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governance and business models for living labs rural regeneration hubs for tackling soil health challenges in the mediterranean region
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in the eu 6070 of soils are degraded as a direct result of unsustainable management however tackling this multifaceted challenge is not an easy task mainly because farmers decisions are influenced by a wide range of factors making it difficult to define regenerative soil management practices that are simultaneously effective economical have demonstrable yield benefits and are easy to implement in this context the goal is to foster a collective awareness at the the level of five mediterranean regions that soils and humans must be understood as socialecological systems and that no organisationsolution alone is capable of sustainably transforming the system the desired change can only emerge when the innovation process is supported by an exploration phase enabling actors to identify their personal from individuals to organisations drivers ultimately aligning purposes and behaviours toward impactful collective actions to demonstrate this the project will apply cocreation tools to multiactor governance structures emphasising the building up of a shared awareness of soil threats over the identification of specific technologies the main objectives of the proposed plan are 1 to explore regional needs and drivers and to validate governance models for operating multiactor cocreation processes 2 to establish a network of five agroinnovation hubs sustained by underlying business models 3 to define harmonised regional baselines for 7 out of the 8 indicators found in the soil mission implementation plan 4 to kickstart the multiactor codesign and validation of solutions for soil health that are practical and scalable 5 to facilitate the diffusion of innovation through a plethora of communication and dissemination actions gov4all concentrates on 3 mediterranean pedoclimatic zones where the hubs will serve as sustainable innovation centres aiding the soil missions objectives and inspiring soil regeneration regionally and beyond
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change impact analysis root cause analysis and aibased repair for safe and secure software evolution
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software is the driving force of todays world used in almost any system it has a wideranging impact on every area of private and public life from health to finance education entertainment business and governmentdeveloping software is a cognitively demanding task coming up with a software solution for a problem is already challenging and continuous changes in requirements and in the environment where software is used make it even harder as a result bugs and security vulnerabilities are often introduced during software development to make things worse even when these issues are discovered and reported many of them remain unfixed due to a lack of developer timegenerative ai promises to change the game by being able to automatically repair code but requires developers to validate that the proposed software fixes correctly address the issues while simultaneously checking that they do not introduce unintended behaviourforte combines automated changeimpact analysis with automated root cause analysis and aibased repair to enable an aiaugmented process of developing software our goal with forte is to help developers confidently change software without breaking it in unexpected ways and embrace generative ai to simplify the process of writing and fixing code to demonstrate the usefulness of forte we plan to use it with realworld software that is publicly available
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metamaterials for thermoelectric applications multiscale structure chemistry thermal property relations to uncover the local behavior of grain boundaries
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a major barrier to a wider adoption of renewable energy technologies is developing more performing materials grain boundaries gbs emerge having a strong and multifaceted impact on thermal and electrical transport critically controlling the materials performance in applications spanning from photovoltaics solid oxide fuelcells thermal barriers and thermoelectrics despite the considerable technological relevance our understanding of how the structure and chemistry of gbs govern heat transport at the local scale where gbs operate remains limitedmetasct is a career development program designed for dr eleonora isotta aimed at developing structure chemistry thermal property sct relations to advance our understanding of gbs to successfully deliver the project goals dr isotta will receive advanced research training from an intercontinental collaboration of worldleading institutes and will benefit of their cuttingedge expertise and equipment this opportunity will support dr isottas growth as independent researcher and expert materials scientist with lasting impact on her longterm career trajectoryif successful the project will uncover new knowledge on heat transport at gbs consolidate a promising material for thermoelectrics establish novel techniques for sct relations with 20x higher spatial resolution than current possibilities and develop predictive models high resolution techniques can have significant impact on broad areas of applied materials science and energy generation new understanding on gbs will enable the design of metamaterials with engineered gbs for several applications including thermoelectric energy harvesting and heat management
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impact and capacity assessment framework for uspace societal acceptance
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imafusa focuses on quantifying a variety of understudied factors influencing societal acceptance of uam in urban periurban and interurban areas especially when these are deployed using u3 and u4 services we aim to deliver an impact and capacity assessment framework for uspace societal acceptance imafusa to assist local authorities and other uspace stakeholders and users with the delivery of socially acceptable and beneficial uam deployment in cities the framework and its tools will provide insights in 3 major areas influencing societal acceptance environmental impact including noise visual pollution and air quality safety and socioeconomic impact including affordability accessibility economic development public space use and connectivity in each area innovative performance indicators will be described while mathematical formulas and algorithms will be developed to quantify them data on citizen noise perceptions perceptions on visual pollution safety perceptions and overall uam acceptance will be collected during 3 immersive citizen experiences of uam applications in the city of athens greece the usability of the developed indicators will be tested in a simulation environment simulating real future use cases with a varying volume and configuration of movements in uspace through the collaboration of the partners and the advisory board imafusa facilitates the flow and cocreation of knowledge and 10 innovative tools between higher education hei innovative smes local authorities and national aviation authorities imafusas developments benefit a variety of stakeholders including local authorities policymakers uspace service providers atmutm planners and operators drone manufacturers environmental agencies and citizens above all
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ammonia based membrane reactor for green hydrogen production
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while many hardtoabate sectors would benefit from a wide availability of green ammonia in europe the development of ammonia cracking technologies remains a prerequisite to unlock the full potential of ammonia as a hydrogen carrier andreahs main objective is to provide a quantum leap in the development of advanced ammonia decomposition technologies to produce ultrapure hydrogen 99998 by developing an innovative system based on a catalytic membrane reactor cmr for the cracking of ammonia in this way optimised heat management improved conversion per pass and purificationrecycling for more costefficient and resourceeffective ammonia decomposition at lower temperatures 400450c compared to conventional systems resulting in a decrease of capex and opex of the system that will bring the decentralized cost of h2 from 551 eurokg to 427 eurokg with a decrease of 225 for this purpose environmentally friendy and with less crms 8090 less compared to conventional packed bed systems structured catalyts will be developed and scaled up and integrated with advanced h2 selective carbon molecular sieve membranes and coupled with a sorbentbased hydrogen polishing step for fuel cell grade moreover the complete system will be validated at trl5 at the facilities of vtti in the port of rotterdam finally a complete lca lcc and hsa will be performed over the entire value chain of andreah appart from the different exploitable results of the project the ambition of andreah is to create a spinoff company that can exploit the advanced ammonia cracking system kic innoenergy supported more than 480 cleantech startups in the last decades and will provide support and advice to launch and boost the new spinoff
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duallayer coatings for iron and steel corrosion protection
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corrosion undermines metal integrity resulting in significant environmental and economic damage exceeding 25 trillion the anticorrosion coating market was 348b in 2022 however anticorrosive coatings have three limitations 1 high costs 2 toxicity 3 limited effectiveness during my erc project we developed and patented a technology that uses a duallayer coating engineered at the molecular level to provide a highly stable coating on iron to mitigate corrosion formation the system consists of a primer monolayer of nheterocyclic carbenes nhc molecules that is strongly anchored to the metal and a top layer of a tailored polymer network chemically linked to the nhc monolayer the duallayer coating yields superior corrosion resistance up to 995 effectiveness with no toxicity effect and can be produced and delivered at low costs this project aim is to assist us in creating a spinoff company serving several market sectors eg oil and gas marine construction aerospace etc however these sectors represent conservative industries which require rigorous proof and client education of the added value provided by our duallayer nhcpolymer coating hence the project will include requirements capture from potential partners and endusers for the design of thorough performance testing versus available solutions beyond testing the technological process of the project will include development of i optimized dual layer coating formulation on iron and steel and ii spraybased procedures for onsite coating the anticipated outcome is a scalable commercially viable technology with a minimum protection efficiency of over 95 after 1000 hours of aging in corrosive media this innovation holds significant potential for reducing maintenance costs and extending the lifespan of iron and steel across several industries
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recycling of low value components using high purity pretreatment direct recycling and green hydrometallurgical approaches for recycling of lithium ion and sodium ion batteries
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revitalise delivers a holistic solution for green lowcost and low environmental impact recycling of nmc hini lfp and naion batteries representing 85 of battery waste streams up to 2025 revitalise develops lowcost and green processes to recover a full range of battery materials including nmc lfp al cu li graphite fluorides phosphates and plasticsoverall recycling rates of 91 will be proven at trl4 for waste processed from postproduction scrap and endoflife battery black mass revitalise will develop innovative pretreatment technologies based on electrohydraulic fragmentation ultrasonication and magnetic and electrostatic separation that will achieve very high levels of material stream purity this will enable commercially viable recycling of lowvalue parts the approach will enable direct recycling of 40 of the cathode and anode active parts with direct characterisation of the lithiation or sodiation being developed that will be used as a basis of a smartreformation approach for reclaimed active materials the remaining 60 being suitable for hydrometallurgical recycling based on leaching with green organic acids from food waste such as vitamin c ascorbates vinegar acetate and citric acid citrates and inorganic acids produced from industrial wastesa further innovation is the development of water remediation with li recovery from all wastewater streams generated through the implementation of polymeric nanocomposite membrane separation with direct li recycling for li in water concentrations down to 06mglthe recycled parts will be assessed for closedloop battery and other secondary applications for precursors and semiproducts by industrial partners verkor and hydro through reformulation and upcycling of battery materials and validation of remanufactured batteries an optimised process flow will be determined to achieve commercially viable recycling with maximised recovery rates and minimal environmental impact
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children as agents of cultural evolution
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cultural evolutionary theory is quickly gaining traction as a unifying framework for the social sciences however research into culture acquisition paints a picture of children as vessels for inheriting evolved culture from adults rather than cultural producers in their own right chace aims to overturn this longestablished orthodoxy by taking child and adolescent peer cultures as a focal point neglected by cultural evolutionary theorists peer cultures are incredibly well conserved across generations despite threats to social transmission inexistent in adult cultures challenging our understanding of how cultures are maintained and changed across generations by intensively studying childrens peer cultures chace thus stands to discover novel causal mechanisms for cultural evolution chace specifically advances two groundbreaking hypotheses built upon firm theoretical and empirical foundations in folklore cultural evolution human life history and cognitive development 1 peer cultures evidence distinct cultural evolutionary mechanisms from adult cultures 2 knowledge produced as part of peer cultures helps communities adapt to social and ecological change chace will develop a robust and transferable methodology to jumpstart the study of peer cultures reflecting bestpractice workflows for causal analysis chace will first build ethnographically informed agentbased models to derive testable and falsifiable predictions these will be empirically evaluated via experiments observations surveys and interviews with children and adolescents aged 416 years and their caregivers at four globally representative field sites undergoing rapid culture change the likouala republic of the congo the omo valley ethiopia toledo belize and county durham uk in doing so chace will initiate a disciplinary course correction by driving forward an explicit and holistic account of childrens adaptive contributions to culture change
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multifunctionalization of wood with biobased approach multiwood
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wood is recognized as an attractive alternative to several traditional building solutions and it is often called a building material of the 21st century since it can efficiently sequester carbon balancing emissions from other materials as a biological material wood is sensitive to environmental conditions and microorganisms therefore it requires protective measures to extend its service life in outdoor applications despite the current demand for improvement of wood performance and considering technologies with low environmental impact there is limited research on treatments and formulations that use green alternatives and improve critical properties simultaneouslythe ambition of the multiwood project is to provide multifunctional treatments to entirely protect wood from nano to microscale using alternative sources of chemicals generated during the lignocellulosic bioconversion andor from the pulp and paper industries the project aims to develop innovative strategies for the improvement of four key wood properties hygroscopicity resistance against fire uv and biotic factors based on alternative recently underutilized biobased formulations proposed methodology and treatments target reduction in the toxicity of the modification processes extend service life elongate maintenance cycles and thus lower the negative impact on the environment the multiwood project will stimulate innovation and knowledge transfer between the host and er by building a solid research and industrial network organizing events mentoring young researchers and managing projects the er will gain research and scientific skills and acquire a new set of competencies to reach professional maturity and independence after the fellowship
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towards unravelling selfassemblydisassembly mechanisms of photoswitchable supramolecular gels by superresolution microscopy and their use for drug crystallization
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the overarching scientific goal of the lightsupgel study is to design and synthetize novel reversible photoswitchable azobenzene and bisureabased supramolecular gels and to develop a superresolution microscopybased methodology to visualize the selfassembly and disassembly process in realtime with the aim of unravelling their underlying mechanisms the cuttingedge combination of superresolution sted and flim microscopies together with environmentsensitive fluorescent probes will be employed to spatially controlled photoswitch the gelation and degelation and for first time simultaneously monitor the process with nanoscopic resolution furthermore the application of this new knowledge and novel photoswitchable gels in gelmediated drug crystallization will be explored the possibility of lighttriggered drug crystal harvesting photoswitchable gels offers will be the first ever described noninvasive and reversible method to harvest crystals from gels this new technology will mean a huge advance in the field of gelphase drug crystallization bringing it closer to its industrialization by completing this ambitious multidisciplinary work the applicant will be in an excellent position to create crossdisciplinary collaborations with research groups and industry across europe and to becoming an independent researcher himself
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improved carbon cycle representation through multiscale models and earth observation for terrestrial ecosystems
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earth system models esm show diverging estimates of ecosystem carbon c uptake which drives persistent uncertainty about future climate and limits the realization of policy mitigation goals the concerto project aims to strengthen the european research ecosystem by creating an innovative scientific collaborative framework that enhances our understanding monitoring and modelling of the terrestrial cycle cc and leads to reduced uncertainty and esm convergence this framework has three main elements the exploitation of novel earth observation eo data the innovation of process models fed by these data and data assimilation da and machine learning ml techniques the consortium includes european experts and institutes active in these areasconcerto will advance the representation of land cover leaf area index lai and management intensity through new maps of high resolution with layers relevant for the cc the new management map will enhance the creation of a new biomass production map further concerto will prepare for the ingestion of flex data in land surface models lsm through da and exploit sentinel5ptropomi hcho indicative of biogenic volatile organic compound voc emissions as step towards moving away from prior static parameterizations the novel p model will be used to ingest these new data sources this will enhance understanding of ecosystems responses to climate extremes fires and vegetation recovery from them and the parameterization of lsms included in esms novel representations of the underrepresented processes of lateral carbon fluxes through outgassing of co2 from rivers will be developed dedicated seasonal and climate experiments will demonstrate how improved representation of land surface processes benefit the accuracy and trustworthiness of global earth system simulation this will lead to better predictability of the influence of land management on the cc and underpin avenues towards carbon neutrality
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design and catalytic applications of photoactivated frustrated lewis pairs
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in 2006 douglas stephan described the first reversible metalfree hydrogen activation via frustrated lewis pairs flps in these pairs the presence of bulky substituents in both the lewis acid and base precludes the formation of the lewis pair creating a highly polarised pocket that can activate small and organic molecules although mostly of the flps seem to react via two electron processes a few flps have shown radical reactivity namely frustrated radical pair frp this radical reactivity has been already used in synthetic applications of interest like cc bond formation however there are very limited of examples of main group frps which formation depend entirely of the nature of the substituents of the lewis acid and base another interesting type of flps are those in which either the la or the lb is constituted by a transition metal tm which eases the possibility of catalytic applications due to the high versatility and reactivity of tms regarding transition metal only flp tmoflps the first example was described recently by the group of jesus campos constituted by aupt as lb and la and lb respectively this pairs have shown activity in the activation of small molecules like hydrogen or acetylene in this project the family of known mg frps will be extended with the rational design of a family of photoactivated frps this novel frps will be then tested in the activation of small molecules and co bond activation reactions following this approach a family of hybrid transition metalmain group photoactivated frps will be prepared and their reactivity will be tested both in small molecules activation and potential catalytic applications of interest such as ethereal co bond activation finally a family of photoactivated tmoflps will be prepared the family of known tmoflps will be extended to 1st row tms and the photoexcitation of these pairs will be explored for unprecedented catalytic applications
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robust causal discovery
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robust causal discoverydue to technological advances the available amount of data has increased tremendously over the last decade the fields of data science statistics computer science and econometrics have followed this growth as they provide indispensable tools for translating data into insights and knowledge where data science was traditionally concerned with learning associations in data it has recently become clear that causal relations often provide a deeper understanding and a stronger tool in many practical applications this has led to the flourishing of causal inference with some of the most prestigious scientific awards going to pioneers in the field over the last decade can we learn causal mechanisms from observational data is one of the compelling questions that is occupying scientists all over the world where it was originally answered by skepticism it has become clear that we are not completely powerless and there are indeed ways to infer causal structure from observational data under the right conditions however all of the current methods assume that the observed data perfectly follows the underlying causal structure unfortunately real world data is often contaminated by anomalies and measurement errors violating this assumption and thus weakening the reliability of methods for causal discovery this proposal aims to fill this gap by developing methods for causal discovery that remain efficient and reliable under data contamination in particular it i builds a theoretical framework for robust causal discovery ii develops methods for causal discovery that are provably robust and correctly identify the causal structure and iii investigates the effect of contamination on realworld discovery tasks as a result in addition to advancing the theoretical understanding of causal discovery this proposal builds a versatile toolbox to support scientists doing causal discovery and improve the reliability of their findings
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the oval study for vb111 treatment of platinumresistant ovarian cancer
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vbl therapeutics is a latestage clinical biopharmaceutical company focused on first in class treatments for cancer vbls lead oncology product candidate vb111 is an innovative targeted anticancer gene therapy with potential to treat a wide range of solid tumors most cancer therapies aim to target tumors cells while sparing normal cells but tumors are heterogeneous and often develop resistance to treatment instead of targeting the tumor directly vb111 targets the tumor environment by disrupting the blood vessels that supply blood to the tumor and by recruiting the immune system into the tumor this dual mechanism of action together with an excellent safety profile make vb111 a gamechanger vbl is pursuing ovarian cancer as the first indication for vb111 in the scope of this project vbl will to finalize a phase 3 potentialregistration clinical trial the oval study as well as execute all the necessary steps towards final regulatory approvals and commercialization
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investigating the contribution of the sensory visual cortex for representation and storage during visual working memory
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visual working memory vwm is the cognitive process responsible for temporarily maintaining in mind visual information that is no longer in view the neural architecture of vwm has been of continuous scientific interest and it has been proposed that the sensory visual cortex is involved in the brain network responsible for successful representation storage during vwm however the contribution of the sensory visual cortex in vwm remains a subject of intense debate underscoring the need for a decisive investigation restore aims to shed light on this debate through a threeway transfer of knowledge restore will lead to contemporary methodology by combining transcranial magnetic stimulation tms with electroencephalography eeg resulting in a robust and costeffective approach for studying vwm by combining tms with eeg restore will surmount the limitations of previous work eg the correlational nature of brainimaging studies the lack of evidence for neural activity in brainstimulation studies and thus result in causal evidence for the role of the sensory visual cortex during vwm this scientific leap will not only resolve a longstanding controversy but also introduce an efficient approach for conducting neuroscientific research hence contributing to the literature and advancing the current stateoftheart in addition restore will enhance the expertise repertoire of the researcher and the participating organisations in turn this will establish a strong foundation for pursuing ambitious and innovative research in the future as well as provide knowledge and skills for training future researchers in contemporary research restores innovative integration of tms and eeg aims to decisively illuminate the longstanding debate about the role of the sensory visual cortex in vwm and lays a solid groundwork for future ambitious investigations while fostering expertise and knowledge transfer for the next generation of researchers
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modular heating technology through renewable resources for steel production
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nowadays the overall energy demand in downstream steel production is mainly based on fossil fuel so it is fundamental to find and set new ways to overcome the environmental impact of steel productioncurrently the stateofart of reheating furnaces is based on ch4 burners with an evident environmental impact on co2 emissionsthe main objective is to decarbonize this process based on the introduction of hybrid heating technology based on electrification and gasburning properly combined this solution provides an opportunity to explore the synergic effect of different technologies by hybrid heating moreover the whole efficiency of the heating process can be furtherly improved by the recovery of enthalpy content of offgases from the furnace the furnace partial electrification will be realized by the installation of an induction system the electricity to feed the inductor will be provided by a renewable source res and by the heat recovery system
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a mechanismbased approach to the prevention of chronic pain and its comorbid mental disorders
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chronic pain is a major health problem typically associated with mental disorders such as depression or anxiety and is still difficult to treat despite enormous efforts in the biomedical community this project proposes a radical shift from the symptomatic focus on chronic pain and predefined diagnostic categories to a mechanistic analysis and treatment of psychobiological factors that shape the transition to chronic pain and its associated mental diorders in a transdiagnostic approach the proposal aims to identify transdiagnostic mechanisms of the development of chronic pain across three major diagnostic subtypes of pain primary musculoskeletal pain neuropathic pain primary headache that are usually analyzed and treated in isolation and conducts a proof of principle study of mechanismbased modular digital and virtual realitybased interventions work package wp 1 will use metaanalyses to determine common and specific transdiagnostic mechanisms of chronicity across these three diverse pain disorders wp 2 will analyze longitudinal data from existing databases on pain development using machine learning and knowledge graph approaches wp 3 will develop an assessment battery for core psychobiological mechanisms and identify predictors of chronicity as well as comorbidity with mental disorder across diagnostic groups using advanced unsupervised learning algorithms wp 4 will devise easy to apply real life digital and virtual reality interventions that target core psychobiological processes wp 5 will contain a proof of principle study that contrasts standard cognitivebehavioral pain management with the mechanismbased intervention modules they will be applied in a digital format and contain virtual realitybased interventions statistical analyses will include linear mixed models an n1 design as well as a microrandomized trial we believe that this transdiagnostic mechanistic approach will make a major contribution to the prevention of chronic pain
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formose reactions on microdroplets from
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i propose to examine the importance of water microdroplets sprayed from geysers as a reaction medium in prebiotic chemistry with the goal of providing evidence for co2reduction to formaldehyde and following synthesis of carbohydrates from formaldehyde via the formose reaction water microdroplets have recently been proven to be a unique reaction medium but the importance of microdroplets for the origins of life remains largely unexplored this fellowship application proposes geysers as a catalyst for synthesis of complex organic molecules at the origin of life a new hypothesis which has previously not been explored this is a high risk high gain proposal and the new scientific skills obtained during the fellowship will be highly valuable for a research career at the interface of organic synthesis and microdroplet chemistry the project will be carried out over two years with prof michael pittelkow at the university of copenhagen where all synthetic chemistry kinetic experiments and characterization of products will be performed
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ondemand hydrogel microbeads mass production by inkjet bioprinting for stem cell largescale cultivation
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the aim of the stemstation project is to propose a novel strategy for human mesenchymal stem cells mscs cultivation and production allowing to overcome the current limitations faced by manufacturers to develop efficient and scalable processes to answer the market demand the main strategy is to exploit the inkjet bioprinting technology to manufacture mscsloaded microbeads of a hydrogel for cell expansion and production scaleup this strategy will allow the ondemand fabrication of cellloaded customized microbeads directly inside the bioreactor thus stemstation is proposing an allincluded production system for mscs with a clear objective of shortening the expansion steps in a scaleup process such methodological and technological innovation has the potential to be further transferred to other adherent cell bioproduction systems current largescale mscs production strategies are strongly focused on solid microcarrier cultivation where cells are adhered on their surface such microcarriers are then suspended in production tanks where standard cultivation protocols must be specifically optimized such technologies are commonly limited by the cell source the cellmicrocarrier interaction as well as the lack of an easy to handle robust transferable and scalable process stemstation targets to overcome problematics by offering an original and innovative production strategy which will bring novel scientific knowledge in the field of bioproduction stem cell growth inkjet bioprinting proliferative biomaterials and clinical grade transfer of largescale cultivation process of human mscs
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quantum tensor engine
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quantum computers harness fundamental aspects of quantum behavior to drive exponential increases in the speed with which certain computations can be performed they have potentially a tremendous longterm impact in areas such as quantummany body physics and material science and further afield in machine learning the quantum manybody problems studied by condensed matter physicists are perhaps the most likely to yield early demonstrations of this potential however current and nearterm intermediatescale quantum nisq devices are limited in the number of operations that they can carry out before their performance is degraded by interactions with the environment to take advantage of these platforms and to outperform classical computers highly efficient and specialized quantum algorithms are required the implementation and benchmarking of these basic algorithms on different quantum computing platforms is challenging and requires a detailed knowledge of the underlying physics our approach is to produce a readytouse highly innovative software package based upon quantum tensor networks the quantum tensor engine qtengine will provide a unifying framework for both quantum and classical algorithms the qtengine will serve as an engine to drive fast and easy implementation of quantum simulation quantum machine learning and optimization algorithms the anticipated user base include academic groups as well as commercial research and development groups
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deciphering snps involved in oligodendroglia functional resilience in multiple sclerosis
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multiple sclerosis ms is a prevalent demyelinating disease that primarily affects young adults current therapy for ms mainly focuses on immune suppression and alleviating inflammation however efforts to promote remyelination face challenges in clinical translation animal models of acute demyelination have demonstrated promising remyelination primarily facilitated by newly generated oligodendrocytes nevertheless the scenario in human ms differs as the disease typically manifests in adulthood and the progression of lesions occurs over several decades in the proposed project resilms by using barcode based lineage tracing combined with ultradepth singlecell and spatial transcriptomics i will identify the molecular profiles of existing and newly generated oligodendrocytes at different stages of a mouse model induced with experimental autoimmune encephalomyelitis eae the aim is to comprehend how an oligodendroglial cell pool diversifies its subpopulations during prolonged disease challenge and what are the unique molecular properties for resilient cells to maintain their ability to endure an adverse inflammatory environment and remyelinate further i will perform a screen of single nucleotide polymorphisms snps associated with risk and severity of ms that might affect genes related to the resilience of oligodendrocytes to experimentally explore the effect of relevant snps human oligodendrocyte cells holgs derived from pluripotent cells will be perturbed with crisprbased genetic modification and observed for cell profile and functional changesthe identified snps and resilience molecular pathways may play a critical role in disease progression for ms patients by delving into the mechanisms of resilience of remyelinating cells in a long disease course this project will provide valuable insights into msrelated genetic risk and protective factors and potentially advance diagnostic and therapeutic approaches in ms research
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anticounterfeiting solution based on integrated circuits implementing highentropy physical unclonable functions
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the entropic project aims to advance the technology and market maturity of a comprehensive anticounterfeiting and identity management solution based on proprietary silicon integrated circuits implementing highentropy physical unclonable functionsphysical unclonable functions pufs are silicon integrated circuits that leverage random variations in the fabrication process to implement a unique function that is unknown to the observer and the manufacturer and extremely difficult to determine experimentally from a behavioral viewpoint pufs are circuits that respond to digital input strings challenges with perfectly repeatable digital output strings responses where the challengeresponse mapping the unclonable function is fully repeatable with aging and with varying environmental conditions as of now the practical adoption of pufs has been restricted by their limited entropy which makes them vulnerable to cyber attacks eg bruteforce and aibased attacksentropic proposes innovative highentropy silicon pufs with worldrecord resilience to brute force aibased and sidechannel attacks the breakthrough entropic puf is a strong puf with at least 2 mbit of entropy thanks to mixed analogdigital chip design whereas pufs available in the market now are of the weak type and have maximum entropy of 4 kbitthe novelty of the highentropy pufs proposed in entropic enables us new applications and a different business model instead of selling chips or licensing ip we target a business model that provides a fully managed solution to an industrial customer that needs to defend its brand from counterfeiting or to deploy and manager secure internet of things devices
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trading chinese migrants networks of human trafficking in treatyport china 18301930s
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despite the excellent work of historians in the past three decades to provide a comprehensive history of the chinese coolie trade the trafficking of women and children remains still underrepresented this innovative project will use cuttingedge data technology to track for the first time the networks operating the trade in children women and male labourers in an integrative perspective it will trace how the private sector such as intermediaries and companies and the nations involved shaped the history of international forced migration in nineteenthcentury china relying on my supervisors technical expertise i will mobilize a wealth of quantifiable data accessible on international human transportation in the form of an openly available database to analyse and depict the systems connecting these various forms of bondage in the past four years as a postdoctoral researcher i have collected an outstanding amount of data from unpublished multilingual source material scattered in archives in europe asia and america during the mscapf i will undertake further research in cuba the uk france spain and germany to gather the sources needed to complete the datasets and to publish the results in a monograph and a journal article the data collection will convey a novel contribution to the existing database project exploring slave trade in asia esta an international collaboration by the international institute of social history in amsterdam the cole normale suprieure ens de lyon the bonn center for dependency and slavery studies bcdss and linnaeus university the database will be the structure for a future document preservation project to pursue in more advanced grants my training at the ens and the bcdss will strengthen my specialization as a sinologist integrate me in stateoftheart scholarship on asian bondage and equip me with the technical and academic abilities needed to boost my career prospects
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probing cosmic largescale structure beyond the average
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the cosmic largescale structure is entering a new full space era with the launch of the euclid galaxy survey satellite in 2023 coinciding with the first light for the rubin observatory my proposal is centred on using galaxy surveys across a third of the sky as a laboratory for fundamental physics beyond the standard model by combining powerful theoretical models with exquisite data for galaxy clustering and weak gravitational lensing to fully realise the potential of euclids full space galaxy survey i will use my unique expertise in developing analytical computational and statistical methods to predict and analyse the cosmic largescale structure beyond the averagei will hunt for fundamental physics by going beyond the average probed by standard twopoint analyses and unlocking additional information from novel clustering statistics sensitive to different density environments i will provide new insights into dark matter dynamics and enable a fieldbased analysis by pioneering a particlewave duality inspired phasespace technique that goes beyond the average effective fluid modelling this will push forward modelling to a new level overcome limitations of standard fluid and nbody methods and enable the joint modelling of dark matter baryons and massive neutrinos my research program will unlock key insights into particle physics by pinning down the total neutrino mass and potential wavelike properties of dark matter the early universe by constraining primordial nongaussianity providing hints for inflationary physics gravity by measuring the nature of dark energy and potential modifications of general relativity and astrophysics by determining the relationship between galaxies and dark matter my expertise in developing analytical computational and statistical methods for clustering dynamics and statistics and my leadership within the euclid collaboration places me in a strategic position to lead such an ambitious research program
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nitrate recovery capacity status
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nitrate pollution remains a significant concern for water quality since the 90s europe has been actively working to reduce nitrate levels and improve water quality yet restoring water quality is a slow process as nitrates may remain for decades within aquifers as a legacy while imperative assessing nitrate recovery capacity nrc faces challenges due to strong variabilities in nitrate transfer times and percentages removed by bacterial consumption within anoxic zones often requiring intricate models here we propose to leverage an innovative regionalscale assessment method to investigate the correlation between nrc and a readily accessible catchment attribute lithology comparing nitrate concentrations with proxies of conservatively transferred element nirecas determines the nitrate reactivity and legacy of a region within consistent geological contexts the method analyzes the correlation between these factors and lithology while providing uncertainties of the correlation estimates our objectives are to i investigate the control of lithology on nitrate reactivity and legacy using 200 pilot sites in the armorican massif france taken as a first experimental region and ii extend and generalize the methodology to other european regions our deliverables include 1 a methodology for regional scale nrc mapping using available lithology databases 2 maps of nrc for one to several european regions where lithology is found to be the primary controlling factor 3 a userfriendly interface to a priori assess the percentage and transfer time of nitrate removedthis should provide key information on the ability of vulnerable regions to restore water quality while catching the legacy of past agricultural practices at the relevant resolution besides nirecas should serve as a valuable predictive tool to assess the impact of current agricultural strategies on future generations and support the transition of practices over the medium and long term
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thermal and energy management for increased driving range of an electric minibus including improved usercentric design and thermal comfort
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minded addresses in full the expected outcome and scope of the horizoncl52023d50101 topic by delivering a battery electric iveco edaily minibus with 20 improved range at 0c against the 2023 baseline this is achieved by introducing a highly efficient heating system based on infrared ir panels controlled by a novel usercentric hmi embedding an optimised thermal and energy management strategy tems for improved comfort and reduced energy consumption these activities are complemented with the demonstration of a new hvac unit based on a heat pump capable of reducing the vehicles cooling energy requirements by 15 against the baseline while leveraging the efforts made on the hmi and tems to do so minded encompasses 10 technology bricks organised in three areas heating and cooling system area i including 1 ir heating panels 2 thermal cabin insulation 3 a thermal mannequin for evaluating passenger comfort 4 the optimised hvac unit featuring an ecompressor with gas bearings 5 the required ecus and 6 the usercentric hmi digital twin and control strategy area ii including 7 a new digital twin model 8 an aibased algorithm for predicting driving behaviour 9 the tems and 10 a comfort control strategy for determining optimal settings demonstration and performance evaluation area iii demonstrating the iveco edaily minibus on the dynamometer at trl7 and the hvac unit on the thermolab testbed at trl6beyond the range improvement minded demonstrates a cost reduction of 5 at vehicle level from simplified systems installation and reduced battery requirements and a development time reduction of 30 achieved using the digital twin model and ai the project generates its primary impact in the bus and minibus vehicle segments with the minded technology bricks expected to equip 75 of the iveco bus fleet by 2035 while delivering technologies exploitable in the mediumheavy commercial electric vehicles market
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foundations for sustainable security
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security and efficiency are often seen as a conflict it already consumes 11 of electricity globally with a steep upwards trend resource sharing increases efficiency but introduces information leakage vulnerabilities such as meltdown and spectre reducing reliability margins also increases efficiency but introduces fault attacks such as rowhammer and plundervolt this reveals a fundamental problem in current systems reliability mechanisms are not designed with adversaries in mind security is then patched on top of reliability mechanisms incurring additional energy costswe will overcome the conflict between security and efficiency with novel foundations to make security sustainable and use security to increase efficiency we will research how to measure the efficiency of security design principled and efficient security mechanisms utilize security to increase efficiency secure microarchitectural optimizations and secure lightweight isolationour methodology is to integrate principled cryptographygrade security into all system layers to minimize and supersede inefficient reliability mechanisms we will develop a framework for finegrained energy efficiency measurements we will research finegrained replication for sidechannel isolation maintaining efficiency we will explore selective resource sharing for secure variables enclaves and virtual machines superseding todays inefficient and insecure techniquesthe originality of fssec stands out in that energy efficiency has played no role in security so far in particular using cryptography to replace established error correction methods will be the key to our goal of using security to increase efficiency by 20 compared to current systems we will construct secure optimizations with finegrained isolation increasing the efficiency without adding side channelsasstprof daniel gruss heads an internationally renowned security research group fssec will fund 6 phd students
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fostering circularity in textile innovative interoperable solutions and best practices for implementation and harmonization of epr schemes
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circulatex with its multidisciplinary approach aims to support the eu strategy for sustainable and circular textiles by facilitating the redesign of textile value chains through the adoption of a circular approach and ensuring compliance with the expectations of extended producer responsibility epr schemes and european directives the project will delve into the failures and gaps in the current textile value chain particularly in terms of technological environmental economic legal and social aspects and will explore the effectiveness of epr schemes and other technological and nontechnological measures to maximize the sustainability of the textile sector the project will employ cocreation approaches to engage all stakeholders in the value chain and relevant case studies to develop actionable recommendations for circular textile management these recommendations will include solutions to enhance the scalability of textile recycling and reuse through ecodesign strategies efficient systems for material composition identification and labeling to support textile collection and sorting as well as traceability of information and innovative approaches for reuse and waste treatment circulatex aims to provide evidencebased criteria for the harmonized implementation of epr schemes and associated policies across the member states an innovative labeling system in line with the digital product passport and ecodesign for sustainable products regulation directiveespr will be developed to provide consumers waste collectors and reuserecycling organizations with valuable practical information and promote reuse and the uptake of secondary materials in the market the findings initially applied and validated across four case studies are expected to be expanded and replicated in various textile market segments and eu countries
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codasip highend processor ip and highlevel design tools for riscv
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codasip offers a unique combination of semiconductor processor ip based on the riscv open instruction set architecture isa and highlevel eda tool codasip studio providing outstanding flexibility and 5x faster time to market riscv isa can be used for a wide variety of applications ranging from low power and low gate count embedded cores to advanced high frequency application cores we are extending our portfolio of ip cores to include highend highperformance compute area complementing our cores that cover the power efficient embedded and mid range compute area a new generation of advanced core with a 9stage pipeline with outof order superscalar architecture called a90 the release of a90 will lead towards the a110 core with heavily speculative execution and an 11stage pipeline the design of these cores will simultaneously trigger a release of codasip studio processor design tool for highend compute including advanced features like support of out of order architectures
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stretchable microorganic electrochemical transistors circuits for neural interfacing
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this project is aimed at developing active soft neural probes for highresolution highdensity interfacing of the peripheral nervous system pns the availability of highresolution pns interfaces is key to the treatment and management of a number of common medical conditions such as neuropathic and chronic pain paralysis major depression and epilepsy two major challenges that hinder progress in this area are i mechanical mismatch between the neural tissue and the conventionally used neural probe materials eg metal wires ii the electrode density and spreading is limited by the use of passive linear probes this project seeks to address both these issues by developing miniaturized inert ultrasoft e50kpa multiheaded probes which can be actuated in situ to record from a large volume of the neural tissue with high spatial resolution this is combined with integration of multiple active neural transducer elements and integrated amplification circuitry for high signal fidelity and integrated multiplexing circuitry for addressing into each probe arm this approach simultaneously increases spatial resolution and signal fidelity of neural interfacing while enabling chronic implantability due to decreased chronic immune response and scarring through the inert and mechanically compliant nature of the probes as well as minimized tissue damage during implantation
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tool to ensure safe digital lives for kids and teenagers
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aiba creates safe digital lives for kids and teenagers we do realtime detection of fake profiles and unwanted behavior such as cyber grooming toxicity harassment and bullying in games and social media our machine learning powered moderation service will make moderation easier for our customers we risk score all ongoing conversations realtime on gaming and social media platforms and help our customers to prevent unwanted behavior before it makes any harm we help them stop cyber grooming early and our initial results show we can detect grooming coversations in less than 20 messages our service is powering our customers with increased community health and more efficient moderation through proactive and continuous risk scoring they can save huge amounts of human hours by using our solution our unique saas multimodal approach combined with machine learning makes for a new era in chatroom moderationwith a novel approach based on awardwinning research researchers and data scientists at aiba and ntnu have developed and trained machine learning models with text and keystroke dynamics to detect cyber grooming and other unwanted behavior early so they can stop conversations to minimize harm and toxicity on their platforms the solution has been trained and tested on short texts typically sent in a chat from this minimal amount of information the system has accurately been able to profile the chatter and determine both their age group and gender the solution has been further developed to perform a continuous realtime analysis of the text messages to mark suspicious conversations to do this natural language processing features turning text into numerical feature vectors are used in combination with machine learning techniques
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unravelling the mechanisms for recruitment and activation of septal peptidoglycan hydrolases in staphylococcus aureus
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peptidoglycan pg hydrolases are instrumental in mediating bacterial daughter cell separation via septum splitting an essential process for the ability of bacteria to multiply in a grampositive pathogen such as staphylococcus aureus the division septum is completed before pg hydrolases initiate septum splitting s aureus is an important pathogen as it is one of the most common causes of death by antibiotic resistant infections premature splitting of the division septum could expose an immature bacterial cell surface devoid of virulence factors leading to pathogen elimination by the innate immune system of an infected host hence the activity of pg hydrolases must be tightly regulated to avoid deleterious effects on bacteria including lysisinducing breaches in the cell surface that would lead to bacterial death s aureus encodes 19 pg hydrolases most of which have illcharacterized functions and regulation mechanisms in this project i will identify the complete set of pg hydrolases that have a role in septum splitting uncover their mechanisms of localization to the division septum and identify how they are regulated during the cell cycle and particularly what triggers their activation to initiate septum splitting at the right timing for this i will join the laboratory of prof mariana pinho itqb universidade nova de lisboa due to their unmatchable expertise in the field of staphylococcal cell wall biology and their commitment to promote my career development during the mscapf project this fellowship is a unique opportunity to develop my research and complementary skills acting as a critical steppingstone towards a tenuretrack faculty position
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investigating transcutaneous auricular vagus nerve stimulation as a strategy to prevent cognitive aging tackling 3 basic questions
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the number of people with alzheimers disorder ad and other dementia is expected to triple worldwide by 2050 to tackle the global burden of ad the european parliament acknowledges and points to the urgent need to develop interventions that can prevent or delay ad the locus coeruleus lc in the brainstem plays a key role in determining latelife cognitive decline and is considered a promising therapeutic target to prevent ad transcutaneous auricular vagus nerve stimulation tavns is a neuromodulation tool hypothesized to increase lc activity and in turn prevent cognitive aging evidence for an effect of tavns on the lc is mixed which undermines the discovery of tavns as a preventive strategy for ad the current project aims to reveal whether tavns increases lc activity in young and older adults to this end i will address 3 research questions first do short bursts of tavns increase lc activity in a parametricdependent manner in both young and older adults second does the effect of tavns on lc activity depend on the individuals background arousal state third does a short tavns intervention improve a cognitive function that relies on lc activity addressing these questions is key to learn how to effectively activate the lc through tavns and validate the mechanism through which tavns may prevent ad the project adopts a novel interdisciplinary approach integrating knowledge from psychophysiology subfield respiratory psychophysiology gerontology cognitive neuroscience of aging and neurostimulation tavns as a tavns and lc expert i am particularly suited to successfully conduct the project the fellowship will provide an exceptional chance to expand my expertise and receive topquality training from internationally established experts in the fields of cognitive neuroscience of aging and respiratory psychophysiology it will also allow me to establish my independent research line develop my career and expand my scientific network
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the molecular basis of conductive and vascular tissue development in plants
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plants contribute up to 80 of all biomass on earth despite their staggering diversity dominant land plants share a highly important characteristic the presence of a vascular system providing physical support and long distance transport this is however not a simple binary trait as some nonvascular mosses contain cells with conductive capacity resembling that of vascular plants available evidence indeed suggests that conductive tissues of nonvascular plants are functionally homologous to vascular tissues in vascular plants and can even be compared at a molecular level however the molecular players involved in conductive tissue development remain almost completely unknown moreover although key molecular regulators of vascular tissue development have been identified in the model plant arabidopsis very few are shown to be functionally conserved across vascular plants despite their importance for growth and development we thus have a limited understanding of the evolutionary conserved regulators of plant plumbing systemsin pipelines i will consolidate my expertise in singlecell applications and build a dedicated team to identify conserved molecular players specific to vascular and conductive tissues by combining multispecies comparative singlecell and spatial transcriptomics with gene regulatory network inference and characterize these factors using lossoffunction approaches by comparing this data i will determine the ancestral set of regulators sufficient to trigger specification and differentiation events in plants and validate these through introduction of singlecell sample multiplexing in a heterologous systemby unravelling the molecular basis of vascular and conductive tissue development and identifying conserved core developmental regulators the output of pipelines will act as a starting point for targeted engineering of vascular tissues which holds great potential for improving plant biomass and productivity in crop species
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algorithms and game comonads
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our modern society is driven by computers digital services and algorithms understanding their weaknesses and limitations is one of the main subjects of study of theoretical computer science probably the most studied aspect of algorithms is their efficiency of use of computational resources embodied as the running time of an algorithm parameterised complexity is a branch of theoretical computer science interested in determining whether there exists an efficient algorithm that solves a given computational problem the efficiency is determined based on the structure of the input datathe main limitation of parameterised complexity is that these analyses of computational problems are done on a casebycase basis this means that if somebody changes the problem or its parameterisation ever so slightly the whole analysis has to be redone from scratchto tackle this problem we propose to use game comonads a novel structural approach to logic in computer science the theory of game comonads draws its strength from category theory a wellestablished discipline of mathematics which specialises on compositionality reusability of its tools and highlevel of abstraction game comonads despite being relatively new have already shown to be a useful tool in the study of finite model theory which is an adjacent area of study of parameterised complexitythe primary goal of this project is to bring compositional tools of category theory into the setting of algorithms with game comonads acting as the connecting glue this project bring together expertise in category theory in the form of the applicant and expertise in parameterised complexity in the form of the host institution and the supervisor who will devote their efforts into bridging the gap between the two thusfar mostly disjoint disciplines of computer science and mathematics
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finding exoearths tackling the challenges of stellar activity
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fierce aims at providing the longneeded step forward to tackle the challenges of stellar activity on the search for exoearthsthe detection and characterisation of other earths planets with the physical conditions to hold liquid water and thus potential lifesustaining environments is a bold objective of present day astrophysics this goal continuously pushes the development of new ground and spacebased instrumentation however the quest for other earths is severely limited by astrophysical noise from the host stars whose signatures distort the spectra that are used to detect and characterise them existing methods usually circumvent the problem without a detailed understanding of the individual sources of variability this is insufficient to reach the required precision levels to enable the full scientific success of major exoplanet research facilities a new approach is clearly neededwith fierce the pi will employ his competitive team together with the strong participation in cuttingedge eso and esa projects and missions to break through in this obstacle the ultimate goal is to i develop novel approaches to identify model and correct stellar spurious signals in radial velocity measurements down to 10 cms and ii obtain a comprehensive understanding of the impact of stellar granulation and activity on the detection of exoplanet atmospheresto this end fierce will approach the problem of stellar noise from a whole new angle building a dedicated facility the paranal solar espresso telescope poet poet will connect to the recently commissioned espresso spectrograph and using the sun as a proxy allow to unambiguously identify and understand the sources of relevant variability in solartype starsambitious timely and feasible this project will provide crucial information for the success of present and future major efforts aiming at detecting and characterising other earths
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agrobiogel international scaleup
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agrobiogel is a novel soil improver that stores and slowly releases water and fertilizer it addresses many of the pain points and challenges of modern farming forestry plant nurseries and green houses all over the world1save up to 40 irrigation water2protect plantscrops from increasing droughts and erratic rainfall patterns3reduce agricultural input costs4convert agricultural non productive soils including 100 sand soil into agriculture productive soils5matching the urgent desire to replace expensive non biodegradable fossil based hydrogels with much cheaper organic hydrogels6agrobiogel as a product of widely underutilised lignin produced by the pulp and paper industry as well as the emerging biorefinery helps create value for this raw material thereby helping them not only expand their product portfolio but also reduce their carbon footprint and greenhouse gas emissions
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soft actuators for wearables exoskeletons and augmenting robotics
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softwear will create a highly interdisciplinary dn in the emerging and rapidly growing field of wearables with a unique focus on soft actuators for wearables and exoskeletons the primary objective of softwear is to train young researchers in the multidisciplinary science of soft actuators for integration in wearables and augmenting textiles this will be achieved by merging chemistry physics mechanics electronics textile technology design humantechnology interaction and ethics in a truly interdisciplinary manner while teaching essential skills in ethics product development ipr and industrial realisation thus providing a unique added value to the careers of the researchers this ambitious aim will be accomplished by onthejob training on innovative research projects developing beyondthestateoftheart soft actuator technology and integrating this into active garments and soft exoskeletons this will be carried out at leading academic groups and by immersion in applied projects at the industrial partners softwear will thus provide europe with highly educated researchers in the emerging field of wearables focused on integrating actuation this will put europe in a worldleading position in this field and will supply european companies with a highly skilled workforce in soft actuators and advanced smart textiles
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dismantling redialing personalizing and implementing task shifting psychosocial interventions to treat and prevent common mental disorders in lowresource settings
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reshift focuses on preventing and treating common mental disorders in people living in lowresource settings it aims at a dismantling psychosocial interventions delivered by non specialist providers into their components b evaluating each component efficacy and redialing the most effective components into a novel task shifting psychosocial intervention and c implementing findings through a worldwide coverage elearning platform reshift will also develop a publicly available calculator to estimate the efficacy of each component based on individual participant characteristics starting from an analysis of individual participant data from all randomized controlled trials conducted in the field of global mental health available on the matter reshift will pioneer a sophisticated study design to unravel which components work best and for whom identifying at the same time how participant provider and delivery characteristics moderate the outcome and how beneficial effects of the psychosocial task shifting interventions are mediated with this information it will be possible to tailor interventions according to the specific needs of diverse populations allowing the reshifting of available resources to the best of their use a mainstay of reshift is to activate ambitious implementation and dissemination measures to let a different range of stakeholders lay people organizations general public patient and family organization advocates to know about the project its aims deliverables and potential impact of its findings on the society training activities will last for the entire duration of the project and results will be presented in toptier international conferences and submitted to high impact factor international peerreviewed journals reshift is concrete and ambitious its findings will be globally applicable and serve as a blueprint and impetus for other projects aiming at promoting mental health equity
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recapitulating and preventing epileptogenesis in early human brain network development
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epilepsy is one of the most common neurological disorders yet current treatments fail to prevent seizures in more than a third of cases 37 most drug targets focus on seizure suppression however these are symptoms of abnormal developmental changes in the neural network the processes that give rise to epileptic brain regions are summarized by the concept of epileptogenesis therefore preventing epileptogenesis is critical for longlasting seizure freedom studying epileptogenesis is challenging as the developmental processes involved in it occur before birth during neurodevelopment itself recent progress in stem cell models however has the potential to change this the knoblich lab pioneered the use of human cerebral organoids to model disease invitro such as tuberous sclerosis tsc cortical tubers are the source of drugresistant epilepsy dre in tsc which our recent study eichmüller et al science 2022 uncovered to originate from a specific precursor cell type clip cells strong preliminary evidence shows that pathological processes are occurring in tsc organoids which recapitulate epileptogenic electrical biomarkers called high frequency oscillations hfosin this proposal i will utilise our brain organoid model to understand human circuitlevel dysfunction in epilepsy and identifyevidencebased causal treatment for epileptogenesis prevention therefore i plan to classify stages of epileptogenesis in human brain tsc organoids using largescale signal features and indepth molecular characterizations to identify biomarkers for abnormal circuit initiation and progression i will reveal stagespecific druggable targets for epileptogenesis and then test novel antiepileptogenic compounds on pathological network activity prevention together this project marks a change in the approach towards epileptic drug discovery to combat the significant socioeconomic burden of drugresistant epilepsy
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twoloop renormalization of the smeft and the wet
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the matching of the smeft onto the wet ie expressing the wet parameters in terms of the smeft wilson coefficients is known since recently up to the oneloop level these matching conditions depend however on unphysical entities and can therefore not be used in a consistent phenomenological analysis in order to remove this scheme dependence the twoloop renormalization of the wet parameters needs to be taken into account since it cancels this scheme dependence and therefore makes the results physical again one objective of the current research project is to compute the full twoloop renormalization of the wet wilson coefficients and implement the results in the public code wilson a second objective of the research project is to conduct the full twoloop renormalization for the smeft parameters performing the twoloop renormalization is motivated by the fact that at this order many more smeft wilson coefficients become phenomenologically accessible through running effects which therefore allows for a broader and more precise np search another goal of this computation is again to remove unphysical dependencies that are present in the matching conditions although the full oneloop matching from general bsm theories onto the smeft is currently unknown it is however expected to be available in the very near future together with the proposed calculation these matching conditions can then be used to perform a consistent and completely general nlo analysis of smeft parameters
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network synergies in tissue homeostasis and stromal prevention of inflammatory disease
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inflammation has evolved to protect us from the outside world however in doing so it consumes large amounts of energy and causes collateral damage thus requiring strict control on multiple levels while the mechanisms that govern inflammation once ongoing are well defined we lack basic knowledge of the processes that regulate its actual onset in vivo only by understanding the mechanisms that orchestrate tissue stress responses and defend against unwanted inflammation will we pave the way for new therapeutic approaches in future precision medicine not only treating inflammation once it is active but preventing inflammatory disease from developing in the first placei hypothesise that prevention of inflammation can be accomplished at the level of tissue homeostasis and cooperative stromal biology the stroma that underlies any given tissue is not a passive scaffold instead it comprises a functional network that regulates key aspects of tissue physiology as an adaptive and selforganising system homeostat resident tissue macrophages rtm the tissues very own regulators of inflammation are physically connected to this homeostat and thereby directly integrated into its cooperative signalling grid hardwired communication mechanisms and synergies allow rtmstroma networks to operate as a functional syncytium a hitherto unknown operating system that coordinates stress responses and actively prevents the onset of inflammation here i propose a pioneering tissue biology approach to decipher the stromal homeostat by combining unique bioimaging with computational 3d reconstruction and multidimensional profiling i will quantitatively unravel complex cell interactions to explain the mechanisms and implications of stromal network communication in a living tissue thereby i aim to elucidate homeostatoperating principles and establish topdown control of inflammatory tissue checkpoints in order to apply them to clinically relevant inflammatory diseases
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two isotopes for neutrinoless double beta decay search
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the tiny experiment will focus on the investigation of neutrinoless double beta decay 0n2b with 96zr and 150nd isotopes the search for 0n2b is a hot topic in particle physics as the discovery of this rare nuclear process would establish the majorana nature of neutrino fix the neutrino mass scale and prove lepton number nonconservation setting the grounds for new physics beyond the standard model the current and nearfuture largescale searches for 0n2b do not include the nuclei chosen for the tiny project due to the unavailability of an appropriate scalable detector technology for these candidates both 96zr and 150nd have the crucial advantage of very high transition energy for the 0n2b process which would allow obtaining a higher sensitivity to the effective majorana mass compared to other isotope candidates bolometric detectors with high energy resolution and active particle identification will be developed during the project execution 96zr will be embedded into zro2 crystals measured with thermal sensors and coupled to auxiliary light detectors for active alpha particles rejection 150nd will be studied with magnetic ndgao3 absorbers and athermal phonon sensors particle identification will be achieved via pulse shape discrimination the first ever efficient measurement of a magnetic compound as a bolometer will open the way to new opportunities in lowtemperature particle detection the tiny pilot experiment consisting of afewkg scale underground demonstrator will be able to set the best limits worldwide on the 0n2b halflives for both 96zr and 150nd isotopes very low background in the region of interest will be obtained thanks to high transition energy and alpha rejection not only will this project be competitive in the international context on a short time scale but also it will open up new perspectives for tonscale experiments that can surpass any existing technology in terms of sensitivity to the majorana neutrino mass
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translational research and innovation in ophthalmology vision centre of excellence
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eye diseases affect the daily lives of 22 billion people globally and have a significant socioeconomic impact however recent advances have rapidly progressed our understanding of the mechanisms of ophthalmic diseases opening unprecedented opportunities in the field of eye therapeutics the development of new technologies robotics ai and health services virtual clinics offers new solutions to improve the quality of life of ophthalmology patients and to reduce the costs and burdens for national healthcare systems in the triovi project we address these challenges focusing on translating the latest advances in science and technical research into practice in vision care together with strategic partners from ucl and sorbonne we create a centre of excellence the international center for eye research icter coe in warsaw a subunit of the institute of physical chemistry of the polish academy of sciences unlocking scientific and translational potential of icter coe guarantees tremendous impact on society science education and health by accelerating introduction of therapies and new solutions in vision care it will boost the rapidly growing biophotonics and biomedical engineering industry in poland by introducing new devices in ophthalmology as a result of triovi we anticipate a considerable improvement in rdi capabilities in ichf and icter through enhanced education training and integrated skill development for all employee groups with a focus on excellence gender equality and multidisciplinary collaboration thus we aim to strengthen the ri system in poland attract eu funding increase visibility of polish rd institutions in eu and beyond and substantially become a gamechanger for paradigm of ophthalmology in central europe by boosting the changes icter coe will become a lighthouse for the polish academy of sciences the largest research institute network in the country and the scientific landscape in poland and in the region
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robot manipulation of deformables through dynamic actions
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robot handling of deformable objects such as textiles is a research topic that has hit fertile ground with the advancement and accessibility of robot hardware a change in thinking of application of robotics also outside of factories and especially novel control and perception methodologies stemming from ai approaches the topic has sprouted different independent research efforts all over the world and in europe at jsi after some initial experiences we recognize the potential impact in academia and society of this new research area and believe we can become an important player we want to combine and bring forward separate efforts on this topic by making a network of academic and industrial stakeholders in combination with policy makers and regulators create a roadmap for the future and become a center of excellence coe in robot manipulation of deformables in the truest sense of the definition as a network of institutions collaborating with each other to pursue excellence in a particular area the proposed twinning project initiative romandic robot manipulation of deformables through dynamic actions will provide the means to promote this novel and exciting field of research at jsi and internationally but more importantly facilitate and consolidate the managing and leading capabilities of jsi through knowledge transfer and exchange of best practice so that it can indeed act as an informal coe the three participating institutions have the complementary expertise required to succeed in the research aspect of romandic and also the infrastructure and organisational experience required to create and promote best practices and lead initiatives at the national and international levels the three institutions collaborated already in the past in several eu projects
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dependable smart energy systems
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the dn dense is addressing individual research projects and training of doctoral candidates dcs in the innovative dependableengineering of smart energy systems sess with the main focus on robustness as well as preventive and corrective actions under uncertaintywithin this concept the term smart energy systems sess refers to a holistic crosssectoral approach eg electricity heating coolingindustry buildings and transportation aimed at excelling the transformation towards sustainable and achievable future energy systems hence it both covers but also extends beyond the smart grid approach which is mainly focused on the electricity sector consequently sess exhibit the following attributesi complex interactions on subsystem and crosssectoral systemsofsystems levelsii cyberphysical characteristics with digital and physical network connectionsiii ability to operate in nonstationary uncertain and severe environmentsdependability of complex networks such as sess characterizes their ability to deliver service that can justifiably be trusted thus dependability comprises system attributes such as availability reliability safety integrity and maintainability a key requirement of dependability is the desire for providing justifiable trust in the system performance hence rigorous systems engineering yielding provable performance guarantees throughout the systems life time is already required at the design stage this challenge is tackled in dense with a focus on operational robustness as well as preventive and corrective actions in sess as a consequence dense is wellaligned with the eu commissions headline ambitions on the european green deal as well as the strive for grasping the opportunities from the digital age while increasing social fairness and prosperity
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research facility 20 towards a more energyefficient and sustainable path
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research in many cases requires large infrastructures which often use significant amounts of energy in particular research at some of the largescale facilities such as particle accelerators which are either hosted or used at european level are very energy intensive power usage may reach 100 mw or more with energy consumptions comparable to small towns to make progress in science these largescale infrastructures are essential despite their energy consumption requirements at the same time our society is faced with the enormous challenge to transition into a carbonneutral economy and to minimize our footprint in terms of energy usage from nonrenewable sources and our output of substances which burden the environment for this reason research infrastructures need to develop and use energy efficient technologies the way we operate our infrastructures needs to be reevaluated intelligent solutions which reduce energy consumption need to be developed through intelligent algorithms the energy usage of our infrastructures needs to be adjusted to the available resources such as renewable energy and should help in providing an overall stable energy supply to societythe rf20 consortium vision is to design and operate accelerators in the way that they can run safe and stable anytime on 100 renewable energy supply ie almost independently from the public power gridto achieve this vision comprehthis projects originality lies in the comprehensive analysis of large research infrastructures energy management problem from component to system level both at experimental physics and energy engineering level and in developing and testing in realistic environments of possible corrective actionsthe rf20 project will involve 6 world renowned research infrastructures for the acceleration of particles of which 5 of european interest an energy technology lab and 4 smes focused on the codevelopment and technology transfer of new energy solutions
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neutrinai energyfrugal internet of things networking with generative ai modules
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this project aims to design energyefficient communication technology and protocol for the 6th generation 6g internet of things iot communication system in which energy efficiency is one of the essential key performance indicators kpis to realize sustainable iot networking the energyefficient protocol designs for iot devices serving 6g applications are more challenging than conventional wireless sensor networks as we need to consider the energy cost caused by the introduction of the artificial intelligence ai machine learning ml model as well as that of the primary radio circuit however most related works do not consider the energy cost of introducing the ml model which affects the overall energy efficiency of the communication protocols in order to realize the reduction of the overall energy consumption of aiempowered iot devices this project newly introduces generative ai modules and wakeup radio technology into iot devices operating with batteries by which iot devices can suppress unnecessary data transmission and communication is taken place in an energyefficient manner by cooperatively transmitting signaling informative data and ml model from devices to devices this project will design a new communication framework integrating generative ai modules investigate the systemlevel performance of gaibased communication systems and clarify the gain brought by the introduction of gai modules in terms of energy efficiency and accuracy
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engineering and delivering b cells using biomaterials against breast cancer
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breast cancer bc is the most diagnosed cancer worldwide and despite treatment availability the disease remains challenging to treat causing substantial adverse side effects and fatalities globally the lack of efficacy and inaccessibility of standard care supports this demand for better treatments this is demonstrated by resection surgery and current neoadjuvant therapies such as chemotherapy exhibiting inadequacies resulting in 30 of bc patients having metastases these percentages are even higher in low human index regions due to inaccessibility cost and growing populations adoptive cell therapy act such as cart is a category of emerging immunotherapies expected to impact oncology by transferring engineered immune cells into a patient to eliminate cancer cells however these treatments are currently ineffective in bc and costlyendbc will complement research into b cells to produce an act that improves treatment efficacy against breast cancer while reducing side effects and costs from effective therapy our research developed novel biomaterial to overcome significant obstacles to successfully enhance b cell functions against cancer using a lowcost method in endbc we will research the commercial and technical feasibility of tailoring the b cell act with biomaterials to determine its potential to treat bc
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taking action to prevent and mitigate pollution of groundwater bodies
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groundwater is a key resource for water supply which is currently jeopardised by i saline intrusion ii pollution with pesticides and nutrients agriculturefarming pharmaceuticals and antibiotic resistance genes from wwtp effluents hydrocarbons and heavy metals runoff and microplastics both iii global and climate change effects although several initiatives have developed actions and tools towards groundwater monitoring and protection additional knowledge is needed to understand the synergistic effects and risks of multiple stressors and pollutants and to develop costefficient groundwater monitoring strategies pollution preventionmitigation technologies and earlywarning dss ninfa will provide a novel strategy based on an earlywarning dss and knowledge database ninfa platform and innovadiffuse pollution affects 35 of the area of groundwater bodies with contaminants such as pesticides herbicides and nutrients leading to eutrophication and lack of oxygen other pollution sources including sewage from wastewater treatment plants wwtps and runoff infiltration in cities especially during storm events contaminate groundwater with contaminants of emerging concern cecs such as pharmaceuticals microplastics and antibiotic resistance genes and with hydrocarbons and heavy metals respectively moreover aquifer exploitation for water consumption leads to increased pressure on groundwater resources which may be aggravated by climate change lack of aquifers natural recharge in coastal aquifers this problem is worsened due to saline intrusion mainly caused by water extraction which affects the quality of the groundwaterthe innovative concept of ninfa is to facilitate the transition to a more effective decisionmaking system in groundwater management by widening the knowledge on water flows the insitu mobility and transformation of cec and establishing predictive models to promote the treatment and reuse of water and its quality
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advancing measures to reduce aviation impact on climate and enhance resilience to climatechange
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the interconnection between aviation and climate is very tight on the one hand air traffic contributes to greenhouse gas emissions that alter the composition of the atmosphere globally hence driving climate change on the other hand atmospheric processes significantly impact the whole chain of aviation changes in temperature affect infrastructure and aircraft performance variable wind and precipitation patterns increase delays and cancellations etc in recent years researchers put a strong effort in investigating the impact of aviation on climate and ways to mitigate it putting these knowledge advancements into practice requires further development of the climate impact assessment methodology towards the deployment and implementation phases in addition to these efforts new adaptation measures are necessary to make the aviation sector less vulnerable to the unavoidable changes in climate conditions which we are already experiencing such as heatwaves and other highlyimpactful weather phenomenaobjectives the project aims at developing a toolset for reducing the aviation impact on climate and to enhance the sectors resilience to climate change the idea is to advance the knowledge and operationalize the monitoring on the impact of aviation on climate and concurrently to assess the resilience of the aviation sector to the exacerbation of extreme events due to climate change
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control of host mechanics by a bacterial pathogen and functional impact
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mammalian cells sense and exert forces on their environment and their responses to mechanical signals regulate their growth motility and behavior within tissues however little is known about the forces at play during microbial infections and their impact on tissue homeostasis and disease progression i recently found that binding of the extracellular bacterium neisseria meningitidis nm on the endothelium leads to the generation of large traction forces on the extracellular matrix this is due to the formation of a new structure that i called ancreopodia linking the bacterial colony on the apical side of the host cell to the basal side and underlying substrate i hence hypothesize that nm induces longrange force transmission throughout the infected cells leading to alterations in tissue functionin this project i propose to dissect how host cell mechanics is affected by nm infection and how mechanical forces globally impact tissue barrier physiology in epithelia and endothelia by developing quantitative tools to directly measure forces while imaging host cells during infection both in vitro using 2d and 3d models of tissue barrier with increasing complexity and in vivo i will 1 identify the key molecular mechanisms involved in host cell structural remodeling and their regulation in space and time 2 characterize the mechanics of the infected host tissue using biophysical tools and theoretical approaches to link signaling to the forces involved and 3 study the functional consequences of infectioninduced mechanical imbalance on cell fate and host tissue integrity this study has a double interest to better understand the impact of mechanics in the process of infection for the development of new therapeutic strategies and to bring new fundamental knowledge on the mechanical homeostasis of tissue barriers by integrating extracellular pathogens as new tools to shed light on complex feedbacks between cell architecture mechanics and function
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plantpowered energy harvesting system for iot solutions
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plante is the worlds only company harvesting energy from living plants without harming them a womenled startup plante launched in 2009 as a spinoff of wageningen university based on the phd research of marjolein helder our ceo plantes team has 20 years of commercial experience multiple phds and 10 years of rd experience in this field pushing our growth to 2 granted patents and 3000 prototypes tested so far with a business model based on device sales and maintenance fees we entered the smart lighting and sensoring market with custom projects the park of tomorrow in rotterdam nl is an interactive lighting system in a park and together with esa data was collected and sent into space by pmfc power plante technology doesnt emit any greenhouse gases such as co2 or methane on the contrary it acts as a carbon sink capturing up to 2 kg of co2kwh produced as such plante contributes to the zero pollution and carbon neutrality ambitions set by the eu
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performance optimization of a hybrid offshore windwave energy platform
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floating offshore wind turbines fowts have become an emerging trend in wind energy development in the past few years they offer the possibility of a clean power supply for highly populated countries with access to a deeper offshore area the main hurdle with fowts is that they need to be stabilized since platform motion is undesirable it makes the rotor aerodynamics and control more complex and reduces aerodynamic efficiency additionally platform motion increases stress on the blades rotor shaft yaw bearing and tower base and it can reduce the component lifespans fowt platform motions in pitch roll and heave must be limited within an acceptable range some researchers hypothesized that the platform stabilization may decrease the need for the platform steel mass active ballast orand taut mooring linesperformance optimization of a hybrid offshore windwave energy platform pohowep is a project which aims to 1 combine a fowt with oscillating water columns owcs to harness both wave and wind energies and 2 improve the stabilization of the fowt using the owcs as an active structural control the owcs will be integrated into the floating barge platform which has not been investigated in previous research works a machine learningbased control strategy will be developed to control all the power takeoff systems of the owcs at once the control of multiple owcs on a single fowt requires an adequate strategy that takes into account not only the plants state variables but external environmental conditions as well wind speed wave speed wave heights etc the consideration of this external data motivates the use of a machine learning ml module for the estimation and prediction problems an ml module will help in the prediction of future wind and wave speeds and estimate the proper reference input value of the designed controllers many research works using ml for fowts have been published and proved that ml is a promising solution
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natural products research at latvian institute of organic synthesis as a driver for excellence in innovation
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the aim of natalion is to foster innovation excellence of lios by the establishment of the natural products research npr group and implementation of the lios innovation hub as a complementary structural change the introduction of new research strands and the structural changes will be achieved under the leadership of era chair holder dr stefano donadio an experienced research and innovation ri professional project objectiveso1 establishment of the npr group including its capacity buildupo2 setting up the research directions of the npr group with a focus on new technologies and productso3 integration of activities of the npr group into internal and external collaborative projects including 3i mobilityo4 increase competitiveness for attraction of external research fundingo5 establishment of the lios innovation hub and its integration into institutional national and eu ecosystemso6 development of a motivating and inclusive institutional environment which fosters innovations and entrepreneurial culture o7 enabling institutional compliance to era priorities and un sustainable development goals o8 dissemination and exploitation of the results of the npr group according to pedr and a communication planestablishing the npr group the international recruitment as well as the development of environment fostering innovations will nurture brain circulation for researchers and innovators the establishment of the lios innovation hub and its integration into institutional national and eu ecosystems will deliver institutional reforms with a focus on innovation setting up new research directions and integrating the npr group into internal and external collaboration networks under the competent guidance of the era chair will leverage excellence of ri and increase the competitiveness for attraction of external research funding better communication of ri results to society will be achieved by dissemination and exploitation of the project results
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new life for biowaste as a sustainable soil improver
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with a share of 34 biowaste is the largest single component of municipal waste in the eu recycling of biowaste is key for meeting the eu target to recycle 65 of municipal waste by 2035biowaste can significantly contribute to a more circular economy delivering valuable soilimproving material and fertiliser as well as biogas a source of renewable energy biochar is a pure high carbon form of charcoal obtained through the pyrolysis of biomass such as biowaste biochar helps regenerate soils by enhancing waterholding capacity nutrient uptake soil fertility stimulating microbial activity and diversity and acts as a carbon sinkhowever a lack of understanding and evidence of the agronomic benefits and economic returns mean that biochar faces barriers to become a widespread soil improver biogas from anaerobic digestion ad is a renewable energy source yet the cost of disposal of its effluents digestates reduces profitability and uptake of new ad projects even though the digestate is rich in nutrients and can be used as a biofertilizer research shows that the combination of digestate and biochar creates a biofertilizer with increased fertility improved stability and excellent soil regeneration properties furthermore biochar could be a powerful additive to enhance microbiological activity in ad plants the fenix project will optimise biochar for different soils using ad digestate fenix will demonstrate the agronomic and economic returns of its soil improver in field tests trl 8 in three countries in the west and south of europe fenix brings together partners that cover the full value chain and with entrepreneurs that will be ready to take up the project results successful completion of the project will contribute to the recovery of abandoned poor soils increase eus soil quality and water retention capacity climate change mitigation secure and independent energy supply and sustainable biowaste management
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the multiple layers of childhood adversity
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health inequality is a major societal challenge and evidence suggests that health inequality is established in childhood and may even transcend generations childhood is a sensitive period with rapid growth and development and adversity during this period may have longlasting health effects more importantly multiple forms of adversity intersect with each other and disadvantaged children are often exposed to adversity across multiple biological health social neighbourhood and environmental layers but the childhood adversity literature has almost exclusively focused on social adversity this is a major gap in our understanding and empirical data which transcends multitude layers of adversity and follows individuals over entire life courses or across generations is lacking with layers i am in a unique position to meet this challenge by creating a unified data infrastructure for life course analyses of multiple layers of childhood adversity in 2m people over three generations combined with an interdisciplinary fusion of methods from data science epidemiology econometrics and systems science within a newly developed complex systems framework this innovative combination of data and methods will allow for a systematic generation of knowledge on the patterns of health inequality that emerge in early life and transcend generations the mechanisms which generate these patterns and the dynamics that make them change over time to translate these insights into actionable public health layers will establish a realworld policy data lab which integrates evidence from nationwide policies and simulations combined these interconnected elements will redirect the next frontier in health inequality research towards the multiple layers of adversity which generate inequality over the life course and across generations ultimately this will help us break vicious circles of adversity by identifying children and families who would benefit from targeted support
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the causes and consequences of firms focus on artificial intelligence
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the european union eu attaches critical importance to ai with its new strategy called the european approach to ai the eu aims to boost investment to foster the uptake of ai by eu firms while the potential of ai is widely acknowledged it is not evident that the focus on ai will translate into the targeted economic benefits to date we lack empirical evidence about the firmlevel consequences of firms increasing focus on ai the reason for this lack of knowledge is a paucity of firmlevel datain this project i contribute to our understanding of the causes and consequences of firms increasing focus on ai by using a large firmlevel dataset first i use automated textual analysis to create a unique measure that captures firms focus on ai the measure is based on publicly available documents and allows separating between different ai capabilities second i investigate what causes firms to focus on ai the answer to this question will be of critical importance to policymakers it helps them to use the most effective mechanisms to increase ai uptake third i investigate the effect of firms ai focus on a efficiency b innovation and c employment understanding the consequences of firms increasing focus on ai is crucial for policymakers the findings of this project guide them in making efficient investments and designing policies that benefit the workforce
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towards a gene therapy for agerelated macular degeneration amd
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while the blood neural barriers represent significant hurdles for the development of gene therapies for neurological and ophthalmological conditions it is now becoming clear that many of these conditions actually present with disrupted barrier integrity as the driving force of the pathology included in these diseases is age related macular degeneration amd in which we have shown that the blood retina barrier brb is subclinically disrupted and is a key driving force for disease progression erc funded retina rhythm project specifically related to this proof of concept grant a novel form of therapy for the end stage of amd namely geographic atrophy ga is now desperately needed a targeted approach to locally delivering adeno associated virus aav to endothelial cells of the brb would offer the opportunity to restore barrier function and prevent disease however the current tools available to achieve this localized approach to gene therapy are not optimum here we will use an exosome encapsulated and endothelial cell specific aav to achieve robust transduction of retinal endothelial cells this modified and optimized aav optiaav will represent a novel tool in translating recently identified biological mechanisms into real and meaningful therapies for patients
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geodesics and geometricarithmetic intersections
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this project will develop several aspects of a theory of real multiplication rm seeking to be a counterpart of the theory of complex multiplication cm discovered in the 19th century classical cm theory is famed for its beauty and elegance and is important in a variety of contexts for instance 1 in the classical era it arose in the context of explicit class field theory this feature is the subject of kroneckers jugendtraum and hilberts 12th problem2 in the modern era it has been instrumental in proving known cases of the birchswinnertondyer conjecture notably the results of grosszagier which are a main theme of this proposal 3 it has been used in elliptic and hyperelliptic curve cryptography in cryptosystems based on supersingular isogeny graphs one of the front runners for a secure postquantum international standard the objectives are to develop analytic computational and geometric aspects of such an rm theory and address the full scope of these features the theory is based on the notion of arithmetic intersections of geodesics and this project gives a new approach towards rm theory based on a notion of padic weak harmonic maass forms and padic height pairings of geodesics attached to real quadratic fields emphasis will lie on analytic aspects padic borcherds lifts and padic mock modular forms computational aspects development of userfriendly software for computations in rm theory and geometric aspects rm cycles on shimura curves and applications to the birchswinnertondyer conjecture
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alternative proteins from microbial fermentation of nonconventional sea sources for nextgeneration food feed and nonfood biobased applications
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promiseang is a 48month project that aims to develop novel alternative proteins from marine underexploited sources marine invertebrate and macroalgae discards and industrial biowastes through biomass fermentation solidstate and submerge processes generating new microbial protein biomass meeting market requirements for food feed and nonfood biomedicine pharma and cosmetic biobased applications a technically and economically viable biorefinery for microbialbased protein production will be demonstrated during the project enabling higher production yields reduced production periods minimized environmental impacts diminish the imports and reduced production costs for proteins promiseang contributes to cbe ju with a translational multidisciplinary and multiactor approach including cooperation between industries and academia across eu to achieve a greener biobased europe following a zerowaste approach promiseang will also recover and biosynthesize interesting nonprotein bio compounds and molecules ie polysaccharides lipids polyphenols pha etc for further use in food feed and nonfood applications research on novel protein streams from sustainable alternative sources will contribute to increase the protein availability in the eu and reduce the actual dependency on imports in short promiseang will upcycle of marine food wastes wp2 apply innovative and sustainable technologies incl biotechnology biochemistry microbial fermentations digital tools and machine learning wp3 validate the nutritious safety and bioactivities of protein products wp4 valorise fermentation side streams through nanotechnology wp5 and design development and validation of food feed and nonfood products in relevant environments wp6 including improvement of environmental economic and social aspects and productionefficiency performances wp7 and strong communication dissemination and exploitation plans wp8
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cooption of host circadian rhythms in cancer
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circadian rhythms crs are the biological response to the periodic rotations of the earth and allowfundamental adaptations of organisms to a changing environment crs are molecularly controlled in every cellby a set of transcriptional factors that control and are influenced by core biological processes includingmetabolic immune and proliferativemy previous studies established for the first time that innate immune cells regulate the circadian physiologyof tissues including the susceptibility of the lung to be metastasized in inntime i ask the reciprocalquestion to reveal if tumors take advantage of and subvert crs of the innate immune and stromacompartments to escape antitumoral defense inntime aims to understand how oncogenic processesrewire crs of the host and to elucidate strategies that halt this subversion as a new approach to fightcancer using lung cancer as proofofprinciple i will first investigate cellintrinsic circadian programs intumors aim1 next i will define how tumors coopt circadian clocks of the host and explore how themolecular clock of innate immune aim2 and supporting stromal cells aim3 impacts tumor growth bothmolecularly and functionally by integrating multiple transcriptomics and functional approaches inntimewill discover novel regulatory programs in tumors using a circadian approach and pave the way to designstrategies to prevent cancer by interfering with tumorsupportive circadian programsinntime will revolutionize the way we understand cancer as it will identify the malignant roots ofcircadian rhythms and their impact on host defense this research will establish a new paradigm by revealingthe mechanisms underlying protumorigenic clocks and will provide robust foundations for new therapiesin a set of disorders in which circadian clock dysfunctions are implicated
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peptidedrug conjugates for weight loss maintenance
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the worldwide rise in obesity rates is causing significant harm to human health while effective weight loss therapies are emerging the challenge of maintaining weight loss remains unresolved with this project we will leverage expertise in drug development to engineer novel peptidedrug conjugates designed to obstruct homeostatic weight regain in a cell specific fashion in the food deprived state a subset of hunger promoting neurons undergo structural changes that increases excitability and thus drives homeostatic weight regain capitalizing on our knowledge of g proteincoupled receptors gpcrs expressed in hypothalamic cell populations we will develop gpcrtargeting peptidedrug conjugates specifically designed to obstruct weight recidivism to evaluate this drugtargeting approach neurobiological methods including fiber photometry will be employed to confirm target engagement preclinical models are used to investigate the translational potential for treatment of weight loss maintenance following dietary and pharmacological weight loss interventions the molecular mechanisms of action and receptortarget selectivity of the conjugates will be determined using lossoffunction mouse models pharmacokinetic properties of lead candidates will be optimized by incorporating chemical halflife extenders this bridging between medicinal chemistry neuroscience and pharmacology will give rise to new multimodal molecules targeting homeostatic weight regain mechanisms to address a vastly growing unmet medical need for weight loss maintenance pharmacotherapies
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a programme to open the access to womenled digital deep tech startups to new opportunities under the umbrella of corporations in europe
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a recent study indicates that women raise funding receive significantly lessa disparity that averages more than 1 millionthan men corporates are different players compared to venture capital firms even their investment arms cvcs do have a different approach to the investment policiesspecifically targeting womenled companies to collaborate with corporates under a paidpilot scheme that can really take womenled startups and corporate collaboration to the next level open horizons proposes a novel approach towards covering the womenled companies funding and corporate network gap by creating a full programme from scratch that relies in the work done by other initiatives women techeu or empowomenthe consortium aims to invest 12m in startups and is comprised by an experienced consortium of partners as pedal reputed consultancy in eu projects also specialised in public procurement sploro experts on cascade funding and innovx eic partner and leading acceleratorcorporates are also linked to the proposal as partners like migros retail or associated partners like siemens industry software repsol energy and stahl manufacturing and planning to expand up to 10the projects structured approach includes identifying and formulating corporate challenges inclusive talent scouting across europe and facilitating the funding and implementation of pilot projects within realworld corporate settings postpilot the programme focuses on expanding growth opportunities for startups by connecting them with investment channels and helping negotiate commercial agreements for longterm collaborationsthis comprehensive strategy not only provides a platform for womenled startups to showcase their innovations within major corporations but also integrates them into a broader corporate and innovation ecosystem ensuring sustained growth and significant market presence
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performance optimisation and productivity 3
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the key element to ensure efficient use of hpc infrastructures is to optimize the performance and efficiency of the applicationsthe centre of excellence on performance optimization and productivity pop coe wwwpopcoeeu was initiated in october 2015 with the fundamental purpose of assisting a broad community of hpc application developers and users in both science and industry domains helping them to understand the performancerelated issues of their applications and thus improve their efficiency and productivity this fundamental purpose is reached by externally and objectively auditing the performance of the codes to all interested users by providing not only qualitative but also quantitative analysis through the use of pop tools and methodologythe current proposal performance optimization and productivity 3 pop3 is articulated in 3 main pillars services users and codesignpop services mainly focus on performance assessments with the goal to evaluate code performance and scaling identifying the main sources of inefficiency and providing some insight and recommendation about how to improve it pop3 also provides second level services that have been extended and include proof of concepts energy efficiency and advisory studies although pop3 will continue targeting all scales and types of users with this proposal we will focus our efforts on larger scales assessing the execution on the eurohpc sites of some of the european flagship hpc applications for other coes however pop3 will still provide services to prescribers and smes to promote an efficient usage of the computing resourcesthe codesign will be covered in two dimensions internally in pop3 we will codesign the tools and methodology to be able to analyse the applications on the selected platform at the selected scale externally pop3 will identify best practices and kernels that will be offered to other european projects as well as the wide audience of parallel applications
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dynamic management of aircraft configuration and route structures
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the dynmars project aims to minimise the environmental footprint of flights during climb descent and approach through novel avionic functions and improved arrival routes and procedures it enables for the first time a complete holistic solution that combines airborne with air traffic management atm improvements connected by enhanced communication capabilitiesdynmars builds on previous sesar work through the development of the permanent resume trajectory function the concept of dynamic deployment of arrival route structures the dyncat projects flight management system fms energy management function and new airground data exchanges in order to enable the visibility of the flight plan at both endsthe dynmars solution will consist of both an enhanced fms for aircraft and new airspace management techniques for air traffic control atc this solution opens the path for more environmentally friendly routing of aircraft in the terminal manoeuvring area whilst maintaining todays safety levelbased on the uplink of dynamically assigned routes and other information dynmars aims to allow pilots to better plan their optimum vertical and speed profile in descent and approach while maintaining the required runway throughput downlink of the fms computed trajectory allows for further improvement in the trajectory optimisation process between the aircraft and atc increased flexibility in atm will make it possible accommodate these optimised flight profiles dynmars will conduct 5 different exercises to validate its solution from both avionics and atm points of view with related human performance aspectsdynmars includes relevant aspects of air traffic management with new aircraft flight procedures to sustainably reduce the environmental impact of aviation co2 fuel burn and the noise exposure of communities whilst supporting the demand for high airport capacity and without compromising safety standards
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enable everyones engagemet in the energy transition
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the every1 consortium brings together leading experts in energy and education and experts in ecosystems combined with social sciences to deliver an impactful concept that includes all elements needed to enable an effective participation of all european stakeholders in the digital energy market every1 starts from a deep datainformed understanding of stakeholders and ecosystems citizen cities energy communities companies regulators and distribution grid operators to map who they are what they know how they use information and where they look for itsimilarly are existing and emerging solutions products and services assessed and validated and use cases will serve to understand what stakeholders need to know in order to take up a role that matches their potential this gap is used to develop learning pathways that lead to the identification of the needed capacity building materialparallel every1 works on making a market by exchanging best practices with policy makers and energy regulators enabling discussions on barriers and developing joint communication material for their peersa strong outreach campaign is launched which focusses on the local level with impactful social media campaigns material in various languages and spread through the media the local stakeholders use the operation of the ecosystems is based on the proven explore shape unite approach and includes guided oneonone support joint activities webinars matchmaking and more future ecosystems are actively engaged and trained while cooperation with diverse activities and networks will lead to a wider uptake of the capacity building material
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generation and verification of masking countermeasures against sidechannel attacks
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cryptography is everywhere in our daily life to ensure the confidentiality and authentication of our communications and the integrity of our records although there are strong expectations regarding the security of cryptographic schemes against blackbox attackers whose knowledge is restricted to a few inputs or outputs the security of their implementations is less challenged however once implemented on embedded devices cryptographic schemes become vulnerable to powerful sidechannel attacks the latter additionally exploit the physical leakage eg power consumption released by the device to recover the manipulated secrets with cheap equipment sidechannel attacks may yield tremendous damage eg full key recovery within seconds nevertheless the current security level of countermeasures is not yet close to that achieved in the blackbox modelthe community is divided on how to assess the security of cryptographic implementations from practitioners perspective they need to be confronted with concrete sidechannel attacks directly on embedded devices conversely theorists consider that such an empirical approach is not portable and does not yield concrete security levels eg not all attacks can be tested therefore they instead investigate security proofs based on abstract leakage models although the latter are often too far removed from reality to yield practical securityin this project i plan to combine the advantages of both worlds with a toolbox to generate and verify cryptographic implementations with practical security namely i aim toi design new compilers to turn any highlevel algorithm into an efficient implementation proven secure for identified concrete devicesii push the limits of formal verification with device characterization and polynomial complexity for industrial usethe main challenge of amaskzone is to design and verify cryptographic implementations so that they achieve measurable practical security
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humancentric ai platform for health and life sciences
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abzu aps an eubased deeptech startup is redefining the ai landscape with an explainable accurate and scalable solution the qlattice poised to disrupt the global ai race as the first truly responsible trustworthy and transparent ai with eic support and based on 15 pharma pilots with second to none explainable and accurate insights abzu will develop reason a tailormade platform for pharma readily utilized by noncode savvy rd scientists current black box solutions lack userfriendliness and have failed to restrain steady rd costs increases in the last 15 years 25b per drug today reason will reverse this trend with added value in key metrics of increased roi productivity and treatment availability abzus business technology and the eus strategic goals are at a unique crossroads of technological societal and economic disruption eic funds will make abzu the next eu unicorn and result in the eu disrupting and gaining a foothold in the global ai market
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novel soe architectures for hydrogen production
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hydrogen is a key energy vector in a future decarbonised economy largescale application in numerous sectors such as transport iron steel plants and the chemical industry requires efficient and sustainable production routes of green hydrogen electrolysis of watersteam using electricity from renewable sources like wind and solar is the solution high temperature or solid oxide electrolysis soel has significantly attractive features which allow for lower capex and opex thus facilitating commercial breakthrough high electrical efficiencies approaching 100 cost competitive nonnoble materials and operational flexibility soel challenges that need to be solved are increase of lifetime and reduction of degradation for realistic applications the ceramic brittleness of most mature soel configurations which challenge rapid operational strategies when integrated with renewable energy sources and scaling costs for the required mega to gigawatt volumesnoah2 aims at overcoming these challenges the overall goal of the noah2 project is to provide a robust costcompetitive flexible and durable stack concept for hydrogen production at intermediate temperatures through innovative electrode cell and stack designs noah2 will boost the electrolysis performance of solid oxide cells stacks significantly beyond stateoftheart soa through a combination of optimised structures and highly active materials with a focus on reducing critical raw materials crm and manufacturability using wellestablished large scale routes for solid oxide technology the noah2 stack architecture relies on a metal based monolithic concept with infiltrated electrodesnoah2 will outline a path towards commercialisation provide a sustainability classification with emphasis on substituting crm provide an assessment of commercialization potential compared to soa soel pem and alkaline electrolysers and identify potential industrial players for highvolume manufacture
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holistic rigorous numerical verification
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my goal is to make rigorous numerical verification widely applicable and practically usable rigorous verification proves at compiletime that a program computes for all valid inputs what it is expected to it is especially important for numerical programs which are widely used across application domains and are often safetycritical however automated verification of numerical programs over finiteprecision eg floatingpoint numbers is currently limited finite precision introduces rounding errors wrt an ideal realvalued specification and poses unique challenges for verification of program accuracy and other kinds of desirable properties as a result verification of nontrivial numerical programs today requires extensive expert knowledge and mostly manual proofs additionally when verification fails eg because a program is buggy developers have little debugging help availablei will rethink automated verification and debugging techniques for numerical programs from the ground up with accuracy as a core property i propose a novel approach for accuracy verification based on deductive relational reasoning that will be able to effectively bound the difference between the specified realvalued and actually computed finiteprecision program results my verification approach will be modular automated integrate with verification of nonaccuracy properties and allow safe program optimizations for realworld programs to further ensure the practical usability of the verifier i will develop complementary techniques that will help developers to debug unsuccessful verification attempts by helping to fix specifications localize faults in the program and communicate effectively with the verifieri will build on my comprehensive expertise with automated rigorous accuracy analysis and optimization of finiteprecision arithmetic and my recent efforts in deductive verification of floatingpoint runtime errors and numerical specification inference
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life is science in a world turned upsidedown
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our public events held in conjunction with the european researchers night ern in graz austria will be titled life is science in a world turned upsidedown lisworld the title signifies our central objective to showcase the vital role of science in navigating the complexities of todays world in the face of emerging global challenges public engagement for a more informed sustainable and scientificallyliterate society is paramount attendees will gain firsthand insights into the daily work of researchers and science communicators across various science disciplines highlighting the profound impact of science on our daily lives the events framework centers around four distinctive storylines earth explorers health investigators tech pioneers and science reporters these designations are chosen not only to pique the attendees individual interests but also to directly engage them in specific roles and give them the opportunity to earn a badge for example as a science reporter this immersive approach encourages active participation ensuring that each visitor can directly experience the heart of these scientific domains
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circular economy applied to electronic printed circuit boards based on paper
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the amount of ewaste correctly recycled does not meet the targets set by the ec the objective of circelpaper is to increase the amount of ewaste recycling by feeding it in the paper recycling process that is much more accepted by the consumer therefore circelpaper focusses on the widely used board technology printed circuit board pcb and aims for replacing the fibercomposite core material fr4 by paper technology based on positive experiences in manufacturing of circuitry on paper integration density has to be increased and sound evaluation of separation of used electronic materials in the recycling process has to be carried out in order to transfer the pcb technology to circular economy each process step lamination gluingsoldering manufacturing of vertical interconnects encapsulation etc is scrutinized and alternative approaches are developed in order to increase the part of the materials that are recyclable are biobased come from secondary raw materials or are at least harmless for the environment three different use cases in the field of medical application logistics and consumer electronics are realized demonstrating the performance of the paperbased pcb the circelpaper project is carried out by 3 rto fraunhofer project coordinator joanneum rise that care about novel material approaches and adaptation of process techniques three industries arjowiggins electronic paper replaced by f1 paper on january 1st 2023 vfp conductive inks and malmö mönsterkort printed circuit board as well as academic partners ginp investigating modification of recycling processes
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optimal high resolution earth system models for exploring future climate changes
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optimesm will develop a novel generation of earth system models esms combining highresolution with an unprecedented representation of key physical and biogeochemical processes these models will be used to deliver cuttingedge and policyrelevant knowledge around the consequences of reaching or exceeding different levels of global warming including the risk of rapid change in key earth system phenomena and the regional impacts arising both from the level of global warming and the occurrence of abrupt changes optimesm will realise these goals by bringing together four esm groups with integrated assessment modelling teams as well as experts in model evaluation earth system processes machine learning climate impacts and science communication optimesm will further develop new policyrelevant emission and land use scenarios including ones that realise the paris agreement and others that temporarily or permanently overshoot the paris agreement targets using these scenarios optimesm will deliver longterm projections that will increase our understanding of the risk for triggering potential tipping points in phenomena such as ice sheets sea ice ocean circulation marine ecosystems permafrost and terrestrial ecosystems optimesm will further our understanding of the processes controlling such tipping points attribute the risk of exceeding various tipping points to the level of global warming and develop a range of techniques to forewarn the occurrence of tipping points in the real worldartificial intelligence ai methods for statistical downscaling will be developed and applied to improve our understanding of the effect of longterm global change and tipping points on regional climate particularly extreme events new knowledge and data from optimesm will be actively communicated to other disciplines such as the impacts and policy research communities as well as the general public this knowledge will provide a solid foundation for actionable sciencebased policies
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parents and technology in cyberbullying intervention and prevention for future experts
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cyberbullying is a significant social health and behavioural concern throughout the eu and worldwide yet crucial areas in its prevention and intervention have largely been sidelined namely the key role of parents as well as the role of gender disability ethnicity and sexuality participate will address this research and action gap by delivering a worldclass multisectoral multidisciplinary doctoral training program incorporating plans for substantial networking and exchange of information expertise and action potential regarding the nature and extent of cyberbullying across europe by focusing on parents as well as on gender disability ethnicity and sexuality the project aims to empower both parents and young people creating a safer space online for our youth while placing europe firmly at the forefront of cyberbullying research and practice this dn brings together many of the foremost world leaders and cuttingedge researchers in the areas of cyberbullying prevention and is grounded in scientific excellence provided by academic partners across europe n6 with extensive previous experience of collaborating together this partnership in conjunction with a strong and diverse range of nonacademic partners including ngos youth foundations and internet safety organisations n8 will provide a robust multidisciplinary and intersectoral approach to finding solutions to cyberbullying the objectives will be achieved through a unique combination of individual and collaborative research work nonacademic secondments and workshops on scientific and applied skills facilitated by the academicnonacademic composition of the consortium the findings generated will produce both practical researchbased programs and european guidelines on cyberbullying in relation to gender disability ethnicity and sexuality we will generate approximately 40 scientific publications and engage the public with our findings through a marie curie ambassador program
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high mobility printed networks of 2d semiconductors for advanced electronics
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future technological innovations in areas such as the internet of things and wearable electronics require cheap easily deformable and reasonably performing printed electronic circuitries however current stateoftheart soa printed electronic devices show mobilities of 10 cm2vs about 100 lower than traditional sielectronics a promising solution to print devices from 2d semiconducting nanosheets gives relatively low mobilities 01 cm2vs due to the ratelimiting nature of charge transfer ct across internanosheet junctions by minimising the junction resistance rj the mobility of printed devices could match that of individual nanosheets ie up to 1000 cm2vs for phosphorene competing with si hypersonic is a highrisk highgain interdisciplinary project exploiting new chemical and physical approaches to minimise rj in printed nanosheet networks leading to ultracheap printed devices with a performance 10100 beyond the soa the chemical approach relies on chemical crosslinking of nanosheets with semiconducting molecules to boost internanosheet ct the physical approach involves synthesising highaspectratio nanosheets leading to low bending rigidity and increased internanosheet interactions yielding conformal largearea junctions of 10e4 nm2 to dramatically reduce rj our radical new technology will use a range of n or ptype nanosheets to achieve printed networks with mobilities of up to 1000 cm2vs a comprehensive electrical characterisation of all nanosheet networks will allow us to not only identify those with ultrahigh mobility but also to fully control the relation between basic physicschemistry and network mobility we will demonstrate the utility of our technology by using our bestperforming networks as complementary fieldeffect devices in next generation integrated wearable sensor arrays printed digital and analog circuits will read and amplify sensor signals demonstrating a potential commercialisable application
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improved coordination of national and european bioeconomy research and innovation programmes in the era through strengthened scar working groups
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the standing committee on agricultural research scar is a longstanding committee of eu member states and associated countries presided over by the european commission it has become a respected source of advice on european agricultural and wider bioeconomy research and has been a catalyst for the coordination of national research and innovation ri programmes it is supported in these strategic functions by scar working groups wgs including a foresight group which provide domainspecific expert advice and input refrescar will strengthen the strategic functioning and capacities of scar wgs in order to facilitate the improved coordination of national and european bioeconomy ri programmes through a toolkit of measures refrescar will provide robust scientific support to scar wgs through regular portfolio analysis of projects expert studies and support for the scar foresight process combined with practical administrative support this will enable a better structured organisation facilitation and reporting of scar wg activities in themes of relevance for horizon europe the common agricultural policy european green deal digital europe and the farm to fork and biodiversity strategies in order to boost the participation of underrepresented countries in scar wgs a scarengage programme will be developed involving tailored action plans financial and peertopeer support networking and knowledge exchange targeted support for communication and dissemination will immerse a broad audience of stakeholders in the activities of the wgs furthermore refrescar will cultivate connections between scar wgs key actors in eu policy practitioners and relevant eu and international initiatives through dedicated fora helping to build a bridge between ri policy and practice the outcome will be more impactful scar wgs that are better resourced and empowered to deliver strategic advice contributing to a strengthened scar within the european research area
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the geometrical and physical basis of celllike functionality
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can systems with lifelike properties be built from scratch with only a minimal set of components while progress has been made experimentally in the development of such minimal systems there is a lack of theoretical underpinnings that could provide mechanistic principles my goal is to discover such principles by combining theoretical modeling and insilico evolution to explore the potential for lifelike functions of minimal systems consisting of only two core elements of cells reaction compartments enclosed by lipid membranes liposomes and equipped with a protein reaction network towards this goal we will develop new multiscale approaches to investigate the mechanistic interplay between the ability of protein networks to form spatiotemporal patterns by decoding information about the membrane geometry and to reshape the membrane through mechanochemical feedback using methods from differential geometry we will develop projection techniques that reduce the model to the twodimensional manifold of the membrane building on my expertise with protein pattern formation i will design coarsegraining methods using machine learning concepts to link scales these theories will give unprecedented insights into the relative role of reaction networks membrane elasticity and mechanochemical feedback in forming different types of protein patterns and membrane morphologies moreover they will provide an efficient computational platform which i will use to insilico explore the potential of supported lipid bilayers with adhering liposomes as a platform to generate functions such as cell migration cell division and collective cellcell communication this will lead to theoretical insights into the mechanistic principles of the emergent behavior of these systems make specific predictions for established bottomup experimental model systems and provide innovative suggestions for the rational design of systems with targeted functionalities
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inspired to integrate filtering natures diversity for naturefriendly implementations
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nature provides an almost inexhaustible source of inspiration for innovative designs that may help to tackle many of the worlds current social economic and environmental challenges in accordance the potential of bioinspiration including biomimetics and biomimicry has become widely recognized in academia and industry the main hurdle preventing the field of bioinspiration from delivering its promises however stems from differences in tools practices and viewpoints of its practitioners often obstructing further development towards successful products nature4nature a unique joint effort of biologists engineers designers and manufacturers will immerse early stage researchers esrs in a learning environment that fully spans the inspiration integration and implementation aspects of bioinspired design to tackle the conceptual methodological and practical challenges it will provide esrs a with a mindset and knowhow to harness biodiversity into design b with the theoretical background and practical skills for transferring biological model systems into engineering designs and applications and c with an attitude and competence to implement bioinspired ideas in an explicit sustainable way nature4nature will focus its research activities onto one model system how to efficiently separate solid particles from liquids biological filtration systems have evolved repeatedly over the earths living history nature4nature will teach esrs to make the most of this rich heritage using it as an inspiratory source for designing and manufacturing highthroughput clogresisting filtering systems that can help conserving and restoring the worlds aquatic habitats by fostering a new generation of researchers operating at the interface between scientific disciplines sectors and societal actors nature4nature sets out to spur innovative practices and will aid in overcoming the barriers to implementation of bioinspiration in the design process
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advanced epigenetics studies to increase the research and innovations capacity of the roumen tsanev institute of molecular biology of the bulgarian academy of sciences
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the global objective of the roumen tsanev institute of molecular biology is to develop its traditionally strong focus on epigenetics and chromatin biology towards a worldclass level of research excellence our institute has identified prof stefan dimitrov a top level scientist and an internationally recognised expert in the field of epigenetics as a prospective era chair holder we intend to achieve significant improvements in research and innovations capabilities of the imbbas in the area of the institutes long term specialisation producing a clear impact on publication quality and newly acquired knowledge with translational potential this should be achieved by transfer of knowledge with a major focus on phd students and young postdocs to provide for sustainable growth of imbbas and reduce the brain drain
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nurturing heritage science with novel bioarchaeological methods in the eastern baltics
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paleomix proposes an interdisciplinary research programme to better understand cultural heritage as one of the main definers of european identity and grant its maximum informative value and longterm preservation paleomix bridges humanities and natural sciences by bringing together experts from the eastern baltic and western europe to implement topnotch bioarchaeological and computational research methodologies for conducting a more sustainable study of tangible heritage the twinning exercise consolidates the research and innovation capabilities of the internationally acknowledged research centres bioarch university of york uk and globe institute evo and eco genomics sections university of copenhagen dk and laboratory of human evolution isotopik lab university of burgos es to the coordinator university of tartu ee allowing the establishment of a dedicated researchinnovation ri hub on tangible heritage studies the transdisciplinary research excellence that becomes available through tight cooperation mobilities and creation of digital infrastructure paleomix oad in the e baltics is first demonstrated in the research pilot about the most important cultural change in human history neolithization with the push from the twinning partners the ri hub will become a selfsustainable naval point and a pool of knowledge to disseminate the best practices in heritage studies to regional researchers and other stakeholderson a wider scale paleomix promotes the integration of humanities and natural sciences to tackle prominent questions about european common heritage paleomix further i contributes to the sustainability of the knowledgebased society with its extensive knowledge production and dissemination among the general public ii strengthens the links between academia business and other governmental organisations through novel services offered by the ri hub and iii acts as a springboard for the next generation researchers in heritage studies
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nano and colloidal plastics in soil input plant uptake and risk assessment
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plastic pollution has been identified as a key to soil health yet information on inputs and concentrations in agricultural soil is limited to microplastics 1 m5 mm or larger particles but nothing is known about submicron plastics including colloidal plastics cps 11000 nm and nanoplastics nps 1100 nm due to a lack of analytical methods this is critical because mainly submicron plastics harm soil biota are taken up by plants and thus pose a risk to human health via the food chain as plastic pollution is rising we urgently need to quantify submicron plastics in agricultural soils and the resulting plant uptake and contamination of our food to safeguard our food production hence the nanosoil project is designed to test the following hypotheses i submicron plastics can be routinely detected using field flow fractionation fff with adaptions from environmental colloid tracing ii agricultural practices compost and sludge application wastewater irrigation plastic mulching are main pathways for submicron plastics into soil as well as iii the use of socalled biodegradable foils in agriculture i further hypothesize that iv uptake and accumulation of cps and nps in crops are polymer and plantspecific temperature and humiditydependent with mainly nps reaching edible parts to quantify submicron plastics i will i optimize a recently developed method using fff and pyrolysis gas chromatography this method will then iiiii be used on soil samples from agricultural fields with known plastic input pathways for conventional and biodegradable plastics including an europewide survey and existing controlled field trials finally iv plant uptake will be assessed for representative crops with my combined expertise in nanoparticle and plastic analysis in soil nanosoil will for the first time generate data that will form the basis for all future environmental fate and ecotoxicology studies of plastics and a robust risk assessment
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the early metabolic stages in the evolution of antimicrobial resistance
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antimicrobial resistance amr is a rising global health threat and rapid evolution of resistance against existing or newly developed antibacterial compounds is predicted to lead to 10 million deaths and 60 trillion of lost economic output by 2050 while resistanceconferring mutations their inheritance and spread by horizontal gene transfer are increasingly wellstudied our understanding of preresistant cells survival and resilience in the presence of lethal antibacterial doses remains unclear this proposal is stimulated by recent findings suggesting that the extracellular metabolic environment and metabolic adaptations play an overlooked role in transiently buffering antibiotic lethality and therefore increase the emergence of subpopulations of cells and their effective size that supports the evolution of antimicrobial resistance in this proposal i will systematically dissect mechanisms at work in subpopulations of preresistant cells of priority pathogens pseudomonas aeruginosa and acinetobacter baumannii that can transiently cope with antimicrobial treatment i propose to combine my expertise in bacterial physiology with the ralser labs ultrafast massivescale proteomics and phenomics technologies i will systematically investigate the metabolic stress response in clinically relevant conditions and identify the key metabolic and signalling processes that support the survival of subsets of challenged cells upon exposure to major classes of clinically applied antimicrobials finally adaptive evolution experiments combined with crisprcas9 gene editing will validate causal effectors of identified tolerance mechanisms that precede the appearance of resistanceconveying adaptations here i will acquire technical skills in innovative technologies and the host lab will benefit from my experience in working with pathogenic bacteria i will lead public engagement efforts and disseminate scientific research outputs on an important global health issue
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validation of magnetfree wireless charging and communication for intrabody devices
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cochlear implants cis which electrically stimulate the auditory nerve to repair hearing in people with severetoprofound hearing loss are used for more than 40 years however conventional cis have major drawbacks one of which is the use of magnet in the implanted unit of the ci to help perfect alignment of the coils that are used for rf link between external and implanted units however using magnets prevents the ci users from accessing some of the medical treatment and examination methods like mri and may lead to damage on the skin to eliminate the drawbacks of conventional cis including the magnet utilization we introduced flamenco concept which has demonstrated that a fully implantable cochlear implant fici mimicking the natural hearing mechanism of the ear is feasible in the erc flamenco project we developed the fici as a magnetfree device which necessitated development of a novel wireless power and data transfer wpdt application to minimize transfer losses thus the duration for utilization of external wireless unit to charge the implanted rechargeable battery by introducing a unique multimode rectifier circuit charging the load for an extended coupling range and eliminating the requirement of alignment magnets the efficiency loss is reduced and the charging efficiency is maximized in the aria project which stems from the developments within the erc flamenco project we will perform technological and commercial validation of wpdt unit according to the market standards then optimize the unit for fabricating a demonstrator to be integrated to the fici we will also look into the potential for integration with other active implantable medical devices aimds if implemented successfully the aria wpdt not only would be a major step for commercialization of our fici which has already triggered interest of ci makers users and investors but also could lead to new applications of aimds
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the bilingual semantic system sense computational assessment of crosslinguistic meaning representation across cultures
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growing evidence suggests lexical semantics is not universal being shaped by culture and translation equivalents may bear distinct meanings in each language if so how do bilingual brains juggle competing meaning representations for translations sense will investigate the impact knowing a second language has on the native languages semantic system across cultures to do so we will use two recent computational approaches distributional semantic and word association models obtained from linguistic corpora and free association data respectively both methods have shown promising results in predicting human performance in semantic tasks making them ideal candidates to inform psychological theories yet which models better reflect human semantic representation is under debate further few studies in semantic memory research have used these tools while researchers have stressed the need to adopt these methodologies these calls almost invariably have a monolingual scope neglecting the pressing questions bilingualism poses on the nature of the semantic system sense has three overarching goals 1 to assess the role of culture in the construction of meaning by examining the conceptual structure of languages from different primary families spoken in culturally distinct societies spanish turkish chinese english the invariable second language will also be studied 2 to measure bilingualisms impact on semantic representation by investigating how l2 english semantic information integrates into the already established native languages semantic systems 3 to test which models are better suited to account for meaning representation by comparing their predictability of human performance in a battery of semantic tasks overall sense will make a solid contribution to understanding how culture and bilingualism shape the semantic system while helping to establish modern computational techniques in cognitive psychology research
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automated turnkey insect rearing farm enabling farmers to produce their own sustainable insect protein feed
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farminsect responds to the global need for alternative protein sources for animal feed in a sustainable and efficient way for farmersfarminsect is the first insect company to put existing farmer in the center of the solution utilizing bsf larvae in a full closed loop system farmers feed the larvae on organic sidestreams just as natures perfect upcycling machines larvae convert organic residues to create highquality protein to feed animalswith farminsect a livestock farmer can produce up to 1000tnyr of bsf larvae at 800 vs 1350t of fishmeal towards replacing dependency on global markets key to farmers is the healthy value of larvae feed for animals the bsf larvae contain natural immuneboosting peptides that improve the immune system of farm animals insects as feed reduce abnormal behavior such as feather picking in chickens or tail biting in pigsfurthermore added value organic fertilizer is produced as byproduct
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cohesion in particulate media
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how grains flow can we predict the behavior of sand snow powders and more generally of a collection of particles in many situations both in nature or industry this question is of importance to predict avalanches landslides or designing silos and industrial processes while for simple fluids the measure of the viscosity is sufficient to compute and predict the flow for granular materials the question remains open the challenge of understanding the physics of granular flows has motivated many researches and constitutive laws have been developed for grains interacting by friction and collision however in many applications grains present cohesion and predicting their behavior is much more challenging sticky or humid grains powders snow fibers are examples of granular media having difficulties to flow with clogging agglomeration intermittency the cohpa project aims at a fundamental understanding of the behavior of cohesive granular materials by combining experimental numerical and theoretical approaches with the ultimate goal of developping constitutive laws able to predict their behavior in any configuration the two work packages correspond to two types of cohesive materials in wp1 i will study cohesion resulting from the presence of adhesive forces between particles and i will focus on the development of model materials made of sticky grains with tailored surface properties as well as on real powders by developing innovative rheological technics coupled with numerical simulations we hope to get a new understanding of the rheology in wp2 i will study the cohesion arising from entanglement between frictional particles as observed in an assembly of fibers as in a bird nest or a cotton ball or when mixing fibers and grains typically roots in soils they constitute a new class of disordered materials in which the tensile strength results from a subtle coupling between geometry elasticity and friction which is not yet understood
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scilifelab programme for future leaders in life science
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scilifelab pulse is a mscacofund postdoctoral programme of excellence in life sciences coordinated by the swedish research infrastructure scilifelab pulse will recruit 48 postdocs in academic and entrepreneurial tracks that will receive 3 years of international interdisciplinary and intersectoral career training focused on preparing them as impactful leaders in academia andor industry pulse postdocs will be immersed in the internationally recognised scientific community of universities 10 research institutes 4 infrastructures 3 companies 12 and associations 4 providing joint core career and specialised training and access to cuttingedge hightechnology infrastructures that comprise the foundation of scilifelab at the heart of pulse is a wellconceived core training programme augmented by secondments to ensure necessary breadth and tailored individualised training adapted and relevant to academia and industry and to facilitate international scientific exchange the pulse output will be a new breed of scientists wellprepared in the application of highthroughput technologies and datadense analytical approaches and who can confidently meet the emerging societal challenges confronting the european research area specifically in precision medicine pandemic laboratory preparedness planetary biology and drug discovery and development pulse is aligned with the european charter for researchers and the code of conduct for the recruitment of researchers and takes into account the msca supervision guidelines and green charter pulse will have an impact that extends beyond its duration establishing dialogues with multiple stakeholders in the nonacademic sector and by setting new standards in postgraduate research training in life sciences internationally pulse will be administered by the swedish royal institute of technology kth and has an overall budget of 190 meur of which 36 stems from the ec and 64 from participating institutions
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black hole stability
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the discovery of black holes first as explicit solutions of einstein equations of general relativity and later as possible explanations of astrophysical phenomena has revolutionized our understanding of the universe from a mathematical perspective a central issue is to investigate the stability of these fascinating objects this is the focus of the present proposal containing the following work packageskerr stability conjecture this concerns the nonlinear stability of kerr black holes which form a 2parameter family of explicit solutions to einstein vacuum equations it has become since its discovery by r kerr in 1963 a central topic in general relativity first during the golden age of black hole physics and in the last twenty years in mathematical relativity these efforts have led to the recent resolution by the pi and collaborators of the conjecture in the slowly rotating case the goal of this work package is to tackle the general caseblack hole stability with matter breakthrough concerning the stability of kerr for einstein vacuum equations opens the door to other physically relevant cases in the context of einstein equations coupled to matter this work package aims at proving the stability of charged kerrnewman black holes for einsteinmaxwell equations kerr back holes for massless einsteinvlasov equation as well as the stability of kerrde sitter black holes in the case of an arbitrarily small cosmological constantprices law and kerr stability an open problem concerns the optimal decay rate for perturbations of kerr that can be achieved in the kerr stability problem the analogous problem for corresponding linear toy models is known as prices law obtaining an optimal decay rate in the context of the kerr stability problem would not only vastly extend prices law but it is also expected to have important implications on the strong cosmic censorship conjecture concerning the deterministic character of einstein equations
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federated virtual twins for privacypreserving personalised outcome prediction of type 2 diabetes treatment
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virtual twins may be used as prognostic tools in precision medicine for personalised disease management however their training is a data hungry endeavour requiring big data to be integrated across diverse sources which in turn is hampered by privacy legislation such as the general data protection regulation privacyenhancing computational techniques like federated learning have recently emerged and hold the promise of enabling the effective use of big data while safeguarding sensitive patient information in daibetes we build on this technology to develop a federated health data platform for clinical application of the first internationally trained federated virtual twin models our primary medical objective is personalised prediction of treatment outcomes in type 2 diabetes which afflicts 1 in 10 adults worldwide and causes annual expenditures of ca 893 billion eur while healthcare providers are becoming increasingly effective at targeting diabetes risk factors eg diet or exercises no guidelines as to the expected outcome for a given treatment for a specific patient exist to address this urgent yet unmet need the federated daibetes technology will harmonise existing data of ca 800000 type 2 diabetes patients of 4 cohorts distributed across the globe and learn prognostic virtual twin models those will be validated for their clinical relevance and applied in clinical practice through a dedicated software we aim to demonstrate that our personalised predictions have a prediction error that is at least 10 lower than that of population averagebased models this federated virtual twin technology will enable personalised disease management and act as a blueprint for other complex diseases our consortium combines expertise in artificial intelligence software development privacy protection cyber security and diabetes and its treatment ultimately we aim to resolve the antagonism of privacy and big data in crossnational diabetes research
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intelligent multi agent robotic systems
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the imars vision aims to revolutionize emergency services by harnessing ai robotics iot and crossdisciplinary expertise this research program facilitates collaboration among three first responders an industrial sme and four research institutions fostering the exchange of knowledge and personnel across sectors and borders its core impact lies in promoting a holistic problemsolving approach and practical innovation in emergency response through1 multidisciplinary collaboration leveraging diverse fields to create solutions surpassing the limitations of individual disciplines2 knowledge exchange and mobility offering secondments to blend academic and industrial insights ensuring realworld applicability of research3 professional development providing training to develop a skilled workforce ready to deploy advanced technologies in emergencies4 creativity and entrepreneurship cultivating an environment where innovation flourishes potentially sparking new ventures focused on emergency services5 sector interaction ensuring direct involvement of endusers from first responders to industry experts guarantees that developments are usercentric and actionable6 technological advancements imars addresses the full technology spectrum from data acquisition to advanced communication aiming for comprehensive enhancements in emergency operations7 humanitarian focus prioritizing the use of robotics in search and rescue to improve outcomes for society reflects the projects commitment to humanitarian values imars stands to redefine emergency service provision making it more robust and efficient by aligning cuttingedge technology with strategic collaboration imars sets the stage for global advancements in emergency management and could become a benchmark for international cooperative innovation
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developing new antibiotic peptides targeting eskape bacterial trans translation
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antimicrobial resistance amr poses a major threat to human health around the world the amr crisis has emerged as one of the leading public health threats of the 21st century this global crisis is due to the fact that bacteria share and increasingly develop new resistance mechanisms as a consequence of the misuse of antibiotics as well as a lack of new drug development to combat this crisis we need new classes of antibiotics and most importantly against new targets it is therefore crucial to identify new molecular processes that can be targeted ideally these should be i conserved among all pathogenic eskape bacteria ii indispensable to bacterial survival or at least its fitness iii sufficiently variable that different species can be distinguished from each other iv absent in eukaryotes v not targeted by current antibiotics vi unrelated to existing amr mechanisms and finally vii reproducible in non hazardous in vitro experiments in this quest transtranslation appears to be a perfect candidate development of new antibiotics that target transtranslation from multidrug resistant eskape pathogens will be addressed in this project transpeptid we will use engineer antimicrobial peptides based on the c terminal tails of smpb proteins from espake pathogens with the propose to compete with endogenous smpb and in turn to inhibit transtranslation the project is organized in three main objectives that will constitute three major breakthroughs in the field ob1 optimization and characterization of designed peptides in eskape pathogens ob2 biophysical analysis of selected peptides in target eskape pathogens and ob3 determination of the high resolution structures of the complexes between the peptides and their molecular targets by cryoem since transpeptid is a multidisciplinay project that embraces both fundamental and applied science it will contribute significantly to strength the research and training profile of the researcher
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mechanicsaugmented brain surgery
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this project aims at revolutionising the treatment of brain disorders through mechanicsaugmented brain surgery magery due to the ultrasoft nature of brain tissue surgical procedures have exceptionally high requirements for minimal invasiveness and maximal safety during the procedure brain tissue largely deforms and is easily loaded beyond its functional tolerance a promising technology to improve surgical outcomes is to integrate virtual information either through immersed virtual reality vr in training and planning or through augmented reality ar overlaying virtual information with the surgeons real view despite rapid advances to date most vrar solutions have disregarded the complex regiondependent mechanical properties of brain tissue and mechanicsinduced cell dysfunction or death the magery project will follow a new paradigm by focusing on brain mechanics we imply that we can minimise unnecessary brain tissue damage by integrating continuum mechanicsbased simulations into vrar solutions realising this objective will require to combine stateoftheart approaches in live cell imaging nonlinear continuum mechanics and computational engineering the applicant and the magery team will for the first time perform simultaneous largestrain mechanical measurements and multiphoton microscopy and through modelling and simulations identify thresholds for tissue and cell damage under complex threedimensional loadings by merging simulation results and vrar techniques this project strives towards realtime predictions of brain tissue deformation and corresponding damage with her pioneering role in testing and modelling the complex behaviour of human brain tissue the applicant has excellent prerequisites to tackle these challengesif successful this project can not only revolutionise vrar for brain surgery but also leverage our understanding of the cellular response to threedimensional mechanical loading across length and time scales
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education diversity innovation and politics
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the introduction of free and universal education accessible to diverse religious and cultural groups has been a major achievement worldwide and a crucial factor for economic development however still today many countries do not guarantee full access to education religious minorities often face restricted learning opportunities and top educational institutions are being dismantled if they dissent from governments policies the overarching goal of edipo is to study these extremely important phenomena through the lenses of quantitative economic history focusing on france from the 1789 french revolution to the 1900s this was a period of educational reforms key for french and more broadly for european modernization the innovativeness of this proposal is twofold i it constructs groundbreaking micro data from archival and secondary sources of similar quality and detail of modern data but for a longer time horizon ii it identifies unique historical episodes to assess causality and to study the longterm effects edipo is composed of three projects project 1 studies the process of expansion of mass education from its demand to its consequences project 2 asks how discrimination affects schooling choices of religious minorities project 3 documents the impact of dismantling a highquality but dissident educational institution on human capital innovation and political outcomes edipo speaks to economists economic historians and political scientists it sheds light on past and current instances of expansion and secularization of education and it contributes to important public debates eg the importance of achieving universal education the increasing diversity of our society and the discrimination often faced by minority groups and the dismantling of institutions training outstanding but dissident scholars
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better understanding intensified engagement training and development in regional biobased systems
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engage4bio will strengthen circular sustainable bioeconomy and sustainable regional development through engaging quadruple helix actors taking into account their diversity of societal economic and cultural perspectives from five regional biobased systems and five associated regions in processes of design thinking cocreation retraining and skills development based on their regional specificities availability of biomass feedstock level of technology planetary boundaries and social capital activities will be cocreated performed and reshaped to their best advantage for each region the regional biobased systems focus on the five major value chains namely circular and biobased textiles nl agriculture and agrofood industries hu wood and interior at biobased and sustainable packaging fi and blue bioeconomy it the embedding art and design in the activities the framework will boost the uptake to a strengthen local governance feedback loops and respective governance models b to increase design thinking and cocreate formats for training retraining mentoring and skills development and transfer fostering understanding and engagement in biobased systems c to cocreate communication and awareness campaigns the cocreated and implemented activities result in fully open initiatives that advance skills transfer and development activities like re training formats or mentoring programmes for various relevant stakeholders in biobased value chains and encourage the inclusion of citizens knowledge and perception as well as the engagement of citizens boosting a betterinformed decisionmaking process and enhancing engagement and innovation thus engage4bio framework will be designed in a transferable way considering regional natural and cultural differences and will be applicable in different european regions also thanks to the involvement of networks and regions the partners include
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natural deep eutectic solvents for sustainable bioplastics
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petroleumderived plastics produce greenhouse gas emissions ghgs the primary cause of climate change at every single stage of their life cycle on the contrary plant biomass is produced via photosynthesis which involves the transformation of carbon dioxide one of the ghgs water and light into chemical bonds therefore using plant biomass to produce bioplastics removes carbon dioxide from the atmosphere and keeps it stored throughout the products useful life therefore neoplastics aims to valorize highly available lowcost and nonedible lignocellulosic and nonlignocellulosic vegetable waste to prepare bioplastics that represent an alternative to the traditionally used petroleumderived polymers for agricultural and packaging applications specifically this project will study the role of natural deep eutectic solvents nades as facilitators for transforming biomass into bioplastics these compounds are gaining importance as solvents for vegetable waste valorization they are usually used for biomass fractionation and only a few recent works have reported their use in transforming natural polymers into bioplastics by acting either as solvents or as plasticizers these researches represent only a starting point for what it is possible to do with these innovative solvents whose main advantage is that it is possible to tune their physicochemical properties by varying the nature and ratio of their constituents which in turn can lead to a wide range of materials properties for different applications the project introduced here is highly ambitious it will not only provide advantages such as zero waste generation contribution to the circular economy and a low carbon footprint manufacturing process but it will also boost the career of the experienced researcher and enrich the knowledge and experiences of both the researcher and the host institution impacting positively on the scientific community the civil society and the business sector
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link4skills
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link4skills is a global research and innovation project on skill shortages the acronym reflects the objectives of the call by linking for4 fair skill matching it embeds 4 processes of responding to skill shortages reup skilling of established populations incl migrants and inactive women raising wages automation and migration it considers 4 continents europe africa asia and america where skill shortages and skill flows will be analysed it develops the aiassisted skill navigator for stakeholders from employment vocational training organisations in origins and destinations link4skills will scrutinize a how to identify the existing and emerging required skills in changing labour markets b how the eu should respond to skill shortages c how to recruit the required skills from various pools either from the existing workforce including established migrant populations and inactive women also supported by automation and from the workforce from noneu countries the project combines data on skill gaps and matching in the eu with analyses about human capital in origins investigates emerging and established migration skill corridors between eu and india morocco ghana nigeria philippines indonesia and ukraine in order to make enriched inventories of skill partnerships the project achieves its aims via econometric microsimulations based on eu databases combining skill supply and demand and by data collections and stakeholders expertise oversees the knowledge will be nested in the aiassisted skill navigator trl5 which is a knowledgebased expert system that goes beyond existing policy dashboards it is an open access system available to public it is cocreated by labour market stakeholders in every partner country partners will take care about stakeholders involvements in the project by enhancing tailormade communication and dissemination the project will also produce link4skill podcast series and academic outlets
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ultrafast control of interlayer coupling of twodimensional layered materials
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layered twodimensional materials are novel quantum materials considered as the basis for futuregeneration electronics the electronic and optical properties of such materials critically depend on socalled interlayer coupling the interaction between the neighboring atomic layers within the material what is of particular interest is that one can modulate this interlayer coupling and thereby the materials properties by applying an electric field in the outofplane direction of the atomic layers in this project i focus on a typical semiconductor layered material called transitionmetal dichalcogenides tmdc in tmdc bandgap modulation with dc electric fields was recently achieved however the limitation of the modulation speed remains yet unclarified in addition the expected insulatormetal transition at the strongfield limit has not yet been realized because the required strong field causes a dielectric breakdown of the materialthis project aims to 1 realize ultrafast control of electronic properties of layered materials via direct ultrafast manipulation of interlayer coupling 2 identify the speed limitations to this controlling mechanism and 3 realize the insulatormetal transition in the layered material via the ultrafast control scheme to investigate the ultrafast dynamics i will utilize the terahertz technology which enables us to apply a very short pulse of an electric field a terahertz pulse to the material and observe the change of its optical properties in an ultrafast timescale a newly proposed micrometersized device which converts an incident terahertz pulse to a strong outofplane electric field on tmdc will enable ultrafast property controlthe proposed scheme will be applicable for the ultrafast control of quantum phases in various layeredmaterial systems it is also expected to be applied as optoelectronic and alloptical ultrafast switches which are important milestones for future ultrafast technologies
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customized games and routes for cultural heritage and arts
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along with the tourism industry cultural and creative industries ccis are most affected by the pandemic all ccis need systems or management tools to make them more resilient today thus culturati aims to build an inclusive culturaleducational ecosystem with visitor and capacity management by using digital solutions and cuttingedge technologies to 1 enhance and support collaboration between ccis and citizens to promote europes culture values and interests 2 increase accessibility awareness and understanding of cultural heritage and arts 3 preserve cultural heritage by preventing deterioration due to overcrowding and sustain valuable resources 4 enhance the audience experience through customized games and routes by optimizing the number of people on the venue or sitebased ccis ensuring social distancing between them in case of a pandemic culturati is a global content platform that enables ccis creative professionals and citizens to create content collectively for cultural heritage and arts across europe consequently culturati curates content in its database and delivers customized information with the help of its algorithm therefore the principal objective of the culturati project is to design develop evaluate and validate mainstream technologies for its ecosystem utilizing the internet of things cloud and mobile technologies sensors people counters and artificial intelligence our usercentered design methodology situates user needs at the center by actively involving them in five pilot sites across europe to validate culturati as well as increase engagement with broader audiences accordingly our interdisciplinary consortium involves computer scientists ccis academia from various disciplines including social sciences smes public authorities and nonprofit community initiatives to focus on engaging citizens and ensuring widespread communication and exploitation of culturati in europe and internationally
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adaptive redox regulation in inflammatory macrophages
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macrophages are key players of the innate immune system and as such maintain homeostasis initiate inflammatory and redox responses for pathogen defence but also regulate resolution of inflammation supporting these functions are distinct metabolic programmes which underlie macrophage functional phenotypes while recent advances have improved the understanding of macrophage metabolic programmes supporting specific activation states it remains unclear how the redox system is regulated in macrophage activation states and during pathogen defence here i propose to investigate how redox adaptation is regulated during macrophage activation and its impact on functional phenotypes i will focus on the following three aims firstly i will quantify expression of cystine transporter slc7a11 which by importing cystine supports glutathione and coenzyme a synthesis this will allow a better understanding of the role of cysteine during redox adaptation in comparison to the wellknown heme oxygenase 1 ho1 secondly i will disrupt key regulators of redox adaptation including slc7a11 and ho1 to investigate their effect on macrophage functional phenotype this will identify key nodes for redox adaptation in different macrophage activation states thirdly i will investigate the temporal profile of electrophilic stress and redox adaptation in response to macrophage activation and during bacterial infection overall this project will contribute to the detailed understanding of redox adaptation during macrophage activation which is essential for pathogen defence and protection from oxidative stress furthermore identification of new drug targets for redox regulation in macrophages would provide the basis for novel therapies for oxidative stress induced pathologies
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