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146,237,323 |
{
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"DOI": "10.1017/S0144686X00001781",
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|
genetic aspects are presented including the role of hybrid vigour. Finally, the current resurgence of the free radical theory is exposed. The discussions are accompanied by a comparison of images of young, actively-dividing cells (phase 2) as opposed to old cells (phase 3) in culture. However, as with other (excellent) shots of cells, there are no pointers to the specific features under discussion and if the viewer is not familiar with cells then he or she will be bemused. Attempts to overcome ageing changes at the cellular level are presented and include a study of a treatment which permits the fibroblasts in vitro to remain in phase 2, though the magic compound responsible for this is carefully left unstated, as is the relevant information relating to feeding experiments concerned with life-span extension experiments in the fruit fly, Drosophila. This latter is considered in the context of the known effects of dietary restrictions increasing the life-span of mammals. Our attempts to disguise at least the visually apparent effects of ageing and the involvement of cosmetics are discussed briefly and include the above mentioned treatment of senescing cells. Two aspects of the video which are inconsistent with the general presentation concern a long episode starting with the King's Cross underground station fire and the identification of badly-burned individuals by reconstructing the face. The difficulties of deciding the age of the individual when rebuilding the face emphasise the points which were made earlier and add little to the discussion of senescence. In addition, the treatment of sex and elderly people is limited to a consideration of how to overcome male sexual impotence. One minor error concerns the description of a child showing genetic premature ageing as Werner's syndrome rather than HutchinsonGilford syndrome. Altogether, the video is well made and the themes interwoven to make for interesting viewing, though almost a quarter of the time is taken with marginally relevant material.
|
2022-12-19T09:20:52.299Z
|
15,831,936 |
{
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"ArXiv": null,
"DOI": "10.1109/TSP.2007.911493",
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|
We address a lifetime maximization problem for a single-hop wireless sensor system (also known as a Gaussian sensor network) where multiple sensors encode and communicate their measurements of a Gaussian random source to a fusion center (FC). The FC is required to reconstruct the source within a prescribed distortion threshold. The lifetime optimization problem is formulated as a joint power, rate, and timeslot [for time-division multiple access (TDMA)] allocation problem under the constraints of the well-known rate distortion constraints for the Gaussian CEO problem, the capacity constraints of the wireless links, the energy constraints of the sensor nodes and the strict delay constraint within which the encoded sensor data must arrive at the FC. We study the performances of TDMA and an interference limited nonorthogonal multiple access (NOMA) (with single-user decoding)-based protocols and compare them against recently reported simple uncoded amplify and forward schemes under a nonorthogonal multiple access channel with complete phase synchronization. Since computing the exact capacity region for correlated sources in a multiaccess channel is difficult, we simply consider the Gaussian multiaccess capacity constraints pretending that the sensor data are independent (although they are clearly not). We show that the optimal lifetime achieved under these capacity constraints provides an upper bound on the optimal lifetime achieved by the TDMA and NOMA protocols. While the constrained nonlinear optimization problems for the TDMA and the Gaussian multiaccess cases are convex, the NOMA case results in a nonlinear nonconvex difference of convex functions (D.C.) programming problem. We provide a simple successive convex approximation based algorithm for the NOMA case that converges fast to a suboptimal lifetime performance that compares favorably against the upper bound provided by the Gaussian multiaccess case. Extensive numerical studies are presented for both static and slow fading wireless environments with full channel state information at the fusion center.
|
2022-12-27T23:11:32.995Z
|
235,562,493 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1246/BCSJ.20210096",
"MAG": "3159536846",
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"license": null,
"status": null,
"url": null
}
|
N5-Modified alloxazinium salts including 5-ethyl-1,3-dimethylalloxazinium and 5-ethyl-1,3-dimethyl-8-(trifluoromethyl)alloxazinium salts were readily prepared as alloxazinium-resins from the corres...
|
2022-02-07T21:16:19.483Z
|
249,587,506 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.22458/urj.v14is1.3871",
"MAG": null,
"PubMedCentral": null
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"license": "CCBY",
"status": "GOLD",
"url": "https://revistas.uned.ac.cr/index.php/cuadernos/article/download/3871/5379"
}
|
Introducción: El Parque Nacional Chirripó ha tenido cambios climáticos definidos por su ubicación y por características geológicas, geomorfológicas, ecológicas y edáficas. Objetivo: Identificar los factores que han modulado el clima en las altas cimas de Costa Rica. Métodos: Una revisión bibliográfica en Google Académico en setiembre de 2021. Resultados: El tema ha sido estudiado por la geología, geomorfología, palinología y geografía, reconstruyendo el clima durante el Último Máximo Glaciar, aproximadamente hace unos 20.000 años en el Parque Nacional Chirripó. Conocemos las condiciones climatológicas que normalmente han predominado en el parque durante las últimas décadas y cómo El Niño–Oscilación del Sur modela el clima actual. También hay modelos para proyectar las condiciones climáticas durante todo el siglo XXI en esta área protegida. Conclusión: Hay suficientes estudios del clima del parque para promocionar su geoconservación y dar mejores guías para su manejo.
|
2022-07-19T23:29:08.006Z
|
190,125,026 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4000/questionsdecommunication.5717",
"MAG": "1522971344",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://journals.openedition.org/questionsdecommunication/pdf/5717"
}
|
Art, creation, fiction. Entre sociologie et philosophie a pour source d’inspiration la rivalite d’ordre epistemologique entre la sociologie et la philosophie, la capacite a « “dire le vrai” sur l’humain » (p. 8) en constituant la question centrale. Pour Nathalie Heinich et Jean-Marie Schaeffer, cette concurrence disciplinaire relative a l’apprehension d’un meme objet est regrettable, car elle nie la condition essentielle de l’interdisciplinarite. Celle-ci, loin d’obscurcir les frontieres entr...
|
2022-07-31T03:15:24.958Z
|
245,479,754 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.18280/isi.260610",
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"license": null,
"status": "BRONZE",
"url": "https://www.iieta.org/download/file/fid/65589"
}
|
In this paper, high efficient Virtual Machine (VM) migration using GSO algorithm for cloud computing is proposed. This algorithm contains 3 phases: (i) VM selection, (ii) optimum number of VMs selection, (iii) VM placement. In VM selection phase, VMs to be migrated are selected based on their resource utilization and fault probability. In phase-2, optimum number of VMs to be migrated are determined based on the total power consumption. In VM placement phase, Glowworm Swarm Optimization (GSO) is used for finding the target VMs to place the migrated VMs. The fitness function is derived in terms of distance between the main server and the other server, VM capacity and memory size. Then the VMs with best fitness functions are selected as target VMs for placing the migrated VMs. The proposed algorithms are implemented in Cloudsim and performance results show that PEVM-GSO algorithm attains reduced power consumption and response delay with improved CPU utilization.
|
2022-07-27T21:25:02.599Z
|
210,126,232 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1155/2019/1708437",
"MAG": "2997289728",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://doi.org/10.1155/2019/1708437"
}
|
In vehicular ad hoc networks (VANETs), vehicle-to-vehicle (V2V) communication occurs opportunistically due to frequent node mobility and intermittent contact time. In this scenario, the performance evaluation of forwarding protocols by the use of the existing resources in the network is an open challenge, given the different strategies that the routing protocols adopt for choosing the next hop. Through the data analysis of three real taxis’ mobility traces and varying the radio signal range from 50 meters to 1.000 meters, we could contribute to the analysis of the existence of single-radio transmission opportunities and their quantification and classification considering either serial or parallel. Additionally, the inventory analysis of communication resources is done by evaluating the data transmission rate and the beacon overhead impact and by the proposal of a new metric (TOppMi) for the performance evaluation of forwarding protocols. We discuss the impact on forwarding protocols by the appropriate use of this metric, and we show that this metric can be used either for performance evaluation of forwarding protocols or to improve the quality over the consumption of resources in vehicular ad hoc networks. Our metric can obtain the maximum theoretical resource usage independent of the scenario. Either for Rome or San Francisco or Shanghai, as the radio’s signal range increases, the maximum theoretical amount of resources also increases. We could also show that, for the three scenarios, the beacon overhead has an insignificant impact over the total theoretical data inventory available. Furthermore, we classify the vehicles according to the contact time between them.
|
2022-10-03T14:07:54.239Z
|
242,727,671 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.1109/jestpe.2021.3102958",
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"license": null,
"status": null,
"url": null
}
|
By fully combining the advantages of line commutated converter (LCC) high-voltage direct current (HVDC) and modular multilevel converter (MMC)-HVDC systems, hybrid multiterminal HVDC (hybrid-MTDC) transmission technology has become a new technical means to overcome the shortcomings of conventional two-terminal HVDC systems. However, the conditions of high fault resistances and more sophisticated network topologies have brought considerable challenges to the existing traveling wave (TW) protection principles. In this article, a parallel hybrid-MTDC system is taken as the research object, and its mathematical analysis model is established. Based on the mathematical model, the TW characteristics that the phase of the high-frequency voltage TW during the occurrence of an internal and external fault approaches approximately 90° and 0°, respectively, are clarified. Therefore, considering the influences of reflection and refraction of TWs and line propagation, the phase-characteristics-based criterion is constructed. Using the proposed criterion, a protection scheme for hybrid-MTDC systems is proposed, which realizes the identification of line faults with high fault resistance. The proposed method is verified in detail with the electromagnetic transient simulation model using PSCAD/EMTDC, and the test results show that the proposed protection scheme is feasible and has high sensitivity, reliability, and adaptability to different operation modes.
|
2022-11-22T03:19:26.374Z
|
1,760,490 |
{
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"ArXiv": null,
"DOI": "10.1055/s-0033-1343734",
"MAG": "2166466516",
"PubMedCentral": "4176063"
},
"license": "CCBYNCND",
"status": "GOLD",
"url": "http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0033-1343734.pdf"
}
|
To improve surgical visualization and facilitate the procedure, one-lung ventilation (OLV) is frequently used during thoracic surgery. Although generally well tolerated, the ventilation–perfusion inequality induced by OLV may lead to a decrease in oxygenation and, at times, hypoxemia. Effective treatment algorithms and strategies are necessary for the treatment of hypoxemia during OLV to ensure that the technique can be continued without interruption and allow for completion of the surgical procedure. Treatment strategies may include applying positive end expiratory pressure to the nonoperative lung, continuous positive airway pressure or low flow oxygen insufflation to the operative lung, decreasing anesthetic agents that interfere with hypoxic pulmonary vasoconstriction (HPV), or switching to total intravenous anesthesia. Although less commonly employed, α-adrenergic agonists may also improve oxygenation during OLV by augmenting HPV. We present a 12-year-old girl who developed hypoxemia during OLV, which was not corrected by the usual maneuvers. Hypoxemia was successfully treated with a phenylephrine infusion. The potential applications of α-adrenergic agonists such as phenylephrine in the treatment of hypoxemia during OLV are discussed and its physiologic basis reviewed.
|
2022-12-13T23:46:02.188Z
|
254,921,194 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/OCEANS47191.2022.9977017",
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"status": null,
"url": null
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|
The rapid expansion of underwater target detection technology enables underwater operation robots to better complete underwater tasks. Therefore, a kind of underwater target detection algorithm has been pursued with its high detection accuracy and fast detection speed. One-stage target detection algorithms based on deep learning have achieved marvelous detection speed, but their detection accuracy is poor. In addition to the complex and various underwater scenes, the underwater target is extremely small in the vast ocean background. These reasons lead to the lower detection accuracy of the one-stage detection algorithm in the underwater environment. In this paper, we propose a mechanism to dynamically select feature layer channels, named DC block, so that target features on feature layers with different sizes of receptive field can be better utilized. Moreover, YOLOX, an excellent one-stage target detection network, is called YOLOX-DC after being equipped with the DC block to ensure a faster detection speed and achieve better detection accuracy. On the real-world underwater dataset, for detection and recognition of marine organisms, compared with the advanced two-stage detector Cascade R-CNN, YOLOXDC improves the detection accuracy by 0.9% mAP and the detection time latency is only 3.4% of Cascade R-CNN.
|
2022-12-23T07:25:43.207Z
|
161,311,639 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.1524/phil.1863.20.14.358",
"MAG": "1901094528",
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"license": null,
"status": null,
"url": null
}
|
e r r a t , ciiin p. 4 4 7 apud Giiufredum Grossum Vit. S . Bernundi Abbnt. T i r o n . 3 0 : „iam a navibus pontes educere , lonsiUas figere, prosnesiorum re t inacul is r a t e s s i s tere f e s t i n a b a n t " legenduin esse dicit prodensium. In eo eniin loco idem, quod Isidoro X I X , 4 , I), p. 5 8 7 : conf. Boeckh. p. 1 6 2 : Prosnesium funis , quo navis in l i tore rel igfatur ad pa ium", rest i tuenduin esse noinen prymnesium docet P a u l u s Exce rp t , ex Fes t . p. 1 2 3 : Prymnesius p a l u s , ad quem f u n i s nant icus relig:atur, quem alii tonsillam dicunt" . Q u a e sic proposita ipsa indicant id, quod moliti sumus , fecisse nos excúsate . Nec de loco Fl i i los t ra t i Imag-g. I , 1 9 , p. 3 2 , 22 alia mens fu i t Jacobsio p. 3 2 9 . Conf. L u c r e t . I I , 5 5 3 proram. cod. prosem. Friedlandiae . Rob. Unger,
|
2022-02-08T22:19:06.817Z
|
89,769,930 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.24198/JMI.V10.N1.10184.49-54",
"MAG": "2613147215",
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},
"license": null,
"status": null,
"url": null
}
|
Informasi genetik memogram semua aktivitas sel di dalam tubuh diatur dalam molekul DNA. Molekul tersebut dipandang sebagai himpunan barisan kode genetik atau kodon. Kodon merupakan suatu kode aturan penamaan asam amino berdasarkan triplet nukleotida {
|
2022-06-30T16:01:31.447Z
|
145,517,187 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4324/9780203829042-28",
"MAG": "2111672245",
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"license": null,
"status": null,
"url": null
}
|
This comprehensive volume provides an unprecedented illustration of the potential for visual methods in psychology. Each chapter explores the set of theoretical, methodological, as well as ethical and analytical issues that shape the ways in which visual qualitative research is conducted in psychology. Using a variety of forms of visual data, including photography, documentary film-making, drawing, internet media, model making, walking and map drawing, video recording and collages, each author endeavors to broaden the scope for understanding experience and subjectivity, using visual qualitative methods. The contributors to this volume work within a variety of traditions to inform the interpretations they form of their data, including narrative psychology, personal construct theory, discursive psychology and conversation analysis, phenomenology and psychoanalysis. Each addresses how a particular visual approach has contributed to existing social and psychological theory in their topic area, as well as clearly outlining how they carried out their specific research project. The contributors draw on qualitative sources of verbal data, such as spoken interview, ethnographic notes, diaries, focus group discussions and naturalistic conversation alongside their use of visual material...
|
2022-09-12T04:00:07.134Z
|
1,924,433 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.1109/TSP.2011.2169255",
"MAG": "2027195921",
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},
"license": null,
"status": null,
"url": null
}
|
The strong uncorrelating transformation (SUT) is an effective tool for blind separation of complex-valued independent sources, commonly applied to the (spatial) sample autocovariance and pseudo-autocovariance matrices of the observed mixtures. In this work we analyze the performance (in terms of the resulting interference to source ratio (ISR)) of SUT-based blind separation of general wide-sense stationary complex-valued sources. Based on a small-errors analysis, we derive explicit expressions for the attainable ISR in terms of the temporal correlations and pseudo-correlations of the sources. We demonstrate by simulation that the empirical performance closely follows our analytic prediction at moderate to long observation lengths. An important implication ensuing from our analysis is that a rectilinear (“maximally improper”) source can be perfectly separated from all the other (nonrectilinear) sources.
|
2022-09-13T22:16:22.960Z
|
31,722,510 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1073/PNAS.68.7.1501",
"MAG": "2048790548",
"PubMedCentral": null
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"license": null,
"status": null,
"url": null
}
|
From a consideration of (varphi, Psi) values of the amino acids of myoglobin, lysozyme, the alpha and beta chains of horse oxyhemoglobin, tosyl-alpha-chymotrypsin, and carboxypeptidase A, an empirical procedure of predicting whether amino-acid residues in proteins are in a non-helical or may be in a helical conformation has been developed. The conformation of an amino acid at any position n is considered to be influenced by its nearest neighbors (the amino acids at positions n + 1 and n - 1), and the (varphi, Psi) values of the middle amino acid n for the various tripeptide sequences in the known proteins are tabulated. If helical, the (varphi, Psi) values are plotted to define a helical (varphi, Psi) domain. A 20 x 20 table for all tripeptides (n - 1)-(n)-(n + 1) taken sequentially for the entire chain was constructed; it lists the number of instances in which helical and non-helical conformations for the amino acids at position n were found. Certain sequences are found to be associated exclusively with non-helical and others exclusively with helical conformations, whereas many sequences may be either helical or non-helical. The distribution of non-helical residues serves to limit stretches of permissively helical regions; these are then further examined by the helical wheel method. As applied to cytochrome c from 18 species, the only permissively helical segment found was the stretch 91-101 near the C-terminus. For the variable regions of three light and three heavy chains of immunoglobulins, upper limits of 12 and 17% alpha-helix, respectively, were obtained.
|
2022-10-28T01:07:00.813Z
|
3,878,838 |
{
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"ArXiv": null,
"DOI": "10.1002/yea.3232",
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"license": null,
"status": "CLOSED",
"url": null
}
|
In an era of ever‐increasing energy demands, a promising technology is being developed: the use of oleaginous microorganisms such as Yarrowia lipolytica to convert waste materials into biofuels. Here, we constructed two Y. lipolytica strains that displayed both increased lipid accumulation and more efficient use of biomass‐derived sugars, including glucose, fructose, galactose and inulin. The first strain, Y. lipolytica YLZ150, was derived from the French wild‐type strain W29. It had inhibited triacylglycerol mobilization (∆tgl4) and β‐oxidation (∆pox1–6), and it overexpressed GPD1, DGA2, HXK1, the native Leloir pathway, SUC2 from Saccharomyces cerevisiae and INU1 from Kluyveromyces marxianus. The second strain, Y. lipolytica Y4779, was derived from the Polish A‐101 strain. It had inhibited β‐oxidation (∆mfe2) and overexpressed GPD1, DGA1, HXK1, YHT3, SUC2 and INU1. In the first experiment, strain YLZ150 was batch‐cultured in media containing different hexoses; the highest values for lipid concentration and yield of lipids from the substrate were obtained using fructose (20.3 g dm−3 and 0.14 g g−1, respectively). In the second experiment, we grew the two strains in fed‐batch cultures to examine lipid biosynthesis from inulin (a fructose polymer). For Y4779, the lipid concentration was 10.3 g dm−3 and the yield of lipids from substrate was 0.07 g g−1; in contrast, for YLZ150, these values were 24 g dm−3 and 0.16 g g−1, respectively. The YLZ150 strain is thus able to efficiently exploit glucose, fructose, galactose, sucrose and inulin for lipid biosynthesis. Copyright © 2017 John Wiley & Sons, Ltd.
|
2022-12-04T00:20:36.770Z
|
19,883,352 |
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"DOI": "10.1213/01.ane.0000230612.29452.a6",
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|
We investigated if increasing propofol's dosage to augment its antioxidant capacity during cardiopulmonary bypass (CPB) could confer cardiac protection. Fifty-four coronary artery bypass graft surgery patients were randomly assigned to small-dose propofol (Group P; n = 18), large-dose propofol (Group HiP; n = 18), or isoflurane Group (Group I; n = 18). After the induction, anesthesia was maintained with an inspired concentration of isoflurane 1%–3.5% (Group I) or a continuous infusion of propofol 60 &mgr;g · kg−1 · min−1 (Group P) throughout the surgery. In Group HiP, this dose of propofol was increased to 120 &mgr;g · kg−1 · min−1 for 10 min before the onset of CPB until 15 min after aortic unclamping and then decreased to 60 &mgr;g · kg−1 · min−1 until the end of surgery. The duration of aortic cross-clamping was 83 ± 24, 88 ± 22, and 81 ± 20 min in Group P, Group HiP, and Group I, respectively (P > 0.1). Plasma malondialdehyde, a marker of oxidative stress, was significantly lower at 8 h after CPB, and Troponin I was lower at 24 h after CPB in Group HiP compared with Group P and Group I (P < 0.05). There was a significant reduction in inotropic requirements for separation from CPB in Group HiP compared with Group I. Postoperative systemic vascular resistance was significantly reduced in Group HiP as compared with Group I. Mean cardiac index was significantly higher at 24 h after CPB in Group HiP compared with Group P and Group I (P < 0.05) (Group I, 2.2 ± 0.1; Group P, 2.3 ± 0.2; and Group HiP, 2.8 ± 0.3 L · min−1 · m−2, respectively). The duration of intensive care unit stay was significantly shorter in Group Hi-P compared with Group I. We conclude that administration of a large dose of propofol during CPB attenuates postoperative myocardial cellular damage as compared with isoflurane or small-dose propofol anesthesia.
|
2022-12-20T14:08:24.366Z
|
231,750,645 |
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"DOI": "10.1371/journal.pbio.3001038",
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"PubMedCentral": "7837500"
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"license": "CCBY",
"status": "GOLD",
"url": "https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3001038&type=printable"
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|
Planning to speak is a challenge for the brain, and the challenge varies between and within languages. Yet, little is known about how neural processes react to these variable challenges beyond the planning of individual words. Here, we examine how fundamental differences in syntax shape the time course of sentence planning. Most languages treat alike (i.e., align with each other) the 2 uses of a word like “gardener” in “the gardener crouched” and in “the gardener planted trees.” A minority keeps these formally distinct by adding special marking in 1 case, and some languages display both aligned and nonaligned expressions. Exploiting such a contrast in Hindi, we used electroencephalography (EEG) and eye tracking to suggest that this difference is associated with distinct patterns of neural processing and gaze behavior during early planning stages, preceding phonological word form preparation. Planning sentences with aligned expressions induces larger synchronization in the theta frequency band, suggesting higher working memory engagement, and more visual attention to agents than planning nonaligned sentences, suggesting delayed commitment to the relational details of the event. Furthermore, plain, unmarked expressions are associated with larger desynchronization in the alpha band than expressions with special markers, suggesting more engagement in information processing to keep overlapping structures distinct during planning. Our findings contrast with the observation that the form of aligned expressions is simpler, and they suggest that the global preference for alignment is driven not by its neurophysiological effect on sentence planning but by other sources, possibly by aspects of production flexibility and fluency or by sentence comprehension. This challenges current theories on how production and comprehension may affect the evolution and distribution of syntactic variants in the world’s languages.
|
2022-12-23T02:13:19.097Z
|
253,524,848 |
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"DOI": "10.1101/2022.11.10.515886",
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"license": "CCBYNCND",
"status": "GREEN",
"url": "https://www.biorxiv.org/content/biorxiv/early/2022/11/12/2022.11.10.515886.full.pdf"
}
|
Spread and emergence of West Nile virus (WNV) in Europe have been very different from those observed in North America. Here, we describe key drivers by combining viral genome sequences with epidemiological data and possible factors of spread into phylodynamic models. WNV in Europe has greater lineage diversity than other regions of the world, suggesting repeated introductions and local amplification. Among the six lineages found in Europe, WNV-2a is predominant, has spread to at least 14 countries and evolved into two major co-circulating clusters (A and B). Both of these seem to originate from regions of Central Europe. Viruses of Cluster A emerged earlier and have spread towards the west of Europe with higher genetic diversity. Amongst multiple drivers, high agriculture activities were associated with both spread direction and velocity. Our study suggests future surveillance activities should be strengthened in Central Europe and Southeast European countries, and enhanced monitoring should be targeted to areas with high agriculture activities.
|
2022-11-18T00:41:24.052Z
|
244,026,644 |
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"DOI": "10.3390/admsci11040130",
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"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2076-3387/11/4/130/pdf?version=1640256825"
}
|
The public sector is facing significant challenges regarding public services provision, including declination of users’ trust and limited resources. An alternative approach to traditional public service provision with the potential to address these challenges is the co-creation of public services. Co-creation promises to foster innovative solutions to provide high-quality services that respond to users’ needs. Considering this background, we aim at critically exploring public service co-creation via a scoping review, employing the PRISMA-ScR method. Our review focuses on 25 empirical studies out of 75 analyzed articles that examine the implementation of co-creation of (digital) public services and investigates how the empirical literature portrays the concept of public service co-creation. Our findings primarily suggest that co-creation can be implemented in a wide range of sectors and settings, to improve public services and to foster innovation, throughout the whole public service cycle, using a variety of digital, analog and hybrid co-creation tools and strategies. Yet, our review has also shown that there is still an implementation gap that needs to be bridged between knowing and doing in the context of public services co-creation in a digital setting.
|
2022-10-28T01:19:54.623Z
|
172,011,561 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.21906/RBL.288",
"MAG": "2770680552",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Paul shows the power of the grace of God, which transcends all sins. Through baptism, the believer is immersed in the paschal mystery of Christ and blessed with the grace of salvation. In this paraklesis, Paul presents Christians who have passed from death to life and have become “new people.” The “old man” possessed by sin has been forever buried with Christ. In baptism, the believer is brought into union with Christ in His death, resurrection, and glorious life in God. The believer is thus enabled to open to the obedience to God and to reject evil tendencies associated with sin. The Christian becomes a soldier of God, serving in the army fighting for the freedom of the children of God and for the justice . This is possible because it is open to the grace of God.
|
2022-10-14T00:47:41.592Z
|
25,807,452 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/CARPATHIANCC.2017.7970402",
"MAG": "2728697727",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The research and use of UAVs (Unmanned Aerial Vehicles) have grown in attention and new ideas in the last couple of decades, mainly due to technology improvement of its construction parts, sensors and controllers. When it comes to its autonomous behavior, robust techniques make themselves necessary to assure the security of the aircraft and people around it. This work presents the use of computer vision techniques to improve the positioning of a quadrotor UAV in the landing moment, adding security and precision, overcoming intrinsic errors of other positioning sensors, such as GPS. A landmark was built to be detected by the camera with contour detection, image thresholding and other mathematical techniques in order to obtain fast, simple and robust processing and results. A GoPro camera model was used with a developed algorithm to remove the image distortion. With this set up, the vehicle can be programmed to develop any mission, with this works control algorithm taking part with the vision aided positioning in the landing moment. The quadrotor was conceived and built at the GRIn (Grupo de Robtica Inteligente) laboratory at UFJF (Juiz de Fora Federal University), and uses open source code for its control, with Mavlink communication protocol to exchange messages with the vision-based control algorithm for mission and landing. This algorithm was developed in Python language, and is in charge of image characteristics segmentation, extracting distances and altitude from the data. The control commands are sent to the quadrotor using the mentioned protocol. The system is structured with a remote laptop connected with a serial port to the quadrotor, and a router transmits messages back and forth among the GCS (Ground Control Station, on the laptop) and the high-level control algorithm (mission planning and vision based control) through TCP ports to the quadrotor itself. The camera is connected via Wi-Fi built-in network to the laptop, so all the image processing is done inside the last one. The results obtained in outdoor tests show the efficacy and fast processing of the vision methods and ensure safety in the landing moment. Furthermore, the positioning techniques can be extended to other UAV applications, such as transmission lines and utility equipment inspection and monitoring. Future works look forward to embedding the process in a companion board attached to the UAV, so the process would become automatic and the risk of communication interference and lost heavily reduced.
|
2022-12-16T09:45:25.057Z
|
7,902,026 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1101/GAD.196901",
"MAG": "1985843365",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
casanova (cas) mutant zebrafish embryos lack endoderm and develop cardia bifida. In a substractive screen for Nodal-responsive genes, we isolated an HMG box-containing gene, 10J3, which is expressed in the endoderm. The cas phenotype is rescued by overexpression of 10J3 and can be mimicked by 10J3-directed morpholinos. Furthermore, we identified a mutation within 10J3 coding sequence that cosegregates with the cas phenotype, clearly demonstrating that cas is encoded by 10J3. Epistasis experiments are consistent with an instructive role for cas in endoderm formation downstream of Nodal signals and upstream of sox17. In the absence of cas activity, endoderm progenitors differentiate into mesodermal derivatives. Thus, cas is an HMG box-containing gene involved in the fate decision between endoderm and mesoderm that acts downstream of Nodal signals.
|
2022-12-20T03:15:11.359Z
|
33,934,311 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/CNE.902030208",
"MAG": "2066366120",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
An attempt has been made to characterize the photoreceptors and neurons of the frontal organ of Rana pipiens and the synaptic contacts of these cells, in order to provide morphological correlates for previous physiological findings. Neurons, glial cells, and photoreceptors with two different appearances can be seen in normal anatomical preparations. The photoreceptors make ribbon synaptic contacts onto both neurons and other photoreceptors. Retrograde transport of either cobalt or horseradish peroxidase through the frontal nerve results in labeling of neurons which are often located near the exit point of the frontal nerve from the frontal organ. Some of the dendritic processes of these neurons ramify among the neurons themselves, while others ramify among the photoreceptors. In addition, the frontal organ contains two photoreceptor types which synaptically contact both neurons and other photoreceptors. In some frontal organs labeled with cobalt (but never in peroxidase‐labeled preparations) certain photoreceptors were also labeled. The labeled photoreceptors were probably the result of transcellular cobalt movement from labeled neurons, and not the result of some photoreceptors having axons in the frontal nerve. These results are discussed in conjunction with physiological evidence that chromatic interactions occur within single photoreceptors, each of which contains a single visual pigment with two physiologically active states.
|
2022-12-31T21:48:49.116Z
|
158,653,902 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.18359/RLBI.3390",
"MAG": "2804173685",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This article presents a conceptualization of same-sex marriage as the last link in marriage secularization as a social institution, which responds in turn to the process of society secularization. Accordingly, it shows how the traditional conception of marriage has spread in Latin America, which results in rejection of same-sex marriage. Finally, it expounds how its recognition is justified in terms of rights in order to build more democratic societies.
|
2022-02-08T23:38:48.675Z
|
128,474,211 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3208/JGS.5.391",
"MAG": "2020529747",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
炭酸カルシウム結晶を析出させた砂の液状化特性を明らかにするため，ゆるい炭酸カルシウム析出砂の非排水繰返し三軸試験を行った。また，析出した結晶による砂粒子間のボンディング形成の有無が液状化抵抗に及ぼす影響を調べるため，結晶析出砂を撹乱・再構成し，ボンディングの効果を除去した供試体の試験も行った。その結果，砂供試体中に析出した結晶は，ゆるい砂の液状化強度・変形特性を著しく改善することが分かった。液状化強度の増加は，結晶により形成されたボンディングが主たる要因であること，結晶析出砂の液状化強度は，正規化せん断弾性係数と液状化強度の関係を基に評価できることが明らかとなった。
|
2022-02-09T15:38:48.743Z
|
54,680,799 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1071/ASEG2018abT5_3B",
"MAG": "2789760874",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A 75 m-thick section of Early Carboniferous Tournaisian Ungani Dolomite reservoir was continuously cored in Ungani Far West 1, an appraisal well 3 km west of the Ungani field located on the southern flank of the Fitzroy Tough in the Canning Basin. The objective of this coring program was to better understand the pore systems, mineralogy, and diagenetic history of the reservoir to allow calibration and extrapolation of the petrophysical evaluation of the reservoir at the Ungani field. Petrography, stable isotopic, XRF, hyperspectral logging, grain density and CT scan studies were conducted on the core. The core consists of a 12m overlying sealing shale and 63 m of vuggy, fractured and dolomitised reservoir. The reservoir is commonly bioclastic-rich but pervasive dolomitisation hinders recognition of earlier depositional features. The upper carbonate facies is interpreted as shallow to moderate depth marine ramp-type deposits while the lower carbonate facies is suggestive of shallow platform top settings with ‘reefal’ constructing organisms. Bio-mouldic, vuggy, fracture, cavern and inter-crystalline porosity resulting from multistage brecciation, fracturing, dolomitisation and dissolution events are all present and critical to reservoir development. Based on hyperspectral logging and thin section petrography, the reservoir is predominantly dolomite with late phase cements comprising of quartz, calcite, gypsum, anhydrite, chalcedony, dickite and pyrite. Variable grain densities that correspond with porosity have been noted throughout the core but no obvious relationship between the mineralogy and porosity can be established. Shallow to moderate burial and marine or evaporative reflux fluids are likely responsible for the pervasive dolomitisation. Subsequent leaching of calcite is also key to reservoir development.
|
2022-02-11T20:50:12.319Z
|
158,855,470 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.15446/ANPOL.V31N93.75620",
"MAG": "2897521456",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Within the framework of the peace process between the Colombian Government and the FARC-EP, the Report Contribution to the Understanding of the Colombian Armed Conflict prepared by the Historical Commission of the Conflict and its Victims was presented in February 2015. A document that, by means of individual essays, investigates the origins, persistence factors and impacts of the armed conflict, and also allows us to construct an overview of the main current approaches to the issue. The article proposes a historiographic approximation to the Report, clarifying the main characteristics of the Commission that gave rise to it, balancing some debates around the conflict and peace in the country and highlighting its role as an input for a plural historical recount in a context of transition to unarmed politics.
|
2022-03-16T09:17:13.403Z
|
62,152,577 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1117/12.817903",
"MAG": "2019060797",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "http://publica.fraunhofer.de/bitstreams/5989a4a9-d9df-4bd2-a045-4ef9187ac221/download"
}
|
System concepts for network enabled image-based ISR (intelligence, surveillance, reconnaissance) is the major mission of Fraunhofer IITB's applied research in the area of defence and security solutions. For the TechDemo08 as part of the NATO CNAD POW Defence against terrorism Fraunhofer IITB advanced a new multi display concept to handle the shear amount and high complexity of ISR data acquired by networked, distributed surveillance systems with the objective to support the generation of a common situation picture. Amount and Complexity of ISR data demands an innovative man-machine interface concept for humans to deal with it. The IITB's concept is the Digital Map & Situation Surface. This concept offers to the user a coherent multi display environment combining a horizontal surface for the situation overview from the bird's eye view, an attached vertical display for collateral information and so-called foveatablets as personalized magic lenses in order to obtain high resolved and role-specific information about a focused areaof- interest and to interact with it. In the context of TechDemo08 the Digital Map & Situation Surface served as workspace for team-based situation visualization and analysis. Multiple sea- and landside surveillance components were connected to the system.
|
2022-05-19T20:29:15.563Z
|
249,773,518 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1096/fasebj.31.1_supplement.lb374",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Polycystic ovarian syndrome (PCOS) is characterized by hyperandrogenism, insulin resistance, and oligo‐ or anovulation. Insulin resistance is associated with excess weight and the elevated androgens in PCOS promote central (android) deposition of fat. This may lead to distress and healthy or unhealthy efforts to manage weight. Our purpose was to determine if women with PCOS exhibit disordered eating behaviors beyond weight‐matched controls and if eating behaviors are associated with body composition, appetite‐regulating hormones, and nutrient intake. Eight women with previously diagnosed PCOS and eight weight‐matched controls (ages 32.9 ± 3.5 and 35.0 ± 4.5 years and BMI 30.8 ± 2.1 and 30.8 ± 3.0, respectively) completed a medical and diet history questionnaire, eating attitudes test (EAT‐26), NIH diet frequency frequency questionnaire II, diet interview with a dietitian, DEXA scan, ultrasound (PCOS only), and fasting blood draw for hormone assays. Women with PCOS more frequently reported disordered eating, decreased daily food and micronutrient intakes (thiamin, folate, calcium, iron, and magnesium, with some below recommendations), and increased fat and saturated fat intakes. There were no significant differences in fasting leptin, ghrelin and insulin levels between groups. As expected the PCOS group had elevated testosterone levels (38.1 ± 7.2 and 22.7 ± 4.5 ng/dl). Contrasting correlations for some factor combinations were observed between groups. Clinically defined eating disorder in this sample of women with PCOS or weight‐matched controls was not observed, though the PCOS group had a higher average EAT‐26 score versus controls (6.4 ± 1.2 and 3.9 ± 1.6). Consistent with some other studies, trends toward subclinical disordered eating, increased nutritional risk, and dysregulation of appetite‐regulating hormones in this study merit further study.
|
2022-06-18T14:20:37.987Z
|
118,823,059 |
{
"externalids": {
"ACL": null,
"ArXiv": "1301.4471",
"DOI": "10.1103/PhysRevA.87.032110",
"MAG": "2038056104",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Photon-number correlation measurements are performed on bright squeezed vacuum states using a standard Bell-test setup, and quantum correlations are observed for conjugate polarization-frequency modes. We further test the entanglement witnesses for these states and demonstrate the violation of the separability criteria, which infers that all the macroscopic Bell states, containing typically $10^6$ photons per pulse, are polarization entangled. The study also reveals the symmetry of macroscopic Bell states with respect to local polarization transformations.
|
2022-10-19T06:05:11.374Z
|
51,653,734 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/TCE.1957.6372678",
"MAG": "2007725096",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A fairly simple theory is given and criteria have been established for analysis or design of magnetic circuits in which there are an unbalanced or d-c magnetization and a high alternating induction. High values of alternating induction and a nonlinear relation between induction B and field strength H are characteristics of magnetic circuits in power apparatus, in contrast to magnetic circuits in audio components. The relation between induction and field strength during cyclic variation is given approximately by the d-c magnetization curve of the magnetic circuit. Maximum and minimum values of induction correspond to maximum and minimum values of field strength, but the average values of B and H are not simply related. The demagnetizing effect of an alternating field superimposed upon a direct field is the reduction of average induction after the application of the alternating field. This effect is due to the nonlinearity of the magnetization function. A simple circuit using the test sample and an auxiliary transformer has been devised for obtaining data on magnetic cores by direct measurement. Test results for representative cores have been organized in a manner suitable for design use. Excitation volt-amperes, optimum per-cent gap, and core loss may be found as a function of a-c induction and unbalanced field strength. The data on magnetic materials are applicable to reactors and to transformers with unbalanced direct current such as units for supplying half-wave rectifiers. Analysis of the frequency components aids in understanding the operation of half-wave supply circuit. Only the induced voltage of the primary winding and the average secondary current affect the magnetic circuit.
|
2022-12-09T14:25:49.948Z
|
229,318,110 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/acs.est.0c06197",
"MAG": "3111724112",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The viability of airborne respiratory viruses varies with ambient relative humidity (RH). Numerous contrasting reports spanning several viruses have failed to identify the mechanism underlying this dependence. We hypothesized that an "efflorescence/deliquescence divergent infectivity" (EDDI) model accurately predicts the RH-dependent survival of airborne human rhinovirus-16 (HRV-16). We measured the efflorescence and deliquescence RH (RHE and RHD, respectively) of aerosols nebulized from a protein-enriched saline carrier fluid simulating the human respiratory fluid and found the RH range of the aerosols' hygroscopic hysteresis zone (RHE-D) to be 38-68%, which encompasses the preferred RH for indoor air (40-60%). The carrier fluid containing HRV-16 was nebulized into the sub-hysteresis zone (RHD) air, to set the aerosols to the effloresced/solid or deliquesced/liquid state before transitioning the RH into the intermediate hysteresis zone. The surviving fractions (SFs) of the virus were then measured 15 min post nebulization. SFs were also measured for aerosols introduced directly into the RHD zones without transition. SFs for transitioned aerosols in the hysteresis zone were higher for effloresced (0.17 ± 0.02) than for deliquesced (0.005 ± 0.005) aerosols. SFs for nontransitioned aerosols in the RHD zones were 0.18 ± 0.06, 0.05 ± 0.02, and 0.20 ± 0.05, respectively, revealing a V-shaped SF/RH dependence. The EDDI model's prediction of enhanced survival in the hysteresis zone for effloresced carrier aerosols was confirmed.
|
2022-12-22T17:38:17.803Z
|
254,964,112 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/geroni/igac059.2351",
"MAG": null,
"PubMedCentral": "9767251"
},
"license": null,
"status": "GREEN",
"url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9767251"
}
|
Abstract Background Family members often take on the caregiver roles to stroke survivors due to kinships and cultural responsibilities. Yet, little is known about the the impact of survivor-caregiver dynamics on stroke rehabilitation. To understand the dyadic relationships between the dyads, a systematic review was conducted to examine studies which have adopted Actor–Partner Interdependence Model (APIM) analysis. Methods A systematic review and meta-analysis were conducted using the following electronic databases: PubMed, SAGE Journals, MEDLINE, PsycINFO and Cochrane Review to identify eligible studies published from their inception to December 2021, following the PRISMA guidelines. Results Nine studies involving 1183 stroke survivors (male = 57%) and 1181 caregivers (male = 37%) had met the inclusion criteria and were identified in this review. The interaction among the following outcomes were self-esteem, optimism, stress, depression, emotional distress, quality of life, and life satisfaction. The review provided evidence that (1) APIM is valuable tool in analyzing dyadic interactions; (2) support from caregivers has a significant impact on the stroke survivor’s recovery; (3) the mental health status of caregivers can influence that of stroke survivors and vice versa; (4) Due to the interconnected nature of dyadic interaction, providing dyadic intervention have positive impact on dyads. Conclusion These findings highlight the interdependence nature between survivor-caregiver dyads in the context of stroke rehabilitation. The APIM provides conclusive evidence on the effectiveness of survivor-caregiver dyadic interactions, with significant theoretical and practice implications for both health and social care professions. More research is needed to support dyadic strategies for stroke survivors.
|
2022-12-30T00:38:19.082Z
|
108,600,430 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2172/968580",
"MAG": "1515242306",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://digital.library.unt.edu/ark:/67531/metadc931442/m2/1/high_res_d/968580.pdf"
}
|
This report describes the current capabilities of the INL to manage the NHI, the planned increases in capability to support NHI, and the cost and schedule and strategy for developing a commercially viable hydrogen production technology for deployment with NGNP.
|
2022-07-11T03:13:48.671Z
|
252,966,387 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.33590/emjcardiol/10311956",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBYNC",
"status": "GOLD",
"url": "https://emj.emg-health.com/wp-content/uploads/sites/2/2019/10/Cardiac-Rehabilitation-in-Heart-Failure-Looking-Further-Ahead.pdf"
}
|
Heart failure (HF) is associated with significant morbidity and mortality. Despite major advances in the treatment of HF, there are still important unmet needs among this patient population. Cardiac rehabilitation has a central role in cardiovascular prevention and for overall disease management, and can have an important impact among HF patients. The authors present a brief overview on the current role of cardiac rehabilitation among HF patients in a contemporary setting and discuss some areas of future research in the context of this intervention.
|
2022-10-21T00:06:07.749Z
|
2,906,862 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/CM.970180307",
"MAG": "2171363772",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Experiments were carried out to elucidate changes in cytoskeletal elements and intercellular junctions in the organ of Corti, when hair cells degenerate and phalangeal scars form. Hair cell damage was induced by exposing guinea pigs to high intensity noise. The spatial and temporal changes in the organization of microfilaments, intermediate filaments, and tight junction-specific proteins were investigated using scanning and transmission electron microscopy and histochemistry. The results show that microfilaments, cytokeratins, adherens junctions, and tight junctions rearrange their distribution in damaged areas. From the temporal sequence of these changes it appears that phalangeal scars develop simultaneous with hair cell degeneration, and that the integrity of the luminal membranes in the organ of Corti is not interrupted. Each scar is formed by two supporting cells which expand and invade the sub-apical region of the dying hair cell. This region becomes cytokeratin-positive. The two supporting cells meet at the mid-line of the scar, where a new junctional complex is formed. The junctional complex consists of tight junction and adherens-type junction, but desmosomes are absent.
|
2022-12-25T04:23:59.602Z
|
56,467,099 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/2013WR015187",
"MAG": "2002688354",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Human water use is increasing and, as such, water for the environment is limited and needs to be managed efficiently. One method for achieving this is the scheduling of environmental flow management alternatives (EFMAs) (e.g., releases, wetland regulators), with these schedules generally developed over a number of years. However, the availability of environmental water changes annually as a result of natural variability (e.g., drought, wet years). To incorporate this variation and schedule EFMAs in a operational setting, a previously formulated multiobjective optimization approach for EFMA schedule development used for long‐term planning has been modified and incorporated into an adaptive framework. As part of this approach, optimal schedules are updated at regular intervals during the planning horizon based on environmental water allocation forecasts, which are obtained using artificial neural networks. In addition, the changes between current and updated schedules can be minimized to reduce any disruptions to long‐term planning. The utility of the approach is assessed by applying it to an 89km section of the River Murray in South Australia. Results indicate that the approach is beneficial under a range of hydrological conditions and an improved ecological response is obtained in a operational setting compared with previous long‐term approaches. Also, it successfully produces trade‐offs between the number of disruptions to schedules and the ecological response, with results suggesting that ecological response increases with minimal alterations required to existing schedules. Overall, the results indicate that the information obtained using the proposed approach potentially aides managers in the efficient management of environmental water.
|
2022-12-25T17:33:22.022Z
|
223,436,419 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3760/CMA.J.ISSN.0254-9026.2015.02.004",
"MAG": "3032885369",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Objective
To investigate the effect and safety of primary percutaneous coronary intervention (PCI) of acute ST-segment elevation myocardial infarction (STEMI) in elderly patients.
Methods
103 consecutive patients with STEMI treated by primary PCI were divided into two groups according to the age: the elderly group 〔aged≥65 years, with a mean age of (75.7±6.2) years(n = 49), the non-elderly group 〔aged<65 years, with a mean age of (43.0±8.6) years(n = 54). Clinical characteristics, complications related to PCI procedure and success rate were analyzed, and major cardiovascular events (MACE) were followed up for(5.7±1.2)months.
Results
The proportion of female, patients with Killip ≥Ⅲ, three vessels disease and higher level of serum brain natriuretic peptide were higher in elderly group than in non-elderly group (all P 0.05). Patients were followed up for (5.7±1.2) months. The in-hospital and one-month mortalities were higher in elderly group than in non-elderly group 〔8.2% (4 cases)vs. 0% (0 case), 10.2%(5 cases) vs. 0 % (0 case), respectively, all P<0.05〕. There was no significant difference in six-month mortality and MACE between the two groups. Multivariate logistic regression analysis showed that Killip ≥Ⅲ was related with the increase of one-month mortality in patients with STEMI undergoing primary PCI, whereas age was not.
Conclusions
Primary PCI is effective and safe in elderly patients with STEMI.
Key words:
Myocardial infarction; Angioplasty, transluminal, Percutaneous cornary
|
2022-02-08T00:37:03.687Z
|
207,604,757 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1159/000335527",
"MAG": "1987534320",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
dysfunction with the typical complications of advanced heart failure. For adult congenital cardiologists the care of failing Fontans represents a challenge. Indeed the Fontan procedure has been cited as providing, inadvertently, job security for adult congenital cardiologists. The myriad of late complications of the Fontan circulation have led some congenital cardiologists to describe it as ‘a mistake’ that we should consider undoing and reconsider performing in the first place. While most congenital cardiologists believe the Fontan is flawed, most have not reached the damning position that it should be abandoned. In the midst of this ambivalence and debate there is one important voice that, until now, has not been heard, the voice of the patients. In a recent issue of Cardiology Overgaard et al. [1] report on ‘Patient-reported outcomes in adult survivors with single-ventricle physiology’. The authors solicited information about functional status and a variety of indices pertaining to perceived health, quality of life, anxiety and depression, and sense of coherence. Though not all patients had total cavopulmonary connection they are a substantial majority (82%). The patient-reported outcomes are compared to a well-matched randomly selected control group of healthy volunteers. The significant findings include a correlation between The total cavopulmonary connection or Fontan procedure has become the palliation of choice for children born with hearts that are not compatible with a two-ventricle repair. These typically occur as a consequence of inadequate development of the right or left ventricle. Conditions such as tricuspid atresia, hypoplastic left heart from mitral or aortic atresia, double-inlet single ventricle, pulmonary atresia with intact ventricular septum and hypoplastic right heart cannot be converted to separate pulmonic and systemic circulations with two ventricles. A direct anastomosis between systemic veins and the pulmonary arteries, in an appropriate hemodynamic setting, provides relief from cyanosis with relatively stable, adequate cardiac output at the cost of elevated systemic venous pressure. In the immediate and short term this is a good deal. Patients who have had total cavopulmonary shunts lead surprisingly normal lives, though with reduced exercise capacity. The deal tends to become less good with time. Chronically elevated systemic venous pressure leads to venous thrombosis, hepatic congestion with cryptogenic cirrhosis, atrial tachycardias – particularly in the earlier iterations of the shunt – with arterial thromboembolism, protein-losing enteropathy and plastic bronchitis. A substantial proportion of these patients also develop systolic ventricular Received: December 2, 2011 Accepted: December 3, 2011 Published online: January 20, 2012
|
2022-01-27T01:43:35.105Z
|
241,410,906 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.33142/hst.v4i1.3478",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBYNC",
"status": "GOLD",
"url": "https://journals.viserdata.com/index.php/hst/article/download/3478/3429"
}
|
临泉县，隶属安徽省阜阳市，是安徽省的西北门户，位于黄淮平原的西南端，安徽省的西北部。地理位置介于东经114°50′～115°31′，北纬32°35′～33°09′之间。与皖豫两省9个县市区接壤，总面积1839平方公里。截至2019年末，临泉县户籍人口230.7万。临泉县河流密布，交通便利。南临洪河，北依泉河，中有谷河、润河、涎河、流鞍河自然河道穿境东流，又有临艾河、界南河人工河道横贯南北。临泉县河流属淮河水系，境内分4个小水系。我县原有中小型水闸涵闸多数为上世纪六、七十年代投资兴建，当时设计标准低，施工工艺落后，水泥等建筑材料紧缺，大多为浆砌砖结构，经过几十年的运行，现在多数已成病险建筑物。加之内河河道多年未进行疏浚治理，淤积严重。已不能发挥应有效益。近年来，我国综合实力的快速提升，从而有效加大了基础建设的快速投入，为各个领域的发展壮大带来了良好的机遇，为了切实的解决上述问题，我们水利行业也加大了水利工程建设工作力度，临泉县老集闸、黄岭闸、长官闸、东风闸、焦桥闸、谢集闸等水闸已鉴定为四类闸，已列为全省大中型涵闸除险加固项目，从2013年8月开始逐年实施，笔者也荣幸的成为一名水利工程建设的见证者和参与者。根据笔者多年的水利工程建设管理工作体会，在当前水利工程中，水闸建设是水利行业较为关键的一个部分，水闸结构的质量与工程施工质量密切相关，所以需要我们加以重点关注。但是因为受到多方面因素的影响，使得人们对于经济效益过分的追求，从而忽视了水利工程水闸施工质量的管控，使得大量的施工质量问题层出不穷，不仅对整个水利水电工程行业的发展壮大造成了诸多的限制，并且也对我国社会经济的发展形成了阻碍。为此，国家实行建设项目法人，认真落实“项目法人负责、监理单位控制、施工单位保证、政府部门监督”四位一体的质量管理体系。
|
2022-01-27T02:14:38.843Z
|
250,938,837 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.54691/bcpbm.v21i.1288",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "HYBRID",
"url": "http://bcpublication.org/index.php/BM/article/download/1288/1293"
}
|
This article first analyzes the international business development of internationally renowned energy companies such as EDF and PetroChina. Then, summarize the international development experience of large energy companies, hoping to provide a reference for Chinese energy companies to expand into the international market.
|
2022-07-31T07:59:52.534Z
|
10,618,556 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/jb/mvr086",
"MAG": "1966531793",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We tested the capsid targeted viral inactivation method as an anti-HBV strategy. HepG2 cells were cotransfected with HBV expression plasmid and the plasmid encoding fusion protein of either Core-A3C or Core-humanized renilla GFP (hrGFP). Core-A3C had substantial effect on HBV DNA levels. In the HepG2 cells expressing Core-A3C, the number of G-to-A mutations increased dramatically, whereas other nucleotide substitutions were rare. In addition, Core-A3C substantially inhibited HBV production intracellularly and in culture supernatant. These results suggest that Core-A3C may be a candidate as a novel antiviral agent against human HBV infection.
|
2022-09-11T14:48:15.117Z
|
119,927,773 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/PLASMA.2005.359463",
"MAG": "2004541555",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Summary form only given. Coherent terahertz Smith-Purcell radiation, typically formed by a relativistic bunch moving above a periodic grating, is characterized by a broad spectrum of frequencies which depend on the observation angle. It can be used as a bunch length diagnostic technique by measuring, on a relative scale, the radiated power versus the observation angle and determining the cut-off frequency. For short bunches in the order of 100 microns this method requires broadband detectors at terahertz frequencies in addition to mechanical means for scanning at the different observation angles. An exact calculation of the radiated power on an absolute scale could be used as a simple method for bunch length diagnostics having the features of a real-time measurement at a single observation angle at the millimeter-wave regime. An exact model of Smith-Purcell radiation from a charged particle moving above a finite-length grating will be presented following an update on the experimental status.
|
2022-12-14T14:39:02.195Z
|
110,752,553 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1108/17410381211230448",
"MAG": "2039677679",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "http://mdh.diva-portal.org/smash/get/diva2:486651/FULLTEXT02"
}
|
Purpose – The purpose of this paper is to describe the underlying design information and success factors for production equipment acquisition, in order to support the design of high‐performance production systems.Design/methodology/approach – The research strategy employed was an in‐depth case study of an industrialization project, together with a questionnaire of 25 equipment suppliers.Findings – The study provides the reader with an insight into the role of design information when acquiring production equipment by addressing questions such as: What type of information is used? How do equipment suppliers obtain information? What factors facilitate a smooth production system acquisition?Research limitations/implications – Limitations are primarily associated with the chosen research methodology, which requires further empirical studies to establish a generic value.Practical implications – The implications are that manufacturing companies have to transfer various types of design information with respect to...
|
2022-12-15T03:45:45.737Z
|
13,088,571 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/molbev/msv122",
"MAG": "2102134701",
"PubMedCentral": "4540971"
},
"license": "implied-oa",
"status": "HYBRID",
"url": "https://academic.oup.com/mbe/article-pdf/32/9/2219/13166911/msv122.pdf"
}
|
Spliceosomal introns are a hallmark of eukaryotic genes that are hypothesized to play important roles in genome evolution but have poorly understood origins. Although most introns lack sequence homology to each other, new families of spliceosomal introns that are repeated hundreds of times in individual genomes have recently been discovered in a few organisms. The prevalence and conservation of these introner elements (IEs) or introner-like elements in other taxa, as well as their evolutionary relationships to regular spliceosomal introns, are still unknown. Here, we systematically investigate introns in the widespread marine green alga Micromonas and report new families of IEs, numerous intron presence–absence polymorphisms, and potential intron insertion hot-spots. The new families enabled identification of conserved IE secondary structure features and establishment of a novel general model for repetitive intron proliferation across genomes. Despite shared secondary structure, the IE families from each Micromonas lineage bear no obvious sequence similarity to those in the other lineages, suggesting that their appearance is intimately linked with the process of speciation. Two of the new IE families come from an Arctic culture (Micromonas Clade E2) isolated from a polar region where abundance of this alga is increasing due to climate induced changes. The same two families were detected in metagenomic data from Antarctica—a system where Micromonas has never before been reported. Strikingly high identity between the Arctic isolate and Antarctic coding sequences that flank the IEs suggests connectivity between populations in the two polar systems that we postulate occurs through deep-sea currents. Recovery of Clade E2 sequences in North Atlantic Deep Waters beneath the Gulf Stream supports this hypothesis. Our research illuminates the dynamic relationships between an unusual class of repetitive introns, genome evolution, speciation, and global distribution of this sentinel marine alga.
|
2022-12-19T13:53:17.676Z
|
220,858,884 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3760/CMA.J.ISSN.0254-6450.2011.02.023",
"MAG": "3028945950",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
乙型肝炎（乙肝）病毒（HBV）感染是全球性公共卫生问题，中国慢性乙肝表面抗原（HBsAg）携带者达1亿多，其中1／3以上是母婴传播所致。孕期肝细胞内HBV复制加重肝脏负担，可能诱发相关妊娠并发症。本研究回顾性地分析杭州地区孕妇HBV携带及其对妊娠并发症、分娩方式、母婴传播及婴儿喂养的影响。
|
2022-02-08T01:22:44.270Z
|
109,358,248 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/EMPD.1998.705523",
"MAG": "1730975555",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper presents a general formulation of the optimum economic load dispatch problem in a system with thermal plants taking into account the constraints on emission of sulfur dioxide and oxides of nitrogen. The proposed algorithm is useful to determine the optimum mix-ratio of high sulfur content and low sulfur content fuels, to limit the sulfur dioxide (SO/sub 2/) emission per hour. The emission of oxides of nitrogen (NO/sub x/) is minimised by reducing the output of the generating units with the high ratio of incremental NO/sub x/ emission to incremental fuel cost. The method proposed for considering the pollution constraints is simple, and can easily be incorporated in an existing economic dispatch program. The algorithm is tested on a plant with four generating units, and the results are presented.
|
2022-03-03T07:14:01.565Z
|
240,898,282 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.35940/ijeat.c6398.049420",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://doi.org/10.35940/ijeat.c6398.049420"
}
|
This paper proposes an efficient monitoring system for toddlers, with wireless communication based on IoT technology. A prototype is developed which gives a reliable and efficient toddler monitoring system that can play an important role in providing better toddler care. This structural set-up monitors and display the essential parameters such as range of temperature and humidity content and heart pulse range in bpm also the movement of a toddler and this information is conveyed to their parents. The main reason for choosing this kind of system for their toddler is to give a comfort and contentment to the loved ones when they are away from their toddler as they can get update status of their well beings. The whole prototype will be working on the basis of a single controller which controls the entire system to provide the precise output extended its advancements to the cloud storage which provides easy access and increased memory and efficiency. The other advantageousness is the scheduling of alarm conditions can take the edge off any imprecision through a conventional sensor. Communication is done by cyberspace which is need and uncomplicated accessible thing.
|
2022-03-25T01:24:55.965Z
|
119,376,903 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1600-0870.2007.00282.x",
"MAG": "2000583137",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A bottom mounted ADCP has monitored the ice motion and thickness in Bothnian Bay, Baltic Sea during the entire winter season 2004. The ADCP was deployed at 20 m depth at Falkensgrund well outside the land fast ice zone. The data shows that the ice motion is primarily driven by the wind but with a clear influence of internal ice stresses. The ice stresses become more dominant as the ice grow thicker with increasing number of observations with nearly stationary ice for relatively high wind speeds. A clear dependence of the ice/wind speed ratio to wind shifts is detected with higher ratio in the new wind direction. The effect of strain hardening is also seen in several events as decreasing ice speed, sometimes to zero, in spite of constant wind speed and wind direction. A rough force balance computation gives a compressive ice strength of about 9 × 104 Nm−2, which is much larger than normally used in numerical ice models. The ice thickness data show numerous ice ridges with ice draft well above 1 m passing the instrument. The ridges make up a large portion, 30–50%, of the total ice volume showing that dynamical processes are important for the total ice production in the Bothnian Bay.
|
2022-09-11T13:09:20.687Z
|
245,388,135 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/WiPDA49284.2021.9645127",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Wide bandgap devices in combination with TCM (for soft switching) are typically applied in inverters to achieve high power density and efficiency. This has the disadvantage of a huge current ripple during sinusoidal peak. DPWM counteracts this problem by avoiding switching actions in this section. Due to the rapidly changing voltage across the output capacitors, oscillations within the filter may occur when entering DPWM interval. This current peak can saturate the inductor and the output voltage is distorted as well. This paper proposes a method to mitigate these oscillations by bringing the capacitor voltages to the required voltage prior DPWM interval. Compared to conventional TCM modulation, lower losses result. By damping the oscillations induced by DPWM it is suitable for grid and motor applications.
|
2022-10-20T18:25:50.633Z
|
226,947,723 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/cbdv.202000560",
"MAG": "3106329629",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Allium species are widely consumed as food all over the world. The phenolic profile of ethanol extracts of aerial parts and roots of 12 Allium species, collected from five different Eastern Anatolia regions, were studied using LC‐MS/MS. In vitro antioxidant, anticholinesterase, cytotoxic and antimicrobial activities were also tested. The multivariate analyses were performed using principal component and hierarchical cluster analyses. Seventeen of 27 standard compounds were detected in all Allium species. The major components were mainly identified as quinic acid, malic acid, vanillin, and p‐coumaric acid. The aerial parts possessed better antioxidant activity than roots. Aerial parts of A. atroviolaceum, A. chrysantherum, A. kharputense, and A. shirnakiense exhibited high cytotoxic activity against DLD‐1 colon cancer cell lines (IC50 12.5 μg/mL). A. shatakiense and A. vineale demonstrated good antimicrobial activity against S. aureus and E. coli (MIC 75 μg/mL). According to chemometric analysis, differences were detected between aerial parts and the roots. The aerial parts of A. atroviolaceum, A. chrysantherum, A. kharputense, and A. shirnakiense could be potent in the pharmaceutical industry while A. shatakiense and A. vineale in the food industry after further investigations.
|
2022-12-11T02:55:03.412Z
|
3,567,770 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/mpp.12406",
"MAG": "2331392637",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://bsppjournals.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/mpp.12406"
}
|
The oomycete Phytophthora capsici is a plant pathogen responsible for important losses to vegetable production worldwide. Its asexual reproduction plays an important role in the rapid propagation and spread of the disease in the field. A global proteomics study was conducted to compare two key asexual life stages of P. capsici, i.e. the mycelium and cysts, to identify stage-specific biochemical processes. A total of 1200 proteins was identified using qualitative and quantitative proteomics. The transcript abundance of some of the enriched proteins was also analysed by quantitative real-time polymerase chain reaction. Seventy-three proteins exhibited different levels of abundance between the mycelium and cysts. The proteins enriched in the mycelium are mainly associated with glycolysis, the tricarboxylic acid (or citric acid) cycle and the pentose phosphate pathway, providing the energy required for the biosynthesis of cellular building blocks and hyphal growth. In contrast, the proteins that are predominant in cysts are essentially involved in fatty acid degradation, suggesting that the early infection stage of the pathogen relies primarily on fatty acid degradation for energy production. The data provide a better understanding of P. capsici biology and suggest potential metabolic targets at the two different developmental stages for disease control.
|
2022-12-15T14:14:48.788Z
|
13,832,720 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3892/ijmm.2018.3636",
"MAG": "2799890694",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://www.spandidos-publications.com/10.3892/ijmm.2018.3636/download"
}
|
miR‑152 has been reported to be downregulated in rheumatoid arthritis (RA). However, the functional significance and molecular mechanisms underlying the role of miR‑152 in RA remain largely unknown. The present study aimed to explore the functional role and the underlying mechanisms of miR‑152 in RA. The expression of miR‑152 in serum, synovial tissues, and fibroblast‑like synoviocytes (FLS) from patients with RA and healthy controls was detected by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR). Cell proliferation, cell cycle phase distribution and apoptosis of FLS were measured by Cell Counting Kit‑8 and flow cytometry assays. The effects of miR‑152 on the production of pro‑inflammatory cytokines, including tumor necrosis factor (TNF)‑α, interleukin (IL)‑1β, IL‑6 and IL‑8, were examined by ELISA. The target gene of miR‑152 was discovered by miRNA‑target prediction bioinformatics analysis, and confirmed by dual‑luciferase reporter assay, RT‑qPCR and western blotting. Spearman's correlation analysis was performed to assess the relationship between miR‑152 expression and a disintegrin and metalloproteinase domain‑containing protein 10 (ADAM10). The results demonstrated that miR‑152 expression levels were significantly decreased in RA serum, synovial tissues and RA‑FLS compared with healthy controls. Overexpression of miR‑152 significantly inhibited cell proliferation, promoted cell apoptosis, and decreased TNF‑α, IL‑1β, IL‑6 and IL‑8 production in RA‑FLS cells. Additionally, ADAM10 was demonstrated to be a target of miR‑152, and expression of the two genes was significantly negatively correlated. Of note, restoration of ADAM10 expression partially reversed the effects of miR‑152 on cell proliferation and apoptosis in RA‑FLS. Thus, miR‑152 may serve as a potential target for therapeutic intervention in RA.
|
2022-12-19T01:07:24.525Z
|
222,285,497 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1215/00182168-64.3.443",
"MAG": "2315739784",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://read.dukeupress.edu/hahr/article-pdf/64/3/443/729129/0640443.pdf"
}
|
EFORE the outbreak of the Mexican Revolution in 1g9o, over half of all railroad workers participated in labor unions, making the railroads the most highly organized industry in Mexico. An examination of this development provides a vital insight into the growth of labor associations and the complexities of government labor policy in dependent countries. In Mexico, as in other Latin American nations, foreign companies and managers controlled the railroads by the turn of the century. In the early stages of operation, these companies, along with those in the mining and smelting industries, brought in foreign skilled workers who soon monopolized the betterpaying positions. What appears to distinguish the railroad industry is the presence of United States labor unions that came to Mexico, not to organize Mexican workers, but to protect United States workers who were in Mexico in sufficient numbers to warrant opening local chapters there.' These railroad brotherhoods affected not only the development of Mexican labor associations in the industry but also the government's labor policy under Porfirio Diaz. The nature of the Mexican labor associations during the Porfiriato
|
2022-12-20T15:23:26.777Z
|
115,606,551 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.24033/ASENS.1220",
"MAG": "39003767",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
© Gauthier-Villars (Éditions scientifiques et médicales Elsevier), 1972, tous droits réservés. L’accès aux archives de la revue « Annales scientifiques de l’É.N.S. » (http://www. elsevier.com/locate/ansens) implique l’accord avec les conditions générales d’utilisation (http://www.numdam.org/conditions). Toute utilisation commerciale ou impression systématique est constitutive d’une infraction pénale. Toute copie ou impression de ce fichier doit contenir la présente mention de copyright.
|
2022-10-28T00:05:45.080Z
|
153,488,406 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/13501760802589404",
"MAG": "2017352465",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This article outlines how the notion of an EU timescape may be developed into a fruitful research agenda. It sets out central tasks involved, including clarification of the concept of an EU timescape; of the key empirical questions to be asked; and of the status of political time in variable-oriented research. The article illustrates the potential value-added of a time-centred approach to the study of the EU by highlighting temporal issues in EU enlargement, differentiated integration and democratization. It concludes with thoughts on the comparison of democratic timescapes.
|
2022-12-11T12:29:37.429Z
|
209,591,068 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2116/BUNSEKIKAGAKU.43.31",
"MAG": "111315750",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
臭化物イオンを含む鉄(III)-鉄(II) 混合液から成る電位緩衝液と酸化還元電極(ORP) 検出器を用いて,迅速で高感度なクロム(VI) のフローインジェクション電位差分析法を開発した.分析の基本原理は,電位緩衝液とクロム(VI) との酸化還元反応において生じる短時間かつ過渡的で鋭敏なORP電極の電位変化量が,クロム(VI) 濃度に比例することを利用したものである.過渡的な電位変化は,臭化物イオンとクロム(VI) との反応を鉄(II)イオンが誘導し,その結果生成した臭素に起因することを,吸収スペクトル法により明らかにした.本法では,この電位変化をタイミングよく検出することにより,臭化物イオンを含まない緩衝液を用いた場合に比べて約70倍高い分析感度を得た.電位緩衝液中の鉄(III)-鉄(II)濃度を低くするに従い,検出感度は増大し,1×10-4Mの場合には,濃度10-7Mレベルのクロム(VI)の定量が可能で,S/N比3で検出下限濃度は2×10-8 M (2ppb) であった.分析処理速度は1時間当たり約40試料で,1×10-6M クロム(VI) の定量に対する相対標準偏差は0.6%(n=6) であった.又, 本法を海水中のクロム(VI)の定量に応用した結果,海水中の排水基準濃度レベル(500ppb 程度)のクロム(VI) の定量において良好な回収率を得た.
|
2022-12-14T11:12:41.048Z
|
467,020 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/03079459008418721",
"MAG": "2168982500",
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},
"license": null,
"status": null,
"url": null
}
|
Liver collected aseptically from broiler chickens suffering from natural outbreaks of hydropericardium syndrome was homogenised in phosphate buffered saline (1:5) or normal saline (1:10). A dose of 0.25 ml of 800 g supernatant (inoculum S) in the first case or homogenate without centrifugation (inoculum T) in the second case was injected subcutaneously into 12- to 15-day-old broiler chickens. Lesions similar to natural outbreaks of the syndrome appeared in 2 to 5 days. Inoculum S inactivated with 0.1% formalin for 24 h (Vac S) or inoculum T inactivated with 0.5% formalin for 72 h (Vac T) was injected into commercial broiler chickens at 10 or 15 days of age. The birds were challenged with inoculum S or inoculum T at 20 or 25 days of age. Experimentally both vaccines gave satisfactory protection, but under field conditions, Vac T was superior.
|
2022-12-18T22:50:24.389Z
|
149,164,721 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.24912/JK.V8I2.63",
"MAG": "2619631071",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRAK: Suatu studi eksploratif mengenai penggunaan infografis sebagai media komunikasi kebijakan dapat membentuk ketertarikan situasi, pemahaman situasi, dan cara berperilaku publik non-ahli ekonomi terhadap informasi kebijakan ekonomi Bank Indonesia yang kompleks. Studi ini menggunakan metode penelitian gabungan dan konsep teori ‘ Medium is The Message ’ dari Marshall McLuhan. Sampel dalam penelitian ini sebanyak lima belas (15) orang dengan menggunakan teknik purposive sampling . Hasil penelitian dan simpulan penelitian yaitu infografis Bank Indonesia sudah cukup baik dalam membentuk ketertarikan situasional publik. Namun, masih terdapat beberapa aspek yang harus diperbaiki agar dapat memaksimalkan ketertarikan publik. Pada pemahaman situasional, infografis belum mampu membentuk pemahaman publik. Permasalahan ini disebabkan oleh masih banyak terdapatnya bahasa ekonomi dan keterbatasan pengetahuan umum publik mengenai dunia ekonomi. Terakhir, cara berperilaku publik terhadap informasi ekonomi belum dapat terbentuk karena tidak tercapainya pemahaman situasional oleh publik. Meskipun begitu, publik memiliki keinginan dan harapan yang cukup baik terhadap perekonomian Indonesia. ABSTRACT: An exploratory design about the use of infographic as an communication medium can establish situational interest, situational understanding, and public behavior by non-experts towards the information of economics complex policy. This study used Mixed Methods and Medium is The Message Theory propounded by Marshall McLuhan. The sample of this study is fifteen (15) people and use purposive sampling as the sampling technique. The results and conclusions of this research shows that infographic of Bank Indonesia has been good-enough on establishing situational interest by public. However, there is still room for improvement that can optimize more public interest. In situational understanding, infographic has not been good-enough to establish situational understanding. This problem is caused by the presence of many economics terms and languages in the infographic and the limitation of economics knowledge by the public. Lastly, the public behavior towards economics information can not be established due to the unsuccessful forming of situational understanding by the public. Even so, the public still has the desire and hope towards the economics of Indonesia. The public is willing to get involved in the efforts to maintain and improve the economics of Indonesia.
|
2022-12-18T18:00:44.551Z
|
137,088,328 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.4028/www.scientific.net/KEM.396-398.119",
"MAG": "2063127901",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Sol-gel derived glasses have been reported to express considerably higher bioactivity than melt-derived ones. The use of the sol-gel method for the fabrication of dental ceramic bioactive glass composites has resulted in composites consisting of an amorphous glassy network into which crystals of Calcium Silicate (CS), Wollastonite (W), leucite (Lt) and Fluorapatite (FAp) are dispersed. Thus, the aim of the present study was the investigation of the bioactivity of sol-gel derived dental ceramic/bioactive glass composites, in the form of powders and in thermally treated disk shaped specimens. Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM) were used to characterize the reacted products. The sol-gel derived dental glass ceramic composites present high bioactivity compared to the respective melt-derived ones, which is attributed to the higher CaO content and the crystallization of bioactive W and CS crystal phases during the fabrication process. However, the powdered samples presented faster HCAp formation compared to the respective specimens, due to their higher surface energy.
|
2022-02-09T10:47:23.230Z
|
53,758,714 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1037/adb0000425",
"MAG": "2748481985",
"PubMedCentral": null
},
"license": "CCBYNCND",
"status": "GREEN",
"url": "https://open.library.ubc.ca/media/download/pdf/24/1.0354262/4"
}
|
The “winner–loser effect” refers to a phenomenon in testosterone research where the outcome of a social competition induces increases (wins) and/or decreases (losses) in testosterone levels. Here, we sought to test to what extent changes in testosterone occur in response to gambling behavior. More specifically, we hypothesized that the winner–loser effect would extend to slot machine gambling as a solitary (noncompetitive) gambling activity in players who “anthropomorphized” the slot machine, thus treating the machine as a human opponent. Male participants (n = 113) were recruited into a quasi-experimental design involving 15 min of authentic slot machine gambling, incentivized by a $10 cash bonus for participants who finished in profit. In addition to salivary measures of testosterone, salivary cortisol and self-reported anthropomorphization of the slot machine were tested as potential moderators. Contrary to predictions, winning and losing slot machine sessions did not exert significant differential effects on testosterone, and this pattern was not moderated by cortisol levels or slot machine anthropomorphization. Exploratory analyses tested relationships between subjective gambling experiences in the sessions and testosterone change. Higher positive affect and flow predicted greater testosterone declines from pre- to postgambling. The testosterone results add to a growing literature on the boundary conditions of the winner–loser effect and inform future studies on testosterone reactivity in relation to gambling and disordered gambling. The tendency to anthropomorphize slot machines is a neglected cognitive distortion in gambling that merits further study.
|
2022-09-02T13:19:27.033Z
|
245,385,381 |
{
"externalids": {
"ACL": null,
"ArXiv": "2112.11991",
"DOI": "10.1093/mnras/stab3746",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "HYBRID",
"url": "https://academic.oup.com/mnras/article-pdf/511/1/1265/42416748/stab3746.pdf"
}
|
Relativistic binary pulsars orbiting white-dwarfs and neutron stars have already provided excellent tests of gravity. However, despite observational efforts, a pulsar orbiting a black hole has remained elusive. One possible explanation is the extreme Doppler smearing caused by the pulsar’s orbital motion which changes its apparent spin frequency during an observation. The classical solution to this problem has been to assume a constant acceleration/jerk for the entire observation. However, this assumption breaks down when the observation samples a large fraction of the orbit. This limits the length of search observations, and hence their sensitivity. This provides a strong motivation to develop techniques that can find compact binaries in longer observations. Here we present a GPU-based radio pulsar search pipeline that can perform a coherent search for binary pulsars by directly searching over three or five Keplerian parameters using the template-bank algorithm. We compare the sensitivity obtained from our pipeline with acceleration and jerk search pipelines for simulated pulsar-stellar-mass black hole binaries and observations of PSR J0737-3039A. We also discuss the computational feasibility of our pipeline for untargeted pulsar surveys and targeted searches. Our benchmarks indicate that circular orbit searches for P-BH binaries with spin-period Pspin ≥ 20ms covering the 3-10 Tobs regime are feasible for the High Time Resolution Universe pulsar survey. Additionally, an elliptical orbit search in Globular clusters for Pspin ≥ 20ms pulsars orbiting intermediate-mass black holes in the 5-10 Tobs regime is feasible for observations shorter than 2 hours with an eccentricity limit of 0.1.
|
2022-09-09T04:21:24.412Z
|
252,724,369 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.1108/jbim-02-2022-0105",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Purpose
This paper aims to adopt a resource-based view (RBV) to investigate the link between marketing (MRKT)–supply chain management (SCM) alignment, supply chain resilience (SCR) and firm performance. It aims to cover two gaps in the SCM literature: the missing links between MRKT–SCM alignment and the performance of a firm, mediated by the SCR, and the role of absorptive capacity (AC) in shaping such links.
Design/methodology/approach
After the identification of a key capability in SCM, i.e. firms’ ability to align their’ MRKT–SCM processes and the role of AC, the relationships with performance are empirically tested in a sample of 133 firms in the fast-moving consumer goods industry in Saudi Arabia. The data was analyzed using SPSS 27 through hierarchal multiple regression and the PROCESS macro.
Findings
First, MRKT–SCM alignment capabilities provide a significant direct effect on SCR, and in turn, SCR also had a significant indirect effect on firm performance. Second, there is a significant mediating effect of SCR on the MRKT –SCM alignment and firm performance relationship. Third, a novel finding shows a statistically significant interaction effect and the interaction pattern supported that absorptive capacity would substitute the positive effect of SCR on firm performance, which implies that in the absence of SCR, AC can substitute the role of SCR. Finally, the results suggest a significant moderation and mediation effect for the overall model.
Research limitations/implications
The investigation is based on a self-reported cross-sectional analysis, and it is specific to a single economy. Nonetheless, it suggests a number of interesting implications. Achieving excellence in SCR requires the development of a distinct set of capabilities because the management of core supply chain activities and the alignment of MRKT with the supply chain are not mutually exclusive, rather they are complementary. Contrary to common expectations, an alignment of MRKT–SCM processes leads to improved interfunctional coordination.
Practical implications
In the postCOVID-19 world firms should develop and integrate their AC to capitalize on their MRKT–SCM alignment to pursue better performance. Investment in AC is required to develop, maintain and use it. It can play an important role against uncertainties in the long run.
Originality/value
This paper is unique in that it employs the RBV – to unpack the mechanisms through which MRKT–SCM activities contribute to SCR, and firm performance. It represents a first response to the call for research into the use of such theoretical frameworks which has recently been made in the SCM literature because of the COVID-19 pandemic. To the best of the authors’ knowledge, this paper also offers the first empirical test of how the MRKT–SCM interacts with existing capabilities to create SCR, providing clear guidance on how to exploit its often undervalued potential.
|
2022-12-09T19:01:31.902Z
|
144,769,912 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.1353/LIT.2005.0035",
"MAG": "2026524041",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Wells, Stanley and Lena Cowen Orlin, eds. 2003. Shakespeare: An Oxford Guide. Oxford: Oxford University Press. $24.95 se. 744 pp.Shakespeare: An Oxford Guide is aimed at the undergraduate Shakespeare classroom, probably in English rather than performance or film studies. It is fat and long with material, produced by a stellar group of scholars and teachers. In addition to the usual information about Shakespeare's biography, the theatre, his society, and his audience included in introductions to Collected Works, the first section offers essays on the conventions of playwriting, changing attitudes towards religion, and ideas of order in early modern England. The second section has chapters on each of the major groupings, called "genres" here, of Shakespeare's work, including all the dramatic forms and nondramatic poetry. Each of these essays offers a reading of a single play in light of the survey of the genre which precedes it. The next section introduces twelve critical approaches, again offering a set of sample readings. The last section is concerned with "Shakespeare's Afterlife," and it contains essays on modern theatre, film, translation, and commemoration, among other topics.Few fields in contemporary English studies enjoy the quality and variety of scholarship that Shakespeare studies does. The authors here are among the best-known, and for good reason: their work is exemplary in all facets, from the precision and intelligence of their research to the eloquence and clarity of their exposition. All modern approaches to literary and cultural studies are represented here; no special interests dominate; younger and mature scholars share space in the volume. If one were looking for a summation of the present state of knowledge and interpretation of Shakespeare and his work, written for the undergraduate audience, one need look no further.The editors have done a commendable job of keeping the tone and level of the volume steady, while permitting the distinctive interests and expertise of individual scholars to be heard. In short, this volume is the best of its kind presently available.There are a couple of qualities of the volume, however, which will prevent its adoption in many courses. First, the size is prohibitive: it weighs in at three pounds and paired with the Norton Shakespeare (the cited collected works), the needle on my bathroom scale moves to seven pounds. It's too heavy to have students carry around from class to class with them and too long (744 pages) to get them to digest the material as supplements to the Shakespearean works they are studying. In an ideal world, I would like my students to know this book's contents, and I would like to be able to show them the richness, diversity, and excellence of our knowledge of and pleasure in Shakespeare's works which this volume so wonderfully represents. Contrary to popular belief, however, we English professors have more contact with the real world than we would really like to have, and I would have little success in insisting that my students bring this book to class, and not much more in requiring them to read enough of it to make the purchase worthwhile. And practically speaking, the structure of the courses I teach (twelve week courses, divided chronologically at the year 1601, which effectively creates a generic divide between histories and comedies on the one side, tragedies and romances on the other) means that only a selection of the material would be relevant to my students in any one course, and probably not enough to warrant the expense of the book. There is simply too much material here for this Guide to be ordered for courses, although it will be a welcome addition to the resources available to students in the library.second, problems are inherent in the approach to the construction and transmission of knowledge this volume represents. Most of the content is delivered through telling, rather than showing, despite the prevalence of demonstrations. …
|
2022-07-09T05:05:55.773Z
|
36,584,897 |
{
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"ArXiv": null,
"DOI": "10.1504/IJISTA.2010.030194",
"MAG": "3023593523",
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},
"license": null,
"status": null,
"url": null
}
|
This paper proposes a new method of decentralised robust control for large-scale interconnected uncertain non-linear mechanical systems, by using disturbance observers. Rigorous stability analysis is given for the overall non-linear system. Simulation results on a coupled double pendulum system are presented to confirm the established theoretical results.
|
2022-08-28T13:11:25.698Z
|
25,322,667 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1159/000330060",
"MAG": "2054024230",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://www.karger.com/Article/Pdf/330060"
}
|
variation in adult nervous systems has never been examined from an evo-devo perspective. Only in recent years have significant numbers of neuroscientists begun to ask how adult neural variation can be explained in terms of underlying developmental change. To facilitate the further growth of evo-devo neurobiology, seven speakers gathered for a symposium entitled ‘Developmental Mechanisms of Evolutionary Change in Nervous Systems’ at the Euro-evo-devo meeting in Paris on July 9, 2010. These speakers were Markus Friedrich, Sophie Creuzet, Gerhard Schlosser, Yoshiyuki Yamamoto, Barbara Finlay, Todd Streelman, Loreta Medina, and myself. A subset of us wrote the review papers that are gathered in this special issue of Brain, Behavior and Evolution . The four sets of authors are: (1) Friedrich; (2) Medina, Bupesh, and Abellán; (3) Sylvester, Pottin, and Streelman, and (4) Charvet, Striedter, and Finlay. Instead of summarizing each paper individually, I discuss them in relation to some major themes or elements that can be traced through multiple papers. One common theme in evo-devo work is that conserved similarities must be identified before taxon differences are revealed. Medina et al. provide an excellent example of how gene expression patterns can be used to identify homologous progenitor domains in diverse vertebrates. Their analysis suggests that the mammalian amygdala is generated from as many as seven different progenitor domains and that most of these can be hoAlthough Darwin and other pioneers of evolutionary biology speculated about the relationship between organismal development and evolution, embryology was omitted from the evolutionary synthesis that emerged in the 1940s. This began to change in the 1980s when some of the genes important in Drosophila development, most notably the various hox genes, were found to be broadly conserved across metazoans. Even some functions of these genes appeared to be conserved as vertebrate genes could sometimes substitute for missing fruit fly genes and vice versa. Such a high degree of genomic conservation was surprising given the obvious difference in morphological development between fruit flies and mice. How can conserved genes produce such morphological diversity? From this riddle the field of evolutionary developmental biology (evo-devo) was born. Evo-devo has flourished in the last 15 years and now sports four specialized journals and considerable grant support. The future of evo-devo is currently the subject of debate, with authors discussing, for example, whether the promised synthesis of developmental genetics with evolutionary biology can actually be completed. With regard to neuroscience, however, the future of evo-devo is bright for evo-devo neurobiology is still young. Despite important early work on the evolution and development of eyes and the evolutionary inversion of the nervous system’s dorsoventral position within the embryo (i.e. dorsal in vertebrates and ventral in arthropods), most of the Published online: August 23, 2011
|
2022-08-28T00:40:21.346Z
|
5,913,610 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1080/02681102.2015.1121857",
"MAG": "2462274527",
"PubMedCentral": null
},
"license": "CCBY",
"status": "HYBRID",
"url": "https://www.tandfonline.com/doi/pdf/10.1080/02681102.2015.1121857?needAccess=true"
}
|
This research joins the growing body of literature that advocates for the use of information and communication technology (ICT) in local governance more particularly in public financial management. Using a case study in Bohol, a province in the Philippines, this paper discusses the impact of ICT on local revenue generation by analyzing both quantitative and qualitative data from 15 municipalities which used e-taxation. This paper argues that the use of ICT can make possible more transparent and accountable revenue generation systems to benefit both government and taxpayers. However, these results are differentiated depending on the level of political leadership, the nature of articulation of the demand for ICT use, the ratio of benefit against cost, and the availability of technical skills and resources at the sub-national level. It is within this context that an eco-system analysis is argued to be useful in analyzing how ICT can be adopted, scaled, and used by sub-national governments to achieve better governance.
|
2022-12-07T22:41:49.662Z
|
190,544,978 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.22201/ENALLT.01852647P.1997.25.333",
"MAG": "750793325",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This experimental research on the usage of the sentence combining technique in the L2 writing process tries to optimize the writing of texts among Spanish speakers who learn or acquiere the English language in the classroom. For more than a year; the same was exposed to the internalization of grammar elements in contexts (Direccion de Investigacion de la Universidad de Chile de Concepcion; code 94.65.17-1; CHILE). To achieve the general objective; a Control Group and an Experimental Group were selected. The first one developed a traditional Writing Program to write English texts and the second one developed integrated strategies when exposed to different computing sentence combining exercises according to a Pilot Plan. This Plan was designed to develop reading; speaking and writing competences. The research design consisted of a Prestest/ Development of integrated strategies/Postest. The independent variable was that of combining sentence and the dependent variables were the following: text organization; lexical coherence; cohesion; logic progression of ideas and punctuation. These variables helped to achieve the results and to accept the hypothesis given in the study. Statistical means applied to the information obtained in the written texts showed that the experimental group results were higher than those of the control group and the students could write better qualified articles.
|
2022-12-11T03:34:20.037Z
|
93,165,520 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4028/www.scientific.net/AMR.938.292",
"MAG": "1987176491",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Novel nanogold doped TiO2 nanoparticles are found to be highly efficient for the photocatalytic degradation of organic pollutants. TiO2 nanoparticles were synthesized from titanium (IV) isopropoxide through hydrothermal route. Gold nanoparticles were prepared by chemical reduction and stabilization employing D-glucosamine, and were doped in TiO2 nanoparticles. The analysis revealed that the diameter of gold nanoparticles used for doping is around 5 nm. Undoped and gold doped samples were characterized by X-ray diffraction (XRD), Raman spectroscopy, UV-Vis diffuse reflectance spectra (DRS) and field emission scanning electron microscopy (SEM). DRS study showed that nanogold doping in titania nanoparticles induces a shift of absorption edge to the visible range and reduces the band gap. Complementing our earlier finding that noble metal doping in titania nanoparticles enable photocatalytic activity in the visible region, it is showed that gold doping enhances photocatalytic activity of the titania nanoparticles. This was confirmed by the degradation of the dye methylene blue repeatedly using gold doped nanoparticles under direct sunlight. Further, the nanoparticles were used to study the degradation of the persistent organic pollutant, β endosulfan, and near complete degradation were observed in an hour. Regenerated nanoparticles were found effective for the degradation of the pesticide for more than three cycles.
|
2022-12-19T07:11:53.524Z
|
28,703,469 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1086/664685",
"MAG": "1990113261",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This article examines the diffusion of protest tactics among social movement organizations (SMOs) through their collaboration in protest groups. Using a longitudinal data set of SMO protest activity between 1960 and 1995, the authors adapt novel methods for dealing with two forms of selection and measurement bias in network analysis: (i) the mechanism that renders some SMOs more likely to select into collaboration and (ii) the notion that diffusion is an artifact of homophily or indirect learning rather than influence. The authors find that collaboration is an important channel of tactical diffusion and that SMOs with broader tactical repertoires adopt more tactics via their collaboration with other SMOs, but only up to a point. Engaging in more collaboration also makes SMOs more active transmitters and adopters of new tactics. Finally, initial overlap in respective tactical repertoires facilitates the diffusion of tactics among collaborating SMOs.
|
2022-12-28T17:59:21.399Z
|
33,344,473 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4236/CS.2016.74029",
"MAG": "2343270107",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The NoC consists of processing element (PE), network interface (NI) and router. This paper proposes a hybrid scheme for Netwok of Chip (NoC), which aims at obtaining low latency and low power consumption by concerning wired and wireless links between routers. The main objective of this paper is to reduce the latency and power consumption of the network on chip architecture using wireless link between routers. In this paper, the power consumption is reduced by designing a low power router and latency is reduced by implementing a on-chip wireless communication as express links for transferring data from one subnet routers to another subnet routers. The average packet latency and normalized power consumption of proposed hybrid NoC router are analyzed for synthetic traffic loads as shuffle traffic, bitcomp traffic, transpose traffic and bitrev traffic. The proposed hybrid NoC router reduces the normalized power over the wired NoC by 12.18% in consumer traffic, 12.80% in AutoIndust traffic and 12.5% in MPEG2 traffic. The performance is also analyzed with real time traffic environments using Network simulator 2 tool.
|
2022-01-27T12:30:46.262Z
|
68,305,460 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1017/CBO9780511544699.023",
"MAG": "237591838",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Introduction Crucial advances in our understanding of atherogenesis have been achieved during the past two decades. The historical hypothesis of pathogenesis (‘lipid accumulation’) has evolved to integrate several pathogenic mechanisms contributing to the initiation and evolution of atherogenesis. Vascular inflammation and apoptosis may play pivotal roles in its progression and onset. Endothelial dysfunction is considered to be one of the earliest events in atherogenesis. This chapter will discuss emerging concepts in the pathogenesis of, and therapeutic approaches to, atherosclerosis. Some novel risk factors, including impaired fasting glucose, triglycerides and triglyceride-rich lipoprotein remnants, lipoprotein (a), homocysteine, and high-sensitivity C-reactive protein, might contribute to an increased risk of atherosclerosis (Fruchart et al . 2004). Moreover, hypercholesterolaemia and hypertension have synergistic deleterious effects on coronary endothelial function (Rodriguez-Porcel et al . 2003). The pathogenesis of atherosclerosis has been related also to infiltration of immune cells, which are involved in systemic and local, innate as well as adaptive, immune responses (Zhou and Hansson 2004). As some inflammatory and autoimmune diseases could be treated by immunologically based therapy, it is of particular interest to consider whether such principles could also be applied to prevent or treat atherosclerosis. Atherosclerosis is ultimately responsible for myocardial infarction, peripheral arterial disease and ischaemic stroke, and is characterised by a long lag-time between onset and clinical manifestation. The prodromal stages of human atherosclerotic lesions are already formed during fetal development (Napoli et al . 1997a, 1999a, Palinski and Napoli 2002a). Intimal thickening is also observed in fetal coronary arteries (Ikari et al . 1999).
|
2022-02-11T12:17:18.041Z
|
15,846,136 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.21437/icslp.2000-882",
"MAG": "142068109",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Approximating vocal tract by a series of acoustical tubes, reflection coefficients between the tubes are essential parameters for vocal tract area estimation. These parameters have been obtained through PARCOR analysis, with some devices to eliminate undesirable effects of fundamental period and radiation between lips. In this paper, vocal tract ratio estimation method is proposed using temporally and spectrally smoothed spectral envelope obtained by STRAIGHT speech analysis and synthesis method. The spectrum is transformed PARCOR coefficients, which are used to estimate the vocal area ratios. As a result, the proposed method can make a stable estimate of vocal tract area ratios in both temporal and spectral.
|
2022-09-30T17:22:59.031Z
|
246,189,300 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.52041/srap.19403",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://doi.org/10.52041/srap.19403"
}
|
Bringing real problems into curriculum is not an easy job but assessing such student work is even harder, especially when universities are run like businesses where academics are given only limited hours to assess student work. The literature documents that authentic problems are more engaging for students and thus there is no argument against having such problems in the curriculum. However, the literature also shows that assessment of such student work is costly in terms of time. We have developed marking rubrics to standardise marking such assessment tasks, as well as providing some guidance to students on what is expected of them. A mentoring model, putting ourselves (as lecturers) as part of the students’ work, but letting students make decisions and solve problems, has been at the heart of our rubric development. We will share our experience of dealing with the increased assessment workload arising from incorporating work-integrated learning into a capstone unit for an undergraduate major in statistics by providing examples of how real projects that are beneficial to students and industry can be assessed in a way that is time efficient for academics. The example rubrics can be adopted, further developed or modified by colleagues who are hesitant to move into this direction. Our experience shows that assessments of real projects can be completed more efficiently by utilising such marking rubrics. Students seem satisfied with the mentoring and guidance they receive, and with the feedback they get for their projects. Given that such marking rubrics have not been widely developed or used in statistics education generally, nor specifically for real projects, we believe that our examples will be helpful for statistics educators generally.
|
2022-01-28T02:56:45.811Z
|
113,321,463 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2172/1160201",
"MAG": "2293105450",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://www.pnnl.gov/main/publications/external/technical_reports/PNNL-23386.pdf"
}
|
This document reports on a series of tests conducted to assess the proposed air sampling locations for the Hanford Tank Waste Treatment and Immobilization Plant (WTP) Group 1-2A exhaust stacks with respect to the applicable criteria regarding the placement of an air sampling probe. The LV-C2, LV-S2, and LV-S3 exhaust stacks were tested together as a group (Test Group 1-2A). This report only covers the results of LV-S2 and LV-S3; LV-C2 will be reported on separately. Federal regulations1 require that a sampling probe be located in the exhaust stack according to the criteria established by the American National Standards Institute/Health Physics Society (ANSI/HPS) N13.1-1999, Sampling and Monitoring Releases of Airborne Radioactive Substances from the Stack and Ducts of Nuclear Facilities. 2 These criteria address the capability of the sampling probe to extract a sample that represents the effluent stream.
|
2022-02-10T02:33:04.734Z
|
17,496,819 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1145/1667146.1667163",
"MAG": "2044018438",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Surface simplification aims to reduce the complexity of a 3D model while maintaining a good approximation to the original model. In this work, we propose a novel combination of geometry images and content-aware image resizing to achieve efficient surface simplification. There are two main advantages to simplify surface based on geometry images. First, it is relatively simple to simplify the surface in the parameterized 2D space because the features of a 3D surface can be easily represented by the gradient energy. Second, the regularity and features on 3D surface can also be preserved without additional effort. The proposed retargeting algorithm performs well both on real images and 3D surface simplification.
|
2022-07-26T13:20:47.313Z
|
98,045,628 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/15421407308084231",
"MAG": "2072267276",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
A theory is developed of the optical properties of a non-absorbing compensated cholesteric liquid crystal. It is shown that the Mauguin—de Vries equation fails when the pitch becomes very large. Th...
|
2022-09-10T21:03:38.889Z
|
6,138,543 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1476-5381.1982.tb09178.x",
"MAG": "2062249630",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc2071531?pdf=render"
}
|
1 Short circuit current (SCC), transepithelial conductance and ion fluxes were measured across the isolated descending colon of the rat in response to bradykinin or kallidin. 2 Kinins added to the serosal bath caused immediate increases in SCC but were ineffective when added to the mucosal bath. Increases in SCC were accompanied by significant increases in transepithelial conductance. Threshold kinin concentration was 0.5 nm and maximal increases were seen at 50–100 nm. 3 A rat glandular kallikrein (7 nm) or mellitin (2 μm) also increased SCC if added to the serosal bath. 4 Responses to kinins were unaffected by mucosal amiloride (100 μm) but attenuated or blocked by serosal frusemide (100 μm), indomethacin (1 μm) or mepacrine (50 μm). 5 Replacement of chloride ion in the serosal bath by gluconate and sulphate ions abolished responses to kinins which reappeared after chloride re‐addition. 6 Measurement of 36Cl, 22Na and 86Rb fluxes across the tissue showed that the kinin‐induced increase in SCC resulted principally from increased net chloride secretion. Effects upon 22Na or 86Rb flux were minimal and made no contribution to the current responses observed in this tissue. 7 The results prove that kinins stimulate net chloride secretion in the rat colon, most probably via a prostaglandin‐dependent pathway.
|
2022-12-11T07:35:55.792Z
|
239,598,130 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.34071/jmp.2018.6.2",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Objectives: To evaluate the survival outcome, patterns of failure, and complications in patients treated with postoperative chemoradiation therapy in stages II-III of distal gastric cancer.
Materials & methods: Prospective study on 58 patients with stages II-III gastric adenocarcinoma, underwent distal gastrectomy and D1 or D2 dissection, completed post operative chemoradiation therapy with capecitabine and 4-6 cycles with EOX regimen at Oncology center of Hue central hospital from 01/2013 to 12/2015.
Results: Mean age was 55.16 ± 9.1, male/female ratio: 3/1, recurrence was common in the first year after treatment (62.5%), the average time of recurrence and metastasis were 13.50 ± 7.29 months and 18.75 ± 8.97 months, respectively. The mean overall survival was 41.21 ± 21.06 months. The mean disease free survival was 36.22 ± 22.64 months. The mean overall survival: stage II was 41.88 ± 20.78 months; stage III was 39.59 ± 22.27. The mean overall survival for extention of primary tumors: T3 was 40.79 ± 19.61 months; T4 was 41.33 ± 24.80 months. The mean overall survival for extensive of lymph nodes: N (-) was 41.16 ± 20.51 months, N (+) was 41.26 ± 22.06 months. Toxicity levels recorded as follow: leukopenia was mainly on grade 1 and 2 (33.6%), neutropenia was mostly on grade 1 and 2 (26.8%), as well as thrombocytopenia (8.6%); hemoglobin decrease was on grade 1 and 2 in most cases (41.4%); toxicity symptoms on digestive system like nausea-vomitting, diarrhea was mainly on grade 1 and 2.
Conclusion: Postoperative chemoradiation therapy helps to improve local and regional recurrence in locally advanced gastric cancer with acceptable toxicities.
Key words: Distal gastric adenocarcinoma, postoperative chemoradiation therapy
|
2022-12-14T01:32:41.326Z
|
33,648,194 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/J.1574-6968.1994.TB07079.X",
"MAG": "2068456626",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Bleomycin-producing Streptomyces verticillus ATCC15003 possesses a bleomycin acetyltransferase which inactivates the drug in the presence of acetyl coenzyme A. The site of acylation in enzymically prepared acetylbleomycin A2 was determined by nuclear magnetic resonance analysis; the primary amino group of the beta-aminoalanine moiety of bleomycin was acetylated Acetylbleomycin A2 had no detectable antibacterial activity and did not induce in vitro DNA degradation.
|
2022-12-18T08:54:31.147Z
|
51,939,822 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/imj.14069",
"MAG": "2885809105",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "http://minerva-access.unimelb.edu.au/bitstreams/3d66ecc9-db69-5523-ab6c-7cce3c92c541/download"
}
|
Endovascular thrombectomy (EVT) for management of large vessel occlusion (LVO) acute ischaemic stroke is now current best practice.
|
2022-12-20T11:13:19.801Z
|
123,142,386 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S0022112093003192",
"MAG": "2120429925",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We discuss a series of numerical experiments on the dispersion of neutrally buoyant particles in two-dimensional turbulent flows. The topology of two-dimensional turbulence is parametrized in terms of the relative dominance of deformation or rotation; this leads to a segmentation of the turbulent field into hyperbolic and elliptic domains. We show that some of the characteristic structural domains of two-dimensional turbulent flows, namely coherent structures and circulation cells, generate particle traps and peculiar accelerations which induce several complex properties of the particle dispersion processes at intermediate times. In general, passive particles are progressively pushed from the coherent structures and tend to concentrate in highly hyperbolic regions in the proximity of the isolines of zero vorticity. For large dispersion times, the background turbulent field is a privileged domain of particle richness; there is however a permanent particle exchange between the background field and the energetic circulation cells which surround the coherent structures. At intermediate times, an anomalous dispersion regime may appear, depending upon the relative weight of the different topological domains active in two-dimensional turbulence. The use of appropriate conditional averages allows the basic topology of two-dimensional turbulence to be characterized from a Lagrangian point of view. In particular, an intermediate $t^{\frac{5}{4}}$ anomalous dispersion law is shown to be associated with the action of hyperbolic regions where deformation dominates rotation; the motion of the advected particles in strongly elliptic regions where rotation dominates over deformation is shown to be associated with a $tt^{\frac{5}{3}}$ dispersion law. Because neutral particles concentrate on average in hyperbolic regions, the $t^{\frac{5}{4}}$ dispersion law is quite robust and it can be observed under very general circumstances.
|
2022-12-31T19:13:23.569Z
|
150,135,446 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1097/01.JU.0000554932.80711.5d",
"MAG": "2940873187",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
INTRODUCTION AND OBJECTIVES: This study evaluates oral agents used to visualize ureteral jets at the time of intraoperative cystoscopy. Agents examined by the study are oral pyridium and vitamin B riboflavin. The study looks to determine if administration of a standard oral dose of vitamin B riboflavin is a comparable oral agent to pyridium for evaluating patency of ureteral jets at the time of intraoperative cystoscopy. METHODS: A 3 arm double-blinded, randomized controlled pilot study was performed. Group 1 was administered pyridium, Group 2 was administered vitamin B riboflavin, and group 3 was administered thiamine as a placebo. The surgeons and patients were both blinded to the treatment. The agents were administered to the subjects on the morning of surgery 1 hour (+/- 15 minutes) prior to the procedure. A data sheet with a urine color scale was used intraoperatively as a grading system by the surgeons to grade the color of the urine jet and to evaluate the strength of the urine jet. RESULTS: The Cochran-Mantel-Haenszel for ordinal outcomes was used to compute the appropriate Chi-square test for equivalence between color intensity of the three groups. Preliminary results from the first 10 patients in the study have found comparable results for urine color intensity for both vitamin B riboflavin and pyridium and overall the results showed that both agents produced a strong urine jet with moderate color intensity in 75% of cases for vitamin B riboflavin and 80% of cases for pyridium as evaluated by the surgeons at the time of cystoscopy. Renal function influenced the results. Patients with creatinine levels greater than 0.5 were found to have bright colored urine jets 80% of the time based on surgeon evaluation with the urine color grading scale while patients with creatinine levels less than 0.5 were found to have light/no colored urine 15% of the time. CONCLUSIONS: Vitamin B riboflavin is an appropriate comparable oral agent to pyridium for producing urine staining and evaluating the patency of ureteral jets at the time of intraoperative cystoscopy. Renal function can impact the evaluation of urine color. Patients with lower creatinine levels and higher functioning kidneys may clear the oral agents more quickly in the urine which may in some cases lessen the intensity of the urine jet and cause the urine to have a lighter color. However, patients with lower functioning kidneys as indicated by higher creatinine levels may have more concentrated urine which may cause urine jets to have brighter colored urine in some cases. One must account for renal function when using oral agents for evaluation of ureteral patency. Source of Funding: None
|
2022-01-27T13:02:09.524Z
|
11,144,280 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3769/radioisotopes.34.3_125",
"MAG": "2064893997",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://www.jstage.jst.go.jp/article/radioisotopes1952/34/3/34_3_125/_pdf"
}
|
One-pass method with a piecewise cubic polynomial was used as a smoothing technique in gamma ray spectrum analysis. By this method, smoothed results of spectrum region is represented to several divided intervals each of which are fitted with a cubic polynomial calculated by least square technique, respectively. From the smoothing procedure of simulated photoelectric peaks and actual gamma ray spectra, following results were obtained. Photoelectric peaks which had more than 10 channels of FWHM (full width at half maximum) were fitted correctly and low count spectra of about 100 counts per channel could also be fitted smoothly. These smooth results can not easily be obtained by Savitzky's convolution technique. In conclusion, this one-pass method was found to be effective for gamma ray spectra, especially for photoelectric peaks of large FWHM and Compton region.
|
2022-02-13T05:35:25.660Z
|
245,184,170 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.36869/wjsb.v12i2.239",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
This study aimed to describe the activities of Tuju-Tuju Port in the period of 1990 to 2015. The Tuju-Tuju Port in Bone Regency is a port that transports various commodities produced from several areas in South Sulawesi to other areas, especially to East Nusa Tenggara and its surroundings. The result study showed the activities in Tuju-Tuju Port that the ships going in and out of Tuju-Tuju Port were crowded everyday. Even though the port condition is not yet fully adequate, the loading and loading of goods still continues. The method used was the historical method with analytical descriptive consisting heuristics, source criticism, interpretation, and writing. The Tuju-Tuju Port in Bone Regency is a companion port from other ports in Bone Regency. The Tuju-Tuju Port can affect the local economy, such as increasing regional income and opening up job opportunities for the productive ages. The Tuju-Tuju Port over time has also developed the existing loading and unloading system with simple facilities and infrastructure in Tuju-Tuju Port. Daily activities continue, so the ships that are leaning on the pier and waiting for departure scheduled are crowded adorning the harbor.
|
2022-04-08T01:02:26.229Z
|
78,910,792 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3168/JDS.S0022-0302(81)82734-8",
"MAG": "2160592231",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Concentrations of thyroxine in blood plasma were measured by radioimmunoassay in 32 dairy cows postpartum and during estrous cycles. Mean concentrations of thyroxine declined from 1 to 2 days postpartum to 5 or 6 days postpartum. Concentrations of thyroxine remained low at 7 to 10 days postpartum and during the first estrous cycle. During subsequent estrous cycles concentrations of thyroxine were elevated to those 1 or 2 days postpartum.
|
2022-09-11T07:03:17.222Z
|
234,697,763 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.21203/rs.3.rs-28198/v1",
"MAG": "3117281866",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GREEN",
"url": "https://www.researchsquare.com/article/rs-28198/latest.pdf"
}
|
The novel coronavirus (COVID-19) pandemic started in December 2019 in Wuhan (Hubei, China) and spread rapidly; therefore, it is essential to detect the disease at an early stage and immediately isolate the infected patients [1]. The most common symptoms of COVID-19 infection include fever, asthenia, cough and dyspnea [2]. However, some patients are asymptomatic from the respiratory symptoms, and may only present abdominal manifestations as an initial finding, what creates a diagnostic challenge.We describe two cases with diagnostic confirmations of COVID-19 who showed up at the Emergency Department with abdominal symptoms before presenting respiratory manifestations, and who had their initial suspicion based on the findings of the thoracoabdominal transition, demonstrating the importance of an adequate assessment of the lung base images.
|
2022-10-29T14:07:36.408Z
|
119,897,728 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1103/PHYSREVB.1.274",
"MAG": "1988975790",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Measurements of the lattice parameter, electronic specific heat, magnetic susceptibility, and Debye temperature are presented in the Ni-Ir alloy system from 0 to 100 at.% Ir. This system forms an uninterrupted series of solid solutions over the entire concentration range. No ordering nor decomposition could be observed after annealing for several days at temperatures between 500 and 1100\ifmmode^\circ\else\textdegree\fi{}C. The system develops a sharp peak in the electronic specific heat versus concentration at 85 at.% Ni, a concentration slightly higher than the critical concentration determined magnetically (81 at.% Ni). A weak anomaly was found also in the ${T}^{3}$ term of the low-temperature specific heat around the same concentration. Generally, no lowtemperature anomaly, such as was predicted by the early paramagnon theories, was detected down to 1.5\ifmmode^\circ\else\textdegree\fi{}K. The susceptibility was measured on the paramagnetic side only up to 79 at.% Ni, where a spontaneous moment develops at low temperature.
|
2022-10-02T17:00:08.679Z
|
195,532,044 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.24833/2410-2423-2018-4-16-85-92",
"MAG": "2948477274",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The analysis of existing studies at the scope of cognitive linguistics and the methodology of teaching foreign languages has shown a significant degree of elaboration of this topic and allows the authors of the article to talk about the great potential of using the achievements of cognitive linguistics in the practice of teaching a foreign language. The article tracks the causes of the increased interest in recent cognitive language studies and approaches to the study of cognitive linguistics. The authors point out the special role of cognitive linguistics as a new scientific paradigm in the practice of teaching foreign languages. The general modern tendencies typical for the given scientific direction are commented with reference to the teaching of English in a law school. The examples of the difference in the compatibility of linguistic units in Russian and English show the need for developing students’ conceptual analysis skill. The authors explain how the achievements of cognitive linguistics can be used in teaching a foreign language, including English, to Russian-speaking students. The proposed cognitive-linguistic methods, study of the external frame structure of the word, the conceptual analysis and the formation of interpreting skills of foreign concepts, according to the authors, can significantly improve the effectiveness of teaching a foreign language, including English, at various levels of education and in various higher and secondary educational institutions.
|
2022-02-08T07:47:43.452Z
|
225,165,010 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.24256/KHARAJ.V2I2.1530",
"MAG": "3086709103",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The purpose of this study is to determine capital gain in the Islamic economy. This research is a qualitative study. In Islamic economics, investment is a muamalah activity that is highly recommended, because investment funds are needed to be productive and also bring benefits to others. The Qur'an strictly forbids hoarding (ikhtinaz) ownership activities. An investor's profit in the stock game is obtained through capital gain by selling shares when the selling price is higher than the price previously bought. The results show that capital gain in Islamic economics are permissible as long as they are not sourced from al Gharar. If sourced al Gharar is forbidden because it contains maysir. Capital gain are also forbidden if a percentage of profits has been determined for each period
|
2022-04-30T12:21:04.592Z
|
119,882,288 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/09205071.2014.990112",
"MAG": "1995247062",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Mutual coupling performance of the microstrip circular polarization (CP) antenna array is analyzed in this study. Compared with the single antenna application, in the antenna array, the S11, the radiation pattern, and the axial ratio will all be changed due to the mutual coupling and the axial ratio will be more sensitive. To further prove the concept and performance effect, a model of the microstrip antenna array is developed and analyzed in theory. The simulation and measurement results demonstrate that the relative position of antennas in the array exert different effect on the performances of the antenna. Thus, the study provides some very useful results of the CP antenna array.
|
2022-06-06T19:52:41.216Z
|
243,976,941 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/13102818.2021.1985612",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.tandfonline.com/doi/pdf/10.1080/13102818.2021.1985612?needAccess=true"
}
|
Abstract Horizontal gene transfer (HGT) is recognized as a major driver of adaptive evolution in prokaryotes. However, HGT seems impossible in eukaryotes, particularly as recipients; therefore, debate rages regarding whether HGT takes place in eukaryotes, in addition to its potential mechanism or frequency. Bacterial symbionts, whether mutualistic, commensalistic or parasitic, have been considered potential donors for eukaryotes. In this study, we used a bacterial–plant interaction system to systematically investigate HGT in plants. In total, 373 HGT events were identified based on a pipeline procedure, and 90 HGTs were confirmed as true events, with 27.27%–86.5% sequence similarities. We propose that both ancient transfer and recent specific transfer (e.g. Agrobacteria) occurred in the course of plant evolution. The most enriched functional categories of the HGTs were metabolism processes of amino acids, cofactors and vitamins, and carbohydrates, and genetic information processing. Donor bacterial genera were significantly enriched in plant-associated bacterial groups, which indicated that plant–bacterial interaction facilitates HGT in plants. No clade- or species-specific HGTs were detected, and all occurred anciently during the origin of angiosperm plants. In addition, we identified 309 ‘one-species’ HGT events, and as expected, all the events could be accounted for as sequence errors or inaccurate annotations.
|
2022-12-02T11:46:53.535Z
|
210,956,072 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4025/actascitechnol.v42i1.45181",
"MAG": "2998910388",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/download/45181/751375149033"
}
|
Considering the importance of technical accessibility parameters to the adequacy of urban areas for all people, this study aimed to develop a quantification method of pedestrian accessibility based on the technical standardization. The Accessibility of Walkable Spaces index (AWS) is composed of seven measurable indicators according to standards of accessibility, ranging from 0 (Inaccessibility) to 1 (Accessibility). After an audit of 570 sidewalk stretches in São Tomé, State of Paraná, Brazil, the Inaccessible situation was verified as the most recurrent (60.3% of the sidewalk stretches). The best conditions were found in the more consolidated urban central area, as demonstrated by the KruskalWallis and Dunn tests (p < 0.05). The method showed adequate applicability. So, municipalities can use AWS index as a useful planning tool to prioritize interventions and provide inclusive and more sustainable environments to its citizens.
|
2022-12-11T01:43:59.990Z
|
233,370,405 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/ijnp/pyab020",
"MAG": null,
"PubMedCentral": "8378078"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://academic.oup.com/ijnp/article-pdf/24/8/601/39820493/pyab020.pdf"
}
|
Abstract Background Negative symptoms are a core aspect of psychopathology in schizophrenia. Currently available pharmacological agents have proven minimally efficacious for remediating negative symptoms. A promising treatment avenue is the intranasal administration of the neuropeptide oxytocin. However, there have been inconsistencies in effects of oxytocin on negative symptoms throughout the literature, and factors leading to inconsistent effects are unclear. Methods We conducted a systematic review and meta-analysis of randomized clinical trials to compare the effectiveness of oxytocin with placebo for the treatment of negative symptoms and determine moderators of treatment effect. Random effects meta-analyses and dose-response meta-analysis were performed on mean changes in negative symptoms. Results In an initial analysis of all 9 identified randomized clinical trials, intranasal oxytocin showed no significant effect on negative symptoms. For higher doses (>40–80 IU), a beneficial effect on negative symptoms was found with a moderate effect size, but this effect disappeared after exclusion of 1 outlier study. The dose-response meta-analysis predicted that higher doses of oxytocin may be more efficacious for negative symptoms. For positive symptoms, no beneficial effect of oxytocin was found in the main meta-analysis, but the dose-response meta-analysis suggested a potential advantage of higher doses. Conclusions The present results show no consistent beneficial effect of intranasal oxytocin for the treatment of negative and positive symptoms. The dose-response meta-analysis does not allow drawing any firm conclusions but suggests that high doses of intranasal oxytocin may be more efficacious. If future studies are conducted, an effort to reach adequate CNS concentrations for a sufficient duration is required.
|
2022-12-29T18:18:51.880Z
|
53,509,414 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1051/RADIOPRO/20116743S",
"MAG": "2038955522",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In January 2009, the IAEA EMRAS II (Environmental Modelling for Radiation Safety II) program was launched. The goal of the program is to develop, compare and test models for the assessment of radiological impacts to the public and the environment due to radionuclides being released or already existing in the environment; to help countries build and harmonize their capabilities; and to model the movement of radionuclides in the environment. Within EMRAS II, nine working groups are active; this paper will focus on the activities of Working Group 1: Reference Methodologies for Controlling Discharges of Routine Releases. Within this working group environmental transfer and dose assessment models are tested under different scenarios by participating countries and the results compared. This process allows each participating country to identify characteristics of their models that need to be refined. The goal of this working group is to identify reference methodologies for the assessment of exposures to the public due to routine discharges of radionuclides to the terrestrial and aquatic environments. Several different models are being applied to estimate the transfer of radionuclides in the environment for various scenarios. The first phase of the project involves a scenario of nuclear power reactor with a coastal location which routinely (continuously) discharges 60 Co, 85 Kr, 131 I, and 137 Cs to the atmosphere and 60 Co, 137 Cs, and 90 Sr to the marine environment. In this scenario many of the parameters and characteristics of the representative group were given to the modellers and cannot be altered. Various models have been used by the different participants in this inter-comparison (PC-CREAM, CROM, IMPACT, CLRP POSEIDON, SYMBIOSE and others). This first scenario is to enable a comparison of the radionuclide transport and dose modelling. These scenarios will facilitate the development of reference methodologies for controlled discharges.
|
2022-03-11T08:50:27.350Z
|
71,266,592 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1921/095182410X535935",
"MAG": "2007892124",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Worldwide the numbers of older people in the population are increasing. Simultaneously the need for treatment programmes increases as more alcohol dependent people are growing into old age. Literature reviews revealed that groupwork programmes offered to older persons are exclusively problem-centred, while strengths- based scholars suggest that following a strengths perspective may be more effective. The majority of studies tend to evaluate the outcomes of treatment programmes quantitatively. It was also found that South Africa, which adopted a developmental approach towards social welfare, lacks groupwork programmes specifi cally designed for alcohol dependent older persons. This article reports on the outcomes of a strengths- based groupwork programme for alcohol dependent older persons. The programme is unique in the sense that it is based on a strengths perspective; it is reconcilable with South Africa's welfare approach; and follows a mixed methods research approach in order to evaluate the programme holistically. Eight respondents were randomly selected. The results, collected with a group administered questionnaire, show that the respondents' psychosocial functioning improved, in that: their repertoire of strengths increased and they have achieved, or are on a path towards, ego integrity. This programme is considered to be complementary to current treatment programmes.
|
2022-09-10T10:55:52.891Z
|
49,398,585 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4236/JEP.2011.26095",
"MAG": "2032715799",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Seasonal variation of antimony was studied in order to characterize its distribution in estuarine water, pore water, sediment, and digenetic behavior in the Sundarbans mangrove ecosystem. The mean concentration of dissolved inorganic Sb ranged between 230.8 and 303.1 ng L–1 over the period of study with a minimum during the post-monsoon closely associated with spring diatom bloom. Molecular diffusion flux of Sb was found greater than its value advected and deposited on sediment-water interface and there was significant remobilization of Sb in the Sundarbans mangrove ecosystem.
|
2022-09-30T00:51:54.697Z
|
27,389,783 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/IEDM.2001.979641",
"MAG": "2538188273",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this paper we present for the first time mid-gap CoSi/sub 2/ metal gates obtained by total gate silicidation meaning that the silicidation process decay itself once the reaction front arrives down to the gate oxide and no more polysilicon is left. Metal gate are required for FDSOI but they may also be useful for low gate-resistance bulk RF devices. For simplicity, we have investigated totally silicided gates within a 0.1 /spl mu/m CMOS bulk technology. In the next step, CoSi/sub 2/ metal gates were processed after the poly CMP step (first CMP in damascene process) in order to protect source and drain from deep silicidation. Low gate resistivity transistors were obtained, exhibiting good performances without degradation in gate leakage, subthreshold slope nor in drive and off currents compared with reference poly-silicon gate transistors.
|
2022-12-16T11:39:02.945Z
|
22,935,752 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1128/AEM.71.6.3060-3067.2005",
"MAG": "2095969179",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT Lactobacillus rhamnosus GG is an industrially significant probiotic strain with proven health benefits. In this study, the effect of glucose on L. rhamnosus GG survival was analyzed in simulated gastric juice at pH 2.0. It was found that the presence of 19.4 mM glucose resulted in up to 6-log10-enhanced survival following 90 min of exposure. Further work with dilute HCl confirmed that glucose was the sole component responsible. Comparative analysis with other Lactobacillus strains revealed that enhanced survival was apparent in all strains, but at different pH values. The presence of glucose at concentrations from 1 to 19.4 mM enhanced L. rhamnosus GG survival from 6.4 to 8 log10 CFU ml−1 in simulated gastric juice. The mechanisms behind the protective effect of glucose were investigated. Addition of N′,N′-dicyclohexylcarbodiimide to simulated gastric juice caused survival to collapse, which was indicative of a prominent role in inhibition of F0F1-ATPase. Further work with neomycin-resistant mutants that exhibited 38% to 48% of the F0F1-ATPase activity of the parent confirmed this, as the survival in the presence of glucose of these mutants decreased 3 × 106-fold compared with the survival of the wild type (which had a viability of 8.02 log10 CFU ml−1). L. rhamnosus GG survival in acidic conditions occurred only in the presence of sugars that it could metabolize efficiently. To confirm the involvement of glycolysis in the glucose effect, iodoacetic acid was used to inhibit glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity. The reduction in GAPDH activity caused survival to decrease by 8.30 log10 CFU ml−1 in the presence of glucose. The data indicate that glucose provides ATP to F0F1-ATPase via glycolysis, enabling proton exclusion and thereby enhancing survival during gastric transit.
|
2022-12-30T18:25:56.312Z
|