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|---|---|---|---|
learning to walk is a complex , gradual process of maturation of motivation , the integration of subcortical pattern-generating centers with the neural substrate for control of posture and balance , and important changes in body proportions and bone and muscle strength .
|
process_includes_biological_process
|
{
"id": "C0023185",
"name": "learning",
"pos": [
0,
8
]
}
|
{
"id": "C0026605",
"name": "motivation",
"pos": [
65,
75
]
}
|
the effect of histamine-induced suppressor factor ( hsf ) on the humoral immune response was examined with the model of polyclonal b cell activation induced during a primary mixed lymphocyte culture ( mlc ) .
|
process_includes_biological_process
|
{
"id": "C0020967",
"name": "humoral immune",
"pos": [
65,
79
]
}
|
{
"id": "C1155003",
"name": "b cell activation",
"pos": [
131,
148
]
}
|
the relative proportion of the three peaks changed as a function of embryonic age and maturation : more of the alpha 1 ( i ) chains with the highest hydroxylysine content was present in the collagen synthesized earliest during embryonic development .
|
process_includes_biological_process
|
{
"id": "C0678723",
"name": "maturation",
"pos": [
86,
96
]
}
|
{
"id": "C0013936",
"name": "embryonic development",
"pos": [
227,
248
]
}
|
thus , our data indicate that the expression of these two genes are primarily regulated at the transcriptional level .
|
process_includes_biological_process
|
{
"id": "C0017262",
"name": "expression",
"pos": [
34,
44
]
}
|
{
"id": "C0040649",
"name": "transcriptional",
"pos": [
95,
110
]
}
|
through the use of this assay with deletion mutations of a drosophila trnaarg gene , we demonstrate that stable transcription complex formation is dependent on the dna region extending from the 5 ' end of the sequence encoding the t-stem of the trna to more than 10 base pairs downstream from the transcription termination sequence .
|
process_includes_biological_process
|
{
"id": "C0040649",
"name": "transcription",
"pos": [
112,
125
]
}
|
{
"id": "C0597600",
"name": "transcription termination",
"pos": [
297,
322
]
}
|
nutrition and immunity : the influence of diet on autoimmunity and the role of zinc in the immune response .
|
process_includes_biological_process
|
{
"id": "C0020964",
"name": "immunity",
"pos": [
14,
22
]
}
|
{
"id": "C0301872",
"name": "immune response",
"pos": [
91,
106
]
}
|
[ histogenesis of the heart conduction system in human embryos and fetuses . the differentiation of the atrioventricular ( his ) bundle ] .
|
process_includes_biological_process
|
{
"id": "C0178679",
"name": "histogenesis",
"pos": [
2,
14
]
}
|
{
"id": "C0007589",
"name": "differentiation",
"pos": [
81,
96
]
}
|
there were no significant differences in overall reproductive efficiency ( pregnancy and foaling rates ) among the three farms and the incidence of observed twin abortions or births was low on all three farms ( 0.4 , 0.2 , and 0 % , respectively ) .
|
process_includes_biological_process
|
{
"id": "C0035150",
"name": "reproductive",
"pos": [
49,
61
]
}
|
{
"id": "C0032961",
"name": "pregnancy",
"pos": [
75,
84
]
}
|
such behaviour parallels that known for many crown and non-cyclic polyethers and is therefore identified with the polyether portions of the polymer , which are thought to adopt helical conformations surrounding the complexed cations .
|
process_includes_biological_process
|
{
"id": "C0004927",
"name": "behaviour",
"pos": [
5,
14
]
}
|
{
"id": "C0039869",
"name": "thought",
"pos": [
160,
167
]
}
|
the data presented indicate that convergent transcription interferes with copa expression by abolishing or reducing normal copa transcription termination .
|
process_includes_biological_process
|
{
"id": "C0040649",
"name": "transcription",
"pos": [
44,
57
]
}
|
{
"id": "C0597600",
"name": "transcription termination",
"pos": [
128,
153
]
}
|
yeast mutants with ribosomal subunits resistant to the translational effects of one of these antibiotics are specifically resistant to curing by that antibiotic , indicating that these substances act on the virus by their effect on protein synthesis .
|
process_includes_biological_process
|
{
"id": "C1519614",
"name": "translational",
"pos": [
55,
68
]
}
|
{
"id": "C0597295",
"name": "protein synthesis",
"pos": [
232,
249
]
}
|
these results suggest that 1 alpha,25 ( oh ) 2d3 inhibits proliferation of wehi-3 cells by blocking transition of the cells from the g0-g1 to the s phase , resulting in induction of the g0-g1-arrested cells to differentiate into macrophages .
|
process_includes_biological_process
|
{
"id": "C0079395",
"name": "g1",
"pos": [
136,
138
]
}
|
{
"id": "C1517342",
"name": "g1-arrested",
"pos": [
189,
200
]
}
|
since the control of eukaryotic gene expression is known to involve numerous sequence elements , some acting at a distance from the site of transcription ( dynan and tjian , 1985 ) , genetic perturbations within the cell ( e.g . a reciprocal translocation ) could be expected to deregulate certain genes , leading to their under- or overexpression analogous to activation of the c-myc oncogene by the 8 ; 14 translocation in burkitt 's lymphoma .
|
process_includes_biological_process
|
{
"id": "C0017262",
"name": "gene expression",
"pos": [
32,
47
]
}
|
{
"id": "C0040649",
"name": "transcription",
"pos": [
140,
153
]
}
|
since the control of eukaryotic gene expression is known to involve numerous sequence elements , some acting at a distance from the site of transcription ( dynan and tjian , 1985 ) , genetic perturbations within the cell ( e.g . a reciprocal translocation ) could be expected to deregulate certain genes , leading to their under- or overexpression analogous to activation of the c-myc oncogene by the 8 ; 14 translocation in burkitt 's lymphoma .
|
process_includes_biological_process
|
{
"id": "C0017262",
"name": "gene expression",
"pos": [
32,
47
]
}
|
{
"id": "C1514559",
"name": "overexpression",
"pos": [
333,
347
]
}
|
reproductive effects of the environmental pollutant methylmercuric chloride administered as a single dose per os during pregnancy were studied both in treated mice ( g0 generation ) and in their prenatally exposed offspring ( g1 ) .
|
process_includes_biological_process
|
{
"id": "C0035150",
"name": "reproductive",
"pos": [
0,
12
]
}
|
{
"id": "C0032961",
"name": "pregnancy",
"pos": [
120,
129
]
}
|
expression of a wheat alpha-amylase gene in escherichia coli : recognition of the translational initiation site and the signal peptide .
|
process_includes_biological_process
|
{
"id": "C0017262",
"name": "expression",
"pos": [
0,
10
]
}
|
{
"id": "C1519613",
"name": "translational initiation",
"pos": [
82,
106
]
}
|
in order to evaluate the relative contribution of vagal and non-vagal afferences to increasing neural drive to the respiratory muscles in 14 asymptomatic asthmatic patients known to be responsive ( decrease in fev1 greater than 20 % of the control values ) to previous bronchial provocation test ( bpt ) with aerosolized histamine , we evaluated fev1 , breathing pattern and neuromuscular drive , as assessed by mouth occlusion pressure ( po.1 ) , under control conditions , during bpt with progressive doubling doses of inhaled histamine ( h ) and 5 min after inhalation of a bronchodilator agent ( reproterol ) ( b ) .
|
process_includes_biological_process
|
{
"id": "C0035203",
"name": "breathing",
"pos": [
353,
362
]
}
|
{
"id": "C0004048",
"name": "inhalation",
"pos": [
561,
571
]
}
|
while iron clearly appears to influence the production of exotoxin a at the transcriptional level , the molecular basis of this effect may involve several interacting factors affecting the initiation of transcription and perhaps mrna turnover .
|
process_includes_biological_process
|
{
"id": "C0040649",
"name": "transcriptional",
"pos": [
76,
91
]
}
|
{
"id": "C1158830",
"name": "initiation",
"pos": [
189,
199
]
}
|
the in vitro finding that expression of the albumin gene is strictly regulated by glucocorticoid was confirmed by an in vivo experiment in adrenalectomized rats showing that the transcription decreased markedly 14 days after adrenalectomy , but was restored rapidly by administration of hydrocortisone .
|
process_includes_biological_process
|
{
"id": "C0017262",
"name": "expression",
"pos": [
26,
36
]
}
|
{
"id": "C0040649",
"name": "transcription",
"pos": [
178,
191
]
}
|
in view of the biphasic immune response after antigen presentation , the purpose of this study was to determine the presence of ica and antibodies against the 64,000 islet antigen after separation of igm from igg to prevent interference between the two antibody classes .
|
process_includes_biological_process
|
{
"id": "C0301872",
"name": "immune",
"pos": [
24,
30
]
}
|
{
"id": "C0206431",
"name": "antigen presentation",
"pos": [
46,
66
]
}
|
since the immune response against m. leprae is entirely dependent on th cells , the hla class ii-linked ir gene products may well regulate the immune response by controlling the presentation of m. leprae antigens to th cells .
|
process_includes_biological_process
|
{
"id": "C0301872",
"name": "immune response",
"pos": [
10,
25
]
}
|
{
"id": "C0206431",
"name": "presentation",
"pos": [
178,
190
]
}
|
the partial expiratory flow volume curves in the infants with bpd were markedly concave , with tidal breathing approaching expiratory flow limitation .
|
process_includes_biological_process
|
{
"id": "C0035203",
"name": "breathing",
"pos": [
101,
110
]
}
|
{
"id": "C0231800",
"name": "expiratory",
"pos": [
123,
133
]
}
|
it seems likely that a specific mrna produced by t7 rna polymerase can rapidly saturate the translational machinery of e. coli , so that the rate of protein synthesis from such an mrna will depend primarily on the efficiency of its translation .
|
process_includes_biological_process
|
{
"id": "C1519614",
"name": "translational",
"pos": [
92,
105
]
}
|
{
"id": "C0597295",
"name": "protein synthesis",
"pos": [
149,
166
]
}
|
it was found that the parameter that can best characterize the respiratory function in the case of a positive intrapulmonary pressure is electrical activity of expiratory muscles .
|
process_includes_biological_process
|
{
"id": "C0035203",
"name": "respiratory function",
"pos": [
63,
83
]
}
|
{
"id": "C0231800",
"name": "expiratory",
"pos": [
160,
170
]
}
|
by the use of an artificial gene coding for rrna ( rdna gene ) , we found that transcription of the major precursor rrna in saccharomyces cerevisiae cells is stimulated 15-fold by a positive control element located 2 kilobases upstream of the transcription initiation site .
|
process_includes_biological_process
|
{
"id": "C0040649",
"name": "transcription",
"pos": [
79,
92
]
}
|
{
"id": "C1158830",
"name": "transcription initiation",
"pos": [
243,
267
]
}
|
the fact that the agp gene region mediating dexamethasone regulation was distinct from the transcribed region indicates that glucocorticoids increase agp gene expression primarily at the transcriptional rather than the posttranscriptional level .
|
process_includes_biological_process
|
{
"id": "C0017262",
"name": "gene expression",
"pos": [
154,
169
]
}
|
{
"id": "C0040649",
"name": "transcriptional",
"pos": [
223,
238
]
}
|
oncogene amplification during tumorigenesis of established rat fibroblasts reversibly transformed by activated human ras oncogenes .
|
process_includes_biological_process
|
{
"id": "C0007621",
"name": "tumorigenesis",
"pos": [
30,
43
]
}
|
{
"id": "C1510411",
"name": "transformed",
"pos": [
86,
97
]
}
|
after transfection into cv1 cells , the expression of a marker gene , ecogpt , was determined as a function of the position of that marker gene relative to the other transcription units and the position of the marker gene relative to enhancer elements on the plasmids .
|
process_includes_biological_process
|
{
"id": "C0017262",
"name": "expression",
"pos": [
40,
50
]
}
|
{
"id": "C0040649",
"name": "transcription",
"pos": [
166,
179
]
}
|
surprisingly , insertion of sv40 sequences within the first leader segment , at +33 relative to the start of transcription , significantly reduced the frequency of transcription initiation from the major late promoter .
|
process_includes_biological_process
|
{
"id": "C0040649",
"name": "transcription",
"pos": [
109,
122
]
}
|
{
"id": "C1158830",
"name": "transcription",
"pos": [
164,
177
]
}
|
regulated expression of a transfected mck gene containing the entire transcription unit with 3.3 kilobases of 5'-flanking sequence was also demonstrated during differentiation of the mm14 mouse myoblast cell line .
|
process_includes_biological_process
|
{
"id": "C0017262",
"name": "expression",
"pos": [
10,
20
]
}
|
{
"id": "C0040649",
"name": "transcription",
"pos": [
69,
82
]
}
|
because of the tremendous demand of reproduction on maternal calcium stores , the effects of egme on calcium and vitamin d metabolism during gestation were examined .
|
process_includes_biological_process
|
{
"id": "C0035150",
"name": "reproduction",
"pos": [
36,
48
]
}
|
{
"id": "C0032961",
"name": "gestation",
"pos": [
141,
150
]
}
|
the metapsychological view of freud as regards the repressed homicidal motivation in suicide is complemented by the views of garma and abadi .
|
process_includes_biological_process
|
{
"id": "C0035143",
"name": "repressed",
"pos": [
51,
60
]
}
|
{
"id": "C0026605",
"name": "motivation",
"pos": [
71,
81
]
}
|
to test the hypothesis that estrogen stimulates sexual behavior by inducing transcription of polyadenylated messenger rna , we studied the effects of cordycepin , an adenosine analog that disrupts polyadenylation , on the lordotic responses of ovariectomized female rats made sexually receptive with systemic injections of estradiol benzoate ( eb ) and progesterone ( p ) .
|
process_includes_biological_process
|
{
"id": "C0040649",
"name": "transcription",
"pos": [
76,
89
]
}
|
{
"id": "C0949765",
"name": "polyadenylation",
"pos": [
197,
212
]
}
|
analysis of transformed lines confirmed the beta-alpha read-through transcription , which was eliminated by the insertion of a different polyadenylation site within the coding region of the beta gene .
|
process_includes_biological_process
|
{
"id": "C0040649",
"name": "transcription",
"pos": [
68,
81
]
}
|
{
"id": "C0949765",
"name": "polyadenylation",
"pos": [
137,
152
]
}
|
the histogenesis of retinoblastoma , the most common intraocular tumor of childhood , has been recently attributed to a primitive retinal cell which is capable of differentiation into both neuronal and glial elements .
|
process_includes_biological_process
|
{
"id": "C0178679",
"name": "histogenesis",
"pos": [
4,
16
]
}
|
{
"id": "C0007589",
"name": "differentiation",
"pos": [
163,
178
]
}
|
because the 4.5s rna is stable , the decrease in transcription was assumed to be due to premature transcription-termination within the tpa gene .
|
process_includes_biological_process
|
{
"id": "C0040649",
"name": "transcription",
"pos": [
49,
62
]
}
|
{
"id": "C0597600",
"name": "transcription-termination",
"pos": [
98,
123
]
}
|
therefore , although no conclusions can be drawn about possible effects of am at the transcriptional level , it is concluded that am interferes with thyroid hormone responsive gene expression in rat liver at a post-transcriptional level .
|
process_includes_biological_process
|
{
"id": "C0017262",
"name": "gene expression",
"pos": [
176,
191
]
}
|
{
"id": "C0040649",
"name": "transcriptional",
"pos": [
215,
230
]
}
|
for the group of calves with colostrum immunity , after single hypodermic immunisation with doses from 10 ( 4 ) till 10 ( 5 ) cpe50/cm3 for adenovirus , was not proved immune response , as a result of blocking of the vaccinal antigen of colostrum antibodies .
|
process_includes_biological_process
|
{
"id": "C0020964",
"name": "immunity",
"pos": [
39,
47
]
}
|
{
"id": "C0301872",
"name": "immune response",
"pos": [
168,
183
]
}
|
some embryos were carefully inspected with a video recording system , every 1.44s and the cell divisions ( cytokinesis ) as well as formation of large , single blastomeres , each from two smaller ones , were recorded .
|
process_includes_biological_process
|
{
"id": "C0007590",
"name": "cell divisions",
"pos": [
90,
104
]
}
|
{
"id": "C0010813",
"name": "cytokinesis",
"pos": [
107,
118
]
}
|
the results of the mathematical analysis of the changes in the cast deviation angles of the is along the afferent and deferent tracts demonstrate their role in twisting and acceleration of the blood stream in the systolic phase and slowing down of the blood stream in the diastolic phase .
|
process_includes_biological_process
|
{
"id": "C0005775",
"name": "blood stream",
"pos": [
193,
205
]
}
|
{
"id": "C0012000",
"name": "diastolic",
"pos": [
272,
281
]
}
|
this work tests if such increased cell survival is associated with increased dna repair on uv damaged plasmid transformed into yeast .
|
process_includes_biological_process
|
{
"id": "C0007620",
"name": "cell survival",
"pos": [
34,
47
]
}
|
{
"id": "C0012899",
"name": "dna",
"pos": [
77,
80
]
}
|
some a/t combination sequences may serve as signals to the bacterial transcription machinery , in addition to the well-established ttgaca and tataat at positions -35 and -10 , respectively , and a run of ts at the transcription termination site .
|
process_includes_biological_process
|
{
"id": "C0040649",
"name": "transcription",
"pos": [
69,
82
]
}
|
{
"id": "C0597600",
"name": "transcription termination",
"pos": [
214,
239
]
}
|
[ immunity of viruses and the effectiveness of vaccines . mechanism of protective immune response of hosts to viruses ] .
|
process_includes_biological_process
|
{
"id": "C0020964",
"name": "immunity",
"pos": [
2,
10
]
}
|
{
"id": "C0301872",
"name": "immune response",
"pos": [
82,
97
]
}
|
in vitro transcription experiments show that initiation of transcription does not occur at the level of the putative 5s rrna gene promoter .
|
process_includes_biological_process
|
{
"id": "C0040649",
"name": "transcription",
"pos": [
9,
22
]
}
|
{
"id": "C1158830",
"name": "initiation",
"pos": [
45,
55
]
}
|
epidermal growth factor stimulates c-myc transcription in a way different from that of serum : ( 1 ) initiation of transcription is not significantly enhanced , but intragenic pausing is significantly abrogated ;
|
process_includes_biological_process
|
{
"id": "C0040649",
"name": "transcription",
"pos": [
41,
54
]
}
|
{
"id": "C1158830",
"name": "initiation",
"pos": [
101,
111
]
}
|
these results indicate that there are protein kinases which are restricted to the mitotic phase of the cell cycle and that they apparently partition between the cytoplasmic and chromosomal compartments of cells in mitosis .
|
process_includes_biological_process
|
{
"id": "C1155839",
"name": "mitotic",
"pos": [
82,
89
]
}
|
{
"id": "C0026255",
"name": "mitosis",
"pos": [
214,
221
]
}
|
a viral factor activated in the absence of virus transcription and not activated when rna synthesis occurs may be involved in the early mechanism of protein synthesis inhibition by vaccinia virus .
|
process_includes_biological_process
|
{
"id": "C0040649",
"name": "transcription",
"pos": [
49,
62
]
}
|
{
"id": "C1328948",
"name": "rna",
"pos": [
86,
89
]
}
|
the distribution and fate of laminin and type i and iv collagens could be correlated spatially and temporally with morphogenetic events during neural crest development .
|
process_includes_biological_process
|
{
"id": "C0026559",
"name": "morphogenetic",
"pos": [
115,
128
]
}
|
{
"id": "C0814002",
"name": "neural",
"pos": [
143,
149
]
}
|
the hypothesis is proposed that in these cases the chromosomal rearrangement is the primary event in tumorigenesis , leading to activation of a so far unknown oncogene located most likely at 8q12 .
|
process_includes_biological_process
|
{
"id": "C0007621",
"name": "tumorigenesis",
"pos": [
101,
114
]
}
|
{
"id": "C1518575",
"name": "activation",
"pos": [
128,
138
]
}
|
the e. coli rna polymerase holoenzyme initiates transcription from three promoter sites not efficiently utilized by the b. subtilis holoenzyme under optimal conditions for rna synthesis .
|
process_includes_biological_process
|
{
"id": "C0040649",
"name": "transcription",
"pos": [
48,
61
]
}
|
{
"id": "C1328948",
"name": "rna synthesis",
"pos": [
172,
185
]
}
|
immune responses of humans to a human diploid cell strain of rabies virus vaccine : lymphocyte transformation , production of virus-neutralizing antibody , and induction of interferon .
|
process_includes_biological_process
|
{
"id": "C0301872",
"name": "immune responses",
"pos": [
0,
16
]
}
|
{
"id": "C0024262",
"name": "lymphocyte transformation",
"pos": [
84,
109
]
}
|
in sharp contrast , mutants or defective vesicular stomatitis virions restricted in transcription were incapable of causing progressive inhibition of cellular rna synthesis even at massive multiplicities of infection .
|
process_includes_biological_process
|
{
"id": "C0040649",
"name": "transcription",
"pos": [
84,
97
]
}
|
{
"id": "C1514672",
"name": "of",
"pos": [
204,
206
]
}
|
the decrease in reproductive capacity of female offspring from mice treated with des during gestation was dose related ;
|
process_includes_biological_process
|
{
"id": "C0035150",
"name": "reproductive",
"pos": [
16,
28
]
}
|
{
"id": "C0032961",
"name": "gestation",
"pos": [
92,
101
]
}
|
the compared neoplasms were found to differ in the degree of cell proliferation disorders ( the mitotic activity , a preponderance of dividing cells at the stage of metaphase , the frequency of pathological mitoses and correlation of their different forms ) .
|
process_includes_biological_process
|
{
"id": "C0596290",
"name": "cell proliferation",
"pos": [
61,
79
]
}
|
{
"id": "C0025564",
"name": "metaphase",
"pos": [
165,
174
]
}
|
the compared neoplasms were found to differ in the degree of cell proliferation disorders ( the mitotic activity , a preponderance of dividing cells at the stage of metaphase , the frequency of pathological mitoses and correlation of their different forms ) .
|
process_includes_biological_process
|
{
"id": "C0596290",
"name": "cell proliferation",
"pos": [
61,
79
]
}
|
{
"id": "C0026255",
"name": "mitoses",
"pos": [
207,
214
]
}
|
two key components of neural development and regeneration , survival of the involved neurons and elongation of neuritic elements , are likely to depend on the availability of an appropriate trophic drive to these neurons .
|
process_includes_biological_process
|
{
"id": "C0814002",
"name": "neural development",
"pos": [
22,
40
]
}
|
{
"id": "C1514121",
"name": "survival",
"pos": [
60,
68
]
}
|
studies of the behavioral correlates of activity in reticular formation cells , usually performed in restrained animals , have found units whose discharge relates to sensory stimuli , pain and escape behavior , conditioning and habituation , arousal , complex motivational states , rem sleep , eye movements , respiration and locomotion .
|
process_includes_biological_process
|
{
"id": "C0004927",
"name": "behavior",
"pos": [
15,
23
]
}
|
{
"id": "C0026605",
"name": "motivational",
"pos": [
260,
272
]
}
|
the role of maturation and visual experience in the development of eye alignment in cats .
|
process_includes_biological_process
|
{
"id": "C0678723",
"name": "maturation",
"pos": [
12,
22
]
}
|
{
"id": "C1517080",
"name": "development",
"pos": [
52,
63
]
}
|
changes in the arterial or alveolar pco2 increased about 20 -- 30 mmhg following respiration arrest or 10 % co2 inhalation , and decreased about 20 mmhg following hyperventilation during 2 minutes , respectively .
|
process_includes_biological_process
|
{
"id": "C0035203",
"name": "respiration",
"pos": [
81,
92
]
}
|
{
"id": "C0004048",
"name": "inhalation",
"pos": [
112,
122
]
}
|
although classical canonical and noncanonical transcriptional start signals were detectable , polyadenylation signals were not observed .
|
process_includes_biological_process
|
{
"id": "C0040649",
"name": "transcriptional",
"pos": [
46,
61
]
}
|
{
"id": "C0949765",
"name": "polyadenylation",
"pos": [
94,
109
]
}
|
these may be represented by three different histogenetic lines : 1 ) spindle-shaped appendiceal cortical cells ( type 1-4 ) 2 ) medullary cells showing signs of squamous-epithelium differentiation ( type 5-6 ) 3 ) medullary cells with signs of glandular differentiation ( type 7-8 ) .
|
process_includes_biological_process
|
{
"id": "C0178679",
"name": "histogenetic",
"pos": [
44,
56
]
}
|
{
"id": "C0007589",
"name": "differentiation",
"pos": [
254,
269
]
}
|
the porch test involves inflation of a blood pressure cuff on the upper arm to a supra systolic ( +50 mmhg ) pressure for two minutes .
|
process_includes_biological_process
|
{
"id": "C0005775",
"name": "porch",
"pos": [
4,
9
]
}
|
{
"id": "C0039155",
"name": "systolic",
"pos": [
87,
95
]
}
|
the degree of maturation of each of the permanent teeth on the left side of the mandible was determined , and a dental maturation score was computed for each child .
|
process_includes_biological_process
|
{
"id": "C0678723",
"name": "maturation",
"pos": [
14,
24
]
}
|
{
"id": "C0028877",
"name": "dental",
"pos": [
112,
118
]
}
|
the relationship between the behavior of single-celled organisms and cognition in higher animals is explored .
|
process_includes_biological_process
|
{
"id": "C0004927",
"name": "behavior",
"pos": [
29,
37
]
}
|
{
"id": "C0009240",
"name": "cognition",
"pos": [
69,
78
]
}
|
nuclear run-on experiments show that ade1a , growth factors and ejras act on sml gene expression at the level of transcription .
|
process_includes_biological_process
|
{
"id": "C0017262",
"name": "gene expression",
"pos": [
81,
96
]
}
|
{
"id": "C0040649",
"name": "transcription",
"pos": [
113,
126
]
}
|
the observed stimulation can not be explained by an increased utilization of initiation complexes for multiple rounds of transcription as a similar level of stimulation by hmgs 1 and 2 was seen when rna synthesis was limited to one round per template dna by addition of a low level of sarkosyl after formation of initiation complexes .
|
process_includes_biological_process
|
{
"id": "C0040649",
"name": "transcription",
"pos": [
121,
134
]
}
|
{
"id": "C1328948",
"name": "rna synthesis",
"pos": [
199,
212
]
}
|
in this article we summarize results on the localized expression of keratin genes and on the reconstruction of regulated transcription of the gastrula/neurula-specific dg42 gene .
|
process_includes_biological_process
|
{
"id": "C0017262",
"name": "expression",
"pos": [
54,
64
]
}
|
{
"id": "C0040649",
"name": "transcription",
"pos": [
121,
134
]
}
|
the blockade of c-fos gene expression seen in antisense-cells could be caused by rapid degradation of the c-fos message , since c-fos mrna expression was rescued in these cells when treated with protein synthesis inhibitor , cycloheximide .
|
process_includes_biological_process
|
{
"id": "C0017262",
"name": "gene expression",
"pos": [
22,
37
]
}
|
{
"id": "C1515670",
"name": "mrna expression",
"pos": [
134,
149
]
}
|
although both genes reportedly use the same transcription fractions for in vitro rna synthesis , some of these drugs interfere differentially with these genes .
|
process_includes_biological_process
|
{
"id": "C0040649",
"name": "transcription",
"pos": [
44,
57
]
}
|
{
"id": "C1328948",
"name": "rna synthesis",
"pos": [
81,
94
]
}
|
this selective expression of beta keratin genes in specific regions of the developing scutate scale suggests that epidermal-dermal interactions provide not only for morphological events , but also for control of complex patterns of histogenesis and biochemical differentiation .
|
process_includes_biological_process
|
{
"id": "C0178679",
"name": "histogenesis",
"pos": [
232,
244
]
}
|
{
"id": "C0007589",
"name": "differentiation",
"pos": [
261,
276
]
}
|
these three cytokines act in concert to decrease food intake , increase resting energy expenditure , gluconeogenesis , glucose oxidation , and hepatic synthesis of fatty acids and acute phase proteins , decrease fatty acid uptake by adipocytes and alter the distribution of zinc , iron and copper .
|
process_includes_biological_process
|
{
"id": "C0014272",
"name": "energy expenditure",
"pos": [
80,
98
]
}
|
{
"id": "C0017715",
"name": "gluconeogenesis",
"pos": [
101,
116
]
}
|
analysis of these mutants indicates that the level of transcription from one promoter can affect the level of transcription from the other promoter and suggests that delta and his4 transcription signals compete for initiation of transcription from each site .
|
process_includes_biological_process
|
{
"id": "C0040649",
"name": "transcription",
"pos": [
54,
67
]
}
|
{
"id": "C1158830",
"name": "initiation",
"pos": [
215,
225
]
}
|
two regions necessary for high-level expression of the gene could be identified , a promoter-proximal domain immediately preceding the start of transcription and an enhancer domain which lies between 5 and 6.5 kilobases 3 ' of the polyadenylation site .
|
process_includes_biological_process
|
{
"id": "C0040649",
"name": "transcription",
"pos": [
144,
157
]
}
|
{
"id": "C0949765",
"name": "polyadenylation",
"pos": [
231,
246
]
}
|
9:273-277 , 1985 ) , the difference in expression of the two gene copies could be accounted for via differential transcription activity .
|
process_includes_biological_process
|
{
"id": "C0017262",
"name": "expression",
"pos": [
39,
49
]
}
|
{
"id": "C0040649",
"name": "transcription",
"pos": [
113,
126
]
}
|
analyses of cytoplasmic mrna stability , nuclear rna distribution , and transcription in the polyadenylation signal region indicated that the distribution of tk rnas ending at different poly ( a ) sites was the result of poly ( a ) signal choice , not other aspects of rna metabolism .
|
process_includes_biological_process
|
{
"id": "C0040649",
"name": "transcription",
"pos": [
72,
85
]
}
|
{
"id": "C0949765",
"name": "polyadenylation",
"pos": [
93,
108
]
}
|
the results show that ( i ) the functional origin of replication colocalizes with an autonomously replicating sequence element previously mapped to the nontranscribed spacer region , ( ii ) only a fraction of the potential origins are utilized in a single s phase , and ( iii ) the replication forks moving counter to the direction of transcription of the 37s precursor rna stop at or near the termination site of transcription .
|
process_includes_biological_process
|
{
"id": "C0040649",
"name": "transcription",
"pos": [
335,
348
]
}
|
{
"id": "C0597600",
"name": "termination",
"pos": [
394,
405
]
}
|
we studied the expression of the human dna polymerase alpha gene during cell proliferation , during cell progression through the cell cycle , and in transformed cells compared with normal cells .
|
process_includes_biological_process
|
{
"id": "C0596290",
"name": "cell",
"pos": [
72,
76
]
}
|
{
"id": "C1516334",
"name": "cell progression",
"pos": [
100,
116
]
}
|
these findings support the conclusion that the regulation of human dna polymerase alpha gene expression is at the transcriptional level and strongly suggest that the regulatory mechanisms that are operative during the entrance of a cell into the mitotic cycle are fundamentally different from those that modulate polymerase alpha expression in continuously cycling cells .
|
process_includes_biological_process
|
{
"id": "C0017262",
"name": "gene expression",
"pos": [
88,
103
]
}
|
{
"id": "C0040649",
"name": "transcriptional",
"pos": [
114,
129
]
}
|
however , behavioral decline begins before the appearance of significant numbers of senile plaques , suggesting that other factors may interfere with cognition .
|
process_includes_biological_process
|
{
"id": "C0004927",
"name": "behavioral",
"pos": [
10,
20
]
}
|
{
"id": "C0009240",
"name": "cognition",
"pos": [
150,
159
]
}
|
most materials showed an increased tensile strength and decreased elongation at failure for smaller suture gauges , and this behaviour is thought to be related to their internal molecular organization .
|
process_includes_biological_process
|
{
"id": "C0004927",
"name": "behaviour",
"pos": [
125,
134
]
}
|
{
"id": "C0039869",
"name": "thought",
"pos": [
138,
145
]
}
|
this sporulation deficiency of nonmotile mutants accompanies an altered pattern of gene expression , monitored by using transcriptional fusions of lacz to genes expressed at specific times during fruiting body development .
|
process_includes_biological_process
|
{
"id": "C0017262",
"name": "gene expression",
"pos": [
83,
98
]
}
|
{
"id": "C0040649",
"name": "transcriptional",
"pos": [
120,
135
]
}
|
since it would be reasonable to relate that response to motor behaviour , we evaluated the effect on the thalamocortical augmenting response of the stimulation of two other central nervous system structures which are also thought to participate in motor control , the cerebellum and the red nucleus .
|
process_includes_biological_process
|
{
"id": "C0004927",
"name": "behaviour",
"pos": [
62,
71
]
}
|
{
"id": "C0039869",
"name": "thought",
"pos": [
222,
229
]
}
|
examination of orthodromic responses of medullary rru to stimulation of this pathway revealed that most bulbospinal inspiratory neurons ( 10 out of 13 ) were paucisynaptically inhibited after short latency ( at least 1.2 ms ) .
|
process_includes_biological_process
|
{
"id": "C0035203",
"name": "rru",
"pos": [
50,
53
]
}
|
{
"id": "C0004048",
"name": "inspiratory",
"pos": [
116,
127
]
}
|
in general , feminine sexual development as measured by pubertal onset , reproductive organ weights and adult estrous cyclicity , was unaffected by perinatal exposure to cimetidine .
|
process_includes_biological_process
|
{
"id": "C0035150",
"name": "reproductive",
"pos": [
73,
85
]
}
|
{
"id": "C0025329",
"name": "estrous cyclicity",
"pos": [
110,
127
]
}
|
in order to assess perceptions of behavioral contagion of suicide ( what people thought a disturbed adolescent would do if the teen knew about a suicide in the community ) , and to assess actor-observer differences in such perceptions , 142 college students were asked to view a videotaped vignette of a distressed high school student , and then to assess her potential for committing suicide , running away , entering therapy , or abusing alcohol .
|
process_includes_biological_process
|
{
"id": "C0004927",
"name": "behavioral",
"pos": [
34,
44
]
}
|
{
"id": "C0039869",
"name": "thought",
"pos": [
80,
87
]
}
|
reproductive care of women with spinal cord damage demands knowledge of such women 's reproductive potential and the specific complications to which these women are prone during pregnancy and childbirth , especially autonomic hyperreflexia .
|
process_includes_biological_process
|
{
"id": "C0035150",
"name": "reproductive",
"pos": [
0,
12
]
}
|
{
"id": "C0032961",
"name": "pregnancy",
"pos": [
178,
187
]
}
|
the difference in precursor incorporation did not seem to be caused by differences in nucleotide metabolism but rather to reflect true differences in the rate of dna replication .
|
process_includes_biological_process
|
{
"id": "C0597108",
"name": "nucleotide metabolism",
"pos": [
86,
107
]
}
|
{
"id": "C0598312",
"name": "dna replication",
"pos": [
162,
177
]
}
|
gene expression in the polycistronic operons of escherichia coli heat-labile toxin and cholera toxin : a new model of translational control .
|
process_includes_biological_process
|
{
"id": "C0017262",
"name": "gene expression",
"pos": [
0,
15
]
}
|
{
"id": "C1519614",
"name": "translational",
"pos": [
118,
131
]
}
|
effective health education and behavior motivation programs are needed to promote the compliance of children and young adults with preventive health care practices .
|
process_includes_biological_process
|
{
"id": "C0004927",
"name": "behavior",
"pos": [
31,
39
]
}
|
{
"id": "C0026605",
"name": "motivation",
"pos": [
40,
50
]
}
|
the introns separating the variable and constant regions of active immunoglobulin genes contain tissue-specific transcriptional enhancer elements , dna segments which act in cis in an orientation- and distance-independent ( up to a few kilobases ( kb ) ) manner to enhance transcription initiation at adjacent promoters .
|
process_includes_biological_process
|
{
"id": "C0040649",
"name": "transcriptional",
"pos": [
112,
127
]
}
|
{
"id": "C1158830",
"name": "transcription initiation",
"pos": [
273,
297
]
}
|
isolation of this point mutation , outside of the transcribed region of car1 , suggests that expression of this gene is regulated at transcription .
|
process_includes_biological_process
|
{
"id": "C0017262",
"name": "expression",
"pos": [
93,
103
]
}
|
{
"id": "C0040649",
"name": "transcription",
"pos": [
133,
146
]
}
|
at 25 degrees c maximum sensitization was achieved in approximately 24 hr , cell proliferation was almost completely blocked , and cells gradually accumulated in the g2 phase of the cell cycle .
|
process_includes_biological_process
|
{
"id": "C0596290",
"name": "cell proliferation",
"pos": [
76,
94
]
}
|
{
"id": "C0079396",
"name": "g2 phase of",
"pos": [
166,
177
]
}
|
evolution from water to land breathing generally is associated with intermittent breathing , mass movement of gas in one direction , i.e . inhalation and exhalation .
|
process_includes_biological_process
|
{
"id": "C0035203",
"name": "breathing",
"pos": [
29,
38
]
}
|
{
"id": "C0004048",
"name": "inhalation",
"pos": [
139,
149
]
}
|
evolution from water to land breathing generally is associated with intermittent breathing , mass movement of gas in one direction , i.e . inhalation and exhalation .
|
process_includes_biological_process
|
{
"id": "C0035203",
"name": "breathing",
"pos": [
29,
38
]
}
|
{
"id": "C0231800",
"name": "exhalation",
"pos": [
154,
164
]
}
|
due to the central role played by the fc-receptor function in host defence mechanisms , including phagocytosis as well as antibody dependent cellular cytotoxicity , the capacity of levamisole to restore defective neutrophil fc-receptor function in cancer patients could contribute to the `` '' immunomodulating '' '' effect of the drug .
|
process_includes_biological_process
|
{
"id": "C0520990",
"name": "function",
"pos": [
50,
58
]
}
|
{
"id": "C0031308",
"name": "phagocytosis",
"pos": [
98,
110
]
}
|
we conclude that the expression of the three genes cloned in the secretion vector was similar at the levels of transcription and translation in b. subtilis .
|
process_includes_biological_process
|
{
"id": "C0017262",
"name": "expression",
"pos": [
21,
31
]
}
|
{
"id": "C0040649",
"name": "transcription",
"pos": [
111,
124
]
}
|
transcription of variant 5 s rna genes has indicated that a region of the gene extending from residue +57 to residue +99 is essential for directing specific initiation of transcription .
|
process_includes_biological_process
|
{
"id": "C0040649",
"name": "transcription",
"pos": [
0,
13
]
}
|
{
"id": "C1158830",
"name": "initiation",
"pos": [
157,
167
]
}
|
through these observations describe only the behavior of subcortical [ ca2+ ] i , we suggest that our data represent the subcortical extension of the cortical ca2+ wave thought to trigger cortical granule exocytosis , and we present evidence that both the timing and magnitude of the ca2+ pulse we observed are consistent with this identity .
|
process_includes_biological_process
|
{
"id": "C0004927",
"name": "behavior",
"pos": [
45,
53
]
}
|
{
"id": "C0039869",
"name": "thought",
"pos": [
169,
176
]
}
|
although maintaining the b cell differentiation-inducing quality of its progenitor molecule , the fc gamma fragment , p23 appeared to have lost the ability to induce b cell proliferation .
|
process_includes_biological_process
|
{
"id": "C1511002",
"name": "b cell",
"pos": [
25,
31
]
}
|
{
"id": "C1155008",
"name": "b cell proliferation",
"pos": [
166,
186
]
}
|
in view of the previously shown effect of thymus on bursa development , these data suggest that the maturation of ti-1 antigen ( tnp-f ) -respondent chicken b cells requires residence in both the bursa and spleen before the development of responsiveness to such antigens .
|
process_includes_biological_process
|
{
"id": "C0678723",
"name": "maturation",
"pos": [
100,
110
]
}
|
{
"id": "C1519473",
"name": "spleen",
"pos": [
206,
212
]
}
|
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