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Selective IL13Rα2-Targeted Functionality of IL13-Ligand CARs is Enhanced by Inclusion of 4-1BB Co-Stimulation
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immunology
|
SARS-CoV-2 accessory protein ORF8 decreases antibody-dependent cellular cytotoxicity
|
immunology
|
Improved fluorescent Listeria spp. biosensors for analysis of antimicrobials by flow cytometry
|
microbiology
|
CRISPRi screen for enhancing heterologous α-amylase yield in Bacillus subtilis
|
microbiology
|
Orphan nuclear receptors promote alternative lengthening of telomeres (ALT) through ALT-associated PML bodies
|
molecular biology
|
Structural insights into crista junction formation by the Mic60-Mic19 complex
|
cell biology
|
In vitro reconstitution of calcium-dependent recruitment of the human ESCRT machinery in lysosomal membrane repair
|
cell biology
|
A partnership of the lipid scramblase XK and of the lipid transfer protein VPS13A at the plasma membrane
|
cell biology
|
Evolution of CRISPR-associated Endonucleases as Inferred from Resurrected Proteins
|
evolutionary biology
|
Characterizing Photosynthetic Biofuel Production: Isotopically non-stationary 13C metabolic flux analysis (INST-13CMFA) on limonene producingSynechococcus sp. PCC 7002
|
bioengineering
|
Differential gene expression profiling reveals potential biomarkers and pharmacological compounds against SARS-CoV-2: insights from machine learning and bioinformatics approaches
|
bioinformatics
|
Predicting variability in nascent RNA from transcription initiation kinetics
|
biophysics
|
Comparative Structural and Dynamics Study of Free and gRNA-bound FnCas9 and SpCas9 Proteins
|
biophysics
|
Intracellular Aβ42 aggregation leads to cellular thermogenesis
|
biophysics
|
Patient-associated mutations in Drosophila Alk perturb neuronal differentiation and promote survival
|
cancer biology
|
WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation
|
cancer biology
|
PRMT5 is a therapeutic target in choroidal neovascularization
|
pharmacology and toxicology
|
Interfering with plant developmental timing promotes susceptibility to insect vectors of a bacterial parasite
|
plant biology
|
HTL/KAI2 signalling substitutes for light to control plant germination
|
plant biology
|
A mini-TGA protein, lacking a functional DNA-binding domain, modulates gene expression through heterogeneous association with transcription factors
|
plant biology
|
Proteomic characterization of spinal cord synaptoneurosomes from Tg-SOD1/G93A mice supports a role for MNK1 and local translation in the early stages of amyotrophic lateral sclerosis
|
neuroscience
|
TGFβ limits Myc-dependent TCR-induced metabolic reprogramming in CD8+ T cells
|
immunology
|
Controlling taxa abundance improves metatranscriptomics differential analysis
|
microbiology
|
Obligate sexual reproduction of a homothallic fungus closely related to the Cryptococcus pathogenic species complex
|
microbiology
|
Emerging Roles of Importin alpha/beta and EB1 in Differential Regulation of Kif18B Astral Microtubule Destabilization
|
cell biology
|
A conserved PLK1 docking site in TopBP1 maintains genome integrity during mitosis
|
cell biology
|
Species Distribution Modeling of Aedes aegypti in Maricopa County, Arizona from 2014-2020
|
ecology
|
Genetic surveillance of SARS-CoV-2 Mpro reveals high sequence and structural conservation prior to the introduction of protease inhibitor Paxlovid
|
genomics
|
Mechanism and consequence of daily modulation of cortical parvalbumin-positive inhibitory neurons
|
neuroscience
|
Convergent impact of schizophrenia risk genes
|
neuroscience
|
Longer metaphase and fewer chromosome segregation errors in modern human than Neandertal brain development
|
neuroscience
|
Inhibiting presynaptic calcium channel mobility in the auditory cortex suppresses synchronized input processing
|
neuroscience
|
Glucocorticoids Mediate Transcriptome-wide Alternative Polyadenylation: Mechanisms and Functional Implications
|
genomics
|
Jumping out of trouble: Evidence for a cognitive map in guppies (Poecilia reticulata)
|
animal behavior and cognition
|
3D Organic Bioelectronics for Monitoring In Vitro Stem Cell Cultures
|
bioengineering
|
Transcriptome of the coralline alga Calliarthron tuberculosum (Corallinales, Rhodophyta) reveals convergent evolution of a partial lignin biosynthesis pathway
|
plant biology
|
Human Digital Twin: Automated Cell Type Distance Computation and 3D Atlas Construction in Multiplexed Skin Biopsies
|
cell biology
|
Nitrite lowers the oxygen cost of ATP supply in skeletal muscle cells by stimulating the rate of glycolytic ATP synthesis
|
biochemistry
|
Cellular compartmentalisation and receptor promiscuity as a strategy for accurate and robust inference of position during morphogenesis
|
biophysics
|
Liquid droplet aging and fibril formation of the stress granule protein TIA1 low complexity domain
|
biophysics
|
Behavioral and imaging analysis of Foxg1 heterozygous mice
|
neuroscience
|
S-adenosylmethionine synthases specify distinct H3K4me3 populations and gene expression patterns during heat stress
|
cell biology
|
Constitutive, calcium-independent endoplasmic reticulum-plasma membrane contact site oscillations and its implications in store-operated calcium entry
|
cell biology
|
Ancestral origins are associated with SARS-CoV-2 susceptibility and protection in a Florida patient population
|
genetics
|
High-throughput imaging and quantitative analysis uncovers the nature of plasmid positioning by ParABS
|
biophysics
|
Prediction of gene essentiality using machine learning and genome-scale metabolic models
|
systems biology
|
Evaluation of the broth microdilution methodology for susceptibility testing of Mycobacterium tuberculosis in Peru
|
microbiology
|
Influenza A virus RNA Polymerase targets the chromatin of innate immune response genes
|
molecular biology
|
Plastomes of Hyalomonas oviformis and Hyalogonium fusiforme evolved dissimilar architecture after loss of photosynthesis
|
genomics
|
WWP2 osteoarthritis risk allele rs1052429-A confers risk by affecting cartilage matrix deposition via hypoxia associated genes
|
cell biology
|
High fat diet initiates rapid adaptation of the intestine
|
cell biology
|
Microtubules self-repair in living cells
|
cell biology
|
TYMV has dual action on the plant RNA silencing defense through its VSR P69 and the host RNASE THREE LIKE1
|
plant biology
|
Structure-function conservation between the methyltransferases SETD3 and SETD6
|
cell biology
|
Computational rewiring of allosteric pathways reprograms GPCR selective responses to ligands
|
bioengineering
|
Ageing critically transforms the network connectivity and viscoelasticity of RNA-binding protein condensates but RNA can prevent it
|
biophysics
|
Effects of organic fertilizer digestate on the growth of tomato (Lycopersicon esculentum Mill)
|
plant biology
|
Neighbouring modifications interfere with the detection of phosphorylated alpha-synuclein at Serine 129: Revisiting the specificity of pS129 antibodies
|
neuroscience
|
Identification and characterization of the T cell receptor (TCR) repertoire of the Cynomolgus macaque (Macaca Fascicularis)
|
immunology
|
Resolution of glycogen and glycogen-degrading activities reveals correlates of Lactobacillus crispatus dominance in a cohort of young African women
|
microbiology
|
Hypoxia-induced tracheal elasticity in vector beetle facilitates the loading of pinewood nematode
|
ecology
|
The Role of Replication-induced Chromosomal Copy Numbers in Spatio-temporal Gene Regulation and Evolutionary Chromosome Plasticity
|
genetics
|
A divide-and-conquer approach for genomic prediction in rubber tree using machine learning
|
genetics
|
Correlation and Path Coefficient Analyses in Hot Pepper (Capsicum annum L.)
|
genetics
|
CUT&Tag recovers up to half of ENCODE ChIP-seq peaks
|
genomics
|
Gradient-k: Improving the performance of K-Means using the density gradient
|
bioinformatics
|
Deep learning to decompose macromolecules into independent Markovian domains
|
biophysics
|
Painters in chromatin: a unified quantitative framework to systematically characterize epigenome regulation and memory
|
biophysics
|
In silico analysis of Bacopa monnieri (L.) Wettst. compounds for drug development against Neurodegenerative Disorders
|
pharmacology and toxicology
|
Hypercaloric diet triggers transient molecular rearrangements of astrocytes selectively in the arcuate nucleus
|
neuroscience
|
Fear memory in humans is consolidated over time independent of sleep
|
neuroscience
|
Incertohypothalamic A13 dopaminergic neurons are involved in fine forelimb movements but not reward
|
neuroscience
|
Plant-invertebrate interactions across a forested retrogressive chronosequence
|
ecology
|
Performance and limitations of linkage-disequilibrium-basedmethods for inferring the genomic landscape of recombination anddetecting hotspots: a simulation study
|
genomics
|
Variable Selection via Grace-AKO with Applications in Genomics
|
bioinformatics
|
Contributions of the N-terminal intrinsically disordered region of the SARS-CoV-2 nucleocapsid protein to RNA-induced phase separation
|
biophysics
|
The dynamical Matryoshka model: 2. Modeling of local lipid dynamics at the sub-nanosecond timescale in phospholipid membranes
|
biophysics
|
Mapping whole-brain projections of anatomically defined prefrontal neurons using combined 3D convolution networks
|
neuroscience
|
Hierarchical architecture of dopaminergic circuits enables second-order conditioning in Drosophila
|
neuroscience
|
Fear extinction is regulated by long noncoding RNA activity at the synapse
|
neuroscience
|
Screening the Pathogen Box Compounds for Activity Against Plasmodium falciparum Sporozoite Motility
|
microbiology
|
Conformational flexibility, lipid binding, and regulatory domains in CelTOS
|
microbiology
|
Cross neutralization of Omicron BA.1 against BA.2 and BA.3 SARS-CoV-2
|
microbiology
|
Brequinar and Dipyridamole in Combination Exhibits Synergistic Antiviral Activity Against SARS-CoV-2 in vitro: Rationale for a host-acting antiviral treatment strategy for COVID-19
|
microbiology
|
Methylene blue, Mycophenolic acid, Posaconazole, and Niclosamide inhibit SARS-CoV-2Omicron variant BA.1 infection of human airway epithelial explant cultures
|
microbiology
|
Identification of C270 as a novel site for allosteric modulators of SARS-CoV-2 papain-like protease
|
molecular biology
|
An in situ cut-and-paste genome editing platform mediated by CRISPR/Cas9 or Cas12a
|
molecular biology
|
Clinical mutations in WDR34 lead to diverse impacts on the assembly and function of dynein-2
|
cell biology
|
Protein Quaternary Structures in Solution are a Mixture of Multiple forms
|
biochemistry
|
Helical remodeling augments 5-lipoxygenase activity
|
biochemistry
|
Sensitive detection and structural characterisation of UV-induced cross-links in protein-RNA complexes using CLIR-MS
|
biochemistry
|
Prediction of infectivity of SARS-CoV2: Mathematical Model with Docking Simulation analysis between Spike Protein and ACE2
|
bioinformatics
|
Model guided design of enhanced bi-stable controllers to effectively switch cellular states
|
synthetic biology
|
CIS calibrates GM-CSF signalling strength to regulate macrophage polarization via a STAT5-IRF8 axis
|
immunology
|
cGASylation by a bacterial E1-E2 fusion protein primes antiviral immune signaling
|
microbiology
|
SARS-CoV-2 Omicron is specifically restricted in its replication in human lung tissue, compared to other variants of concern
|
microbiology
|
On the relationship between Pathogenic Potential and Infective Inoculum
|
microbiology
|
Vaccination decreases the risk of influenza A virus reassortment with a concomitant increase in subgenomic genetic variation in pigs
|
microbiology
|
Small Molecules Restore Azole Activity Against Drug-Tolerant and Drug-Resistant Candida Isolates
|
microbiology
|
Ultra-deep Sequencing of Hadza Hunter-Gatherers Recovers Vanishing Microbes
|
microbiology
|
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