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Transcriptomically-inferred PI3K activity and stemness show a counterintuitive correlation with PIK3CA genotype in breast cancer
|
cancer biology
|
Age Influences on the Molecular Presentation of Tumours
|
cancer biology
|
Modeling Reveals Cortical Dynein-Dependent Fluctuations in Bipolar Spindle Length
|
cell biology
|
Gradual Compaction of the Central Spindle Decreases its Dynamicity as Revealed in PRC1 and EB1 Gene-Edited Human Cells
|
cell biology
|
Widespread retention of ohnologs in key developmental gene families following whole genome duplication in arachnopulmonates
|
developmental biology
|
The Broken Window: An algorithm for quantifying and characterizing misleading trajectories in ecological processes
|
ecology
|
Host-associated fungal communities are determined by host phylogeny and exhibit widespread associations with the bacterial microbiome
|
ecology
|
New perspectives on the calculation of bioaccumulation metrics for active substances in living organisms
|
ecology
|
Profiling the initial burst of beneficial genetic diversity in clonal cell populations to anticipate evolution
|
evolutionary biology
|
Large genetic diversity and strong positive selection in F-box and GPCR genes among the wild isolates of Caenorhabditis elegans
|
evolutionary biology
|
Multi-influential interactions alters behaviour and cognition through six main biological cascades in Down syndrome mouse models
|
genetics
|
Denisovan introgression has shaped the immune system of present-day Papuans
|
evolutionary biology
|
A Convolution Based Computational Approach Towards DNA N6-methyladenine Site Identification and Motif Extraction in Rice Genome
|
genomics
|
SARS-CoV-2 induces human plasmacytoid pre-dendritic cell diversification via UNC93B and IRAK4
|
immunology
|
Endogenous piRNA-guided slicing triggers responder and trailer piRNA production from viral RNA in Aedes aegypti mosquitoes
|
molecular biology
|
Knockout of the serotonin transporter in the rat mildly modulates decisional anhedonia
|
neuroscience
|
The organizational principles of de-differentiated topographic maps
|
neuroscience
|
Bayesian inference of population prevalence
|
neuroscience
|
Tomographic data of 'acanthodian' oral structures and a review of dental diversity in early chondrichthyans
|
paleontology
|
The everyday acoustic environment and its association with human heart rate: evidence from real-world data logging with hearing aids and wearables
|
physiology
|
Rubisco proton production can drive the elevation of CO2 within condensates and carboxysomes
|
plant biology
|
RefPlantNLR: a comprehensive collection of experimentally validated plant NLRs
|
plant biology
|
GRIDSS2: comprehensive characterisation of somatic structural variation using single breakend variants and structural variant phasing
|
bioinformatics
|
Genomic Mutations and Changes in Protein Secondary Structure and Solvent Accessibility of SARS-CoV-2 (COVID-19 Virus)
|
bioinformatics
|
Phage-delivered CRISPR-Cas9 for strain-specific depletion and genomic deletions in the gut microbiome
|
microbiology
|
The maintenance of polygenic sex determination depends on the dominance of fitness effects which are predictive of the role of sexual antagonism
|
evolutionary biology
|
Phylogenetically conserved peritoneal fibrosis response to an immunologic adjuvant in ray-finned fishes
|
evolutionary biology
|
Transcription Factor EB regulates phosphatidylinositol-3-phosphate levels on endomembranes and alters lysosome positioning in the bladder cancer model
|
cancer biology
|
Single-cell analysis of mosquito hemocytes identifies signatures of immune cell sub-types and cell differentiation
|
immunology
|
Modelling cell guidance and curvature control in evolving biological tissues
|
biophysics
|
Improved analyses of GWAS summary statistics by reducing data heterogeneity and errors
|
genetics
|
Kinetic assays of DNA polymerase fidelity: a new theoretical perspective beyond Michaelis-Menten kinetics
|
biophysics
|
Evolutionary conserved nitric oxide synthesis proteins responding to bacterial MAMPs are located to the endoplasmic reticulum and are also involved in secondary metabolite synthesis and sterol production
|
cell biology
|
Ventricular, atrial and outflow tract heart progenitors arise from spatially and molecularly distinct regions of the primitive streak.
|
developmental biology
|
Worth the effort? A practical examination of random effects in hidden Markov models for animal telemetry data
|
ecology
|
Nitrogen deposition is negatively related to species richness and abundance of threatened species in Swiss butterflies
|
ecology
|
Geography is more important than life history in the recent diversification of the tiger salamander complex
|
evolutionary biology
|
Whole-proteome Tree of Insects: Grouping and phylogeny without sequence alignment
|
evolutionary biology
|
ProtTrans: Towards Cracking the Language of Life's Code Through Self-Supervised Deep Learning and High Performance Computing
|
bioinformatics
|
A modelling framework for the prediction of the herd-level probability of infection from longitudinal data
|
bioinformatics
|
Bayesian Decoder Models with a Discriminative Observation Process
|
bioinformatics
|
Suppression of chromosome instability limits acquired drug resistance
|
cancer biology
|
Wide spectrum of neuronal and network phenotypes in human stem cell-derived excitatory neurons with Rett syndrome-associated MECP2 mutations
|
neuroscience
|
Independence of Cued and Contextual Components of Fear Conditioning is Gated by the Lateral Habenula
|
neuroscience
|
The Contribution of Environmental Enrichment to Phenotypic Variation in Mice and Rats
|
neuroscience
|
Effects of plant community history, soil legacy and plant diversity on soil microbial communities
|
ecology
|
The role of syndapin-2 mediated transcytosis across the blood-brain barrier on amyloid-beta accumulation in the brain
|
neuroscience
|
A Meta-analysis of the known Global Distribution and Host Range of the Ralstonia Species Complex
|
microbiology
|
SPACE exploration of RNA-binding proteins as major chromatin components
|
molecular biology
|
How robust are cross-population signatures of polygenic adaptation in humans?
|
genetics
|
Transcriptional analysis of Colletotrichum fructicola from Different Geographic regions inoculated to Camellia oleifera
|
microbiology
|
Causal inference in environmental sound recognition
|
animal behavior and cognition
|
Prophage-encoded phage defence proteins with cognate self-immunity
|
microbiology
|
Multitask Learning over Shared Subspaces
|
animal behavior and cognition
|
Cell type-aware analysis of RNA-seq data
|
bioinformatics
|
MAVE-NN: learning genotype-phenotype maps from multiplex assays of variant effect
|
bioinformatics
|
Predictive pre-activation of orthographic and lexical-semantic representations facilitates visual word recognition
|
neuroscience
|
Neural Network Poisson Models for Behavioural and Neural Spike Train Data
|
neuroscience
|
Linear vector models of time perception account for saccade and stimulus novelty interactions
|
neuroscience
|
PD-1-induced T cell exhaustion is controlled by a Drp1-dependent mechanism
|
immunology
|
The representation of bodies in high level visual, prefrontal and inferior parietal cortex varies with explicit vs. implicit expression perception
|
neuroscience
|
Accurate recognition of colorectal cancer with semi-supervised deep learning on pathological images
|
pathology
|
Collagen (I) homotrimer potentiates the osteogenesis imperfecta (oim) mutant allele and reduces survival in male mice
|
physiology
|
IWS1 phosphorylation promotes cell proliferation and predicts poor prognosis in EGFR mutant lung adenocarcinoma patients, through the cell cycle-regulated U2AF2 RNA splicing.
|
cancer biology
|
The lncRNA APOLO interacts with the transcription factor WRKY42 to trigger root hair cell expansion in response to cold
|
plant biology
|
Dynamics in Natural and Designed Elastins and Their Relation to Elastic Fiber Structure and Recoil
|
biophysics
|
Structural basis of DegP-protease temperature-dependent activation
|
biophysics
|
Bioinformatic Analysis of Structure and Function of LIM Domains of Human Zyxin Family Proteins
|
biochemistry
|
Validation and tuning of in situ transcriptomics image processing workflows with crowdsourced annotations
|
bioengineering
|
High-density Neural Recordings from Feline Sacral Dorsal Root Ganglia with Thin-film Array
|
bioengineering
|
Action Imagery and Observation in Neurorehabilitation for Parkinson's Disease (ACTION-PD): development and pilot randomised controlled trial of a user-informed home training intervention to improve everyday functional actions
|
neuroscience
|
What executive function network is that? An image-based meta-analysis of network labels
|
neuroscience
|
Cerebral laterality for writing in right- and left-handers: A functional transcranial Doppler ultrasound study
|
neuroscience
|
Spectral Signatures of L-DOPA-Induced Dyskinesia Depend on L-DOPA Dose and are Suppressed by Ketamine
|
pathology
|
MetaWorks: A flexible, scalable bioinformatic pipeline for high-throughput multi-marker biodiversity assessments
|
bioinformatics
|
Species packing and the latitudinal gradient in beta-diversity
|
ecology
|
GAF is essential for zygotic genome activation and chromatin accessibility in the early Drosophila embryo
|
developmental biology
|
Transcriptional response of the calcification and stress response toolkits in an octocoral under heat and pH stress
|
ecology
|
Graphein - a Python Library for Geometric Deep Learning and Network Analysis on Protein Structures and Interaction Networks
|
bioinformatics
|
Local Gazetteers Reveal Contrasting Patterns of Historical Distribution Changes between Apex Predators and Mesopredators in Eastern China
|
ecology
|
The Mycobacterium tuberculosis sRNA F6 modifies expression of essential chaperonins, GroEL2 and GroES
|
microbiology
|
Global transcriptional regulation by cell-free supernatant of Salmonella Typhimurium peptide transporter mutant leads to inhibition of intra-species biofilm initiation
|
microbiology
|
Global organization of neuronal activity only requires unstructured local connectivity
|
neuroscience
|
The planning horizon for movement sequences
|
neuroscience
|
Variability in infants functional brain network connectivity is associated with differences in affect and behavior
|
neuroscience
|
CLAMP and Zelda function together as pioneer transcription factors to promote Drosophila zygotic genome activation
|
genomics
|
Re-exposure to a sensorimotor perturbation produces opposite effects on explicit and implicit learning processes
|
neuroscience
|
Cas9 fusions for precision in vivo editing
|
synthetic biology
|
Mitochondria-dependent phase separation of disease-relevant proteins drives pathological features of age-related macular degeneration
|
neuroscience
|
Long-read-sequenced reference genomes of the seven major lineages of enterotoxigenic Escherichia coli (ETEC) circulating in modern time
|
genomics
|
Retinoic acid fluctuation activates an uneven, direction-dependent network-wide robustness response in early embryogenesis
|
developmental biology
|
Sense the Moment: a highly sensitive antimicrobial activity predictor based on hydrophobic moment
|
bioinformatics
|
Pathogen-driven coevolution across CBP60 plant immune regulator subfamilies confers resilience on the regulator module
|
evolutionary biology
|
Trade-off between reducing mutational accumulation and increasing commitment to differentiation determines tissue organization
|
evolutionary biology
|
Interleukin-10 suppression enhances T-cell antitumor immunity and responses to checkpoint blockade in chronic lymphocytic leukemia
|
immunology
|
Targeted intragenic demethylation initiates chromatin rewiring for gene activation
|
genetics
|
Nef enhances HIV-1 replication and infectivity independently of SERINC3 and SERINC5 in CEM T cells
|
microbiology
|
Parametric tests for Leave-One-Out Inter-Subject Correlations in fMRI provide adequate Type I error control while providing high sensitivity
|
neuroscience
|
Tau in the brain interstitial fluid is fragmented and seeding-competent
|
neuroscience
|
Mechanical overstimulation causes acute injury and synapse loss followed by fast recovery in lateral-line neuromasts of larval zebrafish
|
neuroscience
|
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