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Superfast Evolution of Multi-drug Antibiotic Resistance
|
microbiology
|
The outer mitochondrial membrane protein TMEM11 is a novel negative regulator of BNIP3/BNIP3L-dependent receptor-mediated mitophagy
|
cell biology
|
Discovery of a druggable copper-signaling pathway that drives cell plasticity and inflammation
|
cell biology
|
Subcellular mapping of the protein landscape of SARS-CoV-2 infected cells for target-centric drug repurposing
|
cell biology
|
A multidisciplinary analysis of the as-isolated Escherichia coli SufBC2D complex reveals the presence of two new iron-sulfur clusters
|
biochemistry
|
Predicting Protein Function and Orientation on a Gold Nanoparticle Surface Using a Residue-Based Affinity Scale
|
biophysics
|
Reactive oxygen species generated by infrared laser light in optical tweezers inhibits the germination of bacterial spores
|
biophysics
|
Inositol hexakisphosphate (IP6) accelerates immature HIV-1 Gag protein assembly towards kinetically-trapped morphologies
|
biophysics
|
Base editing screens map mutations affecting IFNγ signalling in cancer
|
cancer biology
|
spongEffects: ceRNA modules offer patient-specific insights into the miRNA regulatory landscape
|
systems biology
|
Glia-neuron coupling via a bipartite sialylation pathway promotes neural transmission and stress tolerance in Drosophila
|
neuroscience
|
Neuron-specific transcriptomic signatures indicate neuroinflammation and altered neuronal activity in ASD temporal cortex
|
neuroscience
|
Convergent epitope specificities, V gene usage and public clones elicited by primary exposure to SARS-CoV-2 variants
|
immunology
|
Phylogenetic analysis of the origin and spread of plague in Madagascar
|
microbiology
|
Characterization of the growth and morphology of a BSL-2 Coccidioides posadasii strain that persists in the parasitic life cycle at ambient CO2.
|
microbiology
|
PinR as a Stress Inducible Inhibitory Transcription Factor in Stopping Stress-induced Mutagenesis Bacterial Evolution of Antibiotic Resistance
|
microbiology
|
Tuberculosis treatment failure associated with evolution of antibiotic resilience
|
microbiology
|
DNA methylation in human gastric epithelial cells allows cell type-related plasticity and defines regional identity
|
molecular biology
|
Regulation of EBNA1 Protein Stability by PLOD1 Lysine Hydroxylase
|
molecular biology
|
Structural basis of actin filament assembly and aging
|
biochemistry
|
Driving Forces underlying Selectivity Filter Gating in the MthK Potassium Channel
|
biophysics
|
Repeated ethanol exposure and withdrawal alters ACE2 expression in discrete brain regions: Implications for SARS-CoV-2 infection
|
neuroscience
|
CD169-mediated restrictive SARS-CoV-2 infection of macrophages induces pro-inflammatory responses
|
immunology
|
ZccE is a Novel P-type ATPase That Protects Streptococcus mutans Against Zinc Intoxication
|
microbiology
|
Dynamic de novo adipose tissue development during metamorphosis in Drosophila melanogaster
|
developmental biology
|
The addition of antibiotics to embryo culture media caused altered expression of genes in pathways governing DNA integrity in mouse blastocysts
|
developmental biology
|
Lack of universal mutational biases in a fungal phylum
|
evolutionary biology
|
THRONCAT: Efficient metabolic labeling of newly synthesized proteins using a bioorthogonal threonine analog
|
cell biology
|
Evolution of decreased aggression in honey bees targeted brain cell gene regulatory networks
|
genomics
|
TOR acts as metabolic gatekeeper for auxin-dependent lateral root initiation in Arabidopsis thaliana
|
plant biology
|
Xanthomonas infection transforms the apoplast into an accessible and habitable niche for Salmonella enterica
|
microbiology
|
Lifting the ban on nuclear import activates Gdown1-mediated modulation of global transcription and facilitates adaptation to cellular stresses
|
cell biology
|
PPAR-γ activation promotes xenogenic bioroot regeneration by attenuating the xenograft induced-oxidative stress
|
cell biology
|
Mechano-redox control of Mac-1 de-adhesion from ICAM-1 by protein disulfide isomerase promotes directional movement of neutrophils under flow
|
biochemistry
|
Novel assays monitoring direct glucocorticoid receptor protein activity exhibit high predictive power for ligand activity on endogenous gene targets
|
pharmacology and toxicology
|
Membrane compartmentalization of Ect2/Cyk4/Mklp1 and NuMA/dynein/dynactin is essential for cleavage furrow formation during anaphase
|
cell biology
|
Accounting for cis-regulatory constraint prioritizes genes likely to affect species-specific traits
|
evolutionary biology
|
Right Anterior Theta Connectivity Predicts Autistic Social Traits in Neurotypical Children
|
neuroscience
|
Neuroimaging within the Dominantly Inherited Alzheimer's Network (DIAN): PET and MRI
|
neuroscience
|
Lagrangian Formalism in Biology: I. Standard Lagrangians and their Role in Population Dynamics
|
ecology
|
Quantifying the capacity for assisted migration to achieve conservation and forestry goals under climate change
|
ecology
|
Genomic demography of world's ethnic groups and their genomic identity between two individuals
|
evolutionary biology
|
Development of a new 3D tracking system for multiple marmosets under free-moving conditions
|
animal behavior and cognition
|
DTSyn: a dual-transformer-based neural network to predict synergistic drug combinations
|
bioinformatics
|
Pain as a Trigger for Epigenetic Modifications in Limbic Circuitry
|
neuroscience
|
Patient-derived recombinant autoantibodies reveal the subcellular neuroglial distribution and heterogeneous interactome of leucine-rich glioma-inactivated 1
|
neuroscience
|
Focal Non-invasive Deep-brain Stimulation with Temporal Interference for the Suppression of Epileptic Biomarkers
|
neuroscience
|
Sleep spindles favor emotion regulation over memory consolidation of stressors in PTSD
|
neuroscience
|
Application of B cell immortalization for the isolation of antibodies and B cell clones from vaccine and infection settings
|
immunology
|
The human placenta dictates the phenotype of decidual macrophages.
|
immunology
|
A machine learning method for estimating the probability of presence using presence-background data
|
ecology
|
Sex differences in allometry for phenotypic traits indicate that females are not scaled males
|
evolutionary biology
|
High-density mapping of QTL controlling agronomically important traits in quinoa (Chenopodium quinoa Willd.)
|
genetics
|
Acoustic signatures in cavefish populations inhabiting different caves
|
animal behavior and cognition
|
The growth rate of DNA condensate droplets increases with the size of participating subunits
|
bioengineering
|
Boquila: NGS read simulator to eliminate read nucleotide bias in sequence analysis
|
bioinformatics
|
Transcriptional dynamics of colorectal cancer risk associated variation at 11q23.1 are correlated with tuft cell abundance and marker expression in silico
|
bioinformatics
|
Imputation of Low-density Marker Chip Data in Plant Breeding: Evaluation of Methods Based on Sugar Beet
|
bioinformatics
|
Optimal inference of molecular interactions in live FRET imaging
|
biophysics
|
Effects of taurine in mice and zebrafish behavioral assays with translational relevance to schizophrenia
|
pharmacology and toxicology
|
Toward a first principles understanding of the activation and deactivation mechanisms of class A G-protein coupled receptors and voltage-gated cation channels
|
pharmacology and toxicology
|
Enhanced performance in perceptual decision making task without deprivation in mice using medial forebrain bundle stimulation
|
neuroscience
|
Large scale in vivo acquisition, segmentation and 3D reconstruction of cortical vasculature using functional ultrasound imaging.
|
neuroscience
|
Reanalysis of double EphA3 knockin maps in mouse shows the importance of chemoaffinity in topographic map formation
|
neuroscience
|
Immune chromatin reader SP140 regulates microbiota and risk for inflammatory bowel disease
|
immunology
|
Correlative SIP-FISH-SEM-Raman-NanoSIMS links identity, morphology, biochemistry, and physiology of environmental microbes
|
microbiology
|
Acinetobacter baumannii sampled from cattle and pigs represent novel clones
|
microbiology
|
Transcriptomics, Regulatory Syntax, and Enhancer Identification in Heterogenous Populations of Mesoderm-Induced ESCs at Single-Cell Resolution
|
developmental biology
|
Generation of raptor diversity in Europe: linking speciation to climate changes and the ability to migrate
|
evolutionary biology
|
Do amplifiers of selection maximise average fitness?
|
evolutionary biology
|
Phylogenomics Illuminates the Evolutionary History of Wild Silkmoths in Space and Time (Lepidoptera: Saturniidae)
|
evolutionary biology
|
Mesoscopic oblique plane microscopy (Meso-OPM) - enabling large-scale 4D isotropic cellular resolution imaging with a diffractive light sheet
|
bioengineering
|
scAllele: a versatile tool for the detection and analysis of variants in scRNA-seq
|
bioinformatics
|
MultiHeadGAN: A Deep Learning Method for Low Contrast Retinal Pigment Epithelium Cells Segmentation in Fluorescent Flatmount Microscopy Images
|
bioinformatics
|
A Quantitative Modelling Approach for DNA Repair on a Population Scale
|
bioinformatics
|
A high-throughput 384-well CometChip platform reveals a role for 3-methyladenine in the cellular response to etoposide-induced DNA damage
|
cancer biology
|
The sugarless grape trait characterized by single berry phenotyping
|
plant biology
|
Memory reactivation in slow wave sleep enhances relational learning
|
neuroscience
|
Multi-Layered Maps of Neuropil with Segmentation-Guided Contrastive Learning
|
neuroscience
|
A comparison of intracranial volume estimation methods and their cross-sectional and longitudinal associations with age
|
neuroscience
|
Population genetic analysis reveals the role of natural selection and phylogeography on genome-wide diversity in an extremely compact and reduced microsporidian genome
|
evolutionary biology
|
Holobiont transcriptomes for the critically endangered staghorn coral (Acropora cervicornis) from two environmentally distinct sites on Turneffe Atoll, Belize
|
genomics
|
Effects of low intensity pulsed ultrasound stimulation on metabolic lipolysis of adipocytes
|
bioengineering
|
Protein language models trained on multiple sequence alignments learn phylogenetic relationships
|
bioinformatics
|
A Distinct Chromatin State Drives Therapeutic Resistance in Invasive Lobular Breast Cancer
|
cancer biology
|
Establishing combination PAC-1 and TRAIL regimens for treating ovarian cancer based on patient-specific pharmacokinetic profiles using in silico clinical trails
|
cancer biology
|
Measurement of plant water status via static uniaxial compression of the leaf lamina
|
plant biology
|
The origin of diffuse noxious inhibitory controls
|
neuroscience
|
Novel Adult Cortical Neuron Processing and Screening method illustrates Sex- and Age-dependent effects of pharmaceutical compounds
|
neuroscience
|
Different astrocyte-to-neuron conversion tracing reporters affect results in mouse striatum under Ptbp1 knockdown
|
neuroscience
|
Bacteriophages antagonize cGAS-like immunity in bacteria
|
microbiology
|
NtrC expression at lag-phase improves competitive fitness under low and fluctuating nutrient condition
|
microbiology
|
Multiethnic Polygenic Risk Prediction in Diverse Populations through Transfer Learning
|
genetics
|
GTAGMe-seq: joint profiling of genetic variants, DNA methylation, GpC methyltransferase footprints, and 3D genome in the same DNA molecules
|
genomics
|
On the Geometry of Interacting Axon Tracts in Relation to Their Functional Properties
|
neuroscience
|
ACE2 engagement exposes the fusion peptide to pan-coronavirus neutralizing antibodies
|
immunology
|
The Structural and Biochemical Basis for FER Receptor Kinase Early Signaling Initiation in Arabidopsis
|
biochemistry
|
Sabatier principle for rationalizing enzymatic hydrolysis of a synthetic polyester
|
biochemistry
|
Endothelial Caspase-9 Promotes Glial Changes, Inflammation, and Contrast Sensitivity Decline in Retinal Vascular Injury
|
neuroscience
|
Homozygous CADPS2 mutations cause neurodegenerative disease with Lewy bodies in parrots
|
neuroscience
|
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