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255M
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94,578,293 |
{
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"DOI": "10.1063/1.1623945",
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|
Solid-state 27Al NMR spectra under magic-angle spinning of different forms of aluminum tris(quinoline-8-olate) (Alq3) are presented. Alq3 is an organometallic complex of great importance in the context of organic light-emitting diodes. Our results demonstrate a strong difference in the asymmetry of the electric field gradient (EFG) tensor at the aluminum site between the α and the recently discovered δ polymorph of Alq3. While the EFG is nearly planar (η≈1) in the α phase, it is nearly axially symmetric (η≈0) for the δ phase. This result provides strong support to the hypothesis that the δ phase contains the facial isomer of Alq3. While the spectra of both the α and the δ polymorphs exhibit sharp features, highly disordered forms of Alq3 obtained from rapid vapor deposition onto a cold substrate, yield broadened spectra, indicating substantial structural disorder in the local geometry of different Alq3 molecules.
|
2022-12-18T13:36:08.122Z
|
6,902,031 |
{
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"ArXiv": null,
"DOI": "10.1145/2009916.2009920",
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|
Search is generally a means to the end of finishing a task. While the current search engines are useful to users for finding relevant information, they offer little help to users for further digesting and analyzing the overwhelming found information needed for finishing a complex task. In this talk, I will discuss how statistical topic models can be used to help users analyze and digest the found relevant information and turn search results into actionable knowledge needed to complete a task. I will present several general statistical topic models for extracting and analyzing topics and their patterns in text, and show sample applications of such models in tasks such as opinion integration, comparative summarization, contextual topic trend analysis, and event impact analysis. The talk will conclude with a discussion of novel challenges raised in extending a search engine to an analysis engine that can go beyond search to provide more complete support for users to finish their tasks.
|
2022-12-27T16:00:01Z
|
189,006,952 |
{
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"ArXiv": null,
"DOI": "10.26686/NEKE.V1I1.5058",
"MAG": "2913360327",
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},
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"status": null,
"url": null
}
|
"In my view, a translation is the closest possible reading of a text: I think that regardless of how often you read a literary work, or how deeply you study it, you will never be able to experience it as intimately as you will if you set out to translate it. The translator has to weigh every word and every punctuation mark, has to look between the lines for the author’s overt and not so overt intentions. This is a particularly fascinating process when you translate writers who are great literary stylists, such as Chekhov, Machiavelli, or Augustine. Reading between their lines is what interests me the most; that, and trying to recreate their timing and cadences in my English version."
|
2022-02-08T10:02:20.439Z
|
44,030,842 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICCE-Berlin.2015.7391278",
"MAG": "2285747616",
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},
"license": null,
"status": null,
"url": null
}
|
Some of the home automation solutions support user manageable extensions, although with numerous constraints: e.g. requirement for specific controller devices, operating system dependency, or platform specific programming knowledge for development. This approach results in closed policy of home automation systems and excludes independent developers from anticipating in their expansion. This paper provides a concept and implementation that overcomes these constraints by developing extensions using common Web technologies. It offers mechanism for users to configure their system with new functionality, by installing or removing extension modules from system in run-time. Extensions can be accessed and controlled from various personal devices independent from operating system through Web interface. The solution was validated through development and installation of application for smart devices control, based on modern Web technologies. Still, only basic programming knowledge is required for extension development, making it facile to novice developers.
|
2022-02-12T01:37:49.004Z
|
27,452,038 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/anie.201109162",
"MAG": "2147535707",
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},
"license": null,
"status": null,
"url": null
}
|
Chromophore-peptide systems: a study on a series of pentapeptides covalently connected to planar π systems (1 a and 1 b) or to a curved π system (1 c) showed the influence of the concave shape on the efficient chiral transmission at nano- and mesoscales. Control over the hierarchical growth by H bonding, π-π, and solvophobic interactions made possible the efficient generation of electroactive 3D helical fibers.
|
2022-09-07T18:03:31.665Z
|
126,913,676 |
{
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"ArXiv": null,
"DOI": "10.2495/UT020371",
"MAG": "625525212",
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},
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"url": null
}
|
The paper presents a methodology aimed at predicting urban air quality related to traffic through the production of GIS (geographic information system) vulnerability maps. The technique can be used as a decision tool for transportation planners, it can be used for what-if scenarios for preliminary assessment of future transportation strategies, and it can be used to indicate locations susceptible to air pollution due to current traffic where more detailed air quality monitoring measurement may be needed. The technique is quite general and versatile and can be extended to include a large number of variables.
|
2022-02-09T16:06:08.610Z
|
62,602,931 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4028/www.scientific.net/AMR.614-615.1562",
"MAG": "2002856818",
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},
"license": null,
"status": null,
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|
In order to realize the sensor signal acquisition and analysis of data, according to data acquisition system design ideas of the PCI bus, applying to CPLD complex programmable controller and CH365 interface chip and combined with the actual needs of data collection ,designed a kind of low cost, high speed process controller. CPLD realizes data cache control and the control of reading. This design can gather 16 roads analog signals and real-time pulse signal of 8 roads on the same time, which includes a 16-bit digital output channel and a 32-bit counter, could be used in the real-time control.
|
2022-12-12T11:12:11.306Z
|
233,942,662 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.33053/REVINT.V8I1.337",
"MAG": "3135506190",
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}
|
O projeto PIBEX/Unicruz: “Interdisciplinaridade: fio condutor para a promocao e prevencao da saude do escolar do IEE Professor Annes Dias” defende a educacao entre pares, como forma mais propicia de promocao e protecao da saude do escolar. Em marco de 2020, fomos surpreendidos com a pandemia do novo coronavirus, a qual teve uma rapida disseminacao, contagiando o mundo todo. Logo, esta pandemia teve um impacto na realidade de diversos setores mundiais, entre eles, o setor educacional, que atingiu estudantes de todos os niveis de ensino, tornando o sistema educacional remoto, desafiando a todos a trabalhar de forma on-line, devido ao isolamento social. Buscando avaliar a vulnerabilidade dos estudantes com relacao a temas que permeiam o COVID-19 e o afastamento das aulas presenciais, foi elaborado um questionario que foi aplicado por meio do Formulario On-Line Google Forms. Este instrumento de coleta de dados foi muito significativo, pois e necessario repensar e construir acoes de extensao capazes de levar mais promocao e prevencao a saude deste escolar que esta afastado do convivio presencial com a comunidade escolar.
|
2022-12-14T02:37:58.367Z
|
221,601,490 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/cpu.30120",
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"status": null,
"url": null
}
|
Animal study finds high cocaine doses cause ‘autophagy’ in brain cells Health officials call on FDA to put black‐box warnings on benzodiazepines and opioids Benzodiazepine OD deaths more than quadrupled from 1996 to 2013
|
2022-12-16T22:47:47.224Z
|
119,130,209 |
{
"externalids": {
"ACL": null,
"ArXiv": "1712.02755",
"DOI": "10.4310/HHA.2019.V21.N2.A5",
"MAG": "2963392690",
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"url": null
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|
Let ${\mathcal H}_{q}(d)$ be the Iwahori-Hecke algebra for the symmetric group, where $q$ is a primitive $l$th root of unity. In this paper we develop a theory of support varieties which detects natural homological properties such as the complexity of modules. The theory the authors develop has a canonical description in an affine space where computations are tractable. The ideas involve the interplay with the computation of the cohomology ring due to Benson, Erdmann and Mikaelian, the theory of vertices due to Dipper and Du, and branching results for cohomology by Hemmer and Nakano. Calculations of support varieties and vertices are presented for permutation, Young and classes of Specht modules. Furthermore, a discussion of how the authors' results can be extended to other Hecke algebras for other classical groups is presented at the end of the paper.
|
2022-12-18T06:11:31.344Z
|
198,455,267 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1155/2019/7820618",
"MAG": "2954490888",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://doi.org/10.1155/2019/7820618"
}
|
The current expected loss calculations have recently attracted considerable attention in the research on credit risk modeling, impairment provisioning, and financial networks’ stability. A new CDS-based approach to estimate current expected credit loss is proposed for low default portfolios, containing credit exposures to corporate issuers covered by publicly traded CDS contracts. First, a fraction of CDS spread related to a pure default compensation for different CDS maturities is assessed. Our results contrast with previous research. Second, based on the obtained historical weights of the default risk premium, a forward-looking term structure of the probabilities of default implied by the current CDS quotes is derived. The proposed approach covers both investment and noninvestment grade debt. The resulting framework is applied to a sample of corporate bonds. The developed methodology provides a useful tool, on one hand, for credit risk managers and balance-sheet preparers and, on the other hand, for regulators of financial markets as it sheds light on how procyclicality could be avoided in provisions.
|
2022-09-06T23:15:49.596Z
|
233,100,880 |
{
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"ArXiv": null,
"DOI": "10.7498/aps.65.158901",
"MAG": "3032456060",
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},
"license": "CCBY",
"status": "HYBRID",
"url": "https://doi.org/10.7498/aps.65.158901"
}
|
Online social networks, such as Facebook, Twitter and YouTube, play a vital role in information sharing and diffusion, and recently many dynamics models on social networks have been proposed to model information diffusion. However most models are theoretical, their parameters do not come from realistic data and their validity and reliability have not been evaluated empirically. In the paper we first analyze the users' behaviors of reading and reposting microblog in Sina Weibo, a Twitter-like website in China, and find that users' number of fans, the average reposted number of users' microblog, the intensity of users' interaction and the similarity between microblog topics and users' topic interests can significantly influence reposting behavior. Then we propose an information diffusion model Susceptible-Infected-Recovered based on Users' Behaviors (SIRUB) on microblog networks, compute the users' probability of reading microblog in the model according to the probability of their logging on microblog in a day, and obtain the reposting probability utilizing the logistic regression which considers 16 possible factors influencing users' reposting behavior. The 16 factors can be divided into three categories: the characteristics of microblog publishers, microblog text features and social relationship characteristics. We utilize the beginning 2/3 microblog data to obtain model parameters and logistic regression coefficients, and the remaining 1/3 data to examine the validity of the model. The experiments on Sina Weibo network show that the model can predict users' reposting behavior accurately only when it considers both reading and reposting probabilities. F-score which considers precision and recall is used to assess prediction effect of the model. The highest F-score for the prediction of SIRUB model on users' reposting behavior is 0.228 which is much larger than those of classical Susceptible-Infected-Recovered (SIR, F-score=0.039) and Susceptible-Infected-Contacted-Recovered (SICR, F-score=0.037) models. The prediction on the spreading scope of microblog for SIR and SICR models is related with users' number of fans while for SIRUB model not. For SIRUB model the mean and standard deviation of the errors of prediction on spreading scope are smaller than those of SIR and SICR models. These results indicate that users' behaviors of reading and reposting microblog should be appropriately taken in account when modeling information diffusion on microblog networks, and that, in general, the prediction performance of the data-driven SIRUB model proposed in the paper is better than those of SIR and SICR models regardless of the prediction of users' reposting behavior or diffusion scope of microblog.
|
2022-09-12T07:48:13.135Z
|
7,524,839 |
{
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"ArXiv": null,
"DOI": "10.1145/1008992.1009086",
"MAG": "2039595813",
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},
"license": null,
"status": null,
"url": null
}
|
In this poster, we describe a novel session-based search engine, which puts the search in context. The search engine has a number of session-based features including expansion of the current query with user query history and clickthrough data (title and summary of clicked web pages) in the same search session and the session boundary recognition through temporal closeness and probabilistic similarity between query terms. In addition, the search engine visualizes the rank change of web pages as different queries are submitted in the same search session to help the user reformulate the query.
|
2022-12-12T12:49:57.315Z
|
55,294,039 |
{
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"ArXiv": null,
"DOI": "10.1002/eqe.2526",
"MAG": "1963399045",
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},
"license": null,
"status": "GREEN",
"url": "https://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/217227/1/eqe.2526.pdf"
}
|
Dynamic finite element analyses of a four‐story steel building frame modeled as a fine mesh of solid elements are performed using E‐Simulator, which is a parallel finite element analysis software package for precisely simulating collapse behaviors of civil and building structures. E‐Simulator is under development at the National Research Institute for Earth Science and Disaster Prevention (NIED), Japan. A full‐scale shake‐table test for a four‐story frame was conducted using E‐Defense at NIED, which is the largest shaking table in the world. A mesh of the entire structure of a four‐story frame with approximately 19 million degrees of freedom is constructed using solid elements. The density of the mesh is determined by referring to the results of elastic–plastic buckling analyses of a column of the frame using meshes of different densities. Therefore, the analysis model of the frame is well verified. Seismic response analyses under 60, 100, and 115% excitations of the JR Takatori record of the 1995 Hyogoken‐Nanbu earthquake are performed. Note that the simulation does not reproduce the collapse under the 100% excitation of the Takatori record in the E‐Defense test. Therefore, simulations for the 115% case are also performed. The results obtained by E‐Simulator are compared with those obtained by the E‐Defense full‐scale test in order to validate the results obtained by E‐Simulator. The shear forces and interstory drift angles of the first story obtained by the simulation and the test are in good agreement. Both the response of the entire frame and the local deformation as a result of elastic–plastic buckling are simulated simultaneously using E‐Simulator. Copyright © 2014 John Wiley & Sons, Ltd.
|
2023-01-01T19:37:18.582Z
|
96,881,814 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.1021/ED084P504",
"MAG": "2072266042",
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},
"license": null,
"status": null,
"url": null
}
|
A model of a thermodynamic system is described in which particles (representing atoms) interact with one another, the surroundings, and the earth's gravitational field according to the principles of classical mechanics. The system's energy E and internal energy U are defined. The importance is emphasized of the dependence of energy and work on a frame of reference. The changes ?E and ?U during a process are shown to depend on displacements of the particles at the system boundary and on the contact forces exerted on these particles by the surroundings. Formulas in terms of these displacements and forces are derived for the work and heat appearing in the first law of thermodynamics. The work and heat described by these formulas are shown to be quantitative transfers of energy across the system boundary.
|
2022-09-02T06:28:26.847Z
|
77,061,111 |
{
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"ArXiv": null,
"DOI": "10.1097/00007611-198110000-00009",
"MAG": "2400840373",
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},
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"status": null,
"url": null
}
|
: Since first reporting the association of hyperlipoproteinemia with inner ear disease in a study of 300 patients in 1973, I have continued to focus attention on the presence of lipid abnormalities in patients with inner ear dysfunction. With over 1,400 patients now identified with both abnormal lipids and inner ear symptoms, it has become increasingly apparent that most patients seen by otolaryngologists because of Meniere's disease come from that same large population group who are prone to obesity, maturity-onset diabetes, coronary artery disease, and atherosclerosis. These patients share the common problem of being unable to handle refined carbohydrates well. Based on the reports and studies of many authorities, a hyperinsulinism exists in these conditions. These patients are helped by replacing refined carbohydrates with complex carbohydrates having increased fiber. When these conditions can be identified in patients with Meniere's disease, dietary management has been found to be the most effective therapy.
|
2022-09-10T05:47:13.913Z
|
248,136,403 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1155/2022/4834594",
"MAG": null,
"PubMedCentral": "9018185"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://downloads.hindawi.com/journals/jhe/2022/4834594.pdf"
}
|
Objective To compare the application value of dynamic enhanced magnetic resonance imaging (MRI) and ultrasonic diffused optical tomography (DOT) in early diagnosis of breast cancer. Methods The clinical data of 110 female patients with breast diseases treated in our hospital from June 2018 to June 2021 were selected for the retrospective analysis, and the patients were divided into the benign lesion group (n = 50) and breast cancer group (n = 60) according to the pathologic findings. All patients received dynamic enhanced MRI and ultrasonic DOT examinations for the observation of lesion morphology and analysis of relevant parameters, so as to scientifically evaluate the diagnostic value of dynamic enhanced MRI and ultrasonic DOT for early breast cancer. Results The dynamic enhanced MRI examination found that the proportions of irregular shape, increased vascular shadow, obscure boundary, spicule sign, heterogeneous enhancement, etc. of lesion were significantly higher in the breast cancer group than in the benign lesion group (P < 0.05); parameters such as Ktrans, Kep, and Ve were significantly higher in the breast cancer group than in the benign lesion group (P < 0.05); the ultrasonic DOT diagnosis found that the THC value was obviously lower in the benign lesion group than in the breast cancer group (P < 0.05); compared with the pathologic findings, it was believed that combined diagnosis had significantly higher diagnosis accuracy rate, sensitivity, specificity, positive predictive value and negative predictive value than the dynamic enhanced MRI and ultrasonic DOT diagnosis alone (P < 0.05); and after further analyzing the efficacy of the two diagnosis modalities in diagnosing early breast cancer by ROC curves, the result showed combined diagnosis > dynamic enhanced MRI > ultrasonic DOT. Conclusion Both dynamic enhanced MRI and ultrasonic DOT present higher diagnostic value to early breast cancer, of which dynamic enhanced MRI obtains results closer to the pathologic findings and has diagnostic efficacy higher than ultrasonic DOT. But the combination of the two can significantly improve the diagnosis accuracy rate for early breast cancer, presenting higher diagnostic value.
|
2022-10-04T07:23:12.722Z
|
10,476,010 |
{
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"ArXiv": null,
"DOI": "10.4071/1551-4897-2.1.72",
"MAG": "2178770950",
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},
"license": null,
"status": "GREEN",
"url": "https://digitalcommons.calpoly.edu/cgi/viewcontent.cgi?article=1041&context=ime_fac"
}
|
There is an increasing demand in replacing tin-lead (Sn/Pb) solders with lead-free solders in the electronics industry due to health and environmental concern. The European Union recently passed a law to ban the use of lead in electronic products. The ban will go into effect in July of 2006. The Japanese electronics industry has worked to eliminate lead from consumer electronic products for several years. Although currently there are no specific regulations banning lead in electronics devices in the United States, many companies and consortiums are working on lead-free solder initiatives including Intel, Motorola, Agilent Technologies, General Electric, Boeing, NEMI and many others to avoid a commercial disadvantage. The solder joints reliability not only depends on the solder joint alloys, but also on the component metallization and PCB metallization. Reflow profile has significant impact on lead-free solder joint performance also because it influences wetting and microstructure of the solder joint. Majority researchers use temperature cycling for accelerated reliability testing since the solder joint failure mainly comes from thermal stress due to CTE mismatch. A solder joint failure could be caused by crack initiation and growth or by macroscopic solder facture. There are conflicting views of the reliability comparison between lead-free solders and tin-lead solders. This paper first reviews lead-free solder alloys, lead-free component finishes, and lead-free PCB surface finishes. Tin whisker issue is also discussed. Then the lead-free solder joint testing methods are presented; finite element modeling of lead-free solder joint reliability is reviewed; and experimental data comparing lead-free and tin-lead solder joint reliability are summarized. Finally the paper gives perspectives of transitions to a totally leadfree manufacturing.
|
2022-12-13T21:59:27.242Z
|
17,346,717 |
{
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"DOI": "10.20533/LICEJ.2040.2589.2010.0030",
"MAG": "2464840627",
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},
"license": null,
"status": null,
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|
The current study focuses on the organisational problems that Egyptian student teachers of English encounter when they write an English essay. In particular, the current study aims at investigating students’ cohesion and coherence problems in EFL essay writing. A mixed method research design was used including a questionnaire and a semi-structured in-depth interview. Analysis of findings revealed that students encounter some problems in the cohesion and coherence of EFL essay writing. Discussion and implications of these findings are presented.
|
2022-12-18T07:01:49.970Z
|
152,449,017 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1300/J171v03n02_02",
"MAG": "1495648724",
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},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT Though various types of service skills and knowledge have been suggested for inclusion in service training programs that are designed to improve the competence of frontline service providers, there has been no empirical work to investigate the structural relationships among various types of service skill. In this study, a total of twelve types of service skill are identified. A measurement model for service skills is developed accordingly and tested with the use of hotel service. The results of confirmatory factor analysis reveal acceptable model fit, suggesting that these twelve types of service skill can be classified into two categories: technical versus functional. Performance on technical skills is found to have greater impact on service quality.
|
2022-12-17T12:45:27.658Z
|
154,588,846 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1287/MKSC.13.2.177",
"MAG": "2097899517",
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},
"license": null,
"status": null,
"url": null
}
|
This paper gives an example of renting the reputation of another agent to signal quality. We show that in a "maximally" separating equilibrium, manufacturers of high quality products distribute through retailers with strong reputation reputable retailers, while manufacturers of low quality products distribute through retailers with no reputation discounters. In this way, even if high quality manufacturers have no reputation of their own to post as bond, they can signal quality by posting the reputation of the retailers. In equilibrium, reputable retailers never default on their reputation. We also show that it pays the retailers to invest in reputation, as reputable retailers earn profits bounded away from zero under endogenous sequential entry, while the discounters' profits are zero.
|
2022-12-19T17:44:45.898Z
|
213,902,747 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.33910/herzenpsyconf-2019-2-17",
"MAG": "2997430910",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://doi.org/10.33910/herzenpsyconf-2019-2-17"
}
|
Communication in virtual space is one of the significant elements of life in the digital era. We used the analysis of online discussions on content and process of education to reveal the parameters of communication interactions and their connection with the eruption of conflicts and emotional irritation in verbal behaviour. Debates concerning primary professional discussion (the level of vocational school or bachelor's degree) were chosen as the most relevant. This choice is justified by the necessity to study the potential well-being of students enrolled in these types of professional training, create a more appealing image of socially relevant professions, and to overcome the difficulties of designing appropriate educational programmes for these specialisations. The relational situational text analysis tool was used for data processing. In our research we applied the Bailes scheme, which is presented in the SYMLOG system for the analysis of communicational interactions and their parameters, in the context of a small group discussing a certain topic. Based on this system, we have identified three main criteria that can be used for the analysis of on-line communication. These scales are: “submission–dominance”, “irritation–amiability”, “process– orientation or result–orientation”. In addition, we specially considered the parameters of orientation to the conflict or cooperation. The main characteristics of the interaction types were evaluated according to the expert mapping of the discussion texts. The scales of subordination–dominance, as well as the emotional components of communication proved to be of primary importance. In the discussions with the greatest increase of frustration, the ratio of the statements containing irritation to the amicable ones was five to one. Such discussions were more focused on the process of communication itself. At the same time, communication interactions in which the speaker had the dominant position reached 60 per cent of the overall number of interactions within the discussion. The study of the interaction vocabulary enabled to determine the largest number of statements containing hostile and aggressive vocabulary. The complex and more detailed analysis could contribute to further understanding of the dynamics of communication interactions in the course of frustrating online communication.
|
2022-02-08T02:38:26.298Z
|
144,086,073 |
{
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"DOI": "10.1177/000271622612500111",
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}
|
they had on their persons. The robbery was successfully carried out and the robbers got away without leaving a trace. It is a sample case of hundreds, if not thousands, that take place all over the country. As to burglaries and robberies and crimes at night, the useful household flashlight has taken the place of the burglars’ old dark lantern with its smell of oil and sputtering wick and the shutter that had to be opened and closed.
|
2022-02-09T07:09:04.239Z
|
222,234,841 |
{
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"DOI": "10.21608/absb.2012.7212",
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"status": "BRONZE",
"url": "https://absb.journals.ekb.eg/article_7212_a9f7827a7aa05efd70480018bccd964b.pdf"
}
|
The purpose of the present study was to isolate microbial halothermophiles from hyper saline Al- Hamra Lakeat Wadi An Natrun, Egypt. Twenty eight bacterial isolates were obtained and the morphological and physiological properties in addition to enzyme activities were studied. Amongst those isolates, WN.1B.s was selected as the most potent isolate based on growth at high temperature (up to 65oC) and at high salt concentration (up to 34%, near saturation state).A phylogenetic analysis based on 16S rRNA gene sequences indicated that the isolate WN.1B.s had the highest sequence similarity with respect to type strains of Halomonas caseinilytica (97 %), Halomonas elongata (96 %), Halomonas eurihalina (95 %), Halomonas koreensis (95 %) and Halomonas halmophila (95 %).Based on physiological characteristics and16S rRNA sequence analysisthis isolate was identified as Halomonas caseinilyticaWN.1B.s which belonged to bacterial domain, class Gammaproteobacteria, order Oceanospirillales, family Halomonadaceae, Halomonas species. Enzyme screening for strain WN.1B.s showed that, the isolate secrete amylases, lipases, cellulases and pectinase enzymes under harsh conditions that may be useful in different industrial processes.
|
2022-07-04T09:19:03.988Z
|
17,256,293 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/IPTA.2008.4743762",
"MAG": "2540286985",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A novel image registration algorithm that uses two kinds of information is presented: One kind is the shape information of an object and the other kind is the intensity information of a voxel and its neighborhoods consisting of the object. We, first, segment the medical volume data using the Markov random field model and the ICM algorithm and extract the surface region of the object from a segmented volume data. Second, we use the hidden labeling variables and likelihood method to statistically model the intensity distribution of each voxel at the surface region. We adopt the Bernoulli probability model to formulate a prior distribution of the labeling variable for the transformed voxels. The Gaussian mixture model is taken as a probability distribution function for the intensity of the transformed voxel. We use the EM algorithm to get the proper estimators for the parameters of the complete-data log likelihood function. The EM algorithm consists of two steps: the E-step and M-step. In the E-step, we compute the posterior distribution of the labeling variable by taking the expectation for the log-likelihood function. Next, we drive the estimators for all of the parameters by maximizing this function iteratively in the M-step. Then, we define a new registration measure with the Q-function obtained by the EM algorithm. We evaluate the precision of the proposed approach by comparing the registration traces of the Q- function obtained from the original image and its transformed image with respect to x-translation and rotation. The experimental results show that our method has great potential power to register various medical images given by different modalities.
|
2022-09-01T13:32:47.811Z
|
12,458,592 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/pgmj.63.742.629",
"MAG": "2013506064",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://pmj.bmj.com/content/postgradmedj/63/742/629.full.pdf"
}
|
Forty-four Asian immigrants in Birmingham and 44 age- and sex-matched white Caucasians with ulcerative colitis were compared to investigate the existence of any ethnic differences in the pattern of disease. Asian immigrants demonstrated a male preponderance of 2:1, and compared to the matched Caucasians there was a higher incidence of presenting eosinophilia and a milder course of disease, with more patients experiencing only a single initial attack. In spite of this clinical difference, total or subtotal colitis was the commonest pathological type in both white Caucasians and Indians, whereas in Pakistanis localized distal disease predominated. All ethnic groups suffered the same overall complication rate (55%) which is at variance with the experience of low complication rates in India. The age of onset of ulcerative colitis was related to age at immigration with a mean interval of 11 years. Although in some respects Asian immigrants share the disease pattern of the indigenous population, the observed significant differences could be of importance with regard to pathogenesis.
|
2022-11-04T00:38:59.456Z
|
123,184,051 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/NME.1620360207",
"MAG": "2126728393",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this study the free vibration of circumferentially periodic structures has been analysed using the block Lanczos method in a semi complex domain for extracting real natural frequencies and complex mode shapes. The influence of the number of vectors in the block and also the effect of renumbering of nodes, depending on whether they are internal, adjacent or boundary nodes, on the CPU time are studied. The efficiency of the present method is compared with the subspace iteration schemes.
|
2022-12-10T09:08:35.334Z
|
233,174,956 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1126/scitranslmed.abb0319",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The mitophagy inducer urolithin A reverts muscular dystrophies. Mitigating myopathy through mitophagy Mitochondrial dysfunction has been implicated in Duchenne muscular dystrophy (DMD). Luan and colleagues studied the role of mitophagy (mitochondrial autophagy) in muscle stem cells and DMD. Mitophagy was reduced in muscle biopsies from patients with muscular dystrophies and in mouse and worm models of DMD. Urolithin A, a mitophagy activator, up-regulated mitophagy-related genes and improved mitochondrial respiration, muscle stem cell regeneration and muscle function in models of DMD. This demonstrates how enhancing mitophagy could potentially help treat DMD. Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy, and despite advances in genetic and pharmacological disease-modifying treatments, its management remains a major challenge. Mitochondrial dysfunction contributes to DMD, yet the mechanisms by which this occurs remain elusive. Our data in experimental models and patients with DMD show that reduced expression of genes involved in mitochondrial autophagy, or mitophagy, contributes to mitochondrial dysfunction. Mitophagy markers were reduced in skeletal muscle and in muscle stem cells (MuSCs) of a mouse model of DMD. Administration of the mitophagy activator urolithin A (UA) rescued mitophagy in DMD worms and mice and in primary myoblasts from patients with DMD, increased skeletal muscle respiratory capacity, and improved MuSCs’ regenerative ability, resulting in the recovery of muscle function and increased survival in DMD mouse models. These data indicate that restoration of mitophagy alleviates symptoms of DMD and suggest that UA may have potential therapeutic applications for muscular dystrophies.
|
2022-12-30T18:13:39.336Z
|
222,637,300 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3760/CMA.J.ISSN.1001-4497.1998.03.007",
"MAG": "3029260822",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
为提高肺动脉栓塞的诊断和治疗水平,回顾性分析了54例肺动脉栓塞病例.重点分析常见病因、症状、体征及实验室检查结果.本组54例病死率为37%,深静脉血栓形成是肺动脉栓塞发生的主要原因,其发生率为55%,细菌性心内膜炎、手术、外伤、肿瘤、活动量减少是常见诱因.结论:放射性核素肺灌注和通气扫描相结合具有很高的诊断价值,应做为必查项目;及时诊断和治疗可显著降低病死率和病残率.
|
2022-02-08T00:50:15.729Z
|
99,737,154 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5747/CA.2015.V11.N2.A119",
"MAG": "2510794837",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A manutencao e a correta concentracao de ions sao fatores essenciais para a homeostase nos animais. Algumas enfermidades como hipocalcemia, hipoglicemia, diarreia e outras, comumente acometem bovinos, levando a desequilibrios hidroeletroliticos e acido basicos. Como metodo terapeutico para correcao dessas alteracoes realiza-se a fluidoterapia. Esse trabalho tem como intuito avaliar a utilizacao da via intraperitoneal para a administracao de solucoes cristaloides e outros medicamentos, avaliando-a como uma via eficaz e segura para reidratacao e terapeutica dos animais enfermos.
|
2022-07-11T02:02:12.542Z
|
250,815,076 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1088/0964-1726/13/6/008",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Recently, magnetorheological (MR) dampers have emerged as a potential technology to implement semi-active control in structures and vehicle applications in order to efficiently suppress vibration. Perfect understanding about the dynamic characteristics of such dampers is necessary when implementing MR struts in application. One of the important factors to successfully attain desirable control performance is to have a damping force model which can accurately capture the inherent hysteresis behavior of MR dampers. Different models have been proposed to simulate the hysteresis phenomenon in such a kind of damper. The Bouc–Wen model has been extensively used to simulate the hysteresis behavior of MR dampers. However, considerable differences still exist between the simulation and experimental results. In this work, a methodology to find the characteristic parameters of the Bouc–Wen model in the attempt to better characterize the hysteresis phenomenon of MR dampers has been proposed. The methodology takes into consideration the effect of each individual term of the Bouc–Wen model over the hysteretic loop to estimate the appropriate values of the parameters. The Bouc–Wen model in which the new established characteristic parameters have been used has been validated against experimental data and an excellent agreement has been shown between the simulation and experimental results. Moreover, the findings pointed towards the fact that linear or exponential relationships exist between the estimated parameters and the current excitation. Considering this, a new model based on the Bouc–Wen model has been proposed in which the excitation current has been incorporated as a variable. This proposed modified Bouc–Wen model has also been validated against the experimental results and a good correlation has been found.
|
2022-07-30T21:32:56.398Z
|
119,158,942 |
{
"externalids": {
"ACL": null,
"ArXiv": "1610.08990",
"DOI": "10.3847/0004-6256/152/6/194",
"MAG": "2543237853",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://iopscience.iop.org/article/10.3847/0004-6256/152/6/194/pdf"
}
|
We present a photometric and light curve analysis of an eccentric eclipsing binary in the K2 Campaign 0 field, which resides in Sh 2-252E, a young star cluster embedded in an H ii region. We describe a spectroscopic investigation of the three brightest stars in the crowded aperture to identify which is the binary system. We find that none of these stars are components of the eclipsing binary system, which must be one of the fainter nearby stars. These bright cluster members all have remarkable spectra: Sh 2-252a (EPIC 202062176) is a B0.5 V star with razor sharp absorption lines, Sh 2-252b is a Herbig A0 star with disk-like emission lines, and Sh 2-252c is a pre-main-sequence star with very red color.
|
2022-11-18T00:59:27.806Z
|
2,472,990 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1084/JEM.168.4.1505",
"MAG": "2169339624",
"PubMedCentral": "2189070"
},
"license": null,
"status": null,
"url": null
}
|
Dense monolayers of large, adherent macrophages were prepared from the red pulp of mouse spleen. These sinus-lining phagocytes resembled liver Kupffer cells in morphology, as well as expression of F4/80 and class II MHC antigens and receptors for IgG. C3-coated red cells attached at low levels to spleen macrophages, but attachment and endocytosis were enhanced on fibronectin-coated surfaces. The ionophore A23187 induced spleen macrophages to synthesize prostaglandin E2, but like Kupffer cells, spleen macrophages did not synthesize leukotrienes and made relatively small amounts of HETE and 12-hydroxyheptadecanoic acid. Resident spleen macrophages did not produce H2O2, but splenic inflammatory cells, induced by infection of animals with Listeria monocytogenes, actively released H2O2. We conclude that the functional properties of resident, sinusoidal-lining macrophages in liver and spleen are similar to one another but distinct from other pools of phagocytes.
|
2022-12-23T02:23:19.143Z
|
35,309,715 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4108/cs.1.1.e1",
"MAG": "2034217465",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "http://eudl.eu/pdf/10.4108/cs.1.1.e1"
}
|
Received on 01 February 2015, published on 23 February 2015 Copyright © 2015 Mandler and Carrera. licensed to ICST. This is an open access article distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/3.0/), which permits unlimited use, distribution and reproduction in any medium so long as the original work is properly cited. doi: 10.4108/cs.1.1.e1
|
2022-02-12T08:37:44.376Z
|
54,168,428 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.11622/smedj.2018136",
"MAG": "2902672195",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "http://www.smj.org.sg/sites/default/files/SMJ-59-597.pdf"
}
|
Clinical laboratories for in vitro diagnostics are facing pressure to preserve cost control while providing better services through new initiatives. Laboratory automation is a partial answer to this problem, having come a long way from the early days of clinical laboratory testing. The journey and implementation of automation in the Singapore General Hospital's Clinical Biochemistry Laboratory has allowed for sustained performance in the light of increasing workload and service commitments amid an evolving healthcare environment. Key to realising predicted outcomes is the optimisation of workflow processes, reduction of errors, and spatial placement of specimen reception and analytical areas. This paper gives an overview of our experience with automation in the clinical laboratory and its subsequent impact on service standards.
|
2022-12-03T20:42:25.182Z
|
3,467,846 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2334/josnusd.16-0258",
"MAG": "2601618280",
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://www.jstage.jst.go.jp/article/josnusd/59/1/59_16-0258/_pdf"
}
|
To investigate long-term nonsurgical treatment outcomes in patients with generalized aggressive periodontitis (GAgP) and the impact of root abnormalities (RAs) and other patient-level factors in relation to GAgP progression. Patients (n = 64) from a GAgP cohort who completed active nonsurgical periodontal treatment and consented to re-evaluation after 3 to 11 (mean 5.3) years, were enrolled. RAs were identified using radiographs. Periodontal parameters (e.g., probing depths [PDs], and tooth loss [TL]) were investigated. Multivariate analysis was performed to identify factors contributing to TL and bone level alteration (∆BL). After treatment, the mean number of sites with PDs > 5 mm decreased from 54.3 to 17.2. Annual TL was 0.11/patient. Twenty-one patients (32.8%) had >4 teeth with root abnormalities (RA-teeth) and exhibited a higher risk for TL (univariate odds ration [OR] = 3.52, multivariate logistic OR = 6.57). Factors correlated to ∆BL were sites with residual PD > 5 mm (β = -0.400) and observation time (β = -0.210). Nonsurgical treatment provides beneficial outcomes in GAgP patients. Higher incidence of RAs and high prevalence of residual deep pockets have a negative impact on long-term outcomes.
PRACTICAL IMPLICATIONS
in cases of GAgP with residual deep pockets and high incidence of RAs, clinicians must emphasize that long-term outcomes of nonsurgical treatment may be compromised.
|
2022-12-04T00:52:27.223Z
|
200,084,845 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/acsomega.9b01385",
"MAG": "2963385042",
"PubMedCentral": "6682157"
},
"license": "acs-specific: authorchoice/editors choice usage agreement",
"status": "GOLD",
"url": "https://pubs.acs.org/doi/pdf/10.1021/acsomega.9b01385"
}
|
Efficiency of water oxidation catalysts in terms of overpotential, current density, and voltage stability over time with facile methods of their fabrication remains a key challenge in developing competent mechanisms of storing energy in the form of green hydrogen fuels. In this work, a rapid one-step aerosol-assisted chemical vapor deposition (AACVD) method is employed to synthesize amorphous and highly active cobalt–vanadium mixed oxide catalysts (CoVOx) directly over fluorine-doped tin oxide (FTO) substrates. Morphological and structural characterizations made by field emission scanning electron microscopy, X-ray diffraction, energy-dispersive X-ray spectroscopy, and X-ray photoelectron spectroscopy techniques revealed the formation of pure-phase amorphous films with a gradual variation of topography as a function of deposition time. Of these films, the most active film (CoVOx-20) was obtained in 20 min deposition, showing a spongy networking of interwoven nanofibers with a homogeneous distribution of 3–4 nm pores, achieving an overpotential of 308 mV at 10 mA/cm2 current density. A much higher current density of 175 mA/cm2 could be achieved just at 380 mV of overpotential with Tafel slope as low as 62 mV/dec for this whole range while exhibiting long-term stability. Mass activity, electrochemical impedance spectroscopy data, and the estimation of electrochemically active surface area all endorsed this high catalytic performance of CoVOx-20, which is unprecedented for a low-cost, upscalable, and relatively less conductive substrate such as FTO used here. Our findings, thus, not only highlight the benefits of using AACVD in preparing two-dimensional amorphous catalysts but also prove the high efficiency of CoVOx materials thus obtained, as outlined in a plausible reaction mechanism.
|
2022-12-12T03:14:13.369Z
|
29,724,626 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1159/000057420",
"MAG": "2436967741",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Until a few years ago, growth hormone (GH) and insulin-like growth factor-1 (IGF-1) were considered essential only to the control of linear growth, glucose homeostasis, and for the maintenance of skeletal muscle mass. A large body of evidence recently coming from animal and human studies has unequivocally proven that the heart is a target organ for the GH//IGF-1 axis. Specifically GH exerts both direct and indirect cardiovascular actions. Among the direct effects, the ability of GH to trigger cardiac tissue growth plays a pivotal role. Another direct effect is to augment cardiac contractility, independent of myocardial growth. Direct effects of GH also include the improvement of myocardial energetics and mechanical efficiency. Indirect effects of GH on the heart include decreased peripheral vascular resistance (PVR), expansion of blood volume, increased glomerular filtration rate, enhanced respiratory activity, increased skeletal muscle performance, and psychological well-being. Among them, the most consistently found is the decrease of PVR. GH may also raise preload through its sodium-retaining action and its interference with the hormonal system that regulates water and electrolyte metabolism. Particularly important is the effect of GH on skeletal muscle mass and performance. Taking into account that heart failure is characterized by left ventricular dilation, reduced cardiac contractility, and increase of wall stress and peripheral vascular resistance, GH may be beneficial for treatment of heart failure. Animal studies and preliminary human trials have confirmed the validity of the GH approach to the treatment of heart failure. Larger placebo-controlled human studies represent the main focus of future investigations.
|
2022-12-18T23:45:59.349Z
|
15,448,187 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.2514/6.2008-1318",
"MAG": "2156043602",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Wind tunnel tests on a non-rotating, dynamically scaled wind turbine blade equipped with variable trailing edge geometry were carried out. The effectiveness of the system for active load reduction purposes, with the interaction between structural dynamics, aerodynamics and control was tested. The actuation of the adaptive trailing edge was based on a piezoelectric bender actuator. The full aeroservoelastic system was identified based on input and output measurement signals. A feedback controller, using strain signals on the blade root, was designed, tuned and applied on the system in order to minimize root bending moments. The results show remarkable performance in reduction of blade root strains for both open-loop and closed-loop tests. The sensitivity of various design and control parameters are analyzed both in the prescribed cases and in the feedback-controlled system.
|
2022-12-26T19:07:42.344Z
|
120,632,249 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1088/0022-3727/3/2/310",
"MAG": "1965237628",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A phenomenological theory has been developed for non-linear self-modulation of an amplitude modulated electromagnetic wave, propagating in a magnetoplasma along the direction of the magnetic field, taking both the self interaction and mutual interaction of the two modes into account; unlike presently available theories this theory is not restricted to small values of the modulation frequency. It is shown that the ordinary mode of propagation becomes demodulated and the extraordinary mode of propagation becomes over-modulated during its propagation through the medium. Further, the change in modulation depth with the frequency of the wave is gradual for the ordinary mode and resonant for the extraordinary mode (around the gyrofrequency).
|
2022-02-09T21:50:34.285Z
|
237,874,082 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.31602/rjpo.v4i1.4188",
"MAG": "3173370817",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://ojs.uniska-bjm.ac.id/index.php/riyadhohjurnal/article/download/4188/3021"
}
|
ABSTRAK Penelitian ini bertujuan untuk mengetahui seberapa besar minat masyarakat terhadap pencak silat di kabupaten Karawang. Permasalahan dari penelitian ini adalah untuk mengetahui bagaimana masyarakat mengembangkan pencak silat di kabupaten Karawang. Penelitian ini merupakan penelitian deskriptif kualitatif, yang menggambarkan bagaimana minat masyarakat terhadap pencak silat di kabupaten Karawang, subjek dalam penelitian ini adalah 27 perguruan pencak silat yang ada di kabupaten Karawang. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah observasi, wawancara, dan dokumentasi. Teknik analisis data yang digunakan dalam penelitian ini adalah teknik reduksi data, penyajian data dan penarikan kesimpulan. Hasil penelitian menunjukan bahwa minat masyarakat terhadap perkembangan pencak silat sudah cukup banyak, juga dalam pengorganisasian nya sudah baik, selain itu sarana dan prasarana di masing – masing perguruan pencak silat yang kurang lengkap untuk memenuhi proses latihan, oleh karena itu diperlukan edukasi untuk perkembangan pencak silat khususnya di kabupaten Karawang. Kata kunci: Pencak silat, Perkembangan, Karawang.
|
2022-04-08T00:15:29.550Z
|
146,197,048 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2307/1957139",
"MAG": "2206594747",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This study of the role of Islam in politics should prove useful to the layperson or the professor seeking one short book that recounts and explains the major religio-political events that rocked the Islamic world in the late 1970s and early 1980s—for example, the rise and evolution of the Islamic Republic of Iran, the seizure of the Grand Mosque in Mecca, and the assassination of President Sadat. Esposito limits the geographic scope of his study to the Middle East (from Morocco to Pakistan, excluding Afghanistan), and presents it in the form of a chronological narrative. Chapter 1-3 provide the historical background or context of contemporary Islamic politics. They deal successively with the relationship of Islam to politics in early Islamic history, the nature and legacy of the various movements of Islamic revival and reform in the eighteenth and nineteenth centuries, and the role of Islam in the anti-colonial independence movements and nationalist ideologies of the twentieth century. Chapters 4 and 5, comprising half the text, are more current. Chapter 4 discusses the diverse stateand nation-building paths followed by newly independent Muslim countries in the quarter century after World War II. Using case studies of Turkey, Saudi Arabia, Pakistan, Egypt, and Iran, it analyzes the nature and influence of two major Islamic movements, the Muslim Brotherhood and the Jamaat-i-Islami. Chapter 5 explores the sources and expressions of the Islamic resurgence in the 1970s and 1980s through an examination of the use of Islam by both incumbent governments and opposition movements in Libya, Pakistan, Iran, and Egypt. The study concludes with a short chapter that analyzes the problems and prospects of contemporary attempts to establish modern Islamic states and societies. Esposito is a knowledgeable and sympathetic student of Islamic politics. He is sensitive to the staggering socioeconomic problems that have helped to trigger the Islamic resurgence—problems shared by most lessdeveloped, modernizing countries—and he takes seriously and is respectful of the efforts of Muslim thinkers and activists to find culturally appropriate solutions to these problems. These matters are presented from the perspective of the developing countries involved, their histories, and the history of Islam—not from the perspective of international politics and the concerns of American foreign policy. The presentation is straightforward and quite free of jargon.
|
2022-07-31T00:03:09.065Z
|
62,198,594 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1117/12.822925",
"MAG": "2025059013",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Methods to correct for atmospheric degradation of imagery and improve the "seeing" of a telescope are well known in astronomy but, to date, have rarely been applied to more earthly matters such as surveillance. The intrinsically more complicated visual fields, the dominance of low-altitude distortion effects, the requirement to process large volumes of data in near real-time, the inability to pre-select ideal sites and the desirability of ruggedness and portability all combine to pose a significant challenge. Field Programmable Gate Array (FPGA) technology has advanced to the point where modern devices contain hundreds of thousands of logic gates, multiple "hard" processors and multi-gigabit serial communication links. Such devices present an ideal platform to tackle the demands of surveillance image processing. We report a rugged, lightweight system which allows multiple FPGA "modules" to be added together in order to quickly and easily reallocate computing resources. The devices communicate via 2.5Gbps serial links and process image data in a streaming fashion, reducing as much data as possible on-the-fly in order to present a minimised load to storage and/or communication devices. To maximise the benefit of such a system we have devised an open protocol for FPGA-based image processing called "OpenStream". This allows image processing cores to be quickly and easily added into or removed from the data stream and harnesses the benefits of code-reuse and standardisation. It further allows image processing tasks to be easily partitioned across multiple, heterogeneous FPGA domains and permits a designer the flexibility to allocate cores to the most appropriate FPGA. OpenStream is the infrastructure to facilitate rapid, graphical, development of FPGA based image processing algorithms especially when they must be partitioned across multiple FPGAs. Ultimately it will provide a means to automatically allocate and connect resources across FPGA domains in a manner analogous to the way logic synthesis tools allocate and connect resources within an FPGA.
|
2022-09-04T09:13:56.946Z
|
36,821,948 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1103/PHYSREVB.39.1242",
"MAG": "2080634585",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The magnetotransport due to edge states in a two-dimensional (2D) system smaller than the appropriate phase coherence length is considered. For a 2D ``quantum dot'' driven by two narrower leads and a Fermi energy in the edge-states regime, we find Aharonov-Bohm\char21{}type oscillations in both the longitudinal and the Hall conductances. The latter oscillations are superimposed on the quantized value (${e}^{2}$/h) for single-channel leads. The oscillations survive a substantial amount of disorder. Next, the strip geometry is examined and conditions for Hall quantization are formulated. These conditions are far less restrictive than previously published ones.
|
2022-12-19T18:58:58.412Z
|
115,444,497 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2351/1.5056660",
"MAG": "2896184738",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Laser safety testing is performed under the umbrella of the 1ECEE (IEC System for Conformity testing and Certification of Electrical Equipment), a branch of IEC, also Mown as the CB Scheme. Its members include 137 National Certification Bodies (NCBs) from 39 countries. The significant growth of the organization is reflected in the release of over 40 thousand CB certificates and test reports in the year 2005.The Committee of Testing Laboratories (CTL) is the technical branch of the IECEE. The focus of its activity is test specifications, test methods and reproducibility of test results.At its December 2004 meeting, CTL decided to set up an Expert Task Force 11 (ETF 11) for lasers, with the mission to produce a laser test equipment list, laser testing guidelines, and develop a laser proficiency testing program for the participating test laboratories. ETF11 also has the responsibility to develop Decision Sheets concerning the interpretation of IEC60825-1 and IEC60825-2 and to provide support to other ETFs with respect to the laser safety issues.The paper reviews the past work of the CTL concerning the application of laser safety standards as well as the past and proposed agenda of ETF 11.The authors put forward suggestions for improving communication between the CTL and technical committees developing laser standards, IEC TC 76 in particular.Laser safety testing is performed under the umbrella of the 1ECEE (IEC System for Conformity testing and Certification of Electrical Equipment), a branch of IEC, also Mown as the CB Scheme. Its members include 137 National Certification Bodies (NCBs) from 39 countries. The significant growth of the organization is reflected in the release of over 40 thousand CB certificates and test reports in the year 2005.The Committee of Testing Laboratories (CTL) is the technical branch of the IECEE. The focus of its activity is test specifications, test methods and reproducibility of test results.At its December 2004 meeting, CTL decided to set up an Expert Task Force 11 (ETF 11) for lasers, with the mission to produce a laser test equipment list, laser testing guidelines, and develop a laser proficiency testing program for the participating test laboratories. ETF11 also has the responsibility to develop Decision Sheets concerning the interpretation of IEC60825-1 and IEC60825-2 and to provide support to other ETFs wi...
|
2022-01-27T10:11:12.148Z
|
219,861,712 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3877/CMA.J.ISSN.2095-3224.2019.03.014",
"MAG": "3028669033",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
With the development of targeted therapeutics such as Tyrosine Kinase Receptor inhibitors (TKI) Imatinib, the treatment of rare diseases such as gastrointestinal stromal tumors (GIST) is certainly to the extent that there has been no cure for medicine, the drug has become ″drug to disease,″ but the problems of primary and secondary resistance to gastrointestinal stromal tumors and when it is possible to stop the drug are the key to limite the further improvement to fit sefficacy. Heat shock protein90 (HSP90) inhibitor scan by pass tyrosine kinase receptors and directly act on the protective umbrella HSP90 of the down stream signaling molecules, indirectly degrading down stream signaling molecules and disrupting abnormally activated signaling pathways. This inhibits the growth of gastrointestinal stromal tumors. In recent years, HSP90 inhibitors have been used in clinical trials as a third-line treatment for gastrointestinal stromal tumors. With the continuous development and mutual promotion of pharmacology, molecular biology, bioinformatics and other disciplines, application of next-generation sequencing technology such as BEAMing technology, the application prospects of HSP90 inhibitors will gradually become brighter.
Key words:
Colorectal neoplasms; GIST; HSP90 inhibitor; Clinical application; Tyrosine kinase receptor inhibitors (TKI)
|
2022-02-08T01:30:26.434Z
|
5,129,969 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5755/J01.MECH.65.3.14803",
"MAG": "2737960246",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper presents the decision support system (DSS) framework which allows the selection of proper decision applying technologies, facilities and processes located in partner network of mechanical products. The paper is relevant to Lithuanian industry where the major part of producers in manufacturing engineering are concerned with process, production, and product delivery to the customer. DSS framework interface was modelled and programmed using WEB based technologies. The framework computes manufacturing costs of different product machining options that are compared and the most cost efficient choice is selected. The DSS framework was tested by mechanical components-flanges and may be applicable in more complicated manufacturing environments.
|
2022-07-31T10:29:57.719Z
|
40,468,665 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/toxsci/10.4.563",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Potentiation of haloalkane-induced hepatotoxicity by ketones and ketogenic substances is used to illustrate questions that are raised when considering biological interactions involving toxicants. The following characteristics are considered: The effect of the potentiator (ketone or ketogenic agent) on the dose-response characteristics of the haloalkane toxicant; the recovery process of the potentiated tissue injury; dose-response characteristics of the potentiators (minimally effective dosages); correlation of the potentiation with blood levels of the potentiator (threshold concentrations). The relative specificity of the haloalkanes for interaction are discussed, as well as the potentiation of various forms of hepatic injury (acute, chronic, necrogenic, and cholestatic). Enhanced bioactivation of the haloalkane toxicant is a major mechanism of action for the potentiator; other possible contributing mechanisms, however, require consideration. Mixtures of haloalkanes, leading to enhanced liver injury, can also be potentiated by ketones.
|
2022-09-08T09:46:23.617Z
|
145,156,706 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1515/ling.1987.25.4.671",
"MAG": "2076495308",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this paper we argue that all modes of perception are organized into salient and background constituents. We show that this organization is parallel to that of sentences which are divided into a focus constituent and background. We then argue that the process of recognizing these foregrounded constituents is nonmodular (in Fodor's sense) since it is conditioned by features external to each module. We suggest that a single task-specific mechanism is involved in identifying the highlighted constituent in representations of all modular systems. This mechanism belongs to the central system of cognitive functions but applies prior to other central processes which presuppose the foreground-background organization.
|
2022-09-08T05:53:54.274Z
|
135,715,241 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/ADV.21422",
"MAG": "2025907114",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Properties of natural rubber (NR) filled with various fillers, i.e., furnace black (N330), conductive carbon black (XE2-B), and carbon nanotube (CNT) were investigated. Both untreated and sonicated carbon nanotubes were used and designated as U-CNT and S-CNT, respectively. The filler content was varied from 0 to 8 phr. Regardless of the filler type, the increase in the filler content not only results in increased compound viscosity, reduced cure time, and enhanced cross-link density but also leads to the increase in the modulus and hardness of the vulcanizates. For N330 and XE2-B, the tensile strength increases continuously with increasing filler content. However, for both U-CNT and S-CNT, the tensile strength tends to increase with increasing filler content up to 2 phr and decreases noticeably afterward. At any given filler content, the CNTs give the vulcanizates with the highest values of electrical and thermal conductivities, storage modulus, and tan δ, followed by XE2-B and N330, respectively. Results also elucidate that the sonication of CNT without the presence of surfactant prior to mixing could not improve the degree of CNT dispersion, leading to insignificant difference in properties of the U-CNT-filled and S-CNT-filled vulcanizates.
|
2022-10-07T15:23:58.130Z
|
140,980,860 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4000/EPS.5865",
"MAG": "7694261",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Les populations traditionnelles de l'Amazonie bresilienne ont vecu une exclusion sociale historique comme consequence de la marginalite de leur systeme de production : l'extraction de produits de la foret. Cependant, ces populations experimentent aujourd’hui une revalorisation de leur identite a partir de l'elaboration de projets de developpement durable qui leur attribuent le role de « gardiens de la foret », du fait de leurs savoirs traditionnels. Neanmoins, cette reconnaissance entraine paradoxalement des difficultes economiques pour ces populations, qui presentent une forte dependance a l’egard des politiques publiques de protection sociale. Notre cas d’etude porte sur une commune de l’Ile de Marajo, ou les interventions institutionnelles, a travers les politiques publiques, et l´intensification de l´exploitation du fruit de palmiers d’acai (Euterpe oleracea) entraine des changements dans les modes de vie des populations traditionnelles de l´Amazonie. Ces transformations ont aussi un impact sur la capacite de mobilisation sociale de ces communautes.
|
2022-09-04T05:53:02.058Z
|
119,708,245 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S0022112088000539",
"MAG": "1992002554",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this paper experimental measurements of the time-dependent velocity and density perturbations upstream of obstacles towed through linearly stratified fluid are presented. Attention is concentrated on two-dimensional obstacles which generate turbulent separated wakes at Froude numbers, based on velocity and body height, of less than 0.5. The form of the upstream columnar modes is shown to be largely that of first-order unattenuating disturbances, which have little resemblance to the perturbations described by small-obstacle-height theories. For two-dimensional obstacles the disturbances are similar to those found by Wei, Kao & Pao (1975) and it is shown that provided a suitable obstacle drag coefficient is specified, the lowest-order modes (at least) are quantitatively consistent with the results of the Oseen inviscid model. Discussion of some results of similar measurements upstream of three-dimensional obstacles, the importance of towing tank endwalls and the relevance of the Foster & Saffman (1970) theory for the limit of zero Froude number is also included.
|
2022-09-12T22:06:58.133Z
|
248,728,048 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.31489/2021ped4/45-50",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://doi.org/10.31489/2021ped4/45-50"
}
|
The integration of various disciplines and skills in the educational environment today contributes to the enhancement of the learning process at the university and the expansion of the qualification characteristics of the future specialist. Investments in interdisciplinary initiatives in education have increased, but events are often not planned properly, there are not enough tools for organizing integrated training of specialists in accessing the content of training from broader, interdisciplinary points of view. It is necessary to realize the satisfaction of the need for interdisciplinary educational activities and the acquisition of skills of the 21st century by introducing STEAM education that stimulates educational activities in which science, technology, engineering and mathematics (the main components of STEM education) are connected with the arts in a broader sense. The article considers the issue of developing the potential of innovative training of technical specialists through the methodology of STEAM education. The authors proposed a definition of the concept of «STEAM education» in the conditions of training technical personnel, presented the purpose, scientific methods and potential of the project, considered the main directions of development of this process within the framework of personal and foreign research experience on the construction of training programs using the STEAM approach.
|
2022-05-13T16:05:54.863Z
|
234,091,917 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.6060/IVKKT.20216402.6309",
"MAG": "3128946189",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Целью работы явилось исследование влияния бис-(триэтоксисилилпропил)-тетрасульфида (ТЭСПТ), смешанного с техуглеродом N 330 в соотношении 1 : 1, в виде технического продукта OFS 6945 на структуру и свойства резиновых смесей и резин на основе этиленпропиленового каучука марки Vistalon 2504N и кремнекислотного наполнителя (ККН) марки Росил-175, взятого в дозировке 30 мас. ч. на 100 мас. ч. каучука. Содержание ТЭСПТ составляло 0,035; 0,050 и 0,070 ммоль/100 г каучука. Вулканизующая группа включала серу, тиурам, каптакс, белила цинковые и стеарин технический. Резиновые смеси готовили на вальцах Лб 320 160/160. Органосилан вводили в каучук одновременно с Росилом-175. Оценку однородности распределения наполнителя в готовых смесях осуществляли по результатам испытания образцов на виброреометре RPA-2000, вулканизационные характеристики определяли с помощью прибора MDR-2000. Структуру смесей и резин исследовали методом равновесного набухания образцов в толуоле. Показано, что при увеличении содержания ТЭСПТ возрастает доля связанного каучука в трехкомпонентной смеси каучук – наполнитель – органосилан за счет образования межфазных связей, повышается однородность распределения кремнекислотного наполнителя в каучуковой матрице, улучшается обрабатываемость смесей на валковом оборудовании, возрастают скорость сшивания в основном периоде и степень сшивания макромолекул при одном и том же времени вулканизации. Как следствие, улучшаются упруго-прочностные свойства резин, определяемые в статическом режиме испытания, наилучший комплекс которых обеспечивается при содержании органосилана 0,050 ммоль/100 г каучука.
|
2022-10-28T00:25:53.575Z
|
18,907,752 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1183/09031936.00064710",
"MAG": "2139121160",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://erj.ersjournals.com/content/erj/36/3/693.full.pdf"
}
|
To the Editors:
We read with interest the recent publication by Miller and Pedersen 1 on determining the best way of expressing lung function impairment for prediction of mortality. The authors ranked the methods of expressing forced expiratory volume in 1 s (FEV1). It was concluded that the FEV1 quotient (Q) was the best predictor. We believe that this outcome is in need for some nuances. This ranking is, in our view, only suitable when the parameters under investigation are all valid and when based on proper testing. We feel that this is not the case. We will illustrate this via the FEV1 standardised residuals (SR) and focus on the receiver operating curve (ROC) comparison chosen for the ranking.
The authors point at the phenomenon that the number of residual standard deviation (RSD) values an elderly subject can decline is less than that of a younger subject. Based …
|
2022-11-18T00:12:36.059Z
|
8,094,228 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/CSD.2015.10",
"MAG": "2083385463",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A combination of several activities is required to solve a development task, but in the end, developer reports only part of it. It is difficult to understand whether all committed files were changed because of the reason in a given description. Software developers work on multiple tasks at once and often fail to distinguish them with separate commits because of their unknowingness, as well as of limitations of the current tools for source code versioning. Our idea is to address this problem with identification of software developer's activities from a stream of interaction data in real time. We attempt to identify situations when a developer has worked on multiple tasks, to prevent him from tangling them in a single commit, or to aid him to separate certain activities from the task, e.g., Floss refactoring.
|
2022-12-10T19:26:24.479Z
|
93,918,891 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4028/WWW.SCIENTIFIC.NET/AMR.1004-1005.1281",
"MAG": "1964831482",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A novel method for simultaneous determination of ruthenium and zinc in catalysts for hydrogenation of benzene to cyclohexene was established by inductively coupled plasma optical emission spectrometry after sample digestion by high temperature fusion with Na2O2. Such experiment conditions were investigated as the influence of sample digestion methods, fusion time, fusion temperature, the dosage of Na2O2 and interfering ions on the determination. Under the optimized conditions, the limits of detection (LODs) of Ru and Zn for tested solutions were 11 and 13 ng mL-1, respectively. The relative standard deviations (RSDs) for Ru and Zn were 2.01 and 2.35 % (CRu, Zn = 1 mg L-1, n = 7), respectively. The linear ranges of calibration graphs for Ru and Zn were 0.05 ~ 100.00 mg L-1 and 0.04 ~ 50.00 mg L-1, respectively. The proposed method was applied to determine catalyst samples with good recoveries and satisfactory results.
|
2022-01-27T19:42:12.182Z
|
168,964,164 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.12783/dtetr/mdm2016/4931",
"MAG": "2590984598",
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://doi.org/10.12783/dtetr/mdm2016/4931"
}
|
In recent years, more and more secondary battery are used in industry and daily life, nevertheless, extensive use of secondary battery will bring some impact to the environment such as greenhouse effects, soil pollution and water pollution. Only seeing the integral situation of secondary battery in China and implementing the low carbon strategy by the secondary battery enterprises as soon as possible, can we improve the secondary battery’s environmental impact and better realize the sustainable development. In this paper, we research the carbon footprint of lithium ion secondary battery based on PAS2050 ‘Specification for the assessment of the life cycle greenhouse gas emissions of goods and services’ and select a lithium ion battery project with the annual output of 30 million in company A, calculate carbon emissions of every phase, we conclude that main phase of carbon emissions is still production phase and the proportion is extremely large. In the same time, we also describe the production of the lithium ion battery of our country on a macro level and evaluate the enterprise's carbon footprint to improve the environment effectively. In the end, the paper analyzes the existing low carbon policies in our country and put forward some relevant countermeasures for energy conservation and emissions reduction.
|
2022-05-13T00:11:37.396Z
|
122,777,732 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/TPS.2005.845385",
"MAG": "2163035422",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The spatio-temporal variation of infrared (IR) emission images were obtained from a real three dimensional (3-D) discharge space of a surface discharge type, alternating current plasma display panel (ac PDP) cell with the Ne-Xe (4%) 400 torr gas mixture. IR emissions were observed in each period of Address and Display Separation (ADS) driving scheme with ramp initializing waveform using an image intensified charge coupled device (ICCD) camera and the roles of each electrodes were identified.
|
2022-07-10T22:28:15.037Z
|
248,619,694 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.48161/qaj.v2n1a113",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
هەر چەندە سینەما وەک بەشەکێ نوی ژ ئەدەبیات و هونەری، بەلێ بوویە ئێک ژ بەر بەلاڤترین ژانران، کو جیهان هەمی پێڤە مژویل بوویە، نە بتنێ وەک هونەر مایە، بەلکو وەکو پێشەسازی و پێشەسازیەکە هەرە ب رەواج بەلاڤبوویە. ل دەسپێکا خوە بتنێ وەک پارچە ڤیدیو دهاتە دروستکرن پاشی هێدی هێدی پلان و چیڕۆک و سیناریۆ بۆ هاتە دانان، ل ڤێرێ ئەو فلمێ نوکە ئەم د بینین دەستپێکر. هەر چەندە سینەما د گەلەک قوناغاندا دەربازبوویه، ل دەسپێکێ فلمێن رەش و سپی و بێ دەنگ پاشی فلمێن ب دەنگ و پاشی فلمێت رەنگ و رەنگ و ب دەنگ، تا ڕۆژا ئەڤڕۆ کو ببەرزترین کوالیتی و بەشداریا تەکنیکا گەلەک پێشکەڤتی فلم دهێنە چێکرن، بەلێ هندەک تشت دفلمی دا وەکی خوە نە و چ گوهۆڕین ب سەردا نە هاتینە، وەک سیناریۆ، کو بێی سیناریۆ فلم ناهێنە دروست کرن .
ژیدەرێن نڤێسینا سیناریۆیێ گەلەکن ژوان ژى رۆمان، لەورا مە ب فەر زانى ئەم ئەڤێ ڤەکۆلینێ ئەنجامبدەین، ئەڤ ڤەکۆلینە ل ژێر ناڤ و نیشانێن "رۆمان وهك ژێدهرێ سیناریۆ یا فلمان "ئەڤ ڤەکۆلینە هەولدانەکە ژ بۆ دیارکرنا ژێدەرێن نڤێسینا سیناریۆیێ، ب تایبەتى رۆمانێ، ژ بەر کو ژێدەرەکێ سەرەکی یێ نڤێسینا سیناریۆیێ یە. ب سەدان فلم ژ رۆمانا هاتینە دروستکرن، بەلێ ب گۆهرین و ئالاڤێن تایبەت ب فلمسازیێ ڤە. د ئەنجامدا ڤەکۆلین گەهشتییە ئەوێ چەندێ، کو هەر چەندە رۆمان ژێدەرەکێ سەرەکی یێ دروستکرنا فلمایە، بەلێ نە ئێکسەر بەلکو دهێتە گوهرین بۆ سیناریۆیێ پاشی دەرهێنەر وان هەمی ئالاڤا ب هەستێت خوە دکەتە فلم. هەروەسا سیناریۆ و رۆمان و فلم سێ ژانرێن سەرەکی یێن ئەدبیات و هونەری نە، کو هەر یەک ژوان سالۆخدان و سیمایێن خوە یێن تایبەت هەنە. هەر ئێک ب سەرێ خوە ژانرەکێ جودایە، کو دشێن بێی ئێک و دوو جهێ خوە بگرن و کارێ خوە بکەن. هەر ئێکە ژوان تەکنیکێن خوە یێن تایبەت هەنە کو دهێنە بکار ئینان بۆ ئەنجام دانا ئەوان.
|
2022-08-20T11:15:38.496Z
|
19,286,791 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4236/MSCE.2014.22002",
"MAG": "2037687054",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A novel system of fast pyrolysis and vapour quenching was developed
at pilot scale to obtain bio-oil from biomass. The system uses three-stage of interconnected fluidized bed
reactors that continuously circulate silica sand from an internal pyrolysis
reactor to a second external annular reactor for char burning, which generates
most of the heat required by the pyrolysis reactor, and a third sand-preheating
reactor that burns non-condensable pyrolysis gas. The hot vapours, after high
temperature cleaning, are quenched in a flash cooling system. The process generates up to 62% of bio-oil, 25%
of char and 13% of non-condensable gas. The heat requirements for the total
system are provided by
burning part of the char and non-condensable gases generated in the pyrolysis
step and by preheating the fluidizing gas for the pyrolysis reactor.
|
2022-08-25T03:57:58.380Z
|
27,606,126 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/VTCSpring.2015.7145638",
"MAG": "1507216715",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Selected mapping (SLM) is an effective method for addressing high peak-to-average power ratio (PAPR) issues in orthogonal frequency division multiplexing (OFDM) systems. However, the standard SLM approach introduces additional data decoding challenges in the form of side information (SI) transmission and estimation. In general, SI transmission reduces data throughput and SI estimation normally involves computationally complex procedures, which increase design costs. To eliminate the need for both SI transmission and SI estimation, this paper presents an investigation into the PAPR reduction and BER performance of a new technique based on a modified SLM approach. It is shown that the proposed method simplifies data decoding through SI cancellation without SI transmission. Results show that the proposed method produces similar PAPR reduction performance and BER performance as standard SLM based OFDM system, which presumes perfect SI estimation, within a frequency non-selective (flat) fading channel.
|
2022-12-19T18:15:31.136Z
|
241,253,808 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.32629/hwr.v4i2.2739",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBYNC",
"status": "GOLD",
"url": "https://www.hydropower-wr.com/index.php/hwr/article/view/2739/2593"
}
|
本文主要针对自来水供水管理存在的问题及对策展开深入研究,存在问题中,论述了供水规划较不科学、供水调度运行的经济性严重缺失、节水设备的问题较为突出等,然后有针对性地论述了几点完善对策,如制定供水规划方案、提高供水调度运行的经济性、加大供水管理工作力度、完善供水管理部门的管理体系、注重节水管理、提高供水管理人员的素质水平等,促进自来水供水管理工作的顺利进行,给予饮用水安全一定保证,避免自来水在供水管理方面出现问题。
|
2022-01-24T18:24:07.325Z
|
189,336,803 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.26450/JSHSR.256",
"MAG": "2778347578",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This study has been prepared for the evaluation of the internal audit and independent external viewpoints of the employees in the accounting and finance fields in Gaziantep province. Within this scope, a questionnaire containing 26 questions was applied on 228 employees working in the accounting and finance departments of companies. Findings from the questionnaires were analyzed with SPSS v 24.0 package program. As a result of the study, most of the individuals participating in the survey think that the audit activities are the result of an error. In addition, participants were prejudiced in the external audit activities. In this context, it is recommended that both internal audit and external audit activities be well understood and that training on audit activities be carried out to eliminate prejudices.
|
2022-02-08T09:54:13.336Z
|
28,820,507 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/10.30814",
"MAG": "1995769174",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A microcomputer-based systems for analyzing the motion of human platelets and leukocytes at synthetic surfaces from a sequence of video frames on tape is described. The software is designed to provide convenient interaction with an operator to reduce the burden of manual analysis. In addition, the system computes and stores the cell movement data on disk for subsequent statistical analysis. Measurements include the number and nature of cell-to-surface collisions, residence times, and distances traveled.<<ETX>>
|
2022-09-14T09:25:47.266Z
|
12,567,894 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1006/exnr.1996.0018",
"MAG": "2092608132",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Fibroblast growth factor-2 (FGF-2), locally administered in gelfoam to the striatum of mice treated with the neurotoxic drug 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), has restorative and neuroprotective effects on dopaminergic neurons and associated striatal transmitter systems. Most of the beneficial alterations are apparently indirect. FGF-2 must therefore act through a series of cellular and molecular intermediate steps, which have not been explored. We have previously shown that FGF-2 does not significantly affect the astroglial reaction at the time, when the neuroprotective effect of FGF-2 reaches a peak (Day 11). In this study we have investigated the effect of FGF-2 at earlier time points after MPTP treatment. We report now that as early as 6 h after administration of the gelfoam containing either FGF-2 or control protein, FGF-2 immunoreactivity disappears from astroglial nuclei, while appearing in small ramified GFAP- and S-100-negative cells, most likely microglia. At 18 h, numbers and staining intensities of GFAP-ir astroglial cells are greater in FGF-2- than in cytochrome C-treated animals. At this time FGF-2-ir reappears in astroglia nuclei of cytochrome C-treated animals, but remains undetectable in the striatum carrying the FGF-2-containing gelfoam. Ramified GFAP/S-100-negative presumed microglial cells are now intensely ir for FGF-2. Signs of an FGF-2-mediated astrogliotic reaction are very pronounced at 18 h and 2 days, but no longer at 11 days, when the astrogliosis reaction has become equally strong in FGF-2- and cytochrome C-treated striata. Our results suggest that administration of FGF-2 to the MPTP-lesioned striatum has early effects on astro- and presumed microglia cells, notably on the nuclear FGF-2-ir of astrocytes. These changes may be involved in mediating the neuroprotective effects of FGF-2 in the MPTP-model of Parkinsonism.
|
2022-12-10T04:09:44.399Z
|
54,483,821 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1097/MCC.0000000000000576",
"MAG": "2904867303",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
DOI:10.1097/MCC.0000000000000576 It is widely accepted that randomized clinical trials (RCT) provide a high level of scientific evidence. It is undisputable that RCTs have led to great advances in critically ill patient management in general and in patients with acute respiratory failure and the acute respiratory distress syndrome (ARDS) in particular [1–3]. However, RCTs have many limitations and are not exempt of flaws [4]: their sample-size calculations are often ‘optimized’ and the treatment effect overestimated to make study recruitment feasible (thus are actually underpowered); they usually take years from the initial hypothesis to the publication of their results; generally test only one approach versus another; and strict inclusion criteria to obtain a homogeneous population often prevent extrapolation of their results to the global population admitted to intensive care units. Last, examples of RCTs with different or contradictory results when replicated are not infrequent. On the other hand, observational studies have been criticized for their lower internal validity, the impossibility to adjust on unmeasured confounders, and their inability to provide causal inference. Nevertheless, they allow the inclusion of more ‘real life’ populations, focus on a specific subpopulation usually excluded from RCTs and have the practical advantage to be completed in a relatively short time [5]. When it comes to comparative effectiveness research, statistical tools such as propensity score or instrumental variables can markedly improve observational studies design. Taking ARDS as an example, the LUNG SAFE [6] study, an international observational study of patients with hypoxemic respiratory failure and ARDS, provided crucial information such as: underrecognition of the syndrome (how would you enroll patients with ARDS in a RCT when half of the patients meeting the inclusion criteria are not identified?); complexity of treatments choice (early treatment with noninvasive ventilation could be deleterious in patients with PaO2/FiO2 lower than 150 mmHg [7]); importance of the geo-economic variations on management and outcomes (survival was higher in countries with higher gross national income per person [8]); different managements in specific populations such as immunocompromised [9] or a lack of extensive workup when a cause of ARDS was not identified [10].
|
2022-02-11T21:00:51.331Z
|
196,412,936 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.15406/JACCOA.2014.01.00030",
"MAG": "2122805454",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Introduction: During the last ten years, ultrasound (US) guidance has revolutionized regional anesthesia field in many countries. Despite this, its role in central neuroaxial blockade has been underappreciated by anesthesiologists. Ultrasound examination is useful to identify and mark intervertebral levels, needle insertion point for a midline approach and also to estimate needle orientation and depth from skin surface to subarachnoid space. This is especially helpful in difficult cases. In addition, ultrasound identification of the intervertebral levels is more accurate than clinical estimation using the intercristal line. It also increases the success rate of dural puncture on the first needle insertion attempt. In this article, we share our experience in 30 consecutive central neuroaxial blockades guided by previous ultrasound examination. Methods: Thirty consecutive patients scheduled for orthopedic surgery under spinal anesthesia were included in this prospective analysis. Patients were placed in a sitting position. Ultrasound examination for skin markings and measurements was performed. After this was completed, anesthesia residents performed spinal anesthesia following those marks. Data required for analysis was recorded by an independent observer. Results: Mean time of ultrasound examination before spinal block performing was 5.6 minutes. Success rate of dural puncture on the first needle insertion attempt was 75%. In the rest 25%, the median number of needle passes required for success was 1 (1-3). It is important to state that 10% of the patients had previous spine surgery, 10% presented scoliosis with a severe deformity and 20% had BMI of 32 or more. Conclusion: Ultrasound-guided neuraxial blockade is a useful technique, especially for difficult patients. It is associated with a high success rate of dural puncture on the first needle insertion attempt and a reduction in the median number of needle passes required for success, even when spinal anesthesia was performed by in-training physicians.
|
2022-09-08T02:05:17.458Z
|
52,298,561 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1117/12.331360",
"MAG": "1969348159",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Recently developed Scanning Synthetic Aperture Radar (ScanSAR) instruments require new algorithms for the processing stages because the classical approaches to SAR image generation are not well suited to ScanSAR data. Therefore, other techniques must be investigated. Spectral Analysis (SPECAN) is an efficient implementation of chirp de-correlation and it is specially well adapted to ScanSAR bursts of data. It consists of deramping and a spectral analysis stage that can be implemented by several techniques. One of them is Fast Fourier Transform (FFT) that is very efficient but presents some drawbacks concerning pixel spacing. A recently proposed method is the Chirp Z-Transform (CZT) SPECAN that obtains spectrum information at arbitrary positions. CZT can be efficiently implemented by FFTs and mixing operations and it provides the desired flexibility to the user. The main contribution of this study is the analysis of SPECAN techniques for processing ScanSAR data by comparing spectral estimation methods and new multilook strategies. The new CZT-SPECAN technique is compared with the classical SPECAN approach showing its advantages avoiding interpolation steps. The new multilook strategy implemented by SPECAN also reduces the scalloping effect. The results show that the new method is very promising for obtaining fast and simple ScanSAR image generation.
|
2022-09-10T14:50:29.796Z
|
238,686,671 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/jrfm14090397",
"MAG": "3195739431",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/1911-8074/14/9/397/pdf?version=1629869703"
}
|
In this paper, we propose a general mathematical model for analyzing yield data. The data analyzed in this paper come from a characteristic corn field in the upper midwestern United States. We derive expressions for statistical moments from the underlying stochastic model. Consequently, we illustrate how a particular feature variable contributes to the statistical moments (and in effect, the characteristic function) of the target variable (i.e., yield). We also analyze the data with neural network techniques and provide two methods of data analysis. This mathematical model and neural network-based data analysis allow for better understanding of the variability within the data set, which is useful to farm managers attempting to make current and future decisions using the yield data. Lenders and risk management consultants may benefit from the insights of this mathematical model and neural network-based data analysis regarding yield expectations.
|
2022-12-02T11:25:46.055Z
|
19,985,840 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/030089160308900607",
"MAG": "2409014654",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A representative sample of the general population residing in the city of Florence was invited to participate in the local section of the EPIC study with two major aims: i) to carry out a population-based survey on dietary and life-style habits in this urban area of Tuscany, Central Italy; ii) to compare these results with a large series of EPIC volunteers residing in the same municipality in order to evaluate the differences between the two groups. A random sample of 500 residents (250 women) aged 40-64 years, was invited to participate in the study; 362/500 (72.4%) accepted and followed the EPIC protocol. The distribution of selected individual characteristics (including measured weight and height) showed a high prevalence of being overweight in men (52.2%) and obesity in both sexes (17.4% in men and 12.5% in women). A dietary pattern characterized by a high consumption of red meat, processed meats, olive oil and wine emerged in both sexes; the consumption of vegetables and fresh fruit was approximately 200 and 300 g/day, respectively. The estimated mean intakes of macronutrients reflected this pattern, with a high mean intake of total fat and protein. The mean contribution to total caloric intake provided by fat was 30.9% and 33.6% in these randomly sampled men and women, respectively. The results were compared with those of 9,123 Florence residents aged 40-64 years and enrolled as EPIC volunteers. Current smokers and less educated subjects were less represented among male volunteers, who, in general, showed a healthier dietary pattern (more fresh fruit and less spirits). Female volunteers were taller and heavier and consumed more fresh fruit but also more beef and less carbohydrates. Other statistically significant differences emerged, but the absolute values of these differences were usually modest and the two groups appeared remarkably similar. Overall, our results suggest that the large EPIC-Florence cohort was not strictly selected and showed a total caloric intake and a range of dietary variability similar to that of the general population of the same area.
|
2022-12-11T02:20:09.126Z
|
25,107,743 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3928/00989134-20060401-06",
"MAG": "2464665774",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Secondary analysis of cross-sectional data was used to examine gender differences and depression in elderly Taiwanese Americans. There is a paucity of health-related research focused on Asian Americans. This is especially true in the area of mental health. Depression, the most common psychiatric illness in older adults, is under-diagnosed in Asian Americans. A convenience sample of 100 elderly Taiwanese Americans, 47 women and 53 men, was used. Women were older, had higher depressions cores, more physical illness, poorer sleep scores, and less physical activity. Regression analysis indicated that 25% of the variance in depression scores was explained by sleep quality and physical activity.
|
2022-12-16T08:54:00.916Z
|
21,943,013 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1159/000301104",
"MAG": "1997290738",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Background:The application of national guidelines which specify the appropriateness for hysterectomy is believed to lead to improved patient outcomes. However, there was no evidence to support this assumption by outcome data. Goals: To evaluate adherence to guidelines and the validity of the 1997 Swiss guidelines for the appropriateness of hysterectomy based on changes in patients’ functional and psychosocial status. Method: Multicentre study of 370 consecutive cases from 18 public hospitals assessing data on appropriateness and changes in patient status following hysterectomy. Data on appropriateness were obtained before the procedure (n = 286). Changes in patient status following hysterectomy were assessed using an adapted and weighted score. Baseline data were collected up to 8 weeks prior to hysterectomy. Outcome data were obtained 16–32 weeks after surgery (n = 237). Patients for whom appropriateness data were available (n = 286) were categorized into three groups: (1) 214 patients (74.82%) with an indication for hysterectomy, (2) 36 patients (12.58%) classified as having an indication with regard to their preference, and (3) 36 patients (12.58%) classified as not being appropriate for surgery according to national guidelines. Results: In 87% the indication for hysterectomy was judged as appropriate according to the guidelines. The status of all three groups of patients after hysterectomy was found to be significantly improved compared to baseline levels. Patients with an appropriate indication tended to profit more from hysterectomy. Conclusion: The appropriateness rating found may be interpreted as an example of justified use of medical procedural intervention. There was a positive correlation between appropriateness and outcome. The 1997 guidelines still seem to be valid.
|
2022-12-18T13:57:25.411Z
|
207,517,148 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3109/10715761003709802",
"MAG": "2014600874",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract Reactive oxygen species (ROS) are critically important chemical intermediates in biological studies, due to their multiple physiologically essential functions and their often pathologically deleterious effects. Consequently, it is vital that their presence in biological samples has to be quantifiable. However, their high activity, very short life span and extremely low concentrations make ROS measurement a scientifically challenging subject for researchers. One of the widespread methods for ROS detection, based on the oxidation of the non-fluorescent probe 2′,7′-dichlorodihydrofluorescein (DCFH2) to yield the highly fluorescent 2′,7′-dichlorofluorescein (DCF), was developed more than 40 years ago. However, from its initial application, argumentative questions have arisen regarding its action mechanisms, reaction principles and especially its specificity. Herein, the authors attempt to undertake a comprehensive review: to describe the basic characteristics of DCFH2; to discuss the present views of the mechanisms of its fluorescence formation; to summarize the fluorescence formation interferents; to outline its application in biological research; and to underline its advantages and disadvantages in ROS detection as well as for the methodological considerations that arise during analysis.
|
2022-12-20T23:01:38.972Z
|
196,052,744 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.22214/IJRASET.2018.3436",
"MAG": "2809409432",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The main purpose of this paper is to reduce or mitigate interference caused due to different conditions that arise in an heterogeneous networks. The LTE-A uses the concept of HET-NET, which consists of different eNB’s with different service coverages. The heterogeneous network consists of macro, micro, pico and femto together in same geographical region.To provide maximum service coverage,LTE-A uses multihop relay networks,where RS’S are used along with the base stations.Here in this paper SSMCR-site selection with maximum coverage ratio approach is used, which considers the required no. of serving nodes,their types and placement locations in order to obtain maximum service coverage by mitigating the interference.Here the site selection should be in such a way that it should consume less power and provide high datarate by using RS’S to avoid interference between the nodes in the heterogeneous networks.
|
2022-02-08T07:17:55.246Z
|
39,466,090 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/yea.1543",
"MAG": "1977003014",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/yea.1543"
}
|
Two open reading frames, YIL042c (PKP1) and YGL059w, with 25% sequence similarity to human pyruvate dehydrogenase kinases, were shown to have protein kinase activity. Using GFP fusions, it was demonstrated that the proteins localize in discrete submitochondrial regions. Strains with a null mutation in these loci grew poorly on acetate and ethanol as carbon sources. Doubling times increased from ca. 4 h in the wild‐type to > 6 h for the mutants. Growth rates of the mutants could be restored to wild‐type levels by simultaneous disruption of the PDA1 gene, encoding the E1α subunit of the pyruvate dehydrogenase complex. This observation and the pyruvate dehydrogenase activities measured in the mutant strains and the wild‐type grown on glucose or acetate suggest that the slow growth phenotype on C2 carbon sources is caused by a futile cycle in which phosphoenolpyruvate is converted back to acetyl coenzyme A. Copyright © 2007 John Wiley & Sons, Ltd.
|
2022-08-26T23:59:10.631Z
|
95,754,156 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/19443994.2013.787950",
"MAG": "2008509996",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
AbstractIn this study, concentrated iron solution generated by electrocoagulation (EC) process was used for the removal of nutrients from human urine (yellow water). Yellow water was prepared synthetically with major components: nitrogen and phosphorus. As a result of the pH adjustment, nitrogen and phosphorus, which are present in urine, react with electrochemically generated iron solution and then accumulate in the sludge by precipitation. All experiments were done under different pH values for the evaluation of this novel EC nutrient removal process. The effect of the EC treatment on the removal of nutrients was followed by total nitrogen and phosphate measurements and Fourier transform infrared spectroscopy (FTIR). The effects of treatment parameters (pH, iron/phosphate, iron/nitrogen, and iron/nutrient ratios) on the performance of the EC treatment were also examined for the evaluation of applicability of this novel EC method for the treatment of yellow waters. The results show that the pH increase i...
|
2022-08-24T00:06:05.841Z
|
56,905,497 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1098/rsbm.2004.0009",
"MAG": "2032454999",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
William Donald Hamilton was born in 1936 in Cairo to New Zealander parents, and was brought up for the most part in a rural and wooded part of Kent, England. He described his childhood as idyllic, full of freedom to roam, and of maternal inspiration and encouragement, and himself as a great burrower. He was fascinated by insects from an early age. A great–aunt gave him her insect collection, whose cases he used for his own (later rueing his discarding of the insects themselves), and also lent him a translation from Fabre, the great French naturalist and one of the first to study behaviour scientifically. A birthday present from his parents was a much coveted copy of E. B. Ford's Butterflies (Ford 1945) in Collins's New Naturalist Series, which introduced the 12–year–old to genetics, to a scientific sensibility that looked down on ‘mere collecting’, to mathematical biology in the shape of Mendelian segregation ratios, and to the modern study of evolution. After reading Ford, he asked for a copy of Darwin's Origin of Species as a school prize. To have inspired this one young biologist would by itself justify Ford's efforts in writing Butterflies.
|
2022-09-12T11:13:58.343Z
|
85,929,255 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1656/1528-7092(2003)002[0327:TDOSRI]2.0.CO;2",
"MAG": "2177826566",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract We re-evaluate the distribution of the swamp rabbit (Sylvilagus aquaticus) in Southeast Missouri. We developed a list of 276 sites that were identified by the Missouri Department of Conservation as potential swamp rabbit habitat. Most of these sites were surveyed initially in 1992. We visited 245 of these sites in an effort to establish the presence or absence of swamp rabbits. Presence of swamp rabbits was based on scat deposition on down logs or stumps, presence of skulls or carcasses, sightings of live swamp rabbits, reports by trappers, or kills made by hunters. Logistic regression analysis was used to quantify the relationship between site area and likelihood of swamp rabbit presence. A patch size of approximately 48.6 ha was required to ensure a 50% likelihood of swamp rabbits in 1992, whereas in 2001 only 40.5 ha were required. No significant improvement in the distribution of swamp rabbits has occurred in Missouri since 1992.
|
2022-09-14T06:13:13.731Z
|
21,035,156 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1345/aph.10316",
"MAG": "2109780202",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
OBJECTIVE: To review the use of octreotide for acute variceal bleeding. DATA SOURCES: Articles were obtained through computerized searches involving MEDLINE (from 1997 to October 2000). Additionally, several textbooks containing information on the diagnosis and management of acute variceal bleeding were reviewed. The bibliographies of retrieved publications and textbooks were reviewed for additional references. STUDY SELECTION: All randomized studies and pharmacoeconomic evaluations that used octreotide therapy for acute variceal bleeding were considered. Randomized controlled trials and meta-analyses involving other therapies for treating variceal bleeding were also reviewed for possible inclusion. DATA EXTRACTION: The primary outcomes extracted from the literature were persistent or recurrent bleeding, need for endoscopic intervention or balloon tamponade, and mortality. DATA SYNTHESIS: Although both endoscopic therapies and medications are used to control bleeding and rebleeding episodes, the endoscopic approach has the additional goal of obliterating the varix. Since rebleeding episodes are common as long as the varix is present, endoscopic and medication therapies cannot be considered interchangeable based on bleeding control alone. However, octreotide by continuous intravenous infusion has demonstrated effectiveness in reducing blood loss and transfusion requirements as both an initial intervention (until definitive sclerotherapy can be performed) or as adjunctive therapy to endoscopic measures. Octreotide can be started quickly, has a relatively rapid onset of action, and does not require someone with endoscopy training to initiate. Additionally, octreotide is relatively free of significant adverse effects. CONCLUSIONS: While additional investigations are needed, particularly in the area of pharmacoeconomics, there is substantial evidence that octreotide is an efficacious therapy with relatively few adverse effects when used in the management of acute variceal bleeding.
|
2022-09-15T05:54:23.309Z
|
250,400,089 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/fishes7040165",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2410-3888/7/4/165/pdf?version=1657263014"
}
|
2,4-Dichlorophenoxyacetic acid (2,4-D) is commonly used to control invasive aquatic macrophytes, including Eurasian watermilfoil (Myriophyllum spicatum) (EWM). Potential influences of 2,4-D on non-target organisms are poorly understood; however, research has suggested the possibility of lethal effects on certain fish species. Lake Ellwood, Wisconsin was treated with 2,4-D to control EWM annually during 2003–2012. Fish surveys following treatment revealed natural recruitment failures of several regionally thriving species, including largemouth bass (Micropterus salmoides) and bluegill (Lepomis macrochirus). We hypothesized that these species had been negatively influenced by the chemical treatments. We monitored the post-chemical treatment fish community and aquatic ecosystem for responses during 2013–2019. Similar data were collected from Cosgrove (EWM absent) and Seidel lakes (EWM present, no chemical treatment) as reference systems. Limnological and submersed aquatic vegetation conditions did not change on Lake Ellwood post-chemical treatment. Total zooplankton density increased immediately post-chemical treatment on Lake Ellwood and then stabilized, whereas total zooplankton density did not change on the reference lakes over time. Analyses indicated immediate increases in recruitment post-chemical treatment for largemouth bass, smallmouth bass (Micropterus dolomieu), bluegill, and yellow perch (Perca flavescens). Back calculation of year class strength confirmed failures occurred during treatment for northern pike (Esox lucius), largemouth bass, bluegill, and black crappie (Pomoxis nigromaculatus). Our results provide evidence to suggest long-term 2,4-D treatments may negatively influence fish through lethal and sublethal mechanisms. Thus, there remains a critical need for directed research on whole-lake herbicide treatment side-effects.
|
2022-09-16T06:00:57.256Z
|
122,943,730 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1143/PTP.46.198",
"MAG": "2089114702",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We discuss the relation of the electromagnetic currents of the hadrons to the vector part of the neutral weak currents of the hadrons. We assume these two currents to be the same and conclude from this that the possible existence of the isotensor electromagnetic currents which have been investigated by several authors in recent years is directly related to the possible existence of IJII =2 weak processes or to the possible existence of mesons with isospin 2. This assumption leads to an "extended" C.V.C. in the sense that the isospin relation between the electromagnetic and weak currents is not limited to the isovector but extended to the isoscalar and isotensor.
|
2022-11-18T01:16:12.731Z
|
221,105,036 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/026119299702500506",
"MAG": "2326904879",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
An ECVAM task force on nephrotoxicity has been established to advise, in particular, on the follow-up to recommendations made in the ECVAM workshop report on nephrotoxicity testing in vitro. Since this workshop was held, in 1994, there have been several improvements in the techniques used. For example, the duration of renal slice viability, and the maintenance of functional activities in slices, have been improved by using dynamic incubation systems with higher oxygen tensions and more-appropriate cell culture media. Highly differentiated primary cultures of pig, human and rabbit proximal tubule cells have been established by using specific cell isolation procedures and/or selective culture media. To date, the most comparable phenotypic expression and transepithelial transport capacities to proximal tubules in vivo have been obtained with primary cultures of rabbit proximal tubule cells which are grown on bicompartmental supports; in this system, transepithelial substrate gradients are generated and the transepithelial transport of both organic anions and cations is highly active. This in vitro system has been selected by ECVAM for further evaluation and prevalidation. Industrial needs in the area of nephrotoxicity testing have been identified, and recommendations are made at the end of this report concerning possible future initiatives.
|
2022-12-12T17:46:12.227Z
|
214,723,421 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1101/2020.03.16.994152",
"MAG": "3012333977",
"PubMedCentral": null
},
"license": "CCBYNCND",
"status": "GREEN",
"url": "https://www.biorxiv.org/content/biorxiv/early/2020/03/18/2020.03.16.994152.full.pdf"
}
|
Pandemic coronavirus disease 2019 (COVID-19) is caused by the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), for which there are no efficacious vaccines or therapeutics that are urgently needed. We expressed three versions of spike (S) proteins—receptor binding domain (RBD), S1 subunit and S ectodomain—in insect cells. RBD appears monomer in solutions, whereas S1 and S associate into homotrimer with substantial glycosylation. The three proteins confer excellent antigenicity with six convalescent COVID-19 patient sera. Cryo-electron microscopy (cryo-EM) analyses indicate that the SARS-CoV-2 S trimer dominate in a unique conformation distinguished from the classic prefusion conformation of coronaviruses by the upper S1 region at lower position ~15 Å proximal to viral membrane. Such conformation is proposed as an early prefusion state for the SARS-CoV-2 spike that may broaden the knowledge of coronavirus and facilitate vaccine development.
|
2022-12-16T10:18:25.806Z
|
15,132,026 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1155/2014/241946",
"MAG": "2114947152",
"PubMedCentral": "4897515"
},
"license": "CCBY",
"status": "GOLD",
"url": "http://downloads.hindawi.com/archive/2014/241946.pdf"
}
|
The anti-implantation potential of different fractions of Vitex negundo Linn leaf extract was evaluated in female Swiss Albino mice. Animals from different groups were dosed orally either with 0.2% agar (vehicle) or with fractions of V. negundo leaf extract (n-hexane, chloroform, n-butanol, and remnant fractions) at 10:00 a.m., from day 1 to day 6 of pregnancy. The pregnant females from each group were sacrificed on different days of pregnancy (n = 6), and uterus was excised and used for estimation of lipid peroxidation and assay of superoxide dismutase activity as a marker for blastocyst implantation. Animals treated with n-hexane fraction showed altered level of superoxide anion radical and superoxide dismutase activity as compared to control animals. The probable mechanism by which this extract exhibits inhibition of blastocyst implantation is through the anti-inflammatory and antiestrogenic potential.
|
2022-12-19T09:34:32.468Z
|
31,765,255 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1346-8138.2007.00401.x",
"MAG": "1513778509",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Dear Editor, Interferon (IFN)-γ induces the expression of major histocompatibility complex (MHC) class I and II, intercellular adhesion molecule (ICAM)-1 and human leukocyte antigen (HLA)-DR on the hair epithelium and dermal papilla in alopecia areata (AA), causing the collapse and restoration of MHC class Idependent immune privilege of the hair follicles. On the other hand, degranulating mast cells are observed adjacent to affected hair follicles in AA and further histamine enhances the IFN-γ-induced expression of ICAM-1 and MHC class I on keratinocytes. Collectively, antihistamines are expected to be effective for AA treatment. Although, the guidelines for management of alopecia areata from the British Association of Dermatologists does not include antihistamine therapy, the efficacy of antihistamines for AA has been reported in Japan. In our first case, a 22-year-old woman had suffered from alopecia universalis from the age of 11 years (Fig. 1A). She had a past history of atopic dermatitis in childhood. Topical immunotherapy with diphenylcyclopropenone (DPCP; 0.005–0.1% in acetone) had been continued intermittently for 9 years with only a subtle transient effect. Then, 10 mg/day ebastine, an antihistamine, was administered for 4 months. However, no significant effect was observed (Fig. 1B). We changed the antihistamine to 120 mg/day fexofenadine and hair regrowth started thereafter (Fig. 1C–E), resulting in satisfactory improvement of the hair loss in scalp and eyebrows 10 months later, although for her eyebrows she used tattoos for cosmetic purpose (Fig. 1F). After the administration of antihistamines, DPCP therapy was maintained using the same concentration at 0.01%. In our second case, a 68-year-old woman had suffered from AA with severe hair loss for 2 years (Fig. 2A). We started topical immunotherapy with DPCP (0.0001–0.01%) weekly or biweekly and oral administration of 6 mg/day cepharanthine. Four months later, severe contact dermatitis occurred by DPCP and therefore its concentration was decreased to 0.00025%. A further 1 month later, we stopped cepharanthine and began 60 mg/day fexofenadine for remaining itching on the scalp. DPCP therapy was continued for a month but finally stopped because of headache after its application. Three months after the start of fexofenadine, the hair regrowth became apparent (Fig. 2B) and, 6 months later, cosmetically satisfactory regrowth was obtained (Fig. 2C). In the first case, during the continuation of the same regimen of DPCP immunotherapy, the switching of antihistamines from ebastin to fexofenadine seems to have enhanced the effect of DPCP on AA. Fexofenadine decreases the production of IFN-γ from T lymphocytes, as well as the expression of ICAM-1 on epithelial cells, supporting its efficacy for AA. Although IFN-γ is increased in the early induction phase of contact hypersensivity, repeated application of DPCP in the long term paradoxically decreases expression of IFN-γ in the AA lesions. Therefore, in the first case, fexofenadine and the DPCP contact immunotherapy may synergistically exert the inhibitory effect on IFN-γ . In the second case, the patient showed continuous hair recovery after DPCP therapy was stopped, causing us to speculate that she might be more susceptible to fexofenadine than to the contact immunotherapy in terms of IFN-γ inhibition. Recently, it has been reported that fexofenadine rapidly suppresses itch due to DPCP immunotherapy for AA, indicating that fexofenadine is an adequate concomitant drug. Additionally, our cases here indicate the possibility of fexofenadine as a combined or otherwise alternative drug to the contact immunotherapy for AA.
|
2022-12-19T01:49:28.685Z
|
36,573,679 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5455/JAVAR.2015.B45",
"MAG": "2108591341",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Perfect detection of estrus is crucial for good husbandry practice of cow. Estrus synchronization is the alternative strategy to bypass the critical problem of estrus detection. Synchronization program allows fixed timed artificial inseminations (FTAI) to evade the estrus detection. The most recently developed programs include protocols for re-synchronization following first or subsequent inseminations. These re-synchronization protocols may involve selected forms of hormonal intervention during the diestrus and pro-estrus periods following FTAI, or following pregnancy diagnosis by ultrasound from 28 days after FTAI. Almost all programs involve strategically timed treatment of prostaglandin F2α (PGF) and gonadotropin releasing hormone (GnRH). Treatment of an estradiol ester and progesterone supplementation per vaginum may be included in some programs. The basic program is the “Ovsynch” regimen. This mini-review discusses a number of key points related to external hormonal stimulation on ovarian follicular wave to improve pregnancy rate following timed AI.
|
2022-12-19T19:20:25.944Z
|
713,600 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/PCS.2016.7906371",
"MAG": "2610791845",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this paper, we propose a convex optimization method of prefilters for image coding. JPEG, which is the de facto image coding method, generally produces some errors, e.g., blocking artifacts, under the low bit rate case. The undersampled time-domain lapped transform (TDLT) can efficiently reduce the errors. To improve the performance of the undersampled TDLT, its prefilter is determined by minimizing the errors between the original image and the image upsampled from the downsampled one. This approach enhances the performance but there exists a room for further improvements since the image derived by the prefilter would not become a smoothed image whose charactaristic is important for image coding. To resolve the problem, we consider to minimize a cost function with ℓ1 regularization defined on the frequency domain of the downsampled image. It can be solved by using a convex optimization algorithm; the alternating direction method of multipliers. Some experimental results show the validity of our method.
|
2022-08-28T01:21:27.981Z
|
37,539,608 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/COMPEM.2015.7052572",
"MAG": "1977855257",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A pneumatically controlled patch antenna with resonant frequency that can be switched to either 3.05 GHz or 5 GHz is introduced. The resonant frequency of the device is determined by the dimension of the patch that is excited. To select a particular frequency, a pneumatically-operated copper-plated swinging arm is moved to cover one of two orthogonal slots on the ground plane. The uncovered slot allows energy to be coupled from the microstrip feedline to the corresponding dimension of the patch. Simulated results from HFSS are provided.
|
2022-03-26T04:36:04.618Z
|
248,222,229 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/app12084036",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2076-3417/12/8/4036/pdf?version=1650093677"
}
|
This study developed an automated temperature measurement and monitoring platform for dairy cattle. The platform used the YOLO V3-tiny (you only look once, YOLO) deep learning algorithm to identify and classify dairy cattle images. The system included a total of three layers of YOLO V3-tiny identification: (1) dairy cow body; (2) individual number (identity, ID); (3) thermal image of eye socket identification. We recorded each cow’s individual number and body temperature data after the three layers of identification, and carried out long-term body temperature tracking. The average prediction score of the recognition rate was 96%, and the accuracy was 90.0%. The thermal image of eye socket recognition rate was >99%. The area under the receiver operating characteristic curves (AUC) index of the prediction model was 0.813 (0.717–0.910). This showed that the model had excellent predictive ability. This system provides a rapid and convenient temperature measurement solution for ranchers. The improvement in dairy cattle image recognition can be optimized by collecting more image data. In the future, this platform is expected to replace the traditional solution of intrusive radio-frequency identification for individual recognition.
|
2022-07-27T11:02:04.519Z
|
72,689,365 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/J.1748-5827.1984.TB03417.X",
"MAG": "2082881893",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A case of impaction of the large intestine in the Marginated Tortoise (Testudo marginata) is described. It was associated with the ingestion of pebbles, probably in an attempt to obtain calcium.
|
2022-08-23T23:14:33.060Z
|
55,721,761 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1044/HHD16.2.55",
"MAG": "2139354815",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This article is a review of the strengths and weaknesses of modern digital hearing aids to be able to transduce music effectively. One major area that is problematic is the analog-to-digital (A/D) ...
|
2022-08-31T08:37:48.611Z
|
221,742,686 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3389/fendo.2020.572384",
"MAG": "3087111309",
"PubMedCentral": "7527830"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.frontiersin.org/articles/10.3389/fendo.2020.572384/pdf"
}
|
Polycystic ovary syndrome (PCOS) is reported to be associated with certain trace elements. However, previous data are inconsistent and potentially biased due to small sample sizes. The potential utility of trace element levels for screening of PCOS remains to be established. The aim of this meta-analysis was to investigate the potential relationships between PCOS and serum levels of zinc (Zn), copper (Cu), magnesium (Mg), iron (Fe) and ferritin. We carried out a literature search of PubMed, EMBASE, and Web of Science for relevant cross-sectional/case-control studies published prior to October 2019. Random-effect models were used to estimate the overall standard mean differences (SMDs) between PCOS and healthy control subjects. The screening value of potential microelement biomarkers for PCOS was assessed using the receiver operating characteristic (ROC) curve. Twenty-one studies featuring 2,173 women with PCOS and 1,897 healthy women were selected for analysis. Our results showed that Cu and ferritin levels were significantly higher in women with PCOS than healthy controls, with SMDs of 0.52 [95% confidence interval (CI): 0.38–0.67, I2 = 47.6%] and 1.05 (95% CI: 0.25–1.86, I2 = 97.0%), respectively. The serum ferritin concentration was distinguished as a potential biomarker for PCOS based on the high area under ROC curve value of 0.71 (95% CI: 0.57–0.86). Although we did not identify a statistical association between serum Zn concentration and PCOS overall, the concentration of Zn in PCOS women with insulin resistance (IR) was lower than that in healthy women (SMD = −0.89, 95% CI: −1.73 to −0.06). Furthermore, the concentrations of Mg (SMD = 0.31, 95% CI: −0.32–0.94, I2 = 95.4%) and Fe (SMD = −0.59, 95% CI: −1.29–0.12, I2 = 97.2%) were not statistically significant between the PCOS and control groups. We generated hypothetical pathways for associations among serum Cu, ferritin and PCOS. The serum concentrations of both Cu and ferritin were significantly higher in women with PCOS, and ferritin was identified as a potential early indicator for PCOS screening. Further studies are essential to determine the specific underlying mechanisms.
|
2022-09-22T15:30:27.235Z
|
171,384,027 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.18606/2318-1419/AMAZONIA.SCI.HEALTH.V3N3P30-33",
"MAG": "2563665592",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Introducao: Atualmente as doencas cronicas nao transmissiveis tem se apresentado com um aumento significante e gradativo. A lesao medular e uma das mais complexas lesoes existentes, sendo incapacitante. O fisioterapeuta na Unidade de Terapia Intensiva e considerado um componente importante na gestao desses pacientes. Objetivo: Identificar os principais cuidados fisioterapeuticos e sua atuacao com o paciente lesionado medular na UTI. Material e Metodo: Revisao bibliografica, usando com base referencia de 2005 a 2015. Contendo como criterios de inclusao artigos dentro do periodo estipulado, com os cuidados e atuacoes realizadas e os protocolos de atendimentos, sendo excluidos os que nao se enquadram nos criterios de inclusao. Usando como descritores Fisioterapia, Lesao medular e UTI. Resultados e Discussao: No protocolo avaliado os principais cuidados estariam uma completa avaliacao neurologica; inspecionar a presenca de traumatismos; avaliar deficits; manter vias aereas pervias; nao realizar aspiracao nasal caso haja traumatismo facial.A atuacao e bastante ampla, indo desde o seu inicio com suas avaliacoes, tratamento e na prevencao de complicacoes. Inicia-se com a mobilizacao precoce de extremidades, mobilizacao em bloco, estimulacao da musculatura respiratoria e estimular a tosse e avaliar a necessidade de ventilacao. Consideracoes finais: Atuando na reabilitacao com seus mais diversos recursos, a fisioterapia atua tanto nos cuidados quanto na intervencao no paciente lesado medular tornando seu trabalho de suma relevância nas UTI e no atendimento desse tipo de paciente, ja que a mesma visa nao so o tratamento, mas tambem a prevencao das complicacoes. Sugere-se a implementacao de protocolos. Descritores: Fisioterapia; UTI; Lesao Medular;
|
2022-12-02T11:08:35.174Z
|
98,734,818 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.22099/IJSTS.2010.2192",
"MAG": "2197389773",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Root and shoot osmotic and elastic properties of two species of Haloxylon aphyllum and H.persicum in response to water stress were studied. The main goal of the study was to determine if the tissuesof two species utilize osmotic adjustment and/or enhance their elastic property during prolonged water stresscondition. The results showed that although tissue elasticity of both species of haloxylon was enhanced due toapplication of repeated water stress cycles, this condition also increased the tissue osmotic potential.Therefore, this study concluded that haloxylon species utilize enhancement of elasticity rather than osmoticadjustment to maintain positive turgor and withstand drought
|
2022-09-08T11:12:40.795Z
|
43,578,696 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1536/ihj.16-617",
"MAG": "2582997876",
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://www.jstage.jst.go.jp/article/ihj/58/1/58_16-617/_pdf"
}
|
Incomplete thrombus resolution in patients with venous thromboembolism (VTE) may increase the risk of recurrent thromboembolic events and other complications, such as post-thrombotic syndrome. Various options exist for thrombus resolution, including systemic thrombolytic agents, catheter-directed thrombolysis, and traditional anticoagulants such as heparins or vitamin K antagonists (VKAs). Data are accumulating on the use of non-VKA oral anticoagulants, such as rivaroxaban, and these may provide greater thrombus resolution compared with VKAs. Data from the phase III rivaroxaban studies presented here show that a 21-day intensive dosing regimen of rivaroxaban 15 mg twice daily is effective during the acute treatment phase for VTE, with similar recurrence rates and thrombus resolution to standard anticoagulation. Pooled analyses of phase III studies have also indicated that rivaroxaban 20 mg once daily monotherapy for up to 12 months after this initial intensive treatment period may provide effective prevention of recurrent VTE and a reduction in the risk of major bleeding, irrespective of clot burden. Four case studies from the Darmstadt Academic Teaching Hospital, Germany, and Gunma University Hospital, Japan, are also provided. Further clinical studies and real-world data may improve our understanding of initial intensive dose regimens, and assess the full significance of thrombus burden in VTE.
|
2022-12-09T13:42:05.598Z
|
210,693,346 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/SIBIRCON48586.2019.8958202",
"MAG": "3000289295",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Recommender systems help users to orient in the vast space of goods, services, and events. A user interacts with the recommender engine in a sequence of exchanges of recommendations and user feedback. The idea that previous interaction influence the later ones and the importance of the sequence of interactions can be modeled using Markov decision processes and solved by reinforcement learning. Several recent articles applying reinforcement learning to recommender systems have proved the viability of this direction. But it is still difficult to compare different approaches. We propose an environment with a unified interface that will permit to compare different modelization of recommender process and different algorithms on the same underlying sequential data. We also performed the extensive parameter study for deep deterministic policy gradient methods on the well-known MovieLens dataset.
|
2022-12-16T08:05:25.743Z
|
52,304,925 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3389/fmicb.2018.02116",
"MAG": "2890801912",
"PubMedCentral": "6160750"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.frontiersin.org/articles/10.3389/fmicb.2018.02116/pdf"
}
|
The thermophilic, endospore-forming genus of Geobacillus has historically been associated with spoilage of canned food. However, in recent years it has become the subject of much attention due its biotechnological potential in areas such as enzyme and biofuel applications. One aspect of this genus that has not been fully explored or realized is its use as a source of novel forms of the ribosomally synthesized antimicrobial peptides known as bacteriocins. To date only two bacteriocins have been fully characterized within this genus, i.e., Geobacillin I and II, with only a small number of others partially characterized. Here we bioinformatically investigate the potential of this genus as a source of novel bacteriocins through the use of the in silico screening software BAGEL3, which scans publically available genomes for potential bacteriocin gene clusters. In this study we examined the association of bacteriocin gene presence with niche and phylogenetic position within the genus. We also identified a number of candidates from multiple bacteriocin classes which may be promising antimicrobial candidates when investigated in vitro in future studies.
|
2022-12-20T05:08:24.949Z
|
235,411,436 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/bmjopen-2020-046362",
"MAG": null,
"PubMedCentral": "8202113"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://bmjopen.bmj.com/content/bmjopen/11/6/e046362.full.pdf"
}
|
Introduction The primary aim of the National Institute of Health Research-funded global health research group, Warwick-India-Canada (WIC), is to reduce the burden of psychotic disorders in India. India has a large pool of undetected and untreated patients with psychosis and a treatment gap exceeding 75%. Evidence-based packages of care have been piloted, but delivery of treatments still remains a challenge. Even when patients access treatment, there is minimal to no continuity of care. The overarching ambition of WIC programme is to improve patient outcomes through (1) developing culturally tailored clinical interventions, (2) early identification and timely treatment of individuals with mental illness and (3) improving access to care by exploiting the potential of digital technologies. Methods and analysis This multicentre, multicomponent research programme, comprising five work packages and two cross-cutting themes, is being conducted at two sites in India: Schizophrenia Research Foundation, Chennai (South India) and All India Institute of Medical Sciences, New Delhi (North India). WIC will (1) develop and evaluate evidence-informed interventions for early and first-episode psychosis; (2) determine pathways of care for early psychosis; (3) investigate the efficacy and cost-effectiveness of community care models, including digital and mobile technologies; (4) develop strategies to reduce the burden of mental illnesses among youth; (5) assess the economic burden of psychosis on patients and their carers; and (6) determine the feasibility of an early intervention in psychosis programme in India. Ethics and dissemination This study was approved by the University of Warwick’s Biomedical and Scientific Research Ethics Committee (reference: REGO-2018-2208), Coventry, UK and research ethics committees of all participating organisations. Research findings will be disseminated through peer-reviewed scientific publications, presentations at learnt societies and visual media.
|
2022-12-24T17:39:45.986Z
|
9,329,783 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5194/ACP-14-2571-2014",
"MAG": "3001533073",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract. Drifts, trends and periodic variations were calculated from monthly zonally averaged ozone profiles. The ozone profiles were derived from level-1b data of the Michelson Interferometer for Passive Atmospheric Sounding (MIPAS) by means of the scientific level-2 processor run by the Karlsruhe Institute of Technology (KIT), Institute for Meteorology and Climate Research (IMK). All trend and drift analyses were performed using a multilinear parametric trend model which includes a linear term, several harmonics with period lengths from 3 to 24 months and the quasi-biennial oscillation (QBO). Drifts at 2-sigma significance level were mainly negative for ozone relative to Aura MLS and Odin OSIRIS and negative or near zero for most of the comparisons to lidar measurements. Lidar stations used here include those at Hohenpeissenberg (47.8° N, 11.0° E), Lauder (45.0° S, 169.7° E), Mauna Loa (19.5° N, 155.6° W), Observatoire Haute Provence (43.9° N, 5.7° E) and Table Mountain (34.4° N, 117.7° W). Drifts against the Atmospheric Chemistry Experiment Fourier Transform Spectrometer (ACE-FTS) were found to be mostly insignificant. The assessed MIPAS ozone trends cover the time period of July 2002 to April 2012 and range from −0.56 ppmv decade−1 to +0.48 ppmv decade−1 (−0.52 ppmv decade−1 to +0.47 ppmv decade−1 when displayed on pressure coordinates) depending on altitude/pressure and latitude. From the empirical drift analyses we conclude that the real ozone trends might be slightly more positive/less negative than those calculated from the MIPAS data, by conceding the possibility of MIPAS having a very small (approximately within −0.3 ppmv decade−1) negative drift for ozone. This leads to drift-corrected trends of −0.41 ppmv decade−1 to +0.55 ppmv decade−1 (−0.38 ppmv decade−1 to +0.53 ppmv decade−1 when displayed on pressure coordinates) for the time period covered by MIPAS Envisat measurements, with very few negative and large areas of positive trends at mid-latitudes for both hemispheres around and above 30 km (~10 hPa). Negative trends are found in the tropics around 25 and 35 km (~25 and 5 hPa), while an area of positive trends is located right above the tropical tropopause. These findings are in good agreement with the recent literature. Differences of the trends compared with the recent literature could be explained by a possible shift of the subtropical mixing barriers. Results for the altitude–latitude distribution of amplitudes of the quasi-biennial, annual and the semi-annual oscillation are overall in very good agreement with recent findings.
|
2022-12-30T00:18:00.860Z
|