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veles excellence hub strengthening the southeast europe smart health regional excellence and boosting the innovation potential
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smart health is eu strategic value chain that contributes to growth jobs and competitiveness health data is the main enabler for the value chain but it also depends on cutting edge technologies ai cloud computing iot to integrate the dispersed knowledge and support innovative healthcare solutions and services ec sets the creation of a european health data space as a main priority to promote better exchange and access to health dataon a regional level the ris3 strategies of the involved widening countries bulgaria romania greece and cyprus emphasize the need for based on big data ai and iot digitalized healthcare to enable personalized medicine informed decisions and improved disease prediction ris3 strategies also outline the need for more funding for ri policy coherence and development of territorially join innovation strategies a cross country coordinated approach is needed to align the separate endeavours towards an excellent southeast europe smart health innovation ecosystem enabled by a regional smart health data spaceveles raises the level of innovation excellence in the southeast eu through creating a sustainable placebased innovation ecosystem enabled by regional smart health data space including novel transformational framework ri and investment strategy and action plan for research development and adoption of innovative and secure digital solutions that underpin the delivery of sustainable healthcare services the regional smart health data space will be demonstrated through the design of 4 interrelated pilots on cancer treatment greece personalisedprecision medicine of alzheimer bulgaria cerebral tumours romania and dementia cyprus the aim of veles is to foster health data sharing regional and national strategies to secure improved clinical practice to preserve patients privacy and to empower citizens smart healthcare through access to innovative cyber secure and data driven digital health services
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measuring irregular migration and related policies
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targeted policy responses for irregular migration require better knowledge about the characteristics of the irregular migrant population and dynamics of irregular migration as well as about the effects of policy measures yet quantitative data relating to irregular migration are scarce often outdated and contested the inadequecy of current data makes it challenging for stakeholders to develop and monitor policies how do legal frameworks in different countries define migrant irregularity what are the characteristics of irregular migrants in terms of age gender nationality or other socioeconomic variables how can the effects of policy measures such as regularisation be assessed mirrem adresses the challenge of insufficent knowledge about irregular migration and regularisation in europe by actively involving relevant stakeholders in every stage of this project as cocreators of its results and as stakeholders to its mission in a rigorous comparative and multilevel study we will assess the policies data needs and estimates that define migrant irregularity in 11 eu member states the uk canada the usa and five transit countries using several coordinated pilots we will develop new and innovative methods for measuring irregular migration and regularisation scenarios and we will explore if and how these instruments can be transferred or scaled up to other socioeconomic or institutional conditionsbased on these insights we will develop two public databases a a database with estimates on irregular migrant stocks and b a database on irregular migration flows that will also include data on regularisations together with the expert groups we will synthesize our findings into a handbook on data on irregular migration and a handbook on regularisation that will support evidencedbased and targeted policymaking concerning irregular migration finally we will develop training resources for policymakers practitioners journalists and earlycareer researchers
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accelerating relational databases with real memristive processinginmemory
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in the contemporary digital era relational databases play a pivotal role in business applications facilitating the management and analysis of intricate data sets in diverse sectors including healthcare finance and social media platforms these databases comprise relations represented as sets of records and attributes allowing for detailed data scrutiny and insightful business decisionmaking however the prevalent model of data analysis is beleaguered by lengthy execution times and considerable energy consumption due to the separation of data processing and storage necessitating hefty computational investmentsaddressing this we propose an innovative approach leveraging processinginmemory pim techniques specifically bulkbitwise pim to hasten analytical processing in relational databases grounded in emergent nonvolatile memristive memory technologies this method capitalizes on memory cell arrays for concurrent data processing and result storage markedly diminishing data movement and consequently time and energy expenditure our endeavor is to craft the memristive memory processing unit mmpu originally developed during the pis erc stg realpimsystem project adept at accelerating relational database analysis promising to deliver a computing system that is tenfold faster and a hundred times more energyefficient at a fraction of the current cost revolutionizing data analysis and offering substantial savings in both time and financial resources
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cobenefits and synergies between biodiversity conservation poverty alleviation and climate change mitigation from a socialecological systems perspective
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cobiopovcli addresses the question of how to conserve biodiversity alleviate poverty and mitigate climate change simultaneously which are interrelated challenges that threaten human and environmental wellbeing the importance of this topic is highlighted by the current context of the global covid19 pandemic and the russiaukraine war which have exacerbated these problems and their impacts on human and environmental wellbeing the main gaps in this topic are 1 lack of comprehensive data especially on the dynamics of socioecological systems 2 lack of integrated knowledge and 3 lack of holistic approaches that consider cobenefits and synergies cobiopovcli aims to overcome the limitations and gaps in the current stateoftheart by developing an integrated spatial planning approach that can achieve winwin synergies between biodiversity conservation poverty alleviation and climate change mitigation from a socialecological systems perspective cobiopovcli will use literature models remote sensing data and other data sources to construct and apply the spatial planning approach based on case studies spatial analysis and scenario simulation cobiopovcli will generate new knowledge data and solutions that are conceptually novel scientifically rigorous and policyrelevant it will enhance our understanding of the multiple values of biodiversity and its contributions to human wellbeing under changing climatic conditions it will provide evidencebased recommendations and best practices for promoting more integrated and sustainable approaches that benefit both people and the planet cobiopovcli will also enhance europes scientific and technical capacity and excellence in the field of cobenefits and synergies between biodiversity conservation poverty alleviation and climate change mitigation as well as contribute to europes global leadership and influence in addressing these interlinked challenges
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satellitebased change detection and predictive monitoring of infrastructure grids based on high resolution data
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liveeo will offer a holistic monitoring service for infrastructure networks based on satellite data and machine learning algorithms to identify external threats to the grid and predict future impacts by adding time series analytics to our services the service will enable rapid change detection eg storm monitoring to quickly assess the location and extent of damage and slow change detection to facilitate the prediction of potential risks we will make use of optical and radar data to offer services in real time regardless of weather the solution requires the development of aibased change detection algorithms that evaluate data at different points in time ie timeseries and are able to detect patterns and abnormalities in the data with high precision to do this automatically the development of an automated process chain able to transform data into actionable insights for our customers is part of the solution insights will be made available via mobile and web apps
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selective alkylation of complex molecules in flow
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developing new pharmaceuticallyactive molecules for the treatment of diseases that compromise the health and wellbeing of society is an essential but tedious process with rising costs partially due to the arduous chemical synthesis of complex drug candidates recently innovations in organic chemistry have streamlined the access to vast libraries of drugs by applying novel methodologies such as latestage functionalization of ch bonds however one of the major challenges of editing biologicallyactive chemical structures is the development of processes that are compatible with diverse functional groups and functionalize one single position la carte in an efficient and predictable mannerselectflow presents a multidisciplinary project that lies in the intersection of synthetic photoredox catalysis with microfluidic technologies with the objective of delivering a selective sustainable and predictable methodology for the modification of biologicallyactive molecules using light alkanes as raw materials this will require the accomplishment of three specific objectives 1 development of a chemo and regioselective synthetic methodology for the edition of nitrogencontaining aromatic heterocycles 2 translation of the developed photocatalytic system into a microflowbased setup to enable the use of gaseous reagents in a milder and scalable fashion 3 understanding the mechanistic intricacies of the developed methodology in order to predict unexplored similar transformations overall this proposal directly tackles one of the most important challenges for the pharmaceutical industry the rapid and costeffective production of innovative drugs by delivering a sustainable valorisation of greenhouse gases such as methane it is expected that this innovative approach will be of high scientific technological and societal impact ultimately reinforcing the already european competitiveness in the production of lifesaving drugs
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regulation of early colorectal cancer tumorigenesis by nutrient signalling of intestinal stem cells and their tissue environment
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colorectal cancer crc is the second most common cancer and nutrition influences its prevalence crc originates from intestinal stem cells iscs and is initiated by specific genetic alterations which influence cell growth proliferation and fate how nutrient signalling within the mutated iscs and the surrounding tissue environment influences the early steps of crc tumorigenesis and whether genetically distinct tumour types react differently to nutrition remains poorly understood the host laboratory has recently discovered a mechanism that couples nutrientdependent control of isc size to cell fate regulation as distinct tumorigenic genotypes display different fate profiles i hypothesise that nutrientdependent control of isc size differentially modulates phenotypes of crcassociated gene variants to test this i will utilise the drosophila midgut model as well as the fully defined drosophila diet to systematically uncover the nutrient vulnerabilities of several iscderived tumorigenic genotypes as my preliminary data implicates the role of nutrient signalling in the tissue environment i will develop a new dual gene expression tool enabling simultaneous genetically control of the tumour and the neighbouring tissue i will combine transcriptomics metabolomics and organwide imaging with quantitative image analysis to mechanistically address how changes in nutrient signalling and metabolism of oncogenic and surrounding wildtype cells influence tumour initiation to test the conservation of the main findings in drosophila i will utilise the crc models of mouse intestinal organoids collectively this project will address how nutrient regulation of iscs and their tissue environment will affect the initial events of crc tumorigenesis
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territorial and regional demonstrations of systemic solutions of key value chains and their replication to deploy circular economy
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treasource will innovatively circulate currently incinerated exported landfilled or dumped plastic and biobased side and waste streams by deploying systemic circular economy ce solutions the systemic ce solutions will integrate the two main elements of treasource stakeholder engagement demonstrations sedemos and key value chain demonstrations kvcdemos the demos support chosen territory clusters in introducing ce practices to their citizens and businesses to help 1 decouple from use of fossil virgin resources and excess raw material consumption 2 increase resilience selfsufficiency value chain security environment and nature 3 decrease ghg emissions and contribute to achieve climate neutral economies climate change environmental degradation and loss of biodiversity are major global threats that require urgent collaborative actions across industry sectors cities and regions communities and citizens half of total ghg emissions and more than 90 of biodiversity loss come from resource extraction and processing global consumption of materials especially biomass fossil fuels metals and minerals are expected to double by 2060 and annual waste generation is estimated to increase by 70 by 2050 treasource focuses on demonstrating the ce solutions in cities and regions located in the nordics finland sweden norway and denmark and they will be replicated in the baltics estonia latvia lithuania poland and germany of the baltic sea region the combination of the cities and regions will enable large reach and bigger impact and boost the replicability and scalability potential of the ce solutions a common issue of the regions material circulation is low and decentralised material volumes and resulting challenges in feasibility and bottlenecks have been high risk investments due challenges in securing sufficient feedstock quality and quantity however regional strengths lie in ambitious climate and environmental targets
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harnessing evidence on adverse drug withdrawal events following deprescribing through the pharmacovigilance system headp
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deprescribing reducing or stopping unnecessary or harmful medications is an important strategy to reduce the risk of medication harm a significant and growing challenge for health systems as acknowledged by the world health organization the aim of headp is to establish the current evidence base on adverse drug withdrawal events adwes and explore how this can be enhanced via the pharmacovigilance system headp consists of 4 research objectives to assess the rate of adwes in published trials of deprescribing to examine the incidence of adverse events reporting related to adwes to identify and review all recommendations related to the monitoring detection and reporting of adwes and to investigate healthcare professional patient and policymaker perspectives on the integration of adwe reporting in the pharmacovigilance system the following research approaches will be employed an umbrella review of systematic reviews disproportionality analysis of key pharmacovigilance databases a scoping review of sources of guidance and qualitative semistructured interviews this innovative research will help address the significant gap in our knowledge of adwe occurrence and will stimulate future studies and innovations moreover this fellowship will provide me with valuable scientific protocol development quantitative data analysis relevant to pharmacovigilance data qualitative research methods data management and synthesis skills and transferrable grant writing research communication and supervision and mentoring skills skills it will also provide me with valuable international intersectoral and interdisciplinary experience and allow me to develop leaderships skills the skills and experience i will gain by completing this fellowship in the host organisation rcsi will help me achieve my ultimate career goal to become a leader in pharmacovigilance research and development in academia or a medicines regulatory agency
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a new eu framework for an ethical reuse of health data
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the eu has recently enhanced the potential of health data in the eu digital market by promoting a number of initiatives and new regulations to facilitate data sharing and reuse among public institutions the forthcoming provisions of the digital strategy corpus of law these in combination with preexisting rules and practices of health data exploitation might sharpen the risks for citizens for example allowing public bodies to exploit big data sets to make detrimental decisions regarding the access of certain patients to health care eg in the case of insurancebased systems in this context academic analysis is urgently needed as well as suggesting a revision of the new regulations to eu policymakers to facilitate responsible data sharing datacom aims at building a new framework to facilitate an ethical secondary use of health data held by public bodies with the aim of improving accountability and enhancing responsible reuse to build it i will develop and test in intersectoral practical environments the innovative concept of ethical commodification the possibility of exploiting personal data in an ethical way for the public good in accordance with the data subjects expectations and needs and taking into account the risks associated with the exploitation of anonymized data sets focusing on 3 member states italy spain and the netherlands in order to reach this objective datacom has a strong interdisciplinary and intersectoral approach bridging law ethics and computer science taking into consideration the needs of the public sector and those of citizens to ensure the successful implementation of these project goals i will conduct my research at the university of turins law department with the guidance of prof ugo pagallo a leading scholar this project will prepare me to become a tenured scholar and obtain advanced funding strengthening my academic profile and allowing me to establish my own research group
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polin the political conditions of interoperability in european digital health policies
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the polin projects aim is to explore the political condition of interoperability in european digital health policies interoperability refers to the ability of computer systems to work together even if they are created by different business or state organizations interoperability standards are key to the creation of efficient digital health infrastructures in particular at the european level for instance electronic health records are expected to be available everywhere in the european union flowing within a harmonized european health data space if the technical conditions of interoperability have been extensively explored little is known about the political conditions under which various actors pursuing complex agendas may be willing to adopt common standards indeed standard selection in digital health is guided by many different industrial medical political legal and ethical considerations therefore the aim of this project is to explore the political conditions favoring or impeding the adoption of interoperability standards in eu digital health as digital cooperation marks a turning point for the future of eu integration this proposal will contribute to open a new research agenda aiming to explore how the eu is able to govern through project cooperation furthermore interoperability choices reflect highly sensitive and political decisions which are not trivial and are likely to deeply transform the lives of eu citizens this project therefore intends to contribute to the adoption of better inclusive digital health standards this msc fellowship will be key in strengthening my skills in european studies as i will be guided by a renowned expert in european decisionmaking processes prof stephanie novak in addition the host institution ca foscari university will provide me with many opportunities to acquire new transferrable skills and to develop the interdisciplinary aspect of my research
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reusable mask patterning
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surface patterning is crucial for the progress of key enabling technologies kets such as advanced manufacturing microelectronics nanobiotechnology and photonics the current paradigm in surface patterning is optical projection lithography opl a paradigm designed for highresolution however emerging green technologies like micropatterned photovoltaics pv require high quality patterning at scalethroughput that is hardly attainable by opl economically and sustainably importantly halfpitch resolutions on the tens of mscale are totally acceptable for such applications which does not justify the use of highend opl in these cases opl is unsuited because it relies on disposable masks with extremely high embodied energy while the key asset of opl is the mask it is the component that currently makes it lowthroughput and energymaterial inefficient extensive efforts have been directed to develop maskless strategies but most fall short when it comes to throughput and design flexibility remap envisions a radically new and green surface patterning technique based on the spontaneous formation of reusable magnetic masks such masks are possible using fully adjustable and reversible interactions of magnetorheological electrolytes mre on a substrate and microstructured magnetic fields generated by a permanent array of electromagnets below the substrate by selectively activating each microelectromagnet it is possible to modulate the intensity and shape of the magnetic field hence the mask over space and time this way remap enables highthroughput areaselective additive and subtractive patterning on a surface at room temperature and pressure furthermore the newly devised mres and the tuneable magnetic array developed within remap will pave the way to a plethora of future applications from labonachip biomedicine nmr analysis and smart fluids for robotic space exploration
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a new perspective on city logistics concepts theory and models for designing and managing logistics as a service
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several social economic and technological trends are coming together to revolutionize the way people products and services are brought together goods are gaining more mobility with drastic implications for cities the current city logistics cl paradigm which does not consider the mobility of goods a public need limits our capacity to understand and respond to the challenges and opportunities brought by this profound change taking a different perspective goodmobility proposes to replace the technobusinesscentric smart thinking with networkcentric wise logistics that takes the public value as the primary goal and envisions setting up a logistics web with the required infrastructure hardware and operating procedures software to establish logistics as a service laas the first objective is to develop public value as a measurement system to assess and guide cl planning and management which will be achieved with an iterative process combining multicriteria decision making sustainability analysis simulation and optimization the second objective is to develop the principles models and tools for laas infrastructure design novel network optimization methods will be developed for designing the hardware of laas to provide orders of magnitude efficiency gains and influence the stakeholder activities to maximize public value the third objective is to develop a theoretical framework and models for the operating procedures of laas introducing the logistics markets to ensure efficiency and reliability and secure public value in matching logistics demand and supply learningbased optimization methods will be developed to manage logistics markets if successful goodmobility will lay the foundations of a new theory of cl with significant scientific and practical implications the novel ideas concepts and methodologies will open up new research perspectives in transport and logistics with farreaching social economic and environmental consequences
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functional nanoscaffolds for regenerative medicine
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repair or replacement of tissue and organ functions lost due to age disease or damage represents one of the most urgent medical needs of our aging society the nanoremedi consortium will contribute to addressing this fundamentally important issue by using a new and efficient scientific approach relying on the design preparation characterization and validation of conceptually innovative peptidebased functional nanomaterials for regenerative medicine applications specifically nanoremedi will tackle three highly relevant case studies tissue engineered vascular grafts to replace damaged peripheral arteries stemcell based regenerative medicine for bone and cartilage repair and facing with implantation failure this last addressed to overcome bacterial severe infections as an equally important goal the nanoremedi consortium aims to build a worldclass doctoral educational model in the field of nanomaterials applied to regenerative nanomedicine through a strategically designed academiaindustry interplay to this end 6 beneficiaries one associated partner linked to a beneficiary and 12 nonacademic associated partners will join their forces to icreate a highly innovative research network for training a new generation of 13 doctoral candidates dcs with strong employment potential aimed at studying and developing functional nanoscaffolds for regenerative medicine iiestablish a robust structure for longterm research cooperation between a pool of leading universities and enterprises for broadening and strengthening the knowledge and skills of dcs accessing the nanosciencearea from adjacent disciplines such as chemistry material sciences and bioinformatics iiibuilding a solid foundation for longterm european excellence in medical nanotechnology via dissemination of researchtraining outcomes through crossnetwork secondments summer schools workshops and transferable skills modules and of the best practice generated by nanoremedi
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metabolic fingerprinting of autism spectrum disorders in breath by mass spectrometry
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current diagnosis of individuals suffering from disorders on the autism spectrum is based on behavioural and developmental observations usually in their early life even so there is a significant amount of people having to live with these lifelong disorders that remain undetected and no treatment is provided to them however it is already established that such disorders are associated with metabolic changes there is now a growing amount of evidence suggesting that such metabolicalterations can be detected in samples such as blood or urine taken from children early in their life these routines however can cause significant discomfort to the childthe primary aim of the proposal will involve the use of less invasive sampling techniques such as exhaled breath and exhaled breath condensate for the early diagnosis of metabolic hallmarks of autism spectrum disorders these samples will be analysed using already established chemical analysis techniques for the detection of small metabolic changes in the obtained samples tandem mass spectrometry techniques will be used for the unambiguous identification of these metabolites data analysis tools such as principal component analysis pca and hierarchical clustering will be used to associate these metabolic changes with existing medical records obtained from the patients to establish a potential diagnostic toolthe potential for the rapid detection of these metabolites will be examined through the integration of novel ambient mass spectrometric ionisation methods such as plasma ionisation the ability to selectively ionise specific metabolites associated with autism will be investigated with the aim of generating an early prototype of a rapid screening method for routine use data generated during the initial stage of the work will be used to create a database that will be used for near realtimecharacterisation of the exhaled breath through the analysis of metabolites and volatile organic compounds vocs
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advanced strategies for development of sustainable semiconductors for scalable solar cell applications
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solarup directly addresses the ever louder call for sustainable energy production the proposed solar energy conversion technology will reduce dependence on critical raw materials and overcome efficiency thresholds to unlock the future of flexible photovoltaic pv solar cells for mass deployment in smart buildings soft robotics wearable electronics and other consumer products our main innovations lie in nanoengineering zinc phosphide zn3p2 for use as an earthabundant direct bandgap semiconductor absorber and combined with a novel device architecture we target cell efficiency enhancements of up to 15 advanced manufacturing techniques such as nanoimprinting and metalorganic vapourphase epitaxy will be explored to open industrially scalable routes to synthesise high quality zn3p2 films moreover our approach will allow reuse of the growth substrate making sustainability another core element of solarups radical vision optimisation of both the absorber structure and device architecture will be achieved through a holistic interplay of firstprinciples calculations and atomic scale structural and electronic characterisation the main outcome of solarup will be the demonstration of an ultrathinfilm pv technology that is scalable costeffective and environmentally sustainable complete with a comprehensive life cycle analysis in this sense our aim is to feed and inspire the development of zn3p2based solar cells towards a market ready technology the project consortium unites six european teams with complementary expertise at the forefront of zn3p2 research device architecture and life cycle analysis who will approach the ambitious challenges from a flexible and interdisciplinary perspective solarup has clear potential to make sciencebased contributions to energy security and highquality job creation while also connecting to industry and boosting the trajectories of earlycareer team members
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quantumoriented update to browsers and infrastructures for the pq transition
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the exciting frontiers opened by the development of quantum computers qc come at the cost of breaking the foundations of current digital security the research community is working to the definition of postquantum cryptography pqc to counteract this threat however the transition to pqc is delicate and takes time because it impacts many functions algorithms and protocols in apriori unknown cascade of dependencies qubip is conceived to contribute to the eu transition to pqc with the goal of simplifying and making replicable the process by means of recommended practices and counteract postquantum threats as soon as possible qubip focuses on digital infrastructure addressing the 5 main building blocks that use publickey cryptography for security purposes hardware cryptographic libraries operating system communication protocols and applications qubip address all 5 blocks coherently solving all dependency issues that may arise inside each block and among blocks with the final aim to validate at trl6 three infrastructures making use of those blocks in iotbased digital manufacturing internet browsing and software networks environments for telcos use cases the returnofexperience from the three practical exercises is then maximized by developing a migration playbook that will contain the lessons learned and an evaluation of all the technical economic and legal barriers encountered together with the solutions to overcome them to enable the definition of a replicable process suitable to provide structured accompanying and practical guidance to industrial stakeholders the technical activities are corroborated by three supporting activities i evaluation of the capabilities of qcs to assess their implication to primitives algorithms and protocols adopted and contribution to ii standardization efforts addressing transition to pqc processes and iii policy measures addressing technology changes coming from the advent of qc and pqc
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embedded ai systems and applications
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embedded artificial intelligence ai has emerged as a transformative technology with immense potential to revolutionise various domains spanning from robotics and healthcare to environmental monitoring and the internet of things this doctoral network dn project ant aims to train a network of 15 excellent doctoral candidates dcs by addressing the fundamental challenges of embedded ai and accelerating the development of embedded ai systems and applications through an innovative and interdisciplinary research and training program ant consists of four interconnected work packages wps that encompass different aspects of embedded ai wp1 tackles the challenges in designing lowfootprint standalone embedded ai models under resource constraints and with diverse contexts and evolving environments wp2 goes beyond standalone embedded ai and designs innovative distributed and scalable learning solutions for heterogeneous embedded ai networks under energy and bandwidth constraints wp3 enhances the trustworthiness of embedded ai with explainability robustness security and privacy ant concludes in wp4 with a concerted effort to transfer fundamental research contributions to industryrelevant applications in autonomous robotics underwater iot mobile healthcare and smart farming boosting europes position in the global ai market both from a talent and a technological perspective these interdisciplinary and interdomain research training along with the comprehensive softskills training spanning from presentation skills to intellectual property marketing and economics etc will make ants 15 dcs highly employable in various industries academia or public government bodies and will position the eu at the forefront of the emerging revolution of embedded ai on things
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targeting rna with small molecules
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rna molecules play key roles in biological processes and diseases an emerging avenue to develop innovative medicines is therefore to design small molecule drugs that bind to rna and affect downstream biological functions however to advance this field of research a new generation of scientists is needed that can further develop and ultimately master the challenging process of drug design applied to rna therefore the targetrna network aims to educate and nurture the next generation of scientists with cuttingedge interdisciplinary skills in the discovery and biological characterization of rna modulators and thus generate fundamental knowledge on what drives affinity and specificity of small molecules binding to rna the objective of targetrna is to develop compounds with antimicrobial activity through their interaction with rna targets and to use these to selectively reshape the human gut microbiome an area with vast implications for medicine training through research activities spanning from computational and medicinal chemistry over structural and molecular biology to microbiology and in vivo models will be supplemented by an innovative training programme in specific and transferable skills for interdisciplinary drug discovery strategies to target rna including fair data principles open science practices as well as responsible development and sustainable implementation of new innovations to achieve the ambitious research and training goals the targetrna network unites leading scientists from 13 academic partners 8 beneficiaries 5 associated and 4 industry partners 1 beneficiary 3 associated based in 9 countries
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volatolomic approaches for improving success rates in assisted reproductive technology
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volatolomics has emerged as a new frontier in deciphering unreached matters related with health conditions volatolomics research is based on the study of the volatile compounds emitted by biological samples it was demonstrated that the volatiles emitted though breath skin feces urine or cells can provide useful information for the diagnosis of an important number of diseases such as cancer diabetes or even neurodegenerative disorders we have very recently demonstrated that the embryos do also emit volatiles during their development while genetical disorders alter the pattern of the released volatiles in the present project we aim at assessing volatolomic techniques for the noninvasive assessment of embryos quality in order to select the most viable ones for transfer the ultimate goal of this project is to achieve higher success rates in the in vitro fertilisation
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2ps prevent protect through support
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the european commissions latest strategy for fighting child sexual abuse highlights a harsh reality that globally we are losing the battle against online child sexual abuse and exploitation ocsea various projects funded through the eu are working diligently to identify the source of csam on both the clearnet and darknet and are establishing stronger awareness of the needs and requirements of leas to fight the overloading volume of images text media files etc however the iocta 2021 report also brings a chilling honesty that the prevalence of materials shows no sign of slowing or stabilising the adage that prevention is better than the cure never seemed more fitting the 2ps project condemns all forms of sexual abuse and exploitation and there are no excuses that justify behaviours and actions that harm or victimise children however to reduce the number of abused children and those at risk of exploitation we need to address various challenges several of those relate to people with a sexual interest in children and their needs to divert them from abusing 2ps which stands for prevent protect through support is a highly innovative action offering a paradigm shift in the approach to tackling child sexual abuse and exploitation csae across europe the highly qualified and diverse consortium together with leading global actors are committed to laying the foundations for new coherent modus operandi that complement the reactive approaches currently favoured this is achieved by addressing the support needs of people with a sexual interest in children and people who feel they might offend we will share the best practices for guidance therapy and treatment methods combined with new training and awareness for frontline support workers and leas we aim to move preventive actions to the forefront offering alternative courses of action to existing offenders and people who fear they might offend including people with a sexual interest in children
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curing contaminated and saline land with industrial crops and producing biomass for highvalue applications
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iasis aims at providing solutions for curing both contaminated and saline land through phytomanagement selected highyielding nonfood industrial crops will provide biomass feedstock to develop intermediate and end bioproducts following a cascading biorefinery approach via economicviable value chains farmers will have an active role on how to remediate the contaminated andor saline soils while generating additional income by providing sustainable feedstock for nonfood valueadded applications in order for the main and specific objectives to be fulfilled a total number of 6 work packages have been designed the work starts with the crops optimisation improved genotypes and phytomanagement strategies microbial consortia development wp1 for both contaminated and saline soils that will be tested and validated both in lab scale and in field case studies fcss fcss will be set up wp2 in eight sites in europe 4 contaminated and 4 saline where 8 highyielding nonfood industrial crops will be grown following lowinput and phytomanagement practices to produce feedstock for the value chains and the bioproducts development wp3 as well as to engage and train the farming community wp2 two main groups of bioproducts will be developed wp3 based on the type of industrial crops exploited oilseeds and lignocellulosic and in total 10 intermediate and 10 endproducts will be developed and tested sustainability and feasibility assessment will be carried out on the most promising biomasstoproducts pathways wp4 a decision support system to assess the viability and the soil remediation of the proposed value chains and applicable business models will be developed tailored to the iasis needs that will be applied for the iasis case studies but will be applicable beyond the project the regulatory framework will be outlined while policy recommendations will be proposed wps 5 6 are dedicated to project dissemination and coordination
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numerical modeling of cardiac electrophysiology at the cellular scale
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cardiac function is coordinated by an electric system whose disorders are among the most frequent causes of death and disease numerical models of this complex system are mature and widely used but to match observations in aging and diseased hearts they need to move from a continuum approach to a representation of individual cells and their interconnections this makes the problem more complex harder to solve and four orders of magnitude larger necessitating exascale computersthe eurohpc2019 microcard project is developing a simulation platform that can meet this challenge by a joint effort of hpc experts numerical scientists biomedical engineers and biomedical scientists from academia and industry our proposal is to establish a centre of excellence that will consolidate and scale up the microcard results enabling digital twins of cardiac tissuewith a consortium gathering the core partners of microcard we will further develop microcards numerical schemes moving to secondorder spatial discretization based on microcard results we will develop mixedprecision preconditioners and data compression to reduce communication bandwidth the highly successful efforts towards automated compilation of highlevel model descriptions into optimized energyefficient system code for different cpus and gpus will be extended to upcoming architectures we will continue efforts to robustify parallel remeshing software and add necessary functionality for parallel mesh partitioning and production of realistic synthetic tissue meshes needed for simulationsthe platform will be benchmarked with realistic test cases and be made accessible for a wide range of users with tailored workflowsthe platform will be adaptable to similar biological systems such as nerves and several of our products such as improved solvers preconditioners remeshers and partitioners will be reusable in a wide range of applications
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deepinelasticscattering and vectorbosonfusion advances
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the large hadron collider lhc probes interactions among particles with unprecedented precision the determination of the higgs boson properties is a central pillar of the lhc physics program and of the current lhc runthis demands for accurate theoretical predictions which usually hinge on monte carlo event generators stateoftheart predictions are given by nexttoleadingorder nlo calculations in qcd matched to leadinglogarithmic ll parton shower ps nexttonlo nnlo matching necessary to advance the accuracy of theoretical predictions is limited to specific processes like the hadroproduction of heavy systems in the final statevector boson fusion vbf is the preferred channel for the determination of the higgs to muon couplings and for higgs to invisible searches this projects aim is to pioneer nnlo matching techniques for processes characterised by the tchannel exchange of a colourless boson such as vbf and vector boson scattering vbs and to develop the first nnlops generator for higgs boson production in vbfgiven the close relationship between higherorder corrections in vbf vbs and deep inelastic scattering dis the initial focus will be the formulation of a nnlops matching scheme for dis this matching will preserve the logarithmic accuracy of both the new nextto ll nll showers and the standard ll ones additionally to achieve this task novel resummed predictions for dis will be produced reaching nnlonll accuracy within a comprehensive ps simulation is a groundbreaking endeavourthese outcomes will be vital for precise studies of the higgs sector in the current and future lhc runs and for highprecision investigations at future distype facilities like the electronion collider furthermore this project will lay the foundations for a more widely applicable nnlops matching approach with superior logarithmic accuracy which can be extended to a broader range of collider processes involving qcd jets
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twofaced hopes football migration and religion between west africa and europe
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since the 1990s and the commercialization of global football an increasing number of young people in countries like ghana ivory coast and cameroon have aspired to play football as a career a strategy to migrate abroad ideally europe and an opportunity for social and class mobility for the majority however the dream does not come true international media and human rights organizations regularly report about thousands of young west africans victimized by deceitful agents stranded as undocumented migrants and playing for clubs under exploitative conditions and yet young people continue to train to migrate and play scholars have studied these footballrelated migrations but they have overlooked the fact that religions especially pentecostal christianity and islam play a central role in migrants hopeful journeys this project investigates the intersection of football migration and religion among african migrants in europe in order to study hope conceptualized as a belief that something desired may occur in the future it makes a crucial critical intervention while many interdisciplinary studies assume a depoliticized notion of hope and romanticize its positive and constructive qualities janushope also examines the dark side of hope that perpetuates inequality and exploitation it turns to african irregular football migrants in europe to understand how a critique of the global industrys dark side of hope might coexist with hopes for making it in the industry it investigates how their faithbased narratives of hope might both critique and reproduce inequalities of global capitalism and transnational migration the key research methods are semistructured interviews and ethnographic fieldwork with irregular african football migrants in europe the results will be disseminated through refereed articles and communicated to a wide global audience interested in football and to key european policy makers in fields of migration and human rights
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personalized adjuvant treatment for hrher2 breast cancer for young patients
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worldwide 7 million women live with or beyond breast cancer bc as 10year survival rates exceeding 80 for earlystage iiii bc premenopausal bc accounts for 25 in the eu and 55 in lowmiddle income countries most premenopausal women with bc have high risk of recurrence therefore standard treatment includes adjuvant chemo ct and endocrine therapy et however treatment has substantial physical emotional and social burden which is often more pressing for younger compared to older patientsgeneexpression assays are used for postmenopausal patients to identify women who can safely forego ct without detriment on clinical outcomes preserving quality of life qol however a definitive study has yet to be conducted among premenopausal women with highrisk hrher2bc the primary objective of pathforyoung is to conduct a pragmatic randomized controlled trial rct with 5000 patients validating the use of a geneexpression assay to drive adjuvant treatment decisions in this target populationpathforyoung aims to achieve its objective in 7 years the project i builds on and complements an ongoing twin rct to ensure timely recruitment ii leverages on a large international consortium of oncologists pathologists patient representatives psychologists sociologists ethics and communication experts biostatisticians health economists and technology providers to assure complementary and multidisciplinary expertise and iii highlights patientengagement participatory care and early involvement of end users pathforyoung will also study implementation of digital selfmanagement to support patients throughout the cancer journey and particularly while on et to improve qol and medication adherence a full hta will ensure a path towards crosscountry implementationpathforyoung has the ambition to improve bc care fully integrating the predictive personalized preventive and participatory principles of health management
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supplementum creticum new inscriptions from crete
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new investigations of the inscriptions from crete are highly desirable and expected by historians and epigraphists of ancient greece the inscriptiones creticae icret vol iiv published by m guarducci between 1935 and 1950 lacks both of the fifth volume which should have been devoted to the inscriptions of cretan localities that are no longer identifiable and of a supplement on inscriptions discovered in the last 90 years many of the 15 geographical corpora included in the inscriptiones graecae ig the most important project on greek epigraphy such as those from attica or boeotia received an update after many decades because icret was independently published crete was not a priority for ig and an update dedicated to the cretan inscriptions never appeared therefore a new edition of all inscriptions from crete is strongly needed but it is beyond the possibilities of a single scholar requiring a very long time excluding the reedition of those inscriptions already collected in icret the proposed project is consistent with the time scale of a msca and would be beneficial to several disciplines specifically it aims at providingi a corpus of the cretan inscriptions not included in icret a broad scientific impact can be expected as this corpus will be in synergy with icret and with findings from other fields eg prosopographyii an open access digital database to make the result easily accessiblethis digital database will help in improving the most popular open access epigraphic publishing projects for greek inscriptions the openaccess database of epigraphic material will also be made palatable to a broader public accompanying the collected inscriptions with photos english translations commentary etc following the epigraphic tradition a book edition in latin will be printed addressed to a specialised audience gender social and environmental aspects although not central to the project are taken into account
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highly efficient heavy metalfree color conversion ink technology for microled applications
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qustomdot is the first and only company developing an allaround heavy metalfree quantum dot qd solution which is fully rohscompliant while combining high stability under high light flux with the excellent optical properties required by the microled applications this is an urgent demand from the display industry which cannot develop marketable microled displays without using an efficient qd color conversion technology qdcc free of heavy metalsour main target customers are the microled developersmanufacturers while the users are panel makers oems and the end user we are already collaborating with key players from all the layers of the value chain and we have 6 patent families 3 of them already grantedour unique capacity as key enablers of the microled technology will position us as the reference on qdcc for the nextgeneration display technology our vision is to become a world leader in the qd quantum dot market addressing a 20 of the market share by 2030
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hoverflies as a new class of managed pollinators for better quantitative and qualitative yields of vegetable fruit and seed crops
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polyfly produces and commercializes alternative natural pollination solutions for seed production and protected cropping based on a group of highly efficient pollinators syrphid flies also known as hoverflies flower flies our offering includes 2 new pollinators1 goldfly gf eristalinus aeneus is well adapted to hot and sunny conditions such as those encountered in the mediterranean basin 1440c2 queenfly qf eristalis tenax is better adapted to the cloudy and cooler conditions characterizing continental and oceanic climates of northern europe or spring and autumn seasons 1030cboth are common and widespread species e tenax is considered cosmopolitan and they are excellent pollinators as they exhibit a strong floral foraging behaviour similar to the one of bees like them they continuously visit flowers to feed on pollen and nectar sources of proteins and carbohydrates necessary for their development and survival
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trustworthy ai tools for personalized oncology
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modern machine learning algorithms have the potential to accelerate personalized medicine in a fast pace to date first tasks in medicine are being addressed with machine learning algorithms that surpass humans in terms of accuracy and speed including diagnosis outcome prediction and treatment recommendation however for a widespread adoption in clinical practice a good performance in terms of speed and accuracy is not sufficient practitioners also need to be able to trust a models prediction in all stages of its life cyclei will facilitate an efficient interaction of clinicians with ai models by developing trustworthy ai tools for personalized oncology first i will develop trustworthy ai tools and algorithms for diagnosis and stratification of cancer patients second i will establish a framework for reliable and transparent modelling of personalized outcomes and therapy decisions in oncologytaipo will result in novel algorithms and software tools for quantifying and improving the trustworthiness of ai models that i will apply to three clinical applications i trustworthy aibased skin lesion classification based on dermoscopic images ii stratification and personalized outcome modelling for patients with acute myeloid leukaemia aml based on omics data and iv therapy recommendation for metastatic breast cancer patients based on electronic health recordstaipo will increase the throughput of trustworthy diagnoses of skin lesions and pave the way for lowcost access to diagnostic care it will empower clinicians to make personalized and reliable therapy decisions which we will demonstrate at the example of aml and metastatic breast cancer our novel algorithms to evaluate and improve the reliability of ai models are a crucial contribution to close the gap between insilico aibench and bedside and will further push the field of trustworthy machine learning with many applications of ai in medicine
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improving bioproduction through dynamic regulation circuits
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biological production of chemicals and materials is a renewable and economically viable alternative to the current chemical processes easing the transition towards a biologybased circular economy the current biomanufacturing industry faces a scalability problem frequently producer strains created in the laboratory do not respond well to industrial conditions eg large fermentation volumes accumulation of toxic intermediates media acidification etc the goal of biocircus is to address the issue caused by the lack of robustness of the engineered microbial strains biocircus is based on three main research pillars 1 the construction of biosensor and dynamic regulation circuits that measure and control the production of the target molecule 2 the use of machine learning predictive models and automation to improve these circuits and 3 validating the designed strains in preindustrial conditions closer than standard molecular biology laboratory procedures to realworld bioproduction operations naringenin a key molecule of the flavonoid family will be used in as proofofprinciple molecule e coli will be used as model organism the design and construction of biosensors and dynamic regulation circuits controlling naringenin production is expected to support the development of methodologies and tools suitable for any other detectable metabolite biocircus will produce academic and industrial impacts that will boost the bioproduction field by enabling a shorter strain timetomarket for a wide variety of adaptive and scalable microbial bioproducer strains
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development of a marketable adjuvant candidate for vaccine applications
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adjuvaccine seeks to leverage a breakthrough made in the erc2016stg716878 project to validate a synthetic technological platform for the scalable production of identified optimised saponin adjuvants for improved costeffective vaccines we have developed in the laboratory potent safe stable and streamlined adjuvant leads that surpass the qs21 natural product adjuvant leading to patent applications and the interest of pharma in this poc project we aim to exploit our synthetic saponin technology to produce adjuvantvaccine candidates at scale that outperform existing products more costeffectively lowering the risk profile of the commercialisation potential while also achieving valorisation outcomes for market entry the goal is to demonstrate the scalability of our innovative adjuvant technology and select an optimal adjuvant candidate in advanced preclinical settings for entering the vaccine market via spinoff formation following proper ipr strategy implementation and attraction of key investorspartnersthe breakthrough innovation potential of adjuvaccine lies in the exploitation of this adjuvant platform for largescale production and selection of the best candidate lead for application in vaccines against various diseases improving the available vaccine solutions the high purity and excellent chemical control of our synthetic technology versus the heterogeneous natural product adjuvants as well as its streamlined scalable nature and lowcost profile are unique attributes of our platform that will be valorised herein making it a potentially superior alternative to existing vaccine models with less structural definition and costlier timelines the main objectives are 1 demonstrate our synthetic technology platform for the gramscale production and selection of a candidate adjuvant lead and 2 implement valorisation opportunities and verify the potential of spinoff creation by establishing an optimal ipr and publicprivate funding roadmap plan
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amazing largescale trials and pilots for verticals in 6g
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amazing6g proposes a novel set of 14 use cases in the domains of healthcare public safety energy and transport including rail which will be showcased in largescale trials and pilots across europe innovative technology enablers are planned to be developed and tested in the areas of communications computeasaservice applications and ai iot and localization security aspects will be taken into consideration in the development of solutions framed in this context the significance of largescale trials in b5g6g networks lies not only in their ability to validate the technical capabilities of the technology but also in their capacity to unveil new use cases and applications that were previously inconceivable as we move towards a world where the internet of things iot augmented reality and artificial intelligence play central roles in our daily lives these trials provide a unique opportunity to explore the potential of b5g6g in fostering innovative solutions across various sectors from healthcare and transportation to utilities and publicenvironment safety through largescale trials stakeholders can gain valuable insights into the transformative power of b5g6g networks and strategically position themselves to harness the full spectrum of opportunities that this cuttingedge technology offers
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utilization of private land for mainstreaming naturebased solution in the systemic transformation towards a climateresilient europe
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land4climate aims to increase the resilience of landscapes and urban settlements in the continental biogeographical area and beyond by nudging the implementation of naturebased solutions nbs which are at largescale still in its infancy however there are three reasons for the tardy uptake of nbs in practice 1 nbs need more land than grey infrastructure 2 approaches to nbs hitherto often focus on public land 3 private land however bears huge potential for climate resilience both as a supplier in terms of ecosystem service provision and a recipient of benefits of nbs in terms of climate risk reduction land4climate addresses these implementation gapsclimate resilience needs land land4climate aims to get access to private land for the implementation of nbs not by buying land but through the development of innovative governance schemes and business models such as land readjustments schemes strategic land leases and easements the main objective of land4climate is to codesign and validate nbs on private land through implementation and upscaling with innovative strategies of land policy for a transformative climateresilient future in areas with multiple risks especially coupled extreme hydrometeorological events such as floods droughts and urban heatland4climate will operationalize this objective in six frontrunner cases in austria czechia germany italy romania and slovakia by identifying cause and effect relations of climate risks and nbs to allocate nbs effectively and efficientlydeveloping governance and business models to implement legitimate and just strategies of land policy for nbs on private land enabling successful replication and upscaling by involving seven replicant regions in the aforementioned countries land4climate becomes able to replicate foster and inspire new synergies between nbs beneficiaries and landowners on a wider scale and contribute to the eus mission for adaptation to climate change
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ondas de peniche
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the untapped potential of wave energy emerges as a promising horizon projected to reach up to 1800 twh per year in europe however full operational conditions of a wave energy farm are required to improve market confidence and increase the bankability and insurability of wave energy commercial projectsin this context ondep aims at setting up a 2mw farm composed of 4 waveroller units connected to the grid in peniche portugal this will leverage 10 years of experience at this site including two years of fullscale demonstration of the patented and certified waveroller unit 20192021 over five years and a half ondep aims at emulating the needs and technical challenges of future extra largescale wave farms while establishing a complete endtoend european supply chain for gwscale deployment in europe it also includes the first comprehensive environmental analysis spanning several decades for wave energy production ondep is a pathway to scale up wave energy farms in the short term and by 2030 the project expects to unlock 11 farms in 8 countries across 4 continents with a cumulative 83 mw capacity mous and support letters already signed and a gwp 25 gco2eqkwh beyond 2035 the expected lcoe 100mwh will pave the way towards a sustainable blue economy creating up to 500000 jobs in europeto achieve its ambitious goals ondep involves 9 countries and 14 leading organisations covering the whole endtoend value chain of the wave energy sector
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on the use of internet of senses for the cultural heritage
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creative industries encompass a diverse array of sectors including arts craftsmanship media design advertising software and more current research trends often focus on addressing various challenges and opportunities within these industries one prevalent area of study involves examining the impact of emerging technologies on creative processes particularly in terms of technological advancements and innovation artificial intelligence ai generative ai internet of senses and digital twins dts are key technologies frequently explored in this context by leveraging these technologies within a virtual immersive world there is potential to create an innovative platform that opens up opportunities for novel services in the cultural and creative industries ccis domain ellie aims to support ccis in enhancing their portfolios by providing a universal platform that integrates multiple highimpact technologies like the above and immersive worlds this platform seeks to facilitate the creation of new user experiences simplify the development of creative products and better understand user needs ellies overarching objective is to offer a comprehensive solution that aids in the delivery of advanced services and expedites the production of new products this initiative empowers stakeholders to streamline the workflow of service and product creation through the combination of the above technologies ellie supports innovative and automated processes ultimately providing end users with highquality experiences
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regeneration of neighbourhoods through placebased approaches
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ginnger will ease the regeneration of neighbourhoods and built environments through the implementation of cocreation processes in heterogeneous stakeholders structures this will facilitate the planification and implementation of actions in local environments leading to a reduction of social environmental technological and economic risks thus to deliver healthy affordable and sustainable built environments in eu the project will create positive social impact in neighbourhoods by stablishing and validating the ginnger cocreation methodology aimed at supporting decisionmaking procedures for regeneration actions the cocreation methodology will rely on ssh innovations for social progress and the enhancement of public policies the project will put special emphasis on the validation of the cocreation methodology in 6 pilots p1 langreo es p2 plovdiv bg p3 massagno in ch p4 murcia es p5 orte it and p6 paris fr within these pilots the cocreation methodology will support the implementation of 21 regeneration actions moreover ginnger will setup a local figure called the green neighbourhood facilitator which will ensure that voices across pilots are heard and will lead the capacity buildings actions at local level to complement the implementation of the regeneration actions from a technical perspective ginnger will develop and validate a digital toolkit to support the planification implementation and operation of the regeneration actions the digital toolkit will be composed by a total of 13 digital solutions grouped into four blocks dealing with energy renovation resources and mobilityas a result ginnger will set longterm strategies for the planification and implementation of cooperative models for neighbourhood regeneration facilitated by the generation of 14 key exploitable results during the project the implementation of such an ambitious project requires of a consortium of 24 partners from 8 ec member states
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barents sea arctic cenozoic evolution and paleogeographical reconstructions
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this project barents sea arctic cenozoic evolution and paleogeographical reconstructions bravo aims to reconstruct the barents sea gateway since the cenozoic the last 66 myr to do so bravos objectives are to 1 reveal the effect of sediment loadingunloading lithospheric strength and surfacemantle processes on shaping the cenozoic paleobathymetrytopography of barents sea to 2 constrain the timing of the formation of the bsg to 3 identify the interplay between climate dynamics and tectonics in erosion and deposition of sediments in the paleobarents sea and 4 compare the development of the bsg and fram strait as well as the regional to global consequences of the arcticatlantic shallow water connection bravo will achieve these objectives by numerical modelling inc finite element and volumetric methods using opensource platforms of pygplates pybadlands and highresolution 2d3d seismic well gravity and magnetic data analyses bravos results will be selfconsistent 4d earth models space and time of paleobathymetrytopography of barents sea gateway and corresponding sedimentary pathways and accumulation bravos ambition is to provide the most reliable paleobathymetrictopographic reconstruction of the barents sea gateway for the cenozoic bravo will quantify the role of barents sea gateway in exchanging atlanticarctic water highlight the significance of erosiondeposition of sediments in shaping the gateway and form the basis for updated global oceanographic and climatic simulations bravos pioneering model of the complete cenozoic sourcetosink analysis for the regional barents sea will be a breakthrough for arctic seabed characterization for offshore wind turbines and mapping slope failure geohazards
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photonic quantum technologies with strainfree artificial atoms
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photons are an excellent platform to explore fundamental quantum properties without disturbance from the environment they are also advantageous for applied topics such as quantum communication and simulation the prerequisite for exploiting photons in quantum science is producing and manipulating highquality streams of entangled photons in a scalable setting yet the progress on this front has been slow primarily due to shortcomings in material properties so far only small states involving three photons have been demonstrated and the quest of generating twodimensional entanglement is untouched in this project i will address the scalability problem employing an emerging class of artificial atoms named gallium arsenide quantum dots gaas qds contrary to standard qds gaas qds are free from mechanical strain as a result gaas qds have lower noise and different gaas qds have similar optical properties these are critical requirements for a scalable platform we will use photonic nanostructures to flexibly interface gaas qds on a photonic chip such a scalable platform will be an invaluable contribution to photonic quantum technologies as an immediate outcome we will use this platform to deliver three novel goals1 highly entangled states of photons with twodimensional connectivity2 first experimental studies on the interaction between photons in a strongly nonlinear medium3 pave the way towards quantum memories based on the collective states of nuclei in a qdthese achievements will be enabling contributions to quantum technologies twodimensional clusters of entangled photons are indispensable resources with immediate applications in quantum communication and will open new prospects for photonic quantum simulation additionally studying the interaction between photons in a strongly nonlinear medium will enable us to build numberresolving photon detectors and in the longer term may enable emulating manybody quantum systems on our platform
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skill partnerships for sustainable and just migration patterns
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this project aims to develop systemic analysis of skills shortages in the 5 eu countries france germany italy poland lithuania and 6 non eu countries turkiye uk norway noth macedonia ukraine ethiopia in the context of the global workforce migration by providing researchbased evidence on the nature and development of skill shortages as well as on the potential of different skills partnerships to tackle these shortages in the countries of origin and destination of migrants there are four main objectives of research serving as a basis for the corresponding workpackages which contain different sets of research questions and activities1 designing of the shortage model for recruitment of skilled workers in the countries of destination 1st group transition countries 2nd group by referring to the agency of existing skill partnerships in these countries 2 evaluation of the labour market in analysing matching needs and shortages of skilled workforce in the countries of origin compared to the countries of destination and transition countries 3 surveying skilled migrant workers in the countries of destination and origin returned migrants this survey seeks to provide the perspective of migrants to the above discussed questions of research 4 analysis of conditions which influence positively or negatively local development processes visvis foreign upskilling and recruitment in the destination countries as well as the conditions which lead to domestic institutions of the origin countries to capitalize on the positive effects of migration for skill development of their population 5 preparing a toolkit for implementation and development fo skill partnerships between the countries of origin and destination in order to enable and facilitate sustainable and fair investments in skills and dealing with the challenges of skill shortages and migration by preventing skill losses and brain drain
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glycans as master triggers of health to intestinal inflammation transition
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chronic inflammation underlies several diseases in crohns disease cd there is mounting evidence of a preclinical phase characterized by immunological changes that precede symptoms here we propose a thorough and innovative approach to better understand the healthtochronic inflammation transition occurring in patients with cd that will be translated in improved disease prediction and prevention we will address how changes in glycosylation of the gut mucosa act as a primary event that dysregulates not only local mechanisms imposing maladapted hostmicrobiome interactions but also systemic mechanisms promoting antimicrobial antibodies production involving the novel concept of glycan mimicry as an early trigger of the health to inflammation transition glycantrigger capitalizing on our recent findings showing that changes in the expression of complex branched nglycans at gut mucosa regulate inflammatory bowel disease immunopathogenesis we here hypothesize that changes in gut glycocalyx impose early perturbations in hostmicrobiome interactions leading to the exposure of altered glyconeoantigens both by pathogens and host epithelial cells which trigger the activation of innate immune response moreover following our recent discovery that changes in glycosylation can be detected in serum years before cd diagnosis and are correlated with increased levels of pathogenic antimicrobial antibodies asca we will here pursue the hypothesis that changes in mucosa glycans constitute a major source for the development of antiglycan antibodies asca associated with healthtoinflammation transition the longterm goal of this proposal is to unlock through an integrative approach a new checkpoint that regulates the transition to chronic inflammation our proposal will lead to breakthrough concepts in the health to chronic inflammation transition and to novel predictive tools translated in novel glycointervention strategies for disease prevention
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trapping and killing glioblastoma
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glioblastoma multiformegb is an aggressive brain cancer associated with a 2 5year survival rate and 250000 new diagnoses globallygold standard treatment includes surgical resection and radiotherapy coupled with temozolomidetmz chemotherapy that promote cancer cell deathresistance to tmz and radiotherapy develops rapidly due to dna repair mechanisms indicating that targeted disruption of them can potentiate these therapies trapkill combines cancer mechanobiology microfabrication and biomaterials engineering to develop a pioneering therapeutic trifunctionalised hydrogelphysically modified to present 3d microchannelsand chemically functionalised with gb chemoattractant cxcl12 and tmzthese promote durotaxischemotaxismediated gb cell infiltrationconstraining cells into elongated morphologiesstressing the nucleusdisrupting dna repair mechanismsand rendering cells susceptible to therapies i have shown that 3d patterned hydrogels promote gb gl261 cell infiltrationforcing cells to adopt a filamentous conformation and subjecting the cell nuclei to significant sheartensioncompressive forcesfollowing microchannel sequesteringpreliminary data indicate that cells upregulate stressrelated signalling processes and lose the protective effects of cell agglomerationit is envisaged that trapkill glioblastoma therapy will significantly enhance the efficacy of gold standard chemoradiotherapy approaches trapkill objectives includea chemoattractanttmz functionalised and micropatterned hydrogel to create trapkill therapy analysis of microchannel dimensions on gb cell morphologynuclear stress and cell sensitivity to tmzgamma radiation in vitroassess transcriptome changes in mechanically stressed gb cells and in dna repair gene transcriptionpreclinical resectionradiation murine gb model assessmenttrapkill will create a transformative gb treatmentwith a combined approach to significantly revolutionise existingnextgeneration gb therapies
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research infrastructure access in nanoscience nanotechnology
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research in the fields of nanoscience and nanotechnology is vital for sustainability globally advancement in nanoscience and nanotechnology cannot be achieved without using research infrastructures ri riana encompasses 7 european networks of toplevel ris to cover the most advanced techniques relevant for synthesis nanofabrication processing characterization analytics as well as simulation capacity highly customised and efficient access to 69 infrastructures is coordinated via a singleentry point and enabled through comprehensive science and innovation service by senior scientists experts for the transfer of technology from academia to industry and highly trained junior scientists the junior scientist boost ri experience to an entirely new level they provide customised science service supporting users from initial ideas to handson experiments data analysis and dissemination of results to generate the greatest impact from access to worldclass ri this core of riana is aligned to attract experienced and new users from academia or industry making their promising ideas a success and push them to higher trl riana is flexible to upcoming emergent scientific topics and needs together with stakeholders from the nanocommunity riana implements the opportunity to offer flexible access to additional infrastructures in and even outside of europe beyond the current consortium and to direct the science service towards evolving user needs via additional specialised junior scientists based on the four years of experience the riana consortium will develop a roadmap for the future of the nanoscience and nanotechnology at european ris
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high dimensional probability and combinatorics
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this project concerns three related topics concerning high dimensional probability and combinatorics the first part concerns fundamental questions concerning random matrices these include the problem of finding sharp bounds on the singularity probabilities for discrete random matrices and determining the limiting spectral distributions of sparse matrix models the second major goal of this project is to make progress on the hypergraph ramsey numbers and the multicolour ramsey numbers these are two absolutely central objects in combinatorics which remain mysterious in many respects despite many years of intense activity finally i propose to study the chowla cosine problem this is an old problem in the area of harmonic and fourier analysis which the pi has recently been studying through a probabilistic lens
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superconducting and ferroelectric twodimensional electron gases 2degs at oxide interfaces
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in the project surfer we will demonstrate the coexistence of antagonistic properties namely superconductivity sc and ferroelectricity fe and the enhancement of superconducting transition temperature tc through coupling with fe in oxide twodimensional electron gases 2degs so far this coupling has almost only been observed in bulk oxides and in thin films of doped srtio3 sto where no ferroelectric switching is possible due to the threedimensional distribution of carriers the origin of sc and enhanced tc due to coupling between fe and sc is still not clarified which might be because only one material sto system has been studied in surfer we aim to realize ferroelectric and superconducting oxide 2degs with enhanced superconducting properties that are also switchable with fe present in these systems with this aim we will explore three new oxide 2deg systems that have not been studied so far which will be fabricated based on different ferroelectric materials 1 sto thin films 2 batio3 and 3 niobium nbsubstituted ktao3 by growing on top a thin metal or oxide overlayer in addition to the experimental realization of oxide 2degs hosting such interesting properties this project will also help us to gain a clear understanding about the origin of sc and enhanced tc due to fe and sc coupling in oxides which is a longstanding question by investigating the properties of these material systems in detail
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defining clinical and molecular phenotypes of multidrug resistance in difficult to treat rheumatoid arthritis
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rheumatoid arthritis ra is the most common chronic inflammatory joint disease with a prevalence of about 1 of the adult population 22m patients worldwide and 7m in eu and estimated to be responsible for 10000 disability adjusted life years dalys costing eu society 55b annually despite aggressive therapy about a third of patients have to give up work within 5 years of disease onset mainly due to lack of response to multiple disease modifying antirheumatic drugs dmards multidrug resistance mdr thus the main objective of this proposal is to define the clinical and molecular phenotypes leading to mdr in ra patients to prevent when possible or when not possible optimise the management of these patients mdrra is highly relevant to the program as these patients are often disabled unable to work and paying a high personal and societal burden moreover mdrra is underresearched and the underlying pathobiological mechanisms for resistance remain unknown while as we have no predictors of therapeutic response to any of currently available drugs inevitably treatment is based on trialanderror mdrra has the ambition of transforming care for these patients and deliver significant advances beyond the stateoftheart methodologies as for the first time molecular pathology will be integrated into clinical psychosocial pain perception and imaging profiling in existing clinical cohorts to develop truly holistic predictive models for future clinical use icarera the transformative potential of icarera will be tested in a prospective randomised trial in comparison with routine standard of care while its future implementation potential will be assessed through an early economic modelling finally a strong management and dissemination strategy will facilitate further advancing science in the field beyond the duration of the project and future adoption by patients specialist professional bodies policy makers and regulatory authorities
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prenormative research on integrity assessment protocols of gas pipes repurposed to hydrogen and mitigation guidelines
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transporting natural gas through pipelines has been shown to be safe and efficient for decades however decarbonizing the european industry and reducing carbon emissions will require a significant portion of the existing pipeline infrastructure to be used for transporting gaseous hydrogen under high pressure across the continent from production sites to end users the pipelines originally designed for natural gas are not considered h2ready and transmission system operators must demonstrate their compatibility with hydrogen the existing standards such as asme b3112 are often viewed as overly conservative and not conducive to the development of pure hydrogen networkspilgrhym is an ambitious rd project that seeks to develop a prenormative framework to support the development of a european standard the project aims to conduct a comprehensive testing program on smallscale laboratory specimens focusing on 8 base materials 2 welds and 2 heataffected zones that are representative of the eu gas grids these specimens will be selected after a thorough review by tsos to address safety concerns lack of regulations codes and standards as well as research gaps related to the compatibility of current pipelines with hydrogen pilgrhyms ultimate goal is to provide quantified data on more than 70 of the eu grid and refine existing norms codes and standards by reducing overconservatism and ensuring the safety and reliability of flaw assessment methodologiesthe results of pilgrhym will serve as the baseline for a harmonized european solution this project represents a significant step forward in the development of a comprehensive european standard for transporting hydrogen through pipelines and will be instrumental in the successful decarbonization of the european industry and reducing carbon emissions
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root phenotyping integrated educational doctoral network
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a deeper understanding of the interactions between soils and plants especially at the root zone where they take up waterand nutrients may support sustainable intensification of agricultural production research is indicating that a greaterunderstanding of roots and soil functions may lead to increases in crop yields reductions in greenhouse gas emissions fromsoils enhanced productivity in grasslands and reductions in fertilizer requirements to land however data gaps remain in ourunderstanding of how plant roots interact with their environment from a physiological and phenotypic perspective plantphenotyping has been described as the bottleneck to food security yet the real bottleneck to plant phenotyping is thought tobe image analysis and processing the challenge of ensuring food security provides the impetus for rooted rootphenotyping integrated educational doctoral network rooted will apply deep learning and artificialintelligence to speed up data generation in root phenotyping agriculture is increasingly using digital technologies butcurrently 44 of the european workforce do not have these basic skills this is a severe skills gap that europe needs toclose urgently to avoid economic downturn rooted will consolidate the complimentary expertise of an internationalinterdisciplinary multisectoral team to train a new generation of creative resilient adaptive multiskilled scientists capable ofinnovating the fields of plant and soil sciences to actively contribute to the goal of doubling food production in a sustainablemanner by 2050 soil health and food is one of the 5 mission areas for horizon europe and the findings from rootedwould be directly applicable to the eus green deal and a soil deal for europe rooted graduates will have a level of scientific communication and digital skills mastery that enables them to move straight into employment in agrifood businesses seed and breedingcompanies advisory and scientific roles
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a gamechanging solarthermochemical heat storage and intensification technology for the process heat sector
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this project proposes a gamechanging integrated technology of solar collectors and thermochemical energy storage tces systems this solution is primarily proposed to bring sustainability to the process heating sector which has been so far very challenging to decarbonize due to a lack of costeffective and reliable solutions besides this main feature the proposed technology has some distinguishing attributes that make it groundbreaking scientifically and very competitive technically these are 1 solving the technical challenges of tces systems namely material agglomeration over time and nonuniform heat distribution throughout the material within the reactor 2 integration of the solar collectors field and the tces system leading to lowered capital and maintenance costs and increased overall efficiency and 3 significant temperature lifting of the stored solar heat during the hydration phase of the thermochemical material enabling the system for process heating at much higher temperatures which are otherwise not possible by a solar energy system with main hypothesis that the uniform flow of reactive material can effectively be controlled and helpful for its agglomeration and nonuniform heat distribution prevention soltec aims at laying the first stone of research on this technology and pushing the edges of the stateoftheart through a developing the theoretical principles of solar heat capturingstoringintensification process b developing the optimal and compatible design of the collectors for this and c technoeconomic and environmental evaluation of the technology the project will develop the fundamental theories and methods to design optimize and test this innovatively operating solar system
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highly redoxactive atomic centers in electrode materials for rechargeable batteries
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lithiumion batteries are the stateoftheart electrochemical energy storage technology sodiumion batteries are about to become commercial and potassiumion batteries are attracting rapidly increasing interest all these alkaliion battery aib technologies especially the already or soontobe commercialized battery chemistries have one common characteristic making them so successful the use of insertiontype electrode materials these materials provide sufficient space in their crystal structure for the alkali ions to be reversibly inserted without causing substantial irreversible rearrangement however the fact that the ions can only occupy specific sites in the host lattice intrinsically limits the amount of ions that can be reversibly insertedthe aim of this project is the development of a new family of electrode materials for aibs which is characterized by an innovative storage mechanism this mechanism combines the benefits of a stable insertiontype host structure with an extended redox activity and additional available space for the alkaliion charge carriers resulting from the introduction of carefully selected atomic redox centres arcs based on own preliminary results and new yet to be developed suitable host matrices and arcs and their comprehensive investigation by highly complementary exin situ and operando characterization techniques to gain an indepth understanding of this new mechanism we will develop specific guidelines and design criteria for the realization of such novel materials these criteria and guidelines will be effectively evaluated by designing new materials which benefit of this new charge storage mechanism and thus enable longterm stable insertiontype aibs with enhanced energy and power densities moreover the results obtained will allow for an improved understanding of the redox behaviour of the highly active arcs at the atomic level a field of research that has been limited to theoretical studies so far
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deep brain neuromodulation using temporal interference magnetic stimulation
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five out of ten diseases leading to long termdisability are related to the brain including stroke depression or dementia despite tremendous progress in neurotechnology there is still no effective treatment option available for many brainrelated disorders a very promising approach to treat brain disorders uses transcranial electric or magnetic stimulation testms to directly influence brain activity related to specific symptoms however these methods are limited in their spatial resolution specificity and ability to reach deep brain areas the aim of the proposed project is to develop a technical and experimental proofofconcept for a new noninvasive tool that allows for millimeter and millisecondprecise modulation of neural activity in superficial and deep areas of the human brain capitalizing on temporal interference effects the device will apply high carrier frequency magnetic fields through a pair of coils by modulating their relative phase the combined fields will induce a locally amplitudemodulated electric field in the brain as neural tissue is insensitive to unmodulated highfrequency fields 1khz but responds to lowfrequency amplitudemodulated fields only brain regions will be stimulated where the combined field is amplitudemodulated building on the resulting versatility of stimulation frequencies and waveforms we aim at providing proof for celltype specificity of such temporal interference magnetic stimulation tims moreover we aim at providing proof for the feasibility of targeting neural activity at millisecondtomillisecond precision availability of such device offering high spatial resolution depth selectivity steerability as well as closedloopcompatibility and celltype specificity would mark a major breakthrough for clinical neuroscience together with two partners from industry and a partner for technology transfer we strive for fast translation of expected research results into innovative products
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bauhaus of the seas sails
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the vision of the boss project is to demonstrate and archive solutions for climate neutrality with a particular focus on coastal cities as an interface to healthy seas ocean and water bodies envisioning a new triangle of sustainability inclusion and design focused on the most important global natural space the bos will offer opportunities to engage with communities for an environmentally sustainable socially fair and aesthetically appealing transition seven lighthouse demonstrators located in four different regions and aquatic ecosystems in portugal estuary italy lagoon and gulf swedengermany strait north sea river and the netherlandsbelgium delta will showcase the transformational and uptake impact at the eu level serving as lighthouse pilots for the implementation of horizon europe mission objectives and showcase innovative solutions the seven pilots will all provide tangible examples of missionoriented approaches that are impactful measurable and targeted the action plan includes the deployment of drops in all pilots designed to generate ripple effects at the local demonstrator level but then also at the cityregion levels demonstrating effects of scale and at a broader level demonstrating the replication the boss therefore introduces an ecocentric narrative both cosmopolitan and rooted in naturebased solutions plural and testimonial proposing to apply a design approach to complex sociotechnicalecological and morethananthropocentric problems an agenda that moves from fixing to caring from growth to nurture from certainty to contingency will enable designers architects and engineers to think about assemblages instead of systems and change the outcome from extinction to precarious flourishing the design of these interactions generates the emergence of new aesthetics and most decisively a critical awareness of the history contemporary and future designing beyond humans as a way to sustain our future
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enzymatic piezoelectric composites to regenerate redoxcofactors driven by mechanical sources
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the costefficient production of sustainably derived biochemicals and biofuels is a critical goal of modern biotechnology redoxbiosynthetic pathways are fundamental in chemical manufacturing for establishing a biobased economy the sustainable regeneration and recycling of redox cofactors is a prerequisite for the viable industrial exploitation of many described redoxbiosynthetic pathways these boundaries hamper the employment of cofactordependent biotransformations at largescale production processes to overcome these limitations the main objective of this project piezozymes pushes the forefront of technology pursuing novel biotechnological tools aimed at the efficient regeneration of redox cofactors powered by mechanical sources such progress will bring several advantages over the current cofactorregeneration systems where the traditionally employed biochemical electrochemical and photonic sources will be replaced by mechanical ones the resulting technology of this project will have valuable social impact paving new pathways for the costefficient exploitation of cofactordependent enzymes as economically suitable biocatalysts in a plethora of industrial catalytic biotransformations
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demonstration of digital twins for a green steel value chain
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in context of the transition to lowcarbon green and sustainable steel production in europe disruptive technologies to reduce the environmental footprint as close to zero as possible seamless digitalisation of production processes and skilled people to codesign and understand the transformation process are necessary digrees will address these needs by implementing an integrated digitalisation approach across the steel value chain enabling better use of process data collected and ensuring the involvement of human experience for easier industrial integration the aim of digrees is to develop a userfriendly digital platform for networked production based on novel and soft sensors and related approaches and models to support efficient feedstock verification and realtime control of electric arc furnace crude steel production increasing process yield while improving the quality of intermediate and final steel products in this context the potential of artificial intelligence techniques will be fully exploited to support the optimal use of industrial data and different scenarios specific to each use case will be modelled the digital platform will be implemented and verified in industrial process lines of the three use cases scrapsecondary raw material verification optimisation of the electric arc furnace processes and optimisation of the levelling of steel sheets digrees aims to improve the quality of crude steel and finished products optimize scrap usage and improve energy efficiency in the steel production process digrees has the potential to save up to 800 million in costs annually and reduce co2 emissions from the steelmaking industry by up to 6 million tonnes per year
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riskbased approach for the protection of public spaces in european cities
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over the past decades europe has experienced several terrorist attacks proving that this threat is still real and serious while perpetrators are finding new methods to penetrate current security measures although grave attacks have so far been rather infrequent it is still a reality that eu citizens may be suddenly caught up in a terrorist incident while at the stadium shopping in a mall commuting visiting a cultural venue or in any other public space besides more terrorist attacks are associated with lower levels of life satisfaction and happiness among the eu population one in five people in the eu are indeed very worried about a terrorist attack in the next 12 months terrorist attacks also lower eu citizens trust in fellow citizens national political legal and police institutionssafecities aims to support excellence in the protection of public spaces by delivering and demonstrating a security and vulnerability assessment framework empowered by a decisionsupport platform for its implementation in 4 usecases across 5 eu countries this will allow for simulation of complex scenarios crowd behaviour and attacks in any space within a realistic virtual 3d environment enabling endusers to perform comprehensive and dynamic risk and vulnerability assessments of the site investigated to identify potential vulnerabilities against a wide number of threats and support the full engagement and cooperation of public and private actors including citizens into the elaboration of strategies to make public spaces secure while preserving their open naturethe consortium brings together 17 partners from 9 countries italy cyprus netherlands greece poland uk belgium finland slovenia to effectively carry out the 32 months project the project team includes local and regional authorities police authorities first responders organizations rtos and academia cso security industry cluster association and hightech smes specialised in security
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the impact of human aged bone marrow niche on human hematopoietic stem cell function
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in humans aging of the hematopoietic system is associated with anaemia impaired immune responses and increased frequency of myeloid malignancies the hematopoietic system is maintained by hematopoietic stem cells hscs hscs reside in the bone marrow bm within specialized niches where they selfrenew and differentiate to produce all blood and immune cells in the clinical setting of bm transplantation hscs from older donors result in a reduced transplantation success with a worse level of engraftment and higher overall mortality this demonstrates that there is a reduction in the function of aged human hscs hhscs causes of this impaired hhsc function with age still remain unclear therefore it is of great importance to uncover and subsequently target factors that contribute to hhsc aging in order to attenuate impaired haematopoiesis in the elderly due to the lack of meaningful human bm hbm niche models in the aging field the current understanding of how extrinsic changes stemming from the aged hbm niche contribute to the aging of hhsc is far less advanced compared to the knowledge of the contribution of cellintrinsic changes thus this proposal focuses on providing a significant understanding of ageassociated changes within the hbm niche and their contribution to the aging of hhscs using an agingcentred hbm niche model transplantation of young bm hhscs into this advanced niche model revealed that an aged hbm niche confers aging on young hhscs to this end the target of the proposal is to address the following questionsihow does aging affect the cellular and molecular composition of the hbm nicheiito which extent does an aged hbm niche affect aging of hhscsiiiwhat are the underlying mechanisms that confer an agelike function on hhscsmanage hsc addresses both technological and conceptual challenges in studying the role of the hbm niche in regulating hhsc function in the context of normal hematopoiesis and aging
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integrative profiling and engineering of clonal cancer cell behaviours from the tissue level down to the molecular scale
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clonal evolution in tumours the process by which cancer cells expand diversify and are selected is a major determinant of tumour growth and response to therapy how the coexistence of diverse cancer cell clones shape tumour development is a fundamental question that remains open in part because of limitations on existing experimental platforms and analytical frameworks our expertise inferring multicellular behaviours within tissue microenvironments together with recent advances in imaging assay automation and cell engineering timely place us in an excellent position to profile and engineer clonal interactions within tumours from the tissue level down to the molecular scale which enables targeting this important question with unprecedented throughput and spatial resolution in spaceclones we aim to 1 characterize clonal interactions in genetically engineered tumours at sub100 nm resolution 2 characterize clonal signatures under metabolically defined environmental conditions and 3 examine the cell state of engineered clonal spatial patterns to overcome a variety of challenges to understanding molecular and cellular mechanisms of clonal behaviours in tumours i have designed a groundbreaking approach that combines highlymultiplexed imaging in vitro and in vivo tumour models cell engineering superresolution microscopy combinatorial lowvolume liquid handling and algorithms for deconstruction of spatial patterns altogether spaceclones will exemplify how to imply causality on the emergence of clonal spatial patterns in tumours having farreaching implications for the study of any other multicellular system ultimately a deeper understanding of clonal evolution will contribute in the design of more effective cancer therapies and tools to predict clinical outcomes
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chiral separation of molecules enabled by enantioselective optical forces in integrated nanophotonic circuits
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separating enantiomers is crucial to produce bioactive molecules eg in earlyphase drug discovery chiralforce aims at a radically new strategy to separate enantiometers on chip using chiral optical forces at siliconbased integrated waveguides the present solution of chiral chromatography for this multibillion market is slow and cumbersome since it requires tailored chemistry for each chiral compound and relies on large and expensive separation columns instead chiralforce envisions cmlength optical circuits integrated with microfluidics for extremely quick tuneable and cheap enantiomeric separation the underlying mechanism relies on optical forces that are enantioselective due to interaction of spinproperties of the optical field with the chiral optical polarizability of matter these chiral optical forces can be tailored well beyond the possibilities of freespace chiral light through nanophotonic design of strongly confined modes flowing analyte in microfluidic channels along cmlength laserdriven will then result in enantioseparationthe approach to reach our main objectives relies on three main consortium strengths first we will design and synthesize chiral molecules and nanoparticles that will allow us to explore chiral forces regardless of how the chiral polarizability of matter is tuned by the size shape and inbuilt spectroscopic resonances next we will establish the general framework of chiral optical forces on nanoparticles and molecules in liquid environments leveraging our strength in nanophotonic theory design and experiment on chiralspinproperties of electromagnetic fields finally we will leverage our experience in nanotechnology to fabricate siliconbased photonic integrated circuits integrated with microfluidics to demonstrate enantiomer separation
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customised membranes for green and resilient industries
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increased energy and resource efficiency in industrial sectors is paramount to build a resilient and sustainable future in this context the cumeri project will develop and demonstrate at trl7 advanced and customised membrane separation systems in two key industries in the steel sector where h2 will be recovered and co2 captured in one comprehensive system and in the og industry where a twostep liquid filtration system will enable base oil and additives recovery from used lubricant oilto reach these goals cumeri gathers 16 partners 7 rtos and 9 companies including 4 smes and will elaborate in 36 months three impactful membrane technologies 1 enhanced biobased and recyclable polymer membranes for co2 permeation 2 stable and selective sicsicn membranes for h2 recovery for a better h2 valorisation in the steel sector 3 grafted porous ceramic membranes for waste oil purification and additives recovery by ultrafiltration and liquidliquid membrane contactors all membrane systems will unlock greater energy efficiency and decreased emissions in their respective sectors high separation performances together with increased chemical mechanical and thermal stability will be demonstrated moreover reusage and recycling of membranes will be validated beyond these demonstrations the project will generate novel insights on membrane separation including a variety of flexible solutions to help industry the scientific community and policy makers accelerate the rollout of separation technologies to maximise the impact of cumeri other promising separations will be screened and the transferability of results to other industries refinery pharmaceuticals etc will be ensuredthrough its activities cumeri will pave the way to decreased emissions in the industry to the greater valorisation of valuable chemicals and to more energyefficient processes promoting resilient and circular industrial value chains
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does exposure to artificial light at night impacts immunity and microbiome in natural populations of an amphibian
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the constant increase of urbanization and human activities worldwide is exposing animals and human to a multitude of stressful stimuli that disrupt physiological functions in organisms a major source of pollution nowadays that affect 99 of the european territory and thus almost every organism in europe is light pollution or alan artificial light at night recent studies suggest that the immune function could be strongly disrupted by exposure to alan but these results mostly comes from experimental studies conducted in laboratory conditions and thus not realistic of real conditions of exposure to the light pollution considering the current major biodiversity loss crisis especially in amphibian taxa it is crucial to know if the ability of wild organisms to mount appropriated immune respones and control infections is affected by this anthropic source of pollution within an ecoimmunological and one health framework this project has thus been designed to characterize for the first time and totally in natura the effects of alan on immunity microbiome composition and infectious phenotype of a common nocturnal vertebrate the common toad bufo bufo using 30 wild populations of common toads living on a natural gradient of exposure to alan in a french region this project will characterizei how exposure to alan impact toads immune phenotype using multiple measures to precisely characterize the different immune components that may be differently affected ii how exposure to alan impacts toads microbiome composition at the two main interfaces of skin and intestinal mucosa characterizing bacterial and eukaryotic communities iii if toads infectious phenotype is dependent of alan exposure immune responses and microbiome composition focussing on pathogens identified as a threat for amphibians in france
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coordination mechanism for cohorts and trials
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the overall goal of comect is to coordinate activities across europes strategic adaptive platform trials apts and cohort studies cs on infectious diseases ids with epidemic or pandemic potential by overseeing and facilitating dialogue sharing of good practices promoting collaboration and coordination across studies and providing updated information on initiatives and innovation in id clinical researchcomect will build on and strengthen existing networks and infrastructure these include eufunded coordination mechanisms and networks namely the trial coordination board tcb joint access advisory mechanism jaam the cohort coordination board ccb and the ecraid coordinating comittee comect will develop a visible welldefined coordination mechanism to highlight europes capacity and competence as an attractive base for clinical researchcomect will deliver1 an expanded combined european coordination mechanism that will work on harmonizing research initiatives exchange of good practices and stakeholder engagement across id clinical studies in outbreaks and during interepidemic phases2 a strengthened jaam to support coordination through independent scientific assessment of compoundsvaccines and recommendations for apts to evaluate the new compound in new or adapted platform trials3 the mapping of stakeholders and their respective activities relevant to apts and cs4 a harmonised approach crossstudy identification assessment and reuse of participantlevel data from european apts and cs5 coherent communications and stakeholder engagement across all activities6 a sustainability plan for the continuation of activities beyond the funding periodcomect will quickly adapt coordination efforts to a changing research landscape and to new id threats comect will operate in close collaboration with other emergency preparedness mechanisms such as hera ema glopidr and the european pandemic preparedness partnership
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european women and religious dissent the advent of modernity and the democratic public sphere
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at a time when fundamentalisms and populisms threaten basic human rights it is extremely important to investigate the roots of european values such as egalitarianism and democracy in order to contribute to popular and scholarly debates on these subjects in an informed way addressing the historical relationship between religion and ideas of modernity the euword project aims to provide a better understanding of laypersons contribution women and men to the development of the enlightenment when democratic concepts gradually emerged as basic rights it addresses particularly the history of a religious minority in seventeenthcentury europe the dutch collegiant movement and pursues a specific goal to reveal how the practice of enlightened concepts and the participation of women in freediscussion meetings cocreated the development of enlightened values the theory did not cause the practice both were mutually implicated in development to pursue this goal the euword project blends the methodologies of social history gender history history of ideas and political philosophy and has two objectives 1 an updated account of the collegiants practices the presence of women among their ranks and their european network regarding their meetings as interconfessional free associations that fostered the birth of an early public sphere 2 an examination of the interrelations between the collegiants practices and the concepts they advocated focusing on their debates on gender equality and womens right to free speech and revealing how these debates were related to similar ones throughout europe due to its originality and interdisciplinarity the euword project will have a major impact on several fields of study as well as on the general public indeed research outcomes will be disseminated through academic eg a digital map of the collegiants network and two scholarly articles and public eg a twitter account and blog entries activities
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innovative multifunctional retrofitting systems for heritage structures
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65 of the built cultural heritage is structurally deficient due to ageing lack of maintenance and exposure to natural and manmade hazards this figure is expected to increase given the effects of climate change structural retrofitting is vital for the preservation of our cultural heritage and the safeguarding of its social and economic value traditional repair systems have shown inadequate longterm performance with 20 of the repairs failing only after 5 years thus requiring everincreasing rehabilitation and maintenance costs this calls for more durable retrofitting solutions capable to guarantee structural performance and provide actionable information on their damage state before safety is jeopardisedaesthesis will leverage stateoftheart retrofitting systems for heritage structures using textiles embedded in inorganic matrices and transform them for the first time into smart systems that can feel the damage and repair themselves both textiles and matrices will be engineered through the inclusion of sustainable electrically conductive materials and industrial byproducts to achieve desired electromechanical properties and stimulate inherent autogenous healing mechanisms aesthesis will unlock the full potential of selfsensing and selfhealing materials and develop an innovative allinone retrofitting solution with tailored functionalities to meet the specific performance criteria of heritage structures thus enabling a paradigm shift from corrective to proactive retrofitting the work will be underpinned by a systematic multiscale multiphysics approach and culminate in the field demonstration of the proposed technology aesthesiss breakthrough will reinforce the european identity by providing safer and resilient heritage structures and will increase europes competitiveness in the retrofitting sector by providing fundamental knowhow on the design of multifunctional systems and practical design tools to promote their faster uptake
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extending the perovskiteinspired mixedmetal chalcohalide alloy space for solar cells
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renewable energies play a central role in the decarbonisation of the energy sector and mitigating manmade climate change photovoltaic pv technology provides a clean safe and affordable renewable source of energy new photovoltaic materials with high power conversion efficiencies are needed to meet the european green deals 2050 targets and to ensure the largescale deployment of solar cells an encouraging material class are perovskites but as they suffer from toxicity and stability problems this impedes their commercial viability one promising alternative are mixedmetal chalcohalides pimmchs which have the potential to overcome these known problems with perovskites and still exhibit good optoelectronic properties thus making them of interest for pv applications however this promising class of materials remains widely unexplored the aim of this project extpimmch is to expand the material space of pimmch compounds and our understanding of this material class i will explore i binary and ii ternary pimmch alloys in order to identify promising pimmch alloys which are suitable for indoor and outdoor pv applications for this purpose i will use a combination of density functional theory dft and machine learning to accelerate the material exploration finally i will identify a few dozen promising pimmch alloys for indoor andor outdoor pv applications to facilitate further experimental research also i will study iii the influence of defects such as vacancies interstitials and antisites on pimmch materials using dft which can be used to determine the defect toleranceintolerance of pimmch materials a profound understanding of defects in pimmch materials is essential because they could have a significant effect on the performance of pv applications overall extpimmch will facilitate the development of efficient stable and nontoxic pscs thus accelerating largescale commercial adoption of pscs
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scaling up capacity to support conduct of clinical trials in the east african community
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the east african community eac has experienced significant increase in volume and complexity of clinical research driven by epidemics of emerging and remerging infectious diseases such as hiv ebola and covid19 requiring expertise in scientific and ethical review and conduct of research and a robust and pragmatic research regulatory framework the overall goal is to strengthen scientific and ethics capacity in eac for high quality research review conduct and oversight at international standards the specific objectives are 1 to train nrra personnel rec members researchers and clinicians on scientific and ethics review and conduct of research with emerging and complex study designs including adaptive platform trials 2 to train nrra personnel and rec members on oversight monitoring and pharmacovigilance of clinical trials and 3 to train nrra personnel rec and research administrators on personal effectiveness and leadership skills pels to manage the increasingly complex research processes methods we will implement this project within a consortium of research scientists from the six partner states collaborating with the eu partner with the east african health research commission as the strong nucleus for coordination and dissemination of results the project will be hosted at the infectious diseases institute idi where within a previous nih funded program 5g11 tw01130901 we built capacity for rec members researchers and rec administrators for 7 recs in uganda with significant improvement in knowledge pels quality and turnaround time of research review and researcher satisfaction this proposal fits within the scope of ghedctp320220105 call whose aim is to strengthen clinical research capacity and improve efficiency of the regulatory environment for effective development delivery and uptake of new and improved safe health technologies and rapid response to emerging epidemics guaranteeing international standards and attainment of sdg3
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quantitative ultrasound stochastic tomography revolutionizing breast cancer diagnosis and screening with supercomputingbased radiationfree imaging
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ultrasound imaging can be deeply enhanced by means of algorithms developed in the field of geophysical imaging such algorithms based upon adjointstate modelling and iterative optimization provide quantitative images of human tissue with very high resolution at present time such images can only be attained by means of highperformance computing and using specific ultrasound data acquisition devices when combined hardware and software have a huge impact potential for softtissue imaging such as in breast cancer imaging nevertheless and as is customary in medical imaging the obtained images only provide with the mean or most likely values of tissue at each pixel being uncertainty quantification an extremely expensive process typically deemed as unfeasible for practical purposes a revolutionary development in adjointbased ultrasound imaging allows us to potentially obtain images of uncertainties at the cost of a single meanvalue image such development will be the basis of transformative implications in terms of confidenceestimates for diagnosis we aim at disrupting the breast cancer screening paradigm by means of a safe radiationfree accurate quantitative and reliable uncertaintyaware novel breast imaging modalitywithin qustom we will investigate the fundamental science behind adjointbased uncertainty imaging and establish its potential suitability for breast cancer diagnosis the feasibility of the technology as a diagnosis tool relies on 1 adapting the data acquisition hardware for optimal resolution 2 implementing the algorithms in highperformance computers in order to obtain a short timetosolution and 3 feasibility analysis by expert radiologists in comparison with the stateoftheart in breast imagingthis proposal covers the three aspects and opens the possibility of applying similar principles in other imaging fields both in medicine and elsewhere
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predicting apoptosis engagement downstream of caspases in vivo
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epithelial cell death is widespread during development and tissue homeostasis while the core pathway of apoptosis is well known we lack predictive power to understand when and where a specific cell will die in a tissue yet this should have important consequences for clone selection and tissue homeostasis as exemplified by the process of cell competition this context dependent cell elimination is essential for tissue homeostasis and tumour progression but we know very little about its prevalence during normal development recent works have characterised multiple nonapoptotic functions of effector caspases and a high frequency of cells undergoing transient caspase activation without death yet what distinguishes a dying from a surviving cell downstream of effector caspase activation is completely unknown using quantitative live imaging of effector caspase sensors and caspase activity tuning by optogenetics in the drosophila pupal notum a single layer epithelium we found that cells engage in apoptosis at very variable levels of effector caspase activity this suggested that the engagement in apoptosis can be developmentally modulated downstream of the most terminal caspase activation and that a completely new layer of regulation of cell death could have important physiological roles here we propose to combine quantitative live imaging multivariate model supervised machine learning and quantitative perturbations through optogenetics to define parameters predictive of the engagement in apoptosis downstream of caspase activation we will then use spatial omics combined with an optogenetic based screening to identify new factors modulating the sensitivity to caspases eventually we will unravel the physiological functions of caspase sensitivity modulation by defining a new paradigm of physiological cell competition and clone selection and characterising its impact on tissue morphogenesis and oncogenic cell elimination
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eegbased diagnosis support solution edison to help close the epilepsy diagnosis gap in low and middleincome countries lmics by combining low capex and aiguided capture with telemedicine
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about 40m people in low and middleincome countries lmic suffer from epilepsyrelated seizures but not all are diagnosed and treated due to the lack of electroencephalogram eeg devices and neurologists in these regionsbraincapture bc is developing an eegbased diagnosis service braincap for epilepsy and other neurological disorders that fits lmic needs since it is affordable uses mobile phone infrastructure and does not need an eeg expert onsite for data capture due to an aibased quality control qc algorithm data is analysed by remotely placed neurologists who provide a diagnosis and treatment plan via the braincap appcloudour field trials revealed that there is a clinical need for braincap now we will finish the product design optimize the qc algorithm and extend clinical validation to multiple sites to convince kols in several primary markets the eic investment will be key to create eeg market in lmics leveraging a significant business opportunity for bc
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chelomics application of multiomics approaches to provide a holistic understanding of siderophore mediated hostpathogen interactions and new diagnostic options for aquaculture fish infections
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outbreaks of bacterial diseases pose a persistent challenge to fish farming around the world causing significant economic loss to improve efficiency safety and sustainability of aquaculture new health monitoring and rapid disease diagnostics approaches are required here we propose an ambitious multidisciplinary project that implements modern multiomics tools in particular metabolomics and metagenomics to provide a holistic understanding of hostpathogen interactions in farmed fish in the context of three major bacterial diseases vibriosis photobacteriosis and furunculosis this project will focus specifically on the metabolome of siderophores iron chelating microbial metabolites that are key virulence factors during infection and their use as biomarkers for early disease diagnostics in nature microorganisms exist in diverse communities and therefore infections can be caused by a combination of species yet the involvement of cospecies in disease progression is poorly understood and represents a great diagnostic challenge i have gained extensive skills in metabolomics through my phd in australia and postdoctoral experience in germany this project will enable me to go one step further i will use different bioinformatic tools as well as imaging analytical chemistry maldiims approaches to integrate metabolomics and microbiome data and answer important ecological questions in aquaculture i am highly motivated to take on this new challenge and acquire new scientific and transferable skills which will strengthen my profile as an independent researcher and increase my opportunities for a permanent position after the fellowship
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beyond the breadline charitable food provision and survival strategies of the urban poor in a comparative perspective
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food charities have become essential pillars in assisting the urban poor offering a crucial buffer between food insecurity and hunger their significance particularly after the great recession is underscored by two pivotal shifts one towards the sustainable utilisation of food surplus and waste reduction and the other reflecting societal changes with diminishing welfare benefit provision while considerable research addresses food insecurity and support the literature lacks a robust framework to understand and compare charitable food provision cfp across countries and cities despite the almost universal occurrence of such transitions existing studies have not yet contextualised this phenomenon within the diverse arrangements of welfare and civil society regimes and the influence of transitions in agrifood sustainability on cfp accordingly this proposal aims to1 use event sequence analysis to chart the historical trajectory of cfp in italy japan and the netherlands examining the emergence and consolidation of professionalised cfp sectors in diverse institutional settings2 adopt mixedmethods social network analysis to examine current cfp dynamics in palermo kyoto and rotterdam focusing on providers interrelationships operational modes and their ties with both state and nonstate authorities3 harness urban ethnography to investigate the interdependence between food insecurity and support to understand how cfp becomes part of poor peoples survival strategiesadditionally it introduces an innovative tool tailored for city workshops to facilitate realtime data collection on cfp urban dynamics hence it combines the findings obtained by crafting an overarching framework to extend cfp comparison to other countries and cities the research will create new knowledge across urban sustainability organisation food and social policy studies offering an innovative comparative insight into food support and insecurity
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extremescale urban mobility data analytics as a service
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emeraldss vision is to design develop and create an urban dataoriented mobility analytics as a service maaas toolset consisting of the socalled emeralds services compiled in a proofofconcept prototype capable of exploiting the untapped potential of extreme urban mobility data the toolset will enable the stakeholders of the urban mobility ecosystem to collect and manage ubiquitous spatiotemporal data of highvolume highvelocity and of highvariety analyse them both in online and offline settings import them to realtime responsive aiml algorithms and visualize results in interactive dashboards whilst implementing privacy preservation techniques at all data modalities and at all levels of its architecture the toolset will offer advanced capabilities in data mining searching and processing of large amounts and varieties of urban mobility data and its efficiency will be assessed validated and demonstrated in three trl5 pilot use cases by following a codevelopment approach with mobility and city stakeholders to improve decision making in urban smart city environments and deployedshowcased in two early adopters datadriven trl6 applications by integrating the new services to existing systems to improve commercial offerings
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optimization of fastion confinement against edge instabilities for future fusion reactors
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the project presented here deals with fastion confinement optimization ficop in magnetically confined fusion reactors the goal of the project presented here is the characterization of the effect of edge instabilities on fastion confinement and the understanding of the physical mechanisms behind this interaction as well as to experimentally explore the conditions upon which ion runaway can take place in tokamaks by studying the behaviour of fastions in the current rampup and rampdown phases disruptions and sawtooth crashes to fulfill these objectives novel and cuttingedge data analysis techniques will be developed to be applied to fusion diagnostics including integrated tomography techniques and deep learning the results of this project are expected to have a direct impact on the fusion community the problem of power exhaust in tokamaks mainly focuses on the power dissipation through the divertor plates therefore the limits to tokamak operation are set based on the heat fluxes that the materials in the divertor plates can tolerate however an additional constraint might come from the fastion heat loads due to edge instabilities that may deposit power not only on the divertor plates but also in the first wall of the main chamber often in localized areas the results of this project may help to assess weather fastion heat loads to the main chamber first wall due to edge instabilities can pose an additional constraint to the operational regime of a tokamak fusion reactor or eventually impact its design by the addition of reinforced structures the experimental results of the project will also be used to benchmark the stateoftheart codes that the fusion community uses to make projections towards future machines if successful the benchmark will strengthen our confidence in our predicting capabilities while if unsuccessful the results will motiv
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accelerating transformation through capitals knowledge
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the overall goal of atrack is to consolidate and mainstream activities to accelerate transformation in organisations such that by end of project a critical mass of businesses financial institutions and governments integrate the value of natural capital in their decisionmaking helping to halt and reverse biodiversity loss in doing so atrack will contribute to delivery of the european green deal atrack builds on existing initiatives and best practice to develop pilot test demonstrate and scale innovations in this space specifically atrack will 1 develop and demonstrate the use of robust information pathways that facilitate flows of biodiversity information for use in business and financial decisions and the compilation of public and private sector natural capital accounts 2 strengthen the life cycle assessment of biodiversity and ecosystem services footprints for products and organisations integrating and further mainstreaming these with natural capital approaches and materiality assessment practices 3 mainstream and advance natural capital assessment and accounting in businesses and their integration in decisionmaking across key sectors and business functions 4 facilitate and incentivize the adoption and scaling of naturepositive business models 5 nurture financial innovations to scale naturepositive finance based on reliable natural capital data and practice emphasis is placed on integration synthesis and wide engagement across this work this will deliver wider impacts in europe and beyond through global value chains in terms of enhanced natural capital and biodiversity enhanced competitivity of european businesses in the new nature economy and improved wellbeing derived from enhanced ecosystem services atrack brings together an intersectoral and interdisciplinary consortium of leading players who are involved in many of the key related frontrunner initiatives across this space ensuring appropriate synergies
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quantum dynamic control of atomic molecular and optical processes
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the project represents a coordinated experimentaltheoretical effort in developing and testing quantum protocols within a worldwide academy and industry effort to develop quantum computers based on quantum qubits and quantum hamiltonian the quantum protocols ie well designed hamiltonian acting on the qubits represent important steps even if the qubits offer enormous computation power the quantum target may be reached more efficiently more rapidly and with more stability using properly designed quantum protocols within this project these new protocols will be tested on the natural qubits easily assessed in worldwide research laboratories simple atoms and molecules the experimental and theoretical tools should be classified with the broad area of quantum optics where the photons typically from laser sources create the control quantum protocols and the atomsmolecules constitute the qubits where quantum information is stored and maipulated the project will apply this quantum control approach to open theoretical and experimental problems such as implementation of a molecular alloptical spin switch via control of spinorbit interaction realization of molecular orientation superadiabatic protocolsfor the coherent control of cold atoms and molecule control of ultracold chemical reactions and spinpolarized quantum emitters the objectives of the project will be achieved via an intensive transfer of knowledge among the eu and tc participants in the consortium during the carefully planned secondments the consortium members are well established specialists in various aspects of physics of lightmatter interactions including theoretical experimental and numerical techniques and therefore all participants will benefit from the se scheme for staff exchange to collaborate and achieve new results in this area the gender balance in the consortium is well kept with three of the team leaders being female
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mapping the methylation of repetitive elements to track the exposome effects on health the city of legnano as a living lab
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the concept of exposome encompasses all human disease determinants encountered during the life course the exposome induces epigenetic modifications eg dna methylation several studies have investigated how repetitive elements res can be switched on in response to environmental stimuli but have started from the assumption that altered re methylation is always detrimental to the health of the affected individual mameli proposes an alternative hypothesis that some res are plastic entities that respond physiologically to the environment consequently the ability of dna to adapt to environmental triggers can be monitoredto test this hypothesis the mameli project will enroll 6200 subjects in the city of legnano italy the firstlevel discovery will apply thirdgeneration sequencing methylation assessment on 200 subjects at twotime points t0 baseline and t1 6 months after t0 the discovery level will allow me to define a pool of res differential res whose methylation can change without impacting genome stability the second level tuning will be conducted on 2700 subjects 200 subjects of the discovery level 2500 additional subjects and will allow me to develop an algorithm mameli algorithm to predict the relationship between exposome and re methylation status re methylation signature in the third level validation i will apply the mameli algorithm on the second set of the study cohort n3500 to calculate the difference between the measured re methylation signature and the values predicted by the algorithm in addition to test the reversibility of re methylation following lifestyle modifications and its preventive potential i will design an intervention study embedded in the cohortmameli would represent a breakthrough in the understanding of individual susceptibility to environmental pressures enabling the development of preventive strategies to avoid disease
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how do drugassociated contexts drive behaviour the role of entorhinal circuitry in addiction
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addiction to drugs is a ubiquitous neuropathological disease that inflicts immense societal costs a core aspect of addiction that poses a major challenge for treatment is the propensity to relapse in environmental contexts that are associated with drug use identification and mechanistic characterization of novel addictionrelevant circuitry linking the motivation to take drugs to the complex spatial and nonspatial features that constitute a drugassociated context are at the core of this proposal these insights will be used to identify the best constellation of anatomical targets to prevent and reverse the expression of contexttriggered drugseeking the medial and lateral entorhinal cortex mec and lec are two central components of the episodic memory system integrating all features relevant for the formation of contextual memory crucially mec and lec receive strong bottomup dopaminergic input from the midbrain and send topdown projections to the nucleus accumbens nac the dopaminergic system is the primary target of all addictive drugs we will 1 study how bottomup dopaminergic projections are implemented into drugcontext associations in mec and lec and 2 determine how these associations influence nacmediated drugseeking behaviour we will utilize a multidisciplinary approach by developing electrophysiological in vivo recording paradigms in behaving mice that allow the assessment of complex spatial contextual and nonspatial codes in conditioned place preference and selfadministration paradigms typically used to model addiction in rodents this will be combined with optogeneticallyassisted circuit analysis of molecularlydefined pathways to link identified functions to the underlying circuitry pathwayspecific optogenetic silencing will be used to prevent and reverse the manifestations of drug use on a neuronal and behavioural level this will guide the evidencebased development of therapies in the future such as deepbrain stimulation
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enhancing the sustainability of photopolymers and photoinduced processes
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esperanto enhancing the sustainability of photopolymers and photoinduced processes aims at i improving the sustainability of photopolymers ii boosting the use of photopolymerisation processes in the industrial sector to replace less sustainable processes iii training a new generation of researchers with advanced scientific skills and sustainability consciousness gathering 8 universities and 8 nonacademic partners esperanto will reach its objectives through individual phd projects addressing sustainable innovation within an international and intersectoral research network of academic institutions and enterprises in the field of photopolymers and hightech photopolymerization is a key enabling technology for coatings adhesives printing inks packaging wood finishing and electronics photoinduced reactions are greener than most chemical processes as they do not use solvents are not energy intensive are fast and efficient however they still present sustainability issues namely use of fossilbased raw materials migration of components during the service life of the product limiting their use in medical and food applications need of harmful uv lights and limited applicability to thickopaque samples or nonilluminated areas furthermore photopolymers are mostly crosslinked thus nonrecyclable esperanto will tackle the technical and environmental issues of photopolymerisation developing greener and safer materials for present processes and investigating innovative photopolymerisation processes implementing new sustainable materials and prototypes based on new photoprocesses it will set innovative and sustainable lightbased technologies able to enter new markets eg the medical sector and innovate existing ones making an impact on eus economy moreover esperanto will prepare highlyskilled and employable researchers with strong environmental consciousness strengthening europes human capital base in sustainable ri
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the pursuit of wellness in southeast asia new encounters and inequalities in an emerging industry
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wellasia studies the commercialization of wellbeing as wellness in twentyfirst century southeast asia a region with one of the fastest growing wellness industries in the world people from within and beyond asia are travelling more than ever before in search of yoga meditation and spa retreats detoxifying diets antiageing therapies and emotionallyhealing experiences this growing interest in wellness takes shape in the context of increasing anxiety longevity in a rapidly ageing world and a growing global middleclass wellasia examines the people and places involved in producing sustaining and contesting the idea of wellness in contemporary asia the project asks what social economic and moral transformations and what new patterns of inequality does the pursuit of wellness generate how are diverse interests brought into tension and negotiated in the transnational encounters between i those who labour in the industry ii the travellers who consume its services and iii the local communities involved situated in southeast asia where multiple healing traditions circulate transnationally often with deep historical roots this multisited ethnographic study focusses on three sites that exhibit both the diversity and distinctiveness of wellness in the region singapore chiang mai and ubud the project will involve an interdisciplinary team working in the fields of social anthropology political and economic geography media and cultural studies wellasia contends that the expansion of commercial wellness is unevenly transforming local economies reconfiguring transnational mobilities and bringing to light emergent highly mobile and marketable visions of what it means to be well in a hypercapitalist and interconnected world in ways that transcend the boundaries of health itself
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local food supply communicated through a transactional searchable map based application foodmapp to promote short food supply chains food security business development and reduction in food waste
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interconnected challenges of climate change food supply resilience food miles food waste and supporting the next generation of producers and operators with a fair income are all highlighted in the eu strategic plan foundational redesign of our food supply systems is required with urgency to address these challenges and accelerate the twin green and digital transitionscurrent industrial scale food producers and processors lead to complex supply chains that are disconnected from local communities and a rebalancing toward more local supply is sought to address these challenges the objective of foodmapp is to lead this transformation of food supply by enabling and promoting transparent local provision from local producers including small scale family farmers and processors direct to consumers foodmapp will for the first time gather extensive market intelligence from all stakeholders including producers processors consumers to understand market demand and preferences towards localised food supply transparency this underpinning research will inform the development of a dynamic searchable mapbased platform enabling local providers to supply and sell produce directly to consumers food supply from small scale family farmers local processors and food service operators will be included the platform will be trialled with local communities and refined prior to full exploitation and comprehensive dissemination to stakeholders and policy makersthe project brings together a consortium of leading experts in the fields of agrifood economics technology development food supply chains psychology and consumer behaviour four academic beneficiaries will be partnered with four industry partners with extensive networks and experience in food supply systems exchange between these partners will be optimised to deliver strong personal development of individuals collective development of all beneficiaries and capacity building in this critical ri area
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modelling and maintaining maternal mental health
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pregnancy loss oftentimes yields extensive negative consequences on the mental health of the affected women and their families yet it is a largely neglected factor in global health while we have started to gain insights into how pregnancy shapes the female brain toward motherhood the impact of the abrupt termination of pregnancy on maternal brain plasticity remains largely unknown here i seek to study traces of unwanted terminated pregnancy following early and late pregnancy loss in the female brain understanding to what degree motherhood associated changes in brain anatomy and function are formed back when a pregnancy is lost i aim to identify traces and determinants of afflicted mental health in this period of profound vulnerability and selfstigmatization leveraging my portfolio of expertise in multimodal brain imaging statistical genetics and computational psychiatry the healthymom project will acquire unique longitudinal data of the weeks and months following early miscarriage or stillbirth specifically women will undergo repeated brain imaging hormonal assessment and a comprehensive monitoring of their mental health i will perform whole genome sequencing not only of the women but also of their life partners together with detailed surveys this will allow me to uncover how individual brain trajectories relate to environmental levers for mental health maintenance and to genetic risk factors including genetic effects of the partners on the women the project will draw on existing big data and advanced computational modelling techniques to chart individual brain imaging patterns in the context of the population norm as such healthymom offers unprecedented opportunities to understand femalespecific brain dynamics and to reveal neurogenetic signatures of mental disorder vulnerability as well as targets for maintaining maternal mental health it has significant implications for womens health and indirectly the health of future offspring
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algorithmic contract design
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no algorithm is an island algorithms constantly interact with selfinterested players algorithmic game theory agt has thus far concentrated on one aspect of this the algorithms input is reported by such players incentivizing truthful reports is the focus of mechanism design in economics and in agt algorithmic mechanism design became a hugely successful research area we propose to apply the algorithmic lens to a different but no less important field in economics called contract design recognized by the 2016 nobel prize the essence of a contract is to incentivize players actions rather than reports it is thus extremely relevant to another way in which algorithms interact with players the algorithms output is carried out through their actions we refer to the new research area that will emerge as algorithmic contract design acdwe aim to lay the theoretical foundations for acd typically computational environments are more complex than traditional economics ones key complexities are1a rich choice of actions makes computing an optimal contract nontrivial 2the optimal contract can be unintuitive and brittle3a onesizefitsall contract is suboptimal for a diverse player population4multiple contracts can undermine each other 5traditional contract formats can be too weakwe will tackle these complexities designing the next generation of algorithmic incentive schemes for strategic action tractable simplerobust personalized and coordinated and develop new contract formats en route the potential impact of acd is farreaching first it will prevent traditional algorithms from failing due to selfish action choices second given the current influence of algorithms on behavior it will help achieve a more sociallyefficient allocation of effort applications include traditional contracts moving to online platforms like freelancing as well as novel datadriven incentive schemes for domains like digital healthcare
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efficient organic photovoltaic sensors
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the project efficient organic photovoltaic sensors effector will deliver innovative and environmentallyfriendly solutions for digital and wearable electronics at trl7 these objects will be individually powered by harvesting lowlevel light and will be made from sustainable materials for a bright digital future effector will contribute to a strategic position through an open economy in the key digital and humancentric emerging technology by developing highly sustainable energy harvesting under diffuse lowlight conditions in the key areas of security and healtheffector will create new sustainable european value chains for photovoltaic technologies and open new innovative businesstobusiness operations by doubling the efficiency of nontoxic organic solar cells for use under lowlevel light it will couple in a streamline way with nontoxic sustainable supercapacitors with advanced low power electronics the effector strategy is to bring solar cell technology to mainstream use by eliminating the need for mains electricity from everyday humancentred electronics it will develop sustainable materials and processes using nontoxic materials and reducing environmental impact applicable for a huge raft of humancentred technologies and innovations effector draws on the worldleading inkjet opv manufacturing of dracula technologies the sustainable nontoxic aqueous supercapacitors of innocell and the high fidelity power management systems from epeas with its worldleading academic partners in solar cell design sdu high throughput industrial electronic printing and integration vtt and polymers for solar cell stabilization cnrs it will demonstrate this innovative multifaceted approach in vital health monitoring with polar and portable device applications with cardlabs biometric card technology effector will demonstrate how lowlevel and indoor light can power our future in a secure reliable and sustainable way
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electrification of high temperature and flexible technologies for transforming cement lime and pulp industry
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electra demonstrates that electric heating can substitute fossil fuels in the cement lime and pulp industries electra develops and validates in real life emissionfree electrically heated cement and lime production process in mw scale capable of reaching temperature up to 2000c by using lowemission electricity instead of combustion for decomposing calcium carbonate and by capturing the carbon dioxide produced in the production process it is possible to run a cement plant with close to zero carbon dioxide emissions providing even negativeemission cement and lime products for the society successful implementation of electra will eliminate fuelrelated co2emissions from the industries targeted by 3050 of total process emissions depending on the industry and mode of operation scalability and replicability is showcased by the platformbased solutions offering modularity and the possibility is there to run in various hybrid modes in a transition period lowering initial capex they allow for both new electric installations and revamping of old ones platformbased modular automation practices can potentially accelerate electrification by up to 5 years different applications also require different properties for lime and therefore variations of electrically heated processes are developed to support and complement mw scale demonstrationreplacing combustion processes with electricitybased solutions and significantly increasing emissionfree electricity production is an effective means of mitigating climate change as one of the ingredients for concrete cement is the worlds most used building material and globally the largest co2 emitter of all industrial sectors the results of electra contribute directly to the ambitious goal of eliminating direct co2 emissions from the lime paper and cement industries the developed fully electrified solutions for calcination and clinkering will offer the cheapest option for decarbonation for these industries
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clinical validation of an aibased approach to improve the shared decisionmaking process and outcomes in breast cancer patients proposed for locoregional treatment
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breast cancer is the most commonly diagnosed cancer with an estimated 23 million new cases per year globally approximately 90 of these patients will undergo breast surgery withwithout radiation locoregional treatment different surgical techniques can be offered to the patient each leading to completely different aesthetic outcomes moreover for different patients undergoing the same surgery the aesthetic outcome could be completely different based on individual patients factors eg age body habitus in the cinderella project we will be using the brelo ai system an artificial intelligencebased tool for classification of aesthetic outcomes and matching data and photographs integrated in cankado a cloudbased healthcare platform to create an easytouse application that can be used on any electronic device to simulate visually to the patient the aesthetic outcome of a certain surgery the cinderella approach is unique as it uses a clinical database and performs biometric matching to create images that simulate to the patient the outcome of surgery in the cinderella trial running during the project we plan to compare if the application helped to fulfil the expectation and lead to a better quality of life by feeding new clinical and photographic information to the cinderella approach after surgery the artificial intelligence platform will be able to improve for the next cases this trial will be practicechanging in the field of patient education and shared decision making cinderella platform will help to overcome any miscommunication and potential boundaries in patients or physicians understanding of the potential outcomes of locoregional treatment of breast cancer we believe that the cinderella approach will be used in the future to other locoregional treatments that might change patients aesthetic appearance thus cinderella approach will be the forerunner for new innovative tools for communicating with our patients
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field quantum gravity sensors
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gravimetry aims at unveiling the density structure of the undergrounds by measuring subtle changes of the local gravity acceleration the firstgeneration of quantum gravity sensors qgs has received a strong interest from many customers and the market is still growing but the commercial potential and the positiveimpact of the technology are not yet fully exploited because of several limitations such as transportability robustness userfriendless or high operation costs to overcome the barriers that limit the operational utilization of field gravimetry and develop the solutions that will allow us to fully address the exploitable market we propose to conduct in fiqugs the development of several innovations either at the technological level with improved qgs built upon a reliable and efficient supply chain or in terms of operational methodologythe development of a next generation qgs product line and the services associated for the conduction of field surveys data acquisition and data inversion will allow to considerably develop our capability to address the market of advanced geophysics the unique industrial and technological capabilities that will result from fiqugs will positively contribute to several important societal objectives especially the european green deal the new field qgs will allow for a reduction of the environmental impact associated to mining activities thanks to a reduction of drilling operations and civil engineering where it will contribute to more efficient and resilient constructions they will contribute to an improved utilization of geothermal energies through the development of noninvasive monitoring capabilities of the energy reservoir they will be involved in co2 storage operations and will contribute to the fight against global warming thanks to these advanced monitoring capabilitiesfiqugs will also have an impact in quantum technologies markets such as highperformance navigation or advanced photonics
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a pioneer clinical trial management system to automatically collect review and analyse prospective clinical trial data to prompt faster development of novel therapies
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yonalink yl is an israeli company established in 2018 with the mission to disrupt the 46b clinical research market by connecting the world of prospective clinical trial data to this end yl is developing the yl system a platform to migrate clinical research data saved in the patient health records from medical centres to research databases in an automated secure validated trusted and errorfree way the company has secured over 18m in the development of the yl system reaching trl 7 with pilot trials implementing it at soroka mc clalit health insurance leading hospital and in sheba mc the trials have confirmed the accuracy in migrating patients deidentified data from the ehr to the trial db eic support will allow yl to finish optimization and validate the yl system in a multicentremultinational pilot demonstrating the advantage of automatic data transfer from ehr to the prospective trial database to all the clinical trial stakeholders in the eu
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graphene transistors for highdensity braincomputer interfaces
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we have developed a novel type of graphenebased transistors capable of delivering highresolution brain mapping implementing multiplexing strategies and monitoring activity across a wide range of frequencies including low frequencies we circumvented the bottlenecks faced by other approaches thanks to the unique properties of graphene graphene is an outstanding conductor and provides the perfect platform for multiplexing thus our system requires much fewer wires than current alternatives further graphene is just one atom thick flexible and can be integrated into ultrasoft flexible substrates providing excellent contact with brain tissue our graphene transistor technology has been developed as part of the fetgraphene flagship and fetproactive braincom projects we have assessed the technology in rodents and demonstrated that our devices allow monitoring brain activity with very high spatial resolution and over a wide bandwidth frequency range this project will pave the way for the clinical translation of brainmapping neural interfaces based on graphenetransistor arrays for braincomputer interfaces
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powerful lawful interception investigation and intelligence
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poliiice vision is to advance european leas to a novel lawfulinterception li investigation and intelligence era in which they will be able to effectively prevent detect and investigate crime and terrorism amid the new age of communication 5gbeyond endtoend encrypted communication and quantum based encryption these new age technologies turn legacy li solutions to totally ineffective and therefore put significant risk on europes fight against crime and terrorism poliiice will offer research validate and demonstrate array of innovative li measures at cloud network level as well as at edge device level that together will enable leas to efficiently overcome the new age challenges and enable high throughput of its li in addition poliiice will research and model quddaas quantum unlock detection and decryption as a service as an envisaged central service potentially outsourced at pan eu level which will harness quantum computing for decryption of lawfully intercepted encrypted communication which is vulnerable to quantums shor algorithm for brute force detection of targetusers credentialstokens needed to access encrypted cloudnative apps and for quantum unlock of lawfully seized edge devices quddaas may also detect and classify li communications that are resistant to quantum decryption power and therefore cant be decrypted poliiice also aims to improve the information exchange and cooperation among european leas by proposing and implementing a mechanism and procedure for exchanging pseudoanonymized suspect identifiers poliiice is designed for ensuring the costeffectiveness security and integrity of the new age li and will provide the legal and ethical framework for each of its measures while strictly complying with privacy preserving and ethics rules of operation poliiice will contribute to the li standardization and will recommend eu regulation changes for effective adaptation of poliiice vision and innovative li measures
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fellowship residencies offering science news professionals tools and training for independent and ethical reporting on science
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the overall objective of frontiers is to establish a program supporting science journalists residencies in european research institutions through a financial support to third parties mechanism the program aims to and contribute to tackling the challenges of science journalism specifically in the highly challenging area of frontier research as well as increasing the opportunities of interaction between research institutions and science journalists the residency program will be established based on the principles of journalistic independence and the need for coverage of frontier as oppose to other types of research to ensure a smooth and successful operation we will develop a coordination and support office cso that will oversee the development and implementation of the residency program and the ongoing management and monitoring the cso will also provide support and complementary services including a general and frontier science helpdesk for journalists researchers and staff from hosting research institutions matchmaking services to help journalists find hosting institutions our project activities will be supervised and accompanied by a strong advisory board consist of actors from the areas of science and science journalism ensuring the independency and credibility of the program resident journalists and researchers and research staff participating in the program will also benefit from training activities and content contributing to the creation of meaningful journalistsresearcher collaboration and the generation of highquality and credible science journalism products during the project we will also benchmark the frontiers residency program to other available programs offering fellowships to science journalists and implement best practices to ensure the quality of the program finally we will explore paths towards sustainability the residencies through additional funding channels
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quantumsafeinternet
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qsi aims at training a worldclass cohort of doctoral candidates dcs capable of taking the next essential steps in the highly demanding area of cybersecurity we aim to build strong lasting links between strategically selected industry and academic partners in different disciplines via the development of novel technologies for practical applications in data security in parallel we will also combine via a collaborative longterm interdisciplinary approach expertise in all relevant communities to address key fundamental problems in secure communications in the quantum era and the important applications therein the planned training network will provide research and training opportunities to a new generation of dcs who in the longrun shall address the grand challenge of providing quantumsafe internet ie a communication infrastructure that is secure against not only classical attacks but also those enabled by quantum technologies todays internet security heavily relies on computational complexity assumptions and as such is seriously threatened by advancements in quantum computing technologies indeed we have recently witnessed a wave of key developments in this direction by a number of it giants eg google ibm microsoft and intel this particularly jeopardizes applications that require longterm security the number of such applications is continuously growing as more and more of our private information is stored and communicated in a digital way eg electronic health records which are now required by european legislation to remain secure for a long time this requires us to urgently develop and implement new solutions as we plan to do in this doctoral network dn
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the mutual effect of levels of trust and regulation over time analyzing energy regulation in the european union
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trust and regulation are key aspects that allow the advancement of the society in setting regulations to govern the behavior of citizens firms states and policymakers adopt regulatory design choices that are partly grounded in trust between them and key actors in the field at hand however we do not know a lot when it comes to iterative processes through which trust and regulation affect each other over time through a combination of quantitative and qualitative methods truregen aims to study the bidirectional relation between levels of trust and regulation focusing on the case of eu energy regulation during 20082022 the project 1 maps the nature of eu energy regulation along two key dimensions specificitybroadness stabilityrevisability 2 assesses statistically significant relations between such a nature and current and past levels of trustdistrust among key eu and national actors policymakers regulators regulatees consumers citizens and 3 traces causal mechanisms underpinning these statistically significant relations expertise and facilities offered by the host ku prof latusek together with my existing experience and talent mutually reinforce my development as independent researcher during the fellowship in addition advanced training eg statistics grant writing science communication twoway knowledge transfer allow me to realize my longterm career goals after the fellowship a customized dissemination and communication plan will make the project and its results known well beyond the academic community while also seeking active engagement with a wider audience eg workshops class experiments altogether truregen at once bridges a major scientific gap enhances my future career prospects and makes a timely contribution to pressing societal debates
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the formation and evolution of the primordial planetary felsic crust
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a turning point for the whole planetary evolution climate and habitability was the onset of felsic ie enriched in si and al crust formation 45 40 gyr ago to date this onset can be traced using natural zircon mineral zrsio4bearing rocks as well as laboratory experiment and modelling my project is based on cuttingedge experiments and modelling as well as field data acquisition on natural rock samples to construct a first comprehensive fundamental model of the primordial felsic crust formation and evolution on earth and very likely mars and venus my recently established laboratory experimental protocols and modelling approaches open a new window to understanding of how the zirconbearing felsic magmas rocks and crust can be produced from the ultramafic rocks mg ferich and si alpoor that dominated early planets compositionplanetafelsic has four research objectives i to identify and explore the rockforming processes that controlled the formation and evolution of the primordial felsic crusts on earth mars and venus ii reevaluate what physicalchemical conditions are reflected by the trace element and isotope signatures of zircon formed and evolved in the presence of magmas and fluids iii to constrain the initial steps of planetary geodynamics ie rockforming reactions transformations and movements and how they are recorded in the trace element and isotope signatures in mantlederived rocks iv to construct a geochemical model of the habitable conditions during the early evolution of the rocky planetary surfacewith planetafelsic grant i will build a team dedicated to addressing these challenging goals in a comprehensive way ambitious but feasible and timely planetafelsic will significantly advance our understanding of how the habitable conditions could be formed on the planetary surface this will pave the route for future missions to mars and venus and exoplanet exploration
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interplay between chirality spin textures and superconductivity at manufactured interfaces
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memories that operate at cryogenic temperatures are urgently needed to realize advanced quantum and superconducting computing systems that will enable more efficient and scalable computing systems beyond todays reach supermint proposes to combine the latest advances in superconductivity and spintronics to build a novel supertrack cryogenic memory that is high performance nonvolatile and that needs very low energy for its operation a major objective will be to demonstrate the generation and use of triplet supercurrents that are dissipationless but which carry spinangular momentum to move chiral domain walls in magnetic racetracks a second major objective will be to explore the origin and utilize our recent discovery of a nonreciprocal josephson diode effect to build a novel device to detect magnetic fields and thereby read magnetic domain walls for supertrack these objectives will be met by exploring and designing manufactured interfaces or mints that combine superconducting and magnetic ultrathin layers using an advanced complex of thin film deposition systems that i have constructed over the past 5 years to achieve these objectives fundamental breakthroughs are needed in the preparation of mints with highquality interfaces a wideranging exploration of mints formed from superconducting layers with chiral antiferromagnets homochiral layers of chiral compounds especially from the b20 family of materials and geometrical chiral structures will be undertaken in addition the concept of obstructed atomic insulators that we have recently developed will be used to identify novel interfaces of insulating materials that are metallic and thereby to explore the possibility of making these superconducting by pairing electrons via chiral antiferromagnetic fluctuations in adjacent layers
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in silico clinicallyviable assistive tools for prediction and rehabilitation of knee osteoarthritis
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knee osteoarthritis koa is a leading cause of disability worldwide with 14 prevalence in europeans aged over 40 koa prevalence continues to rise thus far with no cure or proven prevention protocols nonetheless an aberrant knee mechanobiological environment is known to accelerate koa development tailored rehabilitation aiming to favorably alter knee biomechanics and restore the joint has shown great potential to postpone or decelerate koa progression but current rehabilitation protocols are based on indirect measures of knee biomechanics often leading to suboptimal outcomes computational models have offered great potential for simulating knee mechanical response in functional activities though none are developed in a holistic and individualized context more importantly they lack the prediction capability of tissue degenerationregeneration to loading and the potential for clinical use ie are not automated and fast and cannot use outoflab motion data in this project i will develop and validate highly personalized in silico tools to quantify knee cartilage mechanobiological degenerativeregenerative response geared towards outoflab and clinical use for predicting koa progression in different functional activities allowing personalized rehabilitation the multiphysics computational models assisted with artificial intelligence ai will be validated at different spatial scales using in vitro tissue and cell level experiments and in vivo joint loading and quantitative medical images this multidisciplinary project bridges together complementary skill sets of dr esrafilian profs korhonens and delps teams with their expertise in biomechanics computational modeling biochemistry biology and ai the beyond stateoftheart models of this research can make a profound impact on earlystage koa prediction and treatment planning potentially increasing the quality of life in koa individuals and reducing the need for surgical interventions
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developing an abductive coding analysis toolkit
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in qualitative data analysis oriented towards theorybuilding many data analysts anchor their methodological approach explicitly or not in grounded theory however as research in teams develops handling larger amounts of qualitative data enabled by technological developments grounded theorys principles are increasingly at odds with current practices and analysts of qualitative data are left relying on coding procedures that do not match their realities following a burgeoning literature and building on the ercfunded qualidem project we argue that shifting to an abductive approach of coding that combines deduction and induction at different stages of data analysis provides an epistemology to qualitative research that aims at theorybuilding this poc aims to develop abduction as a method of qualitative data analysis by providing a toolkit for abductive coding the abductive coding analysis toolkit acatoolkit the acatoolkit includes three main components 1 a practical guide 2 an educational program for training 3 an overview of the potentials and limits of existing qda software for abductive coding the toolkit thereby targets several audiences academics instructors data analysts and software developers our pathway from research to innovation consists of three steps 1 mapping the existing practices and tools of abductive coding in different disciplines through a systematic literature review whose results will be presented in a technical report 2 developing our abductive coding analysis toolkit through research collaborations and consultancy agreements with stakeholders educators software developers and data analysts synthesized during two cocreation workshops 3 testing the acatoolkit with different potential endusers during five in situ tests with researchers students educators software developers and data analysts the toolkit aims to be free attractive widely applicable and with a wide disciplinary range
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go it
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europes it hardware development is constantly challenged by outrageously expensive development tools legal constraints like ndas or patents lockin threats dependency from external vendors or supply chains and foreign political events europes digital infrastructure from consumer to critical appliances is heavily relying on foreign closedsource chips which are literally blackboxes which may and have been proven to contain malicious features this situation makes the hardware development expensive and inefficient and undermines the very principle of sovereignty resilience and reusability opensource silicon chips which are open in their entirety ie down to the physical layout carry the potential of catapulting europe into a renaissance of digital technology several challenges are on the way many of which will require the participation of the stakeholders from the fertile ground made of nerdy hobbyists and makers who are the early protagonists of the scene all the way up to large enterprises as well as the participation of policymakers and regulatory bodies the road ahead is steep but rich of rewards therefore we loudly say go it
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tokmat truth objectivity and knowledge rethinking the social construction of mathematics
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like all human undertakings mathematics is pursued promoted and developed by socially and culturally situated practitioners immersed in the complex collectivities of their communal practical and institutional affiliations however while few would oppose viewing any other major artistic social political or religious undertaking as socially constructed social constructivism in mathematics specifically regarding the notions of truth and objectivity remains highly contested among historians and philosophers of science and mathematics the tokmat project uses intuitionism in order to develop a new technique for understanding the concept of truth in mathematics this technique will be based on a conceptual analysis of the ideas of truth realism objectivity and knowledge in mathematics through the prism of social constructivism intuitionism presented an alternate mathematical framework to classical mathematics that viewed mathematical entities as creations of the mind as intuitionism acknowledges the social constructivists claim that truth is a wholly human construction it is a springboard towards a widereaching rethinking of the main constructivist account of mathematics as a nonmainstream mathematical school whose ideas are still being discussed intuitionism is a springboard towards exploring the social organization of scientific knowledge and its impact on our understanding of concepts like truth and objectivity the project therefore brings together the history sociology and philosophy of mathematics in order to provide new ways of understanding the notions of truth and objectivity in mathematics as shaped by both external and contextual elements in doing so this project aspires to contribute to the heady debates on epistemology philosophy of mathematics and the social constitution of warranted knowledge
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structural neuroimaging in adhd brain development from childhood to adulthood
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attention deficit hyperactivity disorder adhd is one of the most common neurodevelopmental disorders with 5 of children and 25 of adults being affected core symptoms include inattention hyperactivity impulsivity and cognitive dysfunctions causing a significant burden in multiple domains of daily life delayed brain maturation in childhood and adolescence is suggested as neurobiological underpinning of adhd but longitudinal studies are scarce and have partly revealed divergent results the aim of the present project is to investigate the neurobiological mechanisms underlying the developmental course of adhd within an independent closely monitored and wellcharacterized longitudinal sample dutch neuroimage cohort brain anatomical scans of initially 1069 children with and without adhd will be analysed with regard to the development of cortical thickness surface area and subcortical volumes from childhood over adolescence into adulthood an additional ultrahigh field 7 tesla brain scan acquired in young adulthood will be used to precisely investigate cortical myeloarchitecture all measures will be analysed with respect to clinical outcomes that is comparing patients with persistent adhd patients with adhd in childhood who have remitted into adolescence or adulthood and healthy controls to further understand what mediates or moderates individual differences in adhdassociated brain maturation the role of genetic and environmental risk factors will be considered this project is expected to lead to an enhanced overall picture on the developmental trajectories of adhd identification of interindividual differences between individuals with persistent adhd and those who recover as well as influencing factors will not only provide further insights into the neurobiological underpinnings of adhd but could also have high value for individualization and optimization of treatment approaches
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euchinabridge building roadmaps to industrial decarbonisation and green economy through euchina cooperation
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euchina bridge will support the transition to a climateneutral and resilient society in both europe and china by jointly advancing knowledge on technology innovations and roadmaps for decarbonising energy intensive industries cocreating innovative modelling by combining cuttingedge bottomup and integrated assessment modelling to quantify netzero sustainable pathways and developing the most updated and comprehensive emissions data it will intensively engage relevant stakeholders from both regions enhancing dialogues and fostering mutual learning among policymakers industries and experts it will deliver two opensource euchina joint technology inventories of promising netzero emission technology options for the iron steel and chemical industries two coimplemented demonstrations of promising technologies in china and cocreated scaleup paths and roadmaps of the selected industrial technologies in both regions it will also develop the most uptodate highresolution multisectoral national and regional ghg and shortlived climate pollutant emission inventories as well as dynamic monitoring of key emission sources at high spatiotemporal granularity a stateoftheart modelling framework will be developed exploiting and advancing cuttingedge and established modelling tools for eu and china using the latest emissions data representing technology and policy options enabling assessment of socioeconomic impacts covering multiple economic sectors and regions and offering high spatial and technology detail the enhanced models will be used to coproduce netzero pathways for the eu and china explicitly assessing cobenefits and tradeoffs of climate policies with other societal goals while exploring cooperation policies and governance to drive the global transformation and assessing the distributional and globallevel implications of the two regions decarbonisation the pathways will be documented in new workspaces in the i2am paris platform
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the first economically viable process for phosphate recycling
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in the eu phosphorus p is listed as a critical raw material it is essential for life and there is no known substitute p is a vital constituent in fertilisers the eus agricultural need is 39 mtyr we import 90 of what we consume and 90 of what we use is irreversibly lost the susphos solution upcycles prich waste like sewage sludge ash ssa or struvite into phosphates iron magnesium salts and silica mixtures our highquality pathogenfree compounds are suitable for formulating fertilisers and phosphatebased flame retardants fr reaction byproducts are finechemicals in their own right making our technology a nearzero waste process currently there is no technology except ours that can upcycle ssa for direct use by fr or fertiliser manufacturers competing solutions for p recycling are costprohibitive they all use water as a solvent which means high energy requirements for solvent evaporation our patented solution uses merely waste heat which allows us to price our phosphates on the same level as if they were derived from mined phosphate rockwe will create an independent eu supply of recycled p reducing the eus dependence on supply and price volatility by 2026 we project revenues of 33m and a 20 displacement of conventionally produced phosphates our circular p will eliminate co2 from rock phosphate transport and reduce pollution caused by mining our urban mines susphos plants will create hundreds of jobs across the eu and at susphos we are striving to strengthen female leadership and inspire women to choose to conduct their higher education and build carriers in chemical engineering and raw materials currently very maledominated sectors with the support of women techeu we aim to upgrade our rollout plan and sharpen our business development skills so that we can grow large enough to become a leading technology provider for circular p and to become and influential player in deeptech innovation ecosystem
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