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Sequential treatment of paper and pulp industrial wastewater: Prediction of water quality parameters by Mamdani Fuzzy Logic model and phytotoxicity assessment.
Recycling of industrial wastewater meeting quality standards for agricultural and industrial demands is a viable option. In this study, paper and pulp industrial wastewater were treated with three biological treatments viz. aerobic, anaerobic and sequential (i.e. 20 days of anaerobic followed by 20 days of aerobic cycle), associated with simulation modeling by Mamdani Fuzzy Logic (MFL) model of some selected parameters. Electric air diffuser and minimal salt medium in sealed plastic bottles at control temperature were used for aerobic and anaerobic treatments, respectively. The significant reduction in chemical (COD: 81%) and biological oxygen demand (BOD: 71%), total suspended (TSS: 65%), dissolved solids (TDS: 60%) and turbidity (68%) was recorded during sequential treatment. The treated water was irrigated to determine its phytotoxic effects on seed germination, vigor and seedling growth of mustard (Brassica campestris). Sequential treatment greatly reduced phytotoxicity of wastewater and showed the highest germination percentage (90%) compared to aerobic (60%), anaerobic (70%) treatments and untreated wastewater (30%). Regression analysis also endorsed these findings (R2 = 0.76-0.95 between seed germination, seedling growth and vigor). MFL technique was adopted to simulate sequential treatment process. The results support higher performance of MFL model to predict TDS, TSS, COD, and BOD based on the physico-chemical water quality parameters of raw wastewater, time of treatment and treatment type variation. Based on these findings, we conclude that the sequential treatment could be a more effective strategy for treatment of pulp and paper industrial wastewater with efficiency to be used for agricultural industry without toxic effects.
|
{
"pile_set_name": "PubMed Abstracts"
}
| 0 |
MiR-146a promotes oligodendrocyte progenitor cell differentiation and enhances remyelination in a model of experimental autoimmune encephalomyelitis.
The death of mature oligodendrocytes (OLs) leads to demyelination in the central nervous system (CNS) and subsequently to functional deficits. Remyelination requires the differentiation of oligodendrocyte progenitor cells (OPCs) into myelinating OLs, which in the CNS with neurodegenerative diseases such as multiple sclerosis (MS), is often inhibited. Among the inhibitors of OPC differentiation are toll-like receptor 2 (TLR2) and interleukin-1 receptor-associated kinase 1 (IRAK1) signaling, and both are negatively regulated by microRNA-146a (miR-146a). Therefore, we hypothesized that increase of miR-146a level in the CNS would foster OPC differentiation and remyelination by inhibiting the TLR2/IRAK1 signaling pathway. Here, we tested this hypothesis using exogenous miR-146a mimics and a mouse model of MS, experimental autoimmune encephalomyelitis (EAE) induced by immunization with myelin proteolipid protein peptide (PLP139-151). EAE mice were treated by miR-146a mimics or miR-146a mimic negative controls, respectively, which initiated at day 14 post immunization, once a week for 6 consecutive weeks. Neurological function was monitored daily. Immunofluorescent staining, qRT-PCR and Western blot were used to measure the differentiation of OPCs and myelination, and to investigate the underlying mechanisms of action of miR-146a. Using a fluorescence tracing approach, we found that miR-146a mimics crossed the blood brain barrier and targeted OPCs and microglia/macrophages after systemic administration. MiR-146a mimic treatment substantially improved neurological functional outcome, increased the number of newly generated OLs which may facilitate remyelination in the CNS. The cell number, cytokine level and protein levels of M2 phonotype of microglia/macrophages significantly increased, while cytokine and protein levels of the M1 phenotype significantly decreased after miR-146a mimic treatment. Increased OPC differentiation and remyelination were associated with reduction of TLR2/IRAK1 signaling pathway activity by miR-146a mimic treatment. This study provides insight into the cellular and molecular bases for the therapeutic effects of miR-146a on OPC differentiation and remyelination, and suggests the potential of enhancing miR-146a as a treatment of demyelinating disorders.
|
{
"pile_set_name": "PubMed Abstracts"
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| 0 |
LOS ANGELES, CA - JUNE 03: TV Personality Torrie Wilson attends the 4th annual "Ante Up For A Cancer Free Generation Poker Tournament And Casino Night" at Sofitel Los Angeles At Beverly Hills on June 3, 2017 in Los Angeles, California. (Photo by Paul Archuleta/Getty Images)
The WWE Hall of Fame class for 2019 will feature D-Generation X, which includes Chyna, and The Honky Tonk Man, and a recent report states that Torrie Wilson and Brutus “The Barber” Beefcake will join them.
Last year’s loaded WWE Hall of Fame class featured several fan favorites in Mark Henry, Ivory, Goldberg, Jeff Jarrett, and The Dudley Boyz, and the 2019 class will hopefully make just as much of an impact.
Last month, WWE announced that D-Generation X – Chyna, Triple H, Shawn Michaels, Billy Gunn, and Sean Waltman – will be inducted into the Hall of Fame this year, and it’s been a long-time coming for both Chyna and “X-Pac”. WWE also announced that The Honky Tonk Man will enter the Hall of Fame this year, which was news first broken by WrestleVotes on Twitter.
WrestleVotes has also reported that Taz and the Hart Foundation will join this year’s class
Now, WrestleVotes reports that Torrie Wilson and Brutus “The Barber” Beefcake will join this year’s Hall of Fame class:
Exclusive: HOF news…. Torrie Wilson & Brutus “The Barber” Beefcake will be inducted as part of the 2019 WWE Hall of Fame class. — WrestleVotes (@WrestleVotes) March 2, 2019
This is exciting news, as both wrestlers are legends of the business, and it’s always especially exciting to see another woman inducted into the HOF. Wrestlers like Torrie Wilson helped pave the way for the women of today, setting the table for the Women’s Evolution in WWE after slowly working towards progress, even when they were forced into degrading storylines or matches.
Wilson appeared at the 25th Anniversary of Raw last year and competed in both the first Women’s Royal Rumble match and the Battle Royal at Evolution, which was WWE’s first all-women’s Pay Per View.
That shows Wilson has still been involved in important moments in WWE, and it’s only fitting for them to honor her with a Hall of Fame induction after giving her some (all too brief) shine at the 25th Anniversary of Raw in 2018. Wilson competed in WCW in 1999 and 2000 before joining WWE, where she was a mainstream crossover star and wrestled full-time for the company from 2001 to 2008.
It would be awesome to see Wilson in the Hall of Fame, and it would be interesting to listen to the wisdom she imparts at her speech, especially since she’s done so much outside of wrestling since 2008 (though, again, she has appeared on WWE programming several times as a legend). Furthermore, I wonder who would induct Wilson, as it’s always cool to hear what peers have to say about a wrestler heading into the Hall of Fame.
|
{
"pile_set_name": "OpenWebText2"
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| 0 |
Bangladeshi intelligence community
The Bangladesh Intelligence Community is a group of several intelligence agencies charged with carrying out intelligence-gathering activities considered necessary for the conduct of foreign relations and national security of Bangladesh including other functions vital for the national security of Bangladesh. Member organizations of the Bangladesh intelligence community include military intelligence of Bangladesh Army, Navy, Air Force, National Police and civilian intelligence and analysis offices within executive ministries. The I.C. is headed by a Director heading each Intelligence agency, who reports to the Prime Minister of the Bangladesh.The organisation and structure of the modern Bangladesh intelligence community has developed its structures from agencies that continued to function after Independence from Pakistan. Bangladesh intelligence agencies today are the National Security Intelligence, the Special Branch, Army Intelligence, Air Force Intelligence, Naval Intelligence and the Directorate General of Forces Intelligence (DGFI). During the 1971 Bangladesh Independence War, the Bangladesh Forces in the 11 BDF Sectors also developed an intelligence network within its organisation of guerrilla combat teams that provided the sectors with essential local intelligence. However, the intelligence agency personnel have been and still continues to be recruited and trained from within the particular agency. Among their varied responsibilities, the members of the Community collect and produce foreign and domestic intelligence, contribute to military planning, and perform espionage.
National Security Intelligence
The National Security Intelligence, also known as the Directorate-General of National Security Intelligence is the primary intelligence agency responsible for internal security (including internal political affairs), foreign intelligence and counterintelligence. Although distinct from the Military of Bangladesh, it is sometimes led by a retired senior military officer. It reports directly to the Prime Minister of Bangladesh and is administered from the Prime Minister's Office.
Directorate General of Forces Intelligence
The Directorate General of Forces Intelligence (DGFI) is the main military intelligence outfit, responsible for intelligence gathering for all military purposes. The DGFI also includes subdivisions specifically serving the Bangladesh Army, the Bangladesh Navy and the Bangladesh Air Force, but the agency itself is distinct and unified for all military intelligence functions. It is also responsible for policing the ranks within the services in light of Bangladesh's history.
Special Branch
The Special Branch (SB) of the Bangladesh Police is the country's first intelligence agency. Major responsibilities of this branch are to meet up any intelligence required from government, registration and control of foreigners, perform verification role, give protection to the VIPs & VVIPs, intelligence gathering, immigration controls etc. This is the only intelligence outfit of Bangladesh which works in all strategic, operational and tactical levels. It reports directly to the Prime Minister of Bangladesh.
Police Bureau of Investigation
Police Bureau of Investigation is a specialized unit of Bangladesh Police. It was formed on 18 Sep 2012 to investigate "sensational" and difficult cases.
Criminal Investigation Department
CID is a specialized wing of the Bangladesh Police. It carries out investigations into crimes, including terrorism, murders and organized crime. It also gives forensic support.
References
Category:Bangladeshi intelligence agencies
Category:Law enforcement in Bangladesh
Category:Intelligence communities
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{
"pile_set_name": "Wikipedia (en)"
}
| 0 |
Thermally-induced transformation of hexabromocyclo dodecanes and isobutoxypenta bromocyclododecanes in flame-proofed polystyrene materials.
Polystyrenes (PS) are produced in quantities exceeding 10 Mt y(-1). They are used for insulation and packaging materials, often in flame-proofed forms with hexabromocyclododecanes (HBCDs) added as flame retardants. Polystyrenes are also constituents of plastic debris found in the aquatic environment. HBCDs are now considered as persistent, bioaccumulative, and toxic compounds. Lately, we reported that isobutoxypenta bromocyclododecanes (iBPBCDs), a formerly unknown class of polybrominated compounds, are also present in flame-proofed polystyrenes. It is therefore likely that iBPBCDs are released along with HBCDs from these materials. Herein, we report on changes of the HBCD- and iBPBCD-patterns when exposing expanded (EPS) and extruded (XPS) polystyrenes at temperatures of 140-160 degrees C. Substantial transformation reactions were observed in EPS, which was rich in gamma-HBCDs and delta-, eta-, and theta-iBPBCDs at the beginning, but changed to materials rich in alpha-HBCDs and alpha-, beta-, epsilon-, and xi-iBPBCDs. Patterns of untreated XPS already resembled those of the thermally treated EPS. Upon thermal exposure, some further enrichment of alpha-HBCDs and alpha-, beta-, epsilon-, and xi-iBPBCDs was also noticed for the XPS samples, indicating similar transformation mechanisms. Comparable apparent first-order transformation rate constants (k(trans)) of -0.003, -0.008, and -0.020 min(-1) and -0.004, -0.009, and -0.019 min(-1) are found for gamma-HBCD- and delta-iBPBCD-conversion at 140, 150, and 160 degrees C, respectively. We conclude that a thermal treatment of flame-proofed polystyrenes alters their HBCD- and iBPBCD-patterns. Thus depending on the proportions of EPS and XPS materials reaching the environment, more of the lipophilic (late-eluting) or of the more polar (early-eluting) HBCD- and iBPBCD-stereoisomers will be released. Several properties such as partitioning coefficients, degradation rates, and bioaccumulation factors are stereoisomer-specific. Therefore, the environmental fate of individual HBCDs and iBPBCDs is expected to vary, the specific stereoisomer pattern in polystyrenes at a potential source is another important aspect to consider.
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{
"pile_set_name": "PubMed Abstracts"
}
| 0 |
...x
..xx
x..x
x.x
.x
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{
"pile_set_name": "Github"
}
| 0.130435 |
Lelu Love-Watch Me Suck And Doggystyle Fuck In Hoodie
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{
"pile_set_name": "OpenWebText2"
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| 0.056604 |
i was a man whore
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{
"pile_set_name": "Enron Emails"
}
| 0.058824 |
On Sun, 12 Jun 2011 00:36:01 +0200
Carl-Daniel Hailfinger <c-d.hailfinger.devel.2006 at gmx.net> wrote:
> Kill the additional braces, please. I know this is a multiline
> statement, but it is only a single statement and the indentation of the
> second line makes it obvious where it belongs to.
> […]
done and committed in r1334. thank you!
--
Kind regards/Mit freundlichen Grüßen, Stefan Tauner
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{
"pile_set_name": "Pile-CC"
}
| 0 |
Methods for improving uplink (UL) coverage, throughput and transmission latency are being investigated in Release 6 (R6) of the 3rd generation partnership project (3GPP). In order to successfully implement these methods, scheduling and assigning of UL physical resources have been moved from a radio network controller (RNC) to a Node-B such that the Node-B can make decisions and manage UL radio resources on a short-term basis more efficiently than the RNC, even if the RNC retains overall control over the Node-B.
FIG. 1 is a block diagram of a conventional wireless communication system 100 configured in accordance with the present invention. The system 100 comprises a wireless transmit/receive unit (WTRU) 102, a Node-B 104 and an RNC 106. The RNC 106 controls overall enhanced uplink (EU) operation by configuring EU parameters for the Node-B 104 and the WTRU 102 such as initial transmit power level, maximum allowed EU transmit power or available channel resources per Node-B. Between the WTRU 102 and the Node-B 104, an E-DCH 108, a UL EU signaling channel 110 and a DL EU signaling channel 112 are established for supporting EU operations.
For E-DCH transmissions, the WTRU 102 sends a rate request to the Node-B 104 via the UL EU signaling channel 110. In response, the Node-B 104 sends a rate grant to the WTRU 102 via the DL EU signaling channel 112. After EU radio resources are allocated for the WTRU 102, the WTRU 102 transmits E-DCH data via the E-DCH 108. In response to the E-DCH transmissions, the Node-B 104 sends an acknowledgement (ACK) or non-acknowledgement (NACK) message for hybrid automatic repeat request (H-ARQ) operation via the DL EU signaling channel 112. The Node-B 104 may also respond with rate grants to the WTRU 102 in response to E-DCH data transmissions.
FIG. 2 is a block diagram of conventional protocol architecture of the WTRU 102. The protocol architecture of the WTRU 102 includes higher layers 202, a radio link control (RLC) layer 204, a medium access control (MAC) layer 206 and a physical layer (PHY) 208. The MAC layer 206 includes a dedicated channel MAC (MAC-d) 210 and an E-DCH MAC (MAC-e/es) 212. The MAC-e/es 212 handles all functions related to the transmission and reception of an E-DCH including, but not limited to, H-ARQ transmissions and retransmissions, priority of data, MAC-d/MAC-es multiplexing and transport format combination (TFC) selection.
One or more independent UL transmissions are processed on an E-DCH between a WTRU and a universal mobile telecommunication system (UMTS) terrestrial radio access network (UTRAN) within a common time interval. One example of this would be a MAC layer H-ARQ or a simple MAC layer automatic repeat request (ARQ) operation, where each individual transmission may require a different number of retransmissions to be successfully received by the UTRAN. This operation may result in a loss of transmission sequence at the MAC layer.
In accordance with the 3GPP standards, the transmission time interval (TTI) for the E-DCH is set to either 10 ms or 2 ms. In order to achieve a higher data rate and throughout, the operations of the E-DCH at the WTRU should be carefully designed to accommodate the required timing.
|
{
"pile_set_name": "USPTO Backgrounds"
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| 0 |
Eat Your Cum For Me Bitch Boy
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{
"pile_set_name": "OpenWebText2"
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| 0.068966 |
Crosswalk.com aims to offer the most compelling biblically-based content to Christians on their walk with Jesus. Crosswalk.com is your online destination for all areas of Christian Living – faith, family, fun, and community. Each category is further divided into areas important to you and your Christian faith including Bible study, daily devotions, marriage, parenting, movie reviews, music, news, and more.
The Privilege of Prayer
Jennifer Maggio
Jennifer Maggio is considered a leading authority on single parents and womens issues. She is an award-winning author and speaker who draws from her own experiences through abuse, homelessness, and teen pregnancy to inspire audiences everywhere. She is founder of The Life of a Single Mom Ministries and writes for dozens of publications. She has been featured with hundreds of media outlets, including The 700 Club, Daystar Television, Moody Radio, Focus on the Family, and many more. For more information, visit thelifeofasinglemom.com.
2014Dec 29
Comments
I hurriedly parked, rushed to the gym, and found a seat in the bleachers at my kids' school. The bleachers, the gym, the court – it seems to be where I, like many parents, spend much of my time these days, as I am currently parenting year-round athletes. The game was about to start, and I could not wait to see the Tigers bring home the victory. I glanced behind me and caught the eye of a fellow mom, so I went over to greet her.
“Hey Sally! Great to see you. How's it going?” I cheerfully asked.
“Things are great.” she spouted with a slight smile, somewhat hesitantly.
I knew things were not great, but I did not know the mom that well, so we made idle chit-chat for a bit. The something-is-not-right feeling would not leave me. And before I knew it, I was throwing my arm around her shoulder and giving her a big hug, telling her that she looked like she could use one. Instantly, the tears flowed. Over the next several minutes, she began to share with me a number of burdens she was carrying ,such as parenting concerns and financial decisions. As she finished, I had the privilege of grabbing her hand and praying for her specific needs.
Which one of us has not been there? Whether you are navigating through the sometimes difficult journey of parenting, educating students, or somewhere else on life's path, you have most assuredly been at that place of feeling “overwhelmed” at some point. There is a great passage of Scripture I have clung to during those very times:
“From the ends of the earth, I cry to you for help when my heart is overwhelmed. Lead me to the towering rock of safety for you are my safe refuge, a fortress where my enemies cannot reach me.” -Psalm 61:2-3 NLT
It is a great privilege to cry out to our Heavenly Father when our heart is overwhelmed and know that He is our safe refuge. He sees those times when we are exhausted and feel you we cannot press on. He sees when we have lost sleep over a difficult decision. And He is faithful to send someone at the perfect time who is honored to pray just for you.
Jennifer Maggio is considered one of the nation's leading authorities on single parents' and womens' issues. She travels the globe sharing her riveting personal story, both to encourage and equip mothers everywhere. She has been featured on hundreds of radio and television programs, including The 700 Club, Daystar TV, Moody Radio, and many more. For more information, visit http://www.thelifeofasinglemom.com.
|
{
"pile_set_name": "Pile-CC"
}
| 0 |
CYP6B cytochrome p450 monooxygenases from Papilio canadensis and Papilio glaucus: potential contributions of sequence divergence to host plant associations.
Two groups of furanocoumarin-inducible cytochrome p450 genes, the CYP6B4 group and the CYP6B17 group, characterized in two closely related tiger swallowtails, Papilio glaucus and Papilio canadensis, are induced to different extents, with generally higher levels of CYP6B transcripts in P. glaucus. To investigate the evolutionary history of these CYP6B genes in the context of their association with furanocoumarin detoxification, we isolated thirteen CYP6B genes from these species. Each of these genes contains an intron at a conserved position (1334 nucleotides from the translation start site), which varies in length due to three insertion/deletions. The proximal 5' end flanking sequence from the transcription initiation site is highly conserved (91-98% nt identity). The sequence 5' to -640 is significantly variable due largely to the presence of three insertion/deletions. The sequence at the 3' end of this region contains a putative xenobiotic response element to xanthotoxin (XRE-xan), important for basal and xanthotoxin-inducible transcription of the P. polyxenes CYP6B1v3 gene, and multiple elements known to regulate vertebrate phase I and II promoters, including an XRE-AhR (Xenobiotic Response Element to Aryl hydrocarbon Receptor), an OCT-1 element (octamer protein binding site), an ARE (Antioxidant Response Element), an EcRE (Ecdysone Response Element), and an imperfect PXR (Pregnane X Receptor) responsive element (PRE). Our analyses of CYP6B genes in these two species indicate that these genes are in an early stage of divergence and that differential exposure of these two species to chemically distinct host plants resulting from geographical isolation has had functional impacts not only on the coding regions of these genes but also on their promoter regions. Thus, changes in p450 regulation as well as catalytic activity may play a role in the evolution of host plant associations in herbivorous insects.
|
{
"pile_set_name": "PubMed Abstracts"
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| 0 |
Wife does anal sex her ass looks so nice
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{
"pile_set_name": "OpenWebText2"
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| 0.075 |
>>717369303Fuck isn't gay, its how we're made? Why don't you like holding hands with girls, kissing girls or any of that? Why are you surfing a thread filled with all butts if you're insecure in your own sexuality. Maybe you'd be happier on reddit?
>>717353398GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT
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{
"pile_set_name": "Pile-CC"
}
| 0.054258 |
Q:
HTTP not socket web requests - D
How can I make GET and POST HTTP requests? I found Socket solution, but is it all?
string host = "google.com";
ushort port = 80;
Socket listener = new TcpSocket;
assert(listener.isAlive);
listener.blocking = false;
listener.connect(new InternetAddress(host, port));
char[] msg;
char[] req = cast(char[]) "GET /search.php HTTP/1.1\r\nHost: google.com\r\n\r\n";
listener.send(req);
A:
Take a look at std.net.curl. It has get and post methods:
import std.net.curl;
auto content = get("d-lang.appspot.com/testUrl2");
// --
auto content = post("d-lang.appspot.com/testUrl2", [1,2,3,4]);
|
{
"pile_set_name": "StackExchange"
}
| 0 |
Scaling procedures in colloidal electro-optics.
In a series of recent papers, we demonstrate the possibility to use the complete electro-optic saturation curves (or arbitrary part of them) to analyse the polarization mechanisms of charged colloidal particles. Scaling of the electro-optic saturation curves by field intensity permits to find the frequency range in which the functional dependence of the effects, hence the orientation mechanism remains unchanged. Similar procedure can be applied to verify the changes of this dependence with variation of particle electric parameters. When different polarization mechanisms are involved the new scale helps their analysis. The aim of the present paper is to summarize the basic applications and advantages of the scaling method in the electro-optic investigation of charged colloids.
|
{
"pile_set_name": "PubMed Abstracts"
}
| 0 |
Q:
Regex MySQL Insert
I got these Text Lines from an MySQL Insert and want to add an ).
(2, 1, 1, '', 'xxxx', FROM_BASE64('/9j/4...kf/Z', 'xxx', 0, 'xxx', 'xxx', 'xxx', 'xxx', '', 'xxxx', '', 'xxx', 'xxx', 'xxx', 'xxx', 'xxx', 'xxx', 'xxx', 0, '', '0', 'xxx', 'xxx', 'xxx', 'xxx', 'xxx', 'xxx', 'xxx'),
I need to add an ) to every FROM_BASE64('')
So this
(2, 1, 1, '', 'xxxx', FROM_BASE64('/9j/4...kf/Z', 'xxx', 0, 'xxx', 'xxx', 'xxx', 'xxx', '', 'xxxx', '', 'xxx', 'xxx', 'xxx', 'xxx', 'xxx', 'xxx', 'xxx', 0, '', '0', 'xxx', 'xxx', 'xxx', 'xxx', 'xxx', 'xxx', 'xxx'),
Becomes this
(2, 1, 1, '', 'xxxx', FROM_BASE64('/9j/4...kf/Z'), 'xxx', 0, 'xxx', 'xxx', 'xxx', 'xxx', '', 'xxxx', '', 'xxx', 'xxx', 'xxx', 'xxx', 'xxx', 'xxx', 'xxx', 0, '', '0', 'xxx', 'xxx', 'xxx', 'xxx', 'xxx', 'xxx', 'xxx'),
The ) after the Base64 String
A:
Base64 encodings cannot contain a single quote, so this should be rather easy:
s/FROM_BASE64('[^']*'/&)/
Explanation:
'[^']*': match a single quote followed by 0 or more non-single-quote characters, followed by another single quote
&: the complete match
You can try it out online
|
{
"pile_set_name": "StackExchange"
}
| 0.050757 |
Parcas, a regulator of non-receptor tyrosine kinase signaling, acts during anterior-posterior patterning and somatic muscle development in Drosophila melanogaster.
We have isolated parcas (pcs) in a screen to identify novel regulators of muscle morphogenesis. Pcs is expressed in the ovary and oocyte during oogenesis and again in the embryo, specifically in the developing mesoderm, throughout muscle development. pcs is first required in the ovary during oogenesis for patterning and segmentation of the early Drosophila embryo due primarily to its role in the regulation of Oskar (Osk) levels. In addition to the general patterning defects observed in embryos lacking maternal contribution of pcs, these embryos show defects in Wingless (Wg) expression, causing losses of Wg-dependent cell types within the affected segment. pcs activity is required again later during embryogenesis in the developing mesoderm for muscle development. Loss and gain of function studies demonstrate that pcs is necessary at distinct times for muscle specification and morphogenesis. Pcs is predicted to be a novel regulator of non-receptor tyrosine kinase (NRTK) signaling. We have identified one target of Pcs regulation, the Drosophila Tec kinase Btk29A. While Btk29A appears to be regulated by Pcs during its early role in patterning and segmentation, it does not appear to be a major target of Pcs regulation during muscle development. We propose that Pcs fulfils its distinct roles during development by the regulation of multiple NRTKs.
|
{
"pile_set_name": "PubMed Abstracts"
}
| 0 |
Marokopa
Marokopa is a rural community in Waitomo District and Waikato Region of New Zealand. It is located close to the coast between Awakino and Kawhia Harbour. The meshblock includes the coastal township of Marokopa, at the mouth of the Marokopa River, and the south side of the small village of Awamarino, about upstream.
The area was settled by forestry workers in the 19th century. It has been predominantly a farming locale since the early 20th century. In 1911 a large dairy factory was built, which mainly made butter which was shipped to Auckland. The Awamarino factory was enlarged in 1932, but closed in 1937. A telephone link to Te Kuiti was completed in 1914 and a service car ran on Tuesdays and Fridays from 1920. The town also had a post office, a flaxmill and a school (1908-1982). The nearest school is now Piripiri, upstream. There is a campground.
Demographics
Meshblock 1019000 had these census results -
Marokopa statistical area unit covers the area west of Te Kuiti and Piopio and between Tirua Point and Kawhia Harbour, including Taharoa and Waitomo. It had 1,539 people in 2013.
Geology
The coast between Marokopa and Kiritehere is accessible at low tide. Along the few kilometres, a succession of Late Triassic and Jurassic rocks are exposed. They are part of the western limb of the Kawhia Syncline, which extends north to the Hakarimatas and have been described as the best Triassic sequence in the North Island. The rocks are youngest at Marokopa (Aratauran) and oldest to the south of Kiritehere (Otapirian), where there is a large bed of monotis, one of the index fossils.
Marae
Marokopa Marae and Miromiro i te Pō meeting house are a meeting ground for the local Maniapoto hapū of Kinohaku, Te Kanawa and Peehi.
References
Category:Populated places in Waikato
Category:Waitomo District
|
{
"pile_set_name": "Wikipedia (en)"
}
| 0 |
>>683028214GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT
GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE FUCK OUT OF /b/ FUCKING FAGGOT GET THE UCK OUT OF /b/ FUCKING FAGGOT
>>683030117Quick piece of advice:You can only make 1 account per phone number and anyone who installs the app and has you phone number in their address book will see you.Just in case you choose a furry avatar. (I love mine too much to take it off. Though I'm sure I'll regret it when someone in my family gets the app)
>>683030163I meeaaanHow else am I supposed to properly stalk people?These threads are kinda happy for once so I downloaded it again and I'm not surprised>>683030225UhUhKindaFor youI visit 80 here every once in a while
>>683030803Ya, I had some "Internet friends" from several years back invite me to a chat. And I'm like "fuck it, they can put up with my furry avatar".It was actually kind of funny when I was being facetious about them hating me for it and they were going overboard trying to tell me it's ok, haha.
>>683030514I also have PBR and am doneWell not really, but almost>>683030467HeyyyyyNone of these are waves have a hug>>683030648Aw thanksI guess it's good to be overt sometimes >>683030771Nah it's not really even yoursYou sit here and wait for life, if that means anything>>683030801Hey boy0
>>683031441NopeSwear to God I'm an esoteric motherfucker>>683031445I'm not in Michigan and hope to stay that way>>683031664YepIt's kinda nice to know you can drop in on your internet buds tho>>683031782You hugged a stalkerThat's really weird
All trademarks and copyrights on this page are owned by their respective parties. Images uploaded are the responsibility of the Poster. Comments are owned by the Poster.
This is a 4chan archive - all of the content originated from them. If you need IP information for a Poster - you need to contact them. This website shows only archived content.
If a post contains personal/copyrighted/illegal content you can contact me at [email protected] with that post and thread number and it will be removed as soon as possible.
|
{
"pile_set_name": "Pile-CC"
}
| 0.051327 |
Fath-e Maqsud
Fath-e Maqsud (, also Romanized as Fatḩ-e Maqşūd) is a village in Gerdeh Rural District, in the Central District of Namin County, Ardabil Province, Iran. At the 2006 census, its population was 48, in 8 families.
References
Category:Towns and villages in Namin County
|
{
"pile_set_name": "Wikipedia (en)"
}
| 0 |
Suboptimal contrast opacification of dynamic head and neck MR angiography due to venous stasis and reflux: technical considerations for optimization.
Contrast-enhanced head and neck MRA may be degraded by venous stasis and reflux of contrast into the jugular veins. The purpose of this study was to evaluate the relationship between venous stasis and reflux and the side of injection and other causal factors. One hundred twenty-six consecutive patients (94 males and 32 females) who underwent contrast-enhanced MRA were evaluated for the side of contrast injection (left, n = 65; right, n = 61), hypertension, and cardiac disease. The retrosternal space was measured in all patients with left-arm injections. Eight patients (6.34%) had reflux into the jugular veins. The difference in the mean ages of patients with and without reflux was not significant (P = .069). There was a significant difference in the incidence of systemic hypertension in patients with (77.78%) and without reflux (23.73%; P = .007). There was no significant difference in the incidence of cardiac disease in patients with and without reflux (P = .323). The difference in the side of injection in patients with and without reflux (P = .005) and the difference in the mean retrosternal distance in the patients with left-arm injection with (7.2 mm) and without reflux (12.1 mm) were statistically significant (P < .001). Compression of the left brachiocephalic vein between the sternum and a tortuous aorta and proximal vessels may lead to venous reflux that can degrade the quality of contrast-enhanced MRA. Our study suggests that venous reflux can be avoided by routinely injecting right-sided veins.
|
{
"pile_set_name": "PubMed Abstracts"
}
| 0 |
Scheider, 37, will leave the series a two-time champion, having amassed seven wins and 24 podiums since his debut back in 2000.
While he represented Opel in 2000-2004, all of his wins and podiums came after his switch to Audi in 2006 following a one-year hiatus.
He won the drivers' title for the Ingolstadt marque in 2008 and doubled up in 2009.
Scheider, who also has wins in the 24 Hours of Spa and 24 Hours of Nurburgring, announced his decision to leave the DTM in a press conference late Saturday at Hockenheim, the track that played host to his most recent category win last year.
He is the third current DTM driver to confirm that he is parting ways with the series after 2016, joining fellow German veteran Martin Tomczyk and Portugal's Antonio Felix da Costa in doing so.
|
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| 0 |
SEXY MILF FUCKS AND SUCK HER BOYFRIENDS COCK AFTER HE GETS OUT OF THE SHOWE
|
{
"pile_set_name": "OpenWebText2"
}
| 0.053333 |
L'utilisation grandissante des bloqueurs de publicité inquiète les éditeurs de contenus sur Internet, privés d'une partie de leurs revenus. Quentin Hugon / Le Monde
Brendan Eich ne veut rien de moins que « réparer le Web ». L’inventeur du JavaScript, le langage informatique utilisé sur le Web, et cofondateur de Mozilla, l’organisation à l’origine de Firefox, a lancé mercredi 20 janvier une toute première version d’un nouveau navigateur, baptisé Brave. Son objectif : s’attaquer à la publicité, ou tout du moins à certaines de ses formes en ligne, qui collectent des données sur les internautes et ralentissent le chargement des pages Web.
Brave inclut par défaut un bloqueur de publicités, qui s’attaquera aussi directement à certains cookies – des fichiers déposés dans le navigateur d’un internaute et qui mémorisent des informations le concernant. Mais toutes les publicités ne seront pas supprimées : celles qui « correspondent à nos critères de qualité [non intrusives, pas de trackers…] » pourront apparaître, peut-on lire sur le site du navigateur. Des critères qui ressemblent à ceux appliqués par le controversé bloqueur de publicités Adblock Plus.
Lire : Comment notre ordinateur nous manipule
Revenus partagés
Mais, surtout, Brave ne se contentera pas de bloquer les publicités… il en remplacera une partie avec d’autres, qu’il aura lui-même choisies. C’est là que repose le système économique de ce navigateur gratuit, sous licence open source. « Nous réduisons le nombre de publicités reçues par l’utilisateur et augmentons leur qualité et leur pertinence, tout en bloquant les trackers qui espionnent vos activités sur différents sites », explique l’entreprise.
Les revenus issus de ces publicités « propres » seront partagés entre les éditeurs des sites sur lesquels elles apparaîtront et Brave, assure M. Eich. Mais aussi avec les utilisateurs du navigateur, qui disposeront d’une somme en bitcoins, cette monnaie anonyme et décentralisée, qu’ils pourront allouer aux sites de leur choix.
Concrètement, les utilisateurs de Brave auront entièrement la main sur la présence ou non de publicité sur leur navigateur : ils pourront décider de toutes les bloquer, d’en accepter sur certains sites particuliers, et de refuser celles de remplacement proposées par Brave. En revanche, s’ils les acceptent, ils pourront se servir de l’argent ainsi récolté pour donner un coup de pouce financier à leurs sites préférés. Brave promet de ne pas stocker les données de ses utilisateurs « sans leur permission ».
La guerre des bloqueurs de pub
Disponible pour Windows, Mac, Linux, iOS et Android, Brave en est encore à ses balbutiements : sa première version est destinée aux développeurs, afin qu’ils contribuent à son amélioration. L’entreprise promet néanmoins un navigateur bien plus rapide que ses concurrents, grâce à cet allégement publicitaire.
« Nous construisons une solution conçue pour éviter la guerre », justifie Brendan Eich. Les bloqueurs de publicités font, en effet, l’objet d’un débat enflammé depuis des années, ravivé en 2015 par leur arrivée dans l’iOS 9 d’Apple, le système d’exploitation de l’entreprise à la pomme. De nombreux éditeurs de site se plaignent de l’utilisation grandissante de ces « adblockers » , qui les privent d’une partie de leurs revenus, et dont le modèle économique est parfois opaque.
Lire aussi La grande guerre des bloqueurs de publicité
Le Monde
|
{
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| 0 |
/* MN10300 MMU context management
*
* Copyright (C) 2007 Red Hat, Inc. All Rights Reserved.
* Modified by David Howells (dhowells@redhat.com)
* - Derived from include/asm-m32r/mmu_context.h
*
* This program is free software; you can redistribute it and/or
* modify it under the terms of the GNU General Public Licence
* as published by the Free Software Foundation; either version
* 2 of the Licence, or (at your option) any later version.
*
*
* This implements an algorithm to provide TLB PID mappings to provide
* selective access to the TLB for processes, thus reducing the number of TLB
* flushes required.
*
* Note, however, that the M32R algorithm is technically broken as it does not
* handle version wrap-around, and could, theoretically, have a problem with a
* very long lived program that sleeps long enough for the version number to
* wrap all the way around so that its TLB mappings appear valid once again.
*/
#ifndef _ASM_MMU_CONTEXT_H
#define _ASM_MMU_CONTEXT_H
#include <linux/atomic.h>
#include <asm/pgalloc.h>
#include <asm/tlbflush.h>
#include <asm-generic/mm_hooks.h>
#define MMU_CONTEXT_TLBPID_NR 256
#define MMU_CONTEXT_TLBPID_MASK 0x000000ffUL
#define MMU_CONTEXT_VERSION_MASK 0xffffff00UL
#define MMU_CONTEXT_FIRST_VERSION 0x00000100UL
#define MMU_NO_CONTEXT 0x00000000UL
#define MMU_CONTEXT_TLBPID_LOCK_NR 0
#define enter_lazy_tlb(mm, tsk) do {} while (0)
static inline void cpu_ran_vm(int cpu, struct mm_struct *mm)
{
#ifdef CONFIG_SMP
cpumask_set_cpu(cpu, mm_cpumask(mm));
#endif
}
static inline bool cpu_maybe_ran_vm(int cpu, struct mm_struct *mm)
{
#ifdef CONFIG_SMP
return cpumask_test_and_set_cpu(cpu, mm_cpumask(mm));
#else
return true;
#endif
}
#ifdef CONFIG_MN10300_TLB_USE_PIDR
extern unsigned long mmu_context_cache[NR_CPUS];
#define mm_context(mm) (mm->context.tlbpid[smp_processor_id()])
/**
* allocate_mmu_context - Allocate storage for the arch-specific MMU data
* @mm: The userspace VM context being set up
*/
static inline unsigned long allocate_mmu_context(struct mm_struct *mm)
{
unsigned long *pmc = &mmu_context_cache[smp_processor_id()];
unsigned long mc = ++(*pmc);
if (!(mc & MMU_CONTEXT_TLBPID_MASK)) {
/* we exhausted the TLB PIDs of this version on this CPU, so we
* flush this CPU's TLB in its entirety and start new cycle */
local_flush_tlb_all();
/* fix the TLB version if needed (we avoid version #0 so as to
* distingush MMU_NO_CONTEXT) */
if (!mc)
*pmc = mc = MMU_CONTEXT_FIRST_VERSION;
}
mm_context(mm) = mc;
return mc;
}
/*
* get an MMU context if one is needed
*/
static inline unsigned long get_mmu_context(struct mm_struct *mm)
{
unsigned long mc = MMU_NO_CONTEXT, cache;
if (mm) {
cache = mmu_context_cache[smp_processor_id()];
mc = mm_context(mm);
/* if we have an old version of the context, replace it */
if ((mc ^ cache) & MMU_CONTEXT_VERSION_MASK)
mc = allocate_mmu_context(mm);
}
return mc;
}
/*
* initialise the context related info for a new mm_struct instance
*/
static inline int init_new_context(struct task_struct *tsk,
struct mm_struct *mm)
{
int num_cpus = NR_CPUS, i;
for (i = 0; i < num_cpus; i++)
mm->context.tlbpid[i] = MMU_NO_CONTEXT;
return 0;
}
/*
* after we have set current->mm to a new value, this activates the context for
* the new mm so we see the new mappings.
*/
static inline void activate_context(struct mm_struct *mm)
{
PIDR = get_mmu_context(mm) & MMU_CONTEXT_TLBPID_MASK;
}
#else /* CONFIG_MN10300_TLB_USE_PIDR */
#define init_new_context(tsk, mm) (0)
#define activate_context(mm) local_flush_tlb()
#endif /* CONFIG_MN10300_TLB_USE_PIDR */
/**
* destroy_context - Destroy mm context information
* @mm: The MM being destroyed.
*
* Destroy context related info for an mm_struct that is about to be put to
* rest
*/
#define destroy_context(mm) do {} while (0)
/**
* switch_mm - Change between userspace virtual memory contexts
* @prev: The outgoing MM context.
* @next: The incoming MM context.
* @tsk: The incoming task.
*/
static inline void switch_mm(struct mm_struct *prev, struct mm_struct *next,
struct task_struct *tsk)
{
int cpu = smp_processor_id();
if (prev != next) {
#ifdef CONFIG_SMP
per_cpu(cpu_tlbstate, cpu).active_mm = next;
#endif
cpu_ran_vm(cpu, next);
PTBR = (unsigned long) next->pgd;
activate_context(next);
}
}
#define deactivate_mm(tsk, mm) do {} while (0)
#define activate_mm(prev, next) switch_mm((prev), (next), NULL)
#endif /* _ASM_MMU_CONTEXT_H */
|
{
"pile_set_name": "Github"
}
| 0 |
COMPILATION OF ANAL CREAMPIE ORAL CREAMPIE AND CUM ON FEET
|
{
"pile_set_name": "OpenWebText2"
}
| 0.068966 |
Rosochackie
Rosochackie () is a village in the administrative district of Gmina Olecko, within Olecko County, Warmian-Masurian Voivodeship, in northern Poland. It lies approximately west of Olecko and east of the regional capital Olsztyn.
References
Rosochackie
|
{
"pile_set_name": "Wikipedia (en)"
}
| 0 |
Busty Sara in pink panties on the bed
|
{
"pile_set_name": "OpenWebText2"
}
| 0.054054 |
Q:
page based application overload memory ARC don´t release pages
may you can help me with this memory issue. So I builded a app based on the project preset "Page-Based Application" everything works well, but over time the single views load every Viewcontroller into the physical memory and don´t release them. If the memory is full the app will crash.
here ist my code:
The RootViewController (CatalougeViewController):
import UIKit
class CatalougeViewController: UIViewController, UIPageViewControllerDelegate, UIGestureRecognizerDelegate {
var pageViewController: UIPageViewController?
var zoomTransform: CGAffineTransform?
override func viewDidLoad() {
super.viewDidLoad()
// Do any additional setup after loading the view, typically from a nib.
// Configure the page view controller and add it as a child view controller.
self.pageViewController = UIPageViewController(transitionStyle: .PageCurl, navigationOrientation: .Horizontal, options: nil)
self.pageViewController!.delegate = self
let startingViewController: DataViewController = self.modelController.viewControllerAtIndex(0, storyboard: self.storyboard!)!
let viewControllers = [startingViewController]
self.pageViewController!.setViewControllers(viewControllers, direction: .Forward, animated: true, completion: {done in })
self.pageViewController!.dataSource = self.modelController
self.addChildViewController(self.pageViewController!)
self.view.addSubview(self.pageViewController!.view)
// Set the page view controller's bounds using an inset rect so that self's view is visible around the edges of the pages.
var pageViewRect = self.view.bounds
if UIDevice.currentDevice().userInterfaceIdiom == .Pad {
pageViewRect = CGRectInset(pageViewRect, 0.0, 0.0)
}
self.pageViewController!.view.frame = pageViewRect
self.pageViewController!.didMoveToParentViewController(self)
/*
// Add the page view controller's gesture recognizers to the book view controller's view so that the gestures are started more easily.
self.view.gestureRecognizers = self.pageViewController!.gestureRecognizers
*/
self.view.gestureRecognizers = self.pageViewController?.gestureRecognizers
let pinchRecognizer = UIPinchGestureRecognizer(target: self, action: "pinchDetected:")
self.view.addGestureRecognizer(pinchRecognizer)
let panRecognizer = UIPanGestureRecognizer(target: self, action: "handlePan:")
panRecognizer.minimumNumberOfTouches = 2
panRecognizer.maximumNumberOfTouches = 2
self.view.addGestureRecognizer(panRecognizer)
}
func pinchDetected(pinchRecognizer: UIPinchGestureRecognizer) {
if (UIGestureRecognizerState.Began == pinchRecognizer.state) || (UIGestureRecognizerState.Changed == pinchRecognizer.state) {
// Use the x or y scale, they should be the same for typical zooming (non-skewing)
let curScale = pinchRecognizer.view!.layer.valueForKeyPath("transform.scale.x")!.floatValue
let currentScale = CGFloat(curScale!)
// Variables to adjust the max/min values of zoom
let minScale: CGFloat = 1.0;
let maxScale: CGFloat = 2.0;
let zoomSpeed: CGFloat = 0.5;
var deltaScale: CGFloat = pinchRecognizer.scale
// You need to translate the zoom to 0 (origin) so that you
// can multiply a speed factor and then translate back to "zoomSpace" around 1
deltaScale = ((deltaScale - 1) * zoomSpeed) + 1
// Limit to min/max size (i.e maxScale = 2, current scale = 2, 2/2 = 1.0)
// A deltaScale is ~0.99 for decreasing or ~1.01 for increasing
// A deltaScale of 1.0 will maintain the zoom size
deltaScale = min(deltaScale, maxScale / currentScale)
deltaScale = max(deltaScale, minScale / currentScale)
zoomTransform = CGAffineTransformScale(pinchRecognizer.view!.transform, deltaScale, deltaScale);
pinchRecognizer.view!.transform = zoomTransform!;
// Reset to 1 for scale delta's
// Note: not 0, or we won't see a size: 0 * width = 0
pinchRecognizer.scale = 1;
}
}
func handlePan(recognizer:UIPanGestureRecognizer) {
let translation = recognizer.translationInView(self.view)
if let view = recognizer.view {
view.center = CGPoint(x:view.center.x + translation.x,
y:view.center.y + translation.y)
}
recognizer.setTranslation(CGPointZero, inView: self.view)
if recognizer.state == UIGestureRecognizerState.Ended {
// 1
let velocity = recognizer.velocityInView(self.view)
let magnitude = sqrt((velocity.x * velocity.x) + (velocity.y * velocity.y))
let slideMultiplier = magnitude / 200
// print("magnitude: \(magnitude), slideMultiplier: \(slideMultiplier)")
// 2
let slideFactor = 0.1 * slideMultiplier //Increase for more of a slide
// 3
var finalPoint = CGPoint(x:recognizer.view!.center.x + (velocity.x * slideFactor),
y:recognizer.view!.center.y + (velocity.y * slideFactor))
// 4
finalPoint.x = min(max(finalPoint.x, 0), self.view.bounds.size.width)
finalPoint.y = min(max(finalPoint.y, 0), self.view.bounds.size.height)
// 5
UIView.animateWithDuration(Double(slideFactor),
delay: 0,
// 6
options: UIViewAnimationOptions.CurveEaseOut,
animations: {recognizer.view!.center = finalPoint },
completion: nil)
}
}
override func didReceiveMemoryWarning() {
super.didReceiveMemoryWarning()
// Dispose of any resources that can be recreated.
}
var modelController: CatalougeViewControllerModel {
// Return the model controller object, creating it if necessary.
// In more complex implementations, the model controller may be passed to the view controller.
if _modelController == nil {
_modelController = CatalougeViewControllerModel()
}
return _modelController!
}
var _modelController: CatalougeViewControllerModel? = nil
// MARK: - UIPageViewController delegate methods
func pageViewController(pageViewController: UIPageViewController, spineLocationForInterfaceOrientation orientation: UIInterfaceOrientation) -> UIPageViewControllerSpineLocation {
if (orientation == .Portrait) || (orientation == .PortraitUpsideDown) || (UIDevice.currentDevice().userInterfaceIdiom == .Phone) {
// In portrait orientation or on iPhone: Set the spine position to "min" and the page view controller's view controllers array to contain just one view controller. Setting the spine position to 'UIPageViewControllerSpineLocationMid' in landscape orientation sets the doubleSided property to true, so set it to false here.
let currentViewController = self.pageViewController!.viewControllers![0]
let viewControllers = [currentViewController]
self.pageViewController!.setViewControllers(viewControllers, direction: .Forward, animated: true, completion: {done in })
self.pageViewController!.doubleSided = false
return .Min
}
// In landscape orientation: Set set the spine location to "mid" and the page view controller's view controllers array to contain two view controllers. If the current page is even, set it to contain the current and next view controllers; if it is odd, set the array to contain the previous and current view controllers.
let currentViewController = self.pageViewController!.viewControllers![0] as! DataViewController
var viewControllers: [UIViewController]
let indexOfCurrentViewController = self.modelController.indexOfViewController(currentViewController)
if (indexOfCurrentViewController == 0) || (indexOfCurrentViewController % 2 == 0) {
let nextViewController = self.modelController.pageViewController(self.pageViewController!, viewControllerAfterViewController: currentViewController)
viewControllers = [currentViewController, nextViewController!]
} else {
let previousViewController = self.modelController.pageViewController(self.pageViewController!, viewControllerBeforeViewController: currentViewController)
viewControllers = [previousViewController!, currentViewController]
}
self.pageViewController!.setViewControllers(viewControllers, direction: .Forward, animated: true, completion: {done in })
return .Mid
}
}
Thats the ViewControllerModel (CatalougeViewControllerModel):
class CatalougeViewControllerModel: NSObject, UIPageViewControllerDataSource {
override init() {
super.init()
}
func viewControllerAtIndex(index: Int, storyboard: UIStoryboard) -> DataViewController? {
// Return the data view controller for the given index.
if (PDF3.imagePath.count == 0) || (index >= PDF3.imagePath.count) {
return nil
}
// Create a new view controller and pass suitable data.
let dataViewController = storyboard.instantiateViewControllerWithIdentifier("DataViewController") as! DataViewController
dataViewController.dataObject = PDF3.imagePath[index]
return dataViewController
}
func indexOfViewController(viewController: DataViewController) -> Int {
// Return the index of the given data view controller.
// For simplicity, this implementation uses a static array of model objects and the view controller stores the model object; you can therefore use the model object to identify the index.
return PDF3.imagePath.indexOf(viewController.dataObject!) ?? NSNotFound
}
// MARK: - Page View Controller Data Source Seiten werden hochgezählt
func pageViewController(pageViewController: UIPageViewController, viewControllerBeforeViewController viewController: UIViewController) -> UIViewController? {
var index = self.indexOfViewController(viewController as! DataViewController)
if (index == 0) || (index == NSNotFound) {
return nil
}
index--
return self.viewControllerAtIndex(index, storyboard: viewController.storyboard!)
}
func pageViewController(pageViewController: UIPageViewController, viewControllerAfterViewController viewController: UIViewController) -> UIViewController? {
var index = self.indexOfViewController(viewController as! DataViewController)
if index == NSNotFound {
return nil
}
index++
if index == PDF3.imagePath.count {
return nil
}
return self.viewControllerAtIndex(index, storyboard: viewController.storyboard!)
}
}
Thank you for your time to help me...
A:
I fixed my problem. So sorry guys the solution was in the DataViewController and I doesn´t posted my DataViewController file so anyway.
Here is my solution:
old DataViewController:
import UIKit
class DataViewController: UIViewController {
@IBOutlet weak var myImageView: UIImageView!
var dataObject: String?
override func viewDidLoad() {
super.viewDidLoad()
self.myImageView.image = UIImage(named: dataObject!)
// my Images was cached because I used "named:"
}
override func didReceiveMemoryWarning() {
super.didReceiveMemoryWarning()
// Dispose of any resources that can be recreated.
}
}
Thats the new DataViewController:
import UIKit
class DataViewController: UIViewController {
@IBOutlet weak var myImageView: UIImageView!
var dataObject: String?
override func viewDidLoad() {
super.viewDidLoad()
autoreleasepool { () -> () in
self.myImageView.image = UIImage(contentsOfFile: dataObject!) // with "contentsOfFile:" the images are uncached...
}
}
override func didReceiveMemoryWarning() {
super.didReceiveMemoryWarning()
// Dispose of any resources that can be recreated.
}
}
|
{
"pile_set_name": "StackExchange"
}
| 0 |
Hillary Scott Needs Spunk In Her Butt
|
{
"pile_set_name": "OpenWebText2"
}
| 0.054054 |
whew! i cannot top wednesday’s papier-mâché bowls post (thanks, anna, for submitting my little project to craft zine!), so i’ll just bow out gracefully for the week, leaving you with a picture for s t i l l of yesterday’s lunch at moose & sadie’s. i wish all of you a wonderful, creative weekend. new posts are in the works, i’ll be back next week!
|
{
"pile_set_name": "Pile-CC"
}
| 0 |
zzz
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xxx
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|
{
"pile_set_name": "Github"
}
| 0.125 |
erotic literature
|
{
"pile_set_name": "Github"
}
| 0.055556 |
Sex Crazed Milf
Busty Sex Crazed Milf Sophie Anderson gets her Tight Ass DAP’ed by 3 Cocks (Legal porno, Focus)
|
{
"pile_set_name": "OpenWebText2"
}
| 0.071429 |
xp 10 15
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|
{
"pile_set_name": "Github"
}
| 0.058824 |
This invention relates to a contactless power supply system, with inductive wires along a traveling path of a moving object. The inductive wires operate at a predetermined frequency under an alternating current (AC) power supply. The moving object has a built-in power inducing coil coupled to the inductive wires. The power inducing coil in the moving object induces energy for supplying to a power consuming load.
An example of a conventional contactless power supply system, comprises a power supply device limiting current into inductive wires to a fixed current value, as disclosed in Japan publication No. 10-174206.
The power supply device cited comprises, a current converter powered by the inductive wires outputting a fixed high frequency current, a control amplifier controlling the current (wire current) to the inductive wires, a pulse width modulation (PWM) circuit acting as a switching device regulating wire current and frequency with the output value of the controller amplifier, and a gate driving circuit. The power supply device with an equivalent circuit employs the wire current value as the control decision current. Moreover, capacitors connected in parallel to the power supply rails result in a resonant circuit.
However, in the conventional contactless power supply system, the inductive wires provide minimal impedance, hence the load fluctuation in the inductive wires produces a significant change in the wire current. As load decreases and the current varies significantly, the control decision current may diverge to an uncontrollable degree.
|
{
"pile_set_name": "USPTO Backgrounds"
}
| 0 |
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<h1>libc++ C++1Y Status</h1>
<!--*********************************************************************-->
<p>In April 2013, the C++ standard committee approved the draft for the next version of the C++ standard, known as "C++1Y" (probably to be C++14)</p>
<p>The draft standard includes papers and issues that were voted on at the previous three meetings (Kona, Portland, and Bristol)</p>
<p>This page shows the status of libc++; the status of clang's support of the language features is <a href="http://clang.llvm.org/cxx_status.html">here</a>.</p>
<p>The groups that have contributed papers:
<ul>
<li>CWG - Core Language Working group</li>
<li>LWG - Library working group</li>
<li>SG1 - Study group #1 (Concurrency working group)</li>
</ul>
</p>
<h3>Paper Status</h3>
<table id="papers" border="1">
<tr><th>Paper #</th><th>Group</th><th>Paper Name</th><th>Meeting</th><th>Status</th><th>First released version</th></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/papers/2012/n3346.pdf">3346</a></td><td>LWG</td><td>Terminology for Container Element Requirements - Rev 1</td><td>Kona</td><td>Complete</td><td>3.4</td></tr>
<tr><td></td><td></td><td></td><td></td><td></td><td></td></tr>
<!-- <tr><td>3323</td><td>CWG</td><td>A Proposal to Tweak Certain C++ Contextual Conversions, v3</td><td>Portland</td><td></td><td></td></tr> -->
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/papers/2012/n3421.htm">3421</a></td><td>LWG</td><td>Making Operator Functors greater<></td><td>Portland</td><td>Complete</td><td>3.4</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/papers/2012/n3462.html">3462</a></td><td>LWG</td><td>std::result_of and SFINAE</td><td>Portland</td><td>Complete</td><td>3.4</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/papers/2012/n3469.html">3469</a></td><td>LWG</td><td>Constexpr Library Additions: chrono, v3</td><td>Portland</td><td>Complete</td><td>3.4</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/papers/2012/n3470.html">3470</a></td><td>LWG</td><td>Constexpr Library Additions: containers, v2</td><td>Portland</td><td>Complete</td><td>3.4</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/papers/2012/n3471.html">3471</a></td><td>LWG</td><td>Constexpr Library Additions: utilities, v3</td><td>Portland</td><td>Complete</td><td>3.4</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/papers/2011/n3302.html">3302</a></td><td>LWG</td><td>Constexpr Library Additions: complex, v2</td><td>Portland</td><td>Complete</td><td>3.4</td></tr>
<tr><td></td><td></td><td></td><td></td><td></td><td></td></tr>
<!-- <tr><td>3472</td><td>CWG</td><td>Binary Literals in the C++ Core Language</td><td>Bristol</td><td></td><td></td></tr> -->
<!-- <tr><td>3624</td><td>CWG</td><td>Core Issue 1512: Pointer comparison vs qualification conversions (revision 3)</td><td>Bristol</td><td></td><td></td></tr> -->
<!-- <tr><td>3639</td><td>CWG</td><td>Runtime-sized arrays with automatic storage duration (revision 5)</td><td>Bristol</td><td></td><td></td></tr> -->
<!-- <tr><td>3638</td><td>CWG</td><td>Return type deduction for normal functions</td><td>Bristol</td><td></td><td></td></tr> -->
<!-- <tr><td>3648</td><td>CWG</td><td>Wording Changes for Generalized Lambda-capture</td><td>Bristol</td><td></td><td></td></tr> -->
<!-- <tr><td>3653</td><td>CWG</td><td>Member initializers and aggregates</td><td>Bristol</td><td></td><td></td></tr> -->
<!-- <tr><td>3667</td><td>CWG</td><td>Drafting for Core 1402</td><td>Bristol</td><td></td><td></td></tr> -->
<!-- <tr><td>3652</td><td>CWG</td><td>Relaxing constraints on constexpr functions" and "constexpr member functions and implicit const</td><td>Bristol</td><td></td><td></td></tr> -->
<!-- <tr><td>3664</td><td>CWG</td><td>Clarifying Memory Allocation</td><td>Bristol</td><td></td><td></td></tr> -->
<!-- <tr><td>3651</td><td>CWG</td><td>Variable Templates (Revision 1)</td><td>Bristol</td><td></td><td></td></tr> -->
<!-- <tr><td>3649</td><td>CWG</td><td>Generic (Polymorphic) Lambda Expressions (Revision 3)</td><td>Bristol</td><td></td><td></td></tr> -->
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/papers/2013/n3545.pdf">3545</a></td><td>LWG</td><td>An Incremental Improvement to integral_constant</td><td>Bristol</td><td>Complete</td><td>3.4</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/papers/2013/n3644.pdf">3644</a></td><td>LWG</td><td>Null Forward Iterators</td><td>Bristol</td><td>Complete</td><td>3.4</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/papers/2013/n3668.html">3668</a></td><td>LWG</td><td>std::exchange()</td><td>Bristol</td><td>Complete</td><td>3.4</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/papers/2013/n3658.html">3658</a></td><td>LWG</td><td>Compile-time integer sequences</td><td>Bristol</td><td>Complete</td><td>3.4</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/papers/2013/n3670.html">3670</a></td><td>LWG</td><td>Addressing Tuples by Type</td><td>Bristol</td><td>Complete</td><td>3.4</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/papers/2013/n3671.html">3671</a></td><td>LWG</td><td>Making non-modifying sequence operations more robust</td><td>Bristol</td><td>Complete</td><td>3.4</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/papers/2013/n3656.htm">3656</a></td><td>LWG</td><td>make_unique</td><td>Bristol</td><td>Complete</td><td>3.4</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/papers/2013/n3654.html">3654</a></td><td>LWG</td><td>Quoted Strings</td><td>Bristol</td><td>Complete</td><td>3.4</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/papers/2013/n3642.pdf">3642</a></td><td>LWG</td><td>User-defined Literals</td><td>Bristol</td><td>Complete</td><td>3.4</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/papers/2013/n3655.pdf">3655</a></td><td>LWG</td><td>TransformationTraits Redux (excluding part 4)</td><td>Bristol</td><td>Complete</td><td>3.4</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/papers/2013/n3657.htm">3657</a></td><td>LWG</td><td>Adding heterogeneous comparison lookup to associative containers</td><td>Bristol</td><td>Complete</td><td>3.4</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/papers/2013/n3672.html">3672</a></td><td>LWG</td><td>A proposal to add a utility class to represent optional objects</td><td>Bristol</td><td><I>Removed from Draft Standard</I></td><td>n/a</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/papers/2013/n3669.pdf">3669</a></td><td>LWG</td><td>Fixing constexpr member functions without const</td><td>Bristol</td><td>Complete</td><td>3.4</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/papers/2013/n3662.html">3662</a></td><td>LWG</td><td>C++ Dynamic Arrays (dynarray)</td><td>Bristol</td><td><I>Removed from Draft Standard</I></td><td>n/a</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/papers/2013/n3659.html">3659</a></td><td>SG1</td><td>Shared Locking in C++</td><td>Bristol</td><td>Complete</td><td>3.4</td></tr>
<tr><td></td><td></td><td></td><td></td><td></td><td></td></tr>
<tr><td><a href="http://wiki.edg.com/twiki/pub/Wg21chicago2013/FormalMotions/N3779-complex_literals.pdf">3779</a></td><td>LWG</td><td>User-defined Literals for std::complex</td><td>Chicago</td><td>Complete</td><td>3.4</td></tr>
<tr><td><a href="http://wiki.edg.com/twiki/pub/Wg21chicago2013/FormalMotions/N3789.txt">3789</a></td><td>LWG</td><td>Constexpr Library Additions: functional</td><td>Chicago</td><td>Complete</td><td>3.4</td></tr>
<tr><td><a href="http://wiki.edg.com/twiki/pub/Wg21chicago2013/FormalMotions/n3778.html">3778</a></td><td>CWG</td><td>Sized deallocation</td><td>Chicago</td><td></td><td></td></tr>
<!-- <tr><td></td><td></td><td></td><td></td><td></td><td></td></tr> -->
</table>
<h3>Library Working group Issues Status</h3>
<!-- <I>Note: "NAD" means that the issue was deemed "Not a defect"</I> -->
<table id="issues" border="1">
<tr><th>Issue #</th><th>Issue Name</th><th>Meeting</th><th>Status</th></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#1214">1214</a></td><td>Insufficient/inconsistent key immutability requirements for associative containers</td><td>Kona</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2009">2009</a></td><td>Reporting out-of-bound values on numeric string conversions</td><td>Kona</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2010">2010</a></td><td>is_* traits for binding operations can't be meaningfully specialized</td><td>Kona</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2015">2015</a></td><td>Incorrect pre-conditions for some type traits</td><td>Kona</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2021">2021</a></td><td>Further incorrect usages of result_of</td><td>Kona</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2028">2028</a></td><td>messages_base::catalog overspecified</td><td>Kona</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2033">2033</a></td><td>Preconditions of reserve, shrink_to_fit, and resize functions</td><td>Kona</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2039">2039</a></td><td>Issues with std::reverse and std::copy_if</td><td>Kona</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2044">2044</a></td><td>No definition of "Stable" for copy algorithms</td><td>Kona</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2045">2045</a></td><td>forward_list::merge and forward_list::splice_after with unequal allocators</td><td>Kona</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2047">2047</a></td><td>Incorrect "mixed" move-assignment semantics of unique_ptr</td><td>Kona</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2050">2050</a></td><td>Unordered associative containers do not use allocator_traits to define member types</td><td>Kona</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2053">2053</a></td><td>Errors in regex bitmask types</td><td>Kona</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2061">2061</a></td><td>make_move_iterator and arrays</td><td>Kona</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2064">2064</a></td><td>More noexcept issues in basic_string</td><td>Kona</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2065">2065</a></td><td>Minimal allocator interface</td><td>Kona</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2067">2067</a></td><td>packaged_task should have deleted copy c'tor with const parameter</td><td>Kona</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2069">2069</a></td><td>Inconsistent exception spec for basic_string move constructor</td><td>Kona</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2096">2096</a></td><td>Incorrect constraints of future::get in regard to MoveAssignable</td><td>Kona</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2102">2102</a></td><td>Why is std::launch an implementation-defined type?</td><td>Kona</td><td>Complete</td></tr>
<tr><td></td><td></td><td></td><td></td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2071">2071</a></td><td>std::valarray move-assignment</td><td>Portland</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2074">2074</a></td><td>Off by one error in std::reverse_copy</td><td>Portland</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2081">2081</a></td><td>Allocator requirements should include CopyConstructible 2083 const-qualification on weak_ptr::owner_before</td><td>Portland</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2083">2083</a></td><td>const-qualification on weak_ptr::owner_before</td><td>Portland</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2086">2086</a></td><td>Overly generic type support for math functions</td><td>Portland</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2099">2099</a></td><td>Unnecessary constraints of va_start() usage</td><td>Portland</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2103">2103</a></td><td>std::allocator_traits<std::allocator<T>>::propagate_on_container_move_assignment</td><td>Portland</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2105">2105</a></td><td>Inconsistent requirements on const_iterator's value_type</td><td>Portland</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2110">2110</a></td><td>remove can't swap but note says it might</td><td>Portland</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2123">2123</a></td><td>merge() allocator requirements for lists versus forward lists</td><td>Portland</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2005">2005</a></td><td>unordered_map::insert(T&&) protection should apply to map too</td><td>Portland</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2011">2011</a></td><td>Unexpected output required of strings</td><td>Portland</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2048">2048</a></td><td>Unnecessary mem_fn overloads</td><td>Portland</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2049">2049</a></td><td>is_destructible is underspecified</td><td>Portland</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2056">2056</a></td><td>future_errc enums start with value 0 (invalid value for broken_promise)</td><td>Portland</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2058">2058</a></td><td>valarray and begin/end</td><td>Portland</td><td>Complete</td></tr>
<tr><td></td><td></td><td></td><td></td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2091">2091</a></td><td>Misplaced effect in m.try_lock_for()</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2092">2092</a></td><td>Vague Wording for condition_variable_any</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2093">2093</a></td><td>Throws clause of condition_variable::wait with predicate</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2094">2094</a></td><td>duration conversion overflow shouldn't participate in overload resolution</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2122">2122</a></td><td>merge() stability for lists versus forward lists</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2128">2128</a></td><td>Absence of global functions cbegin/cend</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2145">2145</a></td><td>error_category default constructor</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2147">2147</a></td><td>Unclear hint type in Allocator's allocate function</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2148">2148</a></td><td>Hashing enums should be supported directly by std::hash</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2149">2149</a></td><td>Concerns about 20.8/5</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2162">2162</a></td><td>allocator_traits::max_size missing noexcept</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2163">2163</a></td><td>nth_element requires inconsistent post-conditions</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2169">2169</a></td><td>Missing reset() requirements in unique_ptr specialization</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2172">2172</a></td><td>Does atomic_compare_exchange_* accept v == nullptr arguments?</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2080">2080</a></td><td>Specify when once_flag becomes invalid</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2098">2098</a></td><td>promise throws clauses</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2109">2109</a></td><td>Incorrect requirements for hash specializations</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2130">2130</a></td><td>missing ordering constraints for fences</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2138">2138</a></td><td>atomic_flag::clear ordering constraints</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2140">2140</a></td><td>notify_all_at_thread_exit synchronization</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2144">2144</a></td><td>Missing noexcept specification in type_index</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2174">2174</a></td><td>wstring_convert::converted() should be noexcept</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2175">2175</a></td><td>string_convert and wbuffer_convert validity</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2176">2176</a></td><td>Special members for wstring_convert and wbuffer_convert</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2177">2177</a></td><td>Requirements on Copy/MoveInsertable</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2185">2185</a></td><td>Missing throws clause for future/shared_future::wait_for/wait_until</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2187">2187</a></td><td>vector<bool> is missing emplace and emplace_back member functions</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2190">2190</a></td><td>ordering of condition variable operations, reflects Posix discussion</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2196">2196</a></td><td>Specification of is_*[copy/move]_[constructible/assignable] unclear for non-referencable types</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2197">2197</a></td><td>Specification of is_[un]signed unclear for non-arithmetic types</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2200">2200</a></td><td>Data race avoidance for all containers, not only for sequences</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2203">2203</a></td><td>scoped_allocator_adaptor uses wrong argument types for piecewise construction</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2207">2207</a></td><td>basic_string::at should not have a Requires clause</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2209">2209</a></td><td>assign() overspecified for sequence containers</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2210">2210</a></td><td>Missing allocator-extended constructor for allocator-aware containers</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2211">2211</a></td><td>Replace ambiguous use of "Allocator" in container requirements</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2222">2222</a></td><td>Inconsistency in description of forward_list::splice_after single-element overload</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2225">2225</a></td><td>Unrealistic header inclusion checks required</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2229">2229</a></td><td>Standard code conversion facets underspecified</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2231">2231</a></td><td>DR 704 removes complexity guarantee for clear()</td><td>Bristol</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2235">2235</a></td><td>Undefined behavior without proper requirements on basic_string constructors</td><td>Bristol</td><td>Complete</td></tr>
<tr><td></td><td></td><td></td><td></td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2141">2141</a></td><td>common_type trait produces reference types</td><td>Chicago</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2235">2235</a></td><td>Undefined behavior without proper requirements on basic_string constructors</td><td>Chicago</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2246">2246</a></td><td>unique_ptr assignment effects w.r.t. deleter</td><td>Chicago</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2247">2247</a></td><td>Type traits and std::nullptr_t</td><td>Chicago</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2085">2085</a></td><td>Wrong description of effect 1 of basic_istream::ignore</td><td>Chicago</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2087">2087</a></td><td>iostream_category() and noexcept</td><td>Chicago</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2143">2143</a></td><td>ios_base::xalloc should be thread-safe</td><td>Chicago</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2150">2150</a></td><td>Unclear specification of find_end</td><td>Chicago</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2180">2180</a></td><td>Exceptions from std::seed_seq operations</td><td>Chicago</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2194">2194</a></td><td>Impossible container requirements for adaptor types</td><td>Chicago</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2013">2013</a></td><td>Do library implementers have the freedom to add constexpr?</td><td>Chicago</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2018">2018</a></td><td>regex_traits::isctype Returns clause is wrong</td><td>Chicago</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2078">2078</a></td><td>Throw specification of async() incomplete</td><td>Chicago</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2097">2097</a></td><td>packaged_task constructors should be constrained</td><td>Chicago</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2100">2100</a></td><td>Timed waiting functions cannot timeout if launch::async policy used</td><td>Chicago</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2120">2120</a></td><td>What should async do if neither 'async' nor 'deferred' is set in policy?</td><td>Chicago</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2159">2159</a></td><td>atomic_flag initialization</td><td>Chicago</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2275">2275</a></td><td>Why is forward_as_tuple not constexpr?</td><td>Chicago</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2284">2284</a></td><td>Inconsistency in allocator_traits::max_size</td><td>Chicago</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2298">2298</a></td><td>is_nothrow_constructible is always false because of create<></td><td>Chicago</td><td>Complete</td></tr>
<tr><td><a href="http://www.open-std.org/jtc1/sc22/wg21/docs/lwg-defects.html#2300">2300</a></td><td>Redundant sections for map and multimap members should be removed</td><td>Chicago</td><td>Complete</td></tr>
<tr><td>National Body comment 'GB 9'</td> <td>Remove gets from C++14</td><td>Chicago</td><td>Complete</td></tr>
<!-- <tr><td></td><td></td><td></td><td></td><td></td><td></td></tr> -->
</table>
<p>Last Updated: 22-Oct-2013</p>
</div>
</body>
</html>
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"pile_set_name": "Github"
}
| 0 |
Q:
Passing multiple values to a parameter for a Fiddler POST request
I am trying to pass multiple values for a parameter in a POST request body as follows
var1=1&var2=2&var34=3,4&var5=5
I've tried several ways to pass var34 as a string of values 3 and 4 but still not working. Need some help.
Thanks!!!
A:
This isn't really a question about Fiddler, so it's not clear what you're asking specifically.
The server interprets POST data according to its own rules, and there's no standard for handling duplicate name/values in urlencoded data.
Some servers would accept var1=1&var2=2&var34=3,4&var5=5 as you've used, while some would prefer var1=1&var2=2&var34=3&var34=4&var5=5.
What error or problem are you encountering?
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"pile_set_name": "StackExchange"
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| 0 |
Cuckold Eats the Cum from Her Pussy
|
{
"pile_set_name": "OpenWebText2"
}
| 0.057143 |
The centrosome is of fundamental importance to animal cells in that it is the principal nucleator of the microtubule (MT) cytoskeleton and harbors the centrioles, specialized structures that are required for cilia formation and contribute to spindle-pole positioning. Through these principal roles, the centrosome is important in embryonic development and human disease. During interphase, MTs are required for vesicle trafficking and cell polarity. In most cell types, many of the MTs that form the mitotic spindle originate at the centrosome. The centrosome also has important roles beyond MT nucleation, including functions in cytokinesis, progression through the cell cycle, and in sequestering or positioning some proteins to control when and where they are active. The primary aims of this proposal are to determine the molecular mechanism of MT nucleation, and to understand how the nucleating machinery is assembled and regulated. Moreover we will begin to explore the mechanism by which microtubule doublets and triplets are formed at the centriole by focusing on the newly discovered ?- and ?-tubulins and their as yet unknown, binding partners. Our laboratory is uniquely poised to utilize a hierarchical array of structural approaches (x-ray crystallography, electron microscopic (EM) single particle reconstruction, and EM Tomography, small-angle x-ray scattering (SAXS)) to determine the structures of ?-, ?- and ?-tubulin complexes in vitro and in situ, and to understand their mechanism of action through functional studies and innovative kinetic modeling. By combining structural studies, MT assembly experiments and kinetic modeling, our previous work is leading to a paradigm shift in understanding the underlying principles of MT formation, suggesting a new role for GTP, a different model for MT assembly and an unexpected mode of regulation of nucleation in the ?-tubulin complexes. The proposed experiments will continue and expand upon these results, providing a detailed understanding of the physical origins of MT assembly, and the cellular machinery that dictates MT formation. In vitro predictions of modes of action or regulation will be assayed in vivo using mutagenesis and siRNA and live imaging. Spanning size scales from the atomic to the entire organelle, our long-term goal is to synthesize an atomic resolution picture of all the relevant structural and functional interactions between 12-tubulin, ?-, ?- and ?-tubulin complexes, regulatory proteins and the centrosomal matrix. Public Health Relevance: The normal function of centrosomes and centrioles is directly relevant to human disease, and the proposed work is aimed at understanding the molecular mechanisms of these cellular components. Abnormal centrosome number and behavior is a common hallmark of cancer cells, and centriole defects are involved in many human ciliary diseases, including nephronophthisis, Bardet-Biedl syndrome, Meckel syndrome, and Oral-Facial-Digital syndrome.
|
{
"pile_set_name": "NIH ExPorter"
}
| 0 |
King’s Lynn Speedway welcomes press and photographers from local and national media. Below is a guide to how you can attend one of our home fixtures during the season.
If you would like to be added to our press release list, please contact our Press Office at pressoffice@kingslynn-speedway.com for more information. Any requests for interviews with either management or riders should also be directed to the King's Lynn Speedway Press Office.
Media passes can be collected from the race office which is located near the riders and officials’ entrance at the Adrian Flux Arena.
Press Room
The Press Box at the Adrian Flux Arena is situated on the start/finish straight. There are plenty of power points available for media use and every seat has its own desk. The Press Box should be vacated by 11pm on race days.
Photographers
Any photographer taking pictures at the Adrian Flux Arena is required to wear a high-visibility vest at all times. Photographers will not be permitted inside the track without a bib.
Photographers must not take photos in-between the catch fence and track safety fence. This is for your safety. Failure to comply may result in your media pass being revoked.
|
{
"pile_set_name": "Pile-CC"
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| 0 |
BRUTAL PEGGING by amateur girl - she fucks better than ANY man! Femdom strapon sex with huge cumshot
|
{
"pile_set_name": "OpenWebText2"
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| 0.05 |
var convert = require('./convert'),
func = convert('assignAllWith', require('../assignWith'));
func.placeholder = require('./placeholder');
module.exports = func;
|
{
"pile_set_name": "Github"
}
| 0 |
The Xoom tablet has a respectably fast Verizon 3G connection, but Motorola promises a free upgrade to Verizon's faster 4G network within a few months.
To do that, however, you'll need to ship your Xoom back to the manufacturer for more than a week.
It's not often I laugh out loud when researching a post, but when reading up on the Motorola Xoom 3G to 4G upgrade procedure, I sounded like barking dog. If anyone has ever designed a more convoluted, ridiculous way to rush an unfinished product to market, I have yet to see it. But more on that in a moment.
Of course, you can buy Motorola's Android 3.0–powered, 3G-enabled Xoom today. The promised upgrade to 4G is now slated for May (officially "90 days after launch"), and the upgrade involves shipping the tablet back to Motorola (also free) and waiting up to six business days (translation: more than a week). This despite the fact that the Xoom is clearly designed for easy upgrades, and the upgrade procedure probably takes no more than 10 minutes.
For customers who are happy to be without their tablets for a while, this is clearly good news: You get a free bump to use faster 4G networks. It's good for Verizon, too, as you might sign up for a 4G plan (although you don't have to). But for Motorola it's plain dumb.
I don't know how much it costs to pay for two-way shipping, opening up a tablet and replacing a part, but I can bet it isn't cheap. After all, there's a reason that replacing gadgets is often cheaper than repairing them. Add to this the fact that Motorola will have cut profit margins to the bone to compete with the iPad, and I can see this stunt losing the company a lot of money.
So why do it? Why not wait until it is ready and launch it in the summer? Two words: iPad 2. The iPad 2 will be here in April, and maybe even as early as next week, at which time many of the Xoom's "advantages" will disappear. If our guesses are right, the Xoom's camera and fast processor will no longer be unique, and the only extra will be 4G, aka "the ability to connect to a fast but sparsely deployed data network." It seems rather obvious that Motorola was absolutely desperate to get its tablet out the door before Apple makes it irrelevant.
So, want to hear about what had me chuckling? Take a look at the "Getting Ready Guide" for the upgrade. Sandwiched in the middle is rather huge section on backing up your data before sending it off to Motorola. It boils down to this: Connect your Xoom via USB, dig down through its file system and then copy (via drag and drop) the files and folders onto your computer.
Then, when your machine is finally returned after surgery, you put it all back again. Just the kind of thing Auntie May will find it dead-easy to do.
And that's before we even get to encrypting the contents to keep it safe in transit ("If you interrupt the encryption process, you will lose some or all of your data").
Remind me why nobody is buying Android tablets, again?
Motorola Xoom Upgrade program [Verizon via Droid Life]
See Also:
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{
"pile_set_name": "OpenWebText2"
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| 0 |
The Sensational Spider-Man
The Sensational Spider-Man is a comic book series starring Spider-Man published by Marvel Comics for 35 issues (#0–33, with # -1 published in July 1997 between #17 and #18), from January 1996 until November 1998.
Publication history
The Sensational Spider-Man title was first used for various reprints, including Marvel Treasury Edition #14 (1977), 22 (1979) and 27 (1980) which featured various reprints from Marvel Team-Up and The Amazing Spider-Man, a trade paperback in 1988 featuring Frank Miller's Spider-Man work, and a prestige format one-shot special called The Sensational Spider-Man: Nothing Can Stop the Juggernaut () in 1989 which reprinted The Amazing Spider-Man issues #229 and #230.
The ongoing The Sensational Spider-Man series was initially conceived to be the flagship showcase for the new Ben Reilly Spider-Man. It replaced the Web of Spider-Man series.
The initial seven issues (#0–6, January–July 1996) were written and pencilled by Dan Jurgens, who had helped revive interest in Superman for DC Comics in the mid-1990s. Jurgens pushed strongly for the restoration of Peter Parker as the true Spider-Man and plans were made to enact this soon, but Bob Harras, the new Editor-in-chief, demanded the story be deferred until after the Onslaught crossover. Jurgens had by this stage become disillusioned with the immense amount of group planning and constant changes of ideas and directions and took this as the last straw, resigning from the title.
He was succeeded by writer Todd DeZago and penciller Mike Wieringo, who remained as the title's regular creative team for the remainder of its run. It lasted for 35 issues (33 regularly numbered issues as well as an initial issue "0" and the "-1" Flashback issue, released mid-run).
In February 2006, with issue #23, the series Marvel Knights Spider-Man was moved from the Marvel Knights imprint and renamed The Sensational Spider-Man volume 2.
Collections
Spider-Man: The Complete Ben Reilly Epic Book 1 (#0)
Spider-Man: The Complete Ben Reilly Epic Book 2 (#1)
Spider-Man: The Complete Ben Reilly Epic Book 3 (#2–3)
Spider-Man: Ben Reilly Omnibus (#0-3)
Spider-Man: The Complete Ben Reilly Epic Book 4 (#4–6)
Spider-Man: The Complete Ben Reilly Epic Book 5 (#7–10)
Spider-Man: The Complete Ben Reilly Epic Book 6 (Sensational Spider-Man #11)
X-Men: The Complete Onslaught Epic Vol. 2 (#8)
Spider-Man: Revelations (#11)
Issues #13–15 of The Sensational Spider-Man (vol. 1) were reprinted in the Spider-Man: Savage Land prestige format trade paperback () in June 1997 (with the book titled as Spider-Man: The Savage Land Saga! on the cover only).
Spider-Man by Todd DeZago & Mike Wieringo Vol. 1 (#7-24, -1) (2017) (, 456 pages)
Spider-Man: Spider-Hunt (#25–26)
Spider-Man: Identity Crisis (#27–28)
Spider-Man: The Gathering of Five (#32–33)
Sources
The Grand Comics Database
The Unofficial Handbook of Marvel Comics Creators
Category:Spider-Man titles
Category:Comics by Dan Jurgens
|
{
"pile_set_name": "Wikipedia (en)"
}
| 0 |
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{
"pile_set_name": "OpenWebText2"
}
| 0.051282 |
When Vendilion Clique enters the battlefield, look at target player's hand. You may choose a nonland card from it. If you do, that player reveals the chosen card, puts it on the bottom of his or her library, then draws a card.
Magic: the Gathering is trademark and copyright Wizards of the Coast, Inc., a subsidiary of Hasbro, Inc. All rights reserved. MTGAssist.com is not affiliated with these entities. Articles and comments are user-submitted and do not represent official endorsements of this site.
MTGAssist.com is not affiliated with the mobile app "MTG Assist" or Kiiwi Up.
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{
"pile_set_name": "Pile-CC"
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{
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{
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{
"pile_set_name": "Pile-CC"
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{
"pile_set_name": "Pile-CC"
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| 0.057239 |
Fox Sports Australia – The former Test spinner believes junior cricketers are too focused on winning games of cricket and have grown accustomed to taking too many risks with the bat.
Summary
The former Test spinner believes junior cricketers are too focused on winning games of cricket and have grown accustomed to taking too many risks with the bat.
Robertson added that the approach of T20 cricket has crept into the Test game, leading to an Australian side that is “playing with risk and hope” against Pakistan in the UAE.
“I think when we’ve taken the importance out of grade cricket …
AUSTRALIA SLUMPS TO NEW LOW WITH HORRIFIC COLLAPSE‘NERVES’ AND ‘NAIVETY’: HOW AUSTRALIA CRUMBLED IN DUBAI DIRTRobertson said the next generation of cricketers should work with mentors who played during an era without T20 cricket.
“I need [to see] hardened cricket to make hardened cricketers, as we watch a Test match with a team that are playing with risk and hope.”
|
{
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| 0 |
An unfortunate case of Pendred syndrome.
To report a patient with Pendred syndrome who developed life-threatening hypokalaemia as an unpredicted consequence of implant-induced imbalance and alcohol dependency, leading to multiple cardiac arrests. Addenbrooke's Hospital, Cambridge, UK. Case report and review of the English language literature concerning Pendred syndrome and cochlear implantation in Pendred syndrome patients. Pendred syndrome is an autosomal recessive disorder which mainly affects the inner ear, thyroid and kidneys. It accounts for 10 per cent of syndromic hearing loss cases. The majority of Pendred syndrome patients are referred to cochlear implant programmes for hearing assessment and therapy. They may also have an underlying metabolic abnormality which is not clinically apparent. Providing cochlear implants to patients with Pendred syndrome demands extensive knowledge of this condition, in order to avoid potential morbidity.
|
{
"pile_set_name": "PubMed Abstracts"
}
| 0 |
Q:
Python Package and module version management
I plan to develop a medium scale web application (with lot of back-end work) using multiple packages (internal and external), since it's my first experience with such scale, can I get some advice on:
How to ensure that all dependencies are satisfied (no required package/module is missing, packages were imported from right location etc.)
How to manage versions of packages/modules. I want to be able to introduce new versions of packages/modules with minimal code changes in other connected packages/modules.
Please let me know if there is a tool that can be of help in this.
If there is any other challenge (which I may not even be aware of) that comes in managing code with this scale then please caution me and provide ways to resolve it.
What I know currently (and think that it may help in code management):
__all__ to define exportable modules.
Use of preceding single underscore to prevent modules from getting imported
__init__.py to manage imports at package level (so when I do import package_name then __init__.py can centrally control other imports)
PEP 328 to manage relative imports, importlib and other such stuff around importing.
I suppose some of the 3rd party packages also define __version__ or VERSION variable to check the version at runtime, but I am not sure if I can rely on it.
If there are books, blogs etc. that can help then please let me know.
EDIT: I am not sure if this type of question fits here on SO. If not then I apologize.
A:
How to ensure that all dependencies are satisfied (no required package/module is missing, packages were imported from right location etc.)
Use a virtualenv and freeze the packages with pip to a requirements file:
$ pip freeze > requirements.txt
$ cat requirements.txt
argparse==1.2.1
distribute==0.6.31
wsgiref==0.1.2
Basically, use virtualenv, distribute and pip whenever you have some code that'll need a module installed.
To install packages according to the version specified in your requirements.txt:
pip install -r requirements.txt
|
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| 0 |
What If We Said Chores And Allowance Should Have No Bearing On One Another?
Because chores and allowance provide entirely different learning opportunities...
You know who else needs a budget and needs to learn how to manage their money? Your kids.
Being deeply invested in budgeting with more kids than most, I’ve given this subject a lot of thought.
Allowance has always been a huge hassle for us. It’s hard to be consistent, it creates a lot of undue overhead, which makes it even harder to be consistent.
After interviewing Ron, Lieber, the author of The Opposite of Spoiled, last year, we changed things up. Ron has studied and researched for years focused on how to raise kids who are grateful, kind, generous, and just generally not spoiled. I asked him about his #1 biggest takeaway, and what he said surprised me: separate chores from allowance.
Huh. I had to think about that a little bit, but it began to make a lot of sense to me, and we’ve since implemented with great success.
Chores And Allowance Serve Different Purposes
We give our kids chores so they can learn to work and contribute. They are part of a family and it is important for each of them to do their part, and appreciate the contributions of one another.
We give them money—an allowance, totally independent of chores—so they can learn how to manage money.
We used to attach commissions to different jobs. When we ran into some quality control issues, then we were paying based on how well your chores were done, how few times we had to ask you to do them, or whether or not Mom was in a good mood when payment came due. It was impossible to be consistent. Not to mention it felt like anytime we asked them to do something they were expecting to get paid. The balance was all off.
Now, we pay our kids an allowance every week. It is the same amount, every single time. It has nothing to do with chores or behavior. You just get it.
Part of me still reacts a little bit like, “No! That’s not right! You don’t just get money. What are we teaching these kids if you just get money automatically for breathing?” But we are very disciplined when it comes to chores.
Work Isn’t Just About Money
We’re teaching them to work. Everyone does their chores, everyone is contributing to the family. This isn’t something you get paid for. You don’t get an extra gold star. It is just what is expected. It’s just a part of being in our family.
Money Management Must Be Taught
And we’re teaching them to manage their money. The whole point of the allowance is to let them experience holding money, handling money, losing money, saving money—managing money. It takes practice. You must battle with your own emotions, weigh your own priorities, experience the consequences. The allowance provides valuable practice.
For us right now, with kids ranging from 13 to one, we’ve drawn a hard line between chores and allowance and it’s working very well. What is working for you and your family?
If you can’t wait until next week for more whiteboard wisdom, subscribe to our YouTube channel. If you have a question or an idea you’d like us to address in a future Whiteboard Wednesday episode—we’d love to hear from you: [email protected]
Your Next Step
Remember, budgeting is not restrictive. You won’t be spending less, you’ll be spending right. You can do this! Today. Right now. What do you have to lose? Except all that debt and stress. (Ok, so kind of a lot.)
|
{
"pile_set_name": "Pile-CC"
}
| 0 |
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{
"pile_set_name": "NIH ExPorter"
}
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{
"pile_set_name": "Enron Emails"
}
| 0.1 |
#-- encoding: UTF-8
#-- copyright
# OpenProject is an open source project management software.
# Copyright (C) 2012-2020 the OpenProject GmbH
#
# This program is free software; you can redistribute it and/or
# modify it under the terms of the GNU General Public License version 3.
#
# OpenProject is a fork of ChiliProject, which is a fork of Redmine. The copyright follows:
# Copyright (C) 2006-2017 Jean-Philippe Lang
# Copyright (C) 2010-2013 the ChiliProject Team
#
# This program is free software; you can redistribute it and/or
# modify it under the terms of the GNU General Public License
# as published by the Free Software Foundation; either version 2
# of the License, or (at your option) any later version.
#
# This program is distributed in the hope that it will be useful,
# but WITHOUT ANY WARRANTY; without even the implied warranty of
# MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the
# GNU General Public License for more details.
#
# You should have received a copy of the GNU General Public License
# along with this program; if not, write to the Free Software
# Foundation, Inc., 51 Franklin Street, Fifth Floor, Boston, MA 02110-1301, USA.
#
# See docs/COPYRIGHT.rdoc for more details.
#++
require 'roar/decorator'
require 'roar/hypermedia'
require 'roar/json/hal'
require 'api/v3/utilities/path_helper'
module API
module Decorators
class Single < ::Roar::Decorator
include ::Roar::JSON::HAL
include ::Roar::Hypermedia
include ::API::V3::Utilities::PathHelper
attr_reader :current_user, :embed_links
class_attribute :as_strategy
self.as_strategy = ::API::Utilities::CamelCasingStrategy.new
# Use this to create our own representers, giving them a chance to override the instantiation
# if desired.
def self.create(model, current_user:, embed_links: false)
new(model, current_user: current_user, embed_links: embed_links)
end
def initialize(model, current_user:, embed_links: false)
raise 'no represented object passed' if model_required? && model.nil?
@current_user = current_user
@embed_links = embed_links
super(model)
end
property :_type,
exec_context: :decorator,
render_nil: false,
writeable: false
def self.self_link(path: nil, id_attribute: :id, title_getter: ->(*) { represented.name })
link :self do
self_path = self_v3_path(path, id_attribute)
link_object = { href: self_path }
title = instance_eval(&title_getter)
link_object[:title] = title if title
link_object
end
end
class_attribute :to_eager_load
class_attribute :checked_permissions
def current_user_allowed_to(permission, context: represented.respond_to?(:project) ? represented.project : nil)
current_user.allowed_to?(permission, context)
end
# Override in subclasses to specify the JSON indicated "_type" of this representer
def _type; end
def call_or_send_to_represented(callable_or_name)
if callable_or_name.respond_to? :call
instance_exec(&callable_or_name)
else
represented.send(callable_or_name)
end
end
def call_or_use(callable_or_value)
if callable_or_value.respond_to? :call
instance_exec(&callable_or_value)
else
callable_or_value
end
end
def datetime_formatter
::API::V3::Utilities::DateTimeFormatter
end
# If a subclass does not depend on a model being passed to this class, it can override
# this method and return false. Otherwise it will be enforced that the model of each
# representer is non-nil.
def model_required?
true
end
def self_v3_path(path, id_attribute)
path ||= _type.underscore
id = if id_attribute.respond_to?(:call)
instance_eval(&id_attribute)
else
represented.send(id_attribute)
end
id = [nil] if id.nil?
api_v3_paths.send(path, *Array(id))
end
end
end
end
|
{
"pile_set_name": "Github"
}
| 0 |
Our Blog
Posted by
Collaborative Counseling
There is a common misconception that depression is a choice. The truth is that depression is a common yet serious mood disorder that has to do with a chemical imbalance in the brain. People experience depression in a number of ways and symptoms can range from mild to severe. Depression can affect how someone feels and thinks as well their daily activities such as work and sleeping. There are a variety of factors that can put someone at-risk for developing depression such as:
Genetics: Depression can be hereditary and runs in families.
Environmental Factors: exposure to neglect, abuse and violence can be risk factors for depression.
Personality: Traits such as low self-esteem and being easily overwhelmed by stress can make people more vulnerable to depression.
Gender: Women are more likely than men to develop depression.
It should be noted that depression can look different for everyone. Some common symptoms of depression include.
Difficulty sleeping or sleeping too much
Loss of interest in hobbies/activities
Appetite or weight changes
Feeling hopeless
Trouble concentrating
Irritability
Treatments for Depression
There are several therapeutic treatment options for depression. Therapies such as cognitive behavioral therapy (CBT), mindfulness-based CBT and dialectical behavioral therapy (DBT) have all been shown to help reduce depressive symptoms and increasing coping skills.
Many courses of treatment for depression will include medications such as anti-depressants in combination with psychotherapy to treat depression. Remember, no two people are alike and therefore, neither are their treatments. What worked for one person may not work for you.
Additionally, activities such as yoga and exercise in general as well as meditation and healthy eating can all have an impact on our overall mood and help to decrease depressive symptoms.
If you are struggling with depression the first step is reaching out for help. Visit our website at: https://www.collaborativemn.com/ to learn more about the services we offer and the people who can help.
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{
"pile_set_name": "Pile-CC"
}
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{
"pile_set_name": "OpenWebText2"
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{
"pile_set_name": "OpenWebText2"
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{
"pile_set_name": "Pile-CC"
}
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California Nights (Best Coast album)
California Nights is the third studio album by American rock duo Best Coast. It was released on May 1, 2015, by Harvest Records. It was produced by Wally Gagel, who also produced the duo's 2013 EP Fade Away.
The band announced the album along with tour dates and the release of a "dreamlike" video directed by Adam Harding for the title track, which also served as the lead single. On the band's official website, singer-songwriter Bethany Cosentino described the band's approach to the making of the album, stating: "In LA, there's a real darkness that you don't see unless you know where to look. That's a theme we very consciously decided to explore and play with when making this record. We related to the idea that things may look or sound fun and upbeat, but they may not actually always be that way."
A video for second single "Heaven Sent" directed by Lana Kim and Cosentino was released on April 1, 2015. Third single "Feeling Ok" followed in mid-April, which the duo performed on Conan on May 5. "In My Eyes" was serviced to US alternative radio on February 23, 2016, as the album's fourth single.
Two outtakes from the album sessions, "Late 20s" and "Bigger Man", were released on an exclusive Record Store Day release in April 2016.
Critical reception
California Nights has received generally positive reviews from music critics. At Metacritic, which assigns a weighted mean rating out of 100 to reviews from mainstream critics, the album has received an average score of 69 based on 26 reviews, which indicates "generally favorable reviews".
Track listing
Personnel
Credits adapted from the liner notes of California Nights.
Best Coast
Bethany Cosentino – guitar, vocals
Bobb Bruno – guitar, bass, keyboards
Technical
Wally Gagel – production, recording, mixing
Seth Olansky – assistance
Vincent Silva – assistance
Howie Weinberg – mastering
Gentry Studer – mastering assistance
Additional musicians
Brady Miller – drums, guitar, percussion, keyboards
Wally Gagel – percussion, bass synthesizer, keyboards, guitar
Artwork
Janell Shirtcliff – photography
Lawrence Azerrad – design
Charts
Release history
References
Category:2015 albums
Category:Best Coast albums
Category:Harvest Records albums
|
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"pile_set_name": "Wikipedia (en)"
}
| 0 |
GPSMAP® 585
The GPSMAP 585 is a full-function chart plotter that features an ultra-bright 5” WQVGA color display along with an improved feature of high-speed map drawing and panning. It’s ready to go with an easy-to-use interface and a built-in worldwide basemap. The 585 is unique Garmin chart plotters that not only equip with English language but also with Asian languages including Simplified Chinese and Bahasa Indonesia. GPSMAP 585 is designed specifically for professional fishermen and comes with the advantages of Garmin’s renowned GPS168/178C chart plotters. What’s more, you can now fish with a high quality chart plotter at more affordable cost.
Explore the Seas
The GPSMAP 585 comes standard with a built-in high-sensitivity GPS module for superior satellite tracking and quicker acquisition times. And with a SD card slot, it’s easy to add additional maps without connecting to a computer.
Add Sonar
Where applicable, the sounder version, GPSMAP 585, comes with optional transducer that can clearly illustrate depth contours, fish targets and structures. Whether you’re fishing in freshwater or off the coast, you can always find right Garmin transducers of various kinds to suit your needs. The GPSMAP 585 is also NMEA 0183 compliant for connectivity with sensors, instruments and future marine offerings.
Physical & Performance:
Unit dimensions, WxHxD:
5.9" x 6.4" x 2.9" (15.0 x 16.3 x 7.4 cm)
Display size, WxH:
5”, 120.7x75.8mm
Display resolution, WxH:
480x272 pixels
Display type:
WQVGA
Weight:
390g
Waterproof:
(IPX7)
Maps & Memory:
Basemap:
Preloaded maps:
Ability to add maps:
Accepts data cards:
SD card slot
Waypoints/favorites/locations:
6000
Routes:
150 tracks/250 points
Features:
CANet® compatible:
Supports AIS (tracks target ships' position):
Supports DSC (displays position data from DSC capable VHF radio):
Audible alarms:
Tide tables:
Sun and moon information:
3-D map view:
Dual-frequency sonar capable:
Dual-beam sonar capable :
Split-screen zoom:
Split-screen sonar/gps:
Ultrascroll™ (displays fish targets at higher boat speeds):
See-thru® technology (exposes fish hidden in cover):
Fish Symbol ID (helps identify fish targets):
AutoGain Technology (minimizes clutter, maximizes targets):
Whiteline (indicates hard or soft bottom):
Adjustable depth line (measures depth of underwater objects):
A-scope (real time display of fish passing through transducer beam):
Bottom lock (shows return from the bottom up):
Water temperature log and graph:
Water temperature sensor included:
(need to equipt with correct tranducer)
Sonar:
Frequency:
50/200 kHz
Transmit power:
500W(RMS), 4,000W(peak to peak)
Voltage range:
10-36 VDC
Maximum depth*:
1,500ft
Cone angle:
20 degrees
*Depth capacity is dependent on water salinity, bottom type, and other water conditions.
|
{
"pile_set_name": "Pile-CC"
}
| 0 |
Data is the new oil.
Without it, your sales engine stops running.
Like oil, data needs to be refined.
Or else, it won’t fuel your sales machine.
The problem is that B2B data has a very short shelf life.
24% to 36% of your CRM data decays each year Tweet this!
Tweet this! 25% of sales contacts are invalid at any given time
Poor data causes reps to waste 27.3% of their time,
and ends up costing you 12% of revenues.
The good news is that,
by following a few simple data hygiene best practices,
richer data-driven sales conversations are always within your reach…
Learn how to Utilize a Data-Driven Approach to Generate Technology Leads!
#1 Find out what’s wrong
Start with a thorough audit of your CRM
Interview key data handlers and users
Identify what types of errors and potential issues you encounter
Related: Not Just an Address Book: 4 Hacks to Turn a CRM into a True Sales Tool
#2 Fix what’s broken
Validate data entry errors and typos first
Research and update inaccuracies like phone numbers, email addresses, etc.
Define rules for merging and removing duplicate records
Related: Symptoms of an Unhealthy Email Marketing List (and How to Clean It)
#3 Fill missing values
Use the main company phone number as a placeholder until you obtain a direct line
Infer email addresses from common company-specific email patterns
Populate empty fields with data from publicly-available sources and third-party providers
#4 Fit data together
Follow standard naming conventions for contacts and businesses
Make sure to use consistent abbreviations and punctuations throughout a column
Create formatting rules for categorical fields (e.g., job titles, industries, etc.)
#5 Feed into a data management process
Plan for each stage of the data lifecycle (from collection to removal)
Automate as much as you can, but keep humans in the loop
Farm out a specific task when you don’t have the resources to do it in-house
Related: Is Bad Data Hitting You Hard? Here’s How to Roll with the Punches
Keep in mind that data hygiene is a continuous process, not a one-time thing.
Always go back to the 5 F’s:
Find
Fix
Fill
Fit
Feed
Author Bio: Rebecca Matias is a Business Development Manager at Callbox. She is a proactive marketer who is willing to share her passion, leadership principles and craft in marketing. Follow Rebecca on Twitter, Facebook, and Google+.
|
{
"pile_set_name": "OpenWebText2"
}
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{
"pile_set_name": "Enron Emails"
}
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{
"pile_set_name": "OpenWebText2"
}
| 0.051282 |
Q:
ListView populates from the bottom instead of from the top
I have a listView that expands upwards instead of downwards.
I have another listView on another page that works just fine and populates itself from the top -> bot.
Why does my listView start from the bottom instead of the top?
My XML
`
<ListView
android:id="@+id/list_view_showRegister"
android:layout_width="fill_parent"
android:layout_height="wrap_content"
android:layout_above="@+id/showRegister"
android:layout_alignParentLeft="true"
android:layout_marginTop="50dp"
android:clickable="false" >
</ListView>`
A:
Your ListView is still actually populating from the top downwards. Just not from the top of the page.
You have set the layout_height="wrap_content" and the layout_above="@+id/showRegister". With the height being wrap_content, the view will only be as large as it's contents. Then, due to the fact you have used layout_above, it will be directly above another view.
The listview is not filling from the bottom, it is filling from the top (of the listview) - but the listview itself is only starting from halfway up the screen. Anything above the listview is not actually part of the listview, but empty space instead.
The solution is to either set the layout_height="match_parent", or remove the layout_above tag.
I know this is an old question but I hope this helps anyone else who may have found this issue via google.
A:
See for android:stackFromBottom attribute.
A:
Have a look a these links. Is it possible to make a ListView populate from the bottom?. populating from bottom.
Add new items to top of list view on Android?. Add new item at the top of list.
|
{
"pile_set_name": "StackExchange"
}
| 0 |
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{
"pile_set_name": "OpenWebText2"
}
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{
"pile_set_name": "Pile-CC"
}
| 0 |
Contamination and decontamination of rat and human skin with plutonium and uranium, studied with a Franz's chamber.
Our work offers a new method of assessing human skin radiocontamination and of appraising its treatment. This in vitro technique stems from methods used in skin pharmacology. Franz's diffusion chambers, which help maintain the physiological condition of a skin biopsy, are used to study how 233U and 239Pu, added to a 0.1 N solution of nitric acid, could enter skin. The efficiencies of two different decontaminating agents (Na3Ca)DTPA (25%) and EHBP (0.5 M) are compared. These studies were made on human skin samples, recovered after plastic surgery. Parallel experiments were carried out on hairless rat skin biopsies and on the skin of live hairless rats. Results in vivo and in vitro on the rat were not significantly different which validates the in vitro technique. In human beings, most of the radioactivity was found in the epidermis, with 2-4% found at the level of the dermis. By means of autoradiography we were able to identify that this radioactivity was concentrated in and around hair and sebaceous glands. Local treatments by EHBP seemed more efficient than those by DTPA in decorporating uranium and plutonium but the complexes radionuclide-EHBP seemed to diffuse through the skin more than the radionuclide-DTPA complexes if the skin was not rinsed after application of the chelating agent. This new in vitro technique using human skin has been validated for radiotoxicology. It can be used to quantify the diffusion of radionuclides through the various skin layers and to assess the efficiency of decontaminating agents.
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# This source code was written by the Go contributors.
# The master list of contributors is in the main Go distribution,
# visible at http://tip.golang.org/CONTRIBUTORS.
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Jan 27, 2013
Singapore - By-election result can't be taken as trend in future: Low Thia Khiang
SINGAPORE: Workers' Party (WP) chief Low Thia Khiang said the result of the
Punggol East by-election should not be seen as a trend for the future.
He said a by-election is
different from a general election.
He believes that in a
by-election, voters of Punggol East had no worries that they would
"accidentally throw out the government".
He said the message is very clear
that the role of WP is that of check and balance on the government.
"We give them time and we
don't agitate. I think the message got through and they gave us the mandate to
make sure that the People's Action Party does its job," said Mr Low.
Mr Low said the party has made it
clear that it is not ready to be the next or alternative government, as it has
limited resources and does not want to give Singaporeans false expectations.
He said the government is
competent but it needs to re-prioritise and address the issues related to costs
of living.
He said even though policies have
been reviewed, policy u-turns need time to take effect.
Mr Low said his party will play
its role in checking on the government but warned against politicising
everything.
He said that as a rational and
responsible party, WP should work with the government to bring about change and
improvements.
Mr Low, who spoke to reporters
before a thank-you parade in Punggol East on Sunday morning, said while
democracy is important for political vibrancy, it's not productive to
politicise everything.
The party will have seven elected
seats in Parliament, after its candidate, Ms Lee Li Lian, won the by-election
in the single-seat ward with 54.5 per cent of the vote share.
- CNA/fa
Business & Investment OpportunitiesSaigon Business Corporation Pte Ltd (SBC) is incorporated in Singapore since 1994. As Your Business Companion, we propose a range of services in Strategy, Investment and Management, focusing Health care and Life Science with expertise in ASEAN 's area.
We are currently changing the platform of www.yourvietnamexpert.com, if any request, please, contact directly Dr Christian SIODMAK, business strategist, owner and CEO of SBC at christian.siodmak@gmail.com. Many thanks.
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There's nothing more comfortable Then sleeping while someone gets ready for work
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Effect of loading on swelling-controlled drug release from hydrophobic polyelectrolyte gel beads.
The effect of oxprenolol HCl loading on the kinetics of polymer swelling and drug release from suspension-polymerized poly(methyl methacrylate-co-methacrylic acid) (PMMA/MAA) beads has been studied in detail. Within the range of variables studied, the polymer swelling rate increases with buffer pH and concentration. And an ionization-controlled swelling mechanism (analogous to the relaxation-controlled mechanism) mechanism) seems to become more rate-limiting at higher buffer concentrations. At oxprenolol HCL loading levels below 17.8%, the drug release and associated dimensional changes (in pH 7.4) exhibit an extended quasi-linear region despite the inherent limitation of spherical geometry. At higher loading levels, the drug release becomes faster and first-order in nature. This is apparently a result of the transition from a dissolved to a dispersed system above a percolation threshold (15-18% loading in the present study). As a result of competition from processes such as the reduction of bead dimension due to drug release and the dimensional increase due to polymer swelling and osmotic contributions from the drug, the transient bead diameter increases monotonically during drug release at loading levels up to 25.6%, whereas upon further increasing the drug loading, the bead diameter goes through a maximum during the early drug release, which eventually increases again as a result of the slow but continuous increase in polymer swelling due to further ionization. In all cases, both the drug release and the dimensional changes approach completion as the penetrating ionization fronts meet at the center, indicating a true swelling-controlled behavior.
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My Technology Adventure
Report snapshots older than X days in vROps
There are several ways to reporting snapshots. You can use PowerCLI, VRTools, or even vSphere Client itself. Today I will show you how to reporting by vRealize Operations Manager (vROps) 6.x. The benefit of vROps reports is you can schedule it by sending email with PDF & CSV reports. I found a post discuss how to reports by vROps. But it requests modify policy, it may impacts global calculation. What if your teams request different criteria for reports?
I noticed there is a bug in following view after finishing it. If you reporting snapshots older than X days but you delete the snapshot within X days and create a new one, VM will still show up in view! But I think it still valuable to publish this article since it’s a way to custom report in vROps.
Every report needs to associate with a view. So first step is create view. Login by admin account. Go to Views -> create a new view -> give name and description -> select List in Presentation step -> select Virtual Machine in Subjects step.
Data section is tricky. Select Snapshot Space (GB) under Disk Space metric -> Select Last in Transformation drop-list in Data tab -> Select Advanced in Time Settings -> Set Relative Start Date to Previous 4 Days and Relative End Date to Previous 3 Days -> Go to Filter tab -> Select Metrics in first drop-list, select metric Space|Snapshot|Virtual Machine Used (GB) in secondary drop-list, select is greater than in third drop-list, and set value to 0 in forth filed.
Select Last in Transformation drop-list in Data tab
Set Relative Start Date to Previous 4 Days and Relative End Date to Previous 3 Days
Transformation of metric Snapshot Space (GB) was set to last so it only shows last value in the selected time range. If value is 0 means no snapshot during the period. And time range was set to between previous 4 days to 3 days in steps above. It only shows the last value between last 4 to 3 days (It’s actual only one day). If the value is 0, we can take it as no snapshot before 3 days. If the value is greater than 0 means snapshot existing. In filter tab we filtered VMs by Snapshot | Virtual Machine Used (GB) is greater than 0. The metric value in filter tab is recent value according to my test. It filters the VMs out that don’t have snapshots.
Then just simply go next page by default settings and finish the view creation. You will be able to see a new view in the list. Next you need to create a report base upon the view. There are lot of articles in internet talk about that.
If I wanted vm’s with snapshots older than 20 days I’d set the relative start date to prev 21 days and the ending relative date to 20 days is that correct? I want a view/report that will give me snapshots older than 20 days. Please let me know what you think on this.
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| 0.056034 |
N-phenyl-p-phenylenediamine uptake onto reconstituted collagen fibrils.
N-Phenyl-p-phenylenediamine (N-PPDA) is known to cause strong skin irritation and a sensitization reaction in exposed persons. In a previous in vitro study with portions of skin, N-PPDA exhibited appreciable binding affinity, which suggests a likely involvement of collagen. The present study was therefore undertaken to assess the potential and kinetics of N-PPDA uptake onto collagen. A linear relationship between t-PPDA concentration and its uptake on collagen fibrils was observed. The higher the exposure or contact time the greater the uptake, until a saturation of available sites was reached. The binding was dependent on temperature, with greatest uptake noted at 35 degrees C, and a sharp decline observed at about 50 degrees C. The importance of the intact helical structure of collagen fibrils in offering optimal binding sites was evident from the diminished binding response of collagen denaturated by heat and urea and from the limited affinity towards gelatin. There appeared to be no involvement of sulphydryl groups in the N-PPDA uptake on collagen. A striking resemblance between the binding kinetics of t-PPDA onto collagen and that observed previously with skin portions in vitro, suggests that the collagen fibril model may have a use as a simple preliminary tool to screen chemicals that show binding potential towards skin, in order to make predictions about their dermal toxicity.
|
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| 0 |
As a valued Penna interim, we understand that more information regarding IR35 is a priority.
The Chancellor plans to continue with the legislation, despite our lobbying efforts and cross-sector resistance. Penna's ongoing priority is ensuring you are well-informed and able to work effectively. Accordingly, we have been working with the REC and HMRC to gain clarity on the impact and implications of this to our interim community.
Penna’s Executive Interim Team will be sharing these updates at our IR35 briefing sessions in London, Manchester and Birmingham during which you can network with your peers and ask questions.
|
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Luís de Sousa (writer)
Frei Luís de Sousa (born Manoel or Manuel de Sousa Coutinho; 1555 – 5 May 1632) was a Portuguese monk and prose-writer, born at Santarém, a member of the noble family of Sousa Coutinho.
Capture and release
In 1576, he broke off his studies at Coimbra University to join the order of Malta, and shortly afterwards was captured at sea by Barbary pirates and taken prisoner to Argel, where he met Cervantes. A year later, Manuel de Sousa Coutinho was ransomed, and landing on the coast of Aragon passed through Valencia, where he made the acquaintance of the poet Jaime Falcão, who seems to have inspired him with a taste for study and a quiet life.
The national disasters and family troubles increased his desire, which was confirmed when he returned to Portugal after the Battle of Alcácer Quibir. Between 1584 and 1586, he married a noble lady, Dona Magdalena de Vilhena, widow of Dom John of Portugal, the son of the poet Dom Manuel of Portugal, to whom Camões had dedicated his seventh ode.
In Portugal
Settling at Almada, on the Tagus opposite Lisbon, he divided his time between domestic affairs, literary studies and his military duties as colonel of a regiment. His patriotic dislike of the Philippine Dynasty grew stronger as he saw Portugal exploited by her powerful partner, and it was ultimately brought to a head in 1599. In that year, to escape the pest that devastated Lisbon, the governors of the kingdom for Philip II decided to move their quarters to his residence; thereupon, finding his protest against this arbitrary resolution unheeded, he set fire to his house, and to escape the consequences of his courageous act had to leave Portugal.
To Madrid
Going to Madrid, he not only escaped any penalty, owing no doubt to his position and influence at the Spanish court, but was able to pursue his literary studies in peace and to publish the works of his friend Jaime Falcão (Madrid, 1600).
Nothing is known of how he passed the next thirteen years, though there is a tradition that, at the instance of a brother resident in Panama, who held out the prospect of large commercial gains, he spent some time in America. It is said that fortune was unpropitious, and that this, together with the news of the death of his only child, Dona Anna de Noronha, caused his return home about 1604.
In 1613, he and his wife agreed to a separation, and he took the Dominican habit in the convent of Benfica, while Dona Magdalena entered the convent of the Sacramento at Alcantara. According to an old writer, the motive for their act was the news, brought by a pilgrim from Palestine that Dona Magdalena's first husband had survived the battle of Alcácer Quibir, in which he was supposed to have fallen, and still lived; Almeida Garrett has immortalized the legend in his 1843 play Frei Luís de Sousa. The story, however, deserves no credit, and a more natural explanation is that the pair took their resolution to leave the world for the cloister from motives of piety, though in the case of Manuel the captivity of his country and the loss of his daughter may have been contributory causes.
Writing
He made his profession on 8 September 1614, and took the name by which he is known as a writer, Frei Luís de Sousa. In 1616, on the death of Frei Luís Cacegas, another notable Dominican who had collected materials for a history of the order and for a life of the famous archbishop of Braga, Dom Bartholomew of the Martyrs, the task of writing these books was confided to Frei Luís. The Life of the Archbishop appeared in 1619, and the first part of the Chronicle of St Dominic in 1623, while the second and third parts appeared posthumously in 1662 and 1678; in addition he wrote, by order of the government, the Annals of D. John III., which were published by Alexandre Herculano in 1846. After a life of about nineteen years spent in religion, he died on 5 May 1632, in Benfica, Lisbon, leaving behind him a memory of strict observance and personal holiness.
The Chronicle of St Dominic and the Life of the Archbishop have the defect of most monastic writings—they relate for the most part only the good, and exaggerate it without scruple, and they admit all sorts of prodigies, so long as these tend to increase devotion. Briefly, these books are panegyrics, written for edification, and are not histories at all in the critical sense of the word. Their order and arrangement, however, are admirable, and the lucid, polished style, purity of diction, and simple, vivid descriptions, entitle Frei Luís de Sousa to rank as a great prose-writer. His metaphors are well chosen, and he employs on appropriate occasions familiar terms and locutions, and makes full use of those charming diminutives in which the Portuguese language is rich. His prose is characterized by elegance, sweetness and strength, and is remarkably free from the affectations and false rhetoric that characterized the age.
Poetry
In addition to his other gifts, Frei Luís de Sousa was a good Latin poet. There are many editions of the Life of the Archbishop, and it appeared in French (Paris, 1663, 1679 and 1825), in Italian (1727–1728), in Spanish (Madrid, 1645 and 1727) and in English (London, 1890). The História de S. Domingos may be read in a modern edition (6 vols, Lisbon, 1866).
Authorities
Obras de D. Francisco Alexandre Lobo, ii. 6f 171
Innocencio da Silva, Diccionario bibliographico portuguez, v. 327, xvi. 72
Dr Sousa Viterbo, Manoel de Sousa Coulinho (Lisbon, I902).
References
Encyclopædia Britannica article
Category:1555 births
Category:1632 deaths
Category:Portuguese male writers
Category:Portuguese Dominicans
Category:People from Santarém, Portugal
Category:16th-century Portuguese people
Category:17th-century Portuguese people
Category:Portuguese Roman Catholics
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| 0.055829 |
1. Introduction {#sec1-materials-10-01228}
===============
In endodontics, a range of materials are used to fill the root canal of a tooth after chemo-mechanical preparation has been completed. The root-filling material is expected to provide a hermetic seal against microorganisms \[[@B1-materials-10-01228]\]. It is typically applied in a plastic state which allows the filling of small anatomical intricacies of a tooth, however the change of state from plastic to rigid may be accompanied by a change in dimension \[[@B2-materials-10-01228]\]. A common approach to filling the root canal uses gutta percha (GP) cones \[[@B3-materials-10-01228]\] as a core material. These cannot provide a hermetic seal due to the lack of adhesion to dentine \[[@B4-materials-10-01228]\]. Because root canals are often irregularly shaped, these cones are heated to soften them to improve their adaptation to the canal walls. To help achieve complete obturation in three dimensions and provide a seal for the canal, the GP is combined with a sealer, typically consisting of epoxy resin \[[@B2-materials-10-01228],[@B4-materials-10-01228]\]. The entire filling is imperfect because thermo-plasticised GP shrinks upon cooling \[[@B5-materials-10-01228]\]. Moreover, cohesive fractures and voids are created when the epoxy resin sealer undergoes shrinkage as it polymerises \[[@B6-materials-10-01228],[@B7-materials-10-01228],[@B8-materials-10-01228]\]. Once coronal leakage has occurred, these voids create a pathway along which bacteria may penetrate through the root filling, for example through the sealer, along the walls of the root canal system, or at the interface between the GP core and resin cement \[[@B6-materials-10-01228],[@B8-materials-10-01228]\].
An alternative approach to obturation of the root canal would be to employ a single rigid cement material which is dimensionally stable and able to adapt to the canal walls and so obturate the entire root canal space \[[@B2-materials-10-01228]\]. Alkaline cements that release calcium hydroxide are of potential interest for this purpose, given the known benefits of calcium hydroxide pastes as antimicrobial agents when used to medicate the root canal system \[[@B9-materials-10-01228]\]. However, current calcium hydroxide-based sealers have poor resistance to bacterial leakage due to adaptability issues with canal walls and cement dissolution \[[@B10-materials-10-01228],[@B11-materials-10-01228]\].
Mineral trioxide aggregate (MTA) cements release calcium hydroxide as a reaction product. Rigid or hard-setting calcium hydroxide cements have also been developed without water in their composition to eliminate dehydration and subsequent shrinkage. These are based on the reactions of calcium hydroxide with glycerol. The set cement is a dense rigid material, within which freely available excess calcium hydroxide is trapped which has not been incorporated chemically into the set reaction products. Release of this excess calcium hydroxide can occur when water comes into contact with the surface of the set cement, but contact with water does not result in dissolution of the cement \[[@B12-materials-10-01228]\]. Release of hydroxide ions from these alkaline cements may exert antimicrobial actions, thereby reducing bacterial penetration along their interface with dentine \[[@B9-materials-10-01228]\]. The present study was undertaken to compare bacterial penetration through various cements, when faced with continuous exposure to salivary microorganisms in a rich broth environment using the bacterial penetration model described by Torabinajed et al. \[[@B13-materials-10-01228]\]. The working hypothesis for the study was that alkaline cements provide better resistance against bacterial penetration than the combination of GP with an epoxy resin cement.
2. Materials and Methods {#sec2-materials-10-01228}
========================
2.1. Collection and Preparation of Teeth {#sec2dot1-materials-10-01228}
----------------------------------------
Single-canal teeth with roots of comparable size and length were selected from a pool of extracted teeth collected from an oral surgery clinic with the approval of the institutional ethics committee (Approval code \#1311). Roots were inspected for cracks via transillumination with a handheld transilluminator (Microlux™, AdDent, Danbury, CT, USA) and discarded if a crack was found. The selected teeth were decoronated at the cemento-enamel junction, and the cut surface was flattened with a diamond bur to give samples of consistent length. The root canals were assessed for apical patency with a \#8 K-file (Dentsply Maillefer, Ballaigues, Switzerland). Any teeth with calcifications or blockages were discarded.
A total of 140 teeth were divided into 7 groups of 20 each by random assignment. The root canals were prepared with nickel-titanium rotary instruments, (ProTaper Next™, Dentsply Maillefer, Ballaigues, Switzerland) to size X3 with an ISO \#30 apical preparation and variable taper. The root canals were irrigated alternately with 1% *w*/*v* sodium hypochlorite (Endosure Hypochlor 1% Solution™, Dentalife, Melbourne, Australia) and 15% *w*/*v* ethylenediaminetetraacetic acid with 0.85% *w*/*v* cetrimide (Endosure EDTA/C 15% Solution™, Dentalife) using syringes with side-vented needles. After a final irrigation with EDTA/C, the canals were dried with paper points. The roots were then stored in saline at 22 °C until used.
2.2. Placement of Materials {#sec2dot2-materials-10-01228}
---------------------------
A total of five different materials ([Table 1](#materials-10-01228-t001){ref-type="table"}) were used to obturate the canals, with two groups serving as controls.
Both AH-Plus™ and Zirmix™ resin cements were used in conjunction with GP points to obturate the canal using the lateral condensation technique. Zirmix is a modification of the formula of an older product, AH26™, with only the bismuth trioxide replaced with zirconium dioxide to prevent staining of roots over time. A ProTaper Next™ X3 GP point (Dentsply Maillefer, Ballaigues, Switzerland) with a \#30 apical size and variable taper was used as the master cone, followed by medium and fine accessory points placed with the aid of a finger spreader.
Nex MTA™ (grey MTA), MTAmix™ (white MTA) and Supercal™ were used as single obturating materials. These materials were hand-mixed according to the manufacturer's instructions, then injected into the canal using a syringe with a fine nozzle under positive pressure and back-flowed from the apex. Complete obturation of all roots was confirmed using digital radiographs taken at 65 kV and 7 mA, with an exposure time of 0.16 s. Voids present in the obturation were eliminated by compaction of the cement with an endodontic plugger.
As positive controls, 20 roots had their canals left open to ensure bacterial penetration to the apical region. A further 20 roots were sealed at the coronal surface and at the apical third with molten red boxing wax, and served as a negative control to assess possible contamination in the model system used.
2.3 Mounting of Samples {#sec2dot3-materials-10-01228}
-----------------------
Pink nail varnish was used to coat the outer surface of all roots, other than for the coronal surface and the apical third. This was done to seal any unseen lateral canals or microscopic cracks. The roots were mounted in 5 mL specimen containers with an additional inverted lid which served as a reservoir for the growth medium containing bacteria from saliva. Holes were drilled into the lids and the roots secured in place through these holes with red boxing wax, as employed in previous studies \[[@B11-materials-10-01228],[@B13-materials-10-01228],[@B14-materials-10-01228]\]. The specimen assemblies ([Figure 1](#materials-10-01228-f001){ref-type="fig"}) were placed into an air-tight container and gamma irradiated with 25.4 kGy at a commercial gamma sterilisation facility (Steritech, Queensland, Australia).
Sterile brain-heart infusion (BHI) medium was prepared from stock powder (BBL Brain Heart Infusion™, Becton Dickinson, Franklin Lakes, NJ, USA) and loaded into the lower reservoirs of the sterilised specimen assemblies within a biosafety hood. The samples were then monitored over a 24 h period, to exclude those with environmental contamination.
2.4 Exposure to Bacteria {#sec2dot4-materials-10-01228}
------------------------
Fresh human saliva was collected daily for 90 consecutive days from a single healthy donor with the aid of paraffin wax (Saliva Test Buffer™ kit, GC Corporation, Tokyo, Japan) to stimulate saliva flow. A range of measures were undertaken to ensure consistency in the samples. Firstly, the samples were collected at the same time each day (6:00 p.m.). The subject did not use antibiotics or antimicrobial mouthwashes during the study, and followed an identical protocol for oral hygiene each day during the study. There was no oral hygiene undertaken in the 10 h prior to saliva collection, nor any foods or drinks in the 5 h prior to collection.
Immediately after collection, the saliva was mixed with sterile BHI medium in a 1:5 dilution, and the mixture placed into the uppermost inverted lid to expose the coronal surface of the roots to bacterial contamination. This mixture of saliva and BHI was replaced with a fresh inoculum each day for a total of 90 days or until bacterial penetration was identified. The daily inoculum was mixed thoroughly before application to the samples to ensure that the microbial challenge was the same. On each day, samples were taken of the salivary inoculum and were added to BHI broth, to check for growth using turbidity as a visual readout. The BHI salivary inoculum model was chosen to mimic an exposed root canal in the oral cavity. Prior studies using this model in the laboratory had shown that the salivary inoculum contained a diverse range of oral bacteria, as shown by Next-Gen sequencing \[[@B15-materials-10-01228]\].
The assemblies were kept in a fully humid environment at 37 °C in an incubator. Bacterial penetration was identified by turbidity in the BHI broth which contacted the apex of the tooth ([Figure 2](#materials-10-01228-f002){ref-type="fig"}). The time (in days) at which bacterial penetration occurred was used to plot survival curves.
2.5 Statistical Analysis {#sec2dot5-materials-10-01228}
------------------------
To assess bacterial penetration for the different materials, Kaplan--Meier survival curves were plotted. The median survival time (in days) to reach the point of bacterial penetration through 50% of samples was calculated for the various materials. Log-rank tests were used to assess the statistical significance of differences between materials, using a threshold of *p* \< 0.05.
3. Results {#sec3-materials-10-01228}
==========
All 20 positive controls consisting of roots with open canals failed by the second day. None of the test materials completely resisted bacterial penetration. Ranked from best performing to worst, Supercal™ had five surviving samples at the end of 90 days, followed by Nex MTA™ with two, and Zirmix™ and MTAmix™ each with one. All AH-Plus™ samples leaked within 48 days.
Kaplan--Meier survival curves are shown in [Figure 3](#materials-10-01228-f003){ref-type="fig"}. Median survival time (in days) for the various materials and corresponding P values of differences between materials are shown in [Table 2](#materials-10-01228-t002){ref-type="table"} and [Table 3](#materials-10-01228-t003){ref-type="table"}, respectively. Supercal™ was significantly better at resisting bacterial penetration than all other materials with the highest median survival of 28 days when exposed to salivary bacteria. Comparing the performance of materials of similar composition, within the epoxy resin cements Zirmix™ performed better than AH-Plus™ in terms of median survival, but this difference was not statistically significant (*p* = 0.4136). For the MTA cements, Nex MTA™ had a higher median survival than MTAmix™, and this difference was statistically significant (*p* = 0.0269) ([Table 3](#materials-10-01228-t003){ref-type="table"}).
4. Discussion {#sec4-materials-10-01228}
=============
The results of this study show that under the challenge of continuous exposure to salivary microorganisms in a nutrient-rich medium, none of the endodontic materials could completely prevent bacterial penetration through the root filling. The average time for microorganisms to pass through the root filling to reach the apex varied widely, with Supercal™ giving the longest time of four weeks. The time required for bacterial penetration was lower for epoxy resin cements than either for MTA or Supercal™. This may reflect the impact of polymerisation shrinkage during the setting reaction of epoxy resins \[[@B6-materials-10-01228],[@B7-materials-10-01228]\].
While both epoxy resin cements that were used with GP in the lateral condensation technique had similar composition, the performance of Zirmix™ was superior to that of AH-Plus™. Like AH26™, Zirmix™ is a powder-liquid system and was included in this study to assess its sealing ability against AH-Plus™ as an alternative non-staining epoxy resin cement. Zirmix is a modification of the formula of an older product, AH26™, with only the bismuth trioxide replaced with zirconium dioxide to prevent staining of roots over time. The results from this study are consistent with a past study that showed an inferior sealing ability of AH Plus™ compared to AH26™ \[[@B16-materials-10-01228]\]. Zmener et al. described the faster setting and more pronounced shrinkage stress of AH-Plus™ as being responsible for earlier de-bonding from dentine walls, hence greater bacterial penetration. Unlike AH26™, AH-Plus™ contains silicone oils that could prevent wetting of the root-canal wall and impair adhesion to humid dentine \[[@B16-materials-10-01228]\].
The present results revealed differences between the two MTA cements. When we examined samples of the cement powders using light microscopy, MTAmix contained larger and coarser particles than Nex MTA™. In a hand-mixed material, having larger particles may lead to greater porosity within the set cement, which then influences bacterial penetration. An additional observation was that all roots treated with Nex MTA™ showed intense grey discolouration. This a well-known issue with grey MTA cements \[[@B17-materials-10-01228]\]. No such changes were seen with MTAmix™, Supercal™, or the epoxy resin materials.
Some aspects of the continuous bacterial leakage model described by Torabinejad et al. \[[@B13-materials-10-01228]\] have been questioned in the literature, such as the ability of sticky wax to provide completely hermetic seal between the components of the model \[[@B18-materials-10-01228]\]. While it is possible that some leakage could occur at the sticky wax interface \[[@B18-materials-10-01228]\], this is not the only pathway, since leakage may also occur between the root filling and the canal wall. The present study used red boxing wax instead of sticky wax to seal the components to overcome any issues with brittleness of the wax, and also included controls to assess whether such leakage occurred. Nevertheless, as there was no thermal cycling it is not possible to extrapolate the bacterial penetration dynamics directly to the clinical situation, e.g., in terms of saliva contamination of a fractured tooth which has the root filling material exposed. Rather, the present study reveals differences in the performance of materials under the same testing conditions which provide information regarding their ability to resist bacterial contamination.
The results of the present study show that hard-setting alkaline cements that are dimensionally stable exhibit superior resistance to bacterial penetration. It is possible that the higher resistance of alkaline cements (i.e., MTA and Supercal™) to bacterial penetration could also be aided by the antimicrobial effects from calcium hydroxide released onto the root canal walls on contact with water. Hydroxide ions when present at high levels have antibacterial actions \[[@B12-materials-10-01228],[@B19-materials-10-01228]\]. Further investigations are necessary to assess the performance of calcium hydroxide-containing materials used as a hard-setting cement and the possibility of its use as a single agent for root filling.
5. Conclusions {#sec5-materials-10-01228}
==============
No root filling material was able to completely prevent bacterial penetration when faced with a constant challenge from salivary microorganisms. Within the timeframe and limits of this study, hard-setting alkaline cements based on MTA or calcium hydroxide show greater resistance to bacterial penetration than epoxy resin cements. However, the possible contribution of antimicrobial effects from hydroxide ion release should be investigated further.
Yu-Yao Teoh and Laurence J. Walsh conceived and designed the experiments and analysed the data; Basil Athanassiadis contributed reagents and materials; Yu-Yao Teoh performed the experiments and was supervised by Laurence J. Walsh and Basil Athanassiadis; both Yu-Yao Teoh and Laurence J. Walsh wrote the paper.
Basil Athanassiadis and Laurence J. Walsh are co-inventors of Supercal™, MTAmix™, and Zirmix™. The authors declare no other conflict of interest.
{#materials-10-01228-f001}
{#materials-10-01228-f002}
{#materials-10-01228-f003}
materials-10-01228-t001_Table 1
######
Experimental groups.
Material Manufacturer Description
----------- --------------------------------------------- --------------------------------------------------------------------------
AH-Plus™ Dentsply Maillefer, Ballaigues, Switzerland A non-staining epoxy resin two paste sealer.
Zirmix™ Ozdent, Castle Hill, Sydney, Australia A non-staining epoxy resin power/liquid sealer
Nex MTA™ GC Corporation, Tokyo, Japan A grey MTA cement
MTAmix™ Ozdent, Castle Hill, Sydney, Australia A white MTA cement
Supercal™ Ozdent, Castle Hill, Sydney, Australia A novel calcium hydroxide alkaline cement with a glycerol-based solvent.
materials-10-01228-t002_Table 2
######
Median survival in days for endodontic obturation materials and controls.
Material Median Survival (Days)
------------------ ------------------------
AH Plus™ 15.5
Zirmix™ 20.5
Nex MTA™ 11.0
MTAmix™ 6.0
Supercal™ 28.0
Positive control 1.0
materials-10-01228-t003_Table 3
######
Summary of differences between groups.
Material AH Plus Zirmix Nex MTA MTAmix Supercal Positive Control Negative Control
------------------ --------- -------- --------- -------- ---------- ------------------ ------------------
AH Plus \- 0.4136 0.2652 0.0144 0.0192 0.0001 0.0001
Zirmix \- \- 0.8156 0.0083 0.0771 0.0001 0.0001
Nex MTA \- \- \- 0.0269 0.1783 0.0001 0.0002
MTAmix \- \- \- \- 0.004 0.0001 0.0001
Supercal \- \- \- \- 0.0001 0.0196
Positive Control \- \- \- \- \- \- 0.0001
Negative Control \- \- \- \- \- \- \-
*p* values were determined from Log-Rank tests.
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