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Hypoxia-mediated suppression of pyruvate carboxylase drives tumor microenvironment immunosuppression
|
cancer biology
|
Identification of plasma proteins associated with oesophageal cancer chemotherapeutic treatment outcomes using SWATH-MS
|
cancer biology
|
Inhibition of mutant IDH1 promotes cycling of acute myeloid leukemia stem cells
|
cancer biology
|
Discovery of a novel mesothelin specific human antibody VH domain
|
cancer biology
|
Divergent MEK/ERK and AMPK signaling dictate lipogenic plasticity and dependence on fatty acid synthesis in Glioblastoma
|
cancer biology
|
Modelling the spatial dynamics of oncolytic virotherapy in the presence of virus-resistant tumor cells
|
cancer biology
|
RNA decay defines the therapeutic response to transcriptional perturbation in cancer
|
cancer biology
|
Mapping phenotypic heterogeneity in melanoma onto the epithelial-hybrid-mesenchymal axis
|
cancer biology
|
Propofol disrupts alpha dynamics in distinct thalamocortical networks underlying sensory and cognitive function during loss of consciousness
|
neuroscience
|
Unaltered T cell responses to common antigens in individuals with Parkinson's disease
|
immunology
|
Reactive Oxygen Species Signaling Differentially Controls Wound Healing and Regeneration
|
developmental biology
|
Epistasis between synonymous and nonsynonymous mutations in Dictyostelium discoideum ammonium transporter amtA drives functional complementation in Saccharomyces cerevisiae.
|
genetics
|
Deploying genomics workflows on high performance computing (HPC) platforms: storage, memory, and compute considerations
|
bioinformatics
|
SOX9 binds TCFs to mediate Wnt/β catenin target gene activation
|
cancer biology
|
Mathematical models of tumor volume dynamics in response to radiotherapy
|
cancer biology
|
Functional plasticity and recurrent cell states of malignant B cells in follicular lymphoma
|
cancer biology
|
Sexual dimorphism versus biomechanical loading in occipital bone morphological variation
|
physiology
|
Excess ribosomal protein production unbalances translation in Fragile X Syndrome
|
neuroscience
|
A genetic variant of the Wnt receptor LRP6 accelerates synapse degeneration during ageing and in Alzheimer's disease
|
neuroscience
|
An EcR probe reveals mechanisms of the ecdysone-mediated switch from repression-to-activation on target genes in the larval wing disc
|
developmental biology
|
Heat and humidity sensors that alert mosquitoes to nearby human hosts
|
neuroscience
|
Primary cilia loss promotes reactivation of morphogenesis and cyst-fission through a deregulated TGFβ-ECM-Integrin axis in polycystic liver disease.
|
cell biology
|
Interoperability of RTN1A in dendrite dynamics and immune functions in human Langerhans cells
|
cell biology
|
A dominant negative mutation uncovers cooperative control of caudal Wolffian Duct development by Sprouty genes
|
developmental biology
|
Hydrogens and hydrogen-bond networks in macromolecular MicroED data
|
biochemistry
|
Myosin Heavy Chain Converter Domain Mutations Drive Early-Stage Changes in Extracellular Matrix Dynamics in Hypertrophic Cardiomyopathy
|
bioengineering
|
Parallel cryo electron tomography on in situ lamellae
|
biophysics
|
Modeling and mechanical perturbations reveal how spatially regulated anchorage gives rise to spatially distinct mechanics across the mammalian spindle
|
biophysics
|
Redox regulation of yeast Hsp70 modulates protein quality control while directly triggering an Hsf1-dependent cytoprotective response
|
cell biology
|
Dictyostelium discoideum cells sense their local density and retain nutrients when the cells are about to overgrow their food source
|
cell biology
|
The HH-GLI2-CKS1B network regulates the proliferation-to-maturation transition of human cardiomyocytes
|
developmental biology
|
Trim33 conditions the lifespan of primitive macrophages and onset of definitive macrophage production
|
developmental biology
|
A Comprehensive Roadmap of Human Placental Development in vitro
|
developmental biology
|
Intraspecific diversity based on low temperature induced arrhythmia in embryonic heart of medaka (Oryzias latipes)
|
developmental biology
|
DOT1L activity affects cell lineage progression in the developing brain by controlling metabolic programs
|
developmental biology
|
Cytoneme-mediated transport of active Wnt5b/Ror2 complexes in zebrafish gastrulation
|
developmental biology
|
Cochlear Neurotrophin-3 overexpression at mid-life prevents age-related cochlear synaptopathy and slows age-related hearing loss
|
neuroscience
|
Speech Production in Intracranial Electroencephalography: iBIDS Dataset
|
neuroscience
|
Plant-produced RBD and cocktail-based vaccine candidates are highly effective against SARS-CoV-2, independently of its emerging variants
|
immunology
|
Chemical conversion of human conventional Pluripotent Stem Cells to Trophoblast Stem Cells
|
developmental biology
|
Integrating bulk and single cell RNA-seq refines transcriptomic profiles of specific C. elegans neurons.
|
genetics
|
Paired Associates Learning is Disrupted After Unilateral Parietal Lobe Controlled Cortical Impact in Rats: A Trial-by-Trial Behavioral Analysis
|
animal behavior and cognition
|
Microphysiological Drug-Testing Platform For Identifying Responses To Prodrug Treatment In Primary Leukemia
|
bioengineering
|
EcoFun-MAP: An Ecological Function Oriented Metagenomic Analysis Pipeline
|
bioinformatics
|
scROSHI - robust supervised hierarchical identification of single cells
|
bioinformatics
|
Identification and comparison of somatic antigen composition for bacteria from Providencia genus
|
bioinformatics
|
Chromenone derivatives as novel pharmacological chaperones for retinitis pigmentosa-linked rod opsin mutants
|
pharmacology and toxicology
|
Metformin disrupts Danio rerio metabolism at environmentally relevant concentrations: A generational study
|
pharmacology and toxicology
|
Isometric Spiracular Scaling in Scarab Beetles: Implications for Diffusive and Advective Oxygen Transport
|
physiology
|
A snapshot of statistical methods used in experimental immunoblotting: A scoping review
|
scientific communication and education
|
Topological Data Analysis of Human Brain Networks Through Order Statistics
|
neuroscience
|
Formalism for the sequential estimation of neural membrane time constant and input-output curve towards selective and closed-loop transcranial magnetic stimulation
|
neuroscience
|
Neuroscout, a unified platform for generalizable and reproducible fMRI research
|
neuroscience
|
High frequency spike inference with particle Gibbs sampling
|
neuroscience
|
ROStrace detects oxidative stress in vivo and predicts progression of Alzheimer's disease pathology in APP/PS1 mice.
|
neuroscience
|
The Delta variant SARS-CoV-2 spike protein uniquely promotes aggregation of pseudotyped viral particles
|
microbiology
|
Hippo Signaling Pathway Activation during SARS-CoV-2 Infection Contributes to Host Antiviral Response
|
microbiology
|
The non-random assembly of functional motifs in plant-pollinator networks
|
ecology
|
Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike
|
biochemistry
|
Design of an Integrated Microvascularised Human Skin-on-a-Chip Tissue Equivalent Model
|
bioengineering
|
Protein 3D structure-based neural networks highly improve the accuracy in compound-protein binding affinity prediction
|
bioinformatics
|
A Systematic Evaluation of the Computational Tools for Ligand-receptor-based Cell-Cell Interaction Inference
|
bioinformatics
|
A Novel Prognosis Model based on Comprehensive Analysis of Pyroptosis-Related Genes in Breast Cancer
|
bioinformatics
|
SARS-CoV-2 mutations affect proteasome processing to alter CD8+ T cell responses
|
immunology
|
SARS-CoV-2 and its variants, but not Omicron, induces thymic atrophy and impaired T cell development
|
immunology
|
Prostaglandins and calprotectin are genetically and functionally linked to the Inflammatory Bowel Diseases
|
genetics
|
D27-LIKE1 carotenoid isomerase has a preference towards trans/cis and cis/cis conversions in Arabidopsis
|
plant biology
|
NVX-CoV2373 vaccination induces functional SARS-CoV-2-specific CD4+ and CD8+ T cell responses
|
immunology
|
Oncogenic metabolic rewiring independent of proliferative control in human mammary epithelial cells
|
biochemistry
|
Recycling of Polymerase Chain Reaction (PCR) kits
|
biochemistry
|
Expression Analysis, Molecular Characterization and Prognostic Evaluation on TMED4 and TMED9 Gene Expression in Glioma
|
cancer biology
|
NF kappa B Regulator Bcl3 Controls Development and Function of Classical Dendritic Cells in Toxoplasma gondii
|
immunology
|
Gαq modulates the energy metabolism of osteoclasts
|
immunology
|
TLR2 axis on peripheral blood mononuclear cells regulates inflammatory responses to circulating, non-infectious immature dengue virus particles
|
immunology
|
Acod1 negatively impacts osteoclastogenesis via GPR91-mediated NFATc1 activation
|
immunology
|
Antibiotic-producing Micrococcales govern the microbiome that inhabits the fur of two- and three-toed sloths
|
microbiology
|
Ultra-high-throughput microbial single-cell whole genome sequencing for genome-resolved metagenomics
|
microbiology
|
Allele specific PCR for a major marker of levamisole resistance in Haemonchus contortus
|
microbiology
|
A new microfluidic device for simultaneous detection of enzyme secretion and elongation of a single hypha
|
microbiology
|
The RNA-RNA interactome between a phage and its satellite virus reveals a small RNA differentially regulates gene expression across both genomes
|
microbiology
|
Intestinal inflammation reversibly alters the microbiota to drive susceptibility to Clostridioides difficile colonization in a mouse model of colitis
|
microbiology
|
Molecular Architecture of the Chikungunya Virus Replication Complex
|
microbiology
|
A CRISPR-based instant DNA repositioning system and the early intranuclear life of HSV-1
|
microbiology
|
Hepatobiliary organoids derived from leporids support the replication of hepatotropic lagoviruses
|
microbiology
|
Pneumococcus triggers NFkB degradation in COMMD2 aggresome-like bodies.
|
microbiology
|
Dietary and Reproductive Traits of Two Brachyuran Crab Species
|
ecology
|
Wax worm saliva and the enzymes therein are the key to polyethylene degradation by Galleria mellonella
|
molecular biology
|
Soil water consumption characteristics in rain-fed apple orchards and wheat fields
|
ecology
|
Multiple lines of evidence indicate survival of the Ivory-billed Woodpecker in Louisiana
|
ecology
|
Co-Component Signal Transduction Systems: fast-evolving virulence regulation cassettes discovered in enteric bacteria
|
evolutionary biology
|
Organisation of gene programs revealed by unsupervised analysis of diverse gene-trait associations
|
genomics
|
Discovery and Visualization of Age-dependent Patterns in the Diurnal Transcriptome of Drosophila
|
systems biology
|
Structure of Importin-4 bound to the H3-H4·ASF1 histone·histone chaperone complex
|
molecular biology
|
Distal-less homeobox genes Dlx5/6 regulate Mulllerian duct regression
|
developmental biology
|
Effects of seasonal changes on the carbon dynamics in mixed coniferous forests
|
ecology
|
Different factors drive community assembly of rare and common ectomycorrhizal fungi
|
ecology
|
Inferring bound structure and residue specific contributions to binding energetics in the Intrinsically Disordered Protein, CcdA
|
biophysics
|
The natural diversity of the yeast proteome reveals chromosome-wide dosage compensation in aneuploids
|
systems biology
|
Learning and Expression of Dopaminergic Reward Prediction Error via Plastic Representations of Time
|
neuroscience
|
The Neural Response at the Fundamental Frequency of Speech is Modulated by Word-level Acoustic and Linguistic Information
|
neuroscience
|
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