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255M
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144,521,959 |
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One problem that faces special education teachers of young handicapped students is choosing among interventions. There has been an increased awareness recently of the issue of level of intrusiveness, or a concern for choosing the least‐restrictive intervention. Certainly the least intrusive, but effective, intervention is the one to choose. But given a level of intrusiveness, how does one choose among interventions? It is the purpose of this paper to discuss considerations for choosing an intervention based upon aspects of the student, the situation, and the intervention itself.
|
2022-02-09T06:55:26Z
|
40,195,316 |
{
"externalids": {
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"DOI": "10.1111/j.1749-6632.1984.tb12322.x",
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|
The understanding of the catalytic mechanism of enzyme action requires the synthesis of diverse types of information, such as kinetic characterization, crystal structure determination, and the effects of metal-ion replacement, coenzyme analogue substitutions, and chemical modification of various active-site residues. In addition, chemical modification for amino acid sequence determination is a prerequisite for many of these types of studies. It is thus inconceivable that an understanding of the mechanism of action of any enzyme can be achieved without extensive modification of its structure. Nevertheless, there is often considerable apprehension about the study of the catalytic activity of active-site modified enzymes and about the relevance of such studies to the understanding of the unmodified forms. The basis for such caution is usually the extreme sensitivity of catalytic activity and kinetics to very small structural perturbations or charge alterations. Consequently, the interpretation of observed changes in catalytic activity and kinetics in terms of specific alterations in the active-site structure requires much supporting evidence. Such endeavors are quite essential, however, since not all proposed mechanisms for the unmodified enzymes can rationalize the observed consequences of the active-site modifications. The study of covalently and specifically modified enzyme forms can thus be regarded as an attempt to produce by design a set of pseudoisozymes whose comparative study may lead to useful structure-function correlations similar to those often sought in the comparative study of naturally occumng isozymes or structurally homologous enzymes that show distinct kinetic differences.
|
2022-09-10T01:53:46.029Z
|
214,053,844 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.20884/1.JAP.2019.21.1.710",
"MAG": "3004527757",
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|
This research was aimed to investigate heritability score (h 2 ) of milk yield, kid birth weight, and milk quality that included density, fat content, protein, lactose, water and non-fat dry matter of Saanen goat according to the production record of first-lactating individual in the Centre of Pedigree Breeding and Cattle Forage Baturraden. The materials for this research were 180 Saanen does with a first-lactating record. The estimated genetic parameter was heritability score using a paternal half-sib correlation method. Result showed that the heritability of milk yield, kid birth weight, density, fat content, protein, lactose, water and NFDM was 0,32 + 0,23; 0,25 + 0,26; 0,15 + 0,17; 0,11 + 0,16; 0,12 + 0,16; 0,10 + 0,14; 0,10 + 0,16 and 0,11 + 0,16, respectively. A high h 2 was obtained from heritability score of milk yield, and a moderate h 2 was from kid birth weight and milk quality. In conclusion, the h 2 score of milk yield of Saanen goats was relatively high, while the h 2 score of kid birth weight and milk quality was relatively moderate.
|
2022-09-17T18:26:52.813Z
|
84,863,947 |
{
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"ArXiv": null,
"DOI": "10.3109/10915818909019550",
"MAG": "2048963964",
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"status": "CLOSED",
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|
A wide variety of compounds was examined for the ability to induce a specific form of hepatic cytochrome P450 and to promote the development of DEN-initiated liver tumors (adenomas and carcinomas) in rats over a 72 week period. The induction of cytochrome P450b was determined indirectly by measuring the hepatic induction of pentoxy-or benzyloxyresorufin O-dealkylase activities, which are highly specific substrates for the major phenobarbital-inducible forms of cytochrome P450 in the rat.(10) Results in the rat showed: (1) potent inducers (> 40 ×) of P450b (i.e., phenobarbital, barbital, ethylphenyl-hydantoin, and DDT) are all potent liver tumor promoters; (2) structural analogs that are not inducers of P450b (i.e., hexobarbital, monoethylbarbituric acid, monophenyl-barbituric acid, and diethylhydantoin) all fail to display significant liver tumor promoting activity; and (3) the concomitant induction of liver hypertrophy, microsomal epoxide hydrolase, and cytochrome P450b appears to be proportional and argues for some coordinated “pleiotropic” response of liver parenchyma to these inducers. Additional studies showed that phenobarbital induced cytochrome P450b and was a liver tumor promoter not only in rats, but also in mice and patas monkeys, but was inactive as an enzyme inducer and was a nonpromoter in the hamster.
|
2022-12-08T22:44:04.508Z
|
88,700,471 |
{
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"ArXiv": null,
"DOI": "10.1080/14634988.2016.1169686",
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|
Hamilton Harbour was identified by the International Joint Commission as a problem area in 1978 and later identified as an Area of Concern in 1985. In response to its Remedial Action Plan, the harbour has been systematically monitored since 1987. In this study, we present the long-term water quality record (1987 to 2012) of Hamilton Harbour, focusing on the parameters and seasonal intervals of particular importance to the Remedial Action Plan beneficial use impairments. The long-term summer records showed that total phosphorus concentrations decreased in the first decade and have remained relatively unchanged since 1998, while an increasing trend in Secchi disc depth was observed until 2005 only to be reversed since then. No significant changes in chlorophyll a concentrations have been observed since 1987 despite significant changes in total phosphorus. Hypoxia in the hypolimnion of Hamilton Harbour remains a common occurrence and despite long-term trend improvements there has been little change over the last decade. Spring conditions have also changed, and higher conductivity values and chlorophyll a concentrations have been measured in recent years. A strong correlation between spring hypolimnetic dissolved organic carbon concentrations and dissolved oxygen depletion rates was found suggesting the organic material load to the harbour is an important controlling factor for hypoxia. Finally, the data suggest that the hypolimnetic accumulation rate of soluble reactive phosphorus in the summer has increased since 1987, most notably since the early 2000s. However, it is only since 2008 that this translated into an increasing trend in hypolimnetic soluble reactive phosphorus concentrations. These data suggest that conditions have recently changed in Hamilton Harbour and that sediment phosphorus release may delay water quality improvements for many years following reductions in total phosphorus loadings. Further research is needed to understand the implications to the Remedial Action Plan water quality goals.
|
2022-11-06T18:04:56.411Z
|
110,381,236 |
{
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"ArXiv": null,
"DOI": "10.1068/b4103c",
"MAG": "2099979071",
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},
"license": "CCBYNC",
"status": "HYBRID",
"url": "https://doi.org/10.1068/b4103c"
}
|
This paper ended an initial period of wide enthusiasm in attempting to realise the potential
of computer innovations to revolutionise urban planning (Harris, 1960). It was an era when
both the planning and the computer domains were strongly influenced by strong positivist
ideas about the nature of scientific progress. Planning was mainly a comprehensive�rational,
linear but also cyclical process in which experts examined all possible (or politically defined)
problems and relevant solutions, which in turn would lead to optimal decisions (Faludi,
1973). Even then this was extensively questioned in academic research that emphasised the
limits of human cognitive capacity: that is, information processing (Simon, 1969).
|
2022-12-02T05:27:14.101Z
|
216,366,612 |
{
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"DOI": "10.32640/tasj.2020.1.52",
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"status": "BRONZE",
"url": "https://442d5d6d-43f0-43f2-b27b-2c332b37e62f.filesusr.com/ugd/c16819_7a8b106e5c004e50b584798345f31356.pdf"
}
|
Ventricular Assist Devices are blood pumps used in patients with Congestive Heart Failure who are waiting for a heart transplant. They aim to assist the ventricle to pump out blood in physiological circulation by increasing aortic pressure and decreasing intraventricular pressure. The IFSP Laboratory of Bioengineering and Biomaterials (BIOENG) has been developing an Implantable Centrifugal Blood Pump called CARoL for mechanical circulatory support. The objective of this dissertation is to evaluate the changes in the crystallinity of the polymeric Pivot Bearings supporting the impeller of this pump when subjected to friction generated by rotation of zirconia oxide ceramic shafts. The adopted methodology consisted of submitting new and used samples of: a) bearings set made of polyamide 6; and b) the set made of poly-ether-ether-ketone. Those new and used samples were characterized by X-ray diffraction tests and Infrared Spectroscopy. The diffractograms and spectra obtained were compared to evaluate the bearing crystallinity, for both polymers before and after friction. The tests carried out showed diffractograms and similar spectra for the new and used samples, thus, there are indications that the friction generated by the rotation of the shafts did not change the crystallinity of the polymeric bearings supporting the pump rotor.
|
2022-12-12T22:52:19.586Z
|
245,677,403 |
{
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"ArXiv": null,
"DOI": "10.2307/276919",
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|
In a brief report, which was read before the 8th Conference for Plains Archeology by George Metcalf, 1 attempted to reconstruct the procedure by which the carcass of an antelope was prepared for food. The inferences thus drawn were based upon the ratio of the various elements to each other and to the greatest number of individuals represented, as well as the location of the breaks or cuts in the bones. Since the antelope is one of the smaller food animals and could be moved to a convenient butchering place, the question immediately posed itself: “How would size affect the butchering technique since a bison must necessatily be butchered where it is killed?“ The bison bone which provides the basis for this study was collected during the excavation of two archaeological sites near Pierre, South Dakota. The Dodd site was a multi-component village, but there was evidence of only a single cultural complex at the Phillips Ranch site (Lehmer, 1952).
|
2022-12-17T09:21:16.560Z
|
209,602,639 |
{
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"DOI": "10.1590/1678-5150-pvb-6214",
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"license": "CCBYNC",
"status": "GOLD",
"url": "http://www.scielo.br/j/pvb/a/JLVLfTRwFswVN9tC8MM6GCj/?lang=en&format=pdf"
}
|
ABSTRACT: The objective of this study was to evaluate the hepatoprotective effect of the honey bee Apis mellifera ethanolic extract of the red propolis, obtained in four municipalities of the Rio Grande do Norte semi-arid region, through an in vitro evaluation of the antineoplastic potential in human hepatic carcinoma (HepG2) and normal cell lines (L929), and from the comet assay in hepatic cell lines (ZF-L hepatocytes) to evaluate the genoprotective potential of the extract. The hepatoprotective effect was also evaluated in vivo by the induction of chronic experimental hepatic lesions in rodents (Rattus norvegicus Berkenhout, 1769), Wistar line, by intraperitoneal administration of thioacetamide (TAA) at the dose of 0.2g/kg. The animals were distributed in the following experimental groups: G1 (control), G2 (treated with 500mg/kg ethanolic extract of propolis), G3 (treated with 500mg/kg of ethanolic extract and TAA) and G4 (treated with TAA). All rats were submitted to serum biochemical, macroscopic, histological and stereological biochemical exams of the liver. It was verified the genoprotective effect of red propolis since the mean damages promoted to DNA in cells tested with the extract were significantly lower than the mean of the positive control damage (hydrogen peroxide). The red propolis extract did not present cytotoxic activity to the tumor cells of human liver cancer, as well as to normal ones. The absence of cytotoxicity in normal cells may indicate safety in the use of the propolis extract. The results of the serum biochemical evaluation showed that the serum levels of the aminotransferase enzymes (AST) did not differ significantly between G1, G2 and G3 when compared to each other. G4 showed significant increase in levels compared to the other groups, indicating that the administration of the extract did not cause liver toxicity, as well as exerted hepatoprotective effect against the hepatic damage induced by TAA. The G3 and G4 animals developed cirrhosis, but in G3 the livers were characterized by the presence of small regenerative nodules and level with the surface of the organ, whereas in G4 the livers showed large regenerative nodules. The livers of the G1 and G2 animals presented normal histological appearance, whereas the livers of the G3 animals showed regenerative nodules surrounded by thin septa of connective tissue, and in G4 the regenerative nodules were surrounded by thick septa fibrous connective tissue. The analysis of the hepatic tissues by means of stereology showed that there was no statistical difference between the percentage of hepatocytes, sinusoids, and collagens in G1 and G2. In G3 the percentage of hepatocytes, sinusoids, and collagen did not differ significantly from the other groups. It was concluded that the ethanolic extract of the red propolis exerted a hepatoprotective effect, because it promoted in vitro reduction of the damage to the DNA of liver cells, antineoplastic activity in human hepatocellular carcinoma cell line (HepG2) and did not exert cytotoxic effect in normal cells or was able to reduce liver enzyme activity and the severity of cirrhosis induced by TAA in vivo.
|
2022-12-24T08:40:49.356Z
|
3,540,786 |
{
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"ArXiv": null,
"DOI": "10.1109/ROBOT.2010.5509669",
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|
This paper describes a hierarchical planner deployed on a mobile manipulation system. The main idea is a two-level hierarchy combining a global planner which provides rough guidance to a local planner. We place a premium on fast response, so the global planner achieves speed by using a very rough approximation of the robot kinematics, and the local planner begins execution of the next action even without considering subsequent actions in detail, instead relying on the guidance of the global planner. The system exhibits few planning delays, and yet is surprisingly effective at planning collision free motions. The system is deployed on HERB [20], combining a Segway mobile platform, a WAM arm, and a Barrett hand. The navigation and manipulation components have been tested on the real robot, and the task of simultaneously approaching and grasping a bottle on a countertop was demonstrated in simulation.
|
2022-12-28T20:39:28.394Z
|
976,146 |
{
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"DOI": "10.1097/01.AOG.0000241092.79282.87",
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|
OBJECTIVE: To review systematically the evidence about maternal and infant outcomes of cesarean delivery on maternal request and planned vaginal delivery. DATA SOURCES: We searched MEDLINE, Cochrane Collaboration resources, and Embase and identified 1,406 articles through dual review using a priori inclusion criteria. METHODS OF STUDY SELECTION: We included English language studies published from 1990 to June 2005 that compared the key reference group (cesarean delivery on maternal request or proxies) and planned vaginal delivery. TABULATION, INTEGRATION, AND RESULTS: We identified 54 articles for maternal and infant outcomes. Virtually no studies exist on cesarean delivery on maternal request, so the knowledge base rests on indirect evidence from proxies with unique and significant limitations. Most studies compared outcomes by actual routes of delivery, resulting in variable relevance to planned routes of delivery. Primary cesarean delivery on maternal request and planned vaginal delivery likely differ with respect to individual outcomes; for instance, risks of urinary incontinence and maternal hemorrhage were lower with planned cesarean, whereas the risk of neonatal respiratory morbidity was higher and maternal length of stay was longer with planned cesarean delivery. However, our comprehensive assessment, across many outcomes, suggests no major differences between primary cesarean delivery on maternal request and planned vaginal delivery, but the evidence is too weak to conclude definitively that differences are completely absent. If a woman chooses to have a cesarean delivery in her first delivery, she is more likely to have subsequent deliveries by cesarean. With increasing numbers of cesarean delivery, risks occur with increasing frequency. CONCLUSION: The evidence is significantly limited by its minimal relevance to primary cesarean delivery on maternal request. Future research requires developing consensus about terminology, creating a minimum data set for cesarean delivery on maternal request, improving study design and statistical analyses, attending to major outcomes and their special measurement issues, assessing both short- and long-term outcomes with better measurement strategies, dealing better with confounders, and considering the value or utility of different outcomes.
|
2022-12-29T17:31:43.425Z
|
229,310,233 |
{
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"DOI": "10.1109/ASEMD49065.2020.9276350",
"MAG": "3113142591",
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"url": null
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|
The magnet system of 14 $T$ magnetic resonance imaging (MRI) is under design at Institute of Plasma Physics Chinses Academy of Sciences (ASIPP), Hefei, China. In the latest design, the maximum magnetic induction field of the magnet system is 14.3 T. High performance Nb3Sn strand is the best candidate superconducting material to build such high field magnet device. To meet the requirement, ASIPP and Western Superconducting Technologies Company (WST) are cooperating to develop high performance Nb3Sn strand, the critical current density Jc is higher than 2000A/mm2 at 4.2 K, 12 T. To study WST high performance Nb3Sn strand, the critical current Ic or quench current was measured at different field using the voltage-current (V-I) method. Besides, the residual resistivity ratio (RRR) were also measured. Furthermore, a small coil was designed and fabricated to study the strand whether it will be affected by low field instability. The preliminary investigation is presented and discussed in here.
|
2022-02-07T22:59:00.249Z
|
134,248,454 |
{
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"ArXiv": null,
"DOI": "10.1080/01916122.2018.1518849",
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|
ABSTRACT Terrestrial palynomorphs from the siliciclastic rocks of the Hørbyebreen and Mumien formations in the Birger Johnsonfjellet area, Spitsbergen are documented, providing new knowledge of the stratigraphical ranges of the recorded taxa. Together with a reassessment of previous palynological work in the light of recent advances in palynology, the definitions of three informal palynological assemblages are established. These are correlated to the Carboniferous miospore biozones of Western Europe but differences in the stratigraphical ranges are recorded, as Spitsbergen is located in a different paleofloristic province. Paucity of palynological data from the Arctic areas, as well as lack of independent age control, hampers exact age assignment of the palynological assemblages described. Two age alternatives of the lower part of the Hoelbreen Member are discussed, with the most plausible age for the studied section being mid to late Visean in age. A more consistent and up-to-date correlation of the Mississippian palynofloras in the Arctic region is provided, demonstrating similarities to other Arctic regions. The new age reassessment also improves knowledge of stratigraphical breaks in the succession, providing better understanding of the tectono-stratigraphical history of the region.
|
2022-09-03T07:29:08.942Z
|
206,447,012 |
{
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"ArXiv": null,
"DOI": "10.1109/49.926359",
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},
"license": null,
"status": "CLOSED",
"url": null
}
|
This paper describes a hybrid image rejection receiver. The hybrid image rejection receiver contains a modified Hartley (1928) image rejection mixer and a digital image rejection processor. The modified Hartley image rejection mixer performs similarly to an original Hartley image rejection receiver but provides two digital outputs. In one output it enhances the desired signal and in the other output it enhances the image signal. The digital image rejection processor first measures the mismatching effect in the analog devices and then suppresses the image signal by compensating for the mismatching effect. We also propose a simplified implementation method for the hybrid image rejection receiver to reduce its computation complexity. Computer simulation was used to evaluate the performance of this simplified implementation method to include the quantization effect introduced by the A/D converters. Simulation results show that the proposed hybrid image rejection receiver achieves much better performance than the original Hartley image rejection receiver. This architecture greatly relaxes the matching requirements of the analog devices and has a low complexity for an IC implementation.
|
2022-09-14T05:47:57.576Z
|
32,606,407 |
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"DOI": "10.1177/039139888200500309",
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|
A pneumatic, wearable, batter-powered TAH-drive unit is presented. This drive-unit is characterized by a very good overall efficiency, achieved by design optimization on one hand and controlled economized membrane displacement on the other. The implemented control system facilitates an adoption to circulatory needs. The integrated micro-computer controls the whole pumping cycle and calculates the effective blood-side stroke volume by a beat to beat analysis of drive-side parameters. It could be demonstrated in animal tests (calves) under varying loads that the available driving power is sufficient to maintain an adequate circulatory supply for calves up to 135 kg. Further, it could be demonstrated that a sufficient right/left balance was obtained over the whole animal test duration.
|
2022-09-15T00:55:25.009Z
|
247,872,931 |
{
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"ArXiv": null,
"DOI": "10.3390/atmos13040561",
"MAG": null,
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},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2073-4433/13/4/561/pdf?version=1649239552"
}
|
Inefficient residential solid fuel combustion contributes significantly to ambient and indoor air pollutants. It consumes large quantities of fuel and produces harmful effects on health. Improvements in residential biomass cooking stoves have great potential for energy savings and emission reduction. This study presents an advanced biomass gasifier cooking stove to overcome the disadvantages of high-pollutant emissions from widely used stoves in China. The most innovative features of the stove are (1) negative pressure produced by a jet fan located at the junction of the chimney, and (2) combustion and carbonization processes taking place in the same chamber. Compared with a traditional chimney stove, the advanced biomass gasifier cooking stove presented higher TE (thermal efficiency) and comprehensively lower pollutant emissions when raw crop straws, crop straw briquettes, and pellets were burned in it. Approximately 40% CO2 and 90% of PM2.5 (the aerodynamic diameter was less than or equal to 2.5 μm) EFs (emission factors) were eliminated, and TE drastically tripled. Furthermore, biomass briquette/pellet was identified as more suitable than raw biomass as a fuel to be burned in the new stove, especially because the raw biomass displayed an increase in the EFs of As, Se, and Pb when burned in the new stove. The advancement in biomass cooking stove technology is a practical approach to reducing the emissions of CO2, PM2.5, and other hazardous pollutants.
|
2022-09-16T00:38:32.079Z
|
54,682,801 |
{
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"DOI": "10.1088/1757-899X/355/1/012014",
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"status": null,
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|
With the induction heating technology, it is possible to heat up blanks for the press hardening process in 20 s or less. Furthermore, the dimension of an induction system is small and easy to control in comparison to conventional heating systems. To bring the induction heating technology to warm forming industry it is necessary to analyze the process under the view of induction. This paper investigates the edge- and end-effects of a batch heated blank. The results facilitate the later design of induction heating systems for the batch process.
|
2022-10-21T01:07:38.204Z
|
244,609,124 |
{
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"DOI": "10.17853/1994-5639-2021-8-84-110",
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},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.edscience.ru/jour/article/download/2395/1036"
}
|
Introduction. The process of professional training in most economic sectors is now thoroughly developed and regulated by global science. Today, the exception is the creative directions of professional activity, which play an important role in society. Therefore, there is a reasonable request for the professional training in creative industries. However, in science and practice, it is still not clear how professional training in creative industries should be carried out. An educational model, based on modern approaches and principles of learning, can be an effective solution to this problem.Aim. The present research aimed to disclose the content and results of approbation of the model of professional training in computer-based music production.Methodology and research methods. The research methodological framework is based on the concepts of competency-based, activity-based, technological and personality-oriented approaches to education; research papers on the problems of using computer music technologies in education; theory and practice of teaching models application in higher education.The leading method was the modelling of the educational process in specialised training in the field of computer-based music production. An experimental research study was carried out with the participation of students and teachers of higher education (n = 83 people). The authors employed the following methods: a questionnaire survey, testing, practical assignments, measurement of motivation for educational computer-based music production, the Fisher’s method.Results and scientific novelty. The current research paper presents the authors’ model of specialised computer-based musical instruction, which includes four main units: motivational-targeted, content-logical, activity-technological and diagnostic (evaluative-productive). The novelty of the model is determined by the implementation of the leading innovative educational activity of students, which is characterised by the production, processing and reproduction of musical material using musical computer technologies. An important component of the model is a complex of pedagogical technologies, which is a part of the activity-technological unit and includes the following technologies: interactive, design, research, modelling technologies, individualisation of training, computer and information technologies. The effectiveness of the content of the proposed educational model is confirmed by the results of the experimental research study on the implementation of this model in the conditions of student mastery of computer-based music production disciplines in the real educational process of a pedagogical university. The data obtained revealed a high (sufficient and advanced) level of formation of computer-based musical competencies among students.Practical significance. The model for specialist training can become a separate element of the educational programme, which provides training for specialists in computer-based music production. The research materials may have implications for the further development of educational science and the practice of specialist training in other creative industries.
|
2022-02-07T20:09:09.664Z
|
204,015,098 |
{
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"DOI": "10.7907/8ZM9-6671.",
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|
New 350 micron data constrain accurately the thermal far-infrared spectral energy distributions (SEDs) for 12 distant submillimeter selected galaxies (SMGs). The results confirm that the linear radio to far-infrared correlation, established for local infrared galaxies, holds out to high redshifts z ~ 1--3. The low correlation constant q ~ 2.14 is more indicative of star formation than AGN-fueled dust heating. The sample exhibits an apparent luminosity--temperature relation (L_FIR ~ T_d^2.89), possibly owing to selection effects. As a result, photometric redshifts in the radio or far-infrared may not be viable, but expressions may relate the observed quantities for current flux and volume limited SMG samples. These suggest that SED estimation may be possible, for objects similarly selected, based on a single radio or far-infrared flux measurement.
The detection of these faint objects (~10 mJy at 350 micron) from the ground is complicated by a bright (~1000 Jy) and highly variable (~10 Jy RMS in 10 minutes of integration) atmosphere with a 1/f^2 noise spectrum and by instrumental 1/f noise. To reach optimum sensitivities, a careful analysis of the data is required, and well-chosen observing strategies are helpful. The principal techniques that aid the extraction of weak signals from colored noise are presented. Close to optimal analysis is implemented effectively by the CRUSH software. Both the computing and storage requirement of the implementation scales linearly with the size of the data set, making this approach superior to the computationally expensive alternatives for handling the very large data volumes expected from future instruments.
|
2022-12-01T14:34:59.806Z
|
236,965,928 |
{
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"ArXiv": "2108.04379",
"DOI": "10.1080/00029890.2022.2011569",
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"license": null,
"status": "GREEN",
"url": "http://arxiv.org/pdf/2108.04379"
}
|
Abstract We give a short proof of a recently established Hardy-type inequality due to Keller, Pinchover, and Pogorzelski together with its optimality. Moreover, we identify the remainder term which makes it into an identity.
|
2022-12-15T04:01:45.563Z
|
117,053,283 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2151/JMSJ1965.69.6_687",
"MAG": "196973331",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Two datasets of monthly-mean wind stress, estimated from Ships-of-Opportunity data covering the North Pacific (O*-50*N) and the Pacific trade wind region (30*S-30*N), are used to describe the spatial character of interannual variability. Two characteristic time scales related to the occurrence of ENSO events are given by period bands around 3.6 years (EN) and 2 years (QB), being associated with spectral peaks found in sea surface temperature (SST) in the eastern equatorial Pacific area. Spatial features of wind stress variations in the two period bands are described by patterns derived from correlations between SST in the area and the zonal and meridional components of the wind stress in the datasets. The variation in the EN-band around 3.6 years is coherent over a large portion of the study areas covering the extratropics as well as the tropics and has a Pacific-basin scale. The wind stress pattern in the maximum phase of the SST corresponding to the peak phase of an El Nino event has not only symmetric features, such as westerly anomalies near the equator, but also asymmetric features such as easterly anomalies covering the western porion north of the equator. These spatial features are similar to those in composite fields for the peak phase of El Nino events, which suggests that the EN-period variation is a principal element in ENSO variability. On the other hand, the variation in the QB-band around 2 years is dominant in the tropical area, especially in the western portion north of the equator, being incoherent over most of the study areas. It is suggested that the QB-period variation is characteristic of the tropical zone covering the Indian Ocean and that its phase relationship with the EN-period variation is important for the occurrence of ENSO events.
|
2022-12-17T22:44:52.622Z
|
246,426,073 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/nu14030588",
"MAG": null,
"PubMedCentral": "8839073"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2072-6643/14/3/588/pdf?version=1644285862"
}
|
The number of people living with dementia globally is increasing rapidly, and there is no effective therapy. Dietary pattern is one important risk factor for the development and progression of dementia. We undertake this study to determine whether Taiwanese vegetarian diet in midlife affects dementia incidence in later years in a prospective cohort. We followed 5710 participants (average age less than 60) in the Tzu Chi Vegetarian Study (TCVS). We started recruiting in 2005 and followed until the end of 2014 when the database changed from ICD-9-CM to ICD-10-CM codes. The incidence of dementia was obtained through linkage to the National Health Insurance Research Database. We used Cox proportional hazards regression to estimate the hazard ratio of dementia between vegetarians and nonvegetarians. There were 121 cases of dementia (37 vegetarians and 84 nonvegetarians) diagnosed. Vegetarians were associated with reduced risk of clinically overt dementia compared with nonvegetarians (hazard ratio = 0.671, confidence interval: 0.452–0.996, p < 0.05) after adjusting for gender, age, smoking, drinking, education level, marriage, regular exercise, and comorbidities with stepwise regression.
|
2022-12-19T06:30:43.986Z
|
89,694,198 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/1365-2745.12907",
"MAG": "2767560723",
"PubMedCentral": null
},
"license": "CCBY",
"status": "HYBRID",
"url": "https://besjournals.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1365-2745.12907"
}
|
Plants leave species‐specific legacies in the soil they grow in that can represent changes in abiotic or biotic soil properties. It has been shown that such legacies can affect future plants that grow in the same soil (plant–soil feedback, PSF). Such processes have been studied in detail, but mostly on individual plants. Here, we study PSF effects at the community level and use a trait‐based approach both in the conditioning phase and in the feedback phase to study how 12 individual soil legacies influence six plant communities that differ in root size. We tested if (1) grassland perennial species with large root systems would leave a stronger legacy than those with small root systems, (2) grass species would leave a more positive soil legacy than forbs, and (3) communities with large root systems would be more responsive than small‐rooted communities. We also tested (4) whether a leaf‐chewing herbivore and a phloem feeder were affected by soil legacy effects in a community framework. Our study shows that the six different plant communities that we used respond differently to soil legacies of 12 different plant species and their functional groups. Species with large root systems did not leave stronger legacies than species with small root systems, nor were communities with large root systems more responsive than communities with root systems. Moreover, we show that when communities are affected by soil legacies, these effects carry over to the chewing herbivore Mamestra brassicae (Lepidoptera: Noctuidae) through induced behavioural changes resulting in better performance of a chewing herbivore on forb‐conditioned soils than on grass‐conditioned soils, whereas performance of the phloem feeder Rhopalosiphum padi (Hemiptera: Aphididae) remained unaffected. Synthesis. The results of this study shed light on the variability of soil effects found in previous work on feedbacks in communities. Our study suggests that the composition of plant communities determines to a large part the response to soil legacies. Furthermore, the responses to soil legacies of herbivores feeding on the plant communities that we observed, suggests that in natural ecosystems, the vegetation history may also have an influence on contemporary herbivore assemblages. This opens up exciting new areas in plant–insect research and can have important implications for insect pest management.
|
2022-12-26T19:22:03.789Z
|
27,662,204 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2217/nnm.11.187",
"MAG": "2110080779",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
AIM
The aim of this study was to investigate the impact of a novel nanoemulsion (NE) adjuvant, a soybean oil emulsion, on autoimmune response. To this end, we used murine thyroglobulin (mTg)-induced experimental autoimmune thyroiditis in mice as a study model.
MATERIALS & METHODS
Mice received NE or NE + mTg by nasal delivery. At 1 week after the second nasal delivery of NE with or without mTg, all mice were immunized with mTg and lipopolysaccharides to induce experimental autoimmune thyroiditis.
RESULTS
Compared with controls, mTg-NE-treated mice had much more antigens accumulated in the nasal passage and thymus and developed a milder form of thyroiditis. This was accompanied by an increase in IL-10, IL-17 and reduced IFN-γ. The production of anti-mTg antibodies was significantly decreased in mTg-NE-treated mice. The percentage of Tregs in cervical lymph nodes was higher in mTg-NE-treated mice than NE-treated mice. Furthermore, Foxp3 and TGF-β levels were prominently enhanced in mTg-NE-treated mice.
CONCLUSION
This study indicates that a low dose of mTg in NE can significantly enhance antigen uptake and Tregs, resulting in inhibition of experimental autoimmune thyroiditis development.
|
2022-12-31T15:58:44.842Z
|
245,839,659 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/jdv.17846",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Hyperpigmented spots are common issues in all ethnicities, involving multiple intrinsic and extrinsic factors such as UVB exposure, hormone balance, inflammatory status and ageing.
|
2022-12-24T14:31:12.288Z
|
103,059,310 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3406/SGEOL.1989.1832",
"MAG": "2808371969",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Solubility of uraninite (UO₂) in H20 and aqueous solutions (KCl + HCl ;HF ;Na₂CO₃ ; NaOH + Na₂C₂O₄) has been measured from 300° to 600 °С at P = 1 kbar. The fO₂ values were controlled by hematite-magnetite or nickel-nickel oxide buffers. The results obtained show that in the temperature range investigated UO₂ solubility in pure H₂O does not practically depend on temperature (and on the kind of buffer as well) and averages to 10(-9± 0 5) mol/kg H₂O. Uraninite solubility measured at 500 °C increases in Na₂CO₃, NaOH + Na₂C₂O₄, HF and more essentially in KCl + HCl solutions. The dependence of uranium migration capability in natural environment upon temperature and fluids composition is discussed.
|
2022-05-23T16:24:42.092Z
|
96,577,191 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1271/BBB1961.54.691",
"MAG": "2057492984",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The antibody binding sites (B-cell epitopes) on β-lactoglobulin (β-LG) were surveyed by assaying the reactivity of the tryptic fragments of β-LG to mouse anti-β-LG antiserum with ELISA. Four peptide fragments (the residues 21Ser-40Arg, 41Val-60Lys, 102Tyr-124Arg, and 149Leu-162Ile) bound the antibodies. We considered that B-cell epitopes of β-LG were included in these fragments. Furthermore, these four tryptic fragments were also reactive with the antiserum to RCM β-LG. Therefore, the unfolding of the β-LG molecule is considered not to influence the localization of the antibody binding sites on β-LG.
|
2022-07-08T05:58:10.510Z
|
109,395,430 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1115/OMAE2011-49946",
"MAG": "1969033519",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper and the companion paper (Rateiro et al., 2011) present an illustrative case of the joint application of experimental tests and numerical simulations for the proper analysis of a complex offshore operation (launching of a sub-sea equipment using one or two vessels). The main idea of the whole study is to compare two methodologies and operational procedures for the installation of the equipment in the seabed, using either one vessel (conventional operation) or two vessels in a synchronized operation in a Y-configuration. The experiment was conducted under a simplified configuration, and uses ODF (one degree of freedom) servo-actuator to emulate the vessels induced motion. The hydrodynamic properties of the equipment was then calculated, and some preliminary conclusions about system dynamics could also be drawn. After that, numerical simulations were conducted, considering the coupled dynamics of the vessels, cables and equipments under irregular sea state. Those simulations were used for determining the limiting environmental condition for a safe operation, and are described in the companion paper. This paper describes the reduced scale experimental setup used for evaluating the hydrodynamic properties of the equipment during a subsea installation under waves excitation. The reduced scale model of the equipment was attached to one or two servo-actuator, that emulate the wave-induced motion. The tests were conducted at the physical wave basin of Numerical Offshore Tank (Tanque de Provas Numerico – TPN). The experiments enabled the preliminary evaluation of the dynamic behavior of the equipment when submerged by one or two launching cables. In the later case (two launching cables), several tests considering phase shifts between the servo-actuator have been conducted. The reduction in the dynamic amplification of cable traction could also be experimentally verified.Copyright © 2011 by ASME
|
2022-09-01T00:02:29.881Z
|
70,489,174 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1600-0536.1992.tb05266.x",
"MAG": "1971661412",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Thiocolchicoside is a semisynthetic muscle relaxant obtained from colchicoside (colchico-glycoside) (1). Its chemical name is 2-demethoxy-2-glucosidoxythiocolchicine (Fig. 1). Thiocolchicoside has been used for many years orally, intramuscularly and intravenously as a decontractant and anti-inflammatory agent. It has clinical applications in neurology, orthopaedics, anaesthesiology and sports medicine. Thiocolchicoside is also used for endoarticular infiltration and has recently been used topically, because of its antioedematous and analgesic properties. It is usually well-tolerated both topically and systemically (2, 3), though some ill-defmed local intolerance has been mentioned (4). Patients sensitized to this substance after topical use should not be given it systemically, due to the risk of generalized eruptions. SHORTCOM~CATIONS
|
2022-09-13T03:30:57.147Z
|
40,909,160 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/tcr.201600041",
"MAG": "2474256609",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This account describes the work of our group in the selective catalytic reduction of nitrogen oxides (NOx ) with ammonia over heterogeneous photocatalysts (photo-SCR) in the past 16 years. We have found that the photo-SCR proceeds over heterogeneous photocatalysts using a gas flow reactor, elucidated the reaction mechanism under UV- and visible-light irradiation by spectroscopic and kinetic studies, and developed a highly active photo-SCR system by improving the photocatalyst material itself and the reaction system with several approaches based on the reaction mechanism.
|
2022-12-12T23:14:43.389Z
|
20,886,073 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/pcn.12218",
"MAG": "1533282189",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Previous studies consistently reported increased harm avoidance (HA) assessed with the Temperament and Character Inventory (TCI) in patients with major depressive disorder (MDD). However, such findings may have been related with depression severity and number of depressive episodes. The aims of the present study were twofold: to examine TCI personality profile in remitted MDD (DSM‐IV) patients and to compare TCI personality between MDD patients with single episode (SGL‐MDD) and those with recurrent episodes (REC‐MDD) in order to elucidate personality profile associated with recurrence.
|
2022-12-19T06:05:47.567Z
|
23,555,802 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/IJC.2910430202",
"MAG": "2030125357",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A hybridoma cell line secreting an IgM monoclonal antibody (MAb) was produced after immunizing a mouse with RT4 cells and a crude suspension of human bladder carcinoma cells (WHO grades II and III TCC). This MAb reacted with RT4 target cells derived from a human transitional bladder cancer but failed to react with a majority of non‐bladder cancer cell lines. Immunohistological studies indicate that this MAb reacts inconstantly with normal bladder: in positive cases only a few superficial cells (5% to 10% umbrella cells) are stained but not intermediate or basal cells of the urothelium. This MAb was evaluated on 118 tumors: it reacted with tumor tissue in a majority of grade 1 (79.5%) and grade II papillary TCC (77.3%), less with grade III papillary TCC (45%) and very rarely with invasive non‐papillary TCC (14%). In cases of flat lesions a strong reactivity of superficial, intermediate and/or basal layer cells was observed in 50% of moderate and severe dysplasia and in all cell layers of carcinomas in situ (CIS)(9/9).
|
2022-12-19T13:25:57.612Z
|
14,115,354 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.54294/l78zbl",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "HYBRID",
"url": "https://doi.org/10.54294/l78zbl"
}
|
Automatic tracking of coronary arteries in Computed Tomography Angiography (CTA) is a challenging task. To accomplish it we propose a method consisting of two main steps: (1) A 3D model of the heart is matched for detecting the approximate position of the heart. Based on this information candidates for origins of coronary arteries are calculated. (2) Fitting of cylindrical sampling patterns is performed for extracting the vessel tree of coronary arteries. Branching and termination are handled by depth-first search and noise level estimation respectively. Results show that – compared to human intra-observer variations – the presented method performs worse for accuracy measures (on average 39.4 scores), but slightly better for overlap measures (on average 51.5 scores).
|
2022-12-20T01:42:19.190Z
|
145,240,017 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/J.1460-2466.1998.TB02737.X",
"MAG": "2118076654",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This article examines the political, economic, historic, and cultural explanations for why the United States lags behind other major English-speaking countries in the formal delivery of media education. The research relies on formal documents and newsletters, interviews with leading media education researchers and teachers from numerous nations, and site visits to five countries. Among the many factors explored are the sheer physical size of the U.S., its highly heterogeneous population, resistance to the federal government’s making central educational or broadcasting policy, the fact that the U.S. exports far more media products than it imports, and a long-standing reluctance to take the popular arts seriously. * * * The United States finds itself in the ironic position of being the world’s leading exporter of media products while lagging behind every other major Eng1ish-speaking country in the world in the formal delivery of media education in its schools. Are there specific reasons that explain the less developed state of U.S. media education? If so, what obstacles lie ahead? The formal research for this study began in 1993 when I began collecting material from around the world, including formal documents, brochures, newsletters, and educational plans; interviewing leading media education scholars and researchers, as well as experienced media education master teachers and inexperienced teachers from around the world; and directly observing in five countries, spending the greatest periods in England, Scotland, and the United States. A worldwide movement in media literacy education has been growing for roughly 30 years. Since the mid-1990s, Australia has mandated media education from kindergarten through 12th grade. Ontario has mandated it for grades 7-12 since 1987. In Britain in 1996, approximately 25,000 students took their GCSE exams (for 16-year-olds) and some 8,000 university-bound 18-year-o1ds took their A Level (advanced level) exams in media studies. Even before the fall of apartheid, South Africa was already ahead of the United States in formal media education (Criticos, 1997). Numerous non-English-speaking regions and countries have also developed media education initiatives at a rapid rate. Substantive developments have occurred in Scandinavia, South America, Europe, Asia, Russia, and Israel (see Brown, 1991; Piette & Giroux, 1997). In the United States, significant statewide initiatives are now in place in New Mexico and North Carolina, with noteworthy developments having occurred in Wisconsin, Minnesota, and other states. Most states are home to one or more organized groups working to advance the cause of media education, locally, statewide, or nationally. In 1992, the first National Leadership Conference on
|
2022-12-31T14:50:46.639Z
|
7,523,373 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.7554/eLife.04034",
"MAG": "1967636553",
"PubMedCentral": "4270138"
},
"license": null,
"status": null,
"url": null
}
|
The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of 50 papers in the field of cancer biology published between 2010 and 2012. This Registered Report describes the proposed replication plan of key experiments from ‘Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion’ by Straussman and colleagues, published in Nature in 2012 (Straussman et al., 2012). The key experiments being replicated in this study are from Figure 2A, C, and D (and Supplemental Figure 11) and Figure 4C (and Supplemental Figure 19) (Straussman et al., 2012). Figure 2 demonstrates resistance to drug sensitivity conferred by co-culture with some stromal cell lines and identifies the secreted factor responsible as HGF. In Figure 4, Straussman and colleagues show that blocking the HGF receptor MET abrogates HGF’s rescue of drug sensitivity. The Reproducibility Project: Cancer Biology is a collaboration between the Center for Open Science and Science Exchange, and the results of the replications will be published by eLife. DOI: http://dx.doi.org/10.7554/eLife.04034.001
|
2022-08-16T00:58:44.540Z
|
72,486,565 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5468/KJOG.2012.55.2.137",
"MAG": "2064310403",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
137 A CASE OF TREATMENT BY EMBOLIZATION OF UTERINE ARTERIAL PSEUDOANEURYSM FOLLOWING LAPAROSCOPIC SUPRACERVICAL HYSTERECTOMY Mi-Ra Lee, MD, Min-Jeong Kim, MD, Hye-Ji Jeon, MD, Sl-A Choi, MD, Yun-Sook Kim, MD, Dong-Han Bae, MD, DongErk Goo, MD Departments of Obstetrics and Gynecology, Interventional Radiology, Soonchunhyang University Chunan Hospital, University of Soonchunhyang College of Medicine, Chunan, Korea
|
2022-08-28T22:56:07.757Z
|
43,332,125 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1024/1661-8157/a001212",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://www.zora.uzh.ch/id/eprint/91507/1/CME_2013_03_Meulengracht.pdf"
}
|
Bilirubin ist ein toxisches Stoffwechselprodukt des Häm-Metabolismus, welches in grossen Mengen durch den normalen Umsatz von Hämoglobin und anderen Hämoproteinen ensteht. Täglich werden 250 bis 300 mg Bilirubin produziert, 70-80 % entstehen aus dem Abbau alternder Erythrozyten [1,2]. Bilirubin ist wasserunlöslich und daher im Serum an Albumin gebunden. Im endoplasmatischen Retikulum der Hepatozyten wird Bilirubin durch Glukuronidierung metabolisiert. Das Enzym Glukuronyltransferase (UGT) überträgt ein Molekül Glukuronsäure von UDP-Glukuronsäure auf das Substrat. Durch diese Kopplung wird Bilirubin wasserlöslich und kann in die Gallenkanälchen sezerniert und so ausgeschieden werden. Kommt es zu einem Ungleichgewicht zwischen Produktion und Ausscheidung von Bilirubin, führt dies zu einer Serumbilirubinerhöhung. Bilirubin im Serum ist erhöht, wenn die Häm-Produktion die metabolische Kapazität von 4 mg/kg/die oder die Ausscheidung übersteigt [2]. Dies geschieht entweder durch eine zu hohe Abgabe von Bilirubin-Vorstufen in die Blutbahn oder durch eine eingeschränkte hepatische Aufnahme oder Exkretion.
|
2022-12-09T15:02:22.949Z
|
25,839,950 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1073/pnas.1522434113",
"MAG": "2291589681",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://www.pnas.org/content/pnas/113/11/2988.full.pdf"
}
|
Significance Understanding the evolution of the CNS is fundamental for resolving the phylogenetic relationships within Panarthropoda (Euarthropoda, Tardigrada, Onychophora). The ground pattern of the panarthropod CNS remains elusive, however, as there is uncertainty on which neurological characters can be regarded as ancestral among extant phyla. Here we describe the ventral nerve cord (VNC) in Chengjiangocaris kunmingensis, an early Cambrian euarthropod from South China. The VNC reveals extraordinary detail, including condensed ganglia and regularly spaced nerve roots that correspond topologically to the peripheral nerves of Priapulida and Onychophora. Our findings demonstrate the persistence of ancestral neurological features of Ecdysozoa in early euarthropods and help to reconstruct the VNC ground pattern in Panarthropoda. Panarthropods are typified by disparate grades of neurological organization reflecting a complex evolutionary history. The fossil record offers a unique opportunity to reconstruct early character evolution of the nervous system via exceptional preservation in extinct representatives. Here we describe the neurological architecture of the ventral nerve cord (VNC) in the upper-stem group euarthropod Chengjiangocaris kunmingensis from the early Cambrian Xiaoshiba Lagerstätte (South China). The VNC of C. kunmingensis comprises a homonymous series of condensed ganglia that extend throughout the body, each associated with a pair of biramous limbs. Submillimetric preservation reveals numerous segmental and intersegmental nerve roots emerging from both sides of the VNC, which correspond topologically to the peripheral nerves of extant Priapulida and Onychophora. The fuxianhuiid VNC indicates that ancestral neurological features of Ecdysozoa persisted into derived members of stem-group Euarthropoda but were later lost in crown-group representatives. These findings illuminate the VNC ground pattern in Panarthropoda and suggest the independent secondary loss of cycloneuralian-like neurological characters in Tardigrada and Euarthropoda.
|
2022-12-21T11:01:33.143Z
|
28,756,907 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4236/OJS.2014.49062",
"MAG": "2000103986",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Effects of many medical procedures appear after a time lag, when a significant change occurs in subjects’ failure rate. This paper focuses on the detection and estimation of such changes which is important for the evaluation and comparison of treatments and prediction of their effects. Unlike the classical change-point model, measurements may still be identically distributed, and the change point is a parameter of their common survival function. Some of the classical change-point detection techniques can still be used but the results are different. Contrary to the classical model, the maximum likelihood estimator of a change point appears consistent, even in presence of nuisance parameters. However, a more efficient procedure can be derived from Kaplan-Meier estimation of the survival function followed by the least-squares estimation of the change point. Strong consistency of these estimation schemes is proved. The finite-sample properties are examined by a Monte Carlo study. Proposed methods are applied to a recent clinical trial of the treatment program for strong drug dependence.
|
2022-12-29T14:46:56.210Z
|
1,598,395 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/EuCNC.2015.7194076",
"MAG": "1813449438",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The performance of YouTube in mobile networks is crucial to network operators, who try to find a trade-off between cost-efficient handling of the huge traffic amounts and high perceived end-user Quality of Experience (QoE). This paper introduces YoMoApp (YouTube Performance Monitoring Application), an Android application, which passively monitors key performance indicators (KPIs) of YouTube adaptive video streaming on end-user smartphones. The monitored KPIs (i.e., player state/events, buffer, and video quality level) can be used to analyze the QoE of mobile YouTube video sessions. YoMoApp is a valuable tool to assess the performance of mobile networks with respect to YouTube traffic, as well as to develop optimizations and QoE models for mobile HTTP adaptive streaming. We test YoMoApp through real subjective QoE tests showing that the tool is accurate to capture the experience of end-users watching YouTube on smartphones.
|
2022-12-31T18:33:58.115Z
|
79,478,964 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/ejhpharm-2017-000640.495",
"MAG": "2626620290",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Background Our centralised anticancer drug preparation unit is only open in the morning. Our annual production is 11 000 preparations for four different care units. Currently, chemotherapy infusions for afternoon patients are prepared in the morning and discarded if the administration is cancelled. To rationalise costs, the unit is considering the option of opening all day. Purpose This study estimated the profitability of opening the unit in the afternoon compared with the loss related to cancellations of the preparations produced in the morning for the afternoon. Material and methods The number of daily preparations, preparations dispensed in the afternoon and discarded preparations was recorded over a period of 3 months. The causes of the cancellations were listed. To determine the most profitable choice, we compared the cost of the discarded preparations (including active substance, packaging and the salary of the additional staff) and the cost of longer opening calculated on the basis of staff’s hourly rate. The costs of the preparation material (negligible) and the functioning costs of the unit (difficult to estimate) were not taken into account. Results Over the studied period, 3086 preparations were produced: 10% were intended to be administered in the afternoon. 3% of the afternoon preparations were not dispensed (n=10) versus 1% in the morning. 50% of the cancelled preparations planned in the afternoon were not reusable (n=5), causing a loss of €1674. 90% (n=9) of the cancellations came from the haematology service. The reasons for cancellation were unpredictable in 70% of cases (n=7). The average number of preparations planned in the afternoon was 4.8 (extremes (0; 15)). The cost of the required time to produce these preparations per afternoon over the studied period was €6712, 4 times the current losses. Conclusion The cost of all day opening is high because of staff requirements. Currently, it does not seem appropriate to extend opening hours. A return of the results of the study to the healthcare services is planned to raise awareness of predictable cancellations. No conflict of interest
|
2022-02-11T03:56:00.925Z
|
35,080,253 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/PHM.2016.7819920",
"MAG": "2579675362",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Random vibration test is common in mechanics engineering field, where the usually used typical spectrum is to general to truly reflect the vibration environment the products experience, while the methods used to describe the actual vibration based on measured signal, envelope method for example, is mostly qualitative with no statistical indicators to describe its accuracy. With the continuous improvement of random vibration test device, narrowband vibration is easy to achieve, which leads to demands of precisely described random vibration test. Based on statistics theory, the paper elaborates a quantitative method to make a vibration specification spectrum. By testing, merging, modeling and inducting the multi-channel, multi-band and multi-sub-sample data it is realized to quantitatively describe the random vibration environment in a certain confidence level.
|
2022-02-12T08:44:59.815Z
|
3,207,129 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/003591571400701718",
"MAG": "2404748380",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://journals.sagepub.com/doi/pdf/10.1177/003591571400701718"
}
|
focus the attention, it has become inconspicuous, so that the more natural and effective feature of the face, the real eye, catches and rivets the attention. One might sum up the effect in a line found in more than one of the early poets, " With one auspicious and one dropping eye." The out-looking, auspicious eye takes our gaze; the slightly drooping, winking eye is a companion inconspicuous by reason of its lesser character. Finally, the operation complete and the tissues healed, it is possible where glasses are ordinarily worn to give such a glass for the blind side as will make the palpebral fissure appear of equal vertical width with the natural side, and at the same time enlarge the upper lid so as to diminish still more the upper sulcus. A plus 3D. to 5D. cylinder, axis horizontal, will effect this. In the case of a man the wearing of a monocle on the natural side affords a good disguise to any inequality between the conditions of the eyes. But even without these accessories the effect of the operation is sufficient.
|
2022-02-13T12:54:17.126Z
|
221,180,575 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1097/PHH.0000000000001224",
"MAG": "3058509703",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
CONTEXT
After statewide legalization of recreational cannabis in California, the Los Angeles (LA) County Board of Supervisors requested a health equity impact assessment to inform its decisions on whether and how to regulate cannabis dispensaries in unincorporated areas of LA County.
OBJECTIVE
As part of this assessment, the LA County Department of Public Health compared the retail environments of licensed and unlicensed cannabis dispensaries in different parts of the county, using the Marijuana Retail Surveillance Tool (MRST), a validated instrument piloted in Colorado and Washington.
DESIGN
Two waves of observational surveys were conducted, one comparing licensed and unlicensed dispensaries within and near unincorporated areas of LA County and another comparing licensed dispensaries across LA County in areas with varying levels of health advantage according to a neighborhood index measuring social determinants of health.
MAIN OUTCOME MEASURES
Dispensaries were compared on measures of product types, promotional activities, security measures, regulatory compliance, and neighborhood context.
RESULTS
Unlicensed dispensaries were more likely than licensed dispensaries to sell products in packaging designed to be attractive to children (71.8% vs 10.8%, P < .001) and in non-child-resistant packaging (98.9% vs 15.6%, P < .001) and were more likely allow on-site consumption (60.9% vs 0%, P < .001). Licensed dispensaries showed high compliance with regulations, regardless of whether they were in areas of high or low health advantage.
CONCLUSIONS
The study points to the importance of efforts to eliminate illicit businesses as part of an overall strategy for regulating cannabis. It also demonstrates that the MRST is a flexible tool for regulatory surveillance and for continuing to study the relationships between cannabis retail environments and potential risks to public health.
|
2022-07-04T01:42:23.185Z
|
95,317,977 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/CM970803U",
"MAG": "2034255132",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The transition metal alkoxides Ti(OPri)4 and OV(OPri)3 are shown to catalyze the transesterification of tetramethyl- and tetraethyl orthosilicates: Si(OR)4 + R‘OH ↔ Si(OR)3(OR‘) + ROH. A detailed study of metal-catalyzed transesterification reactions and the factors that affect their efficiency and selectivity are presented. 29Si NMR techniques were used to quantify the extent of transesterification of the two different silicon alkoxides under a variety of conditions while mechanistic aspects of the reaction were probed using 51V NMR. It was found that tetramethyl and tetraethyl orthosilicates, when reacted with smaller, less sterically demanding alcohols, are substituted to a similar extent by both metals. However, transesterification of bulkier alcohols (2-propanol) revealed dramatic differences in their reactivity, with titanium being significantly more efficient than vanadium. The catalytic process and the differences in reactivity between the two metals are explained in terms of a mechanism involvin...
|
2022-09-13T01:38:06.284Z
|
10,482,612 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/15226514.2011.568548",
"MAG": "2809604065",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
An Egyptian national program targets annual reuse of 2.4 billion m3 of treated wastewater (TWW) to irrigate 84,000 ha of manmade forests in areas close to treatment plants and in the desert. To evaluate the feasibility of such afforestation efforts, we describe information about TWW irrigation strategies based on (1) water use of different tree species, (2) weather conditions in different climate zones of Egypt, (3) soil types and available irrigation systems, and (4) the requirement to avoid deep percolation losses that could lead to groundwater contamination. We conclude that drip irrigation systems are preferred, that they should in most cases use multiple emitters per tree in order to increase wetted area and decrease depth of water penetration, that deep rooting should be encouraged, and that in most situations irrigation system automation is desirable to achieve several small irrigations per day in order to avoid deep percolation losses. We describe directed research necessary to fill knowledge gaps about depth of rooting of different species in sandy Egyptian soils and environments, tree crop coefficients needed for rational irrigation scheduling, and depth of water penetration under different irrigation system designs. A companion paper addresses recommendations for afforestation strategies (see Zalesny et al. 2011, this issue).
|
2022-08-24T09:11:43.519Z
|
9,941,686 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1098/rspb.2009.0883",
"MAG": "2158300384",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc2842672?pdf=render"
}
|
A new well-preserved basal therapsid skull from the Xidagou Formation, Middle Permian of China, is identified as Biseridens qilianicus. The following synapomorphies distinguish Biseridens as an anomodont and not an eotitanosuchian as previously described: short snout; dorsally elevated zygomatic arch and septomaxilla lacking elongated posterodorsal process between nasal and maxilla. The presence of a differentiated tooth row; denticles on vomer, palatine and pterygoid; contact between tabular and opisthotic; lateral process of transverse flange of pterygoid free of posterior ramus and absence of mandibular foramen exclude it from other anomodonts. Our cladistic analysis indicates Biseridens to be the most basal anomodont, highlights separate Laurasian and Gondwanan basal anomodont clades and suggests that dicynodonts had their origins in the Gondwanan clade. The co-occurrence of the most basal anomodont (Biseridens) together with the most basal therapsid (Raranimus), basal anteosaurid dinocephalians, bolosaurids and dissorophids suggests that the earliest therapsid faunas are from China.
|
2022-12-13T12:58:03.495Z
|
235,475,486 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICIT46573.2021.9453515",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Single module of ZPUC topology is presented in this paper which can be operated with single DC source. Although ZPUC has one more capacitor compared to its counterpart PUC converter, it requires single DC source instead of three isolated DC sources in three-phase system which is a great advantages to reduce the cost and bulkiness of the system. It also reduces the total components counts of the converters in comparison to the most popular types of multilevel converters. Active voltage balancing through Phase shift pulsed width modulation (PS-PWM) strategy has been used to balance the voltages of three flying capacitors. ZPUC topology based on the 5-L inverter is investigated in Matlab-Simulink to validate the performance of the single module of ZPUC topology.
|
2022-12-17T02:13:54.033Z
|
26,392,785 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1006/BBRC.1996.1673",
"MAG": "1986715512",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The infectious prion protein (PrPSc) is the etiologic agent of transmissible neurodegenerative conditions such as scrapie or Creutzfeldt-Jakob disease. Its fragment 106-126 (PrP106-126) has been reported to maintain most of the pathological features of PrPSc. We report here the intracellular mechanisms mediating the proliferative effects of PrP106-126 on rat cortical type I astrocytes. The proliferative effects of PrP106-126 started after 24h of treatment and lasted up to 9 days and was antagonized by the L-type voltage-sensitive calcium channel blocker nicardipine. Microfluorimetric studies showed that PrP106-126 caused a rapid increase in the [Ca+2]i. This effect was prevented by nicardipine, or by Ca(+2)-free conditions, showing that the PrP106-126 enhances [Ca+2]i mobilizing Ca+2 from the extracellular environment. Moreover, binding studies demonstrated a direct interference of PrP106-126 with the dihydropyridine binding site. This is the first evidence that a prion protein fragment directly stimulates the proliferation of astrocytes via an increase in [Ca+2]i through the L-type voltage-sensitive calcium channels.
|
2022-12-18T16:18:44.528Z
|
43,735,392 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/jcu.22169",
"MAG": "1895366878",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The aim of this case series was to present the ultrasonographic findings, clinical features, management, and outcome of multiple pregnancies with complete hydatidiform mole and coexisting fetus (CHMCF).
|
2022-12-19T21:06:18.664Z
|
218,494,182 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/NMDC47361.2019.9084009",
"MAG": "3023323463",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this work, we investigate a wafer-scale, lithography-free, self-assembled indium phosphide (InP) nanopillars fabrication method based on ion bombardment. The influence of process conditions, such as the substrate temperature, ion beam energy, ion beam incidence angle, and processing time, were investigated with regard to the geometry (shape, diameter and height) and density of the fabricated nanopillars. For optimized process conditions, we show that by controlling the ion beam incidence angle (while rotating the sample), the shape (tapered to cylindrical) and average diameter (~75-150 nm) can be tuned and where InP nanopillar heights of ~600 nm were realized. It is shown that by modifying the shapes of the InP nanopillars, broadband anti-reflection can be obtained with average reflectance as low as ~4% in the wavelength range of 400-900 nm.
|
2022-12-02T09:52:18.119Z
|
119,925,187 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/CLEO.1999.834252",
"MAG": "1848482682",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Summary form only given. Among many other applications, femtosecond laser sources have opened a new possibility for precise and controlled modification of the irradiated material structure due to reduction of heat propagation effects at the laser energy deposition. In these experiments, tight laser focusing in the bulk or on the surface of a solid-state material is typically used to provide a needed energy concentration. In this report we present the results of a study on axicon focusing of femtosecond pulses with a moderate intensity inside transparent dielectrics to produce elongated structures in a modified material. We demonstrate interaction regimes with formation of unique solid-state material modifications in the form of channels of a micron-size diameter and the aspect ratio as large as 10/sup 4/.
|
2022-02-09T22:34:07.366Z
|
42,521,065 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/ci000072+",
"MAG": "2113021330",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A QSAR algorithm (PCANN) has been developed and applied to a set of calcium channel blockers which are of special interest because of their role in cardiac disease and also because many of them interact with P-glycoprotein, a membrane protein associated with multidrug resistance to anticancer agents. A database of 46 1,4-dihydropyridines with known Ca2+ channel binding affinities was employed for the present analysis. The QSAR algorithm can be summarized as follows: (1) a set of 90 graph theoretic and information theoretic descriptors representing various structural and topological characteristics was calculated for each of the 1,4-dihydropyridines and (2) principal component analysis (PCA) was used to compress these 90 into the eight best orthogonal composite descriptors for the database. These eight sufficed to explain 96% of the variance in the original descriptor set. (3) Two important empirical descriptors, the Leo-Hansch lipophilic constant and the Hammet electronic parameter, were added to the list of eight. (4) The 10 resulting descriptors were used as inputs to a back-propagation neural network whose output was the predicted binding affinity. (5) The predictive ability of the network was assessed by cross-validation. A comparison of the present approach with two other QSAR approaches (multiple linear regression using the same variables and a Hologram QSAR model) is made and shows that the PCANN approach can yield better predictions, once the right network configuration is identified. The present approach (PCANN) may prove useful for rapid assessment of the potential for biological activity when dealing with large chemical libraries.
|
2022-12-25T18:00:26.291Z
|
17,564,489 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1124/mol.114.096503",
"MAG": "2117966559",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc4407734?pdf=render"
}
|
Seven transmembrane receptors were originally named and characterized based on their ability to couple to heterotrimeric G proteins. The assortment of coupling partners for G protein–coupled receptors has subsequently expanded to include other effectors (most notably the βarrestins). This diversity of partners available to the receptor has prompted the pursuit of ligands that selectively activate only a subset of the available partners. A biased or functionally selective ligand may be able to distinguish between different active states of the receptor, and this would result in the preferential activation of one signaling cascade more than another. Although application of the “standard” operational model for analyzing ligand bias is useful and suitable in most cases, there are limitations that arise when the biased agonist fails to induce a significant response in one of the assays being compared. In this article, we describe a quantitative method for measuring ligand bias that is particularly useful for such cases of extreme bias. Using simulations and experimental evidence from several κ opioid receptor agonists, we illustrate a “competitive” model for quantitating the degree and direction of bias. By comparing the results obtained from the competitive model with the standard model, we demonstrate that the competitive model expands the potential for evaluating the bias of very partial agonists. We conclude the competitive model provides a useful mechanism for analyzing the bias of partial agonists that exhibit extreme bias.
|
2022-12-29T18:50:27.203Z
|
214,746,793 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2478/v10262-012-0044-0",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://content.sciendo.com/downloadpdf/journals/srj/4/1/article-p44.pdf"
}
|
Book review
|
2022-01-24T19:33:04.317Z
|
4,953,737 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/MWENT.2018.8337227",
"MAG": "2798842613",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The system of computer-aided test development is proposed in the article. The system operation is based on the model of digital device, also system allows to form test as a set of input actions and reactions of model to them. The technology for creating and debugging of tests provides a predetermined test coverage. Input actions are formed according to the interface approach. The interface approach allows to work with the model of digital device at the transaction level, but not at the signal level. This method greatly simplifies and accelerates the process of searching for test sequences. The proposed system structure supports the suggested technology and implements search of test sequences with a predetermined coverage criterion. The developed methodology allows to create a test check programs and diagnostics test program of the digital device, without any information about the destination and operation algorithm of a control object. The system checks the digital device serviceability and its operational suitability.
|
2022-03-02T16:36:57.608Z
|
102,737,997 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.12783/dtetr/apetc2017/11480",
"MAG": "2708252653",
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://doi.org/10.12783/dtetr/apetc2017/11480"
}
|
The method of solid phase extraction (SPE) combined with high performance liquid chromatography (HPLC) was established while nickel iso-nicotine MOFs was employed as adsorbent of SPE to concentrate eight kinds of PAHs in water. The chromatographic conditions, such as flow rate of mobile phase and composition of mobile phase, were investigated. Several important factors of extraction efficiency of SPE, including mass of absorbent, volume of water sample, content of methanol and pH were discussed. The detection limit, precision and recovery rate were calculated.
|
2022-05-20T07:01:42.153Z
|
149,440,432 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3406/APLIU.1989.3160",
"MAG": "2738931832",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
La prosodie est la composante la plus specifique d'une langue parlee : rythme et intonation mettent en oeuvre des processus musculaires et respiratoires particuliers a chaque langue. S'appuyant sur l'hypothese du traitement preferentiel des frequences basses par l'hemisphere cerebral droit l'appareil INTOLANG facilite et accelere l'integration de la prosodie porteuse de composantes affectives, grammaticales et semantiques de la parole en langue etrangere.
|
2022-09-02T13:55:49.753Z
|
109,983,017 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1287/INTE.23.1.59",
"MAG": "2147682776",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Mexican and US firms and universities are working together to turn a Mexican-USA truck company, Vilpac, into a world class manufacturing firm. A systems integrated enterprise and manufacturing architecture is enabling the firm to successfully manufacture and sell trucks meeting international standards. The company has increased production by 260 percent, reduced fixed total costs by 26 percent, and increased net profits by 70 percent within 18 months. An IDEF functional model helped Vilpac to identify simplification opportunities. The firm launched three long-term, five medium-term, and 19 short-term projects of high strategic impact. A SIMNET II computer simulation model of the entire fabrication process monitors the load of over 95 machines and follows the work in process of over 1,900 parts. It works under push or pull control environments and predicts daily production accurately. It permits the testing of manufacturing configurations and is being used to design a new plant based on group technology an...
|
2022-09-06T05:20:50.250Z
|
46,464,224 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1176/PS.48.4.524",
"MAG": "2461121341",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
As part of an evaluation of the Utah Prepaid Mental Health Plan, the Process of Care Review Form was developed to assess the quality of the process of psychiatric care provided by Utah's community mental health centers (CMHCs) to clients with schizophrenia. This article briefly reviews issues in the measurement of quality of care and describes the development and implementation of the form. The 67-item form was designed for use by a trained abstracter to gather data from CMHC medical records in six areas: general management of the patient, medication management, medical management, social support, psychiatric hospitalization, and psychiatric assessment. A 59-item version of the form that omits the section on psychiatric assessment has been used in three waves of data collection to document data spanning five years (1990-1994) in the evaluation of the process of psychiatric care in the Utah plan. It is currently being used longitudinally to examine differences between Utah CMHCs receiving capitated payments and those paid on a fee-for-service basis by Medicaid.
|
2022-09-07T05:46:03.351Z
|
25,351,854 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1345/aph.17455",
"MAG": "2166767686",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
OBJECTIVE: To review the literature and provide recommendations for the development and dissemination of written medication information to patients and their care providers. DATA SOURCES: A MEDLINE search (1966–1997) of the English-language literature was performed to identify articles pertaining to the development or use of written medication information. A search of the Internet was conducted by using Yahoo as the guide and “medication information” as the search term. Additional resources were obtained through texts, bibliographies, and catalogs from medical publishers. DATA EXTRACTION: Reports documenting the creation and use of written medication information systems were reviewed, as well as studies of readability and reading skills assessment. Examples of materials available for purchase by laypeople and healthcare providers were also examined. DATA SYNTHESIS: Current statistics support the widespread availability of written medication information for patients and care providers. The goal set forth by the Food and Drug Administration of having 75% of patients receive written information by the year 2000 appears achievable. However, there are still many issues to address. Content is not standardized, and materials are frequently written at reading levels higher than that of the average patient. The development and use of resources requiring only minimal reading skills and an increase in the availability of materials written in Spanish are needed. CONCLUSIONS: Written medication information provides a useful addition to counseling by healthcare professionals. A wide variety of prepared materials is available, as well as resources for those interested in developing tools for a specific patient, population, or setting. Healthcare professionals should be aware of the limitations of some resources. Content and readability must be appropriate for the intended audience for these tools to serve a useful role in patient education.
|
2022-09-13T17:36:09.862Z
|
238,924,345 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/TAP.2021.3102023",
"MAG": "3190611606",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this article, a metal resonator design of enabling wireless charging of a metal-encased device was demonstrated using a two-coil magnetic resonant system operating at 6.78 MHz. Despite high metal population on metal housing, the transmitting magnetic field was efficiently linked to the receiving resonator through segmenting the metal housing with a small gap. In addition to the initially transmitting magnetic fields passing through the gap, extra magnetic fields were generated by the eddy currents induced on the segmented metal housing. These two magnetic fields were added up in phase and used to couple to the power-receiving coil. The principle of operation was demonstrated with electromagnetic simulation and measurement. Furthermore, a prototype of metal housing, including the power-receiving coil and ferrite, was fabricated and integrated with a commercial smartphone. The measurement results showed 86% of resonator coupling efficiency (RCE) with an aluminum metal casing of the device when tested with a regular Class 3 AirFuel Alliance (AFA)-compatible transmitter. Actual measured power delivered to a smartphone battery was 8.7 W at maximum coupling position with 89% of the RCE.
|
2022-09-30T04:39:28.167Z
|
145,465,864 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3917/RI.161.0081",
"MAG": "2100114554",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Cet article examine l’action humanitaire de l’association lausannoise Terre des hommes a ses debuts, durant les guerres d’Algerie et du Vietnam, de 1960 a 1969. Il porte sur son activite phare, l’adoption de fait et de droit d’enfants etrangers en Suisse. Il s’agit d’apprehender, d’une part, les relations de Terre des hommes avec le Comite international de la Croix-Rouge et l’Etat federal suisse, et d’autre part, le processus de modernisation du droit de l’adoption suisse.
|
2022-11-11T17:36:59.463Z
|
41,539,113 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2217/17455057.4.2.127",
"MAG": "2011028491",
"PubMedCentral": null
},
"license": "CCBYNC",
"status": "GOLD",
"url": "https://doi.org/10.2217/17455057.4.2.127"
}
|
Evaluation of: Rocca WA, Bower JH, Maraganore DM et al.: Increased risk of cognitive impairment or dementia in women who underwent oophorectomy before menopause. Neurology 69(11), 1074–1083 (2007). This study examines the incidence of dementia in a population of women who underwent unilateral or bilateral oophorectomy before menopause. Patients were drawn from the Mayo Clinic database and included women who had surgical removal of either one or both ovaries during a preceding 40-year period (1950–1987), as well as a reference group of women who did not undergo oophorectomy. Women who agreed to participate in the study were interviewed by phone and received a modified Telephone Interview for Cognition or a brief dementia questionnaire answered by a proxy if the subject was deceased or incapacitated. Women who had unilateral oophorectomy had a greater incidence of dementia as compared with surgical controls. In women with bilateral oophorectomies, the risk for dementia was increased in women who were younger at the time of surgery as well as in women who discontinued estrogen therapy before 50 years of age.
|
2022-12-11T08:04:58.826Z
|
16,827,938 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1155/2013/295153",
"MAG": "1983155191",
"PubMedCentral": "3816020"
},
"license": "CCBY",
"status": "GOLD",
"url": "http://downloads.hindawi.com/journals/bmri/2013/295153.pdf"
}
|
Background. Studies have suggested that albumin has a value in cirrhotic patients undergoing paracentesis but its value in infection and sepsis is less clear. We planned to perform a meta-analysis of the risk of adverse outcomes in cirrhotic patients with and without albumin use. Methods. We searched MEDLINE and EMBASE in January 2013 for randomized studies of cirrhotic patients that reported the risk of adverse events and mortality with albumin and no albumin exposure. We performed random effects meta-analysis and assessed heterogeneity using the I2 statistic. Results. Our review included 16 studies covering 1,518 patients. The use of albumin in paracentesis was associated with significantly reduced risk of paracentesis-induced circulatory dysfunction (OR 0.26 95%, CI 0.08–0.93) and there was a nonsignificant difference in death, encephalopathy, hyponatraemia, readmission, and renal impairment. Compared to the other volume expanders, albumin use showed no difference in clinical outcomes. In cirrhotic patients with any infection, there was a significant reduction in mortality (OR 0.46 95%, CI 0.25–0.86) and renal impairment (OR 0.34 95%, CI 0.15–0.75) when albumin was used. Conclusion. The use of albumin in cirrhotic patients is valuable in patients with any infection and it reduces the risk of circulatory dysfunction among patients undergoing paracentesis.
|
2022-12-18T18:00:30.863Z
|
249,439,207 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1200/jco.2022.40.16_suppl.e23014",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
e23014 Background: As the oncology patient population grows, continued recruitment of talented individuals is essential. Meaningful and highly educational clinical exposures play a crucial role in a resident’s decision to pursue fellowship in oncology. Currently, the majority of oncology exposure occurs in the inpatient setting, where trainees are confronted with many competing clinical demands, leaving minimal time for teaching. Prior work has demonstrated that dedicated time for teaching supplemented with high-yield educational material improves trainee satisfaction and interest in a particular field. We hypothesize that implementing an asynchronous inpatient video oncology curriculum will improve resident clinical competency and satisfaction. Methods: This is an ongoing, single institution educational intervention using the Kern method for curriculum development in the Johns Hopkins Osler Internal Medicine Residency (IRB00307077). A targeted needs assessment has been developed to identify gaps in medical knowledge, assess preparedness in managing common solid tumor inpatient diagnoses, and explore satisfaction with prior educational experiences on this service. Based on these results, ten educational videos will be created by content experts and aligned with the learning objectives of the Osler residency program and ABIM blueprint. Trainees will have dedicated time to watch the videos during their solid tumor rotation. We plan to evaluate effectiveness of our curriculum by measuring completion rates and pre- and post-video multiple choice responses. We will also assess knowledge retention and resident satisfaction at three and six months post-rotation with online questionnaires. Results: Annual Osler program ACGME survey data review revealed a high level of resident dissatisfaction with the oncology clinical experience compared with other rotations. While 83.3% of residents rated their general internal medicine experience as “excellent,” only 52.4% rated their oncology experience as “excellent.” Needs assessment data collection has been delayed by the COVID-19 pandemic but is ongoing. Following topic selection, videos will be created in April 2022 with plans for video curriculum implementation in July 2022. Conclusions: In order to attract and retain trainees in the field of oncology, it is imperative that educational curricula adapts to meet learners’ needs. Efficient, evidence-based instructional strategies designed to promote clinical competency for internal medicine residents on an inpatient solid tumor service may foster engagement and rotation satisfaction. We are currently evaluating how an asynchronous video inpatient oncology curriculum may significantly improve the inpatient internal medicine trainee experience. If successful, this curriculum can be adapted for other trainees and practitioners new to the field of oncology.
|
2022-12-18T10:10:40.280Z
|
134,533,318 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1144/SP472.15",
"MAG": "2816045719",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract The Paleozoic Parnaíba Basin has proven to be one of the most successful onshore gas basins in Brazil. Since 2010, seven gas fields have been declared as commercial. Conventional gas accumulations occur in the Devonian Cabeças Formation sandstone, Upper Devonian/Lower Carboniferous heterolitic sandstones of the Longá Formation, Carboniferous Poti Formation arkosic-sandstones and in the Upper Carboniferous Piauí Formation sandstones. The stacked geometry of an extensive Mesozoic igneous complex is responsible for the creation of several four-way structures and compartmentalization of both source rock and reservoirs. The dolerite sills intrude the organic-rich intervals of the Devonian Pimenteiras shale, triggering maturity and hydrocarbon generation, thus creating an atypical igneous–sedimentary petroleum system. Major seismic concerns are the complexity of imaging subigneous plays, the large areal extent of the basin, strong velocity heterogeneity and the difficulty of imaging high-angle or vertical sealing structures, critical to prospect success. The recognition and understanding of this atypical igneous–sedimentary petroleum system could be used to unlock the potential of analogue basins worldwide and also to expand the exploration successful cases in the Parnaíba Basin itself.
|
2022-12-17T20:55:40.241Z
|
248,245,951 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1097/RTI.0000000000000630",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Purpose: The purpose of our study was to determine if the ratio of right–to-left ventricular diameter (RV/LV ratio) on computed tomography (CT) pulmonary angiograms (CTPA) is predictive of 90-day mortality in patients without pulmonary embolism (PE). Materials and Methods: This Institutional Review Board-approved single-institution retrospective study was performed on patients who underwent CTPA in the emergency or inpatient setting over a 1-year period. Right and left ventricular diameters were measured and RV/LV ratios calculated for patients without acute PE. Ratios greater than or equal to 0.9 were considered abnormal. Univariate analysis was performed for the outcome of death within 90 days of CT. Multivariable analysis was also performed to control for age, sex, and lung disease. Results: Of the 423 patients included in the study, 55 patients died within 90 days of CT. An RV/LV ratio ≥0.9 was predictive of 90-day mortality: of the 226 patients with RV/LV ≥0.9, 42 (18.6%) died within 90 days, compared with 13 of 197 patients without abnormal ratio (6.6%), with odds ratio (OR) of 3.23 (95% confidence interval [CI]: 1.68-6.22; P<0.01). In multivariate analysis, RV/LV ratio had an OR of 5.19 per unit increase (95%CI: 1.06-25.42; P=0.04); age had an OR of 1.04 per year increase (95% CI: 1.01-1.06; P<0.01). Conclusion: Increased RV/LV ratio is a negative prognostic factor even in patients without acute PE and may be a useful CT biomarker to include in radiology reports for all patients undergoing CTPA.
|
2022-05-04T19:25:19.410Z
|
40,835,258 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.2042-7158.1985.tb05037.x",
"MAG": "2023031211",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
[3 H]Adrenaline was incorporated in an isolated perfused preparation of the rabbit adrenal gland and the effects of indomethacin, PGE2 and PGI2 on its release were investigated. Efflux of [3 H]adrenaline was elicited by electrical stimulation of the splanchnic nerve (60 s at 5 Hz). Indomethacin (3 and 30 μM) had no effect on stimulation‐induced efflux. PGE2 (30, 90 and 300 nM) reduced the efflux; with 90 nM PGE2 the inhibition amounted to approximately 30%. PGI2, in concentrations from 90 to 600 nM, was without effect. These findings indicate that release of [3 H]adrenaline from the rabbit adrenal gland is not subject to modulation by endogenous adrenal prostaglandins; however, PGE2 may play a role in some pathological situations.
|
2022-06-20T13:11:12.274Z
|
216,984,852 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5007/1518-2924.2008V13N26P119",
"MAG": "2997165811",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Neste artigo analisa-se, do ponto de vista da arquitetura da informacao, baseada no usuario, o website da Biblioteca Virtual em Saude – BVS, site de responsabilidade da BIREME. Para tanto se usa como referencial a Ciencia da Informacao, que colabora com seus estudos de usuarios e suas necessidades de informacao, para sugerir mudancas e consequentemente, a melhoria da qualidade do produto final, do projeto de arquitetura da informacao do website da BVS.
|
2022-09-02T06:06:01.651Z
|
247,654,175 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1049/icp.2021.2529",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
When the controlled current source converter is applied to HVDC transmission system composed by the pulse width modulated current source converter(PWM-CSC) and Line-Commutated Converter(LCC), the dc voltage at both ends of the converter does not match due to the bypass of the PWM-CSC. Based on the operating principle of PWM-CSC, this paper analyses the dc voltage characteristics of TPWM applied to the current source converter, and realizes the unit power factor operation of the system combined with the indirect current control and TPWM.
|
2022-09-29T21:54:46.693Z
|
231,604,666 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1158/1078-0432.CCR-20-3716",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Purpose: Investigate the safety and efficacy of LY3415244, a TIM-3/PD-L1 bispecific antibody that blocks TIM-3 and PD-L1 in patients with advanced solid tumors. Patients and Methods: A phase I, multicenter, open-label study was conducted in patients with advanced solid tumors. Patients were dosed every 2 weeks intravenously with flat doses of LY3415244 escalating from 3 to 70 mg. The primary endpoints were safety, tolerability, and identification of the recommended phase II dose. Results: Between November 2018 and October 2019, 12 patients were enrolled into four cohorts and received at least one dose of LY3415244. Two patients (16.7%) developed clinically significant anaphylactic infusion-related reactions and all patients developed treatment-emergent antidrug antibodies (TE-ADA). ADA titers were sometimes very high and negatively impacted soluble TIM-3 target engagement in most patients. ADA epitope specificity was against both TIM-3 and PD-L1 arms of the bispecific antibody; most TE-ADAs initially targeted the TIM-3 arm after the first dose. Preexisting ADAs against LY3415244 were also detected in normal (unexposed) human serum samples. One patient with PD-1 refractory non–small cell lung cancer had a near partial response (−29.6%). Conclusions: This TIM-3 and PD-L1 bispecific format was associated with unexpected immunogenicity targeting both arms of the bispecific antibody, resulting in early study termination. Epitope specificity analysis revealed an initial response toward the TIM-3 arm and presence of preexisting ADAs to the bispecific molecule in the general population. This experience emphasizes the importance of thorough analyses for preexisting ADAs as part of immunogenicity risk assessment of novel antibodies. See related commentary by de Spéville and Moreno, p. 2669
|
2022-12-18T04:18:04.024Z
|
162,403,018 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2307/3557033",
"MAG": "2069264187",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Recent excavations and reanalysis of existing data on communal pit structures provide intriguing insights into ritual and cultural developments over a period of about 350 years, from A.D. 800 to 1140, in the Mimbres Valley of southwestern New Mexico. In the middle of this period, people shifted dwellings from pithouses to pueblos, a shift previously viewed as the pivotal transformation of Mimbres society. In this paper we show that significant changes in Mimbres society began in the A.D. 800s. Trends in the construction methods of communal pit structures, the placement of dedicatory items within them, their ritual retirements, and their long-lived significance within Mimbres villages, reflect other changes that occurred in Mimbres society. We contend that in the A.D. 800s, rapid change based on strong connections with the Hohokam of southern Arizona and agricultural intensification began a trajectory that culminated in the Classic Mimbres pueblos of the A.D. 1000s and early 1100s.
|
2022-12-19T20:20:10.754Z
|
9,270,253 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/bcpt.12294",
"MAG": "2090630995",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bcpt.12294"
}
|
PPC‐5650 is a new pharmacological agent that can modulate acid‐sensing ion channel activity, leading to a reduction in the pain signal under up‐regulated conditions. The non‐clinical programme for PPC‐5650 supported a role for this novel agent in the treatment of pain in patients with irritable bowel syndrome (IBS). In patients with IBS, the aims of the study were: (1) to assess the efficacy of a single bolus of PPC‐5650 locally applied in the rectum using multi‐modal stimulations of the recto sigmoid and (2) to assess the safety profile of PPC‐5650. The study was a randomized, double‐blind, placebo‐controlled, cross‐over trial in patients with IBS, excluding females of child‐bearing potential. The study consisted of a training visit, study visit 1 and 2 and a follow‐up visit. Rectosigmoid electrical, thermal and mechanical stimulations were performed, pain perception was rated on a pain intensity scale and referred pain areas were assessed. All adverse events were registered.
|
2022-12-22T19:06:08.078Z
|
211,950,431 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.15332/tg.pre.2020.00076",
"MAG": "2983287723",
"PubMedCentral": null
},
"license": "CCBYNCND",
"status": "HYBRID",
"url": "http://repository.usta.edu.co/bitstream/11634/15137/5/2018jennygonzalez.pdf"
}
|
En este informe se podra evidenciar el aprendizaje de las empresas en tiempos de crisis y su crecimiento organizacional, tomando como ejemplo la empresa Super Bol, compania que fue visitada durante el periplo internacional realizado en la ciudad de Buenos Aires, Argentina, el 12 de noviembre de 2018.
Durante esta investigacion se tomaron diferentes conceptos de crecimiento organizacional, mediante teorias y posturas de varios autores, en los cuales se explican temas como: concepto de crecimiento, crecimiento empresarial de pequenas, medianas y grandes empresas, creatividad, innovacion y publicidad.
Obtenida esta informacion, se procedio a organizar y aclarar cada uno de los conceptos, con el fin de tener informacion relevante al momento de realizar la visita y asi poder generar preguntas pertinentes que ayuden con el tema de investigacion.
En la empresa, se realizo una presentacion a cargo del senor Federico Fernandez Gerente de Desarrollo y Control de Gestion, donde hablo de la trayectoria de la compania y como ha podido mantenerse a lo largo de los anos enfrentando cada una de las crisis economicas del pais, cambios tecnologicos y tendencias a nivel mundial. Se procedio luego a realizar un recorrido por la planta, donde fue explicado cada uno de los procesos de produccion y logisticos de la compania, finalizando con una serie de preguntas para poder aclarar algunos temas.
|
2022-02-08T03:04:16.678Z
|
159,059,683 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.33375/VSLT.V7I2.1455",
"MAG": "2920007996",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Batik Rifa’iyah is a batik created and developed by followers of Shaikh Ahmad Rifa’i, also known as the Rifa’iyah. The tradition stemmed from Shaikh Ahmad Rifa’i's prohibition of drawing living beings. Today, the Batik making tradition is in decline, and would go extinct without proper preservation efforts. One way to preserve the tradition is by passing the Rifa’iyah batik making tradition to the next generation of the community. This study is limited to the next generation of Rifa’iyah community in Kalipucan Wetan whose age between 15-30 years old. This study focuses on one of batik making technique called the klowong. The study’s methodology is adopted from ethnographic approaches. The approach analyzes socio-cultural aspects, of which are experimented and applied by using the klowong technique to pass down the batik making tradition to Rifa’iyah in Kalipucang Wetan. Qualitative methods used are literature studies, field study by observation, in-depth interviews, voice recordings, and photography. Currently, the klowong technique is passed down by imitation. Preservation of the klowong technique requires innovation to help apprentices learn the technique. It is found different models of passing down the klowong technique are required to suit a batik maker’s skills.
|
2022-02-08T23:26:05.763Z
|
124,506,628 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2534/JJASNAOE1952.1955.97_57",
"MAG": "2321963768",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In the case of plastic buckling of a structure, the critical state largely depends upon the initial deflection; this makes the load in the critical state decrease. In the present paper, as regards column and plate with initial deflections, their behavior under compressive load is theoretically investigated, by using the so-called Shanley model and the extended Shanley model for plate.Even if the critical stress for column or plate without any initial deflection is within the elastic range, the existence of the initial deflection makes the critical stress decrease. In the case of the plate with small initial deflection, it is confirmed that“the greatest lower bound of the Karman state” proposed by the present author in his previous paper [5] is regarded as the critical state for practical purpose ; when it is compressed one-directionally, the stress in this state is almost equal to the so-called reduced modulus stress in classical sense. Whatever the initial deflection may be, the critical stress of compressed column or plate compressed one-directionally is not less than the stress, peEt∞E, where pe is the elastic critical stress, Et∞ is the tangent modulus corresponding to large tensile strain and E is Young's modulus.
|
2022-02-09T18:27:42.559Z
|
220,927,469 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/030857597809200216",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Statistics Now we are going to cover how to perform a variety of basic statistical tests in R. • Correlation • T-tests • Linear Regression • Logistic Regression • Proportion tests • Chi-squared • Fisher’s Exact Test Note: We will be glossing over the statistical theory and “formulas” for these tests. There are plenty of resources online for learning more about these tests, as well as dedicated Biostatistics series at the School of Public Health
|
2022-07-01T05:04:07.482Z
|
94,440,622 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/JACE.12447",
"MAG": "1757719594",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Zn2GeO4 ceramic materials were synthesized by the solid-state method. Zn2GeO4 powders were investigated with X-ray powder diffraction (XRD) and high-resolution transmission electron microscopy (HRTEM). Oxygen defects in the Zn2GeO4 ceramics were investigated by photoluminescence, Raman, and EDS spectra. Conductivity of Zn2GeO4 was 0.18 S/cm at low temperature of 773 K, and its activation energy was 0.49 eV. The results showed that Zn2GeO4 was a promising low-temperature electrolyte with high conductivity.
|
2022-09-06T22:00:44.406Z
|
119,649,254 |
{
"externalids": {
"ACL": null,
"ArXiv": "1101.2935",
"DOI": "10.1088/0253-6102/57/1/05",
"MAG": "2952338939",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "http://arxiv.org/pdf/1101.2935"
}
|
With the help of the Drinfeld twist or factorizing F-matrix for the eight-vertex solid-on-solid (SOS) model, we find that in the F-basis provided by the twist the two sets of pseudo-particle creation operators simultaneously take completely symmetric and polarization free form. This allows us to obtain the explicit and completely symmetric expressions of the two sets of Bethe states of the model.
|
2022-09-23T08:30:45.817Z
|
85,356,944 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1139/O74-034",
"MAG": "2071301169",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Three crystalline modifications of the bacterial serine peptidase Streptomyces griseus Protease B have been grown. A 4.5 A resolution electron density map of one form has been computed from the multiple isomorphous replacement (MIR) phases deduced from two heavy metal derivatives plus the anomalous dispersion effects of one of the derivatives. The crystalline modification used was grown from 0.7–1.0 M KH2PO4 at pH 4.2. These crystals have space group P21212 and unit cell dimensions of a = 44.15 (5) A, b = 108.72 (10) A, and c = 37.28 (5) A. The crystal asymmetric unit contains a protein mass of approximately 19 000 daltons. The electron density map, mean figure of merit 0.80, clearly shows the molecular boundary; relatively long stretches of extended chain are discernable. The active site has been identified from a difference electron density map computed using the MIR protein phases and the amplitude differences between a crystal of the enzyme inhibited at the active serine in solution by p-iodobenzenesu...
|
2022-12-09T04:48:55.120Z
|
16,422,800 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1155/2008/289184",
"MAG": "3005190167",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://doi.org/10.1155/2008/289184"
}
|
A general formulation based on multirate filterbank theory for analog-to-digital converters using parallel sigmadelta modulators in conjunction with modulation sequences is presented. The time-interleaved modulators (TIMs), Hadamard modulators (HMs), and frequency-band decomposition modulators (FBDMs) can be viewed as special cases of the proposed description. The usefulness of the formulation stems from its ability to analyze a system's sensitivity to aliasing due to channel mismatch and modulation sequence level errors. Both Nyquist-rate and oversampled systems are considered, and it is shown how the matching requirements between channels can be reduced for oversampled systems. The new formulation is useful also for the derivation of new modulation schemes, and an example is given of how it can be used in this context.
|
2022-12-10T21:28:18.721Z
|
232,435,550 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.35784/acs-2019-26",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://ph.pollub.pl/index.php/acs/article/download/3208/2845"
}
|
The presented research deals with the development of the numerical model for resins used for stereolithography (SLA) rapid prototyping. SLA is an additive method of production of models, prototypes, elements or parts of constructions with the use of 3D printing that covers photochemical processes by which light causes chemical monomers to link together to form polymers. Such method is very useful in design visualization, but also can be applied in numerical modelling for the purpose of validation and verification. In this application the resin strength parameters must be described and on the base of them the numerical material model is developed and validated. Such a study for SLA resins was presented in the paper.
|
2022-12-16T14:37:35.832Z
|
54,472,103 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/bioinformatics/bty1006",
"MAG": "2905446269",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://research-repository.griffith.edu.au/bitstream/10072/383664/1/Hanson178819.pdf"
}
|
Motivation
Sequence-based prediction of one dimensional structural properties of proteins has been a long-standing subproblem of protein structure prediction. Recently, prediction accuracy has been significantly improved due to the rapid expansion of protein sequence and structure libraries and advances in deep learning techniques, such as residual convolutional networks (ResNets) and Long-Short-Term Memory Cells in Bidirectional Recurrent Neural Networks (LSTM-BRNNs). Here we leverage an ensemble of LSTM-BRNN and ResNet models, together with predicted residue-residue contact maps, to continue the push towards the attainable limit of prediction for 3- and 8-state secondary structure, backbone angles (θ, τ, ϕ, and ψ), half-sphere exposure, contact numbers, and solvent accessible surface area (ASA).
Results
The new method, named SPOT-1D, achieves similar, high performance on a large validation set and test set (≈1000 proteins in each set), suggesting robust performance for unseen data. For the large test set, it achieves 87% and 77% in 3 and 8-state secondary structure prediction and 0.82 and 0.86 in correlation coefficients between predicted and measured ASA and contact numbers, respectively. Comparison to current state-of-the-art techniques reveals substantial improvement in secondary structure and backbone angle prediction. In particular, 44% of 40-residue fragment structures constructed from predicted backbone Cα-based θ and τ angles are less than 6Å root-mean-squared-distance from their native conformations, nearly 20% better than the next best. The method is expected to be useful for advancing protein structure and function prediction.
Availability
SPOT-1D and its data is available at: http://sparks-lab.org/.
Supplementary Information
Supplementary data is available at Bioinformatics online.
|
2022-12-29T15:56:27.560Z
|
246,135,687 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.29333/jcei/11583",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.jceionline.org/download/co-morbidity-and-covid-19-a-study-of-case-severity-and-early-outcome-11583.pdf"
}
|
Background: The corona virus disease 2019 (COVID-19) has spread around the world and mutating rapidly. It is absolutely essential to evaluate the potential risk factor influencing disease progression and better understanding of high risk co-morbidities among COVID-19 patients. Objectives: To evaluate the association of serious events in COVID-19 patients according to the number and type of co-morbidities also the association of co-morbidities with the adverse events and the risk of early outcomes with any co-morbidity. Methods: This was a prospective observational study among 1,583 laboratory-confirmed COVID-19 cases admitted during the study period from Apr 2020 to March 2021. Odds ratio (OR) and risk ratio (RR) with respective confidence intervals have been calculated to evaluate the presence and strength of association of case severity with the presence and number of co morbidities. Results: There was 302 study subjects with one or more than one co-morbidities having the mean (SD) age of 54(15) year and 206(68.2%) male cases compared to female. The leading comorbidities were diabetes (146, 9.2%), hypertension (142, 9%) with respiratory disease (50, 3.2%), CAD (16, 1%). Any co-morbid patient has 6 times odds of getting admitted in ICU in comparison to non-co-morbid patient while the risk ratio signifies that five times higher chance of getting admitted in ICU than any non-co-morbid patient. The chances of death in them are always higher than non-co-morbid specially diabetes and hypertensive with CAD. Conclusions: Among patients with COVID-19 disease any co-morbidity resulted to poorer clinical outcomes and more the number of co-morbidities, poorer the clinical outcomes. [ FROM AUTHOR];Copyright of Journal of Clinical & Experimental Investigations is the property of Modestum Publications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)
|
2022-05-20T07:16:18.505Z
|
93,534,525 |
{
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"ArXiv": null,
"DOI": "10.1080/00218469908009559",
"MAG": "1986923558",
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},
"license": null,
"status": null,
"url": null
}
|
Abstract The effects of the hydrolysis and condensation processes on the molecular structure of γ-glycidoxypropyltrimethoxysilane (γ-GPS) in aqueous solutions were investigated using Fourier-transform nuclear magnetic resonance (FT-NMR) spectroscopy and FT-Raman spectroscopy. Hydrolysis was characterized by monitoring the production of methanol and the decrease in concentration of SiOCH3 groups in 1% solutions of deuterium oxide using proton NMR. The production of methanol and loss of methoxy groups in 25% solutions of γ-GPS in water was characterized using Raman spectroscopy. Hydrolysis was found to be a very rapid process, whose rate could be increased or decreased by altering the pH of the solution. NMR spectroscopy showed that hydrolysis was complete in a 1% γ-GPS solution in deuterium oxide after 34 minutes. Raman spectroscopy also showed hydrolysis to be rapid and complete in a 25% solution of γ-GPS in water after 1 hour. Condensation, on the other hand, took a relatively long time to occur. In the ...
|
2022-07-31T07:45:09.862Z
|
169,729,106 |
{
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"ArXiv": null,
"DOI": "10.1108/S0733-558X20180000056007",
"MAG": "2883437154",
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},
"license": null,
"status": null,
"url": null
}
|
Previous work has shown that corporate social responsibility (CSR) initiatives can preserve shareholder value after an organization experiences a negative event. I expand on this theory by examining one boundary condition that could lead to the opposite relationship: when the organization has a CSR initiative intended to prevent the type of event that occurs. The author argues that activist pressure will enhance the negative relationship between event-specific CSR and shareholder value. Using an event-study, the author examines the apparel industry after the collapse of Rana Plaza which killed over a thousand apparel supply chain employees.
|
2022-08-28T12:49:06.619Z
|
86,419,379 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1051/ANIMRES:199505215",
"MAG": "2094310224",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
(lactating vs dry) and sward height on the intake of grass and its behavioural components. A group of 12 Limousine x Romanov 3-6 year old ewes, six of them dry and the other six suckling twins for 6 weeks, were strip-grazed on short (4-6 days old) leafy cocksfoot regrowths. Another similar group at the same time grazed longer (3 weeks old) and mainly leafy regrowths. The short sward was grazed from 10 down to 6 cm high measured with a sward stick, and the tall one from 20-25 down to 12-15 cm. Grass intake (IG) was estimated individually by the alkanes’ technique (Mayes et al, 1986, J Agric Sci, 107, 161-170). The external marker (C32) was given for 12 successive days ; faeces and hand plucked grass samples were obtained each morning during the last 9 days. Daily grazing time (GT ; head down) was recorded on one day every 10 min from before the ewes stood up at dawn to after all ewes stopped grazing at dusk (15 5
|
2022-09-30T01:02:01.423Z
|
198,650,414 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1108/SEF-11-2017-0318",
"MAG": "2954665033",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Purpose
This paper aims to model the asset portfolio rebalancing decisions of Australian households experiencing a severe life event shock.
Design/methodology/approach
The paper uses household longitudinal data from the Household, Income, and Labour Dynamics in Australia (HILDA) survey since 2001. The major life events are serious illness or injury, death of a spouse, job dismissal or redundancy and separation from a spouse. The asset classes are bank accounts, cash investments, equities, superannuation (private pensions), life insurance, trust funds, owner-occupied housing, investor housing, business assets, vehicles and collectibles. The authors use both static and dynamic Tobit models to assess the impact and duration of impact of the shocks.
Findings
Serious illness and injury, loss of employment, separation and spousal death cause households to rebalance portfolios in ways that can have detrimental effects on long-term wealth accumulation through poor market timing and the incurring of transaction costs.
Research limitations/implications
The survey results are only available since 2001, and the wealth module from which the asset data are drawn is self-reported and not available every year.
Practical implications
Relevant to policymakers working on the ongoing retirement of the “baby boomer” generation and for financial planners guiding household investment decisions.
Originality/value
Most research on shocks to household wealth concern a narrower range of assets and only limited shocks. Also, this is one of the few studies to use a random effects model to allow for unspecified heterogeneity among households.
|
2022-11-04T00:45:06.169Z
|
20,615,739 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1172/JCI115127",
"MAG": "2030028094",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
To discern the mechanism(s) that underlie abnormal cholesteryl ester transfer (CET) in patients with hypercholesterolemia, we have studied this dysfunctional step in reverse cholesterol transport in 13 subjects with genetically heterogeneous forms of hypercholesterolemia (HC). In all HC patients, the mass of CE transferred in whole plasma from HDL to VLDL and LDL increased rapidly initially and was significantly greater than in controls at 1, 2, and 4 h (P less than 0.005). To further characterize this disturbance, we performed a series of recombination experiments. Combining HC d less than 1.063 containing acceptor VLDL + LDL with the d greater than 1.063 fraction from controls containing donor HDL + CE-transfer protein (CETP) and not the converse combination showed the same characteristics of accelerated CET noted with intact HC plasma, indicating that abnormal transfer was associated with the HC acceptor lipoproteins. When HC VLDL and its subfractions and LDL were isolated separately and then combined with control d greater than 1.063 fractions, accelerated CET was only associated with VLDL1. Consistent with an acceleration of the neutral lipid transfer reaction occurring between HDL and VLDL1 in HC in vivo, we found that the triglyceride/CE ratio was decreased in HC VLDL1 (P less than 0.001), and increased in HDL (P less than 0.25). CETP mass was significantly increased in HC plasma (HC 2.3 +/- 4 micrograms/ml vs. control 1.3 +/- 0.3 micrograms/ml; mean +/- SD; P less than 0.025). This series of observations demonstrate that CET is accelerated in the plasma of HC patients, and this disturbance results from dysfunction of the VLDL1 subfraction rather than an elevation of CETP levels. Since an abnormality of this type in vivo can lead to the accumulation of potentially atherogenic CE-enriched apoB-containing lipoproteins in plasma, it may be an additional previously unrecognized factor that increases cardiovascular risk in HC patients.
|
2022-12-02T13:19:57.432Z
|
46,053,328 |
{
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"ArXiv": null,
"DOI": "10.1210/ENDO-127-4-1640",
"MAG": "2031472421",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Glucocorticoid effects on insulin biosynthesis and secretion have been controversial. To define whether glucocorticoids affect insulin biosynthesis in vitro, the actions of dexamethasone on insulin gene expression were examined using the HIT cell line, a transformed clonal line of hamster beta-cells. Dexamethasone induced a dose-dependent decrease in steady-state insulin messenger RNA (mRNA) levels, which was prevented by adding an excess of RU 486, a competitive inhibitor for the binding to the glucocorticoid receptor. Inhibition was not observed before 6 h of dexamethasone treatment and was maximal at 24 h. To further assess the molecular mechanisms of the dexamethasone-induced decreases in insulin mRNA levels, we investigated whether transcription of the insulin gene was affected. Run-on assays revealed that transcription rates were not changed by glucocorticoids. Inhibition of RNA and protein synthesis by actinomycin D and cycloheximide, respectively, completely abolished the dexamethasone effects, whereas actinomycin D added 9 h after dexamethasone had no effect on insulin mRNA levels. The present results demonstrate that glucocorticoids can acutely inhibit insulin biosynthesis by destabilizing insulin mRNA; this effect requires the transcriptional activation of a gene encoding a protein responsible for the accelerated disappearance of insulin mRNA.
|
2022-12-14T09:18:16.656Z
|
22,288,596 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1109/TMAG.2004.829249",
"MAG": "2143594563",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
One way to measure nonlinear harmonic amplitudes associated with a steel plate is to measure the secondary electromotive forces (EMFs) in air coils above and below the plate when the field is generated by ac currents in primary coils also above and below the plate. The flux density inside the plate is not being measured in this case, but rather the flux density of the stray field outside the material. The harmonic behavior of this stray field is different from the harmonic behavior of the flux density inside the material itself. Indeed, as a demonstration of this different behavior, we present finite-element modeling (FEM) for the given configuration using ANSYS EMAG 2D in the transient mode (with eddy currents turned on in the plate). It is found, after Fourier transforming the computed EMF in the secondary coils, that the third harmonic actually increases with increasing dislocation density and decreasing grain size (or, equivalently, with increasing tensile strength). This behavior is opposite in trend to what is found for the flux density inside the material from prior modeling or from experiment. An explanation for this is provided in the paper. The increase in the third harmonic is not only predicted by the FEM, but also by measurements with air coils, as cited in this paper.
|
2022-12-17T21:42:27.690Z
|
7,203,443 |
{
"externalids": {
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"DOI": "10.1128/aem.58.9.2832-2839.1992",
"MAG": "1803205267",
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},
"license": null,
"status": "GREEN",
"url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC183015"
}
|
Forty-nine isolates of Bradyrhizobium japonicum indigenous to a field where soybeans were grown for 45 years without inoculation were characterized by using four DNA hybridization probes from B. japonicum. nifDK-specific hybridization clearly divided the isolates into two divergent groups. Diversity in repeated-sequence (RS)-specific hybridization was observed; 44 isolates derived from 41 nodules were divided into 33 different RS fingerprint groups. Cluster analysis showed that the RS fingerprints were correlated with the nif and hup genotypes. We found multiple bands of RS-specific hybridization for two isolates that differed from the patterns of the other isolates. These results suggest that RS fingerprinting is a valuable tool for evaluating the genetic structure of indigenous B. japonicum populations.
|
2022-12-19T02:39:07.771Z
|
129,068,337 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/02723646.2000.10642697",
"MAG": "1646536559",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The spatial and temporal variation of the C/D Köppen climate boundary in the central United States is examined for the period 1900 to 1999. Mean January temperature data from the U.S. Historical Climatology Network for 67 sites located between 37°N and 41.5°N latitude and 90°W and 100°W longitude are utilized. The variation of the boundary between the C and D climates (i.e., 26.6°F isoline) is illustrated for the entire 100-year study period and four quarter-century periods, as well as for individual decades (1900s, 1910s, …, 1980s, 1990s). For the quarter-century climatic periods, the latter two (1950 to 1974, 1975 to 1999) had C/D boundaries farther south (implying “colder” winters) compared to the positions for the first two quarter-century periods. The most anomalous feature for the decadal maps is the distinct southerly location of the C/D boundary for the recent decade of the 1970s. Although the C/D boundaries for the decades of the 1980s and 1990s generally are located slightly north of the 100-year overall mean location (implying “warmer” than average winter conditions), several earlier decades (e.g., 1900s, 1920s, 1930s) had even more northerly positions. Therefore, this study does not provide evidence of a trend toward wintertime warming and a northerly migration of the C/D climate boundary within the central United States. [Key words: climate change, climate classification.]
|
2022-12-19T06:22:12.728Z
|
42,605,482 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/10400435.2015.1074631",
"MAG": "1787751852",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT Powered wheelchairs are complex and expensive assistive devices that must be selected and configured on the basis of individual user needs, lifestyle, motivation, driving ability, and environment. Providing agencies often require evidence that their financial investment will lead to a successful outcome. The authors surveyed a sample of 79 users who had obtained powered wheelchairs from a Regional Health Service in Italy in the period 2008–2013. Follow-up interviews were conducted at the users’ homes in order to collect information about wheelchair use, and its effectiveness, usefulness, and economic impact. The instruments used in the interviews included an introductory questionnaire, QUEST (Quebec User Evaluation of Satisfaction with Assistive Technology), PIADS (Psychosocial Impact of Assistive Devices Scale), FABS/M (Facilitators and Barriers Survey/Mobility), and SCAI (Siva Cost Analysis Instrument). The results indicated positive outcomes, especially in relation to user satisfaction and psychosocial impact. A number of barriers were identified in various settings that sometimes restrict user mobility, and suggest corrective actions. The provision of a powered wheelchair generated considerable savings in social costs for most users: an average of about $38,000 per person over a projected 5-year period was estimated by comparing the cost of the intervention with that of non-intervention.
|
2022-12-19T12:01:31.311Z
|
252,671,649 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1101/2022.09.30.509517",
"MAG": null,
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},
"license": "CCBYNCND",
"status": "GREEN",
"url": "https://www.biorxiv.org/content/biorxiv/early/2022/10/01/2022.09.30.509517.full.pdf"
}
|
Insertions and deletions (indels) are common sources of structural variation, and insertions originating from spontaneous DNA lesions are frequent in cancer. We developed a highly sensitive assay in human cells (Indel-Seq) to monitor rearrangements at the TRIM37 acceptor locus which reports indels stemming from experimentally-induced and spontaneous genome instability. Templated insertions derive from sequences genome-wide and are enriched within 100 kb of donor regions flanking a DSB. Insertions require contact between donor and acceptor loci as well as DNA-PK catalytic activity. Notably, these templated insertions originate from actively transcribed loci, underscoring transcription as a critical source of spontaneous genome instability. Transcription-coupled insertions involve a DNA/RNA hybrid intermediate and are stimulated by DNA end-processing. Using engineered Cas9 breaks, we establish that ssDNA overhangs at the acceptor site greatly stimulate insertions. Indel-Seq revels that insertions are generated via at least three distinct pathways. Our studies indicate that insertions result from movement and subsequent contact between acceptor and donor loci followed invasion or annealing, then by non-homologous end-joining at the acceptor site.
|
2022-12-25T17:09:30.823Z
|
143,021,677 |
{
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"ArXiv": null,
"DOI": "10.1002/(SICI)1099-1166(199809)13:9<638::AID-GPS837>3.0.CO;2-N",
"MAG": "1969646587",
"PubMedCentral": null
},
"license": null,
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"url": null
}
|
Pica is the persistent, culturally and developmentally inappropriate ingestion of non‐nutritive substances (DSM‐IV). AB is a 75‐year‐old lady with a 40‐year history of schizophrenia and a 20‐year history of pica who, at emergency laparotomy, had £175·32 of loose change in her stomach. Although pica has been reported to coexist with schizophrenia, she had had no positive symptoms of schizophrenia for at least 20 years. She has CT evidence of frontotempotal atrophy most marked on the left in the temporal lobe and on the right in the frontal lobe. Pica has been found to be related to cognitive deficits and hyperoral behaviour to temporal lesions. Neuropsychological testing reveals deficits closely related to these changes. © 1998 John Wiley & Sons, Ltd.
|
2022-06-18T18:58:15.863Z
|
42,067,898 |
{
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"ArXiv": null,
"DOI": "10.1039/B416072J",
"MAG": "2040258026",
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},
"license": null,
"status": null,
"url": null
}
|
An ordered zeolite MFI film has been prepared on the substrate of a {001} basal face of high-quality large silicalite-1 crystals by epitaxial growth.
|
2022-09-06T11:24:35.701Z
|
125,841,049 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.23860/diss-estabrooks-chad-2018",
"MAG": "2806674160",
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},
"license": "CCBY",
"status": "HYBRID",
"url": "https://digitalcommons.uri.edu/cgi/viewcontent.cgi?article=1733&context=oa_diss"
}
|
We investigate a relationship between escape regions in slices of the parameter space of cubic polynomials. The focus of this work is to give a precise description of how to obtain a topological model for the boundary of an escape region in the slice consisting of all cubic polynomials with a marked critical point belonging to a two cycle. To obtain this model, we start with the unique escape region in the slice consisting of all maps with a fixed marked critical point, and make identifications which are described using the identifications which are made in the lamination of the basilica map z 7→ z − 1.
|
2022-11-23T18:05:56.768Z
|
226,958,005 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1590/0100-69912017002015",
"MAG": "2704916354",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "http://www.scielo.br/pdf/rcbc/v44n2/0100-6991-rcbc-44-02-00109.pdf"
}
|
. In Brazil it accounts for 2% of all types of neoplasias and for 4% of all cancer deaths. Although not among the top ten cancers in Brazil, it is the eighth leading cause of cancer death, since most patients are diagnosed in locally advanced or metastatic disease stages. Nevertheless, it holds the 13th position in incidence by type of cancer in the rankings made by the National Cancer Institute of the Brazilian Ministry of Health
|
2022-12-21T06:21:40.053Z
|