarzt.00510336.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "limb" ], "offsets": [ [ 255, 259 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015385" } ] }, { "id": "DerHautarzt.00510336.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "lower limb" ], "offsets": [ [ 249, 259 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023216" } ] }, { "id": "DerHautarzt.00510336.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "risk" ], "offsets": [ [ 304, 308 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "DerHautarzt.00510336.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "infection" ], "offsets": [ [ 325, 334 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021311" } ] }, { "id": "DerHautarzt.00510336.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "edema" ], "offsets": [ [ 348, 353 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013604" } ] }, { "id": "DerHautarzt.00510336.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 356, 360 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerHautarzt.00510336.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "limb" ], "offsets": [ [ 372, 376 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015385" } ] }, { "id": "DerHautarzt.00510336.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "hypertrophy" ], "offsets": [ [ 377, 388 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020564" } ] }, { "id": "DerHautarzt.00510336.eng.abstr-s3-t7", "type": "umlsterm", "text": [ "risk of" ], "offsets": [ [ 304, 311 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "DerHautarzt.00510336.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 400, 407 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerHautarzt.00510336.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "Surgical" ], "offsets": [ [ 459, 467 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "DerHautarzt.00510336.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "fistulae" ], "offsets": [ [ 502, 510 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016169" } ] }, { "id": "DerHautarzt.00510336.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "embolisation" ], "offsets": [ [ 560, 572 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013931" } ] }, { "id": "DerHautarzt.00510336.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "risk" ], "offsets": [ [ 605, 609 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "DerHautarzt.00510336.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "ischemia" ], "offsets": [ [ 613, 621 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022116" } ] }, { "id": "DerHautarzt.00510336.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "necrosis" ], "offsets": [ [ 626, 634 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027540" } ] }, { "id": "DerHautarzt.00510336.eng.abstr-s6-t5", "type": "umlsterm", "text": [ "risk of" ], "offsets": [ [ 605, 612 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "DerHautarzt.00510336.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "old" ], "offsets": [ [ 647, 650 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0331059" } ] }, { "id": "DerHautarzt.00510336.eng.abstr-s7-t2", "type": "umlsterm", "text": [ "female" ], "offsets": [ [ 651, 657 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086287" }, { "db_name": "UMLS", "db_id": "C0015780" } ] }, { "id": "DerHautarzt.00510336.eng.abstr-s7-t3", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 658, 665 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510336.eng.abstr-s7-t4", "type": "umlsterm", "text": [ "syndrome" ], "offsets": [ [ 688, 696 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "DerHautarzt.00510336.eng.abstr-s7-t5", "type": "umlsterm", "text": [ "embolisation" ], "offsets": [ [ 751, 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DerHautarzt.00510345.eng.abstr	DerHautarzt.00510345.eng.abstr	[ { "id": "DerHautarzt.00510345.eng.abstr-passage-0", "type": "abstract", "text": [ "A 60-years old female patient developed juxta-articular fibroid nodules and erythrocyanotic lesions of acrodermatitis chronica atrophicans after several tick bites . The woman was treated with ceftriaxon ( Rocephin ) 2 g daily parenterally without adverse reactions ." ], "offsets": [ [ 0, 267 ] ] } ]	[ { "id": "DerHautarzt.00510345.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "old" ], "offsets": [ [ 11, 14 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0331059" } ] }, { "id": "DerHautarzt.00510345.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "female" ], "offsets": [ [ 15, 21 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086287" }, { "db_name": "UMLS", "db_id": "C0015780" } ] }, { "id": "DerHautarzt.00510345.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 22, 29 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510345.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "fibroid" ], "offsets": [ [ 56, 63 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023267" }, { "db_name": "UMLS", "db_id": "C0042133" } ] }, { "id": "DerHautarzt.00510345.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "acrodermatitis" ], "offsets": [ [ 103, 117 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001197" } ] }, { "id": "DerHautarzt.00510345.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "tick" ], "offsets": [ [ 153, 157 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040203" }, { "db_name": "UMLS", "db_id": "C0040196" } ] }, { "id": "DerHautarzt.00510345.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "bites" ], "offsets": [ [ 158, 163 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005658" } ] }, { "id": "DerHautarzt.00510345.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "woman" ], "offsets": [ [ 170, 175 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043210" } ] }, { "id": "DerHautarzt.00510345.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "ceftriaxon" ], "offsets": [ [ 193, 203 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007561" } ] }, { "id": "DerHautarzt.00510345.eng.abstr-s2-t3", "type": "umlsterm", "text": [ 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DerHautarzt.00510349.eng.abstr	DerHautarzt.00510349.eng.abstr	[ { "id": "DerHautarzt.00510349.eng.abstr-passage-0", "type": "abstract", "text": [ "Atypical mycobacterial infections of the skin present a diagnostic and therapeutic challenge to dermatologists in many instances . We report on a patient who was diagnosed with atypical mycobacteriosis in its rarer , sporotrichoid form . Possible differential diagnoses are discussed . Efficient therapy using minocycline is demonstrated ." ], "offsets": [ [ 0, 339 ] ] } ]	[ { "id": "DerHautarzt.00510349.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "infections" ], "offsets": [ [ 23, 33 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021311" } ] }, { "id": "DerHautarzt.00510349.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "skin" ], "offsets": [ [ 41, 45 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] }, { "id": "DerHautarzt.00510349.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "diagnostic" ], "offsets": [ [ 56, 66 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerHautarzt.00510349.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "therapeutic" ], "offsets": [ [ 71, 82 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "DerHautarzt.00510349.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "mycobacterial infections" ], "offsets": [ [ 9, 33 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026918" } ] }, { "id": "DerHautarzt.00510349.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "Atypical mycobacterial infections" ], "offsets": [ [ 0, 33 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026919" } ] }, { "id": "DerHautarzt.00510349.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 146, 153 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510349.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "mycobacteriosis" ], "offsets": [ [ 186, 201 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026918" } ] }, { "id": "DerHautarzt.00510349.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "form" ], "offsets": [ [ 231, 235 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376315" } ] }, { "id": "DerHautarzt.00510349.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "differential diagnoses" ], "offsets": [ [ 247, 269 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011906" } ] }, { "id": "DerHautarzt.00510349.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 296, 303 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerHautarzt.00510349.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "minocycline" ], "offsets": [ [ 310, 321 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026187" } ] } ]	[]	[]	[ { "id": "DerHautarzt.00510349.eng.abstr-s1-r1-t2.1-t6.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510349.eng.abstr-s4-t2", "arg2_id": "DerHautarzt.00510349.eng.abstr-s1-t6", "normalized": [] }, { "id": "DerHautarzt.00510349.eng.abstr-s1-r2-t2.1-t5.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510349.eng.abstr-s4-t2", "arg2_id": "DerHautarzt.00510349.eng.abstr-s1-t5", "normalized": [] }, { "id": "DerHautarzt.00510349.eng.abstr-s1-r3-t2.1-t1.1", "type": "location_of", "arg1_id": "DerHautarzt.00510349.eng.abstr-s4-t2", "arg2_id": 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"DerHautarzt.00510349.eng.abstr-s2-r1-t1.1-t3.1", "type": "uses", "arg1_id": "DerHautarzt.00510349.eng.abstr-s4-t1", "arg2_id": "DerHautarzt.00510349.eng.abstr-s2-t3", "normalized": [] }, { "id": "DerHautarzt.00510349.eng.abstr-s2-r2-t2.1-t1.1", "type": "occurs_in", "arg1_id": "DerHautarzt.00510349.eng.abstr-s4-t2", "arg2_id": "DerHautarzt.00510349.eng.abstr-s4-t1", "normalized": [] }, { "id": "DerHautarzt.00510349.eng.abstr-s2-r3-t3.1-t2.1", "type": "causes", "arg1_id": "DerHautarzt.00510349.eng.abstr-s2-t3", "arg2_id": "DerHautarzt.00510349.eng.abstr-s4-t2", "normalized": [] } ]
DerHautarzt.00510387.eng.abstr	DerHautarzt.00510387.eng.abstr	[ { "id": "DerHautarzt.00510387.eng.abstr-passage-0", "type": "abstract", "text": [ "Dermatitis herpetiformis is associated with celiac disease . IgA antibodies to endomysium are considered as sensitive and specific markers for celiac disease . Recently , tissue transglutaminase was identified as the antigen of anti-endomysium antibodies . Moreover , serum levels of IgA antibodies to tissue transglutaminase were found to correlate with titers of IgA antibodies to endomysium in patients with both celiac disease and dermatitis herpetiformis . These findings confirm the close pathogenic relation between the two diseases . The determination of serum levels of antibodies to tissue transglutaminase may be a tool that can be routinely used for the diagnosis of dermatitis herpetiformis in the future ." ], "offsets": [ [ 0, 719 ] ] } ]	[ { "id": "DerHautarzt.00510387.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Dermatitis" ], "offsets": [ [ 0, 10 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011603" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 51, 58 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "celiac disease" ], "offsets": [ [ 44, 58 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007570" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "IgA" ], "offsets": [ [ 61, 64 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020835" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "antibodies" ], "offsets": [ [ 65, 75 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003241" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "markers" ], "offsets": [ [ 131, 138 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005516" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 150, 157 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "celiac disease" ], "offsets": [ [ 143, 157 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007570" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "tissue" ], "offsets": [ [ 171, 177 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040300" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "transglutaminase" ], "offsets": [ [ 178, 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"id": "DerHautarzt.00510387.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "transglutaminase" ], "offsets": [ [ 309, 325 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033679" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "IgA" ], "offsets": [ [ 365, 368 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020835" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s4-t6", "type": "umlsterm", "text": [ "antibodies" ], "offsets": [ [ 369, 379 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003241" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s4-t7", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 397, 405 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s4-t8", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 423, 430 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s4-t9", "type": "umlsterm", "text": [ "dermatitis" ], "offsets": [ [ 435, 445 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011603" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s4-t10", "type": "umlsterm", "text": [ "celiac disease" ], "offsets": [ [ 416, 430 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007570" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "findings" ], "offsets": [ [ 468, 476 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243095" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "diseases" ], "offsets": [ [ 531, 539 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "determination" ], "offsets": [ [ 546, 559 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002778" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "antibodies" ], "offsets": [ [ 579, 589 ] ], 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"type": "interacts_with", "arg1_id": "DerHautarzt.00510387.eng.abstr-s6-t4", "arg2_id": "DerHautarzt.00510387.eng.abstr-s6-t1", "normalized": [] }, { "id": "DerHautarzt.00510387.eng.abstr-s6-r23-t3.1-t1.1", "type": "produces", "arg1_id": "DerHautarzt.00510387.eng.abstr-s6-t3", "arg2_id": "DerHautarzt.00510387.eng.abstr-s6-t1", "normalized": [] }, { "id": "DerHautarzt.00510387.eng.abstr-s6-r24-t5.1-t4.1", "type": "analyzes", "arg1_id": "DerHautarzt.00510387.eng.abstr-s6-t5", "arg2_id": "DerHautarzt.00510387.eng.abstr-s6-t4", "normalized": [] } ]

DerGynaekologe.90320046.eng.abstr

[ { "id": "DerGynaekologe.90320046.eng.abstr-passage-0", "type": "abstract", "text": [ "Hypertensive disorders complicating pregnancy are a major cause of maternal and perinatal morbidity and mortality . Intensive ambulatory obstetric care is likley to achieve a risk reduction with the following topics : early identification of typical signs of preeclampsia , detection of uteroplacental insufficiency and their consequences and early admission to a specialized obstetric care unit or perinatal center . There are no established methods for the prevention of preeclampsia . Women who are at increased risk for having preeclampsia in subsequent pregnancies might be appropriate candidates for low-dose aspirin during pregnancy ; prophylactic calcium supplementation is controversial . To prevent cerebrovascular complications antihypertensive therapy is mandatory . Alpha-Methyl-dopa is the initial drug of choice for oral long-term treatment . In severe preeclampsia continuous monitoring and laboratory evalution of the mother and the fetus are required . Immediate introduction of therapy , including continuous infusion of magnesium sulfate to prevent convulsions , hydralzine to reduce blood pressure and careful volume expansion , is necessary . Under intensive monitoring , prolongation of pregnancy in patients at 25 to 32 weeks ' gestation is reasonable under the following conditions : stable maternal condition , no suspected or manifest DIC and fetal well-being . Immediate delivery is indicated in cases of therapy-refractary severe preeclampsia , imminent eclampsia , after an eclamptic convulsion , and signs of intrauterine fetal asphyxia ." ], "offsets": [ [ 0, 1569 ] ] } ]

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"db_id": "C0026565" } ] }, { "id": "DerGynaekologe.90320046.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "Hypertensive disorders" ], "offsets": [ [ 0, 22 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020538" } ] }, { "id": "DerGynaekologe.90320046.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "care" ], "offsets": [ [ 147, 151 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0150499" } ] }, { "id": "DerGynaekologe.90320046.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "risk" ], "offsets": [ [ 175, 179 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "DerGynaekologe.90320046.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "identification" ], "offsets": [ [ 224, 238 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020792" } ] }, { "id": "DerGynaekologe.90320046.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "signs" ], "offsets": [ [ 250, 255 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220912" } ] }, { "id": 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[]

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DerGynaekologe.90320055.eng.abstr

[ { "id": "DerGynaekologe.90320055.eng.abstr-passage-0", "type": "abstract", "text": [ "Delivering women gently and safely by avoiding perinatal asphyxia , preterm delivery and ascending intrauterine infection may help to protect babies from cerebral damage during and after birth . The self-determination of women should not be restricted by unnecessary diagnostic and therapeutic interventions . In contrast , obstetricians should cooperate with women to assure an appropriate balance between personal freedom of the mother and safety for the baby during delivery ." ], "offsets": [ [ 0, 479 ] ] } ]

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[]

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DerGynaekologe.90320060.eng.abstr

[ { "id": "DerGynaekologe.90320060.eng.abstr-passage-0", "type": "abstract", "text": [ "The routine application of ultrasound in pregnancy has had an important impact on perinatal medicine . New trends in perinatal medicine , aiming at more individual and self-determined pregnancy and delivery , are realizable because of the safety provided by ultrasound . Often prenatal ultrasound is regarded as only being able to detect fetal malformations , but ultrasound provides many more benefits for a safe pregnancy : early detection of fetal viability ; intrauterine localization of the pregnancy ; exact determination of the gestational age in early pregnancy ; later in pregnancy , confirmation of appropriate fetal growth , position and localization of placenta site . In addition , the development of close mother-child bonding by visualizing the fetus could be of positive impact . These aspects are contributions of ultrasound to a gentle and safe pregnancy and delivery for mother and child ." ], "offsets": [ [ 0, 908 ] ] } ]

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DerGynaekologe.90320083.eng.abstr

[ { "id": "DerGynaekologe.90320083.eng.abstr-passage-0", "type": "abstract", "text": [ "Extremely radical and radical surgical treatment of breast cancer was investigated with regard to indication , prognosis and local recurrence in comparison to current standard breast-conserving procedures . Plastic-reconstructive techniques and innovative therapeutical approaches such as preoperative chemotherapy can extend the indications for breast-conserving therapy without loss of oncological safety . Choosing individually various oncoplastic techniques such as glandular adaptation , local or distant flaps or mammoplasty permits breast remodeling with excellent cosmetic results . We present the variety of intraglandular techniques and local flaps that enable the breast surgeon to achieve good symmetry and breast shape with minimal surgery and scarring ." ], "offsets": [ [ 0, 767 ] ] } ]

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"db_id": "C0033325" } ] }, { "id": "DerGynaekologe.90320083.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "recurrence" ], "offsets": [ [ 131, 141 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034897" } ] }, { "id": "DerGynaekologe.90320083.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "standard" ], "offsets": [ [ 167, 175 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038137" }, { "db_name": "UMLS", "db_id": "C0175675" } ] }, { "id": "DerGynaekologe.90320083.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "procedures" ], "offsets": [ [ 194, 204 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0184661" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerGynaekologe.90320083.eng.abstr-s1-t9", "type": "umlsterm", "text": [ "surgical treatment" ], "offsets": [ [ 30, 48 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0543467" } ] }, { "id": "DerGynaekologe.90320083.eng.abstr-s1-t10", "type": "umlsterm", "text": [ "breast cancer" ], "offsets": [ [ 52, 65 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006142" } ] }, { "id": "DerGynaekologe.90320083.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "Plastic-reconstructive" ], "offsets": [ [ 207, 229 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032167" } ] }, { "id": "DerGynaekologe.90320083.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "techniques" ], "offsets": [ [ 230, 240 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerGynaekologe.90320083.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "chemotherapy" ], "offsets": [ [ 302, 314 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013216" }, { "db_name": "UMLS", "db_id": "C0013217" } ] }, { "id": "DerGynaekologe.90320083.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 364, 371 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerGynaekologe.90320083.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "safety" ], "offsets": [ [ 400, 406 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036043" } ] }, { "id": "DerGynaekologe.90320083.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "techniques" ], "offsets": [ [ 451, 461 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerGynaekologe.90320083.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "adaptation" ], "offsets": [ [ 480, 490 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000934" } ] }, { "id": "DerGynaekologe.90320083.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "flaps" ], "offsets": [ [ 510, 515 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038925" } ] }, { "id": "DerGynaekologe.90320083.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "mammoplasty" ], "offsets": [ [ 519, 530 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0085076" } ] }, { "id": "DerGynaekologe.90320083.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "breast" ], "offsets": [ [ 539, 545 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006141" }, { "db_name": "UMLS", "db_id": "C0006142" } ] }, { "id": "DerGynaekologe.90320083.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "cosmetic" ], "offsets": [ [ 572, 580 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010164" } ] }, { "id": "DerGynaekologe.90320083.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "techniques" ], "offsets": [ [ 632, 642 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerGynaekologe.90320083.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "flaps" ], "offsets": [ [ 653, 658 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038925" } ] }, { "id": "DerGynaekologe.90320083.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "breast" ], "offsets": [ [ 675, 681 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006141" }, { "db_name": "UMLS", "db_id": "C0006142" } ] }, { "id": "DerGynaekologe.90320083.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "breast" ], "offsets": [ [ 719, 725 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006141" }, { "db_name": "UMLS", "db_id": "C0006142" } ] }, { "id": "DerGynaekologe.90320083.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "surgery" ], "offsets": [ [ 745, 752 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038894" }, { "db_name": "UMLS", "db_id": "C0038895" } ] } ]

[]

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DerGynaekologe.90320091.eng.abstr

[ { "id": "DerGynaekologe.90320091.eng.abstr-passage-0", "type": "abstract", "text": [ "Carcinoma of the breast is the most frequent malignancy in woman . Moreover , the incidence of the disease is rising in the younger age groups . Recent advances in the primary surgical treatment of breast cancer have demonstrated that it is possible to bring about a long-term improvement in the patient's quality of life without compromising the prognosis . Depending on the breast volume and the size of the primary tumor , the surgeon can now offer the breast cancer patient a number of options . These include the entire range of breast-conserving techniques ( both volume reduction and volumetric replacement ) and the use of implants or autogenous tissue for breast reconstruction following - or simultaneous with - mastectomy . In cases where breast-conserving surgery is feasible , partial or modified radical mastectomy can be followed by autogenous tissue reconstruction with TRAM or latissimus dorsi flaps . Because of their safety and versatility , latissimus dorsi musculocutaneous flaps are currently making a remarkable comeback ." ], "offsets": [ [ 0, 1045 ] ] } ]

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"C0021149" } ] }, { "id": "DerGynaekologe.90320091.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 99, 106 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerGynaekologe.90320091.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "age" ], "offsets": [ [ 132, 135 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001792" }, { "db_name": "UMLS", "db_id": "C0001811" } ] }, { "id": "DerGynaekologe.90320091.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "age groups" ], "offsets": [ [ 132, 142 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027362" } ] }, { "id": "DerGynaekologe.90320091.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "surgical" ], "offsets": [ [ 176, 184 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "DerGynaekologe.90320091.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 185, 194 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerGynaekologe.90320091.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "breast" ], "offsets": [ [ 198, 204 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006141" }, { "db_name": "UMLS", "db_id": "C0006142" } ] }, { "id": "DerGynaekologe.90320091.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "cancer" ], "offsets": [ [ 205, 211 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006826" } ] }, { "id": "DerGynaekologe.90320091.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "life" ], "offsets": [ [ 317, 321 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376558" } ] }, { "id": "DerGynaekologe.90320091.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "prognosis" ], "offsets": [ [ 347, 356 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033325" } ] }, { "id": "DerGynaekologe.90320091.eng.abstr-s3-t7", "type": "umlsterm", "text": [ "surgical treatment" ], "offsets": [ [ 176, 194 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0543467" } ] }, { "id": "DerGynaekologe.90320091.eng.abstr-s3-t8", "type": "umlsterm", "text": [ "breast cancer" ], "offsets": [ [ 198, 211 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006142" } ] }, { "id": "DerGynaekologe.90320091.eng.abstr-s3-t9", "type": "umlsterm", "text": [ "quality of life" ], "offsets": [ [ 306, 321 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034380" } ] }, { "id": "DerGynaekologe.90320091.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "breast" ], "offsets": [ [ 376, 382 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006141" }, { "db_name": "UMLS", "db_id": "C0006142" } ] }, { "id": "DerGynaekologe.90320091.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "tumor" ], "offsets": [ [ 418, 423 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerGynaekologe.90320091.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "breast" ], "offsets": [ [ 456, 462 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006141" }, { "db_name": "UMLS", "db_id": "C0006142" } ] }, { "id": "DerGynaekologe.90320091.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "cancer" ], "offsets": [ [ 463, 469 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006826" } ] }, { "id": "DerGynaekologe.90320091.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 470, 477 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerGynaekologe.90320091.eng.abstr-s4-t6", "type": "umlsterm", "text": [ "breast cancer" ], "offsets": [ [ 456, 469 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006142" } ] }, { "id": "DerGynaekologe.90320091.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "techniques" ], "offsets": [ [ 552, 562 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerGynaekologe.90320091.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "use" ], "offsets": [ [ 624, 627 ] ], "normalized": [ { "db_name": "UMLS", "db_id": 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"normalized": [ { "db_name": "UMLS", "db_id": "C0085076" } ] }, { "id": "DerGynaekologe.90320091.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "surgery" ], "offsets": [ [ 768, 775 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038894" }, { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "DerGynaekologe.90320091.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "mastectomy" ], "offsets": [ [ 818, 828 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024881" }, { "db_name": "UMLS", "db_id": "C0024886" } ] }, { "id": "DerGynaekologe.90320091.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "tissue" ], "offsets": [ [ 859, 865 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040300" } ] }, { "id": "DerGynaekologe.90320091.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "flaps" ], "offsets": [ [ 911, 916 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038925" } ] }, { "id": "DerGynaekologe.90320091.eng.abstr-s6-t5", "type": "umlsterm", "text": [ "breast-conserving 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[]

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"arg1_id": "DerGynaekologe.90320091.eng.abstr-s6-t3", "arg2_id": "DerGynaekologe.90320091.eng.abstr-s6-t5", "normalized": [] }, { "id": "DerGynaekologe.90320091.eng.abstr-s6-r9-t3.1-t4.1", "type": "developmental_form_of", "arg1_id": "DerGynaekologe.90320091.eng.abstr-s6-t3", "arg2_id": "DerGynaekologe.90320091.eng.abstr-s6-t4", "normalized": [] }, { "id": "DerGynaekologe.90320091.eng.abstr-s6-r10-t4.1-t5.1", "type": "location_of", "arg1_id": "DerGynaekologe.90320091.eng.abstr-s6-t4", "arg2_id": "DerGynaekologe.90320091.eng.abstr-s6-t5", "normalized": [] }, { "id": "DerGynaekologe.90320091.eng.abstr-s6-r11-t4.1-t3.1", "type": "surrounds", "arg1_id": "DerGynaekologe.90320091.eng.abstr-s6-t4", "arg2_id": "DerGynaekologe.90320091.eng.abstr-s6-t3", "normalized": [] }, { "id": "DerGynaekologe.90320091.eng.abstr-s6-r12-t1.2-t1.1", "type": "issue_in", "arg1_id": "DerGynaekologe.90320091.eng.abstr-s6-t1", "arg2_id": "DerGynaekologe.90320091.eng.abstr-s7-t1", "normalized": [] }, { "id": "DerGynaekologe.90320091.eng.abstr-s6-r13-t3.1-t2.2", "type": "location_of", "arg1_id": "DerGynaekologe.90320091.eng.abstr-s6-t3", "arg2_id": "DerGynaekologe.90320091.eng.abstr-s6-t2", "normalized": [] } ]

DerGynaekologe.90320098.eng.abstr

[ { "id": "DerGynaekologe.90320098.eng.abstr-passage-0", "type": "abstract", "text": [ "Immediate breast reconstruction can now be offered to almost all patients who need a mastectomy . The single-pedicle TRAM-flap from the contralateral rectus abdominis muscle offers adequate volume and skin to replace that removed , and also good modelling capacity for symmetrical reconstruction of the breast shape . Experience of over 500 cases between 1984 and 1997 shows that the single-pedicle flap is as safe as the two-pedicle flap . The complication rate and the frequency with which revision operations were needed amounted to a total of 12.6 % . Immediate reconstruction following carcinoma extends the individual spectrum of treatment options with reference to primary treatment tailored to the tumour and is characterized by the decisive quality criterion of subsequent freedom from local recurrence ." ], "offsets": [ [ 0, 813 ] ] } ]

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[]

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DerGynaekologe.90320106.eng.abstr

[ { "id": "DerGynaekologe.90320106.eng.abstr-passage-0", "type": "abstract", "text": [ "In recent years the indication for a mastectomy for breast cancer has been increasingly restricted . The use of plastic reconstructive techniques enhances the rate of breast-conserving therapy even for large breast tumors with excellent cosmetic results and oncological safety . The breast-to-tumor ratio and locally complete resection with free tumor margins of 1-2 cm are the most important factors in breast-conserving surgery . Different techniques of reduction mammoplasty within the concept of oncological breast surgery not only allow large tumors in large breasts to be resected , but also relatively large tumors in normal sized or even smaller breasts to be resected . Other advantages are the reduction of breast size and therefore target volume before postoperative radiation procedures as well as in cancer prophylaxis and risk reduction by reducing ipsi- and contralateral breast tissue . Reduction mammoplasty techniques with different resection areas have to be selected for individual tumor locations . The best symmetry is achieved by bilateral mammoplasty in a one step procedure with lumpectomy and axillary dissection . Oncoplastic or reconstructive surgery in the target breast is often followed by procedures to improve symmetry by contralateral reduction . Whenever possible , mammoplasty techniques with minimal scarring should be chosen out of a variety of reduction procedures ." ], "offsets": [ [ 0, 1405 ] ] } ]

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DerGynaekologe.90320121.eng.abstr

[ { "id": "DerGynaekologe.90320121.eng.abstr-passage-0", "type": "abstract", "text": [ "Reconstruction of the vulva and vagina is mandatory in gynecological surgery . Any gynecologist should be familiar with the different surgical options and should know which center is most appropriate to refer the patient . Careful operative techniques and intensive perioperative management are decisive for good healing results . An optimal anatomic and functional outcome is part of global psychosomatic treatment ." ], "offsets": [ [ 0, 417 ] ] } ]

[ { "id": "DerGynaekologe.90320121.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "vulva" ], "offsets": [ [ 22, 27 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042993" }, { "db_name": "UMLS", "db_id": "C0375071" } ] }, { "id": "DerGynaekologe.90320121.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "vagina" ], "offsets": [ [ 32, 38 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042251" }, { "db_name": "UMLS", "db_id": "C0042232" } ] }, { "id": "DerGynaekologe.90320121.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "surgery" ], "offsets": [ [ 69, 76 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038894" }, { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "DerGynaekologe.90320121.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "gynecological surgery" ], "offsets": [ [ 55, 76 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038902" } ] }, { "id": "DerGynaekologe.90320121.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "surgical" ], "offsets": [ [ 134, 142 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "DerGynaekologe.90320121.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 213, 220 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerGynaekologe.90320121.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "techniques" ], "offsets": [ [ 241, 251 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerGynaekologe.90320121.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "anatomic" ], "offsets": [ [ 342, 350 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220784" } ] }, { "id": "DerGynaekologe.90320121.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 406, 415 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] } ]

[]

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DerGynaekologe.90320169.eng.abstr

[ { "id": "DerGynaekologe.90320169.eng.abstr-passage-0", "type": "abstract", "text": [ "With the high-resolution ultrasound technology available today , the rapid embryofetal development during the first trimester can be imaged in detail . Thus , malformations can also be recognized if especially searched for . In the literature an enormous number of ultrasonographic normal values concerning early pregnancy have been published , and there are innumerable case reports of early diagnosed malformations of various organ systems . With a targeted search more than half of anomalies detectable in the second trimester can be seen at the end of the first trimester . These data , however , are insufficient to justify the introduction of early screening for fetal anomalies . With a burdened history a targeted exclusion diagnosis can contribute to the first psychological relief of the parents . If there are abnormal findings , in many cases the prognosis can not be ascertained and some anomalies appear only temporarily in later healthy children . Therefore , hasty conclusions should be avoided ." ], "offsets": [ [ 0, 1012 ] ] } ]

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[]

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DerGynaekologe.90320181.eng.abstr

[ { "id": "DerGynaekologe.90320181.eng.abstr-passage-0", "type": "abstract", "text": [ "The uniform development of the human embryo , as described by classic human embryology , has been confirmed by sonoembryological studies . In particular , the embryonic brain is suitable for transvaginal ultrasound examination , because the large \" cystic \" cavities of the brain can easily be imaged . Sonoembryology not only describes normal embryonic anatomy and normal relations and proportions of organs , but also the development of structural abnormalities . Approximately one-third of all congenital anomalies , originate from the central nervous system ( CNS ) . Based on normal sonoembryology and on recent experiences with early CNS anomalies , we recognize some sonographic signs of an early CNS anomaly : ( 1 ) Apparent dysmorphology of the brain or the head ; ( 2 ) Altered appearance of the cerebral ventricles with disproportion of the brain compartments , where the amount of fluid is either greater or less than normal ; ( 3 ) In the early fetal period , choroid plexuses that are too small to fill the ventricle from the medial to the lateral wall ; ( 4 ) Irregular contour of the spine/back ; ( 5 ) Extra-CNS anomalies . In the following survey , normal sonoembryology of the CNS is described , and CNS anomalies of the early pregnancy are discussed ." ], "offsets": [ [ 0, 1271 ] ] } ]

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[]

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DerGynaekologe.90320193.eng.abstr

[ { "id": "DerGynaekologe.90320193.eng.abstr-passage-0", "type": "abstract", "text": [ "In about 80 % of fetuses with trisomies 21 , 18 or 13 and Turner syndrome there is an increased collection of fluid in the neck region that can be visualized sonographically at 10-14 weeks gestation as increased nuchal translucency thickness . The pathophysiology of this common phenotypic expression of different chromosomal abnormalities is uncertain , but there is some evidence that the underlying mechanism may be cardiac failure , possibly due to abnormalities of the heart and great arteries , and altered composition of the extracellular matrix of tissues , which can be also noticed in the skin . The latter may be due to a gene dosage effect of the three rather than the normal two copies of genes found in trisomies , causing an alteration of the extracellular matrix in the skin or abnormal development of the heart and great arteries ." ], "offsets": [ [ 0, 848 ] ] } ]

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[]

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"arg2_id": "DerGynaekologe.90320193.eng.abstr-s3-t5", "normalized": [] }, { "id": "DerGynaekologe.90320193.eng.abstr-s3-r41-t7.1-t4.1", "type": "conceptual_part_of", "arg1_id": "DerGynaekologe.90320193.eng.abstr-s3-t7", "arg2_id": "DerGynaekologe.90320193.eng.abstr-s3-t4", "normalized": [] }, { "id": "DerGynaekologe.90320193.eng.abstr-s3-r42-t3.1-t6.1", "type": "part_of", "arg1_id": "DerGynaekologe.90320193.eng.abstr-s3-t3", "arg2_id": "DerGynaekologe.90320193.eng.abstr-s3-t6", "normalized": [] }, { "id": "DerGynaekologe.90320193.eng.abstr-s3-r43-t6.1-t11.1", "type": "location_of", "arg1_id": "DerGynaekologe.90320193.eng.abstr-s3-t6", "arg2_id": "DerGynaekologe.90320193.eng.abstr-s3-t11", "normalized": [] } ]

DerGynaekologe.90320200.eng.abstr

[ { "id": "DerGynaekologe.90320200.eng.abstr-passage-0", "type": "abstract", "text": [ "There has been an increase in the use of fetal ultrasound in the first trimester over the last few years . This paper reviews the published literature on first trimester fetal nuchal translucency . Increased nuchal translucency ( NT ) may identify more than 80 % of chromosomal anomalies for a false-positive rate of about 5 % . Another potential of early NT measurement lies in the detection of other fetal anomalies like structural defects , genetic disorders , or early fetal hydrops and may present an early sign of twin-twin transfusion syndrome in monochorionic pregnancies . The association of fetal NT and main fetal disorders is reviewed . The clinical prenatal management options for parents regarding the early detection of high-risk groups and the detection of fetal anomalies are discussed ." ], "offsets": [ [ 0, 804 ] ] } ]

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"id": "DerGynaekologe.90320200.eng.abstr-s4-t13", "type": "umlsterm", "text": [ "twin-twin transfusion syndrome" ], "offsets": [ [ 520, 550 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015958" } ] }, { "id": "DerGynaekologe.90320200.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "association" ], "offsets": [ [ 586, 597 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004083" } ] }, { "id": "DerGynaekologe.90320200.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "disorders" ], "offsets": [ [ 625, 634 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerGynaekologe.90320200.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "fetal disorders" ], "offsets": [ [ 619, 634 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015929" } ] }, { "id": "DerGynaekologe.90320200.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "parents" ], "offsets": [ [ 694, 701 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030551" } ] }, { "id": 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[]

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DerGynaekologe.90320213.eng.abstr

[ { "id": "DerGynaekologe.90320213.eng.abstr-passage-0", "type": "abstract", "text": [ "Three-dimensional imaging with the capacity for automatic data acquisition and volume storage provides the possibility of analyzing structures tomographically in certain steps . Sectional planes that cannot be demonstrated by conventional ultrasound can be calculated and displayed from the volume memory . In addition , three-dimensional images may be calculated using the surface and transparent mode . With those different viewing modes and permanent storage of the acquired volumes , the transvaginal 3-D technique offers a precise diagnosis in early pregnancy ." ], "offsets": [ [ 0, 566 ] ] } ]

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[]

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DerGynaekologe.90320220.eng.abstr

[ { "id": "DerGynaekologe.90320220.eng.abstr-passage-0", "type": "abstract", "text": [ "Transvaginal ultrasound provides an early and accurate technique to assess first trimester pregnancy . Beginning with the demonstration of an intrauterine gestational sac , sonography enables further evaluation of normal pregnancy development , such as identification of the embryo , visualization of the yolk sac , and the presence of fetal cardiac activity as a reassurance of fetal viability . Furthermore it allows closed sonographic monitoring of early intrauterine pregnancy and distinction between normal and abnormal development of pregnancy . A prediction in terms of pregnancy outcome can be made regarding pregnancy complications or specific risks like vaginal bleeding , the demonstration of intrauterine hematoma , advanced maternal age , early growth delay or fetal bradycardia ." ], "offsets": [ [ 0, 793 ] ] } ]

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"arg2_id": "DerGynaekologe.90320220.eng.abstr-s4-t1", "normalized": [] } ]

DerGynaekologe.90320247.eng.abstr

[ { "id": "DerGynaekologe.90320247.eng.abstr-passage-0", "type": "abstract", "text": [ "Molecular and epidemiological studies have confirmed that human pathogenic papillomaviruses ( HPV ) types 16 and 18 are causally involved in the developement of carcinoma of the cervix . This statement is also true , albeit with reservations as yet , of other so-called high-risk HPV types , such as HPV 31 , 33 , 35 , 39 , 45 , 51 , 52 , 56 and 58. Around 500,000 women throughout the world become ill with carcinoma of the cervix every year , and 1-4% of all younger women have a precancer of the cervix uteri . This knowledge of the viral origin of anogenital neoplasms has not yet been exploited for primary and secondary prevention of these illnesses , however . This is mainly because infection with genital HPV types is very prevalent in young women but seldom leads to carcinoma . In this review , therefore , the most important epidemiological data available on cervical carcinoma and its preliminary stages are analysed with reference to an association with HPV . In addition , the molecular biological data on HPV as it relates to anogenital carcinogenesis are presented . In conclusion , the significance of HPV for the prevention of carcinoma of the cervix is discussed ." ], "offsets": [ [ 0, 1184 ] ] } ]

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[]

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DerGynaekologe.90320273.eng.abstr

[ { "id": "DerGynaekologe.90320273.eng.abstr-passage-0", "type": "abstract", "text": [ "Laparoscopic procedures have attained increasing importance in the diagnosis and therapy of carcinoma of the cervix in recent years ( Table 1 ) [ 34 ] . Laparoscopic pelvic and para-aortal lymphadenectomies are therefore performed to assess the operability of carcinoma of the cervix and for its staging . In the case of primarily operable tumours , paraortal and pelvic lymphadenectomy is carried out by a laparoscopic procedure , and when the lymph nodes are negative nodes and there is no intra-abdominal metastasis the lymphadenectomy is combined with laparoscopically assisted vaginal hysterectomy . If laparoscopy discloses positive lymph nodes , debulking can be carried out and the patient can be referred for radiotherapy . In addition , laparoscopic procedures , even in combination with radical cervicectomy for early invasive carcinoma of the cervix , can mean conservation of the patient's fertility . In the case of primarily inoperable tumours laparoscopy can be used to assess the lymph node status and the intra-abdominal tumour spread and to classify the patient's condition as potentially secondarily operable or inoperable . In addition , in the case of primarily undertreated patients whose carcinoma of the cervix has been diagnosed incidentally in preparations of tissue examined following hysterectomy , posttreatment in the form of laparoscopic lymphadenectomy and laparoscopically assisted colpectomy can be performed ." ], "offsets": [ [ 0, 1445 ] ] } ]

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], "normalized": [ { "db_name": "UMLS", "db_id": "C0007874" } ] }, { "id": "DerGynaekologe.90320273.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "Laparoscopic procedures" ], "offsets": [ [ 0, 23 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031150" } ] }, { "id": "DerGynaekologe.90320273.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "lymphadenectomies" ], "offsets": [ [ 189, 206 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024203" } ] }, { "id": "DerGynaekologe.90320273.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "carcinoma" ], "offsets": [ [ 260, 269 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007097" } ] }, { "id": "DerGynaekologe.90320273.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "cervix" ], "offsets": [ [ 277, 283 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007874" } ] }, { "id": "DerGynaekologe.90320273.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "tumours" ], "offsets": [ [ 340, 347 ] ], "normalized": [ { "db_name": "UMLS", 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[]

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DerGynaekologe.90320280.eng.abstr

[ { "id": "DerGynaekologe.90320280.eng.abstr-passage-0", "type": "abstract", "text": [ "The basic forms of therapy that can be applied in the treatment of advanced stages of carcinoma of the cervix are surgery and radiotherapy . While stage 1b ist treated by surgical operation , such as the extended radical operation after Wertheim and systematic lymphadenectomy after Meigs , in the vast majority of cases throughout the world , in the case of larger cervical tumours ( > 4 cm/1b2) and in stage IIb , with extension of the carcinoma into the parametrium , radiotherapy is mostly used . Data on tumour spread from the cervix by way of the parametrium into the pelvic lymph nodes show that prognostic factors allowing for an assessment of the individual patient's chances cannot be elaborated except on the basis of the histopathological investigation of the tissue resected during the radical operation . The 5-year survival rates show that the extended radical abdominal operation combined with radical pelvic lymphadenectomy , when performed in centres where there is special training and especially in the case of advanced tumours of the cervix ( FIGO stages lb2/IIb) and involved pelvic and/or para-aortal lymph nodes in the first ray , can yield results that are comparable to or even better than those of resection ." ], "offsets": [ [ 0, 1236 ] ] } ]

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[]

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"associated_with", "arg1_id": "DerGynaekologe.90320280.eng.abstr-s4-t4", "arg2_id": "DerGynaekologe.90320280.eng.abstr-s4-t2", "normalized": [] }, { "id": "DerGynaekologe.90320280.eng.abstr-s4-r35-t6.1-t2.1", "type": "location_of", "arg1_id": "DerGynaekologe.90320280.eng.abstr-s4-t6", "arg2_id": "DerGynaekologe.90320280.eng.abstr-s4-t2", "normalized": [] }, { "id": "DerGynaekologe.90320280.eng.abstr-s4-r36-t7.1-t4.1", "type": "associated_with", "arg1_id": "DerGynaekologe.90320280.eng.abstr-s4-t7", "arg2_id": "DerGynaekologe.90320280.eng.abstr-s4-t4", "normalized": [] } ]

DerGynaekologe.90320306.eng.abstr

[ { "id": "DerGynaekologe.90320306.eng.abstr-passage-0", "type": "abstract", "text": [ "Although carcinoma screening is now widely available , cervical carcinoma is still the fourth most common tumour among women in the USA and in the western industrialized nations . There are about 14,000 new cases every year . In underdeveloped countries carcinoma of the cervix is widespread and often the most frequent tumour [ 18 ] . Besides primarily surgical treatment radiotherapy is the main curative treatment modality , the 5-year survival rates after therapy being around 90% for stage I disease and 7% for stage IV ( FIGO Annual Report ) . It therefore seems desirable to look for therapeutic concepts , with the aim of improving the present results further by means of new combinations of irradiation with a systemic therapy ." ], "offsets": [ [ 0, 737 ] ] } ]

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"DerGynaekologe.90320306.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "surgical" ], "offsets": [ [ 354, 362 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "DerGynaekologe.90320306.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 363, 372 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerGynaekologe.90320306.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "radiotherapy" ], "offsets": [ [ 373, 385 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034618" }, { "db_name": "UMLS", "db_id": "C0034619" } ] }, { "id": "DerGynaekologe.90320306.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 407, 416 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerGynaekologe.90320306.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "survival" ], "offsets": [ [ 439, 447 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"normalized": [ { "db_name": "UMLS", "db_id": "C0034618" }, { "db_name": "UMLS", "db_id": "C0851346" } ] }, { "id": "DerGynaekologe.90320306.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 728, 735 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] } ]

[]

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DerGynaekologe.90320312.eng.abstr

[ { "id": "DerGynaekologe.90320312.eng.abstr-passage-0", "type": "abstract", "text": [ "Approximately one out of every three patients with carcinoma of the cervix must be expected to experience a recurrence . The treatment of such relapses is dependent on the site and extension of the recurrence , the type of primary therapy administered and the patient's general condition . The limit conditions for the application of the established forms of therapy available - surgical operation , radiotherapy , chemotherapy - are complex and seldom documented by randomized studies . In general , empiric observations and historical analyses determine the backdrop against which therapy is planned . The main experiences available are compiled in this paper to give a basis for individual treatment of patients with recurrences ." ], "offsets": [ [ 0, 733 ] ] } ]

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[]

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DerGynaekologe.90320322.eng.abstr

[ { "id": "DerGynaekologe.90320322.eng.abstr-passage-0", "type": "abstract", "text": [ "Up to the middle of the 1970s , chemotherapy had only a marginal role in the overall treatment concept for cervical carcinoma , and surgery and radiotherapy are still the cornerstones of treatment today . There are indications for chemotherapy , which can theoretically be used as follows :" ], "offsets": [ [ 0, 290 ] ] } ]

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[]

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DerGynaekologe.90320354.eng.abstr

[ { "id": "DerGynaekologe.90320354.eng.abstr-passage-0", "type": "abstract", "text": [ "An adequate increase of uterine blood flow throughout gestation is essential for uterine , placental and fetal growth . Maternal cardiovascular adaptation has to provide the uterine perfusion that is necessary to meet the requirements of the developing and growing fetus by providing transport of nutrients and oxygen to the placenta and the fetus . Thus uterine blood flow is inextricably linked to fetal growth and survival . Reductions of uterine blood flow can occur under acute or chronic conditions or in a combination of both . Chronic reductions of uterine blood flow can be observed in pregnancy induced hyertension ( PIH ) , diabetes mellitus in pregnancy and intrauterine growth restriction ( IUGR ) . Chronic restrictions in uterine blood flow will elicit a placental and fetal response in the form of growth adaptation to the reduced supply of oxygen and nutrients to the conceptus . If compensatory growth restriction reaches its limits intrauterine fetal distress can ensue ." ], "offsets": [ [ 0, 990 ] ] } ]

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[]

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"DerGynaekologe.90320354.eng.abstr-s6-t5", "normalized": [] }, { "id": "DerGynaekologe.90320354.eng.abstr-s6-r11-t2.1-t1.2", "type": "produces", "arg1_id": "DerGynaekologe.90320354.eng.abstr-s7-t2", "arg2_id": "DerGynaekologe.90320354.eng.abstr-s7-t1", "normalized": [] }, { "id": "DerGynaekologe.90320354.eng.abstr-s6-r12-t5.1-t3.2", "type": "affects", "arg1_id": "DerGynaekologe.90320354.eng.abstr-s6-t5", "arg2_id": "DerGynaekologe.90320354.eng.abstr-s6-t3", "normalized": [] }, { "id": "DerGynaekologe.90320354.eng.abstr-s6-r14-t1.1-t3.2", "type": "location_of", "arg1_id": "DerGynaekologe.90320354.eng.abstr-s7-t1", "arg2_id": "DerGynaekologe.90320354.eng.abstr-s6-t3", "normalized": [] }, { "id": "DerGynaekologe.90320354.eng.abstr-s6-r15-t6.2-t2.1", "type": "uses", "arg1_id": "DerGynaekologe.90320354.eng.abstr-s6-t6", "arg2_id": "DerGynaekologe.90320354.eng.abstr-s7-t2", "normalized": [] } ]

DerGynaekologe.90320360.eng.abstr

[ { "id": "DerGynaekologe.90320360.eng.abstr-passage-0", "type": "abstract", "text": [ "To test the hypothesis that cardiovascular adaptations to human pregnancy begin in the first 4 weeks post ovulation ( PO ) we obtained estimates of resting heart rate ( HR ) , blood pressure ( BP ) , stroke volume ( SV ) , cardiac output ( CO ) , peripheral resistance ( TPR ) , and venous capacity ( VC ) and compliance ( VCom ) weekly under standard conditions beginning on day 3 of the menstrual cycle . The data obtained in cycles with conception were compared to those in which conception did not occur . Techniques utilized included EKG , automated blood pressure measurement ( Dynamap ) , echocardiography , and plethysmography . No directional changes were observed in any parameter during the cycles in which conception did not occur . However , in cycles in which conception occurred HR increased 10 bpm within 1 week PO and remained at that level for the next 7 weeks . BP did not fall significantly until the 5th week PO . SV rose significantly between the 2nd and 3rd week PO and plateaued 10 % above pre ovulatory levels thereafter . As a result , CO rose and TPR fell significantly within 1 week PO and plateaued 1.5 l/min above and 300 dyne/cm/s-5 below pre ovulatory levels by the 3rd PO week . VC increased and followed a similar time course . These changes were associated with rapid increases in human chorionic gonadotropin , a fourfold increase in estradiol , and a twofold increase in progesterone . We conclude that the hypothesis is correct and speculate that the cardiovascular changes are initiated by the rapidly changing hormonal milieu ." ], "offsets": [ [ 0, 1567 ] ] } ]

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[]

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DerGynaekologe.90320367.eng.abstr

[ { "id": "DerGynaekologe.90320367.eng.abstr-passage-0", "type": "abstract", "text": [ "The increase in cardiac output during pregnancy depends on the increase of preload due to increase of blood volume and reduction of afterload due to reduction of systemic vessel resistance . This increase in stroke volume in the course of pregnancy and its normalization after delivery can be measured by means of Doppler ultrasound either as systolic peak velocity or as time-velocity integral ." ], "offsets": [ [ 0, 396 ] ] } ]

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[]

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"DerGynaekologe.90320367.eng.abstr-s2-t7", "normalized": [] }, { "id": "DerGynaekologe.90320367.eng.abstr-s2-r37-t4.1-t7.1", "type": "measures", "arg1_id": "DerGynaekologe.90320367.eng.abstr-s2-t4", "arg2_id": "DerGynaekologe.90320367.eng.abstr-s2-t7", "normalized": [] }, { "id": "DerGynaekologe.90320367.eng.abstr-s2-r38-t1.1-t6.1", "type": "associated_with", "arg1_id": "DerGynaekologe.90320367.eng.abstr-s2-t1", "arg2_id": "DerGynaekologe.90320367.eng.abstr-s2-t6", "normalized": [] }, { "id": "DerGynaekologe.90320367.eng.abstr-s2-r39-t6.1-t1.1", "type": "associated_with", "arg1_id": "DerGynaekologe.90320367.eng.abstr-s2-t6", "arg2_id": "DerGynaekologe.90320367.eng.abstr-s2-t1", "normalized": [] }, { "id": "DerGynaekologe.90320367.eng.abstr-s2-r40-t2.1-t1.1", "type": "result_of", "arg1_id": "DerGynaekologe.90320367.eng.abstr-s2-t2", "arg2_id": "DerGynaekologe.90320367.eng.abstr-s2-t1", "normalized": [] }, { "id": "DerGynaekologe.90320367.eng.abstr-s2-r42-t1.1-t4.1", "type": "associated_with", "arg1_id": "DerGynaekologe.90320367.eng.abstr-s2-t1", "arg2_id": "DerGynaekologe.90320367.eng.abstr-s2-t4", "normalized": [] }, { "id": "DerGynaekologe.90320367.eng.abstr-s2-r43-t7.1-t3.1", "type": "precedes", "arg1_id": "DerGynaekologe.90320367.eng.abstr-s2-t7", "arg2_id": "DerGynaekologe.90320367.eng.abstr-s2-t3", "normalized": [] }, { "id": "DerGynaekologe.90320367.eng.abstr-s2-r44-t1.1-t3.1", "type": "associated_with", "arg1_id": "DerGynaekologe.90320367.eng.abstr-s2-t1", "arg2_id": "DerGynaekologe.90320367.eng.abstr-s2-t3", "normalized": [] }, { "id": "DerGynaekologe.90320367.eng.abstr-s2-r45-t4.1-t6.1", "type": "measures", "arg1_id": "DerGynaekologe.90320367.eng.abstr-s2-t4", "arg2_id": "DerGynaekologe.90320367.eng.abstr-s2-t6", "normalized": [] } ]

DerGynaekologe.90320386.eng.abstr

[ { "id": "DerGynaekologe.90320386.eng.abstr-passage-0", "type": "abstract", "text": [ "In daily obstetrical practice there is an increasing need on information about questions regarding lifestyle during pregnancy . The concern , discussion and knowledge however , exist since early times of medical history ( e . g . Hippocrates 480 BC ) . The subject \" floats \" between physiological changes caused by gestational alterations and needs on the one hand and - on the other hand - the effects of physical activities ." ], "offsets": [ [ 0, 428 ] ] } ]

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[]

[ { "id": "DerGynaekologe.90320386.eng.abstr-s2-r1-t1.1-t3.1", "type": "issue_in", "arg1_id": "DerGynaekologe.90320386.eng.abstr-s5-t1", "arg2_id": "DerGynaekologe.90320386.eng.abstr-s2-t3", "normalized": [] }, { "id": "DerGynaekologe.90320386.eng.abstr-s2-r3-t2.1-t3.1", "type": "issue_in", "arg1_id": "DerGynaekologe.90320386.eng.abstr-s5-t2", "arg2_id": "DerGynaekologe.90320386.eng.abstr-s2-t3", "normalized": [] } ]

DerGynaekologe.90320426.eng.abstr

[ { "id": "DerGynaekologe.90320426.eng.abstr-passage-0", "type": "abstract", "text": [ "The mean arterial blood pressure is decreased during the first two trimesters of pregnancy and increases to preconceptional values during the last weeks of gestation . The heart rate increases during the whole course of pregnancy . During late gestation fewer patients show an increase in diastolic blood pressure and heart rate in the standing position . A fall in heart rate was only seen in this period . A fall in mean arterial blood pressure during standing is not related to the blood pressure in the supine position during the whole course of pregnancy . The hypotensive symptoms are twice as frequent during early pregnancy compared to late pregnancy . Headaches , fatigue and cold extremities are the most usual complaints . The frequency and intensity of these three symptoms decrease during gestation . Blood pressure in the supine position is reduced in symptomatic pregnant women . However , the occurrence of these symptoms is not correlated to the fall in blood pressure in the standing position . The Birth-weight is not influenced by blood pressure in the supine position , but depends on the fall in blood pressure during standing . Pregnant women with a more pronounced fall in blood pressure give birth to newborns with a lower birthweight . These results imply a hitherto unknown cause of intrauterine growth restriction ." ], "offsets": [ [ 0, 1343 ] ] } ]

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"db_id": "C0005823" }, { "db_name": "UMLS", "db_id": "C0005824" } ] }, { "id": "DerGynaekologe.90320426.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "heart" ], "offsets": [ [ 172, 177 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018787" } ] }, { "id": "DerGynaekologe.90320426.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "pregnancy" ], "offsets": [ [ 220, 229 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "DerGynaekologe.90320426.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "heart rate" ], "offsets": [ [ 172, 182 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018810" } ] }, { "id": "DerGynaekologe.90320426.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 260, 268 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerGynaekologe.90320426.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "blood" ], "offsets": [ [ 299, 304 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005767" 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"blood" ], "offsets": [ [ 485, 490 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005767" }, { "db_name": "UMLS", "db_id": "C0005768" }, { "db_name": "UMLS", "db_id": "C0005835" } ] }, { "id": "DerGynaekologe.90320426.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "pressure" ], "offsets": [ [ 491, 499 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033095" } ] }, { "id": "DerGynaekologe.90320426.eng.abstr-s5-t5", "type": "umlsterm", "text": [ "pregnancy" ], "offsets": [ [ 550, 559 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "DerGynaekologe.90320426.eng.abstr-s5-t6", "type": "umlsterm", "text": [ "blood pressure" ], "offsets": [ [ 432, 446 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005823" }, { "db_name": "UMLS", "db_id": "C0005824" } ] }, { "id": "DerGynaekologe.90320426.eng.abstr-s5-t7", "type": "umlsterm", "text": [ "blood pressure" ], "offsets": [ [ 485, 499 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005823" }, { 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"id": "DerGynaekologe.90320426.eng.abstr-s7-t2", "type": "umlsterm", "text": [ "fatigue" ], "offsets": [ [ 673, 680 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015672" } ] }, { "id": "DerGynaekologe.90320426.eng.abstr-s7-t3", "type": "umlsterm", "text": [ "cold" ], "offsets": [ [ 685, 689 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009443" }, { "db_name": "UMLS", "db_id": "C0010412" }, { "db_name": "UMLS", "db_id": "C0024117" }, { "db_name": "UMLS", "db_id": "C0009264" } ] }, { "id": "DerGynaekologe.90320426.eng.abstr-s7-t4", "type": "umlsterm", "text": [ "extremities" ], "offsets": [ [ 690, 701 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015385" } ] }, { "id": "DerGynaekologe.90320426.eng.abstr-s8-t1", "type": "umlsterm", "text": [ "frequency" ], "offsets": [ [ 738, 747 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376249" } ] }, { "id": "DerGynaekologe.90320426.eng.abstr-s8-t2", "type": "umlsterm", "text": [ "symptoms" ], "offsets": [ [ 777, 785 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[]

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DerGynaekologe.90320432.eng.abstr

[ { "id": "DerGynaekologe.90320432.eng.abstr-passage-0", "type": "abstract", "text": [ "Hypertensive diseases in pregnancy ( HDP ) are one of the most frequent causes of maternal death and perinatal mortality . However , chronic hypertension without complications has a more favorable prognosis than preeclampsia . Apart from a familial predisposition , mutations of various genes may also be responsible ; among these , APC resistance is of particular clinical significance . The insufficient endovascular invasion of trophoblast in the spiral aterioles is still considered to represent the pathogenetic basis of preeclampsia . Increased lipid oxidation , deported membrane components of syncytiotrophoblasts , and increased invasion of fetal cells in the maternal circulation triggering immunological reactions are discussed as the causes . The result is an endothelial imbalance between vasoconstrictory-aggregating and vasodilatatory-antiaggregating compounds . The results of studies on the relevance of NO synthase are controversial . Currently , neither reliable methods for the early detection nor certain preventative measures to avoid the disease are available . Intensive care monitoring and therapy are essential for pregnant women with severe HDP . The obstetric procedure depends on the severity and dynamics of the disease as well as the state of development of the baby . When the pregnancy is continued defined guidelines for its termination for maternal or fetal indications must be taken into consideration . After delivery , the mother must be intensively monitored for at least 24 to 48 hours ( postpartal eclampsia/HELLP syndrome ) . The risk for recurrence of the preeclampsia is between 20 and 26 % or when it occurred in the second trimester up to 65 % while that of HELLP syndrome is between 3.5 and 24 % ." ], "offsets": [ [ 0, 1744 ] ] } ]

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[]

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"result_of", "arg1_id": "DerGynaekologe.90320432.eng.abstr-s13-t2", "arg2_id": "DerGynaekologe.90320432.eng.abstr-s13-t6", "normalized": [] }, { "id": "DerGynaekologe.90320432.eng.abstr-s13-r5-t3.1-t2.1", "type": "result_of", "arg1_id": "DerGynaekologe.90320432.eng.abstr-s13-t3", "arg2_id": "DerGynaekologe.90320432.eng.abstr-s13-t2", "normalized": [] }, { "id": "DerGynaekologe.90320432.eng.abstr-s13-r6-t4.1-t2.1", "type": "result_of", "arg1_id": "DerGynaekologe.90320432.eng.abstr-s13-t4", "arg2_id": "DerGynaekologe.90320432.eng.abstr-s13-t2", "normalized": [] } ]

DerGynaekologe.90320450.eng.abstr

[ { "id": "DerGynaekologe.90320450.eng.abstr-passage-0", "type": "abstract", "text": [ "Cardiac transplantation ( HTX ) is accepted as an effective treatment for some end-stage cardiac diseases . Maternal risks during pregnancies after HTX include : hypertension , allograft rejection , infections and renal insufficiency . Potential risks to the fetus include side effects of immunosuppressives , preterm delivery and growth restriction . Pregnancies in cardiac transplant recipients should be considered high risk . This review demonstrates the variety of problems concerning pregnancy and delivery after HTX to help the doctor to advise these patients ." ], "offsets": [ [ 0, 568 ] ] } ]

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], "offsets": [ [ 89, 105 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018799" } ] }, { "id": "DerGynaekologe.90320450.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "risks" ], "offsets": [ [ 117, 122 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "DerGynaekologe.90320450.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "pregnancies" ], "offsets": [ [ 130, 141 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "DerGynaekologe.90320450.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "hypertension" ], "offsets": [ [ 162, 174 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020538" } ] }, { "id": "DerGynaekologe.90320450.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "rejection" ], "offsets": [ [ 187, 196 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035015" } ] }, { "id": "DerGynaekologe.90320450.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "infections" ], "offsets": [ [ 199, 209 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021311" } ] }, { "id": "DerGynaekologe.90320450.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "renal insufficiency" ], "offsets": [ [ 214, 233 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035078" } ] }, { "id": "DerGynaekologe.90320450.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "risks" ], "offsets": [ [ 246, 251 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "DerGynaekologe.90320450.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "fetus" ], "offsets": [ [ 259, 264 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015965" } ] }, { "id": "DerGynaekologe.90320450.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "immunosuppressives" ], "offsets": [ [ 289, 307 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021081" } ] }, { "id": "DerGynaekologe.90320450.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "delivery" ], "offsets": [ [ 318, 326 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011209" } ] }, { "id": "DerGynaekologe.90320450.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "growth" ], "offsets": [ [ 331, 337 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018270" }, { "db_name": "UMLS", "db_id": "C0220844" } ] }, { "id": "DerGynaekologe.90320450.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "side effects" ], "offsets": [ [ 273, 285 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001688" } ] }, { "id": "DerGynaekologe.90320450.eng.abstr-s3-t7", "type": "umlsterm", "text": [ "preterm delivery" ], "offsets": [ [ 310, 326 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0151526" } ] }, { "id": "DerGynaekologe.90320450.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "Pregnancies" ], "offsets": [ [ 352, 363 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "DerGynaekologe.90320450.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "transplant" ], "offsets": [ [ 375, 385 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0332835" }, { "db_name": "UMLS", "db_id": "C0040733" } ] }, { "id": "DerGynaekologe.90320450.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "risk" ], "offsets": [ [ 423, 427 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "DerGynaekologe.90320450.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "cardiac transplant" ], "offsets": [ [ 367, 385 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018823" } ] }, { "id": "DerGynaekologe.90320450.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "transplant recipients" ], "offsets": [ [ 375, 396 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376387" } ] }, { "id": "DerGynaekologe.90320450.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "review" ], "offsets": [ [ 435, 441 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0282443" } ] }, { "id": "DerGynaekologe.90320450.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "pregnancy" ], "offsets": [ [ 490, 499 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "DerGynaekologe.90320450.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "delivery" ], "offsets": [ [ 504, 512 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011209" } ] }, { "id": "DerGynaekologe.90320450.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "doctor" ], "offsets": [ [ 535, 541 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031831" } ] }, { "id": "DerGynaekologe.90320450.eng.abstr-s5-t5", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 558, 566 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] } ]

[]

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DerGynaekologe.90320455.eng.abstr

[ { "id": "DerGynaekologe.90320455.eng.abstr-passage-0", "type": "abstract", "text": [ "Question : What risks do different forms of immunosuppression ( azathioprine , Cyclosporin , azathioprine/Cyclosporin plus steroids ) represent in pregnancy for the mother and fetus after kidney transplantation ? Retrospective analysis of 40 pregnancies and deliveries . Investigation of abortion - , premature birth rate , fetal retardation , malformation , hospitalization , modus of labour , birth weight , gestational age , perinatal mortality , hypertonia , preeclampsia , anemia , kidney function , rejection crisis , mechanical compression , kidney function after 1 and 5 years postpartum . Recommendation guideline : preconceptional time ( contraception ) and intensive care in pregnancy . The risk of pregnancy is justified if the presuppositions are correct and the woman would urgently like to have a child ." ], "offsets": [ [ 0, 819 ] ] } ]

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[]

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"normalized": [] }, { "id": "DerGynaekologe.90320455.eng.abstr-s5-r4-t2.1-t4.1", "type": "produces", "arg1_id": "DerGynaekologe.90320455.eng.abstr-s5-t2", "arg2_id": "DerGynaekologe.90320455.eng.abstr-s5-t4", "normalized": [] }, { "id": "DerGynaekologe.90320455.eng.abstr-s5-r5-t1.1-t2.1", "type": "measurement_of", "arg1_id": "DerGynaekologe.90320455.eng.abstr-s5-t1", "arg2_id": "DerGynaekologe.90320455.eng.abstr-s5-t2", "normalized": [] } ]

DerGynaekologe.90320496.eng.abstr

[ { "id": "DerGynaekologe.90320496.eng.abstr-passage-0", "type": "abstract", "text": [ "Even if Ignaz Philipp Semmelweis has not found the true aetiology of puerperal fever - bacteria were identified as pathogens only after his observations - he was the first to consequently use epidemiological methods in order to elucidate connections and influencing factors in the spread of nosocomial infections , to draw the right conclusions from his observations on the transmission of childbed fever and to draw the right consequences by implementing preventive measures , especially the hand disinfection . He has correctly realized that human beings suffering from purulent or putride lesions or having even died from them can act as infectious sources as can hands of health-care personnel act as vehicles . As a characteristic feature of nosocomial infection , he noticed that generally only the weakend organism of the patient is involved as an infection target . The impact of his doctrine not only made him \" saviour of the mothers \" but also justifies to regard him as \" father of the obstetric infection prevention \" if not even as the founder of the modern science-based hospital hygiene ." ], "offsets": [ [ 0, 1104 ] ] } ]

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DerGynaekologe.90320501.eng.abstr

[ { "id": "DerGynaekologe.90320501.eng.abstr-passage-0", "type": "abstract", "text": [ "Septic abortion remains one of the most serious threats to the health and life of women throughout the world . Morbidity and mortality are infrequent in countries where induced abortion is legal and medically well organized , but widespread in many developing countries where it is either illegal or inaccessible ." ], "offsets": [ [ 0, 314 ] ] } ]

[ { "id": "DerGynaekologe.90320501.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "abortion" ], "offsets": [ [ 7, 15 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000786" }, { "db_name": "UMLS", "db_id": "C0000811" } ] }, { "id": "DerGynaekologe.90320501.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "health" ], "offsets": [ [ 63, 69 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018684" } ] }, { "id": "DerGynaekologe.90320501.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "life" ], "offsets": [ [ 74, 78 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376558" } ] }, { "id": "DerGynaekologe.90320501.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "women" ], "offsets": [ [ 82, 87 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043210" } ] }, { "id": "DerGynaekologe.90320501.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "Septic abortion" ], "offsets": [ [ 0, 15 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000817" } ] }, { "id": "DerGynaekologe.90320501.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "Morbidity" ], "offsets": [ [ 111, 120 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220880" }, { "db_name": "UMLS", "db_id": "C0026538" } ] }, { "id": "DerGynaekologe.90320501.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "mortality" ], "offsets": [ [ 125, 134 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026566" }, { "db_name": "UMLS", "db_id": "C0026565" } ] }, { "id": "DerGynaekologe.90320501.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "abortion" ], "offsets": [ [ 177, 185 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000786" }, { "db_name": "UMLS", "db_id": "C0000811" } ] }, { "id": "DerGynaekologe.90320501.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "induced abortion" ], "offsets": [ [ 169, 185 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000811" } ] }, { "id": "DerGynaekologe.90320501.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "developing countries" ], "offsets": [ [ 249, 269 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011750" } ] } ]

[]

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DerGynaekologe.90320507.eng.abstr

[ { "id": "DerGynaekologe.90320507.eng.abstr-passage-0", "type": "abstract", "text": [ "Chorioamnionitis has to be considered a uterine infection while the fetus remains inside . Ascending aerobe and anaerobe bacteria are mainly responsible for chorioamnionitis . Amniotic inflammation occurs in 2-4 % of all pregnancies . Women with preterm deliveries and premature rupture of the membrane have an increased risk for developing chorioamnionitis . The published infection rate of the uterus cavity ranges from 10 to 50 % . In 5-10 % of threatened preterm births the intrauterine infection is detectable . Currently , simple test systems are available for analyses of gram-positive bacteria , leukocyte number , cytokines and concentration of glucose in the amniotic fluid completed by cultures for bacteria . The signs and symptoms of chorioamnionitis include elevated maternal temperature ( oral 37.5 °C; rectal 38.0 °C), fetal or maternal tachycardia , and uterine contractions or tenderness . The C-reactive protein ( CRP ) is still the best serum parameter to predict amniotic infection . The two major problems of amniotic inflammation are septic shock for the mother and involvement of the placenta and fetus . To prevent these complications high-dose antibiotics are necessary and immediate delivery should be considered . The local and systemic spread is due to delayed diagnosis and may present as myometritis , endomyometritis , peritonitis , bacteremia , septic pneumonia or shock lung . Additionally , an infection of group B streptococci increases the risk for development of maternal meningitis ." ], "offsets": [ [ 0, 1522 ] ] } ]

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[]

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"DerGynaekologe.90320507.eng.abstr-s13-t6", "normalized": [] }, { "id": "DerGynaekologe.90320507.eng.abstr-s13-r16-t5.1-t6.1", "type": "affects", "arg1_id": "DerGynaekologe.90320507.eng.abstr-s13-t5", "arg2_id": "DerGynaekologe.90320507.eng.abstr-s13-t6", "normalized": [] } ]

DerGynaekologe.90320518.eng.abstr

[ { "id": "DerGynaekologe.90320518.eng.abstr-passage-0", "type": "abstract", "text": [ "Sepsis developing on the basis of a postoperative infection is a rare , but life-threatening event . Early diagnosis of postoperative complications usually facilitates decisive intervention and a favorable prognosis . If the right moment is missed , endothelial damage leads to the release of inflammatory mediators and generalized systemic infection ( SIRS ) . For the subsequentially developing septic shock , often combined with multiple organ failure ( MOF ) , it is not important whether the starting point was an uncontrollable infections focus , ischemic damage following hypovolemic shock , or massive bacterial translocation with postoperative bowel obstruction . The collapse of the immune system results in immune paralysis and explains the inability of the organism to defend itself against systemic infections . For early recognition of the developing septic complication and its effective treatment , pathophysiological and clinical issues are discussed ." ], "offsets": [ [ 0, 969 ] ] } ]

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"text": [ "postoperative" ], "offsets": [ [ 639, 652 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032790" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s4-t8", "type": "umlsterm", "text": [ "bowel" ], "offsets": [ [ 653, 658 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021853" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s4-t9", "type": "umlsterm", "text": [ "septic shock" ], "offsets": [ [ 397, 409 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036983" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s4-t10", "type": "umlsterm", "text": [ "hypovolemic shock" ], "offsets": [ [ 579, 596 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020683" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s4-t11", "type": "umlsterm", "text": [ "bacterial translocation" ], "offsets": [ [ 610, 633 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0282583" } ] }, { "id": "DerGynaekologe.90320518.eng.abstr-s4-t12", "type": "umlsterm", "text": [ "bowel 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[]

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DerGynaekologe.90320529.eng.abstr

[ { "id": "DerGynaekologe.90320529.eng.abstr-passage-0", "type": "abstract", "text": [ "Chemotherapy-induced febrile neutropenia makes the immuncompromized cancer patient even more susceptible to severe infections . The risk of infections correlates with grade and duration of febrile neutropenia . Empiric antibiotic treatment can diminish the high infection-associated mortality . There are guidelines for antimicrobial treatment and modifications of therapy . To individualize therapy decisions , it is helpful to characterize high- and low-risk patients . Antibiotic prophylaxis in afebrile neutropenic patients is only indicated in special cases . Use of G-CSF for prophylaxis of neutropenia can be recommended for high-risk patients , but it should not be used for the treatment of infection ." ], "offsets": [ [ 0, 711 ] ] } ]

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"offsets": [ [ 565, 568 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042153" } ] }, { "id": "DerGynaekologe.90320529.eng.abstr-s7-t2", "type": "umlsterm", "text": [ "G-CSF" ], "offsets": [ [ 572, 577 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0079459" } ] }, { "id": "DerGynaekologe.90320529.eng.abstr-s7-t3", "type": "umlsterm", "text": [ "prophylaxis" ], "offsets": [ [ 582, 593 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033107" } ] }, { "id": "DerGynaekologe.90320529.eng.abstr-s7-t4", "type": "umlsterm", "text": [ "neutropenia" ], "offsets": [ [ 597, 608 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027947" } ] }, { "id": "DerGynaekologe.90320529.eng.abstr-s7-t5", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 642, 650 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerGynaekologe.90320529.eng.abstr-s7-t6", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 687, 696 ] ], "normalized": [ { 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[]

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"indicates", "arg1_id": "DerGynaekologe.90320529.eng.abstr-s7-t1", "arg2_id": "DerGynaekologe.90320529.eng.abstr-s7-t6", "normalized": [] }, { "id": "DerGynaekologe.90320529.eng.abstr-s7-r12-t6.1-t3.1", "type": "associated_with", "arg1_id": "DerGynaekologe.90320529.eng.abstr-s7-t6", "arg2_id": "DerGynaekologe.90320529.eng.abstr-s7-t3", "normalized": [] }, { "id": "DerGynaekologe.90320529.eng.abstr-s7-r13-t3.1-t1.1", "type": "produces", "arg1_id": "DerGynaekologe.90320529.eng.abstr-s7-t3", "arg2_id": "DerGynaekologe.90320529.eng.abstr-s7-t1", "normalized": [] }, { "id": "DerGynaekologe.90320529.eng.abstr-s7-r14-t6.1-t5.1", "type": "occurs_in", "arg1_id": "DerGynaekologe.90320529.eng.abstr-s7-t6", "arg2_id": "DerGynaekologe.90320529.eng.abstr-s7-t5", "normalized": [] } ]

DerGynaekologe.90320540.eng.abstr

[ { "id": "DerGynaekologe.90320540.eng.abstr-passage-0", "type": "abstract", "text": [ "HIV infected women have an increased morbidity caused by acute and chronic urogenital infections and their sequels . Up to 2/3 of the patients develop symptoms of genital infections and in around 1/3 cervical neoplasia is diagnosed . In 1/4 chronic lower abdominal discomfort and late sequels of PID will arise . Although cervical carcinoma ( - 5 % ) fulfills already the AIDS definition , it manifests usually early in the course of the HIV disease and is rarely associated with other opportunistic diseases . Increased disturbances of menstruation like amenorrhoea ( 17 % ) or hypermenorrhoea has been observed . Major complication of prenancy are preterm labor ( - 15 % ) and preterm delivery . An increased progression of the maternal HIV disease in association with pregnancy has not been observed . Risks of perinatal HIV-1 infection of the fetus are associated either with an already advanced or progressing HIV infection of the mother indicated by high viral load , p24 antigenemia and low CD4+ cells or obstetrical events like preterm delivery , preterm labor , amnionitis , duration of rupture of membranes and labor and contamination of amniotic fluid with maternal blood . Maternofetal HIV-1 transmission can be reduced by antiretroviral prophylaxis of the mother and the fetus ( 6-8 % ) , by elective caesarian ( 4-6 % ) or most successfully by elective caesarian and antiretroviral prophylaxis ( 2 % ) ." ], "offsets": [ [ 0, 1417 ] ] } ]

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[]

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DerGynaekologe.90320552.eng.abstr

[ { "id": "DerGynaekologe.90320552.eng.abstr-passage-0", "type": "abstract", "text": [ "In the late seventies and early eighties the toxic shock syndrome ( TSS ) became epidemic among young menstruating women . A strong correlation was found between TSS and the rising popularity of hyperabsorbent tampons . Exotoxin-producing Staphylococcus aureus is seen as the main mediator of TSS in controlled clinical trials . Menstrual and nonmenstrual forms of TSS are differentiated . The nonmenstrual form is comparatively rare and has a high rate of mortality rate . Several studies showed that the overall incidence of menstrual and nonmenstrual TSS is approximately 1-3 cases per 100 000 persons . The leading symptoms are fever , hypotension , mucous membrane hyperemia , diffuse rashes , myalgias , vomiting and diarrhea . The severe form of the syndrome leads to multiorgan dysfunction . The streptococcal TSS ( STSS ) caused by group A Streptococci is clinically similar to the staphylococcal TSS . Both Staphylococcus aureus and Streptococci produce the exotoxin TSST-1. New methods allow the detection of TSST-1 production . However , due to the low incidence of TSS , this method of detection has not yet been taken up in the routine diagnostic procedures ." ], "offsets": [ [ 0, 1173 ] ] } ]

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[]

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DerGynaekologe.90320594.eng.abstr

[ { "id": "DerGynaekologe.90320594.eng.abstr-passage-0", "type": "abstract", "text": [ "In adjuvant therapy of breast cancer , instead of individualized chemotherapy regimens there is a tendency towards more aggressive protocols in patients with high risk of recurrence . In this context even therapy-related mortality is accepted because therapy may be curative . In contrast , chemotherapy for metastatic disease mainly aims at palliation . Reduction of therapy-related side effects is one of the major endpoints of clinical trials in stage IV breast cancer . Routine follow-up procedures that do not aim at early diagnosis of metastatic disease , but at the diagnosis of symptomatic metastases , further reflect this therapeutic strategy . During recent years this paradigm has been challenged by two new developments . On the one hand , new therapies like high-dose chemotherapy with stem-cell support may allow long-term survival for certain subgroups of patients with metastatic disease . On the other hand , the refinement of diagnostic procedures may allow \" metastatic disease \" to be detected in breast cancer that , according to TNM staging , is classified as early breast cancer . This and the concept of \" micrometastases \" that are treated by adjuvant therapy imply that by conventional staging with chest X-ray , liver ultrasound and bone scans somehow artificially two different stages of the same disease are defined . Even if the biology of metastasis or the refinement of diagnostic procedures is of great interest , routine therapeutic strategies must be guided by the results from clinical trials that mainly deal with metastatic breast cancer as defined by conventional staging procedures . Every modification of this definition , even if it reflects more intimate understanding of the disease , must be evaluated in prospective randomized clinical trials ." ], "offsets": [ [ 0, 1791 ] ] } ]

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[]

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DerGynaekologe.90320597.eng.abstr

[ { "id": "DerGynaekologe.90320597.eng.abstr-passage-0", "type": "abstract", "text": [ "In 10-30 % of cases , locoregional recurrence is accompanied by distant metastasis ; a further 25 % develop distant metastasis within the year after diagnosis of recurrence . In treatment of recurrent tumor in the thoracic wall , axillary or supraclavicular disease surgery plays a major role . Since - another long-lasting courses occur even in the metastatic situation , recurrence is not an infrequent event , and therapy then needs a multidisciplinary approach . Surgical techniques such as local , myocutaneous or omental flaps and mesh graft transplantation are used to cover large defects after tumor resection . Additional and innovative modalities are combined in the management of this complex problem : locoregional or systemic chemotherapy , topical application of chemotherapy , certain radiation regimens and in otherwise resistant tumors the experimental use of photodynamic laser therapy ( PDT ) . The most important goal hereby is to restore or at least maintain organ function and quality of life ." ], "offsets": [ [ 0, 1016 ] ] } ]

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[]

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DerGynaekologe.90320605.eng.abstr

[ { "id": "DerGynaekologe.90320605.eng.abstr-passage-0", "type": "abstract", "text": [ "There are plenty of endocrine agents available for patients with advanced breast cancer . They have good therapeutic evidence and show fewer side effects in women with hormone-receptor-positive tumors , as well as in a smaller percentage of patients with receptor negative tumors . Application of endocrine agents follows defined indications . They are given sequentially with the least toxic therapy given first . The suppression of estrogen synthesis with GnRH analogues is the first step of treatment for premenopausal patients . If the tumor progresses , the sequential application for premenopausal patients is the same as for postmenopausal women with continuous application of GnRH analogues . Antiestrogen tamoxifen is considered the first-line endocrine therapy for postmenopausal advanced breast cancer . Alternatively , Toremifen shows the same effectiveness and side effects as tamoxifen . Although it is postulated that is less carcinogenic , this must be demonstrated conclusively in long-term follow-up . The aromatase inhibitors are defined as second-line endocrine therapy . Newer selective aromatase inhibitors such as formestane , letrozole and anastrozole are p . o . active and have substituted classical aminoglutethimide . There are numerous new aromatase inhibitors that will be investigated in clinical trials of advanced and primary breast cancer . Progestins are given as third-line endocrine therapy . They have a high risk of thromboembolic complications , but good palliative and supportive effect . Antiprogestins , androgens and antiandrogens are still under investigation and have so far shown only limited success in clinical trials ." ], "offsets": [ [ 0, 1668 ] ] } ]

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[]

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DerGynaekologe.90320614.eng.abstr

[ { "id": "DerGynaekologe.90320614.eng.abstr-passage-0", "type": "abstract", "text": [ "The use of cytotoxic therapy in metastatic breast cancer is an effective , but quite toxic measure compared to other available treatment options . The decision for or against chemotherapy should take into account the patient , condition and the goals of the therapy . Aggressive therapies provide good remission rates and are suitable for patients with symptomatic disease and good performance status . Monotherapies are advantageous regarding tolerability and can often be conducted for a long time as consolidating therapy . Several new substances are efficient in breast-cancer patients and should be evaluated for further clinical use in future studies ." ], "offsets": [ [ 0, 658 ] ] } ]

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[]

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"DerGynaekologe.90320614.eng.abstr-s5-t1", "normalized": [] }, { "id": "DerGynaekologe.90320614.eng.abstr-s3-r2-t3.1-t1.1", "type": "occurs_in", "arg1_id": "DerGynaekologe.90320614.eng.abstr-s5-t3", "arg2_id": "DerGynaekologe.90320614.eng.abstr-s5-t1", "normalized": [] }, { "id": "DerGynaekologe.90320614.eng.abstr-s3-r3-t1.1-t3.1", "type": "associated_with", "arg1_id": "DerGynaekologe.90320614.eng.abstr-s5-t1", "arg2_id": "DerGynaekologe.90320614.eng.abstr-s5-t3", "normalized": [] }, { "id": "DerGynaekologe.90320614.eng.abstr-s5-r1-t1.1-t2.1", "type": "location_of", "arg1_id": "DerGynaekologe.90320614.eng.abstr-s5-t1", "arg2_id": "DerGynaekologe.90320614.eng.abstr-s5-t2", "normalized": [] } ]

DerGynaekologe.90320632.eng.abstr

[ { "id": "DerGynaekologe.90320632.eng.abstr-passage-0", "type": "abstract", "text": [ "Even today metastatic breast cancer remains incurable disease . Therefore most clinical trials in the last decade aimed at an improvement of the therapeutical ratio . In this context high-dose chemotherapy with therapy related mortality of 2 %-5 % seems to be justified only if long term survival or relevant prolongation of progression free survival is attainable . Survival data from early phase I-II trials show the same initial high relapse rates as after conventional chemotherapy . On the contrary , HDC data from the early 80 s suggest that after three years survival plateaus at 14 %-20 % long term survivors . Data from European and American transplant registries reporting about 4000 patients show the same trend . For the whole population the survival advantage by high dose chemotherapy is estimated to be about one year . Maximum benefit is demonstrable in patients with chemosensitive disease . Data from one phase III trial comparing early tandem HDC with conventional chemotherapy show significant survival advantages for the HDC group with 20 % survivors at 400 weeks . Data from other phase III trials will be published in 1999. In Germany patients can be randomized to two ongoing prospective randomized trials ." ], "offsets": [ [ 0, 1231 ] ] } ]

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"DerGynaekologe.90320632.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "clinical trials" ], "offsets": [ [ 79, 94 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008976" } ] }, { "id": "DerGynaekologe.90320632.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "chemotherapy" ], "offsets": [ [ 193, 205 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013216" }, { "db_name": "UMLS", "db_id": "C0013217" } ] }, { "id": "DerGynaekologe.90320632.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 211, 218 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerGynaekologe.90320632.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "mortality" ], "offsets": [ [ 227, 236 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026566" }, { "db_name": "UMLS", "db_id": "C0026565" } ] }, { "id": "DerGynaekologe.90320632.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "survival" ], "offsets": [ [ 288, 296 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220921" }, { "db_name": "UMLS", "db_id": "C0038952" } ] }, { "id": "DerGynaekologe.90320632.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "survival" ], "offsets": [ [ 342, 350 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220921" }, { "db_name": "UMLS", "db_id": "C0038952" } ] }, { "id": "DerGynaekologe.90320632.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "progression free survival" ], "offsets": [ [ 325, 350 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242792" } ] }, { "id": "DerGynaekologe.90320632.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "Survival" ], "offsets": [ [ 367, 375 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220921" }, { "db_name": "UMLS", "db_id": "C0038952" } ] }, { "id": "DerGynaekologe.90320632.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "chemotherapy" ], "offsets": [ [ 473, 485 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013216" }, { "db_name": "UMLS", "db_id": "C0013217" } ] }, { "id": "DerGynaekologe.90320632.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "survival" ], "offsets": [ [ 566, 574 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220921" }, { "db_name": "UMLS", "db_id": "C0038952" } ] }, { "id": "DerGynaekologe.90320632.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "survivors" ], "offsets": [ [ 607, 616 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0206194" } ] }, { "id": "DerGynaekologe.90320632.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "long term survivors" ], "offsets": [ [ 597, 616 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0206193" } ] }, { "id": "DerGynaekologe.90320632.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "transplant" ], "offsets": [ [ 651, 661 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0332835" }, { "db_name": "UMLS", "db_id": "C0040733" } ] }, { "id": "DerGynaekologe.90320632.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "registries" ], "offsets": [ [ 662, 672 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034975" } ] }, { "id": "DerGynaekologe.90320632.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 694, 702 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerGynaekologe.90320632.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "trend" ], "offsets": [ [ 717, 722 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040833" } ] }, { "id": "DerGynaekologe.90320632.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "population" ], "offsets": [ [ 739, 749 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032659" } ] }, { "id": "DerGynaekologe.90320632.eng.abstr-s7-t2", "type": "umlsterm", "text": [ "survival" ], "offsets": [ [ 754, 762 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220921" }, { "db_name": "UMLS", "db_id": "C0038952" } ] }, { "id": "DerGynaekologe.90320632.eng.abstr-s7-t3", "type": "umlsterm", "text": [ "chemotherapy" ], "offsets": [ [ 786, 798 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013216" }, { "db_name": "UMLS", "db_id": "C0013217" } ] }, { "id": "DerGynaekologe.90320632.eng.abstr-s8-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 870, 878 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerGynaekologe.90320632.eng.abstr-s8-t2", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 899, 906 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerGynaekologe.90320632.eng.abstr-s9-t1", "type": "umlsterm", "text": [ "tandem" ], "offsets": [ [ 955, 961 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0075804" } ] }, { "id": "DerGynaekologe.90320632.eng.abstr-s9-t2", "type": "umlsterm", "text": [ "chemotherapy" ], "offsets": [ [ 984, 996 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013216" }, { "db_name": "UMLS", "db_id": "C0013217" } ] }, { "id": "DerGynaekologe.90320632.eng.abstr-s9-t3", "type": "umlsterm", "text": [ "survival" ], "offsets": [ [ 1014, 1022 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220921" }, { "db_name": "UMLS", "db_id": "C0038952" } ] }, { "id": "DerGynaekologe.90320632.eng.abstr-s9-t4", "type": "umlsterm", "text": [ "survivors" ], "offsets": [ [ 1062, 1071 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0206194" } ] }, { "id": "DerGynaekologe.90320632.eng.abstr-s10-t1", "type": "umlsterm", "text": [ "Germany" ], "offsets": [ [ 1150, 1157 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017480" } ] }, { "id": "DerGynaekologe.90320632.eng.abstr-s10-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 1158, 1166 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] } ]

[]

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DerGynaekologe.90320660.eng.abstr

[ { "id": "DerGynaekologe.90320660.eng.abstr-passage-0", "type": "abstract", "text": [ "Prof. Gustav Adolph Michaelis ( 1798-1848 ) , director of the Obstetric Hospital and the School of Midwifery at Kiel/Germany , is known as one of the founders of scientific obstetrics . In research and teaching he was oriented towards empirical data . His most important scientific work on the narrow pelvis sums up his experience as an obstetrician . Pelvimetry and the inspection of the so-called \" Michaelis-rhomboid \" predict the prognosis of the process of birth . He was a conscientious researcher : he self-critically published unsuccessful cases and thoroughly considered new theories . In Germany he was the first to prove Semmelweis ' theory of the prophylaxis of puerperal sepsis to be true . When he realised that he had caused the death of so many women in childbirth , Michaelis was desperate and committed suicide in 1848." ], "offsets": [ [ 0, 837 ] ] } ]

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[]

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DerGynaekologe.90320666.eng.abstr

[ { "id": "DerGynaekologe.90320666.eng.abstr-passage-0", "type": "abstract", "text": [ "The liver is one of the most involved organs in the case of hematogenous metastases of breast carcinoma . In strictly intrahepatic involvement of breast cancer local ablative methods like surgical resection and minimal-invasive treatment modalities are discussed when systemic chemo- or hormone therapies are ineffective . In the clinical programme 51 patients with secondary metastastic involvement of the liver due to breast carcinoma were prospectively treated via MR-guided laser-induced thermotherapy in an outpatient setting . Patients were included with a maximum of five lesions up to a maximum diameter of 5 cm . Patients with additional extrahepatic involvement are excluded . MR-guided LITT allowed local tumor control in the liver at three months of 89.2 % and at six months of 79.1 % . The cumulative median survival rate was 50,29 months ( confidence interval 95 % , 41.99-42.22 months ) . MR-guided LITT allows high local tumor control . Possible indications for the treatment with LITT are patients with strictly intrahepatic metastases who are not demonstrating a complete response after chemo- or hormone therapy ." ], "offsets": [ [ 0, 1132 ] ] } ]

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"C0006141" }, { "db_name": "UMLS", "db_id": "C0006142" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "cancer" ], "offsets": [ [ 153, 159 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006826" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "methods" ], "offsets": [ [ 175, 182 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "surgical" ], "offsets": [ [ 188, 196 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 228, 237 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "hormone" ], "offsets": [ [ 287, 294 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019932" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s2-t7", "type": "umlsterm", "text": [ "therapies" ], "offsets": [ [ 295, 304 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s2-t8", "type": "umlsterm", "text": [ "breast cancer" ], "offsets": [ [ 146, 159 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006142" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 352, 360 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "secondary" ], "offsets": [ [ 366, 375 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027627" }, { "db_name": "UMLS", "db_id": "C0036525" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "liver" ], "offsets": [ [ 407, 412 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0345904" }, { "db_name": "UMLS", "db_id": "C0023884" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "breast" ], "offsets": [ [ 420, 426 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006141" }, { "db_name": "UMLS", "db_id": "C0006142" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "carcinoma" ], "offsets": [ [ 427, 436 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007097" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "thermotherapy" ], "offsets": [ [ 492, 505 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020548" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s3-t7", "type": "umlsterm", "text": [ "outpatient" ], "offsets": [ [ 512, 522 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029921" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "Patients" ], "offsets": [ [ 533, 541 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "Patients" ], "offsets": [ [ 622, 630 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "tumor" ], "offsets": [ [ 716, 721 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "control" ], "offsets": [ [ 722, 729 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243148" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "liver" ], "offsets": [ [ 737, 742 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0345904" }, { "db_name": "UMLS", "db_id": "C0023884" } ] }, { "id": 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"DerGynaekologe.90320666.eng.abstr-s9-t1", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 982, 991 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s9-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 1006, 1014 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s9-t3", "type": "umlsterm", "text": [ "metastases" ], "offsets": [ [ 1042, 1052 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027627" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s9-t4", "type": "umlsterm", "text": [ "hormone" ], "offsets": [ [ 1115, 1122 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019932" } ] }, { "id": "DerGynaekologe.90320666.eng.abstr-s9-t5", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 1123, 1130 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": 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[]

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DerGynaekologe.90320675.eng.abstr

[ { "id": "DerGynaekologe.90320675.eng.abstr-passage-0", "type": "abstract", "text": [ "Like other metastases , bone metastases in breast cancer patients are not only a sign of the incurable nature of the underlying disease , but are also associated with specific complications . In particular , bone pain and pathological fractures impair the quality of life of those affected . Any treatment concept must therefore place the highest priority on preventing or reducing skeletal complications . There are two treatment options - local and systemic . Local therapy includes radiotherapy as well as surgical and orthopedic measures . The four pillars of systemic treatment are hormone therapy and chemotherapy , antiresorptive therapy with bisphosphonates and treatment with centrally and/or peripherally acting analgesics . A precondition for successful treatment is close cooperation between gynecologists , internists/oncologists , radiotherapists , surgeons/orthopedists , pain specialists and endocrinologists ( in the presence of a hypercalcemic syndrome ) . Patients with breast cancer associated solely with osseous metastasis may survive for a number of years . It is therefore all the more important to start appropriate therapeutic measures in good time . Bisphosphonates play a particularly valuable role , since their main effect lies in the prevention of skeletal complications . Rather than replacing antineoplastic therapy , this class of substances supplements other treatments . Once started , bisphosphonate therapy should be given life-long , even in the event of osseous progression ." ], "offsets": [ [ 0, 1515 ] ] } ]

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[]

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"type": "uses", "arg1_id": "DerGynaekologe.90320675.eng.abstr-s11-t3", "arg2_id": "DerGynaekologe.90320675.eng.abstr-s12-t1", "normalized": [] }, { "id": "DerGynaekologe.90320675.eng.abstr-s11-r2-t2.1-t1.1", "type": "uses", "arg1_id": "DerGynaekologe.90320675.eng.abstr-s12-t2", "arg2_id": "DerGynaekologe.90320675.eng.abstr-s12-t1", "normalized": [] } ]

DerGynaekologe.90320683.eng.abstr

[ { "id": "DerGynaekologe.90320683.eng.abstr-passage-0", "type": "abstract", "text": [ "Brain metastases are life-threatening events for patients . Adequate therapeutic strategies demand thoughtful planning and careful weighting of all treatment options . Multiple brain metastases should be treated in palliative therapy with whole-brain irradiation . In patients with a favourable prognosis and solitary or few brain metastases , surgical excision and radiosurgery are comparable adequate treatment options . Radiosurgery is an non-invasive procedure that can also be performed in non-operable brain areas . The value of additional whole-brain irradiation is under discussion . It has no influence on survival , but the frequence of new brain metastases may be reduced ." ], "offsets": [ [ 0, 684 ] ] } ]

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"id": "DerGynaekologe.90320683.eng.abstr-s6-r3-t1.1-t2.3", "type": "location_of", "arg1_id": "DerGynaekologe.90320683.eng.abstr-s7-t1", "arg2_id": "DerGynaekologe.90320683.eng.abstr-s7-t2", "normalized": [] }, { "id": "DerGynaekologe.90320683.eng.abstr-s6-r4-t1.1-t2.3", "type": "evaluation_of", "arg1_id": "DerGynaekologe.90320683.eng.abstr-s7-t1", "arg2_id": "DerGynaekologe.90320683.eng.abstr-s7-t2", "normalized": [] }, { "id": "DerGynaekologe.90320683.eng.abstr-s6-r5-t3.2-t2.1", "type": "result_of", "arg1_id": "DerGynaekologe.90320683.eng.abstr-s6-t3", "arg2_id": "DerGynaekologe.90320683.eng.abstr-s7-t2", "normalized": [] }, { "id": "DerGynaekologe.90320683.eng.abstr-s6-r6-t1.1-t2.1", "type": "location_of", "arg1_id": "DerGynaekologe.90320683.eng.abstr-s7-t1", "arg2_id": "DerGynaekologe.90320683.eng.abstr-s7-t2", "normalized": [] }, { "id": "DerGynaekologe.90320683.eng.abstr-s6-r8-t2.3-t1.1", "type": "associated_with", "arg1_id": "DerGynaekologe.90320683.eng.abstr-s7-t2", "arg2_id": "DerGynaekologe.90320683.eng.abstr-s7-t1", "normalized": [] } ]

DerGynaekologe.90320705.eng.abstr

[ { "id": "DerGynaekologe.90320705.eng.abstr-passage-0", "type": "abstract", "text": [ "The title of this paper poses a question to which the short answer must be \" yes \" . What oncologist would not wish to be in the enviable position of an infectious diseases physician , who can treat a patient with a serious infection knowing that the organism is sensitive to the antibiotic prescribed ? Unfortunately , cancer cells are not as easy to grow as most bacteria and previous attempts to produce a feasible chemosensitivity assay for clinical use have been largely unsuccessful . Yet the rationale for such assays is sound : not all tumors of one histological type respond in the same way to the same agent . We know that this heterogeneity reflects the molecular phenotype . Over the last 8 years , a new tumor chemosensitivity assay ( ATP-TCA ) based on highly sensitive luminescence technology has been developed to the point where it is now entering phase III trials in ovarian cancer . Results in breast cancer are similarly encouraging , although as yet few patients have been treated prospectively according to the results of the assay . The assay has 97 % evaluability for surgical biopsies with 76 % concordance between clinical response and chemosensitivity . Results from neoadjuvant studies in which needle biopsies and tumor from the mastectomy specimen obtained after three cycles in six cases were tested show the rapid development of resistance in four cases to combination chemotherapy . However , nine courses of chemotherapy given on the basis of the ATP-TCA resulted in partial or complete responses in all nine patients . Phase III clinical trials of ATP-TCA directed therapy against empirical therapy are in progress ." ], "offsets": [ [ 0, 1651 ] ] } ]

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[]

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DerGynaekologe.90320710.eng.abstr

[ { "id": "DerGynaekologe.90320710.eng.abstr-passage-0", "type": "abstract", "text": [ "For patients with carcinoma of the breast the detection of distant metastases means that definitive recovery is no longer possible , since any further treatment can only be palliative in nature . Consequently , the holistic approach of palliative medicine centres on the patients ' quality of life , which is determined not only by their physical condition but also by their level of psychosocial wellbeing . In view of the pain experienced by 75 % of patients with metastatic mammary carcinoma and the effect of pain on their general wellbeing , adequate pain therapy , which can almost always be given by the oral route , so that outpatient treatment is possible , is the first priority . In addition , therapeutic control of other symptoms associated with the tumor or with the treatment is of fundamental importance . Care of these patients makes particular personal demands on the doctors , care staff , etc. , to enable them to provide psychological and human support for those incurable patients in the final stage of their life ." ], "offsets": [ [ 0, 1037 ] ] } ]

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[]

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"arg1_id": "DerGynaekologe.90320710.eng.abstr-s5-t8", "arg2_id": "DerGynaekologe.90320710.eng.abstr-s5-t4", "normalized": [] }, { "id": "DerGynaekologe.90320710.eng.abstr-s5-r20-t4.1-t1.1", "type": "exhibits", "arg1_id": "DerGynaekologe.90320710.eng.abstr-s5-t4", "arg2_id": "DerGynaekologe.90320710.eng.abstr-s5-t1", "normalized": [] }, { "id": "DerGynaekologe.90320710.eng.abstr-s5-r21-t5.1-t1.1", "type": "exhibits", "arg1_id": "DerGynaekologe.90320710.eng.abstr-s5-t5", "arg2_id": "DerGynaekologe.90320710.eng.abstr-s5-t1", "normalized": [] } ]

DerGynaekologe.90320753.eng.abstr

[ { "id": "DerGynaekologe.90320753.eng.abstr-passage-0", "type": "abstract", "text": [ "Pregnancy-induced hypertension and preeclampsia account for nearly 25 % of perinatal morbidity and mortality and are a leading cause of maternal death in developed countries . Consequently , early detection of women with a higher risk is helpful for intensified prenatal care . Since therapeutic options exist in some cases , screening for risk factors is required . Risk factors include parity , medical history , and family history . Laboratory tests of haemostasis and the detection of autoimmune disease complete adequate screening . More than 100 methods have been tested for the prediction of preeclampsia in the second trimester . Results obtained by Doppler ultrasound appear to be more reliable than most clinical parameters . However , no test presently available can really serve as a useful early marker of developing preeclampsia . More specific methods detecting endothelial dysfunction and platelet activation are being developed and might provide improved prediction ." ], "offsets": [ [ 0, 984 ] ] } ]

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[]

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DerGynaekologe.90320768.eng.abstr

[ { "id": "DerGynaekologe.90320768.eng.abstr-passage-0", "type": "abstract", "text": [ "Endothelially derived nitric oxide ( NO ) regulates vasodilatation via relaxation of the smooth muscle cells and inhibits platelet aggregation in addition to a number of other biological processes . Animal experiments have provided evidence for increased NO production in the normal pregnancy . This contributes to the decrease in peripheral vascular resistance and to the increased glomerular filtration rate . Inhibition of NO synthesis is associated with a preeclampsia-like syndrome in various animal species . In vivo and in vitro data in the human pregnancy have indicated that NO deficiency contributes to the vasoconstriction seen in preeclampsia . However , due to the short half-life time of NO , pharmacological application is only possible by NO-donating drugs such as glycerol trinitrate ( GTN , \" nitroglycerine \" ) , isosorbide dinitrate ( ISDN ) , isosorbide mononitrate ( ISMN ) or S-nitrosoglutathion ( GSNO ) . There is limited experience with the use of NO donors in human pregnancy ; yet no teratogenic or embryotoxic effects are reported . According to current knowledge , transdermal application of GTN in pregnancy is safe with only minor effects on maternal blood pressure and without compromising the uteroplacental perfusion in patients with preeclampsia . Up to now only one prospective randomized trial has been conducted on the prophylaxis of preeclampsia by NO donors in women at high risk for development of the disease . However , the sample size of this study was too small to allow final conclusions . There are no randomized trials on the therapy of preeclampsia by NO donors reported in the literature . Therefore , it is that the use of NO donors be evaluated in the prophylaxis and therapy of preeclampsia only recommended in the context of clinical trials ." ], "offsets": [ [ 0, 1797 ] ] } ]

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[]

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DerGynaekologe.90320776.eng.abstr

[ { "id": "DerGynaekologe.90320776.eng.abstr-passage-0", "type": "abstract", "text": [ "There is little to suggest that the course of preeclamsia can be substantially affected by drug treatment . The vast majority of randomized studies do not indicate beneficial effects of antihypertensive treatment on proteinuria , fetal heart rate abnormalities , abruptio placentae and the incidence of preterm birth . There is also no definite effect on the development of superimposed preeclampsia , HELLP syndrome , renal failure or eclampsia . Moreover , blood pressure lowering agents fail to improve uteroplacental perfusion but may have adverse effects on fetal growth . Antihypertensive treatment is only indicated in severe hypertension ( > 170/110 mm Hg ) to reduce the risk of cerebral hemorrhage . Dihydralazine injections may result in reduced placental blood flow and fetal distress . Oral nifedipine offers some advantages in view of more potent vasodilator actions on uterine and fetoplacental vessels and a lower incidence of fetal distress . Increasing evidence suggests that the mechanism of eclamptic seizure is cerebral vasoconstriction with resultant ischemia . Cerebral vessels are particularly sensitive to magnesium , which works by reversing cerebral vasoconstriction with resultant improvement in blood flow . Controlled trials have shown magnesium to be superior to both placebo and phenytoin for the prevention of eclampsia . Furthermore , magnesium has been found to be more effective than diazepam and phenytoin in preventing recurrence of seizures in women with eclampsia . Also the neonatal outcome favors magnesium , which is now generally accepted as the drug of choice for the prevention and treatment of eclampsia ." ], "offsets": [ [ 0, 1652 ] ] } ]

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"type": "associated_with", "arg1_id": "DerGynaekologe.90320776.eng.abstr-s12-t4", "arg2_id": "DerGynaekologe.90320776.eng.abstr-s12-t3", "normalized": [] }, { "id": "DerGynaekologe.90320776.eng.abstr-s12-r5-t4.1-t1.1", "type": "produces", "arg1_id": "DerGynaekologe.90320776.eng.abstr-s12-t4", "arg2_id": "DerGynaekologe.90320776.eng.abstr-s12-t1", "normalized": [] }, { "id": "DerGynaekologe.90320776.eng.abstr-s12-r6-t2.1-t1.1", "type": "interacts_with", "arg1_id": "DerGynaekologe.90320776.eng.abstr-s12-t2", "arg2_id": "DerGynaekologe.90320776.eng.abstr-s12-t1", "normalized": [] }, { "id": "DerGynaekologe.90320776.eng.abstr-s12-r7-t1.1-t2.1", "type": "interacts_with", "arg1_id": "DerGynaekologe.90320776.eng.abstr-s12-t1", "arg2_id": "DerGynaekologe.90320776.eng.abstr-s12-t2", "normalized": [] }, { "id": "DerGynaekologe.90320776.eng.abstr-s12-r8-t1.1-t4.1", "type": "affects", "arg1_id": "DerGynaekologe.90320776.eng.abstr-s12-t1", "arg2_id": "DerGynaekologe.90320776.eng.abstr-s12-t4", "normalized": [] } ]

DerGynaekologe.90320783.eng.abstr

[ { "id": "DerGynaekologe.90320783.eng.abstr-passage-0", "type": "abstract", "text": [ "HELLP syndrome is characterized by a high incidence of fetal and maternal morbidity and mortality . It is known that the clinical and biochemical course in patients with HELLP syndrome improves spontaneously after prompt termination of pregnancy . The disadvantages of this regimen is the high rate of prematurity before the 32nd gestational week . In contrast to the routine recommendations , 12 studies including 330 patients have demonstrated that pregnancy prolongation in patients with HELLP syndrome may offer certain advantages . There is evidence that glucocorticosteroids may affect the course of HELLP syndrome before and even after the pregnancies are terminated . In 8 out of the 12 studies steroids were at least administered in some of the cases . Nevertheless , only a single randomized and controlled study was performed that demonstrated an effect in patients treated with steroids as compared to non-steroid-treated HELLP patients . Several additional studies have shown that puerperal recovery in patients with antepartum HELLP syndrome is accelerated if steroids are given . In contrast to evidence of the benefit of steroids , another study has demonstrated pregnancy prolongation in HELLP patients without the administration of glucocorticoids . In the future additional extensive studies should define inclusion criteria for pregnancy prolongation in patients with HELLP syndrome . Furthermore , the effect of different existing therapeutic regimes - particularly the effect of steroids - on the course of pregnancies complicated by HELLP syndrome should be investigated ." ], "offsets": [ [ 0, 1595 ] ] } ]

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[]

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"arg2_id": "DerGynaekologe.90320783.eng.abstr-s11-t1", "normalized": [] }, { "id": "DerGynaekologe.90320783.eng.abstr-s11-r14-t1.1-t5.1", "type": "associated_with", "arg1_id": "DerGynaekologe.90320783.eng.abstr-s11-t1", "arg2_id": "DerGynaekologe.90320783.eng.abstr-s11-t5", "normalized": [] }, { "id": "DerGynaekologe.90320783.eng.abstr-s11-r15-t1.1-t4.1", "type": "associated_with", "arg1_id": "DerGynaekologe.90320783.eng.abstr-s11-t1", "arg2_id": "DerGynaekologe.90320783.eng.abstr-s11-t4", "normalized": [] }, { "id": "DerGynaekologe.90320783.eng.abstr-s11-r16-t6.1-t3.1", "type": "result_of", "arg1_id": "DerGynaekologe.90320783.eng.abstr-s11-t6", "arg2_id": "DerGynaekologe.90320783.eng.abstr-s11-t3", "normalized": [] }, { "id": "DerGynaekologe.90320783.eng.abstr-s11-r17-t3.1-t5.1", "type": "result_of", "arg1_id": "DerGynaekologe.90320783.eng.abstr-s11-t3", "arg2_id": "DerGynaekologe.90320783.eng.abstr-s11-t5", "normalized": [] } ]

DerGynaekologe.90320791.eng.abstr

[ { "id": "DerGynaekologe.90320791.eng.abstr-passage-0", "type": "abstract", "text": [ "The laboratory findings of hemolysis , elevated liver enzymes and low platelets are signs of an acute pregnancy complication often associated with abdominal pain and intrauterine growth retardation . A high coincidence with symptoms of preeclampsia is observed . The high rate of complications and the restitution of laboratory findings to normal values following cessation of pregnancy have led to the general recommendation of immediate delivery for about a decade . However , the fact that HELLP syndrome can also occur for up to 1 week post-partum and the results of studies on prolongation of pregnancy call this former concept of management into question , in particular , since there is a high rate of hemostasiological complications after cesarean section in acute HELLP syndrome . Because of the correlation of complications of HELLP syndrome with those of severe preeclampsia , the indication for delivery should be based on the signs of preeclampsia and additional clinical features . The results of studies on prolongation of pregnancies in HELLP syndrome and severe preeclampsia support this concept ." ], "offsets": [ [ 0, 1114 ] ] } ]

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"db_id": "C0683368" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "preeclampsia" ], "offsets": [ [ 236, 248 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032914" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "complications" ], "offsets": [ [ 280, 293 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009566" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "laboratory" ], "offsets": [ [ 317, 327 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022877" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "findings" ], "offsets": [ [ 328, 336 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243095" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "values" ], "offsets": [ [ 347, 353 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042295" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "pregnancy" ], "offsets": [ [ 377, 386 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "recommendation" ], "offsets": [ [ 411, 425 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034866" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s3-t7", "type": "umlsterm", "text": [ "delivery" ], "offsets": [ [ 439, 447 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011209" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s3-t8", "type": "umlsterm", "text": [ "normal values" ], "offsets": [ [ 340, 353 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086715" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "syndrome" ], "offsets": [ [ 499, 507 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "DerGynaekologe.90320791.eng.abstr-s4-t2", 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[]

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DerGynaekologe.90320823.eng.abstr

[ { "id": "DerGynaekologe.90320823.eng.abstr-passage-0", "type": "abstract", "text": [ "Amniotic fluid is a major factor of the intrauterine environment , and deviation from the normal volume is associated with an increased perinatal morbidity and mortality . Polyhydramnios occurs in 0.2 to 1.6 % of pregnancies . It may be due to a number of congenital anomalies , an abnormal karyotype , maternal diabetes , Rh-disease or intrauterine infections potentially requiring non-invasive or invasive measures . However , the most common indication for prenatal intervention due to polyhydramnios is the Twin-Twin-Transfusion Syndrom ( TTTS ) . Treatment of polyhydramnios may focus on correction of the causative lesion , or symptomatic relief through drainage of amniotic fluid . Maternal administration of cyclooxygenase inhibitors represents a further , non-invasive therapeutic option . Indomethacin , Sulindac , or Nimesulide reduce the fetal urine output thus decreasing amniotic fluid volume over time without the risks associated with invasive procedures . However , potentially serious ductal constriction as well as a delay in the onset of amniotic fluid reduction have limited its application . Percutaneous amniotic fluid drainage may provide immediate reduction of intrauterine pressure , but is associated with a complication rate of 1 to 1.5 % . The hemodynamic characteristics of monochorionic pregnancies complicated by TTTS have led to the development of endoscopic laser coagulation of placental vascular anastomoses as a definitive treatment . Treatment is only required in a small minoritiy of pregnancies with polyhydramnios . Mild cases can be managed expectatively . Intrauterine pressure increases with an excessive increase in amniotic fluid volume ( AFI > 400 mm or MVP > 150 mm ) leads to the elevation of intrauterine pressure . Complications such as preterm premature rupture of membranes and preterm labor may lead to premature delivery . The main goal of prenatal treatment of polyhydramnios is thus the improvement of fetal outcome through prolongation of gestation and/or the alleviation of maternal symptoms ." ], "offsets": [ [ 0, 2052 ] ] } ]

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[]

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"normalized": [] }, { "id": "DerGynaekologe.90320823.eng.abstr-s14-r22-t6.1-t5.1", "type": "associated_with", "arg1_id": "DerGynaekologe.90320823.eng.abstr-s14-t6", "arg2_id": "DerGynaekologe.90320823.eng.abstr-s14-t5", "normalized": [] }, { "id": "DerGynaekologe.90320823.eng.abstr-s14-r23-t7.1-t1.1", "type": "result_of", "arg1_id": "DerGynaekologe.90320823.eng.abstr-s14-t7", "arg2_id": "DerGynaekologe.90320823.eng.abstr-s15-t1", "normalized": [] }, { "id": "DerGynaekologe.90320823.eng.abstr-s14-r24-t7.1-t6.1", "type": "degree_of", "arg1_id": "DerGynaekologe.90320823.eng.abstr-s14-t7", "arg2_id": "DerGynaekologe.90320823.eng.abstr-s14-t6", "normalized": [] }, { "id": "DerGynaekologe.90320823.eng.abstr-s14-r25-t1.1-t5.1", "type": "associated_with", "arg1_id": "DerGynaekologe.90320823.eng.abstr-s15-t1", "arg2_id": "DerGynaekologe.90320823.eng.abstr-s14-t5", "normalized": [] }, { "id": "DerGynaekologe.90320823.eng.abstr-s14-r26-t7.1-t4.1", "type": "result_of", "arg1_id": "DerGynaekologe.90320823.eng.abstr-s14-t7", "arg2_id": "DerGynaekologe.90320823.eng.abstr-s15-t4", "normalized": [] }, { "id": "DerGynaekologe.90320823.eng.abstr-s14-r27-t4.1-t6.1", "type": "result_of", "arg1_id": "DerGynaekologe.90320823.eng.abstr-s15-t4", "arg2_id": "DerGynaekologe.90320823.eng.abstr-s14-t6", "normalized": [] }, { "id": "DerGynaekologe.90320823.eng.abstr-s14-r28-t7.1-t5.1", "type": "associated_with", "arg1_id": "DerGynaekologe.90320823.eng.abstr-s14-t7", "arg2_id": "DerGynaekologe.90320823.eng.abstr-s14-t5", "normalized": [] }, { "id": "DerGynaekologe.90320823.eng.abstr-s15-r1-t2.1-t4.1", "type": "associated_with", "arg1_id": "DerGynaekologe.90320823.eng.abstr-s15-t2", "arg2_id": "DerGynaekologe.90320823.eng.abstr-s15-t4", "normalized": [] }, { "id": "DerGynaekologe.90320823.eng.abstr-s15-r2-t2.1-t4.1", "type": "treats", "arg1_id": "DerGynaekologe.90320823.eng.abstr-s15-t2", "arg2_id": "DerGynaekologe.90320823.eng.abstr-s15-t4", "normalized": [] }, { "id": "DerGynaekologe.90320823.eng.abstr-s15-r3-t4.1-t2.1", "type": "associated_with", "arg1_id": "DerGynaekologe.90320823.eng.abstr-s15-t4", "arg2_id": "DerGynaekologe.90320823.eng.abstr-s15-t2", "normalized": [] } ]

DerGynaekologe.90320832.eng.abstr

[ { "id": "DerGynaekologe.90320832.eng.abstr-passage-0", "type": "abstract", "text": [ "The incidence of severe reduced amniotic fluid volume in the 2nd trimester is rare , but causes a dramatic rise in morbidity and mortality of the fetus . Since Gembruch and Hansmann [ 12 ] reported about their experiences with the diagnostic and therapeutic approach of amnioinfusion in 1988 there followed sporadic reports about amnioinfusion by other investigators . In the following the experiences with diagnostic and therapeutic amnioinfusion in the 2nd trimester and the technique will be disscussed ." ], "offsets": [ [ 0, 507 ] ] } ]

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[]

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DerGynaekologe.90320855.eng.abstr

[ { "id": "DerGynaekologe.90320855.eng.abstr-passage-0", "type": "abstract", "text": [ "In this review the indications , techniques , results and perspectives of operative fetoscopy are described and discussed . Prenatal invasive therapy is indicated if postnatal therapy comes too late and fetal disease may lead to irreversible damage or death if it is left untreated . Potential candidates for intrauterine surgery are pregnancies with the following problems : diaphragmatic hernia , infravesical obstruction , sacrococcygeal teratoma , chorioangioma , neural tube defects , twin-twin transfusion syndrome and acardiac twin . The aim is to improve the intrauterine situation by minimally invasive surgery and to prevent irreversible damage . After delivery permanent repair is possible in cases with fetal malformations . Diaphragmatic hernia is the best example for the development from maximally invasive open fetal surgery to minimally invasive endoscopic surgery . There is still a lot of experimental work to be done , for example for the correction of diaphragmatic hernia and neural tube defects . However , in other areas such as severe second trimester twin-twin transfusion syndrome , endoscopic surgery is a well established technique in certain centres for fetal medicine . Endoscopic laser coagulation of the vascular placental anastomoses is a causal therapy and shows better results than serial amniodrainages . After 160 laser coagulations performed in our institution , the survival rates are as follows : overall 68 % of fetuses , with two survivors in 54 % and at least one survivor in 83 % of pregnancies ." ], "offsets": [ [ 0, 1541 ] ] } ]

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"db_id": "C0039798" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 209, 216 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "death" ], "offsets": [ [ 252, 257 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011065" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "fetal disease" ], "offsets": [ [ 203, 216 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015929" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "surgery" ], "offsets": [ [ 322, 329 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038894" }, { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "pregnancies" ], "offsets": [ [ 334, 345 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "hernia" ], "offsets": [ [ 390, 396 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019270" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "teratoma" ], "offsets": [ [ 441, 449 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039538" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "chorioangioma" ], "offsets": [ [ 452, 465 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018916" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "defects" ], "offsets": [ [ 480, 487 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243067" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s3-t7", "type": "umlsterm", "text": [ "twin-twin" ], "offsets": [ [ 490, 499 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0041426" }, { "db_name": "UMLS", "db_id": "C0041427" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s3-t8", "type": "umlsterm", "text": [ "twin-twin" ], "offsets": [ [ 490, 499 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0041426" }, { "db_name": "UMLS", "db_id": "C0041427" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s3-t9", "type": "umlsterm", "text": [ "syndrome" ], "offsets": [ [ 512, 520 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s3-t10", "type": "umlsterm", "text": [ "twin" ], "offsets": [ [ 534, 538 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0041426" }, { "db_name": "UMLS", "db_id": "C0041427" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s3-t11", "type": "umlsterm", "text": [ "diaphragmatic hernia" ], "offsets": [ [ 376, 396 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019284" } ] }, { "id": "DerGynaekologe.90320855.eng.abstr-s3-t12", "type": "umlsterm", "text": [ "neural tube defects" ], "offsets": [ [ 468, 487 ] ], 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[]

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DerGynaekologe.90320866.eng.abstr

[ { "id": "DerGynaekologe.90320866.eng.abstr-passage-0", "type": "abstract", "text": [ "Although most prenatally diagnosed anatomic malformations are best managed after birth , we can presently offer prenatal therapy to an increasing number of fetuses with simple anatomical defects that have predictably devastating developmental consequences . A condition amenable to prenatal intervention must fulfill a number of conditions . It must be severe enough to warrant the risks associated with in utero treatment and must be reliably detectable before birth . Furthermore , the pathophysiology must be reversible by fetal intervention , significantly improving the prognosis over postnatal treatment . Current indication for prenatal intervention include decompression for obstructive uropathy , temporary tracheal occlusion for congenital diaphragmatic hernia , and tumor debulking for congenital cystic adenomatoid malformation of the lung and sacrococcygeal teratoma . Prenatal repair of myelomeningocele is currently being developed but remains controversial since this is not a lethal malformation . Maternal safety remains paramount in considering fetal intervention . The main associated risks are pre-term labor and preterm premature rupture of membranes . To reduce maternal morbidity and the risk of prematurity , minimally invasive fetoscopic techniques were developed and are increasingly employed . These developments will in all probability reduce the importance of open fetal surgery in the future ." ], "offsets": [ [ 0, 1424 ] ] } ]

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[]

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DerGynaekologe.90320927.eng.abstr

[ { "id": "DerGynaekologe.90320927.eng.abstr-passage-0", "type": "abstract", "text": [ "The doctor in charge , who is generally the medical director , is liable if patients suffer harm through organizational faults within his or her department . Even the suspicion that an error has arisen as the result of defective organization is enough for the person responsible - that is to say the medical director - to be liable . For this reason , the doctor in charge must be in a position to recognize structural defects in organization and to correct these by means of staff training . Every training measure must guarantee specialist standards ; this means that the work of doctors with no specialist training and those still in training and working under supervision is guaranteed to be of the same standard and performed with the same degree of meticulous care as that of a qualified specialist . A legally valid consent from the patient and documentation of the patient information must be accessible at all times . Operations carried out by doctors in training must be supervised by a qualified specialist ; otherwise the doctor in charge is guilty of a defect in organization . Because of staff shortages it often happens that inexperienced beginners - often doctors doing their practical training - are on call very early on . In the high-risk specialty of obstetrics it is particularly important that doctors still undergoing practical training can call on an experienced colleague for help at all times . The changeover from day duty to emergency duty must be organized by the doctor in charge in such a way that the medical staff are rested and that adequate free time is guaranteed . There must be no friction when cooperation with other disciplines concerned is needed . Each sector must know its own area of responsibility . The doctor in charge is resonsible for seeing that his or her staff members are familiar with the use of the medical equipment . Uniform guidelines will make it possible for the medical director to train his/her staff and prevent systematic organizational defects ." ], "offsets": [ [ 0, 2010 ] ] } ]

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[]

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"arg2_id": "DerGynaekologe.90320927.eng.abstr-s8-t3", "normalized": [] }, { "id": "DerGynaekologe.90320927.eng.abstr-s8-r3-t2.1-t3.1", "type": "performs", "arg1_id": "DerGynaekologe.90320927.eng.abstr-s13-t2", "arg2_id": "DerGynaekologe.90320927.eng.abstr-s13-t3", "normalized": [] }, { "id": "DerGynaekologe.90320927.eng.abstr-s8-r4-t3.1-t1.1", "type": "method_of", "arg1_id": "DerGynaekologe.90320927.eng.abstr-s13-t3", "arg2_id": "DerGynaekologe.90320927.eng.abstr-s13-t1", "normalized": [] }, { "id": "DerGynaekologe.90320927.eng.abstr-s8-r5-t2.1-t1.1", "type": "issue_in", "arg1_id": "DerGynaekologe.90320927.eng.abstr-s13-t2", "arg2_id": "DerGynaekologe.90320927.eng.abstr-s13-t1", "normalized": [] }, { "id": "DerGynaekologe.90320927.eng.abstr-s12-r1-t1.1-t4.2", "type": "uses", "arg1_id": "DerGynaekologe.90320927.eng.abstr-s13-t1", "arg2_id": "DerGynaekologe.90320927.eng.abstr-s12-t4", "normalized": [] } ]

DerGynaekologe.90320933.eng.abstr

[ { "id": "DerGynaekologe.90320933.eng.abstr-passage-0", "type": "abstract", "text": [ "A differentiation is made between patient information on findings and diagnosis , patient information on avoidance of known dangers , and patient information on the risks involved in a particular intervention that has been selected . If no information is given on the risks inherent in a patient's condition and how she must proceed in order to ensure that they do not come about , this is considered to be a treatment error , and in these circumstances the intervention is then legally seen as bodily harm . Information on the risks involved in an intervention must be given in good time , which generally means on the day before the operation . An exception is made to this rule for day surgery . The patient must be informed about treatment alternatives when the method selected is not the method of choice or when there is an alternative offering equivalent chances but risks of a different kind . Such information is given to the adult patient who is capable of legal transactions . In the case of minors or of patients who are not capable of legal transactions their legal representative is responsible for receiving the information [ and making decisions ] . In the case of unconscious patients everything depends on \" presumable consent to the operation \" . If a patient later cites lacks in the information supplied to her to support a claim for compensation in a situation where it would be unwise to refuse an operation , she must elaborate plausible grounds for being in conflict over the decision even following appropriate information ." ], "offsets": [ [ 0, 1550 ] ] } ]

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[]

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DerGynaekologe.90320939.eng.abstr

[ { "id": "DerGynaekologe.90320939.eng.abstr-passage-0", "type": "abstract", "text": [ "Since the 1970 s careful documentation of treatments performed or not performed has been part of a doctor's duties . This includes patient-related matters such as consent , refusal or actions taken contrary to medical advice . If an intervention is not documented , it is assumed in the event of a claim for damages in the patient's favour that the treatment has not taken place . In gynaecology and obstetrics there are frequent legal actions as the result of defective documentation , especially in the sectors of early cancer diagnosis , pregnancy counselling and prenatal diagnosis , and also in the case of operative interventions . Because of the different persons involved and the various areas of responsibility , documentation of the birth process is particularly difficult . It should therefore be decided at the start who is to note down its course . When endoscopic investigations are carried out it seems advisable to take short video sequences recording the salient points . Patients have a fundamental right to sight of their treatment records . In the event of a patient's death the next of kin are entitled to sight of the records , providing the patient has not left any formal request that they be kept secret ." ], "offsets": [ [ 0, 1230 ] ] } ]

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[]

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DerGynaekologe.90320944.eng.abstr

[ { "id": "DerGynaekologe.90320944.eng.abstr-passage-0", "type": "abstract", "text": [ "An overall view shows that the organization of a department of gynaecology and obstetrics is a highly complex task . Not only formal , legal positions have a role in this ; personal strengths , such as the ability to convince others by professional and personal authority and by exerting the will to manage , are also essential . Management requires the superintendent to define his or her own range of duties in collaboration with a representative or representatives of the authority responsible for the hospital . It has proved worthwhile for the responsible authority and the medical superintendent to lay down guidelines for procedures and instructions to be adopted in standard situations ( indications , informing assistant medical director , paediatrics and neonatology , examination to be carried out on admission , division of labour with midwives , etc. ) in writing , to inform the staff of these together , and to deposit the guidelines at a central point in the department , so that any member of staff can consult them without any substantial hold-up if there are any points of dispute or uncertainties ." ], "offsets": [ [ 0, 1118 ] ] } ]

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[]

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"DerGynaekologe.90320944.eng.abstr-s4-r25-t7.1-t1.3", "type": "issue_in", "arg1_id": "DerGynaekologe.90320944.eng.abstr-s4-t7", "arg2_id": "DerGynaekologe.90320944.eng.abstr-s4-t1", "normalized": [] }, { "id": "DerGynaekologe.90320944.eng.abstr-s4-r27-t8.3-t3.1", "type": "uses", "arg1_id": "DerGynaekologe.90320944.eng.abstr-s4-t8", "arg2_id": "DerGynaekologe.90320944.eng.abstr-s4-t3", "normalized": [] }, { "id": "DerGynaekologe.90320944.eng.abstr-s4-r28-t7.1-t1.3", "type": "uses", "arg1_id": "DerGynaekologe.90320944.eng.abstr-s4-t7", "arg2_id": "DerGynaekologe.90320944.eng.abstr-s4-t1", "normalized": [] } ]

DerGynaekologe.90320953.eng.abstr

[ { "id": "DerGynaekologe.90320953.eng.abstr-passage-0", "type": "abstract", "text": [ "Malpractice still involves the highest risk of being found liable for damages in the obstetrics and gynaecology sector . Awareness of faults that are particularly frequent and involve liability for particularly high damages can help practitioners to avoid them . Following the definition of ' malpractice ' , the role of directives and standards is briefly discussed . Then the forms of malpractice are presented : errors in diagnosis , faulty therapy , culpable failure to provide adequate information on patients transferred to the care of others , and provision of poor advice ; typical faults are explained with reference to clinical examples and/or case reports . Particular attention is paid to grave malpractice with consequent reversal of the burden of proof , which is also illustrated by reference to examples of cases . It is shown that the highest risk of liability for damages after malpractice , with extremely high sums awarded in some cases , applies in the case of obstetrics , primarily as a result of not performing cesarian sections or of performing them too late . Problems of causation are then discussed , particularly in view of the changed legal practice , in cases of cerebral damage suffered by children , of regularly commissioning expert assessments from paediatric neurologists and neonatologists , which can incriminate or exonerate the obstetrician . Attention is drawn to the fact - which is still too tittle known - that even the nonascertainment of urgently required findings can lead to reversal of the burden of proof in the same way as an instance of \" grave malpractice \" ." ], "offsets": [ [ 0, 1612 ] ] } ]

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[]

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DerHautarzt.00510003.eng.abstr

[ { "id": "DerHautarzt.00510003.eng.abstr-passage-0", "type": "abstract", "text": [ "In Germany , if the dermatologist has definite proof that a patient's skin disorder is severe or chronic , work-related and requiring a change in occupation , then he or she must issue a Berufskrankheitenanzeige ( loosely translated as occupational disease notification ) . The patient's consent is not required for this mandatory form , which has to be submitted even if the patient is opposed . On the other hand , if there is only a possible connection between the occupation and the skin disorder , or if the skin disease is neither severe nor chronic nor threatening pursuit of the occupation , then the dermatologist needs only write a Hautarztbericht ( dermatologist's report ) . The patient's permission is required for this less formal document ." ], "offsets": [ [ 0, 755 ] ] } ]

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[]

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DerHautarzt.00510014.eng.abstr

[ { "id": "DerHautarzt.00510014.eng.abstr-passage-0", "type": "abstract", "text": [ "Background and objective : A complicated course of erysipelas is not uncommon . Bullous , haemorrhagic , necrotic and purulent lesions may be encountered . Today no reliable data exist as to which constitutional factors renders a patient at risk for developing complicated erysipelas though several risk factors , particularly diabetes mellitus , are often suggested . Based on the analysis of patients with erysipelas at the Department of Dermatology in Graz , factors determining the risk for complicated erysipelas should be identified . Patients/Methods : In a retrospective case-control study clinical data sheets of 766 in- patients treated at the department were evaluated with respect to the course of the erysipelas and with respect to potential risk factors . Results : General risk factors for local complications were location at the lower extremities , pre-existing hepatic or renal disease , hyperuricaemia , and diabetes mellitus . Hepatic and renal disease and - to a lesser extent - diabetes particularly predisposed for bullous and haemorrhagic lesions , while vascular occlusive disease enhanced the risk for ne- crotic lesions . Conclusions : Location and hepatic and renal disease are the most important risk factors , while diabetes is probably of less significance than previously suggested ." ], "offsets": [ [ 0, 1315 ] ] } ]

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"risk" ], "offsets": [ [ 299, 303 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "diabetes" ], "offsets": [ [ 327, 335 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011847" }, { "db_name": "UMLS", "db_id": "C0011849" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "risk factors" ], "offsets": [ [ 299, 311 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035648" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s3-t7", "type": "umlsterm", "text": [ "diabetes mellitus" ], "offsets": [ [ 327, 344 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011849" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "analysis" ], "offsets": [ [ 382, 390 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002778" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 394, 402 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "erysipelas" ], "offsets": [ [ 408, 418 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014733" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "Dermatology" ], "offsets": [ [ 440, 451 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011627" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "risk" ], "offsets": [ [ 486, 490 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s4-t6", "type": "umlsterm", "text": [ "erysipelas" ], "offsets": [ [ 507, 517 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014733" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "retrospective" ], "offsets": [ [ 565, 578 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035363" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 630, 638 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "erysipelas" ], "offsets": [ [ 714, 724 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014733" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "risk" ], "offsets": [ [ 755, 759 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s5-t5", "type": "umlsterm", "text": [ "case-control study" ], "offsets": [ [ 579, 597 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007328" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s5-t6", "type": "umlsterm", "text": [ "risk factors" ], "offsets": [ [ 755, 767 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035648" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "risk" ], "offsets": [ [ 788, 792 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "complications" ], "offsets": [ [ 811, 824 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009566" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "extremities" ], "offsets": [ [ 852, 863 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015385" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 896, 903 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s6-t5", "type": "umlsterm", "text": [ "diabetes" ], "offsets": [ [ 927, 935 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011847" }, { "db_name": "UMLS", "db_id": "C0011849" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s6-t6", "type": "umlsterm", "text": [ "risk factors" ], "offsets": [ [ 788, 800 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035648" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s6-t7", "type": "umlsterm", "text": [ "lower extremities" ], "offsets": [ [ 846, 863 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023216" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s6-t8", "type": "umlsterm", "text": [ "renal disease" ], "offsets": [ [ 890, 903 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022658" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 965, 972 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s7-t2", "type": "umlsterm", "text": [ "diabetes" ], "offsets": [ [ 1000, 1008 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011847" }, { "db_name": "UMLS", "db_id": "C0011849" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s7-t3", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 1098, 1105 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s7-t4", "type": "umlsterm", "text": [ "risk" ], "offsets": [ [ 1119, 1123 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s7-t5", "type": "umlsterm", "text": [ "renal disease" ], "offsets": [ [ 959, 972 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022658" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s8-t1", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 1194, 1201 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s8-t2", "type": "umlsterm", "text": [ "risk" ], "offsets": [ [ 1225, 1229 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s8-t3", "type": "umlsterm", "text": [ "diabetes" ], "offsets": [ [ 1246, 1254 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011847" }, { "db_name": "UMLS", "db_id": "C0011849" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s8-t4", "type": "umlsterm", "text": [ "renal disease" ], "offsets": [ [ 1188, 1201 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022658" } ] }, { "id": "DerHautarzt.00510014.eng.abstr-s8-t5", "type": "umlsterm", "text": [ "risk factors" ], "offsets": [ [ 1225, 1237 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035648" } ] } ]

[]

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[] }, { "id": "DerHautarzt.00510014.eng.abstr-s6-r14-t7.1-t8.1", "type": "location_of", "arg1_id": "DerHautarzt.00510014.eng.abstr-s6-t7", "arg2_id": "DerHautarzt.00510014.eng.abstr-s6-t8", "normalized": [] } ]

DerHautarzt.00510025.eng.abstr

[ { "id": "DerHautarzt.00510025.eng.abstr-passage-0", "type": "abstract", "text": [ "Background and Objective : Pemphigoid gestationis ( PG ) is a rare pregnancy-associated autoimmune bullous disease characterized by autoantibodies to the 180 kD bullous pemphigoid antigen ( BP180). The clinical spectrum of PG is polymorphic and for diagnostic purposes , a skin biopsy is usually taken demonstrating the deposition of autoantibodies ." ], "offsets": [ [ 0, 350 ] ] } ]

[ { "id": "DerHautarzt.00510025.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Objective" ], "offsets": [ [ 15, 24 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018017" } ] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "Pemphigoid" ], "offsets": [ [ 27, 37 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030805" } ] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "pregnancy-associated" ], "offsets": [ [ 67, 87 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 107, 114 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "autoantibodies" ], "offsets": [ [ 132, 146 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004358" } ] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "pemphigoid" ], "offsets": [ [ 169, 179 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030805" } ] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "antigen" ], "offsets": [ [ 180, 187 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003320" } ] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "diagnostic" ], "offsets": [ [ 249, 259 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-t9", "type": "umlsterm", "text": [ "skin" ], "offsets": [ [ 273, 277 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-t10", "type": "umlsterm", "text": [ "biopsy" ], "offsets": [ [ 278, 284 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220797" }, { "db_name": "UMLS", "db_id": "C0005558" } ] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-t11", "type": "umlsterm", "text": [ "autoantibodies" ], "offsets": [ [ 334, 348 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004358" } ] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-t12", "type": "umlsterm", "text": [ "bullous pemphigoid" ], "offsets": [ [ 161, 179 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030805" } ] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-t13", "type": "umlsterm", "text": [ "bullous pemphigoid antigen" ], "offsets": [ [ 161, 187 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0054218" } ] } ]

[]

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"type": "produces", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t3", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t5", "normalized": [] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-r21-t5.1-t3.1", "type": "affects", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t5", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t3", "normalized": [] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-r22-t11.1-t6.1", "type": "indicates", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t11", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t6", "normalized": [] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-r23-t8.1-t10.1", "type": "location_of", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t8", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t10", "normalized": [] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-r24-t3.1-t6.1", "type": "result_of", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t3", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t6", "normalized": [] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-r25-t10.1-t13.1", "type": "analyzes", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t10", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t13", "normalized": [] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-r26-t13.1-t5.1", "type": "interacts_with", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t13", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t5", "normalized": [] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-r27-t13.1-t2.1", "type": "affects", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t13", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t2", "normalized": [] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-r28-t7.1-t3.1", "type": "affects", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t7", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t3", "normalized": [] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-r29-t3.1-t8.1", "type": "affects", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t3", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t8", "normalized": [] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-r30-t7.1-t13.1", "type": "interacts_with", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t7", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t13", "normalized": [] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-r31-t10.1-t7.1", "type": "analyzes", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t10", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t7", "normalized": [] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-r32-t13.1-t12.1", "type": "affects", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t13", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t12", "normalized": [] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-r33-t5.1-t12.1", "type": "indicates", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t5", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t12", "normalized": [] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-r34-t11.1-t8.1", "type": "disrupts", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t11", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t8", "normalized": [] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-r35-t11.1-t13.1", "type": "interacts_with", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t11", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t13", "normalized": [] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-r36-t8.1-t13.1", "type": "produces", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t8", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t13", "normalized": [] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-r37-t11.1-t4.1", "type": "indicates", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t11", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t4", "normalized": [] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-r38-t3.1-t4.1", "type": "result_of", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t3", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t4", "normalized": [] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-r39-t5.1-t6.1", "type": "indicates", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t5", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t6", "normalized": [] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-r40-t10.1-t11.1", "type": "analyzes", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t10", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t11", "normalized": [] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-r41-t10.1-t12.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t10", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t12", "normalized": [] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-r42-t7.1-t12.1", "type": "indicates", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t7", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t12", "normalized": [] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-r43-t10.1-t5.1", "type": "analyzes", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t10", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t5", "normalized": [] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-r44-t13.1-t6.1", "type": "affects", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t13", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t6", "normalized": [] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-r45-t7.1-t6.1", "type": "indicates", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t7", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t6", "normalized": [] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-r46-t1.1-t10.1", "type": "conceptual_part_of", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t1", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t10", "normalized": [] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-r47-t8.1-t6.1", "type": "location_of", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t8", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t6", "normalized": [] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-r48-t8.1-t7.1", "type": "produces", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t8", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t7", "normalized": [] }, { "id": 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"normalized": [] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-r54-t8.1-t3.1", "type": "measurement_of", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t8", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t3", "normalized": [] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-r55-t10.1-t4.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t10", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t4", "normalized": [] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-r56-t11.1-t12.1", "type": "indicates", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t11", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t12", "normalized": [] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-r57-t10.1-t3.1", "type": "measures", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t10", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t3", "normalized": [] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-r58-t3.1-t11.1", "type": "produces", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t3", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t11", "normalized": [] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-r59-t5.1-t8.1", "type": "disrupts", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t5", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t8", "normalized": [] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-r60-t10.1-t2.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t10", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t2", "normalized": [] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-r61-t8.1-t4.1", "type": "location_of", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t8", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t4", "normalized": [] }, { "id": "DerHautarzt.00510025.eng.abstr-s1-r62-t13.1-t11.1", "type": "interacts_with", "arg1_id": "DerHautarzt.00510025.eng.abstr-s1-t13", "arg2_id": "DerHautarzt.00510025.eng.abstr-s1-t11", "normalized": [] } ]

DerHautarzt.00510031.eng.abstr

[ { "id": "DerHautarzt.00510031.eng.abstr-passage-0", "type": "abstract", "text": [ "Hyperkeratosis lenticularis perstans ( Flegel's disease ) is a rare but clinically and histologically highly characteristic genodermatosis . We report on new immunohistochemical and ultrastructural findings suggesting a complex disorder of epidermal differentiation . In this context , a good response to calcipotriol , a synthetic vitamin D3 derivative is of particular interest ." ], "offsets": [ [ 0, 381 ] ] } ]

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[]

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DerHautarzt.00510036.eng.abstr

[ { "id": "DerHautarzt.00510036.eng.abstr-passage-0", "type": "abstract", "text": [ "Calciphylaxis is a rare but potentially life-threatening complication in chronic renal failure . It is characterized by ischemic tissue necrosis primarily of the skin . The typical histopathologic finding is microvascular calcification with endovascular fibrosis . Patients typically present with violaceous , mottled and painful lesions which tend to progress to non-healing ulcers and necrosis . Most frequently the lower extremities are involved in a symmetric fashion but the trunk may also be affected . Sepsis from superinfection of the lesions accounts for the high mortality of this disease which is of importance for dermatologists and nephrologists alike . 61-year-old female patient developed lesions of calciphylaxis on both calves two years after beginning hemodialysis to treat renal failure due to diabetic glomerulosclerosis . We discuss aspects of the pathogenesis of calciphylaxis , as well as diagnosis , treatment and means of preventions , and review the current literature ." ], "offsets": [ [ 0, 996 ] ] } ]

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"umlsterm", "text": [ "tissue" ], "offsets": [ [ 129, 135 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040300" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "necrosis" ], "offsets": [ [ 136, 144 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027540" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "skin" ], "offsets": [ [ 162, 166 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "finding" ], "offsets": [ [ 197, 204 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243095" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "calcification" ], "offsets": [ [ 222, 235 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006660" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "fibrosis" ], "offsets": [ [ 254, 262 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016059" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "Patients" ], "offsets": [ [ 265, 273 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "ulcers" ], "offsets": [ [ 376, 382 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0041582" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "necrosis" ], "offsets": [ [ 387, 395 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027540" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "extremities" ], "offsets": [ [ 424, 435 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015385" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "lower extremities" ], "offsets": [ [ 418, 435 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023216" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "Sepsis" ], "offsets": [ [ 509, 515 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243026" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "superinfection" ], "offsets": [ [ 521, 535 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038826" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "mortality" ], "offsets": [ [ 573, 582 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026566" }, { "db_name": "UMLS", "db_id": "C0026565" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 591, 598 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "female" ], "offsets": [ [ 679, 685 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086287" }, { "db_name": "UMLS", "db_id": "C0015780" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s7-t2", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 686, 693 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s7-t3", "type": "umlsterm", "text": [ "calciphylaxis" ], "offsets": [ [ 715, 728 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006666" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s7-t4", "type": "umlsterm", "text": [ "hemodialysis" ], "offsets": [ [ 770, 782 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019004" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s7-t5", "type": "umlsterm", "text": [ "renal failure" ], "offsets": [ [ 792, 805 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035078" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s7-t6", "type": "umlsterm", "text": [ "diabetic glomerulosclerosis" ], "offsets": [ [ 813, 840 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017667" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s8-t1", "type": "umlsterm", "text": [ "pathogenesis" ], "offsets": [ [ 869, 881 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0543483" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s8-t2", "type": "umlsterm", "text": [ "calciphylaxis" ], "offsets": [ [ 885, 898 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006666" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s8-t3", "type": "umlsterm", "text": [ "diagnosis" ], "offsets": [ [ 912, 921 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011900" }, { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s8-t4", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 924, 933 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerHautarzt.00510036.eng.abstr-s8-t5", "type": "umlsterm", "text": [ "literature" ], "offsets": [ [ 984, 994 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023866" } ] } ]

[]

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"DerHautarzt.00510036.eng.abstr-s8-t3", "arg2_id": "DerHautarzt.00510036.eng.abstr-s8-t1", "normalized": [] }, { "id": "DerHautarzt.00510036.eng.abstr-s7-r14-t1.1-t6.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510036.eng.abstr-s8-t1", "arg2_id": "DerHautarzt.00510036.eng.abstr-s7-t6", "normalized": [] }, { "id": "DerHautarzt.00510036.eng.abstr-s7-r15-t4.1-t6.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510036.eng.abstr-s8-t4", "arg2_id": "DerHautarzt.00510036.eng.abstr-s7-t6", "normalized": [] }, { "id": "DerHautarzt.00510036.eng.abstr-s7-r16-t6.1-t1.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510036.eng.abstr-s7-t6", "arg2_id": "DerHautarzt.00510036.eng.abstr-s8-t1", "normalized": [] }, { "id": "DerHautarzt.00510036.eng.abstr-s7-r17-t6.1-t1.1", "type": "occurs_in", "arg1_id": "DerHautarzt.00510036.eng.abstr-s7-t6", "arg2_id": "DerHautarzt.00510036.eng.abstr-s8-t1", "normalized": [] }, { "id": "DerHautarzt.00510036.eng.abstr-s7-r18-t1.1-t4.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510036.eng.abstr-s8-t1", "arg2_id": "DerHautarzt.00510036.eng.abstr-s8-t4", "normalized": [] }, { "id": "DerHautarzt.00510036.eng.abstr-s7-r19-t1.1-t3.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510036.eng.abstr-s8-t1", "arg2_id": "DerHautarzt.00510036.eng.abstr-s8-t3", "normalized": [] }, { "id": "DerHautarzt.00510036.eng.abstr-s7-r20-t4.1-t3.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510036.eng.abstr-s8-t4", "arg2_id": "DerHautarzt.00510036.eng.abstr-s8-t3", "normalized": [] }, { "id": "DerHautarzt.00510036.eng.abstr-s7-r21-t4.1-t1.2", "type": "associated_with", "arg1_id": "DerHautarzt.00510036.eng.abstr-s8-t4", "arg2_id": "DerHautarzt.00510036.eng.abstr-s7-t1", "normalized": [] }, { "id": "DerHautarzt.00510036.eng.abstr-s8-r1-t3.2-t1.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510036.eng.abstr-s8-t3", "arg2_id": "DerHautarzt.00510036.eng.abstr-s8-t1", "normalized": [] }, { "id": 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"normalized": [] }, { "id": "DerHautarzt.00510036.eng.abstr-s8-r9-t1.1-t3.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510036.eng.abstr-s8-t1", "arg2_id": "DerHautarzt.00510036.eng.abstr-s8-t3", "normalized": [] } ]

DerHautarzt.00510041.eng.abstr

[ { "id": "DerHautarzt.00510041.eng.abstr-passage-0", "type": "abstract", "text": [ "Cutaneous metastases from a leiomyosarcoma of the testicular tunica albuginea are very rare . Primary leiomyosarcomas in this site are uncommen and furthermore cutaneous metastases develop only in 1,4% of all malignant tumors of the internal organs [ 10 ] . A 71 year old patient with such a sarcoma underwent primary excision . Nine months later multiple , firm , nodules were identified as cutaneous metastases . Further staging revealed already extensive , diffuse pulmonary and bony metastases without contiguous or regional lymph node involvement ." ], "offsets": [ [ 0, 553 ] ] } ]

[ { "id": "DerHautarzt.00510041.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "metastases" ], "offsets": [ [ 10, 20 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027627" } ] }, { "id": "DerHautarzt.00510041.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "leiomyosarcoma" ], "offsets": [ [ 28, 42 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023269" } ] }, { "id": "DerHautarzt.00510041.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "leiomyosarcomas" ], "offsets": [ [ 102, 117 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023269" } ] }, { "id": "DerHautarzt.00510041.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "metastases" ], "offsets": [ [ 170, 180 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027627" } ] }, { "id": "DerHautarzt.00510041.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "malignant" ], "offsets": [ [ 209, 218 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006826" } ] }, { "id": "DerHautarzt.00510041.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "tumors" ], "offsets": [ [ 219, 225 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerHautarzt.00510041.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "malignant tumors" ], "offsets": [ [ 209, 225 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006826" } ] }, { "id": "DerHautarzt.00510041.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "old" ], "offsets": [ [ 268, 271 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0331059" } ] }, { "id": "DerHautarzt.00510041.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 272, 279 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510041.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "sarcoma" ], "offsets": [ [ 292, 299 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036210" } ] }, { "id": "DerHautarzt.00510041.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "metastases" ], "offsets": [ [ 402, 412 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027627" } ] }, { "id": "DerHautarzt.00510041.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "metastases" ], "offsets": [ [ 487, 497 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027627" } ] }, { "id": "DerHautarzt.00510041.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "lymph" ], "offsets": [ [ 529, 534 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024202" } ] }, { "id": "DerHautarzt.00510041.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "lymph node" ], "offsets": [ [ 529, 539 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024204" } ] } ]

[]

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DerHautarzt.00510059.eng.abstr

[ { "id": "DerHautarzt.00510059.eng.abstr-passage-0", "type": "abstract", "text": [ "Persistent cellular microchimerism might play a role in the pathogenesis of systemic sclerosis ( SSc ) . Microchimerism results from the traffic of fetal cells through the placenta during pregnancy into the maternal circulation and their survival due to HLA class II compatibility . In female SSc patients the presence of fetal CD3-positive T-cells in the maternal circulation and of fetal cells in the affected skin tissue has been identified through y chromosome specific DNA sequences . The persistent microchimerism might cause SSc in certain patients by initiating a fetal anti-maternal Graft-versus-host-like response ." ], "offsets": [ [ 0, 625 ] ] } ]

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[]

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DerHautarzt.00510063.eng.abstr

[ { "id": "DerHautarzt.00510063.eng.abstr-passage-0", "type": "abstract", "text": [ "Mycophenolate mofetil represents a new immunosuppressive drug . Several case reports have shown that mycophenolate mofetil has a good therapeutic effect in patients with psoriasis and autoimmune dermatoses . Mycophenolate mofetil is a morpholine ester of mycophenolic acid which was shown in the 1970s to be effective in patients with severe psoriasis . Mycophenolate mofetil has an increased bioavailability as compared to mycophenolic acid and thereby an improved therapeutic window . Currently , mycophenolate mofetil is indiated for the prevention of organ rejection in transplant patients . The mode of action and the pharmacology of mycophenolate mofetil are reviewed and the current clinical experience with this immunosuppressive drug for dermatological disorders is summarized ." ], "offsets": [ [ 0, 787 ] ] } ]

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"C0209368" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "mycophenolic acid" ], "offsets": [ [ 424, 441 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026933" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "prevention" ], "offsets": [ [ 541, 551 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0687732" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "rejection" ], "offsets": [ [ 561, 570 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035015" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "transplant" ], "offsets": [ [ 574, 584 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0332835" }, { "db_name": "UMLS", "db_id": "C0040733" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 585, 593 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, 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"DerHautarzt.00510063.eng.abstr-s6-t5", "type": "umlsterm", "text": [ "mycophenolate mofetil" ], "offsets": [ [ 639, 660 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0209368" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s6-t6", "type": "umlsterm", "text": [ "immunosuppressive drug" ], "offsets": [ [ 720, 742 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021081" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s6-t7", "type": "umlsterm", "text": [ "dermatological disorders" ], "offsets": [ [ 747, 771 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037274" } ] }, { "id": "DerHautarzt.00510063.eng.abstr-s6-t8", "type": "umlsterm", "text": [ "mode of action" ], "offsets": [ [ 600, 614 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0205464" } ] } ]

[]

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DerHautarzt.00510070.eng.abstr

[ { "id": "DerHautarzt.00510070.eng.abstr-passage-0", "type": "abstract", "text": [ "Objective . The volume flow in the common femoral vein ( SV ) as a representative parameter of the venous hemodynamics of the leg can be measured using duplex-sonography . A direct correlation between the SV-data and the clinical grade of the venous disease was postulated ." ], "offsets": [ [ 0, 274 ] ] } ]

[ { "id": "DerHautarzt.00510070.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Objective" ], "offsets": [ [ 0, 9 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018017" } ] }, { "id": "DerHautarzt.00510070.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "vein" ], "offsets": [ [ 50, 54 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042449" } ] }, { "id": "DerHautarzt.00510070.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "hemodynamics" ], "offsets": [ [ 106, 118 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019010" } ] }, { "id": "DerHautarzt.00510070.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "leg" ], "offsets": [ [ 126, 129 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023216" } ] }, { "id": "DerHautarzt.00510070.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "femoral vein" ], "offsets": [ [ 42, 54 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015809" } ] }, { "id": "DerHautarzt.00510070.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "direct" ], "offsets": [ [ 174, 180 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0700157" } ] }, { "id": "DerHautarzt.00510070.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 250, 257 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] } ]

[]

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DerHautarzt.00510075.eng.abstr

[ { "id": "DerHautarzt.00510075.eng.abstr-passage-0", "type": "abstract", "text": [ "Scabies is an infectious parasitic skin disease with a notable rising incidence in Germany . The disease is usually transmitted by close physical contact , but indirect spread e.g. by bedding is also possible . Due to its contagiousness , introduction of scabies into crowding living facilities , such as dormitories or kindergartens , can easily cause an epidemic outbreak . We describe an epidemic of scabies in a workshop for handicapped people in February 1998. A worker with severe scabies reported that numerous colleagues in both workshop and the associated hostel had complained of pruritus for months and that some of them already had undergone scabicide treatment . The number of contacts ( staff , colleagues , friends , attendants , family ) of our patient and the other already affected people was more than 460. The management of the workshop asked for help in handling the epidemic . We describe the cooperative efforts of the management , as well as hospital and private dermatologists , to evaluate all potential contacts and present a concept of treatment for the termination of such an epidemic outbreak of scabies ." ], "offsets": [ [ 0, 1135 ] ] } ]

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"DerHautarzt.00510075.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "Germany" ], "offsets": [ [ 83, 90 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017480" } ] }, { "id": "DerHautarzt.00510075.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "skin disease" ], "offsets": [ [ 35, 47 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037274" } ] }, { "id": "DerHautarzt.00510075.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "parasitic skin disease" ], "offsets": [ [ 25, 47 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037280" } ] }, { "id": "DerHautarzt.00510075.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 97, 104 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510075.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "bedding" ], "offsets": [ [ 184, 191 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004914" } ] }, { "id": "DerHautarzt.00510075.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "scabies" ], "offsets": [ [ 255, 262 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036262" } ] }, { "id": "DerHautarzt.00510075.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "epidemic" ], "offsets": [ [ 356, 364 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014499" }, { "db_name": "UMLS", "db_id": "C0220823" } ] }, { "id": "DerHautarzt.00510075.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "outbreak" ], "offsets": [ [ 365, 373 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012652" }, { "db_name": "UMLS", "db_id": "C0220888" } ] }, { "id": "DerHautarzt.00510075.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "epidemic" ], "offsets": [ [ 391, 399 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014499" }, { "db_name": "UMLS", "db_id": "C0220823" } ] }, { "id": "DerHautarzt.00510075.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "scabies" ], "offsets": [ [ 403, 410 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036262" } ] }, { "id": "DerHautarzt.00510075.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "workshop" ], "offsets": [ [ 416, 424 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242262" } ] }, { "id": "DerHautarzt.00510075.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "handicapped" ], "offsets": [ [ 429, 440 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018576" } ] }, { "id": "DerHautarzt.00510075.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "people" ], "offsets": [ [ 441, 447 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027361" } ] }, { "id": "DerHautarzt.00510075.eng.abstr-s4-t6", "type": "umlsterm", "text": [ "worker" ], "offsets": [ [ 468, 474 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024752" } ] }, { "id": "DerHautarzt.00510075.eng.abstr-s4-t7", "type": "umlsterm", "text": [ "scabies" ], "offsets": [ [ 487, 494 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036262" } ] }, { "id": "DerHautarzt.00510075.eng.abstr-s4-t8", "type": "umlsterm", "text": [ "workshop" ], "offsets": [ [ 537, 545 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242262" } ] }, { "id": "DerHautarzt.00510075.eng.abstr-s4-t9", "type": "umlsterm", "text": [ "pruritus" ], "offsets": [ [ 590, 598 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033778" }, { "db_name": "UMLS", "db_id": "C0033774" } ] }, { "id": "DerHautarzt.00510075.eng.abstr-s4-t10", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 664, 673 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerHautarzt.00510075.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "friends" ], "offsets": [ [ 722, 729 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0079382" } ] }, { "id": "DerHautarzt.00510075.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "family" ], "offsets": [ [ 745, 751 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015576" } ] }, { "id": "DerHautarzt.00510075.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 761, 768 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510075.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "people" ], "offsets": [ [ 800, 806 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027361" } ] }, { "id": "DerHautarzt.00510075.eng.abstr-s5-t5", "type": "umlsterm", "text": [ "workshop" ], "offsets": [ [ 848, 856 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242262" } ] }, { "id": "DerHautarzt.00510075.eng.abstr-s5-t6", "type": "umlsterm", "text": [ "epidemic" ], "offsets": [ [ 888, 896 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014499" }, { "db_name": "UMLS", "db_id": "C0220823" } ] }, { "id": "DerHautarzt.00510075.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "efforts" ], "offsets": [ [ 927, 934 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015264" } ] }, { "id": "DerHautarzt.00510075.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "hospital" ], "offsets": [ [ 966, 974 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019994" } ] }, { "id": "DerHautarzt.00510075.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 1064, 1073 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerHautarzt.00510075.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "epidemic" ], "offsets": [ [ 1105, 1113 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014499" }, { "db_name": "UMLS", "db_id": "C0220823" } ] }, { "id": "DerHautarzt.00510075.eng.abstr-s6-t5", "type": "umlsterm", "text": [ "outbreak" ], "offsets": [ [ 1114, 1122 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012652" }, { "db_name": "UMLS", "db_id": "C0220888" } ] }, { "id": "DerHautarzt.00510075.eng.abstr-s6-t6", "type": "umlsterm", "text": [ "scabies" ], "offsets": [ [ 1126, 1133 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036262" } ] } ]

[]

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DerHautarzt.00510086.eng.abstr

[ { "id": "DerHautarzt.00510086.eng.abstr-passage-0", "type": "abstract", "text": [ "Two boys aged 6 and 9 years presented with persistent sharply circumscribed perianal erythema . One boy had no other skin findings ; the other had additional lesions on the genitalia and extremities . The diagnosis of perianal streptococcal dermatitis was made after streptococci were cultured from skin swabs . This primarily childhood disease should be distinguished from candidiasis and perianal atopic dermatitis . As in our cases , topical therapy is usually ineffective and oral penicillin remains the treatment of choice ." ], "offsets": [ [ 0, 529 ] ] } ]

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[]

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DerHautarzt.00510090.eng.abstr

[ { "id": "DerHautarzt.00510090.eng.abstr-passage-0", "type": "abstract", "text": [ "Interstitial granulomatous dermatitis with arthritis is a rare dermatologic disorder seen in patients suffering from diseases in which circulating immune complexes occur . The typical cutaneous signs are linear cords usually located on the lateral aspect of the trunk . The characteristic , although not specific , histology reveals a dense diffuse infiltrate composed mostly of histiocytes , accompanied by neutrophils and eosinophils , and degenerated collagen surrounded by palisades of histiocytes . We discuss this disorder and its differential diagnosis ." ], "offsets": [ [ 0, 561 ] ] } ]

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[]

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DerHautarzt.00510095.eng.abstr

[ { "id": "DerHautarzt.00510095.eng.abstr-passage-0", "type": "abstract", "text": [ "Autosomal recessive inheritance , intrauterine growth retardation , short stature , microcephaly , distinct facial dysmorphism , psychomotoric retardation , and often uncharacterized eczematous skin lesions distinguish the rare Dubowitz syndrome . Here a pair of monozygotic twins with Dubowitz syndrome and clear-cut atopic eczema is presented ." ], "offsets": [ [ 0, 346 ] ] } ]

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[]

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DerHautarzt.00510101.eng.abstr

[ { "id": "DerHautarzt.00510101.eng.abstr-passage-0", "type": "abstract", "text": [ "Andy Warhol underwent dermabrasion in 1957 because of a nasal skin lesion , which is best diagnosed as a rhinophyma on the basis of the available biographical literature . Throughout his creative life , the artist worked on different aspects of plastic surgery especially in the nasal area . As one of the founders of Pop-Art , Warhol left essential marks on the modern society and influenced our standards of aesthetic shapes ." ], "offsets": [ [ 0, 428 ] ] } ]

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[]

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DerHautarzt.00510147.eng.abstr

[ { "id": "DerHautarzt.00510147.eng.abstr-passage-0", "type": "abstract", "text": [ "Vulvodynia is a complex syndrome of chronic vulvar pain . It is divided into several subtypes : 1. cyclic vulvovaginitis ( pain occurs after coitus ) , 2. vulvar vestibulitis syndrome ( pain mainly with intercourse ) , 3. dysaesthetic vulvodynia ( psychosomatic ; diagnosis of exclusion ) , 4. vulvar dermatoses ( e.g. pemphigus vulgaris , contact dermatitis ) . Additional causes have been described in single cases . Though vulvodynia is often accompanied by psychological distress , somatic causes have to be considered in each case ." ], "offsets": [ [ 0, 537 ] ] } ]

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[]

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DerHautarzt.00510152.eng.abstr

[ { "id": "DerHautarzt.00510152.eng.abstr-passage-0", "type": "abstract", "text": [ "The neodymium : yttrium-aluminium-garnet- ( Nd : YAG ) laser is one of the most versatile and interesting lasers in dermatological laser medicine . Almost no other laser has such a wide spectrum of applications . Depending on wave length ( 1064 nm , frequency-doubled 532 nm ) and mode ( continuous , Q-switched , longpulsed ) , benign pigmented lesions ( tattoos , traumatic tattoos , naevus of Ota , cafe-aut-lait-macules , lentigines ) and vascular lesions ( hemangiomas , portwine stains , essential teleangiectasias , angiomas ) can be treated . Additionally this laser has been occasionally used to remove Kaposi sarcomas and epithelial skin tumors ." ], "offsets": [ [ 0, 656 ] ] } ]

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[]

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DerHautarzt.00510159.eng.abstr

[ { "id": "DerHautarzt.00510159.eng.abstr-passage-0", "type": "abstract", "text": [ "Since the availability of protease inhibitors in 1997 , there has been a great change in antiretroviral therapy but also new long term side effects have emerged , mainly metabolic changes such as hypertriglyceridemia , hypercholesterinemia and hyperglycemia . Besides , fat redistribution has been observed . Fat wastes in the face and limbs but accumulates in the adipose tissue of the dorsocervical and abdominal region and the breasts . The mechanism of these changes remains unclear . For therapy a protease inhibitor free therapy or lipid lowering drugs may be tried . 29 of our 224 patients developed lipodystrophy . 27 of these patients had been treated with a protease inhibitor ( 17 patients with indinavir ) ; 2 of the patients had never received protease inhibitors ." ], "offsets": [ [ 0, 778 ] ] } ]

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[]

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DerHautarzt.00510164.eng.abstr

[ { "id": "DerHautarzt.00510164.eng.abstr-passage-0", "type": "abstract", "text": [ "Background and Objectives . Treatment of pruritus as observed in many dermatological and internal diseases may be very often disappointing . There are many reports describing the topical use of capsaicin , the pungent agent in red pepper . Long term administration of capsaicin depletes neuropeptides in unmyelinated , polymodal C-type and small myelinated A-type cutaneous nerves that conduct pruritus and pain ." ], "offsets": [ [ 0, 413 ] ] } ]

[ { "id": "DerHautarzt.00510164.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Objectives" ], "offsets": [ [ 15, 25 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018017" } ] }, { "id": "DerHautarzt.00510164.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "Treatment" ], "offsets": [ [ 28, 37 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerHautarzt.00510164.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "pruritus" ], "offsets": [ [ 41, 49 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033778" }, { "db_name": "UMLS", "db_id": "C0033774" } ] }, { "id": "DerHautarzt.00510164.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "diseases" ], "offsets": [ [ 98, 106 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510164.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "use" ], "offsets": [ [ 187, 190 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042153" } ] }, { "id": "DerHautarzt.00510164.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "capsaicin" ], "offsets": [ [ 194, 203 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006931" } ] }, { "id": "DerHautarzt.00510164.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "red pepper" ], "offsets": [ [ 227, 237 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0446306" } ] }, { "id": "DerHautarzt.00510164.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "administration" ], "offsets": [ [ 250, 264 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001554" } ] }, { "id": "DerHautarzt.00510164.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "capsaicin" ], "offsets": [ [ 268, 277 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006931" } ] }, { "id": "DerHautarzt.00510164.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "neuropeptides" ], "offsets": [ [ 287, 300 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027895" } ] }, { "id": "DerHautarzt.00510164.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "nerves" ], "offsets": [ [ 374, 380 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027769" } ] }, { "id": "DerHautarzt.00510164.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "conduct" ], "offsets": [ [ 386, 393 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004927" } ] }, { "id": "DerHautarzt.00510164.eng.abstr-s4-t6", "type": "umlsterm", "text": [ "pruritus" ], "offsets": [ [ 394, 402 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033778" }, { "db_name": "UMLS", "db_id": "C0033774" } ] }, { "id": "DerHautarzt.00510164.eng.abstr-s4-t7", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 407, 411 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] } ]

[]

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DerHautarzt.00510173.eng.abstr

[ { "id": "DerHautarzt.00510173.eng.abstr-passage-0", "type": "abstract", "text": [ "Background and Objective . Keratoacanthoma are benign epithelial tumors . The aim of this study was to determine the effects of interferon alpha on keratoacanthoma ." ], "offsets": [ [ 0, 165 ] ] } ]

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[]

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DerHautarzt.00510187.eng.abstr

[ { "id": "DerHautarzt.00510187.eng.abstr-passage-0", "type": "abstract", "text": [ "Radiation-induced acne is a rare , clinically and pathogenetically ill-defined acneiform dermatosis with special features that may occur in irradiated skin areas especially after high doses of deeply penetrating radiation . We report on a patient with an oropharyngeal carcinoma who developed severe radiation-induced acne including comedones and cysts as well as few inflammatory papules and pustules in a skin area irradiated with up to 63 gray of a 6 MeV photon beam . Acnegenic drugs may precipitate the disease ; our patient was on longterm therapy with carbamazepine whose acnegenic potency is less well documented than that of testosterone or glucocorticoids . Treatment of radiation-induced acne is comedolytic ; topical retinoids are especially valuable ." ], "offsets": [ [ 0, 764 ] ] } ]

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[]

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DerHautarzt.00510192.eng.abstr

[ { "id": "DerHautarzt.00510192.eng.abstr-passage-0", "type": "abstract", "text": [ "Pachyonychia congenita ( PC ) is a rare ectodermal dysplasia with variable expression . The condition is usually inherited as an autosomal dominant trait . Several classifications of PC have been proposed . Feinstein and colleagues suggested four clinical types of PC . Type II , the Jackson-Lawler-Syndrome , is characterized by multiple epidermal cysts , palmoplantar bullae and hyperhidrosis as well as natal teeth in addition to the main findings of pachyonychia , palmoplantar hyperkeratosis and follicular keratosis . We report two patients ( father and son ) with Jackson-Lawler-Syndrome and describe in detail pathogenesis , diagnostic criteria and treatment approaches as well as the different classifications of pachyonychia congenita ." ], "offsets": [ [ 0, 746 ] ] } ]

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[]

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DerHautarzt.00510196.eng.abstr

[ { "id": "DerHautarzt.00510196.eng.abstr-passage-0", "type": "abstract", "text": [ "Therapy of Darier disease is rarely satisfactory . Oral retinoids can improve the skin lesions . Because of previous positive results with topical retinoids , which were often not practical because of marked skin irritation , two patients were treated with the new , topical acetylene-retinoid tazarotene in a 0.01% gel preparation . In both patients skin cleared within 2 to 4 weeks . After stopping the medication patients did not develop any new skin lesions for 12 months . In a third patient , healing with tazarotene gel 0.025% was faster than with a topical preparation containing 10% urea . Tazarotene is an important addition to the therapeutic possibilities in Darier disease ." ], "offsets": [ [ 0, 687 ] ] } ]

[ { "id": "DerHautarzt.00510196.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Therapy" ], "offsets": [ [ 0, 7 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerHautarzt.00510196.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 18, 25 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510196.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "Darier disease" ], "offsets": [ [ 11, 25 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022595" } ] }, { "id": "DerHautarzt.00510196.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "retinoids" ], "offsets": [ [ 56, 65 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035339" } ] }, { "id": "DerHautarzt.00510196.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "skin" ], "offsets": [ [ 82, 86 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] }, { "id": "DerHautarzt.00510196.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "retinoids" ], "offsets": [ [ 147, 156 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035339" } ] }, { "id": "DerHautarzt.00510196.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "skin" ], "offsets": [ [ 208, 212 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] }, { "id": "DerHautarzt.00510196.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 230, 238 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510196.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "acetylene-retinoid" ], "offsets": [ [ 275, 293 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001052" } ] }, { "id": "DerHautarzt.00510196.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "acetylene-retinoid" ], "offsets": [ [ 275, 293 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035339" } ] }, { "id": "DerHautarzt.00510196.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "tazarotene" ], "offsets": [ [ 294, 304 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0288792" } ] }, { "id": "DerHautarzt.00510196.eng.abstr-s3-t7", "type": "umlsterm", "text": [ "gel" ], "offsets": [ [ 316, 319 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017243" } ] }, { "id": "DerHautarzt.00510196.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 342, 350 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510196.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "skin" ], "offsets": [ [ 351, 355 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] }, { "id": "DerHautarzt.00510196.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "medication" ], "offsets": [ [ 405, 415 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013227" } ] }, { "id": "DerHautarzt.00510196.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 416, 424 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510196.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "skin" ], "offsets": [ [ 449, 453 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] }, { "id": "DerHautarzt.00510196.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 489, 496 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510196.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "tazarotene" ], "offsets": [ [ 512, 522 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0288792" } ] }, { "id": "DerHautarzt.00510196.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "gel" ], "offsets": [ [ 523, 526 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017243" } ] }, { "id": "DerHautarzt.00510196.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "faster" ], "offsets": [ [ 538, 544 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015663" } ] }, { "id": "DerHautarzt.00510196.eng.abstr-s6-t5", "type": "umlsterm", "text": [ "urea" ], "offsets": [ [ 592, 596 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0041942" } ] }, { "id": "DerHautarzt.00510196.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "Tazarotene" ], "offsets": [ [ 599, 609 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0288792" } ] }, { "id": "DerHautarzt.00510196.eng.abstr-s7-t2", "type": "umlsterm", "text": [ "therapeutic" ], "offsets": [ [ 642, 653 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "DerHautarzt.00510196.eng.abstr-s7-t3", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 678, 685 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510196.eng.abstr-s7-t4", "type": "umlsterm", "text": [ "Darier disease" ], "offsets": [ [ 671, 685 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022595" } ] } ]

[]

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"DerHautarzt.00510196.eng.abstr-s7-t1", "arg2_id": "DerHautarzt.00510196.eng.abstr-s7-t4", "normalized": [] }, { "id": "DerHautarzt.00510196.eng.abstr-s3-r12-t5.1-t1.1", "type": "interacts_with", "arg1_id": "DerHautarzt.00510196.eng.abstr-s6-t5", "arg2_id": "DerHautarzt.00510196.eng.abstr-s7-t1", "normalized": [] }, { "id": "DerHautarzt.00510196.eng.abstr-s3-r13-t2.1-t5.1", "type": "produces", "arg1_id": "DerHautarzt.00510196.eng.abstr-s7-t2", "arg2_id": "DerHautarzt.00510196.eng.abstr-s6-t5", "normalized": [] }, { "id": "DerHautarzt.00510196.eng.abstr-s3-r14-t6.1-t4.1", "type": "interacts_with", "arg1_id": "DerHautarzt.00510196.eng.abstr-s3-t6", "arg2_id": "DerHautarzt.00510196.eng.abstr-s7-t4", "normalized": [] }, { "id": "DerHautarzt.00510196.eng.abstr-s3-r15-t5.1-t6.1", "type": "interacts_with", "arg1_id": "DerHautarzt.00510196.eng.abstr-s6-t5", "arg2_id": "DerHautarzt.00510196.eng.abstr-s3-t6", "normalized": [] }, { "id": "DerHautarzt.00510196.eng.abstr-s5-r1-t1.1-t3.1", "type": "disrupts", "arg1_id": "DerHautarzt.00510196.eng.abstr-s7-t1", "arg2_id": "DerHautarzt.00510196.eng.abstr-s7-t3", "normalized": [] }, { "id": "DerHautarzt.00510196.eng.abstr-s6-r1-t4.1-t1.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510196.eng.abstr-s7-t4", "arg2_id": "DerHautarzt.00510196.eng.abstr-s7-t1", "normalized": [] }, { "id": "DerHautarzt.00510196.eng.abstr-s6-r2-t1.1-t4.1", "type": "performs", "arg1_id": "DerHautarzt.00510196.eng.abstr-s7-t1", "arg2_id": "DerHautarzt.00510196.eng.abstr-s7-t4", "normalized": [] }, { "id": "DerHautarzt.00510196.eng.abstr-s6-r3-t2.1-t5.1", "type": "interacts_with", "arg1_id": "DerHautarzt.00510196.eng.abstr-s7-t2", "arg2_id": "DerHautarzt.00510196.eng.abstr-s6-t5", "normalized": [] }, { "id": "DerHautarzt.00510196.eng.abstr-s6-r4-t4.1-t1.1", "type": "affects", "arg1_id": "DerHautarzt.00510196.eng.abstr-s7-t4", "arg2_id": "DerHautarzt.00510196.eng.abstr-s7-t1", "normalized": [] }, { "id": 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"id": "DerHautarzt.00510196.eng.abstr-s7-r3-t1.1-t3.1", "type": "affects", "arg1_id": "DerHautarzt.00510196.eng.abstr-s7-t1", "arg2_id": "DerHautarzt.00510196.eng.abstr-s7-t3", "normalized": [] }, { "id": "DerHautarzt.00510196.eng.abstr-s7-r4-t3.1-t1.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510196.eng.abstr-s7-t3", "arg2_id": "DerHautarzt.00510196.eng.abstr-s7-t1", "normalized": [] }, { "id": "DerHautarzt.00510196.eng.abstr-s7-r5-t1.1-t3.1", "type": "diagnoses", "arg1_id": "DerHautarzt.00510196.eng.abstr-s7-t1", "arg2_id": "DerHautarzt.00510196.eng.abstr-s7-t3", "normalized": [] }, { "id": "DerHautarzt.00510196.eng.abstr-s7-r6-t1.1-t4.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510196.eng.abstr-s7-t1", "arg2_id": "DerHautarzt.00510196.eng.abstr-s7-t4", "normalized": [] }, { "id": "DerHautarzt.00510196.eng.abstr-s7-r7-t1.1-t4.1", "type": "affects", "arg1_id": "DerHautarzt.00510196.eng.abstr-s7-t1", "arg2_id": "DerHautarzt.00510196.eng.abstr-s7-t4", "normalized": [] }, { "id": "DerHautarzt.00510196.eng.abstr-s7-r8-t1.1-t3.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510196.eng.abstr-s7-t1", "arg2_id": "DerHautarzt.00510196.eng.abstr-s7-t3", "normalized": [] } ]

DerHautarzt.00510201.eng.abstr

[ { "id": "DerHautarzt.00510201.eng.abstr-passage-0", "type": "abstract", "text": [ "We describe a young man presenting with dreadlocks . There are remarkable similarities with the so called plica polonica , that historically had been treated with long courses of mercury . Apparently very important in the 18th century , the interest for this hairdisorder appears to be lost in specialized medical literature . In contrast dreadlocks , a recent hairstyle are frequently encountered . Lack of other sources various websites provide dermatologists with answers to questions regarding complications . Fortunately a simply haircut is today treatment enough ." ], "offsets": [ [ 0, 570 ] ] } ]

[ { "id": "DerHautarzt.00510201.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "man" ], "offsets": [ [ 20, 23 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025266" }, { "db_name": "UMLS", "db_id": "C0024554" } ] }, { "id": "DerHautarzt.00510201.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "mercury" ], "offsets": [ [ 179, 186 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025424" } ] }, { "id": "DerHautarzt.00510201.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "hairdisorder" ], "offsets": [ [ 259, 271 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018494" } ] }, { "id": "DerHautarzt.00510201.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "hairdisorder" ], "offsets": [ [ 259, 271 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510201.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "literature" ], "offsets": [ [ 314, 324 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023866" } ] }, { "id": "DerHautarzt.00510201.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "contrast" ], "offsets": [ [ 330, 338 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0110625" } ] }, { "id": "DerHautarzt.00510201.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "complications" ], "offsets": [ [ 498, 511 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009566" } ] }, { "id": "DerHautarzt.00510201.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 552, 561 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] } ]

[]

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DerHautarzt.00510223.eng.abstr

[ { "id": "DerHautarzt.00510223.eng.abstr-passage-0", "type": "abstract", "text": [ "Since the skin and its appendages are androgen-dependent , male hypogonadism can be associated with dermatologically relevent lesions . The skin surface of hypogonadal patients is thin and shows increased wrinkles . In cases of prepubertal hypogonadism , severe acne does not occur . In contrast , patients may suffer from sebostasis due to missing stimulation of the sebaceous glands . The genital skin does not show pigmentation , which normaly develops during puberty ; the integument is pale . Hair growth on breast , pubia , axilla , face and integument is reduced ; patients do not present with typical androgenetic alopecia . In addition to these features , dermatological diseases caused by treatment of the hypogonadism or drug-induced skin reactions have to be considered . While drug reactions to oral or intramuscular androgens or gonadotropins are rare , irritative or allergic skin lesions are observed frequently , especially in cases of non-scrotal transdermal therapeutic systems with testosterone . A variety of syndromes include dermatological symptoms associated with male hypogonadism ; however , the prevalence of these syndromes is low ." ], "offsets": [ [ 0, 1160 ] ] } ]

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[]

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DerHautarzt.00510231.eng.abstr

[ { "id": "DerHautarzt.00510231.eng.abstr-passage-0", "type": "abstract", "text": [ "Background and objective . Cryosurgery is a widely accepted modality for the treatment of capillary hemangiomas of the newborn . However , no studies clearly supporting its effectivity are available ." ], "offsets": [ [ 0, 200 ] ] } ]

[ { "id": "DerHautarzt.00510231.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "objective" ], "offsets": [ [ 15, 24 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018017" } ] }, { "id": "DerHautarzt.00510231.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "Cryosurgery" ], "offsets": [ [ 27, 38 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010408" } ] }, { "id": "DerHautarzt.00510231.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 77, 86 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerHautarzt.00510231.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "capillary" ], "offsets": [ [ 90, 99 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006901" } ] }, { "id": "DerHautarzt.00510231.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "hemangiomas" ], "offsets": [ [ 100, 111 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018916" } ] }, { "id": "DerHautarzt.00510231.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "newborn" ], "offsets": [ [ 119, 126 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021289" } ] }, { "id": "DerHautarzt.00510231.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "capillary hemangiomas" ], "offsets": [ [ 90, 111 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0206733" } ] } ]

[]

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DerHautarzt.00510239.eng.abstr

[ { "id": "DerHautarzt.00510239.eng.abstr-passage-0", "type": "abstract", "text": [ "Background and objective . The Information Network of Departments of Dermatology ( IVDK ) centrally collects patch tests results in cooperation with the German Contact Dermatitis Research Group ( DKG ) . Data of patients , who underwent patch testing to evaluate otitis externa were analyzed ." ], "offsets": [ [ 0, 293 ] ] } ]

[ { "id": "DerHautarzt.00510239.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "objective" ], "offsets": [ [ 15, 24 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018017" } ] }, { "id": "DerHautarzt.00510239.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "Dermatology" ], "offsets": [ [ 69, 80 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011627" } ] }, { "id": "DerHautarzt.00510239.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "tests" ], "offsets": [ [ 115, 120 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0076174" } ] }, { "id": "DerHautarzt.00510239.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "Dermatitis" ], "offsets": [ [ 168, 178 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011603" } ] }, { "id": "DerHautarzt.00510239.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "Research" ], "offsets": [ [ 179, 187 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035168" } ] }, { "id": "DerHautarzt.00510239.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "Information Network" ], "offsets": [ [ 31, 50 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021419" } ] }, { "id": "DerHautarzt.00510239.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "patch tests" ], "offsets": [ [ 109, 120 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030646" } ] }, { "id": "DerHautarzt.00510239.eng.abstr-s2-t7", "type": "umlsterm", "text": [ "Contact Dermatitis" ], "offsets": [ [ 160, 178 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011616" } ] }, { "id": "DerHautarzt.00510239.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 212, 220 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510239.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "testing" ], "offsets": [ [ 243, 250 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039593" } ] }, { "id": "DerHautarzt.00510239.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "otitis" ], "offsets": [ [ 263, 269 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029877" } ] }, { "id": "DerHautarzt.00510239.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "otitis externa" ], "offsets": [ [ 263, 277 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029878" } ] } ]

[]

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"arg2_id": "DerHautarzt.00510239.eng.abstr-s2-t7", "normalized": [] }, { "id": "DerHautarzt.00510239.eng.abstr-s2-r11-t4.1-t7.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510239.eng.abstr-s3-t4", "arg2_id": "DerHautarzt.00510239.eng.abstr-s2-t7", "normalized": [] }, { "id": "DerHautarzt.00510239.eng.abstr-s2-r12-t2.1-t4.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510239.eng.abstr-s3-t2", "arg2_id": "DerHautarzt.00510239.eng.abstr-s3-t4", "normalized": [] }, { "id": "DerHautarzt.00510239.eng.abstr-s2-r13-t5.1-t2.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510239.eng.abstr-s2-t5", "arg2_id": "DerHautarzt.00510239.eng.abstr-s3-t2", "normalized": [] }, { "id": "DerHautarzt.00510239.eng.abstr-s2-r14-t5.1-t1.1", "type": "issue_in", "arg1_id": "DerHautarzt.00510239.eng.abstr-s2-t5", "arg2_id": "DerHautarzt.00510239.eng.abstr-s3-t1", "normalized": [] }, { "id": "DerHautarzt.00510239.eng.abstr-s2-r15-t7.1-t5.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510239.eng.abstr-s2-t7", "arg2_id": "DerHautarzt.00510239.eng.abstr-s2-t5", "normalized": [] }, { "id": "DerHautarzt.00510239.eng.abstr-s2-r16-t5.1-t2.1", "type": "causes", "arg1_id": "DerHautarzt.00510239.eng.abstr-s2-t5", "arg2_id": "DerHautarzt.00510239.eng.abstr-s3-t2", "normalized": [] }, { "id": "DerHautarzt.00510239.eng.abstr-s2-r17-t5.1-t2.1", "type": "analyzes", "arg1_id": "DerHautarzt.00510239.eng.abstr-s2-t5", "arg2_id": "DerHautarzt.00510239.eng.abstr-s3-t2", "normalized": [] }, { "id": "DerHautarzt.00510239.eng.abstr-s2-r18-t7.1-t4.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510239.eng.abstr-s2-t7", "arg2_id": "DerHautarzt.00510239.eng.abstr-s3-t4", "normalized": [] }, { "id": "DerHautarzt.00510239.eng.abstr-s2-r19-t2.1-t7.1", "type": "diagnoses", "arg1_id": "DerHautarzt.00510239.eng.abstr-s3-t2", "arg2_id": "DerHautarzt.00510239.eng.abstr-s2-t7", "normalized": [] }, { "id": "DerHautarzt.00510239.eng.abstr-s2-r20-t4.1-t1.1", "type": "method_of", "arg1_id": "DerHautarzt.00510239.eng.abstr-s3-t4", "arg2_id": "DerHautarzt.00510239.eng.abstr-s3-t1", "normalized": [] }, { "id": "DerHautarzt.00510239.eng.abstr-s2-r21-t2.1-t1.1", "type": "issue_in", "arg1_id": "DerHautarzt.00510239.eng.abstr-s3-t2", "arg2_id": "DerHautarzt.00510239.eng.abstr-s3-t1", "normalized": [] }, { "id": "DerHautarzt.00510239.eng.abstr-s3-r1-t4.1-t1.1", "type": "occurs_in", "arg1_id": "DerHautarzt.00510239.eng.abstr-s3-t4", "arg2_id": "DerHautarzt.00510239.eng.abstr-s3-t1", "normalized": [] }, { "id": "DerHautarzt.00510239.eng.abstr-s3-r2-t4.1-t2.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510239.eng.abstr-s3-t4", "arg2_id": "DerHautarzt.00510239.eng.abstr-s3-t2", "normalized": [] }, { "id": "DerHautarzt.00510239.eng.abstr-s3-r3-t1.1-t2.1", "type": "performs", "arg1_id": "DerHautarzt.00510239.eng.abstr-s3-t1", "arg2_id": "DerHautarzt.00510239.eng.abstr-s3-t2", "normalized": [] }, { "id": "DerHautarzt.00510239.eng.abstr-s3-r4-t2.1-t1.1", "type": "occurs_in", "arg1_id": "DerHautarzt.00510239.eng.abstr-s3-t2", "arg2_id": "DerHautarzt.00510239.eng.abstr-s3-t1", "normalized": [] }, { "id": "DerHautarzt.00510239.eng.abstr-s3-r5-t2.1-t4.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510239.eng.abstr-s3-t2", "arg2_id": "DerHautarzt.00510239.eng.abstr-s3-t4", "normalized": [] } ]

DerHautarzt.00510244.eng.abstr

[ { "id": "DerHautarzt.00510244.eng.abstr-passage-0", "type": "abstract", "text": [ "Background and objective . In 1970 Ralph W. Grover described a clinicopathologic entity characterized by pruritic keratotic papules and papulovesicles predominantly on the trunk , disappearing spontaneously after a few weeks or months and demonstrating the histological features of epidermal acantholysis . The etiology remains unknown ; sweating , heat and sunlight are suspected trigger factors . In our survey the clinical spectrum of the disease will be examined ." ], "offsets": [ [ 0, 468 ] ] } ]

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[]

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DerHautarzt.00510256.eng.abstr

[ { "id": "DerHautarzt.00510256.eng.abstr-passage-0", "type": "abstract", "text": [ "Both herpes simplex and herpes zoster are not uncommon in patients affected by malignant lymphoma or leukemia . Of particular interest , the herpetic lesions may be followed by specific cutaneous infiltrates . We report on a patient with a centrocytic-centroblastic non-Hodgkin lymphoma who showed primary skin infiltrates within the area affected by herpes simplex . After effective therapy with aciclovir , papules and plaques developed at the site of the herpetic scars . Histologic investigation confirmed dense B-lymphocytic infiltrates with immunoglobulin light chain restriction and a granulomatous reaction . Although the chemotherapeutical regiment was modified , the patient died one month later of a lethal blast crisis . The occurrence of so called isotopic skin reactions and their prognostic significance is discussed ." ], "offsets": [ [ 0, 833 ] ] } ]

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], "offsets": [ [ 79, 88 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006826" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "lymphoma" ], "offsets": [ [ 89, 97 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024299" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "leukemia" ], "offsets": [ [ 101, 109 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023418" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s1-t9", "type": "umlsterm", "text": [ "herpes simplex" ], "offsets": [ [ 5, 19 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019348" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s1-t10", "type": "umlsterm", "text": [ "herpes zoster" ], "offsets": [ [ 24, 37 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019360" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s1-t11", "type": "umlsterm", "text": [ "malignant lymphoma" ], "offsets": [ [ 79, 97 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024299" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 225, 232 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "lymphoma" ], "offsets": [ [ 278, 286 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024299" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "skin" ], "offsets": [ [ 306, 310 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "herpes" ], "offsets": [ [ 351, 357 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019369" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "simplex" ], "offsets": [ [ 358, 365 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0142328" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "non-Hodgkin lymphoma" ], "offsets": [ [ 266, 286 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024305" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s3-t7", "type": "umlsterm", "text": [ "herpes simplex" ], "offsets": [ [ 351, 365 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019348" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 384, 391 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "aciclovir" ], "offsets": [ [ 397, 406 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001367" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "plaques" ], "offsets": [ [ 421, 428 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011389" }, { "db_name": "UMLS", "db_id": "C0333463" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "scars" ], "offsets": [ [ 467, 472 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008767" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "Histologic" ], "offsets": [ [ 475, 485 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0205462" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "immunoglobulin" ], "offsets": [ [ 547, 561 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021027" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "light" ], "offsets": [ [ 562, 567 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023693" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "immunoglobulin light chain" ], "offsets": [ [ 547, 573 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021038" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "chemotherapeutical" ], "offsets": [ [ 630, 648 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032636" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 677, 684 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "patient died" ], "offsets": [ [ 677, 689 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011065" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "blast crisis" ], "offsets": [ [ 718, 730 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005699" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "occurrence" ], "offsets": [ [ 737, 747 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243132" } ] }, { "id": "DerHautarzt.00510256.eng.abstr-s7-t2", "type": "umlsterm", "text": [ "skin" ], "offsets": [ [ 770, 774 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] } ]

[]

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DerHautarzt.00510264.eng.abstr

[ { "id": "DerHautarzt.00510264.eng.abstr-passage-0", "type": "abstract", "text": [ "We report a woman with erythema palmare hereditarium , an anomaly not documented so far in the German literature . It is characterized by a bright erythema of the palms , usually persistent since birth . It is transmitted in an autosomal-recessive mode and has a benign course . In our patient it was possible to trace the palmar erythema over three generations ." ], "offsets": [ [ 0, 363 ] ] } ]

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[]

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DerHautarzt.00510266.eng.abstr

[ { "id": "DerHautarzt.00510266.eng.abstr-passage-0", "type": "abstract", "text": [ "We report on a child with pili trianguli et canaliculi . This hair shaft abnormality belongs to a heterogeneous group of diseases which are included under the synonym uncombable hair . The diagnosis was confirmed by scanning electron microscopy , revealing hair shafts with a characteristic longitudinal groove . In addition the girl suffered from atopic eczema and tooth anomalies . Our findings suggest that this disorder could represent a tricho-odontal subtype of ectodermal dysplasia ." ], "offsets": [ [ 0, 490 ] ] } ]

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[]

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"DerHautarzt.00510266.eng.abstr-s5-t1", "normalized": [] } ]

DerHautarzt.00510270.eng.abstr

[ { "id": "DerHautarzt.00510270.eng.abstr-passage-0", "type": "abstract", "text": [ "Annular erythema has been recognised as a cutaneous manifestation of Sjoegren's syndrome in the Asian literature and has been assumed to represent a distinct clinical entity . Since there are common pathophysiologic mechanisms , mainly the presence of anti-Ro/SSA or anti-La/SSB antibodies , it is difficult to separate the annular erythema from subacute cutaneous lupus erythematosus . Histological examination may reveal dermal mucin deposition resembling lupus erythematosus tumidus . We present a Chinese patient with widespread annular erythema , keratoconjunctivitis sicca , and anti-Ro/SSA antibodies . Clinical , histopathological , and immunogenetic findings are discussed reviewing the current literature , and the differences between annular erythema associated with Sjoegren's syndrome and cutaneous lupus erythematosus are emphasized ." ], "offsets": [ [ 0, 848 ] ] } ]

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[]

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DerHautarzt.00510299.eng.abstr

[ { "id": "DerHautarzt.00510299.eng.abstr-passage-0", "type": "abstract", "text": [ "With the help of the German Ministry of Health and the health insurance companies a national interdisciplinary project for children and adolescents with atopic eczema will be developed . The aim of the project is to generate standardized teaching concepts for parents and children covering medical , psychological and social aspect of the disease . 800 children and adolescents of different age groups will be enrolled in this poject . Furthermore , during the three years of the study the efficacy of the teaching concept will be evaluated ." ], "offsets": [ [ 0, 542 ] ] } ]

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[]

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DerHautarzt.00510302.eng.abstr

[ { "id": "DerHautarzt.00510302.eng.abstr-passage-0", "type": "abstract", "text": [ "Although the etiology of urticaria is mostly unclear , there are a number of recent new insights into the underlying pathomechanisms and causes . Dermal mast cell numbers and endothelial cell adhesion molecule and cytokine expression are also increased in uninvolved skin , while serum P-selectin levels are elevated , suggesting a systemic activation of the cutaneous inflammatory system in urticaria . In all adults , but not children with indolent mastocytosis , we found activating point mutations of c-kit , the mast cell growth factor receptor , in lesional cutaneous mast cells . In acute urticaria , IgE-dependent mechanisms are only rarely involved ( 0.9% ) , in contrast to generally held beliefs , whereas acute upper respiratory infections ( 39.3% ) and drug intolerance ( 9.2% ) are more frequent . In chronic urticaria , pseudoallergies to food ( 73% ) and more rarely chronic inflammatory gastrointestinal diseases ( 11% ) play a major role , with avoidance or elimination of the eliciting factors leading to long term remission . On the basis of recent findings , autoantibodies must be viewed mostly as secondary rather than causative in chronic urticaria ." ], "offsets": [ [ 0, 1174 ] ] } ]

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], "offsets": [ [ 392, 401 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042109" } ] }, { "id": "DerHautarzt.00510302.eng.abstr-s2-t9", "type": "umlsterm", "text": [ "mast cell" ], "offsets": [ [ 153, 162 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024880" } ] }, { "id": "DerHautarzt.00510302.eng.abstr-s2-t10", "type": "umlsterm", "text": [ "cell adhesion" ], "offsets": [ [ 187, 200 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007577" } ] }, { "id": "DerHautarzt.00510302.eng.abstr-s2-t11", "type": "umlsterm", "text": [ "adhesion molecule" ], "offsets": [ [ 192, 209 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007578" } ] }, { "id": "DerHautarzt.00510302.eng.abstr-s2-t12", "type": "umlsterm", "text": [ "cell adhesion molecule" ], "offsets": [ [ 187, 209 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007578" } ] }, { "id": "DerHautarzt.00510302.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "adults" ], "offsets": [ [ 411, 417 ] ], "normalized": 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[]

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DerHautarzt.00510309.eng.abstr

[ { "id": "DerHautarzt.00510309.eng.abstr-passage-0", "type": "abstract", "text": [ "Pemphigus diseases comprise a group of autoimmune disorders which are characterized by intraepidermal blisters and autoantibodies to components of desmosomes . Desmosomes mediate adhesion between neighbouring keratinocytes . A common feature of pemphigus diseases are intercellular deposits of IgG or , less frequently , of IgA within the epidermis . The group of pemphigus diseases includes pemphigus vulgaris , pemphigus foliaceus , pemphigus vegetans , pemphigus herpetiformis , pemphigus erythematosus , paraneoplastic pemphigus , drug-induced pemphigus , and IgA pemphigus . Using molecular tools , some of the autoantigens in these diseases have been characterized . In pemphigus vulgaris , autoantibodies are directed to desmoglein 3 and in pemphigus foliaceus to desmoglein 1. Target antigens in IgA pemphigus are desmocollin 1 and desmoglein 3. In paraneoplastic pemphigus , autoantibodies react with a complex of various proteins , including desmoplakin 1 and 2 , BP230, envoplakin , periplakin , plectin , desmoglein 3 , and a yet uncharacterized 170 kD protein . This review summarizes new insights into the immunopathogenesis and diagnosis of pemphigus diseases ." ], "offsets": [ [ 0, 1176 ] ] } ]

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"text": [ "desmosomes" ], "offsets": [ [ 147, 157 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011703" } ] }, { "id": "DerHautarzt.00510309.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "autoimmune disorders" ], "offsets": [ [ 39, 59 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004364" } ] }, { "id": "DerHautarzt.00510309.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "Desmosomes" ], "offsets": [ [ 160, 170 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011703" } ] }, { "id": "DerHautarzt.00510309.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "adhesion" ], "offsets": [ [ 179, 187 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001511" } ] }, { "id": "DerHautarzt.00510309.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "keratinocytes" ], "offsets": [ [ 209, 222 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022567" } ] }, { "id": "DerHautarzt.00510309.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "pemphigus" ], "offsets": [ [ 245, 254 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030807" } ] }, { "id": "DerHautarzt.00510309.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "diseases" ], "offsets": [ [ 255, 263 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510309.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "IgG" ], "offsets": [ [ 294, 297 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020852" } ] }, { "id": "DerHautarzt.00510309.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "IgA" ], "offsets": [ [ 324, 327 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020835" } ] }, { "id": "DerHautarzt.00510309.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "epidermis" ], "offsets": [ [ 339, 348 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014520" } ] }, { "id": "DerHautarzt.00510309.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "pemphigus" ], "offsets": [ [ 364, 373 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030807" } ] }, { "id": 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[]

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"normalized": [] }, { "id": "DerHautarzt.00510309.eng.abstr-s7-r2-t4.1-t1.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510309.eng.abstr-s7-t4", "arg2_id": "DerHautarzt.00510309.eng.abstr-s7-t1", "normalized": [] }, { "id": "DerHautarzt.00510309.eng.abstr-s7-r3-t2.2-t1.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510309.eng.abstr-s7-t2", "arg2_id": "DerHautarzt.00510309.eng.abstr-s7-t1", "normalized": [] }, { "id": "DerHautarzt.00510309.eng.abstr-s7-r4-t1.1-t4.1", "type": "associated_with", "arg1_id": "DerHautarzt.00510309.eng.abstr-s7-t1", "arg2_id": "DerHautarzt.00510309.eng.abstr-s7-t4", "normalized": [] } ]

DerHautarzt.00510319.eng.abstr

[ { "id": "DerHautarzt.00510319.eng.abstr-passage-0", "type": "abstract", "text": [ "Background and Objective . For rational therapeutic recommendations the spectrum and resistance of bacteria in skin diseases were investigated ." ], "offsets": [ [ 0, 144 ] ] } ]

[ { "id": "DerHautarzt.00510319.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Objective" ], "offsets": [ [ 15, 24 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018017" } ] }, { "id": "DerHautarzt.00510319.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "therapeutic" ], "offsets": [ [ 40, 51 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "DerHautarzt.00510319.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "recommendations" ], "offsets": [ [ 52, 67 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034866" } ] }, { "id": "DerHautarzt.00510319.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "bacteria" ], "offsets": [ [ 99, 107 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004611" }, { "db_name": "UMLS", "db_id": "C0521009" } ] }, { "id": "DerHautarzt.00510319.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "skin" ], "offsets": [ [ 111, 115 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] }, { "id": "DerHautarzt.00510319.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "diseases" ], "offsets": [ [ 116, 124 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510319.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "skin diseases" ], "offsets": [ [ 111, 124 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037274" } ] } ]

[]

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DerHautarzt.00510332.eng.abstr

[ { "id": "DerHautarzt.00510332.eng.abstr-passage-0", "type": "abstract", "text": [ "The most common cause of acral cyanosis is vascular spasm which can be induced by several drugs . An 87-year-old woman developed red and livid skin lesions on the fingers of both hands and several toes one month after beginning treatment with quinine sulfate 200 mg daily . The skin lesions progressed to necrosis in some areas ." ], "offsets": [ [ 0, 329 ] ] } ]

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[]

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"normalized": [] } ]

DerHautarzt.00510336.eng.abstr

[ { "id": "DerHautarzt.00510336.eng.abstr-passage-0", "type": "abstract", "text": [ "The Stewart-Bluefarb syndrome is defined as an unilateral angiodermatitis due to multiple arterio-venous fistules accompanied by acroangiodermatitis resembling Kaposi sarcoma ( pseudo-kaposi sarcoma ) . The acroangiodermatitis is most common on the lower limb . It leads to ulcerated nodules with a high risk of bleeding and infection , as well as edema , pain and seldom limb hypertrophy . Curative therapy requires elimination of the arteriovenous shunts . Surgical destruction of the multiple small fistulae is a limitating factor . A better alternative is embolisation , but this approach carries the risk of ischemia and necrosis . A 32 year old female patient with Stewart-Bluefarb syndrome is presented ; she has been successfully treated with embolisation on eight occasions ." ], "offsets": [ [ 0, 784 ] ] } ]

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[]

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DerHautarzt.00510345.eng.abstr

[ { "id": "DerHautarzt.00510345.eng.abstr-passage-0", "type": "abstract", "text": [ "A 60-years old female patient developed juxta-articular fibroid nodules and erythrocyanotic lesions of acrodermatitis chronica atrophicans after several tick bites . The woman was treated with ceftriaxon ( Rocephin ) 2 g daily parenterally without adverse reactions ." ], "offsets": [ [ 0, 267 ] ] } ]

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[]

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DerHautarzt.00510349.eng.abstr

[ { "id": "DerHautarzt.00510349.eng.abstr-passage-0", "type": "abstract", "text": [ "Atypical mycobacterial infections of the skin present a diagnostic and therapeutic challenge to dermatologists in many instances . We report on a patient who was diagnosed with atypical mycobacteriosis in its rarer , sporotrichoid form . Possible differential diagnoses are discussed . Efficient therapy using minocycline is demonstrated ." ], "offsets": [ [ 0, 339 ] ] } ]

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[]

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DerHautarzt.00510387.eng.abstr

[ { "id": "DerHautarzt.00510387.eng.abstr-passage-0", "type": "abstract", "text": [ "Dermatitis herpetiformis is associated with celiac disease . IgA antibodies to endomysium are considered as sensitive and specific markers for celiac disease . Recently , tissue transglutaminase was identified as the antigen of anti-endomysium antibodies . Moreover , serum levels of IgA antibodies to tissue transglutaminase were found to correlate with titers of IgA antibodies to endomysium in patients with both celiac disease and dermatitis herpetiformis . These findings confirm the close pathogenic relation between the two diseases . The determination of serum levels of antibodies to tissue transglutaminase may be a tool that can be routinely used for the diagnosis of dermatitis herpetiformis in the future ." ], "offsets": [ [ 0, 719 ] ] } ]

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"markers" ], "offsets": [ [ 131, 138 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005516" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 150, 157 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "celiac disease" ], "offsets": [ [ 143, 157 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007570" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "tissue" ], "offsets": [ [ 171, 177 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040300" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "transglutaminase" ], "offsets": [ [ 178, 194 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033679" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "antigen" ], "offsets": [ [ 217, 224 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003320" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "antibodies" ], "offsets": [ [ 244, 254 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003241" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "IgA" ], "offsets": [ [ 284, 287 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020835" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "antibodies" ], "offsets": [ [ 288, 298 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003241" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "tissue" ], "offsets": [ [ 302, 308 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040300" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "transglutaminase" ], "offsets": [ [ 309, 325 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033679" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "IgA" ], "offsets": [ [ 365, 368 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020835" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s4-t6", "type": "umlsterm", "text": [ "antibodies" ], "offsets": [ [ 369, 379 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003241" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s4-t7", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 397, 405 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s4-t8", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 423, 430 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s4-t9", "type": "umlsterm", "text": [ "dermatitis" ], "offsets": [ [ 435, 445 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011603" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s4-t10", "type": "umlsterm", "text": [ "celiac disease" ], "offsets": [ [ 416, 430 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007570" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "findings" ], "offsets": [ [ 468, 476 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243095" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "diseases" ], "offsets": [ [ 531, 539 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "determination" ], "offsets": [ [ 546, 559 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002778" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "antibodies" ], "offsets": [ [ 579, 589 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003241" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "tissue" ], "offsets": [ [ 593, 599 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040300" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "transglutaminase" ], "offsets": [ [ 600, 616 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033679" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s6-t5", "type": "umlsterm", "text": [ "diagnosis" ], "offsets": [ [ 666, 675 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011900" }, { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s6-t6", "type": "umlsterm", "text": [ "dermatitis" ], "offsets": [ [ 679, 689 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011603" } ] }, { "id": "DerHautarzt.00510387.eng.abstr-s6-t7", "type": "umlsterm", "text": [ "future" ], "offsets": [ [ 711, 717 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016884" } ] } ]

[]

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