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5,100 |
PS 0036-0344
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5,101 |
Abstracts DGPPN 2007
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5,102 |
Einzelreferate und Buchbesprechungen
| null |
5,103 |
Abstracts der 45. Gemeinsamen Jahrestagung der DGIIN und ÖGIAIN
| null |
5,104 |
Mitteilungen der DGIM
| null |
5,105 |
Die Hypokotylfarbe als Markierungsfaktor von Genomstufen der Zuckerrübe
|
In zunehmendem Maße werden anisoploideBeta-Rübensorten angebaut, deren zytologische Kontrolle zwecks Feststellung der Genomstufenprozentanteile recht arbeitszeitaufwendig ist. Übereinstimmend mit polnischen Autoren wurde festgestellt, daß die Hypokotylfarbe ein geeigneter Markierungsfaktor für die einzelnen Genomstufen darstellt. Kreuzt man tetraploide Pflanzen, die ein grünes Hypokotyl besitzen, mit diploiden Pflanzen, die ein rosa Hypokotyl aufweisen, so erhält man von dem tetraploiden Partner tetraploide “grüne” und triploide “hellbraune”, von dem diploiden Partner diploide “rosa” und triploide “hellbraune” Nachkommenschaften. Die in bezug auf die Hypokotylfarbe heterozygoten Pflanzen kann man demnach von den homozygot “grünen” und homozygot “rosa” Individuen unterscheiden. Die Kreuzung diploid grünxtetraploid rosa ist für diese Zwecke nicht brauchbar, da sich die triploiden Heterozygoten mit einem “grünen” und zwei “rosa” Allelen in der Hypokotylfarbe nicht deutlich von den homozygoten “rosa” Pflanzen abheben. Auf die Bedeutung dieser Markierungsmöglichkeit für bestimmte Forschungsprobleme, die Züchtung und die Saatgutkontrolle wird hingewiesen.
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5,106 |
Union of Swiss Societies of Experimental Biology: Abstracts of the 16(th) Annual Meeting
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5,107 |
New from NPG
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5,108 |
Abstracts der Jahrestagung
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5,109 |
Mitteilungen der DGIM
| null |
5,110 |
News In Brief
| null |
5,111 |
How epidemics happen
| null |
5,112 |
Gentransfer mit adenoviralen Vektoren
|
Adenoviral vectors are promising vectors for somatic gene therapy in a number of inherited and acquired disorders. In this contribution, the current scientific knowledge as it relates to production and function of adenoviral vectors is summarized. The different types of adenoviral vectors are described and their respective advantages and disadvantages are delineated. Current problems with adenoviral vectors, and implications as they derive from the fatality observed in the Philadelphia gene therapy trial are discussed.
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5,113 |
Atemwegsinfektionen bei immunsupprimierten Personen
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Pulmonary infections in immunocompromised patients remain a diagnostic and therapeutic challenge.New methods for the early detection of fungal and viral diseases might allow an immediate and specific therapy, thereby lowering the high mortality associated with such infections.The development of new drugs will hopefully lead to more effective treatment while decreasing the incidence of adverse effects. Interdisciplinary team work between internal medicine, radiology, surgery, microbiology, and virology is essential for the successful management of these patients.
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5,114 |
Biomedical briefing
| null |
5,115 |
Hope and hype
| null |
5,116 |
Biomedical briefing
| null |
5,117 |
Notable advances 2012
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From the microbiome to the microenvironment, certain areas of biomedicine saw fast-paced discovery this year. Here's a rundown of the papers that helped these fields advance quickly in 2012.
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5,118 |
Einzelreferate und Buchbesprechungen
| null |
5,119 |
2003: The good, the bad and the unexpected
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5,120 |
Mitteilungen der DGIM
| null |
5,121 |
Oral Communications and Posters
| null |
5,122 |
News In Brief
| null |
5,123 |
Biomedical briefing
| null |
5,124 |
Abstracts des Kongresses für Kinder- und Jugendmedizin 2019
| null |
5,125 |
Abstracts der 110. Jahrestagung der Deutschen Gesellschaft für Kinder- und Jugendmedizin e.V. (DGKJ)
| null |
5,126 |
News in brief
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Timeline of events...a brief history of the important news stories this month
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5,127 |
Timeline of events: A brief history of what made news this year
|
Biomedical research in 2013 saw some dramatic developments, with unprecedented government action in the US ranging from the budget sequester in the spring to a dramatic government shutdown in autumn. But throughout the year, bright spots in science around the globe continued to dazzle, including multimillion-dollar partnerships to advance drug discovery and the go-ahead for highly anticipated trials of regenerative medicine.
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5,128 |
News in brief
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Timeline of events...a brief history of the important news stories this month
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5,129 |
News In Brief
| null |
5,130 |
Abstractband zum 119. Kongress der DGIM 2013
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5,131 |
Biomedical briefing
| null |
5,132 |
Abstracts der 46. Gemeinsamen Jahrestagung der DGIIN und ÖGIAIN
| null |
5,133 |
Falldefinitionen des Robert Koch-Instituts zur Übermittlung von Erkrankungs- oder Todesfällen und Nachweisen von Krankheitserregern § 4 (2) des Gesetzes zur Verhütung und Bekämpfung von Infektionskrankheiten beim Menschen (Infektionsschutzgesetz – IfSG): § 4 (2) des Gesetzes zur Verhütung und Bekämpfung von Infektionskrankheiten beim Menschen (Infektionsschutzgesetz – IfSG)
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5,134 |
Abstracts des Kongresses für Kinder- und Jugendmedizin 2018
| null |
5,135 |
Abstracts der 51. Gemeinsamen Jahrestagung der DGIIN und ÖGIAIN
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5,136 |
Abstracts der 48. Gemeinsamen Jahrestagung der DGIIN und ÖGIAIN. Der Mensch – ein anspruchsvoller Arbeitsplatz. 8.-10. Juni 2016 in Berlin, Estrel Berlin
| null |
5,137 |
Abstracts der 44. Jahrestagung der Gesellschaft für Neonatologie und Pädiatrische Intensivmedizin (GNPI): Gemeinsam mit der 26. Jahrestagung der Arbeitsgemeinschaft Neonatologie Mecklenburg-Vorpommern e. V.
| null |
5,138 |
News In Brief
| null |
5,139 |
Emerging infectious diseases
| null |
5,140 |
U. R. Fölsch
| null |
5,141 |
Mitteilungsseiten der DGIM
| null |
5,142 |
Plagues and people meet the microbe hunters
| null |
5,143 |
Mitteilungen der DGKJ und ÖGKJHK
| null |
5,144 |
64. wissenschaftliche Jahrestagung der GPOH
| null |
5,145 |
Hämovigilanz von Blutkomponenten Meldungen an das Paul-Ehrlich-Institut vom 1.1.1995 bis zum 15.11.1998: Meldungen an das Paul-Ehrlich-Institut vom 1.1.1995 bis zum 15.11.1998
|
In Germany cellular blood products are a licensed medicinal product. In the following we would like to present the reporting procedure, analysis and evaluation of suspected cases from spontaneously recorded data. During the time period from 1.1.95 until 1.1. 98 a total of 1488 suspected adverse events were reported in connection with cellular blood products and fresh plasma. In 1270 (85.34%) of these case reports viral transmissions were implicated, in 187 (12.56%) immunological transfusion reactions and in 31 (2.06%) bacterial infections. The case reports concerning viral transmission were further evaluated in a look-back-procedure according to the guidelines of the „Arbeitskreis Blut”, a working party on acute issues arising in the transfusion medicine area. In 864 (68%) of the 1270 cases the causality of the blood product could be excluded by re-testing the donor. In 118 cases (9.3%) infectious donors were subsequently identified; 21 were HIV-, 81 HCV- and 16 HBV transmissions. The reports were decoded according to year of treatment to differentiate those cases that occurred before the introduction of mandatory donor screening from those that occurred afterwards. 51 transmissions arose from the time prior to screening for viral antibodies. A total of 67 cases (3 HIV, 48 HCV, 16 HBV) can be traced back to the diagnostic window of each infection. In Germany transfusion reactions are most likely to be underreported compared to France or theUnited Kingdom. The frequency of infections that arose from cellular blood products is comparable to the remaining risk described in scientific literature.
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5,146 |
Abstracts der 41. Jahrestagung der Gesellschaft für Neonatologie und Pädiatrische Intensivmedizin
| null |
5,147 |
Einzelreferate Und Buchbesprechungen
| null |
5,148 |
Buchbesprechungen
| null |
5,149 |
Reviews and comment from the nature publishing group
| null |
5,150 |
Plavix fzzranchise in jeopardy
| null |
5,151 |
A comparison of oligonucleotide-based microarray and real-time PCR for the detection of sexually transmitted infections
|
Many diagnostic methods for sexually transmitted infections (STIs) have been developed. Because various infection agents are associated with STIs, and because infected persons sometimes show no symptoms, the diagnosis of STIs using nucleic acid amplification tests(NAATs) has required not only simultaneous multi-targeting, but also sensitive detection. Here, we compare microarray and real-time PCR for the detection of three common STIs agents, Ureaplasma urealyticum, Mycoplasma genitalium, and Chlamydia trachomatis, using human urine samples. The detection results showed that microarray and real-time PCR technology are both effective tools for the detection of STI agents. In conclusion, real-time PCR detection offers more sensitivity and specificity than microarray, because of the quantitative method employed. But, microarray offers better performance, in terms of high-throughput and simultaneous multi-targeting.
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5,152 |
Reviews and comment from the nature publishing group
| null |
5,153 |
Bovine Respiratory Disease in Finland
| null |
5,154 |
Cause of SARS still uncertain
| null |
5,155 |
SARS escaped Beijing lab twice
| null |
5,156 |
In the news
| null |
5,157 |
Latest SARS evidence
| null |
5,158 |
SARS-CoV ancestor found in Chinese bats
| null |
5,159 |
Reviews and comment from the nature publishing group
| null |
5,160 |
News in brief
| null |
5,161 |
Wednesday posters
| null |
5,162 |
Glucocorticoid contribution to lymphopaenia and immunpathology in patients with SARS
| null |
5,163 |
IN BRIEF
| null |
5,164 |
Genetics hits the headlines
| null |
5,165 |
Research Highlights
| null |
5,166 |
Thursday posters
| null |
5,167 |
In the News
| null |
5,168 |
Bat immunology takes off
| null |
5,169 |
News in Brief
| null |
5,170 |
In the news
| null |
5,171 |
Anthony Fauci
| null |
5,172 |
In the News
| null |
5,173 |
In Brief
| null |
5,174 |
In vitro estimation of metal-induced disturbance in chicken gut-oviduct chemokine circuit
|
BACKGROUNDS: Heavy metals affect various processes in the embryonic development. Embryonic fibroblasts (EFs) play key roles in the innate recognition and wound healing in reproductive tissues. METHODS: Based on the relative toxicities of different inorganic metals and inorganic nonmetallic compounds against murine and chicken EF cells, mechanistic estimations were performed based on transcriptomic analyses. RESULTS: Lead (II) acetate induced preferential injuries in the chicken EF and mechanistic analyses using transcriptome revealed that chemokine receptor-associated events are potently involved in metal-induced adverse actions. As an early sentinel of metal exposure, the precision-cut intestine slices (PCIS) induced the expression of chemokines including CXCLi1 or CXCLi2, which were potent gut-derived factors that activate chemokine receptors in reproductive organs after circulation. CONCLUSION: EF-selective metals can be estimated to trigger the chemokine circuit in the gut-reproductive axis of chickens. This in vitro methodology using PCIS-EF culture could be used as a promising alternate platform for the reproductive immunotoxicological assessment.
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5,175 |
Small scares
| null |
5,176 |
Erratum: Emerging regulation and functions of autophagy
| null |
5,177 |
T cells calm the storm
| null |
5,178 |
In Brief
| null |
5,179 |
3rd Winfocus Italian Congress, Bologna, Italy, 28–30 November 2009
| null |
5,180 |
In the News
| null |
5,181 |
Dix-huitième réunion du Comité local de la SPE à La Réunion, 15 mars 2011
| null |
5,182 |
Faster drugs for unknown bugs
| null |
5,183 |
Infections and perinatal diseases – a comparative overview
| null |
5,184 |
In the news
| null |
5,185 |
Novel coronavirus spreads
| null |
5,186 |
In the News
| null |
5,187 |
SARS unanswered questions
| null |
5,188 |
Reviews and comment from the nature publishing group
| null |
5,189 |
In the news
|
Our monthly round up of infectious diseases news, which this month includes inhibiting autophagy to target H5N1 influenza, how MRSA gained resistance down on the farm and 're-education' for the boy who cried outbreak.
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5,190 |
Research Highlights
| null |
5,191 |
In Brief
| null |
5,192 |
Structural genomics in the spotlight
|
Structural genomics efforts have spurred the continuing development of new methods and technologies, benefiting a broad community.
|
5,193 |
Expanding role for the apelin/APJ system in physiopathology
|
Apelin is a bioactive peptide known as the ligand of the G protein-coupled receptor APJ. Diverse active apelin peptides exist under the form of 13, 17 or 36 amino acids, originated from a common 77-amino-acid precursor. Both apelin and APJ mRNA are widely expressed in several rodent and human tissues and have functional effects in both the central nervous system and peripheral tissues. Apelin has been shown to be involved in the regulation of cardiovascular functions, fluid homeostasis, vessel formation and cell proliferation. More recently, apelin has been described as an adipocyte-secreted factor (adipokine), up-regulated in obesity. By acting as circulating hormone or paracrine factor, adipokines are involved in physiological regulations (fat depot development, energy storage, metabolism or eating behavior) or in the promotion of obesity-associated disorders (type 2 diabetes and cardiovascular dysfunctions). In this regard, expression of apelin gene in adipose tissue is increased by insulin and TNFα. This review will consider the main roles of apelin in physiopathology with particular attention on its role in energy balance regulation and in obesity-associated disorders.
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5,194 |
Prediction for Target Sites of Small Interfering RNA Duplexes in SARS Coronavirus
|
RNA interference is used for SARS-related pharmaceutical research and development. Following bioinformatic method twenty seven 21~25 base-long sequence segments in SARS-CoV genome are predicted as the optimal target sites of small interfering RNA duplexes.
|
5,195 |
Safety first
|
With a potential influenza pandemic looming, how practical is it to conduct vital experiments on emergent and often lethal pathogens?
|
5,196 |
Three decades of antiviral drugs
|
Thirty years ago, just three drugs were available for the treatment of viral infections, but now more than forty have been approved. What have been the guiding principles in these achievements and what might the future hold for antiviral drug development? SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/nrd2485) contains supplementary material, which is available to authorized users.
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5,197 |
Glucocorticoid treatment of patients with SARS: implications for mechanisms of immunopathology
| null |
5,198 |
Günter Witzany (ed): Viruses: essential agents of life: Springer, 2012, ISBN 978-94-007-4898-9
| null |
5,199 |
Abstracts of the EPSM-ABEC 2008 conference
| null |
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