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46,350,565
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.7748/ns.23.8.10.s14", "MAG": null, "PubMedCentral": null }, "license": null, "status": null, "url": null }
Automated stock cabinets storing medication and other essentials will be introduced in all wards and theatres at two London acute trusts following the completion of successful pilots.
2022-02-11T23:42:51.684Z
220,382,695
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1201/9781420068658-6", "MAG": "2491799472", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Other visible human characteristics tend to change fingerprints do not. Barring injuries or surgery causing deep scarring, or diseases such as leprosy damaging the formative layers of friction ridge skin (injuries, scarring and diseases tend to exhibit telltale indicators of unnatural change), finger and palm print features have never been shown to move about or change their unit relationship throughout the life of a person.
2022-09-15T09:16:48.389Z
39,454,278
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1097/00000478-200201000-00007", "MAG": "2039117750", "PubMedCentral": null }, "license": null, "status": null, "url": null }
We describe five primary soft tissue tumors that had histologic features identical to intraosseous aneurysmal bone cyst. The tumors occurred in three females and two males, who ranged in age from 8 to 37 years (median 28 years). They arose in the deep soft tissue of the upper extremities, thigh, and groin region and typically presented as a rapidly growing mass; no involvement of the adjacent bones was identified. The tumors ranged in size from 2.5 to 9 cm (median 4 cm). Grossly, they were surrounded by a thin rim of bone and on sectioning had hemorrhagic cystic spaces delineated by fibrous septa. Histologically, the cystic spaces were filled with blood and the fibrous septa were composed of fibroblasts, osteoclast-type giant cells, and woven bone. Cytogenetic analysis of one tumor showed 46,XY,t(17;17)(p13;q12), a result similar to that which has been reported for intraosseous aneurysmal bone cyst. The differential diagnosis includes a variety of bone-forming and giant cell-containing tumors, the most important being extraskeletal osteosarcoma. Follow-up showed that four patients are free of disease 16 months to 10 years after surgery; one tumor regrew after incomplete initial excision, but the patient has been free of disease 16 months after a second operation. Soft tissue aneurysmal bone cyst is an uncommon benign tumor that can be treated by simple excision, and it should be distinguished from a variety of other reactive and neoplastic processes.
2022-12-14T05:47:24.733Z
249,770,337
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1096/fasebj.2018.32.1_supplement.231.2", "MAG": null, "PubMedCentral": null }, "license": null, "status": "BRONZE", "url": "https://doi.org/10.1096/fasebj.2018.32.1_supplement.231.2" }
Among the air‐breathing vertebrates, the avian respiratory system is anatomically the most complex and physiologically the most efficient. Considerably, these attributes explain how and why birds achieved powered flight, a highly energetically costly form of locomotion. The avian lung which is small and rigid and firmly attached to the vertebral column and the ribs is ventilated continuously and unidirectionally by synchronized activity of capacious air sacs. Although the respiratory system has been studied for nearly five centuries, i.e. since Coiter (1573), certain aspects of its functional design remained unclear. The size, the shape and the arrangement of the blood capillaries and the air capillaries, the minuscule terminal respiratory units, particularly remained uncertain. Various investigators considered the air capillaries to be ‘tiny tubules', ‘intercapillary air passages', ‘straight tubules', ‘terminal air canals' and ‘intercellular passages'. Furthermore, the air capillaries were deemed to terminate in blind expansions, the blood capillaries were not mirror images of the air capillaries and the air capillaries and the blood capillaries run parallel to and in contact with each other across the exchange tissue. Because of the intimate entwining between the air capillaries and the blood capillaries, the exchange tissue was reported to resemble ‘a sponge in structure’, ‘a sinusoidal three‐dimensional network’ and ‘a dexterously crafted blood capillary network that interfaces with the equally complex air capillary labyrinth’. The descriptive (imprecise) terms used on the morphologies of the air capillaries and the blood capillaries and their topographical relationships were based on personal perceptions of microscopic sectional profiles rather than on hard empirical data. Unfortunately, the imprecise details were used in the formulation of a functional model for gas exchange in the avian lung where the air‐ and the blood capillaries were tubular in shape, the air capillaries run outwards from the parabronchial lumen and contacted the blood capillaries which run inwards from the peripherally located interparabronchial arteries and each of the respiratory units terminated blindly. Taking advantage of the recent increase in computing power and availability of appropriate robust software, three‐dimensional reconstruction was performed on serial sections of the avian lung to elucidate the morphologies and the spatial assemblage of the air capillaries and the blood capillaries. Unlike the classical morphology of the blood capillaries, e.g., in skeletal muscle, where the capillaries are longer than they are wide, those of the avian lung comprise distinctive segments that are rather as long as they are wide and are connected in three‐dimensions. The air capillaries are rotund structures which are joined by very narrow passageways. Completely isolated air capillaries were identified: the functional role of such units remains unclear. The air capillaries and the blood capillaries are not mirror images and the structural interdependence between the air capillaries and the blood capillaries may explain the strength of the tiny respiratory units. Because in a exchange tissue the air diffuses outwards from the parabronchial lumen and the blood flows inwards from the peripherally located interparabronchial arteries, existence of an auxiliary countercurrent arrangement was confirmed between the air capillaries and the blood capillaries.
2022-12-14T03:26:40.238Z
24,720,382
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1111/j.1550-7408.2004.tb00608.x", "MAG": "2175296616", "PubMedCentral": null }, "license": null, "status": "GREEN", "url": "https://europepmc.org/articles/pmc3109626?pdf=render" }
Abstract The genus Brachiola is the newest microsporidian genus established for a human infection with the type species being B. vesicularum in skeletal muscle. Subsequently, the microsporidium, Nosema algerae, identified from mosquitoes, was added to this genus because of morphological and physiological similarities. The present report illustrates a confirmed case of Brachiola algerae infecting skeletal muscle in a 56-year-old woman who was being treated for rheumatoid arthritis with immunosuppressive drugs. In the following study, these two human-infecting microsporidian species are ultrastructurally compared from human biopsy tissue. Additionally, Brachiola algerae from mosquitoes as reference B. algerae, was grown in athymic mice and compared to the human isolate in vivo, and in culture. B. algerae is morphologically identical in the host situations presented and different from B. vesicularum in human skeletal muscle. B. algerae has a consistently, slightly longer spore that typically contains one row of polar filament coils, while B. vesicularum typically contains two rows of polar filament coils and occasionally, one or three rows. In proliferative development, B. vesicularum forms protoplasmic extensions which do not occur on B. algerae, nor have they been reported on any other microsporidium. This report demonstrates that B. vesicularum and B. algerae are two different species of Brachiola that infect human skeletal muscle.
2022-12-14T12:31:30.788Z
25,062,919
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1097/00006123-199606000-00013", "MAG": "2031293006", "PubMedCentral": null }, "license": "implied-oa", "status": "HYBRID", "url": "https://journals.lww.com/neurosurgery/pages/default.aspx" }
Each of 20 consecutive patients with a history of at least 1 year of intractable chronic cervicobrachial pain was randomly assigned to one of two treatment groups. The pretreatment investigation included at least three diagnostic segmental nerve blocks in each patient. Each patient in Group 1 received a 67 degrees C radiofrequency lesion adjacent to the dorsal root ganglion. The patients in Group II were treated in an identical manner as those in Group I, except that no actual radiofrequency lesion was made. Neither the therapist nor the patients were aware of the treatment group assignment. All patients were questioned about their pain experience 1 week before and 8 weeks after the procedure. The following tests were used in evaluating patient response: Visual Analogue Scale (VAS); McGill Pain Questionnaire, Dutch Language Version (MPQ-DLV); and Multidimensional Pain Inventory, Dutch Language Version (MPI-DLV). These tests showed that 8 weeks after the procedure, there was a significant number of "successful" patients in Group I compared to Group II (P = 0.0027); there was a significant reduction in VAS score (P < 0.01) and also in parameters measured with MPQ-DLV and MPI-DLV in Group I. This study indicates that a 67 degrees C radiofrequency lesion adjacent to the dorsal root ganglion can result in a significant alleviation of pain in chronic cervicobrachial pain.
2022-12-16T08:43:04.336Z
145,422,222
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1044/CDS21.2.53", "MAG": "2109115610", "PubMedCentral": null }, "license": null, "status": null, "url": null }
The purpose of this article is to report the perceptions and experiences of family members of five African-American clients with aphasia as they accessed speech-language pathology services. Client ...
2022-12-16T00:41:03.762Z
210,983,284
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1097/TP.0000000000003012", "MAG": null, "PubMedCentral": null }, "license": null, "status": null, "url": null }
Kidney allograft failure is a serious condition, as it implies the need for reinitiation of dialysis with associated morbidity and mortality, reduced quality of life, and higher economic cost. Despite improvements in short-term survival of kidney allografts, this progress was not matched in long-term graft survival. In this viewpoint article, we summarize the available literature on the causes of kidney allograft failure, both early and late, both nonimmune and alloimmune, to gain better insight into the causes of graft failure. Such insight is necessary to better target therapies or take preventative measures that improve long-term outcome after kidney transplantation.
2023-01-01T05:35:09.190Z
149,281,698
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.22041/ijbme.2014.13534", "MAG": "2786190353", "PubMedCentral": null }, "license": null, "status": null, "url": null }
با توسعه­ی فناوری­های پیش­رفته در زمینه­ی ایمپلنت­های ستون فقرات، طراحی و ساخت کیج­های گردنی برای اولین بار در ایران مورد توجه قرار گرفته­است. این پروژه­ی تحقیقاتی صنعتی برمبنای مطالعات دقیق بیومکانیکی و براساس مدل­های عملکردی اجزای محدود و آزمایش­های مکانیکی مربوط به آن انجام می­شود. درین تحقیق، بهینه­سازی طراحی و مطالعه­ی بیومکانیکی تنها کیج گردنی بومی سازی شده در ایران (ساخت شرکت دانش­بنیان آتیلا ارتوپد) بررسی شد. بدین منظور، ابتدا مدل اجزای محدود گردنی (C2-C7) تهیه و محدوده­ی حرکتی آن با نتایج آزمایش­های آزمایشگاهی صحه­گذاری شد. سه پارامتر ابعادی به عنوان ورودی و دو پارامتر خروجی (شامل میزان تغییر شکل دندانه­های کیج در آزمایش استاتیکی و دینامیکی، طبق استاندارد ASTM F2077 برای فرآیند بهینه سازی طراحی و استفاده شد. سپس، تغییرات مورد نیاز جهت شبیه­سازی عمل جراحی هم­جوشی در سطح C5-C6 با جای­گذاری کیج گردنی انجام شد. درنهایت، نتایج مطالعه­های بیومکانیکی روی محصول نهایی کیج گردنی بومی­سازی ارائه شد. نتایج مطالعه­های بیومکانیکی نشان داد که این محصول به خوبی می­تواند در اعمال جراحی مورد استفاده قرار گرفته و مطابق با استانداردهای نمونه­های خارجی موجود در بازار، جهت کاربرد در جراحی­ها رقابت نماید.
2022-01-27T10:03:45.515Z
239,090,192
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.29309/tpmj/2016.23.05.1578", "MAG": null, "PubMedCentral": null }, "license": null, "status": "BRONZE", "url": "http://theprofesional.com/index.php/tpmj/article/download/1578/1281" }
Objective: To determine the risk factors, clinical manifestations, and diagnosticoutcome of stroke among patients admitted in CMH Jhelum. Study design: Descriptive caseseries. Place and duration of study: Medicine Department Combined Military Hospital JhelumCantonment from January 2013 to February 2014. Material and methods: A sample size of 200was obtained with an equal number of male and female patients. After formal consent a detailedhistory was taken regarding hypertension, diabetes mellitus, smoking, and Performa was filled.Investigations like Fasting blood sugar, serum cholesterol, and CT scan brain were also done,other relevant data like name, age, gender, and address, were collected. Patient admittedwith clinical presentation of stroke later being diagnosed on CT scan brain as ischemic orhemorrhagic were included. Stroke secondary to vascular lesions, space occupying lesions, andblood dyscrasias were excluded from study because these cases would act as effect modifierand interfere with results, thus producing bias in this study. Results: A total number of 200patients were included in this study with an equal ratio of male and female. Range of age groupwas 40 to 80 years while mean age group involved was 70.01 ± 13.02 years old. Most commonclinical manifestations were weakness of right half of the body that is 51.5%, weakness lefthalf 25%, and coma 13.5%. Hypertension found to be leading risk factor of stroke with 58.5%,while diabetes found in 24.5%, smoking 8%, obesity 5%, and high cholesterol in 4% of patients.Diagnostic outcome was ischemic stroke in most of the patients (71%) and hemorrhagic strokein 29%. Conclusion: Modifiable risk factors such as hypertension, diabetes, smoking, obesityand high cholesterol are found to the key risk factors. These can be easily controlled by life stylemodification and effective medication therapy resulting a significant reduction the morbidity andmortality of stroke.
2022-01-24T19:35:19.552Z
55,236,935
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.13005/BBRA/2678", "MAG": "2895124220", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Ayurveda contains a variety of medicines including the polyherbal fermented traditional medicines namely Arishta and Asava. It remains as a rich source of bioactive phytochemicals including antioxidants. There are scanty publications on the antioxidant activity of these medicines. There is a need to explore the natural antioxidants to replace synthetic counterparts which requires an assessment in terms of antioxidant activity by in vitro analysis. This study employs a range of antioxidant assay systems containing various free radicals (DPPH, hydroxyl, hydrogen peroxide, super oxide, nitric oxide and ABTS), Inhibition of free radical generation (metal chelating) and H+ – donating ability (reducing power) were performed. Ashokarishta, Aswagandharishta and Dasamoolarishta exhibited higher degree of antioxidant activities but less than the corresponding standards. Based on IC50 values, the hydrogen peroxide scavenging ability of Ashokarishta is comparable to the standard L-ascorbic acid. In ABTS assay, Aswagandharishta and Dasamoolarishta are comparable to the standard Butylated hydroxytoluene (BHT). These may be due to the phytochemical heterogeneity of the samples assayed. Thus study can lead to the sourcing of Ayuvedic polyherbal fermented medicines as a novel source of natural antioxidant molecules that might be acting as free radical quencher or scavenger and to treat human ailments.
2022-02-19T19:59:17.145Z
154,579,668
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.3188/SZF.2009.0371", "MAG": "2070759582", "PubMedCentral": null }, "license": null, "status": null, "url": null }
In this essay, the “efficiency” and “innovation” approaches to the reduction of foreseeable shortages of resources in the timber industry are critically considered. Efficiency gains and the resultant price reductions have led and still lead to an increase in consumption, whereby the savings achieved by the efficient use of resources are reduced (rebound effect) or even completely eaten up (backfire effect). Innovations also often result in increased use, as can be seen in the case of energy consumption. Two alternative conceptual and procedural approaches are presented in contrast to the concepts of efficiency and innovation: the consistency concept requires thought and action in cycles and the use of materials which fit in best with the natural cycles. The sufficiency concept envisages a reduction in the use of resources by means of the frugality of each individual. Humans as consumers are invited to consider critically and honestly their own lifestyle and their role in the current economic system.
2022-02-25T23:58:23.207Z
219,006,901
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.47144/PHJ.V53I1.1724", "MAG": "3022979454", "PubMedCentral": null }, "license": null, "status": null, "url": null }
OBJECTIVE: To study the proportion of positive exercise stress test in younger patients coming to tertiary care hospital for the evaluation of ischaemic heart disease (IHD). Our secondary objective was to find out the difference of risk profile between the relatively younger and elderly population having IHD. METHODOLOGY: This descriptive cross sectional study was conducted at cardiology department of a tertiary care centre at Karachi, Pakistan during July 1 st 2018 to December 31 st 2018 (six months). All adult patients whose exercise tests had been turned positive were selected for the study. Patients with history of arrhythmias, conduction defects, valvular heart diseases, co-morbid conditions like cirrhosis, stroke, osteoarthritis, chronic kidney disease were excluded from the study. The risk factors of interest were hypertension, diabetes Mellitus, smoking, lipid disorders and obesity. RESULTS: Total 85 patients were selected for the study. Out of them, 73 (85.9%) were male and 12 (14.1%) were female. Mean age of our patients was 56.2±8.7 years. Out of 85 patients, 33 (38.8 %) were falling into the category of younger (< 55 years) patients, while elderly (≥ 55years) patients were 52 (61.2%). In comparison to younger population, diabetes mellitus (34.6 vs 15.2 %; P-value = 0.04) and smoking (23.1 vs 6.1%; P-value= 0.03%) were significantly more prevalent in elderly individuals.  Prevalence of Hypertension was slightly higher in younger population (78.8 vs 73.1 %; P-value 0.5) as compare to elderly population. Similarly, younger population were found to be more obese (36.4 vs 28.8 %; P-value 0.4) as compared to elderly population. Prevalence of lipid disorder was almost equal between both the groups (40.4 vs 39.4%; P-value=0.9). CONCLUSION: The burden of Ischaemic heart disease is growing in our younger population and every third of our ischaemic patient is among the younger age group. Although proportion of diabetes and smoking is less common in younger population, trend of hypertension and obesity is on rise. KEY WORDS: Ischaemic Heart Disease, Younger Population, Coronary Risk factors
2022-07-04T09:42:26.996Z
155,560,767
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.2495/AIR000241", "MAG": "2292666683", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Brighton & Hove Council, University of Brighton and Ville de Amiens (France) joined together through European Interreg II funding created a project called 'Air Investigation and Research'. Part of this project is to inform the general public of the air quality around Brighton & Hove. Commissioning Abacus Research, the public's perception to air quality was sought through a market research study so that air quality information could be disseminated to the public in the format they would prefer. The objectives of the research were: to establish what air quality means to the public; gauge perceptions of current air quality communication methods and find alternatives; evaluate 'ATMO', the French air quality indices. Qualitative discussions preceded quantitative street interviews and a selfcompletion questionnaire. The results showed public confusion over what air quality is, how it is gauged and how it effects people. National and Local governments are considered lead authorities on air quality and they must provide the ignition to help the public to break their social routines regarding car travel. Monitoring air quality is considered necessary and the media and information boards are the most effective way to inform the public about air quality. However, these must be in a non-technical format. ATMO was found to be 'inappropriate' for England.
2022-09-02T10:55:41.559Z
251,495,305
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1017/S1352465822000297", "MAG": null, "PubMedCentral": null }, "license": null, "status": null, "url": null }
Abstract Background: Stigma against lesbian, gay, bisexual or queer (LGBQ) people may increase their risk of mental illness and reduce their access to and/or benefit from evidence-based psychological treatments. Little is known about the feasibility, acceptability and effectiveness of adapted psychological interventions for sexual minority individuals in the UK. Aims: To describe and evaluate a novel LGBQ Wellbeing group therapy for sexual minority adults experiencing common mental health problems, provided in a UK Improving Access to Psychological Therapies (IAPT) service. Method: An eight-session LGBQ Wellbeing group intervention was developed drawing on CBT and LGBQ affirmative principles. We compare the socio-demographic and clinical characteristics of patients who completed and dropped out of the groups, and explore changes in self-reported symptoms of depression, anxiety and functional impairment. Results: Over eight courses provided, 78 service-users attended at least one session, of whom 78.2% completed the intervention (drop-out rate 21.8%). Older participants were more likely to drop out. There was a lower proportion of female and bisexual or ethnic/racial minority individuals than would be expected. There were significant reductions in severity of depression, anxiety and functional impairment following the group, and more than half of those who completed the intervention needed no further treatment. Conclusions: There was preliminary evidence of the feasibility of, and potential clinical benefit in, a group therapy intervention for sexual minority adults experiencing common mental health problems. Future research should investigate access and outcomes for participants with additional social disadvantage, e.g. those who are female, older, bisexual or ethnic/racial minority.
2022-10-05T14:58:39.844Z
24,903,252
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1006/CIMM.1996.0150", "MAG": "2057977867", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Recent in vitro studies indicate that tumor necrosis factor (TNF) production in human monocytic THP-1 cells is suppressed by action of arachidonic acid metabolite prostaglandin-E2 (PGE2). PGE2 stimulation of human monocytic cell line THP-1 demonstrates that PGE2 not only regulates TNF activity at production levels, but does so through the release of two soluble TNF receptors (BP-55, BP-75) as well. PGE2 can thus exert a regulatory effect on TNF biologic activity by interfering with its ability to reach cell membrane receptors. THP-1 cells were activated with PGE2 for either 2- or 6-hr time periods, and the supernatants subsequently tested by ELISA to quantitate the levels of soluble receptor released. In addition, we examined mechanisms of receptor shedding by investigating the rate of membrane internalization and the role of serine proteases. PGE2-stimulated THP-1 cells showed soluble 55- and 75-kDa TNF receptor release levels which exceeded that of spontaneous release at both 2- and 6-hr activation periods. The numbers of both membrane TNF receptors were significantly upregulated as well in PGE2-activated cells, whereas the levels of 55- and 75-kDa TNF receptor mRNA levels remained unchanged. Thus, PGE2 induces TNF receptor release primarily at posttranscriptional levels. Inhibition of serine proteases with Pefabloc, a phenylmethylsulfonyl fluoride analog, resulted in the inhibition of both spontaneous and PGE2-stimulated release. Treatment of THP-1 cells with N-ethylmaleimide and low-temperature incubation, both known to block membrane internalization, also blocked spontaneous and PGE2-induced release. Internalization and cleavage by protease are therefore critical factors in PGE2-induced release of soluble TNF receptor shedding.
2022-12-10T09:22:12.157Z
154,318,407
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1111/1468-0084.00195", "MAG": "2049388867", "PubMedCentral": null }, "license": null, "status": "GREEN", "url": "https://documentos.fedea.net/pubs/eee/eee15.pdf" }
In this note we are concerned with the estimation of the probability that a smoker does not purchase tobacco during a survey. Usually, tobacco demand has been estimated using limited dependent variable models under the assumption that an important proportion of smokers declared a zero expenditure in tobacco. However, if the probability of non purchasing by a smoker is negligible, zeros could be ignored and the demand equation could be estimated on positive expenditure data using traditional estimation methods. Here we estimate this probability and find that it is extremely small. A novelty of this work is the use of data on the quantity and frequency of tobacco purchases during the week of the survey, instead of the more commonly used expenditure data.
2022-08-29T23:43:38.862Z
153,737,496
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.15057/7857", "MAG": "1566874213", "PubMedCentral": null }, "license": null, "status": null, "url": null }
This paper presents a "skyline" chart analysis of the Soviet, East European and major market economies, including the United States and Japan, in order to investigate the patterns and changes of the foreign trade of these countries from a comparative view. The investigation is limited to the period 1959 to 1977, because of the scarcity of current data. For certain countries, for example East Germany, there is a complete lack of official data, preventing us from making a comparative study involving these countries. As is well known, the "skyline" concept in input-output analysis was conceptualized by Leontief (1963) as a tool to study the structure of the economic development and foreign trade patterns of developing countries. We apply this concept to clarify foreign trade characteristics of the Soviet and East European economies. A primary reason for employing the "skyline" concept is that one of the most useful ways to see how these countries stand today is to construct a model of the economy as it would appear if it enjoyed self-sufficiency; namely, to determine the structure of production these economies would have to attain in order to maintain their present actual consumption and investment without access to foreign trade. The "skyline" chart graphically depicts these features, and also shows the degree of import and export activity of each economy.
2022-09-01T05:48:53.407Z
133,985,165
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.2172/115658", "MAG": "3023392385", "PubMedCentral": null }, "license": null, "status": "GREEN", "url": "https://digital.library.unt.edu/ark:/67531/metadc622447/m2/1/high_res_d/115658.pdf" }
The US Geological Survey and the Idaho Department of Water Resources, in response to a request from the US Department of Energy, sampled 19 sites as part of a long-term project to monitor water quality of the Snake River Plain aquifer from the southern boundary of the Idaho National Engineering Laboratory to the Hagerman area. Water samples were collected and analyzed for selected radionuclides, stable isotopes, inorganic constituents, and organic compounds. The samples were collected from seven irrigation wells, four domestic wells, two springs, one stock well, three dairy wells, one observation well, and one commercial well. Two quality assurance samples also were collected and analyzed. None of the radionuclide, inorganic constituent, or organic compound concentrations exceeded the established maximum contaminant levels for drinking water. Most of the radionuclide and inorganic constituent concentrations exceeded their respective reporting levels. All samples analyzed for surfactants and dissolved organic carbon had concentrations that equaled or exceeded their reporting levels. The ethylbenzene concentration in one water sample exceeded the reporting level.
2022-09-13T04:13:15.674Z
97,705,590
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1006/JSSC.1995.1065", "MAG": "2071783160", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Abstract Two new calcium thallates, CaTl 2 O 4 and Ca 2 Tl 2 O 5 , have been isolated that crystallize in the Cmcm space group with a = 3.3255(1) A, b = 11.022(1) A, and c = 10.479(1) A for the first and a = 3.3431(1) A, b = 11.159(1) A, and c = 13.499(1) A for the second. The ab initio determination of their structure from powder X-ray data shows that they are closely related and that they represent the first two members of a series with the generic formula Ca n Tl 2 O n +3 . In fact, the first member, CaTl 2 O 4 , is isotypic to CaTi 2 O 4 and can be described as a chemical twin of [Tl 2 O 4 ] ∞ rock salt layers, whereas the second member, Ca 2 Tl 2 O 5 , is derived from the first by increasing the thickness of the rock salt layers, i.e., by replacing double ribbons of edge-sharing octahedra by triple ribbons. In both structures, the chemical twinning is induced by the ability of calcium to adopt the trigonal prismatic coordination in prismatic tunnels; the direction of rock salt layer is invariable, i.e., parallel to the (113) plane of the cubic rock salt structure.
2022-09-15T01:30:32.178Z
95,059,174
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1021/MA00075A007", "MAG": "1992699143", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Novel methods for simulation of the chemical potential and for simulation of phase equilibria in systems of chain molecules have been developed. These methods are applied here to simulate Henrg's constants and solubility for linear alkanes in polyethylene. The results of our simulations are in good agreement with experiment. At moderate pressures,the solubility of an alkane in polyethylene exhibits strong deviations from ideal behavior, thereby rendering Henry's law of little use; our solubility simulations, however, are able to reproduce the experimentally observed saturation of the polymer by the alkane
2022-09-15T05:50:42.985Z
3,312,084
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1002/mds.27253", "MAG": "2770032035", "PubMedCentral": null }, "license": null, "status": "GREEN", "url": "https://europepmc.org/articles/pmc5809198?pdf=render" }
Background: We hypothesized that tonsillectomy modifies the risk of PD.
2022-12-19T08:15:42.226Z
13,462,907
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1073/PNAS.89.23.11486", "MAG": "2073100533", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Borna disease virus, an unclassified infectious agent, causes immune-mediated neurologic disease in a wide variety of animal hosts and may be involved in pathogenesis of selected neuropsychiatric diseases in man. Initial reports suggested that Borna disease virus is a single-stranded RNA virus. We describe here a method for isolation of viral particles that has allowed definitive identification of the genome as containing a negative-polarity RNA. Further, we show that the viral mRNAs are transcribed in the nucleus.
2022-12-26T19:55:28.339Z
22,219,555
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1111/j.1558-5646.1968.tb03473.x", "MAG": "2321858346", "PubMedCentral": null }, "license": null, "status": "BRONZE", "url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1558-5646.1968.tb03473.x" }
Euphrasia is a genus of green semiparasitic plants of the Tribe Rhinantheae of the family Scrophulariaceae; it is found in the Temperate Regions of both the Northern and Southern Hemispheres, and in both the Old and the New Worlds. The taxonomy of the genus was first placed on a firm footing by XVettstein's Monographie der Gattung Euphrasia (1896). Later contributions on similar lines have been those of Joergensen (1919), Fernald and Wiegand (1915), Pugsley (1930), Juzepcuk (1955), and Smejkal (1963). Apart from two Azorean species, the European Euphrasiae are annual herbs and belong either to the circumboreal Subsection Ciliatae (ciliate capsule, broad leaves with contiguous teeth-Fig. la, b) or the Subsection Angustifoliae (eciliate capsule, usually narrow leaves with distant teethFig. ic). In both groups the taxonomy is difficult owing to the smallness of the interspecific differences, the occurrence of intergradation and hybridization between species and the variability within them. All the species within each group thus appear very closely related. There are, however, many more species in Ciliatae than in Angustifoliae. Pugsley's figures (1936) for the two groups in their entirety, respectively 75 and 12 species, indicate their relative sizes. Pugsley (1936) arranged the numerous species of the Ciliatae into Series; these are listed in Table 1 with their chromosome numbers, where known (see Yeo, 1966), and a few representative species. No variation in chromosome number is known within Series. It will be seen that both diploid and tetraploid numbers, on a base of 11, occur. The diploid group, Series Hirtellae, was established by Pugsley (1930) before any chromosome counts had been made. We are thus presented with a diploid group and two rather divergent tetraploid groups.
2022-12-27T19:48:34.262Z
86,301,324
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1002/FEDR.19740850904", "MAG": "2127398288", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Fur die Namen von 22 Covolvulaceen-Gattungen (Amphione Raf., Aniseia Choisy, Breweria R. Br., Bucharea Raf., Dufourea H. B. K., Exocroa Raf., Exogonium Choisy, Fraxima Raf., Jacquemontia Choisy, Leptocallis G. Don, Modesta, Raf., Montejacquia Roberty, Nemostima Raf., Polymeria R. Br., Plesiagopus Raf., Reinwardtia Spr., Rhodorhiza Webb, Rhodoxylon Raf., Sanilum Raf., Sciadiara (Raf.) Jacks., Tirtalia Raf., Turpethum Raf.) wird die Lectotypenauswahl diskutiert. For 22 generic names of some Convolvulaceae (see above) the choice of lectotypes is discussed.
2022-02-10T22:30:47.710Z
59,399,404
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.31357/FESYMPO.V15I0.204", "MAG": "2283689888", "PubMedCentral": null }, "license": null, "status": null, "url": null }
The present study was conducted to identify the changes in nutrient contents in teak seedlings with the application of different types of nutrients along with compost. Compost was applied as compost alone, compost with calcium (Dolomite), with phosphorus (Triple Supper Phosphate, i.e, TSP) and with both calcium and phosphorus (Dolomite and TSP). In order to identify the nutrient changes; nitrogen, phosphorus, potassium, magnesium and calcium concentrations in leaves of teak seedlings under different treatments were analysed before and after 3 months of compost application. According to the results, nitrogen content in leaves of all treatments after 3 months of application were lower than that in leaves before the application of compost. The differences in phosphorus and potassium concentrations in leaves were the highest when compost was applied with TSP. The highest magnesium concentration was also observed under compost treatment with TSP. Among all the treatments, higher calcium differences were observed when compost was applied with both TSP and Dolomite, compost with Dolomite and compost with TSP respectively. The above observations showed that the application of different types of compost affect the nutrient contents of teak plants in different manner. However, application of compost with TSP showed the highest amounts of both potassium and magnesium amounts and a higher calcium amounts in plants.
2022-02-11T16:25:05.829Z
76,395,910
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.12701/YUJM.2002.19.1.55", "MAG": "2337465544", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Background: Interleukin-1(IL-1) and neutrophil appear to contribute to the pathogenesis of acute respiratory distress syndrome(ARDS). Elastase, as well as reactive oxygen species released from activated neutrophil, are thought to play pivotal roles in the experimental models of acute lung leak. This study investigated whether ICI 200,355, a synthetic elastase inhibitor, can attenuate acute lung injury induced by IL-1 in rats. Materials and Methods: We intratracheally instilled either saline or IL-1 with and without treatment of ICI 200,355 in rats. Lung lavage neutrophils, lung lavage cytokine-induced neutrophil chemoattractant(CINC) concentration, lung lavage protein concentration, lung myeloperoxidase(MPO) activity and lung leak index were measured at 5 hours of intratracheal treatment. Results: In rats given IL-1 intratracheally, lung lavage neutrophils, lung lavage CINC concentration, lung lavage protein concentration, lung MPO activity and lung leak index were higher. Intratracheal ICI 200,355 administration decreased lung lavage neutrophils, lung MFO activity and lung leak index, respectively, but did not decrease lung lavage CINC concentration. Conclusion: These results suggest that ICI 200,355 decreases lung inflammation and leak without decreasing lung lavage CINC concentration in rats given IL-1 intratracheally.
2022-02-11T06:26:16.134Z
56,340,053
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.15389/AGROBIOLOGY.2016.5.636ENG", "MAG": "2548023351", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Traditional obtaining of inbred lines and hybrids in sugar beet breeding requires a long time and is labour-consuming because of 2-year cycle of plant development, selfand cross-incompatibility, and inbreeding depression. To induce genotypic diversity in initial population, biotechnology methods including haploid parthenogenesis are promising. We have shown that, when inducing sugar beet (Beta vulgaris L.) haploids in vitro, express-diagnostics using phenotypic and embryological characters that are representative of periods of flowering shoots, organs and buds development, and stages of embryo sac, ovule and pollen grains formation is effective. The regenerative activity is observed in ovules of bud 1 to bud 25 located on ear part of pleochasium upward from the open flower. The nuclei and cells of female gametophyte of isolated ovules under in vitro conditions are capable of neoplasm at all stages of development, but the 8-nuclear or 7-celled embryo sacs are the most appropriate to morphogenesis and switching of development program from gametophyte to sporophyte type. Critical period of embryo sac development has been beforehand determined from the accompanying embryological characters — the presence of single-nuclear and two-three-celled pollen grains of anthers located in the same bud as ovules. The results we obtained indicate that hormonal composition of the Gamborg's B-5 (B5) medium is an important factor that effectively regulates direction of morphogenetic development in isolated ovules through direct regeneration (embryoidogenesis) or via callus (hemorhizogenesis) that is the evidence of totipotency of both sexual and somatic cells in the explant. The obtained data on in vitro reproduction of haploid regenerants add to available scientific notion of morphogenetic potential specificity in sugar beet plants. Stabilizing selection used to produce double haploids promotes detection of valuable morphological features of the regenerants. Determination of chromosome and chloroplast numbers in stomata guard cells as well as isozyme electrophoretic mobility (for Adh-1, Mdh-1, Mdh-2, Me-1, Idh-1, Idh-2, Gdh-1 loci) can serve as markers when inducing haploidy and producing homozygous restitution lines of sugar beet. Efficiency of RFLP-analysis method using Hind III restrictase that has allowed for the first time to identify haploid microclones according cytoplasm type is shown. Molecular markers have indicated that regenerants with normal cytoplasm (N) have one PCR-product of 800 bp in length not digested by Hind III. Two fragments (320 bp and 480 bp) of 800 bp product digestion are found in cytoplasmic male sterile (CMS) forms (S) that reflects combination of recessive and dominant genes. Obtaining haploid regenerants with sterile cytoplasm from initial population is of great theoretical and practical importance for sugar beet breeding thus facilitating the problem of producing homozygous lines with CMS and high-productive hybrids on the sterile basis.
2022-02-11T19:22:26.334Z
163,142,432
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1111/J.1095-9270.2002.TB01421.X", "MAG": "2169470747", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Figure I . Beams from Bryggen Bergen, from top nos 90371, 90469, 90426. The scale is 0.5 m. (Tracing by author from Egill Reimers’ field drawings) During the excavation, the fire layers were the mainstay of chronology, as most of the fires are reported in written sources (Herteig, 1991). In addition to logs coming straight from the forest, the foundations contain numerous reused timbers, both from houses and ships. Three reused beams are shown here as Figure 1 (nos 90371,90469,90426). No. 90371 is dated to layers from the rebuilding of the row of buildings known as GullskogArden after the fire in 1248. Accordingly, it must be older than its secondary use, how much older is difficult to say. On one side the beam has 15 triangular notches cut along the edges. The notches have been cut by three well-aimed blows from the upper corner of an axe. It has been published in connection with similar notches found in post-andbeam houses, and is regarded as somewhat of a puzzle by the authors (Schelderup & Storsletten, 2000). To me, there can be no doubt that this is what boatbuilders call a skordebjelke; the beam placed above the boat, parallel to the keel and used to support the upper
2022-02-08T21:24:17.908Z
96,576,853
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1002/JRS.1250210906", "MAG": "2070053094", "PubMedCentral": null }, "license": null, "status": null, "url": null }
The Raman spectra of tricyclopropylsilane were recorded for the condensed phases of this molecule, and infrared spectra (4000–400 cm−1) were obtained for all three states of this compound. In addition, a survey microwave spectrum of tricyclopropylsilane was recorded in the R-band region, and AM1 semi-empirical calculations were aslo undetaken for this molecule. Both the spectroscopic data and the theoretical results indicate that tricyclopropylsilane does not exhibit any low-energy structure having threefold symmetry. Instead, experimental evidence indicates the presence of at least two conformers of this molecule in the fluid phases, and only one of these conformers remains in the polycrystalline solid phase. The Raman and infrared spectra argue in favor of the fluid-phase tricyclopropylsilane conformers having the three cyclopropane rings arranged in a mixture of s–cis and gauche orientations relative to the SiH bond. These conclusions appear to be corroborated by the AM1 calculations, which indicate that the cis–cis–gauche rotamer of tricyclopropylsilane is the lowest in energy, followed by the cis–gauche–gauche and cis–gauche–gauche′ conformations, which are virtually equal in energy.
2022-07-31T11:43:17.385Z
225,915,538
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1088/1742-6596/1550/3/032082", "MAG": "3036427183", "PubMedCentral": null }, "license": null, "status": "GOLD", "url": "https://doi.org/10.1088/1742-6596/1550/3/032082" }
Topological Data Analysis (TDA) is a novel new and strong-growing method to deal with various data in most areas. And Persistent Homology is one of the most pivotal tools in Topological Data Analysis to acquire topological properties of the data. This article is based on the main mathematics behind Topological and Topological Data Analysis. And it describes how to use the above theories and methods to do the analysis job for time-series data. Moreover, it discusses the further applications of TDA to other domains and the combination of machine learning with Topological Data Analysis. The article outlines the TDA model and principle behind the data set and provides insights into the function of TDA for time-series analysis as well as opportunities for future work.
2022-07-31T20:12:34.915Z
225,389,464
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1039/d0se00189a", "MAG": "3046726368", "PubMedCentral": null }, "license": null, "status": null, "url": null }
New atom substitution in transition metals is a promising strategy for improving the performance of supercapacitors (SCs). Herein, we developed a cobalt sulfide core–shell nanostructure composed of nanoflakes and nanoparticles on a nickel foam substrate via a simple synthetic route involving CBD and subsequent sulfide ion-exchange reaction process. The resultant cobalt sulfide nanostructure exhibited enhanced charge transfer and provided abundant active sites with the electrolyte. Consequently, the unique core–shell cobalt sulfide nanostructure demonstrated a higher specific capacity of 450 mA h g−1 in comparison with that of cobalt oxide of 125 mA h g−1 and cobalt selenide of 337 mA h g−1 at a high current density of 5 mA cm−2. Moreover, the cobalt sulfide electrode delivered a good rate capability of 70% of its initial capacity. The core–shell structure of cobalt sulfide was further used to assemble an asymmetric hybrid supercapacitor (AHSC) with graphene ink as the outer electrode, showing a stable and high energy density of 35.43 W h kg−1 at a power density of 612.38 W kg−1, which is comparatively higher than that in recent works. The device exhibited superior cyclic stability of 96% over 5000 cycles. Our results suggest that the hollow core–shell structure is a simple strategy to fabricate high-performance advanced electrode materials for energy conversion and storage technologies.
2022-08-15T12:14:18.755Z
21,349,519
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1152/JN.2001.86.1.533", "MAG": "2296110671", "PubMedCentral": null }, "license": null, "status": null, "url": null }
In cat peroneus tertius muscles, static gamma axons were prepared in groups of three to four according to the conduction velocity of their axons (fast, intermediate, or slow). Effects of stimulating these groups (at 20, 30, and 50 Hz) on spindle ensemble discharges during sinusoidal stretch (peak-to-peak amplitude, 0.5 mm; frequency linearly increasing from 0.5 to 8 Hz in 10 s) were compared. Ensemble discharges were obtained by digital treatment of the discharges in afferent fibers from all the spindles in peroneus tertius as recorded from the muscle nerve. Stimulation of each group prevented ensemble discharges from falling to very low levels during shortening phases. However, this effect was clearly larger when the group of fast-conducting axons was stimulated. In view of the known effects of the activation of bag(2) and chain fibers (either separately or together) on single primary ending discharges during comparable sinusoidal stretches, this stronger effect supports the view that static gamma axons with faster conduction velocities are more likely to supply more bag(2) fibers than slower ones. Possibly the proportions of bag(2) and chain fibers activated during motor activity are determined by a recruitment of static gamma motoneurons related to their size.
2022-08-21T03:02:12.750Z
218,982,764
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.3390/ani10050918", "MAG": "3027038139", "PubMedCentral": "7278371" }, "license": "CCBY", "status": "GOLD", "url": "https://www.mdpi.com/2076-2615/10/5/918/pdf?version=1590629928" }
Simple Summary The histological examination of testicular tissue offers a suitable diagnostic method for investigating possible testicular causes of reduced fertility. A diagnostic measure of testicular health or function that does not impair fertility is needed. One possibility could be a needle biopsy of the testis. The testicular biopsy provides the attending veterinarian with a useful tool for plastic evidence of testicular infertility causes. Since the representativeness of this method in equine medicine was questioned, and has not been sufficiently answered in young bull calves so far, this study was carried out on male calves that were sent for slaughter. The aim of this study was to evaluate the significance of needle biopsy compared to en bloc resection. No differences between the individual locations of the tissue samples could be found. The results of the needle biopsy differ significantly from those of the tissue samples in almost all locations. This suggests that needle biopsy does not provide the same histological information as the tissue samples to determine the fertility status of the testes of bull calves. Abstract The aim of this study was to test whether a single testicular needle biopsy could provide histological results comparable to en bloc resection histology and whether one biopsy was sufficient to reflect the histology of an entire pair of testicles. Two methods of sample collection were tested on 32 bull calves aged five to eight months to compare histological parameters of needle biopsy with those of en bloc resection samples. One testicular needle biopsy of the right and three en bloc samples of both testicles were collected and compared for the number of tubular cross sections, tubules with elongated spermatids (ES), outer/inner diameter of tubules, thickness of tubular wall, and number of Sertoli cells (SC). Additionally, animal data were considered. No significant differences were found between the left and right testis or among the individual locations of en bloc samples. However, histologically significant differences (Bonferroni-adjusted significance level: p < 0.05/6 = 0.0083) were found between the needle biopsy and en bloc resection regarding the tubular cross sections per visual field (p < 0.05), the outer (p = 0.01) and inner diameter and the thickness of the tubular wall (both p < 0.01). In the SOX9 immunohistochemical staining, no significant differences (p > 0.05) could be observed for SC numbers between needle biopsy and en bloc samples. In conclusion, results of testicular needle biopsy do not have the same validity as the en bloc resection histology. Furthermore, one biopsy is insufficient to reflect the histology of the entire testicular pair.
2022-09-05T03:41:38.874Z
84,489,163
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.4314/AJCEM.V5I2.7377", "MAG": "2026505648", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Urine samples submitted to the Medical Microbiology diagnostic laboratory of the Ahmadu Bello University Teaching Hospital, Zaria, were routinely screened for Pseudomonas aeruginosa over a three-month period with 13/150 (8.67%) of the pathogenic bacteria isolated positively identified. All the isolates were resistant to the cheap, commonly available antibiotics; rifampicin, ampicillin/cloxacillin, erythromycin, chloramphenicol and ampicillin but were uniformly susceptible to ciprofloxacin. The high prevalence of multidrug resistance indicates a serious need for broad-based, local antimicrobial resistance surveillance for continuous tracking of antibiotic resistance trends among all clinically relevant isolates and introduction of effective interventions to reduce multidrug resistance in such pathogens. Key Words: Pseudomonas aeruginosa , antibiotic susceptibility, multiple antibiotic resistance, urinary tract infection Afr. J. Clin. Exper. Microbiol. 2004; 5(2): 198 – 202.
2022-09-09T05:44:56.135Z
97,365,940
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1021/MA9608986", "MAG": "2059424453", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Cp2Zr(13CH3)2 (1) has been used as a probe for the reactivity of metallocene−methylaluminoxane catalysts for olefin polymerization. A 1H and 13C NMR study of the reaction equilibria between Cp2Zr(13CH3)2 and Lewis acids such as AlMe3 (2), B(C6F5)3 (3), and methylaluminoxane (MAO) (4) has been performed. AlMe3 is always present in MAO solutions, and B(C6F5)3 is a relatively strong Lewis acid, which has a capacity to form and stabilize ion pairs comparable to that of MAO. The use of isotopically 13C-enriched dimethylzirconocene has permitted the study of these systems by 13C NMR in conditions as close as possible to usual polymerization conditions, which require large excesses of MAO for reaching high activities. The comparisons of the reactivity of Cp2Zr(13CH3)2 with B(C6F5)3 and with MAO have provided the first direct evidence of the formation in solution of monomeric [Cp2Zr(13CH3)]+[Me·MAO]- (8), of dimeric [Cp2Zr(13CH3)]2(μ-13CH3)+[Me·MAO]- (7), and of the [(Cp2Zr(μ-Me)2AlMe2]+[Me·MAO]- (9) cationic spe...
2022-09-15T04:09:12.204Z
51,865,148
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1002/art.40681", "MAG": "2887742796", "PubMedCentral": null }, "license": null, "status": "GREEN", "url": "https://europepmc.org/articles/pmc6261677?pdf=render" }
The advent of JAK inhibitors has provided a powerful new set of immunomodulatory agents to treat rheumatoid arthritis (RA). JAK inhibitors bind to and interfere with the function of Janus kinases (JAKs), which mediate signaling downstream of multiple cytokine and growth factor receptors(1). Given the wide range of cytokines that JAK inhibition can potentially influence, it is important to establish the dominant immunologic effects that these molecules exert in patients. In this issue of Arthritis and Rheumatology, Tanaka and colleagues describe the changes in circulating lymphocyte populations induced by baricitinib using data from 3 Phase 3 randomized controlled trials(2). By examining alterations in lymphocyte populations in over 2000 patients, with some patients followed for 2 years, the authors provide a robust set of observations that can be compared to experience with other JAK inhibitors and can yield insights into the effects of baricitinib on immune cell homeostasis. This article is protected by copyright. All rights reserved.
2022-09-30T01:11:46.671Z
58,605,452
{ "externalids": { "ACL": null, "ArXiv": "1805.02497", "DOI": "10.1063/1.5052219", "MAG": "2952463719", "PubMedCentral": null }, "license": null, "status": "GREEN", "url": "http://arxiv.org/pdf/1805.02497" }
Effects of multi-gradient fields on the transport of a polymer chain are investigated using Langevin dynamics simulations. We observe that the natural frequency of tumbling follows Wi 0.66 scaling, where Wi is the Weissenberg number. The distribution of angular tumbling time has exponentially decaying tails, and at high Wi, it deviates from Poisson behavior. Competition between the velocity gradient, which results in a shear flow in the system, and the solvent quality gradient arising due to the interaction among monomers reveals that there is another scaling associated with the angular tumbling time distribution. Moreover, at low temperature, we observe unusual behavior that at intermediate shear rates, the decay rate ν decreases with Wi.
2022-09-28T05:19:39.099Z
44,048,320
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1063/1.2035315", "MAG": "2147520566", "PubMedCentral": null }, "license": null, "status": "GREEN", "url": "https://pure.tue.nl/ws/files/2288469/Metis188702.pdf" }
We report on the experimental investigation of the photoconductively switched gas-filled spark gap. When the laser intensity of a femtosecond laser is high enough (around 1018Wm−2), a plasma can be created that spans the complete distance between the electrodes. The gas-filled spark gap is then closed on a femtosecond time scale, similar to photoconductive switching of a semiconductor switch. Stochastic breakdown processes, such as avalanche and streamer formation that cause the breakdown in laser triggered spark gaps, are passed over, which results in faster rise time and less jitter. Measurements of the switched pulses as a function of laser energy were performed in a 1-mm gap at an applied voltage of 4.5 kV. A clear transition from triggering to switching was measured with increased laser energy. Measurements of the output pulses with the gap filled with nitrogen at 1 atm showed results very similar to measurements in air in the same gap. In the switching regime, the amplitude of the switched pulse did...
2022-12-19T09:22:02.282Z
228,922,183
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.5937/LEKSIR2040013P", "MAG": "3101187216", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Driven by frequent media misinformation about the level of profitability of growing certain medicinal plants, in this paper we presented a cost-benefit analysis based on twenty years of experience in field production. The observed costs and profits for peppermint, chamomile, lemon balm, marshmallow, valerian and pot marigold are based on the average values of production elements within the current prices of labor, energy and raw materials. Fixed costs in this paper were deliberately neglected and the discussion was based on the assumption of the existence and availability of infrastructure. In the cost analysis, we divided them into four main groups, which had different shares in total costs such as labor 45-79 %, drying 5 – 37 %, material, 9-16 % and machinery use 4-13 %. Regarding the level of profitability of cultivation of the six observed medicinal plants valerian was the most profitable with an estimated profit of over 4000 €/ha. Next best earning plants were lemon balm and marshmallow with about 3500 €/ha, while the income from peppermint and chamomile was more than twice lower and it was around 1500 €/ha. The lowest profit was realized by cultivating marigold (about 600 €/ha) due to the high labor consumption on the flower picking operation. In terms of labor consumption marshmallow, pot marigold and valerian are the most demanding with 365, 285 and 150 working days per hectare, respectively. The general conclusion of this observation of the profitability of growing medicinal plants would be that the producer must be aware of the costs and scope of labor engagement he expects per unit area before embarking on the calculation of production.
2022-12-26T16:43:35.424Z
143,879,843
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.2466/pr0.1978.43.2.553", "MAG": "1995515906", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Although several investigators have used prompting and fading techniques to teach tasks with few or no errors, there has been disagreement about subsequent transfer and retention as compared with trial-and-error learning. Fourth grade students in an errorless fading condition learned a symbol discrimination task by a prompting and fading program in which relevant characteristics of the line drawings were emphasized. Another group learned the same discrimination by trial-and-error with right-and-wrong feedback. Findings indicated that percentage of errors was less for errorless fading than trial-and-error in initial learning but did not differ during transfer or retention. However, in terms of time, a history of prompting-fading learning did not transfer to trial-and-error learning as well as one of trial-and-error learning.
2022-09-10T22:04:14.534Z
6,933,734
{ "externalids": { "ACL": null, "ArXiv": "hep-th/9709201", "DOI": "10.1142/S0217751X99002086", "MAG": "2076197814", "PubMedCentral": null }, "license": null, "status": null, "url": null }
We exhibit the one-loop multigluon effective Lagrangian in any dimension for a field theory with a quasilocal background, using the background-field formalism. Specific results, including counterterms (up to 12 space–time dimensions), have been derived, applied to the Yang–Mills theory and found to be in agreement with other string-inspired approaches.
2022-09-21T11:19:56.895Z
16,729,202
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1109/CGIV.2007.51", "MAG": "2162553830", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Since the middle of 1990s, Malaysia has already showed its commitment and emphasis on the idea of Information and Communication Technology (ICT). Malaysia's Multimedia Super Corridor (MSC) is being developed in order to satisfy the country's ambition to achieve the fully developed status by the year 2020. Recent studies showed that online learning for secondary students had become more established and accepted as a standard way of learning nowadays. Educators are always being encouraged to incorporate technology into their classroom teaching. 3D interactions with multimedia elements relatively allow the learners to learn and grasp the lessons being taught much faster than in a normal classroom. The use of computer training tools where the student can interact with a computer model can give good feedbacks. 3D analytical approach is especially useful in determining the fundamental molecular events using a Web-based, visually-oriented system that allows efficient querying of gene expression. The implementation of VRML is perceivably efficient and effective method for conveying molecular models over the net. In molecular science, 3D impressions and conceptions are elementary in order to transfer and understand further complex structural information. A prototype of an interactive 3D multimedia learning tool in Biology was created in order to provide users with a 3D element multimedia study environment in Biology subject. The prototype contains three main divisions which are the 3DiC, animations and tutorials. It allows users to learn and study about the biological cells and animations in an interactive and interesting 3D environment.
2022-12-03T04:48:57.862Z
7,397,530
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.5489/cuaj.1989", "MAG": "1879718348", "PubMedCentral": null }, "license": null, "status": "BRONZE", "url": "https://cuaj.ca/index.php/journal/article/download/1989/1890" }
INTRODUCTION We assess the effectiveness of intravesical instillation of hyaluronic acid (HA) and chondroitin sulphate (CS) as a non-antibiotic treatment option for prophylaxis of recurrent urinary tract infections (UTIs) in female patients. METHODS This was a retrospective cohort study involving 7 European institutions. We included patients with recurrent UTIs who received intravesical instillations of Ialuril (IBSA International) (50 mL HA 1.6% and CS 2% solution) between January 2010 and March 2012. Medication schedule, length of follow-up, recurrence infection time, number of UTIs/patients/year, patient quality of life, subjective symptoms score, and treatment-emergent side effects were recorded and analyzed. RESULTS In total, 157 women (mean age: 54.2 ± 4.1 years) were included in the analysis. All patients had at least 12 months follow-up. After 4 weekly and 5 monthly HA-CS bladder instillations, UTI episodes decreased from 4.13 ± 1.14 to 0.44 ± 0.50 (p = 0.01) at 12 months, while recurrent UTI time prolonged from 94.8 ± 25.1 days to 178.4 ± 37.3 days (p = 0.01) at 12 months. An improvement in symptoms and quality of life was achieved. A medium-depth pain after medication instillation was the most reported side effect. Regression model analysis showed significant risk factors in developing new UTI episodes: being more than 50 years old and having more than 4 UTI episodes per year (OR 3.41; CI 95%; 1.51-7.71, p = 0.003 and OR 3.31; CI 95% 1.51-7.22; p = 0.003, respectively). Retrospective design and lack of a control group represent two main limitations of the study. CONCLUSIONS Restoring glycosaminoglycans bladder layer therapy is a promising non-antibiotic therapy to prevent recurrent UTIs.
2022-12-10T09:57:42.242Z
222,005,276
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.2478/mgrsd-2020-0025", "MAG": "3087794151", "PubMedCentral": null }, "license": "CCBYNCND", "status": "GOLD", "url": "https://www.sciendo.com/pdf/10.2478/mgrsd-2020-0025" }
Abstract The objective of this paper is to describe bioclimatic conditions in Lublin and Radawiec in the period 1976–2015 using the UTCI index. The paper shows that in Lublin and Radawiec, the most frequent biometeorological conditions caused no heat stress and were neutral for the human organism. At the analysed stations, biometeorological conditions causing cold stress occurred more frequently than those causing heat stress. Biometeorological conditions in the analysed period were characterised by high year-to-year variability. We observed that in recent years there was an increase in frequency of conditions favouring heat stress and a decrease in conditions favouring cold stress.
2022-12-10T10:15:47.546Z
19,685,130
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1039/c4cp00349g", "MAG": "2063483030", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Self-healing is the ability of a material to repair mechanical damage. The lifetime of a coating or film might be lengthened with this capacity. Water enabled self-healing of polyelectrolyte multilayers has been reported, using systems that grow via the interdiffusion of polyelectrolyte chains. Due to high mobility of the polyelectrolyte chains within the assembly, it is possible for lateral diffusion to heal over scratches. The influence of metal ions and nanoparticles on this property has, however, not been previously studied. Here we demonstrate that the incorporation of silver nanoparticles reduced in situ within the branched poly(ethyleneimine)-poly(acrylic acid) polyelectrolyte multilayer structure speeds the ability of the multilayer assembly to self-heal. This enhancement of property seems to not be due to changes in mechanical properties but rather in enhanced affinity to water and plasticization that enables the film to better swell.
2022-12-18T15:12:30.956Z
137,594,270
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1109/KORUS.2000.866113", "MAG": "1673574314", "PubMedCentral": null }, "license": null, "status": null, "url": null }
The thermo-vision technique is suggested to control the lining conditions, mainly its thermal conductivity. The technique comprises the IR imagery of steel-melting aggregate, the determination of the temperature field of observed surface and the comparison the measured temperatures with permissible technological values,
2022-12-20T12:50:48.704Z
19,236,259
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1126/science.255.5045.714", "MAG": "2030421686", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Nuclear magnetic resonance (NMR) spatial imaging data may be acquired, processed, and interpreted in ways that provide information directly analogous to diffraction experiments, with length scales determined by gradient strengths rather than radiation wavelengths. This approach, originally considered by Mansfield nearly two decades ago, provides access to autocorrelations of sample density that statistically characterize small-scale density variations. These NMR "Patterson functions" can be acquired orders of magnitude more rapidly than comparably resolved NMR images and are suitable for spatial characterization of small features in bulk samples, such as morphology in structural materials. Unlike hindered diffusion approaches, neither mobility, penetrants, nor transport time are required for examining granularity and porosity.
2022-12-21T09:42:34.244Z
234,135,907
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1051/E3SCONF/202124411055", "MAG": "3138655378", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Race speed is one of the main indicators by which trotting horses are estimated. In addition to the horse genotype, race speed is also determined by the influence of environmental factors, such as feeding, keeping, training, and testing conditions. These conditions include of race track surface condition, the rider’s qualifications, season of the year, weather conditions. In this paper the influence of race track surface condition on the accuracy of assessing race time is considered. The data of horse trials of Orlov trotters at the Moscow hippodrome were used. The race time of 256 horses at a distance of 1600 m was assessed. Depending on the weather conditions and the track surface, 9 different track conditions were identified. For the analysis we used data on stallions and mares aged 4 years and older without disaggregation by sex, since there were no significant differences between the average race speed of stallions and mares and it was shown that it was the horses of the older age group that were reliably characterized by the highest average race time with minimal races per horse. It was found that the strength of the influence of the variety of race tracks on the variety of assessments of race time is reliable and amounted to 23.5%. When analyzing the group of the fastest horses, this indicator turned out to be higher and amounts to 43.8%. It is also shown that the selection of horses for breeding work is more expedient and accurate to carry out according to the average race time of the horse for a number of races, and not according to its best result, since in this case the stability of performances is not taken into account.
2022-06-14T05:06:39.138Z
144,106,124
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.2514/6.2010-9154", "MAG": "2013652228", "PubMedCentral": null }, "license": null, "status": "GREEN", "url": "https://pure.manchester.ac.uk/ws/files/32995755/FULL_TEXT.PDF" }
The University of Manchester was created in 2004 through the merger of the Victoria University of Manchester (VUM) and the University of Manchester Institute of Science & Technology (UMIST). Both of the constituent universities had an undergraduate aerospace engineering program. The combination of the two undergraduate programs along with the development and initiation of a post-graduate Master of Science program required a reassessment of the design units at the university. As such the current aerospace engineering curriculum has evolved and is continuing to evolve from those of it predecessors and the development and inclusion of new course material. This evolution has included a restructuring of unit contents, an increased focus on defending design decisions and the breadth of the systems design process. The changes to date have focused on the 3rd and 4th years of the BEng and MEng programs respectively and the inclusion of MSc students. Future work will incorporate changes to the 1st and 2nd years along with further changes to the existing units.
2022-07-04T09:29:57.707Z
28,004,824
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1097/SCS.0b013e3182418cc9", "MAG": "1979020146", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Retrobulbar hematoma is a rare condition but represents a diagnostic and therapeutic emergency. It occurs in between 0.3% and 3.5% of facial traumas and can be caused by direct or indirect injury of the orbit; they can be classified into intraorbital and subperiosteal hematoma. We describe 4 different cases of posttraumatic retrobulbar hematoma treated at the Unit of Maxillofacial Surgery of the Novara Major Hospital between January 2005 and December 2009, each different from the others for morphologic aspects, and we discuss its diagnosis and management. Surgery decompression of the orbit is recommended when visual deficit arises and when there is no response to pharmacologic therapy. Several techniques for orbital decompression have been proposed. The lateral canthotomy and/or the inferior cantholysis are the 2 techniques most practiced. Anterior-chamber paracentesis is effective, but it is rarely indicated for frequent complications such as cataract formation, herniation of the iris, infection, and trauma to the canal of Schlemm. Other procedures including transantral ethmoidectomy, transantral sphenoidectomy, and transfrontal craniotomy are described.
2022-09-10T10:40:39.519Z
108,873,188
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.2118/56880-MS", "MAG": "1969382494", "PubMedCentral": null }, "license": null, "status": null, "url": null }
This paper evaluates the maximum flow rate before the sand production initiates while flowing back a reservoir after the hydraulic fracturing treatment. The experiments are performed in a high pressure slot which simulates a fracture. The slot is a parallel plate device, which is 7 ft high and 9 1/3 ft long with provisions for varying fracture gap width. The slot is filled with proppant to simulate a propped fracture, then, the closure pressure is applied with 12 actuators to simulate confining pressure on the proppant pack. Water is pumped into the slot to simulate flowing back of the fracturing fluid. The water flow rate is varied till the proppant pack destabilizes, and the sand production begins. The sand distribution is observed in the fracture with a vision system. The experimental results show that the critical water flowback rate decreases as the closure pressure increases, or when the fracture gap width increases. However, the sand-free maximum water flow rate increases as the sand size increases for a given fracture gap width. Lastly, the cumulative sand production decreases as the closure stress decreases at a particular flow rate. The visual observations of the proppant flowback phenomena show that the sand production initiates close to the perforation. After the initiation of the sand flow, continued pumping of the water results in sand production through a channel formed in the proppant pack.
2022-09-11T23:06:11.144Z
208,980,955
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.5964/jspp.v7i2.1032", "MAG": "2987373661", "PubMedCentral": null }, "license": "CCBY", "status": "GOLD", "url": "https://doi.org/10.5964/jspp.v7i2.1032" }
Decision making is not always a reasoned process. It is often subject to reflexive heuristics. The Moral Foundations Theory is a popular theoretical framework that characterises political decisions by adherence to an evolutionary criterion. Based on recurrent ancestral pressures, this model anticipates our species’ tribal history has resulted in a set of intuitive ethics: Care/ Harm, Fairness/ Cheating, Loyalty/ Betrayal, Authority/ Subversion, and Sanctity/ Degradation. Focusing on the winning side, this paper analyses official communications, polling data and media coverage to explore how the Leave campaigners intentionally or unintentionally appealed to the public’s moral intuitions. In doing so, it aims to show why evolutionary psychology potentially offers a useful layer of analysis with which to understand contemporary politics.
2022-09-08T16:02:34.014Z
19,094,457
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1177/000348949710600707", "MAG": "2046189538", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Eighth nerve sections have been performed to control debilitating tinnitus, with various success rates (45% to 76%). Patients with a unilateral profound sensorineural hearing loss and disabling tinnitus perceived in that ear are candidates for such surgery. The concept of a selective cochlear neurectomy with preservation of the vestibular nerve is introduced with two case presentations. The indications for surgery, surgical technique, and results are described. Advantages of preserving the vestibular nerve fibers include the lack of postoperative vertigo and disequilibrium and thus a shorter length of hospital stay, and the conservation of a symmetric vestibular input, obviating the lengthy compensation process that might otherwise be needed, particularly in the elderly. A selective cochlear neurectomy for the control of debilitating tinnitus has proven to be successful in controlling tinnitus in the two patients presented, with the added advantage of preservation of their vestibular function. Further controlled studies are necessary to confirm the advantages and effectiveness of this technique.
2022-12-09T09:21:48.235Z
250,669,368
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1088/1742-6596/219/3/032065", "MAG": null, "PubMedCentral": null }, "license": null, "status": "GOLD", "url": "https://doi.org/10.1088/1742-6596/219/3/032065" }
One of the main components of the CMS experiment is the Silicon Tracker. This device, designed to measure the trajectories of charged particles, is composed of approximately 16,000 planar silicon detector modules, which makes it the biggest of its kind. However, systematic measurement errors, caused by unavoidable inaccuracies in the construction and assembly phase, reduce the precision of the measurements significantly. The geometrical corrections that are therefore required have to be known to an accuracy that is better than the intrinsic resolution of the detector modules. The Kalman Alignment Algorithm is a novel approach to extract a set of alignment constants from a large collection of recorded particle tracks, and is applicable for a system even as big as the CMS Tracker. To show that the method is functional and well understood, and thus suitable for the data-taking period of the CMS experiment, two case studies are presented and discussed here.
2022-12-10T02:01:18.836Z
46,871,919
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1159/000242910", "MAG": "2022100990", "PubMedCentral": null }, "license": null, "status": null, "url": null }
The incorporation of 14C-glucosamine into glycoproteins (GP) and glycosaminoglycans (GAG), of 3H-leucine into protein, and the hexuronic acid (HA) content of polymerized GAG was determined in incubated placental tissue. In placentae of earlier gestational age (GA), incorporation of 14C-glucosamine was 2.6 times greater than other at 38-39 weeks GA. 19 of 26 placentae at 38-39 weeks GA responded by one or more parameters when incubated with 0.5-3 microM 17 alpha-OH-progesterone (17OHP). Those which did not respond were all of earlier GA; the placental content of GAG decreased in these from 31.1 +/- 1.8 nmol HA/mg protein to 16.4 +/- 1.5 nmol in placentae of GA 38-39 weeks. In the latter, 17OHP increased GAG by 42.5% to 24.4 +/- 2.5 nmol HA/mg protein in a 2-hour incubation. Progesterone, oestriol, cortisol and testosterone were without effect. It is concluded that synthesis of placental GAG decreases toward the end of gestation, but can be increased by 17OHP specifically. This indicates that 17OHP is a biologically active steroid and might have a role in maintaining placental function.
2022-12-09T10:34:25.972Z
23,741,752
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1520/JFS2003179", "MAG": "2003345999", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Robotic systems are commonly utilized for the extraction of database samples. However, the application of robotic extraction to forensic casework samples is a more daunting task. Such a system must be versatile enough to accommodate a wide range of samples that may contain greatly varying amounts of DNA, but it must also pose no more risk of contamination than the manual DNA extraction methods. This study demonstrates that the BioMek 2000 Laboratory Automation Workstation, used in combination with the DNA IQ System, is versatile enough to accommodate the wide range of samples typically encountered by a crime laboratory. The use of a silica coated paramagnetic resin, as with the DNA IQ System, facilitates the adaptation of an open well, hands off, robotic system to the extraction of casework samples since no filtration or centrifugation steps are needed. Moreover, the DNA remains tightly coupled to the silica coated paramagnetic resin for the entire process until the elution step. A short pre-extraction incubation step is necessary prior to loading samples onto the robot and it is at this step that most modifications are made to accommodate the different sample types and substrates commonly encountered with forensic evidentiary samples. Sexual assault (mixed stain) samples, cigarette butts, blood stains, buccal swabs, and various tissue samples were successfully extracted with the BioMek 2000 Laboratory Automation Workstation and the DNA IQ System, with no evidence of contamination throughout the extensive validation studies reported here.
2022-12-15T08:11:45.656Z
83,264,183
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1248/CPB.39.1672", "MAG": "1531124321", "PubMedCentral": null }, "license": null, "status": null, "url": null }
The effect of temperature on the Pictet-Spengler reaction of Nb-hydroxytryptamines (1) and cysteinals (2) has been examined. The optically active nitrones (3), obtained from 1 and 2, gave the corresponding Nb-hydroxy-β-carbolines (4α and 4β) exclusively at -78°C in the presence of an excess of trifluoroacetic acid. The mechanism is discussed in relation to the stereochemistry.
2022-12-19T00:32:11.711Z
46,206,335
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1111/j.1365-2923.2007.02900.x", "MAG": "1704393628", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Objectives  To ascertain the expectations of Nepalese patients regarding aspects of doctor–patient communication and to review a model of patient‐centred care for its appropriateness to Nepalese medical communication training.
2022-12-22T17:17:58.904Z
32,251,341
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1043/0003-3219(2005)075<0192:OOLCOL>2.0.CO;2", "MAG": "1861285535", "PubMedCentral": null }, "license": null, "status": null, "url": null }
This study was undertaken to identify the variations in the physiologic ossification of human laryngeal cartilages by evaluating the lateral cephalometric radiographs of healthy males and females referred to our facility. Lateral cephalometric radiographs of 359 patients (141 male and 218 female; ages 10 to 59 years) referred from various specialty clinics between April 1998 and March 2000 were used. Frequencies and confidence intervals were obtained and tabulated for both thyroid and cricoid ossifications as seen on these cephalometric radiographs. The interobserver agreement was strong for both thyroid (kappa = .986) and cricoid (kappa = .982) observations. Overall, thyroid cartilage was more frequently ossified compared with cricoid. Various degrees of thyroid and cricoid cartilage ossification were found in 186 patients (120 female and 66 male) in the third decade and beyond. Among 173 patients in the first 2 decades (98 females and 75 male), evidence of thyroid ossification was found in 2 male patients aged 14 and 18, and ossification was detected in the cricoid cartilage in 12 patients. There was a preponderance of laryngeal cartilage ossification in men compared with women. Radiographically detectable laryngeal ossification increased with age starting in the third decade. There is a general trend of increase in the ossification of laryngeal cartilages as the age advanced.
2022-12-29T16:37:58.248Z
59,614,333
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1155/2019/7683648", "MAG": "2910039651", "PubMedCentral": "6348850" }, "license": "CCBY", "status": "GOLD", "url": "https://doi.org/10.1155/2019/7683648" }
Objective To investigate CT morphologic and densitometric features and 18-FDG PET findings of surgically excised lung adenocarcinomas “mixed subtype” with predominant lepidic component, appearing as solid solitary pulmonary nodules (SPNs) on CT scan. Materials and Methods Approval for this study was given from each local institutional review board according to its retrospective nature. Nodules pathologically classified as lung adenocarcinoma mixed subtype with bronchioloalveolar otherwise lepidic predominant component, in three different Italian institutions (Napoli; Varese; Parma), were retrospectively selected. Results 22 patients were identified. The number of SPNs with smooth margins was significantly lower with respect to the number of SPNs with spiculated margins (p: 0.033), radiating spiculations (p: 0.019), and notch sign (p: 0.011). Mean contrast enhancement (CE) was 53.34 HU (min 5.5 HU, max 112 HU); considering 15 HU as cut-off value, CE was positive in 20/22 cases. No significant correlation was found between size and CE. Mean SUVmax was 2.21, ranging from 0.2 up to 7.5 units; considering 2.5 units as cut-off, SUVmax was positive in 7/22 cases. The number of SPNs with positive CE was significantly higher than the number of SPNs with positive SUVmax (p: 0.0005). Conclusion CT generally helps in identifying solid SPN suspicious for malignancy but 18-FDG PET may result in false-negative evaluation; when 18-FDG PET findings of a solid SPN are negative even though CT morphology and CE suggest malignancy, radiologist should consider that lepidic component may be present inside the invasive tumor, despite the absence of ground glass.
2023-01-01T17:14:52.731Z
139,416,515
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1117/12.2314081", "MAG": "2815469241", "PubMedCentral": null }, "license": null, "status": "GREEN", "url": "https://repository.arizona.edu/bitstream/10150/632248/1/107063Q.pdf" }
Application of CMOS image sensors with non-destructive readout capability have several advantages over current CCD sensors in detecting Near-Earth Objects (NEOs). They include detection of temporal changes, cosmic ray rejection, no charge blooming, expanded dynamic range, and lower dark current. Since wide field survey usually requires large mosaics, a “rolling shutter” operation simplifies the challenge of large mechanical shutters. Being able to readout parts of the field in destructive mode offers the possibility of providing guiding feedback to the telescope during exposure. We have carried out preliminary testing of a prototype CMOS camera built by Spectral Instruments Inc. on a one-meter telescope on Mt. Lemmon, Arizona as applied to rapidly moving NEOs. We have also demonstrated “post facto” guiding on a known NEO that significantly improves the signal to noise.
2022-02-09T09:36:51.021Z
95,298,437
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1246/BCSJ.56.1863", "MAG": "2018376782", "PubMedCentral": null }, "license": null, "status": null, "url": null }
The catalysis of the oxidation of Fe2+ aquaion by [Mo(CN)8]3− ion, which is formed on an electrode surface, and that of the reduction of Fe3+ aqua ion by [Mo(CN)8]4− ion were examined by means of hydrodynamic voltammetry at a rotating disk pyrolytic graphite electrode The rate constants of the electron transfer cross-reaction of the Fe2+/[Mo(CN)8]3− and Fe3+/[Mo(CN)8]4− systems were estimated to be (7.0±0.5)×106 and (6.6±0.5)×106 cm3 mol−1 s−1, respectively.
2022-07-29T05:26:40.838Z
82,132,775
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.17660/ACTAHORTIC.2009.842.71", "MAG": "308548768", "PubMedCentral": null }, "license": null, "status": null, "url": null }
There is increasing interest in organic production in Latvia during the last years. To establish strawberry cultivars more suitable for organic growing in Latvian agro-ecological conditions an evaluation was started at the Pure Horticultural Research Station in 2003. Ten widely grown strawberry cultivars were included in the preliminary investigation that was conducted on a conventional field, but without using chemical plant protection products and fertilizers. In 2005, 16 cultivars were planted on certified organic field, where only in organic farming permitted plant protection and nutrition products were used. The following traits were evaluated: winter hardiness, yield, quality, fruit size, susceptibility to the most widespread pests and diseases. In the preliminary investigation the best results were showed by the cultivars 'Induka', 'Jonsok', 'Dukat' and 'Korona'. In the second trial, the highest marketable yield was obtained from the cultivars 'Polka', 'Bounty', 'Pandora' and 'Senga Sengana'. The cultivar 'Honeoye' showed very good fruit quality.
2022-08-30T18:26:24.240Z
129,855,359
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1061/(ASCE)HY.1943-7900.0000193", "MAG": "2056314533", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Regulations require U.K. water companies to reduce the number of properties at risk of sewer flooding. One of the potential causes of sewer flooding is the presence of persistent sediment deposits in sewers, such deposits are a common problem in many combined sewers. Although the regulations are risk based, there is a gap in the current knowledge on how the risk assessment is affected by the uncertainty in sewer sediment transport prediction. This paper describes the development of a methodology for estimating uncertainty in sewer sediment deposit depth predictions using existing empirically calibrated sediment load equations and Monte Carlo simulations combined with a response database. This methodology has been used to estimate the range of uncertainty of in-pipe deposit build-up predictions for a U.K. combined sewer system that suffered persistent deposition problems.
2022-09-09T13:00:38.307Z
46,925,725
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.3233/978-1-61499-872-3-32", "MAG": "2886589696", "PubMedCentral": null }, "license": null, "status": null, "url": null }
A mobile application to support individuals receiving treatment for active tuberculosis (TB) by self-administration is being developed with TB experts and patients in active TB treatment using agile development methods to meet the needs of endusers.
2022-09-02T15:23:37.218Z
10,493,835
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1001/JAMA.1984.03340430036025", "MAG": "1985139132", "PubMedCentral": null }, "license": null, "status": null, "url": null }
We evaluated a totally implanted system consisting of a subcutaneous injection port connected to a silicone elastomer central venous catheter for vascular access, including blood drawing, in 35 patients with cancer. All patients lacked peripheral venous access sites and were undergoing aggressive chemotherapy programs. The cumulative duration of successful access exceeded 2,900 days (for individual patients: range, five to 203 days; median, 61 days). In no instance were infusions or injections unsuccessful. Blood-sampling attempts were successful 90% of the time. The system did not require flushing between uses, being filled with heparinized saline after each entry. There were no instances of irreversible catheter occlusion or shear and no system-related infections. Thus, this device appears to have advantages over other central venous catheters in terms of patient acceptance and lack of maintenance between uses.
2022-12-13T21:04:04.164Z
3,109,267
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1111/j.1365-4362.1994.tb02922.x", "MAG": "1977753825", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Background. Toxic epidermal necrolysis is a distinctive disorder that is readily identified clinically and histologically in advanced cases. Early on, however, toxic epidermal necrolysis may be difficult to identify. Some consider fixed drug eruption a limited form of toxic epidermal necrolysis.
2022-12-19T05:34:16.678Z
147,385,623
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1628/004435404774538525", "MAG": "2327111501", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Kierkegaard has been sensitive as one of the first for the question of the chances of Christianity in times of modern mass media. The essay involves his theses in a conversation with Hans Joachim Iwand and Niklas Luhmann.What means a Christian truth-understanding in our medial constructed reality?
2022-02-09T05:25:35.893Z
198,104,773
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.31811/ojomus.504529", "MAG": "2906797121", "PubMedCentral": null }, "license": "CCBYNCND", "status": "GOLD", "url": "https://dergipark.org.tr/en/download/article-file/610718" }
Turk Muzigi, yuzyillar boyunca usta-cirak iliskisi ve hafizaya dayali mesk sistemi ile devamliligini surdurmustur. Ancak icracilar ve besteciler, muzigi hafizalarina kaydetmeyi tercih etseler de, Turk Muzigi’nin tarihsel seruvenine baktigimizda eserlerin aktarimlarini ve unutulmamalarini saglayan,  onlari gelecege tasiyan onemli araclardan biri olan muzik yazilari uzerine calismalar yapildigi da ifade edilebilir. Bu muzik yazilarinin icerisinde en yaygin sekilde kullanilaninin ise 19. yuzyilda gelistirilen Hamparsum muzik yazisi oldugu soylenebilir. Hem Turk Muzigi cevrelerinde hem de Ermeni kiliselerinde kullanilmis olan Hamparsum muzik yazisi araciligi ile pek cok eser aktarilabilmistir. Istanbul Arkeoloji Muzeleri Kutuphanesi’nde bulunan 1537 no’lu defterde de Hamparsum muzik yazisi ile 39 adet pesrev, 12 adet saz semaisi ve 1 adet sarki formunda eser kayit altina alinmistir. Bu defterin tanitilmasi ve iceriginin gunumuz notasina cevrilmesi, eserlerin aktarimi acisindan onemli oldugu gibi, yazildigi donemin icra ozelliklerini yansitmasi ve eserlerin zaman icindeki degisimini gostermesi acisindan da cok buyuk bir onem tasimaktadir. Bu calismada, Istanbul Arkeoloji Muzeleri Kutuphanesi’nde bulunan ve Hamparsum muzik yazisi ile yazilmis 1537 no’lu defterin ve iceriginin degerlendirmesi yapilmis, defterin aidiyeti hakkinda degerlendirmelerde bulunulmus, defterdeki muzik yazisi ve muzik yazisinin uygulanisi ile ilgili bulgular aktarilmistir.
2022-06-04T14:21:47.560Z
146,938,686
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1093/SF/77.3.1199", "MAG": "2324160458", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Several authors discuss measurement problems with some of the variables, and point out areas needing future research. Stewart's editorial leadership and skill are impressive. His introduction is not only a summary of the chapters, but also a synthesis and analysis of the issues and their possible solutions. He closely examines each contribution and its links with the other studies in the volume. I would have liked, however, more discussion of the characteristics of a post-industrial economy, the relationships that exist between the findings and the stage of post-industrialism in which they occur, and the accumulated effects of these experiences on African American labor. A chronological structure might help readers understand post-industrialism better. A future companion volume analyzing 1990s data could provide a picture of what has changed and what has not, and might enable us to compare the post-industrial experiences in the 1970s and 1980s with those in the 1990s. This might aid our efforts to understand what the postindustrial experience is and has been, and its various stages. Stewart's opening article, "Toward Broader Involvement of Black Economists in Discussions of Race and Public Policy: A Plea for a Reconceptualization of Race and Power in Economic Theory," examines a disturbing theoretical limitation in much of the literature on racial discrimination. Most economic models do not "address adequately issues of group identification and its effects on economic behavior" and, in fact, devalue the importance of group identification to economic affairs (pp. 16, 17). Stewart's theoretical critique reminds us that if we want good results we must specify our models accurately, and be willing to create alternative paradigms. One of the strengths of all the contributions is that the authors take pains to specify their models carefully, which often means revising approaches taken by previous research and tackling controversial issues. These articles move us forward, but only so far-just hinting at how much farther we could go. They are weak, for example, when it comes to questioning mainstream economic theoretical tenets, challenging existing economic structures and systems, and using alternative paradigms to explore solutions. They tend to rely on increased enforcement of traditional public policies. While many of the authors identify constraints placed on African Americans by labor market structures (see Gyimah-Brempong and Fichtenbaum, for example), their solutions focus mostly on increased access and opportunity, rather than on changes to those structures. Although the ultimate message that economic racism persists is discouraging, we can take heart that fine scholars are committed to advancing the scholarship in this area, redefining our research agendas, and redesigning our policy solutions in ways that reflect needs across race, ethnicity, gender, and region. There is not much left to prove. Using this important research, let us move forward with productive and creative ways to achieve comprehensive and sustainable economic justice.
2022-01-27T02:41:12.703Z
117,120,342
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.5103/KJSB.2003.13.2.013", "MAG": "261629755", "PubMedCentral": null }, "license": null, "status": null, "url": null }
The purpose of this study was to analyze the kinematic characteristics of Ice hockey slap shot. The subjects of this study were four professional ice hockey players. The reflective markers were attached on the anatomical boundary line of body and the subjects were asked to perform the shot. Ariel Performance Analysis System was used to capture and digitize the shooting image, the data were analyzed by LabView 6i. The results were as fellows. 1. The period of the back swing phase was , the down swing phase was and the total swing time was 2. The maximum linear velocity of the stick blade for x direction was shown after 7% of impact, for y, z direction were shown before 2%, 8% of Impact. 3. The maximum velocity of each segment for the left arm was in the upper arm, in the forearm, in the hand. 4. The maximum velocity of each segment for the right arm was in the upper arm, in the forearm, in the hand. 5. The angle of left elbow was generally flexed from the ready stance to the impact and was the moment of Impact. 6. The angle of the left shoulder was increased ut the down swing phase and was on the moment of impact. 7. The angle of the right shoulder was decreased in the down swing phase and increased before the impact. and the angle was on the moment of impact.
2022-09-07T14:38:23.979Z
140,646,234
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1117/12.541996", "MAG": "2003324409", "PubMedCentral": null }, "license": null, "status": null, "url": null }
A simple and practical approach to calibrate extrinsic parameters of camera mounted in intelligent vehicle is presented. Because mapping of three parallel lines in the world into image plane have same vanishing point and different slope, according to perspective projection principle, an inherent relationship exists among camera extrinsic parameters and vanishing point and slope. Such the analytic expression of camera extrinsic parameters can be built by mathematical derivation, without iterative and optimizing calculation. After positioning intersection points and slopes of imaging lines manually or automatically, extrinsic parameters can be calculated directly. The experimental results show that the method can be applied in various circumstances.
2022-09-14T08:09:36.592Z
84,999,354
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.5536/KJPS.2012.39.2.157", "MAG": "2061838978", "PubMedCentral": null }, "license": null, "status": null, "url": null }
The objective of this study was to evaluate the effects of feeding dried Thymus vulgaris powder (TVP) on the layer performance, egg quality and egg yolk fatty acid composition. Two hundred eighty eight, 35 weeks old Brown nicks were allocated in the cage for five TVP (0, 0.25, 0.5, 1.0 and 2.0%) diets with four replicates in each treatment. Each basal diet contained 16.0% CP and 2,800 kcal/kg ME and supplied to layers for 8 weeks. Egg production and egg weight were not statistically different but numerically increased in birds fed 2.0% TVP than other treatments. Egg mass was not consistent depending on the TVP addition levels in diets. Feed intake was significantly lower in TVP addition treatments than the control (p
2022-09-16T02:54:02.693Z
34,044,288
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1136/jcp.46.11.1042", "MAG": "2080362922", "PubMedCentral": null }, "license": null, "status": "BRONZE", "url": "https://jcp.bmj.com/content/46/11/1042.full.pdf" }
AIMS--To make a preliminary assessment of the clinical relevance of serum vitronectin concentrations in various disease groups, using a recently available commercial radial immunodiffusion kit. METHODS--Serum vitronectin concentrations were measured in 80 control subjects and 144 patients with various diseases. The following characteristics were used to evaluate the test procedures: linearity of method, inter- and intrabatch precision, effect of storage, temperature and in vitro activation of the classical and alternative complement pathways on vitronectin concentrations. RESULTS--Significantly reduced serum vitronectin concentrations were found in patients with liver disease, renal disease, and systemic lupus erythematosus (SLE) (normal C3 and C4 concentrations, when compared with normal subjects. This particular method was suitable for measuring vitronectin concentrations in serum samples provided they were stored at -20 degrees C. CONCLUSIONS--The clinical value of measuring serum vitronectin seems to be limited, but a larger study may be justified to ascertain the clinical importance of reduced serum vitronectin concentrations in liver diseases, and the possible role of vitronectin in other disease processes.
2022-12-16T21:50:38.592Z
121,371,366
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.4153/CJM-2005-053-9", "MAG": "2050394719", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Abstract In 1999 V. Arnol’d introduced the local contact algebra: studying the problem of classification of singular curves in a contact space, he showed the existence of the ghost of the contact structure (invariants which are not related to the induced structure on the curve). Our main result implies that the only reason for existence of the local contact algebra and the ghost is the difference between the geometric and (defined in this paper) algebraic restriction of a 1-form to a singular submanifold. We prove that a germ of any subset $N$ of a contact manifold is well defined, up to contactomorphisms, by the algebraic restriction to $N$ of the contact structure. This is a generalization of the Darboux-Givental’ theorem for smooth submanifolds of a contact manifold. Studying the difference between the geometric and the algebraic restrictions gives a powerful tool for classification of stratified submanifolds of a contact manifold. This is illustrated by complete solution of three classification problems, including a simple explanation of V. Arnold's results and further classification results for singular curves in a contact space. We also prove several results on the external geometry of a singular submanifold $N$ in terms of the algebraic restriction of the contact structure to $N$ . In particular, the algebraic restriction is zero if and only if $N$ is contained in a smooth Legendrian submanifold of $M$ .
2022-12-21T09:57:31.355Z
21,580,801
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1111/j.1556-4029.2007.00458.x", "MAG": "2069205668", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Abstract:  Anthropometry can be used in certain circumstances to facilitate comparison of a photograph of a suspect with that of the potential offender from surveillance footage. Experimental research was conducted to determine whether anthropometry has a place in forensic practice in confirming the identity of a suspect from a surveillance video. We examined an existing database of photographic lineups, where one video image was compared against 10 photographs, which has previously been used in psychological research. Target (1) and test (10) photos were of high quality, although taken with a different camera. The anthropometric landmarks of right and left ectocanthions, nasion, and stomion were chosen, and proportions and angle values between these landmarks were measured to compare target with test photos. Results indicate that these measurements failed to accurately identify targets. There was also no indication that any of the landmarks made a better comparison than another. It was concluded that, for these landmarks, this method does not generate the consistent results necessary for use as evidence in a court of law.
2022-12-26T16:27:11.720Z
57,735,276
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.12968/eyed.2017.19.1.22", "MAG": "2605346720", "PubMedCentral": null }, "license": null, "status": null, "url": null }
The sector had waited a long time for the publication of the workforce strategy. It was published, on March 3, along with related documents, including an updated version of the Early Years Foundation Stage.
2022-02-11T17:47:46.163Z
23,207,836
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1111/coa.12609", "MAG": "2211727163", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Epistaxis is a common indication for admission under ENT care. Such patients usually have nasal packing for a short period, and social circumstances or medical comorbidities may prevent discharge home with packs in situ. With bed pressures and an elderly epistaxis population, these admissions are far from ideal but are unavoidable in those with significant bleeds. When packs are removed, for those who bleed there is strong evidence for the timely use of endoscopic ligation of the spheno-palatine artery. This treatment is favoured by patients, is cost-effective and has minimal re-admissions for rebleeds. However, for those who do not bleed on pack removal, the management options to reduce potential rebleeds and re-admissions are less clear. They may include nasal lubricants, for example Vaseline, Nasogel, Naseptin or silver nitrate cautery – all of which for anterior epistaxis have little significant evidence confirming their efficacy, least of all in previously packed patients. In terms of medical therapy, tranexamic acid is licensed in the UK for epistaxis and is an antifibrinolytic agent designed to reduce clotting time. The data are largely associated with patients with hereditary haemorrhagic telangiectasia (HHT), where tranexamic acid has been shown to significantly reduce the number of epistaxis episodes in addition to the bleed time. In uncomplicated epistaxis, there is emerging evidence that topical tranexamic acid is more effective than anterior nasal packing. Accurate figures regarding epistaxis re-admissions are absent from the literature. Re-attendance to emergency departments for epistaxis has been quoted at 17%, and actual re-admission rate in one small series was 10%. The aim was therefore to initially quantify the extent of epistaxis re-admissions to a district general hospital over a 5year period and to examine whether there were any differences between re-admitted and non-re-admitted patients, with regard to anticoagulation or antiplatelet use and their indications. Our further aim was to determine which patients could have been eligible for tranexamic acid upon discharge, taking into account any contraindications they may have had to the drug.
2022-02-12T19:25:55.263Z
221,634,901
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1046/j.1423-0410.1998.7410036.x", "MAG": "2064163802", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Background and objectives: The very sensitive solid‐phase antiglobulin test is used widely in blood group serology. However, a disadvantage of the test is the sedimentation variability of indicator cells during centrifugation, which causes errors in the photometric evaluation. Materials and methods: To solve this problem a technique was developed which depends on the ‘length measurement of the absorption curve’ of the sedimented indicator cells. Results: 9,075 sera were tested for the presence of alloantibodies on the basis of the visual type of measurement and the newly developed technique. The agreement between the two evaluation systems was 99.94%. No false‐negative results were observed. Conclusion: The new method allows the complete automation of the solid‐phase antiglobulin test, enabling the analysis and evaluation of the solid‐phase microtiter plate assay to be more discriminating and safe.
2022-06-28T01:41:27.053Z
225,946,317
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.5007/2175-7984.2020v19n44p204", "MAG": "3033839349", "PubMedCentral": null }, "license": "CCBY", "status": "GOLD", "url": "https://periodicos.ufsc.br/index.php/politica/article/download/2175-7984.2020v19n44p204/43483" }
Authors such as Pocock, Skinner and Pettit have revalued republicanism as a fundamental political tradition in the constitution of the modern world in contrast to the hegemony of the liberal tradition. This paper aims to analyze what has been characterized as a most problematic and challenging relationship for Republicans: the relationship between republicanism and Christianity. Taking as its thread the analysis of the debate between Black and Nederman, we argue that the difficulty in analyzing the relationship between republicanism and Christianity derives from the very difficulties of the neo-republican project in delimiting republicanism as a specific political tradition. Overcoming such dilemmas would involve a better qualification of the republican tradition including the themes of the political community as a "universal community", a non-instrumental conception of public life, and the recognition that the conception of liberty as non-domination implies that republican institutions promote certain values.
2022-12-09T04:21:50.953Z
34,472,005
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1111/J.1476-5381.1955.TB00886.X", "MAG": "2083773215", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Recently it was found (Feldberg and Sherwood, 1954b) that the anticholinesterases dyflos (DFP) and eserine, when given to cats by the intraventricular route, produce a condition with many of the features of "catatonia." Experimental "catatonia " or " catalepsy " in animals is usually associated with the drug bulbocapnine and was first obtained with this substance by Peters (1904). There are numerous later publications (for reference see Ingram and Ranson, 1934; de Jong, 1945) on the action of bulbocapnine in producing this condition when given subcutaneously, but relatively large doses, between 20 and 30 mg./ kg., are required to bring about the effect when administered in this way. In the present experiments it is shown that bulbocapnine is active in much smaller doses by the intraventricular route.
2022-12-21T02:25:05.216Z
170,164,096
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1177/002096435601000133", "MAG": "1965963919", "PubMedCentral": null }, "license": null, "status": null, "url": null }
of the non-Christian world? Dr. Latourette's answer to this question, given first as a series of popular lectures in various universities abroad, is found in this slender little volume. In spite of defeats and dangers which we cannot overlook, Dr. Latourette concludes, "Protestantism continues to be vital, to grow, and by its fruits to show that through it the Gospel still finds channels in which it flows, transformingly, into the world." The chief value of the book is to be found in the broad survey which it gives of worldwide Christianity in the present day.
2022-02-08T17:30:12.240Z
87,907,659
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.7213/REB.V32I76/81.22871", "MAG": "2263234326", "PubMedCentral": null }, "license": null, "status": null, "url": null }
O presente estudo teve como objetivo investigar o grau de conservacao entre aminoacidos presentes na proteina de choque termico HSP70 em especies animais, empregando ferramentas de alinhamentos multiplos. Tais analises comparativas foram realizadas a partir do algoritmo ExPASy Proteomics Server, capaz de organizar e ordenar dados biologicos, inferindo informacoes cruciais acerca da estrutura e funcao de biomoleculas. A analise do segmento peptidico HSP701A, contendo 644 aminoacidos, demonstrou maxima conservacao e identidade entre os residuos da proteina HSP70, correspondendo a 60% dos residuos totais. Em adicao, o alinhamento multiplo entre os aminoacidos da HSP70 nas especies selecionadas demonstrou maior similaridade entre as sequencias da HSP70 bovina e humana. Os resultados gerados a partir das sequencias de aminoacidos da proteina HSP70 em distintas especies sugerem um elevado grau de similaridade entre animais geneticamente divergentes. O alto grau de similaridade e identidade observado em tais analises comparativas reforca a crucial participacao da proteina de estresse HSP70 nos mecanismos celulares universais de reparo de peptideos recem sintetizados e nas respostas celulares ao estresse.
2022-02-10T21:02:14.495Z
60,653,978
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1109/IMTC.1995.515402", "MAG": "1552854068", "PubMedCentral": null }, "license": null, "status": null, "url": null }
With the advancement of optical technology, it has become possible to implement various logical functions using all-optical/electrooptic devices. Examples of these promising devices that can achieve this objective is the Fabry-Perot interference filter and the SEED. Using these highly functional, bistable and fast devices, all-optical switches, logic gates and flip-flops, can be implemented. In this paper, the use of optical logic gates as a building block in high speed, high data rate, signal processing and data acquisition applications, will be investigated. The design and implementation of an optical wavelength division multiplexer are proposed. This design has many novel features that makes it compact and adaptable to large scale architectures requiring frequencies in the GHz and THz range
2022-02-11T15:48:23.498Z
143,285,740
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.7202/001407AR", "MAG": "1777571743", "PubMedCentral": null }, "license": null, "status": null, "url": null }
En quoi la sociologie des mouvements sociaux permet-elle d'analyser le mouvement des femmes? A partir d'une reflexion sur les problematiques developpees par Manuel Castells et surtout Alain Touraine, cet article tente de cerner a la fois la notion de mouvement social et de l'appliquer a la realite du mouvement feministe. Mais l'interrogation s'elargit au rapport qu'entretient la sociologie, et plus particulierement la sociologie des mouvements sociaux, avec les luttes sociales. La sociologie se nourrit-elle des luttes sociales ou permet-elle d'en approfondir le contenu ? Peut-on codifier les pratiques sociales sans les occulter, du moins en partie ?
2022-06-07T04:06:33.679Z
20,787,179
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1536/IHJ.21.485", "MAG": "1988384050", "PubMedCentral": null }, "license": null, "status": null, "url": null }
The effects of verapamil, a slow channel blocker and a potent antiarrhythmic drug, on retrograde V-A conduction were investigated following diagnostic cardiac catheterization in 12 children premedicated with lytic cocktail. Surface EKG, intra-atrial and His bundle electrograms, as well as right ventricular pacing with use of extra stimulus technique were obtained before and after a single intravenous dose of verapamil (0.15 mg/Kg, max 5 mg). Verapamil prolonged the AH interval in 9/12 and abolished or prolonged the retrograde V-A conduction whenever present (abolition in 5/12 and prolongation in 1/12). The duration of retrograde V-A conduction exceeded the antegrade conduction time in all. It is concluded that verapamil abolishes retrograde V-A conduction whenever present and this phenomenon may further explain the antiarrhythmic effects of the drug on retrograde conduction dependent (reentrant) arrhythmias.
2022-06-23T02:27:07.259Z
250,915,576
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1070/RM1995v050n04ABEH002588", "MAG": null, "PubMedCentral": null }, "license": null, "status": null, "url": null }
The known general formulae for finding the volume of a polyhedron require the knowledge of information on the position of the polyhedron in space. Nevertheless, in all known examples of bendable polyhedra it turns out that the volume remains constant in the process of bending. In connection with this, Connelly and Sullivan have conjectured that this fact is universal. One of the possible approaches to the establishment of this conjecture has been suggested by I. Kh. Sabitov: it is sufficient to prove that for given lengths of the edges there are only finitely many possible values for the volume of a polyhedron. For this, in turn, it is sufficient to show that the volume of a polyhedron is the root of a polynomial with coefficients depending on the lengths of the edges. In this paper this method is realized for a pendant. volume non-trivially bendable pendant The content of our result foundation of a method enabling us of pendants, isometric themsleves, before them space, knowing only the lengths of the edges.
2022-07-31T09:17:56.493Z
197,087,937
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1055/S-2008-1078264", "MAG": "2951945656", "PubMedCentral": null }, "license": null, "status": null, "url": null }
An efficient, synthetically useful catalytic cunjugate addition of cyanide to enones was developed using cooperative catalysis of Ni(0) and Gd(OTf) 3 . The co-catalyst, Gd(OTf) 3 , dramatically accelerated the reaction. The substrate scope is broad, including cyclic, linear, branched, and aromatic enones. Synthetic efficiency of the key conversion in our Tamiflu synthesis, conjugate cyanation of an enone, was significantly improved by using this new method. Gadolinium triflate is supposed to facilitate the oxidative addition of Ni(0) to enones, which constitutes a key step in the catalytic cycle.
2022-07-31T06:23:45.807Z
253,962,517
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1079/cabicompendium.43288", "MAG": null, "PubMedCentral": null }, "license": null, "status": null, "url": null }
This datasheet on Populus 'Pannonia' covers Identity.
2022-11-26T18:46:04.131Z
38,836,615
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1002/1097-0142(197006)25:6<1286::AID-CNCR2820250606>3.0.CO;2-U", "MAG": "2048565450", "PubMedCentral": null }, "license": null, "status": null, "url": null }
The clinical and histopathologic features of 2 examples of isolated lymphoid tumors (so‐called nodal hyperplasia, lymphoid, or angiomatous lymphoid hamartoma) occurring in an 11‐year‐old girl and a 42‐year‐old man are presented. This designation for this lesion appears at present more appropriate than those expressed parenthetically since considerations suggest that it may represent a heterogeneous group of neoplastic and nonneoplastic lesions comprised of prototype and transitional forms of lymphocytes, reticulum cells, and plasma cells. Occasional cells morphologically indistinguishable from Sternberg‐Reed cells were encountered in the most recent of 4 biopsies obtained over a 6‐year period in the young girl and in only several of many sections prepared from the tumor removed from the adult patient of this report. Other features of Hodgkin's disease or other recognized malignant lymphomas were lacking, and the clinical course in both has been otherwise uneventful for 6 and 1 years, respectively. Ultrastructural study of the lesion from the adult revealed features in some reticulum cells similar to those observed in cells comprising overt reticulum cell sarcoma. Virus‐like particles resembling those depicted as occurring in some murine as well as human leukemias and malignant lymphomas were also noted. Similar particles were also observed in cells comprising “primary” growths and metastases noted following heterotransplantation of aliquots of this lesion to the cheek pouch of unconditioned hamsters. This information strongly suggests that some of these lesions may possess a malignant biological potential, being in this regard analogous to the situation experienced with the nodal lesion apparently induced by antiepileptic drugs.
2022-12-18T21:31:29.897Z
30,315,278
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1097/PAS.0b013e3181788533", "MAG": "2019766825", "PubMedCentral": null }, "license": null, "status": null, "url": null }
The clinicopathologic and immunohistochemical features of 69 pediatric examples of infantile digital fibroma/fibromatosis (IDF) were analyzed. Thirty males, 26 females, and 1 child (sex unstated) ranging from newborn to 120 months of age (median, 12 mo) manifested 74 lesions (5 identified in follow-up) involving the toe or finger (n=71) and the hand or foot (n=3). Tumors ranged in size from 3 to 35 (median, 10) mm. All but 4 study members presented with a solitary lesion. Metachronous IDFs developed in 7 patients within 17 to 82 months. Microscopically, a cytologically bland, fibroproliferative lesion was observed forming a dome-shaped/polypoid nodule directly beneath the epidermis and invading dermal adnexa. Mitotic figures per 20 high-powered fields ranged from 0 to 7 (median, 1). Paranuclear cytoplasmic inclusions were identified in 57 tumors. Tumor cells immunohistochemically expressed calponin (11 of 11 tumors), desmin (9/9), α-smooth muscle actin (11/11), CD99 (11/11), CD117 (6/8), heavy caldesmon (2/11 and scattered cytoplasmic inclusions in 4 tumors), CD10 (1/9), nuclear β-catenin (2/11), and CD34 (1/11), but not muscle actin (HUC1-1), keratins, estrogen/progesterone receptor proteins, or activated caspase-3. Twenty-eight of 38 patients (74%) experienced recurrent/persistent disease (single in 22; multiple in 6) (median, 4 mo after surgery). One recurrent tumor spontaneously regressed and the size of another remained unchanged for almost 17 years before reexcision. All 23 patients with >5 years follow-up are currently disease free (median disease-free interval, 23 y). Minor postoperative functional/cosmetic complaints were reported in 47%. No patient with adequate clinical data developed the digitocutaneous dysplasia syndrome or a conventional fibromatosis, or relayed a family history of IDF/conventional fibromatosis. Our results indicate that IDF is a unique myofibroblastic process separable from conventional fibromatoses and from histologic mimics. Conservative excision or observation after biopsy (with additional surgery employed as necessary) are recommended treatment options.
2022-12-20T13:32:27.751Z
243,318,070
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.51698/tripodos.2020.49p129-149", "MAG": null, "PubMedCentral": null }, "license": "CCBYNCSA", "status": "GOLD", "url": "http://www.tripodos.com/index.php/Facultat_Comunicacio_Blanquerna/article/download/708/863" }
This article examines populist leaders’ politicisation of food in their social media performances. More precisely, it analyses Matteo Salvini’s Instagram posts during the 2019 European elections, and the way food is mobilized for populist and nationalist purposes. The main argument is that food serves as a cultural trope that confers identity, reinforcing social divisions and the terms of national and class belonging. Drawing on Bourdieu’s (1984) social critique of taste, political leaders have traditionally placed themselves on the side of a distant gastronomic culture; that of a high-end elite. However, populist leaders perform a twofold role, attempting to present themselves as part of the common people and distancing themselves from the traditional elite. This change in social positioning is reflected in their social media accounts, often posting “authentic” glimpses of their cultural practices, such as cooking and eating. Methodologically, this paper uses a mixed-methods concurrent design, combining digital ethnography and visual rhetoric analysis for examining both the discursive and the aesthetic clues that construct Salvini’s social positioning towards taste. Through food, being Italian becomes a matter of constructing Italian authenticity against the national intellectual and political elite, but also against the European value-building project.
2022-07-10T04:12:11.764Z
34,712,248
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1111/j.1526-4610.2009.01411.x", "MAG": "1971261808", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Objective.— To compare patient recall of migraine headache frequency and severity over 4 weeks prior to a return visit as reported in an interval questionnaire vs a daily diary.
2022-10-05T14:59:53.268Z
59,436,290
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1093/BIOMET/ASU013", "MAG": "1970915906", "PubMedCentral": null }, "license": null, "status": null, "url": null }
A population can be entered at a known sequence of discrete times; it is sampled cross-sectionally, and the sojourn times of individuals in the sample are observed. It is well known that cross-sectioning leads to length-bias, but less well known and often ignored that it may also result in dependence among the observations. We show that observed sojourn times are independent only under a multinomial entrance process. We study asymptotic properties of parametric and nonparametric estimators of the sojourn time distribution using the product of marginals in spite of dependence, and provide conditions under which this approach results in proper or improper and wrong inference. We apply the proposed methods to data on hospitalization time after bowel and hernia surgeries collected by a cross-sectional design.
2022-12-12T12:35:25.429Z
2,214,831
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1523/JNEUROSCI.5245-07.2008", "MAG": "2082905363", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Cyclin-dependent kinase 5 (cdk5) and glycogen synthase kinase 3β (GSK3β) have been implicated in pathogenic processes associated with Alzheimer's disease because both kinases regulate tau hyperphosphorylation and enhance amyloid precursor protein (APP) processing leading to an increase in amyloid β (Aβ) production. Here we show that young p25 overexpressing mice have enhanced cdk5 activity but reduced GSK3β activity attributable to phosphorylation at the inhibitory GSK3β–serine 9 (GSK3β–S9) site. Phosphorylation at this site was mediated by enhanced activity of the neuregulin receptor complex, ErbB, and activation of the downstream phosphatidylinositol 3 kinase/Akt pathway. Young p25 mice had elevated Aβ peptide levels, but phospho-tau levels were decreased overall. Thus, cdk5 appears to play a dominant role in the regulation of amyloidogenic APP processing, whereas GSK3β plays a dominant role in overall tau phosphorylation. In older mice, GSK3β inhibitory phosphorylation at S9 was reduced relative to young mice. Aβ peptide levels were still elevated but phospho-tau levels were either unchanged or showed a trend to increase, suggesting that GSK3β activity increases with aging. Inhibition of cdk5 by a specific inhibitor reduced cdk5 activity in p25 mice, leading to reduced Aβ production in both young and old mice. However, in young mice, cdk5 inhibition reversed GSK3β inhibition, leading to an increase in overall tau phosphorylation. When cdk5 inhibitor was administered to very old, nontransgenic mice, inhibition of cdk5 reduced Aβ levels, and phospho-tau levels showed a trend to increase. Thus, cdk5 inhibitors may not be effective in targeting tau phosphorylation in the elderly.
2022-12-20T04:56:41.033Z
103,057,488
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1039/c7ra12613a", "MAG": "2781806876", "PubMedCentral": "9076992" }, "license": "CCBYNC", "status": "GOLD", "url": "https://pubs.rsc.org/en/content/articlepdf/2018/ra/c7ra12613a" }
A highly crystalline nanosized spinel LiMn2O4/3DG composite cathode material for high rate lithium ion batteries was successfully prepared by mixing spinel LiMn2O4 particles with reduced graphene oxide (3DG). Spinel LiMn2O4 and reduced three-dimensional graphene oxide were synthesized using a hydrothermal method and freeze-drying technology, respectively. The structure, morphology and electrochemical performance of the synthesized materials were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and galvanostatic charge–discharge techniques. The results showed that the LiMn2O4/3DG composites exhibited excellent rate capability and stable cycling performance. The discharge capacity was 131 mA h g−1 and the capacity remains at 89.3% after 100 cycles at a 0.5 C rate, while the discharge capacity was 90 mA h g−1 at 10 C. Compared with spinel LiMn2O4 materials, the LiMn2O4/3DG composites showed obvious improvement in electrochemical performance.
2022-09-02T04:02:25.070Z
43,709,043
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1046/j.1365-3148.2000.00250.x", "MAG": "2140474035", "PubMedCentral": null }, "license": null, "status": null, "url": null }
The original impetus for investigating the alloantigens and carrier glycoproteins (GP) of the platelet and granulocyte membrane came from clinical observations of pathological conditions involving antibodies against cellspeci®c antigens. Since then, dramatic progress has been made in elucidating the function, biochemical nature, and genetic basis of platelet and granulocyte membrane glycoproteins. Advances in molecular biology and monoclonal antibody techniques have enabled further characterization of both granulocyte and, especially, platelet polymorphisms and it is these polymorphisms which are the main topic of this review.
2022-09-10T18:27:36.200Z
244,182,513
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.36418/japendi.v2i9.286", "MAG": "3203139851", "PubMedCentral": null }, "license": "CCBYSA", "status": "HYBRID", "url": "https://japendi.publikasiindonesia.id/index.php/japendi/article/download/286/428" }
Latar Belakang: Penyesuaian sistem pendidikan daring pada masa pandemi COVID-19  menimbulkan banyak permasalahan baru. Tujuan: Mengetahui pengaruh on off kamera dan implikasinya pada perkuliahan daring mata kuliah islam dan sosial humaniora di fakultas ekonomi dan bisnis Islam program studi manajemen keuangan syariah UIN Sunan Kalijaga Yogyakarta. Metode: Jenis penelitian yang digunakan yaitu penelitian lapangan (field research) dengan menggunakan metode kualitatif. Hasil: Menunjukan bahwa: 1) Pelaksanaan perkuliahan yang dilakukan mahasiswa S1 Manajemen Keuangan Fakultas Ekonomi dan Bisnis Islam memanfaatkan beberapa media, diantaranya zoom meeting, google classroom, google meet, dan whatsapp group. 2) Bentuk-bentuk partisipasi mahasiswa dalam perkuliahan yang berani yaitu kemauan untuk berani berbicara, dan mendengarkan perkuliahan. 3) Menyalakan ( on ) kamera saat proses perkuliahanrimplikasi pada dampak positif yang ditimbulkan seperti peningkatan tingkat pemahaman dan fokus mahasiswa terhadap pelajaran, komunikasi, terciptanya emosi padaal, dan Kegiatan Diluar Proses Pembelajaran. 4) Dampak positif mematikan kamera saat pembelajaran, yaitu Pertama , mengurangi beban kuota yang dikeluarkan dan sinyal yang buruk, Kedua , meningkatkan kepercayaan diri karena tingkat kepercayaan diri seseorang-beda ada yang percaya diri juga off kamera ada yang lebih percaya diri dengan di kamera. Kesimpulan: Penerapan pembelajaran yang berani meningkatkan kemauan mahasiswa untuk berinteraksi, berani berpendapat, dan menyimak perkuliahan. Menyalakan ( atas ) kamera hearts Proses perkuliahan berimplikasi PADA Dampak positif Yang ditimbulkan seperti DAPAT mengukur Tingkat pemahaman Dan Fokus mahasiswa Terhadap Pelajaran, terciptanya communication, terciptanya Ikatan Emosi pada al, Dan menghindari activities PENGOPERASIAN Proses Pembelajaran.
2022-11-24T16:37:44.076Z
6,410,394
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1387/IJDB.12455619", "MAG": "2181869766", "PubMedCentral": null }, "license": null, "status": null, "url": null }
The polarizing region of the developing limb bud is one of the best known examples of a cell-cell signalling centre that mediates patterning in vertebrate embryos. This article traces some highlights in the history of the polarizing region from its discovery by John Saunders and early work that defined polarizing activity through a period in which modelling was pre-eminent, right up to the discovery of defined molecules with polarizing activity. There is a particular focus on the discovery that retinoic acid could mimic signalling of the polarizing activity and this finding is then set in the context of more recent work which implicates Shh and BMPs in mediating polarizing activity.
2022-12-20T10:32:25.723Z