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Social play is critical for the development of prefrontal inhibitory synapses and cognitive flexibility in rats
|
neuroscience
|
Serotonergic psychedelic drugs LSD and psilocybin reduce the hierarchical differentiation of unimodal and transmodal cortex
|
neuroscience
|
Virtual Mouse Brain Histology from Multi-contrast MRI via Deep Learning
|
bioengineering
|
Network analysis reveals different strategies of Trichoderma spp. associated with XYR1 and CRE1 during cellulose degradation
|
bioinformatics
|
Iron Responsive Element (IRE)-mediated responses to iron dyshomeostasis in Alzheimer's disease
|
bioinformatics
|
Gliding motility of Plasmodium merozoites
|
microbiology
|
The microbiota promotes social behavior by modulating microglial remodeling of forebrain neurons
|
neuroscience
|
Identification of synaptic PPT1 substrates highlight roles of depalmitoylation in disulfide bond formation and synaptic function
|
neuroscience
|
Estimating RNA dynamics using one time point for one sample in a single-pulse metabolic experiment
|
bioinformatics
|
Precise optical control of gene expression in C. elegans using genetic code expansion and Cre recombinase
|
neuroscience
|
Inside-out regulation of E-cadherin conformation and adhesion
|
biophysics
|
Sequestration of the exocytic SNARE Psy1 into multiprotein nodes reinforces polarized morphogenesis in fission yeast
|
cell biology
|
Closed-loop sacral neuromodulation for bladder function using dorsal root ganglia sensory feedback in an acute feline model
|
bioengineering
|
Obesity-induced astrocyte dysfunction impairs heterosynaptic plasticity in the orbitofrontal cortex.
|
neuroscience
|
Principal component analysis revealed multiple consistent responses to naturalistic stimuli in children and adults
|
neuroscience
|
Evolution is exponentially more powerful with frequency-dependent selection
|
evolutionary biology
|
Widespread misregulation of inter-species hybrid transcriptomes due to sex-specific and sex-chromosome regulatory evolution
|
genomics
|
Mechanistic insights into RNA binding and RNA-regulated RIG-I ubiquitination by TRIM25
|
molecular biology
|
A functional genetic toolbox for human tissue-derived organoids
|
developmental biology
|
Robust Inference of Kinase Activity using Functional Networks
|
systems biology
|
A convolutional neural network for estimating synaptic connectivity from spike trains
|
neuroscience
|
Dopamine firing plays a double role in coding reward prediction errors and signaling motivation in a working memory task.
|
neuroscience
|
Independent and Interacting Value Systems for Reward and Information in the Human Brain
|
neuroscience
|
Novel strategies of Raman imaging for monitoring intracellular retinoid metabolism in cancer cells
|
cancer biology
|
Epigenetic modulation reveals differentiation state specificity of oncogene addiction
|
systems biology
|
Data-driven learning how oncogenic gene expression locally alters heterocellular networks
|
systems biology
|
Nothing better to do? Environment quality and the evolution of cooperation by partner choice
|
evolutionary biology
|
Heritable functional architecture in human visual cortex
|
neuroscience
|
The paraventricular thalamus provides a polysynaptic brake on limbic CRF neurons to sex-dependently blunt binge alcohol drinking and avoidance behavior
|
neuroscience
|
Subfunctionalization of paralog transcription factors contributes to regulation of alkaloid pathway branch choice in Catharanthus roseus
|
plant biology
|
Delta-range coupling between prefrontal cortex and hippocampus supported by respiratory rhythmic input from the olfactory bulb
|
neuroscience
|
Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia
|
cancer biology
|
A first perturbome of Pseudomonas aeruginosa: Identification of core genes related to multiple perturbations by a machine learning approach
|
bioinformatics
|
Myosin-X and talin modulate integrin activity at filopodia tips
|
cell biology
|
A comprehensive portrait of antimicrobial resistance in the zoonotic pathogen Streptococcus suis
|
microbiology
|
Delay of gratification in non-human animals: A review of inter-specific variation in performance
|
animal behavior and cognition
|
Conserved long-range base pairings associated with pre-mRNA processing of human protein-coding genes
|
bioinformatics
|
Sampling bias exaggerates a textbook example of a trophic cascade
|
ecology
|
Integrated neural dynamics for behavioral decisions and attentional control in the prefrontal cortex
|
neuroscience
|
Bayesian combination of mechanistic modeling and machine learning (BaM3): improving personalized tumor growth predictions
|
bioinformatics
|
Independent somatic evolution underlies clustered neuroendocrine tumors in the human small intestine
|
genomics
|
The Impact of Graph Construction Scheme and Community Detection Algorithm on the Reliability of Community and Hub Identification in Structural Brain Networks
|
neuroscience
|
Cancer phylogenetic tree inference at scale from 1000s of single cell genomes
|
bioinformatics
|
Optimizing experimental design for genome sequencing and assembly with Oxford Nanopore Technologies
|
genomics
|
The changes in the p53 protein across the animal kingdom pointing to its involvement in longevity
|
bioinformatics
|
Identification of 370 genetic loci for age at first sex and birth linked to externalising behaviour
|
genetics
|
Development of a vaccine against the newly emerging COVID-19 virus based on the receptor binding domain displayed on virus-like particles
|
immunology
|
Reclassification of seven honey bee symbiont strains as Bombella apis
|
microbiology
|
Coding and regulatory variants affect serum protein levels and common disease
|
genetics
|
Neural Correlates of Value Are Intrinsically History Dependent
|
neuroscience
|
A combination of mRNA features influence the efficiency of leaderless mRNA translation initiation
|
systems biology
|
Temporal correlation between oscillating force dipoles drives 3D single cell migration
|
biophysics
|
A Phylogenetic Approach to Inferring the Order in Which Mutations Arise during Cancer Progression
|
cancer biology
|
Causal Inference for Heritable Phenotypic Risk Factors Using Heterogeneous Genetic Instruments
|
genetics
|
A hybrid open-top light-sheet microscope for multi-scale imaging of cleared tissues
|
bioengineering
|
Restricted maximum-likelihood method for learning latent variance components in gene expression data with known and unknown confounders
|
bioinformatics
|
Virome composition in marine fish revealed by meta-transcriptomics
|
microbiology
|
Evolution and genetic basis of the plant-penetrating ovipositor, a key adaptation in the transition to herbivory within the Drosophilidae
|
evolutionary biology
|
Screening for Potential Interaction Partners with Surface Plasmon Resonance Imaging Coupled to MALDI Mass Spectrometry
|
molecular biology
|
A metabolic CRISPR-Cas9 screen in Chinese hamster ovary cells identifies glutamine-sensitive genes
|
bioengineering
|
Cast away on Mindoro island: population dynamics of the critically endangered tamaraw (Bubalus mindorensis) at Mounts Iglit-Baco Natural Park
|
ecology
|
Microbial helpers allow cyanobacteria to thrive in ferruginous waters
|
microbiology
|
The phylogenetic and global distribution of bacterial polyhydroxyalkanoate bioplastic degrading genes
|
microbiology
|
Condensation of pericentrin proteins in human cells illuminates phase separation in centrosome assembly
|
cell biology
|
Differential neural circuitry behind autism subtypes with imbalanced social-communicative and restricted repetitive behavior symptoms
|
neuroscience
|
E2F4 as a single multifactorial target against Alzheimer's disease
|
pathology
|
Explainable multi-view framework for dissecting inter-cellular signaling from highly multiplexed spatial data
|
systems biology
|
Whole-brain modelling of resting state fMRI differentiates ADHD subtypes and facilitates stratified neuro-stimulation therapy
|
neuroscience
|
Design issues and solutions for stop-signal data from the Adolescent Brain Cognitive Development study
|
neuroscience
|
Polishing Copy Number Variant Calls on Exome Sequencing Data via Deep Learning
|
bioinformatics
|
Measuring context dependency in birdsong using artificial neural networks
|
animal behavior and cognition
|
Heparan sulfate proteoglycans as attachment factor for SARS-CoV-2
|
biochemistry
|
Prolonged impacts of past agriculture and overgrazing on soil fungal communities in restored forests
|
ecology
|
The role of high cholesterol in age related COVID19 lethality.
|
cell biology
|
SARS-CoV-2 Spike Glycoprotein and ACE2 interaction reveals modulation of viral entry in wild and domestic animals
|
microbiology
|
Using EEG Microstates to Examine Post-Encoding Quiet Rest and Subsequent Word-Pair Memory
|
neuroscience
|
Binding partners regulate unfolding of myosin VI to activate the molecular motor
|
biophysics
|
Characterization of an α-glucosidase enzyme conserved in Gardnerella spp. isolated from the human vaginal microbiome
|
microbiology
|
Nance-Horan Syndrome-like 1 protein negatively regulates Scar/WAVE-Arp2/3 activity and inhibits lamellipodia stability and cell migration.
|
cell biology
|
An optimal lysis time maximizes bacteriophage fitness in quasi-continuous culture
|
evolutionary biology
|
Spike frequency adaptation supports network computations on temporally dispersed information
|
neuroscience
|
Predicting Cortical Signatures of Consciousness using Dynamic Functional Connectivity Graph-Convolutional Neural Networks
|
neuroscience
|
Leaf shape and size variation in bur oaks: An empirical study and simulation of sampling strategies
|
plant biology
|
Root specific plasticity induced by paclobutrazol confers improved deficit irrigation tolerance and agronomic performance in maize
|
plant biology
|
Beta-adrenergic receptor signaling regulates ER-mitochondria contacts
|
cell biology
|
Origin of Novel Coronavirus (COVID-19): A Computational Biology Study using Artificial Intelligence
|
bioinformatics
|
Upregulated-flotillins and sphingosine kinase 2 derail vesicular trafic to stabilize AXL and promote epithelial-mesenchymal transition
|
cell biology
|
Dietary intervention improves health metrics and life expectancy of the genetically obese DU6 (Titan) mouse
|
physiology
|
Multi-scale modeling shows that dielectric differences make NaV channels faster than KV channels
|
biophysics
|
Predicting Parallelism and Quantifying Divergence in Experimental Evolution
|
evolutionary biology
|
Immune landscape of a genetically-engineered murine model of glioma relative to human glioma by single-cell sequencing
|
cancer biology
|
The scaffold protein IQGAP1 links heat-induced stress signals to alternative splicing regulation in gastric cancer cells
|
molecular biology
|
High temperature inhibits cnidarian-dinoflagellate symbiosis establishment through nitric oxide signaling
|
microbiology
|
Hyperbolic odorant mixtures as a basis for more efficient signaling between flowering plants and bees
|
animal behavior and cognition
|
A centrifuge-based method for identifying novel genetic traits that affect root-substrate adhesion in Arabidopsis thaliana
|
plant biology
|
Cell-extracellular matrix interactions in the fluidic phase direct the topology and polarity of self-organized epithelial structures
|
biophysics
|
Disease-relevant single cell photonic signatures identify S100β stem cells and their myogenic progeny in vascular lesions
|
cell biology
|
Slowly evolving dopaminergic activity modulates the moment-to-moment probability of movement initiation.
|
neuroscience
|
Fear Conditioning Potentiates the Hippocampal CA1 Commissural Pathway In vivo and Increases Awake Phase Sleep
|
neuroscience
|
Time-limited alterations in cortical activity of a Knock-in mice model of KCNQ2-related Developmental and Epileptic Encephalopathy
|
neuroscience
|
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