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220,965,210 |
{
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"DOI": "10.13345/j.cjb.190500",
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|
Cordycepin as the main active ingredient of Cordyceps militaris, a traditional medicinal fungus in China, has many physiological functions such as anti-cancer, anti-tumor and anti-virus activity. The most potential route for effective cordycepin production has been considered as liquid fermentation of C. militaris though with low productivity at present. Thus, it is urgent to apply both process engineering strategy and metabolic engineering strategy to enhance the productivity of cordycepin. In this review, the effects of medium components (i.e. the carbon/nitrogen source, precursor substances and metal ions) and operation factors (i.e. pH, dissolved oxygen and light) on cordycepin biosynthesis in liquid fermentation system are summarized. Besides, separation of cordycepin, the gene cluster involved and predicted biosynthesis pathways of cordycepin are also discussed, providing possible solutions of finally realizing efficient production of cordycepin.
|
2022-01-27T02:39:39.025Z
|
19,432,718 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1108/02640470910998588",
"MAG": "2006988662",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Purpose – The purpose of this paper is to advise the Library sector about the existence of a new approach to internal communications, in the form of an intranet which delivers “fresh news daily”, similar in format to a major online newspaper.Design/methodology/approach – In 2007, and prior to the launch of its redeveloped intranet, the State Library of Victoria revolutionised its internal communications with the introduction of The Fridge – a new, online, daily news service. A small icon – in the shape of a fridge – was posted on the desktop of every Library staff member.Findings – Today, The Fridge has become a widely used and highly trusted Library tool. It has demonstrated an enhanced commitment to “real‐time” employee communication through the ability to deliver fresh news and important information daily. It has demonstrably increased morale, productivity, performance and retention of valued staff, and has played a key role in quantifiably lifting the operating “climate” of the workplace. It has helpe...
|
2022-02-12T23:02:51.537Z
|
128,036,555 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.11361/journalcpij.47.799",
"MAG": "589066431",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://www.jstage.jst.go.jp/article/journalcpij/47/3/47_799/_pdf"
}
|
In recent years, traffic safety measure using road space reallocation has attracted attention. In Europe, these measures including Shared Space have been implemented, and recent papers have shown effects on traffic safety. In Japan, these measures have been implemented as applicable and effective measures on narrow streets. However, little research has been conducted on traffic speed in these streets. This study made a survey of vehicle speeds, and analyzed the relationship between pedestrian behavior and traffic speed on shared streets. This study applies path analysis to analyzed causal relationship in complex system. The result shows that causal relationship on shared streets.近年、街路のしつらえやデザインを利用した道路空間を再構築することによる交通安全対策手法が注目を集めており、欧州ではShared Spaceをはじめとしてその交通安全上の効果が示されている。我が国においても、このような手法は歩道の設置が困難な狭幅員の単断面街路においても歩車を共存させるための有効な手段として広がりを見せつつある。しかしながら、空間配分について検討するための基礎的な知見となる歩車が混在する単断面街路における自動車走行速度についてはまだまだ明らかになっていない。そこで本研究では、岡山市内の歩車が混在する単断面街路において、自動車走行速度と歩行者交通に関する現地調査を行った。575台の自動車走行速度を計測し、街路空間とそこを走行する自動車交通並びに歩行者交通の関係について分析した。その結果、歩車混在時における単断面街路でのこれらの因果関係について明らかになっている。
|
2022-03-25T01:12:05.604Z
|
197,570,086 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.35749/journal.v44i1.159",
"MAG": "2952277749",
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},
"license": null,
"status": null,
"url": null
}
|
Introduction and Aims. Refractive errors such as miopia, hyperopia and astigmatism in teenagers are common in Asian country nowadays. Gadget usage also influence the prevalence and incidence of refractive errors specially for miopia and astigmatism. Outdoor activities have positive impact to prevent miopia. The aim of this study is to report the role of outdoor activities as unique school program that could prevent refractive errors in Junior High School in rural area of Bali
Method. This is analytic descriptive study with cross sectional approach of 231 Pekutatan II Junior High School students taken in December 2016. This school located in rural area; 35,3 km from Jembarana and 60,5 km from Denpasar, the capital city of Bali. The area of the school is about 1500 m2, where 70% of the land are still vacant to natural habitat and this school had their own garden area that being organized by the students themselves after school hours. This school do not have computer extra curriculum as well.
Result. From 231 students there were only 14 students that have refractive errors consist of 5 boys and 9 girls, mostly aged 15 years. Six students (2%) were diagnosed as myopia and 8 students (3.4%) were diagnosed as compound astigmatism myopia. The length of gadget usage in this school were 1.66 hours and outdoor activities time were 4.78 hours per day. The hereditary factors of refractive errors were noted in 12 students (5 %). Outdoor activities associated with refractive errors in this study (p = 0.03). While time using gadget does not have an association with the refractive errors (p = 0.38). Conclusion. Rural area where the outdoor activities are still common have protective effect to prevalence of refractive errors in teenager.
|
2022-02-08T06:34:02.851Z
|
231,750,794 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.7150/thno.53928",
"MAG": null,
"PubMedCentral": "7847672"
},
"license": "CCBYNC",
"status": "GOLD",
"url": "https://doi.org/10.7150/thno.53928"
}
|
A spheroid is an aggregation of single cells with structural and functional characteristics similar to those of 3D native tissues, and it has been utilized as one of the typical in vitro three-dimensional (3D) cell models. Scaffold-free spheroids provide outstanding reflection of tissue complexity in a 3D in vivo-like environment, but they can neither fabricate realistic macroscale 3D complex structures without avoiding necrosis nor receive direct external stimuli (i.e., stimuli from mechanical or topographical cues). Here, we propose a spheroid-laden electrospinning process to obtain in vitro model achieved using the synergistic effect of the unique bioactive components provided by the spheroids and stimulating effects provided by the aligned nanofibers. Methods: To show the functional activity of the spheroid-laden structures, we used myoblast-spheroids to obtain skeletal muscle, comprising highly aligned myotubes, utilizing an uniaxially arranged topographical cue. The spheroid-electrospinning was used to align spheroids directly by embedding them in aligned alginate nanofibers, which were controlled with various materials and processing parameters. Results: The spheroids laden in the alginate nanofibers showed high cell viability (>90%) and was compared with that of a cell-laden alginate nanofiber that was electrospun with single cells. Consequently, the spheroids laden in the aligned nanofibers showed a significantly higher degree of myotube formation and maturation. Conclusion: Results suggested that the in vitro model using electrospun spheroids could potentially be employed to understand myogenic responses for various in vitro drug tests.
|
2022-08-03T18:00:28.718Z
|
23,089,696 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.7861/CLINMEDICINE.4-4-369",
"MAG": "2169771778",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A study was carried out to find out whether more intense treatment (both medical and revascularisation) is targeted towards higher-risk patients with acute coronary syndromes. A prospective UK registry of patients admitted with non-ST elevation acute coronary syndromes was established to examine practice patterns and clinical outcomes with respect to the risk profile of the patients. Clinically important high-risk subgroups included the elderly, diabetics, those with heart failure and those with ST depression or bundle branch block on the presenting ECG. Elderly patients were less likely to receive evidence-based treatments, including beta blockers, statins and revascularisation. Diabetics received more revascularisation procedures but the overall revascularisation rate was low. Heart failure patients received less evidence-based treatment, with the exception of angiotensin-converting enzyme (ACE) inhibitors. Heparin was used less frequently in those with a normal ECG, although rates of revascularisation were not different when compared with those with ECG abnormalities. The conclusions of the study were that groups of patients with particularly high event rates are readily identified by their clinical characteristics, but use of evidence-based treatments and invasive investigations do not appear to be targeted towards those at greatest risk. Risk stratification and the appropriate application of treatments for patients with acute coronary syndromes need to be reviewed in the clinical setting.
|
2022-09-11T04:28:43.783Z
|
6,479,796 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ROBOT.2005.1570280",
"MAG": "2101072326",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The particular geometry of panoramic cameras defines complex epipolar lines equations. In this paper, we present a way to warp images from a panoramic stereovision bench, so that the epipolar lines become parallel straight lines, thus allowing the use of an optimized fast pixel correlation based stereovision algorithm. The paper first introduces the geometric characterization of panoramic camera composed of parabolic and spherical mirrors, that computes both the intrinsic parameters of the system (mirror surfaces and intrinsic camera parameters) and the errors alignment between the mirrors. Then, it presents the warping equations that allow to generate rectified images. Calibration and stereovision results are presented.
|
2022-09-13T13:00:03.924Z
|
124,103,345 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S0308210500025932",
"MAG": "2328004460",
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},
"license": null,
"status": null,
"url": null
}
|
Synopsis Let ψ ∈ C2[0,1] be a positive function on (0, 1]. Under certain assumptions on ψ, the set is a pseudoconvex domain with C2-boundary, for which it is possible to construct a Henkin-type operator Hψ = Kψ + Bψ solving in Dψ. The operator Bψ, is L∞-continuous because it has a Riesz potential type kernel, while the L∞-continuity of Kψ depends on the flatness of ψ at 0. Our main result states that Kψ is continuous from L∞(∂Dψ) into L∞(Dψ) if and only if
|
2022-12-04T20:27:50.713Z
|
12,944,421 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/1355785022000038560",
"MAG": "2030394954",
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},
"license": null,
"status": null,
"url": null
}
|
Objectives : This study sought to determine whether blacks and whites with life-threatening cardiac events differ in likelihood of help seeking, types of help sought, or likelihood of reaching the hospital before death. Design : Death certificates were used to identify all coronary heart disease-related deaths occurring in 1988-89 among 45- to 74-year-old, black and white, non-institutionalized residents of three contiguous inner-city districts in Boston, Massachusetts, USA. An informant was interviewed about the decedent's health status, access to care and pre-mortal help-seeking behaviors. Results : Among the 232 decedents analyzed, there were no racial differences in the likelihood of help seeking. Among those who sought help, there were no racial differences in the likelihood of reaching the hospital. However, blacks were more likely than whites to engage in two specific help-seeking behaviors: calling the 911 emergency system, and trying to reach an emergency room. Conclusion : In an area where blacks and whites were similar with respect to socioeconomic status and access to care, race did not affect the likelihood of help seeking or the likelihood of succeeding in reaching the hospital before death.
|
2022-12-28T20:07:24.634Z
|
150,347,656 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.19053/20275137.N17.2018.7453",
"MAG": "3015444758",
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"license": null,
"status": null,
"url": null
}
|
Este texto busca conocer las potencialidades de la enseñanza de las historias recientes para la construcción de ciudadanías múltiples y democráticas, que exigen una educación para la responsabilidad y la participación accionada a partir de enseñanzas con fundamento ético político. La investigación, de carácter cualitativo, se desarrolla en instituciones públicas de enseñanza elemental y media de varias ciudades de las provincias de Río Negro y Neuquén, y busca contribuir al conocimiento de la formación docente en historia. La enseñanza de la Historia Reciente es altamente compleja, por lo que su presencia se recontextualiza desde múltiples abordajes. Pensar en el presente históricamente conlleva un reto epistemológico y un replanteo acerca de modelos historiográficos. Sin embargo, ello no significa ausencia en las aulas. Si bien, dar cuenta de los procesos recientes en la enseñanza, les exige a los/as docentes revisar y repensar en torno a estos retos y desafíos, supondría que entienden su importancia desde el compromiso de posibilitar y favorecer a la formación de ciudadanías activas, críticas y responsables con los problemas de los presentes por venir. Cuestiones abordadas en el marco de contextos diversos y heterogéneos.
|
2022-05-20T06:10:44.159Z
|
228,977,273 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5194/nhess-2020-340",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GREEN",
"url": "https://nhess.copernicus.org/articles/21/2523/2021/nhess-21-2523-2021.pdf"
}
|
Abstract. The Bay of Bengal is a well-known breeding ground to some of the deadliest cyclones in history. Despite recent advancements, the complex morphology and hydrodynamics of this large delta and the associated modelling computational costs impede the storm surge forecasting in this highly vulnerable region. Here we present a proof of concept of a physically consistent and computationally efficient storm surge forecasting system tractable in real-time with limited resources. With a state-of-the-art wave-coupled hydrodynamic numerical modelling system, we forecast the recent super cyclone Amphan in real-time. From the available observations, we assessed the quality of our modelling framework. We affirmed the evidence of the key ingredients needed for an efficient, real-time surge and inundation forecast along this active and complex coastal region. This article shows the proof of the maturity of our framework for operational implementation, which can particularly improve the quality of localized forecast for effective decision-making.
|
2022-11-25T01:12:12.342Z
|
86,151,673 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/ARCH.940300208",
"MAG": "2154188669",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Baculovirus insecticides are receiving renewed attention as insect pest control agents following the development of fast-acting recombinant baculoviruses. Here we report on the construction and biological activity of a recombinant baculovirus derived from the nuclear polyhedrosis virus of Autographa californica which expresses a modified form of juvenile hormone esterase (JHE). The serine at the catalytic site of the JHE has been mutated to a glycine residue so that the protein does not degrade JH. The recombinant baculovirus expressing this modified form of JHE, named AcJHE-SG, has enhanced activity against lepidopteran larvae. Lethal times of the recombinant are 20 to 30% lower than for the wild type virus, and a 66% reduction in feeding damage caused by infected larvae is observed. This result is comparable to the best recombinant baculovirus developed to date, AcAaIT, which expresses an insect-selective scorpion toxin. The potential of these recombinant viruses for commercialization as insecticides is discussed. Bioassays of AcJHE-SG in conjunction with anti-JH agents indicate that the virus is not killing by an anti-JH mechanism. Larvae apparently die from contraction-paralysis, or disruption of the normal sequence of events at the molt. © 1995 Wiley-Liss, Inc.
|
2022-12-18T07:32:21.745Z
|
193,814,747 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.34024/revbea.2017.v12.2387",
"MAG": "2624038594",
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://periodicos.unifesp.br/index.php/revbea/article/download/2387/1495"
}
|
Este estudo objetivou analisar as letras musicais do carimbo de Marapanim-PA relacionadas a cultura, meio ambiente e Educacao Ambiental. Estas composicoes musicais foram adquiridas junto aos representantes dos grupos locais de carimbo: Japiim, Os originais, Flor do Mangue e Flor da Cidade. Verificou-se que as referidas letras musicais expressavam a religiosidade, os costumes, as crencas locais e, na maioria das vezes, o cotidiano do homem rural e do seu trabalho agroextrativista, alem de incluir a contemplacao e protecao dos recursos naturais em seus versos poeticos e, em alguns casos, ate estimulando o senso critico dos ouvintes em relacao aos problemas socioambientais, o que pode ser um importante instrumento de difusao e debate da EA nos distintos espacos de ensino.
|
2022-02-08T08:19:04.590Z
|
44,915,063 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5694/J.1326-5377.1993.TB121748.X",
"MAG": "2418149453",
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},
"license": null,
"status": null,
"url": null
}
|
The variety of problems induced by HIV means that any one of a wide range of investigations may uncover the first clue to unsuspected infection. Some of the more common abnormalities reported on by pathologists and radiologists which should raise the thought of underlying HIV infection are listed in this summary.
|
2022-02-12T01:01:25.903Z
|
225,187,212 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/min10090778",
"MAG": "3081706956",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://doi.org/10.3390/min10090778"
}
|
Pyrophyllite is extensively used in the high-pressure synthesis industry as a pressure-transmitting medium because of its outstanding pressure transmission, machinability, and insulation. Therefore, the atomic structure, electronic, and mechanical behavior of pyrophyllite [Al4Si8O20(OH)4] under high pressure should be discussed deeply and systematically. In the present paper, the lattice parameters, bond length, the electronic density of states, band structure, elastic constants, and mechanical parameters of pyrophyllite are investigated using density functional theory (DFT) from a microscopic perspective. The pressure dependence of atomic structure, electronic, and mechanical properties of pyrophyllite is analyzed for a wide range of pressure (from 0 GPa to 13.87 GPa). Under high pressure, the major bond lengths and layer thicknesses decrease slightly, and mechanical properties are improved with increasing pressure. The calculated electronic and band structures show only a slight change with increasing pressure, implying that the effect of pressure on the electronic property of pyrophyllite is weak, and pyrophyllite still has good stability under high pressure. The theoretical calculations presented here clarify the electronic and mechanical properties of natural pyrophyllite that are difficult to obtain experimentally because of their small particle size.
|
2022-12-10T09:50:42.641Z
|
143,461,393 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/(SICI)1099-0720(199806)12:3<251::AID-ACP510>3.0.CO;2-F",
"MAG": "2007074038",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The relationship between organization of knowledge in memory and level of proficiency in the performance of a complex cognitive task was evaluated. Based on their performance in a scenario, 42 Electronic Warfare (EW) technicians were categorized into 3 performance levels. To measure the organization of knowledge, the EWs rated all possible pairs of 24 concepts on degree of relatedness, and a Pathfinder net was created for each subject and for 2 expert EWs. A correlation of 0.40 between performance scores and a concept similarity measure indicates a significant positive association between level of proficiency and knowledge organization. Both high and intermediate performance groups produced nets that were more similar to the expert net than were those of the low performance group. © 1998 John Wiley & Sons, Ltd.
|
2022-12-11T10:02:59.967Z
|
11,006,546 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2341/07-145",
"MAG": "2131145837",
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},
"license": null,
"status": null,
"url": null
}
|
OBJECTIVES
To evaluate the use of two alternative modes of application (double-application and placement of a hydrophobic resin coat) compared with the manufacturers' directions on the microtensile bond strength (microTBS) of one-step, self-etch systems to enamel and dentin.
MATERIALS AND METHODS
Resin composite buildups were bonded to the buccal and lingual ground enamel surfaces and occlusal dentin of third molars using the following adhesives: Xeno III (XE), GBond (GB), Adper Prompt L-Pop (AD) and Clearfil SE Bond (CSE) as the control. The adhesive systems were applied: (1) following the manufacturer's directions (MD), (2) with double-application (DA) or with (3) additional placement of a hydrophobic resin layer (HR) after following the manufacturer's directions. After storage in water (24 hours/37 degrees C), the bonded specimens were sectioned into sticks (0.8 mm2) that were tested until failure at a crosshead speed of 0.5 mm/minute. Data from each substrate were subjected to two-way ANOVA and Tukey's test (alpha = 0.05).
RESULTS
The interaction Adhesive vs. Application mode was statistically significant (p < 0.05) for both substrates. In dentin, XE and GB achieved high microTBS in the HR group (p < 0.05). For AD, the highest microTBS were observed in the DA group (p < 0.05). For enamel, similar microTBS was observed for XE and GB among the three modes of application, while the highest pTBS of AD was observed in the HR group.
CONCLUSION
The effects of using the double-application and placement of a hydrophobic resin coat on microtensile dentin-bond strength values seem to be effective; however, these techniques in enamel were adhesive-dependent.
|
2022-12-16T13:05:03.428Z
|
152,871,613 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.12660/RBFIN.V7N3.2009.1309",
"MAG": "1531398495",
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},
"license": null,
"status": null,
"url": null
}
|
Securitization is a modality of structured finance which allows a company to raise funds based on its receivables through capital markets. In Brazil, securitization was developed mostly in the form of mutual funds -- the FIDC, which raise money by issuing senior cotes for qualified investors, and subordinated cotes, usually bought by the company that originated the receivables. This paper evaluates the risk and return for both kinds of investors through a stochastic model with two main variables: interest rates and default rates. The model is still sensible to the characteristics of the fund, like the amount of subordinated cotes, the type of asset being securitized; and the amount of receivables in relation to the assets. Regarding the case of senior cotes, the risk of returns under the basic level of interest rates is highly improbable; and in the case of subordinated cotes, the risk of returns under the basic interest rate may be considered still low, due to the high spreads observed in the Brazilian financial market. The simulations indicated that under historically mean interest rate volatility the default rates are the main component of the total risk. Accordingly to the developed analysis of international standards of regulation, the Brazilian Central Bank imposes very strong capital requirements to banks that securitize their assets and purchase the corresponding subordinated cotes.
|
2022-12-16T13:06:22.710Z
|
220,433,044 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1080/15287390500177024",
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}
|
Eupatilin, an extract from Artemisia asiatica Nakai, is known to exert anti-gastric ulcer, anticancer, and anti-inflammatory effects. The aim of this study was to elucidate whether eupatilin has antiallergic reactions in activated guinea pig lung mast cells compared to apigenin and genistein. Mast cells were purified from guinea pig lung tissues by using enzyme digestion and rough and discontinuous density Percoll gradient. The purified mast cells were sensitized with immunoglobulin (Ig) G1 (anti-OVA antibody) and challenged with ovalbumin (OVA). Histamine was assayed using an automated fluorometric analyzer, leukotrienes by radioimmunoassay, and tyrosine phosphorylation by immunoblotting. Intracellular Ca2+ was analyzed by confocal laser scanning microscopy, protein kinase C (PKC) activity using protein phosphorylated with [γ-32P]ATP, and phopholipase D activity (PLD) and phosphatidic acid by using labeled phosphatidyl alcohol. Eupatilin, apigenin, or genistein reduced histamine release and leukotriene synthesis in a does-dependent manner. Eupatilin inhibited mediators to a greater extent than apigenin or genistein. Eupatilin, apigenin, and genistein initially blocked phosphorylation of Syk tyrosine and Ca2+ influx, PLD activity, phosphatidic acid, and Ca2+-dependent PKC α/βII activities during mast cell activation in a dose-dependent manner. Our data suggest that eupatilin initially inhibits Syk kinase, and then blocks downstream multisignal pathways and Ca2+ influx during mast cell activation triggered by a specific antigen–antibody reaction. Thus, eupatilin may have use clinically as a treatment for inflammatory disorders associated with allergic diseases including asthma.
|
2022-12-18T15:33:36.869Z
|
8,258,204 |
{
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"ArXiv": null,
"DOI": "10.1021/jacs.6b12187",
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"url": null
}
|
Single-component molecular conductors can provide a variety of electronic states. We demonstrate here that the Dirac electron system emerges in a single-component molecular conductor under high pressure. First-principles density functional theory calculations revealed that Dirac cones are formed in the single-component molecular conductor [Pd(dddt)2] (dddt = 5,6-dihydro-1,4-dithiin-2,3-dithiolate), which shows temperature-independent resistivity (zero-gap behavior) at 12.6 GPa. The Dirac cone formation in [Pd(dddt)2] can be understood by a tight-binding model. The Dirac points originate from the HOMO and LUMO bands, each of which is associated with different molecular layers. Overlap of these two bands provides a closed intersection at the Fermi level (Fermi line) if there is no HOMO-LUMO coupling. Two-step HOMO-LUMO couplings remove the degeneracy on the Fermi line, resulting in gap formation. The Dirac cones emerge at the points where the Fermi line intersects with a line on which the HOMO-LUMO coupling is zero.
|
2022-12-17T17:33:25.908Z
|
110,373,948 |
{
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"ArXiv": null,
"DOI": "10.1191/0142331203tm092oa",
"MAG": "2035018511",
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},
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"status": null,
"url": null
}
|
New therapies, such as cell implants, will in future require teleoperators capable of repeatable positioning accuracy of 10 mm and better. This paper describes the design of a Stewart platform (hexapod robot system) which can be used for precision microsurgery in a number of different medical disciplines. The system design is discussed in detail and an overview of potential applications is given. Also, results are reported on the application in neuroendoscopy.
|
2022-12-29T16:27:18.183Z
|
162,255,140 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S0041977X00010636",
"MAG": "2068000610",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
1960. This includes commercial ventures of the East India Company, its administration after it took over the government of the country, India under the British rule, and the early years of independent India. The present volume provides detailed description of eleven Ministries of the Government of India out of a total of nineteen which existed in 1960. Information about the remaining eight Ministries and private records in the custody of the National Archives of India will be presented in vol. 3, no. 2 of the series. Here there are eleven chapters dealing with each Ministry individually. They are arranged alphabetically and no indication is given of the relative importance of the records of one Ministry over the other. Each chapter gives the genesis of the present structure of the Ministry concerned, its organizational history from the beginning, and the functional changes made from time to time. A list of some documents of both Indian and international importance, with their references, has also been appended. The guide should thus enable the reader to evaluate the nature and importance of the documents available in each Ministry. It also provides a brief history of the archives, access regulations, opening hours and photographic services. As such it is a useful source of information on the rich collections of the National Archives which should help to promote research in a wide range of subjects.
|
2022-02-09T02:08:54.027Z
|
170,110,202 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.17951/KW.2015.14.51",
"MAG": "2296431614",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Der Artikel ist ein Versuch der philosophischen Interpretation der Figur des Grosinquisitors – einer im Roman Die Bruder Karamasow von Fiodor Dostojewski entworfenen Gestalt. Die vorgeschlagene Interpretation greift auf die geschichtsphilosophisch-politischen Meinungen des russischen Schriftstellers zuruck, die aus seinen publizistischen Auserungen stammen. Die durchgefuhrten Analysen lassen einen inneren Zusammenhang zwischen der literarischen Figur des Grosinquisitors mit dem Konzept der „russischen Idee“, in der sich Religion und Politik gemeinsam erganzen (und eine eigenartige Variante politischer Theologie bilden).
|
2022-02-08T17:30:51.183Z
|
20,287,727 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.21236/ada583979",
"MAG": "1514014239",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Abstract : Dystonia is the 3rd most common movement disorder, and some forms are brought on by stress. Investigators have not yet succeeded in making a genetic mouse model of dystonia by conventional approaches. A novel strategy was designed to combine three mutant mouse strains together by breeding to reduce the expression of a protein known to be mutated in an inherited human dystonia triggered by stress. There were problems with one of the mouse strains, however, which lost one of its genetic modifications, and a different strategy was adopted. This was successful, and a mouse with the desired dystonic symptoms was obtained. It has two mutations, one a dominantly inherited gene with 100% penetrance, and the other a strain-specific modifier gene that controls how strong the symptoms are. These genes were mapped to two loci on two different chromosomes. The behavior of the mouse was extensively characterized. Swim stress brought about very severe symptoms, but the mice fully recovered to a moderate dystonic baseline. As planned, electrophysiology and electromyography were performed, showing the co-contraction of opposing muscles, the hallmark of dystonia.
|
2022-02-12T22:15:50.714Z
|
40,790,700 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/ietcom/e90-b.7.1674",
"MAG": "2083832991",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A method for flexibly allocating and reallocating optical access network (OAN) resources, including fibers and equipment, using the constraint satisfaction problem (CSP) is described. OAN resource allocation during service delivery provisioning involves various input conditions and allocation sequences, so an OAN resource allocation method has to support various workflow patterns. Furthermore, exception processing, such as reallocating OAN resources once they are allocated, is inevitable, especially during the spread of service using optical fiber and during the deployment of an optical access network. However, it is almost impossible to describe all workflow patterns including exception processes. Improving the efficiency of these exception processes, as well as that of the typical processes, is important for reducing the service delivery time. Describing all these patterns and process flows increases development cost. The CSP can be used to search for solutions without having to fix the process sequence and input conditions beforehand. We have formulated the conditions for OAN resource allocation and reallocation as a CSP. Use of this method makes it possible to handle various allocation workflow patterns including exception processes. Evaluation of the solution search time demonstrated its feasibility.
|
2022-02-12T04:08:08.883Z
|
199,466,862 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1152/ajplung.00080.2018",
"MAG": "2966288204",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://journals.physiology.org/doi/pdf/10.1152/ajplung.00080.2018"
}
|
Changes in reactive oxygen species and extracellular matrix seem to participate in pulmonary hypertension development. Since we recently reported evidence for chronic hypoxia decreasing expression of cartilage oligomeric matrix protein (COMP) and evidence for this controlling loss of pulmonary arterial smooth muscle BMP receptor-2 (BMPR2) and contractile phenotype proteins, we examined if changes in superoxide metabolism could be an important factor in a bovine pulmonary artery (BPA), organoid cultured under hypoxia for 48hrs model. Hypoxia (3% oxygen) caused a depletion of COMP in BPA, but not in bovine coronary arteries. Knockdown of COMP by siRNA increased BPA levels of mitochondrial and extra-mitochondrial superoxide detected by MitoSOX and dihydroethidium (DHE) HPLC products. COMP siRNA treated BPA showed reduced levels of SOD2 and SOD3 and increased levels of NADPH oxidases NOX2 and NOX4. Hypoxia increased BPA levels of MitoSOX detected superoxide, and caused changes in NOX2 and SOD2 expression similar to COMP siRNA, and exogenous COMP (0.5μM) prevented the effects of hypoxia. In the presence of COMP, BMPR2 siRNA treated BPA showed increases in superoxide detected by MitoSOX and depletion of SOD2. Scavenging superoxide (0.5μM TEMPO or mitoTEMPO) maintained the expression of contractile phenotype proteins Calponin and SM22α decreased by 48hrs hypoxia (1% oxygen). Adenoviral delivery of BMPR2 to rat pulmonary artery smooth muscle cells prevented the depletion of Calponin and SM22α by COMP siRNA. Thus, COMP regulation of BMPR2 appears to have an important role in controlling hypoxia-elicited changes in BPA superoxide and its potential regulation of contractile phenotype proteins.
|
2022-08-27T12:33:36.957Z
|
18,415,238 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3389/fped.2014.00043",
"MAG": "2027328518",
"PubMedCentral": "4030189"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.frontiersin.org/articles/10.3389/fped.2014.00043/pdf"
}
|
We revisit the technique of total preputial flap (TPF) and its application for urethroplasty, penile skin coverage of both and present our results in 43 patients (41 hypospadias, 2 epispadias). There were no instances of flap necrosis. In patients without prior attempts at reconstruction (n = 36), we observed four urethrocutaneous fistulas. TPF allowed the repair of cases of proximal hypospadias in one stage with an acceptable complication rate.
|
2022-09-30T06:34:01.689Z
|
238,242,112 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/CLEO/Europe-EQEC52157.2021.9542412",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Yb 3+ (Yb)-doped monoclinic oxoborates Ca 4 REO(BO 3 ) 3 where RE stands for Gd or Y (denoted as GdCOB and YCOB, respectively) feature the advantages of extremely flat and smooth gain profile due to the significant inhomogeneous broadening related to their disordered structure, large ground state splitting of >1000 cm -1 , good thermo-optic properties as well as polarized emission due to the natural birefringence (acentric monoclinic symmetry), which makes them attractive for the development of tunable and sub-100-fs solid-state lasers in the 1-μm spectral region [1] - [3] and self-frequency doubling. In mixed Yb:Ca 4 Gd x Y 1-x O(BO 3 ) 3 (shortly Yb:GdYCOB) crystal with a partial substitution of Y 3+ by Gd 3+ ions is expected to provide additional broadening of the spectral bands due to the compositional disorder [4] , [5] . Here, we report on a Kerr-lens mode-locked (KLM) operation of Yb:GdYCOB laser generating pulses as short as 43 fs with an average power of 84 mW at 1036.5 nm and a pulse repetition rate of ~70 MHz.
|
2022-12-16T09:17:26.105Z
|
155,662,573 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.17813/MAIQ.2.2.W6087622383H4341",
"MAG": "2281447213",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This article presents an approach to the study of the consequences of social movements that focuses on their capacity to produce "social capital." By social capital I mean ties that are based on mutual trust and mutual recognition among the actors involved in the relationship, although they do not necessarily imply the presence of collective identity. The influence of social movements may be regarded as dependent on their structural position, i.e., on the solidity of the linkages within the movement sector as well as—more crucially—of the bonds among movement actors, the social milieu in which they operate, and cultural and political elites. Therefore, the impact of a given movement or movement sector will be assessed in the light of changes in its components' relative centrality in various social networks. The broader the range of social capital ties emerging from a period of sustained mobilization, the greater the impact.
|
2022-12-20T22:04:26.507Z
|
216,122,267 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.18502/kls.v5i3.6571",
"MAG": "3012150228",
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},
"license": null,
"status": "GOLD",
"url": "https://knepublishing.com/index.php/KnE-Life/article/download/6571/12083"
}
|
Indonesia has one of the greatest diversities in the world as reflected by its many cultures, languages, customs, and beliefs. This diversity can be easily seen in the East Java region which, despite its Javanese ethnic majority, is also populated by other ethnics, sub ethnics, and mixed groups. Shadow puppet theatre is a form of public attraction long existing in Java, even before the era of the Majapahit Empire. It is usually performed at night and takes a considerable time. In this multidisciplinary paper, it is hypothesized that good time management will increase audience satisfaction and in turn contribute to the sustainability of the theatre and Javanese culture. Based on the analysis of the survey, using partial least square by java web start program, it is found that, first, shadow puppet attraction positively affects to time management as 0.720. Further, the attraction leads to audience satisfaction as 0.558. Lastly, time management affects audience satisfaction as 0.258.
Keywords: audience satisfaction; wayang attraction; wayang time management.
|
2022-01-27T12:04:48.471Z
|
227,911,580 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3877/CMA.J.ISSN.2095-8757.02.007",
"MAG": "3031638454",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Clinical diagnosis of Alzheimer’s disease (AD) is difficult in early stages. Reliable biomarkers are required for diagnosis of AD. The detection of miRNAs which is stable in peripheral blood is an ideal means of performing early screening because of its convenience, non-invasiveness, and suitability for screening large populations. This paper introduces the miRNAs detection in serum, blood mononuclear cells, whole blood or plasma in Alzheimer's disease, providing a new method for AD diagnosis.
Key words:
Alzheimer’s disease; micro RNA; Peripheral blood
|
2022-01-27T01:49:19.024Z
|
151,875,826 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1163/9789401201292_010",
"MAG": "2601331587",
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},
"license": null,
"status": null,
"url": null
}
|
This essay’s initial line of inquiry examines how race and sexuality function in the Matrix trilogy. Though the films cultivate a pan-ethnic aesthetic, this attempt to signal a future in which humanity unifies across racial boundaries against a non-human threat ultimately reveals itself to be a superficial bronzing over of racial differences rather than an earnest consideration of race as a social construct. Despite the films’ central dogma of questioning “what is real,” the Matrix trilogy lapses into essentialist racial divisions of reproductive labor. This essay studies the racialization of sexuality in the three Matrix films and then goes on to present one arena in which these stereotypes are conscientiously, playfully, and provocatively broken. The latter half of this essay, then, shifts its focus away from the films themselves and looks, instead, toward the still related but less regulated space of Matrix fandom and the slash fiction that imagines a reorganization of race and sexuality in the Matrix world. So, rather than lingering too long on the failings of the Matrix trilogy to deliver a more innovative futurescape, the essay turns to the ways in which fans wrest control of the films from the filmmakers to make good on the potential they saw in the original Matrix premise. This move is made with the guidance of cultural theorists such as Michel de Certeau and Constance Penley, both of whom argue for the agency residing in the everyday pedestrian, the consumer, the viewer, and the fan.
|
2022-09-11T10:25:16.170Z
|
228,084,206 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1029/2020GH000331",
"MAG": "3106496090",
"PubMedCentral": "7698020"
},
"license": null,
"status": null,
"url": null
}
|
Fires burning across the Amazon in the summer of 2019 attracted global attention for the widespread destruction of natural ecosystems and regional smoke production. Using a combination of satellite fire observations and atmospheric modeling, Nawaz and Henze (2020, https://doi.org.10.1029/2020GH000268) provide new evidence for the widespread regional public health consequences attributed to these fires. They find that approximately 10% of premature deaths in Brazil due to fine particulate matter (PM2.5) are attributable to smoke pollution and highlight how fire locations play a critical role in determining downwind health impacts.
|
2022-10-21T01:19:13.090Z
|
152,558,919 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.7765/9781847793034",
"MAG": "631532520",
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},
"license": null,
"status": null,
"url": null
}
|
Acknowledgements List of abbreviations Maps Introduction 1. Scotland in the eighteenth century 2. The eighteenth-century West Indies 3. Scots on the plantations 4. Mercantile connections 5. Scots doctors in the West Indies 6. Scots in West Indian politics 7. Scots, the Caribbean and British politics 8. Repatriation from the West Indies Conclusion Bibliography Index
|
2022-09-15T22:17:11.472Z
|
2,237,896 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3389/fmicb.2018.00250",
"MAG": "2792930730",
"PubMedCentral": "5826065"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.frontiersin.org/articles/10.3389/fmicb.2018.00250/pdf"
}
|
Carboxylate reductases (CARs, E.C. 1.2.1.30) generate aldehydes from their corresponding carboxylic acid with high selectivity. Little is known about the structure of CARs and their catalytically important amino acid residues. The identification of key residues for carboxylate reduction provides a starting point to gain deeper understanding of enzymatic carboxylate reduction. A multiple sequence alignment of CARs with confirmed activity recently identified in our lab and from the literature revealed a fingerprint of conserved amino acids. We studied the function of conserved residues by multiple sequence alignments and mutational replacements of these residues. In this study, single-site alanine variants of Neurospora crassa CAR were investigated to determine the contribution of conserved residues to the function, expressability or stability of the enzyme. The effect of amino acid replacements was investigated by analyzing enzymatic activity of the variants in vivo and in vitro. Supported by molecular modeling, we interpreted that five of these residues are essential for catalytic activity, or substrate and co-substrate binding. We identified amino acid residues having significant impact on CAR activity. Replacement of His 237, Glu 433, Ser 595, Tyr 844, and Lys 848 by Ala abolish CAR activity, indicating their key role in acid reduction. These results may assist in the functional annotation of CAR coding genes in genomic databases. While some other conserved residues decreased activity or had no significant impact, four residues increased the specific activity of NcCAR variants when replaced by alanine. Finally, we showed that NcCAR wild-type and mutants efficiently reduce aliphatic acids.
|
2022-12-08T17:27:33.916Z
|
237,637,550 |
{
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"ArXiv": null,
"DOI": "10.1177/02630672211030187",
"MAG": "3178283528",
"PubMedCentral": null
},
"license": "CCBY",
"status": "HYBRID",
"url": "https://doi.org/10.1177/02630672211030187"
}
|
Peer supervision is a dynamic process which highlights constructive and supportive feedback among therapists while minimising feelings of being evaluated. Some of its benefits include decreased dependency on the expertise of a supervisor, freedom, and equality. In this article, we outline the benefits of peer supervision between a dramatherapist and a family therapist and how their common roots based on creativity and action-based approaches could be used remotely to enhance the goals of peer supervision. We discuss how we utilised such methods and more specifically role reversal in a virtual space during the first Covid-19 lockdown to facilitate the process of peer supervision and understand better the needs and perspective of the client. We propose that incorporating creative and spontaneous methods such as role reversal in a virtual peer supervision environment can potentially enhance the supervisory alliance and therapeutic practice.
|
2022-11-25T00:37:04.957Z
|
30,155,728 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S1431927614000075",
"MAG": "1999061206",
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},
"license": null,
"status": null,
"url": null
}
|
Abstract In this study, a combined tilt- and focal series is proposed as a new recording scheme for high-angle annular dark-field scanning transmission electron microscopy (STEM) tomography. Three-dimensional (3D) data were acquired by mechanically tilting the specimen, and recording a through-focal series at each tilt direction. The sample was a whole-mount macrophage cell with embedded gold nanoparticles. The tilt–focal algebraic reconstruction technique (TF-ART) is introduced as a new algorithm to reconstruct tomograms from such combined tilt- and focal series. The feasibility of TF-ART was demonstrated by 3D reconstruction of the experimental 3D data. The results were compared with a conventional STEM tilt series of a similar sample. The combined tilt- and focal series led to smaller “missing wedge” artifacts, and a higher axial resolution than obtained for the STEM tilt series, thus improving on one of the main issues of tilt series-based electron tomography.
|
2022-12-15T04:03:47.588Z
|
8,136,456 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/TMAG.2011.2172990",
"MAG": "2139559067",
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},
"license": null,
"status": null,
"url": null
}
|
This paper presents an analysis method that combines the nondestructive resonant electromagnetic testing and the mathematical model for determining the thickness and conductivity of molybdenum (Mo) thin layer in copper indium gallium selenide (CIGS) solar cells. This technique is demonstrated for Mo layers (0.5-1.5 μm) over glass substrate. The impedance of probe coils and sheet resistance were measured by using 4294A Hewlett-Packard impedance analyzer and RT-9 Napson four-point probe to verify the analytical data. Analytic solutions for calculating the coil impedance of EC probe above Mo thin layers are presented. The conductivity is considered with sheet resistances and thicknesses. The estimation of thickness and sheet resistance of Mo thin layers is based on the linear regression of the measured data and theoretical calculations. As anticipated, the proposed method shows that the coil's impedance largely relates to the sheet resistance and the thickness of Mo layers. Two Mo layers with different manufacturing process and unknown characteristics also inspected and analyzed for comparison. The results show that the agreement between experimental and analytical data is within a small deviation.
|
2022-12-18T06:20:25.024Z
|
59,157,036 |
{
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"ArXiv": null,
"DOI": "10.4172/2168-9881.1000116",
"MAG": "2139409608",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Fruits and vegetables have now been documented as neutraceuticals or functional foods useful for health and medical benefits including prevention and treatment of diseases. With the background of ethno medicinal evidences and the view to utilize the wild fruit resources of Odisha, India as functional food enriched with antioxidants, 4 wild edible fruits were studied for in vitro radical scavenging activity and antioxidant enzymes such as Peroxidase, Catalase and Superoxide dismutase (SOD) following standard methods. It was found that the fruit with highest DPPH scavenging activity is Antidesma ghaesembilla (1020.6 AEAC mg/100 g dwt) and the lowest recorded in Morinda tinctoria (235 AEAC mg/100 g dwt). The highest FRAP value was recorded in Antidesma ghaesembilla (2114 μM AEAC/g dwt) and the fruit with lowest FRAP value was Careya arborea (538 μM AEAC/g dwt) Antidesma ghaesembilla showed the highest Peroxidase value of 1.12 OD/min/g tissue wt while the lowest was found in Morinda tinctoria (0.054 OD/min/g tissue wt). Catalase was found in high amounts in Antidesma ghaesembilla (5.4×104 IEU/g fresh tissue), the lowest value was observed in Dillenia pentagyna (1.2×104 IEU/g fresh tissue). Similarly for superoxide dismutase (SOD), the highest value was recorded in Morinda tinctoria (4.43 Δ OD/min/mg protein) and lowest in Careya arborea (1.12 Δ OD/min/mg protein). Current research reveals that these wild edible fruits, especially Antidesma ghaesembilla are rich source of antioxidants and can further be subjected to identification of individual compounds responsible for such high antioxidant activity.
|
2022-12-18T12:48:19.867Z
|
73,729,240 |
{
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"ACL": null,
"ArXiv": "1903.03697",
"DOI": "10.15607/RSS.2019.XV.066",
"MAG": "2965414970",
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},
"license": null,
"status": null,
"url": null
}
|
We consider the problem of vehicle routing for Autonomous Mobility-on-Demand (AMoD) systems, wherein a fleet of self-driving vehicles provides on-demand mobility in a given environment. Specifically, the task it to compute routes for the vehicles (both customer-carrying and empty travelling) so that travel demand is fulfilled and operational cost is minimized. The routing process must account for congestion effects affecting travel times, as modeled via a volume-delay function (VDF). Route planning with VDF constraints is notoriously challenging, as such constraints compound the combinatorial complexity of the routing optimization process. Thus, current solutions for AMoD routing resort to relaxations of the congestion constraints, thereby trading optimality with computational efficiency. In this paper, we present the first computationally-efficient approach for AMoD routing where VDF constraints are explicitly accounted for. We demonstrate that our approach is faster by at least one order of magnitude with respect to the state of the art, while providing higher quality solutions. From a methodological standpoint, the key technical insight is to establish a mathematical reduction of the AMoD routing problem to the classical traffic assignment problem (a related vehicle-routing problem where empty traveling vehicles are not present). Such a reduction allows us to extend powerful algorithmic tools for traffic assignment, which combine the classic Frank-Wolfe algorithm with modern techniques for pathfinding, to the AMoD routing problem. We provide strong theoretical guarantees for our approach in terms of near-optimality of the returned solution.
|
2022-12-31T17:38:27.736Z
|
112,643,224 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.5377/CE.V7I2.2518",
"MAG": "2341181361",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The purpose of this research is to reveal the characteristics required of the graduate profile of the first professional aviation career on civil aviation area in Honduras, to define based on this ideal profile required curriculum content, structure learning spaces of each subject, aeronautical guidelines to be proposed, the duration of this career and the number of classes and credit units must include. The methodology included a literature review that realizes trends in international aviation environment The purpose of this research is to reveal the characteristics required of the graduate profile of the first professional aviation career on civil aviation area in Honduras, to define based on this ideal profile required curriculum content, structure learning spaces of each subject, aeronautical guidelines to be proposed, the duration of this career and the number of classes and credit units must include. The methodology included a literature review that realizes trends in international aviation environment Revista Ciencias Espaciales, Vol. 7(2) 2014, 14-33
|
2022-02-10T03:05:40.180Z
|
121,244,592 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4028/www.scientific.net/AMR.538-541.2481",
"MAG": "2030208341",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Stochastic response surface methods (SRSM) based on polynomial chaos expansion (PCE) has been widely used for uncertainty propagation. It is necessary to select efficient sampling technique to estimate the PCE coefficients in SRSM. In this paper, the three advanced sampling approaches, namely, Gaussian Quadrature point (GQ), Monomial Cubature Rule (MCR), and Latin Hypercube Design (LHD) are introduced and investigated, whose performances are tested through several examples. It is shown that the results of UP for the three sampling approaches show great agreements to those of Monte Carlo simulation. Specifically, GQ yields the most accurate result of UP, followed by MCR and LHD, while MCR shows the best efficiency for lower PCE order.
|
2022-07-29T12:13:11.323Z
|
221,396,062 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1600-0447.1975.tb02263.x",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The group of diseases called “inborn errors of metabolism” are usually characterized by an inherited defect of an enzyme leading to a metabolic block with accumulation of metabolites before and lack of metabolites behind the block. The substrate which cannot be properly degraded because of such a block is metabolized in other pathways and induces an accumulation of products on these pathways, leading to further biochemical disturbances and to abnormally high demands for vitamins, which act as coenzymes. The dietary restriction of the compound which cannot be properly metabolized reduces accumulation of metabolites and prevents the metabolic shift, and thus further biochemical abnormalities. If replacement of the defective enzyme is not possible, the supplementation of missing products, together with dietary treatment, often prevents the clinical manifestation of the inborn error of metabolism. In phenylketonuria (PKU), an inherited enzymatic defect leads to deviations in the degradation of phenylalanine followed by abnormally high levels of several phenylalanine (P) derivatives in the urine. Clinically, PKU is characterized by usually severe retardation of mental development. Early dietary restriction of phenylalanine can prevent the shift of P metabolism to minor pathways, normalize urinary findings, and prevent mental retardation. In schizophrenia, abnormally high urinary levels of tryptophan derivatives have been found, especially during acute exacerbation of psychotic behaviour. Some of these tryptophan derivatives-DMT, bufotenin and 5-MeO-DMT-have psychotogenic properties, and in animals and normal individuals, especially after pretreatment with M A 0 inhibitors. they can induce abnormal behaviour, including hallucinations and catatonia. A tryptophan load can induce exacerbations of psychotic symptoms in schizophrenics ; such exacerbations are accompaniedas are spontaneous exacerbations-by increased levels of tryptophan derivatives in the urine. These findings suggest that, in schizophrenia, there is some defect in tryptophan metabolism and that restriction of dietary tryptophan might reduce accumulation of tryptophan metabolites, prevent the shift of tryptophan metabolism to other metabolic pathways and, thus, prevent the production of psychotogenic tryptophan derivatives .
|
2022-01-27T01:31:18.640Z
|
17,543,780 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/SOLI.2008.4682853",
"MAG": "2150851808",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
With the development of information technology, more and more enterprises have determined to make investment on ERP project. Whether or not to make this investment can be regarded as a option for the company. This paper introduces the characteristic of ERP system first, and analyzes the investment, then brings option theory into ERP investment to evaluate the value of investment. The approach of evaluating value includes traditional NPV of expected cash flow and the option value of operating.
|
2022-02-13T00:25:01.543Z
|
216,092,029 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/14043850410010739",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The article aims at describing and analyzing drug policy and drug control in relation to Nordic criminal policy and criminal law policy. The background of the analysis is a remarkable inconsistency between, on the one hand, Nordic criminal policy in general and, on the other hand, drug control policy. The general criminal policy requires rationality and humanism, accentuating the importance of limiting penal solutions to cases where this is ultimo ratio. A limited use of imprisonment and a low incarceration rate have long been considered to be essential goals in themselves. But for drug policy we can observe a quite opposite attitude. Drugs must be strongly combated, and the means are primarily penal. The core questions to be examined in this article are how this inconsistency has come about and what the consequences of these two opposite attitudes are. The article begins with a description of how the drug policy has developed. Use of drugs was for a long time defined as an individual, medicinal or social problem. But since the beginning of the 1960s, drug use has been considered to be a crime problem, often as the most serious one. Afterwards a short description will be given of how penal legislation, rules of criminal procedure, and crime control have changed in order to achieve a more effective combat of drug crimes. Finally the present situation is described and analyzed from the perspective of whether it can be considered as a sound drug policy, a sound criminal policy, and sound criminal law policy to use imprisonment as extensively as it is done in the area of drug control. Is it rational and is it just to fill the prisons with drug offenders to the extent it is presently done?
|
2022-08-28T16:31:56.862Z
|
171,719,529 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.15802/AMPR2013/17047",
"MAG": "2601165840",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Цель. Высказываются опасения, что «METI-проекты», которые свидетельствуют о существовании человечества как техногенной цивилизации для высокоразвитых ВЦ Галактики, могут иметь крайне негативные последствия, а «SETI-проекты» и полученные радиосигналы могут стать информационным оружием агрессивной ВЦ. Анализ этих опасений как целостного социокультурного феномена, их философско-антропологические измерения, социокультурные основания, формы их проявления являются целью статьи. Методология. Автор использовал социально-коммуникативный подход, методы системного и кластерного анализов. Научная новизна . Раскрыты философско-антропологические измерения проблемы бытия внеземного разума (ВР), исследованы факторы постановки проблемы контактов с ВЦ в современной форме, связанные с космизацией научно-технической деятельности человечества, влияние процессов глобализации на философско-антропологические аспекты проблемы ВЦ, связанные с изменениями в фундаментальном отношении «Человек – Мир». Эти процессы ведут к росту опасений по поводу непредсказуемого вмешательства в земную социокультурную систему чуждого разума. Фобии, связанные с возможными последствиями контактов с ВЦ, принимают форму гипотез относительно внеземного искусственного интеллекта (ВИИ) как потенциального субъекта контакта. Рассмотрены позитивный и негативный сценарии диалога с ВИИ, проблемы «доброкачественности сигнала» и «SETI-хакера», связанные с ВИИ как субъектом космического диалога. Выводы. Дальнейшее развитие проблемы поиска ВЦ и установления контактов с ними будет связано, с одной стороны, с успехом (или отсутствием такового) в преодолении цивилизационного тупика, в котором оказалось человечество на рубеже ХХ – ХХI вв., а с другой, – углублением революции в космологии, прогрессом наблюдательной астрономии, философско-культурологической рефлексией над проблемой.
|
2022-10-07T00:43:34.692Z
|
4,922,876 |
{
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"ArXiv": null,
"DOI": "10.1097/CCM.0000000000003004",
"MAG": "2789817357",
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},
"license": null,
"status": null,
"url": null
}
|
Objectives: Sepsis, the acute organ dysfunction caused by a dysregulated host response to infection, poses a serious public health burden. Current management includes early detection, initiation of antibiotics and fluids, and source control as necessary. Although observational data suggest that delays of even a few hours in the initiation of antibiotics or IV fluids is associated with survival, these findings are controversial. There are no randomized data in humans, and prior animal studies studied time from experimental manipulation, not from the onset of clinical features of sepsis. Using a recently developed murine cecal ligation and puncture model that precisely monitors physiologic deterioration, we hypothesize that incremental hourly delays in the first dose of antibiotics, in the first bolus of fluid resuscitation, or a combination of the two at a clinically relevant point of physiologic deterioration during polymicrobial sepsis will shorten survival. Design: Randomized laboratory animal experimental trial. Setting: University basic science laboratory. Subjects: Male C57BL/6J, female C57BL/6J, aged (40–50 wk old) male C57BL/6J, and BALB/C mice. Interventions: Mice (n = 200) underwent biotelemetry-enhanced cecal ligation and puncture and were randomized after meeting validated criteria for acute physiologic deterioration. Treatment groups consisted of a single dose of imipenem/cilastatin, a single bolus of 30 mL/kg fluid resuscitation, or a combination of the two. Mice were allocated to receive treatment at the time of meeting deterioration criteria, after a 2-hour delay or after a 4-hour delay. Measurements and Main Results: Hourly delays in the initiation of antibiotic therapy led to progressively shortened survival in our model (p < 0.001). The addition of fluid resuscitation was unable to rescue animals, which received treatment 4 hours after meeting enrollment criteria. Systemic inflammation was increased, and host physiology was increasingly deranged with hourly delays to antibiotics. Conclusions: We conclude that antibiotic therapy is highly time sensitive, and efforts should be made to deliver this critical therapy as early as possible in sepsis, perhaps extending into the first point of medical contact outside the hospital.
|
2022-12-09T00:04:42.969Z
|
3,716,715 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1073/pnas.0510319103",
"MAG": "2070493739",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "http://www.pnas.org/content/103/27/10514.full.pdf"
}
|
Toxoplasma gondii, an obligate intracellular protozoan of the phylum Apicomplexa, is estimated to infect over a billion people worldwide as well as a great many other mammalian and avian hosts. Despite this ubiquity, the vast majority of human infections in Europe and North America are thought to be due to only three genotypes. Using a genome-wide analysis of single-nucleotide polymorphisms, we have constructed a genealogy for these three lines. The data indicate that types I and III are second- and first-generation offspring, respectively, of a cross between a type II strain and one of two ancestral strains. An extant T. gondii strain (P89) appears to be the modern descendant of the non-type II parent of type III, making the full genealogy of the type III clonotype known. The simplicity of this family tree demonstrates that even a single cross can lead to the emergence and dominance of a new clonal genotype that completely alters the population biology of a sexual pathogen.
|
2022-12-17T11:01:23.264Z
|
129,231,338 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1061/(ASCE)0733-9410(1996)122:12(998)",
"MAG": "1979580473",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Sinkhole development in a profile with a weakly cemented sand overlain by an uncemented sand and underlain by a karst limestone was studied using 51 reduced-scale, stress-correct centrifuge models. The interaction between the thickness (\iH\d\ic), cohesive strength (\ic), and unit weight (γ\i\dc) of the cemented sand layer; the thickness (\iH\i\ds) and unit weight (γ\d\is) of the uncemented sand overburden; and the diameter (\iD) of the cavity in the underlying karst formation was examined. Collapse of the cemented sand layer into the underlying opening was observed to occur either as a breakthrough plug with steeply inclined sides at an average angle of 61° to the horizontal or as a dome fallout that left behind a stable arch. The type of failure depended on the model geometry, described by \iH\i\dc/\iD. A dimensionless design chart was developed to predict failure, relating \iNγ\d\ic\iH\d\ic/\ic to \iH\i\dc/\iD for configurations without uncemented sand overburden. The overburden pressure over the cavity at collapse was less than the geostatic overburden pressure. The fraction of full geostatic stress decreased with increasing overburden depth relative to the size of the cavity opening and approached an asymptotic value of about 5%.
|
2022-12-18T04:33:57.049Z
|
29,094,700 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/J.1567-1364.2006.00083.X",
"MAG": "1995000105",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The biogenesis of cytochrome c oxidase requires coordination between the nucleus and mitochondria because both these compartments provide the structural subunits of this enzyme. In addition, synthesis, membrane insertion and assembly of the mitochondrially encoded subunits are controlled in a concerted way by numerous nuclear-encoded factors, including Oxa1 and Cox18, which play successive roles in Cox2 assembly in Saccharomyces cerevisiae. These two factors share a weak structural similarity and define two sub-branches of the Oxa1/YidC/Alb3 gene family, whose members facilitate the membrane insertion of various hydrophobic proteins into diverse biological membranes. In this study, we have analyzed a second human and a third fission yeast member of the family. We show, by deletion in the fission yeast genome, as well as expression and functional complementation experiments in both yeasts, that these new genes belong to the COX18 rather than to the OXA1 sub-branch. So far, the fission yeast gene cox18Sp+ is the smallest functional member of this gene family. COX18Hs gives rise to various mRNAs with different coding capacities, and we show that cox18Sp+ and COX18Hs are expressed at a low level and appear to be stringently regulated. This transcriptional control contrasts with the constitutive abundance of the OXA1 mRNAs and might reflect major functional differences between these nevertheless structurally related genes.
|
2022-12-23T02:04:45.118Z
|
217,047,059 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.7202/1059012ar",
"MAG": "3001913570",
"PubMedCentral": null
},
"license": "CCBYNCSA",
"status": "GOLD",
"url": "http://www.erudit.org/fr/revues/sp/2018-sp04510/1059012ar.pdf"
}
|
La nature des contenus documentaires qui circulent aujourd’hui sur le web, tout comme la facon dont ces documents (qu’ils soient numerises ou « natifs-numeriques ») sont diffuses, edites ou encore (re)contextualises, n’ont rien de neutre : elles impliquent une certaine idee du passe qui, sous l’effet des nouvelles technologies et de notre culture numerique, a connu ces dernieres annees de profondes mutations. Matteo Treleani, dans son ouvrage Qu’est-ce que le patrimoine numerique ? (Le bord de l’eau, 2017), s’est donne pour mission de baliser et de comprendre cette nouvelle conception du passe, pour en mesurer les consequences sur nos logiques de production, de transmission et de reception des archives. Dans une perspective semiologique, il dresse un etat des lieux des mutations epistemologiques de la fabrique des archives, invitant a repenser nos pratiques patrimoniales et notre rapport au passe.
|
2022-08-01T02:54:51.593Z
|
250,657,035 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/jimaging8070199",
"MAG": null,
"PubMedCentral": "9320649"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2313-433X/8/7/199/pdf?version=1658375226"
}
|
Cell migration is essential for physiological, pathological and biomedical processes such as, in embryogenesis, wound healing, immune response, cancer metastasis, tumour invasion and inflammation. In light of this, quantifying mechanical properties during the process of cell migration is of great interest in experimental sciences, yet few theoretical approaches in this direction have been studied. In this work, we propose a theoretical and computational approach based on the optimal control of geometric partial differential equations to estimate cell membrane forces associated with cell polarisation during migration. Specifically, cell membrane forces are inferred or estimated by fitting a mathematical model to a sequence of images, allowing us to capture dynamics of the cell migration. Our approach offers a robust and accurate framework to compute geometric mechanical membrane forces associated with cell polarisation during migration and also yields geometric information of independent interest, we illustrate one such example that involves quantifying cell proliferation levels which are associated with cell division, cell fusion or cell death.
|
2022-11-25T00:46:01.225Z
|
13,863,997 |
{
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"ArXiv": null,
"DOI": "10.1002/anie.201503065",
"MAG": "2168693083",
"PubMedCentral": "4648029"
},
"license": "implied-oa",
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc4648029?pdf=render"
}
|
Sequential reactions between a 2,6-diisopropylphenyl-substituted β-diketiminato magnesium n-butyl derivative and P4 allow the highly discriminating synthesis of unusual [nBu2P4]2− and [nBu2P8]2− cluster dianions.
|
2022-12-10T00:11:45.143Z
|
157,836,704 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1075/thr.5",
"MAG": "2618210903",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This volume surveys political satire as a journalistic genre in Iran since the latter days of the Qajar dynasty to the present, thus spanning one century and more. It is an important resource, but it also provides an analysis. Moreover, this volume is a rare effort to answer a question that looks simple but is very complicated: “Why would someone produce satire, knowing that this act might be followed by dangerous consequences?”, and to find out what motivates political satirists. For this aim, nine prominent political satirists have been interviewed: writers and cartoonists, men and women, those who live abroad and those who still live in Iran. The author analyses this data in relation to, among other things, the main theories of humor to provide a descriptive report for each satirist’s motivations as well as the strength of each motivational element in a general comparative context.
|
2022-12-12T07:29:07.969Z
|
181,760,499 |
{
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"ArXiv": null,
"DOI": "10.33258/BIRLE.V2I2.298",
"MAG": "2946122605",
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},
"license": null,
"status": null,
"url": null
}
|
This study discusses about English conversation teaching by pair-work technique for the firts year English majored students. This study uses Classroom Action Research. It can be used to know the improvement of teachers’ activity and students’ ability after a particular technique applied. The research findings denoted that pair-work technique can attract the students’ motivation to take part in language teaching and improve their ability at speaking, It can seen from the improvement of students’ activities from cycle one to cycle two (82,5 % of the students took part in the teaching -learning process or at level 3,3 ,good category to 91,25% or at the level 3,65, good category in cycle two, and the improvement of their scores was 7 students (21,9%) got score 70 up in pre cycle, 29 students (90,6 %) in cycle one and 32 students (100%) in cycle two. It can be stated that the pair-work technique is appropriate to apply in teaching speaking.
|
2022-12-20T14:33:50.379Z
|
112,000,078 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4028/www.scientific.net/AMM.813-814.101",
"MAG": "2240153998",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
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|
The present study deals with the usage of two types of metallic reinforcements namely bronze and steel, one natural reinforcement namely jute and an artificial reinforcement namely glass for preparation of composite laminates. The study investigates the mechanical behaviour of prepared samples and concludes with the selection of best samples. Four composite laminates were prepared by changing the compositions of reinforcements in polyester resin. Tensile, compressive, flexural and impact tests were carried out on the developed samples and it was found that the inclusion of jute and metallic reinforcements improved the compressive and impact strengths of the composite whereas inclusion of jute and glass improved the tensile and flexural strengths of the composite.
|
2022-12-20T23:47:49.622Z
|
24,176,928 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/jmv.23207",
"MAG": "2116996906",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Hepatitis C virus (HCV) genotype 1a is rare in Japanese patients and the clinical characteristics of this genotype remain unclear. The interferon (IFN) sensitivity‐determining region (ISDR) and single‐nucleotide polymorphisms (SNPs) of interleukin‐28B (IL28B) among patients with HCV genotype 1b are associated with IFN response, but associations among patients with genotype 1a are largely unknown. This study investigated the clinical characteristics of genotype 1a and examined whether genomic heterogeneity of the ISDR and SNPs of IL28B among patients with HCV genotype 1a affects response to combination therapy with pegylated‐IFN‐α2b and ribavirin. Subjects comprised 977 patients infected with HCV genotype 1, including 574 men and 412 women (mean age, 55.2 ± 10.6 years). HCV was genotyped by direct sequencing of the 5′‐untranslated region and/or core regions and confirmed by direct sequencing of the NS5A region. HCV genotypes 1a (n = 32) and 1b (n = 945) were detected. Twenty‐three (71.9%) of the 32 patients with genotype 1a were patients with hemophilia who had received imported clotting factors. Prevalence of genotype 1a after excluding patients with hemophilia was thus 0.9%. Of the 23 patients with genotype 1a who completed IFN therapy, 11 (47.8%) were defined as achieving sustained virological response. Factors related to sustained virological response by univariate analysis were IL28B and ISDR. In conclusion, HCV genotype 1a is rare in Japan. The presence of IL28B genotype TT, and more than two mutations, in the ISDR are associated with a good response to IFN therapy in patients with HCV genotype 1a. J. Med. Virol. 84:438–444, 2012. © 2011 Wiley Periodicals, Inc.
|
2022-12-19T16:52:18.684Z
|
1,026,991 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1158/1055-9965.EPI-10-0815",
"MAG": "2164603596",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Background: Sedentary behavior (prolonged sitting or reclining characterized by low energy expenditure) is associated with adverse cardiometabolic profiles and premature cardiovascular mortality. Less is known for cancer risk. The purpose of this review is to evaluate the research on sedentary behavior and cancer, to summarize possible biological pathways that may underlie these associations, and to propose an agenda for future research. Methods: Articles pertaining to sedentary behavior and (a) cancer outcomes and (b) mechanisms that may underlie the associations between sedentary behavior and cancer were retrieved using Ovid and Web of Science databases. Results: The literature review identified 18 articles pertaining to sedentary behavior and cancer risk, or to sedentary behavior and health outcomes in cancer survivors. Ten of these studies found statistically significant, positive associations between sedentary behavior and cancer outcomes. Sedentary behavior was associated with increased colorectal, endometrial, ovarian, and prostate cancer risk; cancer mortality in women; and weight gain in colorectal cancer survivors. The review of the literature on sedentary behavior and biological pathways supported the hypothesized role of adiposity and metabolic dysfunction as mechanisms operant in the association between sedentary behavior and cancer. Conclusions: Sedentary behavior is ubiquitous in contemporary society; its role in relation to cancer risk should be a research priority. Improving conceptualization and measurement of sedentary behavior is necessary to enhance validity of future work. Impact: Reducing sedentary behavior may be a viable new cancer control strategy. Cancer Epidemiol Biomarkers Prev; 19(11); 2691–709. ©2010 AACR.
|
2022-12-29T17:34:57.820Z
|
167,596,257 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1108/S1572-832320140000023015",
"MAG": "2211084903",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Since the end of the cold war, the arms industry has been experiencing a deep structural transformation. The logical consequence of such short-term and structural evolutions is that companies in the arms industry are looking to access markets beyond national borders. Such transformation becomes a policy concern, since the core regulatory framework has been built on a national basis and there are very limited structural and regulatory means for dealing with an international, or even a transnational, industry in such a sensitive activity as weapons development and production. This chapter wonders whether it is possible to qualify such transformation of the arms industry as an internationalisation process and whether it can be compared to the globalisation of commercial activities. It compares what has happened and continues to happen in the arms industry with the globalisation experienced by commercial industries.
|
2022-02-08T18:53:36.466Z
|
95,089,067 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/01496398408060652",
"MAG": "2024374070",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract A correlation formula based on the separation factor is proposed for the mixture concentration in the adsorbed phase of an ideal binary solution in gas-solid adsorption. This formula is shown to apply to two binary systems (viz., 1,3-butadiene and n-butane on cross-linked polystyrene at 25°C, and acetylene and ethane on activated carbon at 25°C) with similar molecular and thermodynamic properties in the two components for each system. Comparison between the calculated and experimental values of the separation factor showed that the assumption of an ideal mixture is justified for each of these two binary systems. Mixture isotherms for the two ideal binary systems are calculated by the proposed correlation formula from the corresponding single-component isotherms. Good agreement between the calculated and experimental mixture isotherm data confirms that a binary system of two components with similar molecular properties (viz., molecular weight, normal boiling point, vapor pressure, number of carbon...
|
2022-02-10T15:54:28.529Z
|
92,241,650 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.11646/zootaxa.2728.1.6",
"MAG": "2911641235",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Three new species are described in the previously monotypic genus Euidothrips of the subfamily Panchaetothripinae: from Bali, E. antennatus n. sp. and E. longicornis n. sp., and from Borneo, E. borneoensis n. sp. An illustrated key is provided to the four species of the genus.
|
2022-02-10T18:10:35.292Z
|
128,768,750 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1306/D4268301-2B26-11D7-8648000102C1865D",
"MAG": "2106872665",
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},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT The middle to upper Proterozoic Penganga Group of the Pranhita-Godavari valley, South India, contains a thick slope-to-basin limestone-shale succession. The limestone, the Chanda Limestone, is well bedded and micritic with several interbeds of slope-related autoclastic debris-flow lime-clast conglomerates in its lower part. The limestone near its base encloses a 30 m thick interval of rhythmically alternating centimeter- to decimeter-thick beds of limestone and dolomitic limestone. The autoclasts of debris-flow conglomerates within the dolomite-bearing sequence shows similar rhythmic repetition of dolomite and limestone. Dolomite crystals range in size from micrite to 225 µm and have planar-s to idiotopic-p fabrics. A dolomitic bed contains 40-45% dolomite. The dolomite content ommonly decreases from the base to the top of a bed with decline in frequency and size of coarse dolomite rhombs. The dolomite is nonstoichiometric (Ca0.54-0.56 Mg0.46-0.44CO3) and has cloudy core with inclusions of micritic calcite and dolomite. The d13CPDB values of limestone and dolomite vary between +2.0 to +3.4 and +3.8 to +4.3, respectively. The d18OPDB values of limestone and dolomite range from -6.0 to -7.6 and +0.4 to -8.7, respectively. Stratigraphic, petrographic, and geochemical studies suggest dolomitization in normal marine pore water during shallow burial diagenesis. Rhythmicity is attributed to recurrent episodes of dolomitization with Mg2+ derived mainly from dissolution of precursor high-magnesium calcite. A mass-balance calculation suggests that 9 mole % MgCO3 in the precursor would provide sufficient Mg2+. Normal grading of dolomite rhombs suggests that upward movement of Mg-enriched pore water dolomitized a thin interval of lime tone wherever the Mg content reached the threshold for dolomitization.
|
2022-08-20T04:58:08.524Z
|
190,539,828 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2174/1573406415666190430125547",
"MAG": "2949574362",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
BACKGROUND
Protein tyrosine phosphatases 1B is considered to be one desirable validated target for therapeutic development of type II diabetes and obesity.
METHOD
A new series of imidazolyl flavonoids as potential protein tyrosine phosphatase inhibitors were synthesized and evaluated.
RESULT
Bioactive results indicated that some synthesized compounds exhibited potent protein phosphatase 1B (PTP1B) inhibitory activities at the micromolar range. Especially, compound 8b showed the best inhibitory activity (IC50 = 1.0 μM) with 15-fold selectivity for PTP1B over the closely related T-cell protein tyrosine phosphatase (TCPTP). Cell viability assays indicated 8b is cell permeable with lower cytotoxicity. Molecular modeling and dynamics studies revealed the reason of selectivity for PTP1B over TCPTP. Quantum chemical studies were carried out on these compounds to understand the structural features essential for activity.
CONCLUSION
Compound 8b should be a potential selective PTP1B inhibitor.
|
2022-09-12T02:34:25.588Z
|
96,927,420 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/00103624.2014.1003646",
"MAG": "2075416139",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The aim of this study was to compare the behavior of residual zinc (Zn) from different synthetic chelates containing the chelating agents EDTA (ethylenediaminetetraacetate acid), HEDTA (hydroxyethyl-ethylenediaminetriacetate acid), and DTPA (diethylenetriaminepentaacetate acid) applied at different rates. This incubation experiment was carried out under two different moisture conditions (60 percent field capacity and waterlogged) and in two different soils from the central region of Spain (Soilacid, Typic Haploxeralf, and Soilcalc, Typic Calcixerept). The potentially available Zn concentration and short-term available Zn were estimated using the DTPA-TEA (diethylenetriaminepentaacetic acid–triethanolamine) and LMWOAs (low-molecular-weight organic acids) methods. In both soils, the amount of water-soluble Zn was estimated under 60 percent field-capacity conditions. Immediately available Zn was estimated under waterlogged conditions. The Zn concentrations depended on the soil type, the experimental time, and the Zn chelate used. Under both moisture conditions, the soil characteristics caused the residual effects of Zn-EDTA in Soilacid and Zn-DTPA-HEDTA-EDTA applied to Soilcalc, to produce the greatest Zn concentrations.
|
2022-08-23T21:38:03.889Z
|
20,784,540 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/JPHOT.2016.2581485",
"MAG": "2428167557",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The light-emitting diode (LED) is the major source of nonlinearity in LED communications, and the nonlinearity needs to be effectively modeled and thereby mitigated through predistortion or postdistortion to avoid degradation of communication performance. A memory polynomial is often used for LED nonlinearity modeling and mitigation in the literature. However, the estimation of memory polynomial coefficients suffers from numerical instability, resulting in inaccurate modeling and poor performance in nonlinearity mitigation. In this paper, we propose an orthogonal polynomial-based nonlinearity modeling and mitigation technique for LED communications with pulse amplitude modulation (PAM) signaling and show that the proposed technique significantly outperforms the conventional memory polynomial-based techniques.
|
2022-11-25T00:41:49.533Z
|
247,373,062 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1332/175982721x16418164636200",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBYNC",
"status": "HYBRID",
"url": "https://bristoluniversitypressdigital.com/downloadpdf/journals/jpsj/30/2/article-p98.pdf"
}
|
Despite its stated protective purpose, the Modern Slavery Act has often fallen short when it comes to ensuring support, facilitating effective remedy, and safeguarding victims of modern slavery. Support services have been repeatedly flagged as insufficient to meet the needs of those recovering from modern slavery. Survivors have faced a ‘cliff-edge’ of support exiting the national referral mechanism, depriving them of access to essential services and leaving them vulnerable to re-trafficking. Decision-making timeframes have far exceeded stated benchmarks, leaving many survivors in limbo for extended periods of time. In addition, victims of modern slavery continue to be detained by immigration authorities and criminalised for actions committed while they were being exploited. Yet, at the same time, increasing numbers of survivors have been identified and supported as a result of the Act and associated care systems. This article explores developments in support for victims of modern slavery in the five years since the passage of the 2015 Act, assessing strengths, shortcomings, attempts to fill the gaps in provision, and where we go from here.
|
2022-12-10T09:10:53.786Z
|
213,243,818 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.31729/jnma.4839",
"MAG": "3006897289",
"PubMedCentral": "7580485"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.jnma.com.np/jnma/index.php/jnma/article/download/4839/3064"
}
|
ABSTRACT The development of health system in Nepal dates back from ancient period to the modern period starting from ayurvedic medicine to today's modern allopathic treatment. With regard to the different rulers in different time period, the number of improvements and changes in the health system of Nepal has been made. Moreover, the health system is further strengthened by the involvement of people and better management of health information and drug supply.
|
2022-12-09T13:29:09.943Z
|
6,078,832 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1044/1092-4388(2012/12-0058)",
"MAG": "1989480572",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
PURPOSE
In this study, the authors assessed the influence of masking level (29% or 71% sentence perception) and test modality on the processing load during language perception as reflected by the pupil response. In addition, the authors administered a delayed cued stimulus recall test to examine whether processing load affected the encoding of the stimuli in memory.
METHOD
Participants performed speech and text reception threshold tests, during which the pupil response was measured. In the cued recall test, the first half of correctly perceived sentences was presented, and participants were asked to complete the sentences. Reading and listening span tests of working memory capacity were presented as well.
RESULTS
Regardless of test modality, the pupil response indicated higher processing load in the 29% condition than in the 71% correct condition. Cued recall was better for the 29% condition.
CONCLUSIONS
The consistent effect of masking level on the pupil response during listening and reading support the validity of the pupil response as a measure of processing load during language perception. The absent relation between pupil response and cued recall may suggest that cued recall is not directly related to processing load, as reflected by the pupil response.
|
2022-12-17T18:30:40.630Z
|
15,749,819 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/MAGNETOCHEMISTRY2020023",
"MAG": "2339932707",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The monometallic pseudo-octahedral complex, [Co(H2O)2(CH3COO)2(C5H5N)2], is shown to exhibit slow magnetic relaxation under an applied field of 1500 Oe. The compound is examined by a combination of experimental and computational techniques in order to elucidate the nature of its electronic structure and slow magnetic relaxation. We demonstrate that any sensible model of the electronic structure must include a proper treatment of the first-order orbital angular momentum, and we find that the slow magnetic relaxation can be well described by a two-phonon Raman process dominating at high temperature, with a temperature independent quantum tunnelling pathway being most efficient at low temperature.
|
2022-12-23T10:45:48.669Z
|
5,912,851 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/TVT.2015.2431742",
"MAG": "2336136854",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The increase in the size and complexity of current cellular networks is complicating their operation and maintenance tasks. While the end-to-end user experience in terms of throughput and latency has been significantly improved, cellular networks have also become more prone to failures. In this context, mobile operators start to concentrate their efforts on creating self-healing networks, i.e., those networks capable of troubleshooting in an automatic way, making the network more reliable and reducing costs. In this paper, an automatic diagnosis system based on unsupervised techniques for Long-Term Evolution (LTE) networks is proposed. In particular, this system is built through an iterative process, using self-organizing maps (SOMs) and Ward's hierarchical method, to guarantee the quality of the solution. Furthermore, to obtain a number of relevant clusters and label them properly from a technical point of view, an approach based on the analysis of the statistical behavior of each cluster is proposed. Moreover, with the aim of increasing the accuracy of the system, a novel adjustment process is presented. It intends to refine the diagnosis solution provided by the traditional SOM according to the so-called silhouette index and the most similar cause on the basis of the minimum Xth percentile of all distances. The effectiveness of the developed diagnosis system is validated using real and simulated LTE data by analyzing its performance and comparing it with reference mechanisms.
|
2022-12-29T16:13:11.606Z
|
235,840,568 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/18824889.2021.1906018",
"MAG": "3157966591",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.tandfonline.com/doi/pdf/10.1080/18824889.2021.1906018?needAccess=true"
}
|
Localization technology is mostly achieved through Global Navigation Satellite Systems (GNSS). However, in mountainous areas where leaves and trees block signals from satellites, getting an appropriate location with GNSS positioning sometimes becomes difficult. In this paper, a localization algorithm based on altitude profiles with angular momentum (yaw rate) profile is proposed. It is a kind of landmark-based localization algorithm in which altitude and angular momentum (yaw rate) profiles are treated as landmarks. The proposed localization algorithm attempts to identify the current positionbymatching altitude andangularmomentum (yaw rate) reference data prepared in advance with altitude and angular momentum (yaw rate) data currently acquired. The effectiveness of the algorithm is presentedwith several experimental results obtained with real data. This paper is an extension to the previous paper presented at the SICE Annual Conference 2020 [Yokota. Localization algorithm based on altitude time series in GNSSdenied environment. In: 2020 Proceedings of the SICE Annual Conference; ChiangMai, Thailand; 2020 Sep 23–26. p. 952–957], in which vehicle localization was carried out by using only altitude profile matching. This paper used both altitude and angular momentum (yaw rate) for sensor fusion to improve the accuracy of the localization. ARTICLE HISTORY Received 28 October 2020 Accepted 7 January 2021
|
2022-09-06T19:05:10.955Z
|
143,919,413 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S0034670500033994",
"MAG": "1985506246",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Within Congress there are a number of forces that push toward decentralization of influence over the substantive legislative product and lack of coordination of the various legislative enterprises that are being conducted simultaneously. Chief among these forces most of the time are the standing committees of the two houses. There are also a few centralizing forces. Chief among these most of the time are the formal party leaders in the House and Senate, especially those of the president's party if the president views himself as a major figure in the legislative process and behaves aggressively in attempting to implement that self-image.
|
2022-09-08T19:24:58.738Z
|
132,331,885 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1201/EBK1420088304-C13",
"MAG": "2479753188",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The Yucatan Peninsula of Mexico is characterized by numerous coastal lagoons, which are important both ecologically and economically. Wastewater discharge, groundwater pumping, and land use changes are modifying both the structure and function of these lagoons. Here, we assess the condition of 10 such lagoons, 5 on the Gulf of Mexico coast and 5 on the Caribbean coast of the peninsula, via multiple measures, including water quality variables, submerged aquatic vegetation, harmful phytoplankton species richness, and degree of eutrophication. Lagoons varied substantially * Corresponding author. Email: jherrera@mda.cinvestav.mx CONTENTS Abstract ..........................................................................................................................................307 13.
|
2022-10-05T14:39:47.266Z
|
155,092,056 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/asia.201900547",
"MAG": "2946761747",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Acetylene and trans-ethylene bridged BIII -subporphyrin dimers were synthesized by cross-coupling reactions of meso-bromo BIII subporphyrin. These dimers display perturbed and red-shifted absorption spectra reaching around 750 nm and fluorescence reaching at around 850 nm with high quantum yields of 0.39 and 0.47, respectively. DFT calculations have revealed that the HOMOs and the LUMOs of both dimers are spread over the two subporphyrin units as an indication of effective conjugation between the two subporphyrin units. The large Stokes shifts and characteristic pico-second time-resolved transient absorption spectra indicated that the S1 -states of the dimers relax with structural changes, which are larger for the trans-ethylene bridged dimer.
|
2022-11-12T18:08:22.824Z
|
20,951,501 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1097/00005053-200104000-00001",
"MAG": "2083797988",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Most twin and adoption studies of conduct problems have demonstrated modest genetic effects but substantial contributions of shared family environment. Conversely, most investigations have shown marked genetic influences but modest contributions of shared family environment in adult antisocial behavior. However, most previous work has focused on male subjects. We obtained retrospective reports of DSM-III-R-defined conduct disorder (CD) and adult antisocial behaviors from a population-based sample of female-female twin pairs. Genetic and environmental contributions to conduct problems and adult antisocial behaviors were examined using polychoric correlation coefficients and univariate structural equation modeling. Statistically significant but modest heritability was observed for conduct problems. A small, statistically nonsignificant contribution of shared family environment to CD behavior was also noted. Adult antisocial symptoms showed modest contributions of both additive genetic and shared family environmental factors. In both childhood and adulthood, the largest influence on antisocial behavior was individual-specific environment. Our findings support the importance of both genetic and environmental factors in antisocial behavior among women as well as the possibility that the relative importance of each set of influences differs by sex in both childhood and adulthood.
|
2022-12-16T16:10:03.735Z
|
5,341,879 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/TWC.2009.080321",
"MAG": "2144425149",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Wireless cellular networks often need to convey the same data to multiple users simultaneously. This kind of transmission is known as physical layer multicasting. Unfortunately, when any user fails to receive the data correctly, the information must be retransmitted to all the users, resulting in a waste of radio resources. Thus, it is important to investigate the outage probability of multicast channels, which is defined as the probability that the smallest maximum achievable rate among all of the users is smaller than a specified transmission rate. In this paper, we consider the use of multiple antenna multicast channels where the transmitter is equipped with Mt antennas and independent data is transmitted on each antenna to K users. Using extreme value theory, we derive a closed form limiting distribution that the exact distribution of the multicasting channel converges to when the number of users K is taken to infinity. From this result, we find upper and lower-bounds on the outage probability. It is shown that for a given outage probability the upper-bound becomes sufficiently tight to approximate the exact outage probability with K such that it converges to the exact one with a speed faster than Theta (K-1/M t). Using this upper-bound, we identify conditions on the transmission rate and the transmit power necessary to maintain constant outage performance as K increases. Specifically, the transmission rate should be decreased as Theta (K-1/M t) or the transmit power should be increased as Theta (K1/M t). This means that the outage performance improves as the number of transmit antennas increases, because spatial diversity can be well exploited. However, this increase in the number of transmit antennas requires a significant cost. To improve the performance without requiring additional cost, we consider a multiple-slot multicasting that transmits the same data over multiple slots and an antenna subset selection scheme that transmits the data over some subset of the transmit antennas. It is shown that the transmission rate of multiple-slot scheme can be increased when the number of slots is carefully chosen and the diversity-multiplexing trade-off is the same as that of K = 1. Also, the gain in the transmission rate from selecting some subset of the transmit antennas is derived.
|
2022-12-18T09:24:12.829Z
|
144,071,169 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/00220671.1975.10884751",
"MAG": "1989252404",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
AbstractThe hypothesis that a motive to avoid success (M-s) exists in high-achieving 7th, 8th, 9th, and 10th grade girls was investigated. Eighty-five black and white Ss responded to verbal TAT-like stimuli. Scores, treated by chi square, supported the hypothesis that the M-s is prevalent in high-achieving girls and is positively correlated with increasing grade level. However, the M-s was not found to be correlated with race.
|
2022-09-15T06:36:04.510Z
|
40,017,940 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1063/1.1488875",
"MAG": "2044972224",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The recent development of new technologies for in vivo three-dimensional mapping of arrhythmias has enabled a better understanding of the richness of intracardiac anatomy and the relationship between anatomy and arrhythmogenesis. In the present manuscript we review two new technologies for in vivo mapping of atrial arrhythmias and explores the degree to which the anatomic complexity they reveal is important in determining the physiology of both focal and macroreentrant atrial tachycardias. These observations highlight the importance of including sufficient anatomic detail in modeling studies aimed at elucidating the pathophysiology of atrial arrhythmias. (c) 2002 American Institute of Physics.
|
2022-12-12T22:36:25.573Z
|
117,597,406 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1086/319645",
"MAG": "1619470924",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
I propose that two previously unidentified lines at 2.199 and 2.287 μm seen in the spectra of planetary nebulae (PNs) are fine-structure transitions of Kr+2 and Se+3. These are the cosmically most abundant elements with Z > 32. The ionic stages and originating energy levels of the observed transitions are expected to be significantly populated under nebular conditions, and these elements—especially the noble gas Kr—are unlikely to be strongly depleted out of the gas phase into grains. Furthermore, their concentrations can be enhanced by s-processing, which occurs in the interiors of the PN progenitor stars. The observed line strengths are consistent with modest (factor of a few) overabundances. In support of the identification of the 2.199 μm line as [Kr III] 3P1-3P2, PNs that display this line also show [Kr III] 1D2-3P2 6828 Å emission. I identify the 2.287 μm line as [Se IV] 2P3/2-2P1/2. These identifications suggest a new range of possibilities for line identifications in the infrared. In addition, the observability of emission lines from n-capture species introduces a novel approach for studying advanced evolutionary stages and nucleosynthesis in the progenitor stars and for more fully delineating the role of PNs as agents of galactic chemical enrichment.
|
2022-12-14T22:58:22.041Z
|
86,632,231 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5897/SRE.9000238",
"MAG": "2104929749",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Vegetable oils have traditionally been applied in food uses, but recent trends suggest their economic usefulness as industrial fluids. Increasing crude oil prices and emphasis on the development of renewable, environmentally friendly industrial fluids have brought vegetable oils to a place of prominence. Biodegradability provides an indication of the persistence of any particular substance in the environment and is the yardstick for assessing the eco friendliness of substances. The superior biodegradation of vegetable oils in comparison with mineral based oils has been demonstrated severally, leaving scientists with the lone challenge of finding economic and safe means to improve their working efficiency in terms of their poor oxidative stability and high pour points.
Keywords: Biodegradability, oxidative stability, environment, eco friendliness, renewable.
|
2022-12-28T20:29:37.650Z
|
225,779,591 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.18041/2322-634x/rcso.2.2019.6281",
"MAG": "3038712798",
"PubMedCentral": null
},
"license": "CCBYNCSA",
"status": "GOLD",
"url": "https://revistas.unilibre.edu.co/index.php/rc_salud_ocupa/article/download/6281/7833"
}
|
Objetivo: Determinar las fases con mayor dificultad de ejecución en el gesto técnico del revés en deportistas de tenis adaptado.
Métodos: Estudio descriptivo transversal. Participaron los 8 deportistas de la Liga Vallecaucana de tenis adaptado. Se evaluó el gesto mediante el análisis del movimiento en tres dimensiones con el sistema de captura de Qualisys y el procesamiento de la información por medio de Visual 3D.
Resultados: Se identificaron seis fases en el gesto técnico del revés determinando con mayor dificultad de ejecución las fases 4 y 6. Fue posible analizar las articulaciones de hombro, codo, muñeca, tronco y cuello, identificando posibles lesiones osteomusculares.
Conclusión: El gesto de revés es el movimiento de mayor riesgo de lesión en el tenis adaptado.
|
2022-07-31T09:21:13.016Z
|
163,715,700 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1086/668289",
"MAG": "2323936828",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Sophia Lee’s immensely popular novel The Recess; or, A Tale of Other Times (1783–85) opens with an ‘‘Advertisement’’ that reflects on the relations between past and present, history and fiction. ‘‘The characters interwoven in this story,’’ Lee asserts, ‘‘agree, in the outline, with history.’’ One of the effects of this and other enigmatic statements—such as her declaration that she possesses an ‘‘inviolable respect for truth’’ (TR , 5)—has been the way it has invited critics to approach the novel as though it were a riddle to be cracked. Thus the question motivating most critical examinations of the novel has been, What is the hidden truth disclosed by Lee’s fiction? Her feminist readers, by and large, have taken the secret truth of The Recess to be that romance or fiction may recuperate the lost, subterranean history of women’s lives. This reading has been remarkably tenacious, cropping up initially in the first reclamations of Lee’s novel in the 1980s and persisting as a founding assumption of later critical examinations. Thus Jane Spencer, one of the novel’s first feminist commentators, contends that Lee’s work ‘‘purports to restore lost records of women’s lives to history . . . by turning history into romance.’’ Along the same lines, Diana Wallace suggests that Lee positions ‘‘The Recess in an established female tradition of writing historiography as fiction,’’ while April Alliston offers a variation on the theme, reading the novel as authorizing ‘‘the fault of rewriting history in the feminine.’’
|
2022-09-08T21:32:16.384Z
|
56,465,427 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1504/IJMASSC.2006.008622",
"MAG": "2138930411",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The main task of mass customisation is the integration of the individual customer's input into the manufacturer's system of value creation. This function can be supported through information technology, such as web-based configurator tools. With such tools customers are enabled to virtually assemble a product. However, customers must also learn to deal with the complexity of the product model and of the configurator tool itself. This work introduces different approaches to overcome the problems of complexity and uncertainty associated with this customer tool interaction. Additionally, the prototype of a web-based configurator tool for products with many degrees of freedom is described from the user's point of view.
|
2022-09-10T11:51:22.178Z
|
252,187,904 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3389/fimmu.2022.980707",
"MAG": null,
"PubMedCentral": "9510589"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.frontiersin.org/articles/10.3389/fimmu.2022.980707/pdf"
}
|
Introduction We previously showed that attenuated glucocorticoid receptor (GR) function in mice (GRdim/dim) aggravates systemic hypotension and impairs organ function during endotoxic shock. Hemorrhagic shock (HS) causes impaired organ perfusion, which leads to tissue hypoxia and inflammation with risk of organ failure. Lung co-morbidities like chronic obstructive pulmonary disease (COPD) can aggravate tissue hypoxia via alveolar hypoxia. The most common cause for COPD is cigarette smoke (CS) exposure. Therefore, we hypothesized that affecting GR function in mice (GRdim/dim) and pre-traumatic CS exposure would further impair hemodynamic stability and organ function after HS. Methods After 3 weeks of CS exposure, anesthetized and mechanically ventilated GRdim/dim and GR+/+ mice underwent pressure-controlled HS for 1h via blood withdrawal (mean arterial pressure (MAP) 35mmHg), followed by 4h of resuscitation with re-transfusion of shed blood, colloid fluid infusion and, if necessary, continuous intravenous norepinephrine. Acid–base status and organ function were assessed together with metabolic pathways. Blood and organs were collected at the end of the experiment for analysis of cytokines, corticosterone level, and mitochondrial respiratory capacity. Data is presented as median and interquartile range. Results Nor CS exposure neither attenuated GR function affected survival. Non-CS GRdim/dim mice had a higher need of norepinephrine to keep target hemodynamics compared to GR+/+ mice. In contrast, after CS exposure norepinephrine need did not differ significantly between GRdim/dim and GR+/+ mice. Non-CS GRdim/dim mice presented with a lower pH and increased blood lactate levels compared to GR+/+ mice, but not CS exposed mice. Also, higher plasma concentrations of some pro-inflammatory cytokines were observed in non-CS GRdim/dim compared to GR+/+ mice, but not in the CS group. With regards to metabolic measurements, CS exposure led to an increased lipolysis in GRdim/dim compared to GR+/+ mice, but not in non-CS exposed animals. Conclusion Whether less metabolic acidosis or increased lipolysis is the reason or the consequence for the trend towards lower catecholamine need in CS exposed GRdim/dim mice warrants further investigation.
|
2022-10-07T00:25:31.260Z
|
57,677,078 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1051/MATECCONF/201824603044",
"MAG": "2904637772",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
: Convolutional Neural Networks (CNNs) have become the most advanced algorithms for deep learning. They are widely used in image processing, object detection and automatic translation. As the demand for CNNs continues to increase, the platforms on which they are deployed continue to expand. As an excellent low-power, high-performance, embedded solution, Digital Signal Processor (DSP) is used frequently in many key areas. This paper attempts to deploy the CNN to Texas Instruments (TI)'s TMS320C6678 multi-core DSP and optimize the main operations (convolution) to accommodate the DSP structure. The efficiency of the improved convolution operation has increased by tens of times.
|
2022-11-25T00:48:21.931Z
|
20,572,681 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.21037/jtd.2016.05.89",
"MAG": "2409667216",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc4958783?pdf=render"
}
|
Concomitant occurrence of atrial myxoma and esophageal carcinoma is an extremely rare entity. Here we present two cases of synchronously suffered left atrial myxoma and esophageal carcinoma. Both patients underwent simultaneous resection of two tumors via the right thoraco-abdominal approach and recovered well.
|
2022-12-14T22:47:12.680Z
|
145,811,631 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1590/S1413-85572006000100004",
"MAG": "2241976780",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
O presente estudo teve como objetivo verificar a alteracao do nivel de Burnout em professores por intermedio da intervencao da tecnica de grupos operativos. A amostra foi composta por professores de 5a a 8a serie de uma escola particular de Porto Alegre, subdividindo-se em dois grupos, o de controle e o experimental, com 12 professores em cada grupo. Para medir a Sindrome de Burnout foi utilizado o MBI (Maslach Burnout Inventory). Apos a primeira aplicacao do teste em todos os professores, realizaram-se 9 encontros sob a tecnica de grupos operativos com o grupo experimental e posteriormente, todos responderam novamente ao teste. Os resultados demonstraram aumento do nivel de Burnout, bem como nas suas dimensoes: esgotamento emocional, realizacao profissional e despersonalizacao para o grupo experimental. Na analise da intervencao constatou-se a importância tanto da sensibilizacao profissional do trabalho docente como do apoio social entre os professores como estrategias para a prevencao e o enfrentamento da Sindrome de Burnout.
|
2022-11-11T08:21:49.028Z
|
168,093,082 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/NVSM.438",
"MAG": "2146774525",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Although volunteer levels are near all-time highs, volunteer coordinators are increasingly spending more time on retention efforts. The purpose of this study is to measure the impact of organizational communication and inclusive behaviors on volunteers' intention to continue volunteering. Through a survey of 472 volunteers in three library systems, research revealed that two organizational communication theories can improve the effectiveness of volunteer coordinator efforts. Specifically, structural equation modeling revealed that social group inclusion and overall participation in organizational events were the strongest predictors of female volunteers' future intentions to volunteer whereas event participation, being included in the organization's information network, and participating in decision making were the strongest predictors for male volunteers. Relationship indicators successfully predicted which volunteers were most likely to continue volunteering. Copyright © 2011 John Wiley & Sons, Ltd.
|
2022-12-26T20:08:52.675Z
|
121,832,412 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1143/JPSJ.40.1209",
"MAG": "2137153447",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The temperature dependence of the EPR frequency is calculated for antiferromagnets with inequivalent g -tensors. Contrary to the previous results for the systems with isotropic g -factor, the EPR frequency increases rapidly for every orientations of the magnetic field as the temperature is reduced. The observed temperature dependence of the resonance fields in several copper salts is discussed by use of this result.
|
2022-08-28T00:52:53.030Z
|
32,952,306 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ISCC.2010.5546529",
"MAG": "2023015128",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The flexibility and self-organization properties of Wireless Mesh Networks (WMNs), and the benefits arising from the split of a physical network in several context-aware Virtual Networks (VNs), are a two-fold force to deal with the huge heterogeneity of user requirements and network resources in a future Internet architecture. In this scope, we provide a novel context-aware architecture for WMNs, which supports user requirements on demand by the deployment of several adaptable VNs for different context-aware purposes. In this paper, we present an analytical model for the proposed architecture. We aim to provide and define the limits of our multi-VN approach, in terms of the number of VNs, attached mesh clients, and virtual nodes per VN, in order to accomplish feasible delays for different data or control communication requirements. Moreover, we describe and evaluate, based on a probabilistic approach, the delays involved in user connectivity establishment, which includes several management processes for the discovery, extension and update of one fitting VN for a user. Through a delay-based approach, our analytical results show the effectiveness of our architecture to deal with different communication requirements, and with distinct scenarios for user connectivity establishment.
|
2022-09-02T12:48:35.530Z
|
5,003,569 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/acs.jpcb.7b05847",
"MAG": "2712231607",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The mobility of aromatic chiral molecules 1-phenylethanol and 1-phenyl-1-propanol in liquids was studied by 1H NMR spectroscopy depending on the strength of the external magnetic field, temperature, and concentration ratio of enantiomers. The data obtained were analyzed using Arrhenius law. The activation parameters were found to depend on the applied field. This effect is caused by the induced magnetic moments in aromatic molecules. The use of strong magnetic fields seems to be promising for investigation of intermolecular interactions of chiral molecules.
|
2022-09-08T19:06:45.957Z
|
236,599,658 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.26843/RENCIMA.V12N3A10",
"MAG": "3160756215",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Os índices aquém do considerado básico para estudantes brasileiros, nas avaliações nacionais e internacionais, apontam para possíveis déficits na aprendizagem de Matemática, inclusive, uma deficiência no ensino de álgebra. Nesse contexto, o artigo apresenta reflexões sobre a álgebra nos anos finais do Ensino Fundamental (EF), a partir dos Parâmetros Curriculares Nacionais (PCN) e da Base Nacional Comum Curricular (BNCC), para construção do pensamento algébrico significativo no cotidiano escolar. Possui uma abordagem qualitativa, desenvolvida por meio de um estudo bibliográfico. Nos PCN, a álgebra compunha um dos conteúdos trabalhados pelo bloco Números e Operações, sendo sua abordagem explícita a partir do 3º ciclo do EF. A Base atribuiu papel de destaque à álgebra, quando a definiu como uma das cinco unidades temáticas da Matemática, propondo trabalhá-la desde o 1º ano do EF, através da construção gradativa de conhecimentos, tirando do 8º ano o compromisso de enfatizá-la massivamente. Diante do exposto, observa-se que a BNCC apresenta uma proposta mais detalhada para álgebra, pautada na dissolução dos conteúdos em todo o EF, na tentativa de promover o desenvolvimento do pensamento algébrico significativo, o que gera expectativas de reorganização curricular como uma das alternativas para melhora no desempenho dos estudantes brasileiros em Matemática.
|
2022-09-09T05:58:32.105Z
|
238,993,399 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.23919/URSIGASS51995.2021.9560606",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Space Metrology is the measurement science conducting technical and management activities to realize the uniformity of measurement units and to ensure the reliability and accuracy of measurement value in extraterrestrial space. Research in Space Metrology aims to meet to needs of on-site calibration for long-life spacecraft and extraterrestrial base such as the Mars base or the lunar base. Integrating Theory of General Relativity into Metrology, research on the theory of metrology in 4-dimensional spacetime is proposed here. This paper provides an overview of the effect of Relativity on definition of SI units and ongoing technical researches in the engineering field.
|
2022-09-29T22:03:24.909Z
|
32,114,710 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1055/s-0042-110555",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In Germany in 5.5% of all births diabetes is registered. In patients with type 1 and type 2 diabetes planning pregnancy, preconception counseling, diabetologic care with optimized periconceptional metabolic control and folic acid supplementation are essential for good pregnancy outcome. Gestational diabetes (GDM) should be diagnosed timely and managed according to existing guidelines. GDM is treated with insulin in approximately 20%. In 1-2% of GDM cases a glucokinase gene mutation is present (MODY 2). Pregnancies after bariatric-metabolic surgery are increasing and show high risks.
|
2022-12-12T12:02:29.638Z
|
149,497,381 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2307/2385560",
"MAG": "2136914549",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
1. The background to army politics 2. The army faces change 3. The changing of the guard: Ugaki comes to power 4. Reduction and modernisation: the Ugaki era 5. The growth of dissidence 6. The Manmo problem and Tayanka's positive solution 7. Jinan and Mukden: the army sets its course in China 8. Conclusion Notes Bibliography Index.
|
2022-12-19T16:22:52.636Z
|
247,631,511 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1145/3517341",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Quantum data communications and networking involve classical hardware and software. Quantum storage is sensitive to environmental disturbances that may have malicious origins. Teleportation and entanglement swapping, two building blocks for the future quantum Internet, rely on secure classical bit communications. When lack of authenticity, integrity, and replay protection may have a high impact, quantum data communications are at risk and need to be protected. Building upon quantum cryptography and random generation of quantum operators, we propose a solution to protect the authenticity, integrity, and replay of quantum data communications. Our solution includes a classical data interface to quantum data cryptography. We describe how classical keying material can be mapped to quantum operators. This enables classical key management techniques for secure quantum data communications.
|
2022-12-24T10:20:50.783Z
|
234,026,319 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.33448/RSD-V10I2.12337",
"MAG": "3128487174",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This study proposes to examine the potential use of Bacillus aryabhattai in pre-sprouted seedlings of sugarcane inoculated with the microorganism when subjected to different regimes of water supply after transplanting. The experiment was laid out in a randomized-block design with a complete 3 × 2 × 5 factorial arrangement, in five replicates. The factors were represented by pre-sprouted seedlings of three sugarcane varieties (IAC 911099, RB 855156 and CTC 20), two seedling types (inoculated and not inoculated with B. aryabhattai) and five frequencies of water supply, which provided the ability of return to 100% soil field capacity, at every 0, 10, 20, 30 and 40 days. Plant mortality, plant height, number of leaves, stalk diameter and number of tillers were evaluated throughout the experimental period. At the end of the study, the shoot dry matter (SDM) and root dry matter (RDM) contents of the plants were measured. The number of leaves on the plant was affected only in isolation, according to the cultivar, without effects of the other studied factors. There was a double interaction effect between the factors of variety and inoculation (V*I) for the variables of SDM, stalk diameter and height; and between frequency and inoculation (F*I) for stalk diameter. There was a triple interaction effect between variety, inoculation and frequency (V*I*F) for the RDM variable. Thus, the use of B. aryabhattai as an inoculant in pre-sprouted seedlings of sugarcane at the time of seedling formation can improve plant development after transplanting depending on the cultivar used, especially in IAC 911099 and RB 855156.
|
2022-03-20T16:57:27.216Z
|
93,629,335 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/J100181A053",
"MAG": "1970654418",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The rate of oxidation of reduced methyl viologen (MV .+ ) by water, catalyzed by colloidal Pt/Al 2 O 3 , is reduced by a factor of ⇒ 5 when D 2 O is used as a solvent rather than H 2 O in the presence of a pH 4.40 acetate buffer.
|
2022-09-10T21:17:52.255Z
|
14,933,428 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/TED.2009.2031001",
"MAG": "2141576097",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
To address the growing demand for low-noise large-area digital-radiography sensors, a unique CMOS active-pixel sensor (APS) technology has been developed. Large-tiled CMOS radiographic panels can compete in performance with passive-pixel arrays, amorphous-silicon thin-film-transistor panels, and phosphor-panel technologies. Although CMOS sensors have become a key technology in low-cost consumer camera products, CMOS APS technology is also suited for manufacture of large-format imagers used to construct radiographic-detector panels. Large-area CMOS radiographic sensors combine a large full well over 3.5 million e- with low read noise less than 300 e- to provide wide dynamic range and improved signal-to-noise ratio under demanding radiographic imaging conditions. With precision-assembly techniques, tiling gaps are minimized to be less than 0.3 pixels to produce fully correctable flat-field images. Applications include nondestructive testing, scientific imaging, security screening, and medical radiography.
|
2022-09-23T01:24:41.973Z
|
218,503,800 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3389/fpubh.2020.00159",
"MAG": "3023916208",
"PubMedCentral": "7218517"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.frontiersin.org/articles/10.3389/fpubh.2020.00159/pdf"
}
|
Aim: The aims of the present study were to develop and validate a psychological resilience scale reflecting the specificity of the Fukushima disaster, and to examine the effects of this scale on mental health. Methods: The Fukushima Resilience Scale was developed based on data obtained from semi-structured interviews with seven people who had lived in the affected area of Fukushima Prefecture at the time of the disaster. The reliability and validity of the scale were then examined in cross-sectional studies conducted on 500 evacuees through an epidemiological mail survey. To examine the effects of the scale and disaster-related factors on the general mental health status of the respondents, a logistic regression analysis was performed using the six-item Kessler psychological distress scale. Results: The newly developed scale consisted of a four-factor structure: “coping with stigma-related issues,” “sharing experiences of the disaster,” “action-oriented approach,” and “sense of support.” Internal consistency coefficients ranged from 0.66 to 0.79. The multivariable logistic regression analysis showed that the only significant association was between “action-oriented approach” (odds ratio = 1.26) and respondents with a K6 score <5 points. Conclusion: The reliability and concurrent validity of the new developed scale in residents of the evacuation area of Fukushima Prefecture were acceptable. A significant association was found between “action-oriented approach” and good mental health among the evacuees, which suggests that this may improve resilience among people affected by the Fukushima disaster.
|
2022-12-21T15:09:31.810Z
|