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169,493,095 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.31410/TMT.2018.143",
"MAG": "2943521580",
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|
In this paper we will research the management of service marketing in modern tourism sector. The tourism market is an extremely dynamic and open system. Aiming to form and maintain long-term relation, the marketing of relations has to understand the users’ expectations, to get familiar with the user, to evaluate service processes, to get a real assessment of service quality and to manage adequately with relations. This is achieved through the interaction or active participation of all participants in the market, as well as by interacting with many other disciplines from which the tourism market collects and provides information.
|
2022-02-08T17:50:13.215Z
|
164,612,548 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1155/2019/1678393",
"MAG": "2944247502",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "http://downloads.hindawi.com/journals/sv/2019/1678393.pdf"
}
|
The tubing string exposed to transient flow may undergo nonlinear vibration due to sudden change in pressure in conveying gas. But, the drag on such structures often leads to fatigue failure of the strings that may significantly affect the vibrations through the combined effects of the first sections of gas injection, annulus pressure, the inclined structures, and the large transient flow component. In this paper, the nonlinear vibration analysis of tubing strings in underground gas storage using the multiscale wavelet transform has been studied. The vibration characteristics of strings in the steady gas injection process have been analyzed by numerical simulation. Results of the calculation model are compared to numerical ones reported previously, and the excellent agreement is obtained. The nonlinear vibration experiment of strings in the gas injection process has been studied for discussing the change rules of the string pressure, the wall velocity, and the amplitude in the gas injection process. The results show that the near-injection port section and the inclined section of strings are the high-incidence areas of nonlinear vibration of strings in underground gas storage. We also find that significant alteration of the dynamics is due to low-frequency pressure fluctuation forces on the tubing strings.
|
2022-04-08T01:34:28.633Z
|
229,049,479 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.31089/1026-9428-2019-59-5-314-318",
"MAG": "2947720484",
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|
Introduction. Vibration disease (VD) is one of the leading occupational diseases. One of the manifestations of this disease when exposed to general vibration may be a violation of balance. The aim of the study is to identify the imbalance and the causes of their occurrence in patients with vibration disease. Materials and methods. 3 groups of patients were examined. The first group consisted of 50 patients diagnosed with VD associated with combined exposure to local and general vibration (age 48.7±3.1 years); the second group consisted of 50 patients diagnosed with VD associated with exposure to local vibration (age 48.9+2.8 years); the control group consisted of 50 relatively healthy men not in contact with vibration (age 49.1+2.5 years). Survey on electronic stabilometer ST–150 (Biomera, Russia). Patients performed the Romberg test standing barefoot vertically on a stabilometric platform with a “European” stop position. Statistical processing of the results was carried out using the software package “Statistica 10.0” (StatSof, USA, 2011). Methods of descriptive statistics included estimation of median, lower and upper quartiles. The statistical significance of the differences was determined using the nonparametric Wilkinson method. Differences were considered statistically significant at p<0.05. Results. In the analysis of the obtained stabilometric parameters found that in the first group of patients marked imbalance. Moreover, in comparison with the second group and the control group in the phase with eyes closed, patients are more difficult to maintain a given posture, which increases the length of statokinesigram (p=0.02 and p=0.005), increasing the speed of movement of the center of pressure (p=0.03 and p=0.004) and the square of the deviation of the center of pressure (p=0.03 and p=0.004). When closing the eyes, patients put more effort to maintain balance, which affects the rate of mechanical work (p=0.001 and p=0.001). When comparing the second group with the control group, no statistically significant difference was found in the main stabilometric indicators. Conclusions: In the group of patients with VD associated with the combined effects of local and general vibration, marked (64%) and moderate (36%) postural disorders, especially in the phase of closed eyes. In the group of patients with VS associated with local vibration exposure and in the control group, imbalance was detected in 10% and 6%, respectively. The leading role in the occurrence of postural disorders in patients with VD, associated with the combined effects of local and general vibration, plays the formation of a focus of stagnant excitation in the centers of vibration sensitivity. In the future, the pulse can spread to nearby centers of pain, temperature sensitivity and proprioception, which contributes to the emergence of lower limb polyneuropathy and impaired stability in patients with vibration disease.
|
2022-08-19T21:44:28.236Z
|
110,968,219 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1139/L84-098",
"MAG": "2143044360",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
There are many theories pertaining to the progression of ice covers in rivers fed by frazil slush and floes but very few have been examined critically by comparing them with field data. In this paper the existing theories on dynamic ice cover progression are reviewed, an additional one is proposed, and they are classified according to the physical mechanisms that are involved. Finally, they are compared with some existing field data for large rivers. The data are extremely scarce and difficult to obtain because of the costs involved and the dangers in traveling over thin ice when the ice cover is being formed.It is usually easier to get only the critical values of parameters giving the limits of ice cover progression. In this paper, complete data were taken from the St. Lawrence River, the Beauharnois Canal, and the La Grande Riviere where the ice thicknesses along with the flow parameters have been measured.In these cases the existing data are adequate, so they could be grouped to explain the various mec...
|
2022-08-31T09:59:50.848Z
|
83,071,679 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1096/fasebj.21.6.A1263-b",
"MAG": "202562227",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Altered cardiac fibroblast function and extracellular matrix (ECM) homeostasis are the major processes during cardiac remodeling. The impaired autonomic balance and sustained sympatho‐excitation may contribute to these adverse alterations. In this study, we investigated the effect of cholinergic activity on fibroblast proliferation, collagen production, and metalloproteinase (MMP) activity in vitro using primary cultured rat neonatal cardiac fibroblast cells. The treatment with an adrenergic agonist, phenylephrine (PE, 10 uM), increased MMP9 activity, reaching 132±3 % of the control. Co‐treatment with a cholinergic agonist bethanechol (Beth, 10 uM) reversed PE‐induced increase in MMP9 activity, down to 93±5 % of the control. Beth alone did not exhibit a significant effect on MMP9 activity. Furthermore, PE increased collagen production, up to 178±16 % of the control, which was also reversed by Beth to 106±4 % of the control. Neither PE nor Beth induced significant changes in fibroblast proliferation in this study. These results suggest that parasympathetic cholinergic action may play a protective role in cardiac remodeling.
|
2022-10-14T00:50:06.700Z
|
252,835,213 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/molecules27196610",
"MAG": null,
"PubMedCentral": "9573118"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/1420-3049/27/19/6610/pdf?version=1665455949"
}
|
Abstract The hA5G18 peptide (DDFVFYVGGYPS) identified from the human laminin α5 chain G domain promotes cell attachment and spreading when directly coated on a plastic plate, but does not show activity when it is conjugated on a chitosan matrix. Here, we focused on the structural requirement of hA5G18 for activity. hA5G18 was stained with Congo red and formed amyloid-like fibrils. A deletion analysis of hA5G18 revealed that FVFYV was a minimum active sequence for the formation of amyloid-like fibrils, but FVFYV did not promote cell attachment. Next, we designed functional fibrils using FVFYV as a template for amyloid-like fibrils. When we conjugated an integrin binding sequence Arg-Gly-Asp (RGD) to the FVFYV peptide with Gly-Gly (GG) as a spacer, FVFYVGGRGD promoted cell attachment in a plate coat assay, but a negative control sequence RGE conjugated peptide, FVFYVGGRGE, also showed activity. However, when the peptides were conjugated to Sepharose beads, the FVFYVGGRGD beads showed cell attachment activity, but the FVFYVGGRGE beads did not. These results suggest that RGD and RGE similarly contribute to cell attachment activity in amyloid-like fibrils, but only RGD contributes the activity on the Sepharose beads. Further, we conjugated a basic amino acid (Arg, Lys, and His) to the FVFYV peptide. Arg or Lys-conjugated FVFYV peptides, FVFYVGGR and FVFYVGGK, showed cell attachment activity when they were coated on a plate, but a His-conjugated FVFYV peptide FVFYVGGH did not show activity. None of the basic amino acid-conjugated peptides showed cell attachment in a Sepharose bead assay. The cell attachment and spreading on FVFYVGGR and FVFYVGGK were inhibited by an anti-integrin β1 antibody. These results suggest that the Arg and Lys residues play critical roles in the interaction with integrins in amyloid-like fibrils. FVFYV is useful to use as a template for amyloid-like fibrils and to develop multi-functional biomaterials.
|
2022-12-10T09:48:34.949Z
|
27,934,196 |
{
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"ArXiv": null,
"DOI": "10.1037/0022-006X.73.2.249",
"MAG": "2025674417",
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|
Women (N=171), distressed from their partners' untreated alcoholism, received either coping skills training (CST), 12-step facilitation (TSF), or delayed treatment (DTC). CST and TSF resulted in lower depression levels than DTC but did not differ from one another. Skill acquisition mediated the treatment effects of CST; Al-Anon attendance did not mediate the TSF effect. Lower depression levels were maintained at 12 months with no differences between groups. Partner drinking decreased from pretreatment to follow-up in the CST and TSF conditions. However, for partners with a history of relationship violence, drinking improved across follow-up in the CST condition but worsened in the TSF condition. Partner relationship violence was less in the CST condition. CST may be particularly useful for women experiencing physical violence from a partner with alcoholism.
|
2022-12-15T07:52:03.717Z
|
229,038,031 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1088/1742-6596/1646/1/012134",
"MAG": "3095010916",
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://doi.org/10.1088/1742-6596/1646/1/012134"
}
|
Communication system is one of the core technologies for urban rail transit operation, and it is also the fastest growing field nowadays. The Beijing Metro wireless communication dispatching system based on TETRA is designed to solve the problem that the expensive cost of purchasing of English dispatching consoles in dedicated wireless communication system and the lack of replacement of the internal dedicated PCBs. The system is based on the existing wireless communication private network operation and maintenance auxiliary decision-making system, and is developed twice by using the API (application program interface), which is provided by MOTOROLA, and realizes the function of using PC to install the secondary development software instead of the English dispatching console dedicated PCB. It provides technological support for the upgrading of operation and maintenance in the field of rail transit communication and broadens the direction of practice.
|
2022-12-20T18:05:03.913Z
|
22,605,529 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/17457300802396487",
"MAG": "1975178477",
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"url": null
}
|
More than 90% of violence-related deaths occur in low- to middle-income countries (LMICs), where the mortality rate due to violence is almost 2.5 times greater than in high-income countries. Over and above the substantial contribution of violence as a cause of death and physical injuries, victims of violence are also more vulnerable to a range of mental and physical health problems. Several studies describe the deleterious impact of different types of violence on a range of health outcomes, but no review has yet been undertaken that presents a composite overview of the current state of knowledge in LMICs. This paper reviews the scientific literature describing the nature, magnitude and impact of violence on health, describing the current state of violence-prevention policy developments within the global health agenda and highlighting the health consequences, disease burden and economic costs of violence. Although data are limited, the review indicates that costs relating to violence deplete health care budgets considerably and that scarce resources could be better used to address other health threats that hamper development.
|
2022-12-21T18:37:00.169Z
|
9,731,802 |
{
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"ArXiv": null,
"DOI": "10.1001/ARCHNEUR.1997.00550230066019",
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"url": null
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|
OBJECTIVE
To assess the relations of 3 measures of socioeconomic status (education, occupational prestige, and income) to risk of incident clinically diagnosed Alzheimer disease (AD).
DESIGN
Cohort study with an average observation of 4.3 years.
SETTING
East Boston, Mass. a geographically defined community.
PARTICIPANTS
A stratified random sample of 642 community residents 65 years of age and older who were free of AD at baseline.
MAIN OUTCOME MEASURE
Clinical diagnosis of probable AD according to standard criteria, using structured uniform evaluation.
RESULTS
The relations of the 3 measures of socioeconomic status to risk of disease were assessed using logistic regression analyses. In individual analyses, fewer years of formal schooling, lower income, and lower occupational status each predicted risk of incident AD; risk of disease decreased by approximately 17% for each year of education. In an analysis including all 3 measures, the effect of education on risk for disease remained approximately the same, but the effects of the other 2 measures were somewhat less and did not attain formal statistical significance, compared with separate analysis of each measure.
CONCLUSIONS
Markers of lower socioeconomic status predict risk of developing incident AD. The mechanism of this relation is uncertain, but the possibility that it reflects unidentified and potentially reversible risk factors for the disease deserves careful investigation.
|
2022-12-28T14:23:32.060Z
|
240,521,293 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/app11188678",
"MAG": "3199028195",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2076-3417/11/18/8678/pdf?version=1631880623"
}
|
With the rapid increase in automobiles, the importance of reducing low-frequency noise is being emphasized for a comfortable urban environment. Helmholtz resonators are widely used to attenuate low-frequency noise over a narrow range. In this study, a slit-type soundproof panel is designed to achieve low-frequency noise attenuation in the range of 500 Hz to 1000 Hz with the characteristics of a Helmholtz resonator and the ability to pass air through the slits on the panel surface for reducing wind load. The basic dimension of the soundproof panel is determined using the classical formula and numerical analysis using a commercial program, COMSOL Multiphysics, for transmission loss prediction. From the numerical study, it is identified that the transmission loss performance is improved compared to the basic design according to the shape change and configuration method of the Helmholtz resonator. Although the correlation according to the shape change and configuration method cannot be derived, it is confirmed that it can be used as an effective method for deriving a soundproof panel design that satisfies the basic performance.
|
2022-08-28T01:02:23.031Z
|
216,130,178 |
{
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"ArXiv": null,
"DOI": "10.1080/14787210.2020.1761332",
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}
|
ABSTRACT Introduction Cysticidal drugs have improved the prognosis of thousands of patients with neurocysticercosis (NCC). However, conflicting studies have created controversies on the actual value of these drugs. Here, the reasons of these controversies, as well as evidence showing the beneficial role of cysticidal drugs are reviewed. Areas covered The present review (based on different databases searches up to March 2020), focuses on the evidence supporting the use of cysticidal drugs in patients with NCC. For parenchymal NCC, albendazole alone must be used for patients with one or two cysts, while the combination of albendazole plus praziquantel is advised for those with more than two lesions. Level I evidence on the optimal regimens of cysticidal drugs for treatment of extraparenchymal NCC is lacking, although there is growing evidence supporting the use of cysticidal drugs in these cases, providing that hydrocephalus and intracranial hypertension have previously been treated. Expert opinion With the exception of therapy of patients with viable parenchymal brain cysticerci, we are far from getting level I evidence on the best approach for each of the other forms of NCC, as most of our knowledge on therapy for extraparenchymal NCC is based on non-controlled studies or small series of patients.
|
2022-12-26T16:59:04.843Z
|
196,102,883 |
{
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"ArXiv": null,
"DOI": "10.15514/ISPRAS-2017-29(1)-8",
"MAG": "2749145940",
"PubMedCentral": null
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"license": null,
"status": null,
"url": null
}
|
This paper is dedicated to practical research in the field of automated testing and analysis of software that features a graphical user interface. Current tendencies in user interface development favour semi-automatic approaches that employ human experts to create and prepare test suites. The ever-increasing complexity of software leads to decreased effectiveness of these approaches, especially when one considers large amounts of computational resources available during development. We present a fully automatic approach to dynamic analysis of program graphical interfaces. Our approach is based on the open-source GUITAR tool, which we have identified among other industrial and academic tools as the one closest to full automation. While highly efficient, GUITAR nevertheless has certain drawbacks and limitations which might cause insufficient accuracy in modelling the graphical interface structure and its individual elements. In turn, these limitations lead to fragments of graphical interface not getting processed during analysis or cause incorrect (i.e. not reproducible in practice) test cases to be generated. Our contributions include a set of modifications: incremental graphical interface model generation, improved identification of graphical interface element attributes and side effects, and finally a test case generation algorithm that focuses on reaching unprocessed graphical interface elements to check their functionality and improve the model. We have tested our modifications on a set of open source projects originally checked by GUITAR developers and achieved positive results: increased precision of GUI structure model and theoretically can decrease number of inapplicable test cases. Finally, we discuss several potential improvements for future work, including, in particular, the use of dynamic symbolic execution methods.
|
2022-02-08T07:17:29.886Z
|
163,041,522 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1051/MBCB/2013084",
"MAG": "2098041401",
"PubMedCentral": null
},
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"status": null,
"url": null
}
|
Introduction . Le traumatisme dentaire fait partie des traumatismes oro-faciaux qui constituent 5 % de l’ensemble des traumatismes. C’est une urgence quand il s’agit de la luxation d’une dent definitive. Patients et methode . C’est une etude prospective portant sur 47 patients ayant eu une dent luxee reimplantee et contenue par un arc de Dautrey. L’objectif principal de cette etude est d’etudier les luxations traumatiques des dents permanentes et l’objectif particulier est de montrer leur incidence, le principe de la reimplantation et la contention avec un arc de Dautrey. Resultats . Cette pathologie traumatique touche en particulier les enfants de 7 a 12 ans, de sexe masculin, mais elle n’epargne pas les adultes. La majorite des dents touchees sont les incisives centrales maxillaires a cause de leur position sur le massif facial. Apres traitement, la quasi-totalite des patients ont eu un test d’immobilite positif et plus de la moitie ont un test de vitalite positif. L’immobilite peut etre le resultat d’une regeneration de l’espace desmodontal, mais elle peut traduire egalement une ankylose alveolo-dentaire ou la dent n’est plus vivante. Discussion . Cette etude montre que ce type de traitement est efficace pour conserver une dent definitive reimplantee.
|
2022-02-08T21:26:20.965Z
|
134,032,909 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.14719/PST.2018.5.1.364",
"MAG": "2781559749",
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"url": null
}
|
dulipdaniels@yahoo.co.uk Abstract Surveys carried out in the Kolli Hills of Eastern Ghats resulted in the discovery of 2 species of Symphysodontella M. Fleisch. namely S. cylindracea (Mont.) M. Fleisch. and S. involuta (Thwaites & Mitt.) M. Fleisch. of which the former is new to the moss flora of India whereas the latter is new to the moss flora of Eastern Ghats. Detailed descriptions with figures substantiated by photo plates and a key to distinguish the two species are provided. Incidentally, genus Symphysodontella is new to the moss flora of Eastern Ghats.
|
2022-05-10T00:24:34.444Z
|
122,448,020 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1103/PHYSREVA.84.052304",
"MAG": "2094967538",
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},
"license": null,
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"url": null
}
|
The applicability of entanglement percolation protocol to real Internet structure is investigated. If the current Internet can be used directly in the quantum regime, the protocol can provide a way to establish long-distance entanglement when the links are pure nonmaximally entangled states. This applicability is primarily due to the combination of scale-free degree distribution and a high level of clustering, both of which are widely observed in many natural and artificial networks including the current Internet. It suggests that the topology of real Internet may play an important role in entanglement establishment.
|
2022-09-12T18:52:09.914Z
|
229,018,919 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.32592/ircmj.2020.22.9.32",
"MAG": "3095847454",
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},
"license": "CCBYNC",
"status": "HYBRID",
"url": "https://ircmj.org/index.php/IRCMJ/article/download/32/54"
}
|
Background: The use of evidence-based dentistry (EBD) as the integration of investigations and clinical decisions has been a focus of attention in recent years.
Objectives: The present study aimed to evaluate the knowledge, attitude, and practice of EBD among Iranian dentists in 2019.
Methods: A total of 140 self-administered questionnaires with 57 items were distributed among dentists in the 2019 exhibition of Iranian dentists. Moreover, 60 self- administered questionnaires were sent to five different dentistry schools in Iran. The analyses were carried out using the Chi-square test, independent samples t-test, and Pearson correlation.
Results: A total of 119 fully-responded self-administered questionnaires were analyzed in this study. The dentists attending EBD workshops obtained significantly higher scores of knowledge. The Cochrane Library, manufacturer’s brochures, and evidence-based guidelines were used the least for clinical decisions. Consultation with colleagues, use of textbooks, and personal judgment were mostly utilized for clinical decisions. In addition, 93.3% of the participants stated sensible uncertainties in their clinical decisions. The most important barriers to EBD were the need for long discussions with patients, lack of skills in the critical appraisal of articles, and lack of motivation in dentists with the incidence rates of 62.2%, 62.2%, and 39.5%, respectively.
Conclusions: Due to the low levels of EBD knowledge among Iranian dentists, it is recommended to give further close attention to increasing the knowledge in this regard. However, their high enthusiasm for participation in EBD workshops and enhancement of EBD skills is promising.
|
2022-09-24T16:12:46.234Z
|
236,797,264 |
{
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"DOI": "10.23960/JA.V19I1.4311",
"MAG": "3116653287",
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"status": null,
"url": null
}
|
Tuberose (Polyanthus tuberosa L.) is a popular ornamental plant in Indonesia as cut flowers and sowing flowers. It can be used as potted flowers by making the flower stalks shorter. One way to get tuberose that have criteria as potted flowers is by administering growth inhibitors using Paclobutrazol. This research was conducted at the Greenhouse of the Horticultural Building, Faculty of Agriculture, University of Lampung in November to August 2017, aimed to determine the effect of the concentration of paclobutrazol on the growth and appearance of tuberose and to determine the best concentration of paclobutrazol in the appearance of potted tuberose. This study used a randomized block design (RCBD) with a single treatment with 6 levels of paclobutrazol concentration, namely 0, 75, 150, 225, 300, and 375 ppm with 3 replications. Homogeneity of variance was tested by Bartlett test and additivity was tested by Tukey test. Then, it was continued with the F test and with the Least Significant Difference test (LSD) at the 5% level. The results showed that administration of paclobutrazol was significantly affected pseudo stem circumference and all variables of generative growth except the length of the florets. The concentration of paclobutrazol up to 375 ppm has not obtained optimum results. Keywords: Concentration, growth, paclobutrazol, tuberose
|
2022-11-17T19:34:10.915Z
|
38,202,156 |
{
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"DOI": "10.1109/ESSCIRC.2009.5326011",
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|
Ultra-thin chip technology has potential to provide solutions for overcoming bottlenecks in silicon technology and for leading to new applications. This, however, requires new techniques in fabricating very thin wafers or chips, in applying them to device integration processes and in assembly and packaging. Therefore, ultra-thin chips and the related applications represent a new paradigm in silicon technology. The paper highlights the prominent applications of ultra-thin chips, alerts to the related technological issues and compares the candidate enabling technologies.
|
2022-12-12T23:59:57.022Z
|
31,747,121 |
{
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"DOI": "10.1113/expphysiol.2011.063560",
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|
Plasticity of insulin secretion is essential to maintain the action of insulin during insulin resistance and to prevent diabetes. Investigation of the plasticity of insulin secretion and its regulation is challenging, and the objective of this study was to develop a novel large‐animal‐based model. The effect of chronic moderate hyperglycaemia on the plasticity of insulin secretion, β‐cell mass and function was determined in sheep. Adolescent sheep (120 days old) were infused with 25% glucose for 16 days to increase blood glucose by 50% (n= 10), and control animals (n= 9) were infused with saline. Glucose‐ and arginine‐stimulated insulin secretion, insulin sensitivity and glucose effectiveness were measured in vivo before and during treatment (days 10–14), and β‐cell mass was measured at the end of treatment. Hyperglycaemia increased blood glucose (+53%) and plasma insulin (+403%; each P < 0.003) and did not alter whole‐body insulin sensitivity. Hyperglycaemia increased glucose‐stimulated insulin secretion (particularly second phase; five‐fold) and arginine‐stimulated insulin secretion (particularly first phase; four‐fold). Hyperglycaemia reduced β‐cell mass (∼50%, P= 0.038) and increased glucose‐ and arginine‐stimulated insulin secretion relative to β‐cell mass five‐fold (P= 0.060) and 20‐fold (P= 0.007), respectively. Chronic hyperglycaemia therefore induces marked adaptation and upregulation of glucose‐ and arginine‐stimulated insulin secretion by enhancing β‐cell function rather than increasing β‐cell mass in the sheep, consistent with long‐term adaptations seen in humans. This marked plasticity of insulin secretion in response to moderate hyperglycaemia provides a novel model for the investigation of factors affecting its capacity and underlying determinants.
|
2022-12-19T07:12:04.923Z
|
55,935,945 |
{
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"DOI": "10.1002/BSE.361",
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"url": null
}
|
Innovative financing mechanisms are needed to facilitate sustainable development. In the past few years, socially responsible investments have emerged as a successful type of financing scheme but many eco-oriented start-up companies remain under-funded. Apparently, environmental innovations have only recently caught the attention of an important financial sector: venture capital (VC). The article describes the emerging phenomenon of environment-related VC (or green VC) and provides an overview of the current market for this type of investment. The paper delves into this industry, revealing its characteristics, processes and mechanisms. The study also uncovers the main problems faced by eco-entrepreneurs as well as venture capitalists interested in this type of venture. Finally, it analyses the drivers for green VC and attempts to identify the sources of innovation and the uniqueness of these emerging financial products. Based on the analysis, the paper also derives a definition of green VC. Copyright © 2003 John Wiley & Sons, Ltd and ERP Environment.
|
2022-12-25T13:24:08.316Z
|
109,895,346 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1234/RCI.V4I1.105",
"MAG": "1841643683",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This article shows the environmental impact on the life cycle of the Jatropha curcas for its use asbiodiesel using a Numeric Matrix.The sustainability analysis was made using the matrix (22.23): thatis, 22 activities of the life cycle of the production of bio-fuel from the Jatropha Curcas Oil, in Cuba, and23 factors (13 component and 4 sub-systems) that influence in the sustainability. Each activity wasqualified according to the positive impact, negative or nil provoked. This study gives the possibility toknow how the implementation of this culture impacts in the Cuban ecosystem to produce bio-fuelfrom the Oil of Jatropha curcas.
|
2022-02-10T05:36:27.003Z
|
132,479,549 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4225/03/58B4ED304C576",
"MAG": "2593671012",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Today, designers use a diverse range of media to make more of an impact as well as producing a more efficient form of communication. As a designer and academic, concerned about my responsibility of communicating more effectively across society, my aim in undertaking this research is to investigate and demonstrate how traditional and contemporary values embedded in current design work can be expressed into a creative art form. This practice-based research conducted in Kampung Sungai Bumbun, Pulau Carey, Malaysia, is to assess whether the combination of traditionally inspired and contemporary design, will strengthen cultural identity by synthesising the indigenous cultural information into a new sculptural signage form. Specifically, I respond to the Mah Meri indigenous culture by proposing to design a new sculptural signage system as a communication tool. Even though, the Malaysian government has developed many infrastructures in this settlement, the Mah Meri community still lags behind in using new communication technology and, in my opinion, promotional media to inform and educate outside visitors is highly desirable.
The research methodology undertaken in this project consists of design processes: sketches, illustration, two-dimensional and three-dimensional modeling, multimedia, forms fabrication, and fieldwork: interviews, photographs, observations made in Malaysia and Australia. This study endeavours to enrich the cultural identity of the Mah Meri community, based on their beliefs and their deep connection to nature, and their unique use of natural materials such as wood and fibre used in masks, sculptures and woven craft. In the preliminary design process all the design works are influenced by wood art and woven craft.
After several design studies, fibre woven craft and its associated techniques best influenced the creation of the new signage system. In the construction of this design work, I define the term as a new sculptural signage system because the work can be experienced as both a sculpture and a sign. The final design project will provide relevant information and help outsiders become more aware and learn about the Mah Meri’s cultural practices.
In designing this sculptural signage work, my aim is to engage the audience with the design work in its environment as a site-referential object. The way the signage work functions is to communicate and benefit design principles in all features of the built environment, which relate to the purposeful circulation of people and their ability to mentally situate themselves in unfamiliar environmental settings. Furthermore, the combination of techniques, both traditional and contemporary, will create an aesthetic value in design principles, which utilises audience interpretations of the sculptural signage system in a public space. This project, in turn, will create a better opportunity to promote the uniqueness of the Mah Meri’s art and crafts, establishing their identity and leaving a legacy to the community and those who visit the site.
|
2022-02-09T13:33:34.483Z
|
56,677,389 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2308/isys-51885",
"MAG": "2753774276",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT We provide evidence of whether users of financial reports are accessing XBRL files, the XBRL component of an SEC filing. The possibility of exempting small companies from the XBRL mandate ...
|
2022-09-10T16:15:57.723Z
|
190,663,269 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4995/REDU.2014.5643",
"MAG": "2152053788",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
El objetivo de este trabajo era concretar el perfil de los alumnos excelentes en la universidad, de cara a precisar modelos eficaces de funcionamiento que se pudieran generalizar y ensenar, en la medida de lo posible. Para ello se recogieron datos de varios grupos de alumnos de 1o de la Universidad Politecnica de Valencia con las mejores notas de entrada de diferentes titulaciones cuyos resultados se compararon con los de alumnos de calificaciones medias. Fueron 281 estudiantes, 148 excelentes y 133 medios, elegidos como tales por las notas de la PAU, de 11 titulaciones de 9 centros de esta universidad. Se evaluaron las estrategias de aprendizaje, los enfoques y estilos de aprendizaje, las actitudes ante el aprendizaje y el auto-concepto de los estudiantes medios y excelentes de la muestra. Se analizo tambien la relacion con el sexo y con el CI. Se llevo a cabo analisis de diferencias de las variables estudiadas y tambien un CATPCA. Los resultados de ambas pruebas mostraron una alta coherencia y nos permiten concretar un perfil de los estudiantes excelentes de la muestra que presentan mejores estrategias de aprendizaje que sus companeros medios, con un claro enfoque profundo de aprendizaje predominante, que se asocia con mayor rendimiento academico, con preferencia por los estilos reflexivo y teorico de aprendizaje, con mejores actitudes ante el aprendizaje, con mejor auto-concepto academico, y con mejores calificaciones. Ademas, este perfil esta mas asociado con la mujer que con el hombre. ABSTRACT The aim of this work was to concrete the profile of excellent students at University, in order to specify effective performance models that could be generalized and thought, as much as possible. In order to do it, data from several students groups of 1st year at the Polytechnic University of Valencia were collected. These students got the best marks in the access exam to university in different degrees and their results were compared to those of average student from the same degrees. They were 281 students, 148 of them were excellent students and 133 of them were average students. They were chosen as excellent or average students for their marks in the access exam to the university. They were from 11 degrees and form 9 university centers. Learning strategies, learning approaches, learning styles, attitudes to learning and self-concept of excellent and average students were assessed. The relation of excellence with sex and IQ was also analyzed. Analyses of differences between excellent and average students in these variables was carried out and also a categorical principal components analysis (CATPCA) was performed. The results of both statistical tests were highly coherent and they allow to concrete a profile of excellent students: they manage better strategies than their average partners, they also use a deep approach to learning, associated with a higher academic performance, they prefer reflective ant theoretical learning style, with better attitudes to learning. They have better self-concept and they get better marks. Moreover, this profile is more associated with women than with men.
|
2022-12-11T03:27:25.354Z
|
26,686,538 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICDM.2001.989495",
"MAG": "1919031954",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We compare a number of data mining and statistical methods on the drug design problem of modeling molecular structure-activity relationships. The relationships can be used to identify active compounds based on their chemical structures from a large inventory of chemical compounds. The data set of this application has a highly skewed class distribution, in which only 2% of the compounds are considered active. We apply a number of classification methods to this extremely imbalanced data set and propose to use different performance measures to evaluate these methods. We report our findings on the characteristics of the performance measures, the effect of using pruning techniques in this application and a comparison of local learning methods with global techniques. We also investigate whether reducing the imbalance in the training data by up-sampling or down-sampling would improve the predictive performance.
|
2022-12-13T19:22:31.304Z
|
233,913,272 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/zaac.202000408",
"MAG": "3114768610",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GREEN",
"url": "https://orca.cardiff.ac.uk/id/eprint/138470/7/zaac.202000408.pdf"
}
|
l conductivity and chemical/thermal stability. Various applications have also been reported for the phases with different values of n, or slightly reduced rutile (TiO2). The characteristic properties of these materials depend strongly on the compositional deviation from TiO2 and the way in which the structure accommodates the deviation. Thus, an urgent requirement is to overcome difficulties in characterizing such materials at atomic resolution. Here, we trace the discovery of the Andersson‐Magneli phases, and report the application of recent developments in electron microscopy to reveal the relation, at the local level, between structural characteristics and electronic states, specifically for the materials TinO2n‐1 with n=4–8. The electrical conductivity of Ti4O7 has been reported previously to show three clearly distinct states on decreasing temperature from 300 K. For this reason, we focus on Ti4O7 as a representative example of the TinO2n‐1 phases and report structural characteristics at temperatures corresponding to each of the three different phases, focusing on the distribution of Ti3+ and Ti4+ cations from analysis of single‐crystal XRD data. Electron diffraction experiments and electrical conductivity measurements are also reported.
|
2022-12-25T17:55:27.113Z
|
252,149,523 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.52711/2231-5713.2022.00033",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Oral controlled drug delivery systems represent the foremost widespread kind of sustained drug delivery systems for the plain blessings of oral route of drug administration. Suchsystemsrelease the drug with constant or variable unleash rates. The oral controlled releasesystems show a typical pattern of drug unleash within which the drug concentration is maintained inthe therapeutic window for a chronic amount of your time (sustained release), thereby guaranteeingsustained therapeutic action. They are used as single dosage form. Present work involvespreparation and analysis of sustained release beads of beads of Meclizine Hydrochloride using Sodium alginate as natural polymer as well as Hydroxyl Propyl Methyl Cellulose K15, Sodium CMC. The technique employed for preparation of beads of the drug is ionotropic gelation.
|
2022-09-09T19:49:31.092Z
|
153,611,003 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1108/EB001272",
"MAG": "1989747359",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
I. Introduction The general manager of a state owned manufacturing plant in a developing country has to decide how to allocate production between two products. The first product is more profitable, but the second is a priority product which the government wants to produce inside the country. Demand for the second product is uncertain, so that producing too much may decrease profits without increasing market satisfaction, while producing too little could result in unfavourable government and public reaction. This problem is typical of many decision‐making situations in the modern world—the dilemma posed by multiple, conflicting objectives in an uncertain environment.
|
2022-09-13T04:27:30.985Z
|
250,855,300 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1088/0264-9381/13/8/023",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "http://arxiv.org/pdf/gr-qc/9602034"
}
|
We construct two classes of exact solutions to the field equations of topologically massive electrodynamics coupled to topologically massive gravity in 2 + 1 dimensions. The self-dual stationary solutions of the first class are horizonless, asymptotic to the extreme BTZ black-hole metric, and regular for a suitable parameter domain. The diagonal solutions of the second class, which exist if the two Chern - Simons coupling constants exactly balance, include anisotropic cosmologies and static solutions with a pointlike horizon.
|
2022-07-31T12:48:25.730Z
|
4,598,168 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/BMJ.309.6968.1533A",
"MAG": "2008849030",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A hospital paediatrician in Britain who gave excessive doses of drugs, including sedatives, to at least 12 babies has been found guilty of serious professional misconduct. A hearing of the General Medical Council's professional conduct committee directed Dr Joyce Inyang not to practise for a year except in an NHS hospital under close supervision. The committee also ordered Dr Inyang to undergo a structured programme …
|
2022-09-13T03:56:08.708Z
|
253,216,320 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.52041/iase.icots11.t2f2",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://doi.org/10.52041/iase.icots11.t2f2"
}
|
Boxplots can be used to compare distributions. However, many students do not acquire conceptual knowledge relevant for such comparisons because instructional approaches often focus on procedural knowledge. In a digital learning environment, seventeen eighth-graders (unfamiliar with boxplots) faced the problem of estimating two long jumpers’ performance based on dot plots. We investigated students’ naïve preconceptions. Findings indicate that meaningful comparisons were made if students evaluated both distributions using the same criteria. Often, performance was not evaluated with just one criterion, but several were contrasted in the responses. Two intuitive ways to quantify data variability could be identified. Although many students determined which part of the distribution lies in a defined interval, only a few students intuitively considered the spread of a fixed proportion of the distribution.
|
2022-12-10T09:48:09.059Z
|
19,528,589 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1287/opre.21.1.380",
"MAG": "2149097134",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
This note gives three new sets of necessary conditions for the existence of a solution to the multi-index problem. One includes as subsets all of the Haley conditions, and all of the 1967 Moravek and Vlach conditions; the second includes as subsets the 1967 Moravek and Vlach conditions; while the third includes as subsets both the first and second new sets of conditions.
|
2023-01-01T17:31:31.093Z
|
242,809,609 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.35940/ijitee.g6227.0881019",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://doi.org/10.35940/ijitee.g6227.0881019"
}
|
The article presents information about the composition of the equipment of resonant power transmission systems. The resonant systems of electrical energy transmission by single-wire cable or overhead lines at elevated frequency include frequency conversion devices, power transmission lines, and devices for the reverse transformation of electrical energy to the voltage required by the consumer. In contrast to traditional systems of electrical power transmission, resonant systems are being operated on an elevated frequency of 5-15 kHz, a power transmission line voltage is 1-10 kV. In this case resonant transformers are used. The frequency of the power transmission system is set by the resonant transmitting transformer; the receiving transformer is a wideband step-down one.The main components of the resonant transmitting transformer are a power resonant circuit and a step-up/step-down winding. The maximum output power of the converter depends on the voltage supplied to the circuit, circuit voltage, circuit capacitance, frequency, and other parameters. One can change the transmitted power by changing the transmission frequency, for example, for lighting systems.Due to the fact that resonant power transmission systems operating at elevated frequency are less demanding on the grounding quality, they are more efficient compared to single wire ground return line operating at a constant current and an alternating current of commercial frequency
|
2022-10-07T00:42:53.324Z
|
6,894,430 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.18632/ONCOSCIENCE.52",
"MAG": "2407131164",
"PubMedCentral": "4284623"
},
"license": null,
"status": null,
"url": null
}
|
TP53 gene mutations are present in more than half of all human cancers. The resulting proteins are mostly full-length with a single aminoacid change and are abundantly present in cancer cells. Some of mutant p53 proteins gain oncogenic activities through which actively contribute to the aberrant cell proliferation, increased resistance to apoptotic stimuli and ability to metastatize of cancer cells. Gain of function mutant p53 proteins can transcriptionally regulate the expression of a large plethora of target genes. This mainly occurs through the formation of oncogenic transcriptional competent complexes that include mutant p53 protein, known transcription factors, posttranslational modifiers and scaffold proteins. Mutant p53 protein can also transcriptionally regulate the expression of microRNAs, small non-coding RNAs that regulate gene expression at the posttranscriptional level. Each microRNA can putatively target the expression of hundred mRNAs and consequently impact on many cellular functions. Thus, gain of function mutant p53 proteins can exert their oncogenic activities through the modulation of both non-coding and coding regions of human genome.
|
2022-12-12T20:24:04.828Z
|
45,873,046 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/cphc.201601215",
"MAG": "2556273575",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Insertion of open metal sites (OMS) into metal-organic frameworks (MOFs) is a promising strategy for preparation of physical adsorbents that enable H2 storage at room temperature. Density functional theory (DFT) calculations are reported on a promising paradigm for adsorption of multiple hydrogen molecules to a single OMS attached to an MOF linker via a catechol or thiocatechol. The interactions between adsorbed H2 and the OMS are characterized with special attention to their degrees of freedom and thermal properties. By combining the present calculations with experimental data, some of these materials are predicted to have usable capacities close to the Department of Energy (DOE) 2020 target of 40 gr L-1 marking them as important synthetic targets. Surprisingly, calculations suggest that a Ca-catechol OMS retains the ability to bind up to two hydrogens even in the presence of residual solvent.
|
2022-12-19T01:07:27.462Z
|
10,378,607 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/JSAC.2011.110516",
"MAG": "2134618125",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We take an analytical approach to study fundamental rate-delay-reliability trade-offs in the context of media streaming. We consider the probability of interruption in media playback (buffer underflow) as well as the number of initially buffered packets (initial waiting time) as the Quality of user Experience (QoE) metrics. We characterize the optimal trade-off between these metrics as a function of system parameters such as the packet arrival rate and file size, for different channel models. In the first model, we assume packets arrive according to independent Poisson processes from multiple servers or peers. We use random linear network coding to simplify the packet requests at the network layer and avoid duplicate packet reception. This allows us to model the receiver's buffer as a queue with Poisson arrivals and deterministic departures. For this model, we show that for arrival rates slightly larger than the play rate, the minimum initial buffering required to achieve certain level of interruption probability remains bounded as the file size grows. This is not the case when the arrival rate and the play rate match. In the second model, we consider channels with memory, which can be modeled using Markovian arrival processes. We characterize the optimal trade-off curves for the infinite file size case, in such Markovian environments.
|
2022-12-27T18:46:25.772Z
|
255,260,072 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.29135/std.1042295",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://doi.org/10.29135/std.1042295"
}
|
Batılı sanat eleştirisi disiplininde 18. yüzyılın başında önemli bir kırılma gerçekleşti. Sözkonusu yüzyıla kadar bir sanat ürününü, özellikle de bir resmi değerlendirirken sanatçının biyografisiyle ya da şiirle yan yana getiren yaklaşımlar; görsel sanatlar eleştirisini edebi kuramlara dayalı olarak gerçekleştiriyordu. 18. yüzyılda önce Roger de Piles, ardından Jonathan Richardson, sanat eleştirisini; biçimsel niteliklerin önemine vurgu yaparak sanat eleştirisini edebiyat kuramından ayırdılar. Her ikisi de aynı zamanda ressam olan bu eleştirmenlerin çalışmaları bugün bize temelsiz ve bir sanat eserinin liyakat değerini belirleme açısından kuşkulu gibi görünebilecek nitelikte olsa da modern sanat eleştirisi temellerini onların çabalarına borçludur. Bu makalede söz konusu iki sanat eleştirmeninin, bir sanatçının ya da sanat eserinin liyakat değerini ölçmek için geliştirdikleri ölçme araçları (ölçekler) ve kuramları incelendi. Söz konusu ölçekler, 18. yüzyıl sanat eleştirisi için çok yaygın bir ilgi gördü. Sadece resim alanında değil de müzik, matematik, şiir gibi farklı alanlara uygulandılar. Romantik hareketin ortaya çıkmasından sonra, 19. yüzyılın ilk on yılından sonra bu ölçekler, kuşkulu ve yetersiz görülmeye başlandı ve ölçekler sanat eleştirisi alanında popülerliğini yitirdi. Makale literatür taramasına ve doküman incelemesine dayalı olarak gerçekleştirildi. Ana dökümanlar, Roger de Piles’nin ve Jonathan Richardson’un 18. yüzyılda yayımlanmış olan kitaplarıdır.
|
2022-12-30T17:56:13.552Z
|
155,174,091 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1504/IJARGE.2015.072900",
"MAG": "2256490723",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The paper presents the original technique of assessing the sustainable development in rural areas which is based on an integrated approach. It describes the methods and validation conducted for rural areas of the Russian Federation with the case for its exclave - the Kaliningrad region. The characteristic of its agropotential has been studied; the analysis of social, economic and environmental indicators within 20 groups of statistical data has been used to calculate a composite sustainability index. On the basis of the integrated analysis conducted, recommendations for the sustainable development of rural areas have been elaborated. It was concluded that under the conditions when the region is obliged to provide food security, detailed assessment of sustainability of agricultural areas becomes extremely important. The method of the calculation of the integrated approach to sustainable development was introduced and applied for the border rural areas of the Kaliningrad region.
|
2022-06-13T21:49:54.232Z
|
79,465,857 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1159/000051795",
"MAG": "2593385157",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://www.karger.com/Article/Pdf/51795"
}
|
The objective of this book is to provide profound knowledge of the impact of vitamins, electrolytes, trace elements, fatty acids and amino acids in the prevention and treatment of diseases caused by malnutrition and malabsorption. The book is divided into four parts covering the basics of micronutrients, the physiological and therapeutic impact of individual micronutrients and their link to civilization diseases such as diabetes, cancer and arteriosclerosis and possible therapeutic interventions. The last part of the book displays recommended daily reference doses in tables and contains a detailed glossary. The book is very well structured with short and precise sentences and well documented with good reference material. A very useful reference book for any kind of questions about micronutrients. P. Pedrazzetti
|
2022-07-01T04:59:40.426Z
|
55,093,766 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1029/2008JA013549",
"MAG": "2795881758",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We report emission characteristics of 52 chorus events on 23 August 2003 and10 events on three other days, modeled with a ray tracing technique. Chorus waves have acharacteristic frequency/time variation that is a combination of frequency separation bypropagation dispersion and a time-dependent source frequency emission drift. A cross-correlation technique comparing data from multiple Cluster spacecraft quantifies thefrequency variation owing to propagation dispersion. The comparison of the datacross correlations with the simulated cross correlations allows the identification of acorrelation region which has at least one common point with the chorus source region.Any remaining frequency/time variation in the single-spacecraft spectrograms notaccounted for by the cross correlations is then used to determine the time-dependentsource frequency emission drift. The final modeled correlation region and sourcefrequency emission drift for each chorus event is consistent with both the cross-correlationand single-spacecraft data. The modeled correlation regions are located near the magneticequator and are, in general, more extended parallel to the Earth’s magnetic field thanperpendicular to it. It is found that waves with frequencies above and below 1/2 theequatorial electron cyclotron frequency on the magnetic field line of the spacecraft (lowerand upper band, respectively) are emitted in a broad spectrum of wave normal angles.There is also some preference for lower band waves observed at the spacecraft tohave been emitted near the Gendrin angle and at earthward-pointing wave normal anglesof between 20 and 30 . The latter result is close to the range of wave normal anglesshown recently to be connected with chorus that propagates into the plasmasphereand evolves into the incoherent plasmaspheric hiss spectrum, known to be connectedto pitch angle scattering and loss of electrons in the electron slot region. Finally, thetime-dependent source frequency emission drift for these eventsranges from 1to20 kHz/s.For most events these rates account for at least 2/3 of the chorus frequency/time variationwith the rest being due to propagation dispersion.
|
2022-12-25T21:53:31.732Z
|
242,891,908 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.36341/klinikal_sains.v7i2.1089",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBYNCSA",
"status": "HYBRID",
"url": "http://jurnal.univrab.ac.id/index.php/klinikal/article/download/1089/671"
}
|
Perawatan kulit dan wajah menjadi hal yang paling utama untuk mendapatkan penampilan yang menarik. Salah satu cara agar wanita tersebut terlihat lebih cantik yaitu menggunakan kosmetik. Selama kosmetik tidak mengandung bahan berbahaya yang secara farmakologis aktif mempengaruhi kulit, penggunaan kosmetik jenis ini menguntungkan dan bermanfaat untuk kulit itu sendiri. Salah satu bahan yang berbahaya yang terdapat di dalam kosmetik yaitu merkuri. Merkuri adalah logam berat yang sangat berbahaya. Tujuan penelitian ini untuk mengetahui ada atau tidaknya merkuri dalam urin pada pengguna serum pemutih wajah.Desain penelitian ini adalah intervensional dengan jenis penelitianbersifat eksperimenyang merupakan suatu percobaan untuk mengetahui adanya kandungan merkuri di dalam sampel dengan menggunakan uji reaksi warna. Dari hasil penelitian yang telah dilakukan tentang identifikasi kandungan merkuri (Hg) pada urine pengguna serum pemutih wajah dengan uji kualitatif terhdap 15 sampel yang diperiksa sampel A positif mengandung merkuri dan sampel B, C, D, E, F, G, H, I, J, K, L, M, N, O negatif yang tidak mengandung merkuri.
|
2022-01-27T01:24:32.978Z
|
58,844,912 |
{
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"ArXiv": null,
"DOI": "10.1136/bmj.2.2702.998",
"MAG": "2061127907",
"PubMedCentral": null
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"license": null,
"status": null,
"url": null
}
|
UNIVERSITIES AND MEDICAL EDUICATION. SIR,-The illuminating article, " Universities and Medical Education," in the BRITISH MEDICAL JOURNAL of October 5th and Dr. Rolleston's address agree so far that, as the time devoted to preliminary and professional medical training is necessarily limited, the best use should be made of it as regards suLbjects, institutions, and teachers. The article reopens the evergreen discussion of classics v. mathematics, and when it draws in Locke, to be knocked out a few lines lower by Newman and Davison, it should be remembered as an extenuating circumstance that Locke had his academical training at Oxford wlien physical experiment was in the air and the Royal Society was being founded. It betrays, I think, a bias in favour of the liberal camp, but paradoxically, because it oututilitarianizes the utilitarian, of which John Hunter stands as the shining example, and all the others marshalled on the liberal or classic side. As a fact both the liberal and utilitarian school aims at the same ideal-practical efficiency-but, whilst the results of the former are more permanent and remote, the outcrop of character, the latter are more immediate, and appeal to the philistine mind. The human mind is, hiowever, so plastic that there are few errors even in training that are entirely irremediable, so that evidence is difficult to adduce in favour of one or the other. The problem is better approached from a psyclhological standpoint and the meaning made plainer by a honmely analogy. A boy is to become a carpenter or cabinet maker. The ordinary technical teacher sets him a task of box making, which excites interest because the labour is productive and directly profitable, and the use of the tools is learnt as a side issue. The university plan of "principles " would favour the handling of tools that the boy might get the widest range of use of them as instruments for his mental and manual activities, and -the box would be the by-prodtuct. The examination results would be favourable to the technical rather than the university principle of education, because, whilst it is easy to judge material results, it is difficult to ascertain to what extent capacity has been developed. Theoretically, then, the big benefits are on the liberal side. The article proceeds: " We do not want to manufacture pedants; it is the training in minute accuracy and the faculty of distinguishing fine shades of meaning thatmatter." And this applies as much to diagnosis as to literary form to which this pregnant sentence refers. Diagnosis is the essence of medicine, and depends on collecting and arranging data, and drawing correct inferences from them. Circumstantial evidence or the law of probabilities are our guiding stars. If this is admitted the problem of medical education has a more open face, and neither the Psalms nor the multiplication table, neither the dead languages nor geometry, are the only alternatives as a preparatory training for the practice of medicine, for there are other studies nearer home of an equally disciplinary virtue. The article gives the suggestion in its mention of Locke, Why should not comparative philosophies and psychology be made more iof in the curriculum? Both are bed-rock in the study of mental diseases. Again, an elementary knowledge of the principles and law of evidence could not fail to be serviceable directly and remotely, and would often prevent a stupid exhibition in the law courts whicli brings the profession into ridicule. These eircumferential subjects would bring us in better touch with our brethren of other professions, would improve us as citizens, give our opinions a sounder tone and a higher status in public estimation. Another point, not touched in Dr. Rolleston's address or the article, is the importance that professors slhould understand the art of teaching or pedagogics. It is one thing to know and another to impart. Few of us have escaped the dreary experience of dry, disconnected facts being poured out monotonously as flat as dish-water and served up tepid as a lecture. Sir WVilliam Osler's arguments against whole-time professors seem unanswerable, and in this light Dr. Rolleston's proposition of technical assistants is worth the most respectful thoughlt.-I am, etc.,
|
2022-02-11T17:10:17.002Z
|
54,642,273 |
{
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"DOI": "10.3182/20130918-4-JP-3022.00025",
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"license": null,
"status": null,
"url": null
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|
Abstract This paper proposes a MCS (Motion Control System) with trajectory tracking capability for observation class ROVs (Remotely Operated Vehicle) used to carry out automated high-resolution image capturing missions, e.g. inspections, mappings, and surveys. The trajectory tracking capability is a key feature to enable the end-users of the ROV technology to acquire sequential high-quality images at proper pace to construct consistent representations of the objects or of the environments of interest. Four degrees-of-freedom are controlled – surge, sway, heave, and yaw. The MCS consists of an output feedback control system that is composed of a high-gain state observer and a MIMO (Multiple-Input-Multiple-Output) PID (Proportional-Integral-Derivative) controller, that works aided by reference feedforward. Plant linearisation is performed aiming at improving the tracking performance. Stability and satisfactory performance for suitable and smooth reference trajectories are attained despite the presence of unmodelled dynamics, plant parameter variations, measurement noise, and environmental disturbances. Simulated results based on the model of the NTNU's ROV Minerva are presented.
|
2022-09-06T12:30:24.890Z
|
159,690,099 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S0018246X09007481",
"MAG": "1975265767",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT This article makes use of the data-rich sources, little used by historians, relating to rank and file soldiers, especially those who became Chelsea Hospital outpensioners. It particularly seeks to find out the migration history of such men in the years after Waterloo, focusing on Scots. The conclusion is that Scots were under-represented among soldiers who became imperial settlers. There appear to be good reasons for Scots finding colonial conditions uncongenial, and, in this respect, there was little difference between the ‘Napoleonic’ soldiery and the succeeding generation who belonged more definitely to an imperial service army. Most, in fact, returned to Scotland, and then to that part of the country familiar to them. Moreover, they refute an image of veterans as marginalized men. They are shown, on the whole, to have settled back into civilian society with surprising ease, law-abiding rather than lawless, respected rather than despised or feared.
|
2022-09-05T02:49:34.507Z
|
165,211,359 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.20381/RUOR-18021",
"MAG": "2788642119",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Our thesis set out to establish the extent of the fixed image of Mahomet and his followers in Middle English works. On the basis of our knowledge of image consciousness, we examined the mystery cycles and assessed the tone and temper of Mahomet references there. To these we added an examination of two non-cyclic plays, the Digby "Mary Magdalene" and "The Croxton Play"of the Sacrament. Examination of the Cursor Mundi discovered a use of the Mahomet image similar to that employed in the above mentioned plays. Moving from the religious area, our study examined the secular romances, discovering once again, the pervasive Mahomet image along with his followers, the Saracens. Lydgate's Fall of Princes yielded images of Mahomet as a detestable false prophet and heretic. Mandeville recounted pejorative pictures of the habit and manners of his followers. That two images of Mahomet as a pagan god and as a false prophet could exist simultaneously, indicated the readiness with which people accept and enjoy literary stereotypes . An Appendix indicated that certain voices were raised against the image as a product of crusading zeal and advocated instead of hatred, love and understanding. The dissident ^ni^oo nf Langland, Gowsr and Manrievil 1g a-rgnpj hy pnnt.rast, UNIVERSITY OF OTTAWA SCHOOL OF GRADUATE STUDIES UNIVERSITE D-OTTAWA ~ ECOLE DES GRADUES the almost universal acceptance of the image of the foe. UNIVERSITY OF OTTAWA SCHOOL OF GRADUATE STUDIES
|
2022-09-08T02:51:33.153Z
|
134,570,138 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.15359/RCA.52-1.5",
"MAG": "2778636664",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Greenhouse gas and criteria pollutants emissions as well as the potential for electric power generation were estimated for four different scenarios of final disposal of solid urban waste (MSW) in San Jose: landfill, incineration, composting and mechanical-biological treatment. Generation and composition waste data reported by the San Jose Department of Environmental Services were used as input for a life cycle analysis as well as the respective materials and energy flows for each proposal, based on the formulation of the respective balances of mass and energy. The final disposal in landfills is the treatment that emits more emissions of greenhouse gases with 532.5 Ton CO2e / d and a potential of electricity generation of up to 73.45 MWh, followed by the incineration of MSW with 401.9 Ton CO2e / d. However, alternative scenarios such as incineration additionally generate significant emissions of air pollutants such as particulates (5.14 Ton / d), NOx (0.75 Ton / d) and CO (0.13 Ton / d).
|
2022-09-10T18:11:36.132Z
|
97,732,824 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.1002/CRAT.2170240822",
"MAG": "2047498560",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Investigations on the temperature variation of specific volume and ultrasonic velocity are carried out to study the phase transitions in the liquid crystals 4′-n-Pentyloxy-4-Cyanobiphenyl (50CB) and 4′-n-Octyloxy-4-Cyanobiphenyl (80CB). From these studies various parameters like the adiabatic compressibility (βad), molar sound velocity or Rao number (Rn), molar compressibility (B), Van der Waals constant (b) and the intermolecular free lengths (L) are estimated as a function of temperature in the isotropic as well as in the mesophases. Finally the variation of the order parameter with temperature in the nematic phase is studied and the results are discussed.
|
2022-12-11T21:08:09.090Z
|
129,052,526 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.22435/MPK.V24I1.3487.50-56",
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"license": null,
"status": null,
"url": null
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|
Abstrak Penyakit Kecacingan tersebar luas, baik di pedesaan maupun di perkotaan. Penyakit kecacingan di Indonesia masih merupakan masalah kesehatan masyarakat karena prevalensinya yang masih sangat tinggi yaitu antara 45-65%. Penelitian ini bertujuan untuk mengetahui prevalensi dan hubungan antara pengetahuan, perilaku dan sanitasi lingkungan dengan angka kecacingan pada anak Sekolah Dasar (SD) di Kota Palu. Penelitian dilakukan di Kelurahan Watusampu dan Kelurahan Lolu Utara di Kota Palu, Sulawesi Tengah selama delapan bulan, yaitu bulan April sampai November 2011. Penelitian ini merupakan penelitian observasi dengan menggunakan disain cross sectional study. Data dikumpulkan dengan cara wawancara dan pengambilan sampel tinja dari 288 siswa SD. Pemeriksaan tinja dilakukan di Balai Litbang P2B2 Donggala dengan penggunakan metode langsung. Pengumpulan tinja dilakukan selama tiga hari berturut-turut setelah kunjungan ke sekolah. Hasil penelitian menunjukkan bahwa dari 288 sampel, 90 sampel adalah positif terinfeksi cacing. Jenis cacing paling dominan menginfeksi adalah Ascaris lumbricoides (83,34%). Prevalensi kecacingan pada anak SD di Kota Palu sebesar 31,6%. Tidak ada bukti yang cukup menunjukkan hubungan antara pengetahuan, perilaku, dan sanitasi lingkungan dengan angka kecacingan pada anak SD di Kota Palu. (p-value > 0,05; p = 0,466, p = 0,382, p = 0,349). Kata kunci: prevalensi kecacingan, anak sekolah dasar, pengetahuan, perilaku, sanitasi lingkungan, Kota Palu Abstract Soil transmitted helminth diseases are wide spread in urban and rural areas. Soil transmitted helminth disease is still a public health problem in Indonesia due to the prevalence is still high with range 45-65%. The aim of this study was to determine the prevalence and the association between knowledge, practice, and environmental sanitation and soil transmitted helminth disease prevalence in elementary school students in Palu Municipality, Central Sulawesi. This study was carried out in Watusampu and Lolu Utara villages in Palu Municipality, Central Sulawesi for eight months, from April to November 2011. This was an observational study with a cross-sectional design. Data were collected from interview and stool examination of 288 students. The stool samples were examined in laboratory of vector borne disease research and development by using “direct method”. The stool samples were collected for three days in a row after visiting schools. The results showed that from 288 samples, 90 samples were positive for soil transmitted helminth. Most of the samples were positive for Ascaris lumbricoides (83.34%). The prevalence of soil transmitted helminth in elementary school students in Palu Municipality was 31.6%. There was no evidence of the association between knowledge, practise, and enviromental sanitation and soil transmitted helminth disease in elementary school students in Palu Municipality (pvalue > 0.05; p = 0.466, p = 0.382, p = 0.349). Key words : Soil transmitted helminth prevalence, elementary school student, knowledge, practise, enviromental sanitation, Palu Municipality
|
2022-12-16T17:31:40.331Z
|
14,211,250 |
{
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"ACL": null,
"ArXiv": "gr-qc/9804061",
"DOI": "10.1088/0264-9381/16/4/024",
"MAG": "3100670037",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "http://arxiv.org/pdf/gr-qc/9804061"
}
|
A classical continuum theory corresponding to Barrett and Crane's model of Euclidean simplicial quantum gravity is presented. The fields in this classical theory are those of SO(4) BF theory, a simple topological theory of an so(4)-algebra-valued 2-form field, , and an SO(4) connection. The left-handed (self-dual) and right-handed (anti-self-dual) components of B define a left-handed and a, generally distinct, right-handed area for each spacetime 2-surface. The theory presented is obtained by adding to the BF action a Lagrange multiplier term which enforces the constraint that the left- and the right-handed areas should be be equal. The solution space of the theory has six branches, two of which reproduce Euclidean general relativity (GR). The other four branches are also characterized and it is shown that the GR branches are stable in the sense that non-degenerate initial data of a solution in one of the GR branches does not, except in special cases, admit an alternative development in another branch. Finally, the path-integral quantization of the theory is discussed at a formal level and a heuristic argument is given suggesting that in the semiclassical limit the path integral is dominated by solutions in one of the non-GR sectors, which would mean that the theory quantized in this way is not a quantization of GR.
|
2022-12-19T00:44:36.356Z
|
174,799,479 |
{
"externalids": {
"ACL": null,
"ArXiv": "1906.01865",
"DOI": "10.1115/1.4046821",
"MAG": "3014423034",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "http://arxiv.org/pdf/1906.01865"
}
|
The paper deals with the studies of the nonlinear wave solutions supported by the modified FitzHugh–Nagumo (mFHN) system. It was proved in our previous work that the model, under certain conditions, possesses a set of soliton-like traveling wave (TW) solutions. In this paper, we show that the model has two solutions of the soliton type differing in propagation velocity. Their location in parametric space, and stability properties are considered in more details. Numerical results accompanied by the application of the Evans function technique prove the stability of fast solitary waves and instability of slow ones. A possible way of formation and annihilation of localized regimes in question is studied therein too.
|
2022-12-21T19:15:02.647Z
|
67,859,282 |
{
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"ArXiv": null,
"DOI": "10.1371/journal.pone.0206770",
"MAG": "2949265967",
"PubMedCentral": "6374013"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0206770&type=printable"
}
|
A bilingual advantage in a form of a better performance of bilinguals in tasks tapping into executive function abilities has been reported repeatedly in the literature. However, recent research defends that this advantage does not stem from bilingualism, but from uncontrolled factors or imperfectly matched samples. In this study we explored the potential impact of bilingualism on executive functioning abilities by testing large groups of young adult bilinguals and monolinguals in the tasks that were most extensively used when the advantages were reported. Importantly, the recently identified factors that could be disrupting the between groups comparisons were controlled for, and both groups were matched. We found no differences between groups in their performance. Additional bootstrapping analyses indicated that, when the bilingual advantage appeared, it very often co-occurred with unmatched socio-demographic factors. The evidence presented here indicates that the bilingual advantage might indeed be caused by spurious uncontrolled factors rather than bilingualism per se. Secondly, bilingualism has been argued to potentially affect working memory also. Therefore, we tested the same participants in both a forward and a backward version of a visual and an auditory working memory task. We found no differences between groups in either of the forward versions of the tasks, but bilinguals systematically outperformed monolinguals in the backward conditions. The results are analyzed and interpreted taking into consideration different perspectives in the domain-specificity of the executive functions and working memory.
|
2022-12-23T02:05:21.038Z
|
155,656,310 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2139/SSRN.1595590",
"MAG": "2264356665",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In recent years the German courts have been increasingly faced with claims for restitution of payments to so-called “gift communities” (“Schenkkreise”), which have become widespread in Germany and whose economic damage is enormous. They mostly involve four-level hierarchical snowball or pyramid structures. The members at the bottom level (“givers”) pay contributions, which, depending on the individual scheme, can vary between 100€ and 5000€, to members occupying the top level of the structure (“receivers”), who then drop out of the game. The givers then move up a level, but for their own part must recruit new givers to constitute the level below them. This generally means that after each “round” eight new givers must be found for each receiver. Thus, the number of new members to be recruited increases exponentially throughout the duration of the scheme. The ultimate consequence is that only the founders of these communities attain a guaranteed profit, whereas the subsequent members, by reason of the large number of new members to be recruited, barely have a realistic chance of making a profit themselves; rather, they inevitably lose their contributions. A new member, who has already paid, can only maintain the (albeit merely theoretical) possibility of one day becoming a receiver himself, if he finds new victims. In the cases which appeared before the German courts the victims, many of whom had subsequently grouped themselves together, claimed restitution of the sums paid to the respective members above them in the pyramid structure. Some courts denied restitution of the contributions, others by contrast allowed the victims’ claims and thus enabled them to get their money back These contradictory judgments led to considerable legal uncertainty in Germany. This called for action by the Bundesgerichtshof (German Federal Supreme Court). In two identical judgments of 10.11.2005 the highest German civil court sided with the victims and allowed them to claim restitution of their money and thereby put an end to the conflict which had been smoldering for years Because of the significance of the judgments and the doctrinal issues they had to resolve, especially that of application of a bar on restitution where both parties are engaged in conduct contrary which offends good morals according to § 817, 2nd sentence BGB (German Civil Code), it is worth taking a closer look at the decisions and their reasoning.
|
2022-02-09T01:12:26.821Z
|
148,413,804 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4018/978-1-4666-9577-1.CH013",
"MAG": "2488845773",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This chapter examines online learning practices and related administrative concerns at a small college just outside of New York City where educators constantly seek to meet the evolving needs of learners. The learning environment consists of multiple factors that influence social exchange and academic achievement. Learning and consequently degree completion appears limited in part because there are insufficient avenues for self-expression, social connections, and communication exchange, considered antecedents to academic achievement. In this case study, the institution serves as the research site for identifying impediments to an effective learning environment, assessing current technologies in education, and identifying strategies that educators and administrators may implement as they actively enhance learners’ academic engagement and achievement. The study presents an evaluation of the institution, its current practices, obstacles, assessment of risks, and recommendations toward conventions of traditional Learning Content Management Systems (LCMS) and organizational infrastructure. Through others, we become ourselves. ~Vygotsky INTRODUCTION: ONLINE LEARNING BY DESIGN In contemporary society, Web 2.0 has become a pervasively used tool due to its expansive reach that connects learners from diverse locations, cultures, and learning spaces via an online learning portal. Sayyid Cato Keiser University, USA Rehana Seepersad Florida International University, USA
|
2022-02-09T04:53:25.651Z
|
108,766,883 |
{
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"ArXiv": null,
"DOI": "10.1061/9780784412367.060",
"MAG": "2019063502",
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},
"license": null,
"status": null,
"url": null
}
|
Transverse cracks frequently develop on concrete bridge decks. The materials used at this time to fill and seal the transverse, longitudinal, and other cracks on bridge decks have an elongation factor of 10%. It has been observed that once applied and cured, the crack filling material fails once loads are applied and deflections occur. Once the filling material fails, it becomes partially functional only, and in many instances water or moisture penetrates the crack again. An experimental study for the Florida Department of Transportation (FDOT) had been completed to better understand the performance of four different types of sealant materials and their structural performance. This research utilizes finite element methods to model and simulate the behavior of the tested bridge deck without the crack filling materials. Three-dimension finite-element (FE) models for the decks were developed using ANSYS (simulation software). The models were used to evaluate behavior of deck before cracks were formed to identify crack formation and propagation. Cracked decks without sealing fills were also modeled and analyzed to investigate the performance of the decks after cracking. The models were utilized to study the mechanism of crack development. Computational results were compared to experimental results and are in good agreement. The models will be used to examine alternate methods of controlling or preventing cracking and to study the effects of different load patterns, load magnitudes, deflection limits, bridge span length, bridge continuity, and structural system (simply supported and continuous spans).
|
2022-02-10T06:53:49.979Z
|
32,919,421 |
{
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"ArXiv": null,
"DOI": "10.1080/10428190701644322",
"MAG": "2096619690",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Hemophagocytic lymphohistiocytosis (HLH) is characterized by fever, splenomegaly, cytopenia, hypertriglyceridemia and/or hypofibrinogenemia, hemophagocytosis, low or absent natural killer (NK)-cell activity, increased levels of serum ferritin, and increased levels of soluble interleukin (IL)-2 receptor in the serum and the cerebrospinal fluid [1]. It is proposed that the diagnosis of HLH can be established if five of these eight criteria are met [1]. Other less-common features include lymphadenopathy and skin rash. HLH can be classified as primary or secondary HLH. Primary HLHs include several types of familial HLHs (FHLs) [2 – 4] and the HLHs associated with primary immune deficiencies, and shows continuous or recurrent hemophagocytosis. Secondary HLHs include HLHs associated with infections, malignancies, or autoimmune diseases, and are not usually recurrent. Both primary and secondary HLH can be fatal. Kikuchi’s disease (KD; also known as Kikuchi – Fujimoto disease or subacute histiocytic necrotizing lymphadenitis) is characterized by fever, fatigue, and lymphadenitis. Affected lymph nodes show patchy necrotic areas with karyorrhexis surrounded by activated histiocytes. The cause of KD is still unknown. Although an infectious etiology is suspected, bacteria, fungi, toxoplasma, and Epstein-Barr virus (EBV) have been shown not to be associated with the disease. KD is benign and shows a self-limited clinical course [5,6]. Only 11 cases of concurrent HLH and KD have been reported, none of which was recurrent [7 – 16]. To our knowledge, this is the first report of a case of recurrent HLH accompanied by KD. The patient was a 13-year-old Japanese boy with atopic dermatitis and bronchial asthma, but who was otherwise healthy. Left inguinal tender lymphadenopathy appeared 2 weeks before hospitalization and ameliorated without any medication within 1 week. Fever and tender lymphadenopathy of the left axillary and right inguinal lymph nodes appeared 2 days before hospitalization. Hepatosplenomegaly was noticed upon hospitalization. Laboratory examinations showed marked leukopenia (white blood cell count 1.7610/l; absolute neutrophil count 0.37610/l), mild thrombocytopenia (13.5610/l), hypertriglyceridemia (306 mg/dl), low NK-cell activity (15%, normal range 18 – 40%), and an increased level of soluble IL-2 receptor (982 U/ml). The bone marrow (BM) was hypocellular, which was confirmed by both aspiration and biopsy, and revealed increased number of histiocytes (9.5%), most of which showed hemophagocytosis [Figure 1(a)]. These results showed that five of the eight diagnostic criteria for HLH were met [1]. The karyotype of BM was 46, XY [12/12]. Clonal rearrangements of the TCRG and IgH genes were not detected. PCR assays for cytomegalovirus (CMV), parvovirus B19, and hepatitis C virus (HCV), and serological assays for rubella, hepatitis B virus (HBV), and EBV did not indicate that the HLH was associated with any of these viruses. Results of cerebrospinal fluid assays and cranial magnetic resonance imaging showed no abnormalities. The patient did not have albinism,
|
2022-08-23T21:20:05.047Z
|
87,990,171 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1093/JEE/85.2.601",
"MAG": "2322721466",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The corn earworm, Helicoverpa zea (Boddie), is the most important pest of corn, Zea mays L., in the southeastern United States. This study was conducted to determine whether tolerance or antibiosis mechanisms (or both) of resistance function in 18 populations of corn that are being developed for resistance to ear and leaf damage in the field to the corn earworm and fall armyworm, Spodoptera frugiperda (J. E. Smith). The populations and resistant and susceptible checks were evaluated in the field for corn earworm injury and husk tightness and in the laboratory for feeding responses of neonate corn earworm larvae on fresh silks or oven-dried silks mixed in a meridic diet. Several populations approached the resistance level of the resistant check, ‘Zapalote Chico’, to ear damage in the field, but none equaled ‘Zapalote Chico’ in husk tightness. In 1987, the growth reduction of corn earworm larvae that were fed silk-diets of five populations was similar to the growth reduction of larvae that were fed a silk diet of ‘Zapalote Chico’. In 1988, only one population showed a growth reduction similar to that of ‘Zapalote Chico’, However, none of the populations approached the level of resistance exhibited by ‘Zapalote Chico’ when other antibiotic measurements such as development time and weight of pupae were considered. Based on data from both the field and laboratory, the resistance of recently released populations, ‘DDSA(C5)’ and ‘DDSB(C5)’, is primarily tolerance. Tolerance to ear damage in the field is also present in the 18 populations evaluated, although a few populations also possess a minor level of antibiosis.
|
2022-08-27T18:34:19.470Z
|
20,941,049 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/FIE.2014.7044049",
"MAG": "2024746811",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Photo-voltaic generators are no longer an energy source mainly useful for off-grid applications, such as satellites. Their presence in the energy mix of developed countries has substantially increased. Moreover, their price downward trend, together with the upward trend of electric energy prices, might increase their role, if allowed by the legal context. The behavior of photo-voltaic generators is complex, especially under partial shading. In order to enhance the learning of their characteristic current-voltage curve, the paper presents an easy and fast to apply model. The state of the art for modelling photo-voltaic cells has been reviewed. Upon the different types of models, a balanced option between complexity and precision has been chosen. Then, a model of a panel is built, by connecting an arbitrary number of cells, with an arbitrary number of bypass diodes. An arbitrary number of panels are connected to construct a string, including the correspondent blocking diode, and a set of strings constitute the generator matrix of panels. The model has been implemented in Matlab. Finally, several exercises have been developed, following a "learning by doing" methodology: students learn, from the influence of the cell parameters on its current-voltage curve, to the generator behavior under partial shading.
|
2022-02-12T21:34:35.370Z
|
229,072,313 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.46608/primaluna5.9782858926183",
"MAG": "3100503088",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://ressources.una-editions.fr/s/zzkD7bYm8dstrC6/download/PRIMALUN@_5_MANTEROLA.pdf"
}
|
L’ouvrage analyse une vaste fresque au cœur des transformations de l’État, des régions et des secteurs d’activité, en s’engageant dans un dialogue interdisciplinaire. Il contribue à la compréhension des dynamiques territoriales contemporaines de l’Économie sociale et solidaire, à travers deux secteurs d’activité (insertion par l’activité économique, aide à domicile). Il montre que cette construction territoriale s’inscrit dans le temps long et qu’elle obéit tout à la fois à des logiques sectorielles, culturelles et institutionnelles. Les études de cas approfondies (les deux versants du Pays basque) permettent de donner une consistance sociale et politique inédite à des processus qui restent parfois assez désincarnés. La dimension comparative constitue un apport original du travail. Ce travail compare certes deux territoires frontaliers, mais dont les formes d’institutionnalisation et de structuration restent relativement étanches, s’agissant du social, sous influence de régimes d’Etat providence distincts. La comparaison, déployée selon une méthodologie similaire des deux côtés, force à mettre en discussion des modèles différents de territorialisation des politiques publiques. La thématique peut être considérée d’importance majeure en matière politique et socioéconomique, dans un contexte de crise sociale et économique, de détérioration des régimes d’État providence et de resserrement des politiques publiques. L’approche fine (une centaine d’entretiens), à partir de controverses sur les valeurs, conduit à se distinguer d’autres travaux postulant une certaine naturalisation de l’ancrage de l’ESS dans les territoires, et elle vient questionner la notion d’innovation sociale.
|
2022-04-30T12:28:54.365Z
|
221,387,188 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/EMBC44109.2020.9175848",
"MAG": "3082133575",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Over the last decade Vibro-Acoustic Therapy (VAT) was used for several clinical applications. This paper investigates the use of AcusticA®, an innovative VAT solution represented by a wooden chaise longue that follows the construction principles of a "musical instrument that stimulates the whole body" in relation to the sound frequencies produced by the music tracks. Ten healthy young subjects were enrolled for this study. Wearable sensors were used to monitor the human physiological response during the VAT session but also during a traditional acoustic therapy (AT) to highlight similarity and differences of those stimulations. Signals from heart activity, brain activity and electrodermal activity were analyzed to investigate the response during the non-stimulated and the stimulated phases. Additionally, two supervised classification algorithms were used to investigate whether the extracted instances could be grouped into two different groups. The results identify a trend of the attention and meditation features extracted from brain activity, which pointed out the relax efficacy of the VAT.Clinical Relevance - There are not significant differences (p<0.05) in the physiological response between the VAT and the AT stimulation, but during the VAT the alpha coefficients were significant different during the stimulated phase. Finally, the classification algorithms were able to classify the groups with an accuracy equal to 100% in the best case.
|
2022-06-27T01:07:06.503Z
|
201,739,341 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ISSE.2019.8810272",
"MAG": "2970500682",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The Sn thin film on Cu substrate has high Sn whisker growth susceptibility because of the intensive Cu6Sn5 intermetallic formation at the Sn-Cu interface. In this study, the whisker development on vacuum evaporated Sn thin film deposited on Cu substrates was investigated, starting directly from the Sn deposition. The aim was to obtain more information about the whiskering behavior of Sn thin film in the early stage of the life cycle. For the study, 99.99% pure tin was vacuum evaporated onto Cu substrates. Two different Cu substrates were applied with different surface roughness to investigate the effect of surface roughness on the whisker development. The average thickness of the evaporated Sn layer was ~2 μ m. Samples were stored at room temperature for 10 weeks. Whisker development was observed by scanning electron microscope. It was found that the large compressive stress in the Sn layer because of the intermetallic formation initiates the whisker development even after 1 day of the Sn layer deposition. Almost only filament type whiskers were detected. The characteristics of the whisker density showed exponential saturation up to 10 days of the study, while the length of the whiskers was growing further still the end of the study. It was also found that the surface roughness of the Cu substrate affects the rate of whisker growth.
|
2022-09-08T21:00:30.425Z
|
30,383,781 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2105/AJPH.2006.092320",
"MAG": "2125867220",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
OBJECTIVES
We reviewed literature on comparative social policy and life course research and compared associations between health and socioeconomic circumstances during an 11-year period in the United States and the United Kingdom.
METHODS
We obtained data from the US Panel Study of Income Dynamics and the British Household Panel Survey (1990-2002). We used latent transition analysis to examine change in self-rated health from one discrete state to another; these health trajectories were then associated with socioeconomic measures at the beginning and at the end of the study period.
RESULTS
We identified good and poor latent health states, which remained relatively stable over time. When change occurred, decline rather than improvement was more likely. UK populations were in better health compared with US populations and were more likely to improve over time. Labor market participation was more strongly associated with good health in the United Kingdom than in the United States.
CONCLUSIONS
National policies and practices may be keeping more US workers than UK workers who are in poor health employed, but British policies may give UK workers the chance to return to better health and to the labor force.
|
2022-12-18T00:05:45.167Z
|
94,885,860 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1039/B210582A",
"MAG": "2031376721",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A novel frustrated liquid-crystalline phase was obtained in some binary mixtures between polar non-symmetric dimeric liquid crystals; it appeared below nematic or smectic A phases and was found not to possess a clear layered structure.
|
2022-12-20T13:59:28.954Z
|
41,175,589 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/J.1574-6968.1999.TB13589.X",
"MAG": "2035353182",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this study we first evaluated the effects of hydrogen peroxide (H2O2) on growth and selected properties of Porphyromonas gingivalis, and compared them with those obtained by a reducing agent (cysteine). The growth of P. gingivalis was only moderately affected when H2O2 was added at concentrations up to 30 mM in a complex culture medium. However, when a defined basal medium was used, H2O2 at a concentration of 3 mM completely inhibited growth of P. gingivalis. Incorporation of cysteine at concentrations up to 30 mM in both media had no effect on growth. The effects of H2O2 and cysteine on cell-associated hemagglutinating and Arg-gingipain activities were evaluated using bacteria grown in the complex culture medium. Both activities were strongly decreased when H2O2 was added in the assay mixtures. This inhibitory effect of H2O2 was reversible. On the other hand, including cysteine in the assay mixtures increased both activities. H2O2 and cysteine had no effect on the expression of heat shock protein (HSP)-68 and HSP-75 by P. gingivalis, as determined by SDS-PAGE and Western immunoblotting analysis. In the second part of the study, we tested whether growth of selected oral bacterial species may modify the oxidation-reduction potential (Eh) of the environment. It was found that certain species were able to either decrease (P. gingivalis, Fusobacterium nucleatum, Peptostreptococcus micros, Streptococcus mutans) or increase (Streptococcus sanguis) the Eh of the medium. Our study provides evidence that an oxidizing agent such as H2O2 may affect the biology of P. gingivalis. Moreover, growth of some members of the oral microflora can generate oxidizing and reducing conditions, and thus potentially influence the ecology of subgingival sites by affecting strictly anaerobic bacteria such as P. gingivalis.
|
2022-12-23T02:24:33.626Z
|
10,346,525 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1159/000458981",
"MAG": "2398441226",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The purification of glutamine synthetase (GS) from rat liver demonstrates that a small portion of glutamine-hydroxylamine-glutamyltransferase activity (GT) remains associated with GS activity (GT(S)). As GS is purified from the water extract, the ratio between GT(S) activity (GT(T)) is left to be extracted by KC1 from the pellet and, on further purification, appears to be independent of GS activity. Subtle differences in pH optimum, substrate requirement and reaction rates on addition of cofactors and amino acids in vitro and in responses to hormonal stimuli in vivo indicate that the glutamine transfer reaction may be catalyzed by two distinguishable proteins; only the minor component may be identical to GS.
|
2022-02-13T06:32:55.583Z
|
209,676,840 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.18632/aging.102600",
"MAG": "2997943836",
"PubMedCentral": "6949054"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://doi.org/10.18632/aging.102600"
}
|
Docetaxel is a first-line anticancer drug widely used in the treatment of advanced prostate cancer. However, its therapeutic efficacy is limited by its side effects and the development of chemoresistance by the tumor. Using a gene differential expression microarray, we identified 449 genes differentially expressed in docetaxel-resistant DU145 and PC3 cell lines as compared to docetaxel-sensitive controls. Moreover, western blotting and immunohistochemistry revealed altered expression of S100A4, ACKR3 and CDH1in clinical tumor samples. Cytoscape software was used to investigate the relationship between critical proteins and their signaling transduction networks. Functional and pathway enrichment analyses revealed that these signaling pathways were closely related to cellular proliferation, cell adhesion, cell migration and metastasis. In addition, ACKR3 knockout using the crispr/cas9 method andS100A4knockdownusing targeted shRNA exerted additive effects suppressing cancer cell proliferation and migration. This exploratory analysis provides information about potential candidate genes. It also provides new insight into the molecular mechanism underlying docetaxel-resistance in androgen-independent prostate cancer and highlights potential targets to improve therapeutic outcomes.
|
2022-02-25T21:32:28.153Z
|
96,634,161 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1039/C3RA41361F",
"MAG": "2046661259",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Sr–Zn ferrite composites were synthesized by chemical coprecipitation with different sintering process. The composites were characterized by XRD, XPS, IR, VSM, and N2-adsorption. The results revealed that the composites were composed of S-type ZnFe2O4 and M-type SrFe12O19. Zn2+ ions inserted and occupied the 12k or 2a sites for Fe3+ ions in M-type SrFe12O19. The Zn2+ ions were therefore not on the external surface of the composites. The microwave absorption properties at a frequency range of 0–18 GHz were estimated using the electromagnetic parameters obtained through the agency of microwave vector network analyzer. The microwave absorbing properties of composites were excellently superior to that of the pure SrFe12O19 or ZnFe2O4 due mainly to the exchange coupling between the hard- and soft-magnetic phases. The synthesis process was found to facilitate mass production for various composite materials, especially the two phases or multiphase composite materials.
|
2022-11-25T19:09:18.009Z
|
252,559,308 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.33179/bsv.99.svi.11.cmc.24.4.5",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://doi.org/10.33179/bsv.99.svi.11.cmc.24.4.5"
}
|
Since anisomorphism, the absence of an exact correspondence between words in two different languages, often impedes the process of second language (L2) acquisition, L2 teachers need to recognize effective methods for dealing with it. In an experiment involving a total of 109 students, we tested several methods of teaching English language military vocabulary particulars which lack direct Polish language equivalents. The results suggest that L1 translation is less effective in dealing with lexical gaps than monolingual explanations, presentation of the terminology in context, and illustrating its meaning with examples. However, the results also indicate that the use of L1 for contrastive analysis may help students cope with anisomorphism. Key words English for specific purposes, military terminology, vocabulary teaching, pomenska neprekrivnost, anisomorphism.
|
2022-11-25T00:55:30.606Z
|
225,249,490 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.35211/2500-2635-2020-3-43-109-122",
"MAG": "3092188627",
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://doi.org/10.35211/2500-2635-2020-3-43-109-122"
}
|
. This article deals with the analysis of possible basic personnel problems in a road-transport industry of the Volgograd region and their reasons which include the raise of an average age of specialists, a lack of specialists of lower and middle rank, insufficient number of graduate students of a road educational program specialization, low order for target training of specialists for the road-transport industry of the Volgograd region, employment of graduates outside the territory of the Volgograd region, low entrance salary, which is offered to the graduate students during their employment, insufficient implementation of the programs of social adaptation and consolidation of young specialists at the enterprises of the road-transport industry.There is made a conclusion that it is necessary to solve problems, connected with improvement of quality of the applicants who apply for road-transport majors of study, expanding targeted training of specialists, organizing practical-oriented training of students in road transport areas, and modernizing educational programs in accordance with the needs of the region,their orientation towards world trends.All proposed solutions are basedon the experience of the university’s international activities and cooperation with leading EU educational centers. The issues of specialists training using distance education technologies are considered.
|
2022-12-14T11:45:46.016Z
|
980,167 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1523/JNEUROSCI.20-01-00076.2000",
"MAG": "1865664127",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The functional properties of most sodium channels are too similar to permit identification of specific sodium channel types underlying macroscopic current. Such discrimination would be particularly advantageous in the nervous system in which different sodium channel family isoforms are coexpressed in the same cell. To test whether members of the μ-conotoxin family can discriminate among known neuronal sodium channel types, we examined six toxins for their ability to block different types of heterologously expressed sodium channels. PIIIA μ-conotoxin blocked rat brain type II/IIA (rBII/IIA) and skeletal muscle sodium current at concentrations that resulted in only slight inhibition of rat peripheral nerve (rPN1) sodium current. Recordings from variant lines of PC12 cells, which selectively express either rBII/IIA or rPN1 channel subtypes, verified that the differential block by PIIIA also applied to native sodium current. The sensitivity to block by PIIIA toxin was then used to discriminate between rBII/IIA and rPN1 sodium currents in NGF-treated PC12 cells in which both mRNAs are induced. During the first 24 hr of NGF-treatment, PN1 sodium channels accounted for over 90% of the sodium current. However, over the ensuing 48 hr period, a sharp rise in the proportion of rBII/IIA sodium current occurred, confirming the idea, based on previous mRNA measurements, that two distinct sodium channel types appear sequentially during neuronal differentiation of PC12 cells.
|
2022-12-20T13:21:44.614Z
|
12,759,851 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.11547/ciqs2001.tokusi.0.JP24.0",
"MAG": "2610092150",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We present an approach for building protein backbones from alpha-carbon (Calpha) coordinates. The approach is analytical and based on the information of favored regions in the Ramachandran map. The backbone construction consists of three parts: prediction of (phi, psi) angle pairs from the Calpha trace, generation of atomic coordinates with these (phi, psi) angles, and refinement by subsequent energy minimization. Tests on several known protein structures show that the root mean square deviations in reconstructed backbones are 0.25-0.48 A for coordinates and 14-34 degrees for phi and psi angles. The results indicate that our method is one of the best methods proposed in terms of accuracy. It has also been revealed that the approach is not only robust against errors in Calpha coordinates but is also capable of providing equivalent or more reasonable models compared to other known methods. Furthermore, backbone structures were found to be built accurately by using the (phi, psi) angles from a different structure of the same protein. This suggests that the approach could be effective and useful in homology modeling studies.
|
2022-12-13T01:49:25.431Z
|
13,314,169 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/TMECH.2016.2612262",
"MAG": "2521368317",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
To study the effect of food flow rheology on the human esophageal swallowing process, a biologically inspired actuator prototype has been developed. The actuator is made of silicone rubber where smooth and continuous peristaltic motion is generated by inflating air chambers distributed within its body. The soft material gives the actuator intrinsic compliance and infinite degrees of freedom in motion. Thus, it is challenging to model the behavior online by current methods. In order to investigate the large-scale deformation of the soft-bodied actuator in response to the air chamber pressures, a geometrically simplified two-dimensional (2-D) model composed of separated beam-shaped elements is proposed. It considers the mechanical properties of the material, the sophisticated geometry of the actuator as it deforms, and the distributed pressure behavior. Empirical data from the actuator prototype (captured by articulography) and the simulated results are compared to investigate the accuracy of the model. The differences of deformations between the experimental results and the theoretical model are analyzed.
|
2022-12-17T22:01:20.425Z
|
2,638,271 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/hmg/ddx081",
"MAG": "2593324531",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://academic.oup.com/hmg/article-pdf/26/10/1801/14088400/ddx081.pdf"
}
|
&NA; Infantile myofibromatosis is one of the most prevalent soft tissue tumors of infancy and childhood. Multifocal nodules with visceral lesions are associated with a poor prognosis. A few familial cases have been linked to mutations in various genes including PDGFRB. In this study, we sequenced PDGFRB, which encodes a receptor tyrosine kinase, in 16 cases of myofibromatosis or solitary myofibroma. Mutations in the coding sequence of PDGFRB were identified in 6 out of 8 patients with the sporadic multicentric form of the disease and in 1 out of 8 patients with isolated myofibroma. Two patients had the same mutation in multiple separated lesions. By contrast, a third patient had three different PDGFRB mutations in the three nodules analyzed. Mutations were located in the transmembrane, juxtamembrane and kinase domains of the receptor. We showed that these mutations activated receptor signaling in the absence of ligand and transformed fibroblasts. In one case, a weakly‐activating germline variant was associated with a stronger somatic mutation, suggesting a two‐hit model for familial myofibromatosis. Furthermore, the mutant receptors were sensitive to the tyrosine kinase inhibitor imatinib, except D850V, which was inhibited by dasatinib and ponatinib, suggesting a targeted therapy for severe myofibromatosis. In conclusion, we identified gain‐of‐function PDGFRB mutations in the majority of multifocal infantile myofibromatosis cases, shedding light on the mechanism of disease development, which is reminiscent of multifocal venous malformations induced by TIE2 mutations. Our results provide a genetic test to facilitate diagnosis, and preclinical data for development of molecular therapies.
|
2022-12-18T05:00:33.189Z
|
219,408,574 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1097/01.GOX.0000667284.82196.52",
"MAG": "3025720020",
"PubMedCentral": "7224727"
},
"license": null,
"status": null,
"url": null
}
|
Methods: A single-center retrospective cohort study was performed to analyze all consecutive patients undergoing immediate implant-based breast reconstruction following mastectomy over two years (2015-2016). The authors reviewed the incidence of postoperative hematomas amongst all patients who either did, or who did not receive intravenous TXA at the time of surgery. The patients in the intervention group received 1000 mg of intravenous TXA prior to incision and 1000 mg at the conclusion of the procedure. Demographic and surgical characteristics were collected for all patients. The primary outcome measure was hematoma. Additionally, adverse events, such as thromboembolic occurrences were captured. Logistic regression analysis was performed using Fisher’s exact test and the Mann-Whitney-Wilcoxon test. Results with a p value of <0.05 were considered significant.
|
2022-12-19T05:35:38.117Z
|
255,148,714 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.56448/ataddergi.1181349",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Geçmişte denizlerdeki güç mücadelesi deniz kuvvetlerinin önemini artırmıştır. Bu mücadelede güçlü bir donanma uluslar için önemli bir itibar kaynağı olmuştur. Devletler donanma kurmak için kendi kaynaklarının yanında toplumsal kampanyalarla mali külfeti paylaşma yoluna gitmiştir. Bu bağlamda hem halk nezdinde denizcilik bilincini geliştirmek hem de kampanyaları yönlendirmek için Donanma cemiyetleri bir sivil toplum kuruluşu olarak hayat bulmuştur. Osmanlı Devleti’nde de donanmasızlık nedeniyle yaşanan toprak ve itibar kayıplarının yarattığı güdüyle 1909’da Donanma Cemiyeti kurulmuştur. Ardılı Türkiye Cumhuriyeti’nde akim kalan girişimlerin ardından 1965’te Donanma Cemiyeti Kıbrıs Krizinin sonrasında kurulmuş; donanmanın güçlendirilmesine önemli katkıda bulunmuştur. 1972’de Vakfa dönüşen oluşum, müşterek bir çatı altına girdiği 1987’ye kadar çeşitli kampanyalar yürütmüş, en önemlisi denizcilik bilincinin gelişmesine önemli katkıda bulunmuş, milli savunma sanayinin kurulmasını tetiklemiştir. Bu makalede, Donanma Cemiyetini tekrar ihya etme çabaları yanında, kurulduktan sonra yürüttüğü faaliyetler kendi yayını olan Derya dergisi, dönemin tanıklarının anıları ile diğer açık kaynaklar kullanılarak mercek altına alınmıştır.
|
2022-12-27T20:29:27.762Z
|
40,182,683 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3109/10428194.2012.708930",
"MAG": "2098043416",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Th e translocation t(8;14)(q24;q11) has been described at the cytogenetic and molecular level in pediatric cases of T-cell leukemia/lymphoma [1]. Although infrequent, the cases reported show a very aggressive clinical behavior with a poor response to standard acute lymphoblastic leukemia (ALL) chemotherapy and high risk of relapse [2]. We report a 4-year-old female with this entity, to document successful therapy focused on the use of fractionated alkylating agents, high-dose cytarabine and high-dose methotrexate. Th is approach was taken because initial ALL therapy was less than successful, and because the case had features reminiscent of Burkitt leukemia/lymphoma with an aggressive leukemic presentation, but a mature lymphoid phenotype and MYC rearrangement. After the patient achieved remission with this approach, she was treated with an allogeneic stem cell transplant and has remained in remission for more than 2 years. Th e patient was referred to the University of Chicago Center for Childhood Cancer and Blood Diseases with marked leukocytosis, anemia and thrombocytopenia. Symptoms started 1 week earlier with fevers, fatigue and poor oral intake. Treatment for a presumed acute otitis media did not improve symptoms. On admission, the patient demonstrated marked pallor and hepatosplenomegaly, but no lymphadenopathy. Th e initial complete blood count (CBC) was signifi cant for a hemoglobin (Hgb) of 7.7 g/dL, platelets of 60 10 9 / μ L and white blood cell (WBC) count of 672 10 9 / μ L. A peripheral blood smear showed mostly malignant lymphoid cells which resembled lymphoblasts with intermediate-sized nuclei, moderately fi ne chromatin, variable nucleoli, but with moderate amounts of agranular cytoplasm (Figure 1). Initial serum chemistry showed a creatinine of 0.7 mg/dL, blood urea nitrogen (BUN) 11 mg/dL, lactate dehydro genase (LDH) 3310 U/L (normal, 116 – 245 U/L), uric acid of 11.8 mg/dL (normal, 2 – 7.5 mg/dL) and normal potassium, calcium and phosphorus levels. Th ere was no mediastinal mass on chest radiography. Aggressive hydration and rasburicase reduced and maintained uric acid levels within the normal range. Th e overall cellularity of the bone marrow (BM) biopsy was markedly increased, with the majority of cells being similar to those in the blood. Flow cytometry demonstrated the following immunophenotype: bright CD45 , surface CD3 , CD2 , CD5 , CD7 , but absence of CD4 and CD8. Th e cells were α / β negative, but γ / δ positive. Th e malignant clone did not express terminal deoxynucleotidyl transferase (TdT), CD34, CD1a or coexpression of CD4 and CD8. Immunohistochemistry confi rmed the absence of TdT and demonstrated reactivity for the cytotoxic markers perforin, granzyme B and TIA1. Immunostaining also demonstrated MYC expression (in 100% of cells). In situ hybridization for Epstein – Barr virus (EBV) encoded RNA (EBER) was negative. On cytogenetic studies, there were two related abnormal clones: 47,XX,t(8;14)(q24.1;q11.2), 17[17]/46,idem, 9,i(9) (q10)[3], characterized by t(8;14)(q24;q11) involving the MYC gene at 8q24 and the T-cell receptor ( TCR ) α / δ gene at 14q11 (Figure 1, insert). Fluorescence in situ hybridization (FISH) analysis was positive for a MYC rearrangement in 75% of analyzed cells. Th ere were blasts present in the cerebrospinal fl uid, but with 5/ μ L WBCs (CNS2 status). Th ese fi ndings were felt to be consistent with T-cell leukemia/lymphoma, γ / δ -type, with MYC – TCR rearrangement. Th e patient was started on typical pediatric induction chemotherapy for high-risk ALL, which consisted of vincristine, dexamethasone, daunorubicin, PEG-asparaginase and intrathecal methotrexate. In the fi rst week of treatment, the WBC count declined to 100 10 9 / μ L, and the patient developed tumor lysis syndrome that responded well to medical management. During week 3 of induction, however, the patient had a persistent leukocytosis (15 – 20 10 9 / μ L), with 70% malignant cells in the peripheral blood. Treatment was altered to a clofarabine-based regimen including L eu k L ym ph om a D ow nl oa de d fr om in fo rm ah ea lth ca re .c om b y K ai na n U ni ve rs ity o n 04 /2 8/ 15
|
2022-02-12T04:42:11.850Z
|
101,268,217 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1248/CPB.31.2669",
"MAG": "2312392554",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
2-Methylenehexahydrocyclobuta[c]quinoline 2 obtained from cyclobuta[c]quinolinespiro-oxetanone 1 was isomerized to 2-methyltetrahydrocyclobuta[c]quinoline 5 by treatment with sodium ethoxide in dry toluene. The reaction of compound 5 with olefins, such as methyl acrylate, acrylonitrile, N-phenylmaleimide, and methyl methacrylate under reflux in dry xylene gave [4+2] cycloadducts, hexahydrophenanthridine derivatives 6-9. Ethoxycarbonylmethyl-cyclobuta[c]quinolines 4 generated by ethanolysis of 1 were treated with thionyl chloride in pyridine to give dehydrated products, (E)-2-(ethoxycarbonylmethylene)cyclobuta[c]quino-line (E)-13 and its isomer (Z)-13. Compounds (E)-13 and (Z)-13 isomerized to the same product, 2-(ethoxycarbonylmethyl)cyclobuta[c]quinoline 14 in the presence of sodium ethoxide in dry benzene at room temperature. Similarly, compound 14 reacted with olefins to give hexahydrophenanthridine derivatives 15-18 via a 2-oxoquinoline-3, 4-diquinomethane intermediate.
|
2022-08-28T01:54:52.939Z
|
11,295,937 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2991/eusflat.2013.2",
"MAG": "2115730570",
"PubMedCentral": null
},
"license": "CCBYNC",
"status": "GOLD",
"url": "https://download.atlantis-press.com/article/8364.pdf"
}
|
As an application of the dual equivalence between the category of L-spatial C-objects and the category of L-sober C-M-L-spaces, it is shown in this paper that for a fixed augmented partially ordered set A, there exists a dual equivalence between the category of A-spatial augmented partially ordered sets and the category of A-sober A-valued spaces. Then, with regard to this duality, for a fixed (Z1, Z2)complete partially ordered set L, we establish a dual equivalence between the category of L-spatial (Z1, Z2)-complete partially ordered sets and the category of L-sober L-valued Q-spaces.
|
2022-09-10T11:49:47.459Z
|
146,462,891 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S1389135900000374",
"MAG": "2166282866",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
On 26 March 1999, the Diplomatic Conference on the Second Protocol to the 1954 Hague Convention for the Protection of Cultural Property in the Event of Armed Conflict (hereinafter, 1954 Convention), held in The Hague from 15 to 26 March 1999, adopted a Second Protocol to that Convention. The reasons leading to the elaboration and adoption of the Second Protocol to the 1954 Hague Convention for the Protection of Cultural Property in the Event of Armed Conflict (hereinafter, Second Protocol) are manifold. Firstly, armed conflicts that have taken place since the entry into force of the 1954 Convention, such as in Cambodia, the Middle East or the former Yugoslavia, have revealed its deficiencies. In particular, the Convention lacked full application, as most of the armed conflicts have been of a non-international character; furthermore, it lacked proper implementation, as the system of execution of the Convention, which is based on a functioning Protecting Power-and Commissioner General-system, proved to be unworkable in practice; and, finally, it lacked adequate provisions to cope with the extensive and systematic destruction of cultural property during armed conflict, as it contains no mandatory criminal sanctions regime.
|
2022-09-13T22:28:28.779Z
|
37,111,775 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3892/OR.9.3.661",
"MAG": "2062995596",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The purpose of the study was to evaluate the effectiveness in terms of response rates, toxicity and survival of the combination chemotherapy regimen cisplatin and epidoxorubicin (epirubicin) including medroxyprogesterone acetate (MPA), recombinant IL-2 (rIL-2) and antioxidants in patients with advanced (stage IIIB-IV) non-small cell lung cancer (NSCLC). Thirty-three chemotherapy-naive patients with NSCLC were enrolled in the study and 30 of them were evaluable. The mean age of the patients was 61 years. Twenty (66.7%) out of 30 patients were >or=60 years, and 5 (16.7%) patients were >or=70 years. The ECOG performance status was 0 to 1 in 30 patients and 2 in 3 patients. Twenty-six patients (78.8%) had stage IIIB disease and 7 (21.2%) had stage IV; histology was mainly squamous cell carcinoma (72.7%). The treatment consisted of cisplatin 40 mg/m2/week and epirubicin 40 mg/m2/week both intravenously on day 1, rIL-2 1.8 MIU/day subcutaneously, MPA 1 g/day orally, alpha-lipoic acid 300 mg/day orally and N-acetyl cysteine 1.8 g/day orally. The treatment was administered for 6 weeks. Patients with a complete response (CR), partial response (PR) or stable disease (SD) continued the treatment, according to response re-evaluation, until 15 weeks. The present study reports the results of 6, 9, 12 and 15-week treatment. After 6 weeks, 30 patients were assessable for response: no CR was observed, a PR was achieved in 15 patients (50%; ORR 50%). After 15 weeks, 1 CR and 8 PR were observed (ORR 30.0%). The median follow-up period was 13 months. The median duration of response was 9 months. The median overall survival (OS) was 15 months. The one-year survival rate was 55.8%. The median progression-free survival (PFS) was 10 months. The toxicity was, as expected, mainly hematologic: neutropenia was the most significant symptom. The non-hematologic toxicity was quite low. Therefore, the treatment's toxicity was quite acceptable. There was no toxic death. The 30.0% ORR, the 15 month OS and the 10 month PFS obtained in this study are comparable with those observed with cisplatin plus epirubicin (ORR 39-54%) in phase II studies and in a previous phase III study (ORR 33%, OS 10.5 months). Moreover, the toxicity was acceptable and it was mainly hematologic. Serum levels of proinflammatory cytokines significantly decreased after treatment.
|
2022-12-17T23:36:26.908Z
|
216,168,595 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1079/9781789241273.0193",
"MAG": "3012064628",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://hal.inrae.fr/hal-02569293/document"
}
|
HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Nutrition and Feeding Strategy : Impacts on Health Status Thierry Gidenne, François Lebas, Dominique Licois, Jose I. Garcia
|
2022-12-30T00:23:45.997Z
|
57,362,166 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.15605/jafes.032.02.12",
"MAG": "2761868774",
"PubMedCentral": "7784230"
},
"license": "CCBYNC",
"status": "GOLD",
"url": "https://doi.org/10.15605/jafes.032.02.12"
}
|
Acromegaly is a rare disease with an annual incidence of 3 to 4 cases in a million.1 Diagnosis is often delayed due to the slow progression of the disease. Persistent elevation of growth hormone (GH) in acromegaly causes a reduction in life expectancy by 10 years. Aside from multiple cardiovascular, respiratory and metabolic co-morbidities, it has also been proven to cause an increased incidence of cancer. The main treatment of acromegaly is surgical excision of the functioning pituitary adenoma. Multiple comorbidities, including obstructive sleep apnea (OSA), left ventricular hypertrophy (LVH) and soft tissue swelling, make surgery complicated, if not impossible. Medical therapy to reduce comorbidities may be indicated in certain situations. Somatostatin receptor ligands (SRL) are able to reduce, and possibly normalize, IGF-1 levels.2 Reduction of insulin-like growth factor-1 (IGF-1), the main mediator of GH, is able to resolve headache, sweating, fatigue and soft tissue swelling, and also reduce ventricular hypertrophy. This case report illustrates the successful use of the SRL octreotide LAR in treating acromegaly. It also confirms the observation from several case series that thyroid cancer is the most common malignancy in acromegaly.
|
2022-02-03T08:10:20.321Z
|
75,167,215 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/1363849021000020768",
"MAG": "2334658568",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The paper by Sir Crisp English, reproduced here by kind permission of Mr Veryan Herbert and the Lancet, was the ®rst of three abstracts of his Hunterian lectures to the Royal College of Surgeons in 1904. The work is remarkable because of the author’s knowledge of head injury and its consequences. There are many references to the e ects of head injury in childhood throughout the three lectures, but I have chosen the ®rst one because of English’s particular reference to the question of age and recovery, the so-called Kennard Principle [1] or the question `Is it really better to have your brain lesion early? . . .’ [2]. English considered age among the main conditions in ̄uencing progress after head injury. He draws attention ([3], p. 487) to the dichotomy of opinion regarding age and recovery that has persisted to date [4, 5]: `It is usually stated that children recover remarkably well from injuries to the head, but my experience has not borne out this statement . . .’. One may speculate to what extent he may have been aware of earlier reports of age-related di erences in response to brain damage [6, 7]. However, it is evident that English was fully aware of the need to adopt a developmental perspective on the consequences of head injury [8]. English quali®ed in medicine in 1900 and in 1902 was awarded the Jacksonian Prize for an essay on head injury. Unfortunately, it seems that English’s work in this area was interrupted by public interest in a lower organ, the appendix, and subsequently he became preeminent in that branch of medicine. There is perhaps more than a little irony in that transition, in view of his opening remarks ([3], p. 485), `The rapid and almost startling advance of abdominal surgery during recent years has exerted a retarding in ̄uence upon other branches of surgery, it has overshadowed cerebral surgery . . .’. It seems that abdominal surgeons may have been two-a-guinea, as it were, whilst there was just a handful of neurological specialists. Given his astute observations and thinking on head injuries, it is likely that clinical and experimental neuroscience today would be far more advanced than it is if English had chosen to remain one of the few. In the late 19 th and early 20 th centuries, the common mechanisms of head injury would have been very similar. The literature contains references to children being run over by cartwheels or thrown from dogcarts, for example, as well as the usual assaults and falls. Consequently, the general pathology is likely to have been very similar, particularly deceleration insult to the prone frontal and temporal lobes, but without the high velocity acceleration injury caused by modern vehicular accidents. Acute medical and surgical care has advanced in recent times, such that we now have a greater number of survivors and consequently higher morbidity. Attempts at measuring outcome may seem to be more sophisticated now, but it is likely that return to work or education have remained the main classi®cations since English’s time. One invariant factor is the biological make-up of the immature brain [9, 10]. The vulnerability of immature structures to the e ects of insult will have been as great then as now. Aberrant development of the brain after early insult would have been the same, whatever the time or cause, with perhaps greater awareness of the behavioural sequelae [11]. It follows that the prevalence of disability, handicap and associated needs caused by head injury in children should be correspondingly greater now than 100 years ago. The consequences of head injury have always been detrimental to the individual’s functioning. Then, as now, the bene®cial e ects resulting from head injuries were considered almost entirely con®ned to the imaginations of novelists. However, there are rare examples where brain damage has the paradoxical e ect of
|
2022-02-11T07:32:46.773Z
|
130,767,207 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2208/PROHE.50.841",
"MAG": "2329270001",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The collapse of a permeable dam mainly due to overflows has been investigated with experiments and numerical studies. In order to numerically predict this process, the treatment of fluid forces acting on permeable materials is essentially important. In contrast to the previous numerical methods, 3D MICS, a computational method for incompressible multiphase fields, allows us to deal with the movement of solid bodies included in free-surface flows without any empirical formulations, such as a resistance coefficient, Cd. The validity of 3D MICS is discussed through the comparison with the experimental results.
|
2022-02-09T14:04:14.140Z
|
42,068,370 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1001/JAMA.1993.03510140051021",
"MAG": "1992350324",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
To the Editor. —The study by Fleming et al 1 is of limited relevance to current prostate cancer management and fails to demonstrate that watchful waiting is as effective as active treatment in men over the age of 65 years. Moreover, it may impart misleading information for treating individual patients. Fleming et al based their estimates of cancer progression rates on a patient population that overrepresented patients most likely to die of other causes, such as elderly men with stage A disease, and underrepresented younger patients with more aggressive tumors. This introduced a bias in favor of watchful waiting. The historical data used for estimates of treatment outcomes do not accurately reflect the current ability to detect prostate cancer early and to treat it effectively. Recent studies have demonstrated a dramatic increase in the detection of early, curable prostate cancer through screening with serum prostate-specific antigen (PSA) measurements. 2,3 Fleming
|
2022-09-14T14:53:34.665Z
|
93,925,263 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1039/C5RA12159K",
"MAG": "1899394258",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This work offers a methodology for screening compatible buffer conditions for both DNA origami and protein crystallisation and studied how protein crystallisation buffer conditions notably cations, buffering agents, precipitants, and pH, influenced the stability of tubular DNA origami.
|
2022-12-11T03:38:59.187Z
|
28,827,773 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1097/TA.0000000000000946",
"MAG": "2441831075",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
BACKGROUND Because of its uncommon nature and a lack of comprehensive literature, abdominal wall hernias caused by blunt trauma continue to present a management dilemma. This study was performed to identify the incidence of associated injuries, the need for urgent operative intervention, and recurrence rates after hernia repair. METHODS A retrospective review of patients diagnosed with a traumatic abdominal wall hernia from January 2002 to December 2014 was performed. Data were collected from the trauma registry and included patient demographics, location and type of hernia, associated injuries, operative interventions, complications, and length of stay. RESULTS Eighty patients (64% male; median age, 36 years; mean Injury Severity Score [ISS], 22) were identified during the study period. A motor vehicle collision was the most frequent mechanism of injury (n = 58). Overall, 35 patients (44%) underwent urgent laparotomy or laparoscopy, and 10 of these (29%) were nontherapeutic excluding hernia repair. Of interest, 17 patients (49%) required bowel resection. Notably, the need for operative intervention and nontherapeutic rate differed depending on hernia location. Hernia repair was performed in 23 patients, the majority of whom (78.3%) underwent repair within 5 days of injury. There were six recurrences, four of which were repaired acutely (within 1 week of injury), with an overall first-time hernia recurrence rate of 26%. CONCLUSION In the largest series to date, traumatic abdominal wall hernias were found to be associated with a high percentage of intra-abdominal injuries requiring urgent laparotomy or laparoscopy. Rates of therapeutic interventions varied by hernia location, with anterior abdominal hernias associated with the highest need for a therapeutic operation. Acute repair was associated with the majority of the recurrences. LEVEL OF EVIDENCE Epidemiologic study, level III; therapeutic study, level IV.
|
2022-12-12T12:18:29.933Z
|
20,971,026 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1097/00000441-200008000-00012",
"MAG": "2085050326",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
V complications of diabetes are a major cause of morbidity and mortality worldwide. Good control of glycemia has been shown to be an effective way of delaying the onset and retarding the progression of these complications. The exact pathogenesis of these complications is not known. It is likely that many different and diverse factors play some part. The role of growth hormone (GH) will be the focus of attention in this article. The hypersecretion of GH in some diabetic states is well known. In cases in which the excess GH secretion is not accompanied by GH resistance, the peripheral organs may be exposed high levels of systemic IGF-1 which in turn, may contribute to the development of micro and macrovascular complications of diabetes.
|
2022-12-17T01:33:30.496Z
|
1,376,797 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/CONIEL.2005.21",
"MAG": "1514976202",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Various methods for estimating the radiation pattern of an antenna in 3D have been assessed with antenna measurements conducted at different angles in azimuth and elevation for two different in-building antenna types. The use of one of these methods for real coverage predictions is then analysed, as, for practical cellular designs, antenna manufacturers only provide two orthogonal cuts.
|
2022-09-01T02:50:02.932Z
|
120,115,745 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICIPRM.2003.1205335",
"MAG": "1760804206",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
InGaAlAs/GaAsSb/InP Double HBTs with micrometer emitter size were designed, processed and characterized with DC, microwave and power performance for the first time. In addition to the advantages of using type-II band line-up at base-collector junction, the DHBT structure results in small turn-on voltage and ballistic launching of electrons due to the positive conduction band discontinuity from the emitter to base. Fabricated large DHBTs showed high DC gain (>80), small turn-on voltage of 0.62V, almost zero offset voltage, and nearly ideal base and collector current characteristics. Small DHBTs demonstrated V/sub CEO/ >8V and stable operation at high current density exceeding 100kA/cm/sup 2/. Maximum f/sub T/ of 57GHz and maximum f/sub max/ of 66GHz were achieved from 1/spl times/20/spl mu/m/sup 2/ device at J/sub C/ = 8.0/spl times/10/sup 4/ A/cm/sup 2/ and V/sub CE/ =3.5V. Preliminary power measurement of 2/spl times/15/spl mu/m/sup 2/ device showed a linear gain of 10dB and compressed output power of 5dBm at 5GHz.
|
2022-09-15T00:02:48.610Z
|
145,749,716 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4314/sajpem.v26i4.31490",
"MAG": "2085290171",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://philpapers.org/archive/METTMF.pdf"
}
|
Abstract Here I introduce the symposium issue of the South African Journal of Philosophy that is devoted to critically analysing my article “Toward an African Moral Theory.” In that article, I use the techniques of analytic moral philosophy to articulate and defend a moral theory that both is grounded on the values of peoples living in sub-Saharan Africa and differs from what is influential in contemporary Western ethics. Here, I not only present a précis of the article, but also provide a sketch of why I have undertaken the sort of project begun there, what I hope it will help to achieve, and how the contributors to the symposium principally question it.
|
2022-12-16T08:37:24.568Z
|
236,521,645 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/UR52253.2021.9494694",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Most of the recent studies of reinforcement learning and robotics basically employ computer simulation due to the advantages of time and cost. For this reason, users have to spare time for investigation in order to choose optimal environment for their purposes. This paper presents a survey result that can be a guidance in user’s choice for simulation environments. The investigation result includes features, brief historical backgrounds, license policies and formats for robot and object description of the eight most popular environments in robot RL studies. We also propose a quantitative evaluation method for those simulation environments considering the features and a pragmatic point of view.
|
2022-12-17T09:45:34.894Z
|
34,125,816 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1440-1754.1997.tb01611.x",
"MAG": "2011450961",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Objective: To evaluate the effects of intravenous midazolam on haemodynamic variables and cerebral blood flow velocity (CBFV) and to determine the pharmacokinetics using a population approach in very low birthweight (VLBW) ventilated infants.
|
2022-12-17T13:32:55.970Z
|
29,490,183 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1107/S160057671700560X",
"MAG": "2616964052",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
CrystalWalk is a crystal editor and visualization software designed for teaching materials science and engineering. Based on WebGL/HTML5, it provides an accessible and interactive platform to students and teachers by introducing a simplified crystallographic approach that creates crystal structures by combining a lattice with a motif without the use of its internal symmetry. CrystalWalk is the first software to use solely translational symmetry, aiming to introduce engineering students to the basic concepts of lattice and motif. Although very restrictive from the crystallographic point of view, CrystalWalk makes it simple for students to experiment, reproduce and visualize, in an interactive manner, most of the crystal structures that are commonly introduced in materials science and engineering curricula.
|
2022-12-22T15:13:35.373Z
|
228,100,658 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/acs.orglett.0c03868",
"MAG": "3111683479",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Re2O7 in hexafluoroisopropyl alcohol provides access to cationic intermediates from alcohols through the intermediacy of perrhenate esters. This manuscript describes the application of the system to the formation of a number of weakly basic heterocyclic systems through dehydration reactions and intramolecular nucleophilic addition. The influence of the substrate structure on the reaction rates and stereocontrol is discussed with respect to intermediate ion pairs.
|
2022-12-25T22:55:59.016Z
|
110,927,635 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/CCDC.2012.6242997",
"MAG": "2144388572",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Pressure measurement has always been an important part of aircraft wind tunnel tests. The traditional method of pressure measurement uses the model with a series of special pressure taps on its surface to get discontinuous pressure data. Recently, Pressure Sensitive Paint (PSP) technology which uses optical method for measuring pressure distribution of the surface of the specific area has attracted much attention as an effective approach for pressure measurement. This paper introduces the basic theory of the Pressure Sensitive Paint (PSP) measurement technology and the development of control system for the experiments. The analysis of the experiments data provides the credible evidence for the farther popularization of the Pressure Sensitive Paint (PSP) measurement technology.
|
2022-07-09T02:06:06.352Z
|
201,902,090 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.11591/IJPEDS.V10.I4.PP1932-1943",
"MAG": "2969037602",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Unified Power Quality Conditioner (UPQC) is substantial power conditioner in power system to filter the power system parameters with an objective to improve the quality of power delivered to the customers/utility point. This paper presents a multi-level UPQC to enhance the quality in power distribution system. The series and shunt controllers of UPQC gives out five leveled output which is further filtered to feed compensating signals to improve voltage and current profiles in power distribution system. Series and shunt controllers of UPQC are structured with cascaded H-Bridge (CHB) topology to deliver compensating signals. Two separate control strategies are employed to regulate the power switches of 5-level CHB series and shunt controllers of UPQC. Sag and swell in source voltage and harmonics in source current are strained with UPQC. The proposed system is developed and results are obtained using MATLAB/SIMULINK software.
|
2022-10-05T15:42:06.355Z
|
120,905,149 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1029/94JA00142",
"MAG": "2000252825",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The Rice convection model has been modified for application to the transport of Io-generated plasma through the Jovian magnetosphere. The new code, called the RCM-J, has been used for several ideal-MHD numerical simulations to study how interchange instability causes an initially assumed torus configuration to break up. In simulations that start from a realistic torus configuration but include no energetic particles, the torus disintegrates too quickly (∼50 hours). By adding an impounding distribution of energetic particles to suppress the interchange instability, reasonable lifetimes were obtained. For cases in which impoundment is insufficient to produce ideal-MHD stability, the torus breaks up predominantly into long fingers, unless the initial condition strongly favors some other geometrical form. If the initial torus has more mass on one side of the planet than the other, fingers form predominantly on the heavy side (which we associate with the active sector). Coriolis force bends the fingers to lag corotation. The simulation results are consistent with the idea that the fingers are formed with a longitudinal thickness that is roughly equal to the latitudinal distance over which the invariant density declines at the outer edges of the initial torus. Our calculations give an average longitudinal distance between plasma fingers of about 15°, which corresponds to 20 to 30 minutes of rotation of the torus. We point to some Voyager and Ulysses data that are consistent with this scale of torus longitudinal irregularity.
|
2022-12-25T15:45:11.804Z
|
168,035,916 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.13031/2013.29765",
"MAG": "2035371010",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Providing a dry, comfortable resting area for dairy cattle is essential to their health, well being and performance. Properly designed, constructed and maintained freestalls (cubicles) are an essential component in a system that meets these requirements.
|
2022-10-25T17:52:46.908Z
|
134,091,003 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.26874/KJIF.V2I2.29",
"MAG": "2736668712",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Demensia merupakan istilah pada penyakit yang berkaitan dengan penurunan fungsi memori. Memori merupakan proses penyimpanan dan pengambilan kembali informasi melalui sinyal-sinyal saraf di otak oleh senyawa asetilkolin (Ach). Senyawa ACh menjadi tidak aktif oleh aktivitas enzim asetilkolinesterase (AChE). Aktivitas AChE yang tinggi dapat menggambarkan terjadinya demensia. Senyawa yang dapat menghambat aktivitas AChE dapat menggambarkan potensi sebagai obat anti demensia. Tanaman yang berpotensi mengandung senyawa tersebut adalah kunyit (Curcuma longa Linn). Penelitian ini bertujuan untuk mengetahui potensi minyak atsiri rimpang kunyit (Curcuma longa Linn) dalam menghambat aktivitas AChE pada tikus model demensia yang diinduksi trimetiltin (TMT).Minyak atsiri diperoleh dari hasil destilasi menggunakan metode destilasi uap air kemudia dianalisis komponen senyawa yang terkandung menggunakan metode GC-MS. Uji penghambatan aktivitas AChE dilakukan pada tikus Sprague dawley jantan umur ±2 bulan. Hewan uji dibagi dalam 6 kelompok. Kelompok I, II, III (normal, kontrot dan citicoline) dan kelompok IV, V, VI (diberi minyak atsiri dosis 100, 200, dan 400 mg/kg BB). Perlakuan dilakukan selama 29 hari. Pemberian TMT i.p dosis 8 mg/kg BB dilakukan pada hari ke-8 kecuali kelompok normal. Otak tikus diambil dan dipreparasi hingga diperoleh supernatan. Penetapan aktivitas AChE menggunakan reagen kit (katalog #K764-100). Analisis data menggunakan ANOVA dengan Post Hoc LSD. Komponen utama pada minyak atsiri rimpang kunyit hasil analisi GC-MS yaitu ar-tumerone (49,47%), alpha tumerone (19,91%), dan alpha phellandrene (4,24%). Hasil uji penghambatan aktivitas AChE pada kelompok kontrol berbeda tidak bermakna (P>0.05) dibandingkan kelompok normal. Penurunan aktivitas AChE kelompok pemberian citicoline berbeda bermakna (p<0.05) terhadap kelompok kontrol. Penurunan aktivitas AChE otak pada kelompok MARK dosis 200 mg/kgBB dan 400 mg/kgBB berbeda bermakna (p<0.05) dibandingkan kelompok kontrol namun berbeda tidak bermakna pada dosis 100 mg/kgBB. Pemberian minyak atsiri rimpang kunyit mulai dosis 200 mg/kg BB dapat menghambat aktivitas enzim AChE pada tikus model demensia yang diinduksi TMT.
|
2022-11-11T07:49:27.625Z
|
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