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136,752,850 |
{
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"ArXiv": null,
"DOI": "10.3379/TMJPN2001.3.109",
"MAG": "2062772613",
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|
Magnetic tunnel junctions (MTJs) consisting of GdFe/Al oxide/Co/TbFe layers were fabricated. The GdFe and TbFe layers were perpendicularly magnetized, and the TbFe and Co layers were exchange-coupled with each other. Magnetoresistance (MR) curves were measured for MTJs with Co layers of various thicknesses while applying a field perpendicular to the film plane. The MR ratio showed a maximum of 12.1% when the Co layer thickness was 0.5 nm. Calculation using a noncontinuum model showed that the direction of the Co magnetization in the exchange-coupled film was perpendicular to the film plane when the thickness of the Co layer was less than 0.4 nm, which was consistent with measured magnetization curves as well as the results of simulation.
|
2022-02-09T10:58:30.944Z
|
144,996,836 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.17730/HUMO.32.4.X22881053860V202",
"MAG": "2070292278",
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"status": null,
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|
This study investigated the orientation of the extension services in the Western State of Nigeria, using the attitudes and role performance of the divisional extension officers as indicators of that orientation. John Miner's (1968) model of organizational behavior and a two-dimensional scheme of organizational orientation were used as theoretical frameworks.Contrary to the hypothesis that public service organizations behave in a way to facilitate their maintenance and survival, the findings revealed that the government extension services behaved in a way to promote education and development. This behavioral orientation is, however, limited by insufficient resources. Suggestions are made for a reexamination of priorities and improved management of the scarce resources available. The usefulness of the theoretical framework adopted in this study for understanding organizational behavior is also demonstrated.
|
2022-09-14T10:13:00.923Z
|
9,275,762 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4274/jcrpe.v3i2.11",
"MAG": "1582707002",
"PubMedCentral": "3119440"
},
"license": "CCBYNCND",
"status": "GOLD",
"url": "https://doi.org/10.4274/jcrpe.v3i2.11"
}
|
Thyroid hormones regulate growth by several mechanisms. In addition to their negative feedback effect on the stimulatory hormones thyrotropin-releasing hormone (TRH) and thyrotropin (TSH), thyroid hormones also regulate their receptors in various physiological and pathological conditions. Up-regulation and down-regulation of the thyroid receptors fine-tune the biological effects exerted by the thyroid hormones. Interestingly, the deiodinase enzyme system is another intrinsic regulator of thyroid physiology that adjusts the availability of thyroid hormones to the tissues, which is essential for normal growth and development. Almost all chronic diseases of childhood impair growth and development. Every disease may have a unique mechanism to halt linear growth, but reduced serum concentration or diminished local availability of thyroid hormones seems to be a common pathway. Therefore, the effects of systemic diseases on thyroid physiology must be taken into consideration in the evaluation of growth retardation in affected children. Conflict of interest:None declared.
|
2022-12-12T11:53:56.640Z
|
114,349,618 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1002/eqe.2767",
"MAG": "2408891694",
"PubMedCentral": null
},
"license": "publisher-specific, author manuscript",
"status": "BRONZE",
"url": "https://rss.onlinelibrary.wiley.com/doi/am-pdf/10.1002/eqe.2767"
}
|
In an attempt to quantify the conductor cable effect on substation electrical equipment, real‐time hybrid simulation (RTHS) is conducted on interconnected equipment using two shaking tables. For this purpose, the existing RTHS system with advanced control capabilities at the Pacific Earthquake Engineering Research Center structural laboratory is enhanced to accommodate the simultaneous use of two shaking tables. An experimental parametric study is conducted to investigate the conductor cable effect using this system with a two‐table RTHS setup. Post insulators of disconnect switches, important components of substations that are usually tested with conventional methods for evaluating their seismic performance, are utilized as experimental substructures for realistic representation of the electrical equipment. Various global and local response parameters, including accelerations, forces, displacements, and strains, are considered to evaluate the effect of the tested conductor cable configuration for a wide range of support structure configurations, which are modeled in the computer as analytical substructures. The experimental parametric study results indicate that the conductor cable has a significant effect on the response of the interconnected equipment over the whole range of investigated support structures and needs to be explicitly considered for seismic testing of electrical equipment. Copyright © 2016 John Wiley & Sons, Ltd.
|
2022-12-20T12:52:04.358Z
|
108,451,799 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1680/IJOTI.1949.12943",
"MAG": "1997920698",
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},
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"status": null,
"url": null
}
|
Synopsis. Works for the intake of water from rivers in India for waterworks, power stations, and textile factories have to be designed to cope with the extreme variations in the flow conditions in such rivers; in fact, during the dry season it is often exceedingly difficult to obtain an adequate supply without sustaining heavy recurring expenditure. Several types of intake in general use are mentioned in the Paper, and it is shown that some are very inefficient when judged by their ability to admit the cleanest water during the monsoon and sand-free water during the dry season. These factors have to be considered in addition to head losses between river-level and the pumps, since, apart from the additional wear and tear in the pumping plant, the disposal of great quantities of silt and sand from the settling tanks at a large works over period of years can become quite a serious problem. In the latter part of the Paper a new type of intake is described, and it is claimed that, when used under suitable cond...
|
2022-01-27T09:38:31.915Z
|
143,416,336 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1353/jhi.0.0042",
"MAG": "1966173667",
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},
"license": null,
"status": null,
"url": null
}
|
This essay explores the connections between Karl Polanyi's The Great Transformation (1944) and midcentury social theory in the United States. It argues that Polanyi shared with his U.S. colleagues a critique of market society. In particular, Polanyi's work bears close resemblance to the early thought of management theorist Peter Drucker, with whom Polanyi lived while writing his celebrated book. By comparing Polanyi to his contemporaries who advanced similar ideas, one gains a clearer sense of the particularities of Polanyi's project and of the fairly widespread movement in the United States to reject economistic thinking.
|
2022-11-13T04:22:44.737Z
|
221,188,002 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2196/17340",
"MAG": "3044155030",
"PubMedCentral": "7413277"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.jmir.org/2020/7/e17340/PDF"
}
|
Background Noncommunicable diseases (NCDs) have become the main public health concern worldwide. With rapid economic development and changes in lifestyles, the burden of NCDs in China is increasing dramatically every year. Monitoring is a critical measure for NCDs control and prevention. However, because of the lack of regional representativeness, unsatisfactory data quality, and inefficient data sharing and utilization, the existing surveillance systems and surveys in China cannot track the status and transition of NCDs epidemic. Objective To efficaciously track NCDs epidemic in China, this pilot program conducted in Ningbo city by the Chinese Center for Disease Control and Prevention (CDC) aimed to develop an innovative model for NCDs surveillance and management: the integrated noncommunicable disease collaborative management system (NCDCMS). Methods This Ningbo model was designed and developed through a 3-level (county/district, municipal, and provincial levels) direct reporting system based on the regional health information platform. The uniform data standards and interface specifications were established to connect different platforms and conduct data exchanges. The performance of the system was evaluated based on the 9 attributes of surveillance system evaluation framework recommended by the US CDC. Results NCDCMS allows automatic NCDs data exchanging and sharing via a 3-level public health data exchange platform in China. It currently covers 201 medical institutions throughout the city. Compared with previous systems, automatic popping up of the report card, automatic patient information extraction, and real-time data exchange process have highly improved the simplicity and timeliness of the system. The data quality meets the requirements to monitor the incidence trend of NCDs accurately, and the comprehensive data types obtained from the database (ie, directly from the 3-level platform on the data warehouse) also provide a useful information to conduct scientific studies. So far, 98.1% (201/205) of medical institutions across Ningbo having been involved in data exchanges with the model. Evaluations of the system performance showed that NCDCMS has high levels of simplicity, data quality, acceptability, representativeness, and timeliness. Conclusions NCDCMS completely reshaped the process of NCD surveillance reporting and had unique advantages, which include reducing the work burden of different stakeholders by data sharing and exchange, eliminating unnecessary redundancies, reducing the amount of underreporting, and structuring population-based cohorts. The Ningbo model will be gradually promoted elsewhere following this success of the pilot project, and is expected to be a milestone in NCDs surveillance, control, and prevention in China.
|
2022-11-27T18:53:50.055Z
|
109,879,113 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4271/2007-01-3177",
"MAG": "1585977137",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Water recovery from wastewater is essential for the success of long-term missions to the Moon and Mars and human crew operations during explorations of these planets. Honeywell International and the team consisting of Thermodistillation Co. ( Kyiv, Ukraine) and NASA JSC Crew and Thermal Systems Division are developing an efficient wastewater processing subsystem that is based on centrifugal vacuum distillation. This subsystem will be tested at the NASA JSC Advanced Water Recovery Systems Development Facility. The Wastewater Processing Cascade Distillation Subsystem (CDS) utilizes an innovative and proven multi-stage thermodynamic process to produce purified water efficiently, and its rotary centrifugal design provides gas/liquid phase separation and liquid transport (pumping) under microgravity conditions. Key performance and success criteria for the subsystem design are: water production rate of 5 kg/hr max., specific power consumption at less than -140 W/kg, and the successful operation of the technology at NASA-JSC. The system will operate in automatic mode and the control algorithms have been formulated and tested experimentally.
|
2022-12-10T09:47:43.352Z
|
43,549,670 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1364/OFC.2012.OW4F.6",
"MAG": "2088088869",
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},
"license": null,
"status": null,
"url": null
}
|
Control of chirp parameter in a fully integrated EML-SOA chip based on InGaAlAs MQW technology is investigated. Transmission at 10 Gbit/s over 100 km of conventional SMF was obtained by optimizing signal chirp at emission.
|
2022-12-15T07:45:39.427Z
|
49,188,926 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3892/mmr.2018.9164",
"MAG": "2808172242",
"PubMedCentral": "6072182"
},
"license": "CCBYNCND",
"status": "HYBRID",
"url": "https://www.spandidos-publications.com/10.3892/mmr.2018.9164/download"
}
|
Diabetic nephropathy (DN) is a serious complication of diabetes and can cause an increased mortality risk. It was previously reported that NLR family pyrin domain containing 3 (NLRP3) inflammasome is involved in the pathogenesis of diabetes. However, the underlying mechanism is not clearly understood. In the present study, the effects of spleen tyrosine kinase (Syk) and c-Jun N-terminal kinase (JNK) on the NLRP3 inflammasome were examined in vivo and in vitro. Sprague-Dawley rats were injected intraperitoneally with streptozotocin (65 mg/kg) to induce diabetes. HK2 cells and rat glomerular mesangial cells (RGMCs) were examined to detect the expression of JNK and NLRP3 inflammasome-associated proteins following treatment with a Syk inhibitor or Syk-small interfering (si)RNA in a high glucose condition. In the present study, it was revealed that the protein and mRNA expression levels of NLRP3 inflammasome-associated molecules and the downstream mature interleukin (IL)-1β were upregulated in vivo and in vitro. The Syk inhibitor and Syk-siRNA suppressed high glucose-induced JNK activation, and subsequently downregulated the activation of the NLRP3 inflammasome and mature IL-1β in HK2 cells and RGMCs. Furthermore, high glucose-induced apoptosis of HK2 cells was reduced by the Syk inhibitor BAY61-3606. Therefore, the present results determined that high glucose-induced activation of the NLRP3 inflammasome is mediated by Syk/JNK activation, which subsequently increased the protein expression level of IL-1β and mature IL-1β. The present study identified that the Syk/JNK/NLRP3 signaling pathway may serve a vital role in the pathogenesis of DN.
|
2022-12-21T15:13:33.999Z
|
171,013,065 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.18317/KADER.86554",
"MAG": "1905427224",
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"license": null,
"status": null,
"url": null
}
|
As it's known, tradition of classifying sciences had started with Aristotle in Ancient Greek, who had classified sciences in his philosophical works as theoretical, practical and poetic and his views had been continued and developed by neoplatonic philosophers and medieval Muslim thinkers . Especially, the medieval Muslim thinkers did not just received this classification, but also improved it to discover new scientific fields. Among medieval Muslim thinkers, attempts to classify the sciences began as early as the third/ninth century with C?bir ibn Hayy?n and was developed thereafter by al-Khw?rizm? , al-Kind ? , Abu Nasr al-F ? r ? b ? , Avicenna, al-Ghazal ? etc.. Muslim thinkers’ classification of science is important in, showing the topics, contents, methods, values and hierarchical relations of sciences with each other. Also it expresses understanding of the thinkers general epistemology and epistemology of science, point of view, and handling the topics. This article is about Ibn Abd al-Barr’s classification of sciences within the framework of his epistemological foundations. For this reason, in this study, we aim to analyse Ibn Abd al-Barr’s epistemology and classification of sciences and show their relationship with each other and compare his classification of sciences other Muslim thinkers’ classifications.
|
2022-02-08T17:04:12.742Z
|
58,672,685 |
{
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"ArXiv": null,
"DOI": "10.1109/IEDM.2018.8614657",
"MAG": "2913016521",
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},
"license": null,
"status": null,
"url": null
}
|
As one of the most important technologies in the coming “More than Moore” era, neuromorphic computing critically depends on the development of synaptic devices. Here we take advantage of the synergy of the strong broadband optical absorption of boron (B)-doped silicon nanocrystals (Si NCs) and the efficient charge transport of two-dimensional (2D) WSe2 to make synaptic devices based on the hybrid structure of Si NCs and 2D WSe2. The Si-NC/WSe2 synaptic devices can be optically stimulated in a broad spectral region from the ultraviolet (UV) to near-infrared (NIR), exhibiting important synaptic functionalities. The energy consumption of the Si-NC/WSe2 synaptic devices may be as low as ∼ 75 fJ. This work has important implication for the development of synaptic devices by exploiting the abundant library of semiconductor NCs and 2D materials.
|
2022-12-29T19:19:17.448Z
|
213,831,918 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.21883/ftt.2020.03.48995.446",
"MAG": "3007720887",
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},
"license": null,
"status": "GOLD",
"url": "https://journals.ioffe.ru/articles/viewPDF/48995"
}
|
The comprehensive experimental and theoretical study of the processes of local ordering of multicomponent alloys was carried out. Experimental techniques included atom-probe tomography and measurement of electrical resistivity during isochronal annealing. The theoretical study was carried out by atomistic modeling methods. The evolution of the system was described in the framework of the multiscale paradigm which is based on quantum-mechanical calculations. The initial stage of the decomposition of a solid solution of CoCrFeNi alloy with the formation of Ni4Cr and Ni2Cr precipitations was demonstrated for the first time by the employed approach.
|
2022-01-27T17:38:12.135Z
|
194,381,922 |
{
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"ArXiv": null,
"DOI": "10.24045/SC.2017.1.8",
"MAG": "2604668513",
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},
"license": null,
"status": null,
"url": null
}
|
In the article the author considers the technology of shocking performance art, kitsch, as controls mass culture of everyday life. Created and described the questionnaire for the sociological survey on the impact of entertainment technologies on popular culture, for example, the Madonna's show in Saint-Petersburg. Discusses the influence of technologies (during the concert program of Madonna) on the audience, the impact of the actions on the behavior management and further emotions. The questionnaire includes questions on personal data of the respondents, about what forms of leisure they prefer, how to meet their cultural preferences, how popular culture affects society, which is the dominant personality in show business. The survey, its outcomes and conclusions are given in the article.
|
2022-02-08T08:15:36.492Z
|
90,902,934 |
{
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"ArXiv": null,
"DOI": "10.1182/BLOOD.V124.21.3770.3770",
"MAG": "2583576401",
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},
"license": null,
"status": null,
"url": null
}
|
Overall survival rates for children with Acute Lymphoblastic Leukemia (ALL), the most common type of leukemia in children, are approaching 90% (Mullighan 2013). In the past 5 years, genome wide approaches, studying DNA copy number alterations in ALL, have increased the list of risk stratifications and included IKZF1 deletions to the list of unfavorable prognostic factors. IKZF1 deletions can be identified in approximately 70% of the Philadelphia chromosome-positive (Ph + ) and in 15% of the Philadelphia chromosome-negative (Ph - ) children with ALL and are associated with an increased risk on relapse and a decreased overall survival (Mullighan 2009, Kuiper 2010, van der Veer 2013). IKZF1 deletions observed in B-cell precursor ALL (BCP-ALL) are typically mono-allelic, resulting in the expression of a dominant-negative isoform (Mullighan 2008). A unique gene expression signature was revealed in IKZF1 deleted BCP-ALL patients, characterized by the downregulation of genes regulating B-cell lineage development and DNA repair upon DNA damage response genes and upregulation of cell cycle/apoptosis genes, JAK/STAT signaling and stem cell self-renewal (Iacobucci 2012). At the level of signal transduction, western blot analysis showed that IKZF1 deletions resulted in B cell receptor (BCR) signaling defects and upregulation of phospho-STAT5 in 2 and 4 Ph + ALL patients, respectively (Trageser 2009, Iacobucci 2012). However, effects of IKZF1 deletions on signaling pathways in Ph - ALL have not been extensively studied. Pediatric Ph - BCP-ALL patients (N=46) were screened for IKZF1 deletions by multiplex ligation-dependent probe amplification analysis. A total of 15 patients carried an IKZF1 deletion. We performed a kinase activity profile ( IKZF1 deleted N=15, IKZF1 wild type N=31) as well as a human phospho-proteome array ( IKZF1 deleted N=11, IKZF1 wild type N=17) to elucidate active signal transduction pathways. Kinase activity profiling is a potent high throughput technique using peptides of 11 amino acids in length representing known human phosphorylation sites. In the obtained kinase activity profiles we studied differences in peptide phosphorylation intensities. 37 peptides were differentially expressed between IKZF1 deleted and wild type pediatric Ph - BCP-ALL patients ( P ≤ 0.05, Figure 1). From these 37 peptides we first examined peptides derived from proteins involved in the BCR signaling and STAT5. On the kinome array, peptides derived from Src_Y352, CBL_Y371, SYK_Y526, PLCg2_Y753, PLCg2_Y1217, STAT5a_S780, STAT5a_Y694, and STAT5b_Y679 were present but showed no differences in phosphorylation intensities between IKZF1 deleted and IKZF1 wild type Ph - BCP-ALL samples. Neither could we detect differences in phosphorylation intensities of Fyn_Y420, Lyn_Y397, Src_Y419, STAT5a_Y694, STAT5b_Y699, and STAT5a/b_Y694/Y699 using human phospho-proteome arrays, confirming the kinome profiling results. We did, however observe a distinct kinome profile upon hierarchical clustering of 46 BCP-ALL primary samples, based on the 37 peptides identified by t-test (Figure 1). IKZF1 deleted cases showed high phosphorylation of 14 peptides including peptides derived from Akt1_Y326 and Cav1_Y14 (Figure 1). Loss of IKZF1 has been associated with glucocorticoid resistance. Since Akt inhibition reverses glucocorticoid resistance in T cell ALL (Piovan, 2013) and Caveolin 1 is involved in focal adhesion and chemoresistance (Faggi, 2014) we hypothesize that Akt and Caveolin 1 inhibition might convert glucocorticoid resistance in Ph - IKZF1 deleted pediatric BCP-ALL, which requires further investigation. Together, we conclude that kinome profiling revealed a distinct peptide phosphorylation pattern for IKZF1 deleted pediatric Ph - BCP-ALL including novel therapeutic targets. Disclosures No relevant conflicts of interest to declare.
|
2022-02-10T18:39:36.379Z
|
4,552,235 |
{
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"DOI": "10.3389/fonc.2018.00093",
"MAG": "2795941895",
"PubMedCentral": "5891588"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.frontiersin.org/articles/10.3389/fonc.2018.00093/pdf"
}
|
While the use of next-generation androgen receptor pathway inhibition (ARPI) therapy has significantly increased the survival of patients with metastatic prostate adenocarcinoma (AdPC), several groups have reported a treatment-resistant mechanism, whereby cancer cells can become androgen receptor (AR) indifferent and gain a neuroendocrine (NE)-like phenotype. This subtype of castration-resistant prostate cancer has been termed “treatment-induced castration-resistant neuroendocrine prostate cancer” (CRPC-NE). Recent reports indicate that the overall genomic landscapes of castration-resistant tumors with AdPC phenotypes and CRPC-NE are not significantly altered. However, CRPC-NE tumors have been found to contain a NE-specific pattern throughout their epigenome and splicing transcriptome, which are significantly modified. The molecular mechanisms by which CRPC-NE develops remain unclear, but several factors have been implicated in the progression of the disease. Recently, Ser/Arg repetitive matrix 4 (SRRM4), a neuronal-specific RNA splicing factor that is upregulated in CRPC-NE tumors, has been shown to establish a CRPC-NE-unique splicing transcriptome, to induce a NE-like morphology in AdPC cells, and, most importantly, to transform AdPC cells into CRPC-NE xenografts under ARPI. Moreover, the SRRM4-targeted splicing genes are highly enriched in various neuronal processes, suggesting their roles in facilitating a CRPC-NE program. This article will address the importance of SRRM4-mediated alternative RNA splicing in reprogramming translated proteins to facilitate NE differentiation, survival, and proliferation of cells to establish CRPC-NE tumors. In addition, we will discuss the potential roles of SRRM4 in conjunction with other known pathways and factors important for CRPC-NE development, such as the AR pathway, TP53 and RB1 genes, the FOXA family of proteins, and environmental factors. This study aims to explore the multifaceted functions of SRRM4 and SRRM4-mediated splicing in driving a CRPC-NE program as a coping mechanism for therapy resistance, as well as define future SRRM4-targeted therapeutic approaches for treating CRPC-NE or mitigating its development.
|
2022-02-13T11:41:27.009Z
|
162,921,504 |
{
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"ArXiv": null,
"DOI": "10.2307/2493068",
"MAG": "2123707910",
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},
"license": null,
"status": null,
"url": null
}
|
Although much more purely descriptive than Hodnett's study, the chapter by Morris is to be commended for its breadth of perspective and coverage of all the relevant aspects of the data analyzed, and for sobriety of interpretation and style. It also contains interesting factual and comparative nuggets, such as the observation that the role of Guinea, Ghana, and Mali at the Twenty-second Congress bears a significant similarity to the association of the Kuomintang with the Comintern during the 1920s. Morris's not uncritical but qualifiedly positive evaluation of Khrushchev's policy line contrasts sharply with the more negative evaluation of the ebullient Nikita presented, in different contexts, by Conquest, Blake, and Hazard. Conquest, in particular, appears to be concerned lest his readers be "taken in" by Khrushchev's image-building efforts, as well as those of his successors. In this reviewer's opinion, the at times highly colored and occasionally even abusive language used by Conquest may have the effect of irritating rather than convincing a sophisticated reader. Blake's brilliantly written chapter is perhaps most useful for its sensitive rendering of nuances of politically relevant sentiments of Soviet writers. This reviewer recommends Politics in the Soviet Union as useful, for reference and for varied and stimulating interpretations, both to experts and to undergraduate and graduate students. As a pedagogical tool, however, it has been superseded by other books, some by a single author and some of a collective type with greater unity of content, structure, and perspective.
|
2022-08-11T12:44:39.234Z
|
39,459,586 |
{
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"ArXiv": null,
"DOI": "10.1080/09595230410001645583",
"MAG": "2064048960",
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},
"license": null,
"status": null,
"url": null
}
|
This paper reports on the evaluation of the implementation of the National Recommendations for the Clinical Management of Alcohol-Related Problems in Indigenous Primary Care Settings undertaken in 2001 through 74 standardized workshops, which sought to determine: (1) whether this approach to implementation influenced the likelihood that the National Recommendations would be used; (2) whether it influenced participants' willingness to engage with Indigenous patients regarding alcohol-related issues; and (3) whether the implementation as a whole influenced both practice and clinicians' willingness to engage. Evaluation included pre-/post-workshop and follow-up questionnaires and a focus group. The findings presented indicate that distribution of clinical resources alone is not sufficient to ensure use and that, particularly for medical practitioners, appropriate introduction not only increases use but also positively influences willingness to engage with alcohol-related problems as part of primary clinical care. Further, the enthusiasm for guideline production should be tempered by the need to develop effective implementation strategies.
|
2022-09-08T07:15:04.979Z
|
60,881,880 |
{
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"DOI": "10.1109/SSST.2002.1027085",
"MAG": "1938440182",
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"license": null,
"status": null,
"url": null
}
|
Narrow bursts of laser pulses have many applications. OFID is one of the techniques used to shorten the pulsewidth of a CO2 laser after it passes through a gas such as Dymel. Present work is an extension of earlier studies in Dymel gas. Controlled mixtures of Dymel with Helium, Argon, and Nitrogen gas affect the original OFID effect in pure Dymel gas in different ways.
|
2022-09-15T16:30:35.809Z
|
204,689,907 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.21733/ibad.612184",
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},
"license": null,
"status": "GOLD",
"url": "https://dergipark.org.tr/tr/download/article-file/855840"
}
|
Sagligi etkileyen ve kotulesen bir cevre ekonomik faaliyetler uzerinde olumsuz bir etkiye yol acabilmektedir. Bu calismada cevre kirliliginin ve ekonomik buyumenin saglik harcamalari uzerindeki etkisi ASEAN-5 ulkeleri icin 2000-2014 donemi ele alinarak incelenmistir. Calismada Pedroni, Kao ve panel FMOLS es-butunlesme testleri uygulanmistir. Calisma sonucunda saglik harcamalari, cevre kirliligi ve ekonomik buyume arasinda uzun donemli bir iliski oldugu sonucuna ulasilmistir. Ayrica calismada cevre kirliligi ve ekonomik buyumenin saglik harcamalarini artirdigi bulgusuna da ulasilmistir.
|
2022-10-02T15:57:57.027Z
|
119,005,026 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1063/1.3149464",
"MAG": "1529352757",
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"license": null,
"status": null,
"url": null
}
|
The ASI Science Data Center (ASDC) has developed an X‐ray event simulator to support users (and team members) in simulation of data taken with the two cameras on board the Simbol‐X X‐Ray Telescope. The Simbol‐X simulator is very fast and flexible, compared to ray‐tracing simulator. These properties make our simulator advantageous to support the user in planning proposals and comparing real data with the theoretical expectations and for a quick detection of unexpected features. We present here the simulator outline and a few examples of simulated data.
|
2022-01-27T03:09:38.986Z
|
110,680,350 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4271/891588",
"MAG": "2116217768",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A ground based facility for the study of plant growth and development under stringently controlled environments is being developed by the Closed Ecological Life Support System (CELSS) program at the Ames Research Center. Several Crop Growth Research Chambers (CGRC) and laboratory support equipment provide the core of this facility. The CGRC is a closed (sealed) system with a separate recirculating atmosphere and nutrient delivery systems. The atmospheric environment, hydroponic environment, systems controls, and data acquisition are discussed.
|
2022-02-10T04:51:20.614Z
|
109,499,934 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/BATE.200710001",
"MAG": "1994765998",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Kämpf‐Stegträger wie die der Eissporthalle in Bad Reichenhall wurden, wenn auch meist in geringeren Dimensionen, in den 1950er und 1960er Jahren vielfach eingesetzt. Sie sind ein Beispiel für die großen Anstrengungen, die man in Forschung und Praxis in diesen Jahren unternahm, um die Leimbauweise im Ingenieurholzbau endgültig zu etablieren. Spätestens Ende der 1960er Jahre war dieses Ziel erreicht. Gleichwohl wurden die Ursprünge des Leimbaus bereits ein halbes Jahrhundert früher durch Otto Hetzer und andere gelegt. Und so ist die Entwicklungsgeschichte des Brettschichtholzträgers einmal mehr ein Beispiel dafür, daß der als Diffusion bezeichnete Prozeß – von der Innovation bis zur allgemeinen Verbreitung und Anwendung einer Neuerung – sich gerade im Bauwesen oftmals über ein bis zwei Generationen erstreckt.
|
2022-03-27T10:50:58.868Z
|
13,550,533 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ISANP.2017.8228802",
"MAG": "2772307679",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper propose a stacked ceramic patch antenna that is composed with two ceramic patch antenna for Global Navigation Satellite Systems (GNSS) and Satellite Digital Audio Radio Service (SDARS). The proposed antenna stacks up GNSS antenna on SDARS antenna to reduce the antenna volume without degradation of antenna performances. The proposed antenna covers all of the required gain at the entire azimuth range. The overall volume of proposed antenna is 36×36×9 mm3. The antenna with high performance and minimized structure is a highly marketable product.
|
2022-06-19T16:52:45.929Z
|
149,895,688 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S0021223700008578",
"MAG": "2799369664",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In November 1964 the then Minister of Justice stated in the Knesset: The Members of Knesset surely know that shortly after assuming office I outlined a broad plan to liberate the Israeli law from the shackles of foreign laws and foreign languages. The plan relates first to the Ottoman legislation which is still in force, in particular the civil law compilation known as the Mejelle, and also to Mandatory legislation. The intention is to replace the various chapters of the Mejelle with original Israeli statutes and perhaps later, at a second stage, to unify these statutes with other special statutes in one complete and homogeneous tractate that will serve as an exhaustive civil code.
|
2022-06-23T09:24:44.597Z
|
3,680,927 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4037/ajcc2018467",
"MAG": "2789739168",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "http://ajcc.aacnjournals.org/content/27/2/124.full.pdf"
}
|
&NA; Background Delirium occurs frequently in the intensive care unit and is associated with detrimental consequences. Cognitive training is a promising, nonpharmacologic, preventive intervention, but it is unknown whether cognitive training is feasible for patients in intensive care units. Objectives To examine the feasibility for both nurses and patients of using cognitive training exercises for intensive care unit patients. Methods A pilot study of a set of cognitive training exercises in a large, academic intensive care unit. Feasibility of the exercises, operationalized as practicability and burden for the patient and the nurse, was tested in multiple rounds and evaluated using Likert scales and open‐ended questions, patients' vital signs, and time investment. Results In total, 75 patients were included. During the first round, 11 exercises were separately tested by nursing researchers in 44 cooperative patients (50% with delirium). Four exercises were evaluated as burdensome and were excluded. Vital signs did not alter during execution. In a second round, the remaining exercises were tested in 31 patients (52% with delirium) by their attending nurse. All exercises were rated as practicable and not burdensome by the patients and the nurses. Total time investment per exercise was a median 4.5 (interquartile range, 3.0‐5.0) minutes. Conclusion Cognitive training exercises used in this study were feasible for intensive care unit patients (including cooperative patients with delirium) and their nurses. More research is needed to determine the clinical effect of the exercises on delirium outcome.
|
2022-11-10T18:47:52.388Z
|
7,119,588 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2105/AJPH.78.10.1349",
"MAG": "2026604882",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We examined drug purchases for children less than five years of age from privately owned pharmacies in Matlab, a rural area in Bangladesh. The male to female incidence rate ratio was 1.71 (95 per cent confidence intervals = 1.27, 2.28) for overall drug purchase, and 2.94 (95% CI = 1.14, 7.73) for purchase of drugs prescribed by physicians. Our findings support and extend previous observations in this community of parental son preference in caring for children.
|
2022-12-20T08:00:52.194Z
|
164,868,584 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.31181/DMAME1902076R",
"MAG": "2944085074",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In the present study, a Novel Memetic Genetic Algorithm (NMGA) is developed to solve the Traveling Salesman Problem (TSP). The proposed NMGA is the combination of Boltzmann probability selection and a multi-parent crossover technique with known random mutation. In the proposed multi-parent crossover parents and common crossing point are selected randomly. After comparing the cost/distance with the adjacent nodes (genes) of participated parents, two offspring’s are produced. To establish the efficiency of the developed algorithm standard benchmarks are solved from TSPLIB against classical genetic algorithm (GA) and the fruitfulness of the proposed algorithm is recognized. Some statistical test has been done and the parameters are studied.
|
2022-12-21T01:56:19.986Z
|
543,750 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1084/JEM.166.5.1221",
"MAG": "2085974517",
"PubMedCentral": "2189641"
},
"license": null,
"status": null,
"url": null
}
|
DAF is a 70,000-Mr membrane protein that inhibits the amplification of the complement cascade on the cell surface, and protects cells from damage by complement. The precise mechanism of action of DAF is not entirely clear. Purified DAF was incorporated into the membrane of EAC4b cells. EAC4b2 and EDAF AC4b2 cells were prepared with radiolabeled C2. The same amount of labeled C2 bound to both cells, showing that DAF does not prevent the binding of C2 zymogen to C4b. After adding Cl, the radioactivity of bound C2 dissociated more rapidly from EDAF AC4b cells than from EAC4b cells. In EAC4b cells, bound C2 was converted to C2a, which gradually dissociated into the supernatants. In the DAF-treated cells, on the other hand, a large amount of C2a rapidly appeared in the supernatants and only a small amount of C2a remained on the cells. In a similar experiment using EhuAC4b, DAF on human erythrocyte membrane also dissociated the C2a from the cells. These results were confirmed by hemolytic assay and the accelerated decay of C2a caused the rapid depletion of C2 from the fluid phase. In addition, we found that DAF functions on the alternative pathway C3 convertase, C3bBb in the same manner. Thus, DAF, which associates with C4b and C3b in the membrane, acts on C2a and Bb, but not on intact C2 and B, and dissociates them rapidly from the binding sites, thereby preventing the assembly of the classical and alternative pathways C3 convertases.
|
2022-12-28T15:27:38.029Z
|
128,880,284 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4215/RM2013.1227.0003",
"MAG": "2024188352",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Resumen pt: Esse estudo discute os fatores que explicam a fixacao de migrantes e nao-migrantes em cidades medias dinâmicas do Brasil atual. Considerados os fatores e...
|
2022-01-27T19:57:15.227Z
|
80,264,849 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/BMJ.K1625",
"MAG": "2801597512",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
John Lang Taylor was born in Kenya, the son of a colonial medical officer and a nurse. He was brought up in Stourbridge and went to Old Swinford Hospital School. At St Thomas’ Hospital Medical School he was fly half and captain of rugby in 1975. After …
|
2022-02-11T03:17:18.561Z
|
62,958,162 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1201/9781420042252",
"MAG": "2482871723",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Amazon.com: Complete Crime Scene Investigation Handbook (9781498701440): Everett Baxter Jr.: Books. Complete Crime Scene Investigation Handbook is the most complete, one-stop practical reference for law Private Fashion Private Investigator Books on Investigations training mauals for poilice, private investigators, private detectives Complete Crime Scene Investigation Handbook Practical Homicide Investigation Checklist and Field Guide, Second Edition
|
2022-07-09T01:36:01.722Z
|
126,821,658 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5338/KJEA.2005.24.2.083",
"MAG": "283092556",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This study was conducted to evaluate the influence of pollutant loads on the water quality in the Mankyeong River from January 2002 to December 2004. The BOD level in upstream ranged from 0.58 to 1.57 mg , which would be in I grade according to water quality criteria by Ministry of Environment but BOD level in midstream and downstream was III grade. T-N contents were high in midstream and the average T-P level ranged from 0.06 to 2.70 mg . The point raw loads of BOD was high in Iksancheon, Mokcheonpo and Cheongha basin. The point raw loads of T-N and T-P were high in Iksancheon and Cheongha watershed. The non-point low loads of BOD were 3,931 kg , 2,870 kg and 2,827 kg in Mokcheonpo, Top and Jeonju watershed, respectively. The major source of BOD effluent load was population, that of T-N and T-P effluent loads was livestock. The delivered load of T-N were high in Jeonju, Mokcheonpo, Gosan, Iksancheon watershed in order. The delivered load of T-N was high in Jeonju watershed and that of T-P was high in Jeonju and Iksancheon watershed. The delivery ratio of BOD and T-N at dry season were below 100% except Mokcheonpo watershed. The delivery ratio of BOD and T-N at raining season were high in Gosan watershed.
|
2022-07-19T23:05:45.671Z
|
142,220,415 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.18542/REBAC.V9I1.2132",
"MAG": "1496382095",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Skinner (1938) once defined behavior as a proper subset of organismic activities—those that involve commerce with the outside world. Here I reexamine and reformulate Skinner’s definition to make the underlying conceptual framework more explicit. This framework turns out to be partly morphological and to rely on biological concepts of organism and adaptation. I propose a reformulation of Skinner’s definition along these lines, and I underscore the importance of the skin, not only in the life of an organism, but in the very definition of its behavior. Keywords : definition, behavior, environment, organism, boundary.
|
2022-09-12T11:21:54.379Z
|
8,483,189 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1053/j.semvascsurg.2012.08.001",
"MAG": "2034967264",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
All current endovascular aneurysm repair (EVAR) devices have defined limitations that prevent the endovascular therapist from using them to treat all forms of aortoiliac aneurysm disease. Short, angulated infrarenal aortic neck pathology, occlusive disease in iliac access arteries, need for preservation of important branch vessel arterial flow, endograft migration, and endoleak all represent major impediments for successful EVAR. Need for secondary intervention after EVAR in a significant number of patients has detracted from universal acceptance for this therapy. New devices in manufacturers' pipelines may provide solutions for many of the current EVAR device deficiencies. As these new devices become more complex, meticulous patient follow-up to verify anticipated outcomes and new training paradigms for the future endovascular therapist will be required.
|
2022-09-14T13:10:22.195Z
|
241,931,603 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.20873/uft.2526-8031.2019v3n2p18",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBYNC",
"status": "GOLD",
"url": "https://sistemas.uft.edu.br/periodicos/index.php/atura/article/download/7314/16195"
}
|
RESUMO
Seguindo a perspectiva de invenção de tradições de Eric Hobsbawm (2012) que, na contemporaneidade, conta com o discurso midiático como um elemento constitutivo do imaginário social, que produzimos esse artigo. Desse modo, apresentamos e discutimos três narrativas sobre a Aldeia TabokaGrande e eventos carnavalescos, no distrito Taquaruçu, da capital tocantinense, Palmas. As frentes que constroem o território discursivo são as do próprio produtor do evento, criador e idealizador da Aldeia, a dos moradores de Taquaruçu e o discurso midiático. Para tanto, se vale de uma criatividade metodológica com uso de Análise de Conteúdo, Análise de Discurso, Entrevistas semi-estruturadas e Análise de Discurso do Sujeito Coletivo e encontra semelhanças e diferenças dessas frentes discursivas, demonstrando como há projetos distintos para narrativa da recente história de Taquaruçu, Palmas e Tocantins.
PALAVRAS-CHAVE: Disputa Narrativa; Discurso Midiático; Carnaval de Taquaruçu.
ABSTRACT
From the perspective of invention of traditions of Eric Hobsbawm (2012) who relies on media discourse as a constitutive element of social imaginary in contemporary times, this article was developed. Thereby, we present and discuss three narratives about the Aldeia TabokaGrande and carnival events in the Taquaruçu district of the Tocantins capital, Palmas. The fronts that build the discursive territory are those of the event's own producer, creator and creator of the Aldeia, the residents of Taquaruçu and the media discourse. To this end, it uses methodological creativity using Content Analysis, Discourse Analysis, Semi-structured Interviews and Collective Subject Discourse Analysis and finds similarities and differences in these discursive fronts, demonstrating how there are distinct projects for the narrative of recent history of Taquaruçu, Palmas and Tocantins.
KEYWORDS: Narrative Dispute; Media speech; Taquaruçu Carnival.
RESUMEN
Siguiendo la perspectiva de invención de tradiciones de Eric Hobsbawn (2012) que, en la contemporaneidad, cuenta con el discurso mediático como un elemento constitutivo del imaginario social, producimos este artículo. Deste modo, presentamos y discutimos tres narrativas acerca del pueblo TabokaGrande y eventos carnavalescos en el distrito de Taquaruçu, de la capital de Tocantins, Palmas. Las frentes que constituyen el territorio discursivo son las del propio productor del evento, creador y idealizador del pueblo, la de los moradores de Taquaruçu y el discurso mediático. Para tanto, nos valemos de una creatividad metodológica con el uso de la Análisis de Contenido, Análisis del Discurso, Entrevistas semi-estructuradas y Análisis del Discurso del Sujeto Colectivo, y encuentra semejanças y diferencias entre esas frentes discursivas, demostrando como hay proyectos distintos para la narrativa de la reciente historia de Taquaruçu, Palmas y Tocantins.
PALABRAS CLAVE: Disputa Narrativa;. Discurso Mediático; Carnaval de Taquaruçu.
|
2022-11-11T07:44:07.468Z
|
201,295,277 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/BOOKS978-3-03897-943-2",
"MAG": "2965140051",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Lidar, sodar, radar, and other ground-based remote sensing EO data from SAR, scatterometer and passive microwaves EO-based surface roughness and terrain elevation Remote sensing contribution to wind energy, wind resources, boundary-layer, and wind-power meteorology Remote sensing in atmospheric turbulence and wind-flow modeling Remote sensing in wind tunnels Remote sensing for wake of wind turbines and wind farms Remote sensing application in forecasting of winds and wind power Remote sensing for control of wind turbines and wind farms Remote sensing for the wind turbine blade erosion environment Theoretical and experimental issues within remote sensing for wind energy an Open Access Journal by MDPI
|
2022-11-11T08:10:34.212Z
|
169,156,972 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.36642/mjil.40.3.global",
"MAG": "2913480570",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://repository.law.umich.edu/cgi/viewcontent.cgi?article=1954&context=mjil"
}
|
This Article outlines a “soft-law-to-hard-law” approach for the development and implementation of reforms to systems for the holding of publicly traded securities. It proposes the development of global standards for securities holding systems (“Global Standards”), to be led by the International Organization of Securities Commissions (the “IOSCO”). This approach contemplates that States would be encouraged and expected to implement the Global Standards by adopting “hard law” reforms through statutory and regulatory adjustments to their securities holding systems as well as modifications of the architecture of their securities holding systems. The successes of past IOSCO initiatives inspire this Article’s proposal, as do the relatively successful development and implementation of harmonized standards for supervision and capital adequacy for depository institutions (for example, banks) through the operation of the Basel Committee.
|
2022-11-11T08:25:30.194Z
|
110,390,781 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1115/WTC2005-63594",
"MAG": "2087861153",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The touchdown-takeoff velocity hysteresis observed in hard disk drives during CSS or L/UL tests is analyzed using an experimental approach. Tests similar to L/UL were conducted for different slider-disk combinations at different humidities. Factors affecting the touchdown and takeoff velocity were identified on the basis of their domain of operation. It is concluded that the intermolecular forces and meniscus forces are contributing factors to hysteresis, which is also influenced by disk topography and slider dynamics.Copyright © 2005 by ASME
|
2022-12-12T12:38:06.278Z
|
34,566,730 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3171/2009.5.PEDS08481",
"MAG": "2158761681",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
OBJECT
During recent years, several biomarkers have been introduced for use in the diagnosis of traumatic brain injury (TBI). The primary objective of this investigation was to determine if S100B (or S100 calcium-binding protein B) and neuron-specific enolase (NSE) serum concentrations can effectively be used to discriminate between symptomatic and asymptomatic children with minor head trauma.
METHODS
The authors conducted a prospective clinical study that involved patients age 6 months to 15 years who had sustained minor head trauma. Children with concomitant extracranial injuries were excluded. Blood samples were obtained within 6 hours of injury to measure S100B and NSE levels in serum. The authors defined 2 diagnostic groups: a mild TBI group (patients with Glasgow Coma Scale [GCS] scores of 13-15) in whom there were clinical signs of concussion (short loss of consciousness, amnesia, nausea, vomiting, somnolence, headache, dizziness, or impaired vision) and a head contusion group (patients with a GCS score of 15) in whom symptoms were absent. Both S100B and NSE concentrations were compared between the 2 groups. Secondary end points were defined as follows: correlation of S100B/NSE and a) the presence of scalp lacerations, b) GCS score, c) age, and d) correlation between S100B and NSE.
RESULTS
One hundred forty-eight patients were enrolled (53 in the contusion group, 95 in the mild TBI group). After adjusting for differences in age and time of injury to blood sample withdrawal, there was no significant difference in S100B or NSE between patients in the 2 groups. Scalp lacerations and GCS score had no affect on posttraumatic S100B or NSE concentrations. The correlation between S100B and NSE was significant. Both markers showed a significant negative correlation with age.
CONCLUSIONS
The authors demonstrated that S100B and NSE do not discriminate between symptomatic and asymptomatic children with minor head injury. There seem to be limitations in marker sensitivity when investigating pediatric patients with mild TBI.
|
2022-12-12T22:13:08.727Z
|
196,685,359 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/JFBC.12943",
"MAG": "2951631677",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Many varieties of Triticum aesitivum L. (Bread wheat) and Zea maize L. (maize) have been developed in Pakistan, which are randomly consumed by normal individuals and diabetic patients. In this study, 17 wheat and 9 maize varieties were tested for starch composition, glycemic index, radical scavenging activities, and lipid profile. Among various wheat samples, KPK15 was observed to have highest 2,2-diphenyl-1picrylhydrazyl radical scavenging activity, while CZP132011 was highest radical scavenger among various maize samples. Glycemic index of wheat varieties varied between 62.83 ± 2.19 and 70.70 ± 2.82 in Hashim10 and Insaf, respectively, while for maize it ranged between 56.45 ± 1.95 in Sarhad white and 70.76 ± 4.40 in CHT1W. In most of the varieties, a linear correlation was observed between glycemic index and amylose contents. The data show that KPK15 and Saleem 2000 are the best wheat varieties while Sarhad white is the best among maize samples to be consumed by normal individuals and diabetic patients. PRACTICAL APPLICATIONS: Wheat and maize are the most widely used cereal crops being consumed randomly both by normal individuals and diabetic patients. Diabetes is characterized by hyperglycemia, hyperlipidemia, and high oxidative stress. Diet and nutrition play an important role in the development and control of diabetes. In this research, we attempted to find out the best wheat and maize varieties for diabetic patients from locally grown genotypes.
|
2022-12-19T05:41:51.658Z
|
56,469,397 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1103/PHYSREV.120.300",
"MAG": "2228263733",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Recent observations of angular distributions of $\ensuremath{\pi}$ mesons in $\overline{p}\ensuremath{-}p$ annihilation indicate a deviation from the predictions of the usual Fermi statistical model. In order to shed light on these phenomena, a modification of the statistical model is studied. We retain the assumption that the transition rate into a given final state is proportional to the probability of finding $N$ free $\ensuremath{\pi}$ mesons in the reaction volume, but express this probability in terms of wave functions symmetrized with respect to particles of like charge. The justification of this assumption is discussed. The model reproduces the experimental results qualitatively, provided the radius of the interaction volume is between one-half and three-fourths of the pion Compton wavelength; the dependence of angular correlation effects on the value of the radius is rather sensitive. Quantitatively, there seems to remain some discrepancy, but we cannot say whether this is due to experimental uncertainties or to some other dynamic effects. In the absence of information on $\ensuremath{\pi}\ensuremath{-}\ensuremath{\pi}$ interactions and of a fully satisfactory explanation of the mean pion multiplicity for annihilation, we wish to emphasize the preliminary nature of our results. We consider them, however, as an indication that the symmetrization effects discussed here may well play a major role in the analysis of angular distributions. It is pointed out that in this respect the energy dependence of the angular correlations may provide valuable clues for the validity of our model.
|
2022-12-31T20:59:38.208Z
|
116,304,011 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/WE.2226",
"MAG": "2887281310",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Wind turbine farms suffer from wake losses, where the downstream turbines generate less power, and/or the leading turbines are throttled to reduce the downstream power losses. In this paper, we focus on possible external modifications that can enhance the wind turbines' performance when they are operating in a farm environ-ment. In particular, this study is interested in enhancing the performance of the downstream turbines in wind farms. The idea is to move each turbine's wake down and away from subsequent turbines. This goal is achieved by using stationary external airfoils that are placed in proximity to the rotating blades. A number of different designs are tested and the design concepts are tested using Reynolds ‐ Averaged Navier ‐ Stokes simulations of an aligned array of 2 wind turbines. The turbines are modeled as actuator disks with axial induction and are placed in a velocity field that is modeled as a turbulent atmospheric boundary layer. It is found that fixed external airfoils can enable partial or full power recovery at turbine separations of as small as 3 rotor diameters downstream. We will also demonstrate that some devices can also improve the performance of the upstream turbine. The physical reasons for these power recovery phenomena are discussed.
|
2023-01-01T17:23:36.636Z
|
97,889,022 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/MA970916Z",
"MAG": "2060598334",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Using neutron and light scattering techniques, we studied, as a function of swelling degree in a good solvent, the fluctuations of polymer concentration in highly cross-linked gels prepared in the bulk. Using the method proposed by Pusey and Van Megen, we separated the total scattering intensity into the contributions arising from thermal and quenched fluctuations. The former are equivalent to those measured in an entangled polymer solution with same concentration while the latter are responsible for the excess of intensity scattered from swollen gels and for the typical anisotropic intensity patterns measured on elongated gels. The relaxation of the thermal fluctuations is still governed by the cooperative diffusion of all the chains in the gel, and the associated characteristic length is the screening length for excluded and hydrodynamic interactions. We propose a new picture for fluctuations of concentration in polymer gels and discuss it in relation with recent models.
|
2022-09-10T09:49:15.882Z
|
97,916,113 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1149/1.2789221",
"MAG": "2087747861",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
The speciation of vanadate solutions and the resulting inhibition of oxygen reduction and corrosion of AA2024-T3 were investigated. 51V NMR is very useful for assessing vanadate speciation. Clear metavanadate solutions contain no decavanadate, which forms whenever the pH was decreased by the addition of acid. Orange decavanadate solutions contain no monovanadate, even when the pH is adjusted to high values. Monovanadate is a potent inhibitor in contrast to decavanadate. Inhibition by monovanadate seems to result from an adsorption mechanism rather than reduction. Monovanadate effectively protects S phase particles. Aging of high-pH decavanadate solutions does not improve the inhibition performance or result in complete depolymerization of the decavanadate.
|
2022-12-02T10:36:10.208Z
|
234,007,295 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1556/066.2020.00177",
"MAG": "3133204733",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GREEN",
"url": "https://dea.lib.unideb.hu/dea/bitstream/2437/302141/1/FILE_UP_1_%5b15882535%20-%20Acta%20Alimentaria%5d%20Effect%20of%20nitrogen%20fertiliser%20on%20the%20rate%20of%20lipid%20peroxidation%20of%20different%20maize%20hybrids%20in%20a%20long-term%20multifactorial%20experiment.pdf"
}
|
The presented research aimed to confirm that the differences in the lipid peroxidation of three maize (Zea mays L.) hybrids with different genotypes and maturity are due to different nitrogen levels, which was observed based on the amount of malondialdehyde (MDA) measured in the leaves at the main phenological stages of plants. The experiments were performed in a multi-factorial long term fertilisation field trial. In the study, phosphorus and potassium were constantly provided at the optimal level for the plants. The phosphorus and potassium fertilisation were applied in autumn. However, N levels varied from 0 to 300 kg ha−1. Sampling was done at different growth stages 5 times during the growing season (4 leaves, 6 leaves, 8 leaves, 14 leaves, silking). The 300 kg ha−1 N (dose 3) resulted in a significant increase in lipid peroxidation (MDA level), but not a statistically significant difference between the control (dose 1) and the 120 kg ha−1 (dose 2) N doses. The H1 hybrid had the lowest level of lipid peroxidation at the first sampling date. High volume nitrogen fertilisation (dose 3: 300 kg ha−1) increased lipid peroxidation in the hybrids. Averaging the values obtained for the same hybrid at the different sampling times, the medium (dose 2) 120 kg ha−1 N treatment had no significant effect on the lipid peroxidation of the hybrids compared to the values of the control plants. Based on the lipid peroxidation response of the hybrids to N treatment, the exact N dose inflection point can be determined to make the fertiliser utilisation of plants more efficient. Based on our results, we found that inadequate, low (120 kg ha−1) or high (300 kg ha−1) nitrogen fertilisation could affect the MDA levels of plants, thereby affecting the functioning of the lipid peroxidation mechanism.
|
2022-12-14T22:46:10.760Z
|
137,253,726 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/10426914.2014.966390",
"MAG": "2067110333",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A new method for fabricating CCMPMPs, namely multi-cutter milling, is proposed and the fabrication principle is discussed. Then, a study of three microchannel parameters, the microchannel depth Hc, width Wc, and interval Ws, and two CCMPMP parameters, the porosity P and the total surface area per unit volume SV, is presented. Furthermore, 3D FEM has been adopted to study the effective stress distribution, the metal flow velocity distribution, and the cutting forces. The results show that CCMPMPs can be successfully machined. Hc, Wc, and Ws can be controlled by the radial depth of cut ae, the slotting cutter thickness Et, and the gasket thickness Eg, while P and SV can be changed by adjusting Hc, Wc, and Ws. Moreover, as ae increases, the average resultant force increases, and the friction between chip and the side face of the machined microchannel, and between chip and the rake face, plays an increasingly important role in it.
|
2022-12-15T00:00:54.633Z
|
19,753,491 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2307/3576888",
"MAG": "2068571887",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A technique for the detection of DNA damage induced by radiation insult has been developed. Cells were lysed with a buffer containing 2 M sodium chloride to release the DNA in a supercoiled form, the nucleoid. These were stained with the DNA intercalating dye, ethidium bromide, and exposed to laser light within a flow cytometer. Scattered and fluorescent light was analyzed from the laser/nucleoid interaction following irradiation of viable cells with gamma rays. The addition of ethidium bromide to prepared nucleoids caused a reduction in scattered light due to condensation of the nucleoid. Irradiation of cells prior to nucleoid production and ethidium bromide treatment restricted this condensation and produced a dose-dependent increase in laser scatter. Nucleoids derived from human lymphocytes showed enhanced light scatter from 5 Gy, compared to Chinese hamster ovary (CHO) fibroblasts where doses above 10 Gy were required. Up to 30 Gy CHO nucleoids showed a dose-dependent reduction in the ethidium bromide fluorescence. This technique allows detection of altered light scattering and fluorescent behavior of nucleoids after cellular irradiation; these may be related to structural changes within the nucleus induced by the radiation. The use of flow cytometry compared to other methods allows a rapid analysis of nuclear damage within individual cells.
|
2022-12-21T01:07:28.717Z
|
201,399,632 |
{
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"ArXiv": null,
"DOI": "10.18239/OCNOS_2019.18.2.1961",
"MAG": "2966082686",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Se presenta una propuesta colaborativa entre universidad y escuela para diseñar e implementar en el aula un programa de fluidez lectora basado en evidencias. Participaron 36 alumnos de 2º de Educación Primaria, sus maestras y dos profesores de universidad que actuaron como asesores, constituyendo todos un grupo de trabajo. Se formó a las maestras en contenidos de fluidez y se realizó una evaluación inicial para identificar los grupos de riesgo, emergente y establecido en fluidez lectora. Se diseñó e implementó durante 7 meses un entrenamiento ajustado a cada nivel basado en la lectura repetida de palabras y frases. Los resultados reflejan una mejoría en la competencia de las maestras por la integración del entrenamiento de la fluidez en su sistema de respuesta, adaptándolo a distintos niveles de enseñanza. En el alumnado se constató una mejoría en la fluidez. Se plantea la necesidad de acercar a las escuelas las aportaciones de la investigación educativa y de ayudar a los docentes a desarrollar intervenciones basadas en la misma y ajustadas al nivel del grupo de clase.
|
2022-12-24T10:26:01.029Z
|
95,361,042 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2965/JSWE.20.845",
"MAG": "2033232431",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The characteristics of organic compounds accumulated in bioreactors were examined by using experimental benchscale plants of the activated sludge processs with dead end or cross flow ultrafiltration system.Use of ultrafiltration system brought easily highly concentrated activated sludge suspension in the bioreactors, compared with use of sedimentation system. At the sam time, organic compounds with wide range of molecular weight were accumulated in the bioreactors by introducing ultrafiltration system.Accumulated organic compounds were fractionalized by the gel permeation chromatography using high performance liquid clromatograph(HPLC). A large molecular weight group was composed of organic compounds with a relatively low ratio of E260/TOC, and accumulated predominantly according to treatment performance. A medium molecular weight group was composed of organic compounds with a large ratio of E260/TOC, and molecular weight of the peak was estimated to he about 1,300 on the basis of polyethyleneglycol. A small molecular weight group was also composed of organic compounds with a large ratio of E260/TOC, which might be derived from activated sludge destroyed by the feeding pump to the ultrafiltration membrane module. The small and medium molecular weight groups permeable the membrane in nature was accumulated possibly by dynamic membrane developed on the membrane.Oxygen uptake rate for substrate metabolism of activated sludge decreased largely according to treatment performance in the process with ultrafiltration system. One possible reason for this phenomenon is assumed to be inhibitory effects of the accumulated organic compounds.
|
2022-02-10T15:44:57.798Z
|
233,947,021 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5545/SV-JME.2020.6937",
"MAG": "3133760481",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A magnesium alloy was subjected to strengthening treatment by coupling cavitation bubbles with Al2O3 nanoparticles. The samples were strengthened by embedding Al2O3 nanoparticles with the energy generated by cavitation-bubble collapse, following which a strengthening model was established to perform test verification. The result showed that, after experiencing the combined effect for 5 min, nanoparticles appear on the sample surface, observed under the scanning electron microscope (SEM); by applying the X-ray diffractometer (XRD) and X-ray photoelectron spectrometer (XPS), it is found that the Al2O3 content increases, implying that Al2O3 particles have been embedded in the sample surface. The microhardness of the samples improves by 36 %. In terms of the strengthening mechanism under the combined effect, the energy generated due to cavitation-bubble collapse is transferred to the Al2O3 particles to enable them to strike the sample surface. Thus, the samples have a more gentle impact, and the transition zone with pits formed on the sample surface is significantly smoother and more continuous. Moreover, the samples are further strengthened after Al2O3 nanoparticles are embedded within the sample surface, as these nanoparticles present high strength and microhardness. However, with the increasing duration of the strengthening process, the failure characteristics of surface morphologies of the samples gradually develop; after experiencing the combined effect for 10 min, a large area of the surface is damaged. XRD and XPS results indicate that Al2O3 particles induce a decrease in the binding capacity with the surface layer of the samples and thus gradually separate from the samples. Therefore, the properties of the samples are adversely affected.
|
2022-06-18T22:08:09.058Z
|
10,755,259 |
{
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"ArXiv": null,
"DOI": "10.1258/jrsm.2009.s19006",
"MAG": "2101228128",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://journals.sagepub.com/doi/pdf/10.1258/jrsm.2009.s19006"
}
|
Respiratory exacerbations of cystic fibrosis (CF) lung disease have been associated with increased mortality, hospitalization, antibiotic administration, health costs and diminished quality of life. Preventive strategies such as vaccination against common respiratory pathogens have been developed to reduce the frequency of pulmonary exacerbations.1
Children with CF are vaccinated as per the normal childhood vaccination schedule. They are equally at risk from the common childhood diseases but are particularly susceptible to respiratory complications. Young children with CF may miss out on the normal immunizations schedule through illness and general practitioners need to be aware that cough is not a reason to withhold or delay vaccination. Adults may be more susceptible to infections despite being vaccinated in infancy as immunity reduces over time. The extent of damage caused by vaccine preventable diseases in CF is not known.2 The potential benefit of supplemental vaccination strategies is discussed below.
|
2022-07-30T10:19:10.993Z
|
32,865,631 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1097/00132586-196310000-00002",
"MAG": "2066139241",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract 1. 1. EEG's were taken in the operating room on surgical patients who were lightly anesthetized with 4 per cent ether or 80 per cent N 2 O (20% O 2 ) and were passively hyperventilated to an average PCO 2 of 14 mm Hg and with an average pH of 7.61. 2. 2. No prominent slow activity was noted, although very low PCO 2 values were maintained up to 3–4 h. 3. 3. The relationship of these findings to other data on hyperventilation is discussed.
|
2022-08-27T20:30:12.336Z
|
1,899,197 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4250/jcu.2015.23.1.40",
"MAG": "2092459907",
"PubMedCentral": "4398784"
},
"license": "CCBYNC",
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc4398784?pdf=render"
}
|
A 31-year-old male who had been treated for Churg-Strauss syndrome (CSS) presented with sudden onset of dysarthria. Brain magnetic resonance imaging (MRI) showed acute multifocal bilateral cerebral infarctions suggesting embolic causes. Cardiac MRI showed dilated cardiomyopathy with severe biventricular dysfunction with intracardiac thrombi, and multiple high signal intensity spots in myocardium of the left ventricle with multifocal delayed enhancement suggesting multifocal myocarditis due to small vessel vasculitis associated with CSS. After anticoagulation therapy, treatments for heart failure, and immunosuppressive therapy including parenteral steroids and cyclophosphamide to control CSS, the symptoms and signs of heart failure and cardiac function of the patient were improved. Considering the pathophysiologic mechanism of cardiac involvement in CSS, immunosuppressive therapy to control the disease activity of CSS should be taken into account, besides usual management for heart failure.
|
2022-09-04T03:33:33.865Z
|
24,132,442 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1103/PHYSREVE.87.052103",
"MAG": "2323099818",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this paper, we study experimentally the configurations of a plastic wire injected into a cubic cavity containing periodic obstacles placed along a fixed direction. The wire moves in a wormlike manner within the cavity until it becomes jammed in a crumpled state. The maximum packing fraction of the wire depends on the topology of the cavity, which in turn depends on the number of obstacles. The experimental results exhibit scaling laws and display similarities as well as differences with a recently reported two-dimensional version of this complex packing problem. We discuss in detail several aspects of this problem that seem as intricate as the problem of a self-avoiding random walk. Analogies between the experiment reported and some statistical aspects of the bond-percolation problem, as well as of the interacting electron gas at finite temperature, and other physical issues are also discussed.
|
2022-09-07T12:46:15.762Z
|
72,009,655 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3821/1913701X2008141S19TSOPPI20CO2",
"MAG": "2038776508",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
interpret the headlines and apply the findings of studies regarding the safety of proton pump inhibitors (PPIs). Some authors describe PPIs as completely benign, while other studies report serious complications. By interfering with H/K-ATPase in gastric parietal cells, PPIs maintain a relatively high intragastric pH, beneficial for patients with gastroesophageal reflux disease (GERD). Theoretically, however, changes in intragastric pH could lead to alterations with normal oropharyngeal and gastrointestinal flora, predisposing individuals to infection and decreased absorption of pH-dependent medications, such as calcium. Maintenance of high intragastric pH could therefore be associated with Clostridium difficile (C. difficile) infection, community-acquired pneumonia (CAP) and fractures. Unfortunately, these associations are based on observational studies, making it difficult for practitioners to interpret their implications. This review attempts to distinguish fact from fiction regarding potential associations between adverse effects and PPIs, and provides advice on applying this information in practice.
|
2022-09-11T14:55:16.815Z
|
13,291,619 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.1002/cbin.10728",
"MAG": "2569816277",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Ghrelin is abundantly produced in the stomach. Here, we found that glutamate decreased ghrelin expression and release in ghrelin‐producing cells, and decreased levels of food intake and plasma acyl‐ghrelin in mice. Treatment with siRNA of G protein‐coupled receptor, family C, group 5, member B (GPRC5B) in ghrelin‐producing cell lines completely blocked the effect of glutamate‐induced ghrelin suppression. In addition, glutamate inhibited ghrelin release via the extracellular signal‐regulated kinase (ERK) activity pathway, and stimulated CREB2 mRNA expression in ghrelin‐producing cell lines. These results suggest that glutamate inhibits ghrelin release via ERK‐CREB2 pathway. These results suggest that the GPRC5B‐ERK‐CREB2 pathway is involved in the inhibition of ghrelin expression and secretion in ghrelin cells.
|
2022-12-09T04:27:21.282Z
|
143,994,191 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/0020702014525903",
"MAG": "1994360613",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://uwspace.uwaterloo.ca/bitstream/10012/14185/4/Dunton%20Kitchen%20IJ%20Open%20Access.pdf"
}
|
Even though they claim to recognize that the boundaries between domestic and international security have eroded, scholars of Canadian paradiplomacy have tended to ignore the security-oriented paradiplomatic activities undertaken by sub-national actors in Canada. However, policing paradiplomacy is, in our view, a perfect case for understanding how paradiplomacy in security can change the relationship between the state and its citizens. Through an examination of the paradiplomatic activities of the Royal Canadian Mounted Police, the Sûreté du Québec, and the Vancouver Police, we show how the role of the informal, the danger of mission creep, and the shaping of foreign policy from the margins work to shift how we think about where foreign policy happens.
|
2022-12-16T07:19:23.080Z
|
54,611,104 |
{
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"ArXiv": null,
"DOI": "10.1017/jfm.2012.606",
"MAG": "2137186602",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Abstract When a pair of tandem cylinders is immersed in a flow the downstream cylinder can be excited into wake-induced vibrations (WIV) due to the interaction with vortices coming from the upstream cylinder. Assi, Bearman & Meneghini (J. Fluid Mech., vol. 661, 2010, pp. 365–401) concluded that the WIV excitation mechanism has its origin in the unsteady vortex–structure interaction encountered by the cylinder as it oscillates across the wake. In the present paper we investigate how the cylinder responds to that excitation, characterising the amplitude and frequency of response and its dependency on other parameters of the system. We introduce the concept of wake stiffness, a fluid dynamic effect that can be associated, to a first approximation, with a linear spring with stiffness proportional to $\mathit{Re}$ and to the steady lift force occurring for staggered cylinders. By a series of experiments with a cylinder mounted on a base without springs we verify that such wake stiffness is not only strong enough to sustain oscillatory motion, but can also dominate over the structural stiffness of the system. We conclude that while unsteady vortex–structure interactions provide the energy input to sustain the vibrations, it is the wake stiffness phenomenon that defines the character of the WIV response.
|
2022-12-21T18:13:02.613Z
|
22,725,010 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.1093/AJHP/45.1.116",
"MAG": "2408923269",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The potential effects of using the Baker drug counter or the Systamodule pharmacy fixture, or both, on the efficiency of the current outpatient pharmacy system at the National Institutes of Health were evaluated by computer simulation. It was hypothesized that the use of these two devices would reduce (1) the prescription-filling time (RxFT) and (2) the distance traveled (DT) by pharmacists in filling individual prescriptions. The sample used was 20% of two weeks' prescriptions, randomly selected. All theoretical estimations of RxFT were done by a computer program; DT was calculated based on measurements from the architect's schematic drawings. The effect of the application of the Baker drug counter alone, the Systamodule pharmacy fixture alone, and the Baker drug counter in combination with the Systamodule pharmacy fixture was to reduce the prescription-filling time by 0.123, 0.159, and 0.280 minutes per prescription, respectively. The average DT per prescription, 102 feet, was identical in the current NIH pharmacy and with use of the Baker counter. It was reduced by 86.3% (to 14 feet) with use of the Systamodule feature, both alone and in combination with the Baker counter. The use of the Baker drug counter and the Systamodule together promises improved efficiency of the prescription dispensing operation.
|
2022-12-27T20:04:35.403Z
|
208,812,059 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/003754977602700607",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This report, however, may be one of the most biased on record. We didn’t plan it that way, but so much material was developed and discussed that I couldn’t possibly cover all of it. So I selected that which most interested me, and--in my opinion--would most interest readers of this Newsletter. In some cases, naturally, my selections were made to strengthen, through the use of statements by others, points that I have tried to make in these pages in the past. However, while there may be bias, there is no prejudice.
|
2022-01-27T03:45:26.616Z
|
56,065,613 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.22323/1.236.0644",
"MAG": "2790979401",
"PubMedCentral": null
},
"license": "CCBYNCSA",
"status": "HYBRID",
"url": "https://pos.sissa.it/236/644/pdf"
}
|
Yoshinori Sasai∗,a Tetsuya Kawabata,a Masahiro Ikeno,b Tomohisa Uchida,b Manobu Tanaka,b Yutaka Matsubara,a Yoshitaka Itow,a Takashi Sako,a Diego Lopez,a Rikiya Hikimochi,a Kazuoki Munakata,c Chihiro Kato,c Masayoshi Kozai,c Takaaki Nakajima,c Yoshiaki Nakamura,c Shoichi Shibata,d Akitoshi Oshima,d Hisanori Takamaru,d Hiroshi Kojima,e Harufumi Tsuchiya, f Kyoko Watanabe,g Tatsumi Koi,h J.F.Valdés-Galicia,i Ernesto Ortiz,i Octavio Musalem,i Alejandro Hurtado,i Rocio Garcia,i Marcos Anzorena,i Roberto Taylor,i Marco Barrantes,i and L.X.González, j
|
2022-02-11T19:35:47.353Z
|
245,635,784 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3389/fcell.2021.787118",
"MAG": null,
"PubMedCentral": "8762234"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.frontiersin.org/articles/10.3389/fcell.2021.787118/pdf"
}
|
Bone marrow mesenchymal stromal cells (BMSCs), identified as pericytes comprising the hematopoietic niche, are a group of heterogeneous cells composed of multipotent stem cells, including osteochondral and adipocyte progenitors. Nevertheless, the identification and classification are still controversial, which limits their application. In recent years, by lineage tracing and single-cell sequencing, several new subgroups of BMSCs and their roles in normal physiological and pathological conditions have been clarified. Key regulators and mechanisms controlling the fate of BMSCs are being revealed. Cross-talk among subgroups of bone marrow mesenchymal cells has been demonstrated. In this review, we focus on recent advances in the identification and classification of BMSCs, which provides important implications for clinical applications.
|
2022-11-20T06:12:00.843Z
|
238,638,989 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1101/2021.10.07.463564",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GREEN",
"url": "https://www.biorxiv.org/content/biorxiv/early/2021/10/08/2021.10.07.463564.full.pdf"
}
|
Background We developed the Stem Cell Educator therapy among multiple clinical trials based on the immune modulations of multipotent cord blood-derived stem cells (CB-SC) on different compartments of immune cells such as T cells and monocytes/macrophages in diabetes and other autoimmune diseases. However, the effects of CB-SC on the B cells remained unclear. To better understand the molecular mechanisms underlying the immune education of CB-SC, we explored the modulations of CB-SC on human B cells. Methods CB-SC were isolated from human cord blood units and confirmed by flow cytometry with different markers for their purity. B cells were purified by using anti-CD19 immunomagnetic beads from human peripheral blood mononuclear cells (PBMC). Next, the activated B cells were treated in the presence or absence of coculture with CB-SC for 7 days before undergoing flow cytometry analysis of phenotypic change with different markers. RT-PCR was utilized to evaluate the levels of galectin expressions with or without treatment of activated B cells in order to find the key galectin contributing to the B-cell modulation. Results Flow cytometry demonstrated that the proliferation of activated B cells was markedly suppressed in the presence of CB-SC, leading to the down-regulation of immunoglobulin productions from the activated B cells. Phenotypic analysis revealed that treatment with CB-SC increased the percentage of IgD+CD27- naïve B cells, but decreased the percentage of IgD-CD27+ switched B cells. Transwell assay showed that the immune suppression of CB-SC on B cells was dependent on the manner of cell-cell contact via Gal-9 molecule, as confirmed by the blocking experiment with the anti-Gal-9 monoclonal antibody. Mechanistic studies demonstrated that both calcium levels of cytoplasm and mitochondria were down-regulated after the treatment with CB-SC, causing the decline of mitochondrial membrane potential in the activated B cells. Western blot exhibited that the levels of phosphorylated Akt and Erk1/2 signaling proteins in the activated B cells were also markedly reduced in the presence of CB-SC. Conclusions CB-SC displayed multiple immune modulations on B cells through the Gal-9-mediated cell-cell contact mechanism and calcium flux/Akt/Erk1/2 signaling pathways. The data advances current understanding about the molecular mechanisms underlying the Stem Cell Educator therapy to treat autoimmune diseases in clinics.
|
2022-12-03T04:51:35.205Z
|
221,880,586 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2147/CMAR.S275038",
"MAG": "3085501322",
"PubMedCentral": "7502398"
},
"license": null,
"status": null,
"url": null
}
|
Background Cervical cancer is one of the profound threats to women’s lives and the fourth most common cancer among women. Ethiopia launched the human papilloma vaccination for the first time, with the support of the Global Alliance for Vaccine and Immunization (GAVI) in 2018. Therefore, the aim of this study was to assess the acceptability of the human papillomavirus vaccine and associated factors among parents of daughters in Gondar town, Northwest Ethiopia. Methods A community-based cross-sectional study with a total sample of 946 study participants was conducted in Gondar town from April to May 2019. The study participants were selected using a multistage sampling technique from parents having a daughter of 9−17 years age. Data were collected using an interviewer-administered questionnaire. The data were entered into EpiData version 4.2 and exported to STATA version 14 for analysis. Variables having a p-value of <0.2 and <0.05 in the bivariable and multivariable logistic regression were considered as a statistically significant factor for the acceptance of HPV vaccination. Results A total of 899 study participants with a response rate of 95% were included in the study. Among participants in this study, 81.3% with 95% CI (78.6, 83.7) accepted to vaccinate their daughters for HPV vaccination. The acceptance to vaccinate daughters for HPV vaccination was affected by being from the richest household [AOR= 3.44, 95% CI = (1.97, 6.01)], good knowledge about cervical cancer [AOR=5.49, 95% CI= (2.62, 11.52)], and positive attitude towards HPV vaccination [AOR=21.53, 95% CI= (11.60, 39.96)]. Conclusion The study revealed that the acceptance to human papillomavirus vaccination is high and was significantly associated with the level of knowledge about cervical cancer, the attitude towards HPV vaccination, and the wealth status of the households. Therefore, community education on cervical cancer and its prevention is crucial to increase awareness and acceptance as well.
|
2022-12-29T18:09:14.833Z
|
222,834,475 |
{
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"ArXiv": null,
"DOI": "10.1001/jamanetworkopen.2020.20977",
"MAG": "3093022219",
"PubMedCentral": "7563067"
},
"license": "CCBYNCND",
"status": "GOLD",
"url": "https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2771735/leas_2020_oi_200721_1602001068.3538.pdf"
}
|
This case series assesses whether individuals are using cannabidiol (CBD) to treat diagnosable conditions with proven therapies.
|
2022-12-30T18:01:11.545Z
|
36,509,259 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4244/EIJV12I1A17",
"MAG": "2367337741",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
AIMS
Interventional closure of post-myocardial infarction ventricular septal defects (VSD) is an alternative treatment option to surgical repair. However, only limited evidence exists concerning the interventional closure of a VSD. This review seeks to establish an overview of the existing literature and to carry out a systematic analysis of the success rate and clinical outcome of this procedure.
METHODS AND RESULTS
We conducted a comprehensive systematic literature search to evaluate the existing evidence of percutaneous device closure of post-infarction VSD. Patient series with fewer than five reported cases were excluded. In total, 13 series were identified, with an overall inclusion of 273 patients. Mean patient age was 70 years. Cardiogenic shock was present in 48% of cases at the time of intervention. Device closure within the first 14 days (acute phase) after VSD detection was performed in 42% of cases. Technical success rate was high (>75%). Successful device implantation rate was 89%. Overall in-hospital/30-day mortality was 32%. Major complications included device embolisation, ventricular perfora-tion and arrhythmias.
CONCLUSIONS
Percutaneous device closure of post-myocardial infarction VSD is a valuable alternative to surgical repair, with the advantage of immediate shunt reduction to prevent haemodynamic deterioration. A high rate of technically successful percutaneous procedures can be achieved; however, the mortality rate remains high, especially in cardiogenic shock patients.
|
2022-12-30T15:51:43.231Z
|
217,542,746 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.17163/uni.n23.2015.08",
"MAG": "2273049644",
"PubMedCentral": null
},
"license": "CCBYNCSA",
"status": "GOLD",
"url": "https://revistas.ups.edu.ec/index.php/universitas/article/view/23.2015.08/648"
}
|
This study highlights the importance of inferences generated by religious poetry texts containing important moral and human subjectivity and cultural values in our society, there are currently lacking in the transmission of these values in all social institutions in Latin America, especially in the universities of the city of Guayaquil where compliance with the contents of the curriculum predominate. The study used the method of content analysis, getting to know the connection between poets and young readers, which generates significant for the life of university students inferences, even surpassing deeply to the music of reggaeton. Inferences produced by the young people surveyed are related to aspects related to the humanistic part of the subject especially to respect the ecological, sense of love in our relationships; as well as the integration between pain and love to overcome the trials of life, and finally achieved the connection between our cognitions somewhat subjective divine. We can conclude that the interaction between youth and religious poetry text provides useful knowledge to guide their lives.
|
2022-07-19T23:08:15.471Z
|
219,454,596 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/TMAG.2020.2995514",
"MAG": "3028338461",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Computational architectures that rely on an array of dipole-coupled nanomagnetic elements require an energy-efficient method of programming individual elements within the array. As a low-energy, selective method of controlling magnetization, spin–orbit torque (SOT) represents a promising solution. Here, a finite-difference micromagnetic model is used to characterize the dipole coupling between adjacent CoFeB nanodisks and to determine the critical SOT current required to switch these disks. Additionally, a phase plot showing disk dimensions at which both vortex and single-domain in-plane magnetic states are stable is produced. A dipole-coupled array’s response to dynamic application of SOT current is also simulated. The results show that the rate of applying SOT current to one element in the array strongly influences the stable states of adjacent elements and that the SOT current amplitude required for this influence is an order of magnitude lower than the previously determined critical switching current. This indicates that SOT current dynamics play a significant role in the behavior of a dipole-coupled array. Finally, an architecture to achieve programmability in nanomagnetic computational platforms with SOT is presented.
|
2022-09-23T12:09:51.515Z
|
52,019,769 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/ijd.14183",
"MAG": "2886174846",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
doi: 10.1111/ijd.14224 References 1 Mapelli E, Gualandri L, Cerri A, et al. Comma hairs in tinea capitis: a useful dermatoscopic sign for diagnosis of tinea capitis. Pediatr Dermatol 2012; 29: 223–224. 2 Slowinska M, Rudnicka L, Schwartz RA, et al. Comma hairs: a dermatoscopic marker for tinea capitis: a rapid diagnostic method. J Am Acad Dermatol 2008; 59: S77–S79. 3 Hughes R, Chiaverini C, Bahadoran P, et al. Corkscrew hair: a new dermoscopic sign for diagnosis of tinea capitis in black children. Arch Dermatol 2011; 147: 355–356. 4 Lin Y-T, Li Y-C. The dermoscopic comma, zigzag, and bar code-like hairs: markers of fungal infection of the hair follicles. Dermatol Sinica 2014; 32: 160–163. 5 Wang H-H, Lin Y-T. Bar code–like hair: dermoscopic marker of tinea capitis and tinea of the eyebrow. J Am Acad Dermatol 2015; 72: S41–S42. 6 Lacarrubba F, Verz ı AE, Micali G. Newly described features resulting from high-magnification dermoscopy of tinea capitis. JAMA Dermatol 2015; 151: 308–310. 7 Bourezane Y. Analysis of trichoscopic signs observed in 24 patients presenting tinea capitis: hypotheses based on physiopathology and proposed new classification. Ann Dermatol Venereol 2017; 144: 490–496. 8 Lekkas D, Ioannides D, Apalla Z, et al. Dermoscopy for discriminating between Trichophyton and Microsporum infections in tinea capitis. J Eur Acad Dermatol Venereol 2018; 32: e234–e235. 9 Campos S, Brasileiro A, Galhardas C, et al. Follow-up of tinea capitis with trichoscopy: a prospective clinical study. J Eur Acad Dermatol Venereol 2017; 31: e478–e480. 10 Richarz NA, Barboza L, Monson ıs M, et al. Trichoscopy helps to predict the time point of clinical cure of tinea capitis. Australas J Dermatol 2018. Available from: https://onlinelibrary.wiley.com/d oi/abs/10.1111/ajd.12830 [Epub ahead of print]
|
2022-12-11T12:50:53.139Z
|
101,778,643 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1039/C6PY00066E",
"MAG": "2279058697",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We demonstrate that useful bio-based amphiphilic polymers can be produced enzymatically at a mild temperature, in a solvent-free system and using renewably sourced monomers, by exploiting the unique properties of supercritical CO2 (scCO2). We present the use of a novel near-ambient temperature approach to prepare renewable amphiphilic ABA copolymers in scCO2. Bio-based commercially available monomers have been polymerised to prepare chains with targeted molecular weight. The amphiphilic materials were prepared by end-capping the synthesised polymers with methoxy poly(ethylene glycol) (MPEG) chains in a one-pot high pressure reaction utilising Candida Antarctica Lipase B (CaLB) as a catalyst at a temperature as low as 35 °C. The block copolymers are characterised by 1H-NMR, GPC and DSC in order to carefully assess their structural and thermal properties. These polymers form self-assembled aggregates in aqueous environment and these nanostructures are studied through DLS, TEM and UV-Vis. Highly hydrophobic Coumarin-6 was used as a model to prove dispersion in water of lipophilic molecules. Maximum bubble pressure tests demonstrate the reduction in surface tension of these polymers and comparisons are made directly to commercial polymeric non-ionic surfactants.
|
2022-12-30T00:22:25.304Z
|
221,141,806 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1101/2020.08.13.249466",
"MAG": "3049181159",
"PubMedCentral": null
},
"license": "CCBYNCND",
"status": "GREEN",
"url": "https://www.biorxiv.org/content/biorxiv/early/2020/08/14/2020.08.13.249466.full.pdf"
}
|
Ubiquitous constraints derived from the muscle’s structure limit the power capacity of fast contracting muscles. Correspondingly, organisms evolved elastic elements that store energy which, when released, can be used to rapidly accelerate appendages. Such latch-mediated spring actuation (LaMSA) systems comprise of a single elastic element and are used to actuate a single mass. Here we reveal a dual LaMSA system in seahorses, in which two elastic elements actuate two masses: the head as they rapidly swing it towards the prey, and the water mass sucked into the mouth to prevent the prey from escaping. This power-amplified system enhances the speeds of both head rotation and suction flows by x10 compared to similarly-sized fish. Furthermore, the dual system provides temporal coordination between head rotation and suction flows, a novel function for LaMSA. These findings extend the known function, capacity and design of LaMSA systems.
|
2022-02-03T10:06:16.553Z
|
56,000,002 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.11648/j.ijcd.20180101.13",
"MAG": "2810411597",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Emergency Obstetric and Newborn Care (EmONC) is a life-saving approach for mother and newborn experiencing complications during pregnancy, childbirth and or postpartum period. Like other developing countries, Ethiopia has high maternal and neonatal mortality (353/100,000 live births and 28/1000 live births respectively by 2015) where majority of them are due to lack of timely, effective, and accessible EmONC services. Even though Addis Ababa, Harar and Dire Dawa have met the WHO minimum requirements of EmONC service in terms of Availability and Accessibility unlike other regions, the report shows that the quality of care provided was highly compromised and mainly associated with poor providers’ competence. A cross-sectional study design was employed in purposively selected health care facilities in Dire Dawa city to assess providers’ level of knowledge, skills and confidence for provision of quality EmONC. The study used self-administered standardized questionnaire. Information letters, consent forms and questionnaires was handled to potential participants by research assistants. Data was coded, cleaned and entered using Epi Info 7 (7.0.9.34) and analyzed using SPSS version 20 for descriptive and inferential statistics. The finding of this study reveals that, out of 52 maternal and newborn health care providers filling questionnaires, majority (67.35%) of providers were untrained, where large numbers (38.5%) were reported from Health centers. Forty-five (86.04%) were reported of having sufficient knowledge of EmONC; while 31 (59.4%) and 46 (88.45%) reported of having adequate skills and confidence of performing major EmONC procedures, respectively. In conclusion, Even though there is a significant variation based on clinicians’ place of work and year of work experience, providers’ knowledge, skills and confidence were adequate. But, gaps in trained and specialized MNCPs were highly contributing to lack of improvements in quality of EmONC in Dire Dawa. Thus, the findings bear considerable implications for policy and local priorities.
|
2022-02-11T19:37:27.294Z
|
169,759,922 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.21953/lse.t73913kmqqzm",
"MAG": "2796830587",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The taxation-accountability theory broadly states that if governments are dependent on taxation, they will become less corrupt and more accountable to citizens. The need to raise tax revenue is said to spark incentives that lead to mutually beneficial bargaining between government and citizens. Citizens agree to make tax payments in return for more accountable governance and increased influence in government decision-making. Several scholars have shown empirical evidence in support of this taxationaccountability theory at the national level, yet few have studied it at the local government level.
This paper explores this theory in the context of Mexican municipal governments using a mixed methods research approach. It first surveys the relationship between taxation and accountability using econometric analysis and then employs a comparative case study of six urban municipalities that are under considerable pressure to raise their tax revenue. The latter is based on several months of field research conducted in the states of Guerrero, Tabasco, Baja California Sur, Aguascalientes, Yucatan and Coahuila. It reveals the processes that evolve from revenue pressure, whether they lead to tax bargaining, and the extent to which greater accountability can be expected as a result.
The findings provide some evidence of tax bargaining and positive correlations between the importance of taxation in a government’s budget and accountability. However, the causal link to greater accountability is not straightforward and is greatly hindered by the institutional framework surrounding local government. While implicit agreements between government and citizens showed that equilibrium between taxation and
accountability was consistently maintained, restrictions on local power and other institutional factors stood in the way of increased local taxation sparking greater local accountability. These factors may be remedied by reform.
|
2022-03-11T07:16:40.892Z
|
122,043,924 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/WVM.1989.47113",
"MAG": "2155575944",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The authors consider the problem of combining the use of points and lines in a sequence of images to recover the 3D structure and motion. They determine the configurations that yield a resolvable system of equations, treating the cases of two and three views in more detail. For the case of two views, they show that lines are not needed, as they do not contribute to the obtaining of a resolvable system of equations. For the case of three views, the authors list the few interesting resolvable configurations. They also indicate how to obtain rigidity-based equations using structural invariance. Finally, they show why combining points and lines can be particularly useful when occultation occurs.<<ETX>>
|
2022-10-03T14:55:26.576Z
|
6,167,185 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1359/jbmr.040116",
"MAG": "2071508609",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1359/jbmr.040116"
}
|
The efficacy of oral clodronate 800 mg daily to reduce vertebral fractures was studied in 593 women with postmenopausal or secondary osteoporosis. The incidence of vertebral fractures was significantly reduced by 46%. The effect was not modified by the underlying cause of osteoporosis or other baseline factors including bone mineral density, QUS, weight, and smoking.
|
2022-12-04T18:04:46.457Z
|
21,448,341 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/J.1574-6968.2002.TB11388.X",
"MAG": "2000948903",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A region of the Leptospira interrogans serovar pomona genome encoding DNA replication genes was characterized. This region, designated the ppa-ntrC locus, includes 19 open reading frames and a new insertion sequence, IS1502. Although this locus resembles replication origins from many eubacteria, it lacks several genes common to homologous loci. Some replication-related genes were previously located near rrf, and may have been moved to that location by homologous recombination between short sequence elements common to both loci. Further analysis showed that the ppa-ntrC region has undergone substantial change during spirochete evolution. Transcription analysis using RT-PCR revealed uniquely organized polycistronic mRNAs in the ppa-ntrC locus. The dnaN and recF intergenic region of serovar pomona was different from the homologous sites of 41 L. interrogans serovars by the presence of IS1502. The distribution of IS1502 throughout pathogenic Leptospira species varies. This result suggests that IS1502 may have been recently introduced into Leptospira.
|
2022-12-12T03:09:06.980Z
|
196,494,854 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1200/JCO.2015.33.15_SUPPL.E19500",
"MAG": "2763804460",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
e19500 Background: We recently reported that the infused autograft lymphocyte to monocyte ratio (A-LMR) is a prognostic factor for survival in B-cell lymphomas post-autologous peripheral hematopoietic stem cell transplantation (APHSCT). Thus, we set out to investigate if the A-LMR is also a prognostic factor for survival post-APHSCT in T-cell lymphomas. Methods: From 1998 to 2014, 109 T-cell lymphoma patients that underwent APHSCT were studied. Receiver operating characteristic and area under the curve identified an A-LMR ≥ 1 as the best cut-off value and validated by the k-fold cross-validation. Results: . Multivariate analysis showed A-LMR to be an independent prognostic factor for overall survival (OS) and progression-free survival (PFS). Patients with an A-LMR ≥ 1.0 experienced a superior OS and PFS versus patients with an A-LMR < 1.0 [median OS was not reached vs 17.9 months, 5-year OS rates of 87% (95 CI, 75%-94%) vs 26% (95 CI, 13%-42 %), p < 0.0001, respectively; median PFS was not reached vs 11.9...
|
2022-02-08T07:07:12.498Z
|
237,638,159 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3389/fmed.2021.699644",
"MAG": null,
"PubMedCentral": "8502934"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.frontiersin.org/articles/10.3389/fmed.2021.699644/pdf"
}
|
Background: Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is a severe complication associated with a high mortality. However, evidence and guidance on management is sparse. The aim of this international survey was to assess differences in prevention, diagnostic and treatment strategies for AE-IPF in specialised and non-specialised ILD centres worldwide. Material and Methods: Pulmonologists working in specialised and non-specialised ILD centres were invited to participate in a survey designed by an international expert panel. Responses were evaluated in respect to the physicians' institutions. Results: Three hundred and two (65%) of the respondents worked in a specialised ILD centre, 134 (29%) in a non-specialised pulmonology centre. Similarities were frequent with regards to diagnostic methods including radiology and screening for infection, treatment with corticosteroids, use of high-flow oxygen and non-invasive ventilation in critical ill patients and palliative strategies. However, differences were significant in terms of the use of KL-6 and pathogen testing in urine, treatments with cyclosporine and recombinant thrombomodulin, extracorporeal membrane oxygenation in critical ill patients as well as antacid medication and anaesthesia measures as preventive methods. Conclusion: Despite the absence of recommendations, approaches to the prevention, diagnosis and treatment of AE-IPF are comparable in specialised and non-specialised ILD centres, yet certain differences in the managements of AE-IPF exist. Clinical trials and guidelines are needed to improve patient care and prognosis in AE-IPF.
|
2022-12-12T14:57:51.225Z
|
1,171,102 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1097/MD.0000000000005903",
"MAG": "2599036694",
"PubMedCentral": "5312986"
},
"license": null,
"status": null,
"url": null
}
|
Background: Lung cancer is responsible of 12.4% and 17.6% of all newly diagnosed cancer cases and mortality due to cancer, respectively, and 5-year survival rate despite all improved treatment options is 15%. This survival rate reaches 66% in the Stage 1 and surgically treated patients. Early diagnosis which could not be definitely and commonly achieved yet is extremely critical in obtaining high survival rate in this disease. For this reason; proteomic differences were evaluated using matrix assisted laser desorption ionization (MALDI) mass spectrometry in the subgroups of lung adenocarcinoma and squamous cell carcinoma. Methods: Fresh tissue samples of 36 malignant cases involving 83.3% (n = 30) men and 16.7% (n = 6) women patients were distributed into 2 groups as early and end stage lung cancer and each group were composed of subgroups including 18 squamous cell carcinoma (9 early stage cases, 9 end stage cases) and 18 adenocarcinoma cases (9 early stage cases, 9 end stage cases). The fresh tissues obtained from the tumoral and matched normal sites after surgical intervention. The differences in protein expression levels were determined by comparing proteomic changes in each patient. Results: In the subgroups of advanced stage adenocarcinoma; tumoral tissue revealed differences in expression of 2 proteins compared with normal parenchymal tissue. Of those; difference in protein expression in heat shock protein 60 (HSP60) was found statistically significant (P = 0.0001). Subgroups of early and advanced stage squamos cell carcinoma have differed in certain 20 protein expression of normal tissue and diseased squamos cell carcinoma. Of those, increased protein expression level of only annexin-2 protein was found statistically significant (P = 0.002). No significant difference was detected in early and advanced stage protein expressions of the tumoral tissues in the subgroups of adenocarcinoma and squamous cell carcinoma. Conclusions: We conclude that with respect to early diagnosis of lung cancer that HSP60 and annexin-2 proteins are the important biomarkers in the subgroups of adenocarcinoma and squamous cell carcinoma. We also consider that these 2 proteins are molecules which may provide critical contribution in evaluation of prognosis, metastatic potential, response to treatment, and in establishment of differential diagnosis between adenocarcinoma and squamous cell carcinoma.
|
2022-12-21T09:18:36.133Z
|
132,361,749 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1515/9783110266306.199",
"MAG": "2490079857",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://www.degruyter.com/downloadpdf/book/9783110266306/10.1515/9783110266306.199.pdf"
}
|
In the last forty years, continuing rescue excavations in the Lower Traisen valley (Unteres Traisental) in Lower Austria have identified about 180 burials dating to the final Neolithic (2600–2200 BC). They belong to the Corded Ware culture and Late Bell Beaker culture. Enamel from permanent teeth of a total of 49 individuals originating from Subsites I, II and III of the Franzhausen (FH) excavation area were analysed with respect to their strontium isotopic composition. The aim was to identify locals and nonlocals and to contribute to questions of mobility and migration. We applied a validated routine procedure for Sr isotope ratio measurements using solutionbased multiple collector inductively coupled plasma mass spectrometry (MC-ICP-MS). In addition, recent soil samples from the Franzhausen area were extracted by ammonium nitrate solutions in order to delimit the local isotope signal of bioavailable Sr in the region. 87Sr/86Sr ratios in the enamel revealed that about 88% of the investigated individuals are autochthonous. These data were subjected to a further detailed evaluation with respect to the individuals’ age at death and sex, as well as to a possible spatial differentiation (FH I, II and III) and cultural affiliation. Sr isotope ratio data show no pattern regarding age at death. Higher mobility was found for male individuals compared to that for females. Results evaluated according to chronological and spatial subgroups imply differences in mobility. Distinct groups of representatives of the Corded Ware culture in the subsites were identified as nonlocals, whereas all of the investigated individuals assigned to the Late Bell Beaker culture were locals.
|
2022-12-21T10:26:00.191Z
|
170,149,636 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.7202/1064398AR",
"MAG": "1557056770",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Resume : Le probleme philosophique est de savoir comment definir cette notion de Desordre : est-ce que, par Desordre, il faut entendre, de facon negative, la fin de l'ordre naturel suppose universel, (...)
|
2022-01-27T19:52:19.140Z
|
216,966,103 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5752/P.2175-5841.2017V15N48P1525-1543",
"MAG": "2782050573",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The present essay aims at reading the eighth chapter of Finnegans Wake (2004; 2009), known as “Anna Livia Plurabelle”, by the Irish writer James Joyce. We intend to collate the notions of “letter” and “resurrection”, not in a thematic analysis, but in a reading that highlights the text’s immanence, the textual surface. In order to achieve our goal we make use of theoretical apparatus from literary theory (AMARANTE, 2009; BLANCHOT, 2011, 2005; BRANCO, 2011, 2000; LAERE, 1969; MANDIL, 2003; SCHULER, 2004), from theology (AQUINO, 2002; BALTHASAR, 1971), from psychoanalysis (LACAN, 2007, 2009, 2008) and from philosophy (NANCY, 2001, 2006). Thereby, we seek to understand how the readability of James Joyce’s text invite us to a reading that focuses on the materiality of the “letter”, such as it is written: in a discontinuous movement, by which the text is written as a body in continuity – the text is recognizable as made out of letters – disrupting – the meaning is not built for plot decoding and interpretation– which evanesces itself; we named this movement “resurrection”.
|
2022-01-27T05:52:24.291Z
|
54,534,559 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.14776/KJPID.2014.21.2.144",
"MAG": "2032268186",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Acute otitis media (AOM) is one of the most common childhood infectious diseases. Despite antibiotic treatment for AOM, AOM and its complication still continue to develop. Acute mastoiditis is a serious complication of AOM and epidural abscess constitutes the commonest of all intracranial complication of AOM. Neurological complication of acute mastoiditis are rare but can be life threatening. Their presentation may be masked by the use of antibiotics. We report the rare case of acute otitis media progressing to acute mastoiditis, epidural abscess formation and lateral sinus thrombophlebitis caused by Streptococcus pneumoniae in a child. She was admitted with acute otitis media with fever. Despite proper antibiotics, acutemastodititis and epidural abscess were developed, and after surgical drainage and antibiotics therapy she was recovered without sequalae.KeyWords:Epidural abscess, Mastoiditis, Otitis media, Streptococcus pneumoniae
|
2022-01-27T20:56:39.384Z
|
96,699,084 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/10584580490893079",
"MAG": "2097237325",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A single transistor type ferroelectric memory with multiple bit operation was presented. This cell has a metal ferroelectric insulator semiconductor field effect transistor structure. Y2O3 thin film was used as a buffer insulating layer to improve the memory characteristics and SrBi2Ta2O9 was used as a ferroelectric gate material. The multi-level characteristics of four levels with one order of drain current difference were measured according to the writing voltage step of two volt. This multi-level memory cell enables to increase the density of memory in the same space and lower the cost.
|
2022-02-10T14:07:59.986Z
|
62,882,215 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5370/JEET.2008.3.1.014",
"MAG": "2097034743",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The paper presents an intelligent time series model to predict uncertain electricity market price in the deregulated industry environment. Since the price of electricity in a deregulated market is very volatile, it is difficult to estimate an accurate market price using historically observed data. The parameter of an intelligent time series model is obtained based on the simultaneous perturbation stochastic approximation (SPSA). The SPSA is flexible to use in high dimensional systems. Since prediction models have their modeling error, an error compensator is developed as compensation. The SPSA based intelligent model is applied to predict the electricity market price in the Pennsylvania- New Jersey-Maryland (PJM) electricity market.
|
2022-07-29T12:58:08.967Z
|
250,826,213 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1088/0256-307X/22/6/072",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Using observation data of the Tibet air shower array in different periods, a region with the highest excess of 4.4 σ in the multi-TeV was detected from the SNR G40.5-0.5 direction, although statistically insignificant yet. The position of the highest excess is located around the EGRET unidentified source 3EG J1903+0550.
|
2022-07-31T09:08:14.459Z
|
41,034,973 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/VTS.2002.1011149",
"MAG": "2098521527",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The advent of terabit aggregate rate telecommunication devices and multi-gigahertz I/O interfaces is posing new challenges on the semiconductor and ATE industries. Telecom chipmakers are currently using ad hoc techniques to test these kinds of devices due to the lack of a credible commercial solution. This session highlights the challenges of testing multi-gigahertz interfaces and presents promising early solutions.
|
2022-09-07T09:33:07.508Z
|
222,953,716 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2991/dsahmj.k.200917.001",
"MAG": "3089200491",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.atlantis-press.com/article/125944785.pdf"
}
|
1King Abdulaziz Medical City / King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia 2King Abdullah International Medical Research Center / King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia 3Department of Medicine, Aseer Central Hospital, Abha, Saudi Arabia 4Neurology Department, Kasr Al Ainy Hospital, Faculty of Medicine, Cairo University, Cairo, Egypt 5College of Medicine, King Khalid University, Abha, Saudi Arabia
|
2022-07-11T02:29:37.642Z
|
43,338,313 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2169/INTERNALMEDICINE.53.1300",
"MAG": "2041481267",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We herein report the case of a 69-year-old woman with left atrial myxoma detected following treatment with glucocorticoids for an initial diagnosis of polymyalgia rheumatica (PMR). The glucocorticoids markedly improved the patient's symptoms, and the tumor was excised after rapidly tapering the glucocorticoid dose. The PMR-like symptoms did not recur and the inflammatory marker levels returned to normal after surgery. The patient's clinical course indicated that the initial PMR-like symptoms were entirely caused by the left atrial myxoma. This case demonstrates that glucocorticoid treatment for suspected PMR can mask the symptoms of myxoma, leading to a delay in diagnosis.
|
2022-09-13T11:27:48.579Z
|
101,379,493 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1515/hfsg.1975.29.1.25",
"MAG": "2334542677",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Schlüsselwörter (Sachgebiete) Fluor Bor F-B Komplex Termitenwidrigkeit Nasutitermes exitiosus Eucalyptus regnans Copper-Fluorine-Boron Diffusion Wood Preservative. III. Termiticidal Effect of Fluorine, Boron and F-B Complex Summary The termiticidal effectiveness of fluorine from NaF, boron from B(OH)3 and F-B complex (with atomic ratio i.iF:iB) was determined in Eucalyptus regnans against Nasutitermes exitiosus, using a standard jar technique with specimens in contact with moist matrix material. There were indications that fluorine and boron elicit different responses from the termites in terms of eating patterns. On a mol atom basis, an apparent threshold retention value (at 5 % wood eaten) of 100 mol was indicated for both fluorine and boron. However, diffusion losses from the wood were detected and after allowing for these it seems that the actual threshold value could be considerably less. The termiticidal efficacy of the two elements on an atom for atom basis was about F = . In the complexed form at comparable mol-atom concentrations the F and B elements appeared less effective. The tentative explanation offered is that the metabolic processes in the test termites were unable to break up fluorohydroxoborates and this led to lower concentrations of free fluoride, and to a lesser extent of borate. Analysis of the specimens before and after the test showed losses of fluorine and boron. For this reason, where a method allows diffusion of components from specimens to occur, any termiticidal values must be suspect as the actual thresholds could be lower than those reported.
|
2022-11-19T16:15:39.142Z
|
196,263,953 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1590/0080-6234198501900300231",
"MAG": "1566758162",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "http://www.scielo.br/pdf/reeusp/v19n3/0080-6234-reeusp-19-3-231.pdf"
}
|
The basics procedures of nursing care to the premature are presented here. They are: observation of the premature during the first 24 hours of life, hidratation by bottle, feeding by nosogastric tube, care of premature after feeding, tecnnique of bathing the premature in the incubator, care of premature skin to avoid from infection, care of the umbilical stump, care of premature with moniliasis, with respiratory distress, with diarrhea, with vomitus, cleaning and preservation of the incubator, care of the premature who is receving oxigen therapy, control of humidity of the incubator, care of the premature under phototherapy, care with the phototherapy equipment.
|
2022-11-18T00:45:23.152Z
|
117,297,478 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.51257/a-v1-b7190",
"MAG": "2774233357",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
1 Constitution d'un robot industriel 1.1 Structure fonctionnelle 1.2 Structure organique 1.3 Structures mecaniques 1.31 Nombre d'axes 1.32 Nature des axes (axes principaux, axes de poignet) 2 Description des organes constitutifs d'un robot industriel 2.1 Motorisation 2.11 Criteres de performances 2.12 Motorisation hydraulique 2.13 Motorisation electrique 2.14 Tendances d'evolution 2.2 Reducteurs 2.21 Criteres de performances 2.22 Reducteurs utilises en robotique 2.3 Organes de transmission 2.31 Criteres de performances 2.32 Vis a roulement 2.33 Transmission par pignons 2.34 Transmission par bielles 2.35 Transmission par courroies 2.36 Transmission par chaines 2.37 Paliers 2.4 Capteurs 2.41 Criteres de performances 2.42 Capteurs de position utilises en robotique 3 Performances des robots industriels 3.1 Volume de travail 3.2 Charge 3.3 Rapidite 3.4 Facteur de service 3.5 Precision 3.6 Sensibilite a l'environnement 4 Exploitation des robots industriels 4.1 Securite (securite des sites robotises et des robots industriels) 4.2 Maintenabilite 4.3 Maintenance mecanique et electrique 4.4 Fiabilite. Duree de vie 4.5 Disponibilite operationnelle Documentation
|
2022-12-16T17:00:01.880Z
|
19,897,065 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2106/00004623-199711000-00004",
"MAG": "1932541972",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We describe a computer-assisted vector wear technique for the determination of polyethylene wear on digital radiographs. Twenty-five hips that had had a total hip arthroplasty were used to evaluate the repeatability and performance of three radiographic techniques to measure wear of the acetabular polyethylene liner: the manual technique with use of calipers described by Livermore et al., the same technique with use of a digitizing tablet, and our new technique of computer-assisted vector wear analysis. We found our new technique to be at least ten times more repeatable than the technique with use of either calipers or a digitizing tablet. Fourteen of the polyethylene liners were retrieved at autopsy, and the actual measurements of wear of those liners were compared with the measurements that had been obtained with the three radiographic techniques of wear analysis. Computer-assisted vector wear analysis outperformed the manual techniques of Livermore et al. When compared with the data obtained from the specimens retrieved at autopsy, the measurement of wear determined with the computer-assisted technique differed by an average of 0.08 millimeter, whereas the measurements obtained with use of calipers and use of a digitizing tablet differed by 0.26 and 0.25 millimeter, respectively. The performance of computer-assisted vector wear analysis in the clinical setting was evaluated with use of controls with known amounts of wear. These were mounted in pelvic phantoms, and radiographs were made with use of a setup that simulated the clinical setting. Analysis of nine controls with 2.0 millimeters of wear yielded an average measurement of wear (and a standard deviation) of 1.99 ± 0.21 millimeters. CLINICAL RELEVANCE: Computer-assisted vector wear analysis demonstrated superior repeatability and accuracy compared with current techniques of manual analysis. Improved repeatability and accuracy in the determination of polyethylene wear should facilitate the investigation of factors related to the prosthesis and to the patient that affect the rates of wear.
|
2022-12-16T00:01:37.069Z
|
125,071,959 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.24033/BSMF.617",
"MAG": "2265004897",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
© Bulletin de la S. M. F., 1900, tous droits réservés. L’accès aux archives de la revue « Bulletin de la S. M. F. » (http: //smf.emath.fr/Publications/Bulletin/Presentation.html) implique l’accord avec les conditions générales d’utilisation (http://www.numdam.org/ conditions). Toute utilisation commerciale ou impression systématique est constitutive d’une infraction pénale. Toute copie ou impression de ce fichier doit contenir la présente mention de copyright.
|
2022-12-16T00:09:39.488Z
|
240,672,086 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.21203/rs.3.rs-958560/v1",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GREEN",
"url": "https://www.researchsquare.com/article/rs-958560/latest.pdf"
}
|
The purpose: The aim of this study is to determine the burden of DM among patients admitted to tertiary hospitals in Mukalla city at eastern Yemen.Patients and methods: It is a cross sectional study among patients admitted to in three main hospitals in Mukalla city. Results: the prevalence of DM among admitted patients to the three hospitals in Mukalla city is 16.6%. Age specific prevalence rate is higher among adults over 40 years (40.3%) than the younger patients (2.2%). In a logistic regression only, age is a determinate factor to DM. The main symptoms and signs of the hospitalized DM patients are: polyurea (72.6%), polydipsia (70.5%), blurring of vision (57.9%), marked loss of weight (54.7%) Paresthesia (51.2%) and polyphagia (34.7%). The main complications among hospitalized DM patients are difficulty of vision (60.8%), Foot ulcer (53.6%) and loss of libido (49.2%).Conclusion: The prevalence of DM among hospitalized patients is high.
|
2022-06-25T22:56:46.345Z
|
247,299,284 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.15381/lengsoc.v18i2.22320",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://revistasinvestigacion.unmsm.edu.pe/index.php/lenguaysociedad/article/download/22320/17875"
}
|
En este artículo tratamos de reflexionar sobre la recientemente descubierta lógica de adquisición del conocimiento práctico y sus consecuencias para la educación y políticas educativas. Esta lógica se manifiesta en el proceso de socialización, que va concatenando unidades de sentido que son prácticas sociales con reglas implícitas y nunca formuladas, que requieren habilidades que el niño hace suyas mientras va haciéndose de su propio universo de sentido. Ese es el marco de referencia del niño: el sentido común, no el conocimiento del mundo. Porque la única fuente de conocimiento que tiene el niño es su lenguaje y su comunidad. Es este proceso el que evidencia la verdadera lógica del lenguaje, porque así como se adquiere el lenguaje, así es. Y solo reconociendo el lugar dominante que tiene la lógica del conocimiento práctico es que podemos sentar las bases de una educación pertinente e intercultural de todos que pueda evitar los gruesos etnocentrismos y los problemas del rechazo cultural que siempre enfrentan los proyectos educativos que no se sustentan en las culturas pedagógicas de los pueblos.
|
2022-09-02T03:58:53.055Z
|
52,287,778 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1155/2018/5215128",
"MAG": "2889170618",
"PubMedCentral": "6136468"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://doi.org/10.1155/2018/5215128"
}
|
Pancreatic tuberculosis (TB) is an uncommon form of extrapulmonary TB and represents a diagnostic challenge for physicians. Pancreatic TB presents with nonspecific signs and symptoms and may mimic malignancy. However, pancreatic TB rarely occurs in children. Here, we present a case of a 5-year-old girl with pancreatic TB and markedly elevated serum cancer antigen- (CA-) 125 levels, thus raising the suspicion of malignancy, but positivity for Mycobacterium tuberculosis DNA was noted. The patient recovered after being administered standard antitubercular therapy for one year. This case suggests that clinicians should have a heightened suspicion of pancreatic TB when faced with pancreatic lesions despite the fact that increased CA-125 may indicate malignancy. Laparoscopy combined with peritoneal biopsy and polymerase chain reaction (PCR) may provide a new method to confirm the diagnosis.
|
2022-09-08T22:40:23.886Z
|
14,004,843 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1371/journal.pone.0032414",
"MAG": "2015352996",
"PubMedCentral": "3308957"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0032414&type=printable"
}
|
Background The Cochrane Collaboration aims at providing the best available evidence for interventions in health care. We wished to examine to which extent treatments considered relevant by caregivers in type 2 diabetes are covered by Cochrane systematic reviews. Methodology/Principal Findings 130 different interventions in type 2 diabetes were identified based on a review of clinical practice guidelines and expert opinion (Table S1). 459 members of the German Diabetes Society (diabetologists, general practitioners, diabetic nurses, nutritionists, podologists, others) were surveyed via e-mail-list to rank a) the perceived clinical relevance and b) the perceived need for evidence of interventions, based on an internet survey. In the Cochrane Library, there were, at the time of this evaluation, 56 reviews on interventions in diabetes. Generally, coverage of topics by Cochrane reviews reflected the perceived clinical relevance and perceived need for evidence. As an example, highly ranked treatments such as lifestyle changes or oral antidiabetics were well covered, while low rank treatments such as complementary approaches were not covered. Discrepancies occurred with new treatments such as amylin-analogues (low relevance, high need for evidence, review not yet completed) and interventions with immediate and dramatic effects such as treating hypoglycemia (high relevance, low need for evidence, no review). Also, there was a relative scarcity of reviews concerning specific problems, in particular, treatment of late diabetic complications. Conclusions/Significance For most interventions, perceived relevance and perceived need for evidence are reflected by the evidence already available. Prioritizing should aim at improving immediacy and consideration of the treatment of complications.
|
2022-11-25T00:45:21.037Z
|
71,697,601 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1590/S0100-69912001000600008",
"MAG": "1989482233",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
BACKGROUND: Comparative analysis of a retrospective study of the free disease survival of 31 patients with cervical metastasis with unknown primary tumor, and 637 patients with head and neck cancer of the mouth, oropharynx and hypopharynx submitted to neck dissection, in the Head and Neck Service of the Heliopolis Hospital Complex, Sao Paulo, Brazil, between 1977 and 1995. METHOD: Free disease survival curves were determined by the KAPLAN & MEIER method, taking into consideration the N factor of TNM classification (UICC - AJC 1997) for the patients with unknown tumor sites, and the T and N factors for those diagnosed with primary tumor. These curves were compared by the log-rank test. RESULTS: the comparison of free disease survival (FDS) of patients with cancer of the mouth (m), oropharynx (o) and hypopharynx with unknown primary (up) lesion were established through 9 curves, considering values of p, with T and N parameters. CONCLUSIONS: the verifications of differents survival curves did not detect statistical diferences for the Free Disease Survival in 9 planned curves (all values of p more than 0,05), for patients with cervical metastasis with unknown primary tumor, and those with mouth, oropharynx and hypopharynx tumors, submitted to neck dissection.
|
2022-11-25T00:29:59.311Z
|