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DerPathologe.70180353.eng.abstr
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DerPathologe.70180353.eng.abstr
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"type": "abstract",
"text": [
"Meningiomas account for the most frequent primary intracranial neoplasms in adults . In 1993 , the so-called atypical meningioma has additionally been introduced in the revised edition of the WHO Classification of Tumors of the Central Nervous System and should characterize meningiomas with an increased propensity to recur . Since the given qualitative histological criteria apply both to the \" atypical \" and anaplastic meningioma , mere histological grading appears somewhat critical . Therefore , additional parameters were tested for their contribution to meningioma grading : First of all , we succeeded in defining 3 meningioma \" grades \" by calculating corresponding 95% confidence intervals for the morphometrically assessed Ki-67 indices of 160 meningiomas in total , the validity of which was proved by comparison with the \" recurrence \" -free intervals . Histologically , atypical meningiomas were distinguished by a \" syncytial \" , poorly structured growth pattern and macronucleoli . Only occasionally , nuclear pleomorphism , necroses and mitotic figures were found . Cytogenetics revealed , in 50% of the \" atypical \" and anaplastic meningiomas , partial loss of the short arm of one chromosome 1 ( 1p-). Histochemically , we could demonstrate , that the tissue non-specific type of alkaline phosphatase ( ALPL ) , which is coded on chromosome 1p , is a convenient recurrence- and progression-associated marker enzyme for meningiomas with 1p-loss ( loss of enzyme activity in 30/39 of intermediate and 8/8 anaplastic meningiomas ) . We favor to address the WHO \" atypical \" meningioma as meningioma of the intermediate type , since the attribute \" atypical \" in the context of histological diagnoses is highly susceptible to misinterpretations ."
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DerPathologe.70180368.eng.abstr
|
DerPathologe.70180368.eng.abstr
|
[
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"id": "DerPathologe.70180368.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Tumour-like lesions of the salivary glands are diseases which , in accordance with the new WHO classification of salivary gland tumours , can simulate a true tumour by swelling or induration of the salivary gland tissue . An additional rare entity , only recently not described in the new WHO classification , is \" sclerosing polycystic sialadenopathy \" ( s.p.s. ) which , especially in younger patients , results in nodular , incompletely encapsulated , tumour-like masses mainly of the parotid gland . Histologically , it is comparable to fibrocystic mastopathy and is characterized by distinct hyalinized , centrally accentuated sclerosing collageneous tissue with inclusion of cystically ectatic ducts and focal epithelial hyperplasia . In the hyperplastic ducts , transluminal bridges and cribriform patterns can develop , sometimes also apocrine secretion and eosinophilic globules . The s.p.s. must be distinguished mainly from cystadenoma , mucoepidermoid carcinoma and also from dysgenetic cystic parotid gland . Based on four of our own observations the differential diagnosis is analysed ."
],
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0,
1100
]
]
}
] |
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] |
DerPathologe.70180374.eng.abstr
|
DerPathologe.70180374.eng.abstr
|
[
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"id": "DerPathologe.70180374.eng.abstr-passage-0",
"type": "abstract",
"text": [
"TMLR ( Transmyocardial laser revascularization ) is a disputed cardiosurgical technique available in Europe since 1994 that aims to deliver additional blood flow to ischemic myocardium from the left heart chamber . Goal of our study is morphological examination of laser channels in human hearts to answer the questions : Are there patent laser channels with communication to the left chamber and to intramural vessels ? We examined hearts of 10 patients who died during the first 18 days after TMLR . Channels were examined in histological serial sections under the light microscope . Laser channels in the first days postoperatively have a lumen diameter of about 1 mm and are surrounded by coagulation necrosis about 500 µm thick . Despite phagocytic removal of necrotic tissue the lumen diameter decreases during the following two weeks . Open intramyocardial channels can be shown in all patients . These channels communicate with intramural vessels , but in no instance with chamber lumen . Our results suggest that clinical benefits are based on improved distribution of coronary blood . Additional blood is not delivered from left chamber lumen to the myocardium . However , our patients represent the small subgroup of the deceased . If similar observations can be made in the majority of patients living symptomfree after TMLR remains open ."
],
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0,
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]
]
}
] |
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"id": "DerPathologe.70180374.eng.abstr-s5-t2",
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] |
[] |
[] |
[
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DerPathologe.70180385.eng.abstr
|
DerPathologe.70180385.eng.abstr
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"id": "DerPathologe.70180385.eng.abstr-passage-0",
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],
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}
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[] |
[] |
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DerPathologe.70180390.eng.abstr
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DerPathologe.70180390.eng.abstr
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{
"id": "DerPathologe.70180390.eng.abstr-passage-0",
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"We report a locally recurrent retiform haemangioendothelioma ( RHE ) on the right great toe in a 40-year-old woman . There was a secondary soft tissue lesion on her right lower leg . Histologically , primary lesion , local recurrence and the secondary soft tissue lesion ( soft tissue metastasis ? ) showed identical features . Long , arborizing , neoplastic blood vessels were lined by CD31 and factor VIII-positive , monomorphic endothelial tumour cells ; focally solid tumour areas , papillae and a prominent inflammatory infiltrate consisting of mature B and T lymphocytes were noted . The concept and the group of low-grade malignant vascular neoplasms is discussed , with special emphasis on inclusion of RHE in this category ."
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DerPathologe.70180395.eng.abstr
|
DerPathologe.70180395.eng.abstr
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"id": "DerPathologe.70180395.eng.abstr-passage-0",
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"Malignant fibrous histiocytoma ( MFH ) , arising in combination with a sacral chordoma in a 70-year-old men , is described . Intermediate spindle-shaped cells demonstrating keratin positivity , showed a gradual transition between the areas of conventional chordoma , and the spindle cell areas , lending credence to the theory of a multipotential neoplasm . We chose the descriptive term \" chordoma with malignant spindle cell component \" in the sense that high malignant sarcomatous components exists in conjunction with chordomas in the primary tumor and the local recurrence . A review of literature is undertaken chronicling the documented associations of chordoma and sarcoma , followed by a discussion of the various causes proposed to explain this phenomenon ."
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0,
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[] |
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] |
DerPathologe.70180401.eng.abstr
|
DerPathologe.70180401.eng.abstr
|
[
{
"id": "DerPathologe.70180401.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A case of primary splenic angiosarcoma with involvement of two accessory spleens is presented . The tumor cells are immunoreactive for endothelial markers ( CD 31 , CD 34 , factor VIII associated antigen ) and express also histiocytic antigens ( CD 68 , lysozyme , Cathepsin D , alpha-1-antitrypsin, alpha-1-antichymotrypsin) as well as CD 8. This marker profile suggests that the presented angiosarcoma originates from sinus cells with histiocytic and endothelial differentiation and may be regarded as the malignant variant of littoral cells angioma ."
],
"offsets": [
[
0,
553
]
]
}
] |
[
{
"id": "DerPathologe.70180401.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"angiosarcoma"
],
"offsets": [
[
26,
38
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018923"
}
]
},
{
"id": "DerPathologe.70180401.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"spleens"
],
"offsets": [
[
73,
80
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0037993"
},
{
"db_name": "UMLS",
"db_id": "C0153470"
}
]
},
{
"id": "DerPathologe.70180401.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"tumor"
],
"offsets": [
[
100,
105
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027651"
}
]
},
{
"id": "DerPathologe.70180401.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"cells"
],
"offsets": [
[
106,
111
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0007634"
}
]
},
{
"id": "DerPathologe.70180401.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"markers"
],
"offsets": [
[
147,
154
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0005516"
}
]
},
{
"id": "DerPathologe.70180401.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"antigen"
],
"offsets": [
[
196,
203
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0003320"
}
]
},
{
"id": "DerPathologe.70180401.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"antigens"
],
"offsets": [
[
235,
243
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0003320"
}
]
},
{
"id": "DerPathologe.70180401.eng.abstr-s2-t6",
"type": "umlsterm",
"text": [
"lysozyme"
],
"offsets": [
[
254,
262
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0026794"
}
]
},
{
"id": "DerPathologe.70180401.eng.abstr-s2-t7",
"type": "umlsterm",
"text": [
"Cathepsin"
],
"offsets": [
[
265,
274
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0007428"
}
]
},
{
"id": "DerPathologe.70180401.eng.abstr-s2-t8",
"type": "umlsterm",
"text": [
"marker"
],
"offsets": [
[
348,
354
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0005516"
}
]
},
{
"id": "DerPathologe.70180401.eng.abstr-s2-t9",
"type": "umlsterm",
"text": [
"angiosarcoma"
],
"offsets": [
[
391,
403
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018923"
}
]
},
{
"id": "DerPathologe.70180401.eng.abstr-s2-t10",
"type": "umlsterm",
"text": [
"sinus"
],
"offsets": [
[
420,
425
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0030471"
}
]
},
{
"id": "DerPathologe.70180401.eng.abstr-s2-t11",
"type": "umlsterm",
"text": [
"cells"
],
"offsets": [
[
426,
431
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0007634"
}
]
},
{
"id": "DerPathologe.70180401.eng.abstr-s2-t12",
"type": "umlsterm",
"text": [
"malignant"
],
"offsets": [
[
508,
517
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0006826"
}
]
},
{
"id": "DerPathologe.70180401.eng.abstr-s2-t13",
"type": "umlsterm",
"text": [
"cells"
],
"offsets": [
[
538,
543
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0007634"
}
]
},
{
"id": "DerPathologe.70180401.eng.abstr-s2-t14",
"type": "umlsterm",
"text": [
"angioma"
],
"offsets": [
[
544,
551
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0018916"
}
]
},
{
"id": "DerPathologe.70180401.eng.abstr-s2-t15",
"type": "umlsterm",
"text": [
"factor VIII"
],
"offsets": [
[
173,
184
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0015506"
}
]
},
{
"id": "DerPathologe.70180401.eng.abstr-s2-t16",
"type": "umlsterm",
"text": [
"Cathepsin D"
],
"offsets": [
[
265,
276
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0007427"
}
]
}
] |
[] |
[] |
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{
"id": "DerPathologe.70180401.eng.abstr-s2-r101-t12.1-t1.1",
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},
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"id": "DerPathologe.70180401.eng.abstr-s2-r102-t16.1-t11.1",
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},
{
"id": "DerPathologe.70180401.eng.abstr-s2-r103-t5.1-t1.1",
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},
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"id": "DerPathologe.70180401.eng.abstr-s2-r104-t2.1-t5.1",
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},
{
"id": "DerPathologe.70180401.eng.abstr-s2-r105-t16.1-t7.1",
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},
{
"id": "DerPathologe.70180401.eng.abstr-s2-r106-t15.1-t9.1",
"type": "diagnoses",
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"arg2_id": "DerPathologe.70180401.eng.abstr-s2-t9",
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},
{
"id": "DerPathologe.70180401.eng.abstr-s2-r107-t11.1-t10.1",
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},
{
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},
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"id": "DerPathologe.70180401.eng.abstr-s2-r111-t7.1-t2.1",
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"id": "DerPathologe.70180401.eng.abstr-s2-r114-t11.1-t5.1",
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}
] |
DerPathologe.70180419.eng.abstr
|
DerPathologe.70180419.eng.abstr
|
[
{
"id": "DerPathologe.70180419.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Gangliocytomas or gangliogliomas of the sellar region are very rare tumors . In a great proportion of those cases an adenoma of the anterior pituitary develops from the cell type that is hyperstimulated by the releasing hormone produced from the gangliocytoma . Five GHRH secreting gangliocytomas are reported . Four of these were localized adjacent to a GH secreting adenoma . In one case , no adenoma tissue was found beside the ganglicytoma . As only the adenomas can secrete GH , the adenomas and not the gangliocytomas are directly responsible for acromegaly so that such an adenoma has to be present in cases of acromegaly . A CRH secreting gangliocytoma was combined with an ACTH cell adenoma that had induced Cushing's disease . A ganglioglioma of the posterior pituitary had led to an inappropriate secretion of Vasopressin . The morphology of the different tumors is presented ."
],
"offsets": [
[
0,
888
]
]
}
] |
[
{
"id": "DerPathologe.70180419.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"Gangliocytomas"
],
"offsets": [
[
0,
14
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0017075"
}
]
},
{
"id": "DerPathologe.70180419.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"gangliogliomas"
],
"offsets": [
[
18,
32
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0206716"
}
]
},
{
"id": "DerPathologe.70180419.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"tumors"
],
"offsets": [
[
68,
74
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027651"
}
]
},
{
"id": "DerPathologe.70180419.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"adenoma"
],
"offsets": [
[
117,
124
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0001430"
}
]
},
{
"id": "DerPathologe.70180419.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"anterior"
],
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[
132,
140
]
],
"normalized": [
{
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"db_id": "C0032008"
}
]
},
{
"id": "DerPathologe.70180419.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"pituitary"
],
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[
141,
150
]
],
"normalized": [
{
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"db_id": "C0032005"
}
]
},
{
"id": "DerPathologe.70180419.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"cell"
],
"offsets": [
[
169,
173
]
],
"normalized": [
{
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"db_id": "C0007634"
}
]
},
{
"id": "DerPathologe.70180419.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"hormone"
],
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[
220,
227
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0019932"
}
]
},
{
"id": "DerPathologe.70180419.eng.abstr-s2-t6",
"type": "umlsterm",
"text": [
"gangliocytoma"
],
"offsets": [
[
246,
259
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0017075"
}
]
},
{
"id": "DerPathologe.70180419.eng.abstr-s2-t7",
"type": "umlsterm",
"text": [
"the cell"
],
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[
165,
173
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0007634"
}
]
},
{
"id": "DerPathologe.70180419.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"GHRH"
],
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[
267,
271
]
],
"normalized": [
{
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"db_id": "C0037668"
}
]
},
{
"id": "DerPathologe.70180419.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"gangliocytomas"
],
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[
282,
296
]
],
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{
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"db_id": "C0017075"
}
]
},
{
"id": "DerPathologe.70180419.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"adenoma"
],
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[
368,
375
]
],
"normalized": [
{
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"db_id": "C0001430"
}
]
},
{
"id": "DerPathologe.70180419.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"adenoma"
],
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395,
402
]
],
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"db_id": "C0001430"
}
]
},
{
"id": "DerPathologe.70180419.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"tissue"
],
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[
403,
409
]
],
"normalized": [
{
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"db_id": "C0040300"
}
]
},
{
"id": "DerPathologe.70180419.eng.abstr-s6-t1",
"type": "umlsterm",
"text": [
"adenomas"
],
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458,
466
]
],
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{
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"db_id": "C0001430"
}
]
},
{
"id": "DerPathologe.70180419.eng.abstr-s6-t2",
"type": "umlsterm",
"text": [
"adenomas"
],
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[
488,
496
]
],
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}
]
},
{
"id": "DerPathologe.70180419.eng.abstr-s6-t3",
"type": "umlsterm",
"text": [
"gangliocytomas"
],
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509,
523
]
],
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"db_id": "C0017075"
}
]
},
{
"id": "DerPathologe.70180419.eng.abstr-s6-t4",
"type": "umlsterm",
"text": [
"acromegaly"
],
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[
553,
563
]
],
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{
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"db_id": "C0001206"
}
]
},
{
"id": "DerPathologe.70180419.eng.abstr-s6-t5",
"type": "umlsterm",
"text": [
"adenoma"
],
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]
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}
]
},
{
"id": "DerPathologe.70180419.eng.abstr-s6-t6",
"type": "umlsterm",
"text": [
"acromegaly"
],
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618,
628
]
],
"normalized": [
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"db_id": "C0001206"
}
]
},
{
"id": "DerPathologe.70180419.eng.abstr-s7-t1",
"type": "umlsterm",
"text": [
"CRH"
],
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[
633,
636
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0010132"
}
]
},
{
"id": "DerPathologe.70180419.eng.abstr-s7-t2",
"type": "umlsterm",
"text": [
"gangliocytoma"
],
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647,
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]
],
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}
]
},
{
"id": "DerPathologe.70180419.eng.abstr-s7-t3",
"type": "umlsterm",
"text": [
"ACTH"
],
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682,
686
]
],
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}
]
},
{
"id": "DerPathologe.70180419.eng.abstr-s7-t4",
"type": "umlsterm",
"text": [
"cell"
],
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687,
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]
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}
]
},
{
"id": "DerPathologe.70180419.eng.abstr-s7-t5",
"type": "umlsterm",
"text": [
"adenoma"
],
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]
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{
"id": "DerPathologe.70180419.eng.abstr-s7-t6",
"type": "umlsterm",
"text": [
"disease"
],
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}
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},
{
"id": "DerPathologe.70180419.eng.abstr-s8-t1",
"type": "umlsterm",
"text": [
"ganglioglioma"
],
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752
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],
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"db_id": "C0206716"
}
]
},
{
"id": "DerPathologe.70180419.eng.abstr-s8-t2",
"type": "umlsterm",
"text": [
"posterior"
],
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[
760,
769
]
],
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{
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"db_id": "C0032009"
}
]
},
{
"id": "DerPathologe.70180419.eng.abstr-s8-t3",
"type": "umlsterm",
"text": [
"pituitary"
],
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770,
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]
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"normalized": [
{
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"db_id": "C0032005"
}
]
},
{
"id": "DerPathologe.70180419.eng.abstr-s8-t4",
"type": "umlsterm",
"text": [
"secretion"
],
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808,
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]
],
"normalized": [
{
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"db_id": "C0036537"
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"db_id": "C0036536"
}
]
},
{
"id": "DerPathologe.70180419.eng.abstr-s8-t5",
"type": "umlsterm",
"text": [
"Vasopressin"
],
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[
821,
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]
],
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"db_id": "C0042413"
}
]
},
{
"id": "DerPathologe.70180419.eng.abstr-s8-t6",
"type": "umlsterm",
"text": [
"posterior pituitary"
],
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760,
779
]
],
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"db_id": "C0032009"
}
]
},
{
"id": "DerPathologe.70180419.eng.abstr-s9-t1",
"type": "umlsterm",
"text": [
"morphology"
],
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[
839,
849
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0543482"
}
]
},
{
"id": "DerPathologe.70180419.eng.abstr-s9-t2",
"type": "umlsterm",
"text": [
"tumors"
],
"offsets": [
[
867,
873
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027651"
}
]
}
] |
[] |
[] |
[
{
"id": "DerPathologe.70180419.eng.abstr-s2-r1-t2.1-t7.1",
"type": "adjacent_to",
"arg1_id": "DerPathologe.70180419.eng.abstr-s9-t2",
"arg2_id": "DerPathologe.70180419.eng.abstr-s2-t7",
"normalized": []
},
{
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"arg1_id": "DerPathologe.70180419.eng.abstr-s8-t5",
"arg2_id": "DerPathologe.70180419.eng.abstr-s8-t4",
"normalized": []
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{
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{
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{
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},
{
"id": "DerPathologe.70180419.eng.abstr-s2-r7-t4.1-t3.1",
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"arg2_id": "DerPathologe.70180419.eng.abstr-s8-t3",
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},
{
"id": "DerPathologe.70180419.eng.abstr-s2-r8-t5.1-t1.1",
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{
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},
{
"id": "DerPathologe.70180419.eng.abstr-s2-r10-t2.1-t6.1",
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},
{
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},
{
"id": "DerPathologe.70180419.eng.abstr-s2-r13-t1.1-t5.1",
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},
{
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"normalized": []
},
{
"id": "DerPathologe.70180419.eng.abstr-s2-r15-t4.1-t2.1",
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},
{
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] |
DerPathologe.70180425.eng.abstr
|
DerPathologe.70180425.eng.abstr
|
[
{
"id": "DerPathologe.70180425.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Complex mechanisms have evolved in mammalian cells for regulating cellular lifespan . Normal cells demonstrate a strictly limited growth potential and senescence after a defined number of cell divisions . In contrast , tumor cells often exhibit an apparently unlimited proliferation potential and are termed immortalized . It has been proposed that the progressive shortening of the tips of the eukaryotic chromosomes - the telomeres - is an important component of senescence and is involved in the control of cell cycle . The enzyme telomerase adds TTAGGG repeats onto mammalian telomeres , preventing their shortening . Telomerase is normally inactive in most somatic cells , but detectable in tumor cells . The activation of telomerase in malignant cancers seems to be an important step in tumorigenesis in order to gain the ability of indefinite proliferation and to become immortal . This review describes the present knowledge of telomeres and telomerase and their role in cellular senescence and human aging . It summarizes aspects of telomerase in cancer and its function as a diagnostic and prognostic tumor marker ."
],
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[
0,
1125
]
]
}
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] |
[] |
[] |
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DerPathologe.70180430.eng.abstr
|
DerPathologe.70180430.eng.abstr
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"id": "DerPathologe.70180430.eng.abstr-passage-0",
"type": "abstract",
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"Heterotopic tissue calcification represents a pathological event which goes along with active extra- and intracellular metabolic processes . The heterotopic calcification is not the manifestation of tissue ageing . Aetiologically , metastatic calcification , dystrophic calcification and genetic-hereditary calcification are distinguished . Two pathogenetic mechanisms play a role during the heterotopic calcification . The intracellular calcification is based upon the function of mitochondria as regulator of the calcium concentration and as \" lime-catcher \" . The extracellular calcification is initiated by membraneous organelles - so-called matrix vesicles . The further steps are the production of hydroxylapatite crystals which are eliminated from the matrix vesicles in the extracellular spaces . Special types of heterotopic calcification are hypercalcaemias ( tumour-associated hypercalcaemias , primary and tertiary hyperparathyroidism , drug-induced hypercalcaemias ) , tumoral calcinosis , intratumoral calcifications , calcifications of different organs ( lung , heart , vessels , joints , ligaments , skin or kidney ) . Some calcifications of organs show partly overlapping aetiological factors and pathogenetic mechanisms ."
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DerPathologe.70180445.eng.abstr
|
DerPathologe.70180445.eng.abstr
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"id": "DerPathologe.70180445.eng.abstr-passage-0",
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"Modern ultrasonic diagnostic instruments with high resolution and color Doppler sonography allow the obstetrician to describe pathological findings very precisely and at an early stage of pregnancy . The use of high-resolution ultrasound makes it possible to detect heart malformations already between the 8th and 10th week of gestation . This development has essentially changed the clinical requirements on fetal autopsy which in its traditional way no longer meets the increased demands . Unless the pathologists faces this challenge the importance of fetal autopsy will diminish . Modern image databases and communication techniques allow the pathologist to have direct access to text and images of pre-findings by other clinics . Great importance , however , must be attached to the interdisciplinary cooperation with obstetricians and geneticists . We report on routine fetal autopsy by using an interdisciplinary database an the Charité ."
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[] |
[] |
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DerPathologe.70180453.eng.abstr
|
DerPathologe.70180453.eng.abstr
|
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{
"id": "DerPathologe.70180453.eng.abstr-passage-0",
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"Description of a 27 years old patient with chronic renal failure due to diabetes , which requires dialysis , and tertiary hyperparathyroidism , who developed fulminant systemic calciphylaxis after successful renal transplantation . Characteristic of this syndrome , there occured soft tissue calcification , mediacalcinosis of the small and medium-sized arteries and ischemic skin necrosis . The pathogenesis is not completely clear , but challenging agents like corticosteroids or immunsuppressants , in a sensitized organism ( at hypercalcemia or elevated parathormon ) could lead to calcium deposits . These are showing a particular affinity for elastic tissue . Lungs , stomach , kidneys , cutis , heart and vascular system are most frequently involved . Treatment is primarily supportive ; an early parathyroidectomy seems to have the best prognosis ."
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DerPathologe.70180459.eng.abstr
|
DerPathologe.70180459.eng.abstr
|
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"id": "DerPathologe.70180459.eng.abstr-passage-0",
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"In this article we report on a 43-year-old man , who had been treated with two cortisone injections containing soja bean oil for epicondylitis humeri radialis . Four weeks after the second injection necrotized fat which had been extracted surgically was sent to us for histological examination . We could show a calcifying collagen fibre necrosis being cleared by a granulomatous reaction and resorbed by granulation tissue . The calcifying necrosis of collagen fibres might have been induced by soja bean oil which were used as carrier of the drug ."
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0,
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}
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[] |
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}
] |
DerPathologe.70180463.eng.abstr
|
DerPathologe.70180463.eng.abstr
|
[
{
"id": "DerPathologe.70180463.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report a rare case of psammocarcinoma which presented as a mass in the lower abdomen of an otherwise asymptomatic woman . Ultrasonographically , the tumor showed extensive calcification and was suspected to be a myoma . DNA image cytometry and assessment of proliferative activitity were performed and showed an euploid , low proliferating tumor cell population . This underlines the low malignancy of this type of carcinoma , which is comparable to that of serous borderline lesions of the ovary and explains the benign clinical course ."
],
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[
0,
541
]
]
}
] |
[
{
"id": "DerPathologe.70180463.eng.abstr-s1-t1",
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"abdomen"
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80,
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{
"id": "DerPathologe.70180463.eng.abstr-s1-t2",
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{
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152,
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},
{
"id": "DerPathologe.70180463.eng.abstr-s2-t2",
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175,
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}
]
},
{
"id": "DerPathologe.70180463.eng.abstr-s2-t3",
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215,
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},
{
"id": "DerPathologe.70180463.eng.abstr-s3-t2",
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"id": "DerPathologe.70180463.eng.abstr-s3-t3",
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"id": "DerPathologe.70180463.eng.abstr-s3-t4",
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}
]
},
{
"id": "DerPathologe.70180463.eng.abstr-s3-t5",
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354,
364
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}
]
},
{
"id": "DerPathologe.70180463.eng.abstr-s3-t6",
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{
"id": "DerPathologe.70180463.eng.abstr-s4-t3",
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"db_id": "C0029939"
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]
}
] |
[] |
[] |
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{
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},
{
"id": "DerPathologe.70180463.eng.abstr-s3-r12-t3.1-t6.1",
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"normalized": []
},
{
"id": "DerPathologe.70180463.eng.abstr-s3-r13-t4.1-t2.1",
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{
"id": "DerPathologe.70180463.eng.abstr-s3-r14-t6.1-t5.1",
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{
"id": "DerPathologe.70180463.eng.abstr-s3-r15-t2.1-t5.1",
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"normalized": []
},
{
"id": "DerPathologe.70180463.eng.abstr-s4-r1-t3.1-t1.1",
"type": "location_of",
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"arg2_id": "DerPathologe.70180463.eng.abstr-s4-t1",
"normalized": []
}
] |
DerPathologe.70180467.eng.abstr
|
DerPathologe.70180467.eng.abstr
|
[
{
"id": "DerPathologe.70180467.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report on a 36-year old male patient with clinically prolonged intermittent claudication of the right leg . An operative specimen measuring 8,0 cm of the A. poplitea was sent for examination , which was sheathed by an aneurysmal cyst having a maximal diameter of 1,5 cm . Examination under the light microscope showed an incomplete septated ganglion-like cystic formation with flat connective tissue-like cells or even larger histiocytoid cell elements as inner lining . Immunohistochemically , the cells on the inner lining of the cyst showed to be strongly positive to macrophage marker PG-M1, KP1 and Ki-Mp1. The endothelium of the vessels of the wall of the cyst showed a marked expression of cytokeratin 18. Immunohistochemically as well as in conventional histology , there are general parallels between cysts in cystic adventitial degeneration , ganglia and normal synovia as the two last mentioned tissues also show an expression of cytokeratin 18 at the endothelia of smaller vessels as well as an expression of macrophage-associated antigens on cells of the inner lining . Aetiopathologically , the cysts developing in the course of the disease are rather adventitial ganglia ."
],
"offsets": [
[
0,
1190
]
]
}
] |
[
{
"id": "DerPathologe.70180467.eng.abstr-s1-t1",
"type": "umlsterm",
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"old"
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{
"id": "DerPathologe.70180467.eng.abstr-s1-t2",
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"male"
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},
{
"id": "DerPathologe.70180467.eng.abstr-s1-t3",
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"db_id": "C0030705"
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{
"id": "DerPathologe.70180467.eng.abstr-s1-t4",
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{
"id": "DerPathologe.70180467.eng.abstr-s1-t5",
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"leg"
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105,
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"db_id": "C0023216"
}
]
},
{
"id": "DerPathologe.70180467.eng.abstr-s1-t6",
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"intermittent claudication"
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66,
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],
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"db_id": "C0021775"
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]
},
{
"id": "DerPathologe.70180467.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"cyst"
],
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232,
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"db_id": "C0010709"
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},
{
"id": "DerPathologe.70180467.eng.abstr-s3-t1",
"type": "umlsterm",
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"light"
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"db_id": "C0023693"
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]
},
{
"id": "DerPathologe.70180467.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"ganglion-like"
],
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344,
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],
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"db_id": "C0017067"
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}
]
},
{
"id": "DerPathologe.70180467.eng.abstr-s3-t3",
"type": "umlsterm",
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},
{
"id": "DerPathologe.70180467.eng.abstr-s3-t4",
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"cells"
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DerPathologe.70180480.eng.abstr
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DerPathologe.70180480.eng.abstr
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DerPathologe.70180484.eng.abstr
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DerPathologe.70180484.eng.abstr
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DerPathologe.70180488.eng.abstr
|
DerPathologe.70180488.eng.abstr
|
[
{
"id": "DerPathologe.70180488.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report on two patients , 74 and 73 years old , each of whom had had biopsy of the bronchial mucosa elsewhere . Histologically , normal mucosa and mild bronchitis was seen , respectively . In both patients a second biopsy specimen from the same site was taken , 4 and 7 days after the first biopsy . Now the diagnosis was carcinoma in situ ( not excluding early squamous carcinoma ) and squamous carcinoma , respectively . One of the patients came to our lung clinic for operation on the basis of the mentioned diagnosis . A third biopsy was performed for control purposes . It revealed just a perforation of a lymph node in the bronchial wall and some epithelioid granulomas without evidence of acid-fast bacilli . There was no evidence of malignancy in this specimen . Because of the discrepancy , the pathologist at the first institution was asked to send us the previous slides . On review of these slides , the described findings were seen , but they were interpreted as regenerative-atypical . In this way , an unnecessary surgical intervention was avoided . After a follow-up of 31/2 years the patient is healthy . In the other patient , because of the diagnosis of squamous carcinoma a lobectomy was undertaken by a surgeon elsewhere . The pathologist could not find any carcinoma in the surgical specimen . The biopsy material was reviewed in our department , the findings being interpreted as atypical , originating in reparative changes . Like the postoperative pathologist , we did not find any carcinoma in the surgical specimen . In both cases , therefore , regenerative-atypical changes after re-biopsy were first misinterpreted as a malignant process ."
],
"offsets": [
[
0,
1670
]
]
}
] |
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DerPathologe.7018s001.eng.abstr
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"The German Society of Pathology emerged from the Society of German Scientists and Physicians . Founded in Braunschweig in 1897 , the first scientific meeting was held in Duesseldorf in 1898. Rudolf Virchow was the first chairman up to this death in 1902. From the beginning the Society with its former name of German Pathological Society till the 2nd world war , was an association of German-speaking countries including Austrian and Swiss pathologists who also regularly presided at the meetings . Alternately the meetings were held in Germany , Austria , or Switzerland . The 100-year-history of the Society has been documented in 80 volumes of the meetings so far . Since 1903 these are published by Gustav Fischer , Jena-Stuttgart . The scientific results of the anual meetings show not only the growth and development of Pathology , but also the lectures and papers to the main subjects contribute considerably to the history of medical basic research in the 20th century . The chairmen's speeches combine to a history of problems in the subject of Pathology . Rudolf Virchow began it with his opening address in 1898. A special chapter covers the period of national socialism and German partition after the 2nd world war . The German Pathological Society suffered great losses by dismissal and emigration after 1933. Institutes rich in tradition got lost in East Germany . The partition of Germany , especially after construction of the wall , excluded the East German colleagues for Society life . An attempt has been made to record the losses in numbers by evaluation of the member lists of the meeting volumes . At the end of the century and after overcoming of the German partition , the German Society of Pathology has got a chance for revival ."
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DerPathologe.80190001.eng.abstr
|
DerPathologe.80190001.eng.abstr
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[
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"The scope of the present review is to define diagnostic criteria of benign prostatic lesions causing diagnostic difficulty in surgical pathology . The prostate harbors a variety of small acinar lesions that may mimic prostate cancer in biopsy specimens . Generally , the most important diagnostic clues are obtained on low-power magnification by assessing architectural features . Atypical adenomatous hyperplasia ( AAH ) is a small acinar proliferation closely related to hyperplastic glands . Diagnostic features of postatrophic hyperplasia include a lobular small acinar proliferation associated with atrophic and dilated acini . Basal cell hyperplasia and scleros-ing adenosis show characteristic stromal changes that are uncommon in prostate cancer . Additional cytological features and intraluminal secretions are also important in the diagnostic evaluation of small acinar lesions in biopsy specimens . Negative immunohistochemical results obtained with basal-cell-specific cytokeratins should be evaluated in context with other diagnostic criteria . The unequivocal demonstration of basal cells in small acinar lesions excludes invasive cancer . Other rare small acinar lesions must be recognized when assessing biopsy specimens , including verumontanum-mucosa hyperplasia , Cowper's glands and mesonephroid hyperplasia . The various small acinar lesions discussed in the present review have no clinical significance , except atypical adenomatous hyperplasia ( AAH ) , which may be a precursor of small acinar cancer of the transition zone . The biological and clinical significance of AAH , however , remains to be established ."
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DerPathologe.80190012.eng.abstr
|
DerPathologe.80190012.eng.abstr
|
[
{
"id": "DerPathologe.80190012.eng.abstr-passage-0",
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"text": [
"Enlargement of the prostate is an age-related , physiological process that is unique in human tissue . The prostate gland is the most common site of neoplastic disorders in men . Despite the growing impact of the various prostate diseases in terms of morbidity and mortality , the pathogenesis of benign prostate hyperplasia ( BPH ) and prostate cancer remains poorly understood . This reflects the complex composition of the gland with different anatomic , cellular and functional compartments that are differentially involved in benign and malignant disease processes . The present review summarizes new concepts on the morphogenesis of normal and abnormal growth in the human prostate . There is increasing evidence that prostatic stem cells are located in the basal cell layer that is basically involved in normal growth and the development of glandular hyperplasia and prostate cancer . High-grade prostatic intraepithelial neoplasia is considered the most likely precursor of clinically important cancer of the peripheral zone . Severe differentiation and proliferation abnormalities occur during malignant transformation of the prostatic epithelium . These premalignant changes are associated with abnormal expression of growth factor receptors , oncogene and suppressor gene products and genetic instability . During the process of stromal invasion the transformed cells lose their basal cell phenotype and produce basement mem- brane-like matrices . Common prostate cancer is mainly composed of exocrine cell types that remain androgen-responsive even in hormone-independent disease . The frequent occurrence of neuroendocrine differentiation in common prostate cancer reflects the differentiation potency of its stem cells . The endocrine phenotype derives from exocrine tumor cells via intermediate ( amphicrine ) cell types . Neuroendocrine tumor cells consistently lack the nuclear androgen receptor and represent an androgen-insensitive cell population in prostate cancer ."
],
"offsets": [
[
0,
1987
]
]
}
] |
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DerPathologe.80190021.eng.abstr
|
DerPathologe.80190021.eng.abstr
|
[
{
"id": "DerPathologe.80190021.eng.abstr-passage-0",
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"The histological diagnosis of prostate cancer relies on a combination of structural and cytological findings . Structural features are assessed at low power magnification . Malignant glands are recognised by their abnormal size , shape and location in relation to the surrounding benign glandular structures . The presence of pathological intraluminal secretions ( pink amorphous secretions , crystalloids , blue-tinged mucinous secretions ) is always suspicious , but not diagnostic for prostate cancer . Cytological criteria including nuclear and nucleolar enlargement , hyperchromasia and cytoplasmic changes have to be evaluated in comparison with the cytological features of surrounding benign glands . The presence of prominent nucleoli is neither diagnostic for malignancy nor represents an absolute requirement for the diagnosis of prostate cancer . The basal cell layer is absent in invasive adenocarcinoma , an important feature that has to be evaluated with care since benign glands may also lack detectable basal cells . The immunohistochemical demonstration of basal cells with high molecular weight cytokeratins excludes invasive cancer . This article reviews the histological criteria for the diagnosis of prostate cancer , including variants of common adenocarcinoma and therapy-induced changes ."
],
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}
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] |
[] |
[] |
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DerPathologe.80190033.eng.abstr
|
DerPathologe.80190033.eng.abstr
|
[
{
"id": "DerPathologe.80190033.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Prostatic intraepithelial neoplasia ( HGPIN ) is considered the most likely precursor of clinically significant prostate cancer . Biopsy remains the only definitive method for detecting these premalignant lesions . In this article we review the diagnostic criteria of HGPIN and discuss histological features that allow their distinction from other benign and malignant lesions . PIN is recognised at low power magnification as a thickened , basophilic and hyperchromatic epithelium in pre-existing acinar duct structures . This important histological feature is due to nuclear crowding and stratification . Distinction between HGPIN and low grade PIN ( LGPIN ) , a lesion with little clinical significance , is made mainly on the presence or absence of prominent nucleoli . HGPIN lesions always retain an intact or fragmented basal cell layer . The different growth patterns of HGPIN ( tufting , micropapillary , cribriform and flat ) have no clinical significance but should be considered in the differential diagnosis together with normal structures , and both benign and malignant lesions . HGPIN has a high predictive value as a marker for prostate cancer but should not influence therapeutic decisions . Its identification in biopsy specimens warrants close surveillance with repeated biopsy ."
],
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DerPathologe.80190053.eng.abstr
|
DerPathologe.80190053.eng.abstr
|
[
{
"id": "DerPathologe.80190053.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Transrectal fine-needle aspiration biopsy ( FNAB ) of the prostate under digital control is a cheap and rapid method for diagnostic evaluation of palpable and non-palpable nodules , yielding high sensitivity ( ca. 95% ) and a low complication rate ( 1% ) . Its specificity amounts to > 97% . The scarcity of urologists trained in the FNAB method and of pathologists experienced in cytology of the prostate limit the clinical application so far . Besides various forms of prostatitis , five different types of cancer can cytologically be differentiated . While PIN I cannot be cytologically identified , PIN II/III lesions may lead to false-positive diagnoses . Cytologic grading of adenocarcinomas of the prostate is of statistically proven prognostic validity and strictly correlated with its histologic counterpart . Preoperative , radiologically controlled FNAB of pelvic and paraortal lymph nodes has sensitivity of ca. 86% and specificity of 100% . It thus helps to avoid unnecessary prostatectomies if nodal tumor spread has preoperatively been proven . Diagnostic DNA cytometry is able to identify those prostatic cancer patients who do not reveal significantly increased risk of tumor progression or decreased survival probability , even without therapy ( constantly and representatively diploid and tetraploid patterns ) . Patients with DNA tetraplid histograms may show detoriation of prognosis under hormonal therapy . DNA-aneuploid prostatic cancers should not be subjected to a \" wait and see \" strategy ; they do not respond to hormonal therapy ."
],
"offsets": [
[
0,
1560
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}
] |
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DerPathologe.80190059.eng.abstr
|
DerPathologe.80190059.eng.abstr
|
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DerPathologe.80190063.eng.abstr
|
DerPathologe.80190063.eng.abstr
|
[
{
"id": "DerPathologe.80190063.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Development and progression of tumors is driven by a malfunction of specific genes . Although prostate cancer is one of the most frequent tumors , little is known about the genes involved . Cytogenetic and molecular examinations have shown that chromosomal deletions most frequently involve 7q , 8p , 10q , 13q , 16q , 17p and the Y chromosome . These loci may carry tumor suppressor genes with relevance for prostate cancer . DNA sequence copy number gains were most frequently observed at chromosomes 7 , 8q , and 11q . These regions may carry currently un-known oncogenes . There is increasing evidence for a clinical relevance of genetic alterations . Polysomies of several chromosomes were shown to be associated with poor prog-nosis of prostate cancer patients . Androgen receptor amplification can be found in hormone-refractory carcinomas which may re-spond to total androgen blockage . For the future it is hoped that the identification of the genes involved in prostate cancer and the determination of their function could allow for significant improvements of treatment strategies for prostate cancer patients ."
],
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DerPathologe.80190069.eng.abstr
|
DerPathologe.80190069.eng.abstr
|
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"id": "DerPathologe.80190069.eng.abstr-passage-0",
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"text": [
"Spindle cell lesions of the prostate and surrounding tissues include mesenchymal and epithelial tumors and tumorlike lesions , such as postoperative spindle cell nodules ( PSN ) and pseudosarcomatous fibromyxoid tumors ( PFMT ) . PSN and PFMT are possibly related fibroblastic and myofibroblastic proliferations respectively . However , they may be misinterpreted as sarcomas ."
],
"offsets": [
[
0,
377
]
]
}
] |
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}
] |
[] |
[] |
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DerPathologe.80190074.eng.abstr
|
DerPathologe.80190074.eng.abstr
|
[
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"id": "DerPathologe.80190074.eng.abstr-passage-0",
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"text": [
"The surgical pathology of biopsies or electro-resection specimens taken from clinically sus-picious or overt tumors in the urinary bladder encompasses the evaluation of a few parameters . This should allow the segregation of bladder tumor patients into subgroups with distinct clinical features and biological behavior , thus providing a rationale for choos-ing the best available therapy . In essence , the pathologist's role entails a careful morphologic assessment of the primary tumor , including evaluation of the histologic type , the growth pattern , the tumor grade , the tumor stage , and finally the presence and type of primary or tumor-associated flat intraurothelial lesions . Whereas the growth pattern of a lesion can be readily recognized , the correct grading and staging of papillary tumors are often more dependent on the complexity of the individual case and the experience of the pathologist due to the inherent subjectivity of the field and a lack of standardized criteria . These problems of intra- and interobserver variability are intimately cou-pled with the characteristics of the material , that is , bad orientation and tangential sectioning , thermal injury , crush and fixation artifacts , and limitations of the size of the samples . The correct evaluation and interpretation of flat intraurothelial lesions suffer from similar difficulties and are further complicated by a confusing categorization and terminology . Although new modalities and molec-ular approaches have been introduced in recent years in an effort to overcome some of these obstacles , morphology still remains the most effective means to assess the bio-logical behavior and prognosis of urothelial bladder cancer . The present article therefore addresses some of the diagnostically and clinically most relevant controversies and aims to give some useful hints for the evaluation of the above-mentioned morpho-logical parameters . In addition , it adds some remarks on the morphological basis and diag-nostic validity of urinary cytology in primary diagnosis and , more importantly , monitoring of bladder cancer patients ."
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] |
[] |
[] |
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DerPathologe.80190095.eng.abstr
|
DerPathologe.80190095.eng.abstr
|
[
{
"id": "DerPathologe.80190095.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The phenotypic variability of epithelial ovarian neoplasms correlates with a diversity of changes on the molecular level . Invasive serous and undifferentiated ovarian carcinomas are characterized by p53 mutations , extensive loss of genetic material of chromosome 17 and complex changes on many other chromosomes . These alterations are seen only in a minority of mucinous and endometrioid carcinomas , mainly in ad- vanced stages . Overexpression of bcl-2 is seen most frequently in endometrioid carcinomas ( ca. 90% of cases ) , which in addition show microsatellite instability in around a third of cases , as has been described in endometrioid endometrial carcinomas . KRAS mutations are characteristic for mucinous LMP tumors ( borderline tumors ) and mucinous carcinomas ( 40-50% of cases ) . Furthermore , KRAS mutations have been described in around a third of serous LMP tumors , which in addition show microsatellite instability in up to 40% of cases . Serous LMP tumors never harbour complex chromosomal aberrations ."
],
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[
0,
1029
]
]
}
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] |
[] |
[] |
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DerPathologe.80190104.eng.abstr
|
DerPathologe.80190104.eng.abstr
|
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{
"id": "DerPathologe.80190104.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The article gives a review on oncocytic metaplasia and oncocytic tumors . Biochemical , cytochemical and molecular genetic findings are discussed . It has been established , that defects of the respiratory chain occur predominantly in oncocytic foci of the parathyroids and the liver . The underlying molecular genetic mechanisms are still unclear , however . In particular , one has to assume that oncocytic metaplasia differs pathogenetically from oncocytic neoplasia . Furthermore , organ-dependent prognostic differences of oncocytic tumors exist . Oncocytic carcinomas are predominantly seen in the thyroid and are scarce in other organs . The molecular genetic basis of this phenomenon is , however , still unknown ."
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[] |
[] |
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"id": "DerPathologe.80190104.eng.abstr-s7-r8-t2.2-t3.1",
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"id": "DerPathologe.80190104.eng.abstr-s7-r10-t2.2-t1.1",
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}
] |
DerPathologe.80190115.eng.abstr
|
DerPathologe.80190115.eng.abstr
|
[
{
"id": "DerPathologe.80190115.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Localized depositions of amyloid in the seminal vesicles may occur in elderly men . Ear-lier immunohistochemical studies have failed to identify immunoreactivity of known amyloid material . In this autopsy study , all seminal vesicles of males older than 50 years were histologically examined to determine incidence and phenotype of seminal vesicle amyloidosis . Seven out of 50 patients ( 14% ) showed depositions of amyloid in the seminal vesicles . These amyloid depositions as well as one additional case were characterized histochemically , immunohistochemically and electronmicroscopically . All but two of these patients ( 75% ) showed simultaneously amyloid depositions in the heart . Lactoferrin immunoreactivity was found in 6 patients ( 75% ) . Lactoferrin is an ironbinding , bacteriostatic glycoprotein , which is produced in the seminal vesicles . Four patients with lactoferrin positive amyloid in seminal vesicle showed different amyloid depositions in the heart ( immunoglobulin light chain amyloid AL-lambda ) . Two cases ( 25% ) showed the same amyloid type in heart and seminal vesicles ( prealbumin-transthyretin type amyloid ) . Our study shows that most amyloidoses of the seminal vesicles are organ-limited depositions of lactoferrin . These forms of localized amyloidosis have to be separated from senile systemic amyloidosis with seminal vesicle involvement ."
],
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"id": "DerPathologe.80190115.eng.abstr-s1-t2",
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"id": "DerPathologe.80190115.eng.abstr-s1-t3",
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"men"
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"id": "DerPathologe.80190115.eng.abstr-s1-t4",
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] |
DerPathologe.80190129.eng.abstr
|
DerPathologe.80190129.eng.abstr
|
[
{
"id": "DerPathologe.80190129.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Chronic rejection is a major problem in contemporary kidney transplantation . The purpose of this study was to determine whether renal cells are repopulated by extra-renal cells over time or whether the graft remains permanently allogenic . We studied nine explanted allografted kidneys of sex-mismatched donors by means of non-isotopic in situ hybridization ( NISH ) . We used biotinylated centromer-specific DNA probes of the human chromosomes Y and X. In a further step , monoclonal and polyclonal antibodies against CD45, CD3, CD20, CD31, CD1a, S100, -actin , factor VIII and UEA were used to analyse the various infiltrating cell types and the cells involved in allograft arteriopathy . In several cases NISH and immunohistochemistry were combined to facilitate the typing of cells . Our study showed that up to several years after transplantation the glomerular , tubular and endothelial cells retained donor origin . The only cells of recipient origin were the inflammatory cells , predominantly macrophages and T lymphocytes ."
],
"offsets": [
[
0,
1034
]
]
}
] |
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"id": "DerPathologe.80190129.eng.abstr-s1-t2",
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"kidney"
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"transplantation"
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"id": "DerPathologe.80190129.eng.abstr-s2-t4",
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}
]
},
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"id": "DerPathologe.80190129.eng.abstr-s3-t1",
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"id": "DerPathologe.80190129.eng.abstr-s3-t2",
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"id": "DerPathologe.80190129.eng.abstr-s3-t3",
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"id": "DerPathologe.80190129.eng.abstr-s3-t4",
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"id": "DerPathologe.80190129.eng.abstr-s4-t2",
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"id": "DerPathologe.80190129.eng.abstr-s4-t3",
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"id": "DerPathologe.80190129.eng.abstr-s4-t4",
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"text": [
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"id": "DerPathologe.80190129.eng.abstr-s4-t5",
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"id": "DerPathologe.80190129.eng.abstr-s4-t6",
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"id": "DerPathologe.80190129.eng.abstr-s4-t7",
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"id": "DerPathologe.80190129.eng.abstr-s4-t8",
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{
"id": "DerPathologe.80190129.eng.abstr-s4-t9",
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{
"id": "DerPathologe.80190129.eng.abstr-s4-t10",
"type": "umlsterm",
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},
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"id": "DerPathologe.80190129.eng.abstr-s4-t11",
"type": "umlsterm",
"text": [
"factor VIII"
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"id": "DerPathologe.80190129.eng.abstr-s4-t12",
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"the cells"
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"id": "DerPathologe.80190129.eng.abstr-s5-t1",
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"id": "DerPathologe.80190129.eng.abstr-s6-t1",
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}
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"id": "DerPathologe.80190129.eng.abstr-s6-t2",
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"id": "DerPathologe.80190129.eng.abstr-s6-t3",
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"id": "DerPathologe.80190129.eng.abstr-s6-t4",
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{
"id": "DerPathologe.80190129.eng.abstr-s7-t4",
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"id": "DerPathologe.80190129.eng.abstr-s7-t5",
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"id": "DerPathologe.80190129.eng.abstr-s7-t6",
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"text": [
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{
"db_name": "UMLS",
"db_id": "C0039194"
}
]
}
] |
[] |
[] |
[
{
"id": "DerPathologe.80190129.eng.abstr-s1-r1-t2.1-t3.3",
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{
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{
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{
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},
{
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{
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},
{
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"type": "assesses_effect_of",
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},
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},
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},
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},
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"id": "DerPathologe.80190129.eng.abstr-s4-r4-t1.1-t5.1",
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},
{
"id": "DerPathologe.80190129.eng.abstr-s4-r5-t5.1-t10.1",
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},
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{
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DerPathologe.80190134.eng.abstr
|
DerPathologe.80190134.eng.abstr
|
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"id": "DerPathologe.80190134.eng.abstr-passage-0",
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"The differential diagnosis of bullous and cystiform lung alterations comprises a relatively calculable number of various diseases , in which the most important are rare cystic tumors and congential malformations , such as adenomatoid cystic malformation . We report on a rare clinical picture . In this case , the clinical diagnosis of localized unilateral emphysema caused by local displacement and with subsequent complications had led to \" bullectomies \" and pneumonectomy . Macroscopi-cally , spongiform solid areas in association with areas of physaliform transformation were seen , corresponding histomorphologi-cally to villous , placentalike formations . The \" villous stroma \" revealed focally regressive alterations , fatty islets and leiomyomatous areas . So far , the pathogenesis of this lesion , described as \" placentoid malformation \" due to its pathognomonic histological appear-ance , remains unclear . In contradiction to the much discussed hypothesis that this lesion may develop from pre-existing lung emphysema , our results suggest that this may be an independent lesion , possibly congenital hamartous malformation with self-developing progression . The clinically predominant emphysematic alterations are considered to be caused by a valve mechanism due to unphysiological traction forces , the lymphatic path-ways regularly found in the border areas towards the original lung tissue , possibly playing an important etiological part."
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[] |
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DerPathologe.80190141.eng.abstr
|
DerPathologe.80190141.eng.abstr
|
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"A 67-year-old male patient presented with a nephrotic syndrome . Biopsy of the kidney revealed the characteristic of fibrillary glo-merulopathy on light and electron micros-copy . Other non-nephritic causes of a nephrotic syndrome ( e.g. amyloidosis , immunotactoid glomerulopathy , light-chain glomerulopathy , cryoglobulinaemia , collagen-III glomerulopathy , fibronectin glomerulopathy ) could be excluded . Besides the case report , differential diagnosis of fibrillary glomerulopathies is presented ."
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]
}
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[] |
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DerPathologe.80190146.eng.abstr
|
DerPathologe.80190146.eng.abstr
|
[
{
"id": "DerPathologe.80190146.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Leiomyosarcomas of the spermatic cord are very rare tumours , which , in contrast to the rhabdomyosarcoms of childhood , occur almost exclusively in adults . We report the case of a 51-year-old male patient with a metastasizing , pleomorphic leiomyosarcoma of the spermatic cord . The tumour showed paraneoplastic secretion of beta-chain human chorionic gonadotropin ( -hCG ) , as was demonstrated by the elevated levels of -hCG in serum samples and by immunohistochemistry . Histologically , the tumour was a high-grade leiomyosarcoma which showed an aggressive course with pulmonary metastases appearing 4 months after primary surgery . A concomitant rise in the serum levels of -hCG was also noted at this time . A wide spectrum of tumours with a choriocarcinomatous component or paraneoplastic production of -hCG has been described , the vast majority being carcinomas . Only two leiomyosarcomas producing -hCG have so far been reported . The paraneoplastic production of -hCG should prevent confusion with germ-cell tumours , especially teratomas ."
],
"offsets": [
[
0,
1053
]
]
}
] |
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{
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"adults"
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"id": "DerPathologe.80190146.eng.abstr-s2-t1",
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"male"
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"id": "DerPathologe.80190146.eng.abstr-s2-t3",
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},
{
"id": "DerPathologe.80190146.eng.abstr-s2-t4",
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"id": "DerPathologe.80190146.eng.abstr-s3-t1",
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"id": "DerPathologe.80190146.eng.abstr-s3-t2",
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"id": "DerPathologe.80190146.eng.abstr-s3-t3",
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"id": "DerPathologe.80190146.eng.abstr-s3-t6",
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"id": "DerPathologe.80190146.eng.abstr-s3-t7",
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"id": "DerPathologe.80190146.eng.abstr-s6-t2",
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}
] |
[] |
[] |
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DerPathologe.80190151.eng.abstr
|
DerPathologe.80190151.eng.abstr
|
[
{
"id": "DerPathologe.80190151.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report a coincidence of balloon cell melanoma and balloon cell transformation in a dermal nevus of a 56 years old female patient . The foamy cells in both tumors with different dignity expressed S-100 and Vimentin . HMB45 was expressed in all balloon cells of the melanoma . Detection of HMB45 in some of the nevus-associated balloon cells was considered as an expression of cellular activation ."
],
"offsets": [
[
0,
399
]
]
}
] |
[
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] |
[] |
[] |
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DerPathologe.80190154.eng.abstr
|
DerPathologe.80190154.eng.abstr
|
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"id": "DerPathologe.80190154.eng.abstr-passage-0",
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"We report a rare case of primary primitive neuroectodermal tumour of the bladder in an adult . A huge tumour with extensions into pelvic and retroperitoneal tissue was found radiologically in a 62-year-old man . The patient did not complain about remarkable clinical symptoms until 4 days before admission to hospital . Histology of diagnostic transurethral tumour resection showed a small round-cell tumour with focal necrosis and scattered Homer-Wright rosettes . Immunohistochemical analysis revealed that tumour cells stained positively with O13, a monoclonal antibody which recognizes the membrane glycoprotein p30/32MIC2. Focally , tumour cells stained positively for vimentin , NSE , S-100 protein and synaptophysin . The patient died 3 weeks later because of fulminant pulmonary embolism and autopsy revealed a huge , partly exophytic but mainly endophytic tumour of the bladder with extensions into the rectum and retroperitoneal tissue . The differential diagnosis of small round-cell tumours in this location is discussed ."
],
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}
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DerPathologe.80190187.eng.abstr
|
DerPathologe.80190187.eng.abstr
|
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{
"id": "DerPathologe.80190187.eng.abstr-passage-0",
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"When studying inflammation and wound healing , peculiar fibroblasts with ultrastructural similarities to smooth muscle cells were described by a group of pathologists associated with Guido Majno ( GM ) and Giulio Gabbiani ( GG ) , subsequently called myofibroblasts . Similar cells were also found later in human granulation tissue , palmar fibromatosis and in stromal reactions with invasive cancers . Their identification was facilitated by immunohistochemical methods . Some neoplastic cells , for instance in MFH , also revealed characteristics compatible with myofibroblasts . Myofibroblasts are conceived of as modulated fibroblasts . Cytokines may serve as mediators for activation and contractile modification of fibroblasts . In this context monitoring of a tumorlike overproduction of myofibroblasts or an underproduction with non-union of wounds might also be feasible . Moreover , better understanding of the role of myofibroblasts concerning the transition from in situ carcinomas into invasive growth may have therapeutic perspectives . Myofibroblasts apparently not only show a temporary existence in disease , but also can be found under normal conditions in several regions , such as the skin , periodontal ligaments , or pulmonary septa ."
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DerPathologe.80190194.eng.abstr
|
DerPathologe.80190194.eng.abstr
|
[
{
"id": "DerPathologe.80190194.eng.abstr-passage-0",
"type": "abstract",
"text": [
"In a retrospective study of a 12-year period ( 1981-1992 ) liver histology was analyzed in 227 autopsied patients infected with the human immunodeficiency virus . Normal histology could only be documented in 29 patients ( 13% ) . In the majority of cases ( 56% ) uncharacteristic changes were seen such as steatosis ( 34% ) , hemosiderosis ( 10% ) or non-specific reactive hepatitis ( 7% ) . The finding of hepatic peliosis obtained in 4 patients was not associated with inflammatory liver changes , especially infections from Rochalimaea . Within a wide range of opportunistic infections recorded in 50 patients ( 22% ) , hepatitis caused by Cytomegalovirus ( 8% ) , Toxoplasma gondii ( 5% ) , Leishmania donovani ( 1% ) , Cryptococcus neoformans and Pneumocystis carinii ( each 0.5% ) was diagnosed . Among 16 cases ( 7% ) of mycobacterial liver infections typical mycobacteria were found in two patients and atypical mycobacteria in 14 patients , respectively . In 23 patients ( 10% ) chronic viral hepatitis , caused by HBV ( 7% ) or HCV infections ( 3% ) , respectively , was observed . Hepatitis was typed as mild only in each 5 patients with HBV or HCV infection , whereas the remaining cases showed a transition towards cirrhosis . Two patients with HBV-associated cirrhosis developed hepatocellular carcinoma . The remaining 32 malignant liver tumors represented secondary neoplasms , including 13 cases of non-Hodgkin's lymphomas ."
],
"offsets": [
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1441
]
]
}
] |
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DerPathologe.80190209.eng.abstr
|
DerPathologe.80190209.eng.abstr
|
[
{
"id": "DerPathologe.80190209.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Diagnostic und therapeutic management of gastric lymphomas of the mucosa-associated lymphoid tissue type ( MALT-type lymphomas ) is often based exclusively on the evaluation of biopsy material . To evaluate the diagnostic value of gastric biopsies in gastric MALT-type lymphomas , biopsies - on average six per patient - and subsequent surgical specimens of 64 patients were compared at the Institute of Pathology , Unversity of Wuerzburg . Tumor diagnosis and tumor gradind were assessed . Using biopsy specimens , primary gastric MALT-type lymphomas were correctly diagnosed by local pathologists in 69% of cases , but correctly graded as low-grade , high-grade or secondary high-grade lymphomas in only 41% . When immunohistochemistry and molecular biological techniques were applied in addition to conventional histology , diagnosis of gastric MALT-type lymphoma was achieved in biopsies in 95% of cases at the Institute of Pathology Wuerzburg , but correct grading in only 73% . In secondary high-grade MALT-type lymphomas , both components - the high-grade and the low-grade component - were identified in gastric biopsies in only 33% of cases . Diagnostic accuracy in gastric lymphomas based on biopsies is limited by biopsy artefacts , but improved by using immunohistochemistry and molecular biological techniques . Particularly in secondary high-grade MALT-type lymphomas the correct diagnosis is often missed when using biopsies , due to a low number of biopsy specimens ."
],
"offsets": [
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1483
]
]
}
] |
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DerPathologe.80190214.eng.abstr
|
DerPathologe.80190214.eng.abstr
|
[
{
"id": "DerPathologe.80190214.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Because of the rising importance of talcum pleurodesis in the therapeutic management of malignant and benign pleural effusions in Germany , pleural samples after talcum pleurodesis were compared to microscopic , immunohistochemical , and scanning electron microscopy findings after Tetracyclin and Novantron pleurodesis in 24 patients up to 18 months after intrapleural therapy . The histomorphological findings after talcum pleurodesis show an early phase of up to 4 weeks , characterized by the presence of talcum-containing granulation tissue with giant-cell foreign-body reaction , and a subsequent late phase with organization of the granulation tissue and connective tissue formation and obliteration of the pleura sheets . The resulting characteristic linear talcum zone in the pleural connective tissue is missing in cases with tumorous infiltration of the pleura . Continuous fibroblast activation , e.g. , by macrophage or foreign-body giant-cell-released mediators , seems to be the decisive factor in the fibrosing process . No therapy-related tumor growth alterations could be demonstrated ."
],
"offsets": [
[
0,
1104
]
]
}
] |
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DerPathologe.80190221.eng.abstr
|
DerPathologe.80190221.eng.abstr
|
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{
"id": "DerPathologe.80190221.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The occurrence of plasmodial giant cells in the liver is probably a morphological reaction pattern with the most diverse causes . In babies and infants , these changes occur in particular in neonatal hepatitis and intrahepatic and extrahepatic bile duct atresia . Viral infections and/or autoimmune reactions are discussed etiologically in giant cell hepatitis in adults ( adult giant cell hepatitis , AGCH ) , which is much rarer . In some of the cases , there were conspicuously high titers against paramyxoviruses . Giant cell hepatitis can occur in the course of HIV infection . These both indicate an infectious cause . However , the disease cannot be transmitted to chimpanzees . Apart from our case , only one further case is described in the literature in which a completed hepatitis A infection could be demonstrated serologically . In addition , the titer of antinuclear antibodies was raised in our patient . This autoimmune phenomenon is probably of crucial pathogenetic significance in our patient , especially since a hepatitis A infection on its own does not afford an adequate etiological explanation for the form of chronic and active hepatitis with consecutive cirrhotic transformation observed here ."
],
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DerPathologe.80190226.eng.abstr
|
DerPathologe.80190226.eng.abstr
|
[
{
"id": "DerPathologe.80190226.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report a 44-year-old female patient who underwent surgery because of a suspected primary tumor of the renal pelvis in imaging procedures . Histology revealed the diagnosis of mesoblastic nephroma . This tumor represents a special entity of nephroblastoma that rarely occurs in adults . There is no unanimous opinion on the biological behavior of mesoblastic nephroma because the tumor behaves differently . The question of whether nephrectomy is indicated if there are no malignant features is also open . The decision depends on the given case . Nephrectomy can only be avoided if the intraoperative situation allows the tumor to be removed with an adequate distance from healthy tissue . The safety margin is necessary because mesoblastic nephroma shows fingerlike spread into the surrounding tissue ."
],
"offsets": [
[
0,
806
]
]
}
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"surgery"
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{
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"imaging procedures"
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121,
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{
"id": "DerPathologe.80190226.eng.abstr-s2-t1",
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"Histology"
],
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]
},
{
"id": "DerPathologe.80190226.eng.abstr-s2-t3",
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"nephroma"
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},
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"id": "DerPathologe.80190226.eng.abstr-s2-t4",
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],
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},
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"id": "DerPathologe.80190226.eng.abstr-s3-t2",
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"id": "DerPathologe.80190226.eng.abstr-s5-t1",
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"id": "DerPathologe.80190226.eng.abstr-s5-t2",
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]
}
] |
[] |
[] |
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DerPathologe.80190230.eng.abstr
|
DerPathologe.80190230.eng.abstr
|
[
{
"id": "DerPathologe.80190230.eng.abstr-passage-0",
"type": "abstract",
"text": [
"About 10% of all nephroblastomas ( Wilms ' tumor ) present as part of malformation syndromes . The Denys-Drash syndrome ( DDS ) comprises pseudohermaphroditism , glomerulopathy and , early , often bilateral Wilms ' tumors . A nephrectomy was performed in a 4-month-old girl because of a Wilms ' tumor . Two months later , low serum albumin levels and proteinuria had developed . A biopsy from the remaining kidney showed a glomerulopathy which could also be seen in the nephrectomy specimen . The morphology was highly characteristic : the innermost layer of the kidney cortex exhibited augmentation of the mesangial matrix only ; the intermediate layer showed severe sclerosis of glomeruli with deposition of fibrillary material ; and the subcapsular layer revealed very small glomeruli and atrophic tubuli . Fifteen months later , peritoneal dialysis was necessary and due to the high risk of tumor development in the remaining kidney , a nephrectomy was performed . Molecular analysis revealed a point mutation within exon 9 of the WT1 gene ( 394 ARG- > TRP ) , which was homozygous in the tumor and heterozygous within renal parenchyma . The DDS is caused by a mutation in the WT1 gene on chromosome 11p13 which occurs during oogenesis or spermiogenesis . The WT1 gene is highly expressed during the development of the genitalia and the kidney ; damage in one allele only causes the malformation syndrome . Loss of the second allele of the WT1 gene constitutes the second step of tumorigenesis . The appearance of Wilms ' tumors derived from cells homozygous for the mutation reveals the function of the WT1 gene as a tumor suppressor gene ."
],
"offsets": [
[
0,
1645
]
]
}
] |
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"tumor"
],
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]
],
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{
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{
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{
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{
"id": "DerPathologe.80190230.eng.abstr-s2-t2",
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{
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{
"id": "DerPathologe.80190230.eng.abstr-s2-t4",
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{
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"nephrectomy"
],
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],
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{
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},
{
"id": "DerPathologe.80190230.eng.abstr-s4-t2",
"type": "umlsterm",
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],
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"id": "DerPathologe.80190230.eng.abstr-s4-t3",
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DerPathologe.80190259.eng.abstr
|
DerPathologe.80190259.eng.abstr
|
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"The histologic determination of the degree of tissue anaplasia and grade of malignancy of gliomas is based upon qualitative histological features ( nuclear pleomorphism , mitoses , endothelial proliferation , tumor necrosis ) . This grading approach is influenced by the subjective interpretation of the pathologist , especially concerning the weighting of criteria ( scant , moderate , pronounced ) . An observer-independent approach seems to be feasible by abandoning the concept of parameter weighting in favor of an binary approach noting only the presence or absence of these structure parameters . This grading procedure is recognized in the revised WHO classification of brain tumors for common type astrocytomas ( Ste . Anne-Mayo System , SAMS ) . Our results indicate that a similiar approach is also suitable for grading purposes of oligodendrogliomas and mixed gliomas . Our recent investigations on glioma grading showed , both for astrocytomas and oligodendrogliomas , that a two-tiered grading scheme distinguishing only \" low-grade \" and \" high-grade \" cases was prognostically relevant . For all glioma entities the onset of tumor angiogenesis with endothelial proliferation and contrast enhancement in CT and MRI seems to be the key criterion indicating irreversible tumor progression to the \" high \" malignancy grade ."
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DerPathologe.80190269.eng.abstr
|
DerPathologe.80190269.eng.abstr
|
[
{
"id": "DerPathologe.80190269.eng.abstr-passage-0",
"type": "abstract",
"text": [
"During the last few years , the molecular basis of several cancer predisposition syndromes has been discovered which offers new tools for cancer prevention and early detection . This will be demonstrated in one of the most frequent hereditary cancer syndromes , namely the hereditary nonpolyposis colorectal cancer ( HNPCC ) which accounts for about 5% to 8% of CRC . Thereby , families with exclusively CRC ( Lynch type I syndrome ) and those with extracolonic cancers especially of endometrium , stomach , small bowel and upper urinary tract ( Lynch type II syndrome ) can be discriminated . At the molecular level , HNPCC is caused by germline mutations in one of the mismatch repair genes ( hMSH2, hMLH1, hMSH6, hPMS2). Thus , nucleotide mispairings occurring particularly within simple repetitive genomic sequences ( microsatellites ) during replication are no longer be repaired properly and can be demonstrated by PCR as so-called microsatellite instability ( MSI ) . Since more than 90% of HNPCC associated and only about 15% of sporadic CRC show MSI , this test is a useful tool for HNPCC screening . In case of a negative result HNPCC is highly unlikely . In positive cases ( with > =2 out of 5 unstable defined microsatellite markers ) the definite molecular diagnosis can only be obtained by sequencing the mismatch repair genes from the patient's blood or normal DNA . As immunohisto-chemistry reveals loss of hMSH2 or hMLH1 expression in most MSI positive CRC , these data provide useful information for the sequencing strategy . Molecular tumor screening by MSI test and immunohistochemistry is recommended in patients i . ) with a positive family history ( acc . to the Amsterdam criteria ) , ii . ) suffering from multiple HNPCC related carcinomas , iii . ) with HNPCC related cancer before 45ys of age , and iv . ) with right-sided CRC exhibiting medullary , signet-ring or mucinous differentiation . Finally , these tests as well as genetic counseling and treatment of the patient need to be done by an interdisciplinary approach . Thereby , the pathologist can substantially contribute to identify HNPCC related carcinomas either by clinical or morphological criteria and to initiate the molecular screening test ."
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] |
DerPathologe.80190286.eng.abstr
|
DerPathologe.80190286.eng.abstr
|
[
{
"id": "DerPathologe.80190286.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Juvenile pleomorphic adenoma of the parotid gland represents an extremely rare tumour entity and is comparable to congenital tumours of the salivary glands concerning its embryonal structure . The clinical detection of the tumour in a 7-year-old girl does not exclude that the tumour had developed either earlier or immediately after the birth . The high cellularity and the evidence of primitive epithelial and myoepithelial cellular structures do not justify its classification as a malignant tumour . However the presence of embryonal tissue structures associated with the end of the third month of embryogenesis is characterized by more solid cell formations in partly verticillate arrangement . The absence of further differentiation into lobular structures and differentiated duct or acinic cell formations may be due to cell arrest . Differential diagnosis of juvenile pleomorphic adenoma must distinguished it from other congenital salivary gland tumours ( e.g. congenital basal cell adenoma , hybrid basal cell adenoma - adenoid cystic carcinoma , sialoblastoma , salivary gland anlage tumour ) ."
],
"offsets": [
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]
]
}
] |
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},
{
"id": "DerPathologe.80190286.eng.abstr-s1-t2",
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"text": [
"parotid"
],
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{
"id": "DerPathologe.80190286.eng.abstr-s1-t3",
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"text": [
"tumour"
],
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{
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"congenital"
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{
"id": "DerPathologe.80190286.eng.abstr-s1-t6",
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},
{
"id": "DerPathologe.80190286.eng.abstr-s1-t7",
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"id": "DerPathologe.80190286.eng.abstr-s2-t1",
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"id": "DerPathologe.80190286.eng.abstr-s2-t2",
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{
"id": "DerPathologe.80190286.eng.abstr-s2-t3",
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"birth"
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"id": "DerPathologe.80190286.eng.abstr-s3-t1",
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"id": "DerPathologe.80190286.eng.abstr-s3-t2",
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"id": "DerPathologe.80190286.eng.abstr-s3-t4",
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"id": "DerPathologe.80190286.eng.abstr-s4-t2",
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"id": "DerPathologe.80190286.eng.abstr-s6-t1",
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] |
[] |
[] |
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DerPathologe.80190299.eng.abstr
|
DerPathologe.80190299.eng.abstr
|
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],
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[] |
[] |
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DerPathologe.80190305.eng.abstr
|
DerPathologe.80190305.eng.abstr
|
[
{
"id": "DerPathologe.80190305.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Nevus cell aggregates in lymph nodes are uncommon . This benign phenomenon may be difficult to differentiate from metastatic neoplasia . We report the case of a 56-year-old patient who underwent breast biopsy , followed by radical mastectomy including lymphadenectomy . Histological examination revealed solid cell aggregates as foreign tissue in the capsule of 1 of 11 identified lymph nodes devoid of any keratin immunoreaction . Strong immunohistological staining for the S-100 protein confirmed the diagnosis of nevus cell aggregates ."
],
"offsets": [
[
0,
539
]
]
}
] |
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5
]
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],
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10
]
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DerPathologe.80190308.eng.abstr
|
DerPathologe.80190308.eng.abstr
|
[
{
"id": "DerPathologe.80190308.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Myositis proliferans is a reactive , intramuscular soft tissue disease characterized by fibroblast and myofibroblast proliferation , showing similarities to the phase-like development seen in the general pathology of wound healing and hypertrophic scars . Immunohistochemically , a combined expression of vimentin and alpha-sm actin is seen in the spindle-shaped cell formations . The decisive histological preparation is supported by immunohistochemical techniques , especially in the differentiation from sarcoma . If a definite diagnosis is made , incomplete excision may suffice ."
],
"offsets": [
[
0,
584
]
]
}
] |
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{
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"id": "DerPathologe.80190308.eng.abstr-s1-t10",
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}
] |
[] |
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DerPathologe.80190313.eng.abstr
|
DerPathologe.80190313.eng.abstr
|
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"id": "DerPathologe.80190313.eng.abstr-passage-0",
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"In situ polymerase chain reaction ( PCR ) and PCR in situ hybridization are new diagnostic tools in dermatopathology . These techniques can combine the sensitivity of PCR with the advantage of in situ hybridization to localize specific cellular structures . With optical control of the PCR reaction product in these techniques , false-positive results due to contamination can be minimized . Several working protocols have been established which allow detection of DNA and RNA sequences in a rapid and reproducible manner . Two different methods have been established to detect the amplification product , the indirect PCR in situ hybridization ( PCRisHyb ) , and the direct in situ PCR ( is PCR ) . An easy and reproducible method for PCRisHyb and isPCR in formalin-fixed and paraffin-embedded tissue is described and the two techniques are compared . Using both isPCR and PCRisHyb , the amplification product can be visualized with an optimal morphological preservation of the tissue . Indirect PCRisHyb showed a slightly higher specificity whereas direct isPCR was the quicker , easier and less expensive method ."
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}
] |
[] |
[] |
[
{
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{
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] |
DerPathologe.80190318.eng.abstr
|
DerPathologe.80190318.eng.abstr
|
[
{
"id": "DerPathologe.80190318.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Telepathology , defined as the practice of pathology over a distance by viewing images transmitted from a remote site , was previously analyzed mainly with respect to technical equipment and diagnostic accuracy compared with conventional histological diagnosis . In this paper , telepathology is analyzed with regard to economic points of view , demonstrating the background for the cost-benefit analysis of telepathology . The acquisition cost and the operating costs of a telepathology system are compared with potential cost-saving and other benefits from telepathology . This analysis may help to decide whether or not telepathology should be established in a hospital ."
],
"offsets": [
[
0,
674
]
]
}
] |
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[] |
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DerPathologe.80190325.eng.abstr
|
DerPathologe.80190325.eng.abstr
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DerPathologe.80190337.eng.abstr
|
DerPathologe.80190337.eng.abstr
|
[
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"Nasopharyngeal carcinomas ( NPC ) belong to the most frequent malignant tumours in certain parts of the world , e . g . , south-east Asia , while they occur infrequently in western Europe . The association of NPCs with Epstein-Barr virus ( EBV ) , a transforming human herpes virus , is well established . The current WHO classification recognises two major NPC histotypes , non-keratinising NPC and squamous cell NPC . EBV is invariably present in non-keratinising NPCs and the viral oncoprotein LMP-1 ( latent membrane protein-1) is expressed in some cases . The tumour cells of non-keratinising NPCs show phenotypic features which are inducible by LMP-1 in vitro . These may contribute to the development of the lymphoid stroma which is characteristic of this tumour type . Furthermore , the virus is detectable in nasopharyngeal carcinoma in situ . Thus , the virus is likely to be involved in the pathogenesis of non-keratinising NPCs . By contrast , the association of squamous cell NPCs with EBV displays a geographical variability . It appears , therefore , that squamous cell NPCs are a heterogenous group of tumours distinct from non-keratinising NPCs ."
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}
] |
[] |
[] |
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] |
DerPathologe.80190345.eng.abstr
|
DerPathologe.80190345.eng.abstr
|
[
{
"id": "DerPathologe.80190345.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Amyloid is a biophysically defined , biochemically non-uniform protein which is deposited in the tissue , forming a cross-beta configuration . In paraffin sections it is demonstrated using Congo red staining according to Puchtler et al. and a polarizing microscope with a tension-free clean optic system that shows a typical apple-green birefringence . The identification of amyloid has to be followed by immunostaining for AA , ATTR , Alambda , Akappa and A2 microglobulin and possibly further types of amyloids for classification purposes . Considering the localization , expansion and type localized and generalized types probably can be differentiated . The latter should be correlated to a basic disease . The treatment of the basic disease is the only chance for reducing or eliminating the amyloid deposits . In this review , the modern morphological methods for demonstration and both immunohistological and clinical classification of amyloid and amyloidoses are presented . Rare types are mentioned in the tables ."
],
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[
0,
1023
]
]
}
] |
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"id": "DerPathologe.80190345.eng.abstr-s1-t2",
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{
"id": "DerPathologe.80190345.eng.abstr-s1-t4",
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{
"id": "DerPathologe.80190345.eng.abstr-s2-t4",
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"id": "DerPathologe.80190345.eng.abstr-s3-t2",
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"id": "DerPathologe.80190345.eng.abstr-s3-t3",
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"id": "DerPathologe.80190345.eng.abstr-s3-t4",
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]
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] |
DerPathologe.80190368.eng.abstr
|
DerPathologe.80190368.eng.abstr
|
[
{
"id": "DerPathologe.80190368.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The possible relation of acquired cystic kidney disease to renal cell carcinoma resulted in an interdisciplinary concern about this disease . Kidneys from 125 autopsies of dialysis patients were studied . Twenty-four of the patients had tumors . Beside four renal adenocarcinomas and two urothelial carcinomas , incidental small tumor nodules were described in 15.1% . Men had more nodules than women . Patients with nodules had a higher average cyst count , often with multilayered epithelium . There was no difference in age or time of dialysis . This suggests a factor which mediates cyst and tumor proliferation , independent from the time of dialysis ."
],
"offsets": [
[
0,
657
]
]
}
] |
[
{
"id": "DerPathologe.80190368.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"kidney"
],
"offsets": [
[
41,
47
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0022646"
}
]
},
{
"id": "DerPathologe.80190368.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"disease"
],
"offsets": [
[
48,
55
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0012634"
}
]
},
{
"id": "DerPathologe.80190368.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"cell"
],
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[
65,
69
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0007634"
}
]
},
{
"id": "DerPathologe.80190368.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"carcinoma"
],
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[
70,
79
]
],
"normalized": [
{
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"db_id": "C0007097"
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{
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"disease"
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}
]
},
{
"id": "DerPathologe.80190368.eng.abstr-s1-t6",
"type": "umlsterm",
"text": [
"cystic kidney"
],
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[
34,
47
]
],
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{
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"db_id": "C0022679"
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},
{
"id": "DerPathologe.80190368.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"kidney disease"
],
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},
{
"id": "DerPathologe.80190368.eng.abstr-s1-t8",
"type": "umlsterm",
"text": [
"cystic kidney disease"
],
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34,
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DerPathologe.80190373.eng.abstr
|
DerPathologe.80190373.eng.abstr
|
[
{
"id": "DerPathologe.80190373.eng.abstr-passage-0",
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"Squamous metaplasia can be demonstrated in about 4% of all invasive carcinomas of the breast . Primary squamous cell carcinomas of the breast are rare , since they occur in less than 1% of all primary invasive breast carcinomas . In order to classify a breast tumor as a primary squamous cell carcinoma one must exclude an epidermal origin , especially from the nipple region and the possibility of metastatic infiltration of the breast by a squamous cell carcnoma from a different location . Causative and formal pathogenesis of primary squamous cell carcinoma of the breast is not clear . A pluripotent embryonal stem cell origin is discussed , considering the phylogenetic descent of the mammary gland from skin appendages . Squamous metaplasia is also suggested to be a precursor of squamous cell carcinoma . Here endocrine stimulation and chronic inflammation may both play an inductive role . The number of published cases of squamous cell carcinomas developing years and decades after implantation of silicon prostheses has increased in recent years . These tumors probably develop on top of squamous metaplasia induced by the inflammatory pseudocapsule ."
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[] |
[] |
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DerPathologe.80190379.eng.abstr
|
DerPathologe.80190379.eng.abstr
|
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[] |
[] |
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DerPathologe.80190384.eng.abstr
|
DerPathologe.80190384.eng.abstr
|
[
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"id": "DerPathologe.80190384.eng.abstr-passage-0",
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"Histologic , immunohistochemical and ultrastructural results of a rhinoscleroma diagnosed bioptically on a 38 aged man are demonstrated . The characteristic light microscopic sign is a plasmocytic inflammatory infiltrate with dense packed foamy transformed macrophages ( Mikulicz cells ) ultrastructurally containing diplobacilli ( Klebsiella rhinoscleromatis , gram negative agent of the lesion ) . The lesion has to be differentiated as of other inflammatory diseases as of plasmocytoma . A local application of acriflavin solution 2% was of therapeutical benefit ."
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[] |
[] |
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DerPathologe.80190403.eng.abstr
|
DerPathologe.80190403.eng.abstr
|
[
{
"id": "DerPathologe.80190403.eng.abstr-passage-0",
"type": "abstract",
"text": [
"One hundred and three cases of Spitz nevi were reviewed . 36% of these patients were adults . The lesions in children occurred primarily on the face and secondarily on the trunk followed by the extremities . In adults , they affect the legs in women , and the trunk in men as does malignant melanoma . Clinically they were diagnosed more frequently as Spitz nevi in children and adolescents than in adults . Spitz nevi were most commonly mistaken clinically for \" common \" melanocytic nevus , hemangioma , verruca , fibrous histiocytoma , molluscum contagiosum , granuloma pyogenicum , keloid , and melanoma . Histologically , there are various expressions of Spitz nevi , but they are usually compound melanocytic nevi with little pigmentation and typically large spindle- and/or epithelioid melanocytes . There are only small histopathological differences between Spitz nevi in childhood and adulthood : one important feature rarely seen in Spitz nevi of adults is multiple mitotic figures at the dermo-epidermal junction but rarely at the base of the melanocytic nevus . Nevus Reed is considered to possibly be a distinctly pigmented variant of Spitz nevus ."
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] |
[] |
[] |
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] |
DerPathologe.80190412.eng.abstr
|
DerPathologe.80190412.eng.abstr
|
[
{
"id": "DerPathologe.80190412.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Dermatofibroma is a common benign fibrohistiocytic lesion which presents with a wide variety of clinicopathologic variants . This may cause great difficulties in delineation from a variety of benign and malignant tumours . According to their peculiarities we differentiate : 1. Dermatofibromas with architectural peculiarities like deep penetrating , atrophic , giant , aneurysmal ( \" angiomatoid \" ) , haemangiopericytoma-like , palisading or ossifying variants . 2. Dermatofibromas with cellular/stromal peculiarities like clear cell , granular cell , myofibroblastic , sclerotic , monster cell , atypical ( \" pseudosarcomatous \" ) , elusive ( \" haemosiderotic \" ) , cholesterotic , and myxoid variants . 3. Dermatofibromas with architectural and cellular/stromal peculiarities in homogenous arrangement like epithelioid cell , cellular benign variants , with smooth muscle proliferation , basal cell carcinoma-like , pseudolymphomatous , multinucleate cell angiohistiocytoma , cellular neurothekeoma , plexiform fibrohistiocytic tumour , plexiform xanthoma and plexiform xanthomatous tumour . 4. Complex or composite dermatofibromas with two or more architectural and cellular/stromal peculiarities in inhomogenous arrangement , e.g. silhouette of an epithelioid cell histiocytoma with plexiform fascicles of cellular neurothekeoma and granular cell features ."
],
"offsets": [
[
0,
1363
]
]
}
] |
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],
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0,
14
]
],
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]
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{
"id": "DerPathologe.80190412.eng.abstr-s2-t1",
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"malignant"
],
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{
"id": "DerPathologe.80190412.eng.abstr-s2-t2",
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"text": [
"tumours"
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"id": "DerPathologe.80190412.eng.abstr-s4-t2",
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"id": "DerPathologe.80190412.eng.abstr-s4-t6",
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"id": "DerPathologe.80190412.eng.abstr-s5-t1",
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"id": "DerPathologe.80190412.eng.abstr-s5-t2",
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"id": "DerPathologe.80190412.eng.abstr-s5-t5",
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"id": "DerPathologe.80190412.eng.abstr-s5-t7",
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] |
DerPathologe.80190420.eng.abstr
|
DerPathologe.80190420.eng.abstr
|
[
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"Calcification is one of the main causes of failure of porcine bioprosthetic heart valves , a problem which has not been satisfactorily solved to date . Previous studies have shown that calcification is decreased in porcine heart valves that have undergone treatment for lipid extraction . The relation between lipid distribution and calcification of seven new commercially available porcine bioprosthetic heart valves ( St. Jude Medical , Bioimplant ) is assessed by Sudan red III staining to show preexisting lipids . All porcine bioprosthetic valves contained lipids to different degrees . Five valves were subjected to the pulsatile accelerated calcification process for 4 weeks . Distribution and level of calcification were evaluated by radiography and compared to the Sudan red-stained fatty areas . Comparison of the calcifications detected by radiography and the macroscopically detected lipids showed a coincidence of 57-66% . Two porcine bioprosthetic valves were histologically prepared and stained with Hematoxylin and von Kossa's stain , respectively . By light microscopy , the von Kossa staining revealed microcalcifications and polarizing microscopic investigation showed birefractive substances in areas with lipid deposits . These preexisting substances in porcine valve tissue may play a determinative role in the calcification of the tissue . Substantial studies are necessary to further determine the role of preexisting lipids in calcification ."
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] |
DerPathologe.80190425.eng.abstr
|
DerPathologe.80190425.eng.abstr
|
[
{
"id": "DerPathologe.80190425.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Lung dust analyses were performed on tumor-free lung tissue from surgical samples of 28 carcinoid tumors . The measured levels in one surgical sample may easily be correlated with the increased asbestos load of the lung due to the patients ' occupation as stone mason . No evidence supporting the correlation of increased chronic asbestos load of the lungs and the development of typical carcinoid tumors of the lung was found ."
],
"offsets": [
[
0,
428
]
]
}
] |
[
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4
]
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}
]
},
{
"id": "DerPathologe.80190425.eng.abstr-s1-t2",
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"text": [
"dust"
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]
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{
"id": "DerPathologe.80190425.eng.abstr-s1-t3",
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18
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}
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},
{
"id": "DerPathologe.80190425.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"tumor-free"
],
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]
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},
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"id": "DerPathologe.80190425.eng.abstr-s1-t5",
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"lung"
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]
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]
},
{
"id": "DerPathologe.80190425.eng.abstr-s1-t6",
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"text": [
"tissue"
],
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53,
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]
],
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]
},
{
"id": "DerPathologe.80190425.eng.abstr-s1-t7",
"type": "umlsterm",
"text": [
"surgical"
],
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65,
73
]
],
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}
]
},
{
"id": "DerPathologe.80190425.eng.abstr-s1-t8",
"type": "umlsterm",
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"carcinoid"
],
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},
{
"id": "DerPathologe.80190425.eng.abstr-s1-t9",
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"text": [
"tumors"
],
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104
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},
{
"id": "DerPathologe.80190425.eng.abstr-s1-t10",
"type": "umlsterm",
"text": [
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],
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88,
104
]
],
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"db_id": "C0007095"
}
]
},
{
"id": "DerPathologe.80190425.eng.abstr-s2-t1",
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"text": [
"surgical"
],
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134,
142
]
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]
},
{
"id": "DerPathologe.80190425.eng.abstr-s2-t2",
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],
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202
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],
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},
{
"id": "DerPathologe.80190425.eng.abstr-s2-t3",
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"lung"
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215,
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],
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},
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"id": "DerPathologe.80190425.eng.abstr-s2-t4",
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"patients"
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]
],
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"db_id": "C0030705"
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]
},
{
"id": "DerPathologe.80190425.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"occupation"
],
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252
]
],
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"db_id": "C0028811"
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},
{
"id": "DerPathologe.80190425.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"asbestos"
],
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330,
338
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],
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}
]
},
{
"id": "DerPathologe.80190425.eng.abstr-s3-t2",
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"text": [
"lungs"
],
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351,
356
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],
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},
{
"id": "DerPathologe.80190425.eng.abstr-s3-t3",
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]
},
{
"id": "DerPathologe.80190425.eng.abstr-s3-t4",
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},
{
"id": "DerPathologe.80190425.eng.abstr-s3-t5",
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{
"id": "DerPathologe.80190425.eng.abstr-s3-t6",
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},
{
"id": "DerPathologe.80190425.eng.abstr-s3-t7",
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}
]
}
] |
[] |
[] |
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DerPathologe.80190430.eng.abstr
|
DerPathologe.80190430.eng.abstr
|
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{
"id": "DerPathologe.80190430.eng.abstr-passage-0",
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"text": [
"Univentricular hearts represent rare complex cardial malformations . We report a case of a 34-year old male with single ventricle , two atria , tricuspid atresia , large atrial septal defect , complete transposition and pulmonary valvar stenosis . There were no signs of chronic pulmonary hypertension . Intensive clinical analysis of the cardiac malformation was first performed at the age of five years . Conclusion was that the patient would have no benefit from operation . The patient had nearly normal live conditions with a profession , family and some sportive activities like squash . He died of sudden cardiac death . The malformation was examined by sequential segmental analysis and in comparison with the embryonic development . Special features are emphasized . Clinical picture , prognosis and therapy are reported from literature . During the last years development of cardiac surgery achieved good results . Special morphologic constellations , as in our case , may be the reason that conservative therapy can be sufficient for prolonged survival with good quality of life ."
],
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]
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}
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DerPathologe.90200006.eng.abstr
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DerPathologe.90200006.eng.abstr
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[] |
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DerPathologe.90200009.eng.abstr
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DerPathologe.90200009.eng.abstr
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"id": "DerPathologe.90200009.eng.abstr-passage-0",
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"Tumor classification , grading and staging of malignant tumors of the cervix and corpus uteri should be done according to the rules of the WHO fascicle of 1994 and the TNM manual of 1997 , respectively . With these lines taking into account , the surgical pathology report will include the most important prognostic factors , which in part are also of therapeutic relevance , i.e. localization of the lesion , depth of invasion and distant tumor manifestation . Yet , gross inspection and preparation are the prerequisites of the quality of the histopathological statement . Accurate documentation of tumor extension , depth of invasion into the cervical stroma and/or the myometrium and distance to the resection lines at the vaginal cuff and the parametrium needs to be given in centimeters , first by eye , than controlled by histopathology . The tumor extension of cervical carcinomas should be given in three dimensions , including the depth of invasion into the cervical wall . It is also mandatory to document the number and size of lymph nodes with metastatic involvement compared to the total number of nodes which are discovered in parametral , pelvioperitoneal and paraaortal sites . Most of what has been outlined for the surgical pathology report of hysterectomy specimens is also pertinent to conisations , by whatever method these are performed ( cold knife , laser or loop ) . For appropriate documentation of the localization of the lesion , horizontal expansion of the dysplastic lesion and recognition of microinvasion it is sufficient to dissect the conisation specimen clockwise and to cut the various paraffin blocks in serial sections ."
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DerPathologe.90200015.eng.abstr
|
DerPathologe.90200015.eng.abstr
|
[
{
"id": "DerPathologe.90200015.eng.abstr-passage-0",
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"Cervical carcinomas and their precursors ( cervical dysplasia , CIN1-3) are associated with human papillomavirus ( HPV ) infections . Epidemiological and in vitro-studies have shown that some of the genital HPV types , the high risk-types 16 , 18 , 31 etc. , code for proteins ( E6/E7) which strongly influence the cell cycle and genome stability . Progression from weak to severe dysplasia and to invasive cancer is associated with increasing expression of these viral oncogenes . Which additional cofactors contribute to progression of some dysplasias to carcinomas is still a matter of investigation . Recent results point to genetic predisposition ( p53 polymorphism ) , cellular immune reaction , and cytokine expression . For HPV detection in cervical swabs and biopsies two highly sensitive and reliable systems ( PCR , Hybrid Capture system ) are available . Although classical histological methods are sufficient for the diagnosis of high-grade lesions and invasive cancer , HPV testing might give valuable diagnostic and prognostic clues especially in cases of unclear cytology ( ASCUS ) or weak dysplasia ."
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DerPathologe.90200025.eng.abstr
|
DerPathologe.90200025.eng.abstr
|
[
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"id": "DerPathologe.90200025.eng.abstr-passage-0",
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"text": [
"Dysplastic epithelia represent potentially precancerous conditions in which the risk of progression to cancer is unknown in the individual case . The positive predictive value of mild and moderate dysplasias of the uterine cervix is only about 13% . Using DNA image cytometry on restained , conventional Pap-smears the cytometric equivalent of chromosomal aneuploidy can be detected as marker for neoplastic transformation of cells . The identification of DNA aneuploidy in dysplastic squamous epithelia can increase the predictive value for malignant transformation to over 90% . DNA aneuploidy qualifies squamous intraepithelial lesions as high grade ( H-SIL ) which have to be treated whereas lack of DNA aneuploidy characterizes low grade squamous intraepithelial lesions ( L-SIL ) which have only to be controlled . The methodology is meanwhile internationally standardized concerning performance and diagnostic interpretation ."
],
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0,
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]
}
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[] |
[] |
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DerPathologe.90200034.eng.abstr
|
DerPathologe.90200034.eng.abstr
|
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"Diagnosis of cervical dysplasia is based on colposcopy , cytology and histology . In case of suspect cytology , the management ( controls only , extended diagnosis by histology or therapy without additional histological control ) is dependent on colposcopic findings . Biopsy or endocervical curettings are necessary in cases of suspect ectocervical findings or endocervical lesions , respectively . As a rule , HE staining is sufficient for histological diagnosis . Yet , additional prognostic information is obtained by HPV-analysis and DNA-cytometry . Grading of dysplasia should be done according to the most recent WHO/ISGYP criteria . The exact diagnosis as to the grading and extension of dysplasia is the prerequisite of an effective individually adjusted therapy . For ablative therapy , gynecologists have to focus their attention on modern organ preserving surgery strategies ( loop-excision ) ."
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[] |
[] |
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DerPathologe.90200042.eng.abstr
|
DerPathologe.90200042.eng.abstr
|
[
{
"id": "DerPathologe.90200042.eng.abstr-passage-0",
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"The clinical management of cervical carcinomas is solely based upon the FIGO-staging system . Therefore clinical staging is crucial for primary therapy of cervical carcinomas . Accurate morphologic evaluation of the surgical specimens completes the clinical staging and determines postoperative procedures and the individual prognosis . The most important morphologic prognostic factors include stromal invasion , vascular space involvement , tumor volume and surgical margins ( pelvic recurrence , metastasic dissemination , survival ) . The prognostic and therapeutic importance of tumor biological markers is presently controversial . Radical surgical therapy ( Wertheim-Meigs surgery ) and primary or adjuvant pelvic radiation are currently the basic therapeutic modalities for invasive cervical carcinomas . The role of chemotherapy still needs to be defined . A less radical therapeutic approach is performed for microinvasive cervical carcinomas depending on the extent of stromal invasion , the presence of vascular space involvement and the surgical margins ."
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[] |
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DerPathologe.90200050.eng.abstr
|
DerPathologe.90200050.eng.abstr
|
[
{
"id": "DerPathologe.90200050.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The ovarian steroid hormones estradiol and progesterone exert their effect by interacting with their intracellular receptors , which , after ligand binding translocate to the nucleus and bind to the promoter regions of target genes . The consequence is a change in the transcription rate of the target genes , followed by a change in production of the corresponding proteins . Target genes of the sexual steroid hormoness include cytokines and growth factors , among them CSF-1, TGF- and LIF . The rhythm and activity of steroidogenesis , receptor modulation and transcription are reflected by cycle-specific proliferation and differentiation processes in the endometrium . Quantitative and/or qualitative molecular endocrinology is of increasing interest for better definition of morphological changes , although , as yet , the pathological laboratory test is of much less practical consequence than a suspicious vaginal sonography . In spite of the high standard of ultrasound techniques , however , most cases with slightly increased endometrial thickness show histologically benign changes of the endometrium rather than endometrial precancer or cancer . This is especially true for perimenopausal women with no other clinical findings . Yet , the cancer risk is increased in women under tamoxifen therapy . Hence , as a rule , these cases , when endometrial thickness exceeds 5 mm , need a diagnostic biopsy or abrasio ."
],
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] |
[] |
[] |
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DerPathologe.90200056.eng.abstr
|
DerPathologe.90200056.eng.abstr
|
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"As to to their frequency and variety , endometrial meta- and hyperplasias are the most impressive examples of the growth and differentiation potential of the Muellerian system and the inductive power of steroid hormons and related inter- and intracellular factors . Characteristic steroid reactions are the glandular hyperplasias , ciliated and squamous cell metaplasias in the case of hyperestrogenism , and the mucinous and clear cell meta- and hyperplasias in the case of gestagen excess . In 1994 , the WHO established a new classification of endometrial hyperplasias . This classification takes into account the profound differences in cancer risk , and accordingly demands a clearcut distinction between simple and complex ( steroid sensitive , almost always reversible ) hyperplasias without atypia , and simple and complex ( partial steroid resistent and potential progressive ) hyperplasias with atypia . The conclusion drawn from clinical experience is , that the atypical endometrial hyperplasia - and this alone - is the precancerous lesion of the ordinary endometroid carcinoma . In contrast , it is still not clear which biological significance accounts to all the complex squamous , mucinous , clear cell and ciliated cell meta- and hyperplasias . Yet , it is good pathological and clinical practice , to upgrade any metaplastic lesion with nuclear atypia , and to remove the uterus as it is done in almost all atypical endometrial hyperplasias ."
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[] |
[] |
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DerPathologe.90200072.eng.abstr
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DerPathologe.90200072.eng.abstr
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"id": "DerPathologe.90200072.eng.abstr-passage-0",
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"text": [
"The clinico-pathologic characteristics and the histological/immunohistological differential diagnosis of villous trophoblastic lesions ( complete , partial , and invasive hydatiform moles ) , gestational choriocarcinoma and trophoblastic tumors and pseudotumors of the placental site ( placental-site trophoblastic tumor , exaggerated placental site reaction , placental site nodule ) are reviewed in context with aspects of cytogenetics , epidemiology and molecular pathogenesis ."
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[] |
[] |
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DerPathologe.90200098.eng.abstr
|
DerPathologe.90200098.eng.abstr
|
[
{
"id": "DerPathologe.90200098.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Until recently , benign cutaneous neural tumours which do not fulfil criteria for either neurofibrom or schwannoma often were lumped into the broad category of benign peripheral nerve sheath tumours ( PNST ) . However , during the last years a number of new entities of neural tumours have been described , and advances in immunohistochemistry and electronmicroscopy have helped us to better understand the cytological differentiation in these neoplasms . The knowledge of these distinctive neoplasms is necessary in order to avoid diagnostic pitfalls and misdiagnosis of more aggressive neoplasms . These distinctive lesions include : neurothekeoma , which can divided into classical myxoid and cellular types showing characteristic histological and immunohistochemical features . Typical neurothekeoma ( nerve sheath myxoma ) is a lobular or nodular dermal neoplasm composed of plump spindled or stellated , S-100 positive tumour cells set in a maxoid stroma . In contrast , cellular neurothekeoma is characterized as an ill-defined dermal neoplasm composed of concentric nests and fascicles of spindle-shaped and epitheloid tumour cells , which are S-100 negative but stain positively for NKIC3. The evidence of intermediate forms of neurothekeoma showing features of ordinary hypocellular neurothekeoma and cellular neurothekeoma , as well as ultrastructural studies , emphasize that both variants represent a spectrum of neurothekeoma ; solitary circumscribed neuroma ( \" palisaded encapsulated neuroma \" ) manifests mainly as a skin-colored or pink papule or nodule , and is most often located on the face . Histologically , solitary circumscribed neuroma is a well-circumscribed round or ovoid dermal neoplasm composed of interwoven fascicles of schwann cells , which stain positively for S-100 protein and numerous neurofilament positive axons surrounded partly by fibroblasts and EMA-positive perineurial cells ; perineurioma is a rare well-circumscribed neoplasm which occurs mainly in subcutaneous tissue and only rarely in the dermis and in deep soft tissues . Perineurioma is composed of elongated bipolar spindle-shaped tumour cells which are arranged in storiform , whorled , linear or lamellated growth patterns , The tumour cells stain positively for vimentin and EMA , and for CD 34 in a number of cases , but lack positivity for S-100 protein , neurofilament and desmoplakin . In addition unusual forms of schwannoma ( cellular schwannoma , solitary plexiform schwannoma , melanotic schwannoma ) and neurofibroma ( \" atypical \" ( bizarre ) neurofibroma , diffuse neurofibroma , epithelioid neurofibroma ) are briefly discussed ."
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DerPathologe.90200110.eng.abstr
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DerPathologe.90200110.eng.abstr
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[] |
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DerPathologe.90200115.eng.abstr
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DerPathologe.90200115.eng.abstr
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[] |
[] |
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DerPathologe.90200120.eng.abstr
|
DerPathologe.90200120.eng.abstr
|
[
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[] |
[] |
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DerPathologe.90200125.eng.abstr
|
DerPathologe.90200125.eng.abstr
|
[
{
"id": "DerPathologe.90200125.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A tumor was removed from the right external auditory canal of a 69-year old female patient . The histopathological and immunhistochemical evaluation revealed a pleomorphic adenoma ( mixed tumor ) . The differential diagnosis of the tumors derived from the ceruminal glands , their clinical and prognostic implications as well as the histogenesis of pleomorphic adenomas in this localization are discussed ."
],
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[
0,
406
]
]
}
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[] |
[] |
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DerPathologe.90200130.eng.abstr
|
DerPathologe.90200130.eng.abstr
|
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"In the biopsy material of a polypoid intrabronchial lesion of a 54-year-old male patient with radiologically established lung tumor , spindle-cell neoplasia was seen . No clear histogenetic classification of the submucous tumor process was possible . After resection of the right upper lobe of the lung , including the results of additional immunohistochemical analyses , the tumor was classified as biphasic synovial sarcoma . This was suggested mostly by immunohistochemical detection of the epithelial membrane antigene ( EMA ) and of vimentin . Extensive clinical examinations ruled out the possibility of a primary tumor with extrapulmonary localization . This case report shows the problems faced in correctly classifying the histogenesis or the direction of differentiation in extremely rare cases of primary pulmonary synovial sarcoma . Especially in small biopsy samples showing a submucous spindle-cell tumor of the lung , apart from frequent sarcoma metastases , the presence of primary synovial sarcoma of the lung has to be considered in the differential diagnosis ."
],
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DerPathologe.90200155.eng.abstr
|
DerPathologe.90200155.eng.abstr
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"id": "DerPathologe.90200155.eng.abstr-passage-0",
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"The rising numbers of tissue samples for securing a diagnosis has led to a multitude of tissue samples in pathology institutes . Criteria and measures for ensuring the quality of histological diagnosis have been developed . Corresponding rules for the organization of the tissue sampling up to their processing do not yet exist . Suspicion of interchanged samples occurs much more often than it actually happens ; however , it is important to be aware of the possibility so as to inform the clinician and to eliminate any possible causes of the confusion . The civil and penal consequences of such an interchanging , the subsequent \" incorrect \" diagnosis and the therapeutic measures are secondary compared to the potentially dramatic consequences for the patient . Important causes for an interchanging and possible preventive measures are presented ."
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[] |
[] |
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},
{
"id": "DerPathologe.90200155.eng.abstr-s2-r1-t1.1-t2.1",
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] |
DerPathologe.90200169.eng.abstr
|
DerPathologe.90200169.eng.abstr
|
[
{
"id": "DerPathologe.90200169.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A total of 70 malignant and 4 benign peritoneal mesotheliomas were diagnosed by the German Mesothelioma Registry between 1992 and 1998. Malignant mesotheliomas developed mainly in men ( 55/70 ) ; only one man had a benign peritoneal alteration . Age at first diagnosis of malignant mesotheliomas is about 59 years ; the women are on average 4 years younger than the men . Mean survival time ranges about 1 year ; in 6 of 38 patients longer survival times of up to 7 years are known . The epitheloid subtype predominates , but no effect on survival time is noticed . The percentage of patients with combined asbestos-associated lung fibrosis is higher than that for pleural mesotheliomas ; these patients become ill about 6.5 years earlier . The latency period is 36 years on average . For most patients asbestos exposure is related to their occupation mainly in metal industries , asbestos industries , and in the building trade . There is no evidence for an induction of benign peritoneal alterations by asbestos dust ."
],
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0,
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]
}
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DerPathologe.90200177.eng.abstr
|
DerPathologe.90200177.eng.abstr
|
[
{
"id": "DerPathologe.90200177.eng.abstr-passage-0",
"type": "abstract",
"text": [
"One rare case of so-called massive idiopathic osteolysis Gorham-Stout is presented . In a 77-year-old female patient the whole right femoral head and neck of femur was resorbed within 2.5 month following trauma . As a histologic cause for the osteolysis , a marked stimulation of osteoclasts on the spongiosa , especially intracortically , was observed . The course and the clinical findings are described , and the pathogenesis and treatment are discussed in comparison with the present literature . The results suggest that an early antiresorptive therapy ( calcitonin , bisphosphonates ) could stop the progressive osteolytic changes ."
],
"offsets": [
[
0,
638
]
]
}
] |
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DerPathologe.90200189.eng.abstr
|
DerPathologe.90200189.eng.abstr
|
[
{
"id": "DerPathologe.90200189.eng.abstr-passage-0",
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"text": [
"Multiple and bilateral oncocytomas are rare . There are only ten cases that have been previously described . Three of these displayed multiple and bilateral oncocytomas and microoncocytomas , a so-called oncocytomatosis . This report describes a case of renal oncocytomatosis found at autopsy . In addition , we found an adrenal adenoma , a pheochromocytoma and thoracic cicatrices 4 years after curatively resected large cell carcinoma of the lung . In the distal renal tubules we found oncocytic epithelial cells , with partial transition into microoncocytomas . Immunhistochemically , these and the main oncocytomas were CD 10 negative . These findings support the origin of oncocytoma from oncocytically transformed distal tubular epithelium . CGH analysis of the different tumors revealed no common cytogenetic changes . Coexistence of renal oncocytoma with other tumors is rare . Hitherto , coexistence of a renal oncocytomatosis with multiple tumors has not been described ."
],
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]
}
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DerPathologe.90200195.eng.abstr
|
DerPathologe.90200195.eng.abstr
|
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"We report on a patient who at 61 years of age presented with two nodular melanomas in the right nasal cavity . These tumors were limited to the mucosal membrane and were accompanied by a large amount of atypical hyperplasia of the melanocytes within the glandular and surface epithelium of various other samples of the mucous membrane , a finding also verified immunohistochemically . These tumors were treated surgically . In the clinical course , after a prolonged tumor-free interval , a malignant melanoma of the contralateral nasal cavity occurred , in addition to recurrences in the area of the primary tumor . It seems likely that the large , diffuse proliferation of atypical melanocytes observed could have been the starting point of both the tumor recurrences and the second primary . Thus , in a histologically proven melanoma in the mucous membranes of the upper respiratory system , a more intense preoperative histological diagnostic procedure , in given cases with the assistance of immunohistochemical methods , could be useful to demonstrate intraepithelial atypical melanocytes . It is possible that by doing this the present poor prognosis for mucosal melanomas of the upper respiratory tract might be improved ."
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DerPathologe.90200200.eng.abstr
|
DerPathologe.90200200.eng.abstr
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"id": "DerPathologe.90200200.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The 100-year-history of Pathological Anatomy in Chemnitz is described by edification and fall of its buildings as well as the main dates of its leaders . From these the founder of the institute Coelestin Nauwerck , his most important disciple Martin Staemmler and the newfounder after the 2nd world war Walther Panofsky are especially mentioned . The article also refers to the involvement of Staemmler in Nazism and the injury done to Panofsky by it . The importance of the microbiological-hygienical departure during a long period is accented ."
],
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0,
546
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}
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[] |
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DerPathologe.90200217.eng.abstr
|
DerPathologe.90200217.eng.abstr
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"This article describes the historical development of the grading systems for malignant soft tissue tumors . The first attempts to grade these tumors were made in the middle of the nineteen century ; a remarkable amount of activity in grading took place in the 1970s which reached a maximum in the 1980s . Reviewing the literature back to the first available publications , five phases in the development of the grading systems for malignant soft tissue tumors could be distinguished . Five commonly used systems were checked for comparing and handling of 339 patients with malignant soft tissue tumors . The use of two multifactorial systems , one simple and one complex , to grade malignant soft tissue tumors should be favored ."
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0,
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] |
[] |
[] |
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},
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"type": "location_of",
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},
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"id": "DerPathologe.90200217.eng.abstr-s5-r3-t1.1-t4.1",
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"arg2_id": "DerPathologe.90200217.eng.abstr-s5-t4",
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}
] |
DerPathologe.90200224.eng.abstr
|
DerPathologe.90200224.eng.abstr
|
[
{
"id": "DerPathologe.90200224.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Chondromyxoid fibroma is a rare benign bone tumor , accounting for less than 1% of all bone tumors . The peak age incidence is the second and third decade of life . Chondromyxoid fibrom occurs in the metaphyseal parts of the major tubular bones , predominantly of the lower extremity . Roentgenograms show , in most cases , a well-demarcated radiolucent lesion . The classic histological feature of a chondromyxoid fibroma is stellate or spindle-shaped cells arranged in lobules in a myxoid or chondroid background . Analysis of 40 chondromyxoid fibromas demonstrates the morphological variation of this tumor . Cases were examined for age distribution , localization , and radiological and histological features . In 85% we found the typical histomorphological pattern . Recurrence rate was 12.5% . In four cases the appearance was uncharacteristic and differentiation from other tumors such as chondroblastoma or chondrosarcoma was quite difficult . By adhering to strict histomorphological criteria , definite diagnosis of chondromyxoid fibroma can be made in most cases ."
],
"offsets": [
[
0,
1075
]
]
}
] |
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14,
21
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{
"id": "DerPathologe.90200224.eng.abstr-s1-t2",
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"text": [
"bone"
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{
"id": "DerPathologe.90200224.eng.abstr-s1-t3",
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"text": [
"tumor"
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44,
49
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"bone"
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"tumors"
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"id": "DerPathologe.90200224.eng.abstr-s1-t6",
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"bone tumor"
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"age"
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"id": "DerPathologe.90200224.eng.abstr-s2-t2",
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"incidence"
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]
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{
"id": "DerPathologe.90200224.eng.abstr-s2-t3",
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"life"
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"id": "DerPathologe.90200224.eng.abstr-s3-t1",
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},
{
"id": "DerPathologe.90200224.eng.abstr-s3-t2",
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"text": [
"extremity"
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},
{
"id": "DerPathologe.90200224.eng.abstr-s3-t3",
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"text": [
"lower extremity"
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"id": "DerPathologe.90200224.eng.abstr-s4-t1",
"type": "umlsterm",
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"Roentgenograms"
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"id": "DerPathologe.90200224.eng.abstr-s5-t1",
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{
"id": "DerPathologe.90200224.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"cells"
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"Analysis"
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{
"id": "DerPathologe.90200224.eng.abstr-s6-t2",
"type": "umlsterm",
"text": [
"fibromas"
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},
{
"id": "DerPathologe.90200224.eng.abstr-s6-t3",
"type": "umlsterm",
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"morphological"
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"variation"
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"age"
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{
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"distribution"
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"age distribution"
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"id": "DerPathologe.90200224.eng.abstr-s9-t1",
"type": "umlsterm",
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"Recurrence"
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"id": "DerPathologe.90200224.eng.abstr-s10-t1",
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},
{
"id": "DerPathologe.90200224.eng.abstr-s10-t2",
"type": "umlsterm",
"text": [
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},
{
"id": "DerPathologe.90200224.eng.abstr-s10-t3",
"type": "umlsterm",
"text": [
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{
"id": "DerPathologe.90200224.eng.abstr-s11-t1",
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"text": [
"criteria"
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{
"id": "DerPathologe.90200224.eng.abstr-s11-t2",
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"text": [
"diagnosis"
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]
},
{
"id": "DerPathologe.90200224.eng.abstr-s11-t3",
"type": "umlsterm",
"text": [
"fibroma"
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{
"db_name": "UMLS",
"db_id": "C0016045"
}
]
}
] |
[] |
[] |
[
{
"id": "DerPathologe.90200224.eng.abstr-s2-r1-t1.2-t1.1",
"type": "produces",
"arg1_id": "DerPathologe.90200224.eng.abstr-s7-t1",
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"normalized": []
},
{
"id": "DerPathologe.90200224.eng.abstr-s2-r2-t2.1-t1.2",
"type": "measurement_of",
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"arg2_id": "DerPathologe.90200224.eng.abstr-s7-t1",
"normalized": []
},
{
"id": "DerPathologe.90200224.eng.abstr-s2-r3-t1.2-t3.1",
"type": "isa",
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},
{
"id": "DerPathologe.90200224.eng.abstr-s2-r4-t1.1-t2.1",
"type": "uses",
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"arg2_id": "DerPathologe.90200224.eng.abstr-s11-t2",
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{
"id": "DerPathologe.90200224.eng.abstr-s2-r5-t2.1-t3.1",
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},
{
"id": "DerPathologe.90200224.eng.abstr-s3-r1-t1.1-t3.1",
"type": "adjacent_to",
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DerPathologe.90200236.eng.abstr
|
DerPathologe.90200236.eng.abstr
|
[
{
"id": "DerPathologe.90200236.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Squamous cell carcinoma as a late complication of chronic osteomyelitis is a well known phenomenon in traumatology , often occurring as a consequence of bone fractures . The majority of cases are observed in men between 50 and 60 years of age . The time from onset of inflammatory bone disease to malignant transformation differs but usually takes 30 years . In general , prognosis is thought to be favorable when adequate surgical therapy is carried out . Nowadays , it is important to recall this condition , because it has become rare . The cases reported here illustrate the difficulties that may be encountered in diagnosing malignant transformation , especially in lesions that develop in deep tissue layers and which may be responsible for various biopsies failing to reveal the true pathology ."
],
"offsets": [
[
0,
802
]
]
}
] |
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[] |
[] |
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DerPathologe.90200288.eng.abstr
|
DerPathologe.90200288.eng.abstr
|
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{
"id": "DerPathologe.90200288.eng.abstr-passage-0",
"type": "abstract",
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"Tyrosine-rich crystalloids in tumors of the salivary glands are rare and have been reported mainly in specimens from Black African patients . The pathogenesis of these structures is still unclear , but pathological secretion by neoplastic myoepithelial cells is supposed . Millon's staining and ultrastructural examinations are used for confirming the diagnosis . We present the case report of a 59-year-old woman with a myoepithelioma of the minor salivary glands in the smooth palate containing tyrosine-rich crystalloids as an example of this rare phenomenon ."
],
"offsets": [
[
0,
563
]
]
}
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{
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{
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] |
[] |
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DerPathologe.90200297.eng.abstr
|
DerPathologe.90200297.eng.abstr
|
[
{
"id": "DerPathologe.90200297.eng.abstr-passage-0",
"type": "abstract",
"text": [
"Additions and use of an epidiascope are described , which may be used after minor modifications for presenting wohle organs and organ slices in lectures on general and systemic pathology , saving the installation of sophisticated video equipment with additional lighting etc."
],
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0,
275
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]
}
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"id": "DerPathologe.90200297.eng.abstr-s1-t5",
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[] |
[] |
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DerPathologe.90200321.eng.abstr
|
DerPathologe.90200321.eng.abstr
|
[
{
"id": "DerPathologe.90200321.eng.abstr-passage-0",
"type": "abstract",
"text": [
"DNA-cytophotometry is one of the methods that may contribute to a more precise evaluation of the biological behaviour of tumours in addition to the WHO-classification . In this study 121 tumour specimens of 50 patients suffering from gliomas with one or up to three recurrencies were investigated . In all cases the histological type and WHO-grade and the Ki-67/MIB1 labeling index were determined . DNA cytophotometry was performed after single cell preparation on Feulgen-stained preparations , and the following parameters were calculated : stemline ploidy , 5c-exceeding rate , and 2c-deviation index ."
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0,
606
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]
}
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[] |
[] |
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"id": "DerPathologe.90200321.eng.abstr-s4-r5-t3.1-t6.1",
"type": "performs",
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"arg2_id": "DerPathologe.90200321.eng.abstr-s4-t6",
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},
{
"id": "DerPathologe.90200321.eng.abstr-s4-r6-t1.1-t3.1",
"type": "disrupts",
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"arg2_id": "DerPathologe.90200321.eng.abstr-s4-t3",
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},
{
"id": "DerPathologe.90200321.eng.abstr-s4-r7-t3.1-t2.1",
"type": "performs",
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},
{
"id": "DerPathologe.90200321.eng.abstr-s4-r8-t2.1-t5.1",
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"arg2_id": "DerPathologe.90200321.eng.abstr-s4-t5",
"normalized": []
}
] |
DerPathologe.90200335.eng.abstr
|
DerPathologe.90200335.eng.abstr
|
[
{
"id": "DerPathologe.90200335.eng.abstr-passage-0",
"type": "abstract",
"text": [
"A meningioma with cartilaginous areas is described . The tumour arose in the region of the right sphenoid wing in a 74-year-old woman . Histologically , it showed large areas of a typical meningothelial meningioma , among which numerous cartilaginous islands and some chondroid regions , obviously of intermediate ( meningothelial/cartilaginous ) differentiation , could be seen . Cartilaginous tumour areas showed lower MIB1-labelling indices than typical meningioma regions , where an increased proliferative activity was seen focally . The current WHO classification lists such tumours as metaplastic meningiomas , reflecting the potential of meningioma cells for mesenchymal differentiation . Metaplastic meningiomas may show different metaplasias ( xanthomatous , osseous , lipomatous , cartilaginous , etc. ) . Extensive cartilaginous metaplasias are very uncommon . Identification of typical meningioma areas is the key for the diagnosis of this meningioma variant ."
],
"offsets": [
[
0,
973
]
]
}
] |
[
{
"id": "DerPathologe.90200335.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"meningioma"
],
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[
2,
12
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0025286"
}
]
},
{
"id": "DerPathologe.90200335.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"tumour"
],
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[
57,
63
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0027651"
}
]
},
{
"id": "DerPathologe.90200335.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"right"
],
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[
91,
96
]
],
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{
"db_name": "UMLS",
"db_id": "C0035621"
}
]
},
{
"id": "DerPathologe.90200335.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"wing"
],
"offsets": [
[
106,
110
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0043189"
}
]
},
{
"id": "DerPathologe.90200335.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"woman"
],
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128,
133
]
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{
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"db_id": "C0043210"
}
]
},
{
"id": "DerPathologe.90200335.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"meningioma"
],
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203,
213
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],
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"db_name": "UMLS",
"db_id": "C0025286"
}
]
},
{
"id": "DerPathologe.90200335.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"islands"
],
"offsets": [
[
251,
258
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0022130"
}
]
},
{
"id": "DerPathologe.90200335.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"tumour"
],
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[
395,
401
]
],
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"db_name": "UMLS",
"db_id": "C0027651"
}
]
},
{
"id": "DerPathologe.90200335.eng.abstr-s4-t2",
"type": "umlsterm",
"text": [
"indices"
],
"offsets": [
[
436,
443
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0021200"
},
{
"db_name": "UMLS",
"db_id": "C0918012"
}
]
},
{
"id": "DerPathologe.90200335.eng.abstr-s4-t3",
"type": "umlsterm",
"text": [
"meningioma"
],
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457,
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],
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}
]
},
{
"id": "DerPathologe.90200335.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"classification"
],
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},
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}
]
},
{
"id": "DerPathologe.90200335.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"tumours"
],
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581,
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]
],
"normalized": [
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}
]
},
{
"id": "DerPathologe.90200335.eng.abstr-s5-t3",
"type": "umlsterm",
"text": [
"meningiomas"
],
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604,
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]
],
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}
]
},
{
"id": "DerPathologe.90200335.eng.abstr-s5-t4",
"type": "umlsterm",
"text": [
"meningioma"
],
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646,
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}
]
},
{
"id": "DerPathologe.90200335.eng.abstr-s5-t5",
"type": "umlsterm",
"text": [
"cells"
],
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[
657,
662
]
],
"normalized": [
{
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"db_id": "C0007634"
}
]
},
{
"id": "DerPathologe.90200335.eng.abstr-s6-t1",
"type": "umlsterm",
"text": [
"meningiomas"
],
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709,
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],
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"db_id": "C0025286"
}
]
},
{
"id": "DerPathologe.90200335.eng.abstr-s8-t1",
"type": "umlsterm",
"text": [
"Identification"
],
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[
873,
887
]
],
"normalized": [
{
"db_name": "UMLS",
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]
},
{
"id": "DerPathologe.90200335.eng.abstr-s8-t2",
"type": "umlsterm",
"text": [
"meningioma"
],
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899,
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}
]
},
{
"id": "DerPathologe.90200335.eng.abstr-s8-t3",
"type": "umlsterm",
"text": [
"diagnosis"
],
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935,
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]
],
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"db_name": "UMLS",
"db_id": "C0011900"
},
{
"db_name": "UMLS",
"db_id": "C0348026"
}
]
},
{
"id": "DerPathologe.90200335.eng.abstr-s8-t4",
"type": "umlsterm",
"text": [
"meningioma"
],
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[
953,
963
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0025286"
}
]
}
] |
[] |
[] |
[
{
"id": "DerPathologe.90200335.eng.abstr-s2-r1-t4.1-t1.1",
"type": "associated_with",
"arg1_id": "DerPathologe.90200335.eng.abstr-s8-t4",
"arg2_id": "DerPathologe.90200335.eng.abstr-s8-t1",
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},
{
"id": "DerPathologe.90200335.eng.abstr-s2-r2-t1.1-t4.1",
"type": "associated_with",
"arg1_id": "DerPathologe.90200335.eng.abstr-s8-t1",
"arg2_id": "DerPathologe.90200335.eng.abstr-s8-t4",
"normalized": []
},
{
"id": "DerPathologe.90200335.eng.abstr-s2-r3-t2.1-t1.1",
"type": "location_of",
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},
{
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},
{
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"arg2_id": "DerPathologe.90200335.eng.abstr-s8-t2",
"normalized": []
},
{
"id": "DerPathologe.90200335.eng.abstr-s4-r1-t2.1-t1.1",
"type": "associated_with",
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"arg2_id": "DerPathologe.90200335.eng.abstr-s8-t1",
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},
{
"id": "DerPathologe.90200335.eng.abstr-s4-r2-t1.1-t2.1",
"type": "associated_with",
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"arg2_id": "DerPathologe.90200335.eng.abstr-s8-t2",
"normalized": []
},
{
"id": "DerPathologe.90200335.eng.abstr-s5-r1-t5.1-t4.1",
"type": "location_of",
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"arg2_id": "DerPathologe.90200335.eng.abstr-s8-t4",
"normalized": []
},
{
"id": "DerPathologe.90200335.eng.abstr-s5-r2-t5.1-t1.2",
"type": "location_of",
"arg1_id": "DerPathologe.90200335.eng.abstr-s5-t5",
"arg2_id": "DerPathologe.90200335.eng.abstr-s5-t1",
"normalized": []
},
{
"id": "DerPathologe.90200335.eng.abstr-s5-r3-t5.1-t3.1",
"type": "location_of",
"arg1_id": "DerPathologe.90200335.eng.abstr-s5-t5",
"arg2_id": "DerPathologe.90200335.eng.abstr-s8-t3",
"normalized": []
},
{
"id": "DerPathologe.90200335.eng.abstr-s8-r1-t3.2-t1.1",
"type": "result_of",
"arg1_id": "DerPathologe.90200335.eng.abstr-s8-t3",
"arg2_id": "DerPathologe.90200335.eng.abstr-s8-t1",
"normalized": []
},
{
"id": "DerPathologe.90200335.eng.abstr-s8-r2-t3.1-t2.1",
"type": "associated_with",
"arg1_id": "DerPathologe.90200335.eng.abstr-s8-t3",
"arg2_id": "DerPathologe.90200335.eng.abstr-s8-t2",
"normalized": []
},
{
"id": "DerPathologe.90200335.eng.abstr-s8-r3-t3.1-t1.1",
"type": "measures",
"arg1_id": "DerPathologe.90200335.eng.abstr-s8-t3",
"arg2_id": "DerPathologe.90200335.eng.abstr-s8-t1",
"normalized": []
},
{
"id": "DerPathologe.90200335.eng.abstr-s8-r4-t2.1-t3.1",
"type": "associated_with",
"arg1_id": "DerPathologe.90200335.eng.abstr-s8-t2",
"arg2_id": "DerPathologe.90200335.eng.abstr-s8-t3",
"normalized": []
},
{
"id": "DerPathologe.90200335.eng.abstr-s8-r5-t2.1-t1.1",
"type": "result_of",
"arg1_id": "DerPathologe.90200335.eng.abstr-s8-t2",
"arg2_id": "DerPathologe.90200335.eng.abstr-s8-t1",
"normalized": []
},
{
"id": "DerPathologe.90200335.eng.abstr-s8-r6-t1.1-t3.2",
"type": "result_of",
"arg1_id": "DerPathologe.90200335.eng.abstr-s8-t1",
"arg2_id": "DerPathologe.90200335.eng.abstr-s8-t3",
"normalized": []
},
{
"id": "DerPathologe.90200335.eng.abstr-s8-r8-t1.1-t2.1",
"type": "result_of",
"arg1_id": "DerPathologe.90200335.eng.abstr-s8-t1",
"arg2_id": "DerPathologe.90200335.eng.abstr-s8-t2",
"normalized": []
}
] |
DerPathologe.90200340.eng.abstr
|
DerPathologe.90200340.eng.abstr
|
[
{
"id": "DerPathologe.90200340.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report on the case of a 45-years old woman with repeated pleural effusions lasting for 2 years . She had a history of breast carcinoma 6 years ago , which was treated by breast amputation and radiation . After repeated histological and cytological examinations no tumorous compromise of the pleura or other cause for the effussions could be found . A pleural resection was performed . On the histological and electron microscopical examination deposits of a foreign substance were found , which was identified as polyvinylpyrrolidone . This substance was obviously introduced in the pleural cavity by the attempts to treat the effussions by pleurodesis with Diclofenac and Tetracyclin ( Vibravenoes ) . The diagnosis is suggested by the histological findings , but it must be confirmed by anamnesis , also for PVP deposits in other organs ."
],
"offsets": [
[
0,
843
]
]
}
] |
[
{
"id": "DerPathologe.90200340.eng.abstr-s1-t1",
"type": "umlsterm",
"text": [
"old"
],
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36,
39
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0331059"
}
]
},
{
"id": "DerPathologe.90200340.eng.abstr-s1-t2",
"type": "umlsterm",
"text": [
"woman"
],
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[
40,
45
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0043210"
}
]
},
{
"id": "DerPathologe.90200340.eng.abstr-s1-t3",
"type": "umlsterm",
"text": [
"pleural"
],
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[
60,
67
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0032226"
}
]
},
{
"id": "DerPathologe.90200340.eng.abstr-s1-t4",
"type": "umlsterm",
"text": [
"pleural effusions"
],
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[
60,
77
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0032227"
}
]
},
{
"id": "DerPathologe.90200340.eng.abstr-s2-t1",
"type": "umlsterm",
"text": [
"history"
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110,
117
]
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"db_id": "C0019664"
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{
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"db_id": "C0019665"
}
]
},
{
"id": "DerPathologe.90200340.eng.abstr-s2-t2",
"type": "umlsterm",
"text": [
"breast"
],
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121,
127
]
],
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"db_id": "C0006141"
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"db_id": "C0006142"
}
]
},
{
"id": "DerPathologe.90200340.eng.abstr-s2-t3",
"type": "umlsterm",
"text": [
"carcinoma"
],
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128,
137
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],
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"db_id": "C0007097"
}
]
},
{
"id": "DerPathologe.90200340.eng.abstr-s2-t4",
"type": "umlsterm",
"text": [
"breast"
],
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[
173,
179
]
],
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{
"db_name": "UMLS",
"db_id": "C0006141"
},
{
"db_name": "UMLS",
"db_id": "C0006142"
}
]
},
{
"id": "DerPathologe.90200340.eng.abstr-s2-t5",
"type": "umlsterm",
"text": [
"amputation"
],
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[
180,
190
]
],
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{
"db_name": "UMLS",
"db_id": "C0002688"
}
]
},
{
"id": "DerPathologe.90200340.eng.abstr-s2-t6",
"type": "umlsterm",
"text": [
"radiation"
],
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[
195,
204
]
],
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{
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"db_id": "C0851346"
}
]
},
{
"id": "DerPathologe.90200340.eng.abstr-s3-t1",
"type": "umlsterm",
"text": [
"pleura"
],
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[
294,
300
]
],
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{
"db_name": "UMLS",
"db_id": "C0032225"
}
]
},
{
"id": "DerPathologe.90200340.eng.abstr-s3-t2",
"type": "umlsterm",
"text": [
"cause"
],
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[
310,
315
]
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"db_id": "C0015127"
}
]
},
{
"id": "DerPathologe.90200340.eng.abstr-s4-t1",
"type": "umlsterm",
"text": [
"pleural"
],
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354,
361
]
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{
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"db_id": "C0032226"
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]
},
{
"id": "DerPathologe.90200340.eng.abstr-s5-t1",
"type": "umlsterm",
"text": [
"electron"
],
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[
412,
420
]
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{
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"db_id": "C0013852"
}
]
},
{
"id": "DerPathologe.90200340.eng.abstr-s5-t2",
"type": "umlsterm",
"text": [
"polyvinylpyrrolidone"
],
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[
516,
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],
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{
"db_name": "UMLS",
"db_id": "C0032856"
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]
},
{
"id": "DerPathologe.90200340.eng.abstr-s6-t1",
"type": "umlsterm",
"text": [
"pleural"
],
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[
586,
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]
],
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{
"db_name": "UMLS",
"db_id": "C0032226"
}
]
},
{
"id": "DerPathologe.90200340.eng.abstr-s6-t2",
"type": "umlsterm",
"text": [
"pleurodesis"
],
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[
644,
655
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0032225"
}
]
},
{
"id": "DerPathologe.90200340.eng.abstr-s6-t3",
"type": "umlsterm",
"text": [
"pleurodesis"
],
"offsets": [
[
644,
655
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0284292"
}
]
},
{
"id": "DerPathologe.90200340.eng.abstr-s6-t4",
"type": "umlsterm",
"text": [
"pleurodesis"
],
"offsets": [
[
644,
655
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0751995"
}
]
},
{
"id": "DerPathologe.90200340.eng.abstr-s6-t5",
"type": "umlsterm",
"text": [
"Diclofenac"
],
"offsets": [
[
661,
671
]
],
"normalized": [
{
"db_name": "UMLS",
"db_id": "C0012091"
}
]
},
{
"id": "DerPathologe.90200340.eng.abstr-s6-t6",
"type": "umlsterm",
"text": [
"Tetracyclin"
],
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DerPathologe.90200345.eng.abstr
|
DerPathologe.90200345.eng.abstr
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"text": [
"We report on a 12-year old boy suffering from malignant epithelioid hemangioendothelioma of the liver , which is a very rare tumor in childhood . The tumor was detected by ultrasound examination at the age of 10 and appeared at that time as a solitary intrahepatic nodular lesion . During the following 2 years multiple nodular lesions developed in both hepatic lobes . There were neither any suspect anamnestic findings nor abnormal clinical or laboratory data . The tumor showed the typical histomorphological , immunohistochemical , and ultrastructural features of this entity , which is usually seen in older patients . We investigated proliferative activity , apoptotic regulation , and expression of VEGF and VEGF-receptor flk-1 by means of immunohistochemical techniques . According to the known slow growth activity of these tumors we found only a few Ki-67 positive tumor cells . We did not detect any apoptotic cells using TUNEL technique . The positive immunoreaction of the tumor cells with antibodies against VEGF and VEGF-receptor flk-1 may indicate the regulation of tumor growth by angiogenetic factors . We present our findings together with a summary of the most important publications of recent years concerning these tumors ."
],
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DerPathologe.90200351.eng.abstr
|
DerPathologe.90200351.eng.abstr
|
[
{
"id": "DerPathologe.90200351.eng.abstr-passage-0",
"type": "abstract",
"text": [
"We report on a 62-year-old female patient with melena in which polypoid lesions of the cecum were discovered endoscopically . Histological examination of mucosal biopsies revealed an inflammatory process with lots of histiocytes and so-called Michaelis-Gutmann bodies , leading to the diagnosis of a malakoplakia of the colon . No other organs were found affected . In the course of an antibiotic therapy , there was no melena detectable over a period of six months . Malakoplakia , an inflammation usually affecting the urogenital tract , is rarely found in the colon , with only 35 cases published until now . It is frequently associated with other diseases like neoplastic or inflammatory disorders , immune defect syndromes or heroin abuse . This spectrum is expanded by our report in which a long-standing alcohol abuse was found as an attendant disease ."
],
"offsets": [
[
0,
860
]
]
}
] |
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{
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{
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{
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"cecum"
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"id": "DerPathologe.90200351.eng.abstr-s2-t5",
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"colon"
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"id": "DerPathologe.90200351.eng.abstr-s5-t1",
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[] |
[] |
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] |
DerPathologe.90200355.eng.abstr
|
DerPathologe.90200355.eng.abstr
|
[
{
"id": "DerPathologe.90200355.eng.abstr-passage-0",
"type": "abstract",
"text": [
"The occurrence of pregnancy-associated ectopic decidua is a well-documented phenomenon . It has been observed most often in the ovaries , uterus , and cervix . An extragenital localization is less frequent and usually an asymptomatic , incidental finding ."
],
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0,
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]
}
] |
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{
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{
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] |
[] |
[] |
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DerPathologe.90200365.eng.abstr
|
DerPathologe.90200365.eng.abstr
|
[
{
"id": "DerPathologe.90200365.eng.abstr-passage-0",
"type": "abstract",
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],
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0,
755
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]
}
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"id": "DerPathologe.90200365.eng.abstr-s2-t3",
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] |
[] |
[] |
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DerRadiologe.00400002.eng.abstr
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DerRadiologe.00400002.eng.abstr
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] |
[] |
[] |
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}
] |
DerRadiologe.00400008.eng.abstr
|
DerRadiologe.00400008.eng.abstr
|
[
{
"id": "DerRadiologe.00400008.eng.abstr-passage-0",
"type": "abstract",
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],
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0,
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]
}
] |
[
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[] |
[] |
[
{
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DerRadiologe.00400018.eng.abstr
|
DerRadiologe.00400018.eng.abstr
|
[
{
"id": "DerRadiologe.00400018.eng.abstr-passage-0",
"type": "abstract",
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"Magnetic resonance tomography ( MRT ) has become the most important method in the workup of infantile cerebral complications after primary sonography . Cerebral MR examination and image interpretation during the infantile period require extensive knowledge of morphological manifestations , their pathophysiological background , and frequency . The choice of imaging parameters and image interpretation is demonstrated in infarctions and hemorrhages of the mature and immature brain . A review of the main differential diagnoses is also given . The relevance of MR spectroscopy and fetal MRI is discussed ."
],
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]
}
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[
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}
] |
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