corpusid
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255M
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24
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110,149,217 |
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"DOI": "10.3846/MLA.2011.027",
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|
Straipsnyje apžvelgiama nelaimingų atsitikimų darbe statistika. Pateikiami darbų saugos sistemos tobulinimo būdai, aprasomas kompleksinio sistemos vertinimo modelio formavimas ir realizavimas. Pateikiamas rizikos vertinimas ir nurodomos konkrecios priemonės darbų saugos sistemos statybos įmonėse efektyvumui didinti. Straipsnis lietuvių kalba
|
2022-12-10T23:28:31.481Z
|
23,510,409 |
{
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"DOI": "10.1113/jphysiol.2008.159616",
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"license": null,
"status": "GREEN",
"url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670033"
}
|
T1R taste receptors are present throughout the gastrointestinal tract. Glucose absorption comprises active absorption via SGLT1 and facilitated absorption via GLUT2 in the apical membrane. Trafficking of apical GLUT2 is rapidly up‐regulated by glucose and artificial sweeteners, which act through T1R2 + T1R3/α‐gustducin to activate PLC β2 and PKC βII. We therefore investigated whether non‐sugar nutrients are regulated by taste receptors using perfused rat jejunum in vivo. Under different conditions, we observed a Ca2+‐dependent reciprocal relationship between the H+/oligopeptide transporter PepT1 and apical GLUT2, reflecting the fact that trafficking of PepT1 and GLUT2 to the apical membrane is inhibited and activated by PKC βII, respectively. Addition of l‐glutamate or sucralose to a perfusate containing low glucose (20 mm) each activated PKC βII and decreased apical PepT1 levels and absorption of the hydrolysis‐resistant dipeptide l‐Phe(ΨS)‐l‐Ala (1 mm), while increasing apical GLUT2 and glucose absorption within minutes. Switching perfusion from mannitol to glucose (75 mm) exerted similar effects. l‐Glutamate induced rapid GPCR internalization of T1R1, T1R3 and transducin, whereas sucralose internalized T1R2, T1R3 and α‐gustducin. We conclude that l‐glutamate acts via amino acid and glucose via sweet taste receptors to coordinate regulation of PepT1 and apical GLUT2 reciprocally through a common enterocytic pool of PKC βII. These data suggest the existence of a wider Ca2+ and taste receptor‐coordinated transport network incorporating other nutrients and/or other stimuli capable of activating PKC βII and additional transporters, such as the aspartate/glutamate transporter, EAAC1, whose level was doubled by l‐glutamate. The network may control energy supply.
|
2022-12-18T15:08:58.682Z
|
10,800,177 |
{
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"ArXiv": null,
"DOI": "10.1111/bjh.13852",
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"license": null,
"status": "BRONZE",
"url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.13852"
}
|
Acute lymphoblastic leukaemia is the most common childhood cancer and for those children who relapse, prognosis is poor and new therapeutic strategies are needed. Recurrent pathways implicated in relapse include RAS, JAK STAT, cell cycle, epigenetic regulation, B cell development, glucocorticoid response, nucleotide metabolism and DNA repair. Targeting these pathways is a rational therapeutic strategy and may deliver novel, targeted therapies into the clinic. Relapse often stems from a minor clone present at diagnosis and thus analysis of persisting leukaemia during upfront therapy may allow targeted drug intervention to prevent relapse.
|
2022-12-23T02:21:14.999Z
|
31,949,265 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.14219/JADA.ARCHIVE.1979.0258",
"MAG": "2040260827",
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"url": null
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|
Removal and treatment of an enamel pearl, a contributing factor to periodontal disease because of its anatomy and location, are described.
|
2022-12-27T21:13:47.742Z
|
238,779,818 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/pr9081318",
"MAG": "3190922436",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2227-9717/9/8/1318/pdf?version=1627552724"
}
|
The world is facing serious threats from the depletion of non-renewable energy resources, freshwater shortages and food scarcity. As the world population grows, the demand for fresh water, energy, and food will increase, and the need for treating and recycling wastewater will rise. In the past decade, wastewater has been recognized as a resource as it primarily consists of water, energy-latent organics and nutrients. Microbial fuel cells (MFC) have attracted considerable attention due to their versatility in their applications in wastewater treatment, power generation, toxic pollutant removal, environmental monitoring sensors, and more. This article provides a review of MFC technologies applied to the removal and/or recovery of nutrients (such as P and N), organics (COD), and bioenergy (as electricity) from various wastewaters. This review aims to provide the current perspective on MFCs, focusing on the recent advancements in the areas of nutrient removal and/or recovery with simultaneous power generation.
|
2022-12-28T18:20:08.137Z
|
121,898,985 |
{
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"ArXiv": null,
"DOI": "10.1109/ULTSYM.1994.401734",
"MAG": "2163749784",
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"url": null
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|
The resonant nature of ground motion above a semi-circular basin is demonstrated theoretically from the rigorous formulation and solution of the problem. The resonances are shown to be connected with the excitation of the normal modes of the bedrock-basin system. The analytical form of these modes is derived and exact as well as approximate procedures are given for computing the characteristic frequencies
|
2022-02-09T19:45:30.534Z
|
9,158,850 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1460-9592.2008.02912.x",
"MAG": "1984663620",
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"url": null
}
|
SIR—We read with interest the recent correspondence of Johr et al. (1) regarding the use of remifentanil for inducing apnea during diagnostic imaging in sedated pediatric patients. To induce a short period of apnea requested for diagnostic imaging, they provide a regimen of bolus dose remifentanil followed by naloxone reversal. Except for several limitations of this technique that the authors have pointed out in this correspondence, however, following questions should also be noted. (i) For sedation with ketamine and propofol, intramuscular ketamine or achieving intravenous (i.v.) access may be distressing to the child, though this is less likely with the use of topical local anesthetic creams. (ii) A sedation regimen of combined three i.v. anesthetics (ketamine, propofol and remifentanil) seems somewhat complex. Also the unanticipated synergistic action among drugs may put the child at risks of increased complications and prolonged recovery (2). (iii) When combined with propofol in children, rapid injection of remifentanil 2 lgÆkg can cause significant cardiovascular depression, such as hypotension and bradycardia, especially when an anticholinergic agent is concurrently not used (3). These undesired cardiovascular effects are impossible to cause in severe outcomes in healthy children, but they may cause severe cardiovascular instability in children with bad general condition or impaired cardiac function. (iv) Bolus injection of naloxone 10–50 lgÆkg for reversal of apnea by remifentanil may cause transient hyperdynamic circulatory status because of extreme sympathetic nervous system activity or an effect of the drug on peripheral or central opioid receptors (4). Many case reports indicate that naloxone in its role of narcotic antagonist may induce hypertension, pulmonary edema, atrial, and ventricular arrhythmias, or cardiac arrest in certain patients, particularly those with preexisting cardiac abnormalities (5). Patient safety has been considered to be of paramount importance by anesthetists. For a child requiring a brief period of apnea during diagnostic imaging, therefore, we prefer the following scheme to perform anesthesia and ventilation management. Anesthesia is induced using incremental sevoflurane, up to 8%, in 40% oxygen and 60% nitrous oxide via a semi-closed anesthetic circuit. After the child lost consciousness, nitrous oxide, which is initially used to hasten induction, is discontinued. Then an i.v. access is achieved and 0.02 mgÆkg atropine is given i.v. By adjusting inspired concentration of sevoflurane, an end-tidal concentration of 3% is maintained. After positioning and performing the scout scan, the child’s head is placed in the neutral position and a suitable roll of gauze is placed under the child’s neck to keep the neck extension. An oral airway is inserted to maintain the airway patency and a facemask is held firmly on the child’s face using a mask strap. If the upper airway obstruction occurs during sevoflurane induction or the anesthetist feels difficulty in maintaining a patent airway by the neck extension and use of an oral airway, a LMA is used to replace the facemask. Then an oxygen flow of 3 lÆmin is used and the release pressure of the pop-off valve is set at 15 cmH2O. Subsequently, 1 lgÆkg remifentanil is injected i.v. over 5 s. After a period of 15–20 s, spontaneous breathing disappears and the imaging data is taken under apneic oxygen insufflation. If spontaneous breathing does not stop after initial dose of remifentanil, an increment dose of 0.5 lgÆkg is supplemented. After acquisition of the imaging data, sevoflurane is turned off and the child’ lungs are ventilated via a facemask or a LMA with 100% oxygen. The adequate spontaneous breathing often recovers within 5 min and the child is awake within 10–15 min. If the spontaneous breathing does not recover in the desired period of time, naloxone is given i.v., in fractional doses from 1 to 5 lgÆkg. According to our experience in 158 children, this technique has several main advantages. (i) Initial use of sevoflurane inhalational anesthesia with maintenance of spontaneous ventilation helps to determine whether child’s airway can safely managed by facemask. (ii) Under sevoflurane anesthesia, rapid bolus injection of remifentanil 1 lgÆkg can provide a highly predictable period of apnea required for acquisition of diagnostic imaging data in 98.7% (156 ⁄ 158), without undesired cardiovascular depression. (iii) By a tightly closed facemask or a correctly placed LMA, oxygen may be continuously insufflated into the child’s lungs. Also this low continuous airway positive pressure of 15 cmH2O may improve the image quality for evaluating the lung structures and does not cause undesired gastric insufflation. (iv) It can provide a rapid uneventful recovery in most of children (96.8%, 153 ⁄ 158) and only requires a short stay in the postanesthetic recovery room. (v) When delayed recovery of spontaneous breathing occurs in minority cases, reversal of small dose naloxone is effective, without significant untoward cardiovascular changes. Pediatric Anesthesia 2009 19: 267–287
|
2022-02-13T07:37:34.954Z
|
138,863,222 |
{
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"ArXiv": null,
"DOI": "10.1177/0040517514530028",
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"status": null,
"url": null
}
|
Though ZnO nanoparticles (NPs) are an excellent UV absorber, their photocatalytic activity greatly limits the application areas of these particles. Under sunlight exposure, ZnO NPs used as a UV absorber can accelerate the wool yellowing process by generating free radicals. To reduce this photocatalysis effect, a physical barrier has been fabricated by coating the ZnO NPs with a silica layer (ZnO@SiO2), hence providing good UV-shielding with low photocatalytic activity. The structure and optical properties of ZnO and ZnO@SiO2 NPs were characterized by transmission electron microscope (TEM) and UV–Vis spectrum. The photocatalytic activity of ZnO and ZnO@SiO2 NPs was evaluated by photo-degradation of Rhodamine B. The ZnO and ZnO@SiO2 NPs were applied to knitted wool fabrics using the dip coating method. The treated wool fabrics were characterized by a scanning electron microscope (SEM) and the photoyellowing level of treated fabrics after exposure under simulated sunlight was evaluated by a Datacolor Spectraflash spectrophotometer. The ZnO@SiO2 NPs demonstrated excellent protection of wool against photoyellowing.
|
2022-08-20T04:28:11.493Z
|
94,826,686 |
{
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"ArXiv": null,
"DOI": "10.1021/ED035P493",
"MAG": "2029906276",
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}
|
Examines a variety of procedures involved in the production of chemical cellulose from wood, including the viscose, cuprammonium, cellulose acetate, and cellulose nitrate processes.
|
2022-09-02T14:30:46.939Z
|
244,634,536 |
{
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"ArXiv": null,
"DOI": "10.3934/math.2022042",
"MAG": "3207822063",
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},
"license": "CCBY",
"status": "GOLD",
"url": "https://doi.org/10.3934/math.2022042"
}
|
In this paper, for the first time, we apply symmetric $ q $ -calculus operator theory to define symmetric Salagean $ q $-differential operator. We introduce a new class $ \widetilde{\mathcal{H}}_{q}^{m}\left(\alpha \right) $ of harmonic univalent functions $ f $ associated with newly defined symmetric Salagean $ q $-differential operator for complex harmonic functions. A sufficient coefficient condition for the functions $ f $ to be sense preserving and univalent and in the same class is obtained. It is proved that this coefficient condition is necessary for the functions in its subclass $ \overline{\widetilde{\mathcal{H}}_{q}^{m}\left(\alpha \right) } $ and obtain sharp coefficient bounds, distortion theorems and covering results. Furthermore, we also highlight some known consequence of our main results.
|
2022-10-21T16:14:26.157Z
|
121,724,020 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1155/S1048953396000214",
"MAG": "2048774246",
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|
A significant increase in computing power has enabled many fields to forge ahead and tackle problems much too complex to be solved analytically. The older researchers among us have seen computing move from slide rules and hand cranked calculators to punch cards and batch proces-sing, then to teletype terminals, and on to the now ubiquitous desktop machines and their net-works, packing more power than the mainframes of yesteryear. Although the growth in computing power has been a catalyst to the growth of many areas of applied mathematics, the ability to harness that power will always depend critically on the ana-lyst’s ability to think algorithmically. The cultivation of that ability is not easy, particularly in applied probability, where there are too few good books that incorporate algorithmic methods as an integral part of their exposition. "Algorithmic Probability," by Marcel F. Neuts, a pioneer in this area, makes an invaluable contribution, and can help make the development of critical algorithmic thinking skills an integral part of one’s training in probability. Preparing a set of exercises is often the most difficult part of writing a textbook, and it goes without saying that writing an entire book of problems in a growing area like applied probability is a challenge that few can meet. This book bears testimony to the author’s many decades of experience in teaching algorithmic methods, and more importantly, to his practice of that discipline through hands-on computing. is most remarkable is the way in which the book lives up its stated ideal of "struc-turing a body of knowledge to guide the learner to an integrated understanding and indepen-dent, critical thinking." important steps, including:
|
2022-07-09T09:01:58.834Z
|
138,564,344 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1111/J.1151-2916.1972.TB13451.X",
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"status": null,
"url": null
}
|
The contribution of plastic flow to overall densification of a powder compact during hot-pressing was analyzed by incorporating the creep characteristics of materials at high temperatures into an equation applicable to hot-pressing conditions. When the particles are assumed to be spherical and when the effective stress acting at the points of contact under axial loading conditions is taken into consideration, the final form of the equation is:
where α1 and β are geometric constants which can be calculated from the packing geometry, A and n are material constants, D is the relative density of the compact, and R is the radius of the spheres at any stage of deformation in arbitrary units. Computerized plots of D vs t were obtained for several materials. Experimental verification of these plots using hot-pressing data for Pb-2% Sb, Ni, and Al2O3 spheres and coarse irregular Al2O3 particles showed that the experimental data fitted the theoretical prediction for orthorhombic packing well. A large deviation with respect to the initial packing density was encountered with very fine irregular Al2O3 powder, although its densification behavior with time was similar to that of the coarse particles.
|
2022-09-13T13:17:11.864Z
|
43,833,587 |
{
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"ArXiv": null,
"DOI": "10.5271/sjweh.3420",
"MAG": "2012842040",
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},
"license": "CCBY",
"status": "HYBRID",
"url": "https://www.sjweh.fi/download.php?abstract_id=3420&file_nro=1"
}
|
OBJECTIVE
Post-traumatic stress disorder (PTSD) develops according to consensus criteria within the first 1-6 months after a horrifying traumatic event, but it is alleged that PTSD may develop later. The objective was to review the evidence addressing occurrence of PTSD with onset >6 months after a traumatic event (delayed-onset PTSD).
METHODS
Through a systematic search in PubMed, EMBASE, and PsycINFO, we identified 39 studies with prospective ascertainment of PTSD. A meta-analysis was performed in order to obtain a weighted estimate of the average proportion of delayed-onset PTSD cases, and meta-regression was used to examine effects of several characteristics
RESULTS
Delayed-onset PTSD was reported in all studies except one, and the average prevalence across all follow-up time was 5.6% [95% confidence interval (95% CI) 4.3-7.3%]. The proportion with delayed-onset PTSD relative to all cases of PTSD was on average 24.5% (95% CI 19.5-30.3%) with large variation across studies. In six studies with sub-threshold symptom data, delayed-onset PTSD seemed most likely an aggravation of early symptoms. The proportion with delayed-onset PTSD was almost twice as high among veterans and other professional groups compared to non-professional victims.
CONCLUSION
Descriptive follow-up data suggest that PTSD may manifest itself >6 months after a traumatic event, delayed-onset PTSD most often, if not always, is preceded by sub-threshold PTSD symptoms, and a higher proportion of PTSD cases are delayed among professional groups. Contextual factors and biased recall may inflate reporting of PTSD and a cautious interpretation of prevalence rates seems prudent.
|
2022-12-16T13:46:46.196Z
|
84,841,906 |
{
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"DOI": "10.1080/09205063.2019.1592797",
"MAG": "2924549521",
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"license": null,
"status": null,
"url": null
}
|
Abstract Degradable hemostatic agents are the essential materials for controlling the hemorrhage. Hemostatic oxidized cellulose carboxylate sodium fiber (OCCSF) has been synthesized via a simple neutralization reaction between water-insoluble oxidized cellulose fiber (OCF) and NaOH. Importantly, the degradation mechanisms of OCCSF have been investigated in vitro assay. Chemical structure of the material is tested by using FT-IR and NMR, and no obvious change was detected before and after degradation. Degree of polymerization (DP) of OCCSF declines with prolonging the degradation period, accompanying with the decrease in carboxyl content (CC), so that it could be concluded that OCCSF may undergo decarboxylation degradation process. Besides, combined the change of fiber color with UV, another elimination degradation mechanism of OCCSF could be deduced, and this has been demonstrated using 1,2-cyclohexanedione as the model compound.
|
2022-12-17T23:32:02.722Z
|
245,305,036 |
{
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"ArXiv": null,
"DOI": "10.1093/geroni/igab046.1530",
"MAG": null,
"PubMedCentral": "8680005"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://doi.org/10.1093/geroni/igab046.1530"
}
|
Abstract “Design Thinking,” an innovative, human-centric approach to problem-solving, seeks to ensure that design efforts “solve the right problem.” This presentation describes the Design Thinking process and illustrates its use in the context of three design studio sessions with of family caregivers of patients at the Integrated Memory Care Clinic (IMCC), a comprehensive medical home for persons living with dementia. The Design Thinking process entails five steps – Empathize, Define, Ideate, Prototype, Test – that engage consumers/end-users to identify, as precisely as possible, the issues or concerns that are most important to them and to further identify the possible solutions that seem to most fully address these concerns. The process can be described as one of divergent and convergent thinking. In the first session, the Empathize phase, IMCC caregivers were asked to think as broadly as possible about needs not being met by IMCC. These topics were reviewed more convergently in the second session, the Define phase; here the participants agreed on a shorter, prioritized list of needs to be addressed. In the third session (that combined the Ideate and pre-Prototype stages), participants identified 14 topics (interventions) they felt should be included in this program. Finally, in the Test phase, they assessed the topics and agreed that the most important need IMCC could address would be to provide a comprehensive orientation program for new caregivers. IMCC clinicians concurred with the salience of the problem to be solved and saw addressing it as contributing substantially to the improvement of IMCC clinical care.
|
2022-12-10T09:19:01.695Z
|
824,515 |
{
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"ArXiv": "cond-mat/0306711",
"DOI": "10.1103/PhysRevE.72.025701",
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|
We present a mathematical analysis of the Wang-Landau algorithm, prove its convergence, and identify sources of errors and strategies for optimization. In particular, we found the histogram increases uniformly with small fluctuations after a stage of initial accumulation, and the statistical error is found to scale as square root of (ln f) with the modification factor f . This has implications for strategies for obtaining fast convergence.
|
2022-12-29T19:49:43.939Z
|
114,017,588 |
{
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"ArXiv": null,
"DOI": "10.21535/ProICIUS.2015.v11.713",
"MAG": "2595012720",
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},
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"status": null,
"url": null
}
|
Controller design has been identified as one of the major activity in small scale unmanned helicopter development. Several approaches have been reported with varying degree of achievement and performance both in simulation and real-time implementation. This paper presents a survey of relevant research on control of the unmanned helicopter. The objective is to provide summary of the state of the art approaches in control design for the system with respect to modeling and implementation issues regarding flight control system. The unmanned helicopter flight control components and objectives are introduced first. Several model based and non-model based control design methods are presented with a view to highlight the strength and weakness of each of them. Conclusion is made with summary of the current trend, challenges and future direction in the control of unmanned helicopter.
|
2022-01-27T11:55:41.230Z
|
134,323,243 |
{
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"ArXiv": null,
"DOI": "10.30732/IJBBB.20180302003",
"MAG": "2889663953",
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"status": null,
"url": null
}
|
With the increase of population and change in lifestyle, the quantity and quality of solid waste has drastically changed in Indian society. Aspects involved in solid waste management are mostly, collection, transportation, disposal and processing. The disposal of solid waste is concerned with disposal process followed and availability of disposal land. Proper care should be taken in choosing the disposal area and disposal mechanism. Monitoring of the sites is priority criteria for successful management of solid waste as leachate generation occurs which is associated with ground water as well as surface water contamination near dumping sites. Surface water system situated near the disposal or landfill sites shows more toxicity as the dose of toxicants passage from the nearby landfill [1]. This note is simplified on the basis of guidelines on landfill gas management by SEPA, 2004 [2]. Through this short note, authors make a glimpse of landfill gas characteristics and management practices.
|
2022-02-09T12:12:43.797Z
|
92,024,707 |
{
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"DOI": "10.31983/keslingmas.v37i4.3800",
"MAG": "2914100284",
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},
"license": "CCBY",
"status": "GOLD",
"url": "https://ejournal.poltekkes-smg.ac.id/ojs/index.php/keslingmas/article/download/3800/976"
}
|
AbstrakDemam berdarah dengue ditularkan oleh nyamuk Aedes aegypti yang menjadi vektor utama. Cara yangpaling banyak dilakukan untuk mengurangi populasi vektor nyamuk DBD stadium larva adalah denganbahan kimia yang membahayakan kesehatan manusia. Banyak cara yang aman untuk membunuh vektorpenyakit DBD dan mencegah berkembangnya, salah satunya dengan menggunakan insektisida hayati By-Vii. By Vii adalah agen hayati yang didalamnya terdapat kandungan aktif jamur Beauveria bassianaTujuan dari penelitian ini adalah untuk menganalisis konsentrasi By-Vii yang paling efektif terhadapkematian larva Aedes aegypti. Metode yang digunakan dalam penelitian ini adalah True Experimentdengan rancangan post test only control group design untuk menghitung kematian larva Aedes aegyptipada konsentrasi 10%, 20%, dan 30% larutan By-Vii. Hasil penelitian larutan By-Vii terhadap kematianlarva Aedes aegypti mempunyai signifikasi 0,91 (0,05) yang berarti tidak ada pengaruh konsentrasi By-Vii terhadap kematian larva Aedes aegypti konsentrasi 10% dengan kematian 9,3%, konsentrasi 20%dengan kematian 8%, dan konsentrasi 30% dengan kematian 13,3%.Simpulan dari penelitian ini adalah larutan By-Vii mampu membunuh larva Aedes aegypti sebesar 13,3%.Hal tersebut menunjukkan bahwa larutan By-Vii tidak efektif digunakan sebagai larvasida. Diharapkanpenelitian selanjutnya menggunakan waktu pajanan By-Vii terhadap larva lebih dari 48 jam danmenambah konsentrasinya untuk mengetahui keefektifan produk By-Vii.
|
2022-02-10T18:13:18.011Z
|
234,148,072 |
{
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"DOI": "10.37506/MLU.V21I1.2408",
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"status": null,
"url": null
}
|
Background: Open fractures of leg are quite common in Road traffic accidents. The ideal protocol for openfractures of leg is initial thorough debridement, soft tissue coverage and intramedullary nailing or externalfixator application. External fixator may be later converted to internal fixation with reamed or unreamedintramedullary nail or left as a definitive treatment.Methodology: This prospective study was conducted at Rohilkhand Medical College And Hospital fromJanuary 2019 to January 2020 on patients presenting with open tibial fracture. Tubular External Fixator wasused. Total 30 patients were enrolled in this study.Results: In our study 30 patients were included in which 20 were male and 10 were females with meanage 32.2 years including children and elderly age group there was no age bar. Mean operative time was 60minutes. Average time for union was 24 weeks.Conclusion: External fixation as a primary definitive treatment for open tibial fracture is a cost effectiveprocedure in developing country with minimal morbidity and mortality.
|
2022-08-18T05:34:29.363Z
|
161,706,540 |
{
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"ArXiv": null,
"DOI": "10.4000/regulation.9120",
"MAG": "1572278465",
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},
"license": "CCBYNCND",
"status": "GOLD",
"url": "https://doi.org/10.4000/regulation.9120"
}
|
Pays en developpement, nouveaux pays industrialises, puis pays emergents, le Tiers Monde d’Alfred Sauvy (1952) n’en finit plus de se disloquer. Des lors qu’un pays autrefois qualifie de PED (Pays en developpement) presente des taux de croissance par habitant rapide et que, plus surement, s’y ouvrent des marches porteurs, la question de la nature des changements productifs, sociaux et institutionnels dont ils resultent se trouve posee. S’opere alors une sortie hautement symbolique des PED au p...
|
2022-09-14T12:57:35.237Z
|
9,923,641 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1155/2014/750459",
"MAG": "2056951397",
"PubMedCentral": "3988735"
},
"license": "CCBY",
"status": "GOLD",
"url": "http://downloads.hindawi.com/journals/joph/2014/750459.pdf"
}
|
Glaucoma is an optic neuropathy that affects 60 million people worldwide. The main risk factor for glaucoma is increased intraocular pressure (IOP), this is currently the only target for treatment of glaucoma. However, some patients show disease progression despite well-controlled IOP. Another possible therapeutic target is the extracellular matrix (ECM) changes in glaucoma. There is an accumulation of ECM in the lamina cribrosa (LC) and trabecular meshwork (TM) and upregulation of profibrotic factors such as transforming growth factor β (TGFβ), collagen1α1 (COL1A1), and α-smooth muscle actin (αSMA). One method of regulating fibrosis is through epigenetics; the study of heritable changes in gene function caused by mechanisms other than changes in the underlying DNA sequence. Epigenetic mechanisms have been shown to drive renal and pulmonary fibrosis by upregulating profibrotic factors. Hypoxia alters epigenetic mechanisms through regulating the cell's response and there is a hypoxic environment in the LC and TM in glaucoma. This review looks at the role that hypoxia plays in inducing aberrant epigenetic mechanisms and the role these mechanisms play in inducing fibrosis. Evidence suggests that a hypoxic environment in glaucoma may induce aberrant epigenetic mechanisms that contribute to disease fibrosis. These may prove to be relevant therapeutic targets in glaucoma.
|
2022-12-19T06:42:33.135Z
|
238,222,006 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/SEST50973.2021.9543338",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The network operators in Finland are facing new challenges in reactive power control. This paper focuses on the reactive power flow at the TSO/DSO interface. The motivation is to add the control ability of reactive power by a market-based approach where so far untapped flexible inverter-based resources connected to the distribution system are used as controllable assets. This development benefits the Distribution System Operator and the work opens new business opportunities especially to asset owners and aggregators. A local reactive power market is demonstrated as a novel solution. As a part of the market concept, a forecast of reactive power at the $T$SO/DSO interface was developed and utilized by the Distribution System Operator. The reactive power demonstration was performed with two assets, a battery energy storage system and a photovoltaic power plant. The assets were controlled by an aggregator. The demonstration period was successfully performed. The work presented in this paper has been done as a part of the Finnish demonstration of the EU-SysFlex project. The presented approach also builds upon the current EU targets for the development of various market-based flexibility services. However, the development of these applications also challenges the aggregators and flexibility providers, since the control of manifold types of assets requires various technical solutions that may be case dependent. This may complicate the fluent scalability of the solutions.
|
2022-12-27T17:45:55.631Z
|
136,914,869 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5978/ISLSM.10.117",
"MAG": "2000106143",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Although recent studies show that low reactive-level laser irradiation has some effects on several immune responses, few studies have examined the effect of diode laser irradiation on picryl contact sensitivity, a kind of cellular immunity. This study consisted of three experiments to evaluate the effect of diode laser irradiation (DLI) on picryl contact sensitivity in mice. First, (Exp.1), the laser irradiation site (right ear) was the same as the challenge site (right ear). Second, (Exp.2), the irradiation site (proximal portion of tail) was remote from the challenge site (right ear) Third, (Exp.3) we evaluated the penetration of diode laser energy through the irradiation site (right ear) compared with a range of incident powers. The effect of DLI for picryl contact sensitivity was evaluated with measurements of any increase of the ear thickness. The irradiation times in Exp.1 and Exp.2 were 15, 30 and 60 min. The results showed that DLI suppressed the cutaneous inflammation of picryl contact sensitivity in an exposure time dependent manner and this suppressive effect was restricted to within the irradiation site. 60 min irradiation in the challenge site was remarkably effective, however irradiation of the remote site did not affect the ear thickness increments in the challenge site. The penetration of laser energy through the ear was almost 50% of its output power in the whole range of powers tested.
|
2022-12-30T01:13:20.803Z
|
196,507,402 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/annrheumdis-2019-eular.5459",
"MAG": "2950785946",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://ard.bmj.com/content/annrheumdis/78/Suppl_2/393.3.full.pdf"
}
|
Background: Antiphospholipid syndrome (APS) is an autoimmune thrombophillia characterized by recurrent thromboembolism and/or pregnancy morbidity in the presence of Antiphospholipid antibodies mainly anti-β2glycoprotein I (anti-β2GPI), which lead to monocyte and endothelial cell activation and subsequent tissue factor and proinflammatory cytokine expression such us IL-6 and IL-8 (1). Epigenetics describes changes in gene expression without alterations in the genomic sequence. Methylation of DNA at CpG islands by adding a methyl group to the nucleotide cytosine, is one of main epigenetic mechanisms. Objectives: To explore the possible differential methylation of IL8 and Tissue Factor (F3)gene promoters, which are critical for the pathophysiology of APS. Methods: Whole blood and serum were isolated from 27 APS patients and 25 healthy donors (HDs). Human umbilical vein endothelial cells (HUVECs) and peripheral blood monocytes were isolated from 3 HDs. Anti-β2GPI IgG was isolated and pooled from 8 APS patients.HUVECs and monocytes were stimulated with a mixture of IgG, β2GPI and CXCL4.Then mRNA was isolated and qPCR was performed for the assessment of IL8 and tissue factor (F3)gene expression.Whole blood DNA from APS patients and HDs,and DNA from the in vitro experiments was isolated and bisulphite treated. The methylation of 1CpG in the promoter of F3 gene and 1CpG in the promoter of IL8 gene was assessed with Methylation Specific PCR Results: DNA from APS patients had significantly lower methylation levels in the IL8 promoter compared to HDs (mean: APS 0,6715vs HD1,153, p < 0,0001). Patients with history of arterial thromboembolism had the lowest IL8 methylation levels compared to ones with history of venous thrombosis or pregnancy morbidity, p=0.0003.An inverse correlation was noted between the IL8 methylation levels and the time passed since the last clinical event. APS patients who suffered 3 or more clinical incidents had significantly lower methylation levels. APS DNA was significantly methylated in the F3 promoter compared to HD (APS 1,902vs HD1,335, p<0,0001). Negative association of F3 methylation was noted with anti-β2GPI, auto-antibody titers and APTT elongation. HD HUVECs and monocytes stimulated with anti-β2GPI IgG/β2GPI/CXCL4 obtained an activated and procoagulant phenotype. In HUVECs the triple mixture induced an 8fold increase for the SELE gene, 3fold for the IL8, 1.5fold for F3. At the same time 2-fold decreased F3 promoter methylation levels correlated inversely to F3 gene expression (r -0.7679, p=0.0008). No change was noted in the IL8 promoter methylation levels.Treated monocytes had a 40fold increase in the IL8 and 20 fold increase in the F3 gene levels, while methylation of IL-8 and F3 promoter regions was decreased by 2-fold. HUVECs stimulation resulted in the differential expression of genes involved in DNA epigenetic alterations. Significant difference was observed for MeCP2 (2fold), DNMT3B (2 fold) and HDAC9 genes (3fold), which correlate with theexpression of activation markers of SELE, F3 and IL8. Conclusion: APS patients expressed decreased relative IL8 methylation levels which associate with arterial clinical events and significantly with more recent events. The mixture of anti-β2GPI IgG-β2GPI-CXCL4 activate HD HUVECs and monocytes to a procoagulant phenotype and decrease methylation in the F3 and IL8 promoters. References: [1] Allen, K.L., et al., A novel pathway for human endothelial cell activation by antiphospholipid/anti-beta2 glycoprotein I antibodies. Blood, 2012. 119(3): p.884-93. Disclosure of Interests: None declared
|
2022-02-08T07:02:54.129Z
|
88,437,961 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.5274/JSBR.18.2.116",
"MAG": "2312191530",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A number of attempts to reduce suga r loss in sto red sugarbeets by protection with pile cove ring materia l have been made by C.S. sugar companies but. little has been published on the resul ts of those a ttem p ts ( l , 4)2 Loss of sugar and recove rable suga r in the rim or outer two feet of the pile is two to four times as great as th e loss in the interior of the pil e where beets a re not subjected to dehydration and alternate freezing and thawin g (1, 5). Akeson, et a l (l) reported that coverin g a pile with a layer of straw, a woven plas tic material or a com bination of the tw o substantially reduced the sugar loss in the outer portion of the pil e. Measurement of the re lative sugar losses in the rim with differe nt systems of pile protection will show whether a type of co vering has poten tia l for reducing losses. However, the pile covering may cause undesirable conditions in the interio r of the pile suc h as hea ting or interio r freez ing which will increase losses in the interior an d offset a saving of sugar on the rim. Therefore, final evalua tio n of a pile protec tion material must be made on the entire pil e. Since weather condi tions vary from year to year, three or more years' data a re required to prove that a material is effective in red ucin g storage loss. In th is paper, data are presen ted for four years of comparisons between non-covered a nd straw covered piles and tw o years of com parisons between non-covered pi les and piles which are covered with woven po lypropyle ne plastic sheetin g.
|
2022-02-10T20:31:16.726Z
|
241,338,771 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.32474/rrhoaj.2020.05.000207",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://lupinepublishers.com/research-and-reviews-journal/pdf/RRHOAJ.MS.ID.000207.pdf"
}
|
Familial Mediterranean Fever (FMF) is the most common and best known of hereditary recurrent fever or periodic fever syndromes. It was described in 1945 and genetically characterized in 1992; caused by a point mutation in the “MEFV” gene located on the short arm of chromosome 16. It is particularly frequent among Sephardic Jews, Armenians, Turks and Middle Eastern Arabs where the prevalence can reach 1/2000 to 1/1000. Recent publications objectified its frequent association with other diseases and/or syndromes, particularly those of autoimmune, genetic, and auto-inflammatory origin. The objective of this review is to familiarize healthcare professionals with the main associations to look for in patients followed for FMF. The early detection of these associations makes it possible to improve the management and the prognosis of patients with FMF.
|
2022-07-31T10:06:30.930Z
|
15,491,394 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4304/jcp.9.5.1090-1095",
"MAG": "2043281449",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Abstract—Text in video is a very compact and accurate clue for video indexing and summarization. The paper presents a new method for text location in news video with ant colony algorithm. Three features of characters are extracted as a basis for the formation of heuristic function. In order to balance the weight of the three features, three functions are introduced to transform them. The ants will be randomly put on sub-blocks of video frames for searching text areas. Therefore, ants would leave pheromone in each sub-block. After the ant colony algorithm is finished, it produces a pheromone matrix. By binarizing the pheromone matrix, the text blocks can be located. The result has proved that the binarization method proposed in this paper is more accurate than otsu’s method. At last, to reduce the false detection rate, the different directions of edge intensity ratio of text areas are computed, as the real text areas’ edge intensity ratio is much smaller than the false one.
|
2022-08-27T06:21:47.257Z
|
118,949,776 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1029/GM125P0191",
"MAG": "1524159223",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Solar Energetic Particles (SEPs) produce detrimental effects on spacecraft and possibly high altitude aircraft. They represent a potential hazard for astronauts and cause the disruption of polar cap communications. They are an ionization source for the polar cap and as such should be included in ionospheric models. Finally, SEPs are an important source for the radiation belts and should be included in dynamic radiation belt models. All of these reasons imply the need for a Solar Energetic Particle model for real-time operational use. Given the flux of Solar Energetic Particles in space beyond the magnetosphere, the main parameter that describes the SEP population near the Earth is what is called the geomagnetic cutoff'. For a given latitude and local time or longitude at the Earth, the cutoff is the lowest energy (or rigidity) particle that can reach the Earth. Because magnetospheric currents have a significant effect on the cutoffs and because these external currents change significantly during a magnetospheric storm, it is necessary to calculate cutoffs for each storm and throughout the storm at a multiplicity of latitudes and local times. Geomagnetic cutoffs are traditionally calculated by tracing test particle trajectories in a model magnetic field. Cutoffs are not sharp but exhibit alternate forbidden and allowed regions. As a result, the global calculation of storm-time cutoffs is computationally intensive and if performed in traditional ways may not meet time constraints associated with real-time operations. This challenge can be met by specialized cutoff search strategies. This paper will review one effort that is underway to construct a fast, useful, solar energetic particle model.
|
2022-09-02T05:03:46.220Z
|
34,747,482 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1159/000045897",
"MAG": "2064950530",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
When the renal medulla becomes hypertonic in association with the formation of concentrated urine, the cells of the medulla avoid the stress of high intracellular salts by accumulating small non-perturbing organic osmolytes. The response has been studied in most detail in cultured kidney-derived cells, and confirmed in studies of the intact kidney. The non-perturbing osmolytes, myo-inositol, betaine, and sorbitol, are accumulated because of stimulation of the transcription of the genes for the proteins that catalyze their accumulation by transport or synthesis. The genes involved have all been cloned and sequenced and contain tonicity responsive regulatory elements (TonEs) in their 5′ region. During hypertonicity, the elements are occupied by TonE-binding protein, a transacting factor that has been cloned and characterized. Current efforts focus on identifying the mechanism by which cells sense hypertonicity and how that leads to activation of TonE-binding protein.
|
2022-09-11T05:01:49.011Z
|
154,027,599 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1287/MNSC.25.1.31",
"MAG": "1971793576",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A conceptually new first-cut decision-aid for optimal delegation is introduced. It takes a subjective approach to capital budgeting, from the delegator's perspective. A model captures the tradeoffs between the cost of centralized (duplicated) review, and the opportunity cost and risk of having (otherwise) "unacceptable" projects. Two explicit limits to optimal decentralization are identified to help headquarters (HQ) to select the kinds of proposals that should be: (a) Approved and executed by divisions without HQ review. (b) Rejected by divisions without HQ review. (c) Submitted to HQ for a centralized review. A numerical example is presented to demonstrate the process.
|
2022-09-11T15:38:40.033Z
|
43,630,138 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/PECON.2012.6450233",
"MAG": "1994426887",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper presents a new algorithm based on characteristic equation of solar cells to determine the Maximum Power Point (MPP) of PV modules under partially shaded conditions (PSC). To achieve this goal, an analytic condition is introduced to determine uniform or non-uniform atmospheric conditions quickly. This paper also proposes an effective and quick response technique to find the MPP of PV array among Global Peak (GP) and local peaks when PSC occurs based on the analytic condition. It also can perform in a manner like conventional MPPT method when the insolation conditions are uniform. In order to verify the accuracy and validity of the proposed method, different simulations are carried out in MATLAB-Simulink environment for various atmospheric conditions.
|
2022-09-15T03:42:29.458Z
|
12,264,352 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1107/S1600536810025924",
"MAG": "2918374428",
"PubMedCentral": "3007384"
},
"license": null,
"status": null,
"url": null
}
|
The title 1:1 adduct, C5H5BrN2·C7H6O3, contains two molecules of each species in the asymmetric unit, with similar geometries. In the crystal, molecules are linked to form extended chains along [100] by N—H⋯O, O—H⋯O, O—H⋯N and C—H⋯O hydrogen bonds. Adjacent chains are crosslinked via further N—H⋯O interactions into sheets lying parallel to (001). The crystal studied was an inversion twin with a 0.54 (2):0.46 (2) domain ratio.
|
2022-10-14T00:32:12.658Z
|
120,172,856 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1163/156939303772681398",
"MAG": "1965167133",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A new set of entire domain basis functions employable in the numerical solution via the Method of Moments (MoM) of the Electric Field Integral Equation (EFIE) on a metallic patch with a convex polygonal shape is presented in this paper. Such new basis functions are built by imposing both the boundary conditions for the normal component of the current density on the patch edges and other constraints coming from the physical distribution of the current on the metallization. Accuracy and fastness of common MoM procedure implemented by numerical codes based on subdomain basis functions are improved, when applied to patches with convex polygonal shape. Some numerical results are presented in order to show the capabilities of the new entire domain functions in the solution of radiation problems involving microstrip patch antennas.
|
2022-09-02T06:49:38.150Z
|
29,777,437 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1074/jbc.M114.609230",
"MAG": "2151412853",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Background: Mechanisms whereby local bone-derived factors regulate FGF-23 are unclear. Results: Low and high molecular weight FGF-2 stimulated FGF-23 promoter activity in osteoblasts through membrane FGFR-mediated PLCγ and MAPK activation of NFAT and Ets1 and integrative nuclear FGFR1 signaling involving cAMP/CBP/CREB signaling pathways, respectively. Conclusion: Membrane FGFR and intranucelar FGFR/CBP pathways regulate FGF-23 transcription. Significance: Paracrine/autocrine FGFs control hormonal FGF-23. Fibroblastic growth factor receptor 1 (FGFR1) signaling pathways are implicated in the regulation of FGF-23 gene transcription, but the molecular pathways remain poorly defined. We used low molecular weight (LMW, 18 kDa) FGF-2 and high molecular weight (HMW) FGF-2 isoforms, which, respectively, activate cell surface FGF receptors and intranuclear FGFR1, to determine the roles of membrane FGFRs and integrative nuclear FGFR1 signaling (INFS) in the regulation of FGF-23 gene transcription in osteoblasts. We found that LMW-FGF-2 induced NFAT and Ets1 binding to conserved cis-elements in the proximal FGF-23 promoter and stimulated FGF-23 promoter activity through PLCγ/calcineurin/NFAT and MAPK pathways in SaOS-2 and MC3T3-E1 osteoblasts. In contrast, HMW-FGF-2 stimulated FGF-23 promoter activity in osteoblasts through a cAMP-dependent binding of FGFR1 and cAMP-response element-binding protein (CREB) to a conserved cAMP response element (CRE) contiguous with the NFAT binding site in the FGF-23 promoter. Mutagenesis of the NFAT and CRE binding sites, respectively, inhibited the effects of LMW-FGF-2 and HMW-FGF-23 to stimulate FGF-23 promoter activity. FGF-2 activation of both membrane FGFRs and INFS-dependent FGFR1 pathways may provide a means to integrate systemic and local regulation of FGF-23 transcription under diverse physiological and pathological conditions.
|
2022-11-27T17:03:09.345Z
|
71,438,706 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1310/hpj4207-631",
"MAG": "1996419077",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Background The manufacturer of simvastatin recommends a dose limitation of 10 mg daily when used in combination with gemfibrozil, due to increased risk of myopathy and rhabdomyolysis. Little information is available regarding the risk of adverse effects of atorvastatin when used in combination with gemfibrozil. Purpose To compare the rate of discontinuation or dose reduction due to adverse effects with simvastatin and gemfibrozil versus atorvastatin and gemfibrozil. Methods Retrospective review of patients taking gemfibrozil in combination with simvastatin 10 mg, simvastatin 80 mg, or atorvastatin 40 mg for at least 6 months. Results A total of 166 patients were included; 59 were taking simvastatin 10 mg (S10), 47 were taking simvastatin 80 mg (S80), and 60 were taking atorvastatin 40 mg (A40). There was no significant difference in the rate of discontinuation or dose reduction due to adverse effects among the groups (10.2% for S10, 21.2% for S80, and 10% for A40, P = 0.159). A paired comparison of discontinuation or dose reduction due to adverse effects between the simvastatin 80 mg and atorvastatin 40 mg groups approached a trend toward a difference (P = 0.104). Severe adverse effects occurred in the simvastatin 80 mg and atorvastatin 40 mg groups. Conclusion Our results did not show a significant difference in discontinuation or dose reduction due to adverse effects between patient groups taking gemfibrozil in combination with simvastatin 10 mg, simvastatin 80 mg, or atorvastatin 40 mg. However, the rate of this outcome in the S80 group was approximately double that for the S10 and A40 groups. Further studies are needed to compare the safety of these statin-gemfibrozil combinations.
|
2022-08-25T00:33:27.962Z
|
60,535,778 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4028/www.scientific.net/AMM.513-517.763",
"MAG": "1967840193",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Discrete element softwares that have been reported at home and abroad, normally calculate with fixed mechanical models. As the development of discrete element theory, users need more different mechanical models. Based on the three dimensional discrete element software developed by our team independently, mechanical model dynamic loading module has been added, which enables the software to meet the needs for different demands, and provides convenience for further development of wider range of applications.
|
2022-12-14T01:01:52.074Z
|
25,868,482 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1074/jbc.M112.339374",
"MAG": "2059244672",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Background: Processing of HIV-1 Gag/Gag-Pro-Pol polyprotein by viral protease is an essential step to produce infectious virus particle. Results: Processing of CA/SP1, SP1/NC, and SP2/p6 sites by HIV-1 protease are affected by context. Conclusion: Complex substrate interactions beyond the active site of the enzyme define HIV-1 processing rate. Significance: This study helps to understand role of context outside cleavage sites in HIV-1 processing. Processing of the human immunodeficiency virus type 1 (HIV-1) Gag and Gag-Pro-Pol polyproteins by the HIV-1 protease (PR) is essential for the production of infectious particles. However, the determinants governing the rates of processing of these substrates are not clearly understood. We studied the effect of substrate context on processing by utilizing a novel protease assay in which a substrate containing HIV-1 matrix (MA) and the N-terminal domain of capsid (CA) is labeled with a FlAsH (fluorescein arsenical hairpin) reagent. When the seven cleavage sites within the Gag and Gag-Pro-Pol polyproteins were placed at the MA/CA site, the rates of cleavage changed dramatically compared with that of the cognate sites in the natural context reported previously. The rate of processing was affected the most for three sites: CA/spacer peptide 1 (SP1) (≈10-fold increase), SP1/nucleocapsid (NC) (≈10–30-fold decrease), and SP2/p6 (≈30-fold decrease). One of two multidrug-resistant (MDR) PR variants altered the pattern of processing rates significantly. Cleavage sites within the Pro-Pol region were cleaved in a context-independent manner, suggesting for these sites that the sequence itself was the determinant of rate. In addition, a chimera consisting of SP1/NC P4–P1 and MA/CA P1′–P4′ residues (ATIM↓PIVQ) abolished processing by wild type and MDR proteases, and the reciprocal chimera consisting of MA/CA P4–P1 and SP1/NC P1′–4′ (SQNY↓IQKG) was cleaved only by one of the MDR proteases. These results suggest that complex substrate interactions both beyond the active site of the enzyme and across the scissile bond contribute to defining the rate of processing by the HIV-1 PR.
|
2022-12-15T23:10:55.801Z
|
85,146,531 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/14772019.2010.492644",
"MAG": "2070468832",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Specimens of the paneuarthropod Campanamuta mantonae gen. et sp. nov. are described from the lower Cambrian Sirius Passet Fauna of North Greenland. It is one of the most common taxa in the present collections from the Sirius Passet Fauna, being represented by some 1700 specimens (19%) of an estimated total of perhaps 8500 fossils of the collections studied. Unusually, much internal anatomy of Campanamuta has been preserved. However, interpretation of the preserved structures has been hampered by their variable appearance in different specimens and because of the degree of compression that has occurred. This paper describes the external and internal morphology of Campanamuta, and discusses the problems involved in its reconstruction. A model for the internal architecture of the animal is proposed, which recognizes the preservation of apodemes, musculature and the gut, providing the most complete picture of the internal anatomy of any Cambrian arthropod. This morphology complements that preserved in the Chengjiang and Burgess Shale taxa and adds a new source of data for the reconstruction of basal euarthropod phylogeny.
|
2022-12-22T15:45:42.896Z
|
244,552,253 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1182/blood-2021-152993",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://doi.org/10.1182/blood-2021-152993"
}
|
Multiple myeloma is characterized by recurrent chromosomal translocations that involve the immunoglobulin gene enhancers and partners such as the cyclin D genes (CCND1, CCND2 or CCND3) or other genes like WHSC1 and MAF. t(11;14) results in upregulation of CCND1 with unique morphological, phenotypic markers, and drug sensitivity profiles with exquisite sensitivity to BCL2 inhibitors. It is evident now that this unique sensitivity profile is driven by the BH3-proapoptotic protein priming of BCL2 with high BCL2/MCL1 or BCL2/BCL2L1 ratios. However, the epigenetic mechanisms associated with t(11;14) and their impact on genes regulation and clinical response to venetoclax remains elusive. In the present study we compared the transcriptomics (scRNA-seq) and chromatin accessibility (scATAC-seq) of single plasma cells of MM patients with and without t(11;14) as well as pre- and post-venetoclax exposure in order to establish the epigenomic signature of t(11;14) and/or BCL2-sensitivity in myeloma.
Serial BM aspirates (n=24) were collected from 15 relapsed or refractory myeloma patients (RRMM); harboring t(11;14) (n=6 pairs) and 9 without this translocation prior to initiation of salvage therapy and at time of relapse. All t(11;14) MM patients were treated with venetoclax. Unbiased chromatin accessibility and mRNA profiling of CD138 pos cells were performed using the chromium single cell ATAC and RNA-Seq 3' solution (10x Genomics), respectively. Cell Ranger, Seurat and ArchR were used for sample de-multiplexing, barcode processing, single-cell 3' gene, peaks counting, and data analysis.
We first compared the scATAC-seq and scRNA-seq profiles found in CD138 pos MM cell isolated from patients harboring t(11;14) with the one obtained in patients without this translocation. As expected, t(11:14) patients had high chromatin accessibility at the CCND1 locus and high mRNA expression. Differentially accessible chromatin analysis identified 147518 peaks that were specific to t(11;14) patients. Of interest, motifs enrichment analysis of accessible peaks identified a "B cell-like" motifs signature with enriched TFs motifs such as TCF4 and PAX5 in t(11;14) patients compared to non t(11:14) enriched for IRF and STAT family of motifs. The integration of the scATAC-seq and scRNA-seq data confirmed the B cell signature of t(11;14) patients with upregulation of B cell markers such as MS4A1, VPREB3, CD79A, CD19, and down-regulation of plasma cell markers such as TDO2, EFEMP1, CD28, SLAMF7, and IL6R. Additionally, we found PAX1, PAX5, TCF3, TCF5, and SPI1 transcription factors to be highly expressed in t(11;14) while the non t(11:14) were enriched for IRF1-9 transcription factors. Of interest, the clustering analysis performed on scATAC-seq data identified 3 non t(11;14) patients with a chromatin accessibility profile similar to that of t(11;14) patients. They expressed B cell markers (PAX5, VPREB3 or FCRLA), overexpressed BCL2 and we are currently examining whether this B cell-like epigenetic signature determines sensitivity to venetoclax.
In order to define the epigenetic contribution to the acquired resistance to venetoclax in t(11;14) myeloma, we compared the chromatin accessibility profiles of t(11;14) patients pre- vs. post-venetoclax treatment. Enriched motifs within accessible peaks differed significantly between pre- and post-venetoclax with RELA, REL, RELB and EGR1 motifs predominantly enrichmed in the pre-samples in contrast to JUN, JUNB, JUND and FOSL1/L2 motifs enrichment in the post-samples. Of note, integration analysis of scRNAseq (differentially expressed genes) and ATACseq data (differentially accessible peaks) identified MCL1 and ENSA (a gene 60 Kb centromeric to MCL1 on chr1q) as the top enriched genes and peaks in resistant samples suggesting that copy number gain at the MCL1 locus (which we confirmed by single cell CNV analysis) rather than epigenetic modifications is likely the main determinant of acquired resistant to venetoclax in t(11;14) MM.
In the current study we have defined the epigenetic regulome and transcriptome associated with t(11;14) myeloma and its relatedness to B cell rather than plasma cell biology. Our studies also suggest that acquired resistance to venetoclax is largely driven by copy number gain at the MCL1 locus.
Bahlis: Karyopharm: Consultancy, Honoraria; Amgen: Consultancy, Honoraria; Takeda: Consultancy, Honoraria; Sanofi: Consultancy, Honoraria; Abbvie: Consultancy, Honoraria; Janssen: Consultancy, Honoraria; BMS/Celgene: Consultancy, Honoraria; GlaxoSmithKline: Consultancy, Honoraria; Genentech: Consultancy; Pfizer: Consultancy, Honoraria. Neri: BMS: Consultancy, Honoraria; Janssen: Consultancy, Honoraria; Sanofi: Consultancy, Honoraria; Amgen: Consultancy, Honoraria.
|
2022-01-22T04:22:38.477Z
|
146,518,520 |
{
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"DOI": "10.1056/WH200010300000002",
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},
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"url": null
}
|
Anecdotal reports have suggested that premenstrual symptoms and syndromes have deleterious effects on social and occupational functioning, but
|
2022-02-09T05:53:01.187Z
|
119,073,713 |
{
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"DOI": "10.1063/1.33800",
"MAG": "1671105258",
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},
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"status": null,
"url": null
}
|
It is shown that optical elements placed at interference minima of a radiation field will damage less. For example, when a 103⋅ A (or 3.15⋅103 A) thick metallic foil is placed at the node of a standing wave pattern produced by 30 μm wavelength radiation polarized parallel to the foil surface, the damage due to Joule heating is calculated to decrease by a factor 6.8⋅103 (6.8⋅104). When the angle of incidence is θ=5.7⋅ and the wave is polarized parallel to the plane of incidence, the factor is 5.8⋅102 (1.8°103). Thus, higher fields are possible near mirrors, without damage. Applying this phenomenon to laser template accelerator design allows ≊ 1GeV/m acceleration at any (including very high) particle energy. Experiments could determine how much of the calculated increase can be realized and where and if other damage mechanisms may take over.
|
2022-02-09T22:40:33.043Z
|
90,352,219 |
{
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"DOI": "10.13343/J.CNKI.WSXB.20170257",
"MAG": "2808420908",
"PubMedCentral": null
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"license": null,
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|
目的本实验室前期研究发现水稻条斑病菌（Xanthomonas oryzae pv.oryzicola，Xoc）RS105菌株中pilT基因Tn5转座子插入突变体在寄主水稻上致病性明显降低，在非寄主烟草上激发过敏反应（hypersensitive response，HR）的能力也明显减弱。为了揭示pilT基因在Xoc菌株中的功能，本文进行了深入研究。 方法本实验通过无标记双交换敲除的方法获得Xoc RS105菌株pilT基因缺失突变体RΔpilT，并对该突变体的游动性以及生物膜等表型进行了检测。 结果与野生型RS105菌株相比，敲除突变体RΔpilT不仅在感病水稻IR24上的致病性显著降低，在非寄主烟草上产生过敏反应的能力减弱，而且突变体游动性降低，生物膜含量增加，互补子能够恢复上述缺陷至野生型水平。qRT-PCR结果显示，在RΔpilT中，hrpG、hrpX、hrcC、clp、rpfG、pilA、pilC基因表达量明显降低。 结论Xoc中pilT为重要的毒性相关基因，其致病性与游动性和生物膜含量变化相关，并且受clp、rpfG、pilA、pilC等基因调控。pilT基因编码的PilT蛋白是构成Ⅳ型菌毛的亚基之一，为菌体运动提供能量。本文对pilT基因的功能研究，为进一步分析Ⅳ型菌毛在Xoc中的功能提供了线索。
|
2022-02-10T19:00:31.756Z
|
35,845,654 |
{
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"DOI": "10.1109/INTEE.2015.7416795",
"MAG": "2292032631",
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"license": null,
"status": null,
"url": null
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|
In this paper, we are interested in localizing acoustic sources such as gunfire of Automatic Pistol (AP) and Kalashnikov AK-47 via the Imote2 wireless sensor node platform, using an array of four synchronized microphones connected to ITS400 sensor board of Imote2. More particularly, this work concerns the implementation of a localization algorithm based on the TDOA (Time Difference of Arrival) between the acquired signals by the microphones. This work can be divided into two parts. The first part is dedicated to the realization of an Imote2-based platform, which allows the acquisition of acoustic signals. In the second part, we have evaluated the performance of relative TOA (Time of Arrival) estimation algorithms, where CA-CFAR (Cell Averaging Constant False Alarm Rate) algorithm gave the best results.
|
2022-02-12T08:08:11.928Z
|
248,042,001 |
{
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"DOI": "10.33024/jkpm.v5i4.4937",
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},
"license": null,
"status": "BRONZE",
"url": "http://ejurnalmalahayati.ac.id/index.php/kreativitas/article/download/4937/pdf"
}
|
ABSTRAK Permasalahan gizi banyak dijumpai pada usia remaja, diantaranya gizi lebih, obesitas, gizi kurang, anemia, pola makan yang salah dan sebagainya. Data Kecamatan Kalianda memiliki prevalensi 1,2% sangat kurus, 8,9% kurus, 88,5 normal, dan 1,4% gemuk. SMK Hampar Baiduri Kalianda dapatkan dari 125 siswi diketahui 47,2% remaja putri berstatus gizi kurus, 30,4% berstatus gizi normal, dan 22,4% remaja putri berstatus gizi overweight, informasi bahwa delapan siswi dari sepuluh orang siswa sulit menerima kondisi tubuh mereka. Tujuan penelitian diketahui Pengaruh Pendidikan Gizi Terhadap Pengetahuan Dan Sikap Pola Makan Serta Body Image Pada Siswa Remaja Di SMK Hampar Baiduri Kalianda Tahun 2021. Penelitian ini menggunakan jenis metode pendekatan one group pretest-posttest, kegiatan ini telah di lakukan di SMK Hampar Baiduri Kalianda pada bulan Mei-Juni tahun 2021. Jumlah peserta adalah 33 orang. Pengumpulan data menggunakan kuesioner. Diketahui rata-rata pengetahuan sebelum diberikan pendidikan kesehatan adalah 59,90 dan sesudah adalah 83,07. Rata-rata sikap sebelum diberikan pendidikan kesehatan adalah 51,84 sikap sesudah adalah 72,50. Rata-rata body image sebelum diberikan pendidikan kesehatan adalah 34,35 dan body image sesudah adalah 50,16. Saran Pihak sekolah bekerja sama dengan instansi kesehatan terkait misalnya Puskesmas untuk memberikan penyuluhan tentang gizi dan kesehatan khususnya tentang faktor-faktor yang berhubungan dengan status gizi bagi siswi SMK Hampar Baiduri. Kata Kunci: Pengetahuan, Sikap Pola Makan, Body Image, Siswa Remaja, Pendidikan Kesehatan ABSTRACT Nutritional problems that are often encountered in adolescents include overnutrition, obesity, malnutrition, anemia, wrong diet, and so on. Data from Kalianda Regency has a prevalence of 1.2% very thin, 8.9% thin, 88.5 normal, and 1.4% obese. Hampar Baiduri Kalianda Vocational School was obtained from 125 students, it was known that 47.2% of adolescent girls were undernourished, 30.4% had normal nutritional status, and 22.4% of adolescent girls were overweight, information that eight students out of ten students found it difficult to accept their body condition. they. The purpose of the study was to determine the effect of nutrition education on knowledge and attitudes towards diet and body image among adolescent students of SMK Hampar Baiduri Kalianda in 2021. This study used a one-group pretest-posttest approach, this activity was carried out at SMK Hampar Baiduri Kalianda in May -June 2021. The number of participants is 33 people. Collecting data using a questionnaire. It is known that the average knowledge before being given health education is 59.90 and after it is 83.07. The average attitude before being given health education was 51.84 the attitude after that was 72.50. The average body image before being given health education was 34.35 and after body image was 50.16. Suggestions The school cooperates with related health offices such as the Puskesmas to provide counseling about nutrition and health, especially about factors related to nutritional status for students of SMK Hampar Baiduri. Keywords: Knowledge, Attitude of Eating Patterns, Body Image, Adolescent Students, Health Education
|
2022-04-15T00:29:48.640Z
|
236,341,901 |
{
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"DOI": "10.1200/JCO.2021.39.15_SUPPL.1561",
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"license": null,
"status": null,
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|
1561 Background: Surgical interventions are studied less often than medical or radiation interventions in oncology clinical trials. We characterized surgical oncology trials registered on ClinicalTrials.gov, analyzed funding sources and identified features associated with early discontinuation and results reporting. Methods: We employed a cross-sectional study design with descriptive, logistic regression, cox regression, time series and survival analyses. We downloaded all 270,172 studies registered on the Aggregate Analysis of the ClinicalTrials.gov database from October 1, 2008 to March 9, 2020. After excluding non-interventional trials, applying cancer/oncology specific Medical Subject Heading terms to the remaining trials and excluding phase 1 trials, 27,915 trials were identified for manual review. Primary exposure variables were trial focus: neoplasia site and treatment modality (surgical interventions included investigations of outcomes from surgical resection or intra-operative/peri-operative changes), and funding: industry, U.S. government, academic. Results: 26,815 trials were found to have true oncology content; 1,661 (6.2%) involved surgical oncology, representing 311,789 patients. Funding sources were: 82.7% by academic institutions, 10.9% by industry, and 6.2% by U.S. government. The most studied neoplasia sites were colorectal (17.4% of trials), breast (10.7%), gastric (10.5%), hepatic (8.6%), lung (7.5%), brain/CNS (6.7%) and cervical (6.6%). U.S. government funded surgical oncology trials had the lowest risk of early discontinuation (adjusted HR 0.65, 95% CI: 0.58-0.73, p<0.001) and the highest odds of results reporting (adjusted OR 1.35, 95% CI: 1.08-1.68, p=0.008) (Table). Conclusions: There is a paucity of surgical oncology clinical trials compared to other treatment modalities, especially in context of surgery’s role in overall cancer care. From 2008-2020 only 6.2% of trials focused on surgical oncology, and U.S. government funded trials displayed the lowest hazard of early discontinuation and highest odds of results reporting. Stakeholders should look to government funded trials as models of improvement, but must increase representation and results dissemination of surgical oncology trials to guide treatment recommendations. Surgical oncology trial features and associated early discontinuation/results reporting.[Table: see text]
|
2022-01-27T01:42:51.484Z
|
142,313,133 |
{
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"ArXiv": null,
"DOI": "10.1111/weng.12332",
"MAG": "562937169",
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"status": null,
"url": null
}
|
PART I: THE FIRST DIMENSION OF COMMUNICATION ACROSS CULTURES: DIFFERENT VOICES Leading and Motivating Across Cultures Like and Unlike: Different Communication Styles Noise and Silence: Verbal and Non-verbal Communication PART II: THE SECOND DIMENSION: COMMUNICATION AT WORK The Micro-Environment of Diversity at Work: Gender Factors and Minority Roles in Workplace Communication 'I Don't Like It Here': Culture Shock and Adjustment Learning and Teaching Across Cultures PART III: THE THIRD DIMENSION: GOING GLOBAL Command and Control: International Negotiations and Alliances Communication Webs and Organisational Networks PART IV: THE FOURTH DIMENSION: COMMUNICATION MEDIA Voices in Cyberspace: Messages by Mass Media Actions Speak Louder Than Words: Ethical Behaviour, Social Responsibility and Protecting the Environment
|
2022-07-25T15:33:08.826Z
|
216,314,793 |
{
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"ArXiv": null,
"DOI": "10.1111/iere.12452",
"MAG": "3010708032",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We study a one‐to‐many bargaining model in which one active player bargains with every passive player on how to share the surplus of a joint project. The order of bargaining is not fixed and the active player decides whom to bargain with in each period. Our model admits a rich set of equilibria and we identify the upper and lower bounds of equilibrium payoffs. We also examine whether two natural ordering protocols often assumed in existing studies can sustain endogenously. Although the queuing protocol may indeed arise in an equilibrium, the rotating protocol is in general not self‐enforcing.
|
2022-09-02T15:08:04.720Z
|
21,974,281 |
{
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"DOI": "10.1109/TMAG.2007.892437",
"MAG": "2102314008",
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},
"license": null,
"status": null,
"url": null
}
|
We propose an efficient geometric multigrid (GMG) strategy for finite element (FE) meshes of non-uniform refinement levels. The suggested method exploits that levels of high resolution usually extend over small sub-domains only. By restricting all fine level smoothing operations to the corresponding partial meshes, memory consumption and operation count are kept at a minimum
|
2022-09-13T10:45:35.317Z
|
237,496,993 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.23880/ipcm-16000198",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://doi.org/10.23880/ipcm-16000198"
}
|
Nephrotoxicity is common side effect of many drugs like anticancer, aminoglycoside antibiotic and radioactive compounds. In allopathy there is no effective treatment for the cure of kidney diseases. Aerva javanica, Ocimum basilicum and Kalanchoe pinnata are nephroprotective plant to treat various kidney diseases. This experiment was aimed to evaluate nephroprotective activity of above plants on Vero cell line. Optimization of dose of Cisplatin was done using MTT assay against Vero cell line upto 50% of cytotoxicity. Optimized concentration of Cisplatin was further used for the treatment of different extracts of Aerva javanica, Ocimum basilicum and Kalanchoe pinnata against Vero cell line individually. Full factorial design was performed to develop eight different combinations of extracts of selected plants. They were evaluated using MTT cell viability assay. The 50 μg/ml dose of Cisplatin was found to produce upto 50% of cell cytotoxicity. In the treatment model, % inhibition of Aerva javanica and Kalanchoe pinnata plant extracts at dose level 250 and 500 μg/ml were found more effective than Ocimum basilicum when compared with Cisplatin. In the treatment model, % inhibition of combination formula no. 3, 4 and 7 were found significant effective than other combinations with compared to Cisplatin. These experiments showed the plant Aerva javanica was most active than other two selected plants by using Cisplatin against Vero cell line. The combination of plants Aerva javanica and Kalanchoe pinnate were shows better effect at dose level 500 and 100 μg/ml compared to other combinations.
|
2022-09-23T01:01:01.428Z
|
252,903,985 |
{
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"ArXiv": null,
"DOI": "10.1200/OP.22.00280",
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"license": null,
"status": null,
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|
PURPOSE
Comprehensive health care centers are increasingly popular as they offer inclusive health care services under one roof. Often, these centers are formed by merging previously separate clinics. However, there is a lack of systematic guidance on the interprofessional, and interteam and intrateam dynamics that may develop during such an organizational change process. Using team process literature, we identify a possible model to explain how merging into a comprehensive cancer center (CCC) might influence health care teams and their subsequent outcomes, including patient experience.
METHODS
We used a mixed-method research design. Qualitative data were collected via semistructured interviews from 20 health care professionals employed at a recently merged CCC. During the time frame the interviews were collected, quantitative data were collected from 50 patients receiving treatment at the cancer center through anonymous paper-pencil surveys. Qualitative interviews were analyzed using thematic analysis, on the basis of the input-process-output team dynamics framework. Descriptive statistics were calculated for patient experience data. Trends between data collections were identified.
RESULTS
On the basis of our qualitative analysis, we provide an input-process-output framework that documents positive and negative aspects of interteam and intrateam dynamics associated with the merger process. Additionally, a number of connections were found between health care professional perceptions and quality patient experiences (eg, merger impacts on interteam and patient communication).
CONCLUSION
Our findings and model may assist in future merging efforts. Future CCCs may use the proposed framework to better understand and visualize their postmerger progress, in particular from the aspects of interprofessional, and interteam and intrateam dynamics.
|
2022-10-18T18:11:43.708Z
|
219,330,802 |
{
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"ArXiv": null,
"DOI": "10.1002/cplu.202000307",
"MAG": "3025054004",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The hetero-tetranuclear Cu2+ /Ca2+ /Ca2+ /Cu2+ complex obtained with the N,N'-bis((3-hydroxy-4-pyron-2-yl)methyl)-N,N'-dimethylethylendiamine (Malten) ligand has been studied in solid and solution states as scaffold to bind anions. Three crystal structures showing the same metal ions sequence have been examined; they display a tetracharged complex cation neutralized by four monocharged anions. The anions play two different roles: as coordinated (two ClO4 - , Cl- or NO3 - ) or ancillary (two ClO4 - ) guests. The tetranuclear scaffold hosts two anions also in aqueous and ethanol solutions. Spectrophotometric studies in ethanol allowed to determine the addition constant values for Cl- and Br- (Log K1-2 =4.43(4), 4.39(3) for Cl- , 3.80(3), 3.54(2) for Br- ) while the others, although bound, showed lower affinity for the scaffold. Both the crystals and the solutions change their color depending on the added anion, namely pink, dark green or blue in the presence of ClO4 - , Cl- or NO3 - , respectively, thus the presence of the different anions is visible to the naked eye. The hetero-tetranuclear Cu2+ /Ca2+ /Ca2+ /Cu2+ complex is a versatile architecture to be used as scaffold for anion binding.
|
2022-12-10T04:36:51.319Z
|
8,019,026 |
{
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"ArXiv": null,
"DOI": "10.1177/000992280104000604",
"MAG": "2156653556",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Objectives: A recent patient series reported the incidental findings of improved social and language skills in 3 children with autistic spectrum disorders after the administration of secretin, a peptide hormone. However, a subsequent study did not find evidence for a drug effect. Parents are seeking treatment with secretin despite the absence of empirical investigations demonstrating amelioration in autism symptomology. In order to more precisely measure the effects of secretin, this study investigated the effect of a single intravenous dose of porcine secretin on 12 autistic children through a randomized, double-blind, placebo-controlled, crossover study. Children were assessed on objective language and on social, neuropsychological, and gastrointestinal measures to evaluate drug effects. The study was conducted over a 16-week trial. The results indicated that significant differences were not observed on the majority of the dependent variables. Statistically significant differences were observed on measures of positive affect and activity level following secretin infusion. In general, the autistic children did not demonstrate the improvements described in the initial retrospective report.
|
2022-12-11T19:11:20.993Z
|
28,055,756 |
{
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"ArXiv": null,
"DOI": "10.1523/JNEUROSCI.20-13-j0002.2000",
"MAG": "2100029555",
"PubMedCentral": null
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"license": null,
"status": null,
"url": null
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|
PAS (PER, ARNT, SIM) proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. In an attempt to better understand how organisms sense environmental changes, we have characterized a novel member of the PAS superfamily, MOP9 (member of PAS superfamily), that maps to human chromosome 12p11.22-11.23. This protein displays significant homology to the Drosophila circadian factor CYCLE and its putative mammalian ortholog MOP3/bMAL1. Like its homologs, MOP9 forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. In a manner consistent with its role as a biologically relevant partner of these proteins, MOP9 is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Importantly, MOP9 is coexpressed with CLOCK in the suprachiasmatic nucleus, the site of the master circadian oscillator in mammals.
|
2022-12-19T03:22:50.549Z
|
99,842,924 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1039/C6CE01203E",
"MAG": "2460183158",
"PubMedCentral": null
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"license": null,
"status": null,
"url": null
}
|
Non-toxic and earth-abundant pyrite (FeS2) is a promising photoelectric material for solar energy conversion and storage. In this study, an efficient FeS precursor was employed to synthesise successfully various shapes of pyrite FeS2, such as nanopolyhedra, nanocubes, nanooctahedra, and irregular nanocrystals via a simple hydrothermal method by adjusting the reaction conditions. Pyrite FeS2 nanopolyhedra and nanocubes were synthesised using the FeS precursor as the single iron source and thiourea (NH2CSNH2) as the sulphur source at various reaction temperatures. Nanooctahedra and irregular nanocrystals were obtained using sodium thiosulfate pentahydrate (Na2S2O3·5H2O) and sulphur powder as sulphur sources. The effects of polyvinylpyrrolidone content and the molar ratio of the FeS precursor to NH2CSNH2 on the formation of cubic shaped pyrite FeS2 were investigated. The products were characterised by X-ray diffraction, scanning electron microscopy, energy-dispersive spectroscopy, transmission electron spectroscopy, X-ray photoelectron spectroscopy, and ultraviolet–visible and Raman spectroscopy. The proposed facile hydrothermal method used an efficient FeS precursor as the iron source, which can be easily controlled to produce high-purity pyrite FeS2 with desirable optical absorption properties.
|
2022-12-24T18:22:30.975Z
|
138,649,319 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1533/9781845698881.107",
"MAG": "2499265784",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Publisher Summary Aluminum process pipework covers a wide spectrum of materials, tube diameters, and wall thicknesses depending upon specific requirements. These can range from the pure Al 1100 series through the Al-Mn 300 series up to the hardenable 6OOO series. However, application is generally limited to the non-heat treatable high strength AI-Mg 5000 series. Physical pipe sizes can range from 6.3mm Nominal Bore (NB) up to 500mm OD over a wide range of wall thicknesses; diameters above 500mm OD are not commercially available and, if required, must be fabricated from rolled plate. Welding techniques for aluminum are currently limited to conventional MIG and TIG processes, which, although effective, have seen significant changes over the previous two decades. This chapter clarifies some of the problems associated with aluminum pipewelding and by examination of these, offers solutions in terms of joint configuration, filler wire, cleanness, and welding process. Advanced welding processes are also discussed with particular regard for automatic orbital pipewelding techniques.
|
2022-02-09T09:58:56.154Z
|
242,713,025 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.32920/ryerson.14644059",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://rshare.library.ryerson.ca/articles/thesis/Fabrication_of_smart_titanium_implants_by_femtosecond_laser_synthesis_/14644059/1/files/28122354.pdf"
}
|
A 3-D nanostructure particle network of TiO2, TiO, Ti3O oxide nanoparticles is synthesized by ultra-short pulsed femtosecond laser irradiation from a Grade 2 pure titanium substrate. This study investigated the properties of the resulting nanostructure and underneath phase transformed surface for biomaterial applications. Controlled tuning of surface chemistry and phases of the 3-D network were found to directly influence the cell mobility. The presented findings support a previously unrealized capacity by nano-core shell like particles and its phases for reducing cell proliferation on a biomaterial. Both osteoblast and fibroblast cells improved controllability and anisotropic migration with the developed nanostructure. The corresponding oxide phases which influenced this controllability was analysed in detail with possible potential in health care industry. The results suggest an effective means to improve biomaterial life thereby increasing implant life.
|
2022-07-09T05:11:12.778Z
|
250,268,779 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.56042/ijeb.v58i12.44588",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBYNCND",
"status": "GOLD",
"url": "https://doi.org/10.56042/ijeb.v58i12.44588"
}
|
Bioethanol has been a focus of researchers as alternate green fuel. Agro residues could be a promising resource for bioechanol production. In this study, we explored the potential of these fruit wastes to produce total reducing sugars (TRS), pentose sugars (PS) and bioethanol.. For this purpose, fruit wastes (pineapple, cashew fruit and plantain peels) were taken as a substrate with the use of microorganism Saccharomyces cerevisiae . The conversion of fruits wastes were carried out via acid hydrolysis, which yielded fermentable sugar. The results showed that the ethanol production rate through fermentation of fruit waste yields was optimal at pH 5.5, temperature 32°C, specific gravity 0.865 and a concentration of about 6.10%. For viability of producing ethanol in large quantities and reasonable costs, we did optimization of various physicochemical parameters viz. pH, temperature and specific gravity. The waste materials after fermentation serve as soil fertilizer.
|
2022-08-26T14:00:57.185Z
|
252,052,942 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.46443/catyp.v18i1.303",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBYNCND",
"status": "GOLD",
"url": "https://cienciasadmvastyp.uat.edu.mx/index.php/ACACIA/article/download/303/343"
}
|
El artículo examina, con datos del segundo trimestre del 2019, los determinantes de la probabilidad de tener un empleo de calidad en las seis entidades que componen la frontera norte de México. Para tal fin se estimaron modelos probit en los cuales la variable dependiente fue el empleo de calidad y las independientes la escolaridad, sexo, estado civil y experiencia del trabajador, así como el tamaño de la unidad económica, tipo de localidad y sector de actividad. Un resultado que destaca es que, en cinco de los seis estados fronterizos analizados, la variable más importante para obtener un empleo de calidad es el tamaño de la unidad económica. Los hallazgos están limitados por la temporalidad de la información utilizada; sin embargo, resultan originales, contribuyen a la literatura existente y pueden tomarse en cuenta para elaborar políticas públicas encaminadas a crear trabajos de calidad en la región objeto de estudio.
|
2022-09-09T05:01:28.131Z
|
162,497,716 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.7202/301197AR",
"MAG": "2143137663",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Si l'on definit le bilingue comme une personne qui se sert de deux ou de plusieurs langues (ou dialectes) dans la vie de tous les jours, alors la plupart des sourds, qui font regulierement usage de la langue des signes et de la langue majoritaire (dans sa forme ecrite, par exemple), sont bilingues. Les sourds bilingues partagent de nombreuses ressemblances avec les entendants bilingues fleur diversite, la perception qu'ils ont de leur propre bilinguisme, l'usage de divers modes de communication, etc.), mais ils possedent aussi leurs propres specificites (le manque de reconnaissance de leur statut de bilingue, le maintien de leurs deux langues, le niveau atteint dans certaines competences linguistiques, etc.). En ce qui concerne la personne biculturelle, definie comme etant celle qui participe a la vie de deux ou plusieurs cultures, qui s'adapte a l'une et a l'autre, et qui combine et synthetise certains traits de chacune d'elles, il semble evident que de nombreux sourds sont egalement biculturels. Dans cet article, nous decrirons le bilinguisme et le biculturalisme des personnes sourdes et indiquerons quelques implications qui en decoulent au plan de l'education des enfants sourds.
|
2022-09-10T06:39:12.063Z
|
253,839,397 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/09564624221138351",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
INTRODUCTION
Condylomata acuminata (CA) is a sexually transmitted infection with a high prevalence associated with psychosexual morbidity in both men and women of various age. Up to now, treatment modalities yield low clearance and recurrence rate (RR) and are also deemed low quality evidence-wise. Photodynamic therapy (PDT) is a novel and promising therapy to effectively cure and prevent CA recurrence.
METHOD
This systematic review was reported according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) and registered to the International Prospective Register of Systematic Review (PROSPERO) (CRD42022332760).
RESULTS
Ten studies were included in this systematic review. A significant value of complete response (CR) ranging from 63-100% in patients with genital warts after receiving several sessions of PDT. A relatively low recurrence rate was seen in all 10 studies, with an RR of less than 17%. Quality assessment of included studies reported mostly high-quality research.
CONCLUSIONS
PDT therapy resulted in a higher CR with significantly lower RR compared to other therapies. Thus, PDT can be an alternative treatment of CA with low RR and minimal side effects. Additional research, especially randomized clinical trials in various countries, is needed to further substantiate this treatment and formulate definitive protocols.
|
2022-11-26T17:50:18.305Z
|
134,170,905 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1557/PROC-50-411",
"MAG": "5203931",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Iron canisters for high level nuclear waste embedded in compacted bentonite in deep geologic repositories will corrode forming hydrogen gas. The equilibrium pressure (when corrosion would stop) has been estimated to be between 500 and 1000 atm. under repository conditions. As this is much higher than the lithostatic pressure (weight of rock overburden) the gas must be allowed to escape before it disrupts the repository. Escape by diffusion alone is not sufficient but recent experiments have demonstrated that the larger pores in the bentonite are blown free of water and let the gas escape before excessive pressures build up. The potential effect of a capillary breaking layer (CBL) has been explored. A fine layer nearest the canister (e.q. quartz sand) would have much lower capillary suction pressures than the bentonite clay and would keep the water out as long as there is sufficient overpressure. As long as the CBL is void of liquid water no radionuclides can escape, even if the canister is penetrated.
|
2022-11-12T03:35:54.790Z
|
209,568,798 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2210/PDB4C9P/PDB",
"MAG": "2978070005",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Cytochromes P450 catalyze a variety of monooxygenase reactions that require electron transfer from redox partners. P450cam, a soluble bacterial cytochrome from Pseudomonas putida that hydroxylates camphor, has served as the primary model to address questions on the detailed mechanisms of electron transfer and O2 activation. The entire P450cam system consists of an iron-sulfur ferredoxin, putdiaredoxin (Pdx), that transfers electrons from the FAD protein, putidaredoxin reductase (Pdr), to P450cam. P450cam is unusual in having a strict and specific requirement for Pdx as an electron donor, which suggests that the specificity for Pdx is related to the Pdx-induced structural change required for oxygen activation.1–3 The recent P450cam-Pdx crystal and NMR structures4,5 indicate that the effector role of Pdx is to shift P450cam toward the open conformation, which enables the establishment of a water-mediated H-bonded network that is required for proton-coupled electron transfer and oxygen activation.5 Pdx binding has been proposed to free the critical residue, Asp251, from salt bridging interactions with Arg186 and Lys178 in order to serve its catalytic function6,7 in shuttling protons to dioxygen.
CYP101D1 is a close homolog to P450cam and catalyzes exactly the same camphor hydroxylation reaction, uses a similar ferredoxin (Arx) and ferredoxin reductase (Adr), but exhibits subtle and possibly important differences.8 Adjacent to the heme iron ligand, Cys357, is Leu358 in P450cam while this residue is Ala in CYP101D1. Leu358 plays a role in binding of the P450cam redox partner, putidaredoxin (Pdx).9 On the opposite side of the heme about 15 – 20 A away the critical residue Asp251 in P450cam forms strong ion pairs with Arg186 and Lys178. In CYP101D1 a Gly replaces Lys178. Thus, the local electrostatic environment and ion pairing is substantially different in CYP101D1. Another important difference relates to the effect of K+ ions on substrate binding and spin state. Potassium ions promote both susbtrate binding and high-spin P450cam.10 P450cam has a K+ binding site near Tyr96 whose side chain OH group H-bonds with the camphor carbonyl oxygen of camphor so K+ helps to stabilize key substrate-protein interactions.11 CYP101D1 lacks this K+ binding site and K+ has only a modest effect on the fraction of high-spin CYP101D1.8 The addition of 200 mM KCl to the CYP101D1-camphor complex increases the spin state from 30% to only 40%.8 In our recent study aimed at comparing these two enzymes, these sites were systematically mutated in P450cam to the corresponding residues in CYP101D1.12 The data show that although individually the mutants have little effect on activity or structure, in combination there is a major drop in enzyme activity due the mutants being locked in the low-spin state thus preventing electron transfer from the P450cam redox partner, Pdx. Overall these results illustrate the delicate balance between the open and closed conformational states13 as well as a strong structural connection between the Pdx binding site (Leu358) and the region around Asp251 that undergoes a large structural change in the open/closed transition in P450cam. The results along with some structural and biochemical studies on CYP101D1 indicate that these complex interactions between spin-state, redox partner binding, and conformational changes might be less stringent or different in CYP101D1 primarily because this P450 is predominantly low-spin even in the presence of substrate14 but still is as active as P450cam. This opens up some interesting questions on how two such similar P450s can behave so differently and what, if any, the connection is between these various levels of conformational dynamics, activity, and biological function. Here we present the crystal structures of cyanide and camphor bound complexes of wild type CYP101D1 and its active site mutants, D259N and T260A, and enzyme activities. Since CYP101D1 is so similar to P450cam, a comparison of the two with respect to redox partner specificity has also been addressed to better understand whether the effector/allosteric role of redox partner binding is a general property of P450s or is unique to P450cam.
|
2022-01-27T08:30:18.473Z
|
97,883,805 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1139/V87-117",
"MAG": "2044778592",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Reaction of 8-aminoquinoline with pyridine-2-carboxaldehyde (2), pyridine-3-carboxaldehyde (3), pyridine-4-carboxaldehyde (4), and benzaldehyde (5) yields the corresponding aminals or Schiff's bases according to reaction conditions; analogous results are obtained from the reaction of 1-amino-naphtalene with pyridine-2-carboxaldehyde (6). On the other hand, reaction of 8-aminoquinoline with thiophene-2-carboxaldehyde or pyrrole-2-carboxaldehyde yields neither the aminal nor the Schiff's base. Crystals of 4 (C24H19N5) belong to the triclinic space group . Cell dimensions are a = 11.547(3), b = 11.759(2), c = 15.687(5) A, α = 98.50(2)°, β = 101.61(2)°, γ = 107.28(2)°, V = 1942.6(9) A3. Final R = 0.077 and Rw = 0.064; 3160 reflections were observed. The ir, 1H nmr of 2–6, the mass spectra of 4 and 5 and the X-ray analysis of 4 are described and discussed. Preparative features, ir, 1H nmr, analyses and crystal structure indicate that the formation of 2–6 are governed mainly by the nucleophilicity at the aldehy...
|
2022-07-04T17:06:02.211Z
|
35,971,177 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/SICE.2006.315541",
"MAG": "2110486264",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Steer-by-wire system, in which the conventional mechanical linkages between the steering wheel and the front wheel are removed, is suited to active steering control, improving vehicle stability, dynamics and maneuverability, as well as to autonomous steering control to assist the driver. Conventional controller for SBW system is designed by general feedback control method. However, driver can not exactly feel reaction torque generated from tire. And SBW system has another important problem about fault tolerant function. In this paper, we propose the bilateral control method based on the disturbance observer to improve steering feeling and the design of the sensor fault detection for SBW vehicles using sliding mode observer
|
2022-08-26T09:48:55.120Z
|
225,438,679 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1175/jhm-d-19-0095.1",
"MAG": "3049703088",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://journals.ametsoc.org/downloadpdf/journals/hydr/21/11/JHM-D-19-0095.1.pdf"
}
|
We present a comprehensive global evaluation of monthly precipitation and temperature forecasts from 16 seasonal forecasting models within the NMME Phase-1 system, using Multi-Source Weighted-Ensemble Precipitation version 2 (MSWEP-V2; precipitation) and Climate Research Unit TS4.01 (CRU-TS4.01; temperature) data as reference. We first assessed the forecast skill for lead times of 1–8 months using Kling–Gupta efficiency (KGE), an objective performance metric combining correlation, bias, and variability. Next, we carried out an empirical orthogonal function (EOF) analysis to compare the spatiotemporal variability structures of the forecasts. We found that, in most cases, precipitation skill was highest during the first lead time (i.e., forecast in the month of initialization) and rapidly dropped thereafter, while temperature skill was much higher overall and better retained at higher lead times, which is indicative of stronger temporal persistence. Based on a comprehensive assessment over 21 regions and four seasons, we found that the skill showed strong regional and seasonal dependencies. Some tropical regions, such as the Amazon and Southeast Asia, showed high skill even at longer lead times for both precipitation and temperature. Rainy seasons were generally associated with high precipitation skill, while during winter, temperature skill was low. Overall, precipitation forecast skill was highest for the NASA, NCEP, CMC, and GFDL models, and for temperature, the NASA, CFSv2, COLA, and CMC models performed the best. The spatiotemporal variability structures were better captured for precipitation than temperature. The simple forecast averaging did not produce noticeably better results, emphasizing the need for more advanced weight-based averaging schemes.
|
2022-10-01T17:15:22.928Z
|
237,093,141 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/neuros/nyab299",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Tinnitus is an abnormal perception of a sound without external stimulation. Venous pulsatile tinnitus (VPT) is a specific form of tinnitus characterized by an objective and often subjective bruit that occurs as a result of localized venous abnormalities. Clinical evaluation relies on sound quality, duration, and precipitating factors. Idiopathic intracranial hypertension (IIH) and transverse sinus stenosis (TSS) are among the most common causes of VPT. Other causes include sigmoid sinus wall abnormalities (SSWAs), jugular vein anomalies (JVAs), and emissary veins anomalies. These anomalies can be detected on magnetic resonance imaging, magnetic resonance angiography/magnetic resonance venography, and high-resolution temporal bone computed tomography. The pathogenesis behind the VPT includes turbulent blood flow as a result of luminal stenosis or abnormal dilation, amplification of internal sound due to temporal bone defects, and abnormal position of the venous sinus system structures adjacent to the bony structures of the auditive apparatus. Based on these theories, different interventional treatment modalities can be applied to treat the underlying causes. Endovascular treatments have shown high efficacy and safety among those treatments which include stenting of the lateral sinus stenosis in IIH and TSS, coiling of the SSWA and JVA, and embolization of emissary veins anomalies. Further studies are needed to understand the natural history of these anomalies and the efficacy of treatments of VPT, which-unlike other types of tinnitus-can be cured with proper treatment.
|
2022-10-18T18:52:21.505Z
|
233,982,719 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/15389588.2021.1914837",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://scholarlypublications.universiteitleiden.nl/access/item%3A3249268/view"
}
|
Abstract Objective Sleep deprivation is known to affect driving behavior and may lead to serious car accidents similar to the effects from e.g., alcohol. In a previous study, we have demonstrated that the use of machine learning techniques allows adequate characterization of abnormal driving behavior after alprazolam and/or alcohol intake. In the present study, we extend this approach to sleep deprivation and test the model for characterization of new interventions. We aimed to classify abnormal driving behavior after sleep deprivation, and, by using a machine learning model, we tested if this model could also pick up abnormal driving behavior resulting from other interventions. Methods Data were collected during a previous study, in which 24 subjects were tested after being sleep-deprived and after a well-rested night. Features were calculated from several driving parameters, such as the lateral position, speed of the car, and steering speed. In the present study, we used a gradient boosting model to classify sleep deprivation. The model was validated using a 5-fold cross validation technique. Next, probability scores were used to identify the overlap of driving behavior after sleep deprivation and driving behavior affected by other interventions. In the current study alprazolam, alcohol, and placebo are used to test/validate the approach. Results The sleep deprivation model detected abnormal driving behavior in the simulator with an accuracy of 77 ± 9%. Abnormal driving behavior after alprazolam, and to a lesser extent also after alcohol intake, showed remarkably similar characteristics to sleep deprivation. The average probability score for alprazolam and alcohol measurements was 0.79, for alcohol 0.63, and for placebo only 0.27 and 0.30, matching the expected relative drowsiness. Conclusion We developed a model detecting abnormal driving induced by sleep deprivation. The model shows the similarities in driving characteristics between sleep deprivation and other interventions, i.e., alcohol and alprazolam. Consequently, our model for sleep deprivation may serve as a next reference point for a driving test battery of newly developed drugs.
|
2022-09-21T16:52:28.354Z
|
43,414,311 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/68.384528",
"MAG": "2161044879",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We propose and demonstrate a liquid-crystal and grating based optical cross-connect add-drop switch that operates simultaneously on several wavelengths channels. We demonstrate an 8 channels switch with 4 nm channel spacing, a flat-top frequency response and 30 dB extinction ratio.<<ETX>>
|
2022-12-10T01:19:35.861Z
|
222,318,744 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/10408363.2020.1828811",
"MAG": "3091885289",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Abstract Machine learning (ML) is gaining increased interest in clinical laboratory medicine, mainly triggered by the decreased cost of generating and storing data using laboratory automation and computational power, and the widespread accessibility of open source tools. Nevertheless, only a handful of ML-based products are currently commercially available for routine clinical laboratory practice. In this review, we start with an introduction to ML by providing an overview of the ML landscape, its general workflow, and the most commonly used algorithms for clinical laboratory applications. Furthermore, we aim to illustrate recent evolutions (2018 to mid-2020) of the techniques used in the clinical laboratory setting and discuss the associated challenges and opportunities. In the field of clinical chemistry, the reviewed applications of ML algorithms include quality review of lab results, automated urine sediment analysis, disease or outcome prediction from routine laboratory parameters, and interpretation of complex biochemical data. In the hematology subdiscipline, we discuss the concepts of automated blood film reporting and malaria diagnosis. At last, we handle a broad range of clinical microbiology applications, such as the reduction of diagnostic workload by laboratory automation, the detection and identification of clinically relevant microorganisms, and the detection of antimicrobial resistance.
|
2023-01-01T17:14:59.722Z
|
54,937,788 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4236/JCPT.2011.13007",
"MAG": "2015762681",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Synthesis of the title compound was carried out by base-catalyzed cyclization of 1-pivaloyl-3-(2-chloro-4-nitrophenyl) thiourea with α-bromoacetone produced in situ. The structure was confirmed by the spectroscopic and elemental analysis and single crystal X-ray diffraction data. It crystallizes in the triclinic space group P-1 with unit cell dime sions a = 8.7137(10), b = 10.2010(14), c = 10.6593(13), α = 62.671(9), β = 82.701(10), γ = 79.762(10), V = 827.21(8) A³, Z = 2.
|
2022-06-04T14:34:07.296Z
|
208,690,295 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5958/0974-360X.2019.00645.0",
"MAG": "2979611766",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Solubility is a key parameter for oral bioavailability of poorly water soluble drugs. Ramipril is sparingly soluble in water which affects the absorption of drug via GIT, and ultimately makes the drug with low bioavailability. In the present study is solubility enhancement of Ramipril by solid dispersion technique. Solid dispersion of Ramipril is prepared by using two polymers ie: Polyvinyl Pyrrolidone (PVP K30) and Polyethylene Glycol 4000 (PEG 4000) in different ratios (1:1, 1:2, 1:3) using solvent evaporation method. On the basis of % drug content and solubility study S.D.2 and S.D.5 solid dispersion were selected an taken for formulation of fast dissolving tablet of Ramipril. On evaluating various FDTs of Ramipril the best formulation was found to be F6 (1:2 PEG 4000) showed disintegration time was 28 sec. and cumulative percentage drug release 97.68 % in 40 min.
|
2022-01-27T08:43:20.338Z
|
55,424,061 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5539/IJPS.V9N4P1",
"MAG": "2754355377",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Psychopathy is one of the most puzzling clinical diagnosis and has been a subject to numerous theoretical attempts to define this personality disorder. Although not being recognised as an independent disorder in the DSM-5, the disorder is manifested in different areas of the individual’s personality and subsequently became subject of consideration as syndromal, not a simple disorder. This condition is usually stable and long-lasting, its onset usually traced back to childhood or adolescence, often being undiagnosed and/or successfully masked by the psychopath. Some psychopaths are quite successful in their profession, others are commonly related to the violence or crime.
|
2022-09-11T12:08:21.008Z
|
250,656,257 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/03611981221107010",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Dockless e-scooters were used for 86 million trips in the United States in 2019, indicating great potential as a new transportation mode in U.S. cities and on university campuses. Yet, little is known about how e-scooter users interact with people walking, bicycling, and driving. Although several studies have examined e-scooter injuries reported in hospital data, transportation-related near misses are chronically understudied in general, and even more so for this newer mode of transportation. In this paper we present the results of an online survey of 1,256 university staff (22% response rate) in Tempe, AZ. Using a single population, we compared the prevalence of self-reported incidents and injuries among those who use e-scooters, walk, and bicycle. Our results indicated a higher percentage of respondents reported incidents associated with walking (25%) than e-scooting (11%) or bicycling (9%), but e-scooter users were the most likely to report incidents resulting in a crash. E-scooter users were also more likely to report issues related to pavement, equipment, or losing control, whereas people walking and bicycling were more likely to report conflicts with other roadway users. Our findings suggest important areas for policy and infrastructure innovation, including prioritizing separate space for e-scooters to mitigate conflicts with pedestrians, and continuing to evolve rider training and speed governance to help keep e-scooter users safe. Other findings underscore the importance of measuring near misses to develop a comprehensive picture of transportation safety.
|
2022-10-24T15:34:55.136Z
|
252,288,022 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.52748/lurralde.2016.39.36",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
El presente artículo trata de analizar la visión de los universitarios después de cuatro años del nacimiento del movimiento 15M. Este fue un movimiento surgido en España en el año 2011 reclamando cambios sociales y políticos. Su nacimiento no siguió el proceso de los movimientos del pasado, y nació y se desarrolló de manera muy diferente. El presente texto comienza dando una panorámica histórica de los movimientos sociales hasta llegar a los orígenes y desarrollo de dicho movimiento, y su repercusión a escala mundial. Para finalmente, estudiar las percepciones de los universitarios sobre el movimiento en el momento actual.
|
2022-09-16T15:56:01.552Z
|
207,059,718 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1210/en.2008-1772",
"MAG": "2075522667",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://academic.oup.com/endo/article-pdf/150/7/3101/23242654/endo3101.pdf"
}
|
Neuromedin U (NMU) and neuromedin S (NMS) are structurally related neuropeptides that have been reported to modulate energy homeostasis. Pharmacological data have shown that NMU and NMS inhibit food intake when administered centrally and that NMU increases energy expenditure. Additionally, NMU-deficient mice develop obesity, whereas transgenic mice overexpressing NMU are lean and hypophagic. Two high-affinity NMU/NMS receptors, NMUR1 and NMUR2, have been identified. NMUR1 is predominantly expressed in the periphery, whereas NMUR2 is predominantly expressed in the brain, suggesting that the effects of centrally administered NMU and NMS are mediated by NMUR2. To evaluate the role of NMUR2 in the regulation of energy homeostasis, we characterized NMUR2-deficient (Nmur2(-/-)) mice. Nmur2(-/-) mice exhibited a modest resistance to diet-induced obesity that was at least in part due to reduced food intake. Acute central administration of NMU and NMS reduced food intake in wild-type but not in Nmur2(-/-) mice. The effects on activity and core temperature induced by centrally administered NMU were also absent in Nmur2(-/-) mice. Moreover, chronic central administration of NMU and NMS evoked significant reductions in body weight and sustained reductions in food intake in mice. In contrast, Nmur2(-/-) mice were largely resistant to these effects. Collectively, these data demonstrate that the anorectic and weight-reducing actions of centrally administered NMU and NMS are mediated predominantly by NMUR2, suggesting that NMUR2-selective agonists may be useful for the treatment of obesity.
|
2022-11-11T15:03:05.450Z
|
115,513,007 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1061/(ASCE)WR.1943-5452.0000880",
"MAG": "2800786091",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
AbstractThe first step in effective design of contaminated aquifer site remediation is the accurate characterization of contaminant sources, which requires a large amount of concentration measureme...
|
2022-11-17T16:04:58.211Z
|
57,871,710 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1161/str.46.suppl_1.wp132",
"MAG": "2261554727",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Background and Purpose:
Poststroke depression (PSD) is an important complication of stroke. We studied long-term PSD after intracerebral hemorrhage (ICH) at young age, as well as the quality of life of the survivors.
Methods:
We gathered clinical and imaging data on young ICH patients between age 16 and 49 treated in the Helsinki University Central Hospital between January 2000 and March 2010. The survivors were interviewed with structural questionnaires including Beck Depression Inventory II (BDI-II), Hospital Anxiety and Depression Scale (HADS), EuroQol (EQ-5D), Pain Anxiety Symptoms Scale (PASS-20), Brief Pain Inventory (BPI), and Montreal Congnitive Assessment (MOCA). Univariate analysis was performed to identify baseline factors associated with PSD (BDI-II score > 13). Correlation between degree of disability measured by modified Rankin Scale score and PSD was analyzed.
Results:
Median follow-up time was 9.7 [7.0-12.0] years. PSD was present among 30 (23.1%) out of 130 patients included. Mild or moderate emotional distress was present in 47 (36.2%) patients (HADS score > 7). Discomfort or pain was reported by 55 (42.3%) patients (measured by EQ-5D). Higher degree of disability was associated with symptoms of depression (higher BDI-II scores, p=0.001), and emotional distress (higher HADS scores, p=0.004). The only baseline factor identified to associate with PSD was hydrocephalus (p=0.014). Median PASS-20 score was 9 (IQR 0-25), median BPI score was 5 (0-23), and median MOCA score was 26 (22-28).
Conclusions:
One out of four survivors of ICH at young age suffers long-term PSD. Higher degree of disability predicted occurrence of PSD.
|
2022-03-22T15:45:04.744Z
|
121,959,491 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1071/ph740673",
"MAG": "2038596968",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "http://www.publish.csiro.au/ph/pdf/ph740673"
}
|
Some recent theories of disordered alloys are discussed with particular emphasis on their application to short-range ordered alloys. Comparisons are made in the case when only two-atom correlations are present. The probability variation method of Clapp (1969, 1971) is applied to allow inclusion of n-atom correlations which are dependent on the experimentally observable two-atom correlations. It is suggested that the cell method of Tsukada (1969) may be extended in the same manner.
|
2022-09-07T02:55:18.390Z
|
154,405,011 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/088636877901100208",
"MAG": "2101843822",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
overseas, namely, the concept of compulsory employer-sponsored pension plans. This approach attempts to provide income security for the individual through a combination of Social Security and legally mandated employer-sponsored pension plans, rather than through a continued expansion of the former. Considering the frustrations authorities in the developed countries of Western Europe and North America are experiencing in establishing their present Social Securi-
|
2022-02-09T01:51:24.506Z
|
122,016,590 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1142/S0218348X96000327",
"MAG": "2151685848",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The concept of fractal form analysis is introduced, in which fractal metrication is defined for partial objects of fractals as a cmD or b mD with the fractal dimensionality D.
|
2022-02-09T19:34:11.606Z
|
3,273,658 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1159/000205162",
"MAG": "2128434802",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A simple needle aspiration of marrow from the sternum was performed in a middle-aged woman with severe protein-calorie malnutrition and osteoporosis. Though carefully performed, a separation of the sternal-manubrial junction occurred with pain but no other serious sequelae. The subject of complications from marrow aspiration for diagnostic and therapeutic purposes is discussed.
|
2022-06-26T02:21:41.794Z
|
71,571,332 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/03670244.1993.9991344",
"MAG": "1991603657",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In 1982, WHO estimated that 20 million infants had low birthweights (LBW) (i.e., <2500 g or 5.5 lb). Most were born in developing countries. Yet for Africa, few studies have examined the relationship between maternal nutrition and birth outcomes. Over 540 hospital records were examined to 1) estimate the proportion of LBW infants. Between 23 and 80 women were studied prospectively to: 2) examine the effects of maternal health complaints on pregnancy outcomes, 3) examine the relationship between weight gain during the 3rd trimester and pregnancy outcome, and 4) determine a weight gain associated with a favorable birthweight range for this sample of women. Results show a positive relationship between birthweight and 6th month maternal Hb values. A 3rd trimester gain of 6.62 kg (14.6 lb) is correlated with a favorable pregnancy outcome. Education was positively associated with 6th month pregnancy weights. Public health workers should concentrate both on iron deficiency anemia and weight gain during the last ...
|
2022-03-05T22:22:58.304Z
|
209,517,988 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/acsami.9b11995",
"MAG": "2998106870",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The urgency of high performance solid electrolytes has aroused considerable focus on NASICON ceramics. Optimization of processing routes to dense, defect free materials has yet to receive sufficient attention to date. Although traditional solid state reaction methods followed by repetitive ball milling and sintering up to 10 h above 1200°C are common place, the resulting average particle sizes (APSs) are usually too large to produce dense, robust structures because of excessive grain growth. In this study, nanopowders (NPs) are produced that offer a superior opportunity to make dense, high phase purity sintered bodies. Here we report on the effect of sintering conditions on the microstructures and phase of Ce4+-substituted NASICON samples, Na3CexZr2-xSi2PO12 (x=0, 0.1, 0.2, 0.3). NPs permit processing fine-grained solid-state electrolytes with 98% relative density at 1100°C/5 h. In addition, Rietveld refinement was applied to evaluate 3-D Na-ion diffusion channels among different NASICON samples. Also, it is found that adding 5 at% Ce4+ does not change the phase structure but dramatically enlarges the Na+ diffusion "bottleneck" from 5.4 to 5.6 Å2. This may be one reason these samples to exhibit conductivities of 2.4×10-2 S cm-1 at 140°C.
|
2022-12-12T16:54:53.637Z
|
52,923,792 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1097/QAD.0000000000002036",
"MAG": "2895361428",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Objective: The aim of this study was to systematically review the literature on gendered implications of incarceration for HIV outcomes and engagement in care for women living with HIV (WLWH). Design: We systematically searched seven bibliographic databases, for peer-reviewed English-language studies, published between 2007 and 2017 reporting on incarceration, women (transgender inclusive) and HIV. Methods: Articles were included for evaluation if they reported outcomes for at least one of three measures of interest: viral load, antiretroviral therapy (ART) adherence or engagement in care among WLWH along incarceration trajectories. Results: Out of 1119 studies, 24 (2%) met the inclusion criteria. Of these 24 studies, the majority (n = 23) were conducted in the USA, 19 included samples of women and men and seven studies were transgender inclusive. Our review did not reveal clear sex differences in HIV outcomes during periods of incarceration; however, studies reporting postincarceration outcomes demonstrated significant sex disparities in all three outcomes of interest. Following incarceration, women were less likely to be virally suppressed, less likely to achieve optimal ART adherence and less likely to be engaged in care. Conclusion: Despite growing numbers of incarcerated WLWH globally, there is a substantial gap in research examining the impact of incarceration on HIV outcomes for WLWH. Significant sex disparities in HIV outcomes and engagement in care exist along incarceration trajectories for WLWH, especially postincarceration. For improved health outcomes, research is needed to examine the experiences of WLWH throughout incarceration trajectories to develop interventions tailored to the specific needs of WLWH both during and following incarceration.
|
2022-12-19T11:27:20.860Z
|
85,443,403 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4314/AJB.V7I10.58738",
"MAG": "2129812731",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Thermostable Newcastle disease (ND) vaccine virus strain I2 was investigated for its efficacy as foodborne vaccine, using maize offal as the vehicle. Immune response to vaccination and resistance to challenge were assessed by standard methods. Results showed that following primary vaccination, 40 (64.5%) out of the 62 birds produced detectable haemagglutination inhibiting (HI) antibody, but only 4 (6.5%) produced HI (log2) antibody titre 3.0 regarded as protective with a geometric mean titre (GMT) of 3.1. After a booster dose, 49 (79.0%) seroconverted and 20 (32.3%) had HI (log2) titres 3.0 with GMT of 4.9. When challenged all vaccinated birds survived while all control (unvaccinated) birds died. Prechallenge HI antibody titre of 50 vaccinated birds selected for challenge showed that 13 (26.0%) had titres 3.0 and GMT = 4.5, while post-challenge, 31 (62.0%) had HI (log2) 3.0 with GMT of 7.2. Using Student t test analysis of significance, the birds were observed to show 70% HI antibody production at a P 0.3 and 3 degree of freedom (df), and 70% secondary immune response on challenge at 4df. It is therefore concluded that the vaccine could be effective for protection of village chickens as food-borne vaccine provided the carrier foods are adequately treated.
|
2022-12-20T06:16:23.030Z
|
145,194,223 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1098/rsnr.2008.0035",
"MAG": "2128747542",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "http://rsnr.royalsocietypublishing.org/content/63/2/169.full.pdf"
}
|
The early development and blossoming of electron microscopy in the twentieth century are outlined with particular reference to biological applications, and the establishment and demise of facilities for the Faculty of Science in a London college are charted in relation to funding, staffing, and economic pressures. Use of these facilities for research, teaching and the promotion of science declined as the pressure to maximize outside income increased.
|
2022-02-09T06:36:11.465Z
|
141,785,846 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/13518046.2015.1061827",
"MAG": "1502164574",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The officer corps of the Manchukuo Army was formed on a multinational basis in accordance with the fundamental state principle of the “common home” for the five Nations of Manchukuo. The formation of the Russian officer corps in the Manchukuo Army started with the organization of the Asano detachment in 1938. The Japanese commanders relied on émigré youth, not the Russian Imperial Army’s officers. The nucleus of the Russian officer corps was émigré activists of anti-Bolshevik organizations who considered the Asano detachment the basis of a “White Army.” However, the leadership of émigré units was in the hands of the Japanese secret services, and the training of Russian regulars was based on the ideas of Bushido. Despite all efforts of the Japanese commanders, Russian officers did not meet their expectations in the fight against the Soviet Army in August 1945.
|
2022-02-09T08:21:56.028Z
|
191,951,817 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5167/UZH-90873",
"MAG": "2776401343",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Im Trichtermodell werden Gesprachsfuhrungstechniken in der Einvernahme erkenntnispsychologisch gegliedert. Offene Techniken dienen dem freien Bericht. Spater verengt sich die Technik auf W-Fragen. Vorgehalten sollen zuerst innere Widerspruche, danach sollen Fragen im Zusammenhang mit vorhandenen Beweismitteln gestellt werden. Erst zuletzt sollen die ermittelten Beweiselemente tatsachlich offengelegt werden. Der Tatvorwurf muss auf den Punkt gebracht werden. Nach jedem Zugestandnis wird der Trichter der Befragungstechniken beginnend mit dem freien Bericht erneut durchlaufen.
|
2022-08-05T20:52:47.286Z
|
158,011,462 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.24297/IJMIT.V10I2.641",
"MAG": "2581919171",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Actually this is the problem of most of the countries to move or strengthen their economy by maintaining all necessary requirements in this light we worked out for the identification of the variables/reasons which can create the ways for more money available in the economy for utilizing it for growth and development, for that reason data was collected from the secondary sources like ministry of finance, state bank of Pakistan and applied linear regression to check the relationship, and concluded that model of the equation if perfect which clearly identifies that tax collections are highly and positively correlated with the monetary assets available in the country means when tax collection base is exactly planned or implemented no doubt collection will improve and this improvement will lead to more money available in the economy for the all reasons which leads the economic system towards growth and development.
|
2022-08-26T13:57:24.178Z
|
72,159,535 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/J.1360-0443.1972.TB01191.X",
"MAG": "2049371529",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Summary
The following paper gives cm account of the prevalence of alcoholism within American industry. It examines the correlation between alcoholism and certain types of work, job classification and jot stresses. After outlining the way this problem is at present being approached in the United States, a farther programme of action for operation within industry itself is discussed.
|
2022-09-11T04:55:31.290Z
|
250,151,231 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2991/assehr.k.220602.032",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBYNC",
"status": "GOLD",
"url": "https://www.atlantis-press.com/article/125975286.pdf"
}
|
Malnutrition has always been a concern in the world, including Indonesia. Malnutrition is an individual nutritional problem that can be observed both externally and internally based on the nutritional intake consumed. Balanced nutrition is the key to optimal growth and development. Excess or lack of nutrition has a negative impact on survival, especially for children. In the first days children must get good and balanced nutrition in order to have a strong immune system so that it is difficult to be exposed to disease and grow and develop optimally. The writing of this article uses a literature review research method, which aims to identify and describe the causes of malnutrition based on research results that have been proven to be true. Global nutrition problems have an impact on the layers of society who are in small groups, including households. Parents find it difficult to access education, employment and food availability, thus affecting family conditions, including children's health. Children do not get a balanced nutritional intake so that it inhibits growth and development and lowers the body's immunity. Finally, children are easily and quickly infected with diseases and invite various nutritional problems.
|
2022-09-23T00:43:36.301Z
|
111,528,260 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1142/9789814324052_0050",
"MAG": "2314324723",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper deals with the optimization of process parameters in high strength sheet metal forming in order to reduce the springback effects after forming. The optimum parameters including holder force, friction coefficient and die radius which influence springback are studied through numerical simulation and orthogonal experiment. For predicting the springback accurately, the uniform experiment was used and BP neural network model was built up. The results show that springback of the front side rail is seriously influenced by these parameters, and the springback under the case of giving a group of process parameters can be predicted by the BP neural network model.
|
2022-02-10T04:06:14.867Z
|
12,253,250 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/1077801214551289",
"MAG": "2150382948",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This school-based sample provides the largest estimate of physical and psychological dating violence (DV) victimization and the only report of DV perpetration among high school students. Among 14,190 students in relationships, 33.4% disclosed DV by a partner (victimization) and 20.2% used these same behaviors against a partner (perpetration) in the past 12 months. Physical DV victimization (13%) was less frequently disclosed than psychological DV (23%). Rates of DV victimization and perpetration were highest among females, those receiving free or reduced-price meals, those not exclusively attracted to the opposite sex, students reporting parental or guardian partner violence, binge drinking, and bullying.
|
2022-12-14T22:27:14.596Z
|
54,072,754 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5267/J.MSL.2013.06.010",
"MAG": "2165866655",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Article history: Received January 12, 2013 Received in revised format 30 May 2013 Accepted 5 June 2013 Available online June 8 2013 This paper presents an empirical investigation to find out important factors influencing exchange authorities for keeping firms on Tehran Stock Exchange. The proposed study uses logistic regression technique to study the effects of five factors including liquidity, solvability, profitability, cash flow and size of auditing firm. The results of the study show that only solvability is the most important factor according to auditing officials for extending listed firms on this exchange while the effects of other factors, liquidity, capability of meeting commitments, profitability, cash flow and size of auditing firm, are not statistically significance. © 2013 Growing Science Ltd. All rights reserved.
|
2022-01-27T11:18:42.998Z
|
113,297,803 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3141/2527-09",
"MAG": "2256959911",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
FHWA and other public agencies encourage monitoring of nonmotorized traffic volumes and are collaborating with researchers in projects to test monitoring technologies and develop nonmotorized monitoring programs. This paper reports findings from research in Minnesota to validate the use of commercially available pneumatic tube counters to count bicycles in mixed traffic flows on urban roadways. Pneumatic tube counters and video cameras were installed in different configurations at two locations on arterial roadways with different traffic volumes. Bicycle counts from the tube counters were compared with manual counts from video to determine both percentage error and absolute error rates. Researchers matched time stamps from the counters and video and inspected discrepancies to determine causes of error. Calibration equations to adjust for systematic counter error were estimated by regressing hourly manual counts on hourly automated counts. The tube counters generally under-counted bicycles: error rates for the observation periods ranged from 6% to 57% depending on the location, configuration of deployment, type of device, and classification algorithm. Absolute error rates were substantially higher. Inspection of video indicated most false negatives (i.e., undercounts) were caused by occlusion. Calibration equations generally had moderate to very good fit (R2 values from .82 to .92). Agencies can adapt standard, commercially available pneumatic tube counters to collect bicycle counts in mixed traffic flows; but depending on the site, traffic volumes, configuration, and deployment, error rates may be high. The practicability of using tube counters to count bicycles in mixed traffic flows depends on the applications and the relative need for accuracy in measurement.
|
2022-09-02T12:48:24.822Z
|
226,323,168 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.14198/ingeo2020.covf",
"MAG": "3094340156",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.investigacionesgeograficas.com/article/view/2020-criterios-a-utilizar-para-la-determinacion-de-delimitaciones-submunicipales/pdf"
}
|
Settlement is one of the most incontestable geographical realities and has a clear impact on the basic territorial organisation of the state – as well as a long research tradition. However, on many occasions, its elementary cells – municipalities in the Spanish case – include an internal diversity of situations that should be thoroughly understood. The objective of this study is to establish a common protocol in Andalusia for the delimitation of municipal districts in subunits (as proposed by regional regulations). Sources of information that incorporate sub-municipal boundaries are analysed to establish a delimiting methodology based on differentiated criteria (territorial, historical, administrative, and zonal design) with the support of cartographic examples drawn at regional and municipal scales. The results speak of the diversity of possibilities that are found today in Andalusia, although they are not applicable in all cases. In the discussion, the advantages presented by this procedure are reviewed, as well as their potential for better organisation and management of territorial resources. The conclusions synthesise the main aspects addressed and open new lines of research and action for the future.
|
2022-09-02T03:55:42.896Z
|
129,388,550 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1029/JB074I008P02099",
"MAG": "2061706425",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Simple two- and three-dimensional networks of electrical resistors, from which elements are eliminated in a random fashion, have electrical characteristics like those of brine-saturated rocks. The porosity-resistivity relation commonly observed for rocks and known as Archie's law was followed by these networks more or less independently of details of network geometry. Study of the networks suggests that under hydrostatic pressure crack population as well as crack size changes in typical rocks; some cracks must become almost nonconducting in rocks under pressure.
|
2022-09-15T02:36:01.640Z
|
118,381,528 |
{
"externalids": {
"ACL": null,
"ArXiv": "1104.5191",
"DOI": "10.1017/S1743921311017443",
"MAG": "2984504258",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract Asteroseismic investigations, particularly based on data on stellar oscillations from the CoRoT and Kepler space missions, are providing unique possibilities for investigating the properties of stellar interiors. This constitutes entirely new ways to study the effects of dynamic phenomena on stellar structure and evolution. Important examples are the extent of convection zones and the associated mixing and the direct and indirect effects of stellar rotation. In addition, the stellar oscillations themselves show very interesting dynamic behaviour. Here we discuss examples of the results obtained from such investigations, across the Hertzsprung-Russell diagram.
|
2022-10-25T07:43:35.338Z
|
253,056,384 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/ani12202834",
"MAG": null,
"PubMedCentral": "9597706"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2076-2615/12/20/2834/pdf?version=1666170986"
}
|
Simple Summary The genome of domestic sheep (Ovis aries) harbors at least twenty-seven copies of enJSRVs, endogenous retroviruses (ERVs) highly related to the exogenous and pathogenic Jaagsiekte sheep betaretrovirus (JSRV). Interestingly, some of these loci are insertionally polymorphic, that is they are present only in some individuals or populations of their host species. This differential distribution of enJSRVs has provided important insights into tracing host and viral evolution. In this study, we report the first comparative fluorescent in situ hybridization (FISH) mapping of genetically characterized enJSRVs in domestic sheep (2n = 54) and river buffalo (Bubalus bubalis, 2n = 50), and reveal a high conservation of enJSRVs chromosome localization between these two species. Abstract Endogenous retroviruses (ERVs) are the remnants of ancient infections of host germline cells, thus representing key tools to study host and viral evolution. Homologous ERV sequences often map at the same genomic locus of different species, indicating that retroviral integration occurred in the genomes of the common ancestors of those species. The genome of domestic sheep (Ovis aries) harbors at least twenty-seven copies of ERVs related to the exogenous and pathogenic Jaagsiekte sheep retrovirus (JSRVs), thus referred to as enJSRVs. Some of these loci are unequally distributed between breeds and individuals of the host species due to polymorphic insertions, thereby representing invaluable tools to trace the evolutionary dynamics of virus populations within their hosts. In this study, we extend the cytogenetic physical maps of sheep and river buffalo by performing fluorescent in situ hybridization (FISH) mapping of twenty-three genetically characterized enJSRVs. Additionally, we report the first comparative FISH mapping of enJSRVs in domestic sheep (2n = 54) and river buffalo (Bubalus bubalis, 2n = 50). Finally, we demonstrate that enJSRV loci are conserved in the homologous chromosomes and chromosome bands of both species. Altogether, our results support the hypothesis that enJSRVs were present in the genomes of both species before they differentiated within the Bovidae family.
|
2022-11-04T00:25:43.611Z
|
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