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machine learning for autonomic system operation in the heterogeneous edgecloud continuum
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mlsysops will achieve substantial research contributions in the realm of aibased system adaptation across the cloudedge continuum by introducing advanced methods and tools to enable optimal system management and application deployment mlsysops will design implement and evaluate a complete framework for autonomic endtoend system management across the full cloudedge continuum mlsysops will employ a hierarchical agentbased ai architecture to interface with the underlying resource management and application deploymentorchestration mechanisms of the continuum adaptivity will be achieved through continual ml model learning in conjunction with intelligent retraining concurrently to application execution while openness and extensibility will be supported through explainable ml methods and an api for pluggable ml models flexibleefficient application execution on heterogeneous infrastructures and nodes will be enabled through innovative portable containerbased technology energy efficiency performance low latency efficient resilient and trusted tierless storage crosslayer orchestration including resourceconstrained devices resilience to imperfections of physical networks trust and security are key elements of mlsysops addressed using ml models the framework architecture disassociates management from control and seamlessly interfaces with popular control frameworks for different layers of the continuum the framework will be evaluated using research testbeds as well as two realworld applicationspecific testbeds in the domain of smart cities and smart agriculture which will also be used to collect the systemlevel data necessary to train and validate the ml models while realistic system simulators will be used to conduct scaleout experiments the mlsysops consortium is a balanced blend of academicresearch and industrysme partners bringing together the necessary scientific and technological skills to ensure successful implementation and impact
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solving holographic cfts through the synergy of integrability and conformal bootstrap
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this proposal will develop innovative methods to access for the first time at non perturbative level the conformal field theory data of the two holographic conformal field theories that provides the bestestablished paradigms of the adscft correspondence n4 supersymmetric yangmills sym and abjm this goal can be obtained combining the techniques of the conformal bootstrap both in its analytical and numerical approaches with integrability such methods proved to be very efficient when applied by themselves and their complementary usage is the main novelty of this project considering that integrability provides a set of conformal data the scaling dimensions the plan is to use this piece of information as an input for the conformal bootstrap to compute the remaining set of data structure constantsa strongly interdisciplinary approach combining analytical and numerical conformal bootstrap together with the most advanced integrability methods will be adopted to overcome the existing difficulties and compute those quantities this will be possible thanks to the critical convergence of the expertise of the two supervising mentors and the researcher on different aspects of bootstrap and integrability a crucial role will be played by novel techniques developed in recent years by the researcher the new methods resulting from this action are expected to have a wide applicability allowing the study of general correlation functions and to lead to quantitative answers to outstanding questions on adscft the training plan is designed to boost significantly the researchers scientific skills as well as his teaching abilities with the delivery of two phd level courses the action involves a strong dissemination and outreach plan including scientific divulgation a public lecture and the creation of a websiterepository hosting permanent openaccess resources for the scientific community which will greatly facilitate further studies of holographic theories
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optical 6g cell free networks
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the opti6g project develops a photonic near ir cell free 5g network which does not suffer from interference because of the propagation characteristics of em waves in this part of the spectrum and provides universal broadband coverage within buildings from pervasively located owc access pointsthe benefits of applying cell free near ir networks in buildings are 1 multiconnectivity can be configured with cell free network thereby improving link quality and reliability 2 there is no longer the need for building owners to subdivide their nonpublic mobile building network into cellular areas 3 building owners no longer need to request permission from mnos to use their licensed spectrum since the system operates at the optical unlicensed bands 4 interference between inside and outside access is managed by an ai based distributed scheduler 5 position and orientation of end user equipment can be measured very accurately it provides solutions to two main barriers to develop this challenge i brings together a select multidisciplinary team of research institutions and industries in a collaborative project to develop and demonstrate this vision who otherwise would not have assembled to achieve this goal ii develops a proof of concept demonstrator in oledcomm and runel ii performs experiments to measure position and orientation of end user equipment at uvsq and ubruthe starting point is 1 stateoftheart cell free 5g ran solution and very high accuracy sub cm accuracy localisation measurement system developed by runel 2 the state of the art vcsel infrared source and highspeed pin photodiodes receivers and that supports 1 gbps data rates up to 5 m over a field of emission of 25 developed by oledcommthe project brings together these technologies to produce an easy installation and operation license free broadband network for indoor buildings the outcome will be lowcost commercially attractive broadband cellular access within buildings
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autoadaptive neuromorphic brain machine interface toward fully embedded neuroprosthetics
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nearly 746000 people sustain a spinal cord injury every year with dramatic human societal and economical cost leading to impairment or even complete loss of motor functions motor brainmachine interfaces bmis translate brain neural signals into commands to external effectors bmis raise hopes that limb mobility may be restored providing patients with control over orthoses prostheses or over their own limbs using electrical stimulation in spite of spectacular results taking neuroprosthetics into daily practice has proven difficult currently neuroprosthetics are restricted to assisted trials in laboratories and require regular retraining of a decoder in a supervised manner within controlled environments they include various components recording device antennas base station computers connected to effectors etc that are complicated to install and to use building on the consortiums unique experience in clinical chronic bmis the project will address major methodological and technological breakthroughs to achieve the first assistancefree motor neuroprosthetics system nemo bmi project will conduct the exploration of assistancefree and easy to use portable neuroprosthetics including wireless neuronal activity recorder a realtime neuronal activity decoder based on integrated technologies and a spinal cord stimulator a first objective is the crucial improvement of usability by introducing an autoadaptive framework to train the decoder in an adaptive manner during the neuroprosthetics unsupervised use brainguided spinal cord stimulation activating patients limbs with an automatic stimulus pattern optimization is the second project objective a third objective is the exploration of miniaturized embedded solutions by taking advantage of a novel neuromorphic hardware architecture nemo bmi technologies will be studied offline and online in two ongoing clinical trials and will be critical to specify the nextgeneration assistancefree bmi
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decoding the rules of enhancer promoter specificity throughout development
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enhancers control spatiotemporal gene expression which is central to the diversification of celltypes and tissue differentiation enhancers can be located in close proximity to or distally from their target genes promoters including in introns of noncognate genes to regulate gene expression distal enhancers e must come into proximity to interact with their promoters p through foldinglooping of the intervening dna how enhancers identify and regulate their specific target gene remains poorly understood and is subject of this proposal chromosome conformation capture based techniques such as nucleartitrated nuti capturec are powerful tools for the genomewide investigation of enhancerpromoter proximityinteractions epis at subkilobase resolution this project aims to uncover general features of epis by measuring and characterizing epis using nuti capturec across many different developmental stages and tissues during drosophila embryogenesis i will analyze a massive capturec dataset already generated by host lab capturing interactions from 16663 genes promoters each at eight different conditions with four replicates thereby providing unprecedented scale and resolution i will integrate this capturec resource with multiple genomewide datasets gene expression histone marks and chromatin accessibility from the host lab and others the analysis of this comprehensive epis atlas will link enhancers to promoters genomewide characterize features driving ep specificity and potentially identify novel factors involved in their establishment this new view of tissue and developmental stage specific epis will serve as a unique resource that we will share through a userfriendly webbased portal to a large community using this important model organism the biological insights that we uncover including features linked to ep specificity and tissuesspecific regulation will interest a very broad community studying genome regulation
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development of newtonature reactions under the concept of synergistic catalysis through the design of novel cobaltbased artificial metalloenzymes
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artificial metalloenzymes arms that is designed enzymes containing a synthetic metal cofactor within a protein framework locates itself as a promising area of research for the discovery and development of new transformations we set our attention in cobalt complexes as cofactors a firstrow earthabundant and nontoxic metal that is currently underexplored in arms cobalt complexes present a highly versatile chemistry including they ability to participate in allylic functionalization reactions an important transformation for the pharmaceutical industry as can deliver structural frameworks that are widely spread in biological active compounds allylic functionalization reactions are underdeveloped in biocatalysis and the expansion of important homogeneous reactions as the before mentioned into the realm of enzymes is an absolute necessity for the development of sustainable chemistry coarms cobaltcontaining artificial metalloenzymes proposal aims to create new generations of arms relying on the unique reactivity of synthetic cobalt complexes in allylic substitution reactions an unknown reaction in enzyme catalysis and an underexplored metal for the discovery of newtonature reactions the proposal balance between host expertise dr gerard roelfes in bioinorganic and chemical biology and the researchers skills dr franco dellafelice in synthetic organic chemistry the result is a cooperative field where two different branches converge with the aim to develop new concepts and environmentally compatible tools in chemistry to access organic frameworks of high significance to the pharmaceutical and agrochemical industries
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fuel cell propulsion system for aircraft megawatt engines
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green hydrogen as a fuel offers the possibility to significantly reduce or even eliminate all of aircrafts greenhouse gas emissions when liquid hydrogen lh2 is used in fuel cells fc for power generation this results in no co2 no sox and no nox emissions the best way to achieve this solution is to develop a hydrogen propulsive fc system as an integral part of a new lh2 aircraft concept this means moving away from the current plug and play separate motor development and aircraft architecture philosophy towards a disruptive integrated way of development which requires a cocreation approach of the propulsion system and the aircraft fame follows this approach by collaborative research and development between on one hand partners involved in development of the needed systems of the fuel cell and on the other hand airbus as and aircraft designer manfacturer und integrator thereby it is ensured that on all levels from material over component and subsystem up to propulsion system on aircraft level an optimization is realized the focus of fame is on developing a complete compact highefficiency full electric propulsion system based on lh2 as energy source for short to medium range smr aircraft fame will develop all the subsystems which are needed and integrate these in a mw fc propulsion system ground demonstrator with the vision to scale it up to aircraft level sufficient for smr aircraft fame shows the feasibility of a multimw fc propulsion system for hydrogenpowered smr aircraft the system will provide the basis for clean aviation in phase 2 to undergo a system flight test
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biomimetic sensorized barriersonachip unveiling a new generation of marketready investigation tools
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the lack of reliable in vitro preclinical models represents a critical aspect unanimously recognized by the scientific community as detrimental in the pathway of bringing new medications from the laboratory to the bedside addressing this issue would provide immense benefits to drug discovery and development processes by ethically limiting animal testing and drastically reducing costly failures in clinical trials to date most in vitro models fail at recapitulating the physiological microenvironment and this often results in misleading data withdrawal starting from my prototype of real scale dynamic and biomimetic bloodbrain barrier model in this project i aim at the validation of my system after an upgrade step consisting in embedding sensing features in the platform thus allowing a realtime evaluation of barrier formation and integrity maintenance characterized by microcapillary sizefenestrations and fluid flows similar to the in vivo physiological barrier my tool will represent a drastic innovation over other wellestablished models in the literature and available on the market allowing a reliable reproduction of the physiological environment and an accurate estimation of the amount of drug andor nanomaterial concentration delivered through the barrier validation will be performed in relevant conditions by implementing stroke and brain cancer models all artificial components will be fabricated through twophoton polymerization 2pp a disruptive mesoscale lithography technique that allows the fast fabrication of lowcost structures with resolution up to the nanometer scale as well as great levels of scaffold reproducibilityaccuracy the proposed platform can be easily adopted in research laboratories and pharmaceutical industries as an advanced preclinical model the primary biomedical applications of which consist in reliable screenings of drugs against pathologies of the central nervous system
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chiral metalbased luminophores for multifield responsive bistable switches
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the lumifield project concerns the development of smart materials for miniaturized and efficient electronic magnetic and optical devices such as data storage systems this issue will be addressed by the design of multifunctional systems presenting a broad range of properties generated in a single phase that will enable switching of optical effects by a magnetic field h an electric field e and electromagnetic radiation light i propose an intensive research program aimed at crossing the current limits of singlephase multifunctionality i plan to use chiral metalbased luminophores cls interacting with unpolarized light to produce photoluminescence pl and circularly polarized luminescence cpl molecularlevel functionalization of cls will lead to a combination of plcpl phenomena with singlemolecule magnetism smm ferroelectricity and a photoswitching property the resulting systems i magnetic cls ii ferroelectric cls and iii photoswitchable cls will show the related bistabilities detected by the plcplbased optical response also ensuring overall responsivity to the h and e fields and light the ultimate aim is to construct a multifunctional clswitch bearing at least two properties from the set of smm ferroelectricity and photoswitchability it will open a gateway to a multistate memory effect induced by dual or triple physical stimuli with the plcpl output the project will focus on searching and optimization of the chemical route to multifunctional switches as well as on physical experiments elucidating the hfield efield and lightmatter interactions in cls therefore the final results of the project might include a multifield responsive system suitable for highdensity data storage operated by various physical stimuli the formulation of general rules for the external control of pl and cpl effects in metal complex systems and the formation of a highly qualified research team to face the future challenges for the eu
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remanufacturing network
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in the current complex socioeconomic situation european producers face challenges posed by a growing scarcity of raw materials and goods fluctuating costs and unpredictable delivery times according to the eu agenda they must contribute to reducing the environmental impact of manufacturing processes to prevent climate change and to achieve zero carbon emissions thus the only sustainable option is to rethink the life cycle of goods and search for new approaches to give new life to end of life eol products grounding on this vision the remanet project aims to enable a widespread diffusion of the concepts of remanufacturing recycling material saving and functional upgrading by implementing a factoryintegrated digital platform able to extend the remanufacturing value chain the main project goal is to establish a new remanufacturing business model by creating a community where different actors can make available their specific knowhow and contribute to any step of the remanufacturing process to achieve this goal multiple digital tools will be developed on the remanet digital platform horizontal tools will help matching supply and demand also providing secure data sharing to spread the needed competences in terms of human resources or digitized formalized knowledge vertical tools will enable the integration of shopfloor and process data with advanced tools for monitoring prognostics and full traceability of material and information flows as well as cutting edge remanufacturing technologies the digital platform will provide a standard for manufacturing and remanufacturing with an integrated and easytouse infrastructure fostering a reliable and secure data flow access and use at all levels from shopfloor and further along the value chain the proposed business model and digital solutions will be validated in five use cases ranging from automotive to mold and dies and to the energy sector and its decarbonization
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development of novel viral vectored vaccines against marburgviruses inducing robust and crossreactive protection
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the frequency magnitude and geographical range of marburg virus disease outbreaks are expanding with recent cases emerging in equatorial guinea and tanzania marburgviruses listed among the who priority pathogens have demonstrated their epidemic potential however no licensed vaccines are available and outbreaks continue to impose high morbidity and mortality burdens vaccine candidates in the pipeline are based on the marburg virus marv glycoprotein gp as a single immunogen marvax ambition is to improve the strength and breadth of marv vaccines by deploying the measles virus mv and modified vaccinia virus ankara mva viral vector vaccine platforms for expression of several marv antigens gp viral protein 40 vp40 which together with gp allows the formation of viruslike particles and the nucleoprotein np which contains conserved epitopes that are the main drivers of t cell responses we will evaluate in depth the innate adaptive and memory antigenspecific humoral and cellular crossprotective immune responses induced by mvmarv and mvamarv vaccine candidates against marv ravn virus and ebolaviruses in single dose and in homologous and heterologous primeboost immunization regimens through an innovative preclinical testing pipeline we will use cuttingedge and novel in vitro primary human cell cocultures and immunocompetent mouse models to evaluate immunogenicity chimeric and avatar mouse models to evaluate immunogenicity and efficacy and identify correlates of protection and the highly relevant cynomolgus macaque model to evaluate safety immunogenicity and efficacy furthermore gmp batches of the best vaccine candidates will be produced by the end of the project towards their future evaluation in a phase i clinical trial in collaboration with the wholed initiative for prioritization and acceleration of clinical trials of marburgvirus vaccines in atrisk and healthcare communities and upon outbreaks
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advanced nanospectroscopy for mapping local conductivity in conductive metalorganic framework
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napoleons main objective is the development and demonstration of mapping ultrabroadband optical conductivity of novel conductive metalorganic frameworks mofs by infrared nanospectroscopy nanoftir conductive mofs are critically important for the development of a highly efficient and low cost electrocatalysis for electric energy storage and retrieval mofs development needs the understanding of its conductive properties down to the nanoscale which is not possible with traditional electrical transport measurements nanofitr offers several advantages compared to traditional transport measurements no contacts are needed there are no problems with contact resistances nanoscale materials can be measured and the frequencydependent response provides deeper insights into conduction properties than just dc measurements however current tabletop nanoftir systems are not able to characterise conductive mofs due to the limited spectral coverage of the employed laser sources to overcome this challenge i will introduce a novel plasma sourcebased nanoftir spectrometer which will ensure the broadest spectral coverage then i will develop a new model from which the anisotropic conductivity of mofs can be extracted from nanoftir spectra finally i will use the improved nanoftir system and the new model to study a highly conductive mof sample the cubht which demonstrated high electrocatalytic activity napoleon will provide innovative technologies original methods and breakthrough knowledge in the fields of chemistry nanooptics and solidstate physics specifically napoleon will develop the first methodology to measure optical conductivity in conductive mofs with nanoscale resolution which will contribute to boost the development of these materials the results envisioned by napoleon in terms of characterisation and understudying of new materials for electrocatalysis will be a key piece to achieve the eu target of carbon neutrality by 2050
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photonic and electronic integrated circuits for nextgeneration lidar technologies
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lidar or light detection and ranging technology is popping up everywhere industry experts are predicting an evergreater enabling role for lidar in everything from advanced driving support systems to autonomous driving to autonomous mobility applications to gas sensing etc the demand for the technology is at an alltime high and it is expected to experience a steadily accelerating adoption across markets nitelidar will break new ground in lidar technology by allowing higher levels of integration including optical phased array based solidstate beam steering and onchip frequencymodulated continuouswave based ranging thus moving away from mechanical components which will bring down the cost of lidar to achieve this nitelidar will leverage on beyondstateoftheart knowledge being generated around photonic integrated circuits pic and electronic integrated circuits eic while addressing current gaps and tackling the paucity of knowledge around the largely underexploited lidaronachip technology nitelidar therefore creates a platform solution vouching for the european leadership in nextgeneration lidar technologies the mission of nitelidar is to train 10 doctoral candidates dcs with outofthebox thinking and an entrepreneurial mindset in the field of lidar technologies as a specific expertise and photonic and electronic integration ie semiconductor skills and expertise in a broader perspective which are key for the implementation of the eu chips act and wider for the european semiconductor autonomy
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boosting the efficiency of skin thermoelectrics by developing stretchable nanocomposite substrates with tunable anisotropic thermal and electrical conductivity
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as the world is rapidly adopting wearable technology the demand for efficient selfpowering devices is becoming increasingly critical thermoelectrics tes are important because they can convert body heat directly into electrical energy to power wearable electronics and enable efficient onskin heatingcooling for applications such as skin thermoregulation existing wearable te devices inevitably face reduced energy conversion efficiency due to 1 high contact thermal resistance at the interface between the substrate and the skin due to nonconformal contact and poor attachment 2 high parasitic thermal resistance across the substrate which is typically a thermally insulating flexible polymer and 3 high electrical contact resistance between the te legs and their interconnects due to a poor electromechanical interface in besttec i target a 3in1 solution to these challenges by proposing novel skinlike nanocomposites with high mechanical compliance and tunable heatelectrical transport across preferential directions used as a substrate for skin thermoelectric ste devices these nanocomposites will result in a tenfold increase in performance besttec is innovative because while most ste research to date has focused on the development of new materials and device architectures besttec addresses a largely overlooked aspect that is currently holding back device performance the substrate and its interfaces the project is timely because it will enable new wearable biomedical devices needed more than ever in our aging population as the project lead i possess a robust background in wearables nanotechnology and device engineering my customized devices have been used on diverse surfaces such as marine animals and human skin new racing cars and drones underscoring my ability to deliver versatile impactful solutions with an understanding of the challenges faced by ste devices i aim to pioneer the advancement of the field
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local addressing of topological interacting systems
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the latis project builds on the latest advances in addressing individual atoms and engineering topological band structures in optical lattices in view of exploring the rich physics of interacting topological matter with unprecedented control ultracold topological matter has recently emerged as a central theme in the realm of quantum gases by manipulating ultracold atoms in optical lattices various experimental groups have realized a variety of topological band structures and detected their characteristic features creating topological matter with ultracold atoms offers a novel view on intriguing phenomena initially discovered in the solid state but also allows for the realization of exotic states that are inaccessible in real materials this quantumsimulation approach to topological matter generates a constructive synergy between theoretical developments driven by curiosity and concrete technological applications until now ultracold topological matter has been explored in the noninteracting regime of quantum gases so that the observed quantities are associated with singleparticle states however exciting avenues would become accessible upon combining engineered band structures with tunable interactions this scenario would provide a concrete path towards the experimental realization of stronglycorrelated topological states in ultracold gases a promising path to create and address such states consists in manipulating a very small ensemble of atoms within a few lattice sites of an optical lattice as now made possible by quantum gas microscopes this setting would allow for unprecedented control over stronglycorrelated topological matter hence offering a unique framework for manybody quantum physics the results emanating from the latis project will have a substantial impact on a wide scientific community working on quantum geometry and topological states of matter with direct consequences for ongoing experiments on synthetic topological systems
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healthy working environments for all ages an evidencedriven framework
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the wage project will develop and validate the first comprehensive framework for assessing and understanding the roles and interactions between physical and psychosocial risk factors across age groups through robust modelling and policyrelevant evidence gathering through the proposed framework the project will pave the way for designing implementing and validating effective multilevel intervention strategies and policy changes for workers of all ages at the individual and organizational level the project focuses on a question that has high societal relevance and is timely because the proportion of employees under adverse physical and psychosocial work environments is likely to increase as organisations businesses and workers have to adapt to postpandemic working environments in an ageing europewage is proposing a concept that is addressing the factors related to the health and overall wellbeing of workers across age groups one of the main aims of the proposed action is the generation of integral policyrelevant evidence that are vital for the improvement and update of occupational health but also for this horizon europe call in wage the gathering and utilization of evidence within decisionmaking spaces will be based on representation and accountability of policymaking bringing multiple perspectives and knowledge through democratic participation into decisionmaking processes across the project from data collection and management to analysis and implementation
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mechanisms of soil restructuring by bacterial aggregates towards a more efficient and resilient agriculture
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soil bacteria are of critical importance to soil health soil poresize distribution over multiple length scales which facilitates nutrient transport depends on the presence of soil aggregates cohesive organomineral assemblies formed by bacterial activity aggregates support plant health and increase soil stability although restoring aggregate structure in degraded soil can yield great benefits for extremeweather resilience and agricultural productivity we lack any mechanistic understanding of how aggregates are formed by bacteria this knowledge gap hampers the deployment of promising bioaugmentation strategies for soil restoration such as inoculation of soil with aggregatepromoting bacteria the objective of agrigate is to narrow this gap by elucidating the biophysical mechanisms of bacterial aggregateformation i will focus on the reciprocal mechanical interactions between bacteria and soil grains using interdisciplinary methods over multiple spatial scales i will first develop a novel microfluidic chip granting realtime optical access to bacterial dynamics inside a threedimensional bed of model soil grains agrigates hypotheses are that 1 there exists an optimal grain size and inoculant richness for bacterialed aggregation and 2 that bacterial extracellular polymeric substances eps are necessary for aggregation i will test these hypotheses by varying grain size inoculant richness and bacterial epsproduction in the chip microfluidic experiments will be combined with experiments in bacterialoaded soil columns observed by xray tomography to extend results to the macroscopic scale and link microscale structure to macroscale function the search for optimal aggregation conditions will be formalized mechanistically and extended by a numerical model of bacterial colony growth in a cohesive granular medium together agrigates new tools and results will provide a strong basis for fundamental and applied studies on soil bioaugmentation
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memristive devices based on conductive metal organic frameworks
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electrolytegated redox transistors are an emerging type of device that has been gaining traction in neuromorphic computing research mostly based on organic polymeric mixed conductors thinfilm redox transistors exploit the soft nature of polymers to swell and accommodate gating electrolyte ions that modulates electrical current in the transistor channel although key to redox transistor operation ion uptake is associated with extensive swelling causing structural changes in the polymeric thin film that are detrimental to thinfilm electrical properties limiting device lifetime and reproducibility conductive metalorganic frameworks cmofs have been gaining more and more interest as smart functional materials cmofs are highly crystalline porous materials comprising metalorganic ligand pairs that determine their structural electrical as well as other functional properties these find application in electrocatalysis battery and supercapacitor technologies cmofs intrinsic porosity offers welldefined ionic pathways that should allow ion uptake without structurally affecting the holeelectronconducting properties of the thin film moreover cmofs have larger charge storage capacity than their polymer counterparts promising a higher number of memory states per device which will result in an exponential increase of computational power memof aims at building memristive devices based on conductive metal organic frameworks that can surclass stateoftheart polymerbased redox transistors in terms of device stability and performance the major challenge of the project lies in synthesizing lowdefect cmof thin films through directed epitaxial growth on functionalized surfaces thanks to my expertise in the characterization of mixed conductors and transistor fabrication and the training in mof chemistry and crystal engineering provided by prof martrujas i aim to obtain robust redox transistors for neuromorphic computing
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design and engineering of optoelectronic metamaterials
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one of the promises of the combination of quantum mechanics and nanotechnology is the ability to design materials with tailormade physical properties while there have been several successful examples as in the case of metamaterials for photonic applications where colour and refractive index can be tuned by a smart design of the material structure the development of similar metamaterials for other applications has been lagging behind in this proposal i aim to capitalize the body of work done by my group to fabricate optoelectronic devices with colloidal semiconducting quantum dots and layered metal halide perovskites by proposing an innovative approach towards optoelectronic metamaterialswe will engineer metamaterials for optoelectronic in the visible and near infrared spectral range using as building blocks superlattices quantum wells qws based on layered metal halide perovskites and pb chalcogenides quantum dots qds respectively the metamaterials will be assembled from a solution phase using modified langmuirblodgettschaefer techniques both for the qws and qds we will increase the monodispersity of the precursors clusters in solution using interaction with an ionic liquid ligands will be used in both qds and qws superlattices to control the charge carrier transport of the metamaterials providing their full tuneability of properties that will allow to revolutionize the optoelectronic field the final certification of the quality of the deoms metamaterials will be obtained with the fabrication of near and shortwavelength infrared photodetectors and visiblelight emitting diodes of superior performance levels
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understanding under uncertainty symbiotic relations between the storyline approach and the philosophy of scientific understanding
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in the last decade the storyline approach has been introduced and developed in the subfield of attribution and detection in climate studies in spite of its merits it has been met with harsh criticism especially from advocates of probabilistic approaches the overall aim of un3 is to explore and exploit the symbiotic relations between the storyline approach and the philosophy of scientific understanding to foster the legitimation of the former and advance internal philosophical debates in the latter un3 is organized into three research work packages with a specific objective wp1 investigates the factivity of storylinebased understanding its specific objective is to characterize and evaluate storylinebased scientific understanding emphasising its complementarities with and divergences from probabilistic understanding particularly in terms of their factivity wp2 investigates the effectiveness of storylinebased understanding its specific objective is to assess the effectivenessfactivity ratio of storylinebased understanding in successful decisionmaking under deep uncertainty particularly in terms of informing robust andor adaptive strategies and exploiting their relations wp3 investigates the transdisciplinarity of storylinebased understanding its specific objective is to identify characterize and develop transdisciplinary means in which storylinebased understanding may be advanced by local knowledge and in turn advance epistemic justice in climate science particularly in terms of conveying actionable knowledge the overall methodology is inter and transdisciplinary involving theoretical and empirical components and including collaborations with academic researchers from various centres and with nonacademic stakeholders un3 will be conducted at politecnico di milano with prof giovanni valente as supervisor and prof massimo tavoni as cosupervisor a secondment is planned at tu delft with prof behnam taebi as host
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highperformance computational photochemistry and spectroscopy
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the future of modern sustainable technologies lies in the exploitation of solar energy and in harnessing the suns practically infinite energy for fundamental as well as targetoriented research in this direction computer simulations of the ongoing photochemical processes and electronic spectroscopy of the underlying molecular materials are indispensable while for smaller molecules computational photochemistry can nowadays provide highly accurate results and reliable predictions the limit in applicable molecular system size is quickly reached and the obtained results often come with an unpredictable error requiring a posteriori validation indeed we are lacking efficient and sufficiently accurate and reliable excitedstate ab initio methods reaching out for organic molecular systems with more than 500 secondrow atoms in hipercops we aim at closing this gap by deriving highly efficient and genuinely parallel ab initio methods for the calculation of excited electronic electrondetached and electronattached states for execution on modern highperformance computer architectures whose full potential is impossible to leverage by existing standard quantum chemical program packages to address this problem we choose the algebraicdiagrammatic construction adc family of methods since these schemes offer clear advantages for instance numerical stability easy to use predictable accuracy we will exploit novel genuinely parallel concepts and solution strategies for adc schemes to enable them for hpc architectures our developed methods and resulting easytouse software will thus push the boundaries of accurate and predictable computational photochemistry to unprecedented molecular system sizes enabling and promoting research in for example the areas of functional optoelectronic devices and photovoltaics molecular solar thermal energy conversion solardriven nanomachines towards efficient molecular harnessing of sun light
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engineering b cells to fight cancer
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b cells have an important role in the immune response against cancer tumor specific b cells in tertiary lymphoid structures and antitumor antibodies in the plasma are associated with a favorable prognosis and with an improved response to checkpoint inhibition in different sarcomas and carcinomas antigen specific b cells home to tumors and prolong survival in mice while b cell based vaccines allow durable antitumor activity in cervical cancer patients we have recently demonstrated both ex vivo and in vivo b cell engineering for the expression of antihiv antibodies here we propose a novel cancer immunotherapy approach based on engineered b cells in particular we use crisprcas9 and aav to target the integration of antitumor antibody genes into the igh locus in diverse tumor models we plan to demonstrate localized b cell activation upon antigen engagement the b cells will exert multiple antitumor effects secreted antibodies will induce adcc cdc and adcp in addition a polyclonal t cell response with epitope spreading will be facilitated by engineered b cells acting as apcs as well as by antibodies forming immune complexes to be taken up by dendritic cells and macrophages for crosspresentation the b cell will be coengineered to locally secrete additional immune effectors upon activation these include stimulatory cytokines bites checkpoint inhibitors cd4027 agonists and cell penetrating nanobodies localized secretion is predicted to increase efficacy while reducing systemic toxicities when targeting selfantigens b cells will be engineered to coexpress a car relaying cd40 or tlr signals for t cell independent b cell activation and allowing allogeneic therapy we will further demonstrate in vivo b cell engineering for increased scalability and ensure safety using a suicide cassette for inducible b cell elimination b cell engineering is thus a flexible and robust platform technology that may revolutionize cancer immunotherapy
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cooperative robotics powered by ai and data for flexible production cells
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the highmix lowvolume hmlv market scenario requires constant changes in jobs materials and machines this implies the need to build highly flexible and intelligent manufacturing environments that allow a fast adaption of processes and systems to changing conditions assuring high product quality with lower production costs and energy consumption this urges manufacturing industries to redefine their production processes for competitiveness and sustainability most of the manufactured components have joints so welding technologies are identified at european level as key enabling technologies for the development of innovative and sustainable manufacturing processes among welding technologies arcbased accounted for 36 of the total in 2020 highlighting its relevance for major european industries traditionally robots have been used in mass production industries performing repetitive tasks at acceptable cost and quality levels sacrificing flexibility for productivity the cooperation of multiple robots powered with ia and data technologies offers new operational capabilities in terms of manoeuvrability and manipulability in several industrial processes corob proposes the development of a smart cooperative multirobotic system for flexible and reconfigurable manufacturing to cover hmlv industrial production needs in the current technological context of industry 50 the system will be humancentered and will integrate advancements in robotics inspection monitoring control and ai developed by consortium partners and 15 external third parties through an open call the flexible solution will be validated in 2 semiindustrial pilots for automotive sector multirobot cooperative arc welding and toolmaking industry multirobot cooperative waam wire arc additive manufacturing for repairing it will contribute to resilience resource saving circular economy cost savings and digital supply chain fostering european industrial competitiveness
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the role of the gut microbiome in host responses to environmental variation within and across generations and species
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the gut microbiome is strongly linked to health and sickness a current key challenge is to understand how the microbiome helps the host adapt to environmental variation yet most research originates from few laboratory animal models and thus misses large parts of environmental physiological and lifehistory variation while data from wild populations and species is needed thus our overarching aim is to unravel how the microbiome mediates hosts responses to environmental variation covering molecular to evolutionary scale using wild birds as a study system we focus on how gut microbiome helps hosts to cope with temperature variation given the pervasiveness of temperature as a challenge across taxa and climatecrisis driven thermal challenges the objectiveso1 to study the role of the microbiome in mediating host adaptive reversible thermal plasticity in adulthoodo2 to assess the role of the microbiome in mediating host adaptive developmental and transgenerational thermal plasticity and explore the underlying epigenetic changes o3 to quantify the contribution of host genetic variation and the microbiome on host thermal physiology o4 to explore the macroevolutionary patterns of microbiome and host thermal physiology o5 to examine the underlying molecular mediators of hostmicrobiome interactionsto understand the causal role of microbiome we apply stateoftheart methods incl microbiome transplants within and across populations o1 and generations o2 and identify the molecular mediators incl bacterial vesicles o5 many tools adapted from the biomedical field to ecoevo research we further use quantitative genetics reaction norms selection lines o3 and multivariate phylogenetic models o4 rarely used in hostmicrobiome field opening new lines of research we produce groundbreaking findings on the microbiomemediated mechanisms of phenotypic variation which helps to predict how organisms respond to anthropog
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commercialising a smart cardiac implant platform for the treatment of chronic cardiovascular disease
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every year chronic cardiac disease causes 39 million deaths in europe thats a death every 8 seconds overall chronic cardiac disease is estimated to cost the eu 210 billionyr in direct healthcare costs all chronic cardiac disease patients are at high risk of stroke atrial fibrillation or heart failurethe aurigen platform is single minded in its focus on the leading causes of death in the developed world cardiovascular diseases allowing more complex patients to be treated more effectively and at a lower cost per patientaurigens platform of 4 devices is built around our custom cardiac implant to which we can add synergistic modules such as cardiac monitoring ablation or both modules creating devices which are much more than the sum of their parts this our key usp allowing aurigen to efficiently effectively manage the most expensive suboptimally treated patients in a single safe fast minimally invasive procedure
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air traffic control trajectory based operations
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the air traffic control trajectory based operations atctbo project proposes to validate tbo sesar solutions for flights in the tactical execution phase for enroute and tma operations thus contributing to the finalisation of the sesar phase c developed in sesar 2020 and the realisation of the digital european sky vision in sesar phase d the results are expected to contribute to capacity operational efficiency safety environment and cost efficiencythe sesar solutions with the trleocvm levels at the start and end of the project aresolution 4 improved automation in sector planning and separation management via enhanced trajectory predictions and controller tools including the completion of solution 53a from sesar 2020 to v3 initial trl4v2
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first time ultrasensitive and simultaneous quantification of proteins interactions and posttranslational modifications in single cells to enable exponential growth in proteomics and interactomics
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in a human cell there are about 20k protein coding genes genome that originate 100k proteins proteome proteins are involved in complex networks of proteinprotein interactions ppis influenced by posttranslational modifications ptms the interactome of living cells 800000 entities the genome is mostly static throughout cell lifetime and can be sequenced today in 1h the proteome and interactome are changing with eg environment and health and not yet fully known todays methods for proteomics and interactomics are tedious and lack sensitivity quantitativity and parallelismpicongs combines ultrahigh sensitivity 10 fm with high parallelism measuring proteins ppis and ptms simultaneously 50 targets this will disrupt the global proteomics market 29 b worth 16 cagr this will fertilise groundbreaking academic research and accelerate developments in eg pharma drug discovery biotech biomarkersdiagnosis and agrotech crop sciences industries
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museum artwork sustainable technology for energy efficiency and conservation enhancement
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the masterpiece project aims to create a transformative change in the conservation of wooden panel paintings wpps from the middle ages and renaissance integral to our shared cultural heritage these artworks are susceptible to environmental conditions like humidity and temperature fluctuations challenging traditional conservation methods the project proposes an innovative approach by integrating energyefficient climate control and advanced digital modeling to optimize both preservation and sustainabilitytraditional climate control systems in museums contribute to an unsustainable energy footprint masterpiece addresses this by using adaptive climate control strategies that take into account the unique needs of each artwork through collaboration with the getty conservation institute gci a leader in art conservation the project will develop digital twinsdigital replicas that simulate the artworks hygromechanical behavior in realtimerather than focusing solely on vulnerability masterpiece introduces the concept of resilience through fragilityresilience curves these curves enable a nuanced understanding of how artworks respond to environmental stressors informing targeted and effective conservation strategies that harmonize with energy efficiency goalsthe project will unfold in two key phases the first phase at the gci will focus on creating the digital twins and fragilityresilience curves the second phase will conduct mechanical characterization tests on historical paintings to validate and refine these models ensuring their broader applicability and impactmasterpiece aims to redefine standards in art conservation by offering an interdisciplinary solution that harmonizes the need for energyefficient practices with effective longterm preservation by integrating advanced technologies with conservation science masterpiece aspires to make a lasting positive impact on global art preservation strategies
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unlocking efficient biobased fertilisers for soil sustainability from underutilised side streams
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landfeed will focus on creating value from underutilised waste from the agrofood industry forestry urban and natural waste implementing circular and local solutions that allow waste to be valorised by placing it in a circular framework and producing innovative biofertilisers to improve europes selfsufficiency in addition to optimising and implementing innovative nutrient recovery technologies work will be carried out on a new generation of coatings for these biobased fertilisers capable of improving their efficiency through controlled nutrient release mechanisms in this way landfeed will contribute to a better management of the fertiliser provided we will contribute to lower greenhouse gas emissions and a reduced impact on the environments water resources landfeed will ensure that the solutions and results of the project are locally driven through the different use cases the use cases will consider all links in the value chain that will participate as lighthouses serving as demonstrators and disseminators of the technologies results and applications developed during the projectthese use cases will also contribute to the objectives of the soil strategy by enabling the restoration of soil health through the enhancement of its specific and functional biodiversity at the global level the business model will be defined in its entirety with the aim of maximising the replicability of these use cases and facilitating their implementation in other european areas and regions
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transforming industrial part replacement and after sales through visual search and synthetic images
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industrial manufacturers and their customers need to identify and retrieve spare parts quickly and efficiently our visual search engine allows any spare part to be found in manufacturers catalogues by simply taking or sharing an image of it it has proven to be by far the most accurate tool compared with several large competitors most importantly we can overcome the key hurdle to visual searches for industrial applications the availability of images for ai network training large manufacturers struggle to undertake the timeconsuming and expensive effort of producing these images for all spare parts and machines through manual photography we are the only company in the market who can produce synthetic images from cad data which outperform real data in training and search accuracy moreover we can onboard customers in a matter of minutes at nyris we give search the power of sight
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european network for neurodevelopmental rasopathies
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cardiofaciocutaneous syndrome costello syndrome and syngap1related encephalopathy are rare neurodevelopmental rasopathies manifesting with severe intellectual disability seizures and autism spectrum disorder these symptoms are underdiagnosed and lack approved therapeutic options euras aims to develop new effective therapies and operative disease management for rasopathies with strong support of patient organizations from 13 countries a new patient reportbased registry for stratification of patient cohorts and evaluation of treatments will be implemented to clarify the pathophysiology of rasopathies and to identify cellularmolecular disease signatures as biomarkers for drug screening and for therapy validation euras will generate new and employ existing disease models phenotypical screenings of drug libraries assisted by automated highresolution highcontent pipelines will be conducted on differentiated electrically active patient ipscderived neurons preclinical proofofconcept trials with repurposed drugs antisense oligonucleotides and motorcognitive training will be performed to achieve reversal of seizures and autistic behavioural traits in animal models to provide patients with less invasive treatments new technologies for efficient drug delivery of treatments to the brain will be developed and validated finally euras establishes europewide patient association to improve awareness and exchange between affected families and to foster their access to knowledge and therapies with all these measures euras delivers new effective therapies and set the frame for early and accurate diagnosis of neurological symptoms in rasopathies which are not available at present moreover some results of euras will be widely transferable fostering development of therapies even for unrelated diseases thus euras will sustainably improve the lives of affected people and strengthen expertise of health systems in europe and worldwide
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change hubs for ecosystemic social solutions
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it is now widely accepted in europe that we need new approaches if we are to tackle the systemic and urgent societal challenges we face traditional technological or business innovation alone is not sufficient social must be part of the bigger innovation picture with significant support from the european commission social innovation is currently well embedded in several policy agendas and funding streams there are hundreds of social innovation centres university research teams accelerators and educational courses labs accelerators and incubators of all kinds as well as a great number of toolkits presenting the various innovative approaches and methodologies that can be applied by students and established practitioners alike despite this success the full potential of social innovation remains untapped different project reports and academic papers published in the past five years have pointed to several interconnected barriers hindering social innovation initiatives drawing specif despite this success the full potential of social innovation remains untapped different project reports and academic papers published in the past five years have pointed to several interconnected barriers hindering social innovation initiatives drawing specifically on the outcomes of three projects that members of this consortium have participated in sidrive sic and labs for social innovation we highlight the following challenges that merit critical attention1 social innovation lacks access to finance scaling models and qualified personnel and is not applied enough2 social innovators act in silos and are not integrated into the wider innovation ecosystems 3 social innovation toolkits are plentiful but there is a lack of records about the tools effectiveness and pertinence the chess project tackles the above challenges headon by designing implementing and testing a social innovation action manual in four locally specific contexts
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correction of syngap haplodeficiencyrelated defects in ampa receptor dynamic nanoscale organization
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pathogenic syngap gene mutations generally lead to haploinsufficiency and account for up to 1 of intellectual disability cases syngap is one of the most abundant postsynaptic proteins that maintains a low basal activity in excitatory synapses it acts through ampa type glutamate receptors ampar that mediate most fast excitatory neurotransmission in the brain in syngap haplodeficiency ampar trafficking and surface expression are dysregulated and synaptic plasticity is impaired in our project we aim to 1 study how syngap regulates the surface nanoorganization of ampar subunits 2 validate a novel strategy to stabilize syngap in the postsynaptic region using innovative molecular tools 3 exploit our strategy as well as pharmacological approaches to restore normal synaptic transmission and plasticity in syngap neuronswe will use recently developed and validated antibody fragments against each ampar subunit with 4color dstormupaint microscopy to uncover their specific nanoscale coorganization furthermore we will test novel synthetic nanobodies specific to calcium permeable receptors to provide the first direct microscopy evidence on their synaptic distribution in relation to syngap haplodeficiency we will test a newly engineered family of proteins created in our group that aims to stabilize the complex of psd95 and syngap to counter the loss of half the syngap protein in haplodeficient neurons at different time windows as syngap affects neuronal maturation and synaptic development we will also aim to reverse the upregulation of calcium permeable ampars observed in syngap haploinsufficiency by selectively blocking them with naspm together our expected results will provide unprecedented insight to the regulation of excitatory synapses as well as novel strategies to experimentally correct syngap haplodeficiency
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raising the biobased industrial feedstock capacity of marginal lands
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at the present 6070 of all soils in europe are in unhealthy conditions mainly because of poor land management practices pollution of soils intensive agriculture and the constant effects of climate change this situation is further aggravated given that 25 of land is at a high or very high risk of suffering desertification in most parts of europemarginup proposes a strategy to secure use and return profitability on marginal lands its main objective is to introduce climateresilient and biodiversityfriendly nonfood crops for sustainable industrial feedstock in marginalised and lowproductivity lands the project will focus on producing biomass to be used as raw material for the production of bioproducts and biofuels which in turn will create a sustainable and circular value chain increasing the farming system resilience in rural areas to further enhance the biodiversity beneficial impact marginup is focusing on understanding which marginal lands are suitable for low iluc biomass productionthe knowledge gathered in this project will be put into practice in 5 different use cases located in 5 different regions across europe mediterranean lands spainmine lands greeceboreal lands swedenwetlands germanycentral europe hungarymoreover international cooperation has been considered and examination and identification of marginal lands will extend to noneuropean countries such as argentina and south africato ensure the success of the project marginup will have a replication network to address the needs and requirements of relevant stakeholders including policymakers land managers farmers the biobased industry environmental authorities the academia and the civil societymarginup is directly contributing to european policies such as the european green deal the circular economy action plan and the bioeconomy and biodiversity strategies
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safe and sustainable by design microbial and ligninbased biosurfactants sourced from sustainable feedstock for home personal care and agrochemical application
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today only 4 of the surfactant market share consists out of compounds that are 100 based on biomass fully biobased surfactants or biosurfactants while there is an urgent need for nonhazardous safe and sustainable by design ssbd biosurfactants bss the biosurfactant market is expected to grow at a cagr of between 52 and 105 between 2022 and 2028 however the diversity of the currently available safe and sustainable biosurfactants is not at all sufficient to meet the market needs diversity is key the surfs up project aims to bridge this gap by demonstrating optimized and costefficient processes for 9 second generation 2g ssbd biosurfactant products that will be formulated in prototypes in home and personal care and agrochemical applications the 2g feedstocks will include wood processing waste sugars and lignin and regional foodindustrial processing waste the 9 surfs up ingredients are 1 7 microbial biosurfactants ie 2 dropin sophorolipids 2 newtomarket sophorolipid type biosurfactants 1 newtomarket mannosylerythritol lipid and 2 newtomarket lipopeptides and 2 2 newtomarket chemically produced bss from lignin of wood processing waste these ingredients will be fully characterized physicochemical properties and evaluated according to the ssbd framework criteria and ecotoxicity testing the production of ssbd bss will be scaled up ao in the surfs up demo plant that will be built and used to demonstrate prototype formulations in the aforementioned applications particular attention will be given to costefficient and sustainable productionuse of the ssbd surfs up biosurfactants evaluated within full teas and lcas finally surfs up will operationalize the ec ssbd framework for the development of novel bss and will work on all aspects considering social awareness and acceptance of these products via the organisation of consumer surveys engaging stakeholders policy makers and social media tools
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from generalised hydrodynamics to new effective descriptions of nonequilibrium quantum systems
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understanding the outofequilibrium dynamics of manybody quantum systems is one of the main challenges of the physics of the 21st century despite the complexity of the field significant steps forward have been achieved thanks to the parallel development of advanced theoretical tools numerical methods and experimental verifications made with ultracold atoms and ions in this context generalised hydrodynamics ghd represented a fundamental breakthrough which permitted the use of new integrabilitybased techniques to include previously untreatable experimental effects such as spatial inhomogeneities and temperature gradients but from this milestone new questions inevitably arise for which the proposed action stands as a targeted plan of investigation on the one hand a known weakness of any hydrodynamic approach is the loss of longrange quantum fluctuations although a few attempts to include quantum effects in the formulation of ghd are present a definitive answer to this problem is still far on the other hand the advent of ghd indirectly revived the interest in diffusive models with the ultimate goal of developing a quantum analogue of the celebrated macroscopic fluctuations theory in detail by combining analytical and numerical methods the proposal aims the fulfilment of three objectives within this landscape consisting of research and training activities dedicated to i investigating the quantum corrections of ghd and clarifying the connections among the available theories aiming at a single description of quantum ballistic transport ii exploit the developments in quantum ballistic transport to describe currently feasible measures of the correlations of quantum gases outofequilibrium iii connect ballistic to diffusive quantum transport starting from simple settings altogether these packages represent a fundamental step in the understanding of the emergent hydrodynamic descriptions of nonequilibrium quantum systems
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forecasting and preventing human errors
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human errors remain the main source of incidents they can lead to fatalities traffic accidents or product defects and cause high economic and social cost while some errors can still be corrected if they are detected in time many human errors cause high costs as soon as they occur or are even irreversible in these cases it is very important to recognize human errors before they occur the goal of this project is therefore to develop methods based on artificial intelligence that forecast human errors from video data we focus on erroneous and unintentional human actions and we aim to support humans to avoid them in order to achieve this goal we aim to solve three tasks jointly we aim to develop methods that forecast human motion and intention with a very low latency such that unintentional actions can be recognized before they occur without the capability to interfere however even the best forecasting model does not prevent human errors we therefore aim to develop a model that generates an auditory feedback if an error is forecast the feedback however should not only warn humans but also guide them such that they can successfully complete their intended action finally we aim to model how humans will react to the feedback we thus aim to develop a model that forecasts the motion of humans and objects they interact with that recognizes human errors before they occur and that guides the human motion via auditory feedback in order to prevent errors the model should automatically decide if and what auditory feedback is generated by reasoning how the feedback will affect the motion of persons that are closeby while we aim to showcase that the developed technology is able to prevent errors before they occur this technology has the potential to drastically reduce the social and economic costs caused by human errors in the long term
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source and mobility of mercury within a continental magmatic system
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mercury hg is a volatile element that is used for industrial and technological applications and can be potentially toxic for any ecosystem in earth science its accumulation in sedimentary sequences has been recently used to link the major phanerozoic climatic and biological crisis to massive volcanic events this is because volcanic degassing is the main mechanism that releases hg to the atmosphere while these aspects are receiving increasing scientific interest it is still unclear what is the source from which a volcanic system acquires its hg content prior to magma degassing the few studies addressing the behaviour of hg in the deep earth appear to have adopted sample preparation and analytical procedures that might have unintentionally under or overestimated the actual hg contents in the rock samples project stecalmy seeks to understand the source and mobility of hg in the earths crust by studying the sesia magmatic system sms western southern alps italy an exposed continental magmatic system that can be tracked from its deepest roots up to its volcanic products through a rigorous sample preparation procedure and by testing different analytical methods i will firstly develop a methodological and analytical protocol that optimises the analyses of hg in crystalline rocks such protocol will then be used to investigate the hg content in carefully selected rocks from the sms from the uncontaminated and undegassed magmatic rocks to the metamorphic rocks of the crust in which they emplaced and the volcanics erupted to the surface this will be combined with petrography and major and trace element geochemistry of the same samples in order to quantify the gain or loss of hg in magmas during assimilation crystallisation and degassing in a continental setting project stecalmy will produce the first methodologicallyrobust model on the source and mobility of hg within a continental magmatic system
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when next generation multiple access ngma meets reconfigurable intelligent surface ris in 6g wireless networks
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recently 5g wireless systems are currently reaching commercial maturity the increasing carrier frequency decreases the coverage area of base stations the massive number of devices also increases the burden of civil communications in this fellowship the integration of next generation multiple access ngma and reconfigurable intelligent surface ris are investigated for the sixthgeneration wireless networks 6g which facilitates the development of both academic and industry in europe three objectives aim to propose new ngmaris frameworks and develop novel passive beamforming strategies where both the data rate and the number of accessed users of civil communications can be improved by 50 while only 20 extra energy is needed therefore more people can enjoy better and cheaper wireless communication services and europe can also reduce the demand for fossil fuels as expected by 3gpp the performance gain offered by the ngmaris framework can provide extra communication services for both civil communications and iot services which is capable of satisfying the requirements of europe in the next 1020 yearsin order to achieve the ambitious objectives work plan1 wp1 and wp2 deal with ngma and rissimultaneously transmitting and reflecting starris transmission which can improve the coverage area of bss and the data rate of users wp3 links ngma ris satellite communications and satellite navigations as a full picture of the future applications and it can provide cheaper satellite communication services based on existing satellites more specifically wp3 requires only 30 satellites to achieve the same goal compared to starlink which requires more than 12000 satellites three wps in this fellowship have farreaching academic impacts economic impacts and society impacts where the estimated market is expected higher than 10 billion euros
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the elusive role of physicality in virtual trials towards a new understanding of legal participation
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video links are widely used in courtrooms across the globe but there is a mounting apprehension that the legitimacy and fairness of trials are threatened by the diminishment of physical interactions this format entails the problem addressed in virtutrials is that current concerns regarding the threat video links pose to trials by diminishing physical interaction may not be substantiated by contemporary examination instead these concerns may originate from a fetishization of physicality despite physicality remaining an enigma given the centrality and importance of trials in democratic societies this has important implications for legal security and the continued trust in the legal system it is especially critical considering the impending shift to virtual reality trials devoid of physical presencevirtutrials will identify how physicality and the absence thereof shapes contemporary trials and participation within in order to show if and how trials can retain their legitimacy and fairness in virtual settings the stateoftheart pinpoints three interlinked themes regarding physicality which inspire the research questionsrq1 how does participation format shape participants accomplishment and experiencerq2 what are the social ingredients of virtual justice ritualsrq3 how are displays of credibility and remorse understood and evaluated in physical versus virtual trialsvirtutrials has an innovative abductive and interconnected design using a multimethods approach including ethnography qualitative interviews and a combined qualitative and quantitative analysis of written judgements by uniquely drawing on a social scientific perspective with interactionist theory it aims to analyse and challenge the current understanding of trials as facetoface interactions in todays rapidly digitalising world where interactions in virtual settings are progressively prevalent and intricate virtutrials contributes vital knowledge on virtual interactions
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yearround firesafe and sustainable solar management materials
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at present temperature regulation of spaces and buildings is responsible for 31 of the global final energy consumption and 30 of the entire worldwide co2 emissions although solar thermal conversion high solar absorption and passive radiation cooling high solar reflection have presented huge potential for the energyfree temperature regulation the opposite mechanisms limit their application in one object failing to respond to the changing climates yearround besides applied onto the surface of plenty of spaces and buildings high fire safety and sustainable processability are vitally important yet urgent to be addressed therefore facing these challenges the overarching aim of this ambitious yet achievable project solarmater is to develop yearround firesafe and sustainable solar management materials via the spontaneous and energyfree switch of solar thermal conversion and passive radiation cooling based on a breakthrough approach which is a creative integration of thermochromic microcapsules tcms synthesis of biomass flameretardant chain extenders and solventfree polymer coating technology in details based on microencapsulation technology and structure design tcms designed will optimise the solar reflectivity solar absorptivity and ir emissivity by introducing bo and sio bonds with high ir emissivity to highrefractive tio2based shell materials fully biomass flameretardant chain extenders and inorganic shell materials will enhance the fire safety with the condensed flame retardancy mechanism meanwhile solventfree polymer coating will impart desirable processability and further enhance the sustainability solarmater is a typical multidisciplinary and requires complementary expertise from the host polymer chemistry fire retardant materials and the researcher solar energy radiation cooling contributing to achieving the sustainable development goals and european green deal of eu policies
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realistic water budgeting in protected agriculture
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protected agriculture makes use of technology to create an optimal environment for crops growth in particular protected agriculture makes use of covers to shield crops from adverse meteorological events including storms droughts temperature extremes and strong winds however these controls inherently disrupt the water budget terms currently accounted for in hydrological modelling runoff evapotranspiration soil moisture storage infiltration etc for the first time the project realistic water budgeting in protected agriculture rewatering will deliver and validate a methodology for catchmentscale models ie cathy to explicitly account for the role of protected agriculture on water quantity and quality rewatering will also unprecedently monitor water quality in a stream draining a small catchment mainly used for protected agriculture by means of highresolution mass spectrometry i will carry out rewatering in a globally recognised research group for hydrological modelling overall the host university will be the perfect interdisciplinary hub to accomplish the proposed research because it will provide internal collaborations with excellent academics in hydrology agriculture and environmental chemistry protected agriculture is a growing reality worldwide currently covering 15 of the agricultural lands and often occupying entire hydrological catchments the socially relevant and scientifically innovative interdisciplinary activities proposed in this research are urged to expand catchmentscale hydrological models to predict short and longterm water quantity and quality resulting from water management characteristic of protected agriculture
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water4all water security for the planet
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water is central to all human activities to all components of the eu green deal and to several un sdgs the water4all partnership aims at enabling water security for all on the long term through boosting systemic transformations and changes across the entire research water innovation pipeline fostering the matchmaking between problem owners and solution providers it gathers more than 70 partners ri funders environment ministries local authorities european national and regionalscale networks research performing organisations it will collaborate with other relevant ri initiativeswater4all proposes a portfolio of multinational crosssectoral activities targeting a variety of actors intending to generate the following outputs strengthen the water ri collaboration at european and international levels across at least 31 countries notably through joint transnational calls coordinate and leverage the activities of the water ri community support and promote the demonstration and access to market of innovative solutions produce share and better communicate waterrelated knowledge data from local to global scales enhance talent development of water ri professionals foster capacity development and lifelong training of water policymakers stakeholders and civil society design implement approaches for participatory development of innovationwater4all will run its activities across 7 themes of its strategic agenda water for circular economy water for ecosystems and biodiversity sustainable water management water and health water infrastructure international cooperation water governancewater4alls outputs will contribute to deliver sound knowledge tools and evidence basis on water for policy decisionmaking improve consideration of water impacts in all relevant policies enhance the fieldmarket use of innovative solutions to water challenges increase citizens awareness and engagement for an inclusive water
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allinone surface methodology for corrosion protection in metal additive manufacturing
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metal additive manufacturing mam also known as 3d metal printing has attracted a great deal of attention from scientists and industries due to its potential in the stateoftheart production of complexshaped designs in the transport industry mam is considered the fundamental technology for industry 40 since it is a lowcost and energyefficient processing method for metallic components with a minimal environmental impact nevertheless the surface finishing of mam components is uncontrolled during the fabrication resulting in low corrosionresistant components so far current postsurface treatments are nonecofriendly nonenergy efficient and the achieved corrosion resistance does not fulfil the service life requirements in this scenario the main goal of the sumam project is to achieve the full exploitation of mam in the transport industry following the european green deal namely as a major innovation we will develop an innovative allinone methodology to achieve the highest corrosion resistance during printing removing the need for posttreatment we will combine two approaches surface creating by i insitu laser processing and ii incorporation of additives during printing to control the surface without affecting the bulk properties of the final components our target materials are four aluminium alloys and one stainless steel widely used materials in the transport industrythis project is an outstanding opportunity for the fundamental advancement of mam science by a technological and economically feasible methodology the sumam project presents the best research scenario for dr rubn del olmo martnez candidate to further develop his scientific career the sumam project is led by prof dr ir iris de graeve and prof dr ir herman terryn from the surf research group of the vrije universiteit brussel vub with a proven outstanding track record in both academic and industrial sectors in the scope of the proposal
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modelaware learning for imaging inverse problems in fluorescence microscopy
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this project will develop modelaware ie physicsinformed learning methods for solving imaging inverse problems iips in fluorescence microscopy imaging fmi iips are frequently encountered in fmi whenever a visual representation of a biological sample needs to be reconstructed from incomplete and noisy input measurements such iips are typically illposed their solution if it exists is unstable to perturbations classical modelbased approaches reformulate the iip at hand as an energy minimisation task such approaches rely both on the approximate knowledge of the complex physical processes involved and on the mathematical design of handcrafted optimisation methods whose tuning is often very timeconsuming concurrently the impressive development of machine and deep learning methods has enabled the applied imaging community with new datadriven methodologies providing unprecedented results in tasks such as image classification the performance of datadriven methods for solving iips in fmi however is halted by their intrinsic unstable behaviour in malin i propose an integrative paradigm where the stable performance of modelbased approaches is combined with the effectiveness of datadriven techniques by means of shallow modelconstrained learning and deep physicsinformed generative approaches the reliability of the modelaware methods proposed will be justified by theoretical results providing reconstruction and convergence guarantees the study will further account for possible geometric invariances and imperfect physical modelling showing robustness to modelling errors which are frequent when standard lowcost equipment is used algorithmic acceleration strategies and inexactstochastic algorithms will be devised to guarantee efficient performance also under limited computational resources and training data the methodologies will be deployed on several iips in fmi and democratised through the release of open software and plugins
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molecular mechanisms of thyroid hormone synthesis from atoms to organoids
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metabolic functions in vertebrates are ruled by thyroid hormones produced by the thyroid gland and secreted into the bloodstream thyroid hormone levels modulate growth development and many other key processes across the lifespan and their impairment severely affects human health despite extensive studies controlling hormone levels in vivo remains a major challenge synthesis of thyroid hormones occurs extracellularly via iodination of thyroglobulin they must then undergo endocytosis before they can be released into the bloodstream yet most thyroglobulin forms a colloid matrix within the gland enabling iodine and hormone storage for the body how these three mechanisms are balanced to provide physiological levels of hormones to the organism remains an outstanding question using an integrative structural biology approach the proposed research will focus on unravelling the molecular mechanisms underlying the major checkpoints of thyroid hormone synthesis my research group will combine electron cryomicroscopy with biochemical and light microscopy tools to study thyroid hormone regulation at different scales from in vitro reconstituted systems to native thyroid organoids first we will elucidate how thyroglobulin iodination modulates hormone yields and modifies thyroglobulin structure second we will determine the mechanism of thyroglobulin endocytosis regulated by two main receptors third we will decipher the mechanism of storage and depletion of the thyroglobulin storage matrix these approaches will allow us to reproduce the complexity of thyroid hormone synthesis at high resolution and in a native environment my expertise in structural biology and my pioneering work on thyroglobulin puts me in an ideal position to carry out this work the expected outcome and method development of this research will open a new front in thyroid structural biology and inspire alternative strategies for the control of thyroid hormone synthesis in vivo
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sustainable plasmonic membranes for water remediation
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plasmon chemistry is an emerging field in which light energy is converted into chemical energy or heat in metal nanoparticles nps previously we have investigated the degradation of small organic molecules such as brominated nucleobases and halogenated thiophenols through excitation of nps by visible or even nearinfrared light these results inspired us to apply plasmonic nanomaterials to decompose organic micropollutants such as pharmaceuticals in waste water many pharmaceuticals are categorized as water pollutants of emerging concern due to their harmful effect even in trace quantities as they may cause damage in different living organisms present in and around aquatic systems many studies have noticed that such micropollutants show a ubiquitous environmental presence owing to their high water solubility and due to inefficient wastewater treatment to avoid severe environmental human health and biodiversity problems novel solutions for water remediation need to be developed within the susplasmem project a sustainable plasmonic membrane based on nanocellulose and plasmonic nanoparticles will be used for an efficient degradation of micropollutants by visible light the degradation by visible light is very costeffective and allows for the use of sunlight the material is easy to be scaled up and the scope of molecules to be decomposed will be studied by considering representatives of antibiotics other smallmolecule pharmaceutics and polyfluorinated alkyl substances the susplasmem project will focus on validating the effectiveness of the generated membranes with respect to micropollutant removal from wastewater samples strategies will be developed to enable water remediation in flow and a demonstrator model will be constructed finally we will work in close collaboration with industry partners to establish the implementation of the technology within an industrially relevant environment
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toroidal propellers for efficient and sustainable aviation
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the torpropel aims to advance aircraft propulsion technology by developing and upscaling propellers of toroidal geometry which are distinguished for their thrust efficiency and noise reduction utilising advanced carbon composites and stateoftheart robotic manufacturing processes this technology has the potential to significantly improve the performance of propellerdriven aircraft a distinct category of aviation platforms ranging from smaller piston driven or electric aircraft to vertical takeoff and landing aircraft vtols unmanned aerial vehicles uavs and even aircraft based on novel designs concepts such as those featuring distributed propulsion systems torpropel sees the development of advanced aerospacegrade carbon composites alongside the implementation of innovative robotic manufacturing solutions to ensure the achievement of critical performance objectives and a lightweight profile while also prioritising the propellers recyclability and repairability moreover the project incorporates sophisticated condition monitoring systems directly into the propeller structure essential for the realtime assessment of propeller structural health thus ensuring safety and considerably reducing the time and costs associated with maintenance overall the torpropel technology is expected to offer significant improvements in propeller performance durability weight sustainability and recyclability the proposed technology is thus expected to have a significant contribution to the scientific field of aircraft propulsion technologies improving upon the operational effectiveness and environmental sustainability of aviation and also by paving the way for a new era of shortdistance air travel that is both quieter and environmentally friendly
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janus graphene supported single atom catalysts for ultrasensitive cytokine point of care sensors
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cytokines such as tnf hold immense significance as protein biomarkers pivotal for diagnostic prognostic and therapeutic management across various clinical disorders like alzheimers disease sepsis and cancer nonetheless prevailing techniques like enzymelinked immunosorbent assay elisa and polymerase chain reaction pcr prove to be expensive timeintensive and reliant on specialized personnel intricate instrumentation and infrastructure furthermore the performance of present biosensing techniques necessitates refinements in terms of realtime outcomes sensitivity affordability and userfriendliness within this context the response project sets out to forge an innovative approach intertwining janus graphene derivatives jgds and single atom catalysts sacs or atozymes for pointofcare poc biosensors for cytokine detection this undertaking involves the strategic utilization of selectively and densely functionalized jgds serving dual roles i as signal transducer immobilized on a paper lateral flow electrochemical sensor lfes and carrying the cytokine bioreceptor primarycapture antibody ab1 and ii as signal amplifier jgds housing the sacs and the secondarysignal antibody ab2 which binds to a different epitope of cytokine the binding between tnf and jgdsab1 initiates the sandwich formation with sacjgdsab2 complex at the test region here the sacs catalyze the oxidation of an appropriate reporter molecule liberating electrons and thereby significantly amplifying the signal output which can be quantified through an integrated electrode system repsonse offers affordability point of care readiness and commercialization potential importantly responses strategy defines the blueprint for transitioning from the current symptomfocused and latestage diagnosis to the nextgeneration prognostic biomarkerguided preventative or therapeutic treatment management and improve lifequality of millions of people worldwide
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neurowelfare in cash transfers measures cts do welfare cash transfers show different brain activity and improve equality
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neurowelfare in cash transfers measures cts do welfare cash transfers show different brain activity and improve equality nw aims to pave the way for the interdisciplinary study of the brain functioning and the sociocognitive impact on self and social perception in the experience of the two main paradigmatic cash transfer schemes conditioned cts ccts and unconditioned cts ucts nws idea is born from my phd effort in which i studied a basic income pilot project observing a mindset shift in the redistributive beliefs and attitudes of community financiers showing me the need for a neurophysiological understanding of cts phenomena nws achievability has been improved from the previous projects application in its methodological operationalization better defining the outcomes measurability and scalability to isolate effects of cts on the brain the assessment of social protection measures is usually done by looking at the behaviors of the welfare recipients in addition social neuroscience efforts are frequently focused on mental manifestations observed in the laboratory environments what if the modern techniques to investigate brain activity would be applied to healthy individuals perceiving income support in their social environment by utilizing an interdisciplinary and multidimensional approach i pursue to combine the knowledge and the methodology of human sciences with those of social neurosciences to detect and measure the effect of cts on brain from three empirical intertwined perspectives 1 neurophysiological 2 cognitive and 3 interactional ill train my interdisciplinary skills thanks to experienced supervisors in vilnius university university of oregon and isctelisboa nw tackles the complexity of redistribution social phenomena advancing my career progress in the brandnew field of neurosociology
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wila1991 womens intellectual and artistic labor 19191991
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wila1991 main aim is to to bridge the gap between intellectual history and labor history and through this methodological innovation not only highlight the disparity between intellectual labor and intellectual achievements but also challenge historiographys perception of the latter while intellectual history predominantly focuses on artistic and intellectual achievements it often fails to question the underlying conditions that made such achievements possible consequently many marginalized groups have been excluded from the canon as they did not have the necessary working conditions to consistently produce intellectual or artistic labor the wila1991 project focuses specifically on womens intellectual labor from 1919 to 1991 utilizing yugoslavia as a transnational laboratory space to observe the dynamics of intellectual and artistic labor across different time periods generations social classes nationalities and ethnicities the projects outcomes will contribute to establishing new norms for reevaluating artistic and intellectual achievements ultimately broadening and decolonizing the canon the project examines work conditions considering the power structures associated with intellectual authorities social prejudices intimate beliefs and invisible social agreements at various times to achieve this it explores the intersection of intellectual labor and gender history by drawing on a diverse range of sources in different languages slovene croatian serbian german and amplifying the voices of women from ethnic and sexual minorities this project will investigate working conditions attitudes towards work legislative changes family dynamics public reception financial compensation and care work in order to understand the division between intellectual work as labor and being an intellectual as a status
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characterizing and harnessing tumorreactive t cells in the brain
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personalized tumor immunotherapy vaccines and t cell therapies requires the selection of few immunogenic epitopes recognized by tumorreactive t cell receptors tcrs from thousands of potential tumor antigens in each tumor this selection is a huge challenge particularly in brain tumors where access to tumor tissue is limited and tumorinfiltrating t cells tils are sparse centricbrain will reverse this epitopecentric approach by directly harnessing tumorreactive orphan tcrs from tils for personalized brain tumor immunotherapy using human brain tumor tissue we have developed and experimentally validated predictcr a novel approach using machine learning and explainable ai to derive a classifier that predicts tumorreactivity of such orphan tcrs based on the expression of signature genes with 90 accuracy across multiple tumour entities centricbrain will employ predictcr to develop a personalized adoptive cell therapy using transgenic t cells with tumorspecific tcrs and improved function centricbrain hypothesizes that the signature genes underlying predictcr determine the phenotypic and functional properties of tumorreactive t cells and that predicted tumorreactive orphan tcrs can be employed for adoptive therapy with personalized tcrtransgenic t cellsaim 1 will refine predictcr by characterizing the transcriptional programs and spatial distribution of tumorreactive t cells in human brain tumor samples aim 2 will define the functional relevance of transcriptional programs for tumorreactive t cells in syngeneic humanized and patientderived xenograft brain tumor models aim 3 will validate the predicted tumorreactive orphan tcrs by adoptive transfer of t cells genetically engineered to express predicted tumorreactive tcrs centricbrain will thus revolutionize precise and efficient implementation of personalized adoptive cell therapy for brain tumors using t cells expressing tumorreactive patientderived orphan tcrs
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boosting research for a smart and carbon neutral built environment with digital twins
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the overall objective of the project boosting research for a smart and carbon neutral built environment with digital twins smartwins is to build the capacities for the kaunas university of technology in lithuania through its sustainable energy in the built environment research group seberg within the faculty of civil engineering and architecture to conduct highquality research on the topic of next generation digital twins applied for allowing the transition to a smart sustainable resilient and carbon neutral built environment the concept of the smartwins project is to form a network between ktu and leading institutions in the field of energy and sustainability assessment of buildings with the use of industry 40 practices related research and innovation management for knowhow transfer and development of a longterm research collaboration ktu will twin with the politecnico di milano university polimi italy the centre for research and technology hellas certh greece a spinoff of the technical university of berlin contecht gmbh con germany and innotrope france aiming to develope its excellence and international reputation in the field to both cover fundamental research aspects as well as to further develop its skills practices and structures to conduct topnotch researchsmartwins includes activities in the field of research capacity building research management upgrade networking with the industry and the market as well as training smartwins consortium will also attempt to sustain the activities of the project by achieving further funding through succeeder projects in the fields of technology transfer innovation and research and postgraduate networks smartwins aspires to support the uptake and establishment of ktus seberg as a research hub of scientific excellence in the baltic region and beyond on the research topics of digitized assessment of sustainable buildings
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understanding the physiological and pathological relevance of liquidliquid phase separation by synuclein family of proteins
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proteins are among the most essential molecules of life in recent times it has been discovered that proteins can undergo liquidliquid phase separation llps to form highly efficient droplet reservoirs for its functionality however these concentrated protein droplets can also lead to pathological protein aggregation and toxic amyloid fibril formation one such example is synuclein syn which can undergo llpsmediated amyloid aggregation associated with parkinsons disease pd pathogenesis the physiological and pathological relevance of syn llps remains elusive in the context of many biological factors such as familial mutations presence of other synucleins protein modifications and lipid membrane interaction all of these factors significantly modulate the aggregation of monomeric syn in solution in this proposal i aim to elucidate and quantify the effects of these mentioned in vivo relevant factors on the phase separation of syn in a high throughput htp and quantitative manner while my work was the first to show that syn can undergo llps the host laboratory has developed a microfluidics based htp method perfectly suited for protein llps related research during the course of this project i will get trained on this particular technique along with several other sophisticated instruments the outcome of this project will significantly help to elucidate the molecular origins of pd and provide important insights with respect to the onset time and progression of pd pathology which is currently poorly understood the knowledge obtained from this study will have crucial impact on the european society and the results might also be of interest to the pharmaceutical industries to effectively design new drugs against the progression of pd pathology in the long run
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the hardness of finding good algorithms
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this is a project in computational complexity the project aims to answer the following question how hard is it to find a good algorithm for a given computational problemthis question can be asked in several different settings depending on what one means by algorithm what is the computational model computational problem is it a decision problem a search problem a communication problem and by good do we want an algorithm that uses little time little memory few logical gates this question has a deep connection with the problem of proving lowerbounds and in almost every setting where the question has been answered either the answer was discovered while attempting to prove lowerbounds or obtaining the answer required the development of new lowerbound methods it is also known that several variants of the above question are equivalent to fundamental open questions in cryptography pseudorandomness and learning theory the goal of this project is to answer this question in various settings where the answer is unknown in circuit complexity communication complexity data structures and algebraic models of computation for each of these settings we will either provide explicit methods for finding efficient algorithms or show that the problem of finding such efficient algorithms is nphard
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flying companion for floating litter collection
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plastic pollution is considered one of the most challenging environmental risks globally and rivers have been identified as a dominant pathway for the accumulation of plastic in the oceans the flyflic flying companion for floating litter collection project addresses this global challenge by deploying a firstofitskind robotic platform composed of multiple unmanned aerial robots to effectively collect litter from rivers and canals thus preventing such litter from reaching our oceans chiara gabellieri will carry out the flyflic project under the supervision of prof antonio franchi at the university of twente ut the netherlands the project contributes to european strategic priorities horizon europe mission on healthy oceans seas coastal and inland waters and global strategic priorities united nations sustainable development goals compared to stateoftheart solutions which are boatlike robots or fixed trapping mechanisms a flying platform can target desired spots can easily discharge the collected litter is low cost and is not hindered by nonnavigable spots such as dams and low bridges the general vision of the flyflic project will be accomplished through four specific objectives a novel prototype composed of two physically connected aerial robots and a net to be dragged in the water to collect the litter will be assembled the dynamic model of the complex manipulation aerial system embedding the waterrelated disturbances will be computed and a modelbased control law designed accordingly all the components for autonomous functioning will be integrated especially the control law and stateoftheart algorithms for object recognition and trajectory generation finally a user interface will be created to let a human monitor the task execution and possibly select actions and the cooperative humanrobot discharge of the litter will be made possible through the design of an advanced physical interaction control algorithm
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exploration of unknown environments for digital twins
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in the explorer project we will develop methods for automatically capturing and labelling video data in open worlds the ultimate goal is the great facilitation of the creation and maintenance of digital twins digital twins are virtual 3d copies of complex scenes such as cities factories or construction sites not just a 3d reconstruction they should capture the scenes semantics ie the identity of each object and the scenes dynamics ie how objects move because digital twins have the potential to be extremely useful for monitoring large complex sites and planning the development of these sites their forecast market is huge they remain mostly a concept because of important limitations of the current technology our methods will guide autonomous systems such as robotic platforms and uavs through complex and unknown environments to capture visual data for creating and maintaining digital twins this is extremely challenging as these systems will encounter objects without any prior knowledge about them and will have to collect sufficient data about them to the best of our knowledge this active and automatic capture in complex real environments is a new problem it is however very important to solve it as this will relax the need for human expertise and time currently capturing such data is done manually only by researchers and requires strong understanding of what the learning algorithms require to tackle the complexity of this problem our approach is inspired by techniques from artificial intelligence applied to the exploration of extremely large trees this approach will allow us to bring the perception part and the planning part of the problem together under the same optimization framework to formalize it and solve it efficiently to evaluate our developments we will create a dataset of annotated video sequences from working sites which we will share with the community
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predicting the future how our brain predicts future events for successful navigation through our dynamic environment
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to successfully navigate our dynamic environment our brain needs to continuously update its representation of external information this poses a fundamental problem how does the brain cope with a stream of dynamic input it takes time to transmit and process information along the hierarchy of the visual system our capacity to interact with dynamic stimuli in a timely manner eg catch a ball suggests that our brain generates predictions of unfolding dynamics while predictive processing theories assume an internal representation of future external states empirical research typically employs neural measures that capture an indirect consequence of prediction the representational nature of predictions remains largely unexplored one approach for investigating neural representations is representational similarity analysis rsa which typically uses models of static stimulus features at different hierarchical levels of complexity eg color shape category concept to investigate how these features are represented in the brain i have recently developed a novel dynamic extension to rsa that uses temporally variable models to capture neural representations of dynamic stimuli a proofofconcept meg study unveiled predictive neural representations of naturalistic dynamic input these promising initial results open the door for addressing important outstanding questions on how our brain represents and predicts the dynamics of the world in this project i aim to answer these questions i will execute the project at the prestigious donders institute in the lab of floris de lange a leading expert in the field of predictive processing the proposed project is unique as it tackles the rich dynamics of predictive processing in terms of neural representations it will allow me to conduct creative original and important research which will propel my scientific career and strengthen my competitiveness as a scientist
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excelling deep tech through placebased innovation and connected ecosystems for womenled startups
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epicx aims to accelerate and unlock excellence by connecting regional innovation ecosystems across the eu building on strategic areas of regional strength and specialisation and addressing the innovation divide and underrepresentation of talents within the european union the project enlists a diverse and strong multiactor interregional ecosystem network that resonates in a paneuropean alliance of interconnected ecosystems comprising 16 ecosystem builders hailing from the16 moderate and innovator countries the basis of this network is set to widely expand to all regions and engage quadruple helix players in collaborative efforts of cocreation coimplementation and coassessment of pioneering acceleration programme which encompasses a fstp scheme to support deep tech womenled startups embedded within this comprehensive programme are crossfertilisation activities and an innovative mobility scheme aimed at the selected startups ecosystem builders and members of the network will have dedicated opportunities for collaboration and knowledge exchange through tailored actions with a wealth of experience the consortium comprising 13 entities will spearhead efforts to develop and disseminate materials that underpin a comprehensive communication dissemination and exploitation strategy aimed at amplifying the impact of the epicx this includes the production of a white paper containing policy recommendations and an articlepaper to highlight key insights built around the three pillars of deep tech womenled startups and smart specialisation strategies the project activities and synergies fostered by a multilayer glocal approach will create a favourable environment for localplaced innovation and sustainable and inclusive growth
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electrical modulation of elastic moduli
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how could a textile change its feel upon the push of a button while we are accustomed to visual displays and loudspeakers interactive tactile perception largely eludes our experience textiles that change their pliability and texture would allow for communication using our sense of touch potential applications abound from humanmachine interfaces for robotics to new forms of virtual realityto facilitate such a tuneable mechanical response materials are needed whose stiffness can be altered this project will use conjugated polymers to realise stimuliresponsive materials the developed materials will be spun into fibres and yarns which will be integrated into prototype textile devices that can undergo a reversible change in pliability and texture the explored materials science concepts will open up a new line of research in the blossoming field of organic electronics while the applicationoriented part of the project opens new horizons for the interdisciplinary field of wearable electronics
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unmanned airborne water observing system
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background highresolution monitoring of rivers is important because rivers are severely affected by climate change and frequencymagnitude of extreme events are changing fast advanced insitu monitoring technologies have to be combined with satellite earth observation eo to obtain accurate reliable and spatiotemporally resolved information for effective decision support risk assessment climate change adaptation investment analysis and operational forecastingsurveillanceproblem being addressed traditional hydrometric monitoring of rivers is insitu and stationbased insitu monitoring networks lack spatial resolution have been declining in many regions and data accessibility is increasingly restricted because of growing conflicts between countries over water resources allocation in order to solve this problem hydrometric monitoring using satellite earth observation has to be combined with droneborne hydrometric monitoring technology for validation deployment in remote and inaccessible regions and to enable reliable and accurate river discharge estimationour solution uawos develops a droneborne water observation system providing key hydrometric variables bathymetry velocimetry water surface elevation at high spatial resolutioncoverage and databased productsservices supporting management and decision making uawos integrates airborne data streams with copernicus water bodies and water level services for cross validation and to estimate river discharge from satellite eo dataimpact we expect that uawos hydrometric monitoring solutions will be factor 23 cheaper compared to traditional insitu surveying uawos technology will provide very high spatial resolution with accuracy on par with traditional insitu monitoring the technology will support smart governanceregulation in the context of the green deal and create new opportunities for european business both as a standalone solution and in combination with satellite eo
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central european platform for plasmaenabled surface engineering
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colosse connects czech and slovak research facilities in the area of plasmaenabled surface engineering at masaryk university comenius university and university of west bohemia the three research centres of colosse have been supported by erdf investment in several periods since 2010 they have been shaping and supporting their regional ecosystems over a decade creating networks of interactions that facilitate knowledge transfer and exploitation of surface engineering technologies they have also developed international connections which however have led only to isolated cases of involvement in international ri projectsthe goal of colosse is to increase the participation of czech and slovak plasmaenabled surface engineering ri centres in horizon europe and future eu framework programmes for ri thus we will achieve upstream synergy of erdf funding with the horizon europethe goal will be achieved through 4 specific objectives1 strengthen the connections of colosse centres to worldleading ri centres2build conditions that will enable internationalization of human resources3develop skillset that enables interdisciplinary and intersectoral collaboration and facilitates creativity4enable sustainability of the colosse partnership through synergic use erdf and hefp resourcesthe colosse project will significantly boost the impact of erdf investments into plasma technologies in the academic sector of czechia and slovakia with joint forces we will be able to capitalize on our scientific and technological synergies and increase the complexity and added value of our research outputs with colosse we will reach out beyond our established collaborative networks in the local regional and national ri ecosystems we believe that the talent creativity skills and technologies that we harbour in the colosse centres can be a significant aid to increasing competitiveness of european industry and academia
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thermal management for the hybrid electric regional aircraft
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the thema4hera project takes on the huge challenge of onboard thermal management that comes with the introduction of hybrid electric power and propulsion systems in regional and short and medium range aircraft this will be achieved through development design and testing at trl 5 of wide range of innovative technologies from air supply to air conditioning systems thermal management to cabin air distribution whereas todays thermal management systems need to handle a heat dissipation of about 3550kw tomorrows hybrid electric regional aircraft will have to handle heat dissipation in the range of 300 to 1000kw with a consortium composed out of all key aerospace players in the market of thermal management this project will address almost all currently known thermal management technologies multiple twoway interactions loops with tra01 will be established integration requirements and feedback constraints and validation results to allow for further aircraft architecture optimization iterations through the development of a full digital twin the project will be able to simulate and optimize component level requirements for any given aircraft architecture this architecture will be taken from the exact project adjusted and refined throughout the project to eventually reflect the final hybrid electric aircraft architecture the project will validate and demonstrate its results in a fullscale demonstration test facility at fraunhofer ibp with the further refined models that will be available by then the project will also be able to calculate the achievements towards the expected outcomes in particular the environmental footprint the communication dissemination and exploitation actions will make sure that all necessary stakeholders will also be supportive to the eis of the first hybrid electric regional aircraft relying on thema4hera thermal management technologies
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green atmospheric plasmagenerated monoatomic oxygen technology for contactless atomic scale cleaning of works of art moxy
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climate crisis and unsustainable development increasingly threaten europes tangible cultural heritage ch yet environmentally hazardous chemicals persist in ch conservation practice the sustainable development goals of the eus green deal vision call for change in ch conservation but cannot be implemented without effective and affordable green alternatives soiling and deposition of carbonbased contaminants cbc such as fine particulate pollution smoke and vandalism all increasingly present formidable challenges to conservators and are an emerging threat to ch because of the inherent vulnerability of ch surfaces created with unconventional materials and studio practices existing ch cleaning methods require toxic solvents physical contact and water which can damage many sensitive ch materials and conservators equipped with only conventional means now encounter fragile and untreatable ch where soiling cannot be removed at all moxy aims to redefine the paradigm in cleaning methodology towards an ecoconscious approach by creating a transformative green noncontact technology based on atomic oxygen ao to selectively remove cbcs from surfaces that are otherwise untreatable ao cleaning methodology is a selective nonmechanical and liquidfree cleaning action without health or environmental risks residues or waste by leveraging a sophisticated yet simple technology moxy will enable practitioners to achieve unprecedented results that are green safer and more effective to achieve its goals moxy will bring together expertise from plasma physics conservation science sustainability science and conservators to conduct a novel investigation of the physical and chemical aspects of ao generation and flux to develop a proofofconcept ao system test the viability of ao technology for diverse ch materials and roadmap ao innovation to propel ao technology to the bench practice in ch conservation and beyond with its full potential yet to be realized
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allinone supramolecular approach as an innovative antiinfectious strategy
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despite the large therapeutic arsenal available to fight bacterial infections the development of new antiinfectious strategies is a major public health concern pathogens have indeed developed a variety of multi drug resistance mechanisms to escape destruction to circuvment these problems a few promising alternatives have been proposed a first one focuses on the bacterial adhesion step to the host cells which involves multivalent interactions between the glycocalix and bacterial adhesins molecular constructs displaying clusters of carbohydrates have been shown to efficiently compete with these complex recognition processes thus having the potential to prevent this key step of the bacterial infection the recruitment of natural antibodies nabs present in the human bloodsteam against biological targets to stimulate their destruction by the immune system is another alternative to fight pathogens this approach is based on the utilization of bimodal molecules namely args antibody recruiting glycodendrimers which are composed of two recognition domains one for nabs and one for receptors expressed by the pathogen the potential of this recruiting strategy was demonstrated recently in the pis team in the context of cancers where nabs have been efficiently redirected against tumors erc cog lego and erc poc theralego for the first time patholego will take advantage of these two antiadhesive and recruitment strategies simultaneously to fight resistant strains of pseudomonas aeruginosa we aim at developing hybrid args that will block extracellular process that p aeruginosa uses to infect host cells on the one hand and that will redirect nabs against the bacteria to induce their immunemediated clearance on the other hand with this unprecedented approach we will be able to both prevent infection and kill the targeted resistant bacteria to optimize the antibacterial effect
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exploring timedependent memory effects in matter with viscoelastic snapthrough of strips
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memory is crucial in living organisms and computers but is also a hallmark of complex materials such as crumpled paper glasses or sheared foams memory manifests itself in a stunning variety and is central both in fundamental research and for applications ageing adaptive matter programmable matter a new picture based on novel theoretical concepts related to the pathways of transitions between metastable states recently appeared and lead to a flurry of activity but so far this work focused mostly on quasistatic memory effects where the duration of the input does not matter yet timedependent memory effects are encountered in many complex systems and their microscopic origin is often unclear i therefore propose to study timedependent memory and pathways in a model mechanical system explicitly tailored to exhibit timedependent memory while allowing direct observations and manipulations specifically i will use viscoelastic thin strips that can toggle via a snapthrough instability between two states as a basic building block to create systems with emergent timedependent memory this project provides the key to experimentally probe and reveal the mechanisms of timedependent memory in matter as well as to design and create systems with complex programmable pathways i divide my project in three work packageswp1 first i will study the snapping of viscoelastic strips that will constitute the basic elements of this model systemwp2 next i will assemble several of these strips to monitor the emergence of timedependent memory effects and study both theirglobal aspects and pathways of transitionswp3finally i will aim to control timedependent memory and design complex systems with predefined pathwaysleveraging the versatility and experimental accessibility of model mechanical in this project i propose to use instabilities in viscoelastic strips to explore understand and control the emergence of time dependent memory effects in matter
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nanoconfinement effects from capacitors to catalysis
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the societal transformation to renewable energy necessitates more efficient ways to store energy this can be achieved by direct energy storage in batteries or supercapacitors scs or by using electrocatalysis to convert energy eg to green hydrogen the efficiency of such processes can be enhanced by increasing the surface of the electrode increase of the surface can be achieved by introducing pores into the electrodes however in recent years the porosity has reached the nanometre scale at this scale the pores become so small that the interfacial layer known as doublelayer as well as ions at the surface are confined in nanoc3 we aim to understand the effect of confinement of ions and of the doublelayer on charge storage and hydrogen production for this purpose we will analyze materials with unprecedented control of the pore size provided from collaborations with material scientists using innovative surface science techniques these measurements are enabled by the expertise of the er in microcalorimetry and of the host institution in spectroscopy and electrocatalysis to study confinement of the doublelayer gold electrodes with tuneable slits will be provided by serge lemay twente nl gold is a wellstudied model electrode to investigate the doublelayer and hydrogen evolution allowing for comparison of the results with literature data theoretical calculations will be performed by alexei kornyshev imperial college ukto obtain the even smaller pore sizes necessary to study ion confinement mos2 and v2o5 electrodes will be provided by s fleischmann kit ger these layered materials can be tuned by intercalating molecular pillars leading to an increase of the interlayer spacing mos2 can be used to substitute the expensive pt in the hydrogen evolution while v2o5 is a wellresearched sc exhibiting ion confinementin summary the goal of nanoc3 is to advance the field of electrocatalysis in a new and yet unexplored direction
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positive geometries in the real world
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our understanding of the fundamental laws of nature is based on the study of scattering amplitudes traditionally computed using feynman diagramsin the past three decades the shortcomings of this representation have become increasingly clear scattering amplitudes enjoy a simplicity which is destroyed by feynman diagrams resulting in an overwhelming apparent complexity of computationsthis has motivated the search for alternatives to feynman diagrams which culminated in the discovery that scattering amplitudes in two toy theories maximally supersymmetric yangmills theory and the simplest theory describing colored scalars can be computed as volumes of positive geometries regions in kinematic space carved out by inequalitiesin the new representation it is the usual properties kept manifest by feynman diagrams locality and unitarity which are now obscured while the simplicity of scattering amplitudes is restoredthese developments are both conceptually intriguing and practically useful
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enhancing copernicus security services eu governmental crisis management hub for forced population displacement
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addressing critical challenges such as population displacement due to conflicts exacerbated by factors like climate change extreme weather events food shortages and poverty remains paramount the implementation of theia integrating data fusion processing and analysis particularly leveraging geospatial artificial intelligence geoai and machine learning is poised to enhance the efficacy of existing services significantly through the amalgamation of multitemporal data and diverse datasets theia empowers better decisionmaking and adapts to evolving policy and user needs this technological advancement bolstered by geoai augments detection capabilities and ensures timely access to crucial information bridging the gap between capabilities and stringent security demands by integrating nonspace data and enduser intelligence theias supply chains add value not only at the operational level but also at regional and local levels facilitating improved coordination furthermore theia catalyzes fostering euindependent capabilities and technologies thereby bolstering the european space ecosystems consolidation and ensuring the sustainable coexistence of legacy and newspace solutions its services cater to a wide array of endusers including eu entities such as satcen and frontex member state ministries of defence intelligence agencies police forces nato and potentially extraeu national and supranational entities such as the united nations
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reconstructing fragmented bones reconstructing fragmented lives
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human skeletal remains can offer key information on diverse aspects of past life but like all archaeological materials they only give a glimpse into the life of past individuals hence a fragmented perspective into our ancestors lives their interpretative potential is greatly inhibited by the fact that such remains are often found fragmented due to several anthropogenic and natural taphonomic agents such as funerary treatment animal activity soil pressure and others this fragmentation severely limits the information that may be extracted from human bones in terms of metric analysis geometry and morphology reconstruct aims at producing 3d morphable models for the main elements of the lower and upper limbs of the human skeleton which will be then used to infer the missing morphology of fragmented or incomplete bones in order to achieve this aim and address a major current limitation in human skeletal analysis reconstruct will integrate approaches from osteoarchaeology forensic anthropology biology engineering and data science the results of the project will maximize the information that may be extracted from bioarchaeological research contributing to a more comprehensive assessment of past life parameters reconstruct will also have major implications in forensic anthropology since the study of modern skeletal remains suffers from similar limitations in terms of partial preservation as those witnessed in archaeological bones finally the source code and raw data emanating from reconstruct will be made open access greatly enhancing the extension of this approach to zooarchaeology palaeoanthropology and the prosthetic implants industry
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european twinning for research in solar energy to 2 water h2o production and treatment technologies
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while the largest resource to avail is saline water desalination faces two main challenges to its sustainability the energy consumption required for the process and the waste residual brine that can have a serious environmental impacts whereas the combination of solar pv with reverse osmosis or solar thermal heat with distillation processes has been developed along the recent decades into commercially available solar desalination solutions the innovative integration of brine valorization and zero liquid discharge zld concepts aims at developing strategies to close the material loop minimizing the liquid waste the integration of these technologies results in a zld solarpowered desalination system a circular economy scheme with the production of fresh water and recovery of valuable resources from the waste of the processgathering the experience of three nonwidening top partners presenting some of the most outstanding background and research infrastructure ri at european level in the development of solardriven water production and wastewater treatment technologies wpwt sol2h2o aims at supporting the coordinator widening partner in the development of establishment of highlevel research in this field based on the outstanding widening ri and background in solar energy technologies and on its preliminary experiences in the waterenergy nexus field sol2h2o seeks the development and implementation of a common scientific strategy with a strong focus on an enhanced capacity building of researchers going beyond purely scientific capacities and strengthening their research management and administration skills by means of a common research strategy aiming at further developing solardriven waterenergy nexus solutions sol2h20 aims at creating a reference european facility for the development and testing of circular solardriven water production treatment technologies enabling the development of renewable gas or agriculture activities
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eoscentrust a european network of trusted research environments
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the mission of eoscentrust is to create a european network of trusted research environments for sensitive data and to drive european interoperability by joint development of a common blueprint for federated data access and analysis countries and institutions have made significant investments in secure and trusted data environments to meet the need for research and policydriven analysis of sensitive datasets such as peoples health and socioeconomic status the habitats of vulnerable species and geospatial locations of protected sites there are now a large number of such secure environments in operation linked to national centres individual organisations or specific research communities this fragmented landscape poses challenges for both users and providers researchers are faced with a large number of different systems and access procedures providers need to manage federated access across multiple potentially incompatible technology and governance frameworkseoscentrust brings together providers of operational trusted research environments from 15 european countries with a shared goal to implement validate and promote their capabilities through a common european framework using shared standards and common legal operational and technical language this blueprint for interoperability is anchored in the eosc interoperability framework spanning the four dimensions of legal organisational technical and semantic interoperability eoscentrust has identified four driver projects covering genomics clinical trials social science and publicprivate partnerships to benchmark capabilities inform blueprint design and demonstrate secure data analysis using federated workflowstargeted outreach activities will expand this open network with further providers and develop policy papers and guidelines for the full range of stakeholders to create a longterm operational tre framework within the european open science cloud
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marperwise submarine permafrost and seafloor geomorphic change in the canadian beaufort sea
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submarine permafrost a vital component of the arctic environment plays a significant role in geological and environmental processes however critical knowledge gaps persist necessitating comprehensive investigations our project manperwise seeks to address these gaps and enhance our understanding of this dynamic phenomenon despite advancements uncertainties surround the extent thickness and degradation of submarine permafrost in the arctic manperwise aims to quantify these aspects within a designated study area employing a stateoftheart controlledsource electromagnetic csem system developed by the university of malta one key objective is to unravel the intricate relationship between permafrost degradation and seafloor geomorphic changes with a specific focus on seafloor instability by analysing data acquired through our csem system and comparing it with seafloor morphology we aim to elucidate the mechanisms driving these transformations furthermore manperwise envisions the development of a conceptual design for a remotely operated vehicle rovbased or autonomous underwater vehicles auvsbased csem instrument this advanced tool will enable highresolution repeat mapping of submarine permafrost and submarine groundwater discharge sgd such innovation promises transformative insights into the arctics evolving dynamics dissemination efforts encompass scientific publications research conferences seminars a dedicated project website and engagement with policymakers and the general public guided by prof charles k paull mbari prof aaron micallef university of malta and prof mark everett texas am university manperwise addresses critical knowledge gaps in submarine permafrost dynamics offering insights with implications that extend beyond the arctic region to global climate processes
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does standardization matter evaluating the potential of the common european framework of reference for languages cefr for reducing employment discrimination faced by immigrants
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around 57 million people in europe are foreignborn developing strategies for inclusive growth and devising actions to promote immigrant integration through nondiscrimination are among europes current priorities this project will evaluate if the common european framework of reference for languages cefr which is used to standardize host country language requirements for different professions throughout europe can serve as an effective tool to reduce hiring discrimination against immigrants employers have been shown to discriminate against immigrant applicants based on languagerelated bias which can be reduced when language requirements are specified in cefr terms based on a novel design that combines realworld variation in the inclusion of cefr requirements in job ads with a factorial survey experiment and indepth interviews among employers the project will address three objectives 1 examining if the inclusion of cefr requirements reduces differential treatment of immigrant applicants on aggregate 2 identifying labor market areas and ethnic groups that benefit most from the introduction of cefr requirements 3 assessing the current implementation of cefr requirements in relation to uninformed or inadequate use results and the collected data set will be distributed among the scientific community open access among the general public science fairs and among employers and county governors webinars roundtable discussions and can serve as a steppingstone for developing comprehensive and adequate language requirements for different professions at the international level the projects unites expert researchers in sociolinguistics and language test development with an early career researcher ecr specializing in immigrant integration and languagebased discrimination into an interdisciplinary team this will provide impactful training to the ecr who will benefit from methodological training project management experience and network ties
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an integrated theory of deciding and acting
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how do we translate information from sensory inputs and memory stores into goaldirected actions in the last 40 years the fields of cognitive psychology and cognitive neuroscience have focused on the decisionmaking stage and very few attempts have been made to understand the complete process the aim of the present scientific proposal is to elaborate an integrated computational theory of deciding and acting in humans which explains conflicting measurements from these traditionally separate fields of research and provides joint precise quantitative predictions about them the core hypothesis of the theory is that motor execution is determined by the same evidence accumulation variable that drives decisionmaking this hypothesis strongly departs from current models of decisionmaking that represent motor execution as a residual parameter under the assumption that motor execution captures effects that are not cognitively interesting the theory will be tested through a series of experiments that combine cognitive modeling behavioral and electrophysiological measurements electromyography of responserelevant muscles and electroencephalography specifically the experiments aim at i testing and characterizing the hypothetical dependency of motor execution to the evolving decision variable ii generalizing the theory to a wide range of choice laboratory tasks and different response effectors iii identifying potential boundary conditions of application and iv elucidating the relationship between decisionmaking motor execution and confidence judgments in a final part of the project the theory will be applied to developmental data in order to provide new theoretical insight into the development of decisionmaking and motor execution across the lifespan if successful this work should provide new perspectives into a broader range of research problems from perceptionaction coupling to movement disorders that appear to have a cognitive basis
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reversibly operating fuels cells for clean energy and longterm storage
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the main innovation of reverion is a patented 2 patents already granted 4 submitted and other 6 planned disruptive new system architecture design for high temperature fuel cells or solid oxide cells socs we are not producing the socs but purchasing those from established soc manufacturers the individual subcomponents of a reverion system are commercially available however the system design meaning the arrangement and use of the components and the control algorithms of the closed cycle are brand new and highly innovative it leverages synergies no other product can achieve such as the unprecedented efficiencies by combining reversible solid oxide fuel cells with a twostage offgas recovery we can achieve a complete fuel utilisation and recordbreaking efficiencies 80 electrical efficiency for power generation and an even higher efficiency in electrolysis mode energy storage powertogas production of hydrogen or biomethane as desired
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trustworthy planning and scheduling with learning and explanations
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planning and scheduling ps is a core area of ai its aim is to build systems that assist humans in planning organising and optimising courses of action to achieve complex objectives despite the pressing need for decisionsupport systems for ps applications in industry and public services current approaches do not satisfy essential properties of trustworthy ai such as transparency explainability robustness safety and scalabilitytuples is a 3 year project aiming to obtain scalable yet transparent robust and safe algorithmic solutions for ps the cornerstones of our scientific contributions will be 1 combining symbolic ps methods with datadriven methods to benefit from the scalability and modelling power of the latter while gaining the transparency robustness and safety of the former and 2 developing rigorous explanations and verification approaches for ensuring the transparency robustness and safety of a sequence of interacting machine learned decisions both of these challenges are at the forefront of ai researchwe will demonstrate and evaluate our novel and rigorous methods in a laboratory environment on a range of usecases in manufacturing aircraft operations sport management waste collection and energy management our results also include practical guidelines derived from the lessons learnt in this process and opensource software tools and test environments enabling the humancentered development and assessment of trustworthy ps systems expected outcomes include increased productivity decreased environmental footprint and the empowerment of workers in the above sectors these could translate into huge economic environmental and social impacts if trustworthiness ends up driving mass adoption of psthe tuples consortium includes worldleading researchers in several fields of ai ps constraints machine learning explanations humanities and social sciences psychology law ethics and experts of their applications
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quantum sensing with van der waals heterostructures based on hexagonal boron nitride
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the project idea is to implement a new quantum probe based on hexagonal boron nitride hbn containing spin defects to study the properties of artificially stacked twodimensional 2d materials and devices the essential building blocks of such van der waals vdw heterostructures are the quantum defects in hbn recently discovered by the pi and his team these intrinsic lattice defects negatively charged boron vacancies vb can be optically spinpolarized and coherently manipulated allowing the readout of quantum information during the coherence time our experimental approach is based on coherent manipulation of the spin state using highfrequency pulse protocols followed by optical readout to explore the adjacent environment in particular by studying the local lattice strains pressure temperature and magnetic fields the unique feature of hbn is its nondisturbing chemical and crystallographic compatibility with other vdw materials which gains a new fundamental functionality with the embedded spin centres and allows sensing in heterostructures serving as a boundary itself optical readout will be extended by electrical control of spin and charge states which is an unexplored area and a major step forward in the development of quantum applications of vdw heterostructures we focus on i the enhancement of vb emission and spin resonance contrast by coupling with plasmonic resonators to identify single defects never seen before ii the identification of the sources of spin decoherence of these defects in particular the interaction with other electronic defects and hyperfinecoupled nuclear bath and their bypassing and iii the exploration of semiconducting and magnetic heterostructures and electronic devices based on them the project aims to establish 2d heterostructures as a flexible platform for new quantum applications based on the optical and electrical control of coherent states and mapping fluctuating external fields on the nanoscale
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orchestrating nextgeneration mobile modular laboratories for pandemic monitoring preparedness
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expert opinion from across the world recommends calls for modular laboratory systems to be made available for disease monitoring missions the who calls these rapid response mobile laboratories rrml onelab will develop modular rrml for rapid flexible scalable multiscenario deployments into the widest range of possible settings these nextgeneration facilities will support nextgeneration measurementtechnologiesmethodologies and through satellite communications form widearea gis enabled laboratory information systems thus simultaneously providing pointofneed disease detection along with highlevel situational awarenessonelab will also develop advanced measurement systems for a staged disease detection response exploiting a panel of acute viral infection biomarkers enables early detection of disease during its asymptomatic incubation using this at the outbreak of disease when much is still undefined supports effective immediate targeted public health interventions additionally using proven methodologies developed in response to covid 19 onelab will develop demonstrate a workflow for semiautonomous disease specific biomarker discovery this application delivery of agile science enhances the capability capacity of current disease testingstrategies substantiallyrrmls are only as good as the skilled teams who operate them so onelab builds worldwide networks partnerships of experienced experts to define contextuallyaligned best practice develop a consensusdriven concepts of operation and disseminate this though a pandemic testing playbook we will develop capability capacity with training networkingevents that continue beyond the project finally community masstesting requires engagement acceptance from all citizens which is why we will engage with the public produce a citizens guide to mass community testing supported by educational outreach resources
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carbon sequestration in blue ecosystems
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cblues will significantly advance knowledge and understanding of blue carbon ecosystems bces seagrasses tidal marshes mangroves macroalgae and macroalgae mariculture aiming to achieve three overarching objectives 1 develop new scientific knowledge within bces to reduce scientific uncertainty and improve reporting of blue carbon under the united nations framework convention on climate change unfccc 2 provide input to a possible revision of the 2013 ipcc wetlands supplement to increase inclusion of coastal wetlands in national greenhouse gas ghg inventories and reporting 3 raise awareness and promote the role of blue carbon for delivering global climate policy commitments in collaboration with chinese and other international partners cblues will perform the following produce spatial maps methodological best practices and standard operating procedures enable more robust and reliable quantification of carbon emissions and sequestration model sequestration capacity and upscale regional and global ghg budgets assess carbon stock changes ghg emissions and removals related to different management interventions and human activities review legal and institutional frameworks governing bces and assess the drivers and barriers for integrating coastal wetlands into national reporting mechanisms under the unfccc cblues will target the following mission ocean lighthouse areas la la atlanticarctic la baltic and north sea and la mediterranean sea the black sea dutch antilles and through collaboration with china the southern china coast will also be covered cblues will engage with the scientific community climate and coastal policy makers and the wider civil society to disseminate the knowledge generated raise awareness of bces and build capacity for blue carbon research inclusion cblues will effectively impact national and international climate policy work so that bces more prominently are included in reporting and management actions
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new industrial process for footwear manufacturing using 3d bonding
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the 3d bonding project addresses a disruptive process based on a family of patents simplicity works pctes201207001369 for highly automated and robotised manufacturing of highend footwear through a polymer injection process we bond materials in 3d instead of stitching that creates a stable skeleton without overlapping seams in a few seconds this technology eliminates the need of complex stitching operations improving the mechanical properties foot the footwear adaptation comfort and permeability 3d bonding simplifies footwear manufacturing reducing the total number of operations to 20 70 for traditional manufacturing reducing labour costs associated to stitching and assembly by 72 and using 50 less material moreover the carbon footprint is 13 less than a traditionally made product our 3d bonding project can bring back to eu the manufacturing process resulting in reduced delivery times multiple job positions and a stronger economy for the eu
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the lost manuscripts of medieval europe modelling the transmission of texts
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lostma aims at understanding how human cultures are constituted and evolve through the question of the transmission of written cultural artefacts it strives to establish in what measure the transmission and subsequent preservation or loss of written artefacts texts and ideas deviates from pure chance and if it deviates by how much and why it does it will do so by analysing the way that texts in manuscript form were copied transformed or destroyed in a similar way to the evolution of living organisms or of language variants through process of innovationmutation fixation or extinctionas such the goal of this project is not only to understand the processes behind the transmission of texts but also to grasp the extent to which humans are the actors of the transmission of their own culture and how much the survival of texts or the constitution of cultural canons are due to chanceif this notion may seem provocative to humanities researchers evolutionary biologists have long discovered the role of random drift in the survival or extinction of genetic traits and species to investigate this question this project will attempt a paradigmshift in philological methods by combining artificial intelligence complexity science and philological expertise stochastic birthanddeath processes and computer multiagent simulations will be used to emulate the process of textual transmission a case study will be taken regarding chivalric literature in european context supported by deep learning methods largescale data collection will be made on a corpus of 4000 documents in romance germanic and celtic languages with a fulltext zoom on approx 1000 old french manuscripts data will provide observable values to be compared to simulation results in order to measure deviations from chance make inferences on non observable values such as losssurvival rates of works and manuscripts and understand the dynamics at work behind the transmission of texts
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integrated germanium quantum technology
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spin qubits in germanium have resulted in the most advanced semiconductor quantum processor within five years of development germanium qubits are established as a highly promising candidate for largescale quantum computing germanium is a standard semiconductor manufacturing material and germanium qubits are the only semiconductor qubits that are defined exclusively by transistorbased structures and has enabled to demonstrate a universal quantum gate set hen20 this is highly promising for scalability and adoption by leading semiconductor technology a revolution in the growth of strained germanium sparked a remarkable development which led to the first germanium quantum dot germanium qubit twoqubit logic in germanium fourqubit logic in a twodimensional array and operation of a 16 quantum dot array this program brings together all the partners that enabled these developments to form a consortium with leading scientists and industry to fulfil the promise of germanium quantum technology by scaling the number of qubits by designing architectures allowing to advance beyond 1000s of qubits and by experimentally implementing a computational task that can provide a quantum advantage the key objective of integrated germanium quantum technology ignite is thus to demonstrate that germanium defines a compelling platform for quantum computation with excellent qubits operating in a scalable network we therefore focus on four key components to demonstrate its success
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fingerprinting cold subduction and plate tectonics using key minerals
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plate tectonics pt is a wellestablished framework of moving plates made of oceanic and continental lithosphere the main driving force of this system is the slab pull a force imposed as the older and colder subducting plate sinks into the asthenosphere at convergent boundaries producing low temperaturehigh pressure lthp metamorphic rocks although our understanding about pt has improved in the last decades there are major unknowns remaining namely when and how its onset took place a highly controversial topic the record of lthp metamorphic rocks becomes continuous only from 850750 ma onwards but recent evidence of these rocks at 21002000 ma suggests a similar tectonic regime operated at this time as well an outstanding question arises did plate tectonics as we know it today begin to operate only 850ma ago or did this change take place much earlier but disappeared as the result of a preservation bias affecting lthp rocks fingerpt will test this hypothesis using detrital minerals in sedimentary rocks that can track older lthp key minerals that can retain pressure temperature and age ptt information will be used applying chronothermobarometric tools through a multidisciplinary approach we will i combine the existing tools with new ones to obtain reliable ptt conditions ii test these tools and study the survival of eroded lthp terranes via mineral analyses in analogue modern sediments draining an exposed subduction zone iii identify and sample the most appropriate units whose detrital minerals record the last 1000 to 4000 ma to trace the secular evolution of cold subduction the emerging new tools from fingerpt some that push current technological boundaries will be widely applied by other petrologists establishing when modernday pt began will influence the geodynamic mechanisms proposed for the early earth eg sluggish tectonics forcing a shift of current conceptual models on the evolution of earth systems
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the role of structural genomic variants in ecoevolutionary processes
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genetic diversity is a fundamental level of biodiversity at a time of global change it provides variation that underpins species persistence and their adaptation to changing environments variation in the direction or presence of dna sequences has been largely overlooked until now yet those structural variants svs represent a key aspect of genetic diversity svs cover 3 to 10 times more of the genome than the wellstudied singlenucleotide variants and have different properties length effect on recombination mutation rate structural variation thus represents a quantitative and qualitative shift in our understanding of genetic diversity with predicted but understudied implications for evolutionthe project evolsv calls for a reassessment of the genomic basis of ecoevolutionary processes my ambition is to lead new research avenues on the impact of svs in ecology and evolution and to determine the contribution of svs to current biodiversity i will combine cuttingedge genomics and powerful experimental approaches developed throughout my career to perform multidisciplinary research on a focal system coelopa flies and then across taxafirst i will investigate svs within a population genetic framework in coelopa spp to determine how sv properties affect their distribution and effects on fitness second i will assess the contribution of svs to deleterious load in a case of range shift northwards third i will examine how svs contribute to phenotypic adaptation focusing on parallel climatic gradients and rapid thermal variation fourth at a broader phylogenetic level i will draw general principles about the evolution of structural genetic diversityevolsv will have longterm impacts by providing the first comprehensive assessment of structural genetic diversity across the tree of life developing the study of svs in nonmodel species and determining how genetic architecture contributes to evolutionary response in a rapidly changing world
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waste quantification solutions to limit environmental stress
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the wasteless project will develop and test a mix of innovative tools and methodologies for food loss and waste flw measurement and monitoring a bottomup approach will be followed starting from defining an harmonised methodological framework and set of standards for the testing activities the evaluation of the tools implementation and the quality and integrability of the data produced in other frameworks and finally recommend sustainable policies and business strategies to set the ground for a harmonised framework at eu level additionally to the measurement and monitoring tools wasteless will carry research activities on innovative processes and streams to valorise unavoidable flw with the ambition to make existing flw quantification solutions and wasteless ones usable by all food actors it will be developed a decision support toolbox for any stakeholders to access to the most appropriate methodology digital tools and solutions for flw valorisation all that aggregated with the environmental and socioeconomic impact associated to the implementation of the solutions this will enable the replication of data collection hubs accross europe feeding the model developed by jrc with robust reliable and comparable flw data
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extreme ultraviolet ptychographic microscopy
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this project extreme ultraviolet ptychographic microscopy xuvpm aims at improving the robustness and resolution of multispectral extreme ultraviolet xuv ptychography by realizing novel types of high divergence structured illumination in xuv spectral range in this microscope twocolor generation of highorder harmonics from an industrial grade femtosecond laser will be employed to create structured illumination with controllable degree of orbital angular momentum oam to be combined with ptychography the highrepetition rate and highaverage power femtosecond laser source will be temporally compressed with pulse postcompression and then split into two beams the weaker beam is used to generate the second harmonic in a nonlinear crystal this forms a twocolor interferometer where each arm contains a spatial light modulator slm to individually imprint oam into each beam both beams are directed and focused into a noble gas jet in a noncollinear scheme to obtain highorder harmonics with controllable oam the oamhhg beam consisting of multiple harmonic orders is focused onto the sample by two toroidal mirrors in wolter configuration the sample is scanned transversely and at each scan position a ccd camera records the diffraction pattern the generated xuv radiation will be optimized for its divergence and spatial properties where the oam can be controlled by the settings of the individual slms for the two generating colorsthe fundamental research on the described illumination technique will offer a chance to investigate the resolution limit of tabletop xuv microscopy which further can address imaging science challenges associated with eg the fabrication synthesis and integration of nextgeneration quantum and semiconductor devices the work is supported by two experienced supervisors from complementary fields covering the whole spectrum of the proposed project
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the malignant glioma immunooncology matchmaker towards datadriven precision medicine using spatially resolved radiomultiomics
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adult and paediatric malignant glioma gbm and phgg remain among the most difficulttotreat cancers with 5year survival rates of 5 despite intensive standardofcare therapy the differences among patients and the heterogeneous and plastic nature of each individual tumour have resulted in all therapeutic clinical trials failing during the past 20 years recently immunotherapy has been showing great promise but only in subsets of patients identifying those patients cannot be done a priori as biomarkers are still largely missing nor are we able to followup on therapeutic efficacy when patients get treated the gliomatch project aims at improving the clinical outcome of gbmphgg patients by enabling immunologybased patient stratification to empower personalised matching of appropriate immunotherapy while improving followup of clinical responses to existingnovel therapeutics this will be achieved by integrating spatially resolved multilayered tissue maps using integrated singlecell multiomics with noninvasive mri images this integration will fuel into a novel mri radiomultiomics hub that will be made available to clinical professionals through which they can perform tumourhost based patient stratification and personalised therapy matching while interpreting longitudinal followup and treatment efficacy the proposed datadriven models will be developed by analysing the largest cohort of immunooncology io treated gbmphgg patients n300 including prepost treatment samples with matched controls n300 and exceptionally longterm surviving gbm patients n140 in which various tumourhost niches will be studied in how they respond to io perturbations and lead to improved clinical outcome this will be empowered by deploying an uncancompatible data lake to which incremental data collection will be used to further refine the machine learning models while proposing novel treatment options this action is part of the cancer mission cluster of projects on understanding tumourhost interactions
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how european big cities and legal systems trigger urban inequality an inquiry into law and economics
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habitat is based on a groundbreaking research hypothesis gbrh socioeconomic inequality in major european cities is largely due to a history of regulatory failures of urban legal systems urban legal systems have played a central causal role in concentrating wealth and conversely they have failed as much as the economic system in protecting vulnerable residents from growing socioeconomic inequality in major eu cities to test this gbrh the principal investigator pi and his team address the main forms of urban inequality from a law and economics perspective habitat measures the impact of laws and judicial decisions that by hypothesis have triggered urban inequalities european urban legal systems made middle and bottom deciles underprivileged minorities migrants and women worse habitat tests this gbrh through a case study approach considering berlin london milan and paris the pi proposes unprecedented and unique legal research grounded on rigorous data analysis and a robust cuttingedge methodology that combines a the evolutionary analysis of legal orders with a focus on the legal determinants of the built environment b the comparative analysis of the common core of urban legal systems c a regulatory impact assessment through econometrics statistics and data analysis d an evidence and process based normative model for the design of just cities from a legal and conceptual perspective tested through scenario analysis
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active mobility innovations for green and safe city solutions
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to reach carbon neutrality cities must adopt new more adapted energy models for urban mobility relying on zeroemission and active mobility modes the uptake of sustainable mobility solutions relies on their inclusivity affordability and safety as well as their consistency with users needs through cocreation activities and innovative digital tools the amigos project will identify present and future mobility challenges for 5 cities living labs and 10 urban areas safety improvement areas the digital tools include a mobility observation box and an application for the collection of new mobility data which will feed a big data platform for their analysis and digital twins to visualize mobility scenarios they will allow urban stakeholders to identify mobility challenges and will serve as a basis for the codevelopment of adapted mobility solutions towards reducing traffic increasing public and active mobility modes improving safety and cohabitation between different mobilities for the 5 cities and towards increased safety for the 10 urban areas therefore key stakeholders such as public authorities and vulnerable users will be included in the definition of technological and policy solutions mobility solutions which will be implemented in the cities their environmental safety economic and social impacts will be assessed in addition to their medium and longterm impact and their replicability in view of their implementation in 5 twin cities
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machine learning algorithm pipeline for endothelial damage detection and adverse outcome prediction
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endothelial cells form the lining of the blood vessels of the entire vascular system from the heart to the smallest capillary regulating vascular tone immune response and exchange of materials in and out the blood stream among others endothelial damage has been observed in the early stages of most cardiovascular diseases atherosclerosis or in patients with iflammatory and infectious diseases eg covid19 septic shock typically endothelial damage is measured by means of blood test analysis and provocative tests either invasive performed by using pharmacological agents or noninvasive such as flow mediated dilation that on the other hand suffer from high operatorindependency and noautomatization this proposal revolves around the design development and validation of a supervised machine learning algorithm ml to evaluate endothelial damage and predict adverse outcome in critically ill patients in the icu the ml pipeline will use as input data the one from the horizon 2020 project vascovid clinical validation these data comprises of physiologically relevant variables that can be measured noninvasively with a completely automatized platform this smart platform combines diffuse optics and an automatized tourniquet for performing a reactive test on peripheral muscle thenar muscle by means of this device it is possible to access in an accurate and robust way information about early impairment in perfusion metabolic rate of oxygen consumption and microvascular functionality and tissue capability of locally regulate the blood flow these variables bring an important physiological insight concerning the interpretability of machine learning algorithm from the clinical community who does not fully trust this approaches
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ribosome heterogeneity as a determinant of cellular identity in hematopoiesis and leukemia
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differentiation and acquisition of cell identity are fundamental processes in multicellular organisms it is well established that chromatin and rna mechanisms regulate cell fate determination mounting evidence from our lab and others however suggests that translation is an additional until now underappreciated determinant of cell fate the importance of translation to differentiation can be gleaned from the hematopoietic system where a prominent feature of human congenital syndromes due to mutated ribosomes is aberrant blood production crucially these mutations lead to distinct celltypespecific differentiation defects rather than systemic failure it remains unclear how congenital totalbody ribosomal mutations only affect particular differentiation paths and manifest in a celltypespecific fashion we hypothesize that celltypespecific ribosomal compositionie ribosome heterogeneityresults in celltypespecific translation profiles and therefore represents a crucial layer of gene regulation in cellfate and differentiation we will explore this hypothesis by pursuing three complementary objectives 1 systematically map ribosome heterogeneity and reveal its function in normal hematopoiesis and leukemia 2 determine how ribosome heterogeneity controls celltypespecific translatomes and contributes to cellular transformation and 3 explore ribosome heterogeneity at singlecell resolution using novel methodologies we will develop for simultaneous transcription and translatome interrogation by combining cuttingedge sequencing techniques with extensive genetic manipulations in physiological settings we will reveal celltypespecific translation controlled by celltypespecific ribosomes as major regulators of cell fate in health and disease understanding the mechanisms of celltypespecific translation will provide a new paradigm for elucidating gene expression regulation and for revealing new mechanisms for human diseases
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ultrafast topological engineering of quantum materials
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topological phases of matter emerge from the interplay between broken symmetries and manybody physics and exhibit many fascinating quantum phenomena ultrafast switching between different topological phases using light pulses holds the promise for disruptive optoelectronic functionalities like dissipationless and faulttolerant logical operations however the lack of proper observable being simultaneously sensitive to the local in momentumspace topology of the band structure and compatible with timeresolved measurements prevents the realtime monitoring of ultrafast nonequilibrium topological phase transitions i will address this fundamental challenge by introducing innovative control and measurement methodologies using tailored light pulses in time angle and polarizationresolved extreme ultraviolet photoemission spectroscopy this approach will enable to follow the ultrafast evolution of the electronic band structures local topology in photoexcited quantum materials this will represent a major advance in photoemission spectroscopy by moving from band structure mapping to accessing the dynamical evolution of the bloch wavefunction of solidsi will use these novel time and quantumstateresolved dichroic observables to investigate the rich nonequilibrium physics underlying ultrafast topological phase transitions occurring on various timescales following impulsive optical excitation using shaped pump pulses i during the formation of hybrid lightmatter floquetbloch states ii upon the transient modification of electronic correlations and iii following the excitation of coherent phonon modes utopiq will deliver a dramatically improved understanding of the interplay between the nonequilibrium behaviour and nontrivial topology in photoexcited quantum materials while further representing a decisive step towards the development of the field of ultrafast on demand topology
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artcast4d unleashing creativity
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advances in immersive technology are an important driver of the experience economy enhancing the breadth depth and intensity of the visiting experience at arts and cultural institutions yet they usually are neither readily available nor broadly accessible first they require specific developments that can hardly be carried out by most institutions second the inherent affordance of immersive propositions is questioned by the currently evolving world health situation the objective of the artcast4d project is to develop a technological framework and tools that will unleash the potential of eu ccis for designing and developing costeffective noninvasive immersive and interactive users experiences using both academic and industrial approaches it relies on theoretical and experimental research open source software and hardware development together with challenging case studies and onsite beta testing implementations the innovation lies in the ability to create immersive environments in open spaces with minimally intrusive projection technology on the capability to design interactive applications with crowd movement and sensing capabilities and on the open source availability and ability to extend the solutions artcast4d will technically and financially promote the implementation of the technology outside the cultural institutions implementing 4 pilots in cities around the world issylesmoulineaux hounslow valencia athens each one with different artistic topics and experiences and bringing together creative actors and industrial partners with the civil society all pilots will include training workshops and open training modules will be designed for developers and artists the projects outcomes will also help to derive policy guidelines on how to strengthen the competitiveness and innovation potential of ccis on national level and eulevel
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centre of excellence for precision medicine in pediatric care
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the vision of the pmpc centre of excellence for precision medicine in pediatric care project is to position the childrens clinical university hospital ccuh in latvia at the leadingedge of pediatric precision medicine research and care in europe precision medicine has proven its potential to revolutionize healthcare by tailoring treatments to individual patients based on their unique genetic makeup environment and lifestyle factors while it has shown promise and delivers results in adult populations its potential in pediatric care is largely untapped our goal is to improve pediatric patient care and outcomes by establishing a new research centre of excellence coe at ccuhs campus for research on and adoption of innovative precision medicine approaches in an integrated and collaborative research innovationcareeducation rice environment to this end ccuh will teamup with europes leading institute in pediatric precision medicine the princess maxima center the netherlands maxima has an extensive precision medicine program and uses advanced translational research and treatment expertise in many areas including cart cell therapies and pediatric clinical trials the coe will provide an environment for transdisciplinary team science with international visibility in the field of pediatric precision medicine the center will leverage the latest advances in genomics cell therapies data science and computational biologyccuh has secured 20 million eur from private donors as a complementary part of funding together with the horizon europe grant the valuable knowledgetechnology transfer and active collaboration with the maxima team pmpcs unique value will be brought forward resulting in benefits for patients their caregivers researchers healthcare professionals and society it will strengthen ccuhs scientific and technological capacity in precision medicine enabling it to attain a competitive position in this promising field
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arithmetic of curves and jacobians
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the study of the arithmetic of curves is as old as mathematics itself and takes on many forms in some cases such as fermats last theorem or mazurs torsion theorem one tries to prove that a sequence of curves with growing genus has no interesting rational points in other cases such as the study of rational points in families of elliptic curves there is no way to classify all solutions but one tries to understand what is happening on average a third approach aims to link the existence of rational points on a given curve to the preponderance of points on the curve modulo larger and larger prime numbers this is the idea behind the birch and swinnertondyer conjecture and its generalization the beilinsonbloch conjecture the proposed research makes progress in each of the three paradigms above in corresponding order we propose a mazurtype theorem for a family of unitary shimura curves by exploiting the jacquetlanglands correspondence and a connection with prym varieties a special case of this result would give a classification of torsion points in a family of genus three bielliptic jacobians second we propose an approach to the poonenrains heuristics for elliptic curves by combining twisting methods with bhargavas geometryofnumbers methods for universal families using similar methods we aim to show that hilberts tenth problem has a negative answer over every number field third we study certain instances of the beilinsonbloch conjecture for the degree 3 motive of the jacobian of a curve with complex multiplication the strategy involves the construction of an euler system composed of cm ceresa cycles related work will explore torsion and infinite generation phenomena for ceresa cycles as well
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projectionbased control a novel paradigm for highperformance systems
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the field of control has been a key driver for major societal innovations in health mobility energy and manufacturing at present technological trends push the performance requirements for future applications to extreme levels that are far beyond current control solutions existing linear controllers for linear systems are supported by userfriendly time and frequencydomain design tools yet they lack the flexibility to overcome fundamental performance tradeoffs full nonlinear control structures provide the desirable flexibility but they lack comprehensive frequencydomain design techniques these observations indicate a lack of flexible control structures accompanied by systematic design and online optimization frameworks exploiting time and frequencydomain information to realize the unparalleled performance needs of future engineering systems in proacthis i will bridge this scientific gap by creating a new control paradigm based on projection operators by introducing projections in control loops specific signals are kept in wellchosen constraint sets inducing direct performanceenhancing benefits i foresee that the mathematical structure of these projectionbased controllers enables fundamental properties that were instrumental in the success of linear control and will be key to obtain effective design frameworks for this new class of hybrid controllers developing projectionbased control theory has high risks as even the mathematical formalization of these control schemes leads to a new class of dynamical systems never studied before this scientific challenge calls for leveraging powerful multidisciplinary methodologies from hybrid systems control engineering networked systems learning and mathematics successfully developing this new system theory will pave the way towards gamechanging cuttingedge control methodologies addressing the needs of future engineering systems thereby enabling new breakthroughs in important societal domains
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reactions in microdroplets accelerated by plasma
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chemical reactions are normally conducted in bulk solution in some cases the rate of such bulk reactions is quite slow limiting the throughput of a synthetic route in recent years a novel field of research based on microdroplet chemistry is emerging as an analytical tool for reaction monitoring as well as a mean for accelerating chemical reactions by using droplet chemistry reaction rates can be increased by several orders of magnitude compared to the bulk counterpart it is therefore beneficial to systematically investigate the reactivity of microdroplets and to understand the role of the underlying mechanism and individual parameters that can influence their reactivity eg ph temperature concentration and surface effects a better fundamental knowledge will make microdroplet reactions faster and allow for novel approaches to be developed the goal of my research proposal is to achieve a broader fundamental understanding of microdroplet chemistry and use this knowledge to investigate the novel field of plasmamicrodroplets interaction which is expected to open the doors for a completely novel chemical reactivity the highly reactive species generated by plasmas will be allowed to react with the highly reactive surface of microdroplets the possible outcome is a substantial increase in reactivity promoting reaction pathways normally not significant in bulk or even droplets by exploiting the unexplored field of plasmadroplets interaction i plan to identify reaction pathways that can significantly increase reaction yields of high addedvalue compounds aiming at more sustainable efficient and competitive industrial synthetic processes and at the possible conversion of existing waste products into chemicals which could still be useful for our society
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paradoxical activation of oncogenic signaling as a cancer treatment strategy
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cancer cell homeostasis requires a balance between activated oncogenic pathways driving tumorigenesis and engagement of stressresponse programs to counteract the inherent toxicity of such aberrant signaling indeed emerging evidence suggests that hyperactivated oncogenic signaling can also be toxic to cancer cells indicating that cancer cells select optimal levels of oncogenic signaling rather than maximal levels i propose here a fundamentally different approach to the treatment of cancer based on deliberate hyperactivation of oncogenic signaling combined with perturbation of the activated stress responses to selectively kill cancer cells we will use drugs that further activate oncogenic signaling in cancer cells protein phosphatase 2a pp2a inhibitors gsk3 inhibitors pkc activators dusp inhibitors and study the associated toxicities using single cell omics technologies we will then use crispr and compound screens to identify the vulnerabilities of such drugtreated cells this will identify effective combination therapies using this paradoxical approach we have delivered initial proof of concept for this notion by demonstrating that hyperactivation of oncogenic signaling in colon cancer by small molecule inhibition of pp2a combined with inhibition of the mitotic kinase wee1 results in dramatic antitumor responses in vivo most strikingly we found that cancer cells develop resistance to this therapy through selective downregulation of oncogenic signaling to evade the stress imposed by hyperactivation of oncogenic signaling consequently resistance to this hyperactivation therapy was associated with both reduced oncogenic signaling and oncogenic traits in vivo here we aim to understand and exploit toxicities associated with paradoxical activation of oncogenic signaling using multiomics technologies study how cancer cells can develop tumor suppressive drug resistance and address the effects of this type of therapy on premalignant lesions
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customs extended interoperable common information sharing environment
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connectors vision is to contribute to the european integrated border management eibm and to the eu customs action plan by addressing the need of close cooperation between customs border and coast guard authorities within the current and upcoming challenging and demanding environment of borders control by further involving customs to the common information sharing environment cise network and enhanced common information sharing environment ecise through the proposed customs extended common information sharing environment cecise connector aims for the first time to suggest an integrated common and shared risk assessment approach for all border management authorities considering the paneu common risk indicators per end user group customs border and coast guards authorities including frontex to ensure external eu border and secure eu citizens from crossborder crime andor secure the seamless flow of travellers as recommended in the multiannual strategic policy document thus in this sense connector proposal will design and develop the connector system as an interoperable technical environment ensuring close and practical cooperation and information exchange at all levels the design and the development of the connector system will be based on the analysis of current policy initiatives in eu level directives policy and staff documents guidelines etc along with needs gaps and future views of the enduser groups going beyond previous initiatives andromeda marisa effector etc complying with the societal ethical and legal soel requirements and regulations following the soelbydesign principle the connector system will be validated in real operational environment based on welldefined national crossborder and transnational use cases defined commonly by customs and border and coast guards authorities during three 3 long lasting trials demonstration and testing under standardised methodology
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