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Branched-Chain Amino Acid Metabolism is Regulated by ERRα in Primary Human Myotubes and is Further Impaired by Glucose Loading in Type 2 Diabetes
|
physiology
|
SARS-CoV-2 and SARS-CoV spike-mediated cell-cell fusion differ in the requirements for receptor expression and proteolytic activation
|
microbiology
|
The neuropeptides VIP and PACAP inhibit SARS-CoV-2 replication in monocytes and lung epithelial cells, decrease the production of proinflammatory cytokines, and VIP levels are associated with survival in severe COVID-19 patients.
|
microbiology
|
Interneuron Specific Gamma Synchronization Indexes Cue Uncertainty and Prediction Errors in Lateral Prefrontal and Anterior Cingulate Cortex
|
neuroscience
|
Eyes wide open: regulation of arousal by temporal expectations
|
neuroscience
|
RapidoPGS: A rapid polygenic score calculator for summary GWAS data without validation dataset
|
genetics
|
Temporally and Spatially Partitioned Neuropeptide Release from Individual Clock Neurons
|
neuroscience
|
Specific changes in sleep oscillations after blocking human metabotropic glutamate receptor 5 in the absence of altered memory function
|
neuroscience
|
A rapid ecological assessment for necrophagous flies (Diptera, Calyptratae) in a mosaic landscape of the Colombian Andes
|
ecology
|
Global dynamics of microbial communities emerge from local interaction rules
|
systems biology
|
Exploring Efficient Linear Mixed Models to Detect Quantitative Trait Locus-by-environment Interactions
|
genetics
|
The sleep-wake distribution contributes to the peripheral rhythms in PERIOD-2
|
physiology
|
A mitochondrial mutational signature of temperature in ectothermic and endothermicvertebrates.
|
evolutionary biology
|
Integration of phenomics and transcriptomics data to reveal drivers of inflammatory processes in the skin
|
immunology
|
De novo designed transmembrane domains tune engineered receptor functions
|
synthetic biology
|
partR2: Partitioning R2 in generalized linear mixed models
|
bioinformatics
|
Modeling the complete kinetics of coxsackievirus B3 reveals human determinants of host-cell feedback
|
systems biology
|
Structural and Genetic Determinants of Convergence in the Drosophila tRNA Structure-Function Map
|
molecular biology
|
Weak catch bonds make strong networks
|
biophysics
|
Including tree spatial extension in the evaluation of neighbourhood competition effects in Bornean rain forest
|
ecology
|
The Mouse Action Recognition System (MARS) software pipeline for automated analysis of social behaviors in mice
|
neuroscience
|
A small, computationally flexible network produces the phenotypic diversity of song recognition in crickets
|
neuroscience
|
Transcription factor binding activity is the primary driver of noise in gene expression
|
systems biology
|
Bro1 stimulates Vps4 activity to promote Intralumenal Vesicle Formation during Multivesicular Body biogenesis
|
cell biology
|
The ABCD Stop Signal Data: Response to Bissett et al.
|
neuroscience
|
Cortical Silent Period reflects individual differences in action stopping performance.
|
neuroscience
|
Minimizing ion competition boosts volatile metabolome analysis by secondary electrospray ionization orbitrap mass spectrometry
|
systems biology
|
coronaSPAdes: from biosynthetic gene clusters to RNA viral assemblies
|
bioinformatics
|
Systematic investigation of imprinted gene expression and enrichment in the mouse brain explored at single-cell resolution
|
genetics
|
Breathing Behaviors in Common Marmoset (Callithrix jacchus)
|
neuroscience
|
Unsupervised analysis of multi-experiment transcriptomic patterns with SegRNA identifies unannotated transcripts
|
bioinformatics
|
Stem girth changes in response to soil water potential in lowland dipterocarp forest in Borneo: a time-series analysis
|
ecology
|
Evaluation of Polygenic Prediction Methodology within a Reference-Standardized Framework
|
genomics
|
Biogeochemical and omic evidence for paradoxical methane production via multiple co-occurring mechanisms in aquatic ecosystems
|
genomics
|
From plants to ants: Fungal modification of leaf lipids for nutrition and communication in the leaf-cutter ant fungal garden ecosystem
|
systems biology
|
Estradiol Action at the Median Preoptic Nucleus is Necessary and Sufficient for Sleep Suppression in Female Rats
|
neuroscience
|
ExBoX: a simple Boolean exclusion strategy to drive expression in neurons
|
neuroscience
|
Predictive visuo-motor communication through neural oscillations
|
neuroscience
|
Global drivers of obligate mycorrhizal symbionts diversification
|
evolutionary biology
|
Nonlinear effects of intrinsic dynamics on temporal encoding in a model of avian auditory cortex
|
neuroscience
|
APOBEC2 is a Transcriptional Repressor 1 required for proper Myoblast Differentiation
|
molecular biology
|
The ciliary protein IFT88 controls post-natal cartilage thickness and influences development of osteoarthritis.
|
molecular biology
|
Intrinsic excitability mechanisms of neuronal ensemble formation
|
neuroscience
|
MafF is an antiviral host factor that suppresses transcription from Hepatitis B Virus core promoter
|
microbiology
|
Single-nuclei transcriptomics of schizophrenia prefrontal cortex primarily implicates neuronal subtypes
|
neuroscience
|
The influence of autotoxicity on the dynamics of vegetation spots
|
ecology
|
Non-parametric modelling of temporal and spatial counts data from RNA-seq experiments
|
bioinformatics
|
Pulsations and flows in tissues: two collective dynamics with simple cellular rules
|
biophysics
|
Functional and genetic determinants of mutation rate variability in regulatory elements of cancer genomes
|
genomics
|
How does an ectodomain of membrane-associated proteins stand upright and exert robust signal
|
immunology
|
Per1/Per2-Igf2 axis-mediated circadian regulation of myogenic differentiation
|
developmental biology
|
Zinc Sulfide-Based Hybrid Exosome-Coated Nanoplatform for Targeted Treatment of Glioblastoma in an Orthotopic Mouse Glioblastoma Model
|
pharmacology and toxicology
|
Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties
|
neuroscience
|
Reversible fronto-occipitotemporal signaling complements task encoding and switching under ambiguous cues
|
neuroscience
|
A Murine Model for Enhancement of Streptococcus pneumoniae Pathogenicity Upon Viral Infection and Advanced Age
|
microbiology
|
A persistent giant algal virus, with a unique morphology, encodes an unprecedented number of genes involved in energy metabolism
|
microbiology
|
Inference of long-range cell-cell mechanical communication from ECM remodeling fluctuations
|
cell biology
|
Nanopore sequencing reveals full-length Tropomyosin 1 isoforms and their regulation by RNA binding proteins during rat heart development
|
molecular biology
|
Targeted downregulation of estradiol binding Na+/H+ exchanger nhx-2, mimics calorie restriction, extends reproductive longevity and ameliorates effects associated with alpha synuclein aggregation in C. elegans
|
neuroscience
|
Dynamics of nonlinguistic statistical learning: From neural entrainment to the emergence of explicit knowledge
|
neuroscience
|
Direct Antimicrobial Resistance Prediction from clinical MALDI-TOF mass spectra using Machine Learning
|
microbiology
|
Novel mechanistic insights into the role of Mer2 as the keystone of meiotic DNA break formation
|
biochemistry
|
singlecellVR: interactive visualization of single-cell data in virtual reality
|
genomics
|
RIP140 inhibits glycolysis-dependent proliferation of breast cancer cells by regulating GLUT3 expression through transcriptional crosstalk between hypoxia induced factor and p53
|
cancer biology
|
Quantitative sub-cellular acyl-CoA analysis reveals distinct nuclear regulation
|
biochemistry
|
Fluency shaping increases integration of the command-to-execution and the auditory-to-motor pathways in persistent developmental stuttering
|
neuroscience
|
Young Infants Process Prediction Errors at the Theta Rhythm
|
neuroscience
|
CAR/Nr1i3 directs T cell adaptation to bile acids in the small intestine
|
immunology
|
Helicase-Like Functions in Phosphate Loop Containing Beta-Alpha Polypeptides
|
molecular biology
|
Trophic niche of the invasive gregarious species Crepidula fornicata, in relation to ontogenic changes
|
ecology
|
Pervasive selection biases inferences of the species tree
|
evolutionary biology
|
Parasitism and host dispersal plasticity in an aquatic model system
|
evolutionary biology
|
Genetics of resistance to common root rot (spot blotch), Fusarium crown rot, and sharp eyespot in wheat
|
genetics
|
Sexual dimorphism of synaptonemal complex length among populations of threespine stickleback fish
|
genetics
|
The first steps toward a global pandemic: Reconstructing the demographic history of parasite host switches in its native range
|
genomics
|
THE REGULATORY EFFECT OF LIGHT OVER FRUIT DEVELOPMENT AND RIPENING IS MEDIATED BY EPIGENETIC MECHANISMS
|
plant biology
|
Midcell localization of PBP4 of Escherichia coli is modulating the timing of divisome assembly
|
microbiology
|
Estimating Genetic Similarity Matrices using Phylogenies
|
genetics
|
Host-mediated, cross-generational intraspecific competition in a herbivore species
|
ecology
|
How we pay attention in naturalistic settings
|
neuroscience
|
Root electrotropism in Arabidopsis does not depend on auxin distribution but requires cytokinin biosynthesis
|
plant biology
|
Neural repetition suppression modulates time perception: evidence from electrophysiology and pupillometry
|
neuroscience
|
Rapid Online Assessment of Reading Ability
|
animal behavior and cognition
|
Retracing Schwann cell developmental transitions in embryonic dissociated DRG/Schwann cell cocultures in mice
|
neuroscience
|
Multiplex-GAM: genome-wide identification of chromatin contacts yields insights not captured by Hi-C
|
molecular biology
|
Distinguishing between recent balancing selection and incomplete sweep using deep neural networks
|
evolutionary biology
|
Visuospatial attention updates the cortical representation of sound under reduced sensory uncertainty
|
neuroscience
|
Immunomodulatory Contribution of Mast Cells to the Biomaterial Microenvironment
|
bioengineering
|
CellPhy: accurate and fast probabilistic inference of single-cell phylogenies from scDNA-seq data
|
bioinformatics
|
Dense poly(ethylene glycol) coatings maximize nanoparticle transport across lymphatic endothelial cells and accumulate in the skin draining lymph nodes
|
bioengineering
|
Assessing Confidence in Root Placement on Phylogenies: An Empirical Study Using Non-Reversible Models for Mammals
|
evolutionary biology
|
The vesicular release probability sets the strength of individual Schaffer collateral synapses
|
neuroscience
|
A Unified Framework for Lineage Tracing and Trajectory Inference
|
developmental biology
|
Timing of neurogenesis through sequential accumulation of miR-9 due to additive expression of multiple alleles
|
developmental biology
|
Model-based genotype and ancestry estimation for potential hybrids with mixed-ploidy
|
genetics
|
A structured observation distribution for generative biological sequence prediction and forecasting
|
genomics
|
SLO2.1 and NALCN form a functional complex to modulate myometrial cell excitability
|
cell biology
|
Integrated tapered fibertrode for simultaneous control and readout of neural activity over small brain volumes with reduced light-induced artefacts
|
neuroscience
|
Src activates retrograde membrane traffic through phosphorylation of GBF1
|
cell biology
|
Esrrb is a cell cycle dependent priming factor balancing between pluripotency and differentiation
|
molecular biology
|
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