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DerHautarzt.50460346.eng.abstr
|
DerHautarzt.50460346.eng.abstr
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"id": "DerHautarzt.50460346.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Linear focal elastosis is the term used to denote asymptomatic , palpable , striae-like lines extending horizontally across the middle and lower back . Histologically these lesions present a focal increase in elastic fibres separating the dermal collagen bundles . To date , this disorder has been described only in male patients , with onset after 60 years of age . A case of linear focal elastosis in a young female patient is presented . In the differential diagnosis the clinical variants of connective tissue naevi , of the elastolyses , and of actinic elastosis are discussed . Considering that this disorder may be merely an unusual form of striae distensae with a distinctive process of \" elastotic \" regeneration , the term elastotic striae seems appropriate ."
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[] |
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] |
DerHautarzt.50460349.eng.abstr
|
DerHautarzt.50460349.eng.abstr
|
[
{
"id": "DerHautarzt.50460349.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report on a 29-year-old female patient with an unusual pigmented lesion of the face . Clinically the lesion looked like a pigment patch of the naevus spilus type , while histological examination revealed the presence of dermal melanocytosis and multiple common blue naevi with a discrete lentiginous component in addition . The melanocytic nature of the infiltrate was ascertained by immunohistochemistry analysis using S 100 protein and HMB 45 antibodies . We interpret this lesion as agminated blue naevi in association with lentigo simplex , an unusual variant of speckled lentiginous naevus ."
],
"offsets": [
[
0,
599
]
]
}
] |
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] |
[] |
[] |
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] |
DerHautarzt.50460355.eng.abstr
|
DerHautarzt.50460355.eng.abstr
|
[
{
"id": "DerHautarzt.50460355.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Since the first dermatological outpatient clinic was started in Dresden in 1869 , it has seen the practice of dermatology in the broadest sense , with scientific research activity and innovation . The good working relationship between the dermatologists in private practice and those in the clinics has been the main factor in this successful development . The traditional background of the following sectors is highlighted : outpatient clinic , X-ray and UV ligth treatment , allergology and occupational dermatology , psychosomatic dermatology , dermatosurgery , and phlebology ."
],
"offsets": [
[
0,
581
]
]
}
] |
[
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{
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{
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"id": "DerHautarzt.50460355.eng.abstr-s3-t4",
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] |
[] |
[] |
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DerHautarzt.50460383.eng.abstr
|
DerHautarzt.50460383.eng.abstr
|
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"id": "DerHautarzt.50460383.eng.abstr-passage-0",
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"The concept of tuberculid was introduced by Darier in 1896. In contrast to \" true \" cutaneous tuberculosis , properties of the tuberculids were explained by an hyperergic response to myobacteria or their fragments released from a different site of manifest or passed tuberculous infection . Key features include a strongly positive tuberculin skin test , evidence of concomitant manifest or past tuberculosis , and prompt response to antituberculous therapy The inability to culture M. tuberculosis or to demonstrate it microscopically from lesional biopsies , together with reports on tuberculid-like eruptions after BCG vaccination , supports this concept . Clinical manifestations are lichen scrophulosorum , papulo-necrotic tuberculids and erythema induratum of Bazin . The existence of tuberculids has been questioned , however , because the clinical and histological appearances are not always specific . An increasing number of case reports on tuberculids , new immunological tests and molecular biology-based techniques for the detection of mycobacteria have shed new light on the tuberculid concept ."
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] |
DerHautarzt.50460394.eng.abstr
|
DerHautarzt.50460394.eng.abstr
|
[
{
"id": "DerHautarzt.50460394.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Exposure of the skin to ultraviolet irradiation is an important risk factor for the development of malignant melanoma , with UVA possibly playing an important role . Hereditary factors are also relevant . In the dysplastic nevus syndrome a genetic instability has been shown by different methods . In xeroderma pigmentosum the DNA repair defect is thought to be responsible for the high incidence of malignant melanoma . Frequent and non-random changes in certain chromosomes have been demonstrated in melanoma cells . These might contain sequences that control melanoma growth or melanoma suppressor genes . Especially the short arm of chromosome 9 is thought to contain one of these genes . This hypothesis is supported by a genetic linkage analysis in melanoma families and the demonstration of a germ line deletion of the locus 9p21 in a patient with eight primary melanomas . Changes in known tumor suppressor genes and oncogenes have also been reported in melanoma , but no consistent sequence of genetic events is known ."
],
"offsets": [
[
0,
1028
]
]
}
] |
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"risk"
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{
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{
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DerHautarzt.50460406.eng.abstr
|
DerHautarzt.50460406.eng.abstr
|
[
{
"id": "DerHautarzt.50460406.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The appearance of severe ulceration of the skin in patients with rheumatoid arthritis is often associated with a tendency to progression of the underlying disease , involvement of internal organs and increased mortality . In the pathogenesis of such ulceration there are multiple causes for their development , persistence and tendency to poor healing . They include localized or generalized immune complex vasculitis , treatment with anti-inflammatory drugs and their side effects following the treatment , arterial and venous insufficiency , and mechanical factors . The management of severe ulceration requires stabilization of the underlying autoimmune disease , e.g. with high doses of glucocorticosteroids or other immunosuppressive drugs or plasmapheresis . Adjuvant treatment of pain with analgesics , improvement of blood perfusion and anti-inflammatory drugs should accompany the topical therapy of ulcers . After suppression of the local inflammatory reaction surgical intervention becomes necessary in most of the patients , and vascularized muscle flaps should be used in preference to meshgrafts or split skin grafts for extensive ulceration in rheumatoid arthritis . A hopeful perspective in the treatment of severe rheumatoid arthritis might be opened up with immunotherapy using monoclonal antibodies ."
],
"offsets": [
[
0,
1319
]
]
}
] |
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],
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]
],
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DerHautarzt.50460413.eng.abstr
|
DerHautarzt.50460413.eng.abstr
|
[
{
"id": "DerHautarzt.50460413.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The clinical and histological diagnosis of sclerotic fibroma is important because of its potential association with Cowden's syndrome . Despite its distinctive histological appearance the lesion is often misdiagnosed . We therefore present five of our own cases ( 2F , 3M ) in which the tumor was located on the head ( n=2), arm ( n=2) and leg ( n=1), respectively . Clinically , the lesions were white to flesh-colored firm nodules ranging in size from 0.5 to 1.2 cm . None of our patients revealed any clinical evidence of Cowden's disease . Simple surgical excision seems to be curative . Histologically , they were well-circumscribed but not encapsulated dermal nodules composed of storiform-arranged sclerosing collagen bundles and vimentin-positive fibroblastlike cells interspersed in three cases by a number of -smooth-muscle actin-positive myofibroblasts . Approximately 50% of cells ( dermal dendritic cells ( DD ) ) also reacted for factor XIIIa evenly scattered throughout the lesion in contrast to the very few ( 5% ) CD34+ DD found predominantly at the lower border , thus possibly reflecting the distribution of these cells in normal skin . Sclerotic fibroma expands the spectrum of fibrous lesions that may express -smooth-muscle actin ."
],
"offsets": [
[
0,
1253
]
]
}
] |
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"id": "DerHautarzt.50460413.eng.abstr-s3-t2",
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"head"
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"arm"
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{
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"db_id": "C0023216"
}
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},
{
"id": "DerHautarzt.50460413.eng.abstr-s4-t1",
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"white"
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"patients"
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"id": "DerHautarzt.50460413.eng.abstr-s6-t1",
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},
{
"id": "DerHautarzt.50460413.eng.abstr-s7-t1",
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"text": [
"collagen"
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},
{
"id": "DerHautarzt.50460413.eng.abstr-s7-t2",
"type": "umlsterm",
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"vimentin-positive"
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},
{
"id": "DerHautarzt.50460413.eng.abstr-s7-t3",
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"cells"
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},
{
"id": "DerHautarzt.50460413.eng.abstr-s7-t4",
"type": "umlsterm",
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"actin-positive"
],
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{
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{
"id": "DerHautarzt.50460413.eng.abstr-s8-t6",
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"id": "DerHautarzt.50460413.eng.abstr-s8-t7",
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"dendritic cells"
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{
"id": "DerHautarzt.50460413.eng.abstr-s8-t8",
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]
}
] |
[] |
[] |
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DerHautarzt.50460417.eng.abstr
|
DerHautarzt.50460417.eng.abstr
|
[
{
"id": "DerHautarzt.50460417.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The draining sinus is an unpleasant complication of acne conglobata , acne fulminans , acne inversa , rosacea conglobata and rosacea fulminans ( pyoderma faciale ) . It is most common on the face , especially in the nasolabial folds , and on the neck below the mandibular line . Clinically , it is an elongated ( 2-5 cm long ) , elevated , periodically inflamed lesion , which sporadically discharges pus . The lesion persists with no tendency to spontaneous regression . Histopathologically , it consists of elaborate , epithelialized galleries connected to the skin surface at multiple points . It contains corneocytes , hairs , bacteria , serum , inflammatory cells and epitheloid granulomas . A surgical thread placed into the skin provides a model in which the generation of sinus tracts can be studied . Therapy is difficult . Intralesional corticosteroid injection , cryosurgery and isotretinoin are not always very effective . Sometimes complete excision of the lesion is necessary . The draining sinus is a special form of scar analogous to the pilonidal cyst ."
],
"offsets": [
[
0,
1070
]
]
}
] |
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{
"id": "DerHautarzt.50460417.eng.abstr-s1-t2",
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"id": "DerHautarzt.50460417.eng.abstr-s1-t3",
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"acne"
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"rosacea"
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{
"id": "DerHautarzt.50460417.eng.abstr-s2-t1",
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{
"id": "DerHautarzt.50460417.eng.abstr-s2-t2",
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},
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"id": "DerHautarzt.50460417.eng.abstr-s2-t3",
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"line"
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"id": "DerHautarzt.50460417.eng.abstr-s3-t1",
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"discharges"
],
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],
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},
{
"id": "DerHautarzt.50460417.eng.abstr-s3-t2",
"type": "umlsterm",
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},
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"id": "DerHautarzt.50460417.eng.abstr-s4-t1",
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{
"id": "DerHautarzt.50460417.eng.abstr-s5-t1",
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"skin"
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},
{
"id": "DerHautarzt.50460417.eng.abstr-s6-t1",
"type": "umlsterm",
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},
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"id": "DerHautarzt.50460417.eng.abstr-s6-t2",
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"id": "DerHautarzt.50460417.eng.abstr-s6-t3",
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] |
[] |
[] |
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}
] |
DerHautarzt.50460421.eng.abstr
|
DerHautarzt.50460421.eng.abstr
|
[
{
"id": "DerHautarzt.50460421.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 38-year-old male patient presented with circumscribed scleroderma ( 10x12 cm ) in the left pectoral area . Hyperaemia of the skin in the area of the lilac ring ( morphoea ) was quantified by means of Laser-Doppler flux ( LDF ) . At the lilac border of the morphoea LDF was increased to 420% of the reference value recorded for the unaffected skin of the contralateral side . Immediately after 13 days of antibiotic therapy ( 3x10 Mega penicillin G per day , i.v. ) LDF normalized , though clinical changes were hardly apparent at this stage . By 6 months later , LDF was still in the normal range , and clinical signs , such as induration and hyperaemic redness , had also significantly improved . LDF measurements allow assessment of the therapeutic response to antibiotic therapy at a very early stage while the clinical situation is still unchanged ."
],
"offsets": [
[
0,
855
]
]
}
] |
[
{
"id": "DerHautarzt.50460421.eng.abstr-s1-t1",
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"text": [
"male"
],
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[
14,
18
]
],
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{
"db_name": "UMLS",
"db_id": "C0024554"
},
{
"db_name": "UMLS",
"db_id": "C0086582"
}
]
},
{
"id": "DerHautarzt.50460421.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"patient"
],
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[
19,
26
]
],
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{
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"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.50460421.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"scleroderma"
],
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[
56,
67
]
],
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{
"db_name": "UMLS",
"db_id": "C0011644"
},
{
"db_name": "UMLS",
"db_id": "C0036421"
}
]
},
{
"id": "DerHautarzt.50460421.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"circumscribed scleroderma"
],
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[
42,
67
]
],
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{
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"db_id": "C0036420"
}
]
},
{
"id": "DerHautarzt.50460421.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"Hyperaemia"
],
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[
109,
119
]
],
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{
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"db_id": "C0041834"
},
{
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"db_id": "C0020452"
}
]
},
{
"id": "DerHautarzt.50460421.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"skin"
],
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[
127,
131
]
],
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{
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"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.50460421.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"morphoea"
],
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[
164,
172
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0036420"
}
]
},
{
"id": "DerHautarzt.50460421.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"morphoea"
],
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[
258,
266
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0036420"
}
]
},
{
"id": "DerHautarzt.50460421.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"value"
],
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[
310,
315
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0042295"
}
]
},
{
"id": "DerHautarzt.50460421.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"skin"
],
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[
344,
348
]
],
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{
"db_name": "UMLS",
"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.50460421.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"reference value"
],
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[
300,
315
]
],
"normalized": [
{
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"db_id": "C0034926"
}
]
},
{
"id": "DerHautarzt.50460421.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"antibiotic"
],
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[
406,
416
]
],
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"db_id": "C0003232"
}
]
},
{
"id": "DerHautarzt.50460421.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"therapy"
],
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[
417,
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]
],
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"db_id": "C0087111"
},
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}
]
},
{
"id": "DerHautarzt.50460421.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"penicillin"
],
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437,
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]
],
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{
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"db_id": "C0030842"
},
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"db_id": "C0220892"
}
]
},
{
"id": "DerHautarzt.50460421.eng.abstr-s4-t4",
"type": "umlsterm",
"text": [
"stage"
],
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537,
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]
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}
]
},
{
"id": "DerHautarzt.50460421.eng.abstr-s4-t5",
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"text": [
"penicillin G"
],
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],
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}
]
},
{
"id": "DerHautarzt.50460421.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"signs"
],
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]
],
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}
]
},
{
"id": "DerHautarzt.50460421.eng.abstr-s5-t2",
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],
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}
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},
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"id": "DerHautarzt.50460421.eng.abstr-s6-t1",
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}
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},
{
"id": "DerHautarzt.50460421.eng.abstr-s6-t3",
"type": "umlsterm",
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}
]
},
{
"id": "DerHautarzt.50460421.eng.abstr-s6-t4",
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"id": "DerHautarzt.50460421.eng.abstr-s6-t6",
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],
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}
]
}
] |
[] |
[] |
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DerHautarzt.50460425.eng.abstr
|
DerHautarzt.50460425.eng.abstr
|
[
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"Idiopathic middermal elastolysis ( IMDE ) is a rare disorder with two different clinical presentations : type I lesions , with tiny wrinkles along skin cleavage lines in large confluent areas , and type II lesions , with small perifollicular papular protrusions . The histopathological picture is characteristic . IMDE is mainly seen in healthy young or middle-aged women . We describe a 60-year-old male patient with this disorder . The special interest of this case report is that there was no photosensitivity and no exacerbation with PUV therapy . IMDE is probably a special sort of elastolytic disorder , for which immunologic mechanisms seem possible ."
],
"offsets": [
[
0,
658
]
]
}
] |
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] |
[] |
[] |
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] |
DerHautarzt.50460429.eng.abstr
|
DerHautarzt.50460429.eng.abstr
|
[
{
"id": "DerHautarzt.50460429.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Pachydermoperiostosis ( Friedreich-Erb-Arnold syndrome , Touraine-Solente-Golé syndrome ) is a rare disease with an autosomal dominant mode of unheritance ; it occurs almost exclusively in men . A report of typical pachydermoperiostosis in a 31-year-old man is presented . Associated features were clubbed digits of the hands and feet with watch-crystal nails , thickening of the skin and soft tissues , hyperhidrosis of hands and feet , hyperplasia of the sebaceous glands with seborrhoea , gynaecomastia , and ophthalmic abnormalities that had been present since puberty . Radiological examination revealed periosteal hyperostosis of the short and long bones . Endocrine disturbances were not detected . Skin biopsies showed hypertrophy of the skin and skin appendages . Primary ( idiopathic , hereditary ) pachydermoperiostosis should be distinguished from secondary ( symptomatic ) forms of the disease , which are often associated with lung tumours ."
],
"offsets": [
[
0,
955
]
]
}
] |
[
{
"id": "DerHautarzt.50460429.eng.abstr-s1-t1",
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"Pachydermoperiostosis"
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0,
21
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"db_id": "C0029411"
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},
{
"id": "DerHautarzt.50460429.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"syndrome"
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54
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"db_id": "C0039082"
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},
{
"id": "DerHautarzt.50460429.eng.abstr-s1-t3",
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"text": [
"syndrome"
],
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79,
87
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]
},
{
"id": "DerHautarzt.50460429.eng.abstr-s1-t4",
"type": "umlsterm",
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"disease"
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"db_id": "C0012634"
}
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},
{
"id": "DerHautarzt.50460429.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"men"
],
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}
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},
{
"id": "DerHautarzt.50460429.eng.abstr-s2-t1",
"type": "umlsterm",
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"man"
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257
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}
]
},
{
"id": "DerHautarzt.50460429.eng.abstr-s3-t1",
"type": "umlsterm",
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"hands"
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325
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],
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"db_id": "C0018563"
}
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},
{
"id": "DerHautarzt.50460429.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"feet"
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],
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"db_id": "C0016504"
}
]
},
{
"id": "DerHautarzt.50460429.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"nails"
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354,
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]
],
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}
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},
{
"id": "DerHautarzt.50460429.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"skin"
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},
{
"id": "DerHautarzt.50460429.eng.abstr-s3-t5",
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},
{
"id": "DerHautarzt.50460429.eng.abstr-s3-t6",
"type": "umlsterm",
"text": [
"hyperhidrosis"
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},
{
"id": "DerHautarzt.50460429.eng.abstr-s3-t7",
"type": "umlsterm",
"text": [
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],
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},
{
"id": "DerHautarzt.50460429.eng.abstr-s3-t8",
"type": "umlsterm",
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"hands"
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}
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},
{
"id": "DerHautarzt.50460429.eng.abstr-s3-t9",
"type": "umlsterm",
"text": [
"feet"
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}
]
},
{
"id": "DerHautarzt.50460429.eng.abstr-s3-t10",
"type": "umlsterm",
"text": [
"hyperplasia"
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438,
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},
{
"id": "DerHautarzt.50460429.eng.abstr-s3-t11",
"type": "umlsterm",
"text": [
"seborrhoea"
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},
{
"id": "DerHautarzt.50460429.eng.abstr-s3-t12",
"type": "umlsterm",
"text": [
"gynaecomastia"
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},
{
"id": "DerHautarzt.50460429.eng.abstr-s3-t13",
"type": "umlsterm",
"text": [
"abnormalities"
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},
{
"id": "DerHautarzt.50460429.eng.abstr-s3-t14",
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"text": [
"puberty"
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]
},
{
"id": "DerHautarzt.50460429.eng.abstr-s3-t15",
"type": "umlsterm",
"text": [
"sebaceous glands"
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473
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}
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},
{
"id": "DerHautarzt.50460429.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"hyperostosis"
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},
{
"id": "DerHautarzt.50460429.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"bones"
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{
"id": "DerHautarzt.50460429.eng.abstr-s5-t1",
"type": "umlsterm",
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"id": "DerHautarzt.50460429.eng.abstr-s6-t1",
"type": "umlsterm",
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"Skin"
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{
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"id": "DerHautarzt.50460429.eng.abstr-s6-t4",
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},
{
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},
{
"id": "DerHautarzt.50460429.eng.abstr-s7-t4",
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},
{
"id": "DerHautarzt.50460429.eng.abstr-s7-t5",
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"tumours"
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"db_id": "C0027651"
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]
}
] |
[] |
[] |
[
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{
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] |
DerHautarzt.50460451.eng.abstr
|
DerHautarzt.50460451.eng.abstr
|
[
{
"id": "DerHautarzt.50460451.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Atopic dermatitis and psoriasis vulgaris belong to the most common diseases in dermatology . Since these chronical diseases progress over years and decades , they may lead to restrictions in private and professional life as well as to psychological stress of concerned patients . Therefore a lasting , stabilising , stage-adjusted topical treatment is necessary . Main component of this treatment in a complete therapeutical concept consists in an adjuvant basic therapy with oil baths and with emollients containing urea or no drug additives at all . Thus the vehicle itself is therapeutically effective . Altered structure and function of the skin measured by increased transepidermal water loss , dysfunction of skin lipid barrier , augmented skin permeability and skin roughness can be improved . Due to this treatment clinical symptoms can be diminished and relapses can be avoided . Corticosteroids and other specific medications can be reduced by using basic therapeutics with little side effects . This means economical benefit as well . So far adjuvant basic treatment is an essential part in the therapy of chronic inflammatory skin diseases ."
],
"offsets": [
[
0,
1153
]
]
}
] |
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"id": "DerHautarzt.50460451.eng.abstr-s4-t5",
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}
] |
[] |
[] |
[
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] |
DerHautarzt.50460462.eng.abstr
|
DerHautarzt.50460462.eng.abstr
|
[
{
"id": "DerHautarzt.50460462.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Cryosurgery with liquid nitrogen led to total or partial success in 64% of 336 patients with keloids and in 82% of 58 persons with hypertrophic scars . In 11% and 3% of the patients , respectively , the results were disappointing . In 19% and 12% , patients broke off the painful and long-term therapy . Nonetheless , in view of the results of other therapeutic methods , we prefer cryosurgery ( either as monotherapy or combined with corticoids or conventional surgery ) for keloids . For hypertrophic scars , however , the therapy is restricted to exceptional cases since nearly all lesions regress spontaneously within a few years ."
],
"offsets": [
[
0,
635
]
]
}
] |
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DerHautarzt.50460477.eng.abstr
|
DerHautarzt.50460477.eng.abstr
|
[
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"text": [
"A case report is presented to illustrate the cutaneous manifestations in essential thrombocythaemia . Knowledge of the related skin lesions may lead to earlier detection of this myeloproliferative disorder . Treatment may prevent severe haemorrhagic or thrombotic complications . Erythromelalgia is causally related to thrombocythaemia ; prompt relief of painful symptoms after treatment with aspirin is typical ."
],
"offsets": [
[
0,
413
]
]
}
] |
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DerHautarzt.50460481.eng.abstr
|
DerHautarzt.50460481.eng.abstr
|
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{
"id": "DerHautarzt.50460481.eng.abstr-passage-0",
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"text": [
"An 85-year-old man presented with a firm , papillomatous nodule on the upper lip , which had been growing slowly for 30 years . Histopathologic examination revealed an apocrine mixed tumour with follicular differentiation . Mixed tumours of the skin are rare benign neoplasms , which are composed of different tissue components , e.g. epithelial and glandular elements and myxoid or chondroid components . Mixed tumours with apocrine differentiation can be discriminated from mixed tumours with eccrine differentiation . Criteria for apocrine differentiation are : decapitation secretion , elongated gland-like and duct-like structures lined with two rows of epithelial cells and branching of tubular structures . Follicular structures are another clue to the apocrine differentiation of neoplasms . The designation mixed tumour is preferable to chondroid syringoma , because most mixed tumours show apocrine differentiation . The differential diagnosis of apocrine mixed tumour includes fibroadenoma , hidradenoma , mucinous adenocarcinoma , adenoid cystic carcinoma , and rare soft tissue tumours like the myxoid chondrosarcoma ."
],
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DerHautarzt.50460485.eng.abstr
|
DerHautarzt.50460485.eng.abstr
|
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{
"id": "DerHautarzt.50460485.eng.abstr-passage-0",
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"text": [
"We report on a 2-year-old girl with chronic bullous disease of childhood ( CBDC ) . Concomitantly with a feverish gastrointestinal infection caused by Salmonella enteritidis , the child presented with lesions resembling impetigo contagiosa on the legs and face . Following antibiotic treatment with cephalosporins p.o. and flucloxacillin i.v. she developed typical symptoms of CBDC , i.e. tense blisters on erythematous skin in the perineal area , on the flexor aspects of the thighs and upper arms and on the face . Direct immunofluorescence revealed a linear IgA deposition along the basement membrane zone , confirming the diagnosis of CBDC . These lesions cleared rapidly after treatment with dapsone p.o. This case prompted us to consider new aspects of the pathogenesis , clinical entity and treatment of this rare bullous disease of childhood ."
],
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0,
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[] |
[] |
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] |
DerHautarzt.50460490.eng.abstr
|
DerHautarzt.50460490.eng.abstr
|
[
{
"id": "DerHautarzt.50460490.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Annular elastolytic giant cell granuloma is mostly found in middle aged women in skin areas exposed to sunlight . Our 17-year-old female patient had a widespread reddish-brown lesion on the abdomen that met the histological criteria for annular elastolytic giant cell granuloma . However , the clinical findings and the localization were uncommon . UV light was excluded as a trigger . Other , still unknown , factors that might change antigenicity of elastic fibres must be considered . Spontaneous resolution suggests a transient influence of such factors . Differential diagnosis includes skin disorders with elastolysis ; discrimination especially from mid-dermal elastolysis is not well defined ."
],
"offsets": [
[
0,
701
]
]
}
] |
[
{
"id": "DerHautarzt.50460490.eng.abstr-s1-t1",
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"text": [
"giant"
],
"offsets": [
[
20,
25
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0017547"
}
]
},
{
"id": "DerHautarzt.50460490.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"cell"
],
"offsets": [
[
26,
30
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0007634"
}
]
},
{
"id": "DerHautarzt.50460490.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"granuloma"
],
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[
31,
40
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018188"
}
]
},
{
"id": "DerHautarzt.50460490.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"women"
],
"offsets": [
[
72,
77
]
],
"normalized": [
{
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"db_id": "C0043210"
}
]
},
{
"id": "DerHautarzt.50460490.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"skin"
],
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[
81,
85
]
],
"normalized": [
{
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"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.50460490.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"sunlight"
],
"offsets": [
[
103,
111
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0038817"
}
]
},
{
"id": "DerHautarzt.50460490.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"giant cell"
],
"offsets": [
[
20,
30
]
],
"normalized": [
{
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"db_id": "C0017526"
}
]
},
{
"id": "DerHautarzt.50460490.eng.abstr-s1-t8",
"type": "umlsterm",
"text": [
"middle aged"
],
"offsets": [
[
60,
71
]
],
"normalized": [
{
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"db_id": "C0205847"
},
{
"db_name": "UMLS",
"db_id": "C0026062"
}
]
},
{
"id": "DerHautarzt.50460490.eng.abstr-s1-t9",
"type": "umlsterm",
"text": [
"giant cell granuloma"
],
"offsets": [
[
20,
40
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DerHautarzt.50460494.eng.abstr
|
DerHautarzt.50460494.eng.abstr
|
[
{
"id": "DerHautarzt.50460494.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 49-year-old man suffered from Hailey-Hailey disease for several years . The patient presented with an acute exacerbation of the disease , which did not respond to oral treatment with high doses of glucocorticosteroids . A skin biopsy was taken and the histological examination indicated a viral infection . Herpes simplex virus was confirmed by electron microscopy ( negative staining ) and polymerase chain reaction ( PCR ) . The PCR presents a sensitive and effective molecular-biological method for the diagnosis of viral infections ."
],
"offsets": [
[
0,
539
]
]
}
] |
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DerHautarzt.50460498.eng.abstr
|
DerHautarzt.50460498.eng.abstr
|
[
{
"id": "DerHautarzt.50460498.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report on a 34-year-old male patient who developed generalized parakeratosis variegata lesions 4 years after suffering from pityriasis lichenoides et varioliformis acuta . For further investigation of a possible interrelationship between these two diseases of the parapsoriasis group and their relationship to the T-cell type of cutaneous non-Hodgkin-lymphoma , histological , immunohistological and molecular-biological techniques were applied . We were able to demonstrate typical morphological features common to both diseases , and a polyclonal T-cell infiltrate in both . It is concluded that pityriasis lichenoides et varioliformis acuta and parakeratosis variegata are separate entities without monoclonal rearrangement or signs of malignancy ."
],
"offsets": [
[
0,
754
]
]
}
] |
[
{
"id": "DerHautarzt.50460498.eng.abstr-s1-t1",
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"male"
],
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31
]
],
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"db_id": "C0024554"
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"db_id": "C0086582"
}
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},
{
"id": "DerHautarzt.50460498.eng.abstr-s1-t2",
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"patient"
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39
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"db_id": "C0030705"
}
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},
{
"id": "DerHautarzt.50460498.eng.abstr-s1-t3",
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"text": [
"parakeratosis"
],
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66,
79
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}
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},
{
"id": "DerHautarzt.50460498.eng.abstr-s1-t4",
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"pityriasis"
],
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127,
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]
],
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}
]
},
{
"id": "DerHautarzt.50460498.eng.abstr-s1-t5",
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"text": [
"varioliformis"
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[
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166
]
],
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"db_id": "C0125606"
}
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},
{
"id": "DerHautarzt.50460498.eng.abstr-s1-t6",
"type": "umlsterm",
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"parakeratosis variegata"
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[
66,
89
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],
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"db_id": "C0030437"
}
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},
{
"id": "DerHautarzt.50460498.eng.abstr-s1-t7",
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"text": [
"pityriasis lichenoides"
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]
],
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},
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"id": "DerHautarzt.50460498.eng.abstr-s2-t1",
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}
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},
{
"id": "DerHautarzt.50460498.eng.abstr-s2-t2",
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"parapsoriasis"
],
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[
267,
280
]
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}
]
},
{
"id": "DerHautarzt.50460498.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"T-cell"
],
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[
317,
323
]
],
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}
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},
{
"id": "DerHautarzt.50460498.eng.abstr-s2-t4",
"type": "umlsterm",
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{
"id": "DerHautarzt.50460498.eng.abstr-s3-t3",
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{
"id": "DerHautarzt.50460498.eng.abstr-s4-t2",
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"id": "DerHautarzt.50460498.eng.abstr-s4-t5",
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"id": "DerHautarzt.50460498.eng.abstr-s4-t8",
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}
] |
[] |
[] |
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DerHautarzt.50460502.eng.abstr
|
DerHautarzt.50460502.eng.abstr
|
[
{
"id": "DerHautarzt.50460502.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 71-year-old woman suffered from pronounced erosion of her nose after soft X-ray therapy ( total dose 28 Gy , half dose depth 10.5-11.5 mm ) . 5 weeks after the end of the irradiation no healing tendency was observed . This unusual clinical course was caused by a simultaneously existing pemphigus vulgaris that worsened after radiotherapy , presumably as a consequence of the release of epidermal antigens . In this case it is improbable that the pemphigus was induced by the radiotherapy , as has been reported on several occasions in the literature . However , this possibility cannot be entirely excluded ."
],
"offsets": [
[
0,
611
]
]
}
] |
[
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{
"id": "DerHautarzt.50460502.eng.abstr-s1-t2",
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},
{
"id": "DerHautarzt.50460502.eng.abstr-s1-t3",
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"X-ray"
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}
]
},
{
"id": "DerHautarzt.50460502.eng.abstr-s1-t4",
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"therapy"
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{
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},
{
"id": "DerHautarzt.50460502.eng.abstr-s2-t1",
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"irradiation"
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173,
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},
{
"id": "DerHautarzt.50460502.eng.abstr-s3-t1",
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"id": "DerHautarzt.50460502.eng.abstr-s3-t2",
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]
},
{
"id": "DerHautarzt.50460502.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"release"
],
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[
378,
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},
{
"id": "DerHautarzt.50460502.eng.abstr-s3-t4",
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"antigens"
],
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399,
407
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"id": "DerHautarzt.50460502.eng.abstr-s3-t5",
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289,
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},
{
"id": "DerHautarzt.50460502.eng.abstr-s4-t1",
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449,
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},
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},
{
"id": "DerHautarzt.50460502.eng.abstr-s4-t3",
"type": "umlsterm",
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{
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"db_id": "C0023866"
}
]
}
] |
[] |
[] |
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},
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{
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{
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{
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}
] |
DerHautarzt.50460528.eng.abstr
|
DerHautarzt.50460528.eng.abstr
|
[
{
"id": "DerHautarzt.50460528.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In Europe and in the US ectoparasitic diseases are increasingly diagnosed in all classes of society . Modern means of transportation promote the spreading from endemic areas into new regions and therefore questions of therapy are becoming increasingly important . A series of preparations in various galenic formulations and in various concentrations are available to treat the ectoparasitic diseases . Due to reports on Lindane poisonings the clinical use of Lindane preparations for the treatment of scabies and pediculosis has become somewhat controversial . In this article we review older and more recent data on pharmacology , pharmacokinetics and toxicology of -1 , 2,3 , 4,5 , 6-Hexachlorcyclohexan [ Lindane ] . It is pointed out that in the USA Lindane is offered in 1% preparations whereas in the German speaking Europe only 0.3% preparations are available . This latter concentration is considered as sufficient to treat the ectoparasitosis . Furthermore the use of this remedy and aspects of Lindane resistance are discussed . It is concluded that only through additional in depth education of the patients and their folks successful treatment is possible and intoxication can be prevented ."
],
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[
0,
1204
]
]
}
] |
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] |
[] |
[] |
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{
"id": "DerHautarzt.50460528.eng.abstr-s4-r22-t1.1-t7.1",
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},
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{
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{
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}
] |
DerHautarzt.50460537.eng.abstr
|
DerHautarzt.50460537.eng.abstr
|
[
{
"id": "DerHautarzt.50460537.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Since 1993 almost 400 patients with port wine stains have been treated with the flashlamp pumped pulsed dye laser . The therapeutic effect on 61 adult patients was evaluated . After a mean of 2.16 treatments the colour lightened by between 33% and 100% in 70% of these patients . The best results were obtained in patients with plain pink port wine stains . In this kind of port wine stains the argon laser has proved to be far less successful . The rate of adverse effects amounted to only 5% . The results are expected to be improved by further laser sessions . The flashlamp pumped pulsed dye laser is an important advance in the treatment of port wine stains ."
],
"offsets": [
[
0,
664
]
]
}
] |
[
{
"id": "DerHautarzt.50460537.eng.abstr-s1-t1",
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"text": [
"patients"
],
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[
22,
30
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.50460537.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"wine"
],
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[
41,
45
]
],
"normalized": [
{
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"db_id": "C0043188"
}
]
},
{
"id": "DerHautarzt.50460537.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"stains"
],
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[
46,
52
]
],
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{
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"db_id": "C0038128"
},
{
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}
]
},
{
"id": "DerHautarzt.50460537.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"dye"
],
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[
104,
107
]
],
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{
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"db_id": "C0013343"
}
]
},
{
"id": "DerHautarzt.50460537.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"laser"
],
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108,
113
]
],
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]
},
{
"id": "DerHautarzt.50460537.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"port wine stains"
],
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[
36,
52
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],
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"db_id": "C0235752"
}
]
},
{
"id": "DerHautarzt.50460537.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"therapeutic"
],
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[
120,
131
]
],
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"db_id": "C0039796"
}
]
},
{
"id": "DerHautarzt.50460537.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"adult"
],
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[
145,
150
]
],
"normalized": [
{
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"db_id": "C0001675"
}
]
},
{
"id": "DerHautarzt.50460537.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"patients"
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[
151,
159
]
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{
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"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.50460537.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"treatments"
],
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[
197,
207
]
],
"normalized": [
{
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"db_id": "C0087111"
},
{
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}
]
},
{
"id": "DerHautarzt.50460537.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"colour"
],
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[
212,
218
]
],
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{
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"db_id": "C0009393"
}
]
},
{
"id": "DerHautarzt.50460537.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"patients"
],
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[
269,
277
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],
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"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.50460537.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"patients"
],
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314,
322
]
],
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}
]
},
{
"id": "DerHautarzt.50460537.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"wine"
],
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344,
348
]
],
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}
]
},
{
"id": "DerHautarzt.50460537.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"stains"
],
"offsets": [
[
349,
355
]
],
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"db_id": "C0038128"
},
{
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}
]
},
{
"id": "DerHautarzt.50460537.eng.abstr-s4-t4",
"type": "umlsterm",
"text": [
"port wine stains"
],
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[
339,
355
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],
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}
]
},
{
"id": "DerHautarzt.50460537.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"wine"
],
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]
},
{
"id": "DerHautarzt.50460537.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"stains"
],
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]
},
{
"id": "DerHautarzt.50460537.eng.abstr-s5-t3",
"type": "umlsterm",
"text": [
"argon"
],
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395,
400
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],
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"db_id": "C0003781"
}
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},
{
"id": "DerHautarzt.50460537.eng.abstr-s5-t4",
"type": "umlsterm",
"text": [
"laser"
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},
{
"id": "DerHautarzt.50460537.eng.abstr-s5-t5",
"type": "umlsterm",
"text": [
"port wine stains"
],
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374,
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}
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},
{
"id": "DerHautarzt.50460537.eng.abstr-s6-t1",
"type": "umlsterm",
"text": [
"adverse effects"
],
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[
458,
473
]
],
"normalized": [
{
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"db_id": "C0001688"
}
]
},
{
"id": "DerHautarzt.50460537.eng.abstr-s7-t1",
"type": "umlsterm",
"text": [
"laser"
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},
{
"id": "DerHautarzt.50460537.eng.abstr-s8-t1",
"type": "umlsterm",
"text": [
"dye"
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592,
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},
{
"id": "DerHautarzt.50460537.eng.abstr-s8-t2",
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{
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{
"id": "DerHautarzt.50460537.eng.abstr-s8-t4",
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{
"id": "DerHautarzt.50460537.eng.abstr-s8-t5",
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},
{
"id": "DerHautarzt.50460537.eng.abstr-s8-t6",
"type": "umlsterm",
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"normalized": [
{
"db_name": "UMLS",
"db_id": "C0235752"
}
]
}
] |
[] |
[] |
[
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{
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{
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{
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{
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{
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{
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{
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DerHautarzt.50460553.eng.abstr
|
DerHautarzt.50460553.eng.abstr
|
[
{
"id": "DerHautarzt.50460553.eng.abstr-passage-0",
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"text": [
"We describe the case of a 65-yearold female patient with cutaneous Langerhans ' cell granulomatosis without any signs of disease in other organs . She also had systemic lupus erythematosus that had been diagnosed several years before . The coexistence of these two diseases has not been described before as far as we know . The purine analogue 2-chlorodeoxyadenosine ( Cladribin ) , which has been used successfully in the treatment of hairy cell leukaemia , induced complete remission in our patient after 1 week of treatment . After 2 months , however , the patient had a relapse ; this was successfully treated with thalidomide . A new understanding of Langerhans ' cell granulomatosis as a reactive but not cancerous disease has emerged as a result of recent investigations showing that tumour necrosis factor- ( TNF- ) plays an important part in the induction of Langerhans ' cells from their immature precursors . Because thalidomide has been shown to inhibit TNF- production , down-modulation of this cytokine seems to be a useful treatment strategy in Langerhans ' cell granulomatosis . Some aspects of the diagnosis and therapy of this disease are briefly reviewed ."
],
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[
0,
1175
]
]
}
] |
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DerHautarzt.50460561.eng.abstr
|
DerHautarzt.50460561.eng.abstr
|
[
{
"id": "DerHautarzt.50460561.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Generalized granuloma annulare is a rare variant of granuloma annulare affecting the trunk and extremities with a multitude of lesions . In contrast to localized granuloma annulare , generalized granuloma annulare occurs in older patients , shows a stronger association with diabetes , and is characteristically chronic . Like our 55-year-old patient , most patients present with papules and annular plaques ; less often , macular or non-annular lesions may be encountered . Histology often fails to show necrobiotic or necrotic connective tissue changes demarcated by a palisading granuloma . Instead , there are diffuse dermal , band-like or nodular aggregations of histiocytes intermingled with some multinucleated giant cells and a predominantly lymphocytic infiltrate in the periphery . Because of its special characteristics , it has been suggested that generalized granuloma annulare might constitute a separate disease entity and that it should be classed among the primary cutaneous histiocytoses as a diffuse dermal histiocytosis . Using immunohistochemistry to determine the macrophage phenotype of the lesional histiocytes , we have shown that generalized granuloma annulare is not a cutaneous histiocytosis . Neither MS-1 high-molecular-weight protein , a new specific marker for cutaneous non-Langerhans cell histiocytoses , nor CD1a, the well-known marker for Langerhans cells and Langerhans cell histiocytoses , is expressed by the lesional histiocytes of our patient . In contrast , the antigen expression pattern was diagnostic for non-infectious granulomas and was highly similar to that in localized granuloma annulare . In contrast to the successful treatment of localized granuloma annulare reported with intralesional interferon -1 , systemic treatment with interferon -2b ( 9x106 units three times a week ) was ineffective ."
],
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] |
DerHautarzt.50460568.eng.abstr
|
DerHautarzt.50460568.eng.abstr
|
[
{
"id": "DerHautarzt.50460568.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Polyarteritis nodosa is a multi-systemic vasculitic disease process involving small and medium-sized arteries throughout the body . Cutaneous polyarteritis nodosa has been described as a limited form involving the skin , skeletal muscles , and peripheral nerves . A protracted course of 20 years or longer , with few cases eventually developing visceral involvement , has been emphasized by many authors . A case of polyarteritis with a 20-year history of exacerbations and spontaneous remissions that never seriously compromised the patient's health is presented . The initial and predominant symptoms were leg pains , Raynaud's phenomenon , and nail defects ( onychoschizia ) ."
],
"offsets": [
[
0,
679
]
]
}
] |
[
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],
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]
],
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"db_id": "C0012634"
}
]
},
{
"id": "DerHautarzt.50460568.eng.abstr-s1-t2",
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"text": [
"arteries"
],
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101,
109
]
],
"normalized": [
{
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"db_id": "C0003842"
}
]
},
{
"id": "DerHautarzt.50460568.eng.abstr-s1-t3",
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"Polyarteritis nodosa"
],
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[
0,
20
]
],
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{
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"db_id": "C0031036"
}
]
},
{
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"form"
],
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199
]
],
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},
{
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],
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[
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218
]
],
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}
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},
{
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],
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237
]
],
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},
{
"id": "DerHautarzt.50460568.eng.abstr-s2-t4",
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"nerves"
],
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255,
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},
{
"id": "DerHautarzt.50460568.eng.abstr-s2-t5",
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],
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},
{
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],
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221,
237
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],
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"db_id": "C0242695"
}
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},
{
"id": "DerHautarzt.50460568.eng.abstr-s2-t7",
"type": "umlsterm",
"text": [
"peripheral nerves"
],
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244,
261
]
],
"normalized": [
{
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},
{
"id": "DerHautarzt.50460568.eng.abstr-s4-t1",
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"history"
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},
{
"id": "DerHautarzt.50460568.eng.abstr-s4-t2",
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],
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}
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},
{
"id": "DerHautarzt.50460568.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"spontaneous remissions"
],
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],
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},
{
"id": "DerHautarzt.50460568.eng.abstr-s5-t1",
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],
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]
],
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]
},
{
"id": "DerHautarzt.50460568.eng.abstr-s5-t2",
"type": "umlsterm",
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],
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]
],
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},
{
"id": "DerHautarzt.50460568.eng.abstr-s5-t3",
"type": "umlsterm",
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],
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"db_id": "C0027342"
}
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},
{
"id": "DerHautarzt.50460568.eng.abstr-s5-t4",
"type": "umlsterm",
"text": [
"defects"
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] |
[] |
[] |
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] |
DerHautarzt.50460573.eng.abstr
|
DerHautarzt.50460573.eng.abstr
|
[
{
"id": "DerHautarzt.50460573.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report on a 59-year-old woman patient with selective IgA deficiency and familial hypercholesterinaemia . To lower elevated LDL levels in the patient's blood , immunoadsorption therapy with sheep-anti-human polyclonal antibodies coupled to sepharose columns was administered . During the procedure , the patient developed an anaphylactic shock requiring intensive care treatment . The patient's history revealed a fresh cell therapy with fetal sheep cells 10 years previously . Intracutaneous testing confirmed sensitization to sheep immunoglobulin , which was the most likely reason for the anaphylactic shock ."
],
"offsets": [
[
0,
614
]
]
}
] |
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] |
[] |
[] |
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},
{
"id": "DerHautarzt.50460573.eng.abstr-s5-r16-t5.1-t4.1",
"type": "degree_of",
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},
{
"id": "DerHautarzt.50460573.eng.abstr-s5-r17-t1.1-t5.1",
"type": "associated_with",
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"arg2_id": "DerHautarzt.50460573.eng.abstr-s5-t5",
"normalized": []
},
{
"id": "DerHautarzt.50460573.eng.abstr-s5-r18-t4.1-t5.1",
"type": "associated_with",
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"arg2_id": "DerHautarzt.50460573.eng.abstr-s5-t5",
"normalized": []
},
{
"id": "DerHautarzt.50460573.eng.abstr-s5-r19-t1.1-t4.1",
"type": "associated_with",
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"arg2_id": "DerHautarzt.50460573.eng.abstr-s5-t4",
"normalized": []
}
] |
DerHautarzt.50460576.eng.abstr
|
DerHautarzt.50460576.eng.abstr
|
[
{
"id": "DerHautarzt.50460576.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 34-year-old women had a hen's egg-sized supernumerary mammary gland with no nipple or areola in the left anterior axillary line for the last 8 years . The main complaint about the axillary \" lump \" was that it was aesthetically displeasing , and it was excised . The importance of an axillary breast lies in the possibility that pathologic changes could develop in its substance and that clinically it could be confused with a lipoma . Early diagnosis and correct excision are usually recommended ."
],
"offsets": [
[
0,
500
]
]
}
] |
[
{
"id": "DerHautarzt.50460576.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"women"
],
"offsets": [
[
14,
19
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0043210"
}
]
},
{
"id": "DerHautarzt.50460576.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"hen's"
],
"offsets": [
[
26,
31
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0605770"
}
]
},
{
"id": "DerHautarzt.50460576.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"nipple"
],
"offsets": [
[
78,
84
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0028109"
}
]
},
{
"id": "DerHautarzt.50460576.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"anterior"
],
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[
107,
115
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0032008"
}
]
},
{
"id": "DerHautarzt.50460576.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"line"
],
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[
125,
129
]
],
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"db_name": "UMLS",
"db_id": "C0677502"
}
]
},
{
"id": "DerHautarzt.50460576.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"mammary gland"
],
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[
56,
69
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0006141"
}
]
},
{
"id": "DerHautarzt.50460576.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"breast"
],
"offsets": [
[
295,
301
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0006141"
},
{
"db_name": "UMLS",
"db_id": "C0006142"
}
]
},
{
"id": "DerHautarzt.50460576.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"pathologic"
],
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331,
341
]
],
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"db_id": "C0205469"
}
]
},
{
"id": "DerHautarzt.50460576.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"lipoma"
],
"offsets": [
[
429,
435
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0023798"
}
]
},
{
"id": "DerHautarzt.50460576.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"diagnosis"
],
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[
444,
453
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011900"
},
{
"db_name": "UMLS",
"db_id": "C0348026"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.50460576.eng.abstr-s1-r1-t6.1-t2.1",
"type": "produces",
"arg1_id": "DerHautarzt.50460576.eng.abstr-s1-t6",
"arg2_id": "DerHautarzt.50460576.eng.abstr-s3-t2",
"normalized": []
},
{
"id": "DerHautarzt.50460576.eng.abstr-s1-r2-t4.1-t2.1",
"type": "produces",
"arg1_id": "DerHautarzt.50460576.eng.abstr-s1-t4",
"arg2_id": "DerHautarzt.50460576.eng.abstr-s3-t2",
"normalized": []
},
{
"id": "DerHautarzt.50460576.eng.abstr-s1-r3-t5.1-t2.1",
"type": "interacts_with",
"arg1_id": "DerHautarzt.50460576.eng.abstr-s1-t5",
"arg2_id": "DerHautarzt.50460576.eng.abstr-s3-t2",
"normalized": []
},
{
"id": "DerHautarzt.50460576.eng.abstr-s1-r4-t2.1-t5.1",
"type": "interacts_with",
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"arg2_id": "DerHautarzt.50460576.eng.abstr-s1-t5",
"normalized": []
},
{
"id": "DerHautarzt.50460576.eng.abstr-s1-r5-t6.1-t5.1",
"type": "produces",
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"arg2_id": "DerHautarzt.50460576.eng.abstr-s1-t5",
"normalized": []
},
{
"id": "DerHautarzt.50460576.eng.abstr-s1-r6-t4.1-t5.1",
"type": "produces",
"arg1_id": "DerHautarzt.50460576.eng.abstr-s1-t4",
"arg2_id": "DerHautarzt.50460576.eng.abstr-s1-t5",
"normalized": []
},
{
"id": "DerHautarzt.50460576.eng.abstr-s1-r7-t2.1-t5.1",
"type": "produces",
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"arg2_id": "DerHautarzt.50460576.eng.abstr-s1-t5",
"normalized": []
}
] |
DerHautarzt.50460579.eng.abstr
|
DerHautarzt.50460579.eng.abstr
|
[
{
"id": "DerHautarzt.50460579.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We present a 58-year-old patient with disseminated aspergillosis and metastatic panniculitis . He suffered from agranulocytosis and blastic transformation of a myelodysplastic syndrome . The skin lesion showed a single subcutaneous inflammatory nodule , which was clearly shown by histolog to be of embolic origin . This clinical presentation has not previously been described . Disseminated aspergillosis is found mainly in immunocompromised and neutropenic patients and the mortality is high . The present case demonstrates how histological examination together with skin biopsy culture can allow the diagnosis ."
],
"offsets": [
[
0,
614
]
]
}
] |
[
{
"id": "DerHautarzt.50460579.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"patient"
],
"offsets": [
[
25,
32
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.50460579.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"aspergillosis"
],
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[
51,
64
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0004030"
}
]
},
{
"id": "DerHautarzt.50460579.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"metastatic"
],
"offsets": [
[
69,
79
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0036525"
}
]
},
{
"id": "DerHautarzt.50460579.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"panniculitis"
],
"offsets": [
[
80,
92
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030326"
}
]
},
{
"id": "DerHautarzt.50460579.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"agranulocytosis"
],
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[
112,
127
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0001824"
}
]
},
{
"id": "DerHautarzt.50460579.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"syndrome"
],
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[
176,
184
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0039082"
}
]
},
{
"id": "DerHautarzt.50460579.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"myelodysplastic syndrome"
],
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[
160,
184
]
],
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{
"db_name": "UMLS",
"db_id": "C0026986"
}
]
},
{
"id": "DerHautarzt.50460579.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"skin"
],
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191,
195
]
],
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{
"db_name": "UMLS",
"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.50460579.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"single"
],
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[
212,
218
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0087136"
}
]
},
{
"id": "DerHautarzt.50460579.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"origin"
],
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307,
313
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0079946"
}
]
},
{
"id": "DerHautarzt.50460579.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"aspergillosis"
],
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392,
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]
],
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"db_name": "UMLS",
"db_id": "C0004030"
}
]
},
{
"id": "DerHautarzt.50460579.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"immunocompromised"
],
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425,
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]
],
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"db_name": "UMLS",
"db_id": "C0085393"
}
]
},
{
"id": "DerHautarzt.50460579.eng.abstr-s5-t3",
"type": "umlsterm",
"text": [
"patients"
],
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]
],
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"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.50460579.eng.abstr-s5-t4",
"type": "umlsterm",
"text": [
"mortality"
],
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476,
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],
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"db_id": "C0026566"
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"db_id": "C0026565"
}
]
},
{
"id": "DerHautarzt.50460579.eng.abstr-s6-t1",
"type": "umlsterm",
"text": [
"skin"
],
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569,
573
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],
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"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.50460579.eng.abstr-s6-t2",
"type": "umlsterm",
"text": [
"biopsy"
],
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574,
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],
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"db_id": "C0220797"
},
{
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}
]
},
{
"id": "DerHautarzt.50460579.eng.abstr-s6-t3",
"type": "umlsterm",
"text": [
"culture"
],
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581,
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"db_name": "UMLS",
"db_id": "C0220814"
},
{
"db_name": "UMLS",
"db_id": "C0010453"
}
]
},
{
"id": "DerHautarzt.50460579.eng.abstr-s6-t4",
"type": "umlsterm",
"text": [
"diagnosis"
],
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603,
612
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],
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"db_id": "C0011900"
},
{
"db_name": "UMLS",
"db_id": "C0348026"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.50460579.eng.abstr-s1-r1-t3.1-t1.1",
"type": "occurs_in",
"arg1_id": "DerHautarzt.50460579.eng.abstr-s6-t3",
"arg2_id": "DerHautarzt.50460579.eng.abstr-s6-t1",
"normalized": []
},
{
"id": "DerHautarzt.50460579.eng.abstr-s1-r2-t2.1-t1.1",
"type": "occurs_in",
"arg1_id": "DerHautarzt.50460579.eng.abstr-s6-t2",
"arg2_id": "DerHautarzt.50460579.eng.abstr-s6-t1",
"normalized": []
},
{
"id": "DerHautarzt.50460579.eng.abstr-s2-r1-t2.1-t3.1",
"type": "degree_of",
"arg1_id": "DerHautarzt.50460579.eng.abstr-s6-t2",
"arg2_id": "DerHautarzt.50460579.eng.abstr-s6-t3",
"normalized": []
},
{
"id": "DerHautarzt.50460579.eng.abstr-s2-r2-t1.1-t3.1",
"type": "degree_of",
"arg1_id": "DerHautarzt.50460579.eng.abstr-s6-t1",
"arg2_id": "DerHautarzt.50460579.eng.abstr-s6-t3",
"normalized": []
},
{
"id": "DerHautarzt.50460579.eng.abstr-s2-r3-t3.1-t2.1",
"type": "degree_of",
"arg1_id": "DerHautarzt.50460579.eng.abstr-s6-t3",
"arg2_id": "DerHautarzt.50460579.eng.abstr-s6-t2",
"normalized": []
},
{
"id": "DerHautarzt.50460579.eng.abstr-s2-r4-t3.1-t1.1",
"type": "degree_of",
"arg1_id": "DerHautarzt.50460579.eng.abstr-s6-t3",
"arg2_id": "DerHautarzt.50460579.eng.abstr-s6-t1",
"normalized": []
},
{
"id": "DerHautarzt.50460579.eng.abstr-s5-r1-t1.1-t3.1",
"type": "occurs_in",
"arg1_id": "DerHautarzt.50460579.eng.abstr-s6-t1",
"arg2_id": "DerHautarzt.50460579.eng.abstr-s6-t3",
"normalized": []
},
{
"id": "DerHautarzt.50460579.eng.abstr-s5-r2-t1.1-t2.1",
"type": "affects",
"arg1_id": "DerHautarzt.50460579.eng.abstr-s6-t1",
"arg2_id": "DerHautarzt.50460579.eng.abstr-s6-t2",
"normalized": []
},
{
"id": "DerHautarzt.50460579.eng.abstr-s5-r3-t3.1-t4.1",
"type": "uses",
"arg1_id": "DerHautarzt.50460579.eng.abstr-s6-t3",
"arg2_id": "DerHautarzt.50460579.eng.abstr-s6-t4",
"normalized": []
},
{
"id": "DerHautarzt.50460579.eng.abstr-s6-r1-t1.1-t3.1",
"type": "isa",
"arg1_id": "DerHautarzt.50460579.eng.abstr-s6-t1",
"arg2_id": "DerHautarzt.50460579.eng.abstr-s6-t3",
"normalized": []
},
{
"id": "DerHautarzt.50460579.eng.abstr-s6-r2-t3.1-t4.1",
"type": "evaluation_of",
"arg1_id": "DerHautarzt.50460579.eng.abstr-s6-t3",
"arg2_id": "DerHautarzt.50460579.eng.abstr-s6-t4",
"normalized": []
},
{
"id": "DerHautarzt.50460579.eng.abstr-s6-r3-t1.1-t4.2",
"type": "isa",
"arg1_id": "DerHautarzt.50460579.eng.abstr-s6-t1",
"arg2_id": "DerHautarzt.50460579.eng.abstr-s6-t4",
"normalized": []
},
{
"id": "DerHautarzt.50460579.eng.abstr-s6-r4-t3.1-t2.1",
"type": "evaluation_of",
"arg1_id": "DerHautarzt.50460579.eng.abstr-s6-t3",
"arg2_id": "DerHautarzt.50460579.eng.abstr-s6-t2",
"normalized": []
},
{
"id": "DerHautarzt.50460579.eng.abstr-s6-r5-t1.1-t2.1",
"type": "location_of",
"arg1_id": "DerHautarzt.50460579.eng.abstr-s6-t1",
"arg2_id": "DerHautarzt.50460579.eng.abstr-s6-t2",
"normalized": []
},
{
"id": "DerHautarzt.50460579.eng.abstr-s6-r6-t4.2-t3.1",
"type": "isa",
"arg1_id": "DerHautarzt.50460579.eng.abstr-s6-t4",
"arg2_id": "DerHautarzt.50460579.eng.abstr-s6-t3",
"normalized": []
},
{
"id": "DerHautarzt.50460579.eng.abstr-s6-r7-t1.1-t4.1",
"type": "location_of",
"arg1_id": "DerHautarzt.50460579.eng.abstr-s6-t1",
"arg2_id": "DerHautarzt.50460579.eng.abstr-s6-t4",
"normalized": []
}
] |
DerHautarzt.50460603.eng.abstr
|
DerHautarzt.50460603.eng.abstr
|
[
{
"id": "DerHautarzt.50460603.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Guanine nucleotide-binding proteins ( G proteins ) function as transducers of information across the cell membrane by coupling receptors to effectors . A large number of G protein-linked receptors funnel extra-cellular signals as diverse as hormones , growth factors , neurotransmitters , and primary sensory stimuli through a set of G proteins to a small number of second-messenger systems . The G proteins act as molecular switches with an \" on \" and \" off \" state governed by a GTPase cycle . By virtue of its high affinity and specificity for guanine nucleotide binding and its intrinsic GTPase activity , the -subunit of the G protein ( G ) plays the critical role in regulation of the effectors by their corresponding G protein . Mutations of G may result in either constitutive activation or loss of expression mutations . Given the variety of functions subserved by G protein-coupled signal transduction , it is not surprising that abnormalities in G protein-coupled pathways can lead to diseases with manifestations as dissimilar as blindness , hormone resistance , precocious puberty and neoplasia . For a given defect in a G protein-coupled pathway , the extent of the manifestations will also be determined by the cellular distribution of the affected component . Defects in components expressed exclusively in a single cell type will cause more a focal disorder than defects in a widely expressed component , particularly in germline mutations ( e.g. , Albright's hereditary osteodystrophy ) , whereas somatic mutations of genes encoding even an ubiquitously expressed component can cause focal disease when the somatic mutation itself is focal ( e.g. , McCune-Albright syndrome ) ."
],
"offsets": [
[
0,
1695
]
]
}
] |
[
{
"id": "DerHautarzt.50460603.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"Guanine"
],
"offsets": [
[
0,
7
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018321"
}
]
},
{
"id": "DerHautarzt.50460603.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"nucleotide-binding"
],
"offsets": [
[
8,
26
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0028630"
}
]
},
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] |
[] |
[] |
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DerHautarzt.50460607.eng.abstr
|
DerHautarzt.50460607.eng.abstr
|
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"Micrographic surgery is one of the most effective methods in the treatment of basal cell carcinoma . In the last 20 years this method has been further developed and modified . Three kinds of micrographic surgery are now available : the Mohs method , the margin strip method ( \" Tuebingen torte \" ) and the \" Munich \" method . All three variants have the same goal ; radical tumour removal with optimal sparing of surroundind tumour-free tissue . They differ , however , in the technique of tumour excision , the preparation of the histological specimens and the interpretation of the slides . In this paper the authors take stock of the methods available and describe the differences , advantages and disadvantages ."
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[] |
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DerHautarzt.50460620.eng.abstr
|
DerHautarzt.50460620.eng.abstr
|
[
{
"id": "DerHautarzt.50460620.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Cicatricial pemphigoid is an autoimmune subepidermal blistering disease of the skin and mucous membranes . We report on eight patients in whom the clinical diagnosis was confirmed by direct immunofluorescence . The patients ' age averaged 69 years ; seven were female and one male . Initial symptoms were erosions of the oral mucous membranes in four patients , skin blisters in three patients , and in one patient an ocular involvement was the first manifestation of the disease . Indirect immunofluorescence on NaCl-split human skin revealed circulating IgG antibodies binding to the roof of the artificial blister in three patients . Immunoblotting of epidermal and dermal extracts disclosed binding of IgG antibodies of one of these patients to an epidermal 230-kD protein , whereas IgA-antibodies showed no specific binding . In four of five patients with a strong ocular involvement IgA deposits were found by direct immunofluorescence . These studies were done on biopsies of perilesional skin or oral mucous membranes , and they were positive in one patient even before the first ocular lesions appeared . Therefore , finding of IgA deposits by direct immunofluorescence may be taken as a prognostic criterion allowing selection of the proper treatment . We treated six patients with a dexamethasone-cyclophosphamide pulse therapy , while two patients received dapsone orally . The involvement of skin and oral mucous membrane responded well to both regimens , whereas the ocular lesions were progressive , except in one patient . On the basis of our eight cases , we discuss both options and limitations in the treatment of cicatricial pemphigoid and review new aspects of the pathogenesis of this disease ."
],
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0,
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DerHautarzt.50460632.eng.abstr
|
DerHautarzt.50460632.eng.abstr
|
[
{
"id": "DerHautarzt.50460632.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Classic and HIV-associated Kaposi's sarcoma ( KS ) are predominantly found in male Caucasians . It is unclear why KS is so rare in women . At the Department of Dermatology , University of Frankfurt , epidemic KS was diagnosed in 299/751 ( 40% ) male and 5/72 ( 18% ) female HIV-infected patients . To detect common parameters regarding immunodeficiency , hormonal disturbances , abnormalities in clinical course , or sexual practices , data of eight women with KS ( five HIV+, three HIV- ) were compared . In HIV+ women KS is more aggressive than in HIV- women and more aggressive than in HIV+ men . Early and frequent visceral involvement and no preference for the lower extremities are found . Compared to HIV- women with KS , HIV+ women are generally younger ( mean age 38 vs 71 years ) and significantly immunodeficient ( reduced absolute CD4 cell count and CD4/CD8 ratio ) . All women with KS investigated for sexual hormones ( 7/8 ) showed abnormalities : 7/7 had low oestrogens , 4/6 low LH and 3/5 low progesterone . Controls ( n=11, HIV+ without KS ) showed a clear trend for higher serum levels of sexual hormones , but the difference was not significant . Although different reasons for low levels of oestrogens ( drug abuse , marasmus , menopause ) must be considered , the lack of oestrogens seems to be a common finding in HIV+ and HIV- women with KS . There was no correlation between sexual practices ( anal or oral-faecal contacts ) and the manifestation or aggressiveness of KS ."
],
"offsets": [
[
0,
1497
]
]
}
] |
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],
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36,
43
]
],
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},
{
"id": "DerHautarzt.50460632.eng.abstr-s1-t2",
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"text": [
"male"
],
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[
78,
82
]
],
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},
{
"id": "DerHautarzt.50460632.eng.abstr-s1-t3",
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],
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],
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{
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136
]
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},
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"id": "DerHautarzt.50460632.eng.abstr-s3-t3",
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},
{
"id": "DerHautarzt.50460632.eng.abstr-s3-t4",
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}
] |
DerHautarzt.50460638.eng.abstr
|
DerHautarzt.50460638.eng.abstr
|
[
{
"id": "DerHautarzt.50460638.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report on a 56-year-old renal allograft recipient receiving cyclosporin A immunosuppression . During this therapy he subsequently developed the following cutaneous neoplasms : squamous cell carcinomas , basal cell carcinomas , Bowen's disease , actinic keratosis , sebaceous hyperplasia , a dysplastic naevus and , finally a nodular malignant melanoma . Adverse effects of the cyclosporin A therapy are discussed , with special reference to dermatologic effects and the implications for patient and doctor ."
],
"offsets": [
[
0,
510
]
]
}
] |
[
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"id": "DerHautarzt.50460638.eng.abstr-s1-t1",
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"cyclosporin"
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63,
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{
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}
]
},
{
"id": "DerHautarzt.50460638.eng.abstr-s1-t2",
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"immunosuppression"
],
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},
{
"id": "DerHautarzt.50460638.eng.abstr-s1-t3",
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"cyclosporin A"
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63,
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"id": "DerHautarzt.50460638.eng.abstr-s2-t1",
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"therapy"
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},
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"id": "DerHautarzt.50460638.eng.abstr-s2-t3",
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"cell"
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"id": "DerHautarzt.50460638.eng.abstr-s2-t4",
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{
"id": "DerHautarzt.50460638.eng.abstr-s2-t5",
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},
{
"id": "DerHautarzt.50460638.eng.abstr-s2-t6",
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"carcinomas"
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217,
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{
"id": "DerHautarzt.50460638.eng.abstr-s2-t7",
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"id": "DerHautarzt.50460638.eng.abstr-s2-t8",
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{
"id": "DerHautarzt.50460638.eng.abstr-s2-t9",
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"disease"
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"id": "DerHautarzt.50460638.eng.abstr-s2-t10",
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"keratosis"
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"id": "DerHautarzt.50460638.eng.abstr-s2-t11",
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"db_id": "C0020507"
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},
{
"id": "DerHautarzt.50460638.eng.abstr-s2-t12",
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"naevus"
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},
{
"id": "DerHautarzt.50460638.eng.abstr-s2-t13",
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{
"id": "DerHautarzt.50460638.eng.abstr-s2-t14",
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"id": "DerHautarzt.50460638.eng.abstr-s2-t15",
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{
"id": "DerHautarzt.50460638.eng.abstr-s2-t16",
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"id": "DerHautarzt.50460638.eng.abstr-s2-t17",
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{
"id": "DerHautarzt.50460638.eng.abstr-s2-t18",
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"id": "DerHautarzt.50460638.eng.abstr-s3-t1",
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"id": "DerHautarzt.50460638.eng.abstr-s3-t7",
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] |
[] |
[] |
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] |
DerHautarzt.50460643.eng.abstr
|
DerHautarzt.50460643.eng.abstr
|
[
{
"id": "DerHautarzt.50460643.eng.abstr-passage-0",
"type": "abstract",
"text": [
"This case report refers to a German patient with sterile eosinophilic pustulosis of the Ofuji type ( SEP ) , which is rarely described in non-Japanese humans . The distinctive histomorphology , with intraepidermal eosinophilic abscesses and eosinophilic folliculitis , is complemented in this patient by marked eosinophilia , evident eosinophilic bone marrow reaction and involvement of the oral mucosa with eosinophilic spongiosis , which is a feature that had not previously been reported . Possible transitions between cutaneous and internal hypereosinophilic syndromes are discussed . Despite the initial good effect of topical corticosteroids on the cutaneous changes , long-term follow-up to check for internal involvement is necessary ."
],
"offsets": [
[
0,
743
]
]
}
] |
[
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[] |
[] |
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DerHautarzt.50460647.eng.abstr
|
DerHautarzt.50460647.eng.abstr
|
[
{
"id": "DerHautarzt.50460647.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 34-year-old woman who was 20 weeks pregnant developed pyoderma gangrenosum while receiving treatment for infarct pneumonia . Because of her septic condition an abortion was performed . The patient received intravenous prednisolone as a pulse treatment for her pyoderma gangrenosum , which was followed by oral methylprednisolone and oral dapsone for 6 weeks . After dose reduction the patient had a severe relapse . The steroid dose was increased and dapsone was replaced by cyclosporin A. The smaller ulcers healed spontaneously , but skin grafting had to be performed for the large ulcer . The steroid therapy was tapered and discontinued . Cyclosporin A was continued for 10 weeks as monotherapy . Subsequently , the patient was free of symptoms for 7 months . Twelve months after the diagnosis of pyoderma gangrenosum the patient developed acute myeloid leukaemia accompanied by a recurrence of the skin disease ."
],
"offsets": [
[
0,
919
]
]
}
] |
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"id": "DerHautarzt.50460647.eng.abstr-s1-t2",
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],
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{
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"prednisolone"
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},
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"id": "DerHautarzt.50460647.eng.abstr-s3-t3",
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"pulse"
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},
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"id": "DerHautarzt.50460647.eng.abstr-s3-t5",
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},
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},
{
"id": "DerHautarzt.50460647.eng.abstr-s3-t8",
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},
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"id": "DerHautarzt.50460647.eng.abstr-s5-t3",
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},
{
"id": "DerHautarzt.50460647.eng.abstr-s5-t6",
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},
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DerHautarzt.50460651.eng.abstr
|
DerHautarzt.50460651.eng.abstr
|
[
{
"id": "DerHautarzt.50460651.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A case of multiple eccrine spiradenomata is reported . One of the tumours was histopathologically associated with dermal cylindroma , and immunohistochemical studies showed that the cylindroma cells differentiate towards the secreting portion of the eccrine sweat gland . The relationship among multiple eccrine spiradenomata , dermal cylindroma and multiple trichoepitheliomata is discussed ."
],
"offsets": [
[
0,
393
]
]
}
] |
[
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"tumours"
],
"offsets": [
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66,
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]
],
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},
{
"id": "DerHautarzt.50460651.eng.abstr-s2-t2",
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],
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]
],
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{
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],
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]
],
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{
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],
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],
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{
"id": "DerHautarzt.50460651.eng.abstr-s2-t5",
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{
"id": "DerHautarzt.50460651.eng.abstr-s2-t6",
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"sweat gland"
],
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[] |
[] |
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] |
DerHautarzt.50460656.eng.abstr
|
DerHautarzt.50460656.eng.abstr
|
[
{
"id": "DerHautarzt.50460656.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 58-year-old man presented with a solitary , asymptomatic , firm nodular lesion on his glans . A simple excision was carried out . Follow-up for 1 year failed to reveal either recurrence or metastases . Histologically , there was intradermal proliferation of atypical oval and spindle-shaped cells arranged in fascicles simulating the pattern of neural tumours . Mitotic figures were abundant . Stains for melanin , HMB-45 antigen were negative . Immunohistochemically , tumour cells stained for S-100 protein and vimentin . Malignant schwannoma usually occurs in patients with neurofibromatosis and is located in the subcutaneous tissues . Solitary malignant schwannoma of superficial soft tissue is a rare entity , and there are problems of differential diagnosis against other spindle cell tumours , especially malignant spindle cell melanoma . Their appearance on the glans is rare ."
],
"offsets": [
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0,
888
]
]
}
] |
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}
]
}
] |
[] |
[] |
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DerHautarzt.50460676.eng.abstr
|
DerHautarzt.50460676.eng.abstr
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"The vast body of knowledge on interleukin-7 ( IL-7) that has accumulated over the last few years , i.e. since its discovery in 1988 , is of increasing relevance for dermatologists . Because of its particular immunological effects , IL-7 is of particular interest in two areas of dermatology . First , IL-7 can be a valuable addition to immunotherapeutic approaches to the treatment of malignant melanoma . A first pilot study of IL-7 gene-modified autologous tumour cells in the treatment of metastatic melanoma is therefore currently being initiated by the authors . Then , keratinocytes are efficient IL-7-secreting cells and there is evidence that IL-7 can modulate the presence and proliferation of normal and malignant lymphopoietic cells in the dermis . In addition , IL-7 is presently the most potent growth factor for in vitro cultivation of Sézary cells and for the establishment of Sézary cell lines . This report reviews molecular , immunological and preclinical properties of IL-7, with special reference to the possible therapeutic efficacy of this cytokine in dermatology ."
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[] |
[] |
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] |
DerHautarzt.50460693.eng.abstr
|
DerHautarzt.50460693.eng.abstr
|
[
{
"id": "DerHautarzt.50460693.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A total of 222 urogenital specimens were investigated with a commercially available polymerase chain reaction ( Amplicor test ) for the direct detection of Chlamydia trachomatis . The results were compared with those yielded by the conventional cell culture technique . Using cell culture a urogenital C. trachomatis infection could be detected in 72 of 222 patients . The Amplicor test yielded a positive result in 83. Referred to the detection rate of the Amplicor test and that of the cell culture , sensitivity was 91.2% for the test sensitivity and 79.1% for the cell culture . The specificity of both techniques was 100% when the specimens for which neither both nor either one of the tests gave positive results were considered . In accordance with other studies , this study suggests that tests based on nucleic acid amplification will supersede cell cultures as the gold standard for the detection of C. trachomatis and also become the method of choice in routine diagnosis of urogenital chamydial infections ."
],
"offsets": [
[
0,
1019
]
]
}
] |
[
{
"id": "DerHautarzt.50460693.eng.abstr-s1-t1",
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"text": [
"Amplicor"
],
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[
112,
120
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0001465"
}
]
},
{
"id": "DerHautarzt.50460693.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"Amplicor"
],
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[
112,
120
]
],
"normalized": [
{
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"db_id": "C0018787"
}
]
},
{
"id": "DerHautarzt.50460693.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"test"
],
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[
121,
125
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0076174"
}
]
},
{
"id": "DerHautarzt.50460693.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"direct"
],
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[
136,
142
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0700157"
}
]
},
{
"id": "DerHautarzt.50460693.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"Chlamydia"
],
"offsets": [
[
156,
165
]
],
"normalized": [
{
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"db_id": "C0008148"
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{
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"db_id": "C0008149"
}
]
},
{
"id": "DerHautarzt.50460693.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"Chlamydia trachomatis"
],
"offsets": [
[
156,
177
]
],
"normalized": [
{
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"db_id": "C0008151"
}
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},
{
"id": "DerHautarzt.50460693.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"polymerase chain reaction"
],
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DerHautarzt.50460697.eng.abstr
|
DerHautarzt.50460697.eng.abstr
|
[
{
"id": "DerHautarzt.50460697.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Pyoderma gangraenosum can cause great therapeutic problems . High dosed corticosteroids are the treatment of choice . However , recalcitrant pyoderma gangraenosum or side effects from corticosteroid treatment may require therapeutic alternatives . Pyoderma gangraenosum responds excellently to treatment with cyclosporine A. Because of side effects and drug interactions , the patients must be selected and carefully and closely monitored . Six patients with pyoderma gangraenosum , unresponsive to various topical and systemic therapies , were treated with oral cyclosporine A at mean daily doses of approximately 3 mg/kg . Marked improvement of the skin lesions and complete healing occurred in all patients over a period of 3-6 months . Only one patient suffered a relapse after discontinuation of the treatment . No severe irreversible side effects occurred . The results show that low-dose cyclosporine A treatment can be considered a first-line treatment of pyoderma gangraenosum ."
],
"offsets": [
[
0,
987
]
]
}
] |
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] |
DerHautarzt.50460705.eng.abstr
|
DerHautarzt.50460705.eng.abstr
|
[
{
"id": "DerHautarzt.50460705.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In 1901 , Voerner described a diffuse keratoderma of palms and soles with autosomal dominant inheritance . Histopathologically , this disease has the typical features of epidermolytic hyperkeratosis . Clinical examination does not allow differentiation between keratoderma of the Voerner type and the keratoderma described by Thost in 1880 and Unna in 1883. Reexamination of the family originally seen by Thost revealed histopathological signs of epidermolytic hyperkeratosis , confirming that keratoderma of the Voerner type is present in this family . The clinical features and variability of this palmoplantar keratoderma were demonstrated on the basis of an examination of 22 families ( 46 patients ) . In addition to diffuse hyperkeratosis of palms and soles with a sharp demarcation and erythematous margin , some less well-known features , such as knuckle pad-like keratoses on the finger joints and clubbing of the nails were observed . A genetic analysis of the pedigrees suggests that new mutations causing this disorder rarely occur . Point mutations in the keratin 9 gene , which has been mapped to chromosome 17q21, can be a cause of epidermolytic keratoderma of palms and soles . Five different keratin 9 gene mutations were identified . All these mutations are localized in the highly conserved coil 1A region of the rod domain , which is thought to be relevant for dimer formation in intermediate filaments ."
],
"offsets": [
[
0,
1424
]
]
}
] |
[
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"text": [
"soles"
],
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63,
68
]
],
"normalized": [
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"db_id": "C0037613"
}
]
},
{
"id": "DerHautarzt.50460705.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"inheritance"
],
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[
93,
104
]
],
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"db_id": "C0242538"
}
]
},
{
"id": "DerHautarzt.50460705.eng.abstr-s2-t1",
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"text": [
"disease"
],
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141
]
],
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"db_id": "C0012634"
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]
},
{
"id": "DerHautarzt.50460705.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"hyperkeratosis"
],
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[
184,
198
]
],
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"db_id": "C0751995"
}
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},
{
"id": "DerHautarzt.50460705.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"epidermolytic hyperkeratosis"
],
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[
170,
198
]
],
"normalized": [
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"db_id": "C0079153"
}
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},
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"family"
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[
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385
]
],
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}
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},
{
"id": "DerHautarzt.50460705.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"histopathological"
],
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[
420,
437
]
],
"normalized": [
{
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},
{
"id": "DerHautarzt.50460705.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"signs"
],
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[
438,
443
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0220912"
}
]
},
{
"id": "DerHautarzt.50460705.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"hyperkeratosis"
],
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[
461,
475
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0751995"
}
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},
{
"id": "DerHautarzt.50460705.eng.abstr-s3-t5",
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"text": [
"family"
],
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545,
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]
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{
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}
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},
{
"id": "DerHautarzt.50460705.eng.abstr-s3-t6",
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"text": [
"Clinical examination"
],
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201,
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]
],
"normalized": [
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},
{
"id": "DerHautarzt.50460705.eng.abstr-s3-t7",
"type": "umlsterm",
"text": [
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DerHautarzt.50460714.eng.abstr
|
DerHautarzt.50460714.eng.abstr
|
[
{
"id": "DerHautarzt.50460714.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Gianotti-Crosti syndrome , a relatively rare , distinctive eruption occurring after hepatitis B infection , is characterized by a lichenoid papular exanthema , usually localized on the face , limbs , and buttocks . Hepatitis B antigenaemia is associated with Gianotti-Crosti syndrome only in some cases . Recent reports indicate that a variety of infectious agents are associated with Gianotti-Crosti syndrome . This is a report of 21/2-year-old girl with Gianotti-Crosti syndrome and concurrent primary Epstein-Barr virus infection without evidence of hepatitis B infection ."
],
"offsets": [
[
0,
576
]
]
}
] |
[
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],
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16,
24
]
],
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{
"db_name": "UMLS",
"db_id": "C0039082"
}
]
},
{
"id": "DerHautarzt.50460714.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"hepatitis"
],
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[
84,
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]
],
"normalized": [
{
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"db_id": "C0019158"
}
]
},
{
"id": "DerHautarzt.50460714.eng.abstr-s1-t3",
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"text": [
"infection"
],
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[
96,
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]
],
"normalized": [
{
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"db_id": "C0021311"
}
]
},
{
"id": "DerHautarzt.50460714.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"exanthema"
],
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[
148,
157
]
],
"normalized": [
{
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"db_id": "C0015230"
}
]
},
{
"id": "DerHautarzt.50460714.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"face"
],
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[
185,
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]
],
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{
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"db_id": "C0015450"
}
]
},
{
"id": "DerHautarzt.50460714.eng.abstr-s1-t6",
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"text": [
"limbs"
],
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[
192,
197
]
],
"normalized": [
{
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"db_id": "C0015385"
}
]
},
{
"id": "DerHautarzt.50460714.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"buttocks"
],
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[
204,
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]
],
"normalized": [
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},
{
"id": "DerHautarzt.50460714.eng.abstr-s1-t8",
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"text": [
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],
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0,
24
]
],
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]
},
{
"id": "DerHautarzt.50460714.eng.abstr-s1-t9",
"type": "umlsterm",
"text": [
"hepatitis B"
],
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[
84,
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]
],
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}
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},
{
"id": "DerHautarzt.50460714.eng.abstr-s2-t1",
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"text": [
"Hepatitis"
],
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[
215,
224
]
],
"normalized": [
{
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]
},
{
"id": "DerHautarzt.50460714.eng.abstr-s2-t2",
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],
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]
],
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}
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},
{
"id": "DerHautarzt.50460714.eng.abstr-s2-t3",
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],
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]
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]
},
{
"id": "DerHautarzt.50460714.eng.abstr-s2-t4",
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],
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]
],
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[] |
[] |
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DerHautarzt.50460717.eng.abstr
|
DerHautarzt.50460717.eng.abstr
|
[
{
"id": "DerHautarzt.50460717.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report on dermatomyositis-like adverse cutaneous reactions following long-term maintenance therapy with hydroxyurea in two patients suffering from chronic myelogenous leukaemia ( CML ) . In addition to non-specific side effects , such as xerosis , pruritus and hyperpigmentation , both patients presented with more specific skin changes , i.e. erythematous lesions , scaling , and partially atrophic areas distributed in a linear fashion on the dorsal aspects of the hands and fingers . In addition , teleangiectatic erythema of the face was present in both patients , and this was associated with oedema of the eyelids in one patient . Despite these dermatomyositis-like features there were no clinical signs of muscular involvement , and muscle-specific enzymes were within normal ranges . Skin biopsy specimens revealed an interface dermatitis characterized by a lichenoid cell infiltrate , vacuolar alteration of basal cells , necrotic keratinocytes within the spinous zone , focal hypergranulosis , orthohyperkeratosis and telangiectases in the upper part of the dermis . Analogous histopathological findings have been documented in lichen planus-like skin changes on the hands following hydroxyurea therapy . It seems doubtful whether there are actually any major differences between those skin changes described as dermatomyositis-like and those interpreted as lichen planus-like in patients receiving long-term hydroxyurea therapy ."
],
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1443
]
]
}
] |
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"pruritus"
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"type": "property_of",
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"id": "DerHautarzt.50460717.eng.abstr-s7-r21-t4.1-t1.1",
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},
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"id": "DerHautarzt.50460717.eng.abstr-s7-r25-t1.1-t7.1",
"type": "location_of",
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},
{
"id": "DerHautarzt.50460717.eng.abstr-s7-r26-t7.2-t4.1",
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"id": "DerHautarzt.50460717.eng.abstr-s7-r27-t1.1-t2.1",
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"arg2_id": "DerHautarzt.50460717.eng.abstr-s7-t2",
"normalized": []
}
] |
DerHautarzt.50460722.eng.abstr
|
DerHautarzt.50460722.eng.abstr
|
[
{
"id": "DerHautarzt.50460722.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report on a patient with an abdominal type of benign symmetrical Launois-Bensaude lipomatosis . New aspects of the pathogenesis of abnormal distribution of the fatty tissue are also discussed ."
],
"offsets": [
[
0,
196
]
]
}
] |
[
{
"id": "DerHautarzt.50460722.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"patient"
],
"offsets": [
[
15,
22
]
],
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{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.50460722.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"lipomatosis"
],
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[
85,
96
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0023801"
}
]
},
{
"id": "DerHautarzt.50460722.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"pathogenesis"
],
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[
118,
130
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0543483"
}
]
},
{
"id": "DerHautarzt.50460722.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"distribution"
],
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[
143,
155
]
],
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{
"db_name": "UMLS",
"db_id": "C0520511"
}
]
},
{
"id": "DerHautarzt.50460722.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"tissue"
],
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[
169,
175
]
],
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{
"db_name": "UMLS",
"db_id": "C0040300"
}
]
},
{
"id": "DerHautarzt.50460722.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"fatty tissue"
],
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[
163,
175
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0001527"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.50460722.eng.abstr-s1-r1-t2.1-t1.1",
"type": "occurs_in",
"arg1_id": "DerHautarzt.50460722.eng.abstr-s2-t2",
"arg2_id": "DerHautarzt.50460722.eng.abstr-s2-t1",
"normalized": []
}
] |
DerHautarzt.50460726.eng.abstr
|
DerHautarzt.50460726.eng.abstr
|
[
{
"id": "DerHautarzt.50460726.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A case of a 53-year-old chronically uraemic female patient who suddenly developed widespread cutaneous necrosis on both thighs is presented . On the basis of the typical histopathological features a diagnosis of calciphylaxis was made and supported by elevated serum parathyroid hormone levels . Calciphylaxis is a rare and serious disease , mostly seen in uraemic patients subjected to chronic haemodialysis . Typical features are calcifying panniculitis and thrombosis of small to medium-sized blood vessels followed by necrosis of the skin . The poor prognosis is due to systemic calcifications of visceral organs . When acute cutaneous necrosis of the skin is encountered in patients with chronic uraemia calciphylaxis should always be considered as a possible cause in the differential diagnosis . Determination of the serum parathyroid hormone level is recommended ."
],
"offsets": [
[
0,
872
]
]
}
] |
[
{
"id": "DerHautarzt.50460726.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"female"
],
"offsets": [
[
44,
50
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0086287"
},
{
"db_name": "UMLS",
"db_id": "C0015780"
}
]
},
{
"id": "DerHautarzt.50460726.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"patient"
],
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[
51,
58
]
],
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{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.50460726.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"necrosis"
],
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[
103,
111
]
],
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{
"db_name": "UMLS",
"db_id": "C0027540"
}
]
},
{
"id": "DerHautarzt.50460726.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"thighs"
],
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[
120,
126
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0039866"
}
]
},
{
"id": "DerHautarzt.50460726.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"histopathological"
],
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[
170,
187
]
],
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{
"db_name": "UMLS",
"db_id": "C0243140"
}
]
},
{
"id": "DerHautarzt.50460726.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"diagnosis"
],
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[
199,
208
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011900"
},
{
"db_name": "UMLS",
"db_id": "C0348026"
}
]
},
{
"id": "DerHautarzt.50460726.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"calciphylaxis"
],
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[
212,
225
]
],
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{
"db_name": "UMLS",
"db_id": "C0006666"
}
]
},
{
"id": "DerHautarzt.50460726.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"parathyroid"
],
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[
267,
278
]
],
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{
"db_name": "UMLS",
"db_id": "C0030517"
},
{
"db_name": "UMLS",
"db_id": "C0030518"
}
]
},
{
"id": "DerHautarzt.50460726.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"parathyroid"
],
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[
267,
278
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030563"
}
]
},
{
"id": "DerHautarzt.50460726.eng.abstr-s2-t6",
"type": "umlsterm",
"text": [
"parathyroid"
],
"offsets": [
[
267,
278
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0040132"
},
{
"db_name": "UMLS",
"db_id": "C0040134"
}
]
},
{
"id": "DerHautarzt.50460726.eng.abstr-s2-t7",
"type": "umlsterm",
"text": [
"hormone"
],
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[
279,
286
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0019932"
}
]
},
{
"id": "DerHautarzt.50460726.eng.abstr-s2-t8",
"type": "umlsterm",
"text": [
"parathyroid hormone"
],
"offsets": [
[
267,
286
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030520"
}
]
},
{
"id": "DerHautarzt.50460726.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"Calciphylaxis"
],
"offsets": [
[
296,
309
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0006666"
}
]
},
{
"id": "DerHautarzt.50460726.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"disease"
],
"offsets": [
[
332,
339
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0012634"
}
]
},
{
"id": "DerHautarzt.50460726.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"patients"
],
"offsets": [
[
365,
373
]
],
"normalized": [
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"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.50460726.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"haemodialysis"
],
"offsets": [
[
395,
408
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0019004"
}
]
},
{
"id": "DerHautarzt.50460726.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"panniculitis"
],
"offsets": [
[
443,
455
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030326"
}
]
},
{
"id": "DerHautarzt.50460726.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"thrombosis"
],
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[
460,
470
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0040053"
}
]
},
{
"id": "DerHautarzt.50460726.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"blood"
],
"offsets": [
[
496,
501
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0005767"
},
{
"db_name": "UMLS",
"db_id": "C0005768"
},
{
"db_name": "UMLS",
"db_id": "C0005835"
}
]
},
{
"id": "DerHautarzt.50460726.eng.abstr-s4-t4",
"type": "umlsterm",
"text": [
"vessels"
],
"offsets": [
[
502,
509
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0005847"
},
{
"db_name": "UMLS",
"db_id": "C0148346"
}
]
},
{
"id": "DerHautarzt.50460726.eng.abstr-s4-t5",
"type": "umlsterm",
"text": [
"necrosis"
],
"offsets": [
[
522,
530
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027540"
}
]
},
{
"id": "DerHautarzt.50460726.eng.abstr-s4-t6",
"type": "umlsterm",
"text": [
"skin"
],
"offsets": [
[
538,
542
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.50460726.eng.abstr-s4-t7",
"type": "umlsterm",
"text": [
"blood vessels"
],
"offsets": [
[
496,
509
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0005847"
}
]
},
{
"id": "DerHautarzt.50460726.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"prognosis"
],
"offsets": [
[
554,
563
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0033325"
}
]
},
{
"id": "DerHautarzt.50460726.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"calcifications"
],
"offsets": [
[
583,
597
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0006660"
}
]
},
{
"id": "DerHautarzt.50460726.eng.abstr-s6-t1",
"type": "umlsterm",
"text": [
"necrosis"
],
"offsets": [
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640,
648
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027540"
}
]
},
{
"id": "DerHautarzt.50460726.eng.abstr-s6-t2",
"type": "umlsterm",
"text": [
"skin"
],
"offsets": [
[
656,
660
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.50460726.eng.abstr-s6-t3",
"type": "umlsterm",
"text": [
"patients"
],
"offsets": [
[
679,
687
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.50460726.eng.abstr-s6-t4",
"type": "umlsterm",
"text": [
"uraemia"
],
"offsets": [
[
701,
708
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0041948"
}
]
},
{
"id": "DerHautarzt.50460726.eng.abstr-s6-t5",
"type": "umlsterm",
"text": [
"calciphylaxis"
],
"offsets": [
[
709,
722
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0006666"
}
]
},
{
"id": "DerHautarzt.50460726.eng.abstr-s6-t6",
"type": "umlsterm",
"text": [
"cause"
],
"offsets": [
[
765,
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]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0015127"
}
]
},
{
"id": "DerHautarzt.50460726.eng.abstr-s6-t7",
"type": "umlsterm",
"text": [
"diagnosis"
],
"offsets": [
[
791,
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]
],
"normalized": [
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] |
DerHautarzt.50460732.eng.abstr
|
DerHautarzt.50460732.eng.abstr
|
[
{
"id": "DerHautarzt.50460732.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A case of multiple lesions of junctional melanocytic hyperplasia arising in a skin graft after excision of a congenital melanocytic naevus is reported . This observation is shown to support the concept of the histogenesis of acquired melanocytic naevi proposed by Cramer [ 2 ] , i.e. that acquired melanocytic naevi are derived from melanocyte precursors located in nerve sheaths , whereas it is inconsistent with notions of the origin of naevogenesis in the epidermal melanocyte ."
],
"offsets": [
[
0,
481
]
]
}
] |
[
{
"id": "DerHautarzt.50460732.eng.abstr-s1-t1",
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"text": [
"hyperplasia"
],
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[
53,
64
]
],
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{
"db_name": "UMLS",
"db_id": "C0020507"
}
]
},
{
"id": "DerHautarzt.50460732.eng.abstr-s1-t2",
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"text": [
"skin"
],
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[
78,
82
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.50460732.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"graft"
],
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[
83,
88
]
],
"normalized": [
{
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"db_id": "C0332835"
},
{
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"db_id": "C0040733"
}
]
},
{
"id": "DerHautarzt.50460732.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"congenital"
],
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[
109,
119
]
],
"normalized": [
{
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"db_id": "C0009678"
}
]
},
{
"id": "DerHautarzt.50460732.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"naevus"
],
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[
132,
138
]
],
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{
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"db_id": "C0027960"
}
]
},
{
"id": "DerHautarzt.50460732.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"skin graft"
],
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[
78,
88
]
],
"normalized": [
{
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"db_id": "C0037297"
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]
},
{
"id": "DerHautarzt.50460732.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"observation"
],
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[
158,
169
]
],
"normalized": [
{
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"db_id": "C0302523"
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]
},
{
"id": "DerHautarzt.50460732.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"naevi"
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[
246,
251
]
],
"normalized": [
{
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"db_id": "C0027960"
}
]
},
{
"id": "DerHautarzt.50460732.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"naevi"
],
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[
310,
315
]
],
"normalized": [
{
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}
]
},
{
"id": "DerHautarzt.50460732.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"melanocyte"
],
"offsets": [
[
333,
343
]
],
"normalized": [
{
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"db_id": "C0025201"
}
]
},
{
"id": "DerHautarzt.50460732.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"nerve"
],
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[
366,
371
]
],
"normalized": [
{
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}
]
},
{
"id": "DerHautarzt.50460732.eng.abstr-s2-t6",
"type": "umlsterm",
"text": [
"origin"
],
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[
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]
],
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{
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"db_id": "C0079946"
}
]
},
{
"id": "DerHautarzt.50460732.eng.abstr-s2-t7",
"type": "umlsterm",
"text": [
"melanocyte"
],
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[
469,
479
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0025201"
}
]
}
] |
[] |
[] |
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DerHautarzt.50460755.eng.abstr
|
DerHautarzt.50460755.eng.abstr
|
[
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"Naturally occurring animal models are not available even for most common skin diseases . Transgenic technology developed during the 1980s is closing this gap . It was initially used as a tool by scientists in basic research , but during the last 5 years it has increasingly been applied by clinically oriented basic researchers in dermatology . This technique , has made it possible to imitate HIV-associated diseases and genodermatoses in the murine model and to elucidate their pathogenesis . Owing to specifically induced epidermally localized overexpression of growth factors and cytokines , the skin of transgenic mice exhibited similarities to those of the psoriatic epidermis . Such animals are also useful for studying wound healing . Furthermore , transgenic technology enables us to induce cutaneous tumors selectively . The availability of animal models for human skin diseases is also of value in elucidating experimental therapeutic approaches , e.g. the somatic gene therapy ."
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[] |
[] |
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DerHautarzt.50460762.eng.abstr
|
DerHautarzt.50460762.eng.abstr
|
[
{
"id": "DerHautarzt.50460762.eng.abstr-passage-0",
"type": "abstract",
"text": [
"During the past decade more than 90% of all melanoma patients in the German-speaking countries have been diagnosed with a primary tumour alone . Therefore , surgical intervention has been the most important element in the management of these patients . The present investigation was performed to analyse the different surgical procedures used in the treatment of primary melanoma during the years 1983-1993 . The primary treatment of 15,054 patients with malignant melanoma and without recognizable metastasis has been examined . During the time period under investigation the percentage of cases treated with two-step surgical management increased from 30% to 60% . Primary excision was performed in local anaesthesia in 40% of all patients in 1983 , whereas in 1993 surgical intervention under local anaesthesia had increased up to 80% . Over the same time , the average safety margin decreased from 33 mm to 21 mm for the final excision of primary melanomas , and this decrease was paralleled by marked decrease in the average thickness of the tumours excised from 2.1 to 1.5 mm . Elective node dissection was performed in 5% of all patients in 1983 , whereas 9% of patients underwent elective node dissection in 1993. The different centres participating were found to differ noticeably in the therapeutic procedures applied for similar indications . In conclusion , the management of primary malignant melanoma has changed considerably during the years 1983-1993 in the German speaking area in favour of a two-step surgical procedure , local anaesthesia for the excision of the primary tumour and smaller safety margins . It seems that earlier diagnosis of the tumour and also ideas about treatment design may be responsible for these changes ."
],
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0,
1748
]
]
}
] |
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] |
DerHautarzt.50460771.eng.abstr
|
DerHautarzt.50460771.eng.abstr
|
[
{
"id": "DerHautarzt.50460771.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In the course of a cohort study addressing the importance of constitutional and occupational risk factors for the development of irritant hand eczema , 859 hairdressing apprentices were examined in 14 vocational training schools in autumn 1993 , after an average of 8 weeks of professional exposure . In this cross-sectional survey at the start of training , 38.2% were suffering from skin damage , in most cases mild to moderate and only rarely severe ; we observed almost exclusively irritant skin damage , mostly localized interdigitally . Logistic regression analysis revealed previous hand eczema , an elevated \" atopy score \" ( Diepgen ) and , particularly , unprotected work for several hours daily with wet hands as significant risk factors for this early onset irritant damage/eczema . The high wet workload is mainly caused by very frequent shampooing and by permanent waving without wearing gloves ; however , other tasks are also often performed without appropriate protective gloves . The implications of the considerable inter-observer variability are described and discussed ."
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DerHautarzt.50460785.eng.abstr
|
DerHautarzt.50460785.eng.abstr
|
[
{
"id": "DerHautarzt.50460785.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In a 22-year-old woman with mental impairment and some signs of dysmorphism , numerous angiokeratomas developed , starting when she was 3 years old and resulting in the clinical picture of angiokeratoma corporis diffusum . Extensive laboratory analyses did not disclose any associated metabolic disorder , and electron microscopy failed to demonstrate lysosomal inclusions . Therefore , this patient can be classified as one of the rare cases of angiokeratoma corporis diffusum without associated metabolic disease ( idiopathic angiokeratoma corporis diffusum ) ."
],
"offsets": [
[
0,
563
]
]
}
] |
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[] |
[] |
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] |
DerHautarzt.50460789.eng.abstr
|
DerHautarzt.50460789.eng.abstr
|
[
{
"id": "DerHautarzt.50460789.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Bullous pemphigoid ( BP ) is a bullous autoimmune disease of the elderly ; it is characterized by tense bullae on both erythematous and otherwise apparently normal skin . Several clinical variants of BP have been described , and we now add our observations of two BP cases mimicking subacute prurigo . Both patients had suffered from intensely pruritic excoriated papules for several months before presentation . Blisters had never developed and did not occur during follow up . Histology showed changes of chronic dermatitis . In the serum of both patients , indirect immunofluorescence on NaCl-separated human skin revealed the presence of circulating antibodies binding to the roof of the artificial blisters . Perilesional skin biopsies showed linear IgG or C3 deposits in the basement membran zone . Immunoblotting of epidermal and dermal extracts demonstrated the binding of the antibodies to an epidermal 230-kD protein , which is the known major bullous pemphigoid antigen . These cases are described as a basis for discussion of the clinical spectrum of bullous pemphigoid ."
],
"offsets": [
[
0,
1083
]
]
}
] |
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{
"id": "DerHautarzt.50460789.eng.abstr-s1-t2",
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"disease"
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},
{
"id": "DerHautarzt.50460789.eng.abstr-s1-t3",
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"elderly"
],
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},
{
"id": "DerHautarzt.50460789.eng.abstr-s1-t4",
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"bullae"
],
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104,
110
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"id": "DerHautarzt.50460789.eng.abstr-s1-t5",
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"skin"
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"Bullous pemphigoid"
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"id": "DerHautarzt.50460789.eng.abstr-s1-t7",
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{
"id": "DerHautarzt.50460789.eng.abstr-s2-t2",
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"prurigo"
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292,
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"id": "DerHautarzt.50460789.eng.abstr-s4-t1",
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"Blisters"
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"id": "DerHautarzt.50460789.eng.abstr-s5-t2",
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{
"id": "DerHautarzt.50460789.eng.abstr-s6-t2",
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"id": "DerHautarzt.50460789.eng.abstr-s6-t3",
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"id": "DerHautarzt.50460789.eng.abstr-s6-t6",
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"id": "DerHautarzt.50460789.eng.abstr-s6-t7",
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"id": "DerHautarzt.50460789.eng.abstr-s7-t2",
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] |
[] |
[] |
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DerHautarzt.50460796.eng.abstr
|
DerHautarzt.50460796.eng.abstr
|
[
{
"id": "DerHautarzt.50460796.eng.abstr-passage-0",
"type": "abstract",
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[] |
[] |
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] |
DerHautarzt.50460799.eng.abstr
|
DerHautarzt.50460799.eng.abstr
|
[
{
"id": "DerHautarzt.50460799.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 12-year-old girl from Zaire with Aids ( CDC : P2 D1) presented with a generalized molluscum contagiosum infection . She had suffered from systemic cryptococcosis and from cryptosporidiosis several months before admission . While molluscum contagiosum infection is usually a self-limiting disease in immunocompetent persons , a fulminant appearance and persistence of giant mollusca occurs with advanced immunodeficiency . Histological and immunohistological examinations showed a severe diminution of Langerhans and T cell populations that might enhance the dissemination of the infection . Molluscum-like lesions of cryptococci have been described , and cutaneous cryptococcosis is the main condition to be considered in the differential diagnosis . Further differential diagnoses should include American and African histoplasmosis , and the cutaneous manifestations of mycobacterial infections , of toxoplasmosis and of Pneumocystis carinii infection ."
],
"offsets": [
[
0,
956
]
]
}
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{
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},
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"id": "DerHautarzt.50460799.eng.abstr-s3-t5",
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{
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"id": "DerHautarzt.50460799.eng.abstr-s4-t1",
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[] |
[] |
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] |
DerHautarzt.50460804.eng.abstr
|
DerHautarzt.50460804.eng.abstr
|
[
{
"id": "DerHautarzt.50460804.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Tonsure trichotillomania is a subtype of trichotillomania in which the scalp exhibits a tonsural pattern of alopecia over the crown , extending to the frontal margin and sparing the lateral margins and the nape of the neck . It differs from to the more common form of childhood trichotillomania in that predominantly female adolescents are affected and its incidence is related to quite severely pathologic psychodynamics , often with a disturbed relationship to female sexuality . The treating physician should be more guarded in assessing the prognosis ; hair plucking often continues for years . Two patients with tonsure alopecia , associated in one case with trichotillomania of the pubic hair and in the other with enuresis , are presented ."
],
"offsets": [
[
0,
747
]
]
}
] |
[
{
"id": "DerHautarzt.50460804.eng.abstr-s1-t1",
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"text": [
"trichotillomania"
],
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[
8,
24
]
],
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"db_id": "C0040953"
}
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},
{
"id": "DerHautarzt.50460804.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"trichotillomania"
],
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[
41,
57
]
],
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{
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"db_id": "C0040953"
}
]
},
{
"id": "DerHautarzt.50460804.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"scalp"
],
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[
71,
76
]
],
"normalized": [
{
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"db_id": "C0036270"
}
]
},
{
"id": "DerHautarzt.50460804.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"tonsural"
],
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[
88,
96
]
],
"normalized": [
{
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"db_id": "C0626053"
}
]
},
{
"id": "DerHautarzt.50460804.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"alopecia"
],
"offsets": [
[
108,
116
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] |
DerHautarzt.50460831.eng.abstr
|
DerHautarzt.50460831.eng.abstr
|
[
{
"id": "DerHautarzt.50460831.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Human parvovirus B19 causes erythema infectiosum ( fifth disease ) and aplastic crisis . In pregnancy , B19 may be transmitted on to the fetus resulting in hydrops fetalis . B19 is sometimes associated with thrombocytopenia and vasculitis . In immunocompromised patients , B19 may persist causing chronic infection . Several methods for detecting B19 virus or specific antibodies are now available . B19 infection does not usually require therapy . Efficacy of immunoglobulins in chronic B19 infection has been demonstrated ."
],
"offsets": [
[
0,
525
]
]
}
] |
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"id": "DerHautarzt.50460831.eng.abstr-s2-t3",
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] |
[] |
[] |
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] |
DerHautarzt.50460836.eng.abstr
|
DerHautarzt.50460836.eng.abstr
|
[
{
"id": "DerHautarzt.50460836.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report on four patients with acquired ichthyosis-like skin lesions seen in our out-patients' clinic in the last 6 years . Emphasis is placed on the case of a 25-year-old patient who suffered from mycosis fungoides with the clinical features of an acquired ichthyosis-like condition . Three further observations illustrate the broad clinical spectrum of acquired ichthyosis-like dermatoses . In these patients renal insufficiency , HIV infection or an extreme diet were the cause of the skin lesions . Our observations emphasise that an acquired ichthyosis-like condition should be regarded as a challenge to make a definite diagnosis . Guidelines for a step-by-step diagnostic procedure are proposed ."
],
"offsets": [
[
0,
704
]
]
}
] |
[
{
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"patients"
],
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18,
26
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.50460836.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"ichthyosis-like"
],
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[
41,
56
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0020757"
}
]
},
{
"id": "DerHautarzt.50460836.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"skin"
],
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[
57,
61
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.50460836.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"patient"
],
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[
173,
180
]
],
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{
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}
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},
{
"id": "DerHautarzt.50460836.eng.abstr-s2-t2",
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"text": [
"mycosis"
],
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[
199,
206
]
],
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{
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"db_id": "C0026946"
}
]
},
{
"id": "DerHautarzt.50460836.eng.abstr-s2-t3",
"type": "umlsterm",
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"ichthyosis-like"
],
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[
259,
274
]
],
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{
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}
]
},
{
"id": "DerHautarzt.50460836.eng.abstr-s2-t4",
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"mycosis fungoides"
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[
199,
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]
],
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{
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[] |
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] |
DerHautarzt.50460841.eng.abstr
|
DerHautarzt.50460841.eng.abstr
|
[
{
"id": "DerHautarzt.50460841.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report a 31-year-old renal transplant patient treated with cyclosporin A who developed an unusual sebaceous gland hyperplasia accompanied by a disseminated follicular spiny hyperkeratosis . Those alterations were most evident on his face and limbs . In some locations hairy hyperkeratosis with authentic hair neogenesis was found . The histology of these alterations showed a marked hyperkeratosis of the hair follicles with formation of hair-like spikes either alone or in connection with hairs . The presence of true hairs distinguishes our case from the morphologically similar disseminated spiked hyperkeratosis and other spiny keratinization disorders . Scanning electron microscopy helped to demonstrate the hair-like structure of these keratoses . Some of the sebaceous glands showed cystic widening of their lumina , which were filled with abundant amorphous eosinophilic material , a finding similar to earlier observations . Our case demonstrates that these skin alterations should be classified as side effects of cyclosporin A and that they are apparently dose-dependent ."
],
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"arg1_id": "DerHautarzt.50460841.eng.abstr-s8-t2",
"arg2_id": "DerHautarzt.50460841.eng.abstr-s8-t3",
"normalized": []
},
{
"id": "DerHautarzt.50460841.eng.abstr-s8-r18-t2.2-t3.1",
"type": "diagnoses",
"arg1_id": "DerHautarzt.50460841.eng.abstr-s8-t2",
"arg2_id": "DerHautarzt.50460841.eng.abstr-s8-t3",
"normalized": []
},
{
"id": "DerHautarzt.50460841.eng.abstr-s8-r19-t3.1-t1.1",
"type": "disrupts",
"arg1_id": "DerHautarzt.50460841.eng.abstr-s8-t3",
"arg2_id": "DerHautarzt.50460841.eng.abstr-s8-t1",
"normalized": []
},
{
"id": "DerHautarzt.50460841.eng.abstr-s8-r21-t1.1-t2.2",
"type": "produces",
"arg1_id": "DerHautarzt.50460841.eng.abstr-s8-t1",
"arg2_id": "DerHautarzt.50460841.eng.abstr-s8-t2",
"normalized": []
},
{
"id": "DerHautarzt.50460841.eng.abstr-s8-r22-t2.1-t3.1",
"type": "treats",
"arg1_id": "DerHautarzt.50460841.eng.abstr-s8-t2",
"arg2_id": "DerHautarzt.50460841.eng.abstr-s8-t3",
"normalized": []
},
{
"id": "DerHautarzt.50460841.eng.abstr-s8-r23-t1.1-t3.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.50460841.eng.abstr-s8-t1",
"arg2_id": "DerHautarzt.50460841.eng.abstr-s8-t3",
"normalized": []
}
] |
DerHautarzt.50460847.eng.abstr
|
DerHautarzt.50460847.eng.abstr
|
[
{
"id": "DerHautarzt.50460847.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We present a 34-year-old woman with angioma serpiginosum on the medial aspect of the left thigh , extending to the groin and the lower abdomen , and on the volar aspect of the left forearm . In addition to the late onset , the distribution along the lines of Blaschko was a remarkable feature of this case . We therefore re-examined our recent cases of angioma serpiginosum . In 6 of 7 cases , the distribution indeed corresponded to the lines of Blaschko . Thus , we suggest adding angioma serpiginosum to the list of skin lesions that may follow the lines of Blaschko ."
],
"offsets": [
[
0,
571
]
]
}
] |
[
{
"id": "DerHautarzt.50460847.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"woman"
],
"offsets": [
[
25,
30
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0043210"
}
]
},
{
"id": "DerHautarzt.50460847.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"angioma"
],
"offsets": [
[
36,
43
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018916"
}
]
},
{
"id": "DerHautarzt.50460847.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"thigh"
],
"offsets": [
[
90,
95
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0039866"
}
]
},
{
"id": "DerHautarzt.50460847.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"groin"
],
"offsets": [
[
115,
120
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018246"
}
]
},
{
"id": "DerHautarzt.50460847.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"abdomen"
],
"offsets": [
[
135,
142
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0000726"
}
]
},
{
"id": "DerHautarzt.50460847.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"forearm"
],
"offsets": [
[
181,
188
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0016536"
}
]
},
{
"id": "DerHautarzt.50460847.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"distribution"
],
"offsets": [
[
227,
239
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0520511"
}
]
},
{
"id": "DerHautarzt.50460847.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"lines"
],
"offsets": [
[
250,
255
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0677502"
}
]
},
{
"id": "DerHautarzt.50460847.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"angioma"
],
"offsets": [
[
353,
360
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018916"
}
]
},
{
"id": "DerHautarzt.50460847.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"distribution"
],
"offsets": [
[
398,
410
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0520511"
}
]
},
{
"id": "DerHautarzt.50460847.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"lines"
],
"offsets": [
[
438,
443
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0677502"
}
]
},
{
"id": "DerHautarzt.50460847.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"angioma"
],
"offsets": [
[
483,
490
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018916"
}
]
},
{
"id": "DerHautarzt.50460847.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"skin"
],
"offsets": [
[
519,
523
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.50460847.eng.abstr-s5-t3",
"type": "umlsterm",
"text": [
"lines"
],
"offsets": [
[
552,
557
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0677502"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.50460847.eng.abstr-s1-r1-t2.1-t1.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.50460847.eng.abstr-s5-t2",
"arg2_id": "DerHautarzt.50460847.eng.abstr-s5-t1",
"normalized": []
},
{
"id": "DerHautarzt.50460847.eng.abstr-s1-r2-t1.1-t2.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.50460847.eng.abstr-s5-t1",
"arg2_id": "DerHautarzt.50460847.eng.abstr-s5-t2",
"normalized": []
},
{
"id": "DerHautarzt.50460847.eng.abstr-s5-r1-t2.1-t3.1",
"type": "produces",
"arg1_id": "DerHautarzt.50460847.eng.abstr-s5-t2",
"arg2_id": "DerHautarzt.50460847.eng.abstr-s5-t3",
"normalized": []
},
{
"id": "DerHautarzt.50460847.eng.abstr-s5-r2-t3.1-t1.1",
"type": "affects",
"arg1_id": "DerHautarzt.50460847.eng.abstr-s5-t3",
"arg2_id": "DerHautarzt.50460847.eng.abstr-s5-t1",
"normalized": []
},
{
"id": "DerHautarzt.50460847.eng.abstr-s5-r3-t2.1-t1.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.50460847.eng.abstr-s5-t2",
"arg2_id": "DerHautarzt.50460847.eng.abstr-s5-t1",
"normalized": []
},
{
"id": "DerHautarzt.50460847.eng.abstr-s5-r4-t2.1-t1.1",
"type": "location_of",
"arg1_id": "DerHautarzt.50460847.eng.abstr-s5-t2",
"arg2_id": "DerHautarzt.50460847.eng.abstr-s5-t1",
"normalized": []
},
{
"id": "DerHautarzt.50460847.eng.abstr-s5-r5-t1.1-t2.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.50460847.eng.abstr-s5-t1",
"arg2_id": "DerHautarzt.50460847.eng.abstr-s5-t2",
"normalized": []
}
] |
DerHautarzt.50460854.eng.abstr
|
DerHautarzt.50460854.eng.abstr
|
[
{
"id": "DerHautarzt.50460854.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Tinea capitis and corporis caused by Trichophyton soudanense were identified in a 6-year-old coloured boy who was born in Zaire and had been living for 3 years in Germany . This dermatophyte is very rarely seen outside the region in Africa where it is endemic . The disease is frequently overlooked at diagnosis because of the pathogen's capacity for causing chronic and oligosymptomatic infections . In our case the tinea did not a become apparent until the patient had been in Germany for 3 years . No-one else in his family had any comparable scalp or skin lesions . Consistent therapy with itraconazole ( Sempera ) dosed at 3 mg/kg body weight per day over a period of 4 weeks led to a permanent cure ."
],
"offsets": [
[
0,
706
]
]
}
] |
[
{
"id": "DerHautarzt.50460854.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"Tinea"
],
"offsets": [
[
0,
5
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0040247"
}
]
},
{
"id": "DerHautarzt.50460854.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"Trichophyton"
],
"offsets": [
[
37,
49
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0040933"
}
]
},
{
"id": "DerHautarzt.50460854.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"Zaire"
],
"offsets": [
[
122,
127
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0043444"
}
]
},
{
"id": "DerHautarzt.50460854.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"Germany"
],
"offsets": [
[
163,
170
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0017480"
}
]
},
{
"id": "DerHautarzt.50460854.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"Tinea capitis"
],
"offsets": [
[
0,
13
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0040250"
}
]
},
{
"id": "DerHautarzt.50460854.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"dermatophyte"
],
"offsets": [
[
178,
190
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011635"
}
]
},
{
"id": "DerHautarzt.50460854.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"Africa"
],
"offsets": [
[
233,
239
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0001737"
}
]
},
{
"id": "DerHautarzt.50460854.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"endemic"
],
"offsets": [
[
252,
259
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0243130"
}
]
},
{
"id": "DerHautarzt.50460854.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"disease"
],
"offsets": [
[
266,
273
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0012634"
}
]
},
{
"id": "DerHautarzt.50460854.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"diagnosis"
],
"offsets": [
[
302,
311
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0011900"
},
{
"db_name": "UMLS",
"db_id": "C0348026"
}
]
},
{
"id": "DerHautarzt.50460854.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"pathogen's"
],
"offsets": [
[
327,
337
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0605770"
}
]
},
{
"id": "DerHautarzt.50460854.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"infections"
],
"offsets": [
[
388,
398
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0021311"
}
]
},
{
"id": "DerHautarzt.50460854.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"tinea"
],
"offsets": [
[
417,
422
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0040247"
}
]
},
{
"id": "DerHautarzt.50460854.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"patient"
],
"offsets": [
[
459,
466
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.50460854.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"Germany"
],
"offsets": [
[
479,
486
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0017480"
}
]
},
{
"id": "DerHautarzt.50460854.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"family"
],
"offsets": [
[
520,
526
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0015576"
}
]
},
{
"id": "DerHautarzt.50460854.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"scalp"
],
"offsets": [
[
546,
551
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0036270"
}
]
},
{
"id": "DerHautarzt.50460854.eng.abstr-s5-t3",
"type": "umlsterm",
"text": [
"skin"
],
"offsets": [
[
555,
559
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.50460854.eng.abstr-s6-t1",
"type": "umlsterm",
"text": [
"therapy"
],
"offsets": [
[
581,
588
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0087111"
},
{
"db_name": "UMLS",
"db_id": "C0039798"
}
]
},
{
"id": "DerHautarzt.50460854.eng.abstr-s6-t2",
"type": "umlsterm",
"text": [
"itraconazole"
],
"offsets": [
[
594,
606
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0064113"
}
]
},
{
"id": "DerHautarzt.50460854.eng.abstr-s6-t3",
"type": "umlsterm",
"text": [
"weight"
],
"offsets": [
[
641,
647
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0005910"
},
{
"db_name": "UMLS",
"db_id": "C0043100"
}
]
},
{
"id": "DerHautarzt.50460854.eng.abstr-s6-t4",
"type": "umlsterm",
"text": [
"period"
],
"offsets": [
[
663,
669
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0025344"
}
]
},
{
"id": "DerHautarzt.50460854.eng.abstr-s6-t5",
"type": "umlsterm",
"text": [
"body weight"
],
"offsets": [
[
636,
647
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0005910"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.50460854.eng.abstr-s1-r1-t1.1-t2.1",
"type": "affects",
"arg1_id": "DerHautarzt.50460854.eng.abstr-s6-t1",
"arg2_id": "DerHautarzt.50460854.eng.abstr-s6-t2",
"normalized": []
},
{
"id": "DerHautarzt.50460854.eng.abstr-s1-r2-t2.1-t1.1",
"type": "causes",
"arg1_id": "DerHautarzt.50460854.eng.abstr-s6-t2",
"arg2_id": "DerHautarzt.50460854.eng.abstr-s6-t1",
"normalized": []
},
{
"id": "DerHautarzt.50460854.eng.abstr-s1-r3-t1.1-t5.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.50460854.eng.abstr-s6-t1",
"arg2_id": "DerHautarzt.50460854.eng.abstr-s6-t5",
"normalized": []
},
{
"id": "DerHautarzt.50460854.eng.abstr-s1-r4-t5.1-t3.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.50460854.eng.abstr-s6-t5",
"arg2_id": "DerHautarzt.50460854.eng.abstr-s6-t3",
"normalized": []
},
{
"id": "DerHautarzt.50460854.eng.abstr-s1-r5-t4.1-t5.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.50460854.eng.abstr-s6-t4",
"arg2_id": "DerHautarzt.50460854.eng.abstr-s6-t5",
"normalized": []
},
{
"id": "DerHautarzt.50460854.eng.abstr-s1-r6-t4.1-t1.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.50460854.eng.abstr-s6-t4",
"arg2_id": "DerHautarzt.50460854.eng.abstr-s6-t1",
"normalized": []
},
{
"id": "DerHautarzt.50460854.eng.abstr-s1-r7-t1.1-t4.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.50460854.eng.abstr-s6-t1",
"arg2_id": "DerHautarzt.50460854.eng.abstr-s6-t4",
"normalized": []
},
{
"id": "DerHautarzt.50460854.eng.abstr-s1-r8-t5.1-t2.1",
"type": "affects",
"arg1_id": "DerHautarzt.50460854.eng.abstr-s6-t5",
"arg2_id": "DerHautarzt.50460854.eng.abstr-s6-t2",
"normalized": []
},
{
"id": "DerHautarzt.50460854.eng.abstr-s1-r9-t2.1-t5.1",
"type": "causes",
"arg1_id": "DerHautarzt.50460854.eng.abstr-s6-t2",
"arg2_id": "DerHautarzt.50460854.eng.abstr-s6-t5",
"normalized": []
},
{
"id": "DerHautarzt.50460854.eng.abstr-s1-r10-t5.1-t1.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.50460854.eng.abstr-s6-t5",
"arg2_id": "DerHautarzt.50460854.eng.abstr-s6-t1",
"normalized": []
},
{
"id": "DerHautarzt.50460854.eng.abstr-s1-r11-t1.1-t3.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.50460854.eng.abstr-s6-t1",
"arg2_id": "DerHautarzt.50460854.eng.abstr-s6-t3",
"normalized": []
},
{
"id": "DerHautarzt.50460854.eng.abstr-s1-r12-t5.1-t4.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.50460854.eng.abstr-s6-t5",
"arg2_id": "DerHautarzt.50460854.eng.abstr-s6-t4",
"normalized": []
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] |
DerHautarzt.50460858.eng.abstr
|
DerHautarzt.50460858.eng.abstr
|
[
{
"id": "DerHautarzt.50460858.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Report on a 31-year-old male-tofemale transsexual prostitute with a 3-week history of worsening pruritus and dysaesthesia in her neovagina , which had been constructed by means of penile skin invagination . The microbial diagnostic tests for sexually transmitted diseases ( STD ) showed gonococcal infection in the high vagina , while none was found in the urethra . Other STD and allergic contact sensitization were excluded . Despite the regularly stratified epithelium of the neovagina , which is physiologically resistant to gonococcal infection , this possibility must be considered in transsexual prostitutes ."
],
"offsets": [
[
0,
616
]
]
}
] |
[
{
"id": "DerHautarzt.50460858.eng.abstr-s1-t1",
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"history"
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82
]
],
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}
]
},
{
"id": "DerHautarzt.50460858.eng.abstr-s1-t2",
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"text": [
"pruritus"
],
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96,
104
]
],
"normalized": [
{
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"db_id": "C0033778"
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}
]
},
{
"id": "DerHautarzt.50460858.eng.abstr-s1-t3",
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"text": [
"dysaesthesia"
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[
109,
121
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],
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{
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"db_id": "C0392699"
}
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},
{
"id": "DerHautarzt.50460858.eng.abstr-s1-t4",
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"text": [
"skin"
],
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[
187,
191
]
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{
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},
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"id": "DerHautarzt.50460858.eng.abstr-s2-t1",
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"diagnostic"
],
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221,
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]
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{
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}
]
},
{
"id": "DerHautarzt.50460858.eng.abstr-s2-t2",
"type": "umlsterm",
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"tests"
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[
232,
237
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],
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"db_id": "C0076174"
}
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},
{
"id": "DerHautarzt.50460858.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"diseases"
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{
"id": "DerHautarzt.50460858.eng.abstr-s2-t4",
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"text": [
"STD"
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]
},
{
"id": "DerHautarzt.50460858.eng.abstr-s2-t5",
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"text": [
"infection"
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[
298,
307
]
],
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"db_id": "C0021311"
}
]
},
{
"id": "DerHautarzt.50460858.eng.abstr-s2-t6",
"type": "umlsterm",
"text": [
"vagina"
],
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[
320,
326
]
],
"normalized": [
{
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"db_id": "C0042251"
},
{
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}
]
},
{
"id": "DerHautarzt.50460858.eng.abstr-s2-t7",
"type": "umlsterm",
"text": [
"urethra"
],
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357,
364
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],
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{
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},
{
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{
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"db_id": "C0153620"
}
]
},
{
"id": "DerHautarzt.50460858.eng.abstr-s2-t8",
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"diagnostic tests"
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221,
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},
{
"id": "DerHautarzt.50460858.eng.abstr-s2-t9",
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"gonococcal infection"
],
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287,
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]
},
{
"id": "DerHautarzt.50460858.eng.abstr-s2-t10",
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242,
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],
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},
{
"id": "DerHautarzt.50460858.eng.abstr-s3-t1",
"type": "umlsterm",
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"STD"
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]
},
{
"id": "DerHautarzt.50460858.eng.abstr-s4-t1",
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"text": [
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},
{
"id": "DerHautarzt.50460858.eng.abstr-s4-t2",
"type": "umlsterm",
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},
{
"id": "DerHautarzt.50460858.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"gonococcal infection"
],
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529,
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],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018081"
}
]
}
] |
[] |
[] |
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{
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] |
DerHautarzt.50460860.eng.abstr
|
DerHautarzt.50460860.eng.abstr
|
[
{
"id": "DerHautarzt.50460860.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We present , to the best of our knowledge , the first case of a malignant , primary plaque-type blue naevus in a 61-year-old male . Two biopsy specimens had been examined within 13 years , and revealed a common and cellular blue variant as a precursor . Locally invasive growth and regional lymph node swelling were present , but these alone could not confirm malignancy before evaluation of all clinical and histopathological features , as they are known to occur with benign cellular blue naevi . The recent literature and our case indicate that there is a malignant potential in every histological and clinical variant of blue naevus ."
],
"offsets": [
[
0,
638
]
]
}
] |
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]
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]
},
{
"id": "DerHautarzt.50460860.eng.abstr-s1-t4",
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"id": "DerHautarzt.50460860.eng.abstr-s1-t6",
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},
{
"id": "DerHautarzt.50460860.eng.abstr-s3-t2",
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DerHautarzt.50460865.eng.abstr
|
DerHautarzt.50460865.eng.abstr
|
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"Clear cell acanthoma is a rare , slow-growing benign epidermal tumour of adulthood . The predilection site of this usually solitary lesion is the distal part of the leg . Multiple clear cell acanthomas are very rare and are also found in other locations besides the typical site of predilection . In this paper we report on a 52-year-old man who - over a period of more than 20 years - had developed more than 100 of these tumours in all parts of his body . Although the histological diagnosis is easy , clinical recognition often proves difficult , especially in cases of multiple lesions . Different kinds of therapy for solitary and multiple lesions are discussed ."
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[] |
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] |
DerHautarzt.60470002.eng.abstr
|
DerHautarzt.60470002.eng.abstr
|
[
{
"id": "DerHautarzt.60470002.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The eyelids are the site of many different pathological conditions . Swelling - often oedematous - is a frequent symptom . This publication deals with the pathophysiological and anatomical basis of eyelid swelling and mainly provides a practical approach for differential diagnosis with the help of flow and short characterisations of possible causes . The subjective complaints of the patient charts ( pain , pruritus ) are shown to be important criteria for orientation . Special interest is focussed on allergic diseases and atrophic conditions as causes of eyelid swelling ."
],
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0,
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]
]
}
] |
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{
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"id": "DerHautarzt.60470002.eng.abstr-s3-t2",
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},
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},
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},
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"id": "DerHautarzt.60470002.eng.abstr-s3-t6",
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}
]
},
{
"id": "DerHautarzt.60470002.eng.abstr-s4-t2",
"type": "umlsterm",
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"pain"
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}
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},
{
"id": "DerHautarzt.60470002.eng.abstr-s4-t3",
"type": "umlsterm",
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]
},
{
"id": "DerHautarzt.60470002.eng.abstr-s4-t4",
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},
{
"id": "DerHautarzt.60470002.eng.abstr-s4-t5",
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},
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"id": "DerHautarzt.60470002.eng.abstr-s5-t1",
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},
{
"id": "DerHautarzt.60470002.eng.abstr-s5-t2",
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]
},
{
"id": "DerHautarzt.60470002.eng.abstr-s5-t3",
"type": "umlsterm",
"text": [
"eyelid"
],
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561,
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],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0015426"
}
]
}
] |
[] |
[] |
[
{
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},
{
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"type": "location_of",
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},
{
"id": "DerHautarzt.60470002.eng.abstr-s3-r4-t2.1-t4.1",
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},
{
"id": "DerHautarzt.60470002.eng.abstr-s3-r5-t1.1-t4.2",
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},
{
"id": "DerHautarzt.60470002.eng.abstr-s4-r1-t3.1-t4.1",
"type": "evaluation_of",
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{
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},
{
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},
{
"id": "DerHautarzt.60470002.eng.abstr-s4-r7-t2.1-t4.1",
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},
{
"id": "DerHautarzt.60470002.eng.abstr-s4-r8-t3.1-t1.1",
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{
"id": "DerHautarzt.60470002.eng.abstr-s4-r9-t3.2-t3.1",
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},
{
"id": "DerHautarzt.60470002.eng.abstr-s4-r10-t3.1-t3.2",
"type": "associated_with",
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"arg2_id": "DerHautarzt.60470002.eng.abstr-s4-t3",
"normalized": []
},
{
"id": "DerHautarzt.60470002.eng.abstr-s5-r1-t2.1-t1.1",
"type": "location_of",
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"arg2_id": "DerHautarzt.60470002.eng.abstr-s5-t1",
"normalized": []
}
] |
DerHautarzt.60470020.eng.abstr
|
DerHautarzt.60470020.eng.abstr
|
[
{
"id": "DerHautarzt.60470020.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In a multicenter study , 100 patients with chronic urticaria were examined with a standardized personality test ( Giessen test ) , a standardized symptom questionnaire ( Giessener Beschwerdebogen ) and a specially developed questionnaire concerning symptoms , history and behaviour during symptomatic periods . Almost one third of the patients showed elevated scores both for depression and for symptoms that are often associated with depression . It therefore seems worthwhile examining such persons more specifically and possibly treating them by psychosomatic methods . The present results do not allow the classification of chronic urticaria as a somatization disorder . Since one-third of the patients had symptoms of depression , combined dermatological and psychosomatic approach may make it possible to offer them an appropriately targeted treatment ."
],
"offsets": [
[
0,
859
]
]
}
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{
"id": "DerHautarzt.60470020.eng.abstr-s1-t1",
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},
{
"id": "DerHautarzt.60470020.eng.abstr-s1-t2",
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{
"id": "DerHautarzt.60470020.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"personality"
],
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{
"id": "DerHautarzt.60470020.eng.abstr-s1-t4",
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},
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"type": "umlsterm",
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"id": "DerHautarzt.60470020.eng.abstr-s1-t9",
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},
{
"id": "DerHautarzt.60470020.eng.abstr-s1-t10",
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},
{
"id": "DerHautarzt.60470020.eng.abstr-s1-t11",
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}
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},
{
"id": "DerHautarzt.60470020.eng.abstr-s1-t12",
"type": "umlsterm",
"text": [
"periods"
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},
{
"id": "DerHautarzt.60470020.eng.abstr-s1-t13",
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},
{
"id": "DerHautarzt.60470020.eng.abstr-s1-t14",
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{
"id": "DerHautarzt.60470020.eng.abstr-s2-t1",
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}
]
},
{
"id": "DerHautarzt.60470020.eng.abstr-s2-t2",
"type": "umlsterm",
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},
{
"id": "DerHautarzt.60470020.eng.abstr-s2-t3",
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},
{
"id": "DerHautarzt.60470020.eng.abstr-s2-t4",
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},
{
"id": "DerHautarzt.60470020.eng.abstr-s3-t1",
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},
{
"id": "DerHautarzt.60470020.eng.abstr-s3-t2",
"type": "umlsterm",
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]
},
{
"id": "DerHautarzt.60470020.eng.abstr-s4-t1",
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},
{
"id": "DerHautarzt.60470020.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
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},
{
"id": "DerHautarzt.60470020.eng.abstr-s4-t3",
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},
{
"id": "DerHautarzt.60470020.eng.abstr-s4-t4",
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},
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},
{
"id": "DerHautarzt.60470020.eng.abstr-s5-t2",
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},
{
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DerHautarzt.60470024.eng.abstr
|
DerHautarzt.60470024.eng.abstr
|
[
{
"id": "DerHautarzt.60470024.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Sézary syndrome is the leukemic and erythrodermic form of cutaneous T-cell lymphoma ( CTCL ) . Since 1987 extracorporeal photochemotherapy ( ECP ) has been available for treatment of erythrodermic CTCL in the USA . Through a group of case reports , we want to emphasize ECP as the treatment of choice for erythrodermic CTCL ."
],
"offsets": [
[
0,
325
]
]
}
] |
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],
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],
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],
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68,
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{
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"id": "DerHautarzt.60470024.eng.abstr-s2-t3",
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106,
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DerHautarzt.60470029.eng.abstr
|
DerHautarzt.60470029.eng.abstr
|
[
{
"id": "DerHautarzt.60470029.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The role of elective lymph node dissection ( ELND ) in primary malignant melanoma is controversial . Our purpose was to evaluate the benefit of ELND regarding survival and disease-free survival in malignant melanoma of the trunk and extremities . By matched-pair analysis , 375 patients treated by wide local excision ( WLE ) plus ELND were compared to 375 patients treated by WLE only . There was no difference in survival between the two treatment groups ; however , the disease-free interval was significantly higher in the collective treated by WLE plus ELND ( P 0.05 ) . Increased survival rates were noted for intermediate tumor thickness of 1.51-4.0 mm for the WLE+ELND group although the difference was not significant ( P=0.14), and disease-free survival was significantly improved in this group ( P 0.001 ) . ELND elicited a higher benefit in male patients with intermediate thickness melanoma . Our results confirm the findings of several studies that ELND improves the outcome after primary treament of malignant melanoma of intermediate tumor thickness ."
],
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] |
[] |
[] |
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] |
DerHautarzt.60470035.eng.abstr
|
DerHautarzt.60470035.eng.abstr
|
[
{
"id": "DerHautarzt.60470035.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The median survival time for patients with disseminated malignant melanoma is 5-7 months ; it is still not really known whether therapeutic measures prolong survival . The aim of the present investigation was to identify patients with prolonged survival in stage IV disease and to analyse the possible impact of therapy on the course of the disease . in the Department of Dermatology , Benjamin Franklin University Medical Centre at the Free University of Berlin , 263 patients with were diagnosed as having stage IV melanoma and enrolled in a computer-based registry between 1970 and 1993. In 89 cases systemic medical mentous treatment was given and 111 patients underwent surgery and/or radiation therapy . There were 48 patients who received both systemic and local therapy . On the other hand , 111 patients received no treatment . Twenty two patients were identified survived longer than 24 months ( median survival time 33 months ) . None of the patients who had received no treatment survived for 2 years or longer . The 22 patients with prolonged survival were treated by multimodality included 16 who had received both systemic treatment and surgery and/or radiation , while 3 had had only systemic drug therapy and another 3 , only local treatment . Twelve of the 22 patients became tumour free after their initial surgery or radiation . Active therapy in disseminated melanoma with reduction of tumour mass by surgery and radiation and with systemic medical treatment may lead to prolonged survival in a considerable percentage of patients ."
],
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0,
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DerHautarzt.60470047.eng.abstr
|
DerHautarzt.60470047.eng.abstr
|
[
{
"id": "DerHautarzt.60470047.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We are presenting a 47-year-old woman who was stung by jellyfish while bathing in the sea of Thailand . Immediately after the injury she developed sharp pain and urticarial erythema of the skin of the knees accompanied by muscle cramps of the entire body . After a few days a toxic contact dermatitis with edematous swelling and ulcerations developed , which did not respond to topical antibiotics or corticosteroids . Three weeks later the patient presented with a disseminated urticarial eruption , which at first responded well to topical treatment and systemic corticosteroids . Over the next few weeks , however , a relapse of the eruption and the ulcerations occurred . Raised titres of IgG and IgM antibodies against different jellyfish from the Indian and Pacific Ocean were detected in the patient's serum by the enzyme-linked immunosorbent assay . Antibodies against bees ( class 1 ) and wasps ( class 4 ) were found by the radioallergosorbent test . The clinical features and the immunological findings led to the diagnosis of toxic and allergic contact dermatitis to jellyfish venom . First aid and secondary treatment of jellyfish injuries are suggested ."
],
"offsets": [
[
0,
1168
]
]
}
] |
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"id": "DerHautarzt.60470047.eng.abstr-s1-t1",
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"woman"
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32,
37
]
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}
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{
"id": "DerHautarzt.60470047.eng.abstr-s1-t2",
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"text": [
"jellyfish"
],
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"db_id": "C0022381"
}
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},
{
"id": "DerHautarzt.60470047.eng.abstr-s1-t3",
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"text": [
"bathing"
],
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]
],
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{
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"sea"
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"id": "DerHautarzt.60470047.eng.abstr-s2-t2",
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{
"id": "DerHautarzt.60470047.eng.abstr-s2-t3",
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"erythema"
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}
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},
{
"id": "DerHautarzt.60470047.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"skin"
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189,
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},
{
"id": "DerHautarzt.60470047.eng.abstr-s2-t5",
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"knees"
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{
"id": "DerHautarzt.60470047.eng.abstr-s2-t8",
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},
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},
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},
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},
{
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},
{
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},
{
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},
{
"id": "DerHautarzt.60470047.eng.abstr-s9-r7-t2.2-t1.2",
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}
] |
DerHautarzt.60470053.eng.abstr
|
DerHautarzt.60470053.eng.abstr
|
[
{
"id": "DerHautarzt.60470053.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report on a 56-year-old male patient with annular , erythematous and slightly elevated lesions measuring up to 12 cm in diameter on the trunk . Histologically a diffuse mononuclear infiltrate with histiocytic giant cells was present . His condition is a rare variant of generalized granuloma annulare in association with diabetes mellitus ."
],
"offsets": [
[
0,
343
]
]
}
] |
[
{
"id": "DerHautarzt.60470053.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"male"
],
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[
27,
31
]
],
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"db_id": "C0024554"
},
{
"db_name": "UMLS",
"db_id": "C0086582"
}
]
},
{
"id": "DerHautarzt.60470053.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"patient"
],
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[
32,
39
]
],
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{
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"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.60470053.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"giant"
],
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[
212,
217
]
],
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"db_id": "C0017547"
}
]
},
{
"id": "DerHautarzt.60470053.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"cells"
],
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[
218,
223
]
],
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{
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"db_id": "C0007634"
}
]
},
{
"id": "DerHautarzt.60470053.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"giant cells"
],
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[
212,
223
]
],
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{
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"db_id": "C0017526"
}
]
},
{
"id": "DerHautarzt.60470053.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"granuloma"
],
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[
285,
294
]
],
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"db_id": "C0018188"
}
]
},
{
"id": "DerHautarzt.60470053.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"association"
],
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[
307,
318
]
],
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{
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"db_id": "C0004083"
}
]
},
{
"id": "DerHautarzt.60470053.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"diabetes"
],
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324,
332
]
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"db_id": "C0011847"
},
{
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}
]
},
{
"id": "DerHautarzt.60470053.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"granuloma annulare"
],
"offsets": [
[
285,
303
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0085074"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.60470053.eng.abstr-s1-r1-t1.1-t1.2",
"type": "interacts_with",
"arg1_id": "DerHautarzt.60470053.eng.abstr-s3-t1",
"arg2_id": "DerHautarzt.60470053.eng.abstr-s1-t1",
"normalized": []
},
{
"id": "DerHautarzt.60470053.eng.abstr-s1-r2-t1.2-t1.1",
"type": "interacts_with",
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"arg2_id": "DerHautarzt.60470053.eng.abstr-s3-t1",
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},
{
"id": "DerHautarzt.60470053.eng.abstr-s2-r1-t3.1-t1.1",
"type": "location_of",
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"arg2_id": "DerHautarzt.60470053.eng.abstr-s3-t1",
"normalized": []
},
{
"id": "DerHautarzt.60470053.eng.abstr-s2-r2-t2.1-t1.1",
"type": "location_of",
"arg1_id": "DerHautarzt.60470053.eng.abstr-s3-t2",
"arg2_id": "DerHautarzt.60470053.eng.abstr-s3-t1",
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},
{
"id": "DerHautarzt.60470053.eng.abstr-s3-r1-t2.1-t4.1",
"type": "result_of",
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},
{
"id": "DerHautarzt.60470053.eng.abstr-s3-r2-t2.1-t3.1",
"type": "result_of",
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},
{
"id": "DerHautarzt.60470053.eng.abstr-s3-r3-t2.1-t1.1",
"type": "result_of",
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},
{
"id": "DerHautarzt.60470053.eng.abstr-s3-r4-t1.1-t2.1",
"type": "result_of",
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},
{
"id": "DerHautarzt.60470053.eng.abstr-s3-r5-t1.1-t4.1",
"type": "degree_of",
"arg1_id": "DerHautarzt.60470053.eng.abstr-s3-t1",
"arg2_id": "DerHautarzt.60470053.eng.abstr-s3-t4",
"normalized": []
},
{
"id": "DerHautarzt.60470053.eng.abstr-s3-r6-t1.1-t3.1",
"type": "degree_of",
"arg1_id": "DerHautarzt.60470053.eng.abstr-s3-t1",
"arg2_id": "DerHautarzt.60470053.eng.abstr-s3-t3",
"normalized": []
}
] |
DerHautarzt.60470058.eng.abstr
|
DerHautarzt.60470058.eng.abstr
|
[
{
"id": "DerHautarzt.60470058.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A HIV-infected patient in stage CDC 3A with porphyria cutanea tarda ( type I ) was treated with chloroquin for some months and this led to full remission . The patient course is compared with earlier reports on HIV-infected patients with porphyria cutanea tarda . Possible provocation factors for porphyria cutanea tarda in HIV infection are considered . The increased prevalence of porphyria cutanea tarda in HIV infection , the interaction of HIV and UV irradiation as a prediposing factor for porphyria cutanea tarda and the photosensitivity present in HIV infection are discussed ."
],
"offsets": [
[
0,
585
]
]
}
] |
[
{
"id": "DerHautarzt.60470058.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"patient"
],
"offsets": [
[
15,
22
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.60470058.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"stage"
],
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[
26,
31
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027646"
}
]
},
{
"id": "DerHautarzt.60470058.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"CDC"
],
"offsets": [
[
32,
35
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0007670"
}
]
},
{
"id": "DerHautarzt.60470058.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"porphyria"
],
"offsets": [
[
44,
53
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0032708"
}
]
},
{
"id": "DerHautarzt.60470058.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"porphyria cutanea tarda"
],
"offsets": [
[
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DerHautarzt.60470091.eng.abstr
|
DerHautarzt.60470091.eng.abstr
|
[
{
"id": "DerHautarzt.60470091.eng.abstr-passage-0",
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"The epidemiology of AIDS-associated Kaposi's sarcoma ( KS ) points to a sexually transmittable disease . Despite the fact that a recently discovered new herpesvirus has been detected in all forms of KS ( Aids , classic , african and immunosuppressed - KS ) its role remains to be further established , since a simple infection cannot account for all epidemiologic findings in KS . Various cytokines seem to play an important role also . The effect of human chorionic gonadotropin on KS can explain the different incidence of KS in males and females . Whether all forms of KS indeed have common causes , today , seems doubtful ."
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]
}
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[] |
[] |
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DerHautarzt.60470096.eng.abstr
|
DerHautarzt.60470096.eng.abstr
|
[
{
"id": "DerHautarzt.60470096.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Besides the classical forms of cutaneous T-cell lymphoma ( C-CTCL ) , such as mycosis fungoides and Sézary's syndrome , unique variants may be encountered . The classification of these rare cutaneous T cell lymphomas is problematic and controversial . Newer classifications of lymphoma in general , such as the Revised European-American Lymphoma ( REAL ) Classification , emphasize well-established clinico-pathological entities . It seems appropriate to attempt to bring greater clarity to the classification of cutaneous T-cell lymphomas using the same principles . In this review , we list and characterize the rare variants of cutaneous T-cell lymphoma , such as ( 1 ) clinical , histological and immunological variants of mycosis fungoides ; ( 2 ) progressive cutaneous T-cell lymphoma ( P-CTCL ) including transformed classical cutaneous T-cell lymphoma ( TC-CTCL ) and primary progressive cutaneous T-cell lymphoma ( PP-CTCL ) ; ( 3 ) angiocentric and angioimmunoblastic cutaneous T-cell lymphomas ; ( 4 ) large cell anaplastic , CD30+ cutaneous T-cell lymphoma ; ( 5 ) HTLV-Iassociated adult T-cell leukemia/lymphoma ( ATLL ) ; ( 6 ) cutaneous manifestations of primary extracutaneous T-cell neoplasias ; ( 7 ) unclassifiable cutaneous T-cell lymphoma ."
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] |
[] |
[] |
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DerHautarzt.60470106.eng.abstr
|
DerHautarzt.60470106.eng.abstr
|
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"id": "DerHautarzt.60470106.eng.abstr-passage-0",
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"text": [
"In spite of its high incidence , not much is known about the etiology of chronic urticaria . We performed gastroscopic evaluation of 10 patients in whom no cause for chronic urticaria had been found . In 8 of these 10 patients , Helicobacter pylori was identified in the gastric mucosa . The chronic urticarial lesions disappeared within a few days after starting therapy with amoxicillin and omeprazol ."
],
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[
0,
404
]
]
}
] |
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"gastric mucosa"
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{
"id": "DerHautarzt.60470106.eng.abstr-s4-t2",
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}
] |
[] |
[] |
[
{
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{
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},
{
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},
{
"id": "DerHautarzt.60470106.eng.abstr-s3-r4-t3.1-t2.1",
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},
{
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},
{
"id": "DerHautarzt.60470106.eng.abstr-s3-r6-t6.1-t5.1",
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},
{
"id": "DerHautarzt.60470106.eng.abstr-s3-r7-t6.1-t3.1",
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},
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"id": "DerHautarzt.60470106.eng.abstr-s3-r9-t6.1-t2.1",
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},
{
"id": "DerHautarzt.60470106.eng.abstr-s3-r10-t4.1-t2.1",
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"normalized": []
}
] |
DerHautarzt.60470109.eng.abstr
|
DerHautarzt.60470109.eng.abstr
|
[
{
"id": "DerHautarzt.60470109.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The utility of two different epiluminescence microscopy rating protocols were tested prospectively and retrospectively on a group of 115 photographically documented naevi . Initially all naevi were classified histologically as dysplastic . While the first score table was set up only to identify dysplastic naevi , the second system lent itself to the differential diagnosis of malignant melanoma . Using this second scoring table 3 lesions were identified as melanomas directly and in 3 further melanomas the suspicion of dysplasia was confirmed . Malignancy was definitely confirmed only by histology . With regard to the surface microscopic differentiation of melanocytic lesions , the term \" dysplasia \" should not be abandoned . If the diagnosis of melanocytic tumours is problematic a double check of the clinical photograph using specific criteria cougled with histological evaluation appears helpful ."
],
"offsets": [
[
0,
909
]
]
}
] |
[
{
"id": "DerHautarzt.60470109.eng.abstr-s1-t1",
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"microscopy"
],
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45,
55
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]
},
{
"id": "DerHautarzt.60470109.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"naevi"
],
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165,
170
]
],
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},
{
"id": "DerHautarzt.60470109.eng.abstr-s2-t1",
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"text": [
"naevi"
],
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187,
192
]
],
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}
]
},
{
"id": "DerHautarzt.60470109.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"naevi"
],
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307,
312
]
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}
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{
"id": "DerHautarzt.60470109.eng.abstr-s3-t2",
"type": "umlsterm",
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"diagnosis"
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}
]
},
{
"id": "DerHautarzt.60470109.eng.abstr-s3-t3",
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"malignant"
],
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378,
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{
"id": "DerHautarzt.60470109.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"melanoma"
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388,
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"id": "DerHautarzt.60470109.eng.abstr-s3-t5",
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296,
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{
"id": "DerHautarzt.60470109.eng.abstr-s3-t6",
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"differential diagnosis"
],
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352,
374
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],
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"db_id": "C0220820"
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}
]
},
{
"id": "DerHautarzt.60470109.eng.abstr-s3-t7",
"type": "umlsterm",
"text": [
"malignant melanoma"
],
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378,
396
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},
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"id": "DerHautarzt.60470109.eng.abstr-s4-t1",
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"melanomas"
],
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460,
469
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{
"id": "DerHautarzt.60470109.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"melanomas"
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496,
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},
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"id": "DerHautarzt.60470109.eng.abstr-s5-t1",
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549,
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{
"id": "DerHautarzt.60470109.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
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]
},
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"id": "DerHautarzt.60470109.eng.abstr-s7-t1",
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]
},
{
"id": "DerHautarzt.60470109.eng.abstr-s7-t2",
"type": "umlsterm",
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},
{
"id": "DerHautarzt.60470109.eng.abstr-s7-t3",
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{
"id": "DerHautarzt.60470109.eng.abstr-s7-t4",
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"text": [
"evaluation"
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881,
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"normalized": [
{
"db_name": "UMLS",
"db_id": "C0220825"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.60470109.eng.abstr-s1-r1-t2.1-t1.1",
"type": "associated_with",
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{
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},
{
"id": "DerHautarzt.60470109.eng.abstr-s3-r1-t2.1-t7.1",
"type": "associated_with",
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"normalized": []
},
{
"id": "DerHautarzt.60470109.eng.abstr-s3-r2-t5.1-t7.1",
"type": "associated_with",
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},
{
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{
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},
{
"id": "DerHautarzt.60470109.eng.abstr-s3-r5-t5.1-t2.2",
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{
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},
{
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},
{
"id": "DerHautarzt.60470109.eng.abstr-s3-r8-t2.1-t1.1",
"type": "associated_with",
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"normalized": []
},
{
"id": "DerHautarzt.60470109.eng.abstr-s3-r9-t5.1-t1.1",
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},
{
"id": "DerHautarzt.60470109.eng.abstr-s5-r1-t2.2-t1.1",
"type": "issue_in",
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"normalized": []
},
{
"id": "DerHautarzt.60470109.eng.abstr-s7-r1-t3.1-t4.1",
"type": "evaluation_of",
"arg1_id": "DerHautarzt.60470109.eng.abstr-s7-t3",
"arg2_id": "DerHautarzt.60470109.eng.abstr-s7-t4",
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},
{
"id": "DerHautarzt.60470109.eng.abstr-s7-r2-t1.2-t4.1",
"type": "associated_with",
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"normalized": []
},
{
"id": "DerHautarzt.60470109.eng.abstr-s7-r5-t4.1-t1.1",
"type": "conceptual_part_of",
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"arg2_id": "DerHautarzt.60470109.eng.abstr-s7-t1",
"normalized": []
},
{
"id": "DerHautarzt.60470109.eng.abstr-s7-r6-t3.1-t1.1",
"type": "evaluation_of",
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"arg2_id": "DerHautarzt.60470109.eng.abstr-s7-t1",
"normalized": []
},
{
"id": "DerHautarzt.60470109.eng.abstr-s7-r7-t4.1-t1.2",
"type": "associated_with",
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"arg2_id": "DerHautarzt.60470109.eng.abstr-s7-t1",
"normalized": []
}
] |
DerHautarzt.60470114.eng.abstr
|
DerHautarzt.60470114.eng.abstr
|
[
{
"id": "DerHautarzt.60470114.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Extracorporeal photophoresis ( ECP ) , a therapeutic modality that has been under investigation for some years , is based on separation of a leucocyte/lymphocyte-enriched cell fraction from the peripheral blood , extracorporeal treatment of the cells with 8-MOP/UVA and subsequent reinfusion of the cells in the patient . Its main effects seem to consist in changes to the immunologic behaviour of the photoinactivated/modulated cells . The immune response of the host is obviously stimulated by this treatment . ECP is normally performed for 4 h per day on 2 consecutive days every 4 weeks . The treatment is well tolerated and causes few side effects . In our department , 1210 ECP treatments were administered to 41 patients between 1990 and 1994 and a preliminary evaluation was performed . These patients included 21 with cutaneous T-cell lymphoma ( CTCL ) , 10 with progressive systemic scleroderma , 4 with chronic graft-versus-host disease and 1 each with pemphigus vulgaris , epidermolysis bullosa acquisita , lupus erythematosus and cutaneous mucinosis . Patients with erythroderma and preserved immunocompetence achieved the best responses of all patients with CTCL . A treatment combining ECP with rlFN- , PUVA and/or radiation was also successful in patients with tumour-stage CTCL and lymph node involvement . Progressive systemic scleroderma responded in more than 50% of our cases . Treatment results were impressive in 4 patients with chronic graft-versus-host disease presenting with sclerodermatous and lichenoid changes of the skin and mucous membranes . A clear improvement was also observed in the patient with pemphigus vulgaris refractory to standard therapies and in another patient with scleromyxoedema ( Arndt-Gottron syndrome ) . The effectiveness of ECP seems to be quite well established in CTCL , but remains to be examined in autoimmune dermatoses . ECP is an attractive addition to the dermatological therapies available but our experience is still preliminary ."
],
"offsets": [
[
0,
1995
]
]
}
] |
[
{
"id": "DerHautarzt.60470114.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"photophoresis"
],
"offsets": [
[
15,
28
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0031740"
},
{
"db_name": "UMLS",
"db_id": "C0031765"
}
]
},
{
"id": "DerHautarzt.60470114.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"therapeutic"
],
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[
41,
52
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0039796"
}
]
},
{
"id": "DerHautarzt.60470114.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"separation"
],
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[
125,
135
]
],
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{
"db_name": "UMLS",
"db_id": "C0237868"
}
]
},
{
"id": "DerHautarzt.60470114.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"cell"
],
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[
171,
175
]
],
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{
"db_name": "UMLS",
"db_id": "C0007634"
}
]
},
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] |
[] |
[] |
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] |
DerHautarzt.60470124.eng.abstr
|
DerHautarzt.60470124.eng.abstr
|
[
{
"id": "DerHautarzt.60470124.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In recent years , interferon- has become widely used for systemic therapy of tumours and infectious diseases . Well-known cutaneous side effects include dry skin , pruritus and hair loss . Since 1986 , 17 patients with renal cell carcinoma , malignant melanoma , hepatitis B and C , carcinoid syndrome and hairy cell leukemia have been reported in whom psoriasis with or without psoriatic B joint involvement was induced or exacerbated by systemic interferon- therapy . In these patients , the drug was discontinued because of the severity of the psoriatic symptoms induced . The psoriatic lesions then resolved in nearly all patients within 2 weeks to 6 months , but in 10 of 22 patients treated with interferon- specifically for psoriasis exacerbation was reported . We report three new cases of interferon--induced psoriasis . The patients were treated with the drug for HIV-associated Kaposi's sarcoma , renal cell carcinoma , and hepatitis C. We conclude that interferon- can provoke psoriatic skin and joint symptoms , especially when additional precipitating factors are involved . In patients in whom such risks are present careful consideration of the benefit/risk ratio and concomitant antipsoriatic treatment are essential if interferon- therapy is to be continued ."
],
"offsets": [
[
0,
1277
]
]
}
] |
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{
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[] |
[] |
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] |
DerHautarzt.60470132.eng.abstr
|
DerHautarzt.60470132.eng.abstr
|
[
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"id": "DerHautarzt.60470132.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Therapy of pyoderma gangrenosum can be complicated by side effects of the various systemic therapies , including corticosteroids , azathioprin and cyclosporin A. In this paper we report on a 49-year-old patient presenting with recalcitrant pyoderma gangrenosum who was treated successfully by topical application of cyclosporin A. Cyclosporin A serum levels were always in the subtherapeutic range , and no side effects were observed ."
],
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[
0,
435
]
]
}
] |
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"id": "DerHautarzt.60470132.eng.abstr-s1-t10",
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}
] |
[] |
[] |
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] |
DerHautarzt.60470136.eng.abstr
|
DerHautarzt.60470136.eng.abstr
|
[
{
"id": "DerHautarzt.60470136.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report on a 32-year-old male patient with advanced acquired immunodeficiency syndrome ( AIDS ) , who had severe candidiasis of the gastrointestinal tract . Treatment with fluconazole , 200 mg/day , was introduced . After oral intake of fluconazole over 5 months itraconazole 200 mg/day was given for 1 month . However , fungal infection still persisted . The antifungal activity of fluconazole , itraconazole and ketoconazole against Candida albicans was evaluated by means of the microdilution test by determining the 90% inhibitory concentrations of each drugs . A high minimal inhibitory concentration ( MIC ) was detected for fluconazole ( 50 µg/ml) revealing fluconazole resistance . The susceptibility to itraconazole was borderline ( MIC 0.125 µg/ml) and that to ketoconazole was markedly lowered ( MIC 0.25 µg/ml). Plasma levels of itraconazole were also found to be lowered . In HIV patients the gastrointestinal absorption of azole derivatives is often reduced . Therefore , the clinical resistance of Candida albicans to itraconazole can be explained by reduced susceptibility after azole therapy and also by the decreased absorption of the drug in HIV patients ."
],
"offsets": [
[
0,
1177
]
]
}
] |
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] |
DerHautarzt.60470169.eng.abstr
|
DerHautarzt.60470169.eng.abstr
|
[
{
"id": "DerHautarzt.60470169.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Adhesion molecules are cell surface proteins responsible for cell-cell and cell-matrix interactions . They represent a basis for physiologic and pathologic processes , especially for homing behavior , homeostasis of the immune response , inflammations and tumor metastasis . Recently , adhesions molecules such as CD44v6 have been shown to be expressed on tumor cells of cutaneous lymphomas with systemic tumor spread and thus play an important role in metastasis ."
],
"offsets": [
[
0,
465
]
]
}
] |
[
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"Adhesion"
],
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0,
8
]
],
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},
{
"id": "DerHautarzt.60470169.eng.abstr-s1-t2",
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"cell"
],
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]
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}
]
},
{
"id": "DerHautarzt.60470169.eng.abstr-s1-t3",
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"proteins"
],
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]
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}
]
},
{
"id": "DerHautarzt.60470169.eng.abstr-s1-t4",
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"cell-cell"
],
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],
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},
{
"id": "DerHautarzt.60470169.eng.abstr-s1-t5",
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"cell-cell"
],
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},
{
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"cell-matrix"
],
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},
{
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"interactions"
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},
{
"id": "DerHautarzt.60470169.eng.abstr-s1-t8",
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"Adhesion molecules"
],
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},
{
"id": "DerHautarzt.60470169.eng.abstr-s1-t9",
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"surface proteins"
],
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},
{
"id": "DerHautarzt.60470169.eng.abstr-s1-t10",
"type": "umlsterm",
"text": [
"cell surface proteins"
],
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[
23,
44
]
],
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{
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"db_id": "C0242392"
}
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},
{
"id": "DerHautarzt.60470169.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"pathologic"
],
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145,
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]
],
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{
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]
},
{
"id": "DerHautarzt.60470169.eng.abstr-s2-t2",
"type": "umlsterm",
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"behavior"
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[
190,
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]
],
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},
{
"id": "DerHautarzt.60470169.eng.abstr-s2-t3",
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"homeostasis"
],
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},
{
"id": "DerHautarzt.60470169.eng.abstr-s2-t4",
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"inflammations"
],
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]
],
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]
},
{
"id": "DerHautarzt.60470169.eng.abstr-s2-t5",
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"tumor"
],
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"db_id": "C0027651"
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]
},
{
"id": "DerHautarzt.60470169.eng.abstr-s2-t6",
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"metastasis"
],
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262,
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},
{
"id": "DerHautarzt.60470169.eng.abstr-s2-t7",
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"pathologic processes"
],
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],
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},
{
"id": "DerHautarzt.60470169.eng.abstr-s2-t8",
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"homing behavior"
],
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},
{
"id": "DerHautarzt.60470169.eng.abstr-s2-t9",
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"text": [
"tumor metastasis"
],
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},
{
"id": "DerHautarzt.60470169.eng.abstr-s3-t1",
"type": "umlsterm",
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"adhesions"
],
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[
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},
{
"id": "DerHautarzt.60470169.eng.abstr-s3-t2",
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"tumor"
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{
"id": "DerHautarzt.60470169.eng.abstr-s3-t3",
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"cells"
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{
"id": "DerHautarzt.60470169.eng.abstr-s3-t4",
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}
] |
[] |
[] |
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] |
DerHautarzt.60470173.eng.abstr
|
DerHautarzt.60470173.eng.abstr
|
[
{
"id": "DerHautarzt.60470173.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The oral retinoid etretinate ( Tigason ) has recently been replaced by trans-acitretin ( Neotigason ) in the treatment of severe psoriasis , primarily because of its short half-life and the assumption that a shorter period of subsequent contraception would be required . After introduction of the new drug , however , circulating quantities of etretinate were detected in patients treated with trans-acitretin . Thus far , re-esterification has been detected in at least 83 cases . The 2-month period of strict contraception initially recommended after oral intake of trans-acitretin has been extended to 2 years , as with etretinate . We review some aspects of trans-acitretin metabolism , with special emphasis on etretinate formation . Re-esterification of trans-acitretin into etretinate takes place under varying conditions in volunteers and patients , as well as in animal models . Ethanol is a co-factor for the enzymatic re-esterification of trans-acitretin . It is unclear whether the introduction of trans-acitretin has been of any significant benefit to patients . Monitoring of plasma retinoid levels during and after retinoid therapy remains of decisive importance in managing difficult cases and or in approving decisions for pregnancy ."
],
"offsets": [
[
0,
1251
]
]
}
] |
[
{
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],
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[
9,
17
]
],
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{
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"db_id": "C0035339"
}
]
},
{
"id": "DerHautarzt.60470173.eng.abstr-s1-t2",
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"text": [
"etretinate"
],
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[
18,
28
]
],
"normalized": [
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}
]
},
{
"id": "DerHautarzt.60470173.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"Tigason"
],
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[
31,
38
]
],
"normalized": [
{
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DerHautarzt.60470178.eng.abstr
|
DerHautarzt.60470178.eng.abstr
|
[
{
"id": "DerHautarzt.60470178.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The use of porcine skin as a biomedical model for the human integument is discussed with reference to the literature . The epidermis and dermis can be used as a model as there are clear structural , functional and biochemical similarities with human skin layers . The actual utilization of porcine skin in dermatological research is reviewed . Practical difficulties are emphasized : in particular , the conditions required for use of porcine skin in experimental research , the most suitable breeds , and restrictions on biological interpretation of the results ."
],
"offsets": [
[
0,
564
]
]
}
] |
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"id": "DerHautarzt.60470178.eng.abstr-s1-t2",
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"id": "DerHautarzt.60470178.eng.abstr-s3-t1",
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DerHautarzt.60470183.eng.abstr
|
DerHautarzt.60470183.eng.abstr
|
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"We treated 166 infants and children with 177 hemangiomas with the flashlamp-pumped pulsed dye laser ( FPDL , 585 nm , 450 µs, 5 mm ) . The hemangiomas were classified as initial , superficial , cutaneous-nodular , and compound ( cutaneous-subcutaneous ) lesions according to the clinical involvement . After one treatment ( n=124), good results ( > 75% clearance ) were obtained in 56% of the initial and in 36% of the nodular lesions . With repeated treatment sessions ( n=82), good results were achieved in 63% of the initial , in 67% of the superficial and in 70% of the nodular angiomas . Complete resolution requiring one or more treatment sessions was reached in 44% of the initial , in 42% of the superficial and in 16% of the nodular lesions . In compound lesions , only the cutaneous part responds to treatment owing to the limited penetration depth of the laser light . In our opinion , early FPDL therapy of most initial and/or rapidly growing hemangiomas should be recommended , especially since this therapy is fast , has few side effects and can even be used in newborns ."
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[] |
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] |
DerHautarzt.60470190.eng.abstr
|
DerHautarzt.60470190.eng.abstr
|
[
{
"id": "DerHautarzt.60470190.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The therapeutic effect and the side effects of fumaric acid derivatives used in treatment of psoriasis vulgaris have been subjects of controversy for more than 30 years . A total of 83 patients with severe psoriasis vulgaris were investigated in as ingle-centre , long-term open ( 12 months ) clinical trial to evaluate the efficacy and safety profile of the fumaric acid ester preparations Fumaderm initial and Fumaderm . The antipsoriatic effect of the fumaric acid derivatives was clear , with a mean reduction of 76% in PASI . Adverse events in were noted in 62% of the patients ( mainly flushing and gastrointestinal complaints ) . These were dose-dependent and decreased in frequency in the course of the study . No severe adverse events occurred . We believe that of fumaric acid derivatives are indicated in cases of severe therapy-resistant psoriasis to and can be used even for long-term application ."
],
"offsets": [
[
0,
911
]
]
}
] |
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"acid"
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"id": "DerHautarzt.60470190.eng.abstr-s1-t4",
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"treatment"
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"id": "DerHautarzt.60470190.eng.abstr-s1-t5",
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"psoriasis"
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"id": "DerHautarzt.60470190.eng.abstr-s1-t6",
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"side effects"
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31,
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{
"id": "DerHautarzt.60470190.eng.abstr-s2-t2",
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"psoriasis"
],
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206,
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{
"id": "DerHautarzt.60470190.eng.abstr-s2-t3",
"type": "umlsterm",
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"open"
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"id": "DerHautarzt.60470190.eng.abstr-s2-t4",
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"safety"
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"ester"
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"id": "DerHautarzt.60470190.eng.abstr-s2-t7",
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"Fumaderm"
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"id": "DerHautarzt.60470190.eng.abstr-s2-t8",
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"id": "DerHautarzt.60470190.eng.abstr-s5-t1",
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"frequency"
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}
] |
[] |
[] |
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] |
DerHautarzt.60470197.eng.abstr
|
DerHautarzt.60470197.eng.abstr
|
[
{
"id": "DerHautarzt.60470197.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Tyrosinase mRNA produced by melanoma cells can be detected by reverse transcriptase-polymerase chain reaction ( rt-pcr ) with fine-needle tissue punctures . Fine-needle punctures from six suspected skin and lymph node metastases in three patients with malignant melanoma were analysed via rt-pcr for tyrosinase mRNA . All the suspected metastases were surgically removed and histologically examined separately . In each case the rt-pcr results and the histological diagnosis corresponded . This less invasive and highly sensitive method could prove to be a useful alternative in the diagnosis of melanoma metastasis ."
],
"offsets": [
[
0,
617
]
]
}
] |
[
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"Tyrosinase"
],
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[
0,
10
]
],
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"db_name": "UMLS",
"db_id": "C0041484"
}
]
},
{
"id": "DerHautarzt.60470197.eng.abstr-s1-t2",
"type": "umlsterm",
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"mRNA"
],
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11,
15
]
],
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}
]
},
{
"id": "DerHautarzt.60470197.eng.abstr-s1-t3",
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"text": [
"melanoma"
],
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[
28,
36
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],
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"db_id": "C0025202"
}
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},
{
"id": "DerHautarzt.60470197.eng.abstr-s1-t4",
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"text": [
"cells"
],
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37,
42
]
],
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},
{
"id": "DerHautarzt.60470197.eng.abstr-s1-t6",
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"text": [
"fine-needle"
],
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126,
137
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{
"id": "DerHautarzt.60470197.eng.abstr-s1-t7",
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},
{
"id": "DerHautarzt.60470197.eng.abstr-s1-t8",
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"punctures"
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154
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],
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},
{
"id": "DerHautarzt.60470197.eng.abstr-s2-t1",
"type": "umlsterm",
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"Fine-needle"
],
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157,
168
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],
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}
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},
{
"id": "DerHautarzt.60470197.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"skin"
],
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[
198,
202
]
],
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"db_id": "C0037267"
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},
{
"id": "DerHautarzt.60470197.eng.abstr-s2-t3",
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"text": [
"lymph"
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207,
212
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],
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},
{
"id": "DerHautarzt.60470197.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"metastases"
],
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218,
228
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],
"normalized": [
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}
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},
{
"id": "DerHautarzt.60470197.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"patients"
],
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[
238,
246
]
],
"normalized": [
{
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"db_id": "C0030705"
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},
{
"id": "DerHautarzt.60470197.eng.abstr-s2-t6",
"type": "umlsterm",
"text": [
"malignant"
],
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252,
261
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],
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}
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},
{
"id": "DerHautarzt.60470197.eng.abstr-s2-t7",
"type": "umlsterm",
"text": [
"melanoma"
],
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262,
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},
{
"id": "DerHautarzt.60470197.eng.abstr-s2-t8",
"type": "umlsterm",
"text": [
"tyrosinase"
],
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300,
310
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],
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},
{
"id": "DerHautarzt.60470197.eng.abstr-s2-t9",
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] |
DerHautarzt.60470200.eng.abstr
|
DerHautarzt.60470200.eng.abstr
|
[
{
"id": "DerHautarzt.60470200.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A total of 205 patients suffering from stage I and stage II melanoma were investigated with reference to psychosocial stress , social support and attitude to offers of psychotherapeutic support . Additional counselling by their dermatologist was considered helpful by 59% of the patients , and interviews with a psychotherapist , by 20% . Patients who where more anxious about a progression of the cancer and thought they had not been given sufficient information about their illness preferred to seek help from the dermatologist . Patients who appreciated additional counselling by a psychotherapist were usually those with a poorer prognosis for their melanoma and those on whom psychosocial distress weighed especially heavily and who had less social support ."
],
"offsets": [
[
0,
763
]
]
}
] |
[
{
"id": "DerHautarzt.60470200.eng.abstr-s1-t1",
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"patients"
],
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[
15,
23
]
],
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{
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}
]
},
{
"id": "DerHautarzt.60470200.eng.abstr-s1-t2",
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"stage"
],
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[
39,
44
]
],
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{
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"db_id": "C0027646"
}
]
},
{
"id": "DerHautarzt.60470200.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"melanoma"
],
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[
60,
68
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0025202"
}
]
},
{
"id": "DerHautarzt.60470200.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"stress"
],
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[
118,
124
]
],
"normalized": [
{
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"db_id": "C0038435"
}
]
},
{
"id": "DerHautarzt.60470200.eng.abstr-s1-t5",
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"text": [
"attitude"
],
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[
146,
154
]
],
"normalized": [
{
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"db_id": "C0004271"
}
]
},
{
"id": "DerHautarzt.60470200.eng.abstr-s1-t6",
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"social support"
],
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[
127,
141
]
],
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{
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"db_id": "C0037438"
}
]
},
{
"id": "DerHautarzt.60470200.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"patients"
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[
279,
287
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{
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}
]
},
{
"id": "DerHautarzt.60470200.eng.abstr-s2-t2",
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"text": [
"interviews"
],
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294,
304
]
],
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{
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},
{
"id": "DerHautarzt.60470200.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"Patients"
],
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[
339,
347
]
],
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{
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"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.60470200.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"cancer"
],
"offsets": [
[
398,
404
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0006826"
}
]
},
{
"id": "DerHautarzt.60470200.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"Patients"
],
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[
532,
540
]
],
"normalized": [
{
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}
]
},
{
"id": "DerHautarzt.60470200.eng.abstr-s4-t2",
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],
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],
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"db_id": "C0033325"
}
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},
{
"id": "DerHautarzt.60470200.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"melanoma"
],
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654,
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],
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]
},
{
"id": "DerHautarzt.60470200.eng.abstr-s4-t4",
"type": "umlsterm",
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"social support"
],
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[
747,
761
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0037438"
}
]
}
] |
[] |
[] |
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DerHautarzt.60470209.eng.abstr
|
DerHautarzt.60470209.eng.abstr
|
[
{
"id": "DerHautarzt.60470209.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Confluent and reticulated papillomatosis ( CRP ) is a rare dermatosis of unknown aetiology . Recent electron microscopic studies suggest that CRP is a disorder of keratinisation . In our case we could not confirm the previously reported ultrastructural findings . CRP is generally resistant to therapy . We treated a 19-year-old patient with typical CRP with oral minocycline . Within a few weeks the eruption resolved completely . A mild relapse 7 months later responded promptly to a repeated course of minocycline . Twelve months after discontinuatin of therapy there is no evidence of recurrence . In CRP minocycline should be preferred to systemic retinoid therapy because of its minor side effects ."
],
"offsets": [
[
0,
705
]
]
}
] |
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{
"id": "DerHautarzt.60470209.eng.abstr-s1-t1",
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{
"id": "DerHautarzt.60470209.eng.abstr-s1-t3",
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"disorder"
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"CRP"
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},
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"id": "DerHautarzt.60470209.eng.abstr-s5-t2",
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"id": "DerHautarzt.60470209.eng.abstr-s9-t3",
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"id": "DerHautarzt.60470209.eng.abstr-s9-t5",
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}
] |
[] |
[] |
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DerHautarzt.60470218.eng.abstr
|
DerHautarzt.60470218.eng.abstr
|
[
{
"id": "DerHautarzt.60470218.eng.abstr-passage-0",
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"text": [
"In this paper we present two patients with T-cell lymphomas , who presented with unique skin lesions , but later developed extracutaneous involvement . The first patient showed marked edematous infiltration of the trunk and legs as well as grouped , umbilicated red-to-blue papules limited to the body folds . The second patient had lesions reminiscent of poikiloderma vasculare atrophicans , with erythema , teleangiectasia , hypo- and hyperpigmentation , and bizarre scarring , followed by development of papules and nodules . The first patient also had marked leukocytosis and lymph node enlargement . Histology , immunohistology , and immunophenotyping revealed an unclassifiable CD8+, , + , CD10+ cutaneous T-cell lymphoma with leukemic involvement . Unclassifiable cutaneous T-cell lymphoma was also diagnosted in the second patient : it was associated with a monoclonal proliferation of T-cell receptor V9,+ large granular T lymphocytes and finally developed into frank , acute pre-T lymphatic leukemia ."
],
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[
0,
1011
]
]
}
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] |
[] |
[] |
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DerHautarzt.60470253.eng.abstr
|
DerHautarzt.60470253.eng.abstr
|
[
{
"id": "DerHautarzt.60470253.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Dermatological rehabilitation treatment can take different forms : climato-therapy , baths , phototherapy and psychosomatic treatments . Which of these treatments is of most benefit to any one patient depends on his or her illness . Accordingly , a psychosomatic approach to dermatological illness is indicated mainly when a psychological disorder and a dermatological disease coincide . In addtion , dermatoses with psychological triggers or overlays , and also depression , pre-existing emotional disorders and special motivation for psychotherapy should be considered for psychosomatic treatment . Finally , patients who are having trouble accepting or confronting malignant skin tumours may also benefit ."
],
"offsets": [
[
0,
709
]
]
}
] |
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[] |
[] |
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DerHautarzt.60470258.eng.abstr
|
DerHautarzt.60470258.eng.abstr
|
[
{
"id": "DerHautarzt.60470258.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Leg venectasia is a common problem . Although there are a variety of therapeutic modalities , none of them gives satisfactory results . The effects of sclerotherapy in the treatment of telangiectasia with a small diameter are poor . Electrocoagulation and argon laser treatment often result in scarring . We studied the effectiveness of the flashlamp pumped pulsed dye laser at a wavelength of 585 nm in the treatment of leg venectasia . After repeated treatments using this laser system , only 30% of the vessels that looked blue on clinical examination could be removed ; we obtained better lightening of smaller red , telangiectatic vessels with a diameter up to 0.4 mm . However , hyperpigmentation frequently developed after treatment . In post-treatment biopsies , occlusion of the vessels was found . Based on these results , we recommend a combined therapy for leg venectasia . Larger diameter vessels should be treated with sclerotherapy , while finer telangiectasia can be treated with the flashlamp pumped pulsed dye laser ."
],
"offsets": [
[
0,
1035
]
]
}
] |
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}
] |
[] |
[] |
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DerHautarzt.60470264.eng.abstr
|
DerHautarzt.60470264.eng.abstr
|
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],
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}
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[] |
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DerHautarzt.60470273.eng.abstr
|
DerHautarzt.60470273.eng.abstr
|
[
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"id": "DerHautarzt.60470273.eng.abstr-passage-0",
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"Reconstruction of the navel after tumour excision with subsequent navel resection is of great aesthetic importance for the patient . Methods of navel reconstruction are found in the literature but do not provide an elegant solution to the problem . Our method permits reconstruction of the navel during wound closure , by creation of two opposing trapezoidal skin flaps at the excision margin in the midline of the body ; the umbilical fossa is then restored by jointly anchoring these flaps to the linea alba . Reconstruction has been successfully carried out in this way after melanoma excision in 7 patients ."
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0,
612
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[] |
[] |
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DerHautarzt.60470276.eng.abstr
|
DerHautarzt.60470276.eng.abstr
|
[
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"For over 100 years many different methods have been used to determine capillary resistance as a measure of small vessel fragility . There is still no firm agreement as to the most suitable method ; the procedure is not standardized and an objective system for measurement is lacking . We have developed a computerized system that makes it possible to count petechiae and determine their area without the results varying with different examiners . Although we tried to keep the conditions for our examinations constant , we found a wide individual spread . In spite of this , the capillary resistance of atopic subjects was significantly lower than that of healthy persons ."
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673
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[] |
[] |
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] |
DerHautarzt.60470281.eng.abstr
|
DerHautarzt.60470281.eng.abstr
|
[
{
"id": "DerHautarzt.60470281.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A 39-year-old female patient presented with an intense allergic reaction and shock after ingesting sunflower seeds and simultaneously acetylsalicylic acid ( ASA ) . Skin tests and CAP specific . IgE demonstrated an IgE-mediated sensibilization to sunflower seeds . When sunflower seeds were eaten alone , only discrete paresthesias of the oral mucosa occurred . Surprisingly , an oral challenge with ASA was well tolerated . The supplementary centribution of ASA to the allergic reaction was done-dependent . The quantity of the allergen also modified the intensity of the symptoms . This surprising effect of ASA may be attributed to increased gastric resorption of the allergens . During the course of this reaction , eosinophil-cationic-protein was released ."
],
"offsets": [
[
0,
762
]
]
}
] |
[
{
"id": "DerHautarzt.60470281.eng.abstr-s1-t1",
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"female"
],
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14,
20
]
],
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"db_id": "C0086287"
},
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"db_id": "C0015780"
}
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},
{
"id": "DerHautarzt.60470281.eng.abstr-s1-t2",
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"text": [
"patient"
],
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[
21,
28
]
],
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"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.60470281.eng.abstr-s1-t3",
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"text": [
"sunflower"
],
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99,
108
]
],
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{
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"db_id": "C0087040"
}
]
},
{
"id": "DerHautarzt.60470281.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"seeds"
],
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[
109,
114
]
],
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"db_id": "C0036563"
}
]
},
{
"id": "DerHautarzt.60470281.eng.abstr-s1-t5",
"type": "umlsterm",
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"acid"
],
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[
150,
154
]
],
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{
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}
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},
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"id": "DerHautarzt.60470281.eng.abstr-s1-t6",
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"ASA"
],
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[
157,
160
]
],
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"db_id": "C0004057"
}
]
},
{
"id": "DerHautarzt.60470281.eng.abstr-s1-t7",
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"allergic reaction"
],
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[
55,
72
]
],
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"db_id": "C0085600"
}
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},
{
"id": "DerHautarzt.60470281.eng.abstr-s1-t8",
"type": "umlsterm",
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"acetylsalicylic acid"
],
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134,
154
]
],
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}
]
},
{
"id": "DerHautarzt.60470281.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"Skin"
],
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[
165,
169
]
],
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{
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"db_id": "C0037267"
}
]
},
{
"id": "DerHautarzt.60470281.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"tests"
],
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[
170,
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]
],
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}
]
},
{
"id": "DerHautarzt.60470281.eng.abstr-s2-t3",
"type": "umlsterm",
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"Skin tests"
],
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[
165,
175
]
],
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}
]
},
{
"id": "DerHautarzt.60470281.eng.abstr-s3-t1",
"type": "umlsterm",
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"IgE"
],
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195,
198
]
],
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}
]
},
{
"id": "DerHautarzt.60470281.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"sunflower"
],
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247,
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]
],
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{
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}
]
},
{
"id": "DerHautarzt.60470281.eng.abstr-s3-t3",
"type": "umlsterm",
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"seeds"
],
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257,
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],
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}
]
},
{
"id": "DerHautarzt.60470281.eng.abstr-s4-t1",
"type": "umlsterm",
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"sunflower"
],
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270,
279
]
],
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}
]
},
{
"id": "DerHautarzt.60470281.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"seeds"
],
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280,
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]
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]
},
{
"id": "DerHautarzt.60470281.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"mucosa"
],
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344,
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},
{
"id": "DerHautarzt.60470281.eng.abstr-s4-t4",
"type": "umlsterm",
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"oral mucosa"
],
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]
],
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"db_id": "C0026639"
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},
{
"id": "DerHautarzt.60470281.eng.abstr-s5-t1",
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"ASA"
],
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},
{
"id": "DerHautarzt.60470281.eng.abstr-s6-t1",
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"centribution"
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"id": "DerHautarzt.60470281.eng.abstr-s6-t2",
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"id": "DerHautarzt.60470281.eng.abstr-s6-t3",
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},
{
"id": "DerHautarzt.60470281.eng.abstr-s6-t4",
"type": "umlsterm",
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{
"id": "DerHautarzt.60470281.eng.abstr-s7-t1",
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"allergen"
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"id": "DerHautarzt.60470281.eng.abstr-s7-t2",
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{
"id": "DerHautarzt.60470281.eng.abstr-s8-t1",
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{
"id": "DerHautarzt.60470281.eng.abstr-s9-t1",
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"id": "DerHautarzt.60470281.eng.abstr-s9-t2",
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}
] |
[] |
[] |
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},
{
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DerHautarzt.60470284.eng.abstr
|
DerHautarzt.60470284.eng.abstr
|
[
{
"id": "DerHautarzt.60470284.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Microcystic adnexal carcinoma is a rare semimalignant cutaneous neoplasm characterised by slow but locally aggressive growth . Its histogenesis and nomenclature are still a subject of controversy . Under-recognition and the tumour's bland cytologic features lead to frequent misdiagnoses . In addition , subclinical tumour invasion explains the high incidence of local recurrence . Thus , the tumour makes great demands on the planning of its surgical removal . We report the case of an 81-year-old woman with a microcystic adnexal carcinoma of the lower lip , which was treated by micrographic surgery . On the basis of this case , differential diagnoses , histogenesis and micrographic surgery as the treatment of choice are discussed ."
],
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[
0,
738
]
]
}
] |
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"id": "DerHautarzt.60470284.eng.abstr-s1-t1",
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"id": "DerHautarzt.60470284.eng.abstr-s1-t2",
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"id": "DerHautarzt.60470284.eng.abstr-s1-t3",
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"id": "DerHautarzt.60470284.eng.abstr-s1-t4",
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"id": "DerHautarzt.60470284.eng.abstr-s1-t5",
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] |
[] |
[] |
[
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}
] |
DerHautarzt.60470299.eng.abstr
|
DerHautarzt.60470299.eng.abstr
|
[
{
"id": "DerHautarzt.60470299.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report on a 9-year-old girl with a giant cell fibroblastoma of the right anterior chest wall . This rare soft tissue tumour occurs predominantly in the first two decades of life . The typical clinical presentation is a solitary , usually 2-6 cm large , non-tender mass of blue-greyish colour which is mostly located on the back , anterior chest wall , thigh or groin . The histology shows a loose infiltrate of predominantly bland spindle cells in dermis and subcutis . Characteristic elements of the tumour are large angiectoid branching spaces lacking any endo- or epithelium , and relatively small multinucleated cells ( floret cells ) . The recurrence rate is high if the tumour is not excised with adequate safety margins . Metastases are not report . It is of pre-eminent importance to differentiate this rare benign tumor from sarcomas , in order to avoid an inappropriately aggressive therapy ."
],
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[
0,
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}
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] |
[] |
[] |
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DerHautarzt.60470304.eng.abstr
|
DerHautarzt.60470304.eng.abstr
|
[
{
"id": "DerHautarzt.60470304.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The syndrome of perifollicular fibromas and colonic polyps was delineated 20 years ago by Hornstein and Knickenberg ; it probably occurs more frequently than suggested by the literature . Multiple perifollicular fibromas were found in a mother and daughter . The mother also had colonic polyps . This dermo-intestinal syndrome varies in its clinical manifestations , but it is probably an autosomal dominant trait . We believe that the Hornstein-Knickenberg syndrome and the Birt-Hogg-Dubé syndrome are identical . If perifollicular fibromas are observed and cannot be explained as postinflammatory sequelae of acne , the patient should be examined for colonic polyps as an appropriate form of cancer screening ."
],
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[
0,
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]
]
}
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] |
[] |
[] |
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DerHautarzt.60470307.eng.abstr
|
DerHautarzt.60470307.eng.abstr
|
[
{
"id": "DerHautarzt.60470307.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Severe dystrophic epidermolysis bullosa with oral involvement often leads to dental destruction and restricted food intake , resulting in malnutrition and maldevelopment . The patients become handicapped and have a poor prognosis . We report on a now 13-year-old Turkish child with normal secondary dentition who had severely damaged primary dentition . The teeth were treated surgically and then by continuous dental hygiene measures over the next 7 years . This care also resulted in an improvement in the nutritional state , associated anemia and the incidence of skin infections . Although cutaneous blistering and scarring has been progressive , with resulting mutilation of the fingers , the child is socially well adjusted in school and family . Its clinical course demonstrates that the fate of patients with severe dystrophic epidermolysis bullosa can be improved through multidisciplinary management ."
],
"offsets": [
[
0,
911
]
]
}
] |
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] |
[] |
[] |
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},
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"id": "DerHautarzt.60470307.eng.abstr-s5-r21-t7.1-t4.1",
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},
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"id": "DerHautarzt.60470307.eng.abstr-s6-r1-t4.1-t3.1",
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},
{
"id": "DerHautarzt.60470307.eng.abstr-s6-r2-t2.1-t3.1",
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},
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},
{
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},
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"id": "DerHautarzt.60470307.eng.abstr-s7-r1-t2.1-t1.1",
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},
{
"id": "DerHautarzt.60470307.eng.abstr-s7-r2-t2.1-t3.1",
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"id": "DerHautarzt.60470307.eng.abstr-s7-r3-t3.1-t1.1",
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"id": "DerHautarzt.60470307.eng.abstr-s7-r4-t3.1-t2.1",
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"normalized": []
}
] |
DerHautarzt.60470336.eng.abstr
|
DerHautarzt.60470336.eng.abstr
|
[
{
"id": "DerHautarzt.60470336.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The Raynaud phenomenon occurs in 90-100% of patients with systemic scleroderma . It is caused by dysregulation of the vascular tone between vasocontrictive and vasodilatory influences . Early damage to the vascular endothelium and the activation of platelets lead to the release of vasoactive substances . Structural and function impairment of the perivascular neural fibers contributes to the vasospasm . New vasodilatory treatment strategies , e.g. infusions with calcitonin gene-related peptides , could be useful in the control of vasospasm in the peripheral extremities as well as internal organs in systemic scleroderma ."
],
"offsets": [
[
0,
627
]
]
}
] |
[
{
"id": "DerHautarzt.60470336.eng.abstr-s1-t1",
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"patients"
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]
],
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"db_id": "C0030705"
}
]
},
{
"id": "DerHautarzt.60470336.eng.abstr-s1-t2",
"type": "umlsterm",
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"scleroderma"
],
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67,
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]
],
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"db_id": "C0011644"
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}
]
},
{
"id": "DerHautarzt.60470336.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"systemic scleroderma"
],
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[
58,
78
]
],
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{
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"db_id": "C0036421"
}
]
},
{
"id": "DerHautarzt.60470336.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"endothelium"
],
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[
215,
226
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0014257"
}
]
},
{
"id": "DerHautarzt.60470336.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"platelets"
],
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[
249,
258
]
],
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{
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"db_id": "C0005821"
}
]
},
{
"id": "DerHautarzt.60470336.eng.abstr-s3-t3",
"type": "umlsterm",
"text": [
"release"
],
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[
271,
278
]
],
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{
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"db_id": "C0541720"
}
]
},
{
"id": "DerHautarzt.60470336.eng.abstr-s3-t4",
"type": "umlsterm",
"text": [
"vascular endothelium"
],
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[
206,
226
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0014261"
}
]
},
{
"id": "DerHautarzt.60470336.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"function"
],
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[
321,
329
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0031843"
}
]
},
{
"id": "DerHautarzt.60470336.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"treatment"
],
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[
423,
432
]
],
"normalized": [
{
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"db_id": "C0087111"
},
{
"db_name": "UMLS",
"db_id": "C0039798"
}
]
},
{
"id": "DerHautarzt.60470336.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"calcitonin"
],
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[
466,
476
]
],
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{
"db_name": "UMLS",
"db_id": "C0006668"
}
]
},
{
"id": "DerHautarzt.60470336.eng.abstr-s5-t3",
"type": "umlsterm",
"text": [
"peptides"
],
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490,
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]
],
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{
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}
]
},
{
"id": "DerHautarzt.60470336.eng.abstr-s5-t4",
"type": "umlsterm",
"text": [
"control"
],
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524,
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]
],
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{
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"db_id": "C0243148"
}
]
},
{
"id": "DerHautarzt.60470336.eng.abstr-s5-t5",
"type": "umlsterm",
"text": [
"extremities"
],
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[
563,
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]
],
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{
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"db_id": "C0015385"
}
]
},
{
"id": "DerHautarzt.60470336.eng.abstr-s5-t6",
"type": "umlsterm",
"text": [
"scleroderma"
],
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[
614,
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]
],
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{
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"db_id": "C0011644"
},
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}
]
},
{
"id": "DerHautarzt.60470336.eng.abstr-s5-t7",
"type": "umlsterm",
"text": [
"systemic scleroderma"
],
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[
605,
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]
],
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{
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"db_id": "C0036421"
}
]
},
{
"id": "DerHautarzt.60470336.eng.abstr-s5-t8",
"type": "umlsterm",
"text": [
"calcitonin gene-related peptides"
],
"offsets": [
[
466,
498
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0006669"
}
]
}
] |
[] |
[] |
[
{
"id": "DerHautarzt.60470336.eng.abstr-s3-r1-t2.1-t3.1",
"type": "produces",
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{
"id": "DerHautarzt.60470336.eng.abstr-s3-r2-t3.1-t2.1",
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},
{
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},
{
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},
{
"id": "DerHautarzt.60470336.eng.abstr-s3-r5-t2.1-t3.1",
"type": "surrounds",
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"arg2_id": "DerHautarzt.60470336.eng.abstr-s5-t3",
"normalized": []
},
{
"id": "DerHautarzt.60470336.eng.abstr-s3-r6-t2.1-t1.1",
"type": "surrounds",
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"arg2_id": "DerHautarzt.60470336.eng.abstr-s5-t1",
"normalized": []
},
{
"id": "DerHautarzt.60470336.eng.abstr-s3-r7-t1.1-t2.1",
"type": "surrounds",
"arg1_id": "DerHautarzt.60470336.eng.abstr-s5-t1",
"arg2_id": "DerHautarzt.60470336.eng.abstr-s5-t2",
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},
{
"id": "DerHautarzt.60470336.eng.abstr-s3-r8-t2.1-t3.1",
"type": "part_of",
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},
{
"id": "DerHautarzt.60470336.eng.abstr-s3-r9-t1.1-t3.1",
"type": "produces",
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"arg2_id": "DerHautarzt.60470336.eng.abstr-s5-t3",
"normalized": []
},
{
"id": "DerHautarzt.60470336.eng.abstr-s3-r10-t2.1-t1.1",
"type": "part_of",
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},
{
"id": "DerHautarzt.60470336.eng.abstr-s5-r1-t1.1-t8.1",
"type": "interacts_with",
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"arg2_id": "DerHautarzt.60470336.eng.abstr-s5-t8",
"normalized": []
},
{
"id": "DerHautarzt.60470336.eng.abstr-s5-r2-t4.1-t7.1",
"type": "location_of",
"arg1_id": "DerHautarzt.60470336.eng.abstr-s5-t4",
"arg2_id": "DerHautarzt.60470336.eng.abstr-s5-t7",
"normalized": []
},
{
"id": "DerHautarzt.60470336.eng.abstr-s5-r3-t3.1-t8.1",
"type": "interacts_with",
"arg1_id": "DerHautarzt.60470336.eng.abstr-s5-t3",
"arg2_id": "DerHautarzt.60470336.eng.abstr-s5-t8",
"normalized": []
},
{
"id": "DerHautarzt.60470336.eng.abstr-s5-r4-t8.1-t7.1",
"type": "affects",
"arg1_id": "DerHautarzt.60470336.eng.abstr-s5-t8",
"arg2_id": "DerHautarzt.60470336.eng.abstr-s5-t7",
"normalized": []
},
{
"id": "DerHautarzt.60470336.eng.abstr-s5-r5-t4.1-t1.1",
"type": "location_of",
"arg1_id": "DerHautarzt.60470336.eng.abstr-s5-t4",
"arg2_id": "DerHautarzt.60470336.eng.abstr-s5-t1",
"normalized": []
},
{
"id": "DerHautarzt.60470336.eng.abstr-s5-r6-t3.1-t7.1",
"type": "affects",
"arg1_id": "DerHautarzt.60470336.eng.abstr-s5-t3",
"arg2_id": "DerHautarzt.60470336.eng.abstr-s5-t7",
"normalized": []
},
{
"id": "DerHautarzt.60470336.eng.abstr-s5-r7-t1.1-t7.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.60470336.eng.abstr-s5-t1",
"arg2_id": "DerHautarzt.60470336.eng.abstr-s5-t7",
"normalized": []
},
{
"id": "DerHautarzt.60470336.eng.abstr-s5-r8-t8.1-t3.1",
"type": "interacts_with",
"arg1_id": "DerHautarzt.60470336.eng.abstr-s5-t8",
"arg2_id": "DerHautarzt.60470336.eng.abstr-s5-t3",
"normalized": []
},
{
"id": "DerHautarzt.60470336.eng.abstr-s5-r9-t4.1-t6.1",
"type": "location_of",
"arg1_id": "DerHautarzt.60470336.eng.abstr-s5-t4",
"arg2_id": "DerHautarzt.60470336.eng.abstr-s5-t6",
"normalized": []
},
{
"id": "DerHautarzt.60470336.eng.abstr-s5-r10-t1.1-t6.1",
"type": "associated_with",
"arg1_id": "DerHautarzt.60470336.eng.abstr-s5-t1",
"arg2_id": "DerHautarzt.60470336.eng.abstr-s5-t6",
"normalized": []
},
{
"id": "DerHautarzt.60470336.eng.abstr-s5-r11-t1.1-t6.1",
"type": "affects",
"arg1_id": "DerHautarzt.60470336.eng.abstr-s5-t1",
"arg2_id": "DerHautarzt.60470336.eng.abstr-s5-t6",
"normalized": []
},
{
"id": "DerHautarzt.60470336.eng.abstr-s5-r12-t3.1-t1.1",
"type": "interacts_with",
"arg1_id": "DerHautarzt.60470336.eng.abstr-s5-t3",
"arg2_id": "DerHautarzt.60470336.eng.abstr-s5-t1",
"normalized": []
},
{
"id": "DerHautarzt.60470336.eng.abstr-s5-r13-t8.1-t1.1",
"type": "interacts_with",
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"arg2_id": "DerHautarzt.60470336.eng.abstr-s5-t1",
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},
{
"id": "DerHautarzt.60470336.eng.abstr-s5-r14-t8.1-t6.1",
"type": "affects",
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"arg2_id": "DerHautarzt.60470336.eng.abstr-s5-t6",
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},
{
"id": "DerHautarzt.60470336.eng.abstr-s5-r15-t3.1-t6.1",
"type": "affects",
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"arg2_id": "DerHautarzt.60470336.eng.abstr-s5-t6",
"normalized": []
},
{
"id": "DerHautarzt.60470336.eng.abstr-s5-r16-t1.1-t7.1",
"type": "affects",
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"arg2_id": "DerHautarzt.60470336.eng.abstr-s5-t7",
"normalized": []
},
{
"id": "DerHautarzt.60470336.eng.abstr-s5-r17-t1.1-t3.1",
"type": "interacts_with",
"arg1_id": "DerHautarzt.60470336.eng.abstr-s5-t1",
"arg2_id": "DerHautarzt.60470336.eng.abstr-s5-t3",
"normalized": []
}
] |
DerHautarzt.60470341.eng.abstr
|
DerHautarzt.60470341.eng.abstr
|
[
{
"id": "DerHautarzt.60470341.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Primary infection with human herpesviruses 6 and 7 ( HHV-6 and HHV-7) during early childhood causes permanent latent infection , usually without any ill effects ; only a small percentage of primary infections will lead to exanthem subitum . Like other herpesviruses , HHV-6 and HHV-7 can be reactivated at any time if host defence mechanisms become defective ( e.g. in transplant recipients , AIDS , tumour patients ) . HHV-6 can be reactivated under such conditions and cause a variety of clinical problems , such as exanthems along with interstitial pneumonia or hepatitis for example . In addition , the reactivated virus may influence the course of autoimmune and proliferative diseases such as systemic lupus erythematosus and Hodgkin's disease . While , HHV-7 may be associated with similar disorders , more systematic studies are needed to clarify the clinical implications and the pathogenetic mechanisms of both viruses ."
],
"offsets": [
[
0,
930
]
]
}
] |
[
{
"id": "DerHautarzt.60470341.eng.abstr-s1-t1",
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"text": [
"infection"
],
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[
8,
17
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0021311"
}
]
},
{
"id": "DerHautarzt.60470341.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"human"
],
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[
23,
28
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0020114"
}
]
},
{
"id": "DerHautarzt.60470341.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"herpesviruses"
],
"offsets": [
[
29,
42
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0019369"
}
]
},
{
"id": "DerHautarzt.60470341.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"HHV-6"
],
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[
53,
58
]
],
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{
"db_name": "UMLS",
"db_id": "C0019381"
}
]
},
{
"id": "DerHautarzt.60470341.eng.abstr-s1-t5",
"type": "umlsterm",
"text": [
"infection"
],
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[
117,
126
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0021311"
}
]
},
{
"id": "DerHautarzt.60470341.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"infections"
],
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[
198,
208
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0021311"
}
]
},
{
"id": "DerHautarzt.60470341.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"exanthem"
],
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[
222,
230
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0015230"
}
]
},
{
"id": "DerHautarzt.60470341.eng.abstr-s1-t8",
"type": "umlsterm",
"text": [
"exanthem subitum"
],
"offsets": [
[
222,
238
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0015231"
}
]
},
{
"id": "DerHautarzt.60470341.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"herpesviruses"
],
"offsets": [
[
252,
265
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0019369"
}
]
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}
] |
DerHautarzt.60470351.eng.abstr
|
DerHautarzt.60470351.eng.abstr
|
[
{
"id": "DerHautarzt.60470351.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The situation of women in dermatology was evaluated with the aid of questionnaires in spring 1994. A questionnaire was sent to 33 clinics in Germany and 46 in other European countries , asking about the proportions of male and female physicians in each department . In addition , individual department members were asked in another questionnaire about their reasons for choosing dermatology and about possible sex discrimination . The clinic questionnaires were returned from 22 German and 37 other European clinics and the individual questionnaires by 548 German physicians and 1164 physicians from the other countries ( overall 52% women ) . We found that 41.8% of the dermatologists in German clinics were women , as against 43.4% in the other countries . Women made up about half of the fully qualified specialists , but accounted for only a small percentage of those in higher positions ( 10.8% in Germany , 27.9% in other countries ) . Of the 1712 physicians who answered the individual questionnaire , the majority had chosen dermatology because of their interest in the specialty . Slightly more women than men gave other reasons , such as more free time - mostly for family matters - or less physical strain . Clearly more women than men felt they were discriminated against professionally because of their sex . The reasons for this related primarily to the biological and social role of women in society . Overall , women are thus well represented in our specialty , except in leading positions ."
],
"offsets": [
[
0,
1507
]
]
}
] |
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"id": "DerHautarzt.60470351.eng.abstr-s1-t2",
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}
] |
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