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Ultra-high sensitivity mass spectrometry quantifies single-cell proteome changes upon perturbation
|
systems biology
|
GABA relates to functional connectivity changes and retention in visuomotor adaptation
|
neuroscience
|
Identification of molecular candidates which regulate calcium-dependent CD8+ T-cell cytotoxicity
|
immunology
|
Phylogenetic and population structure analyses uncover pervasive misclassification and help assessing the biosafety of Pseudomonas putida for biotechnological applications
|
microbiology
|
The anatomy of a phenological mismatch: interacting consumer demand and resource characteristics determine the consequences of mismatching
|
ecology
|
Interplay between extreme drift and selectionintensities favors the fixation of beneficial mutations in selfing maize populations
|
evolutionary biology
|
Virtue as the mean: Pan-human consensus genome significantly improves the accuracy of RNA-seq analyses
|
bioinformatics
|
Identifying and testing marker-trait associations for growth and phenology in three pine species
|
plant biology
|
Female meiosis II and pronuclear fusion require Bicaudal-D
|
developmental biology
|
The Ensembl COVID-19 resource: Ongoing integration of public SARS-CoV-2 data
|
bioinformatics
|
The evolutionary assembly of forest communities along environmental gradients: recent diversification or sorting of pre-adapted clades?
|
ecology
|
Evolutionary tracking of SARS-CoV-2 genetic variants highlights intricate balance of stabilizing and destabilizing mutations
|
genomics
|
SARS-CoV-2 Genomic Surveillance in Costa Rica: Evidence of a Divergent Population and an Increased Detection of a Spike T1117I Mutation
|
genomics
|
15-PGDH Regulates Hematopoietic and Gastrointestinal Fitness During Aging
|
pathology
|
Diffusion Fails to Make a Stink
|
biophysics
|
The assisting role of Polη in transcription facilitates formation of damage-induced cohesion
|
cell biology
|
Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes
|
genetics
|
Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex
|
biochemistry
|
RoDiCE: Robust differential protein co-expression analysis for cancer complexome
|
bioinformatics
|
SLIDR and SLOPPR: Flexible identification of spliced leader trans-splicing and prediction of eukaryotic operons from RNA-Seq data
|
bioinformatics
|
Distinct Protofilament-scale Dynamics Define the Differential Remodeling of Microtubule Arrays
|
biophysics
|
Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk
|
pharmacology and toxicology
|
Sting orchestrates the crosstalk between polyunsaturated fatty acids metabolism and inflammatory responses
|
immunology
|
A WDR35-dependent coatomer transports ciliary membrane proteins from the Golgi to the cilia
|
cell biology
|
Narratives: fMRI data for evaluating models of naturalistic language comprehension
|
neuroscience
|
Herpes Simplex Virus Co-Infection Facilitates Rolling Circle Replication of the Adeno-Associated Virus Genome
|
microbiology
|
Drosophila glue protects from predation
|
evolutionary biology
|
Evolution of a virus-like architecture and packaging mechanism in a repurposed bacterial protein
|
biochemistry
|
A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process
|
biochemistry
|
Brucella ovis cysteine biosynthesis contributes to peroxide stress survival and fitness in the intracellular niche
|
microbiology
|
Are specialised ABC transporters responsible for the circularisation of type I circular bacteriocins?
|
microbiology
|
Development of a novel hybrid alphavirus-SARS-CoV-2 particle for rapid in vitro screening and quantification of neutralization antibodies, viral variants, and antiviral drugs
|
microbiology
|
Tyrosinase from mushroom Agaricus bisporus as an inhibitor of the Hepatitis C virus
|
microbiology
|
Isolation and characterization of Pseudomonas chlororaphis strain ST9 and its potential as a bioinoculant for agriculture
|
microbiology
|
Shared population-level dynamics in monkey premotor cortex during solo action, joint action and action observation
|
neuroscience
|
Are indigenous territories effective natural climate solutions? A neotropical analysis using matching methods and geographic discontinuity designs.
|
ecology
|
Variation and process of life history evolution in insular dwarfism as revealed by a natural experiment
|
evolutionary biology
|
Massive colonization of protein-coding exons by selfish genetic elements in Paramecium germline genomes
|
genomics
|
Functional architecture of the pancreatic islets: First responder cells drive the first-phase response
|
biophysics
|
MaPPeRTrac: A Massively Parallel, Portable, and Reproducible Tractography Pipeline
|
neuroscience
|
4sUDRB-sequencing for genome-wide transcription bursting quantification in breast cancer cells
|
molecular biology
|
Maize (Zea mays L.) nucleoskeletal proteins regulate nuclear envelope remodeling and function in stomatal complex development and pollen viability.
|
cell biology
|
Coalescent-based species delimitation meets deep learning: Insights from a highly fragmented cactus system
|
evolutionary biology
|
RgCop-A regularized copula based method for gene selection in single cell rna-seq data
|
bioinformatics
|
Multi-class Cancer Classification and Biomarker Identification using Deep Learning
|
bioinformatics
|
Upregulation of DNA repair genes and cell extrusion underpin the remarkable radiation resistance of Trichoplax adhaerens.
|
cancer biology
|
Red-beet betalain pigment inhibits amyloid-β aggregation and toxicity in amyloid-β expressing Caenorhabditis elegans model
|
pharmacology and toxicology
|
Effector-independent brain network for auditory-motor integration: fMRI evidence from singing and cello playing
|
neuroscience
|
In vivo visualization of pig vagus nerve 'vagotopy' using ultrasound
|
neuroscience
|
Multidimensional brain-age prediction reveals altered brain developmental trajectory in psychiatric disorders
|
neuroscience
|
Mapping the probability of forest snowdisturbances in Finland
|
ecology
|
Assembly and Validation of Two Gap-free Reference Genomes for Xian/indica Rice Reveals Insights into Plant Centromere Architecture
|
genomics
|
Preclinical drug response metric based on cellular response phenotype provides better pharmacogenomic variables with phenotype relevance
|
pharmacology and toxicology
|
Constructing neural network models from brain data reveals representational transformations underlying adaptive behavior
|
neuroscience
|
CLN5 and CLN3 function as a complex to regulate endolysosome function
|
cell biology
|
Genomic signature of shifts in selection and alkaline adaptation in highland fish
|
evolutionary biology
|
Cytoplasmic and nuclear Sw-5b NLR act both independently and synergistically to dictate full host defense against tospovirus infection
|
plant biology
|
Ultrasensitivity and bistability in covalent modification cycles with positive autoregulation
|
systems biology
|
An open source platform for presenting dynamic visual stimuli
|
neuroscience
|
Remdesivir-Ivermectin combination displays synergistic interaction with improved in vitro antiviral activity against SARS-CoV-2
|
microbiology
|
Modelling of SHMT1 riboregulation predicts dynamic changes of serine and glycine levels across cellular compartments
|
biochemistry
|
Authentication of In Situ Measurements for Thoracic Aortic Aneurysms in Mice
|
pathology
|
Sustained antibody response to ZIKV infection induced by NS1 protein is accompanied by the progressive appearance of autoreactive antibodies and cross-reactive B cell clones.
|
immunology
|
SARS-CoV-2 infecting the inner ear results in potential hearing damage at the early stage or prognosis of COVID-19 in rodents
|
bioinformatics
|
Role of hypothalamic MAPK/ERK signaling in diabetes remission induced by the central action of fibroblast growth factor 1
|
neuroscience
|
Evaluating performance of existing computational models in predicting CD8+ T cell pathogenic epitopes and cancer neoantigens
|
immunology
|
Host-generalist fungal pathogens of seedlings may maintain forest diversity via host-specific impacts and differential susceptibility among tree species
|
ecology
|
Automated Analysis of Low-Field Brain MRI in Cerebral Malaria
|
neuroscience
|
Genetic epidemiology of variants associated with immune escape from global SARS-CoV-2 genomes
|
bioinformatics
|
Differential Dynamic Behavior of Prefusion Spike Proteins of SARS Coronaviruses 1 and 2
|
biophysics
|
TCR meta-clonotypes for biomarker discovery with tcrdist3: identification of public, HLA-restricted SARS-CoV-2 associated TCR features
|
immunology
|
Drs2 regulates TRAPPIII in Atg9 transport: exposing the interplay of P4-ATPases and Multisubunit Tethering Complexes
|
cell biology
|
Neuronal cascades shape whole-brain functional dynamics at rest
|
neuroscience
|
A small increase in CHEK1 activity leads to the arrest of the first zygotic division in human
|
developmental biology
|
X-MOL: large-scale pre-training for molecular understanding and diverse molecular analysis
|
bioinformatics
|
Pairs of compensatory frameshifting mutations contribute to evolution of protein-coding sequences in vertebrates and insects
|
evolutionary biology
|
SARS-CoV-2 mutations among minks show reduced lethality and infectivity to humans
|
microbiology
|
The chirality of the mitotic spindle provides a passive mechanical response to forces and depends on microtubule motors and crosslinkers
|
cell biology
|
The mechanism of SARS-CoV-2 nucleocapsid protein recognition by the human 14-3-3 proteins
|
biochemistry
|
IWS1 phosphorylation by AKT3 controls nuclear export of type I IFN mRNAs and sensitivity to oncolytic viral infection, by regulating the alternative RNA splicing of U2AF2.
|
cancer biology
|
Enhancing bioreactor arrays for automated measurements and reactive control with ReacSight
|
synthetic biology
|
Road salt compromises functional morphology of larval gills in populations of an amphibian
|
ecology
|
Measuring thermodynamic preferences to form non-native conformations in nucleic acids using melting experiments reveals a rich sequence-specific DNA conformational landscape
|
biophysics
|
Spatio-temporal dynamics of intra-host variability in SARS-CoV-2 genomes
|
genomics
|
Endothelial SOCS3 maintains homeostasis and promotes survival in endotoxemic mice
|
cell biology
|
Matrix stiffness and blood pressure together regulate vascular smooth muscle cell phenotype switching and cofilin dependent podosome formation
|
cell biology
|
Identification of proximal SUMO-dependent interactors using SUMO-ID
|
biochemistry
|
CKS1-dependent proteostatic regulation has dual roles combating acute myeloid leukemia whilst protecting normal hematopoiesis
|
cancer biology
|
Single cell gene fusion detection by scFusion
|
bioinformatics
|
Feeding intervention potentiates the effect of mechanical loading to induce new bone formation in mice
|
physiology
|
Adaptation to host cell environment during experimental evolution of Zika virus
|
microbiology
|
Coupling between ribotypic and phenotypic traits of protists across life-cycle stages and temperatures
|
microbiology
|
ADH5-mediated NO Bioactivity Maintains Metabolic Homeostasis in Brown Adipose Tissue
|
molecular biology
|
Locally-adaptive inversions modulate genetic variation at different geographic scales in a seaweed fly
|
evolutionary biology
|
Effect of Stapling on the Thermodynamics of mdm2-p53 Binding
|
biochemistry
|
Analysis and Forecasting of Global RT-PCR Primers for SARS-CoV-2
|
bioinformatics
|
Cortical layer-specific modulation of neuronal activity after sensory deprivation due to spinal cord injury
|
neuroscience
|
Rapid inactivation in vitro of SARS-CoV-2 in saliva by black tea and green tea
|
microbiology
|
Functional evolution of a bark beetle odorant receptor clade detecting monoterpenoids of different ecological origins
|
molecular biology
|
Reversion is most likely under high mutation supply, when compensatory mutations don't fully restore fitness costs
|
evolutionary biology
|
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