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DerPathologe.50160217.eng.abstr
DerPathologe.50160217.eng.abstr
[ { "id": "DerPathologe.50160217.eng.abstr-passage-0", "type": "abstract", "text": [ "Resection specimens of 14 patients with small cell bronchial carcinoma after neoadjuvant chemotherapy were processed histologically and graded according to a three-step regression grading system : grade I , no or only slight tumor regression ; grade II , incomplete tumor regression ; grade III , complete tumor regression without vital tumor tissue . In five patients with either no vital tumor tissue or only small tumor remnants in the resection samples , a typical sequence of central fresh tumor necrosis , foam cell rim , vascular granulation tissue and peripheral scar formation was seen . This morphological finding may be interpreted as a characteristic , but unspecific parameter of good response to preoperative chemotherapy . The presence of vital tumor rims surrounding the capillary bed with intermingled necrotic foci , however , argues in favor of spontaneous tumor regression , which is commonly observed in small cell lung cancer ." ], "offsets": [ [ 0, 949 ] ] } ]
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DerPathologe.50160245.eng.abstr
DerPathologe.50160245.eng.abstr
[ { "id": "DerPathologe.50160245.eng.abstr-passage-0", "type": "abstract", "text": [ "In recent years there has been considerable progress in brain tumor neuropathology . Several new diagnostic entities have been recognized , subclassification schemes have been modified , and new concepts on the histogenesis and cell biology of brain tumors have emerged . In 1993 , a revised WHO classification of brain tumors was published by an international committee . This article summarizes the pertinent new aspects . As novel tumor entities , the central neurocytoma , the dysembryoplastic neuroepithelial tumor ( DNT ) , desmoplastic infantile ganglioglioma ( DIG ) and pleomorphic xanthoastrocytoma ( PXA ) have been included . Several histopathological variants of meningiomas have been added of which only the papillary meningioma and the atypical meningioma are characterized by an increased rate of recurrence . Meningeal hemangiopericytomas and hemangioblastomas are classified as tumors of non-meningothelial origin . The glioblastoma multiforme , which had previously been listed as an embryonal tumor , is now recognized as an astrocytic glioma . Immunohistochemistry has greatly advanced the practical diagnosis and classification of brain tumors . There are specific markers for all normal and neoplastic cell types except for oligodendroglioma cells . The prognosis of and therapeutic approaches to brain tumors greatly depend on histopathological grading . The WHO proposes four tumor grades , i . e . , I , II , III , and IV . As a rule , grades I and II tumors are viewed as benign or semi-benign neoplasms and grades III and IV tumors as malignant . There are attempts to use new biological parameters for the grading of brain tumors . Antibodies to proliferation-associated proteins reflect tumor growth . Molecular genetic approaches to tumor-associated genes and gene loci are particularly promising new tools for the future ." ], "offsets": [ [ 0, 1854 ] ] } ]
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} ] }, { "id": "DerPathologe.50160245.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "biology" ], "offsets": [ [ 233, 240 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005532" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "brain" ], "offsets": [ [ 244, 249 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0153633" }, { "db_name": "UMLS", "db_id": "C0006104" }, { "db_name": "UMLS", "db_id": "C0496899" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "tumors" ], "offsets": [ [ 250, 256 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "brain tumors" ], "offsets": [ [ 244, 256 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006118" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "classification" ], "offsets": [ [ 296, 310 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008902" }, { "db_name": "UMLS", "db_id": "C0008903" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "brain" ], "offsets": [ [ 314, 319 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0153633" }, { "db_name": "UMLS", "db_id": "C0006104" }, { "db_name": "UMLS", "db_id": "C0496899" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "tumors" ], "offsets": [ [ 320, 326 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "brain tumors" ], "offsets": [ [ 314, 326 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006118" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "tumor" ], "offsets": [ [ 434, 439 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "neurocytoma" 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"db_name": "UMLS", "db_id": "C0243140" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "meningiomas" ], "offsets": [ [ 676, 687 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025286" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "meningioma" ], "offsets": [ [ 732, 742 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025286" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "meningioma" ], "offsets": [ [ 760, 770 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025286" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s6-t5", "type": "umlsterm", "text": [ "recurrence" ], "offsets": [ [ 813, 823 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034897" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s6-t6", "type": "umlsterm", "text": [ "papillary meningioma" ], "offsets": [ [ 722, 742 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0259786" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "hemangiopericytomas" ], "offsets": [ [ 836, 855 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018922" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s7-t2", "type": "umlsterm", "text": [ "hemangioblastomas" ], "offsets": [ [ 860, 877 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0206734" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s7-t3", "type": "umlsterm", "text": [ "tumors" ], "offsets": [ [ 896, 902 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s7-t4", "type": "umlsterm", "text": [ "origin" ], "offsets": [ [ 925, 931 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0079946" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s8-t1", "type": "umlsterm", "text": [ "glioblastoma" ], "offsets": [ [ 938, 950 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017636" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s8-t2", 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"umlsterm", "text": [ "tumors" ], "offsets": [ [ 1159, 1165 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s9-t6", "type": "umlsterm", "text": [ "brain tumors" ], "offsets": [ [ 1153, 1165 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006118" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s10-t1", "type": "umlsterm", "text": [ "markers" ], "offsets": [ [ 1187, 1194 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005516" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s10-t2", "type": "umlsterm", "text": [ "cell" ], "offsets": [ [ 1225, 1229 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s10-t3", "type": "umlsterm", "text": [ "oligodendroglioma" ], "offsets": [ [ 1247, 1264 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028945" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s10-t4", "type": "umlsterm", "text": [ "cells" ], "offsets": [ [ 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[ "histopathological" ], "offsets": [ [ 1351, 1368 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243140" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s11-t6", "type": "umlsterm", "text": [ "brain tumors" ], "offsets": [ [ 1320, 1332 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006118" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s12-t1", "type": "umlsterm", "text": [ "tumor" ], "offsets": [ [ 1401, 1406 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s15-t1", "type": "umlsterm", "text": [ "tumors" ], "offsets": [ [ 1478, 1484 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s15-t2", "type": "umlsterm", "text": [ "neoplasms" ], "offsets": [ [ 1521, 1530 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" }, { "db_name": "UMLS", "db_id": "C0036210" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s15-t3", "type": "umlsterm", "text": [ "tumors" ], "offsets": [ [ 1553, 1559 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s15-t4", "type": "umlsterm", "text": [ "malignant" ], "offsets": [ [ 1563, 1572 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006826" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s16-t1", "type": "umlsterm", "text": [ "brain" ], "offsets": [ [ 1646, 1651 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0153633" }, { "db_name": "UMLS", "db_id": "C0006104" }, { "db_name": "UMLS", "db_id": "C0496899" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s16-t2", "type": "umlsterm", "text": [ "tumors" ], "offsets": [ [ 1652, 1658 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s16-t3", "type": "umlsterm", "text": [ "brain tumors" ], "offsets": [ [ 1646, 1658 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006118" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s17-t1", "type": "umlsterm", "text": [ "Antibodies" ], "offsets": [ [ 1661, 1671 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003241" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s17-t2", "type": "umlsterm", "text": [ "proteins" ], "offsets": [ [ 1700, 1708 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033684" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s17-t3", "type": "umlsterm", "text": [ "tumor" ], "offsets": [ [ 1717, 1722 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s17-t4", "type": "umlsterm", "text": [ "growth" ], "offsets": [ [ 1723, 1729 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018270" }, { "db_name": "UMLS", "db_id": "C0220844" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s18-t1", "type": "umlsterm", "text": [ "genes" ], "offsets": [ [ 1781, 1786 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017337" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s18-t2", "type": "umlsterm", "text": [ "gene" ], "offsets": [ [ 1791, 1795 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017337" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s18-t3", "type": "umlsterm", "text": [ "future" ], "offsets": [ [ 1846, 1852 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016884" } ] }, { "id": "DerPathologe.50160245.eng.abstr-s18-t4", "type": "umlsterm", "text": [ "Molecular genetic" ], "offsets": [ [ 1732, 1749 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086345" } ] } ]
[]
[]
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DerPathologe.50160256.eng.abstr
DerPathologe.50160256.eng.abstr
[ { "id": "DerPathologe.50160256.eng.abstr-passage-0", "type": "abstract", "text": [ "For evaluation of the hormone receptor status in breast cancer tissues two methods are mainly used : immunohistochemical detection by monoclonal antibodies on frozen sections ( ER-ICA , PgR-ICA ) and the biochemical radioligand-binding assay ( DCC ) of fresh tissue . Using new antibodies makes it possible to evaluate the estrogen and progesterone receptor status in formalin-fixed and paraffin-embedded tissue . In the present retrospective study , tissues from 223 primary breast carcinomas or breast carcinoma recurrences were reevaluated with the three methods mentioned above and the results were compared . We used antibody 1D5.26 reacting with the estrogen receptor and mPR1 specific for the progesterone receptor in paraffin-embedded tissue . The agreement of positive and negative cases between these two immunohistochemical procedures was 97.8 % for the estrogen receptor and 85.7 % for the progesterone receptor . Comparison of immunohistochemistry on paraffin-embedded tissue and biochemical evaluation showed an agreement of 74.7 % for the estrogen receptor and 68.7 % for the progesterone receptor . These results are comparable to the correspondence between ER-ICA and PgR-ICA and the DCC method . This study proves that the prognostically and therapeutically important hormone receptors can be reliably determined in formalin-fixed and paraffin-embedded tissues . These results are not only important for the evaluation of hormone receptors of a small breast carcinoma that is not found in the frozen section , but for the considerable difference in costs among the different methods ." ], "offsets": [ [ 0, 1602 ] ] } ]
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DerPathologe.50160262.eng.abstr
DerPathologe.50160262.eng.abstr
[ { "id": "DerPathologe.50160262.eng.abstr-passage-0", "type": "abstract", "text": [ "Liver tissue from 14 female patients with primary biliary cirrhosis ( PBC ; stages I-IV ) was systematically investigated for the prevalence and distribution of dendritic antigen-presenting cells . Dendritic cells ( DCs ) were immunhistochemically identified by use of anti-S 100 protein and KiMlp antibodies . We confirm previous findings that , in early PBC , S 100 protein-positive DCs can be detected within the lining of bile duct epithelia . However , the present study disclosed that S 100 protein- and KiMlp-positive DCs regularly occur in piecemeal necroses ( PMNs ) developing in PBC-associated chronic hepatitis . DCs in PMNs were observed in all PBC stages , but were most prominent in late-stage PBC . These findings suggest that autoimmune tissue damage in PBC may not be limited to bile ducts , but may also ensue in hepatic parenchyma , producing the pattern of chronic hepatitis with signs of activity ." ], "offsets": [ [ 0, 920 ] ] } ]
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[]
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DerPathologe.50160269.eng.abstr
DerPathologe.50160269.eng.abstr
[ { "id": "DerPathologe.50160269.eng.abstr-passage-0", "type": "abstract", "text": [ "Primary and secondary meniscal chondrocalcinoses lead to typical changes in X-ray pictures of isolated menisci . Combined X-ray , light and electron microscopic examination of the four menisci in 70 autopsy cases showed calcifications in 13 cases ( 18.6 % ) . Three types of calcification could be discriminated with the help of topographical and morphological criteria : Type 1 A : disseminated calcification . All four menisci were affected equally . Crystals of calcium pyrophosphate dihydrate ( CPPD ) were found on light and electron microscopy . Energy-dispersive X-ray analysis ( EDX ) showed the crystal deposits to consist of 46.5 % calcium and 53.5 % phosphorus . Type 1 B : Calcification occurring in limited areas . A calcification was found which did affected neither a whole meniscus nor all four menisci of any \" quartet \" observed . Crystals were found next to areas of stronger meniscal degeneration . EDX showed the same results described for type 1 A. Type 2 : Confluent calcification . A cloud-like diffuse calcification was discerned on the X-ray pictures . Light and electron microscopically pseudocystic structures appeared which contained a fine granular amorphous material . No crystals were found . The structures appeared in the neighbourhood of necrotic fibres . EDX showed 44 % calcium , 51.2 % phosphorus , 2.8 % sulphur , 0.74 % magnesium and 0.6 % potassium . The findings lead to the conclusion that calcification type 1 A represents primary chondrocalcinosis , whereas type 1 B corresponds to secondary chondrocalcinosis . Type 2 was identified as postnecrotic , dystrophic calcification . Careful analysis of X-ray pictures of isolated menisci can yield useful information concerning pathogenetic factors of meniscal calcification ." ], "offsets": [ [ 0, 1767 ] ] } ]
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DerPathologe.50160278.eng.abstr
DerPathologe.50160278.eng.abstr
[ { "id": "DerPathologe.50160278.eng.abstr-passage-0", "type": "abstract", "text": [ "The synthesis of pS 2 protein is induced through estrogen-dependent transcription of the pS 2 gene . The presence of the pS 2 protein in breast cancer is thought to be as valuable as receptor status , or even more so , in predicting the response to hormonal therapy . Furthermore , pS 2 appears to be a prognostic factor for primary breast cancer . In 162 cases of primary breast cancer , pS 2 was tested by immunohistochemical procedures on formalin-fixed and paraffin-embedded tissues . Staining was evaluated semiquantitatively using an immunoreactive score ( IRS ) . The concentrations of pS 2 in tumor cytosol were determined using an immunoradiometric assay . Positive staining for pS 2 ( IRS > = 2 ) was seen in 27 % of the tumors . Comparison of immunohistochemical and biochemical detection ( 26 % of tumors had pS 2 cytosol concentrations above the cut-off value of 26 ng/mg cell protein ) revealed an 81 % concordance rate ( r = 0.76 ; P 0.0001 ) . Univariate analysis showed no significant correlation of immunohistochemical pS 2 detection and age or menopausal status of patients , tumor size , tumor grade or nodal status . However , the immunohistochemical pS 2 status correlated significantly with the immunohistochemical detection of the estrogen ( ER ; P 0.001 ) and progesterone receptor status ( PR ; P 0.0001 ) . pS 2-positive tumors were ER-positive in 66 % of cases and PR-positive in 73 % ; 89 % of pS 2-positive tumors were positive for ER and/or PR . The incidence of immunohistochemical pS 2 detection was 41 % in the group of steroid receptor positive carcinomas ( ER- and/or PR-positive ) in contrast to 7 % in steroid receptor negative tumors ( ER- and PR-negative ) ." ], "offsets": [ [ 0, 1698 ] ] } ]
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DerPathologe.50160285.eng.abstr
DerPathologe.50160285.eng.abstr
[ { "id": "DerPathologe.50160285.eng.abstr-passage-0", "type": "abstract", "text": [ "Dipterous fly maggots of different species live worldwide as parasites in hoofed mammals . In the host the larval development causes typical boils , i . e . , abscesses including the larvae . As a result of increasing tourist traffic , travelers can also bring back to Germany tropical types of myiasis ." ], "offsets": [ [ 0, 304 ] ] } ]
[ { "id": "DerPathologe.50160285.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "maggots" ], "offsets": [ [ 14, 21 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016386" } ] }, { "id": "DerPathologe.50160285.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "parasites" ], "offsets": [ [ 61, 70 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030498" }, { "db_name": "UMLS", "db_id": "C0521066" } ] }, { "id": "DerPathologe.50160285.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "mammals" ], "offsets": [ [ 81, 88 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024660" } ] }, { "id": "DerPathologe.50160285.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "development" ], "offsets": [ [ 114, 125 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243107" }, { "db_name": "UMLS", "db_id": "C0020119" } ] }, { "id": "DerPathologe.50160285.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "larvae" ], "offsets": [ [ 183, 189 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023047" } ] }, { "id": "DerPathologe.50160285.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "Germany" ], "offsets": [ [ 269, 276 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017480" } ] }, { "id": "DerPathologe.50160285.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "myiasis" ], "offsets": [ [ 295, 302 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027030" } ] } ]
[]
[]
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DerPathologe.50160287.eng.abstr
DerPathologe.50160287.eng.abstr
[ { "id": "DerPathologe.50160287.eng.abstr-passage-0", "type": "abstract", "text": [ "Embryonal rhabdomyosarcomas of the female genital tract usually occur during infancy in the vagina . Only in rare cases can they be found in the cervix , where they are most commonly seen in adolescence . Their prognosis seems to be good since the introduction of a combination of surgery and chemotherapy . We report a case of cervical embryonal rhabdomysarcoma in IRS stage Ia in a 32-year-old female . After surgical resection and chemotherapy there has been no evidence of disease for 7 months . The case is compared with the published literature and prognostically relevant features , and possible problems in the differential diagnosis in biopsies are discussed ." ], "offsets": [ [ 0, 669 ] ] } ]
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[]
[]
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DerPathologe.50160292.eng.abstr
DerPathologe.50160292.eng.abstr
[ { "id": "DerPathologe.50160292.eng.abstr-passage-0", "type": "abstract", "text": [ "Lung cysts were observed by chance in the chest radiographs from two women aged 20 and 41. In the surgical specimens the lesions proved to be congenital cystic adenomatoid malformation type 1. The cysts were partially lined by mucous cells . Also near the cysts there were circumscribed tubuloacinar proliferations of mucous cells . In both cases a transition into a bronchioloalveolar carcinoma was seen . Histochemically no sulphomucins could be demonstrated by means of an alcian blue pH 1 reaction in the tumor cells , but was demonstrated in the non-neoplastic cells of the malformation . In both cases CEA was demonstrated in the tumor cells . Some cells in the tubuloacinar proliferations were weakly CEA positive . In one patient the diagnosis of carcinoma was made by intraoperative frozen section and a lobectomy was performed . The other patient had first only a resection of her cystic lesions and had to be reoperated because of the results of the pathological examination . Both patients had no recurrence in the 8 years following the operation . In the literature we found 5 cases of congenital cystic adenomatoid malformation in adults . In 2 cases there was also an associated bronchioloalveolar carcinoma . Several reports exist on the association of different kinds of cystic lung lesions and malignant tumors and their possible pathogenetic relationship . In this paper we draw attention to the development of malignant neoplasia in congenital cystic adenomatoid malformation in adults and its diagnostic problems ." ], "offsets": [ [ 0, 1535 ] ] } ]
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"normalized": [ { "db_name": "UMLS", "db_id": "C0010709" } ] }, { "id": "DerPathologe.50160292.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "mucous" ], "offsets": [ [ 318, 324 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026727" } ] }, { "id": "DerPathologe.50160292.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "cells" ], "offsets": [ [ 325, 330 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "DerPathologe.50160292.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "carcinoma" ], "offsets": [ [ 386, 395 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007097" } ] }, { "id": "DerPathologe.50160292.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "bronchioloalveolar carcinoma" ], "offsets": [ [ 367, 395 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007120" } ] }, { "id": "DerPathologe.50160292.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "sulphomucins" ], "offsets": [ [ 426, 438 ] ], "normalized": [ { "db_name": "UMLS", "db_id": 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DerPathologe.50160307.eng.abstr
DerPathologe.50160307.eng.abstr
[ { "id": "DerPathologe.50160307.eng.abstr-passage-0", "type": "abstract", "text": [ "The aim of morphological tumour diagnosis is to answer clinical questions on type , biological potential , prognosis and aetiology of individual neoplasms . The limitations and perspectives of different methods used in the diagnosis of adrenal tumours , ranging from histology to molecular genetic DNA analyses , are described . When surgical specimens from adrenal neoplasms cannot be typed on the basis of histology and/or with clinica data ( e . g . , endocrine symptoms and history ) as adrenocortical tumours , phaeochromocytomas or metastases to the adrenal , immunohistological investigations with a panel of different antibodies are necessary . After identification of the tissue derivation of an individual adrenal tumour , its biological potential must be assessed . Among adrenocortical neoplasms , adenomas and carcinomas can be distinguished by evaluation of various histological parameters ( including structural features and signs of invasion ) according to defined algorithms . In addition , conventional histology ( by estimation of mitotic activity ) allows the discrimination of tumours with especially high malignant potential from other adrenocortical carcinomas . In contrast , among adrenomedullary tumours even the combined use of histological , immunohistological and DNA cytophotometric techniques only allows the definition of risk groups ( benign versus suggestive of malignancy ) , while reliable recognition of an individual malignant phaeochromocytoma is so far impossible . The question as to whether a particular phaeochromocytoma represents a sporadic tumour or a neoplasm inherited as one feature of a defined syndrome cannot be answered with the above methods , but only by the application of molecular genetic techniques ." ], "offsets": [ [ 0, 1759 ] ] } ]
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DerPathologe.50160321.eng.abstr
DerPathologe.50160321.eng.abstr
[ { "id": "DerPathologe.50160321.eng.abstr-passage-0", "type": "abstract", "text": [ "von Hippel-Lindau ( VHL ) disease is an autosomal dominant heritable disease that often occurs in association with various benign and malignant tumours . Clinically the disease is classified as VHL 1 ( without phaeochromocytoma ) and VHL 2 ( with phaeochromocytoma ) . Genetically , VHL is caused by germline mutations in the VHL tumour suppressor gene . More than 100 germline mutations and rearrangements have been identified , but the biological function of a hypothetical VHL protein is not yet known . Genotype-phenotype correlations should aid in the understanding of this biological role . All VHL manifestations subsequently develop to VHL mutations , but some mutations may act in a tissue-specific manner . Whereas missense mutations cause tumour suppression to fail in adrenal cells , more severe structural mutations are usually necessary for tumour development in renal cells . As predicted by the tumour suppressor theory , the VHL gene also plays a critical part in the pathogenesis of sporadic non-VHL-associated tumours . In a large number of sporadic renal clear cell carcinomas , mutations and hypermethylation cause inactivation of the VHL gene . Together with allelic 3 p loss , these constitute rate-limiting events in renal tumourigenesis . Insights into the molecular basis of phenotypic variability in VHL disease and the confirmation of the tumour-suppressor criteria in VHL and non-VHL sporadic tumours indicate an important role of the VHL gene in the development of these tumours ." ], "offsets": [ [ 0, 1510 ] ] } ]
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DerPathologe.50160328.eng.abstr
DerPathologe.50160328.eng.abstr
[ { "id": "DerPathologe.50160328.eng.abstr-passage-0", "type": "abstract", "text": [ "The malignant B-cell lymphoma of the MALT-type shows significant differences from nodal lymphomas with respect to its biological , molecular genetic , and clinical properties . According to the proposal from the International Lymphoma Study Group for a Revised European-American Classification of Lymphoid Neoplasms , MALT-B-cell lymphomas have been defined as an extranodal subgroup of marginal zone B-cell lymphomas and may have lower and higher grade types . We have applied this classification to 24 cases of primary B-cell lymphomas of the lung . These tumors showed histopathologic features of low ( n = 20 ) and/or high grade neoplasms ( n = 4 ) recapitulating the structure of the acquired bronchus- associated lymphoid tissue ( BALT ) . According to our experience , the diagnosis of BALT-type B-cell lymphoma , is both practically feasable and reproducible not only for surgical material but even for biopsy specimens ." ], "offsets": [ [ 0, 929 ] ] } ]
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"B-cell lymphoma" ], "offsets": [ [ 14, 29 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0079731" } ] }, { "id": "DerPathologe.50160328.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "molecular genetic" ], "offsets": [ [ 131, 148 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086345" } ] }, { "id": "DerPathologe.50160328.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "Lymphoma" ], "offsets": [ [ 226, 234 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024299" } ] }, { "id": "DerPathologe.50160328.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "Classification" ], "offsets": [ [ 279, 293 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008902" }, { "db_name": "UMLS", "db_id": "C0008903" } ] }, { "id": "DerPathologe.50160328.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "Neoplasms" ], "offsets": [ [ 306, 315 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" }, { "db_name": "UMLS", "db_id": "C0036210" } ] }, { "id": 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[]
[]
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DerPathologe.50160336.eng.abstr
DerPathologe.50160336.eng.abstr
[ { "id": "DerPathologe.50160336.eng.abstr-passage-0", "type": "abstract", "text": [ "Recanalisation of the carotid sinus is one of the most frequently performed vascular interventions ; endarterectomy of the coronary arteries is an auxiliary measure accompanying aortocoronary bypass . Enucleation of the sclerotic plaque is followed by reconstruction of the intima and by rapid smoothing over of the \" steps \" along the side of the recanalised segment by proliferation of smooth muscle cells from the remaining media . The thinner the residual media , the thicker grows the neointima . Occasionally elastic lamellae reminiscent of a lamina elastica interna are formed close to the lumen . Moreover , in some cases renewed formation of the characteristic intimal spur ( fibrotic ridge ) is seen at the carotid sinus inlet , a sign of continued irregularity of blood flow postoperatively . In contrast , no focal lesions are generally observed in recanalised segments in the coronary arteries . New sclerotic pads that occur in the late phase bear a morphological resemblance to those in operated restenoses . The distribution of these pads is largely congruent with that of the sclerotic plaques in non-operated cervical arteries . Thus , even when recanalisation of the carotid sinus is uncomplicated , reparative processes are followed by the re-formation of sclerotic pads , largely determined by haemodynamic factors . In the coronary arteries , concentric rather than focal sclerotic lesions predominate ." ], "offsets": [ [ 0, 1425 ] ] } ]
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[]
[]
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DerPathologe.50160342.eng.abstr
DerPathologe.50160342.eng.abstr
[ { "id": "DerPathologe.50160342.eng.abstr-passage-0", "type": "abstract", "text": [ "The combined histological and microcomputed analysis of human iliac crest biopsies leads to major advances in our understanding of three-dimensional bone architecture . Microcomputed tomography avoids the time-consuming reconstruction and artifacts of serial sections . Furthermore , its high resolution allows the recording of structural differences as low as 10 mm . Thus , three-dimensional analysis in combination with histological evaluation of cellular dynamics facilitates earlier and easier recording of changes of cancellous bone ." ], "offsets": [ [ 0, 540 ] ] } ]
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DerPathologe.50160348.eng.abstr
DerPathologe.50160348.eng.abstr
[ { "id": "DerPathologe.50160348.eng.abstr-passage-0", "type": "abstract", "text": [ "A 54-year-old female patient with a 10-year history of ventriculoperitoneal shunt resulting from communicating hydrocephalus of undetermined aetiology is reported . Transient gait disturbances and cerebral infarction at the age of 46 did not lead to further insights into the nature of the disease . After many years with only occasional disturbances , a distinct organic brain syndrome developed . Thorough examination led to a tentative diagnosis of neurocysticercosis ; this was based on the history , liquor diagnosis and cerebral microcalcifications in CT . Despite the initiation of specific therapy , the patient died of the sequelae of the disease . At autopsy , characteristic cicatricial residues of mainly basal leptomeningitis were found with collapsed parasitic cysts . Additional intracerebral mesenchymal-glial reactions were less conspicuous . Residual ependymitis had caused aqueductal stenosis . Death was due to cachexia , bronchopneumonia and a lung abscess . The clinical course and morphology of neurocysticercosis are discussed . The disease has become rare in our country , but is globally the most important parasitic disease of the central nervous system ." ], "offsets": [ [ 0, 1182 ] ] } ]
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DerPathologe.50160354.eng.abstr
DerPathologe.50160354.eng.abstr
[ { "id": "DerPathologe.50160354.eng.abstr-passage-0", "type": "abstract", "text": [ "A 59-year-old male patient was transnasally operated on because of a pituitary adenoma with hypopituitarism . A second operation and X-ray therapy followed a half year later due to recurrent tumor . Both neoplasmas were classified as sparsely granulated prolactin cell adenomas . Immunohistochemical studies revealed strong immunoreactivity for prolactin and FSH in the tumor cells of both the pituitary adenoma and the recurrent tumor . Two years later the prolactin plasma levels were extremely elevated . A tumor in the liver was identified . Biopsy revealed a solid endocrine tumor containing prolactin by immunohistology . Due to structural and immunohistological similarities this tumor could be identified as a metastasis of the pituitary tumor . After 5 months of therapy the patient died from thrombembolism . Post-mortem studies confirmed the diagnosis of a metastasizing prolactin-secreting pituitary carcinoma . Only six similar cases have been reported in the literature . Our case report confirms the experience with 35 definite pituitary carcinomas reparted in the current literature : malignant pituitary tumors develop after pituitary surgery and can be identified not from the pituitary tumor , but only from its metastases ." ], "offsets": [ [ 0, 1243 ] ] } ]
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[]
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DerPathologe.50160359.eng.abstr
DerPathologe.50160359.eng.abstr
[ { "id": "DerPathologe.50160359.eng.abstr-passage-0", "type": "abstract", "text": [ "We report the case of an ectopic hamartomatous thymoma in a 56-year-old male patient . The lesion arose subcutaneously in the supraclavicular region . Histologically , the well-circumscribed but unencapsulated tumour was composed of uniform fusiform tumour cells . In addition , mature fatty tissue , scattered T-lymphocytes , and an epithelial and a myoepithelial tumour cell component were found . The epithelial differentiation of the spindle cell tumour component was confirmed immunohistochemically and by electron microscopy . Ectopic hamartomatous thymoma has to be distinguished from ectopic cervical thymoma , thymolipoma , ectopic salivary tissue , teratoma , peripheral nerve sheath tumours , malignant epithelial tumours with thymus-like differentiation , biphasic synovial sarcoma , and skin adnexal tumours ." ], "offsets": [ [ 0, 822 ] ] } ]
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"DerPathologe.50160359.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "tumour" ], "offsets": [ [ 250, 256 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.50160359.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "cells" ], "offsets": [ [ 257, 262 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "DerPathologe.50160359.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "tissue" ], "offsets": [ [ 292, 298 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040300" } ] }, { "id": "DerPathologe.50160359.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "tumour" ], "offsets": [ [ 365, 371 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.50160359.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "cell" ], "offsets": [ [ 372, 376 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "DerPathologe.50160359.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "fatty tissue" ], "offsets": [ [ 286, 298 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001527" } ] }, { "id": "DerPathologe.50160359.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "myoepithelial tumour" ], "offsets": [ [ 351, 371 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027070" } ] }, { "id": "DerPathologe.50160359.eng.abstr-s4-t6", "type": "umlsterm", "text": [ "cell component" ], "offsets": [ [ 372, 386 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243092" } ] }, { "id": "DerPathologe.50160359.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "cell" ], "offsets": [ [ 446, 450 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "DerPathologe.50160359.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "tumour" ], "offsets": [ [ 451, 457 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.50160359.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "electron" ], "offsets": [ [ 511, 519 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013852" } ] }, { "id": "DerPathologe.50160359.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "microscopy" ], "offsets": [ [ 520, 530 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026018" } ] }, { "id": "DerPathologe.50160359.eng.abstr-s5-t5", "type": "umlsterm", "text": [ "electron microscopy" ], "offsets": [ [ 511, 530 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026019" } ] }, { "id": "DerPathologe.50160359.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "Ectopic" ], "offsets": [ [ 533, 540 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015374" } ] }, { "id": "DerPathologe.50160359.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "thymoma" ], "offsets": [ [ 555, 562 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040100" } ] }, { "id": "DerPathologe.50160359.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "ectopic" ], "offsets": [ [ 592, 599 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015374" } ] }, { "id": "DerPathologe.50160359.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "thymoma" ], "offsets": [ [ 609, 616 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040100" } ] }, { "id": "DerPathologe.50160359.eng.abstr-s6-t5", "type": "umlsterm", "text": [ "thymolipoma" ], "offsets": [ [ 619, 630 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040096" } ] }, { "id": "DerPathologe.50160359.eng.abstr-s6-t6", "type": "umlsterm", "text": [ "ectopic" ], "offsets": [ [ 633, 640 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015374" } ] }, { "id": "DerPathologe.50160359.eng.abstr-s6-t7", "type": "umlsterm", "text": [ "tissue" ], "offsets": [ [ 650, 656 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040300" } ] }, { "id": "DerPathologe.50160359.eng.abstr-s6-t8", "type": "umlsterm", "text": [ "teratoma" ], "offsets": [ [ 659, 667 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039538" } ] }, { "id": "DerPathologe.50160359.eng.abstr-s6-t9", "type": "umlsterm", "text": [ "nerve" ], "offsets": [ [ 681, 686 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027769" } ] }, { "id": "DerPathologe.50160359.eng.abstr-s6-t10", "type": "umlsterm", "text": [ "tumours" ], "offsets": [ [ 694, 701 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.50160359.eng.abstr-s6-t11", "type": "umlsterm", "text": [ "malignant" ], "offsets": [ [ 704, 713 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006826" } ] }, { "id": "DerPathologe.50160359.eng.abstr-s6-t12", "type": "umlsterm", "text": [ "tumours" ], "offsets": [ [ 725, 732 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.50160359.eng.abstr-s6-t13", "type": "umlsterm", "text": [ "thymus-like" ], "offsets": [ [ 738, 749 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040113" } ] }, { "id": "DerPathologe.50160359.eng.abstr-s6-t14", "type": "umlsterm", "text": [ "sarcoma" ], "offsets": [ [ 786, 793 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036210" } ] }, { "id": "DerPathologe.50160359.eng.abstr-s6-t15", "type": "umlsterm", "text": [ "skin" ], "offsets": [ [ 800, 804 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] }, { "id": "DerPathologe.50160359.eng.abstr-s6-t16", "type": "umlsterm", "text": [ "tumours" ], "offsets": [ [ 813, 820 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.50160359.eng.abstr-s6-t17", "type": "umlsterm", "text": [ "peripheral nerve" ], "offsets": [ [ 670, 686 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031119" } ] }, { "id": "DerPathologe.50160359.eng.abstr-s6-t18", "type": "umlsterm", "text": [ "epithelial tumours" ], "offsets": [ [ 714, 732 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0205853" } ] }, { "id": "DerPathologe.50160359.eng.abstr-s6-t19", "type": "umlsterm", "text": [ "synovial sarcoma" ], "offsets": [ [ 777, 793 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039101" } ] }, { "id": "DerPathologe.50160359.eng.abstr-s6-t20", "type": "umlsterm", "text": [ "nerve sheath tumours" ], "offsets": [ [ 681, 701 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0206727" } ] }, { "id": "DerPathologe.50160359.eng.abstr-s6-t21", "type": "umlsterm", "text": [ "malignant epithelial tumours" ], "offsets": [ [ 704, 732 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007097" } ] } ]
[]
[]
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DerPathologe.50160386.eng.abstr
DerPathologe.50160386.eng.abstr
[ { "id": "DerPathologe.50160386.eng.abstr-passage-0", "type": "abstract", "text": [ "Primary thrombosis and phlebitis with secondary thrombosis of superficial veins are frequent . A biopsy may be performed if the clinician suspects an underlying systemic disease . The pathologist must be aware of the different types and their etiology because the further diagnostic and therapeutic procedures depend on his evaluation . The different types of primary thrombotic and primary phlebitic disorders are described and their possible etiology is discussed ." ], "offsets": [ [ 0, 467 ] ] } ]
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[]
[]
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DerPathologe.50160391.eng.abstr
DerPathologe.50160391.eng.abstr
[ { "id": "DerPathologe.50160391.eng.abstr-passage-0", "type": "abstract", "text": [ "The documentation form for pathohistologic findings ( version III ) for tumors of the maxillofacial region is presented . It is part of the site-specific documentation of the German Association of Tumor Centers ( ADT ) . Its handling is explained by instructions which are based on the ICD-O classification and the TNM system . The prognostic relevance of the standardized documentation has already been proven by various histomorphologic investigations concerning oral and oropharyngeal cancer . By means of a multicentric observational study the German Austrian Swiss co-operative group DOeSAK will develop a new prognostic model for oral and oropharyngeal cancer ." ], "offsets": [ [ 0, 667 ] ] } ]
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[]
[]
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DerPathologe.50160404.eng.abstr
DerPathologe.50160404.eng.abstr
[ { "id": "DerPathologe.50160404.eng.abstr-passage-0", "type": "abstract", "text": [ "Nerve fibre-neuroendocrine cell complexes ( NF-NEC-C's ) are neuroendocrine cells located in the lamina propria of the gastrointestinal tract directly connected with nerve fibres of Meissner's plexus . We report on a patient with sporadic Zollinger-Ellison syndrome ( ZES ) with electron microscopically demonstrated multiple NF-NEC-C's in non-antral gastric mucosa . It is suspected that in ZES the hypergastrinaemia may represent a trophic stimulus for the proliferation of NF-NEC-C's in the gastric mucosa ." ], "offsets": [ [ 0, 510 ] ] } ]
[ { "id": "DerPathologe.50160404.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Nerve" ], "offsets": [ [ 0, 5 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027769" } ] }, { "id": "DerPathologe.50160404.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "cell" ], "offsets": [ [ 27, 31 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "DerPathologe.50160404.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "cells" ], "offsets": [ [ 76, 81 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "DerPathologe.50160404.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "lamina" ], "offsets": [ [ 97, 103 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0064635" } ] }, { "id": "DerPathologe.50160404.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "nerve" ], "offsets": [ [ 166, 171 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027769" } ] }, { "id": "DerPathologe.50160404.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 217, 224 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerPathologe.50160404.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "syndrome" ], "offsets": [ [ 257, 265 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "DerPathologe.50160404.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "electron" ], "offsets": [ [ 279, 287 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013852" } ] }, { "id": "DerPathologe.50160404.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "non-antral" ], "offsets": [ [ 340, 350 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0293352" } ] }, { "id": "DerPathologe.50160404.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "mucosa" ], "offsets": [ [ 359, 365 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026724" } ] }, { "id": "DerPathologe.50160404.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "Zollinger-Ellison syndrome" ], "offsets": [ [ 239, 265 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043515" } ] }, { "id": "DerPathologe.50160404.eng.abstr-s2-t7", "type": "umlsterm", "text": [ "gastric mucosa" ], "offsets": [ [ 351, 365 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017136" } ] }, { "id": "DerPathologe.50160404.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "mucosa" ], "offsets": [ [ 502, 508 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026724" } ] }, { "id": "DerPathologe.50160404.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "gastric mucosa" ], "offsets": [ [ 494, 508 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017136" } ] } ]
[]
[]
[ { "id": "DerPathologe.50160404.eng.abstr-s1-r1-t5.1-t4.1", "type": "produces", "arg1_id": "DerPathologe.50160404.eng.abstr-s2-t5", "arg2_id": "DerPathologe.50160404.eng.abstr-s2-t4", "normalized": [] }, { "id": "DerPathologe.50160404.eng.abstr-s1-r2-t1.1-t4.1", "type": "produces", "arg1_id": "DerPathologe.50160404.eng.abstr-s3-t1", "arg2_id": "DerPathologe.50160404.eng.abstr-s2-t4", "normalized": [] }, { "id": "DerPathologe.50160404.eng.abstr-s1-r3-t4.1-t1.1", "type": "affects", "arg1_id": "DerPathologe.50160404.eng.abstr-s2-t4", "arg2_id": "DerPathologe.50160404.eng.abstr-s3-t1", "normalized": [] }, { "id": "DerPathologe.50160404.eng.abstr-s1-r4-t3.1-t5.1", "type": "location_of", "arg1_id": "DerPathologe.50160404.eng.abstr-s2-t3", "arg2_id": "DerPathologe.50160404.eng.abstr-s2-t5", "normalized": [] }, { "id": "DerPathologe.50160404.eng.abstr-s1-r5-t4.1-t3.1", "type": "disrupts", "arg1_id": "DerPathologe.50160404.eng.abstr-s2-t4", "arg2_id": "DerPathologe.50160404.eng.abstr-s2-t3", "normalized": [] }, { "id": "DerPathologe.50160404.eng.abstr-s1-r6-t1.1-t5.1", "type": "location_of", "arg1_id": "DerPathologe.50160404.eng.abstr-s3-t1", "arg2_id": "DerPathologe.50160404.eng.abstr-s2-t5", "normalized": [] }, { "id": "DerPathologe.50160404.eng.abstr-s1-r7-t4.1-t1.1", "type": "disrupts", "arg1_id": "DerPathologe.50160404.eng.abstr-s2-t4", "arg2_id": "DerPathologe.50160404.eng.abstr-s3-t1", "normalized": [] }, { "id": "DerPathologe.50160404.eng.abstr-s1-r8-t1.1-t5.1", "type": "evaluation_of", "arg1_id": "DerPathologe.50160404.eng.abstr-s3-t1", "arg2_id": "DerPathologe.50160404.eng.abstr-s2-t5", "normalized": [] }, { "id": "DerPathologe.50160404.eng.abstr-s1-r9-t3.1-t4.1", "type": "produces", "arg1_id": "DerPathologe.50160404.eng.abstr-s2-t3", "arg2_id": "DerPathologe.50160404.eng.abstr-s2-t4", "normalized": [] }, { "id": "DerPathologe.50160404.eng.abstr-s1-r10-t4.1-t5.1", "type": "affects", "arg1_id": "DerPathologe.50160404.eng.abstr-s2-t4", "arg2_id": "DerPathologe.50160404.eng.abstr-s2-t5", "normalized": [] }, { "id": "DerPathologe.50160404.eng.abstr-s1-r11-t3.1-t1.1", "type": "location_of", "arg1_id": "DerPathologe.50160404.eng.abstr-s2-t3", "arg2_id": "DerPathologe.50160404.eng.abstr-s3-t1", "normalized": [] }, { "id": "DerPathologe.50160404.eng.abstr-s1-r12-t5.1-t1.1", "type": "evaluation_of", "arg1_id": "DerPathologe.50160404.eng.abstr-s2-t5", "arg2_id": "DerPathologe.50160404.eng.abstr-s3-t1", "normalized": [] }, { "id": "DerPathologe.50160404.eng.abstr-s2-r1-t4.1-t6.1", "type": "diagnoses", "arg1_id": "DerPathologe.50160404.eng.abstr-s2-t4", "arg2_id": "DerPathologe.50160404.eng.abstr-s2-t6", "normalized": [] }, { "id": "DerPathologe.50160404.eng.abstr-s2-r2-t4.1-t2.1", "type": "diagnoses", "arg1_id": "DerPathologe.50160404.eng.abstr-s2-t4", "arg2_id": "DerPathologe.50160404.eng.abstr-s3-t2", "normalized": [] }, { "id": "DerPathologe.50160404.eng.abstr-s2-r3-t4.1-t7.1", "type": "disrupts", "arg1_id": "DerPathologe.50160404.eng.abstr-s2-t4", "arg2_id": "DerPathologe.50160404.eng.abstr-s2-t7", "normalized": [] }, { "id": "DerPathologe.50160404.eng.abstr-s2-r4-t7.1-t2.1", "type": "location_of", "arg1_id": "DerPathologe.50160404.eng.abstr-s2-t7", "arg2_id": "DerPathologe.50160404.eng.abstr-s3-t2", "normalized": [] }, { "id": "DerPathologe.50160404.eng.abstr-s2-r5-t2.1-t1.1", "type": "occurs_in", "arg1_id": "DerPathologe.50160404.eng.abstr-s3-t2", "arg2_id": "DerPathologe.50160404.eng.abstr-s3-t1", "normalized": [] }, { "id": "DerPathologe.50160404.eng.abstr-s2-r6-t6.1-t4.1", "type": "produces", "arg1_id": "DerPathologe.50160404.eng.abstr-s2-t6", "arg2_id": "DerPathologe.50160404.eng.abstr-s2-t4", "normalized": [] }, { "id": "DerPathologe.50160404.eng.abstr-s2-r7-t7.1-t4.1", "type": "produces", "arg1_id": "DerPathologe.50160404.eng.abstr-s2-t7", "arg2_id": "DerPathologe.50160404.eng.abstr-s2-t4", "normalized": [] }, { "id": "DerPathologe.50160404.eng.abstr-s2-r8-t7.1-t6.1", "type": 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"normalized": [] }, { "id": "DerPathologe.50160404.eng.abstr-s2-r18-t2.1-t7.1", "type": "produces", "arg1_id": "DerPathologe.50160404.eng.abstr-s3-t2", "arg2_id": "DerPathologe.50160404.eng.abstr-s2-t7", "normalized": [] } ]
DerPathologe.50160408.eng.abstr
DerPathologe.50160408.eng.abstr
[ { "id": "DerPathologe.50160408.eng.abstr-passage-0", "type": "abstract", "text": [ "Resection of a stenosing colon tumor in an 89-year-old male patient led to the diagnosis , unusual at this age , of an inflammatory pseudotumor ( synonym : plasma cell granuloma ) of the retroperitoneum and mesentery , which invaded the large bowel and showed infiltration of one regional lymph node . Histology and immunohistochemistry ( demonstrating a myofibroblastic phenotype of the proliferating spindle cells and polyclonality of abundantly present plasma cells ) of the specimen resembled previously reported lesions in various locations . The etiology and exact nosological classification of inflammatory pseudotumors are not yet unequivocally settled . The recently published conjecture that such lesions of the retroperitoneum represent a separate entity with features of a malignant neoplasm is discussed ." ], "offsets": [ [ 0, 818 ] ] } ]
[ { "id": "DerPathologe.50160408.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "colon" ], "offsets": [ [ 25, 30 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007102" }, { "db_name": "UMLS", "db_id": "C0009368" } ] }, { "id": "DerPathologe.50160408.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "tumor" ], "offsets": [ [ 31, 36 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.50160408.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "male" ], "offsets": [ [ 55, 59 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024554" }, { "db_name": "UMLS", "db_id": "C0086582" } ] }, { "id": "DerPathologe.50160408.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 60, 67 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerPathologe.50160408.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "diagnosis" ], "offsets": [ [ 79, 88 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011900" }, { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerPathologe.50160408.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "age" ], "offsets": [ [ 107, 110 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001792" }, { "db_name": "UMLS", "db_id": "C0001811" } ] }, { "id": "DerPathologe.50160408.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "plasma" ], "offsets": [ [ 156, 162 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032105" } ] }, { "id": "DerPathologe.50160408.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "cell" ], "offsets": [ [ 163, 167 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "DerPathologe.50160408.eng.abstr-s1-t9", "type": "umlsterm", "text": [ "granuloma" ], "offsets": [ [ 168, 177 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018188" } ] }, { "id": "DerPathologe.50160408.eng.abstr-s1-t10", "type": "umlsterm", "text": [ "retroperitoneum" ], "offsets": [ [ 187, 202 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035359" } ] }, { "id": "DerPathologe.50160408.eng.abstr-s1-t11", "type": "umlsterm", "text": [ "mesentery" ], "offsets": [ [ 207, 216 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025474" } ] }, { "id": "DerPathologe.50160408.eng.abstr-s1-t12", "type": "umlsterm", "text": [ "bowel" ], "offsets": [ [ 243, 248 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021853" } ] }, { "id": "DerPathologe.50160408.eng.abstr-s1-t13", "type": "umlsterm", "text": [ "lymph" ], "offsets": [ [ 289, 294 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024202" } ] }, { "id": "DerPathologe.50160408.eng.abstr-s1-t14", "type": "umlsterm", "text": [ "colon tumor" ], "offsets": [ [ 25, 36 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009375" } ] }, { "id": "DerPathologe.50160408.eng.abstr-s1-t15", "type": "umlsterm", "text": [ "inflammatory pseudotumor" ], "offsets": [ [ 119, 143 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0334121" } ] }, { "id": "DerPathologe.50160408.eng.abstr-s1-t16", "type": "umlsterm", "text": [ "plasma cell" ], "offsets": [ [ 156, 167 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032112" } ] }, { "id": "DerPathologe.50160408.eng.abstr-s1-t17", "type": "umlsterm", "text": [ "large bowel" ], "offsets": [ [ 237, 248 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021851" } ] }, { "id": "DerPathologe.50160408.eng.abstr-s1-t18", "type": "umlsterm", "text": [ "lymph node" ], "offsets": [ [ 289, 299 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024204" } ] }, { "id": "DerPathologe.50160408.eng.abstr-s1-t19", "type": "umlsterm", "text": [ "plasma cell granuloma" ], "offsets": [ [ 156, 177 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018199" } ] }, { "id": "DerPathologe.50160408.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "Histology" ], "offsets": [ [ 302, 311 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019638" }, { "db_name": "UMLS", "db_id": "C0205462" } ] }, { "id": "DerPathologe.50160408.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "immunohistochemistry" ], "offsets": [ [ 316, 336 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021044" } ] }, { "id": "DerPathologe.50160408.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "cells" ], "offsets": [ [ 410, 415 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "DerPathologe.50160408.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "plasma" ], "offsets": [ [ 456, 462 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032105" } ] }, { "id": "DerPathologe.50160408.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "cells" ], "offsets": [ [ 463, 468 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "DerPathologe.50160408.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "plasma cells" ], "offsets": [ [ 456, 468 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032112" } ] }, { "id": "DerPathologe.50160408.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "etiology" ], "offsets": [ [ 552, 560 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015127" }, { "db_name": "UMLS", "db_id": "C0007463" } ] }, { "id": "DerPathologe.50160408.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "exact" ], "offsets": [ [ 565, 570 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0059927" } ] }, { "id": "DerPathologe.50160408.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "classification" ], "offsets": [ [ 583, 597 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008902" }, { "db_name": "UMLS", "db_id": "C0008903" } ] }, { "id": "DerPathologe.50160408.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "inflammatory pseudotumors" ], "offsets": [ [ 601, 626 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0334121" } ] }, { "id": "DerPathologe.50160408.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "retroperitoneum" ], "offsets": [ [ 722, 737 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035359" } ] }, { "id": "DerPathologe.50160408.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "separate" ], "offsets": [ [ 750, 758 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086972" } ] }, { "id": "DerPathologe.50160408.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "malignant" ], "offsets": [ [ 785, 794 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006826" } ] }, { "id": "DerPathologe.50160408.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "neoplasm" ], "offsets": [ [ 795, 803 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" }, { "db_name": "UMLS", "db_id": "C0036210" } ] }, { "id": "DerPathologe.50160408.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "malignant neoplasm" ], "offsets": [ [ 785, 803 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006826" } ] } ]
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DerPathologe.50160415.eng.abstr
DerPathologe.50160415.eng.abstr
[ { "id": "DerPathologe.50160415.eng.abstr-passage-0", "type": "abstract", "text": [ "Inflammatory pseudotumors of the liver are extremely rare . Worldwide only 50 cases have been described so far . In lung tissue , their incidence is higher , with 119 cases being published . Etiological factors are still a matter of debate ; reactive inflammatory processes have recently been proved by immunohistological and cytophotometric studies . This seems to be true for both liver and lung locations of inflammatory pseudotumors . Considerable morphological heterogeneities , conspicuously varying from one case to another , reflect the numerous synonyms that have been created for this condition , i . e . , plasma cell granuloma , xanthoma , fibroxanthoma , histiocytoma , plasmacytoma , solitary \" mast cell tumor \" and pseudoneoplastic pneumonia , just to number a few of them . This multicolored morphology explains the difficulties in histologic diagnosis , especially if needle biopsies or frozen sections are submitted to pathology . Differential diagnosis of an inflammatory pseudotumor of the liver needs to include fibrohistiocytic neoplasia if spindle-cell-shaped areas are included or , on the other hand , parenchymal infiltrates of the nodular sclerosing type of Hodgkin's granuloma . Immunohistological investigations do not allow final decisions since spindle-shaped cells within pseudotumours can express vimentin and/or desmin as well . Such histological cases should always include the excision of a piece of liver tissue of sufficient size to comfortably allow for the recognition of the mutlicellular composition and morphological heterogeneity of this process ." ], "offsets": [ [ 0, 1592 ] ] } ]
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"DerPathologe.50160415.eng.abstr-s12-r5-t2.1-t1.1", "type": "developmental_form_of", "arg1_id": "DerPathologe.50160415.eng.abstr-s12-t2", "arg2_id": "DerPathologe.50160415.eng.abstr-s12-t1", "normalized": [] }, { "id": "DerPathologe.50160415.eng.abstr-s12-r6-t3.1-t1.1", "type": "result_of", "arg1_id": "DerPathologe.50160415.eng.abstr-s12-t3", "arg2_id": "DerPathologe.50160415.eng.abstr-s12-t1", "normalized": [] }, { "id": "DerPathologe.50160415.eng.abstr-s12-r7-t1.1-t2.1", "type": "produces", "arg1_id": "DerPathologe.50160415.eng.abstr-s12-t1", "arg2_id": "DerPathologe.50160415.eng.abstr-s12-t2", "normalized": [] }, { "id": "DerPathologe.50160415.eng.abstr-s12-r8-t2.1-t1.1", "type": "location_of", "arg1_id": "DerPathologe.50160415.eng.abstr-s12-t2", "arg2_id": "DerPathologe.50160415.eng.abstr-s12-t1", "normalized": [] }, { "id": "DerPathologe.50160415.eng.abstr-s12-r9-t4.1-t3.1", "type": "result_of", "arg1_id": "DerPathologe.50160415.eng.abstr-s12-t4", "arg2_id": "DerPathologe.50160415.eng.abstr-s12-t3", "normalized": [] } ]
DerPathologe.50160421.eng.abstr
DerPathologe.50160421.eng.abstr
[ { "id": "DerPathologe.50160421.eng.abstr-passage-0", "type": "abstract", "text": [ "Uterine tumors resembling sex-cord ovarian structures are exceptionally rare . Clement and Scully divided them into two groups . The first group includes cases with less than 50 % and the second with more than 50 % sex-cord elements . Group one tumors show a higher incidence of recurrences . We report a case of a 54-year-old women with a partly retroperitoneal , cystic tumor 7 - 6 - 6 cm . Histologically , sex-cord differentiation of more than 50 % was seen with positive immunostaining against vimentin , desmin and focally against myoglobin and cytokeratines . The reaction against EMA , CEA and S 100 was negative . The patient was treated by abdominal hysterectomy with bilateral salpingo-oovorectomy . She shows no evidence of disease 2.3 years after the initial surgery . Based on the light microscopic features and immunohistochemical pattern , the tumor was interpreted as arising from the endometrial stromal cells or multipotential uterine mesenchyme that showed diverse differentiation toward ovarian sex-cord stroma and uterine smooth muscle with interspersed stromal cell clusters ." ], "offsets": [ [ 0, 1099 ] ] } ]
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"C0021149" } ] }, { "id": "DerPathologe.50160421.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "recurrences" ], "offsets": [ [ 279, 290 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034897" } ] }, { "id": "DerPathologe.50160421.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "women" ], "offsets": [ [ 327, 332 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043210" } ] }, { "id": "DerPathologe.50160421.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "tumor" ], "offsets": [ [ 372, 377 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.50160421.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "sex-cord" ], "offsets": [ [ 410, 418 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0079399" }, { "db_name": "UMLS", "db_id": "C0009253" } ] }, { "id": "DerPathologe.50160421.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "vimentin" ], "offsets": [ [ 499, 507 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042666" } ] }, { "id": "DerPathologe.50160421.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "desmin" ], "offsets": [ [ 510, 516 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011696" } ] }, { "id": "DerPathologe.50160421.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "myoglobin" ], "offsets": [ [ 537, 546 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027078" } ] }, { "id": "DerPathologe.50160421.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "CEA" ], "offsets": [ [ 594, 597 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007082" } ] }, { "id": "DerPathologe.50160421.eng.abstr-s8-t1", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 627, 634 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerPathologe.50160421.eng.abstr-s8-t2", "type": "umlsterm", "text": [ "hysterectomy" ], "offsets": [ [ 660, 672 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020699" } ] }, { "id": "DerPathologe.50160421.eng.abstr-s9-t1", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 736, 743 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerPathologe.50160421.eng.abstr-s9-t2", "type": "umlsterm", "text": [ "surgery" ], "offsets": [ [ 772, 779 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038894" }, { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "DerPathologe.50160421.eng.abstr-s10-t1", "type": "umlsterm", "text": [ "light" ], "offsets": [ [ 795, 800 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023693" } ] }, { "id": "DerPathologe.50160421.eng.abstr-s10-t2", "type": "umlsterm", "text": [ "tumor" ], "offsets": [ [ 860, 865 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.50160421.eng.abstr-s10-t3", "type": "umlsterm", "text": [ "cells" ], "offsets": [ [ 922, 927 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "DerPathologe.50160421.eng.abstr-s10-t4", "type": "umlsterm", "text": [ "mesenchyme" ], "offsets": [ [ 954, 964 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162415" } ] }, { "id": "DerPathologe.50160421.eng.abstr-s10-t5", "type": "umlsterm", "text": [ "sex-cord" ], "offsets": [ [ 1016, 1024 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0079399" }, { "db_name": "UMLS", "db_id": "C0009253" } ] }, { "id": "DerPathologe.50160421.eng.abstr-s10-t6", "type": "umlsterm", "text": [ "muscle" ], "offsets": [ [ 1051, 1057 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026845" } ] }, { "id": "DerPathologe.50160421.eng.abstr-s10-t7", "type": "umlsterm", "text": [ "cell" ], "offsets": [ [ 1084, 1088 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "DerPathologe.50160421.eng.abstr-s10-t8", "type": "umlsterm", "text": [ "clusters" ], "offsets": [ [ 1089, 1097 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009085" } ] }, { "id": "DerPathologe.50160421.eng.abstr-s10-t9", "type": "umlsterm", "text": [ "stromal cells" ], "offsets": [ [ 914, 927 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162597" } ] }, { "id": "DerPathologe.50160421.eng.abstr-s10-t10", "type": "umlsterm", "text": [ "smooth muscle" ], "offsets": [ [ 1044, 1057 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026843" } ] }, { "id": "DerPathologe.50160421.eng.abstr-s10-t11", "type": "umlsterm", "text": [ "stromal cell" ], "offsets": [ [ 1076, 1088 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162597" } ] } ]
[]
[]
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DerPathologe.50160426.eng.abstr
DerPathologe.50160426.eng.abstr
[ { "id": "DerPathologe.50160426.eng.abstr-passage-0", "type": "abstract", "text": [ "A 25-year-old patient with a rapidly growing sarcomatoid carcinoma of the urinary bladder is reported . The diagnosis was made on the basis of extended atypical proliferations of spindle or pleomorphic cells in the area of pelvic floor and the radix of the penis . The tumor showed invasion of the blood and a high Ki-67 growth fraction up to 40 % . Immunohistochemically , the reactions with antibodies against cytokeratin , EMA , and vimentin were positive , while negative results were obtained in reactions with antibodies against desmin , actin , PSA , S 100 , human epithelial antigen ( Ber-EP4), and cytokeratin 13. The differential diagnosis against myosarcomas , pseudosarcomatous lesions , and inflammatory pseudotumours is discussed . After radical surgery a pelvic recurrence and pulmonary metastases developed , which led to the patient's death 3 months later . This case shows that sarcomatoid carcinomas of the urinary bladder can be found even in young people ." ], "offsets": [ [ 0, 977 ] ] } ]
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[]
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DerPathologe.50160431.eng.abstr
DerPathologe.50160431.eng.abstr
[ { "id": "DerPathologe.50160431.eng.abstr-passage-0", "type": "abstract", "text": [ "Oncocytomas are rare epithelial tumors of the major and minor salivary glands . Reported is an oncocytoma of the lateral wall of the left nasal cavity in a 60-year-old man . Because of its locally invasive character , with rupture into the left nasal cavity and partial dedifferentiation with loss of typically oncocytic features , we classified the tumor as oncocytoma of low malignant potential ." ], "offsets": [ [ 0, 398 ] ] } ]
[ { "id": "DerPathologe.50160431.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Oncocytomas" ], "offsets": [ [ 0, 11 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0206670" } ] }, { "id": "DerPathologe.50160431.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "tumors" ], "offsets": [ [ 32, 38 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.50160431.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "minor" ], "offsets": [ [ 56, 61 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026193" } ] }, { "id": "DerPathologe.50160431.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "epithelial tumors" ], "offsets": [ [ 21, 38 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0205853" } ] }, { "id": "DerPathologe.50160431.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "salivary glands" ], "offsets": [ [ 62, 77 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036098" } ] }, { "id": "DerPathologe.50160431.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "minor salivary glands" ], "offsets": [ [ 56, 77 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036099" } ] }, { "id": "DerPathologe.50160431.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "oncocytoma" ], "offsets": [ [ 95, 105 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0206670" } ] }, { "id": "DerPathologe.50160431.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "man" ], "offsets": [ [ 168, 171 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025266" }, { "db_name": "UMLS", "db_id": "C0024554" } ] }, { "id": "DerPathologe.50160431.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "nasal cavity" ], "offsets": [ [ 138, 150 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027423" } ] }, { "id": "DerPathologe.50160431.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "character" ], "offsets": [ [ 206, 215 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007952" } ] }, { "id": "DerPathologe.50160431.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "rupture" ], "offsets": [ [ 223, 230 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035955" } ] }, { "id": "DerPathologe.50160431.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "tumor" ], "offsets": [ [ 350, 355 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.50160431.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "oncocytoma" ], "offsets": [ [ 359, 369 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0206670" } ] }, { "id": "DerPathologe.50160431.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "malignant" ], "offsets": [ [ 377, 386 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006826" } ] }, { "id": "DerPathologe.50160431.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "nasal cavity" ], "offsets": [ [ 245, 257 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027423" } ] } ]
[]
[]
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DerPathologe.60170001.eng.abstr
DerPathologe.60170001.eng.abstr
[ { "id": "DerPathologe.60170001.eng.abstr-passage-0", "type": "abstract", "text": [ "Problems in diagnosis of bone tumors in routine laboratories concern very rare tumors , differentiation between chondroma and low grade chondrosarcoma , the recognition of lesions containing multinucleated giant cells , lesions with secondary cysts simulating iuvenile or aneurysmal bone cyst and sometimes the discrimination of callus from osteosarcoma . Real misdiagnoses are done in ossifying pseudotumors interpreted as osteosarcoma , metaphyseal fibrous defect confound with giant cell tumor and chondroblastoma misdiagnosed as giant cell tumor or osteosarcoma . All these mistakes are avoidable if the clinical and radiological features , especially age and exact site in bone studied on the x-rays , are taken into consideration ." ], "offsets": [ [ 0, 737 ] ] } ]
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[]
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DerPathologe.60170006.eng.abstr
DerPathologe.60170006.eng.abstr
[ { "id": "DerPathologe.60170006.eng.abstr-passage-0", "type": "abstract", "text": [ "Ewing's sarcoma is a very rare tumor which has , however , attracted much oncological interest since the dramatic improvement of its prognosis under chemotherapy . Its histogenesis has been discussed controversially for a long time , including a possible origin in immature reticulum , myogenous , endothelial and undifferentiated mesenchymal cells . Repeated reports have also suggested a possible neuroectodermal genesis . Convincing arguments , however , have only been brought forward during recent years , since it was found that Ewing's sarcoma and malignant peripheral neuroectodermal tumor share a common chromosome translocation 11 ; 22. In the meantime this hypothesis has been strengthened by numerous cell biological analyses . There seems to be no clear border between Ewing's sarcoma and malignant peripheral neuroectodermal tumors with definite neural differentiation . Histological differential diagnosis of Ewing's sarcoma has been improved by immunohistological methods . In most cases , they can be distinguished from lymphoma ( leucocyte common antigen , B and T markers ) and embryonal rhabdomyosarcoma ( muscle specific actin , desmin ) without problems . Apart from that , it is possible nowadays to obtain antibodies against the MIC 2-protein , which is preferably expressed in Ewing sarcoma . The diagnostics of Ewing's sarcoma and the malignant peripheral neuroectodermal tumor have considerably been enriched by the fact that the specific chromosome translocation t ( 11 ; 22 ) can be proved molecular biologically . In contrast to the cytogenetic evidence , it is not necessary to establish cell cultures ." ], "offsets": [ [ 0, 1634 ] ] } ]
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[]
[]
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DerPathologe.60170018.eng.abstr
DerPathologe.60170018.eng.abstr
[ { "id": "DerPathologe.60170018.eng.abstr-passage-0", "type": "abstract", "text": [ "Chondrosarcomas are frequent malignant bone tumors . Aside from different subtypes , such as dedifferentiated , mesenchymal and clear-cell chondrosarcoma , chondrosarcomas ( classical chondrosarcoma ) show different grades of differentiation . The borderline between chondroma and classical chondrosarcoma is not clearly defined . The same chondrosarcoma can be graded differently at different institutes . Standardized therapy concepts are currently in preparation . As the Hamburg Bone Tumor Registry is often consulted for chondrogenic tumors , the histological criteria are based on a series of 74 chondrosarcomas recorded there . The emphasis has been laid on a classification which can be used in daily routine and which is reproducible and in agreement with the classifications of other international groups . Grade I chondrosarcomas ( 50 % ) can be distinguished only by growth criteria . The nuclei are small and show high chromatin density . Grade II chondrosarcomas ( 42 % ) have medium-sized , regular nuclei with loose chromatin structure . The chondrocytes of grade III cases ( 8 % ) show polymorphic nuclei . Binucleas forms , the number of mitoses and cellularity all show considerable overlap for all three grades . So far there are no immunohistological and molecular biological methods for reliable differentiation . The therapeutic consequences of the classification into grades are thorough curettage , in the case of grade I tumors , or complete resection , for grade II and III cases . The long-term results , however , need to be confirmed by a larger number of cases . From 1991 to 1995 the method was applied and proved to be easily practicable in daily diagnostic routine . Some 104 cases of classical chondrosarcomas ( grade I 53 % , grade II 39 % , grade III 8 % ) were analyzed . Two pathologists both assigned the same grade in 90 % of cases ." ], "offsets": [ [ 0, 1874 ] ] } ]
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[]
[]
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DerPathologe.60170035.eng.abstr
DerPathologe.60170035.eng.abstr
[ { "id": "DerPathologe.60170035.eng.abstr-passage-0", "type": "abstract", "text": [ "207 osteosarcomas were examined morphologically after neoadjuvant chemotherapy according to the COSS-86 protocol using representative slides of one whole tumor plane . The rate of responders 63 % . In relapse-free patients both the whole tumors and the vital areas there of were smaller than in patients with relapse during a follow-up period of 5 years . Within the subgroup of osteoblastic osteosarcomas , metastases were observed following smaller tumors than in chondroblastic osteosarcomas . Therefore , in addition to degree of regression , histological subtype and tumor size should be considered in the prognostic evaluation of osteosarcomas ." ], "offsets": [ [ 0, 651 ] ] } ]
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DerPathologe.60170044.eng.abstr
DerPathologe.60170044.eng.abstr
[ { "id": "DerPathologe.60170044.eng.abstr-passage-0", "type": "abstract", "text": [ "DNA cytometric investigations of intraosseous cystic lesions and osteoblastic tumors may be helpful in morphological diagnosis . The detection of a DNA-aneuploid stemline supports the diagnosis of a high-grade malignant bone neoplasm , even in small biopsies . Solitary and aneurysmal bone cysts have DNA-diploid cell populations . Low-grade central osteosarcomas may show single-cell aneuploidies of varying extent as well as a DNA-diploid stemline . Their presence may be a sign of genetic instability within the population of neoplastic cells before a DNA-aneuploid stemline is established and should prompt careful postoperative observation ." ], "offsets": [ [ 0, 646 ] ] } ]
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[]
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DerPathologe.60170050.eng.abstr
DerPathologe.60170050.eng.abstr
[ { "id": "DerPathologe.60170050.eng.abstr-passage-0", "type": "abstract", "text": [ "One of the mechanisms by which multidrug resistance is mediated , is the mdr1 gene product , P-glycooprotein . Immunohistochemistry was performed for 63 osteosarcomas of 54 patients to investigate P-glycoprotein expression using the monoclonal antibody JSB-1. Most of the patients were children or adolescents who had received treatment under the framework of the Cooperative Osteosarcoma Study Group . In addition P-glycoprotein expression was assayed in five growth plates . Of all cases 68.5 % stained positive for P-glycoprotein . Cases that had received chemotherapy showed a higher incidence ( 80.9 % ) of positive P-glycoprotein immunostaining than cases that had not received chemotherapy ( 66.6 % ) . No relation could be established between P-glycoprotein expression and the response to chemotherapy , since the majority of P-glycoprotein positive biopsies showed a good response in the surgical specimen after chemotherapy . Furthermore , 42.9 % of P-glycoprotein negative biopsies were classified as non-responders in the later surgical specimen ." ], "offsets": [ [ 0, 1059 ] ] } ]
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] }, { "id": "DerPathologe.60170050.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "chemotherapy" ], "offsets": [ [ 797, 809 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013216" }, { "db_name": "UMLS", "db_id": "C0013217" } ] }, { "id": "DerPathologe.60170050.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "biopsies" ], "offsets": [ [ 858, 866 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220797" }, { "db_name": "UMLS", "db_id": "C0005558" } ] }, { "id": "DerPathologe.60170050.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "surgical" ], "offsets": [ [ 897, 905 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "DerPathologe.60170050.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "chemotherapy" ], "offsets": [ [ 921, 933 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013216" }, { "db_name": "UMLS", "db_id": "C0013217" } ] }, { "id": "DerPathologe.60170050.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "biopsies" ], "offsets": [ [ 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[]
[]
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"DerPathologe.60170050.eng.abstr-s7-t2", "arg2_id": "DerPathologe.60170050.eng.abstr-s6-t3", "normalized": [] }, { "id": "DerPathologe.60170050.eng.abstr-s6-r2-t2.1-t1.1", "type": "precedes", "arg1_id": "DerPathologe.60170050.eng.abstr-s7-t2", "arg2_id": "DerPathologe.60170050.eng.abstr-s7-t1", "normalized": [] }, { "id": "DerPathologe.60170050.eng.abstr-s6-r3-t1.2-t3.1", "type": "precedes", "arg1_id": "DerPathologe.60170050.eng.abstr-s7-t1", "arg2_id": "DerPathologe.60170050.eng.abstr-s6-t3", "normalized": [] } ]
DerPathologe.60170056.eng.abstr
DerPathologe.60170056.eng.abstr
[ { "id": "DerPathologe.60170056.eng.abstr-passage-0", "type": "abstract", "text": [ "Bone tumors represent a group of tumors of various dignity . In spite of this single tumor entities may display strong morphological resemblance to each other which can in turn result in profound difficulties in differential diagnosis . The biological behaviour of a tumor is mainly determined by its rate of proliferation . In this study the rate of proliferation of 64 bone tumors ( 30 high-grade central osteosarcomas , 6 low-grade osteosarcomas , 8 giant cell tumors , 8 aneurysmatic bone cysts , 5 osteoidosteomas/osteoblastomas , 7 fibrous dysplasias and 5 cases of a myositis ossificans ) were analysed . Immunohistochemistry was performed on paraffin-embedded tissue sections using the MIB-1 monoclonal antibody . MIB-1 recognizes the proliferation-associated Ki-67 protein which is expressed during the active phases of the cell cycle but cannot be detected in senescent cells . Among high-grade central osteosarcomas a significantly higher rate of proliferation ( average value 30 % ) was found in comparison with low-grade osteosarcomas and other benign intraosseous bone tumors . This approach proved to be very useful in the distinction between high-grade and low-grade osteosarcomas as well as bone-forming intraosseous tumors . However distinguishing low-grade osteosarcomas from benign bone tumors by determining only the rate of proliferation was not possible , although interestingly , the proliferative rate of myositis ossificans , a purely reactive lesion , was in the range of the values determined for high-grade osteosarcoma ." ], "offsets": [ [ 0, 1550 ] ] } ]
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"offsets": [ [ 85, 90 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.60170056.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "morphological" ], "offsets": [ [ 119, 132 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0543482" } ] }, { "id": "DerPathologe.60170056.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "diagnosis" ], "offsets": [ [ 225, 234 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011900" }, { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerPathologe.60170056.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "differential diagnosis" ], "offsets": [ [ 212, 234 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220820" }, { "db_name": "UMLS", "db_id": "C0011906" } ] }, { "id": "DerPathologe.60170056.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "behaviour" ], "offsets": [ [ 252, 261 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004927" } ] }, { "id": "DerPathologe.60170056.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "tumor" ], "offsets": [ [ 267, 272 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.60170056.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "bone" ], "offsets": [ [ 371, 375 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0262950" } ] }, { "id": "DerPathologe.60170056.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "tumors" ], "offsets": [ [ 376, 382 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.60170056.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "osteosarcomas" ], "offsets": [ [ 407, 420 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029463" } ] }, { "id": "DerPathologe.60170056.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "osteosarcomas" ], "offsets": [ [ 435, 448 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029463" } ] }, { "id": "DerPathologe.60170056.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "giant" ], "offsets": [ [ 453, 458 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017547" } ] }, { "id": "DerPathologe.60170056.eng.abstr-s4-t6", "type": "umlsterm", "text": [ "cell" ], "offsets": [ [ 459, 463 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "DerPathologe.60170056.eng.abstr-s4-t7", "type": "umlsterm", "text": [ "tumors" ], "offsets": [ [ 464, 470 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.60170056.eng.abstr-s4-t8", "type": "umlsterm", "text": [ "bone" ], "offsets": [ [ 488, 492 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0262950" } ] }, { "id": "DerPathologe.60170056.eng.abstr-s4-t9", "type": "umlsterm", "text": [ "cysts" ], "offsets": [ [ 493, 498 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010709" } ] }, { "id": "DerPathologe.60170056.eng.abstr-s4-t10", "type": "umlsterm", "text": [ "myositis" ], "offsets": [ [ 574, 582 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027121" } ] }, { "id": "DerPathologe.60170056.eng.abstr-s4-t11", "type": "umlsterm", "text": [ "bone tumors" ], "offsets": [ [ 371, 382 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005967" } ] }, { "id": "DerPathologe.60170056.eng.abstr-s4-t12", "type": "umlsterm", "text": [ "giant cell" ], "offsets": [ [ 453, 463 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017526" } ] }, { "id": "DerPathologe.60170056.eng.abstr-s4-t13", "type": "umlsterm", "text": [ "bone cysts" ], "offsets": [ [ 488, 498 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005937" } ] }, { "id": "DerPathologe.60170056.eng.abstr-s4-t14", "type": "umlsterm", "text": [ "myositis ossificans" ], "offsets": [ [ 574, 593 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027122" } ] }, { "id": "DerPathologe.60170056.eng.abstr-s4-t15", "type": "umlsterm", "text": [ "giant cell tumors" ], "offsets": [ [ 453, 470 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017525" } ] }, { "id": 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DerPathologe.60170063.eng.abstr
DerPathologe.60170063.eng.abstr
[ { "id": "DerPathologe.60170063.eng.abstr-passage-0", "type": "abstract", "text": [ "Analysis of 402 solitary bone cysts demonstrates the wide morphological variation of this cystic lesion with regard to histology and radiology . Aside from metaphyseal location in femur ( 33 % ) and humerus ( 23 % ) , solitary bone cysts are also often located in calcaneus ( 11 % ) , tibia ( 11 % ) and pelvis ( 10 % ) . Most patients are in the second decade of life . Differentiation between this benign lesion and malignant bone tumors is very important in daily clinical routine . The diagnosis cannot be based solely on radiological findings because of the variation of solitary bone cysts and the special forms , such as calcifying solitary bone cyst . Therefore , exact histological diagnosis is of particular importance ." ], "offsets": [ [ 0, 730 ] ] } ]
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[]
[]
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DerPathologe.60170078.eng.abstr
DerPathologe.60170078.eng.abstr
[ { "id": "DerPathologe.60170078.eng.abstr-passage-0", "type": "abstract", "text": [ "Even today the name of F. D. von Recklinghausen is often mentioned in connection with primary and secondary hyperparathyroidism . He was one of the first physicians and scientists to render outstanding services to the classification of structural changes of bones , and in many aspects his work remains valid today . He succeeded through precise and comparative studies in making the disease and symptoms of primary hyperparathyroidism known and thus distinguishing it from other known structural bone diseases . He also described the phenomenon of \" bone remodeling \" which has become relevant today again . Although his written macroscopic and microscopic observations include meticulously precise differentiations which make it difficult to study them today , they are still of interest in order to follow his basic ideas . This article does not constitute a comprehensive biography , but it contains a description of F. D. von Recklinghausen's important work on bone pathology against the background of the main stages of his life ." ], "offsets": [ [ 0, 1036 ] ] } ]
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[]
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DerPathologe.60170083.eng.abstr
DerPathologe.60170083.eng.abstr
[ { "id": "DerPathologe.60170083.eng.abstr-passage-0", "type": "abstract", "text": [ "In this paper my experience with a databank for cases with bone diseases is reported . All cases which had been diagnosed in the newly formed Department of Bone Pathology of the University of Hamburg since 1970 were registered in uniform fashion . Adapting the system to state-of-the-art network structures required a lot of personal and financial investment . This could not be accomplished by university resources alone , but only in cooperation with other research funds . Now 76 000 cases can be routinely accessed and scientifically analysed ." ], "offsets": [ [ 0, 548 ] ] } ]
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[]
[]
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DerPathologe.60170086.eng.abstr
DerPathologe.60170086.eng.abstr
[ { "id": "DerPathologe.60170086.eng.abstr-passage-0", "type": "abstract", "text": [ "Periosteal osteosarcoma is a distinct bone tumor entity with characteristic morphological features within the group of juxtacortical osteosarcoma . Periosteal osteosarcoma is predominantly located in the long tubular bones , especially in the tibia and femur and is situated on the outer circumference of the tumor-bearing bone ( saucerization phenomenon ) . In contrast to parosteal osteosarcoma , periosteal osteosarcoma is less differentiated and is believed to have a worse prognosis . In this work the histological features are described with predominantly chondroblastic differentiation of 14 cases with periosteal osteosarcoma . A horizontal preparation technique of periosteal osteosarcoma specimens allows comparison with computed tomography and is the optimal method to detect an invasion of the medullary cavity . Further studies are necessary to clarify if neoadjuvant chemotherapy could improve the prognosis of certain patients ." ], "offsets": [ [ 0, 943 ] ] } ]
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[]
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DerPathologe.60170110.eng.abstr
DerPathologe.60170110.eng.abstr
[ { "id": "DerPathologe.60170110.eng.abstr-passage-0", "type": "abstract", "text": [ "Many cell types of the salivary glands have clear cytoplasm . Causes of clear cytoplasmic quality in light microscopy are loss of organelles , storage of substances or fixation artefacts . Differential diagnosis of the different clear cell types requires special staining techniques , immunocytochemistry and electron microscopy . A new and distinct salivary gland neoplasm is hyalinizing clear cell carcinoma , which was not included in the second edition of the WHO Classification of Salivery Gland Tumours . Analysis of the collected cases of the Salivary Gland Register Hamburg and recent reports in the literature reveal that this carcinoma shows low-grade malignancy with localization usually in the minor salivary glands . Most cases occur in women . The pathohistology is characterized by solid or trabecular formations of polygonal clear cells which are surrounded by a broad hyalinized desmoplastic connective tissue stroma . The clear cells are mucin negative and express cytokeratin and EMA , in some cases also CEA , but not S-100 protein , actin or other markers of myoepithelial cells . Ultrastructural findings are undifferentiated duct cells with only few organelles and inclusion of glycogen granules . The differential diagnosis includes other clear cell tumours , especially epithelial-myoepithelial carcinoma and the clear cell variants of myoepithelial carcinoma and acinic cell or mucoepidermoid carcinoma ." ], "offsets": [ [ 0, 1430 ] ] } ]
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DerPathologe.60170122.eng.abstr
DerPathologe.60170122.eng.abstr
[ { "id": "DerPathologe.60170122.eng.abstr-passage-0", "type": "abstract", "text": [ "Gastric carcinoma of the infiltrative type ( according to Ming ) occasionally shows adenomatous differentiation only . Over the past 18 years , we have observed 23 cases of this tumour type , accounting for 3.6 % of all surgically treated gastric carcinomas . Macroscopically they were classified as Borrmann IV or III , while histologically most of them were well differentiated . Histologically , these tumours retained the pre-existing structures of the stomach , most readily observable at the tunica muscularis propria ; a pronounced desmoplasia was also characteristic , particularly in the submucosal and subserosal layers . In all cases the tumour tissue spread inside lymphatic vessels . All but 2 cases with metastatically involved lymph nodes , often small , showed infiltration of the lymph node sinus ; in three quarters of cases the serosa was infiltrated by the tumour . Significant findings among the patients under observation for extended periods included bilateral ovarian metastases in 4 of 5 women examined and tumour recurrence at the anastomosis in 6 of 9 patients in whom Billroth II operation had been performed . The mean survival time of 16 patients was 14.9 months . Owing to the diffuse type of tumour growth , extensive surgery is recommended as in cases of signet ring cell cancer . The high incidence of small lymph node metastases from this type of tumour should also be taken in account at preoperative staging . Preoperative diagnosis of this tumour subtype is difficult , because histological criteria alone do not allow clear identification . Close cooperation with clinical investigators is necessary , and intraoperative assessment of the tumour - including frozen section of necessary - in particular is of the outmost importance ." ], "offsets": [ [ 0, 1771 ] ] } ]
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DerPathologe.60170127.eng.abstr
DerPathologe.60170127.eng.abstr
[ { "id": "DerPathologe.60170127.eng.abstr-passage-0", "type": "abstract", "text": [ "In the treatment of basal cell carcinoma , squamous cell carcinoma and a number of other tumors of the skin , the reccurrence rate is tenfold lower if they are treated with micrographic surgery in comparison with tumors , assessed by parallel histological sections . We demonstrated this in our investigations including over 5900 cases . The rate of local recurrences is under 1 % . The difference can be explained by the typical growth pattern of skin tumors . In the following article two simple methods of tissue processing are described , which can be used for formalin-fixed tissues and for fresh tissues ." ], "offsets": [ [ 0, 611 ] ] } ]
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[]
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DerPathologe.60170130.eng.abstr
DerPathologe.60170130.eng.abstr
[ { "id": "DerPathologe.60170130.eng.abstr-passage-0", "type": "abstract", "text": [ "\" NoToX Histological Fixative \" is a formaldehyde substitute for the fixation of tissues prior to histological investigation . Intraoperative samples and necropsy tissue were tested . NoToX was substituted for formaldehyde in the fixation step , otherwise the same manufacturer-specified protocols were used for all reagents . Conventional histological and accepted immunohistological investigations , especially for tumour diagnosis , were used . In all tests , results with NoToX-fixated tissue were similar to those with tissue fixed with formaldehyde regarding both staining and diagnosis . NoToX is a useful substitute for formaldehyde ." ], "offsets": [ [ 0, 642 ] ] } ]
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[]
[]
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DerPathologe.60170133.eng.abstr
DerPathologe.60170133.eng.abstr
[ { "id": "DerPathologe.60170133.eng.abstr-passage-0", "type": "abstract", "text": [ "This report presents the cases of two female patients aged 54 and 57 years , both with colon involvement of type 1 neurofibromatosis . The first woman had a polypoid neuronal hyperplasia containing small Wagner-Meissner corpuscles , which had allowed identification of the neuronal nature of the lesion in a small mucosal biopsy specimen taken previously . The second patient had an idiopathic megacolon of the sigmoid , which had to be extirpated because of acute obstruction and ileus . Morphological examination revealed a typical plexiform neurofibroma of the bowel wall and neuronal hyperplasia of the colonic mucosa and submucosa , which had obviously caused disordered gut mobility leading to functional stenosis and extreme dilatation of prestenotic bowel parts . Gastrointestinal neurofibromatosis is rare and is characterized morphologically by neuronal hyperplasia of the mucosa and submucosa , sometimes containing small aggregates of ganglion cells by which it can easily be identified . However , in the majority of cases the increase of proliferating mucosal nerve fibres can only be confirmed by S-100 protein immunostaining . Furthermore , solitary , multiple and plexiform neurofibromas are found , but only the last , which arises from mesenteric or subserosal nerves , is virtually pathognomonic for neurofibromatosis . Gastrointestinal neurofibromas are usually late manifestations of the disease , but in exceptional cases they can be the initial sign of neurofibromatosis in patients who have no external stigmata that arouse suspicion . The occurrence of gastrointestinal neurofibromas should therefore lead to a careful search for other features of NF-1 in the affected patients and in their families ." ], "offsets": [ [ 0, 1727 ] ] } ]
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"C0220797" }, { "db_name": "UMLS", "db_id": "C0005558" } ] }, { "id": "DerPathologe.60170133.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 368, 375 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerPathologe.60170133.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "megacolon" ], "offsets": [ [ 394, 403 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025160" } ] }, { "id": "DerPathologe.60170133.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "sigmoid" ], "offsets": [ [ 411, 418 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0227391" } ] }, { "id": "DerPathologe.60170133.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "ileus" ], "offsets": [ [ 481, 486 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021843" } ] }, { "id": "DerPathologe.60170133.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "Morphological" ], "offsets": [ [ 489, 502 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0543482" } ] }, { "id": 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[ "dilatation" ], "offsets": [ [ 732, 742 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012356" }, { "db_name": "UMLS", "db_id": "C0012359" } ] }, { "id": "DerPathologe.60170133.eng.abstr-s4-t8", "type": "umlsterm", "text": [ "bowel" ], "offsets": [ [ 758, 763 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021853" } ] }, { "id": "DerPathologe.60170133.eng.abstr-s4-t9", "type": "umlsterm", "text": [ "plexiform neurofibroma" ], "offsets": [ [ 534, 556 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0206728" } ] }, { "id": "DerPathologe.60170133.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "neurofibromatosis" ], "offsets": [ [ 789, 806 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162678" } ] }, { "id": "DerPathologe.60170133.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "hyperplasia" ], "offsets": [ [ 864, 875 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020507" } ] }, { "id": "DerPathologe.60170133.eng.abstr-s5-t3", "type": "umlsterm", "text": [ 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[]
[]
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"DerPathologe.60170133.eng.abstr-s9-t4", "normalized": [] }, { "id": "DerPathologe.60170133.eng.abstr-s9-r4-t4.1-t3.1", "type": "interacts_with", "arg1_id": "DerPathologe.60170133.eng.abstr-s9-t4", "arg2_id": "DerPathologe.60170133.eng.abstr-s9-t3", "normalized": [] } ]
DerPathologe.60170145.eng.abstr
DerPathologe.60170145.eng.abstr
[ { "id": "DerPathologe.60170145.eng.abstr-passage-0", "type": "abstract", "text": [ "We report on a female preterm infant of 29 weeks ' gestation with severe hydrops fetalis who died 3 days post natum as a result of disseminated intravascular coagulation . Autopsy findings included anasarca , bilateral pleural effusions , ascites and hepatosplenomegaly as well as multiple , up to pinhead sized , white granulomas on the surface of liver , spleen and lungs . Microscopy revealed storage macrophages of the reticuloendothelial system , especially in liver , spleen and bone marrow , the lymphatic organs , the salivary glands , the thyroid gland and the suprarenal medulla . Cerebrum , heart , kidneys , intestines and placenta were not afflicted . Atrophy of the lymphatic compartments in the spleen , lymph nodes and thymus , as well as disorder of the liver texture , are presumably a secondary result . The diagnosis of Farber's disease was established biochemically by the demonstration of ceramide depositions in the spleen , and in fibroblast cultures in situ by the accumulation of ceramide released from loaded radioactive glucosylceramide . Ultrastructurally , corresponding storage lysosomes were found in macrophages . To our knowledge this is the first account of Farber's disease in a preterm infant with hydrops fetalis ." ], "offsets": [ [ 0, 1252 ] ] } ]
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"type": "umlsterm", "text": [ "white" ], "offsets": [ [ 314, 319 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043157" } ] }, { "id": "DerPathologe.60170145.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "granulomas" ], "offsets": [ [ 320, 330 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018188" } ] }, { "id": "DerPathologe.60170145.eng.abstr-s2-t7", "type": "umlsterm", "text": [ "liver" ], "offsets": [ [ 349, 354 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0345904" }, { "db_name": "UMLS", "db_id": "C0023884" } ] }, { "id": "DerPathologe.60170145.eng.abstr-s2-t8", "type": "umlsterm", "text": [ "spleen" ], "offsets": [ [ 357, 363 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037993" }, { "db_name": "UMLS", "db_id": "C0153470" } ] }, { "id": "DerPathologe.60170145.eng.abstr-s2-t9", "type": "umlsterm", "text": [ "lungs" ], "offsets": [ [ 368, 373 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024109" } ] }, { "id": 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"db_id": "C0153470" } ] }, { "id": "DerPathologe.60170145.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "bone" ], "offsets": [ [ 485, 489 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0262950" } ] }, { "id": "DerPathologe.60170145.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "marrow" ], "offsets": [ [ 490, 496 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376152" } ] }, { "id": "DerPathologe.60170145.eng.abstr-s3-t7", "type": "umlsterm", "text": [ "thyroid" ], "offsets": [ [ 548, 555 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040132" }, { "db_name": "UMLS", "db_id": "C0040134" } ] }, { "id": "DerPathologe.60170145.eng.abstr-s3-t8", "type": "umlsterm", "text": [ "medulla" ], "offsets": [ [ 581, 588 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001629" }, { "db_name": "UMLS", "db_id": "C0025148" } ] }, { "id": "DerPathologe.60170145.eng.abstr-s3-t9", "type": "umlsterm", "text": [ "reticuloendothelial system" ], "offsets": [ [ 423, 449 ] ], 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"UMLS", "db_id": "C0001629" } ] }, { "id": "DerPathologe.60170145.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "Cerebrum" ], "offsets": [ [ 591, 599 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242202" } ] }, { "id": "DerPathologe.60170145.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "heart" ], "offsets": [ [ 602, 607 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018787" } ] }, { "id": "DerPathologe.60170145.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "kidneys" ], "offsets": [ [ 610, 617 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022646" } ] }, { "id": "DerPathologe.60170145.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "intestines" ], "offsets": [ [ 620, 630 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021853" } ] }, { "id": "DerPathologe.60170145.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "placenta" ], "offsets": [ [ 635, 643 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032043" } ] }, { "id": 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"UMLS", "db_id": "C0012634" } ] }, { "id": "DerPathologe.60170145.eng.abstr-s8-t3", "type": "umlsterm", "text": [ "infant" ], "offsets": [ [ 1223, 1229 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021270" } ] }, { "id": "DerPathologe.60170145.eng.abstr-s8-t4", "type": "umlsterm", "text": [ "hydrops" ], "offsets": [ [ 1235, 1242 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013604" } ] }, { "id": "DerPathologe.60170145.eng.abstr-s8-t5", "type": "umlsterm", "text": [ "hydrops fetalis" ], "offsets": [ [ 1235, 1250 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020305" } ] } ]
[]
[]
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DerPathologe.60170150.eng.abstr
DerPathologe.60170150.eng.abstr
[ { "id": "DerPathologe.60170150.eng.abstr-passage-0", "type": "abstract", "text": [ "The alveolar adenoma of the lung is a rare benign tumor in which the normal parenchymal architectur is imitated by a proliferation of both the alveolar epithelial cells and the mesenchymal septal cells . The first description , based on six cases , was published in 1986 by Yousem and Hochholzer . From their ultrastructural findings they presumed a type II pneumocytes differentiation of the epithelial cells . We investigated an alveolar adenoma of the lung immunhistochemical by means of antibodies against apoprotein B and C of human surfactant . Both the lining cells and the macrophages in the alveolar-like spaces were stained . The septal connection tissue cells did not react . These findings confirm the expression of surfactant constituants and , hence , the differentiation into type II pneumocytes of the epithelial cells of the alveolar adenoma ." ], "offsets": [ [ 0, 860 ] ] } ]
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[]
[]
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DerPathologe.60170154.eng.abstr
DerPathologe.60170154.eng.abstr
[ { "id": "DerPathologe.60170154.eng.abstr-passage-0", "type": "abstract", "text": [ "A 28-year-old drug addict who had injected intravenously died of hepatic failure and coma caused by fulminant hepatitis ( simultaneously : hepatitis A , persistent hepatitis B , hepatitis C and superinfection by delta hepatitis ) . Liver histology disclosed cirrhosis with severe necrotizing hepatitis and extensive microvesicular steatosis , compatible with a delta virus infection . Moderate pulmonary fat embolism ( grade I-II according to Falzi ) was accompanied by fat deposits in alveolar macrophages . It is postulated that protracted fat mobilization from necrotizing hepatocytes may be the cause of pulmonary fat embolism ; the extravasation of fat from the vessels into the alveoli results in phagocytosis by alveolar macrophages ." ], "offsets": [ [ 0, 741 ] ] } ]
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[]
[]
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DerPathologe.60170157.eng.abstr
DerPathologe.60170157.eng.abstr
[ { "id": "DerPathologe.60170157.eng.abstr-passage-0", "type": "abstract", "text": [ "Sclerosing adenosis of the prostate is a benign lesion , which was not recognized until a few years ago . As in sclerosing adenosis of the breast , a background of various hyperplastic changes is commonly also present in the prostate . An incidence of 2.8 % was reported in one series of resected hyperplastic prostatic glands . As demonstrated in this case report , the main problem lies in the differential diagnosis between sclerosing adenosis and highly differentiated adenocarcinoma of the prostate . Histological diagnosis of sclerosing adenosis based on routine HE sections is supplemented by immunohistochemical methods . Important diagnostic criteria of sclerosing adenosis are the presence of basal cell differentiation , which is demonstrated by cytokeratin 903 , and signs of possible myoepithelial differentiation , with expression of S-100 and/or smooth muscle actin . These antibody expressions are lacking with in the presence of adenocarcinoma of the prostate . Nevertheless , in a small number of cases this differential diagnosis remains impossible , even after the application of immunohistochemical methods . Further studies are needed to shed some light on the relations between sclerosing adenosis , atypical adenomatous hyperplasia and adenocarcinoma of the prostate . So far , there appears to be no evidence of a direct relationship between sclerosing adenosis of the prostate and an elevated risk of carcinoma ." ], "offsets": [ [ 0, 1438 ] ] } ]
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[]
[]
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DerPathologe.60170163.eng.abstr
DerPathologe.60170163.eng.abstr
[ { "id": "DerPathologe.60170163.eng.abstr-passage-0", "type": "abstract", "text": [ "Bronchiolo-alveolar tumorlets - mostly clinically asymptomatic - generally are noticed as \" contingent findings \" in the diagnoses of interstitial fibrosing lung diseases . The growth fraction of these epithelial proliferates in the WHO classification sumarized in the group of tumor like lesions was explored by immunohistochemical stainings with the PCNA and Ki67 ( MIB1) antibodies and correlated with ( pre- ) neoplastic lesions of the lung . The proliferation indices varied between 0.029 to 0.67 ( MIB1) and 0.057 to 0.81 ( PCNA ) . Depending on the main disease the observation of cuboid metaplasias , areas of bronchiolization via tumorlets in inactive interstitial lung fibrosis up to bronchiolo alveolar tumorlets following interstitial lung disease after cytostatical treatment showed increasing proliferation indices . Accordingly to prencoplastic changes of the bronchial epithelium the findings suggest that interpretation of bronchiolo alveolar tumorlets as basic cells of malignant peripheral lung tumors seems to be possible . The value of these findings in relationship to the associated interstitial lung disease is discussed in the context of reflections related to the formal pathogenesis of so called scar cancer ." ], "offsets": [ [ 0, 1236 ] ] } ]
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[]
[]
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DerPathologe.60170189.eng.abstr
DerPathologe.60170189.eng.abstr
[ { "id": "DerPathologe.60170189.eng.abstr-passage-0", "type": "abstract", "text": [ "Comparative genomic hybridisation ( CGH ) is a new cytogenetic method , which is based on a combination of fluorescence microscopy and digital image analysis . The molecular genetic basis is the hybridization of a mixture of fluorescein labeled test-DNA and reference-DNA on normal metaphase chromosomes . Comparative analysis allows the identification of all unbalanced chromosomal aberrations of the test-DNA in a single experimental step . The resulting DNA gains or DNA losses on the chromosomal or subchromosomal level mirror possible amplifications of oncogenes or losses of suppress orgenes . As CGH can be performed with genomic DNA of formalin-fixed and fresh-frozen tissue or cells , this new method is a very effective tool for pathologists and cytologists in the extended genomic screening of tumors and genetically altered tissues . Despite CGH analysis at present is restricted to research applications ; its widespread dissemination as a routine method in diagnostic pathology can be expected in the near future ." ], "offsets": [ [ 0, 1028 ] ] } ]
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DerPathologe.60170195.eng.abstr
DerPathologe.60170195.eng.abstr
[ { "id": "DerPathologe.60170195.eng.abstr-passage-0", "type": "abstract", "text": [ "CD34 is a myeloid progenitor cel antigen and present in endothelial cells and almost all vascular lesions . Additionally , CD34 has been described in numerous fibroblast-like cells and different mesenchymal tumours . The immunohistochemical evidence of CD34, however , may be of importance in the differential diagnosis of benign and malignant soft tissue lesions , if clinicopathological features and other immunohistochemical markers are regarded properly . We studied the CD34 immunopositivity of solitary fibrous tumour at different sites ( 11 out of 11 tumours tested stained positive ) , dermatofibrosarcoma protuberans ( 15 out of 18 stained positive ) , and gastrointestinal stromal tumour ( 15 out of 15 stained positive ) , and discuss the significance of these results in differential diagnosis to morphologically comparable soft tissue lesions ." ], "offsets": [ [ 0, 857 ] ] } ]
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[]
[]
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DerPathologe.60170202.eng.abstr
DerPathologe.60170202.eng.abstr
[ { "id": "DerPathologe.60170202.eng.abstr-passage-0", "type": "abstract", "text": [ "The influence of oral contraceptives ( OC ) on histomorphological and molecular biological prognostic factors was studied in 471 breast cancer patients . Differences in histological tumor type , histological grade , tumor size , lymph node status , hormonal receptor status , PCNA expression and c-erbB-2 protein overexpression were investigated in relation to the duration of OC use ( 5 years/ > = 5 years ) and the time since last use . A total of 297 ( 63 % ) patients had used oral contraceptives at some time in their life ; 186 patients ( 39.5 % ) had used OC's for 5 years or more . There were no significant differences in the tumor characteristics investigated with respect to OC use in general . Neither long-term use at some time in their life nor long-term use until breast cancer diagnosis had an effect on histomorphological and molecular biological factors . Thus , steroid hormones contained in OC's had no direct effect on prognostic factors in breast cancer ." ], "offsets": [ [ 0, 977 ] ] } ]
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[]
[]
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DerPathologe.60170213.eng.abstr
DerPathologe.60170213.eng.abstr
[ { "id": "DerPathologe.60170213.eng.abstr-passage-0", "type": "abstract", "text": [ "We report a sporadic case of giant axonal neuropathy ( GAN ) starting in a 5-year-old boy with gait disturbance . At the age of 10 years he showed signs of a sensomotoric polyneuropathy and central neurological symptoms : intention tremor , nystagmus and visual disturbance . The boy also had curly hair . Sural nerve biopsy showed many giant axons with accumulation of microfilaments , which were also found in cytoplasma of Schwann cells , endothelial cells and fibrocytes . Similar changes were detected in endothelial cells of a muscle biopsy , which additionally displayed neurogenic atrophy and target fibers . Immunohistochemically , desmin , vimentin , heat shock protein 70 , and ubiquitin were not detectable in giant axons , which , however , contained neurofilament protein 68 , 200 and -tubulin . Our case shows that careful ultrastructural examination of a muscle biopsy may point to the diagnosis of GAN ." ], "offsets": [ [ 0, 920 ] ] } ]
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DerPathologe.60170219.eng.abstr
DerPathologe.60170219.eng.abstr
[ { "id": "DerPathologe.60170219.eng.abstr-passage-0", "type": "abstract", "text": [ "Benign giant cell bone tumors sometimes develop benign pulmonary metastases . Most of these appear 3 to 4 years after the treatment of the primary tumor . Metastases have been diagnosed up to 11 years after the first diagnosis . The following is a case report of a 58-year-old man who developed lung metastases 27 years after the treatment of an aggressive local recurrence ." ], "offsets": [ [ 0, 375 ] ] } ]
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[]
[]
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DerPathologe.60170222.eng.abstr
DerPathologe.60170222.eng.abstr
[ { "id": "DerPathologe.60170222.eng.abstr-passage-0", "type": "abstract", "text": [ "The case is presented of a 51-year-old woman with increased of nightly dyspnea . An echocardiographic examination shows two intracardiac tumors . Histological features demonstrate an malignant schwannoma . The diagnosis was verified by immunohistological proof of S-100 protein in tumor cells ." ], "offsets": [ [ 0, 294 ] ] } ]
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[]
[]
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DerPathologe.60170227.eng.abstr
DerPathologe.60170227.eng.abstr
[ { "id": "DerPathologe.60170227.eng.abstr-passage-0", "type": "abstract", "text": [ "The incidence of the prostatic carcinoma as well as the cases treatable by radical prostatovesiculectomy with curative intention is increasing . The exact pathological examination of the specimens defines the stage of disease and subsequently the prognosis and therapeutic consequences . The compatibility of different scientifical studies is made difficult by the lack of a standard in the pathological examination of the specimens . Our exactly defined rational method helps eliminate these troubles and ameliorate the interdisciplinary dialogue ." ], "offsets": [ [ 0, 549 ] ] } ]
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[]
[]
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DerPathologe.60170231.eng.abstr
DerPathologe.60170231.eng.abstr
[ { "id": "DerPathologe.60170231.eng.abstr-passage-0", "type": "abstract", "text": [ "A 74-year-old man suffered from symptoms of a left upper lobe pneumonia . Additional retrosternal masses were proved . Progression in the left upper lobe occurred in spite of antibiotic therapy ; infiltrations of the right lower lobe were seen . No germs could be identified . Bronchoscopy and mediastinoscopy showed no pathological findings . His general health became worse , and the patient died under the clinical diagnosis of \" wandering pneumonia \" with finally suspicion of fulminant pulmonary artery embolism . Autopsy findings revealed an advanced stage of pulmonary artery sarcoma with myocardial infiltration and metastases in both kidneys and thyroid gland . General manifestation of pulmonary artery sarcoma usually are symptoms similar to those caused by pulmonary artery embolism with obstruction of pulmonary arterial flow . The unusual constellation of clinical findings similar to colliquating pneumonia results in secondary infection due to tumorous pulmonary infarction . The difficulties in diagnosis by biopsy are caused by primary intravascular growth of the neoplasms . Therefore early diagnosis in an operable tumor stage by means of CT , MR , and angiography is very important ." ], "offsets": [ [ 0, 1204 ] ] } ]
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DerPathologe.60170254.eng.abstr
DerPathologe.60170254.eng.abstr
[ { "id": "DerPathologe.60170254.eng.abstr-passage-0", "type": "abstract", "text": [ "Cell-cell and cell-matrix adhesion molecules as well as extracellular matrix components are target structures of antibody-mediated autoimmunity that have recently been well characterized at the molecular biological level . Pathogenic autoantibodies against these molecules are causally related to disturbances of cell and tissue adhesion that become apparent as various ( muco- ) cutaneous blistering diseases . Desmosomal cadherins ( desmogleins and desmocollins ) mediate epidermal intercellular adhesion . Among these , desmoglein 1 and desmoglein 3 are the autoantigens of pemphigus foliaceus and pemphigus vulgaris , respectively , exhibiting intraepidermal blistering . The pathogenic relevance of autoantibodies against desmocollins ( IgA pemphigus ) and desmoplakins ( paraneoplastic pemphigus ) still remains unclear . Hemidesmosomes contain the plaque protein BPAG1 and the partly collagen-like transmembrane protein BPAG2, representing the autoantigens of bullous pemphigoid and pemphigoid gestationis with subepidermal blistering . A certain subtype of cicatricial ( benign mucous membrane ) pemphigoid is characterized by autoantibodies against laminin 5 present in the subhemidesmosomal anchoring filaments , while epidermolysis bullosa acquisita and bullous SLE exhibit autoantibodies against collagen type VII constituting the anchoring fibrils . In addition , autoantibodies against a particular collagen type IV chain of the glomerular basement membrane are responsible for the manifestation of Goodpasture's syndrome . These recent molecular biological findings might be the basis for the development of novel therapeutic strategies ." ], "offsets": [ [ 0, 1653 ] ] } ]
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[]
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"affects", "arg1_id": "DerPathologe.60170254.eng.abstr-s9-t3", "arg2_id": "DerPathologe.60170254.eng.abstr-s9-t1", "normalized": [] }, { "id": "DerPathologe.60170254.eng.abstr-s9-r3-t1.1-t2.1", "type": "result_of", "arg1_id": "DerPathologe.60170254.eng.abstr-s9-t1", "arg2_id": "DerPathologe.60170254.eng.abstr-s9-t2", "normalized": [] }, { "id": "DerPathologe.60170254.eng.abstr-s9-r4-t1.1-t2.1", "type": "evaluation_of", "arg1_id": "DerPathologe.60170254.eng.abstr-s9-t1", "arg2_id": "DerPathologe.60170254.eng.abstr-s9-t2", "normalized": [] }, { "id": "DerPathologe.60170254.eng.abstr-s9-r5-t2.1-t1.1", "type": "result_of", "arg1_id": "DerPathologe.60170254.eng.abstr-s9-t2", "arg2_id": "DerPathologe.60170254.eng.abstr-s9-t1", "normalized": [] } ]
DerPathologe.60170269.eng.abstr
DerPathologe.60170269.eng.abstr
[ { "id": "DerPathologe.60170269.eng.abstr-passage-0", "type": "abstract", "text": [ "Type I and type II diabetes are the most common types of diabetes . The ratio of type I to type II diabetes is about 1:9 . Type I diabetes is caused by an absolute insulin deficiency and is therefore referred to as insulin-dependent diabetes . The disease becomes manifest clinically in childhood or adolescence ( \" juvenile diabetes \" ) , although manifestation in adulthood is being increasingly observed . Morphologically , a subtotal ( > 80 % ) to total loss of beta cells in the pancreatic islets occurs . Lymphocytic insulitis , which disappears after the beta cells have been totally destroyed , is pathognomonic of type I diabetes . This insulitis is an expression of an autoimmune event that is triggered by a multitude of factors . An important factor appears to be a genetic predisposition ( HLA DR3/DR4/DQ8) in connection with as yet unknown environmental factors ( e . g . , viruses ) . Autoantibodies , such as islet cell cytoplasmic antibodies ( ICA ) , insulin autoantibodies ( IAA ) , and/or autoantibodies to the GABA-synthesizing enzyme glutamic acid carboxylase ( GAD ) , are already detectable in a prediabetic phase , although it is not possible to predict the time of clinical manifestion . The course of the disease is dependent on age . Young children require insulin therapy sooner than juveniles or adults ." ], "offsets": [ [ 0, 1334 ] ] } ]
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[]
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"DerPathologe.60170269.eng.abstr-s11-r61-t2.1-t5.1", "type": "produces", "arg1_id": "DerPathologe.60170269.eng.abstr-s13-t2", "arg2_id": "DerPathologe.60170269.eng.abstr-s11-t5", "normalized": [] }, { "id": "DerPathologe.60170269.eng.abstr-s11-r62-t4.1-t1.1", "type": "interacts_with", "arg1_id": "DerPathologe.60170269.eng.abstr-s13-t4", "arg2_id": "DerPathologe.60170269.eng.abstr-s13-t1", "normalized": [] }, { "id": "DerPathologe.60170269.eng.abstr-s11-r63-t10.1-t5.1", "type": "interacts_with", "arg1_id": "DerPathologe.60170269.eng.abstr-s11-t10", "arg2_id": "DerPathologe.60170269.eng.abstr-s11-t5", "normalized": [] }, { "id": "DerPathologe.60170269.eng.abstr-s11-r64-t7.2-t1.1", "type": "interacts_with", "arg1_id": "DerPathologe.60170269.eng.abstr-s11-t7", "arg2_id": "DerPathologe.60170269.eng.abstr-s13-t1", "normalized": [] }, { "id": "DerPathologe.60170269.eng.abstr-s11-r66-t7.1-t2.1", "type": "disrupts", "arg1_id": "DerPathologe.60170269.eng.abstr-s11-t7", "arg2_id": "DerPathologe.60170269.eng.abstr-s13-t2", "normalized": [] }, { "id": "DerPathologe.60170269.eng.abstr-s11-r67-t11.1-t5.1", "type": "produces", "arg1_id": "DerPathologe.60170269.eng.abstr-s11-t11", "arg2_id": "DerPathologe.60170269.eng.abstr-s11-t5", "normalized": [] }, { "id": "DerPathologe.60170269.eng.abstr-s12-r1-t2.2-t2.1", "type": "produces", "arg1_id": "DerPathologe.60170269.eng.abstr-s12-t2", "arg2_id": "DerPathologe.60170269.eng.abstr-s13-t2", "normalized": [] }, { "id": "DerPathologe.60170269.eng.abstr-s12-r2-t1.1-t2.2", "type": "result_of", "arg1_id": "DerPathologe.60170269.eng.abstr-s13-t1", "arg2_id": "DerPathologe.60170269.eng.abstr-s12-t2", "normalized": [] }, { "id": "DerPathologe.60170269.eng.abstr-s12-r3-t1.1-t2.1", "type": "occurs_in", "arg1_id": "DerPathologe.60170269.eng.abstr-s13-t1", "arg2_id": "DerPathologe.60170269.eng.abstr-s13-t2", "normalized": [] }, { "id": "DerPathologe.60170269.eng.abstr-s12-r4-t2.2-t1.1", "type": "result_of", "arg1_id": "DerPathologe.60170269.eng.abstr-s12-t2", "arg2_id": "DerPathologe.60170269.eng.abstr-s13-t1", "normalized": [] }, { "id": "DerPathologe.60170269.eng.abstr-s13-r1-t3.1-t2.1", "type": "uses", "arg1_id": "DerPathologe.60170269.eng.abstr-s13-t3", "arg2_id": "DerPathologe.60170269.eng.abstr-s13-t2", "normalized": [] }, { "id": "DerPathologe.60170269.eng.abstr-s13-r2-t1.1-t3.1", "type": "performs", "arg1_id": "DerPathologe.60170269.eng.abstr-s13-t1", "arg2_id": "DerPathologe.60170269.eng.abstr-s13-t3", "normalized": [] } ]
DerPathologe.60170276.eng.abstr
DerPathologe.60170276.eng.abstr
[ { "id": "DerPathologe.60170276.eng.abstr-passage-0", "type": "abstract", "text": [ "The aetiopathogenesis of auto-immune thyroid disease is still a matter for discussion . Morphologically , these illnesses are associated with a broad spectrum of overlapping changes . Thus , pathology cannot serve as the logical basis for a new classification . Therefore this overview makes use of the conventional nomenclature of clinically established entities and includes recently defined lesions . Besides histological characteristics , details of differential diagnostic value are presented in the context of clinical and laboratory data relevant for pathological classification ." ], "offsets": [ [ 0, 587 ] ] } ]
[ { "id": "DerPathologe.60170276.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "thyroid" ], "offsets": [ [ 37, 44 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040132" }, { "db_name": "UMLS", "db_id": "C0040134" } ] }, { "id": "DerPathologe.60170276.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 45, 52 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerPathologe.60170276.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "thyroid disease" ], "offsets": [ [ 37, 52 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040128" } ] }, { "id": "DerPathologe.60170276.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "pathology" ], "offsets": [ [ 191, 200 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0205469" }, { "db_name": "UMLS", "db_id": "C0030664" } ] }, { "id": "DerPathologe.60170276.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "classification" ], "offsets": [ [ 245, 259 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008902" }, { "db_name": "UMLS", "db_id": "C0008903" } ] }, { "id": "DerPathologe.60170276.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "use" ], "offsets": [ [ 292, 295 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042153" } ] }, { "id": "DerPathologe.60170276.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "nomenclature" ], "offsets": [ [ 316, 328 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0600281" } ] }, { "id": "DerPathologe.60170276.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "diagnostic" ], "offsets": [ [ 467, 477 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerPathologe.60170276.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "value" ], "offsets": [ [ 478, 483 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042295" } ] }, { "id": "DerPathologe.60170276.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "laboratory" ], "offsets": [ [ 529, 539 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022877" } ] }, { "id": "DerPathologe.60170276.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "classification" ], "offsets": [ [ 571, 585 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008902" }, { "db_name": "UMLS", "db_id": "C0008903" } ] } ]
[]
[]
[ { "id": "DerPathologe.60170276.eng.abstr-s1-r1-t1.2-t2.1", "type": "affects", "arg1_id": "DerPathologe.60170276.eng.abstr-s3-t1", "arg2_id": "DerPathologe.60170276.eng.abstr-s5-t2", "normalized": [] }, { "id": "DerPathologe.60170276.eng.abstr-s1-r2-t1.1-t1.2", "type": "produces", "arg1_id": "DerPathologe.60170276.eng.abstr-s5-t1", "arg2_id": "DerPathologe.60170276.eng.abstr-s3-t1", "normalized": [] }, { "id": "DerPathologe.60170276.eng.abstr-s1-r3-t1.1-t3.1", "type": "location_of", "arg1_id": "DerPathologe.60170276.eng.abstr-s5-t1", "arg2_id": "DerPathologe.60170276.eng.abstr-s5-t3", "normalized": [] }, { "id": "DerPathologe.60170276.eng.abstr-s1-r4-t1.2-t2.1", "type": "diagnoses", "arg1_id": "DerPathologe.60170276.eng.abstr-s3-t1", "arg2_id": "DerPathologe.60170276.eng.abstr-s5-t2", "normalized": [] }, { "id": "DerPathologe.60170276.eng.abstr-s1-r5-t2.1-t1.2", "type": "produces", "arg1_id": "DerPathologe.60170276.eng.abstr-s5-t2", "arg2_id": "DerPathologe.60170276.eng.abstr-s3-t1", "normalized": [] }, { "id": "DerPathologe.60170276.eng.abstr-s1-r6-t1.2-t3.1", "type": "affects", "arg1_id": "DerPathologe.60170276.eng.abstr-s3-t1", "arg2_id": "DerPathologe.60170276.eng.abstr-s5-t3", "normalized": [] }, { "id": "DerPathologe.60170276.eng.abstr-s1-r7-t1.1-t2.1", "type": "location_of", "arg1_id": "DerPathologe.60170276.eng.abstr-s5-t1", "arg2_id": "DerPathologe.60170276.eng.abstr-s5-t2", "normalized": [] }, { "id": "DerPathologe.60170276.eng.abstr-s1-r8-t3.1-t1.2", "type": "produces", "arg1_id": "DerPathologe.60170276.eng.abstr-s5-t3", "arg2_id": "DerPathologe.60170276.eng.abstr-s3-t1", "normalized": [] }, { "id": "DerPathologe.60170276.eng.abstr-s1-r9-t1.2-t3.1", "type": "diagnoses", "arg1_id": "DerPathologe.60170276.eng.abstr-s3-t1", "arg2_id": "DerPathologe.60170276.eng.abstr-s5-t3", "normalized": [] }, { "id": "DerPathologe.60170276.eng.abstr-s1-r10-t1.2-t1.1", "type": "disrupts", "arg1_id": "DerPathologe.60170276.eng.abstr-s3-t1", "arg2_id": "DerPathologe.60170276.eng.abstr-s5-t1", "normalized": [] }, { "id": "DerPathologe.60170276.eng.abstr-s3-r1-t2.2-t1.1", "type": "issue_in", "arg1_id": "DerPathologe.60170276.eng.abstr-s3-t2", "arg2_id": "DerPathologe.60170276.eng.abstr-s5-t1", "normalized": [] }, { "id": "DerPathologe.60170276.eng.abstr-s3-r2-t2.1-t1.1", "type": "issue_in", "arg1_id": "DerPathologe.60170276.eng.abstr-s5-t2", "arg2_id": "DerPathologe.60170276.eng.abstr-s5-t1", "normalized": [] }, { "id": "DerPathologe.60170276.eng.abstr-s5-r1-t1.1-t4.1", "type": "produces", "arg1_id": "DerPathologe.60170276.eng.abstr-s5-t1", "arg2_id": "DerPathologe.60170276.eng.abstr-s5-t4", "normalized": [] }, { "id": "DerPathologe.60170276.eng.abstr-s5-r2-t1.1-t4.2", "type": "produces", "arg1_id": "DerPathologe.60170276.eng.abstr-s5-t1", "arg2_id": "DerPathologe.60170276.eng.abstr-s5-t4", "normalized": [] } ]
DerPathologe.60170296.eng.abstr
DerPathologe.60170296.eng.abstr
[ { "id": "DerPathologe.60170296.eng.abstr-passage-0", "type": "abstract", "text": [ "We report a case of an intrathoracic , extrapleural , infantile rhabdomyofibrosarcoma in a 4-year-old boy . Histologically , the primary lesion showed extensive hyalinization and stroma sclerosis and was composed of relatively uniform spindle-shaped , at least focally rather polygonal tumour cells with scattered intracytoplasmatic globoid inclusions . Although chemo- and radiotherapy was given postoperatively , local recurrences and metastases in the lung and thymus have developed ; the patient died of tumour disease 3 years later . Recurrences and metastases showed features of tumour progression with higher cellularity and increased mitotic activity . Immunohistochemically , the tumour cells stained strongly positive for vimentin , desmin , and muscle-specific actin , and at least focally for MyoD1; the tumour did not stain for alpha-smooth muscle actin , neural and epithelial markers , or CD34 and CD31. The differential diagnosis of these aggressive tumours in the spectrum of spindle-cell lesions in early childhood is discussed ." ], "offsets": [ [ 0, 1047 ] ] } ]
[ { "id": "DerPathologe.60170296.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "extrapleural" ], "offsets": [ [ 39, 51 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032226" } ] }, { "id": "DerPathologe.60170296.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "sclerosis" ], "offsets": [ [ 186, 195 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036429" } ] }, { "id": "DerPathologe.60170296.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "tumour" ], "offsets": [ [ 286, 292 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.60170296.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "cells" ], "offsets": [ [ 293, 298 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "DerPathologe.60170296.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "radiotherapy" ], "offsets": [ [ 374, 386 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034618" }, { "db_name": "UMLS", "db_id": "C0034619" } ] }, { "id": "DerPathologe.60170296.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "recurrences" ], "offsets": [ [ 421, 432 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034897" } ] }, { "id": "DerPathologe.60170296.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "metastases" ], "offsets": [ [ 437, 447 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027627" } ] }, { "id": "DerPathologe.60170296.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "lung" ], "offsets": [ [ 455, 459 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024109" } ] }, { "id": "DerPathologe.60170296.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "thymus" ], "offsets": [ [ 464, 470 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040113" } ] }, { "id": "DerPathologe.60170296.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 492, 499 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerPathologe.60170296.eng.abstr-s3-t7", "type": "umlsterm", "text": [ "tumour" ], "offsets": [ [ 508, 514 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.60170296.eng.abstr-s3-t8", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 515, 522 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerPathologe.60170296.eng.abstr-s3-t9", "type": "umlsterm", "text": [ "patient died" ], "offsets": [ [ 492, 504 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011065" } ] }, { "id": "DerPathologe.60170296.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "Recurrences" ], "offsets": [ [ 539, 550 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034897" } ] }, { "id": "DerPathologe.60170296.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "metastases" ], "offsets": [ [ 555, 565 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027627" } ] }, { "id": "DerPathologe.60170296.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "tumour" ], "offsets": [ [ 585, 591 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.60170296.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "tumour" ], "offsets": [ [ 689, 695 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.60170296.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "cells" ], "offsets": [ [ 696, 701 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "DerPathologe.60170296.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "vimentin" ], "offsets": [ [ 732, 740 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042666" } ] }, { "id": "DerPathologe.60170296.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "desmin" ], "offsets": [ [ 743, 749 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011696" } ] }, { "id": "DerPathologe.60170296.eng.abstr-s5-t5", "type": "umlsterm", "text": [ "muscle-specific" ], "offsets": [ [ 756, 771 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026845" } ] }, { "id": "DerPathologe.60170296.eng.abstr-s5-t6", "type": "umlsterm", "text": [ "actin" ], "offsets": [ [ 772, 777 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001271" } ] }, { "id": "DerPathologe.60170296.eng.abstr-s5-t7", "type": "umlsterm", "text": [ "tumour" ], "offsets": [ [ 816, 822 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.60170296.eng.abstr-s5-t8", "type": "umlsterm", "text": [ "muscle" ], "offsets": [ [ 854, 860 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026845" } ] }, { "id": "DerPathologe.60170296.eng.abstr-s5-t9", "type": "umlsterm", "text": [ "actin" ], "offsets": [ [ 861, 866 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001271" } ] }, { "id": "DerPathologe.60170296.eng.abstr-s5-t10", "type": "umlsterm", "text": [ "markers" ], "offsets": [ [ 891, 898 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005516" } ] }, { "id": "DerPathologe.60170296.eng.abstr-s5-t11", "type": "umlsterm", "text": [ "CD34" ], "offsets": [ [ 904, 908 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0054953" } ] }, { "id": "DerPathologe.60170296.eng.abstr-s5-t12", "type": "umlsterm", "text": [ "diagnosis" ], "offsets": [ [ 936, 945 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011900" }, { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerPathologe.60170296.eng.abstr-s5-t13", "type": "umlsterm", "text": [ "tumours" ], "offsets": [ [ 966, 973 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.60170296.eng.abstr-s5-t14", "type": "umlsterm", "text": [ "spindle-cell" ], "offsets": [ [ 993, 1005 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "DerPathologe.60170296.eng.abstr-s5-t15", "type": "umlsterm", "text": [ "differential diagnosis" ], "offsets": [ [ 923, 945 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220820" }, { "db_name": "UMLS", "db_id": "C0011906" } ] } ]
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"DerPathologe.60170296.eng.abstr-s5-r102-t12.2-t9.1", "type": "produces", "arg1_id": "DerPathologe.60170296.eng.abstr-s5-t12", "arg2_id": "DerPathologe.60170296.eng.abstr-s5-t9", "normalized": [] } ]
DerPathologe.60170301.eng.abstr
DerPathologe.60170301.eng.abstr
[ { "id": "DerPathologe.60170301.eng.abstr-passage-0", "type": "abstract", "text": [ "In addition to metastasis , the differential diagnosis of multiple pulmonary nodules also includes tuberculosis , sarcoidosis , and silicosis . Rarer diseases such as amyloid tumors , rheumatic nodules and plasma-cell granulomas can be the cause of this finding . This depends on the clinical manifestation . Based on clinical findings of lymphomatoid granulomatosis , the problems in diagnostics using bronchoscopy , mediastinoscopy and thoracoscopy are outlined . Etiology , morphology and differential diagnosis of lymphomatoid granulomatosis versus necrotizing inflammatory or neoplastic lesions are discussed . Treatment and prognosis are described ." ], "offsets": [ [ 0, 655 ] ] } ]
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"DerPathologe.60170301.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "plasma-cell" ], "offsets": [ [ 206, 217 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "DerPathologe.60170301.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "granulomas" ], "offsets": [ [ 218, 228 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018188" } ] }, { "id": "DerPathologe.60170301.eng.abstr-s2-t7", "type": "umlsterm", "text": [ "cause" ], "offsets": [ [ 240, 245 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015127" } ] }, { "id": "DerPathologe.60170301.eng.abstr-s2-t8", "type": "umlsterm", "text": [ "finding" ], "offsets": [ [ 254, 261 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243095" } ] }, { "id": "DerPathologe.60170301.eng.abstr-s2-t9", "type": "umlsterm", "text": [ "rheumatic nodules" ], "offsets": [ [ 184, 201 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035441" } ] }, { "id": "DerPathologe.60170301.eng.abstr-s4-t1", "type": "umlsterm", 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[]
[]
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DerPathologe.60170333.eng.abstr
DerPathologe.60170333.eng.abstr
[ { "id": "DerPathologe.60170333.eng.abstr-passage-0", "type": "abstract", "text": [ "Comparative genomic hybridization ( CGH ) is a new method of screening a tumor for genetic changes . The alterations are classified as DNA gains and losses and reveal a characteristic pattern that includes mutations at the chromosomal and subchromosomal levels . Although DNA from fresh-frozen tissue is recommended as the starting material , archival specimens can also be analyzed . Various examples are presented that illustrate the changes that occur in different tumor entities , and preneoplastic lesions , the differentiation of primary tumors from metastases , and the investigation of tumor cell lines that are resistant to cytostatic drugs . These examples emphasize that CGH can extend the possibilities for genetic diagnosis in tumor pathology ." ], "offsets": [ [ 0, 757 ] ] } ]
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[]
[]
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"DerPathologe.60170333.eng.abstr-s5-t1", "normalized": [] }, { "id": "DerPathologe.60170333.eng.abstr-s4-r27-t12.1-t9.1", "type": "location_of", "arg1_id": "DerPathologe.60170333.eng.abstr-s4-t12", "arg2_id": "DerPathologe.60170333.eng.abstr-s4-t9", "normalized": [] }, { "id": "DerPathologe.60170333.eng.abstr-s4-r28-t10.1-t1.1", "type": "location_of", "arg1_id": "DerPathologe.60170333.eng.abstr-s4-t10", "arg2_id": "DerPathologe.60170333.eng.abstr-s5-t1", "normalized": [] }, { "id": "DerPathologe.60170333.eng.abstr-s5-r1-t1.1-t3.1", "type": "method_of", "arg1_id": "DerPathologe.60170333.eng.abstr-s5-t1", "arg2_id": "DerPathologe.60170333.eng.abstr-s5-t3", "normalized": [] }, { "id": "DerPathologe.60170333.eng.abstr-s5-r3-t1.2-t3.1", "type": "issue_in", "arg1_id": "DerPathologe.60170333.eng.abstr-s5-t1", "arg2_id": "DerPathologe.60170333.eng.abstr-s5-t3", "normalized": [] } ]
DerPathologe.60170342.eng.abstr
DerPathologe.60170342.eng.abstr
[ { "id": "DerPathologe.60170342.eng.abstr-passage-0", "type": "abstract", "text": [ "Comparative genomic hybridization ( CGH ) is a molecular cytogenetic method for the detection of chromosomal imbalances between a tumor and a normal genome . In order to produce quantitative and reproducible results , we developed an image analysis program that allows the detection and mapping of the genetic alterations . The result is represented as a CGH sum karyogram in which the genetic changes are documented as color coded-chromosomes . The aim of our investigation is to correlate the genotype with the phenotype on the basis of CGH sum karyograms and thus to achieve a genetic characterization that will supplement the morphological tumor description ." ], "offsets": [ [ 0, 663 ] ] } ]
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[]
[]
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DerPathologe.60170349.eng.abstr
DerPathologe.60170349.eng.abstr
[ { "id": "DerPathologe.60170349.eng.abstr-passage-0", "type": "abstract", "text": [ "Data in the literature communicated in 63 publications were evaluated in which scintigraphically warm or hot nodules were described as identical to a follicular or papillary carcinoma diagnosed based on histology of the resection specimen , thus suggesting autonomous hyperfunction of a malignant thyroid neoplasia . In the majority of cases , this assumption could not be accepted , or only within strict limits . In these patients , it appeared more likely that the carcinoma was located adjacent to or within a benign hyperfunctioning thyroid area or that large masses of a thyroid carcinoma had only simulated the picture of a hyperfunctioning nodule by suppression of endogenous TSH and thus of the residual parenchyma's function . In other cases , the diagnosis of a hyperfunctioning thyroid carcinoma had to be doubted or rejected owing to the lack of plausibility of the documented morphological findings . At the end of the literature survey , only 10 case descriptions unequivocally verified that , though very rarely , a papillary or follicular thyroid carcinoma may manifest itself as a solitary warm or hot thyroid nodule . Such a scintigraphical finding thus cannot be regarded as proof of benignancy of a given thyroid tumour ." ], "offsets": [ [ 0, 1242 ] ] } ]
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DerPathologe.60170358.eng.abstr
DerPathologe.60170358.eng.abstr
[ { "id": "DerPathologe.60170358.eng.abstr-passage-0", "type": "abstract", "text": [ "The maintenance of a normal skeletal shape and bone mass closely depends on a normal osteoclastic activity , as do bone growth and repair . Thus , the improvement of our means of therapeutic intervention will depend on our better understanding of the molecular basis of bone resorption and of the cellbiology of the osteoclast . This review-article presents our current opinion of the molecular mechanisms of bone resorption by the osteoclast . After describing the morphological features of the osteoclast , aspects as cell mobility , attachment , enzymesynthesis , transmembrane transport , osteoclast differentiation and function , as well as the protooncogenes c-src and c-cbl and their role for bone resorption are presented in detail ." ], "offsets": [ [ 0, 741 ] ] } ]
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[]
[]
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DerPathologe.60170368.eng.abstr
DerPathologe.60170368.eng.abstr
[ { "id": "DerPathologe.60170368.eng.abstr-passage-0", "type": "abstract", "text": [ "Neuroblastoma is the most frequent extracranial solid tumor of early childhood . Histologically and genetically , neuroblastoma represents a heterogeneous group of tumors with significant differences in clinical behavior . In the past , several different characteristic chromosomal aberrations of neuroblastoma have been described , of which a deletion on chromosome 1p and N-myc amplification have been shown to be of major prognostic significance . However , the role of various other nonrandom DNA imbalances in tumor development and progression needs to be clarified . Taking advantage of the recently established comparative genomic hybridization ( CGH ) , we show that this method is able to accurately detect chromosomal imbalances of known prognostic impact . As CGH gives a comprehensive picture of genetic imbalances in just one experiment , it additionally sheds light on other abnormalities of possible prognostic relevance . We therefore recommend further use of this method not only in the field of resarch but also for the purpose of genetic routine diagnostics in neuroblastoma ." ], "offsets": [ [ 0, 1095 ] ] } ]
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[]
[]
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DerPathologe.60170380.eng.abstr
DerPathologe.60170380.eng.abstr
[ { "id": "DerPathologe.60170380.eng.abstr-passage-0", "type": "abstract", "text": [ "Occupational formaldehyde exposure in pathology depends on the efficiency of the ventilation system in use and may reach concentrations considerably above the current threshold limit values . The reduction of formaldehyde exposure by stepwise improvement of the ventilation system at a pathologist's workplace is presented as an example in this paper . Assessment of formaldehyde concentration by personal air sampling at a workplace originally equipped with a hood ventilation system resulted in values of up to 4 ml/m3 in the pathologist's breathing zone . Lowering the ventilation inlet to the working level by connecting the hood to a suction unit via a flexible hose resulted in an effective reduction of formaldehyde exposure to values of about 0.5 ml/m3. This simple and low-cost technical improvement had some uncomfortable side effects , such as current noise and wind chill , which could only be overcome by installing ventilated worktables according to modern technical standards ." ], "offsets": [ [ 0, 992 ] ] } ]
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"DerPathologe.60170380.eng.abstr-s4-t10", "arg2_id": "DerPathologe.60170380.eng.abstr-s4-t4", "normalized": [] }, { "id": "DerPathologe.60170380.eng.abstr-s4-r49-t2.1-t6.1", "type": "treats", "arg1_id": "DerPathologe.60170380.eng.abstr-s4-t2", "arg2_id": "DerPathologe.60170380.eng.abstr-s4-t6", "normalized": [] }, { "id": "DerPathologe.60170380.eng.abstr-s4-r50-t10.1-t2.1", "type": "associated_with", "arg1_id": "DerPathologe.60170380.eng.abstr-s4-t10", "arg2_id": "DerPathologe.60170380.eng.abstr-s4-t2", "normalized": [] } ]
DerPathologe.60170391.eng.abstr
DerPathologe.60170391.eng.abstr
[ { "id": "DerPathologe.60170391.eng.abstr-passage-0", "type": "abstract", "text": [ "We report two cases of patients ( one 65 and one 43 years of age , respectively ) who died of Streptococcus-viridans induced endocarditis of the aortic valve with perforation into the right atrium . Whereas perforation in Staphylococcus-induced endocarditis is a common complication , it occurs rarely in Streptococcus-induced endocarditis . Because of its uncharacteristic symptoms , the endocarditis was clinically unknwon in both cases and was recognized to be the cause of death only at autopsy . To reduce the large number of complications in patients suffering from endocarditis , it is necessary to confirm the diagnosis as soon as possible if endocarditis might be suspected ." ], "offsets": [ [ 0, 684 ] ] } ]
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[]
[]
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DerPathologe.60170405.eng.abstr
DerPathologe.60170405.eng.abstr
[ { "id": "DerPathologe.60170405.eng.abstr-passage-0", "type": "abstract", "text": [ "Systemic lupus erythematosus ( SLE ) is a chronic autoimmune disorder characterized by the synthesis of antinuclear antibodies . Nucleosomes - the disc-like structural units of chromatin , composed of histones and DNA - are the primary antigenic structure that induces the formation of complement-activating antigen-antibody complexes in basement membranes . The autoreactivity in SLE has been elucidated in drug-induced SLE : hypomethylation of DNA leads to overexpression of integrin CD11a/CD18, increased binding of T-cells to macrophages and B-cells , a higher rate of apoptosis of macrophages , and elevated B-cell activity with consecutive production of autoantibodies . Disturbances of apoptosis ( e . g . mutation of Fas gene ) are relevant also in non-drug-induced SLE . The morphologic diagnosis - by light microscopy , immunohistology and electron microscopy - of skin and renal biopsies can confirm the diagnosis and help in prognostic assessment as well as therapeutic decisions in SLE . The value of the morphologic diagnosis in SLE is enhanced by reporting semiquantitative scores of disease activity and chronicity . The antiphospholipid syndrome ( APS ) is characterized by thrombosis , thrombocytopenia , recurrent fetal loss and antiphospholipid antibodies . APS associated with SLE or other systemic autoimmune diseases has been termed secondary APS . Antibodies in APS are directed against phospholipids and phospholipid-protein complexes . One of these proteins is 2-glycoprotein 1. An important mechanism of the increased rate of thrombosis in APS is probably the inhibition of the protein C-catalyzed inactivation of clotting factors V and VIII . Venous thrombosis with recurrent pulmonary emboli and arterial thrombi in brain , heart and kidney ( thrombotic microangiopathy ) can lead to divergent clinical manifestations in APS ." ], "offsets": [ [ 0, 1855 ] ] } ]
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DerPathologe.60170417.eng.abstr
DerPathologe.60170417.eng.abstr
[ { "id": "DerPathologe.60170417.eng.abstr-passage-0", "type": "abstract", "text": [ "With the introduction of the terms atypical adenomatous hyperplasia ( AAH ) and prostatic intraepithelial neoplasia ( PIN ) , the spectrum of prostatic diseases has been distinctly enlarged . With more sophisticated diagnostics , however , diagnostic and differential diagnostic problems grow more important . At the institute of pathology in Singen , this issue is reflected by the increasing use of the uropathologic consultation service since 1989. The purpose of this paper is to demonstrate typical diagnostic and differential diagnostic problems in the pathology of the prostate on the basis of this consultation service . 573 submitted prostatic cases were evaluated and the final diagnoses were compared to the preliminary diagnoses by the primary pathologist . Frequent differences could be detected in the 3 following groups : 1. Differentiation of sclerosing adenosis versus well differentiated adenocarcinoma 2. Differentiation of AAH versus well differentiated adenocarcinoma 3. Differentiation of high grade PIN versus poorly differentiated adenocarcinoma 4. Differentiation of glandular G II a versus G II b carcinomas . Possible decision guidelines are presented ." ], "offsets": [ [ 0, 1180 ] ] } ]
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[]
[]
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DerPathologe.60170425.eng.abstr
DerPathologe.60170425.eng.abstr
[ { "id": "DerPathologe.60170425.eng.abstr-passage-0", "type": "abstract", "text": [ "Using 8 different monoclonal antibodies , immunohistology was performed on 36 follicular adenomas and on 28 follicular , 34 papillary , 27 medullary and 29 anaplastic carcinomas of the thyroid . The panel of antibodies was directed against broad-spectrum cytokeratins ( pan-CK , antibody lu-5), against basic and acid high-molecular-weight CK of types 1 , 5 , 10 and 14 , against basic ( 5 and 6 ) and acid high-molecular-weight CK ( 13 ) and against basic ( 7 and 8 ) and acid low-molecular-weight CK ( 19 and 20 ) . With the exception of a large number of anaplastic carcinomas , nearly all other tumours exhibited strong immunoreactivity with antibodies against pan-CK , CK 8 and CK 19. CK 20 expression was exclusively shown for 2 medullary carcinomas . Reactivity for high-molecular-weight CK could only , each time focally , be demonstrated for 14 papillary and 2 follicular carcinomas and for 2 anaplastic carcinomas with partial squamous differentiation . Thirteen anaplastic carcinomas were not decorated by any of the CK antibodies applied . CK 7 staining exceeding the staining of individual cells was observed in 26 papillary cancers . In contrast , such a finding could only be obtained with each one follicular adenoma , medullary carcinoma and anaplastic carcinoma and with 5 follicular carcinomas . These results confirm earlier studies in that CK 20 expression among thyroid tumours is restricted to the neuroendocrine medullary carcinomas and that in a larger percentage of anaplastic thyroid carcinomas an epithelial phenotype can not be demonstrated even upon using broad-spectrum CK antibodies . New is the finding that there exist considerable differences between papillary carcinomas and all other non-papillary thyroid tumours regarding CK 7 expression . This result might be of differential diagnostic value for the distinction of follicular and papillary thyroid neoplasias which sometimes have an overlapping histological pattern ." ], "offsets": [ [ 0, 1958 ] ] } ]
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"DerPathologe.60170425.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "follicular adenomas" ], "offsets": [ [ 78, 97 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0205647" } ] }, { "id": "DerPathologe.60170425.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "anaplastic carcinomas" ], "offsets": [ [ 156, 177 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0205696" } ] }, { "id": "DerPathologe.60170425.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "antibodies" ], "offsets": [ [ 208, 218 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003241" } ] }, { "id": "DerPathologe.60170425.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "cytokeratins" ], "offsets": [ [ 255, 267 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010803" } ] }, { "id": "DerPathologe.60170425.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "antibody" ], "offsets": [ [ 279, 287 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003241" } ] }, { "id": "DerPathologe.60170425.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "acid" ], "offsets": [ [ 313, 317 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001128" } ] }, { "id": "DerPathologe.60170425.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "acid" ], "offsets": [ [ 402, 406 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001128" } ] }, { "id": "DerPathologe.60170425.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "acid" ], "offsets": [ [ 473, 477 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001128" } ] }, { "id": "DerPathologe.60170425.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "carcinomas" ], "offsets": [ [ 569, 579 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007097" } ] }, { "id": "DerPathologe.60170425.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "tumours" ], "offsets": [ [ 599, 606 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.60170425.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "antibodies" ], "offsets": [ [ 646, 656 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003241" } ] }, { "id": "DerPathologe.60170425.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "carcinomas" ], "offsets": [ [ 745, 755 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007097" } ] }, { "id": "DerPathologe.60170425.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "anaplastic carcinomas" ], "offsets": [ [ 558, 579 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0205696" } ] }, { "id": "DerPathologe.60170425.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "medullary carcinomas" ], "offsets": [ [ 735, 755 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0206693" } ] }, { "id": "DerPathologe.60170425.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "time" ], "offsets": [ [ 816, 820 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040223" } ] }, { "id": "DerPathologe.60170425.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "carcinomas" ], "offsets": [ [ 881, 891 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007097" } ] }, { "id": "DerPathologe.60170425.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "carcinomas" ], "offsets": [ [ 913, 923 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007097" } ] }, { "id": "DerPathologe.60170425.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "follicular carcinomas" ], "offsets": [ [ 870, 891 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0206682" } ] }, { "id": "DerPathologe.60170425.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "anaplastic carcinomas" ], "offsets": [ [ 902, 923 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0205696" } ] }, { "id": "DerPathologe.60170425.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "carcinomas" ], "offsets": [ [ 984, 994 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007097" } ] }, { "id": "DerPathologe.60170425.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "antibodies" ], "offsets": [ [ 1031, 1041 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003241" } ] }, { "id": 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"papillary carcinomas" ], "offsets": [ [ 1686, 1706 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007133" } ] }, { "id": "DerPathologe.60170425.eng.abstr-s9-t6", "type": "umlsterm", "text": [ "thyroid tumours" ], "offsets": [ [ 1735, 1750 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040136" } ] }, { "id": "DerPathologe.60170425.eng.abstr-s10-t1", "type": "umlsterm", "text": [ "diagnostic" ], "offsets": [ [ 1816, 1826 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerPathologe.60170425.eng.abstr-s10-t2", "type": "umlsterm", "text": [ "value" ], "offsets": [ [ 1827, 1832 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042295" } ] }, { "id": "DerPathologe.60170425.eng.abstr-s10-t3", "type": "umlsterm", "text": [ "thyroid" ], "offsets": [ [ 1881, 1888 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040132" }, { "db_name": "UMLS", "db_id": "C0040134" } ] }, { "id": "DerPathologe.60170425.eng.abstr-s10-t4", "type": "umlsterm", "text": [ "neoplasias" ], "offsets": [ [ 1889, 1899 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] } ]
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"DerPathologe.60170425.eng.abstr-s9-t5", "normalized": [] }, { "id": "DerPathologe.60170425.eng.abstr-s9-r7-t3.1-t4.1", "type": "location_of", "arg1_id": "DerPathologe.60170425.eng.abstr-s10-t3", "arg2_id": "DerPathologe.60170425.eng.abstr-s10-t4", "normalized": [] }, { "id": "DerPathologe.60170425.eng.abstr-s9-r8-t3.2-t6.1", "type": "diagnoses", "arg1_id": "DerPathologe.60170425.eng.abstr-s10-t3", "arg2_id": "DerPathologe.60170425.eng.abstr-s9-t6", "normalized": [] }, { "id": "DerPathologe.60170425.eng.abstr-s9-r9-t3.2-t4.1", "type": "affects", "arg1_id": "DerPathologe.60170425.eng.abstr-s10-t3", "arg2_id": "DerPathologe.60170425.eng.abstr-s10-t4", "normalized": [] }, { "id": "DerPathologe.60170425.eng.abstr-s9-r11-t3.2-t1.1", "type": "diagnoses", "arg1_id": "DerPathologe.60170425.eng.abstr-s10-t3", "arg2_id": "DerPathologe.60170425.eng.abstr-s10-t1", "normalized": [] }, { "id": "DerPathologe.60170425.eng.abstr-s9-r12-t3.1-t1.1", "type": "location_of", "arg1_id": "DerPathologe.60170425.eng.abstr-s10-t3", "arg2_id": "DerPathologe.60170425.eng.abstr-s10-t1", "normalized": [] }, { "id": "DerPathologe.60170425.eng.abstr-s9-r13-t3.2-t4.1", "type": "diagnoses", "arg1_id": "DerPathologe.60170425.eng.abstr-s10-t3", "arg2_id": "DerPathologe.60170425.eng.abstr-s10-t4", "normalized": [] }, { "id": "DerPathologe.60170425.eng.abstr-s9-r14-t1.1-t6.1", "type": "associated_with", "arg1_id": "DerPathologe.60170425.eng.abstr-s10-t1", "arg2_id": "DerPathologe.60170425.eng.abstr-s9-t6", "normalized": [] }, { "id": "DerPathologe.60170425.eng.abstr-s9-r16-t1.1-t5.1", "type": "associated_with", "arg1_id": "DerPathologe.60170425.eng.abstr-s10-t1", "arg2_id": "DerPathologe.60170425.eng.abstr-s9-t5", "normalized": [] }, { "id": "DerPathologe.60170425.eng.abstr-s9-r17-t1.1-t4.1", "type": "associated_with", "arg1_id": "DerPathologe.60170425.eng.abstr-s10-t1", "arg2_id": "DerPathologe.60170425.eng.abstr-s10-t4", "normalized": [] }, { "id": "DerPathologe.60170425.eng.abstr-s10-r1-t1.1-t4.1", "type": "location_of", "arg1_id": "DerPathologe.60170425.eng.abstr-s10-t1", "arg2_id": "DerPathologe.60170425.eng.abstr-s10-t4", "normalized": [] }, { "id": "DerPathologe.60170425.eng.abstr-s10-r2-t4.1-t3.2", "type": "produces", "arg1_id": "DerPathologe.60170425.eng.abstr-s10-t4", "arg2_id": "DerPathologe.60170425.eng.abstr-s10-t3", "normalized": [] }, { "id": "DerPathologe.60170425.eng.abstr-s10-r3-t3.2-t4.1", "type": "affects", "arg1_id": "DerPathologe.60170425.eng.abstr-s10-t3", "arg2_id": "DerPathologe.60170425.eng.abstr-s10-t4", "normalized": [] }, { "id": "DerPathologe.60170425.eng.abstr-s10-r4-t3.2-t4.1", "type": "diagnoses", "arg1_id": "DerPathologe.60170425.eng.abstr-s10-t3", "arg2_id": "DerPathologe.60170425.eng.abstr-s10-t4", "normalized": [] }, { "id": "DerPathologe.60170425.eng.abstr-s10-r5-t1.1-t3.2", "type": "produces", "arg1_id": "DerPathologe.60170425.eng.abstr-s10-t1", "arg2_id": "DerPathologe.60170425.eng.abstr-s10-t3", "normalized": [] }, { "id": "DerPathologe.60170425.eng.abstr-s10-r6-t3.2-t1.1", "type": "disrupts", "arg1_id": "DerPathologe.60170425.eng.abstr-s10-t3", "arg2_id": "DerPathologe.60170425.eng.abstr-s10-t1", "normalized": [] } ]
DerPathologe.60170433.eng.abstr
DerPathologe.60170433.eng.abstr
[ { "id": "DerPathologe.60170433.eng.abstr-passage-0", "type": "abstract", "text": [ "We looked for micrometastases in the axillary lymph nodes of 163 women with breast carcinoma , using monoclonal anti-cytokeratin antibodies . We found 26 micrometastases ( 2.1 % ) in node-negative patients ( n = 17 ) . Life-table analysis after 3 years detected the conformity of this group with the N1 group with regard to overall survival and distant-metastasis-free survival ." ], "offsets": [ [ 0, 379 ] ] } ]
[ { "id": "DerPathologe.60170433.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "lymph" ], "offsets": [ [ 46, 51 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024202" } ] }, { "id": "DerPathologe.60170433.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "women" ], "offsets": [ [ 65, 70 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043210" } ] }, { "id": "DerPathologe.60170433.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "breast" ], "offsets": [ [ 76, 82 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006141" }, { "db_name": "UMLS", "db_id": "C0006142" } ] }, { "id": "DerPathologe.60170433.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "carcinoma" ], "offsets": [ [ 83, 92 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007097" } ] }, { "id": "DerPathologe.60170433.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "anti-cytokeratin" ], "offsets": [ [ 112, 128 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003209" }, { "db_name": "UMLS", "db_id": "C0003204" } ] }, { "id": "DerPathologe.60170433.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "anti-cytokeratin" ], "offsets": [ [ 112, 128 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010803" } ] }, { "id": "DerPathologe.60170433.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "antibodies" ], "offsets": [ [ 129, 139 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003241" } ] }, { "id": "DerPathologe.60170433.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "lymph nodes" ], "offsets": [ [ 46, 57 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024204" } ] }, { "id": "DerPathologe.60170433.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 197, 205 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerPathologe.60170433.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "Life-table" ], "offsets": [ [ 219, 229 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376558" } ] }, { "id": "DerPathologe.60170433.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "analysis" ], "offsets": [ [ 230, 238 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002778" } ] }, { "id": "DerPathologe.60170433.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "overall" ], "offsets": [ [ 324, 331 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0282416" } ] }, { "id": "DerPathologe.60170433.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "survival" ], "offsets": [ [ 332, 340 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220921" }, { "db_name": "UMLS", "db_id": "C0038952" } ] }, { "id": "DerPathologe.60170433.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "distant-metastasis-free" ], "offsets": [ [ 345, 368 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027627" } ] }, { "id": "DerPathologe.60170433.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "survival" ], "offsets": [ [ 369, 377 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220921" }, { "db_name": "UMLS", "db_id": "C0038952" } ] } ]
[]
[]
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"DerPathologe.60170433.eng.abstr-s3-t6", "normalized": [] }, { "id": "DerPathologe.60170433.eng.abstr-s1-r6-t1.1-t8.1", "type": "connected_to", "arg1_id": "DerPathologe.60170433.eng.abstr-s3-t1", "arg2_id": "DerPathologe.60170433.eng.abstr-s1-t8", "normalized": [] }, { "id": "DerPathologe.60170433.eng.abstr-s1-r7-t6.1-t3.2", "type": "affects", "arg1_id": "DerPathologe.60170433.eng.abstr-s3-t6", "arg2_id": "DerPathologe.60170433.eng.abstr-s1-t3", "normalized": [] }, { "id": "DerPathologe.60170433.eng.abstr-s1-r8-t5.1-t3.1", "type": "disrupts", "arg1_id": "DerPathologe.60170433.eng.abstr-s3-t5", "arg2_id": "DerPathologe.60170433.eng.abstr-s3-t3", "normalized": [] }, { "id": "DerPathologe.60170433.eng.abstr-s1-r9-t3.2-t6.1", "type": "produces", "arg1_id": "DerPathologe.60170433.eng.abstr-s1-t3", "arg2_id": "DerPathologe.60170433.eng.abstr-s3-t6", "normalized": [] }, { "id": "DerPathologe.60170433.eng.abstr-s1-r10-t1.1-t6.1", "type": "consists_of", "arg1_id": "DerPathologe.60170433.eng.abstr-s3-t1", "arg2_id": "DerPathologe.60170433.eng.abstr-s3-t6", "normalized": [] }, { "id": "DerPathologe.60170433.eng.abstr-s1-r11-t5.2-t3.1", "type": "disrupts", "arg1_id": "DerPathologe.60170433.eng.abstr-s1-t5", "arg2_id": "DerPathologe.60170433.eng.abstr-s3-t3", "normalized": [] }, { "id": "DerPathologe.60170433.eng.abstr-s1-r12-t6.1-t3.1", "type": "disrupts", "arg1_id": "DerPathologe.60170433.eng.abstr-s3-t6", "arg2_id": "DerPathologe.60170433.eng.abstr-s3-t3", "normalized": [] }, { "id": "DerPathologe.60170433.eng.abstr-s1-r13-t5.1-t6.1", "type": "interacts_with", "arg1_id": "DerPathologe.60170433.eng.abstr-s3-t5", "arg2_id": "DerPathologe.60170433.eng.abstr-s3-t6", "normalized": [] }, { "id": "DerPathologe.60170433.eng.abstr-s1-r14-t5.1-t3.2", "type": "diagnoses", "arg1_id": "DerPathologe.60170433.eng.abstr-s3-t5", "arg2_id": "DerPathologe.60170433.eng.abstr-s1-t3", "normalized": [] }, { "id": "DerPathologe.60170433.eng.abstr-s1-r15-t6.1-t5.2", "type": "interacts_with", "arg1_id": "DerPathologe.60170433.eng.abstr-s3-t6", "arg2_id": "DerPathologe.60170433.eng.abstr-s1-t5", "normalized": [] }, { "id": "DerPathologe.60170433.eng.abstr-s1-r16-t5.2-t6.1", "type": "interacts_with", "arg1_id": "DerPathologe.60170433.eng.abstr-s1-t5", "arg2_id": "DerPathologe.60170433.eng.abstr-s3-t6", "normalized": [] }, { "id": "DerPathologe.60170433.eng.abstr-s1-r17-t5.2-t3.2", "type": "diagnoses", "arg1_id": "DerPathologe.60170433.eng.abstr-s1-t5", "arg2_id": "DerPathologe.60170433.eng.abstr-s1-t3", "normalized": [] }, { "id": "DerPathologe.60170433.eng.abstr-s1-r18-t3.2-t1.1", "type": "produces", "arg1_id": "DerPathologe.60170433.eng.abstr-s1-t3", "arg2_id": "DerPathologe.60170433.eng.abstr-s3-t1", "normalized": [] }, { "id": "DerPathologe.60170433.eng.abstr-s1-r19-t6.1-t3.2", "type": "indicates", "arg1_id": "DerPathologe.60170433.eng.abstr-s3-t6", "arg2_id": "DerPathologe.60170433.eng.abstr-s1-t3", "normalized": [] }, { "id": "DerPathologe.60170433.eng.abstr-s1-r20-t3.1-t3.2", "type": "location_of", "arg1_id": "DerPathologe.60170433.eng.abstr-s3-t3", "arg2_id": "DerPathologe.60170433.eng.abstr-s1-t3", "normalized": [] }, { "id": "DerPathologe.60170433.eng.abstr-s1-r21-t6.1-t5.1", "type": "interacts_with", "arg1_id": "DerPathologe.60170433.eng.abstr-s3-t6", "arg2_id": "DerPathologe.60170433.eng.abstr-s3-t5", "normalized": [] }, { "id": "DerPathologe.60170433.eng.abstr-s1-r22-t8.1-t3.2", "type": "location_of", "arg1_id": "DerPathologe.60170433.eng.abstr-s1-t8", "arg2_id": "DerPathologe.60170433.eng.abstr-s1-t3", "normalized": [] }, { "id": "DerPathologe.60170433.eng.abstr-s1-r23-t1.1-t3.2", "type": "causes", "arg1_id": "DerPathologe.60170433.eng.abstr-s3-t1", "arg2_id": "DerPathologe.60170433.eng.abstr-s1-t3", "normalized": [] }, { "id": "DerPathologe.60170433.eng.abstr-s1-r24-t5.1-t8.1", "type": "disrupts", "arg1_id": "DerPathologe.60170433.eng.abstr-s3-t5", "arg2_id": "DerPathologe.60170433.eng.abstr-s1-t8", "normalized": [] }, { "id": "DerPathologe.60170433.eng.abstr-s1-r25-t3.1-t1.1", "type": "connected_to", "arg1_id": "DerPathologe.60170433.eng.abstr-s3-t3", "arg2_id": "DerPathologe.60170433.eng.abstr-s3-t1", "normalized": [] }, { "id": "DerPathologe.60170433.eng.abstr-s1-r26-t8.1-t6.1", "type": "produces", "arg1_id": "DerPathologe.60170433.eng.abstr-s1-t8", "arg2_id": "DerPathologe.60170433.eng.abstr-s3-t6", "normalized": [] }, { "id": "DerPathologe.60170433.eng.abstr-s1-r27-t3.2-t2.1", "type": "associated_with", "arg1_id": "DerPathologe.60170433.eng.abstr-s1-t3", "arg2_id": "DerPathologe.60170433.eng.abstr-s3-t2", "normalized": [] }, { "id": "DerPathologe.60170433.eng.abstr-s1-r28-t5.2-t8.1", "type": "disrupts", "arg1_id": "DerPathologe.60170433.eng.abstr-s1-t5", "arg2_id": "DerPathologe.60170433.eng.abstr-s1-t8", "normalized": [] }, { "id": "DerPathologe.60170433.eng.abstr-s3-r1-t2.1-t5.1", "type": "associated_with", "arg1_id": "DerPathologe.60170433.eng.abstr-s3-t2", "arg2_id": "DerPathologe.60170433.eng.abstr-s3-t5", "normalized": [] }, { "id": "DerPathologe.60170433.eng.abstr-s3-r2-t2.1-t6.1", "type": "isa", "arg1_id": "DerPathologe.60170433.eng.abstr-s3-t2", "arg2_id": "DerPathologe.60170433.eng.abstr-s3-t6", "normalized": [] }, { "id": "DerPathologe.60170433.eng.abstr-s3-r3-t5.1-t2.1", "type": "associated_with", "arg1_id": "DerPathologe.60170433.eng.abstr-s3-t5", "arg2_id": "DerPathologe.60170433.eng.abstr-s3-t2", "normalized": [] } ]
DerPathologe.60170440.eng.abstr
DerPathologe.60170440.eng.abstr
[ { "id": "DerPathologe.60170440.eng.abstr-passage-0", "type": "abstract", "text": [ "Tumor of the follicular infundibulum is a rare proliferation of cells and its histogenesis or differentiation at the morphological level has been the subject of some controversy . In recent years cytokeratins have been recognized as important markers of epithelial differentiation , and of late new retrieval methods have meant it is possible to detect them in formalin-fixed and paraffin-embedded tissue . Four patients were studied , the ages ranging between the 2 nd and 7 th decade . The tumors were all located in the head and neck and in one case the lesion developed in a pre-existing sebaceous nevus . The morphological investigation revealed a flat , proliferation of polygonal , pale eosinophilic cells connected to epidermis or follicular infundibulum and with a centrally located nucleus . In addition , a few ductal structures resembling sebaceous ducts were seen and in one case a hair germ papilla and a follicular papilla was noted . Immunohistochemical investigations with antibodies against cytokeratins revealed differentiation comparable to that in the fetal follicular isthmus and , in one case , also differentiation in keeping with the fetal follicular infundibulum ." ], "offsets": [ [ 0, 1190 ] ] } ]
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[]
[]
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DerPathologe.60170446.eng.abstr
DerPathologe.60170446.eng.abstr
[ { "id": "DerPathologe.60170446.eng.abstr-passage-0", "type": "abstract", "text": [ "Differentiation of a cutaneous lymphoma from a reactive lymphoid infiltrate is a demanding challenge for the pathologist . In this retrospective study we examined 24 paraffin-embedded tissue samples from lesions diagnosed as lymphomas and 7 control samples of skin affected by benign changes and with pronounced lymphoid infiltrates for clonal rearrangement of the gamma T-cellreceptor . Using PCR technology we demonstrated clonality in 22 cases of lymphoma ( 92 % ) . Thus , the primer combination used in this study covering the four main groups ( I-IV ) of the variable region of the gamma T-cell receptor gene allows high sensitivity . No clonality was demonstrable in any of the 7 control cases . This study demonstrates the growing importance of PCR technology for the diagnosis of lymphoma ." ], "offsets": [ [ 0, 799 ] ] } ]
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[]
[]
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DerPathologe.60170451.eng.abstr
DerPathologe.60170451.eng.abstr
[ { "id": "DerPathologe.60170451.eng.abstr-passage-0", "type": "abstract", "text": [ "The intensity of DNA degradation in fixed tissues is dependent on the fixation solution and the fixation time . The aim of this study was the investigation of DNA degradation over fixation times of up to 70 days in different tissues ( muscle , brain , liver , bone ) and with different formalin concentration ( 2 % , 4 % , 8 % ; unbuffered ) . An additional test was performed to see whether the fixed tissues could be individualized using PCR analysis . The smallest amounts of DNA were extracted from liver and brain and the largest from muscle and bone . The amount of DNA that could be extracted decreased with increasing formalin concentration , while at the same time DNA degradation increased . With the PCR-VNTR system HUMTH 01 , all fixed samples could be typed regardless of the fixation time and the formalin concentration ." ], "offsets": [ [ 0, 835 ] ] } ]
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"aim" ], "offsets": [ [ 116, 119 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0108800" } ] }, { "id": "DerPathologe.60170451.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "DNA" ], "offsets": [ [ 159, 162 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012854" } ] }, { "id": "DerPathologe.60170451.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "degradation" ], "offsets": [ [ 163, 174 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243125" } ] }, { "id": "DerPathologe.60170451.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "times" ], "offsets": [ [ 189, 194 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040223" } ] }, { "id": "DerPathologe.60170451.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "tissues" ], "offsets": [ [ 225, 232 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040300" } ] }, { "id": "DerPathologe.60170451.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "muscle" ], "offsets": [ [ 235, 241 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026845" } ] }, { "id": "DerPathologe.60170451.eng.abstr-s2-t7", "type": "umlsterm", "text": [ "brain" ], "offsets": [ [ 244, 249 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0153633" }, { "db_name": "UMLS", "db_id": "C0006104" }, { "db_name": "UMLS", "db_id": "C0496899" } ] }, { "id": "DerPathologe.60170451.eng.abstr-s2-t8", "type": "umlsterm", "text": [ "liver" ], "offsets": [ [ 252, 257 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0345904" }, { "db_name": "UMLS", "db_id": "C0023884" } ] }, { "id": "DerPathologe.60170451.eng.abstr-s2-t9", "type": "umlsterm", "text": [ "bone" ], "offsets": [ [ 260, 264 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0262950" } ] }, { "id": "DerPathologe.60170451.eng.abstr-s2-t10", "type": "umlsterm", "text": [ "formalin" ], "offsets": [ [ 286, 294 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016564" } ] }, { "id": "DerPathologe.60170451.eng.abstr-s2-t11", "type": "umlsterm", "text": [ "concentration" ], "offsets": [ [ 295, 308 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086045" } ] }, { "id": "DerPathologe.60170451.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "test" ], "offsets": [ [ 358, 362 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0076174" } ] }, { "id": "DerPathologe.60170451.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "tissues" ], "offsets": [ [ 402, 409 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040300" } ] }, { "id": "DerPathologe.60170451.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "PCR" ], "offsets": [ [ 440, 443 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032520" } ] }, { "id": "DerPathologe.60170451.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "analysis" ], "offsets": [ [ 444, 452 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002778" } ] }, { "id": "DerPathologe.60170451.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "DNA" ], "offsets": [ [ 479, 482 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012854" } ] }, { "id": "DerPathologe.60170451.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "liver" ], "offsets": [ [ 503, 508 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0345904" }, { "db_name": "UMLS", "db_id": "C0023884" } ] }, { "id": "DerPathologe.60170451.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "brain" ], "offsets": [ [ 513, 518 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0153633" }, { "db_name": "UMLS", "db_id": "C0006104" }, { "db_name": "UMLS", "db_id": "C0496899" } ] }, { "id": "DerPathologe.60170451.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "muscle" ], "offsets": [ [ 540, 546 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026845" } ] }, { "id": "DerPathologe.60170451.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "bone" ], "offsets": [ [ 551, 555 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0262950" } ] }, { "id": "DerPathologe.60170451.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "DNA" ], "offsets": [ [ 572, 575 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012854" } ] }, { "id": "DerPathologe.60170451.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "formalin" ], "offsets": [ [ 626, 634 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016564" } ] }, { "id": "DerPathologe.60170451.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "concentration" ], "offsets": [ [ 635, 648 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086045" } ] }, { "id": "DerPathologe.60170451.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "time" ], "offsets": [ [ 669, 673 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040223" } ] }, { "id": "DerPathologe.60170451.eng.abstr-s5-t5", "type": "umlsterm", "text": [ "DNA" ], "offsets": [ [ 674, 677 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012854" } ] }, { "id": "DerPathologe.60170451.eng.abstr-s5-t6", "type": "umlsterm", "text": [ "degradation" ], "offsets": [ [ 678, 689 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243125" } ] }, { "id": "DerPathologe.60170451.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "time" ], "offsets": [ [ 798, 802 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040223" } ] }, { "id": "DerPathologe.60170451.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "formalin" ], "offsets": [ [ 811, 819 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016564" } ] }, { "id": "DerPathologe.60170451.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "concentration" ], "offsets": [ [ 820, 833 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086045" } ] } ]
[]
[]
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DerPathologe.60170462.eng.abstr
DerPathologe.60170462.eng.abstr
[ { "id": "DerPathologe.60170462.eng.abstr-passage-0", "type": "abstract", "text": [ "Tuberous sclerosis ( McKusick number : 19110 ) is well documented as an inheritable autosomal dominant disorder . On the occasion of results of an autopsy of a male fetus ( 1950 g , 29th gestational week ) we report on the very early onset of a giant cell astrocytoma ( microcalzified focally ) and a cystic kidney disorder which in association with this phacomatosis is described first for this age . Thus , based on sonography there is a new differential diagnosis for the weighty prenatal diagnosis of a \" Potter syndrome \" or of \" cystic kidneys \" . Moreover , on a chromosomal level we discuss possible connections between tuberous sklerosis and distinct forms of autosomal dominant polycystic kidney disease , ADPKD ." ], "offsets": [ [ 0, 723 ] ] } ]
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"disorder" ], "offsets": [ [ 315, 323 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerPathologe.60170462.eng.abstr-s2-t9", "type": "umlsterm", "text": [ "association" ], "offsets": [ [ 333, 344 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004083" } ] }, { "id": "DerPathologe.60170462.eng.abstr-s2-t10", "type": "umlsterm", "text": [ "phacomatosis" ], "offsets": [ [ 355, 367 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0041341" } ] }, { "id": "DerPathologe.60170462.eng.abstr-s2-t11", "type": "umlsterm", "text": [ "age" ], "offsets": [ [ 396, 399 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001792" }, { "db_name": "UMLS", "db_id": "C0001811" } ] }, { "id": "DerPathologe.60170462.eng.abstr-s2-t12", "type": "umlsterm", "text": [ "giant cell" ], "offsets": [ [ 245, 255 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017526" } ] }, { "id": "DerPathologe.60170462.eng.abstr-s2-t13", "type": "umlsterm", "text": [ "cystic kidney" ], 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[]
[]
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DerPathologe.60170471.eng.abstr
DerPathologe.60170471.eng.abstr
[ { "id": "DerPathologe.60170471.eng.abstr-passage-0", "type": "abstract", "text": [ "Acute leptospirosis in Europe ( Weil's disease ) is a rare and in more than 90 % of the cases undiagnosed febrile , self-limited disease . We report the case of a 39-year-old sewerage worker , who was admitted to our hospital with fever , jaundice , pain in his calves and acute renal failure . Serology revealed elevated antibody titers against Leptospira canicola , L. icterhaemorrhagica and L. sejroe . The patient developed disseminated intravascular coagulation ( DIC ) with diffuse gastrointestinal bleeding due to thrombocytopenia . The ECG showed atrial fibrillation with irregularly irregular rhythm . Cardiac arrest developed , most likely due to hypoxia , with a drop in the blood pressure . Despite immediate resuscitation efforts the patient developed severe hypoxic brain damage and died a few days later . Autopsy disclosed histologic signs of a generalized leptospiral infection , signs of shock and within the lungs a necrotizing herpes simplex virus pneumonia causing the death of the patient . The virus pneumonia most probably was caused by retrograde canalicular dissemination of oral secretions since herpetic tracheitis and esophagitis were found and herpetic lesions were readily identified on the lips and tongue . A medical opinion asked for by the professional association having liability for occupational safety and insurance was given , the disease being recognized as an occupational disease ." ], "offsets": [ [ 0, 1424 ] ] } ]
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DerPathologe.70180003.eng.abstr
DerPathologe.70180003.eng.abstr
[ { "id": "DerPathologe.70180003.eng.abstr-passage-0", "type": "abstract", "text": [ "This review emphazises the pathology of premalignant ductal breast diseases and its practical relevance to the patients management . The histological criteria for recognizing Ductal Hyperplasia ( DH ) are now well established . These include an intraluminal heterogenous proliferation of glandular cells positive for keratins 8/18/19 and epithelial cells with expression of keratins 5/6/14 . As a hyperplastic process the epithelial cells disclose an haphazard irregular growth with slit like irregular lumina ( fenestrated growth pattern ) . The florid DH indicates a slight subsequent increased risk for cancer development . Our knowledge of the nature of noninvasive ductal neoplasia continues to evolve . Recent molecular genetic and immunohistochemical efforts have disclosed that atypical ductal hyperplasia ( ADH ) constituted a clonal neoplastic proliferation of an epithelial cell . Histological hallmarks of ADH are their cytologic features of uniformity and monotony of proliferation of cells and its micropapillary , cibriform or solid growth pattern . So from histology ADH simulates the highly differentiated DCIS , but can be distinguished from the latter quantitavely by the aggregate cross sectional diameter or the number of ducts that are completely involved by the atypical proliferation . ADH indicates a few fold subsequent increased risk for developing carcinoma . So this leson requires a close follow up with 3 to 4 examinations per year and annual mammograms . Ductal carcinoma in situ ( DCIS ) consists of cytologically malignant cells in the parenchyma that have not invaded into the stroma . Recent studies have shown that DCIS is a heterogenous group of tumors . Attempts have been made to classify it into histologic patterns , nuclear grades , tumors with or without comedo-necroses etc. We can draw the conclusion from several studies that the most important histologic feature is the nuclear grade . Holland et al. have suggested a very useful classification scheme that includes nuclear grade and histological features . The modifiers of treatment are as follows : 1. nuclear grade or differentiation of the DCIS 2. extention of the lesion 3. excision with clear margins So efforts to classify DCIS underscore the central role of pathology in determining the grade of the DCIS , its size and the adequacy of the surgical excision in terms of free margins . All three parameters are included in a score system of the Van Nuys Prognostic Index ." ], "offsets": [ [ 0, 2478 ] ] } ]
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DerPathologe.70180019.eng.abstr
DerPathologe.70180019.eng.abstr
[ { "id": "DerPathologe.70180019.eng.abstr-passage-0", "type": "abstract", "text": [ "DNA flow cytometry ( FCM ) has become a routine method in breast cancer diagnosis for evaluation of ploidy and proliferation kinetics ( cell cycle analysis ) . Image cytometry is less practicable and provides less information than flow cytometry . An optimized technique with a low coefficient of variation is required for optimal results in flow cytometry . The S-phase fraction and the proliferation index ( sum of S-phase fraction and G2M fraction ) provide prognostic and therapeutically relevant information . A profound knowledge of the technique and its limitations is indispensable for the interpretation of FCM results . It remains to be established whether immunohistological evaluation of cell proliferation has the same prognostic value . Future developments are to be expected from multiparametric analysis and the improvement of mathematical analysis of FCM measurements ." ], "offsets": [ [ 0, 886 ] ] } ]
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[]
[]
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DerPathologe.70180027.eng.abstr
DerPathologe.70180027.eng.abstr
[ { "id": "DerPathologe.70180027.eng.abstr-passage-0", "type": "abstract", "text": [ "The frequency of biopsies with different types of mastitis among all patients with benign breast diseases in twenty years was 3 % . About 2/3 of the patients were younger than 50 years , the average age was 46,7 years . Comparing the frequency of the different types of mastitis the puerperal mastitis is very rare in contrast to the increasing non-puerperal and granulomatous inflammatory breast lesions . The diagnosis \" granulomatous mastitis \" is one of exclusion . Both non-infectious and infectious causes must be considered . The origin of the granulomatous mastitis often is unknown , but it is supposed to be an autoimmune localized response due to the retained and extravasated fat and protein rich secretions in the ducts in cases of hyperprolactinemia ( drug induced or by microprolactinomas ) or hormonal imbalances characterized by epitheloid cell granulomas with giant cells microabscesses around lipid drops , but without necroses . An idiopathic type of granulomatous mastitis concerns young women in relationship to parturition with a similar histological pattern predominantly of the lobules . Special types of mastitis are the B-lymphocytic autoimmune mastitis associated with a longstanding insulindependent diabetes mellitus type I , the sarcoidosis , panniculitis and the rare but very different infectious diseases with breast involvement . Particularily in cases without features of secretory activity a carefully bacterioscopic and microbiologic workup of fresh material from the surgical specimes is necessary for a final diagnostic report ." ], "offsets": [ [ 0, 1568 ] ] } ]
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"DerPathologe.70180027.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "mastitis" ], "offsets": [ [ 270, 278 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024894" } ] }, { "id": "DerPathologe.70180027.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "puerperal" ], "offsets": [ [ 283, 292 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086839" } ] }, { "id": "DerPathologe.70180027.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "mastitis" ], "offsets": [ [ 293, 301 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024894" } ] }, { "id": "DerPathologe.70180027.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "contrast" ], "offsets": [ [ 318, 326 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0110625" } ] }, { "id": "DerPathologe.70180027.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "non-puerperal" ], "offsets": [ [ 345, 358 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086839" } ] }, { "id": "DerPathologe.70180027.eng.abstr-s3-t7", "type": "umlsterm", 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DerPathologe.70180037.eng.abstr
DerPathologe.70180037.eng.abstr
[ { "id": "DerPathologe.70180037.eng.abstr-passage-0", "type": "abstract", "text": [ "Invasive lobular carcinoma ( ILC ) is recognized in its classical form and as variants with tubulo-lobular , solid , pleomorphic , alveolar or signet ring cell differentiation . The most common classical form differs from invasive ductal carcinoma ( IDC ) by its slower tumor proliferation and less common axillary metastases . When compared stage by stage , long term prognosis is similar to IDC , however . Prognostic subtyping of ILC can be achieved by the recognition of variant forms and mitotic counting . The combination of these factors may be used for tumor grading ( 5-year survival 100 % with grade 1 vs. 82 % with grade 2 , and 57 % with grade 3 , n = 241 ) . The detailled histopatholgic diagnosis therefore permits prognostic assesment also in ILC ." ], "offsets": [ [ 0, 763 ] ] } ]
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[]
[]
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DerPathologe.70180045.eng.abstr
DerPathologe.70180045.eng.abstr
[ { "id": "DerPathologe.70180045.eng.abstr-passage-0", "type": "abstract", "text": [ "Breast cancer is the most frequent malignant tumor in women , whereas it is rare in men . In our own case series the ratio is 175 : 1. The present paper deals with an evaluation of clinical and morphological findings from a series of 54 de novo male breast cancers observed in our institution from 1978 to 1996 and a comparative discussion of 528 female breast cancers from the same geographic area . We should like to focus on the following observations :" ], "offsets": [ [ 0, 456 ] ] } ]
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[]
[]
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DerPathologe.70180053.eng.abstr
DerPathologe.70180053.eng.abstr
[ { "id": "DerPathologe.70180053.eng.abstr-passage-0", "type": "abstract", "text": [ "The long-term disease free survival in patients treated by breast conserving therapy is similar to that of patients treated by mastectomy . In breast conserving therapie there is a significant risk of local recurrence . Although local recurrence does not appear to effect survival , there is certainly associated morbidity and attendant emotional trauma . Microscopic evaluation of the margins of lumpectomy specimens is the only way to define the extent of the tumour and the adequacy of resection ." ], "offsets": [ [ 0, 500 ] ] } ]
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[]
[]
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DerPathologe.70180060.eng.abstr
DerPathologe.70180060.eng.abstr
[ { "id": "DerPathologe.70180060.eng.abstr-passage-0", "type": "abstract", "text": [ "In a regional quality assurance project for screening mammography ( German Mammography Study ) , 27 335 women were screened in 40 participating , office-based mammography units from 1990-1992 . Screening led to 317 biopsies with a positive predictive value of 0.33. All biopsy documentation available to the mammography physicians was analysed with a view towards biopsy interval and completeness of information fed back to the Mx physicians . Biopsy recommendations were acted upon in 29 % of cases within 2 weeks . With the exception of the dignity Mx physicians were incompletely informed about biopsy results . The surgical procedure was known in the doctors ' offices in 62 % of the cases . Specimen radiographies were not done regularly . A pathology report was available overall in 42 of 106 malignant cases , respectively . With the exception of the histological diagnosis itself , no variable mentioned in the reports was documented completely . Only one third of the physicians received such reports routinely . Fail-safe information are requested by Mx physicians and can help them to better target biopsy recommendations . A ( regional ) quality assurance center should be made responsible to analyse the flow of information in mammography screening , to fill in gaps and to speed up professional cooperation ." ], "offsets": [ [ 0, 1322 ] ] } ]
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DerPathologe.70180124.eng.abstr
DerPathologe.70180124.eng.abstr
[ { "id": "DerPathologe.70180124.eng.abstr-passage-0", "type": "abstract", "text": [ "The frequency and prognostic relevance of sarcoid-likelesions and microcarcinosis in regional lymph nodes in gastric cancer ( n = 113 ; pT1-3, pN0-1, pM0, R0) were investigated ; the prognostic value was compared with pT and pN stage , grading and Laurén's tumor classification with Cox's multivariate regression-model . Sarcoid like lesions were found in 34 % of the cases ( n = 113 ) . Statistical analysis did not indicate that they had any prognostic value or showed whether or not microcarcinosis or metastasis was present ; they were independent of pT stage , histological tumor type , tumor grading , and the clinical course of disease . Microcarcinosis ( defined as scattered carcinoma cells within lymph node sinuses or pulp without adjacent stromal reaction ) was revealed by immunohistochemistry in 90 % of pN0 cases ; the presence of 3 or more tumor cells per lymph node section in over 10 % of sampled lymph nodes per case carried a significant prognostic value . In microcarcinosis without evidence of metastasis , the number of tumor cells and the number of involved lymph nodes are of prognostic value . In pN1 cases microcarcinosis was found as well as the metastases in 97 % and had no additional prognostic value . Microcarcinosis alone has a different significance from lymph node metastasis for prognosis ." ], "offsets": [ [ 0, 1327 ] ] } ]
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[]
[]
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DerPathologe.70180131.eng.abstr
DerPathologe.70180131.eng.abstr
[ { "id": "DerPathologe.70180131.eng.abstr-passage-0", "type": "abstract", "text": [ "In the scope of a multi-center-study 35 resection specimens from patients with locally advanced non-small cell lung cancer after neoadjuvant chemotherapy and radiation were processed histologically and graded according to the following regression grading system : grade I : no or only slight , in general spontaneous tumor regression , grade II a : incomplete tumor regression with more than 10 % and grade II b less than 10 % vital tumor tissue as well as grade III : complete tumor regression . In 15 patients with grade II a to III tumor regression roughly concentric foci of various size with a sequence of central tumor necrosis , narrow foam cell rim , vascular granulation tissue and peripheral scar formation were demonstrated as characteristic feature of response to neoadjuvant therapy . In patients with grade II b to III tumor regression ( \" responders \" ) median survival time of 27.9 months was significantly longer than in patients with grade I to II a tumor regression ( \" non-responders \" ) with a median survival time of 12.7 months ." ], "offsets": [ [ 0, 1052 ] ] } ]
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DerPathologe.70180141.eng.abstr
DerPathologe.70180141.eng.abstr
[ { "id": "DerPathologe.70180141.eng.abstr-passage-0", "type": "abstract", "text": [ "Multiple intra- and paraglandular lymph nodes develop in the parotid gland , including salivary gland tissue with acinar and ductal formations . In the same way heterotopic salivary gland tissue can be localized in cervical lymph nodes . Except for the frequently occurring Warthin tumours , primary salivary gland tumours , which develop in the lymph nodes of the parotid gland or the cervical lymph nodes , are rare . Examples of these are adenomas ( pleomorphic adenoma , basal cell adenoma ) and carcinomas ( acinic cell carcinoma , mucoepidermoid carcinoma , sebaceous gland carcinoma ) . Three of our own observations ( sebaceous lymphadenoma , acinic cell carcinoma , mucoepidermoid carcinoma ) are analysed . The condition for the diagnosis of primary salivary gland tumour within a lymph node is reliable evidence that the salivary gland tissue is tumour-free and that no other occult carcinoma is present ." ], "offsets": [ [ 0, 916 ] ] } ]
[ { "id": "DerPathologe.70180141.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "paraglandular" ], "offsets": [ [ 20, 33 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030563" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "lymph" ], "offsets": [ [ 34, 39 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024202" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "parotid" ], "offsets": [ [ 61, 68 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030580" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "tissue" ], "offsets": [ [ 102, 108 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040300" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "lymph nodes" ], "offsets": [ [ 34, 45 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024204" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "parotid gland" ], "offsets": [ [ 61, 74 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030580" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "salivary gland" ], "offsets": [ [ 87, 101 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036098" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "tissue" ], "offsets": [ [ 188, 194 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040300" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "lymph" ], "offsets": [ [ 224, 229 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024202" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "salivary gland" ], "offsets": [ [ 173, 187 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036098" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "lymph nodes" ], "offsets": [ [ 224, 235 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024204" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "Warthin" ], "offsets": [ [ 274, 281 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043037" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "tumours" ], "offsets": [ [ 282, 289 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "tumours" ], "offsets": [ [ 315, 322 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "lymph" ], "offsets": [ [ 346, 351 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024202" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "parotid" ], "offsets": [ [ 365, 372 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030580" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "lymph" ], "offsets": [ [ 395, 400 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024202" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s3-t7", "type": "umlsterm", "text": [ "salivary gland" ], "offsets": [ [ 300, 314 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036098" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s3-t8", "type": "umlsterm", "text": [ "lymph nodes" ], "offsets": [ [ 346, 357 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024204" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s3-t9", "type": "umlsterm", "text": [ "parotid gland" ], "offsets": [ [ 365, 378 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030580" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s3-t10", "type": "umlsterm", "text": [ "lymph nodes" ], "offsets": [ [ 395, 406 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024204" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "adenomas" ], "offsets": [ [ 442, 450 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001430" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "adenoma" ], "offsets": [ [ 465, 472 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001430" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "cell" ], "offsets": [ [ 481, 485 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "adenoma" ], "offsets": [ [ 486, 493 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001430" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "carcinomas" ], "offsets": [ [ 500, 510 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007097" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s4-t6", "type": "umlsterm", "text": [ "cell" ], "offsets": [ [ 520, 524 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s4-t7", "type": "umlsterm", "text": [ "carcinoma" ], "offsets": [ [ 525, 534 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007097" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s4-t8", "type": "umlsterm", "text": [ "carcinoma" ], "offsets": [ [ 552, 561 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007097" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s4-t9", "type": "umlsterm", "text": [ "carcinoma" ], "offsets": [ [ 580, 589 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007097" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s4-t10", "type": "umlsterm", "text": [ "pleomorphic adenoma" ], "offsets": [ [ 453, 472 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026277" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s4-t11", "type": "umlsterm", "text": [ "mucoepidermoid carcinoma" ], "offsets": [ [ 537, 561 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0206694" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s4-t12", "type": "umlsterm", "text": [ "sebaceous gland" ], "offsets": [ [ 564, 579 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036505" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s4-t13", "type": "umlsterm", "text": [ "basal cell adenoma" ], "offsets": [ [ 475, 493 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0205646" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "observations" ], "offsets": [ [ 611, 623 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0302523" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "cell" ], "offsets": [ [ 658, 662 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "carcinoma" ], "offsets": [ [ 663, 672 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007097" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "carcinoma" ], "offsets": [ [ 690, 699 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007097" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s5-t5", "type": "umlsterm", "text": [ "mucoepidermoid carcinoma" ], "offsets": [ [ 675, 699 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0206694" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "diagnosis" ], "offsets": [ [ 739, 748 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011900" }, { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "tumour" ], "offsets": [ [ 775, 781 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "lymph" ], "offsets": [ [ 791, 796 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024202" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "tissue" ], "offsets": [ [ 847, 853 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040300" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s6-t5", "type": "umlsterm", "text": [ "tumour-free" ], "offsets": [ [ 857, 868 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s6-t6", "type": "umlsterm", "text": [ "carcinoma" ], "offsets": [ [ 894, 903 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007097" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s6-t7", "type": "umlsterm", "text": [ "salivary gland" ], "offsets": [ [ 760, 774 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036098" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s6-t8", "type": "umlsterm", "text": [ "lymph node" ], "offsets": [ [ 791, 801 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024204" } ] }, { "id": "DerPathologe.70180141.eng.abstr-s6-t9", "type": "umlsterm", "text": [ "salivary gland" ], "offsets": [ [ 832, 846 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036098" } ] } ]
[]
[]
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DerPathologe.70180147.eng.abstr
DerPathologe.70180147.eng.abstr
[ { "id": "DerPathologe.70180147.eng.abstr-passage-0", "type": "abstract", "text": [ "Having observed 2 cases of lymphoepithelioma-like carcinoma of the lung in a 49-year-old female and in a 66-year-old male patient , we present a review on this entity , which was described for the first time in 1987. Essentially this neoplasm has the same histological appearance as a Schmincke-Regaud tumor , but it is possible that a certain morphological variety exists . In the differential diagnosis , a metastasis of a Schmincke-Regaud tumor and a malignant lymphoma should be considered . Including our 2 cases , a total of 30 cases have been reported : 14 male patients aged between 33 and 73 years and 12 female patients between 38 and 70 years ; in 4 cases there was no reference to sex or age . Most of the patients were Asians , mainly Chinese . These tumors presented with nearly the same frequency in both lungs . They mostly appeared as peripheral coin lesions in the chest X-ray study . Lymph node metastases were found in approximately 25 % of the cases . Hematogenous metastases seldom occurred and were observed almost only in the skeletal system . In most cases a lobectomy was performed . At present , no exact assertion is possible regarding the prognosis . An association with an Epstein-Barr virus infection was observed in the Asian patients , but not in the Caucasian patients ." ], "offsets": [ [ 0, 1304 ] ] } ]
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DerPathologe.70180160.eng.abstr
DerPathologe.70180160.eng.abstr
[ { "id": "DerPathologe.70180160.eng.abstr-passage-0", "type": "abstract", "text": [ "Adipose tissue tumors are often characterized by typical or even specific chromosomal alterations . In some of the cases the molecular background of these microscopically visible alterations was already elucidated . In myxoid liposarcomas the translocation t ( 12 ; 16 ) creates a fusion gene between the CHOP gene and the FUS gene and in lipomas the HMGI-C gene becomes rearrranged by structural aberrations involving chromosomal region 12q14-15. Based on examples of a lipoma , a well-differentiated liposarcoma , a myxoid liposarcoma , and an aggressive angiomyxoma it is demonstrated in the present paper how cytogenetic investigation can be used as an additional tool for an improved diagnosis of adipose tissue tumors . Furthermore , the detection of molecular mechanisms underlying the visible cytogenetic alterations will certainly significantly increase our knowledge about the pathogenesis of these diseases ." ], "offsets": [ [ 0, 919 ] ] } ]
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DerPathologe.70180167.eng.abstr
DerPathologe.70180167.eng.abstr
[ { "id": "DerPathologe.70180167.eng.abstr-passage-0", "type": "abstract", "text": [ "Progressive dyspnoea developed in a 37-year-old woman over a period of 2 months . A chest x-ray and echocardiography revealed a massive dilatation of the heart with thrombi in both ventricles . The endomyocardial biopsy was classified as myocarditis in two different departments of pathology . The patient developed thromboembolic events and an untreatable heart failure which led to the patient's death . The necropsy revealed a dilated 600-gram-heart and thrombi in both ventricles . On histological and immunhistological examination of the heart , the original diagnosis was corrected to catecholamine-induced dilated cardiomyopathy ." ], "offsets": [ [ 0, 637 ] ] } ]
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[]
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DerPathologe.70180207.eng.abstr
DerPathologe.70180207.eng.abstr
[ { "id": "DerPathologe.70180207.eng.abstr-passage-0", "type": "abstract", "text": [ "Since the first description of cytomegaly as \" disease with protozoan-like cells \" more than 50 years have past until a definitive explanation of the viral aetiology was reached . In the eighties cytomegaly gained increasing importance in adults . This event was based upon the occurrence of cytomegaly especially in patients with organ transplantation , AIDS infection , chronic dialysis or chemotherapy of malignant tumours . With the development of immunohistochemistry ( IHC ) , in situ hybridization ( IHS ) and polymerase chain reaction ( PCR ) new , more sensitive methods became available to detect CMV infections especially in biopsy specimens or cytological material . With IHC , ISH and PCR CMV verification is possible in seemingly normal cells without inclusion bodies . PCR can be used also on small biopsy particles of paraffin-embedded material and is characterized by high specifity and sensitivity . The parallel performance of IHC and ISH was proved to be useful in routine diagnostic work , whereas PCR should be used especially in diagnostically different cases . The methods of the evidence of CMV infection are analysed in the different organs ." ], "offsets": [ [ 0, 1168 ] ] } ]
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DerPathologe.70180218.eng.abstr
DerPathologe.70180218.eng.abstr
[ { "id": "DerPathologe.70180218.eng.abstr-passage-0", "type": "abstract", "text": [ "Atherosclerosis and its complications determine the majority of deaths in the western world , followed by malignant tumors . The present work introduces a classification of stages of atherosclerotic disease based on relevant pathogenic and therapeutic concepts , elaborated by H. Stary . At the present , we are able to relate different lesion types to a time course and partly to interferences between participating cell populations as well as to special pathogenic stimuli . From the therapeutic view , this knowledge is fundamental for preventive as well as interventional strategies like gene therapy . Distinct atherosclerotic plaques reveal a different composition and architecture , which may account for the variable risk for further complications of lesions showing the same size and degree of stenosis . In combination with an advanced clinical and diagnostic characterization of atherosclerotic lesions , the present concept might contribute to a better and differential therapy of atherosclerosis ." ], "offsets": [ [ 0, 1010 ] ] } ]
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[]
[]
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DerPathologe.70180233.eng.abstr
DerPathologe.70180233.eng.abstr
[ { "id": "DerPathologe.70180233.eng.abstr-passage-0", "type": "abstract", "text": [ "Nonepithelial malignant tumors of the pancreas are extremely rare neoplasms with a frequency of ~0 , 6% . They are always explored because of a suspected diagnosis of pancreatic carcinoma . Amongst the more than 600 primary pancreatic neoplasms in our pancreatic tumor archive only 5 neoplasms were of nonepithelial origin ( one was a malignant peripheral nerve sheath tumor [ MPNST ] , one a leiomyosarcoma , one a malignant mesothelioma , and two were peripheral neuroectodermal tumors [ PNET ] . The differential diagnosis includes secondary infiltration of the pancreas by mesenchymal tumors of the retroperitoneum , undifferentiated pancreatic carcinoma and , especially in the case of PNET , malignant lymphoma . Preoperative chemotherapy and down-staging can improve the operability and prognosis , especially in PNET ." ], "offsets": [ [ 0, 826 ] ] } ]
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"C0376249" } ] }, { "id": "DerPathologe.70180233.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "malignant tumors" ], "offsets": [ [ 14, 30 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006826" } ] }, { "id": "DerPathologe.70180233.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "diagnosis" ], "offsets": [ [ 154, 163 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011900" }, { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerPathologe.70180233.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "pancreatic" ], "offsets": [ [ 167, 177 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0070016" } ] }, { "id": "DerPathologe.70180233.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "carcinoma" ], "offsets": [ [ 178, 187 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007097" } ] }, { "id": "DerPathologe.70180233.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "pancreatic" ], "offsets": [ [ 224, 234 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0070016" } ] }, { "id": "DerPathologe.70180233.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "neoplasms" ], "offsets": [ [ 235, 244 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" }, { "db_name": "UMLS", "db_id": "C0036210" } ] }, { "id": "DerPathologe.70180233.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "pancreatic" ], "offsets": [ [ 252, 262 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0070016" } ] }, { "id": "DerPathologe.70180233.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "tumor" ], "offsets": [ [ 263, 268 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.70180233.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "archive" ], "offsets": [ [ 269, 276 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003738" } ] }, { "id": "DerPathologe.70180233.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "neoplasms" ], "offsets": [ [ 284, 293 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" }, { "db_name": "UMLS", "db_id": "C0036210" } ] }, { "id": "DerPathologe.70180233.eng.abstr-s3-t7", "type": "umlsterm", "text": [ "origin" ], "offsets": [ [ 316, 322 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0079946" } ] }, { "id": "DerPathologe.70180233.eng.abstr-s3-t8", "type": "umlsterm", "text": [ "malignant" ], "offsets": [ [ 335, 344 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006826" } ] }, { "id": "DerPathologe.70180233.eng.abstr-s3-t9", "type": "umlsterm", "text": [ "nerve" ], "offsets": [ [ 356, 361 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027769" } ] }, { "id": "DerPathologe.70180233.eng.abstr-s3-t10", "type": "umlsterm", "text": [ "tumor" ], "offsets": [ [ 369, 374 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.70180233.eng.abstr-s3-t11", "type": "umlsterm", "text": [ "MPNST" ], "offsets": [ [ 377, 382 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0206727" } ] }, { "id": "DerPathologe.70180233.eng.abstr-s3-t12", "type": "umlsterm", "text": [ "leiomyosarcoma" ], "offsets": [ [ 393, 407 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023269" } ] }, { "id": "DerPathologe.70180233.eng.abstr-s3-t13", "type": "umlsterm", "text": [ "malignant" ], "offsets": [ [ 416, 425 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006826" } ] }, { "id": "DerPathologe.70180233.eng.abstr-s3-t14", "type": "umlsterm", "text": [ "mesothelioma" ], "offsets": [ [ 426, 438 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025500" } ] }, { "id": "DerPathologe.70180233.eng.abstr-s3-t15", "type": "umlsterm", "text": [ "tumors" ], "offsets": [ [ 481, 487 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.70180233.eng.abstr-s3-t16", "type": "umlsterm", "text": [ "PNET" ], "offsets": [ [ 490, 494 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0206663" }, { "db_name": "UMLS", "db_id": "C0684337" } ] }, { "id": "DerPathologe.70180233.eng.abstr-s3-t17", "type": "umlsterm", "text": [ "pancreatic neoplasms" ], "offsets": [ [ 224, 244 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030297" } ] }, { "id": "DerPathologe.70180233.eng.abstr-s3-t18", "type": "umlsterm", "text": [ "peripheral nerve" ], "offsets": [ [ 345, 361 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031119" } ] }, { "id": "DerPathologe.70180233.eng.abstr-s3-t19", "type": "umlsterm", "text": [ "neuroectodermal tumors" ], "offsets": [ [ 465, 487 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0206093" } ] }, { "id": "DerPathologe.70180233.eng.abstr-s3-t20", "type": "umlsterm", "text": [ "nerve sheath tumor" ], "offsets": [ [ 356, 374 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0206727" } ] }, { "id": "DerPathologe.70180233.eng.abstr-s3-t21", "type": "umlsterm", "text": [ "peripheral neuroectodermal tumors" ], "offsets": [ [ 454, 487 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0684337" } ] }, { "id": "DerPathologe.70180233.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "diagnosis" ], "offsets": [ [ 516, 525 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011900" }, { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerPathologe.70180233.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "secondary" ], "offsets": [ [ 535, 544 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027627" }, { "db_name": "UMLS", "db_id": "C0036525" } ] }, { "id": "DerPathologe.70180233.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "pancreas" ], "offsets": [ [ 565, 573 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0346647" }, { "db_name": "UMLS", "db_id": "C0030274" } ] }, { "id": "DerPathologe.70180233.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "tumors" ], "offsets": [ [ 589, 595 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.70180233.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "retroperitoneum" ], "offsets": [ [ 603, 618 ] ], "normalized": [ { "db_name": "UMLS", 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{ "db_name": "UMLS", "db_id": "C0206663" }, { "db_name": "UMLS", "db_id": "C0684337" } ] } ]
[]
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DerPathologe.70180243.eng.abstr
DerPathologe.70180243.eng.abstr
[ { "id": "DerPathologe.70180243.eng.abstr-passage-0", "type": "abstract", "text": [ "Capillary hemangiomas occur rather ubiquitously , but extremely rare within the wall of blood vessels . For this reason the authors report on a small capillary hemangioma of sinusoidal type . It has been observed fortuitously within the wall of the portal vein at autopsy of a 79-year-old woman . Based on site and structural characteristics the benign neoplasia is supposed to have developed from a local malformation , probably an abortive liver anlage ." ], "offsets": [ [ 0, 456 ] ] } ]
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[]
[]
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DerPathologe.70180246.eng.abstr
DerPathologe.70180246.eng.abstr
[ { "id": "DerPathologe.70180246.eng.abstr-passage-0", "type": "abstract", "text": [ "We report on unusual presentation forms of Pneumocystis carinii infection of the lung in two patients with AIDS . A 36-years-old woman presented a cavitation in the lung middle lobe and bullous changes in the apical portion of the right upper lobe on the chest x-ray . The biopsy of these lesions was not diagnostic and the patient was operated on . The surgical specimen of the removed lung segment showed a cavitary lesion with a border of granulation tissue with giant cells , focal recent and older hemorrhages , rests of fibrinous exudate and dystrophic calcifications . In the surrounding tissue there were Pneumocystis carinii in the alveolar spaces and also in the alveolar walls , this tissue invasion through the organisms being most probably the cause of the cavitary change . A cytomegalic virus infection was also found ." ], "offsets": [ [ 0, 834 ] ] } ]
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[]
[]
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DerPathologe.70180252.eng.abstr
DerPathologe.70180252.eng.abstr
[ { "id": "DerPathologe.70180252.eng.abstr-passage-0", "type": "abstract", "text": [ "The case of a 63-year-old man with a widespread retroperitoneal tumor and two tumor nodules in the left testis is described . Histopathological and cytopathological examination of tissue from the retroperitoneal tumor led to a diagnosis of lymphoreticular neoplasia . The patient died in acute cardiac failure , five weeks after initial presentation . Autopsy revealed another tumor nodule in the right atrium . Macroscopically , the bone marrow appeared normal . The tumor cells were reactive for CD45, vimentin and chloroacetate esterase , but were unreactive with a broad spectrum of antibodies against myelomonocytic and lymphocytic antigens and antibodies against tryptase and c-kit ( CD117), characteristic markers for mast cells . However , the bone marrow exhibited the typical picture of mastocytosis . A diagnosis of bone marrow mastocytosis with an associated secondary extramedullary mast cell sarcoma was established . The cause of death was heart failure due to arrhythmia caused by an exophytic atrioseptal tumor nodule ." ], "offsets": [ [ 0, 1036 ] ] } ]
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"normalized": [ { "db_name": "UMLS", "db_id": "C0243140" } ] }, { "id": "DerPathologe.70180252.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "tissue" ], "offsets": [ [ 180, 186 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040300" } ] }, { "id": "DerPathologe.70180252.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "tumor" ], "offsets": [ [ 212, 217 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.70180252.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "diagnosis" ], "offsets": [ [ 227, 236 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011900" }, { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerPathologe.70180252.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "neoplasia" ], "offsets": [ [ 256, 265 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.70180252.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 272, 279 ] ], "normalized": [ { "db_name": 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"text": [ "cells" ], "offsets": [ [ 474, 479 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "DerPathologe.70180252.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "vimentin" ], "offsets": [ [ 504, 512 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042666" } ] }, { "id": "DerPathologe.70180252.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "chloroacetate" ], "offsets": [ [ 517, 530 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0109398" } ] }, { "id": "DerPathologe.70180252.eng.abstr-s6-t5", "type": "umlsterm", "text": [ "esterase" ], "offsets": [ [ 531, 539 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014894" } ] }, { "id": "DerPathologe.70180252.eng.abstr-s6-t6", "type": "umlsterm", "text": [ "antibodies" ], "offsets": [ [ 587, 597 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003241" } ] }, { "id": "DerPathologe.70180252.eng.abstr-s6-t7", "type": "umlsterm", "text": [ "antigens" ], "offsets": [ [ 637, 645 ] ], "normalized": 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"DerPathologe.70180252.eng.abstr-s6-t13", "type": "umlsterm", "text": [ "chloroacetate esterase" ], "offsets": [ [ 517, 539 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0055384" } ] }, { "id": "DerPathologe.70180252.eng.abstr-s6-t14", "type": "umlsterm", "text": [ "mast cells" ], "offsets": [ [ 725, 735 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024880" } ] }, { "id": "DerPathologe.70180252.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "bone" ], "offsets": [ [ 752, 756 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0262950" } ] }, { "id": "DerPathologe.70180252.eng.abstr-s7-t2", "type": "umlsterm", "text": [ "marrow" ], "offsets": [ [ 757, 763 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376152" } ] }, { "id": "DerPathologe.70180252.eng.abstr-s7-t3", "type": "umlsterm", "text": [ "mastocytosis" ], "offsets": [ [ 797, 809 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024899" } ] }, { "id": "DerPathologe.70180252.eng.abstr-s7-t4", "type": 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"C0003811" } ] }, { "id": "DerPathologe.70180252.eng.abstr-s9-t5", "type": "umlsterm", "text": [ "tumor" ], "offsets": [ [ 1022, 1027 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerPathologe.70180252.eng.abstr-s9-t6", "type": "umlsterm", "text": [ "cause of death" ], "offsets": [ [ 936, 950 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007465" } ] } ]
[]
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DerPathologe.70180257.eng.abstr
DerPathologe.70180257.eng.abstr
[ { "id": "DerPathologe.70180257.eng.abstr-passage-0", "type": "abstract", "text": [ "A report is given of two patients with a history of splenectomy many years previously due to traumatic rupture . No vaccination was given to either patient . From a state of good health , both patients developed fulminant , therapy-resistant sepsis with proof of Streptococcus pneumoniae in the blood culture . Autopsy findings were similar to Waterhouse-Friderichsen- syndrome . In conjunction with the history of splenectomy , the final pathological diagnosis was a so- called OPSI syndrome . This postsplenectomy sepsis is discussed further ." ], "offsets": [ [ 0, 545 ] ] } ]
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[]
[]
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DerPathologe.70180275.eng.abstr
DerPathologe.70180275.eng.abstr
[ { "id": "DerPathologe.70180275.eng.abstr-passage-0", "type": "abstract", "text": [ "This review aims at describing the influence of established and not yet sufficiently characterized parameters on the prognosis of thyroid follicle cell carcinomas . The analysis of literature data covers a broad spectrum of pathologic and biologic factors from classical prognostic features like age , gender and tumor stage to mutation , activation or , where applicable , inactivation of tumor suppressor genes , metastasis-related genes and adhesion molecules ." ], "offsets": [ [ 0, 464 ] ] } ]
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[]
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DerPathologe.70180286.eng.abstr
DerPathologe.70180286.eng.abstr
[ { "id": "DerPathologe.70180286.eng.abstr-passage-0", "type": "abstract", "text": [ "Multiple endocrine neoplasia syndromes ( MEN ) encompass autosomal dominantly inherited diseases which are characterized by the syn- or metachrone development of neoplastic and hyperplastic neuroendocrine lesions in several glands of an affected patient . In MEN type 1 the parathyroids , endocrine pancreas and duodenum and the pituitary and in MEN type 2 the thyroid C-cells , adrenal medulla and parathyroids are involved . Due to the recent identification of the mu gene and RET protooncogene as MEN-1 and MEN-2, respectively , and the elucidation of the genetic defects in affected patients , direct mutational analysis of germline DNA allows for the unambiguous identification of gene carriers and therefore the discrimination of MEN-associated and sporadically occurring neuroendocrine tumors . This is especially helpful in the context of the fairly high de novo mutation rates in MEN , since the discrimination of familial and sporadic neuroendocrine lesions by conventional and immunohistochemical analyses is rather unreliable . While the development of neuroendocrine lesions in young patients , bilateral or multicentricer tumors and the combination of hyperplastic and neoplastic lesions are indicative for a MEN syndrome , such constellations may also occur coincidentally or in association with other inherited diseases . In this overview , most recent findings concerning pathogenesis , molecular features , clinics and therapeutic concepts of MEN-1 and 2 are summarized and discussed ." ], "offsets": [ [ 0, 1503 ] ] } ]
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DerPathologe.70180301.eng.abstr
DerPathologe.70180301.eng.abstr
[ { "id": "DerPathologe.70180301.eng.abstr-passage-0", "type": "abstract", "text": [ "Nodules in the thyroid are common . They may represent hyperplastic or adenomatous nodules , true adenomas or malignant neoplasms . The main task of the pathologist consists of the exclusion or demonstration of malignancy . This can be done preoperatively by fine needle aspiration ( FNA ) cytology , intraoperatively by frozen section diagnosis , and postoperatively by investigation of paraffin sections . The intention of this paper is to formulate guidelines for the diagnosis and differential diagnosis of thyroid nodules . The evaluation of thyroid nodules still depends on routine cytological or histological specimens since immunohistochemistry , flow-cytometry and molecular biological techniques sofar failed to provide significant aid in the process of distinguishing benign from malignant thyroid nodules ." ], "offsets": [ [ 0, 818 ] ] } ]
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[]
[]
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DerPathologe.70180328.eng.abstr
DerPathologe.70180328.eng.abstr
[ { "id": "DerPathologe.70180328.eng.abstr-passage-0", "type": "abstract", "text": [ "A 36-year-old man known as chronic alcohol abuser presently suffered from arthralgia and showed bilateral petriefied kidneys by sonography and computed tomography . Because of an unclear renal failure a kidney biopsy was performed and presented typical chronic renal oxalosis with massive oxalate crystal deposits , tubular atrophy and interstitital fibrosis . Since the man had never shown signs of hyperoxaluria in his life before , a secondary oxalosis was supposed . The subsequently prompted exploration established a three to four times abuse of rocket fuel with cola lemonade 12 years before during the patient's army time as a marine soldier . Such fuels contain ethylene glycol ( glysantin ) as antifreeze commonly known to cause in toxic doses acute renal tubular necrosis with hyperoxaluria . The presented case , however , suggests a rare sublethal ethylene glycol poisoning with initial renal tubular damage , oxalate crystal deposition and subsequent chronic interstitial oxalate nephritis with tubular atrophy , interstitial fibrosis and chronic renal failure . Undergoing chronic hemodialysis , the patient died 5 months after the kidney biopsy diagnosis by acute heart failure . At autopsy , progressed chronic renal oxalosis could be confirmed . Decompensated oxalate cardiomyopathy with disseminated myocardial oxalate crystal deposits caused acute heart failure promoted by myocardial hypertrophy in renal hypertension ." ], "offsets": [ [ 0, 1440 ] ] } ]
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