prompt
stringlengths 3
262
| response
stringlengths 12
3.91k
|
|---|---|
advanced sustainable biofuels production from purified microalgae and oleaginous yeasts via integrated solar hydrothermal liquefaction
|
sunfusion endeavors to comprehensively address a novel process of microalgae and oleaginous yeasts conversion into shipping and aviation biofuels by advancing stateoftheart core technologies i innovative pbr and open raceway ponds for microalgae and yeasts cultivation and optimization ii a concentrated solar thermal cstcoupled continuous hydrothermal liquefaction htl reactor with solar energy covering the thermal needs of the process iii a solaraided thermal energy storage tes system which at later stages will be fully integrated to the overall process iv hydrotreatment units to obtain the final advanced sustainable biofuels v recovery of gaseous and aqueous streams from htl and synergistic cultivations of microalgae and yeasts that will be recycled to the microalgae cultivation leading to a zero emission and zero waste process htl is a thermochemical process used for the production of sustainable biofuels from the depolymerization and repolymerization of highly moist organic biomass having the inherent advantage of avoiding the costintensive part of biomass drying these points will introduce highriskhighreturn novelties that will play an impactful role in forwarding the process subcomponents to trl 4 at least 7 l of biocrude from microalgae and 1 l from yeasts are planned to be produced and upgraded a testing period of above 12 months will take place under onsun conditions at temperatures exceeding 350oc with the solartobiocrude energy efficiency target set to exceed 50 which is an ambitious number that will allow the sustainable transformation of solar energy to energy carriers in the form of biofuels finally an overall process assessment will take place to evaluate the technology in terms of technical economic and environmental aspects the visionary concept beyond sunfusion project envisages the integration of the main components of the process in a mobile platform that will be operational in offgrid places
|
luxembourg hydrogen valley delivering integrated fullchain sustainable hydrogen ecosystem with technical economic social and environmental benefits and superior replicability
|
luxhyval launches a flagship hydrogen valley in luxembourg to boost the penetration of hydrogen by deploying green hydrogen initiatives across the entire value chain from local production to utilisation including storage and distribution for a range of applications targeting industry and mobility while also aiming to connect with existingplanned infrastructures business models regulation and commercial negotiations are defined safe design and operation are ensured to deliver certified green hydrogen luxhyval produces 650 tony that are used by several enduse applications in the mobility ie private public buses light industrial vehicles and industry ie metal and glass manufacturing sectors using 69 and 31 of the produced hydrogen respectively strong commitment of key commercial actors along the entire value chain and political support in line with the luxembourg hydrogen strategy aimed at fully decarbonising the industrial sector before 2030 is ensured as demonstrated by 80 cofinancing from external sources it generates different investments exceeding 38m significant econonomic social environmental and political impacts are achieved digital twinning for optimal planning and operation is delivered to support upscaling and replication while public perception and professional upskilling deliver social benefits and equip the workforce with the needed competences lastly the lessons learned and solutions are replicated in 2 follower valleys in central cz and eastern ua europe the consortium include 19 partners from 7 countries 6 from europe plus australia aligned with the clean hydrogen mission covering the entire value chain including energy engineeringintegrator network operators technology providers supplier of green electricity end users in mobility and industry and rto experts in digitalisation public acceptance environmental assessments innovation management and replicators from the follower valleys
|
empowering eu rural regions to scaleup and adopt smallscale biobased solutions the transition towards a sustainable regenerative inclusive and just circular bioeconomy
|
climate change will require concerted innovative ideas and actions at the localregional level a sustainable european bioeconomy will not only ensure the protection of the environment and biodiversity but will also drive the renewal of european industries the modernisation of primary production systems and lead to the creation of jobs particularly in rural areas through the active participation of all regional stakeholders in their local bioeconomies ruralbioup project will strengthen the cooperation among regional key actors and knowledge holders empowering them to establish an inclusive and longlasting ecosystem the ruralbioup regional hubs to support the mainstreaming of biobased business models in rural areas in particular ruralbioup will establish 9 regional hubs 30 stakeholders per hub in 6 eu countries that will codesign and implement 9 action plans on 18 value chains regional hubs will be empowered by ruralbioups partners with mentoring coaching and training activities in the implementation of their action plans thanks to this at least al 1000 innovators will be supported through networking events and study visits and al 50 new collaborations fostered eg partnership agreements between companies andor farmers solutions funded etc to adopt smallscale biobased solutions in rural areas the project will leverage synergies between existing eu networks eubionet bioeast etc clusters and regional organisations and will build upon previous research results power4bio berural enabling transition2bio biovoices etc by integrating and extending the existing knowledge and data in order to propose different rural business models and new biobased value chains in the targeted regions through the realisation of a digital tool the ruralbioup onestopshop supporting regional actors to take sciencebased and informed decisions
|
circular bioeconomy transformation for regions by enabling resource and governance networks
|
biotransform provides european policymakers with an adequate assessment and policy development framework knowledge base and expert support ecosystem to accelerate the transition from linear fossilbased systems to circular biobased systems it is therefore operating at the interface between the circular economy and the bioeconomy transitions in this way biotransform equips policymakers with the tools to set informed priorities that serve environmental economic and social goals being actionable futureproof and align with supplyanddemand trends in related industries and value chains biotransforms assessment package will be tested by and provided for european policymakers which will include 3 complementary tools i resource flow analysis tool including circular innovations ii a cuttingedge quick environmental social and economic assessment tool and iii a logistics management tool to achieve this biotransform develops and tests its framework to establish and roll out circular biobased systems by applying a multiactor approach around 6 regional cases andalusia spain northern burgenland austria western macedonia greece finland charles spa region czech repulic and north rhinewestphalia germany these regional case studies represent several important industries and scenarios for europe such as forestry agrifood lake ecosystems lignite and minerals and chemicals action roadmaps will consider specific regional available resources and infrastructures conversion pathways logistics current policies strategies and access to finance in other words biotransform builds on the concept of regenerative bioeconomy value cycles by tapping into what is there already and connecting the dots in this concept carbon is stored and nutrients are recovered this concept shall be upscaled and replicated to many further european regions to achieve europes ambitious goals
|
optimization of seismic structural health monitoring systems based on value of information analysis
|
infrastructure systems such as bridges are one of the most crucial and integral parts of civilization and substantially affect a nations economic social and strategic solidity considering europes aging infrastructure system most of them exposed to seismic hazard and the limited available resources effective maintenance management solutions become a must to ensure their safe operation structural health monitoring shm systems can improve the relevant decisions by reducing the uncertainty associated with the capacity of the monitored structure and with the demand induced by seismic events this project is directed toward the development of an advanced decision support tool for the optimal design of shm systems aimed to support the integrity management of bridge networks in seismicprone regions this novel decision support tool will take the basis on the value of information voi analysis it will exploit information about the capacity of the structure gained through structural health monitoring data and information about the seismic demand acquired through measurements and stateoftheart groundmotion simulations the project will advance the state of the art through the advancement of the framework for the quantification of the voi from shm for bridge networks in seismic regions the decision support tool will integrate advanced modeling of both the bridge capacity accounting for deterioration and of the seismic demand through 3d physicsbased simulation accounting for the complexities associated with the seismic source propagation path and site the outputs of the research will contribute to european added value through highquality research on the integrity management of bridge networks in seismicprone regions with the potential to contribute to the united nations sustainable development goals
|
hybrid nanocomposite scintillators for transformational breakthroughs in radiation detection and neutrino research
|
the goal of unicorn is to develop unprecedented nanocomposite scintillator sl detectors based on engineered nanomaterials for transformative breakthroughs in strategic radiation detection areas spanning homeland security and medicine to industrial nuclear and environmental monitoring to cosmology and high energyparticle physics today conventional inorganic sl crystals are prohibitively energyintensive fragile heavy and cannot be produced in large quantities organic sls are in turn affordable and scalable but their low density and light yield reduce energy resolution these shortcomings preclude progress in application areas of great importance and impose a technological bottleneck to the fundamental study of rare events the most at risk of all is the study of neutrinoless double beta decay 0dbd a so far undetected rare nuclear process that represents the holy grail in particle physics whose observation would provide long soughtafter answers on the origin of the universe and unlock unexplored scientific territories with unimaginable progress perspectives unicorn will tackle this urgent grand challenge by introducing revolutionary nanotechnologybased concepts combining high energy resolution efficiency and stability with unmatched mass scalability the keystone of our disruptive approach are inorganic nanocrystals ncs that will be specifically designed to be both the source of 0dbd and highperformance nanosls the breakthrough will also consist in achieving perfect compatibility with inorganic hosts to obtain unparalleled ultrahigh density opticalgrade nanocomposite detectors with maximized light output to be coupled to custommade light sensors that will embody the archetype of advanced radiation detectors of the future unicorn combines worldleading institutions and companies with complementary interdisciplinary competences ensuring the pivotal synergy to reach the project goals and rapidly translate results into economic value
|
rondelo the first medical stopcock designed for sequential intraveneous infusion of incompatible drugs
|
cyto365 is developing rondeo a revolutionary medical stopcock to be used with intravenous drug administration sets iv sets rondelo is the first medical device that allows for a sequential intravenous administration of up to 6 drugs with the neutral saline in between the drugs rondelo aids the nurse to administer drugs to the patient safely and correctly by letting only one drug pass at a time it solves the problem of serious side effects caused by drug incompatibility by eliminating human error and unwanted parallel infusion and thereby increases patient safety moreover rondelo is easy to use minimal training required safe for the user closed system valve csv minimizes hazardous drug expose for the nurse customizable different configurations with 2 4 or 6 drug inlets with or without csv available and timeefficient all drugs are connected to iv set at the beginning of the procedure
|
time is not on my side remembering victims of slow violence in a postconflict and postdisaster setting reslovi
|
what is happening when nothing is happening and how can we study events that are uneventful as a research field memory studies has mostly focused on violent events wars conflicts and particularly the holocaust and their public remembrance however the proposed project reslovi attempts to move away from studying public remembrance of conflicts and proposes an innovative approach to viewing the aftermath of violent events reslovi focuses on memories and experiences of displacement caused by a war and a natural disaster the projects main research objective is to rethink memory of suffering and violence in a postconflict and postdisaster setting by raising awareness of violence that is unspectacular happening out of sight and is not publicly remembered or even acknowledged as violence at all reslovi counters the mainstream theories of memory studies by employing an innovative theory of slow violence the project examines how people from a region in a postconflict and postdisaster country grapple with and remember the experience of displacement which is considered as a form of slow violence the project entails 3 key objectives 1 to contribute to innovative research on slow violence by studying its characteristics in a region of postwar croatia at the example of slowmoving transformations of the built environment that produced new vulnerabilities displacements 2 to introduce the slow memory theoretical approach into studying how memories of croatian populations displacement are triggered and reframed in the context of new displacements happening due to new crisis situations 3 to analyse the community response mnemonic solidarity to suffering and to contribute to research on political significance of citizens mobilization and agency in a postdisaster setting and in a postconflict context
|
quantifying aiinfused science
|
the recent the recent public release of artificial intelligence ai that can master natural language has sparked a debate about the capabilities of ai and whether it can produce scientific content despite the ongoing debate aigenerated written content has already entered the world of science papers cowritten by ai are published companies release models to assist scientists with producing scientific content and a large fraction of scientists use aibased tools to augment their writing we will thus inevitably have aiinfused science in our future the goal of scaience is to quantify whether how and with which implications generative ai is changing how scientists write communicate perceive and diffuse science and to rigorously explore the opportunities dangers and implications of scientists augmenting their science with ai the key hypothesis of scaience is that current ai lacks the ability to combine knowledge entities eg references in the same manner as humans and is unable to replicate the social information eg homophily or recency present in human scientific output testing the implications of this hypothesis is crucial since the scientific enterprise relies heavily on social information present in scientific output data for a wide range of purposes eg metrics definition information retrieval and predictions the scaience project will deploy a novel computational social science approach based on a wide array of quantitative disciplines leveraging large scale databases of humangenerated information and controlled experiments scaience will break new ground by i introducing the quantitative methods required to understand aiinfused science ii redefining metrics and models to account for aigenerated content in science and iii delivering quantitative scientific insights into how ai is changing the diffusion of science taken together scaience will lay the scientific foundation for the quantitative study of aiinfused science
|
finding the missing links in the bacterial cell cycle
|
the bacterial pathogen staphylococcus aureus is currently the second most common cause of death associated with antibiotic resistant infections the most useful antibiotics in clinical use have multiple targets as compounds against single proteins rapidly succumb to the capacity of bacteria to develop resistance to think innovatively about antibiotic discovery we need to think not only about individual cellular processes but also about how they are interconnected and coordinated so that we can devise methods to strike bacterial cells simultaneously in multiple pathways the bacterial cell cycle consists of a series of coordinated events required for bacterial growth during which cells duplicate their mass and undergo chromosome replication and segregation assembly of the division machinery cytokinesis and cell separation to generate two new daughter cells unregulated cell cycle progression may have lethal consequences for the cell and therefore bacteria have evolved various mechanisms for the precise spatiotemporal control of main cell cycle events some important checkpoints have been studied particularly the link between chromosome replicationsegregation and septum synthesis to avoid dna breaks however the mechanisms for coordination of other cell cycle events are still unknown what triggers initiation of peptidoglycan synthesis the target of betalactam antibiotics after assembly of the division machinery how does the cell coordinate synthesis of the membrane and peptidoglycan the two major cell surface components during cell division what prevents premature septum splitting which would expose an immature cell surface devoid of virulence factors leading to pathogen elimination by the innate immune system of an infected hostthe aim of this project is to find the missing links between major cell cycle events while also developing assays useful for antibiotic discovery
|
novel biomarkers for improving diagnostics prognostics and treatments of alzheimers disease
|
alzheimers disease ad is the most common cause of dementia and a major global health challenge ad has a long presymptomatic phase spanning several decades the accuracy of clinical ad diagnostics is mediocre especially in primary care this results in suboptimal treatment and care which is especially problematic in light of emerging antiamyloid therapies advancead aims to revolutionize ad diagnostics and prognostics and fasttrack the development of new effective therapies by using novel bloodbased biomarkers forbetaamyloid tau neurodegeneration and neuroinflammation first my team will transform the clinical workup of symptomatic ad patients globally by developing scalable noninvasive and costeffective diagnostic and prognostic algorithms based on novel bloodbased biomarkers and digital toolssecond diseasemodifying therapies should be initiated already in the presymptomatic phase to be very effective my team will therefore develop costeffective diagnostic algorithms to identify ad pathology in individuals without cognitive symptoms and prognostic algorithms to detect those most likely to develop symptoms and thereby benefit from new therapies these new algorithms will then be used to recruit individuals into a presymptomatic trialready cohort to efficiently evaluate new antiad drugsthird new drug candidates for our trialready cohort will be identified using largescale analyses of the novel adrelated biomarkers in biobanked longitudinal blood samples from already performed randomized placebocontrolled trials using this high riskhighgain approach we will evaluate if different classes of existing drugs eg statins glp1 agonists antiinflammatory agents can halt development of ad and neurodegeneration finally a novel genetic antitau treatment will be evaluated in this trialready cohort advancead builds on worldleading research and will likely result in breakthroughs in early diagnostics and treatments for ad
|
quantum devices and subsystems for communications in space
|
the protection of sensitive information is of crucial importance in our society the security of money transfer commercial transactions medical data remote control of critical infrastructures power grid telecom etc are key assets for eu citizens quantum key distribution qkd is a promising solution to protect digital communications guaranteeing unconditional security based on the laws of quantum mechanics rather than on the computation capability of an adversary qkd requires a satellite network to allow the sharing of random keys between two legitimate users at the european scale the main target of qudice is the development of the components and subsystems for quantum communication and optical systems for spacebased qkd enabling the realization of a european network of satellites with quantum key distribution as the main service specific objectives of the project include the development of a trl6 spacequalifiable source for discrete variable dv qkd the development of a trl56 spacequalifiable quantum random number generator qrng the development of a trl6 spacequalifiable satellite pointing and tracking pat system the development of a trl56 spacequalifiable entangled photon source eps the development of a trl56 spacequalifiable continuous variable cv qkd source the development of a trl6 spacequalifiable onboard 5g system for qkd postprocessing support and qkdsecured connectivity service the development of simulations and testbeds to assess quantum satellite communications components the definition of the roadmap towards trl9 for the developed systems
|
new era of guided lens implantation in cataract surgery
|
akknateks devicebased solution is introducing a unique imaging technology to overcome the current hurdles of nowadays cataract surgery it is designed to offer full control over the lens position at any point of the treatment for the first time guaranteeing best possible results for every lens implanted the solution consists of a set of 3 modules which also can be used independently preoperatively the diagnostic system for patient screening allows detection of capsular bag dislocation calculates the optimum lens design and eliminates iols not suitable for the respective patient to reduce the need for potential resurgery right from the start during the surgery the imageguided system enables realtime monitoring of the iol placement and computer assisted guidance to ensure accurate placement based on the visual axis after surgery the postoperative diagnostic system measures the iol position and if needed helps the surgeon realign the iol as it may move after surgery
|
global lingua franca a transnational history of french 18001870
|
golingua contrasts the french languages relative decline across postnapoleonic europe against its prominence as a global lingua franca among new elites who came increasingly in contact with european space from 1800 through 1870 by focusing on the outward spread of the language from paris to the countrys modest empire researchers have lost sight of the female speakers and isolated elites from many areas who adopted french to connect with a globalizing world my research recovers the stories of nonnative french speakers from many regions in order to propose a new transnational framework for the study of the history of language recent histories of global french begin their accounts in the final third of the nineteenth century when the french colonial empire expanded beyond algeria i challenge this consensus by showing how speakers outside french space learned the language in a much earlier period shared communications in french created a longlasting form of social cohesion that stretched across national and imperial borders the project will lead to two peerreviewed articles on the ways that various groups used french in three locations haiti germany and russia my grant will give me new skills in the russian language and quantitative discourse analysis which will be applied to conduct research in german french luxembourgish and american archives a secondment in france will allow me to attend french cultural events in paris before returning to trier to meet institut français officials working in frankfurt and luxembourg a writing project developed out of these meetings will communicate the global significance of my research by uncovering the polyvocal origins of global francophonie i demonstrate the importance of multilingualism for a cosmopolitan european identity today
|
a foundation for empirical multimodality research
|
this project lays a foundation for conducting datadriven empirical research on multimodality that is how human communication and interaction rely on combinations of modes of expression theories of multimodality are rapidly gaining currency in diverse fields concerned with human communication interaction and cultural production however most theories of multimodality are based on conjecture and remain without an empirical foundation due to the lack of large richlyannotated multimodal corpora and methods for their analysisfoundations solves this problem by developing a novel methodology for conducting empirical research on multimodality in everyday cultural artefacts such as newspapers textbooks magazines and social media videos this methodology allows critically examining key theoretical concepts in the field medium semiotic mode and genre and their joint contribution to meaningmaking which renews our understanding of key theoretical concepts in multimodality research and places their definitions on a solid empirical foundationto do so foundations creates large and reproducible multimodal corpora using microtask crowdsourcing which breaks complex tasks into piecemeal work and distributes this effort to nonexpert workers on online platforms these crowdsourced descriptions are combined with computational representations into graphs that represent the structure of multimodal discourse for analysing these corpora the project develops novel methods based on neurosymbolic artificial intelligence which enables combining crowdsourced human insights with the pattern recognition capability of neural networksthe groundbreaking theoretical and methodological advances in foundations go far beyond state of the art by enabling largescale empirical research while preserving analytical depth needed for multimodality research this opens up new domains of inquiry for studying multimodality across cultures situations artefacts and timescales
|
developing compassionate workplaces in europe for the digital and green work environment to protect employees mental and physical health and wellbeing
|
eucowork aims 1 to explore and understand the influence of changing workplace organization due to the twin transitions on wellbeing performance job quality and work culture for employees confronted with serious illness family caregiving death dying and loss eol experiences and their colleagues and 2 to develop and evaluate tailored compassionate workplaces programs cwps as health promotion strategies to maintain and support employee health and wellbeing in the work environment across different national and labour contexts in europe the core of this project is a 4country crossnational mixedmethods intervention study with an embedded process and impact evaluation the project consists of 2 separate studies that feed into each other a an international cocreative and developmental evaluation of tailored cwps and b an international mixed methods process and impact evaluation combining a timed series of quantitative crosssectional panel surveys qualitative interviews and fieldwork and policy document analysis tailored cwps will be developed in 12 european workplaces eucowork will provide findings about workplace compassion and mental and physical health and wellbeing of european employees in several working sectors and the relationship between workplace characteristics and compassion at work and the health and wellbeing of employees confronted directly or indirectly with eol experiences the project will collect data about the relationship between employees eol experiences the companys responses to these experiences and company and employee performance and about the variability in workplace policies in europe that address such risk factors eucowork will thereby offer insights and building blocks needed to create work environments that ensure adequate support and policy and that are tailored to counterbalance experiences that may otherwise exacerbate the risk for adverse mental health and wellbeing outcomes for employees
|
miniaturized robotic systems for autonomous insitu exploration of critical raw materials in deep land deposits
|
minotaur seeks to address the exploration drilling problem from a novel and revolutionary perspective bringing together geological principles and concepts involved in exploration drilling with modern technologies such as robotics digital twin technology and artificial intelligence along the way minotaur proposes novel research directions in allied areas like geophysics sensing technologies in geology environmental impact modeling of whole mineral and production systems numerical modeling of entire mineral systems related to critical raw materials new drilling techniques highresolution sensing technologies and artificial intelligence with novel data processing tools for a robust and expeditious geological assessmentminotaur takes a fundamentally fresh look at exploration drilling and approaches it as a source seeking and resourcing mapping problem drawing inspirations from solutions in robotics but where geology is a central part of the decision with the outcomes of exploration enhanced through artificial intelligence and digital twin technology
|
sensing aberrant transcription by myc multimers
|
deregulated expression of myc or one of its paralogues mycn and mycl maintains the growth of most human tumors all current models explain the oncogenic potential of myc proteins by their ability to form complexes with max that universally bind to active promoters and the ability of these complexes to induce a tumorspecific gene expression pattern while myc conforms to this model during unperturbed cell growth we have discovered two paradigmatic situations in which myc proteins undergo fundamental changes in their biochemical state association with max and localization on chromatin in response to pharmacological or physical disruption of transcription elongation myc moves away from active promoters to form large spherical multimers that surround stalled replication forks these multimers contain transcription termination factors and form a zone that shields stalled forks from rna polymerase second mycn forms high molecular weight complexes during the s phase of the cell cycle that do not contain max and like myc multimers contain termination factors their assembly depends on rna that is normally degraded by the nuclear exosome arguing that they too form in response to aberrant transcription the switch between heterodimeric and multimeric states depends on nonproteolytic ubiquitylation of myc which alters proteinprotein interactions that retain myc at promoters our data show that myc proteins exist in a hitherto unknown dynamic equilibrium between globally promoterbound heterodimers and multimers that form locally in response to perturbed transcription we aim to show that these dynamics enable tumor cells to cope with stress arising from deregulated transcription and are crucial for mycs oncogenic function we expect that inhibiting myc multimerization will maintain normal growth but block the ability of tumour cells to cope with deregulated transcription and is therefore a valid therapeutic strategy for targeting oncogenic functions of myc
|
systemeu fostering systemic innovation and digital transformation across european innovation ecosystems
|
systemeu is an initiative aimed at transforming european innovation ecosystems through open innovation by fostering digitalization in healthcare energy and mobility it unites five regional ecosystems fostering inclusivity and collaboration among universities incubators public organizations government agencies and innovation centers from germany romania bulgaria bosnia and herzegovina and spain systemeu addresses the issue of traditional innovation efforts limited focus on societal and environmental transformation introducing a systemic and longterm perspective by fostering a collaborative and interdisciplinary environment systemeu will enable adaptable policies and stimulate economic vibrancy enhancing societal wellbeing and advancing european innovation systemeu promises to create interconnected inclusive and more efficient innovation ecosystems strengthen crossborder network collaboration through six crossregional projects in project duration and others after the project end expand global cooperation through existing networks of european actors and ecosystems promote gender equality and reduce territorial inequalities in access to innovation support aligning with eu policies and strategies systemeus innovative approach aims to usher europe into a regenerative world
|
accelerating proteins innovators beyond regulatory sandboxes
|
in the coming decades society faces the formidable challenge of providing sustenance for a global population expected to reach 10 billion by 2050 fortunately the burgeoning field of biotechnology holds significant promise in addressing this challenge by revolutionizing food production the central aim of this proposal is to pave the way for the widespread adoption of an innovative technology known as cellular agriculture which is poised to play a pivotal role in facilitating the global protein transition cellular agriculture in essence represents a breakthrough methodology for producing a spectrum of sustainable food productslead by 8 organisations from 7 countries representing the innovation ecosystem aprovals aims to facilitate the seamless integration of emerging cellular agriculture technologies into the global food landscape through two main activities sandbox for innovation aprovals offers a dedicated sandbox environment where innovators can test and refine their solutions this sandbox acts as a fertile ground for experimentation enabling startups and smes to develop their technologies and bring them to market interconnected stakeholders the project places a strong emphasis on fostering collaboration among key stakeholders involved in cellular agriculture1 startups and growing smes these enterprises are provided with essential support to advance their technologies and successfully navigate the journey from innovation to market2 innovation support tailored support initiatives are crafted to mitigate risks associated with the innovation process fostering a conducive ecosystem for cellular agriculture innovation3 regulators and policymakers aprovals actively engages with regulators and policymakers to establish robust protocols and a legal framework this framework serves to safeguard the market and consumers while simultaneously preventing unwarranted regulatory hurdles that could impede progress in cellular agriculture
|
responses of cetaceans to natural and anthropogenic noise
|
in the marine environment motorised vessels are now the most ubiquitous and pervasive anthropogenic noise source and the evidence for deleterious impacts from this noise source on sensitive marine life such as cetaceans whales dolphins and porpoises is mounting however cetaceans have not evolved in silent or naturally quiet environments and it may be hypothesised that animals have developed mechanisms to cope with naturally fluctuating noise levels regardless studies have yet to investigate whether individual cetaceans perceive and respond to motorised vessel noise in the same way as acoustically similar and significant natural noises such as rain for which they have been exposed to over evolutionary timescales in rain i will for the first time compare the responses of harbour porpoises a small odontocete cetacean to both motorised vessels and rain noise rain will 1 quantify the absolute contributions of rain and vessel noise to local marine soundscapes experienced by populations of harbour porpoises using longterm passive acoustic monitoring data 2 assess and compare the behavioural and acoustic responses of individual harbour porpoises to these noise sources using stateoftheart acoustic recording tags dtags and 3 investigate the effect of rain and vessel noise on individual echolocation performance as a proxy for foraging performance through rain i will provide new insights into how harbour porpoises perceive and respond to natural and anthropogenic noises at population and individual scales and identify quantify and compare potential coping mechanisms they employ to deal with these different noise sources results from rain will in turn providing evidence which will be used to directly inform the management of underwater noise levels and the protection of a key marine species in european marine waters
|
correlationsoriented representation learning
|
deep learning methods have propelled many of the recent remarkable achievements of artificial intelligence yet their inner workings remain enigmatic how do these methods represent the training examples in their multiple processing layers how are these representations used to make decisions on previously unseen data the correlationoriented representation learning coral project delves into the intricate relationship between data correlations and the hidden representations of deep neural networks corals core objectives encompass i characterizing the structure of data correlations in tasks where deep learning methods excel ii providing a theoretical description of the interplay between the learning dynamics of deep networks and data correlations and iii validating these theoretical insights on benchmark machinelearning datasets the researcher will approach these objectives with an effective mix of numerical experiments scaling descriptions and rigorous arguments inspired by statistical physics and fostered by the unique interdisciplinary scientific community of sissa by describing the impact of data correlations on representation learning coral holds the potential to enhance the interpretability and efficiency of deep learning methods across diverse domains while also enhancing our general understanding of the principles of learning from examples
|
the next generation of green resilient and socially inclusive smart cities
|
regreeneration is a publicprivate consortium including 9 european cities that will design experiment together for 4 years nature based solutions to regenerate deprived neighbourhoods for climate resilience ges reduction and local ecosystem dynamization through participative methods a set of mixed skills covering architecture landscape design geomatics and digital twins project value modelling urbanism nature public space facilities sociology economics will be deployed in different projects in paris fr barcelona es alverca pt bucharest ro followed by replicators located in roma it gent be ljubljana sl segrate it lappeeranta fi projects are complementary and will contribute to create a replicable knowledge on a large set of cities challenges how to regenerate quality of life health and attractiveness in marginalized areas bucharest paris how to capture carbon create freshness islands preserve biodiversity make a better usage of water develop low carbon mobility continuity prepare resilience to stressed weather events alverca barcelona paris how to educate and make local actors inhabitants municipality agents local businesses political authorities participate to design maintain the green areas created the nine cities how to analyze the diversity of local contexts to choose the right best practices to replicate in a european territory and define the required investment governance model roma gent ljubljana segrate lappeeranta the knowledge to successfully create for meeting these challenges will focus on some key concepts 1 creation of an indepth territory analysis unifying multiple planning domains and able to simulate evolution scenarios 2 extensive use of 15 mn methodology and pedestriangreen mobility focus to support life quality and impacts analysis 3 permanent integration of local climate resilience challenges at each key milestones of the project
|
digital health in circular economy
|
dice aims to develop and demonstrate novel circular and environmentally sound solutions to design collect directly reuse refurbish remanufacture and recycle digital health devices epaper label smart wearable sensor smart pill box endocutter which will contribute to enabling a circular transition solutions will be implemented tested and demonstrated in five healthcare ecosystems reflecting the geographical spread within europe through communityengaged pilots in norway belgium slovenia spain and germany dice will contribute to mitigating the globally expanding health waste problem covering three material streams electronics plastics metal and alleviate shortage of critical and valuable raw materials while protecting the health and safety of those involved in realising the circular economy exploitation of key outputs will be ensured by all partners throughout and after the project and will be further extended to adjacent sectors through existing networks and platforms within which the partners are represented
|
deciphering metastasis of lung cancer to brain and developing new therapeutic approaches via a human metastatic cascade platform
|
brain metastases have a poor prognosis and are associated with a high morbidity and mortality rate in cancer patients the metastatic pathways and the role of the bloodbrain barrier bbb during metastasis are not known there is a need to better understand cancer brain metastasis and develop effective therapeutics with metabrain i will create a humanbased in vitro platform that spans the entire cancer cell journey from lung to brain and use it to address three key questions 1 how does cancer metastasize to the brain 2 what is the role of the bbb in cancer metastasis to the brain and 3 how and when can cancer metastasize be treated the metabrain will provide answers to these questions by developing a truly physiologically relevant human cellbased model that for the first time maps the entire cancer metastasis cascade and that can also be used to study novel target proteins at the bloodtumor barrier btb this model will also be used to develop novel shuttle systems for drug delivery to the brain by integrating stateoftheart technologies from life sciences and engineering metabrain has three main objectives 1 develop an in vitro model that recapitulates the metastatic cascade with in vivolike morphology and function to study how cancer metastases to the brain 2 investigate the role of extracellular vesicle ev and circulating tumor cell ctc migration events with a focus on their interactions with brain endothelia and 3 identification of novel target proteins specific to cancerous brain and development of novel nanoshuttle systems targeting these proteins to deliver therapeutics to the brain in summary metabrain will lead the way in the development of physiologically relevant models for other braininvasive metastatic cancers open new avenues for the development of therapeutic and diagnostic approaches and pave the way for nanoshuttle formulations specifically designed to overcome the bbb and btb
|
which moral influences on european penal and prison policies
|
the justpen project aims to analyse the strategies private interest groups use to try to influence european penal and prison policies through notably litigation and judicial complaints lodged with the european court of human courts and the court of justice of the european union in relying notably on a current national research grant on the european human rights justice under moral influences the justpen project will analyse whether or not the moral and religious values promoted by these private interest groups have influenced and have even been taken account of or even been adopted by the european penal and prison policies in this respect the project will investigate the ways in which these private interest groups try to influence these policies using doctrinal judicial notably through litigation and monitoring efforts and political tactics in terms of effects of these strategies we will investigate how and to what extent these tactics are translated into penal and prison policies notably through a process of coercive human rights that refer to the coercive aspect the enactement of criminal law and the use of criminal sanctions of human rights protection in doing so we will propose a new theoretical model the moral entrepreneur of jurisprudence that is all about powerful private actors who do not behave as philantropists but are driven by material interests taking creative initiatives which involve shaping or reshaping case law on penal and prison policies in doing so they can either reinforce or on the contrary moderate and even lenify the coercive dimension of human rights and contribute though this process to orient significantly penal and prison policies the justpen project intends thus to achieve a significant paradigm shift within the existing literature on human rights european law and penal and prison policies by combining all these domains that are ignored by the existing legal sociolegal and criminological literature
|
advanced high pressure and costeffective pem water electrolysis technology
|
direct production of highly pressurised hydrogen from electrolytic water splitting can allow saving relevant amounts of energy compared to downstream gas compression the aim of this project is to develop a novel polymer electrolyte membrane pem electrolyser able to produce hydrogen at very high pressure 200 bar thus reducing the postcompression energy consumption another goal is to develop a costeffective technology allowing to achieve largescale application of pem electrolysers a significant reduction of capital costs is achieved by critical raw materials minimisation developing cheap coated bipolar plates and operating the electrolyser at a high production rate while assuring high efficiency about 80 vs hhv and safe operation advancepem aims at developing a set of breakthrough solutions at materials stack and system levels to increase hydrogen pressure to 200 bar and current density to 5 a cm2 for the base load while keeping the nominal energy consumption 50 kwhkg h2 reinforced aquivion polymer membranes with enhanced conductivity high glass transition temperature and increased crystallinity able to withstand high differential pressures are developed for this application the approach is to operate the innovative membrane at high temperature 90120 c under high pressure to allow increasing energy efficiency to mitigate hydrogen permeation to the anode and related safety issues efficient recombination catalysts are integrated both in the membrane and anode structure the new technology is validated by demonstrating a highpressure electrolyser of 50 kw nominal capacity with a production rate of about 24 kg h2day in an industrial environment the project will deliver a technoeconomic analysis to assess reduction of the electrolyser capex and opex the consortium comprises an electrolyser manufacturer membrane and catalyst supplier an mea developer and an enduser for demonstrating the system
|
dynamic resilience assessment method including combined business continuity management and cyber threat intelligence solution for critical sectors
|
the scope of dynamo is to combine the two fields of business continuity management bcm and cyber threat intelligence cti to generate a situational awareness picture for decision support across all stages of the resilience cycle prepare prevent protect response recover professionals of different backgrounds will work together with endusers to develop refine and combine selected tools into a single platform in alignment to enduser needs human factors high ethical standards and societal impacts dynamo includes the following goalsresilience assessment as basis for bcm an assessment with different levels of detail offers with varying existent data a fast or detailed evaluation of the investigated sector and helps to identify critical processes enduser data will be integrated to measure determined performance targets with respect to the functional description aibased approaches will be used for a deeper understanding and potential selflearning of the interconnected process the results generate knowledge concerning susceptibility and vulnerability of the investigated sector the solutions support the bcm with respect to the five resilience phases leveraging cti cti will be improved with respect to existing solutions h2020 echo panacea the h2020 early warning system ews will be extended and integrated a malware information sharing platform misp will be used to raise the situational awareness between different security actors the cti approach deliver data that will be integrated into the resilience and bcm approach the use of ai will support the development solutions will be integrated with the cyber knowledge graph to visualize the analysis of threat intelligencethe dynamo platform will be able to collect organizations skills data elaborate and create custom tailored organisational training to improve organisational resilience which will be demonstrated within three different crosssectoral usecases
|
corporate political power how business actors define the rules that govern their responsible behaviour
|
in this cuttingedge project i ask the research question how do business actors define the transnational rules that govern corporations responsible behaviour extending insights from political science and management studies the central objective of this research project is to enlarge the scope of actors activities and processes being studied and reveal more nuanced ways through which corporations exert power in and over political rules this main objective is operationalized into four working packages wp1 aims to synthesize the existing literature on corporate power in and over rules the other wps elucidate three indirect and often overlooked types of corporate political power ie power in and through global production networks gpns wp2 big four consultancies wp3 and trade associations wp4 to this end i create a novel dataset of national and international governmental csr policies from different countries international organizations and regional organizations in all major world regions spanning a 65year period by drawing together data from different online platforms in wp2 i measure the similarities between different governmental csr policies based on cosine similarity as a result of backward and forward gpn participation in wp3 i code the authorshipof these csr policies and the degree of similarities with publications by the big four consultancies in wp4 i send out a largescale survey to trade association representatives to ask about their lobbying on the csr policies within my dataset to further unpack the causal relations of wp3 and wp4 i also conduct indepth interviews by drawing on management theories on how companies govern global markets and political theories on the functioning of governments i ambitiously move this research agenda forward in an interdisciplinary manner this helps to overcome the treatment of either business or politics as blackboxes while also bridging the analytical macromicro divide
|
urban biography of a cosmopolitan african capital
|
the project aims at writing an urban biography of tungul old dongola sudan the use of the native nubian designation of the city underscores its medieval african heritage while the biographical approach aids in conceptualizing the city as a complex living organism tungul was originally the capital of the kingdom of makuria which transformed into a citystate under the patronage of funj sultans 16th19th cent makuria was a medieval african kingdom that thrived in the middle nile valley from the end of the 4th cent to the late 15th cent ce this project is a multidisciplinary attempt at gaining a profound understanding of settlement persistence in riverine africa and it intends to amass extensive documentation of a medieval and premodern city the biography will be based on analyses of tunguls urban design and planning built structures material culture bioarchaeology as well as micromorphology and geochemistry the results will significantly contribute to the nubian datasets and offer new perspectives for broader archaeological and theoretical studies on urbanism and complex societies the proposed biography will focus on three entangled and mutually inclusive research themes the capitals cityscape its design and planning the citys inhabitants climate and environment the project intends to venture beyond the traditional narratives steeped in either ecological or political determinism to create a balanced narrative devoting equal attention to climatic environmental socioeconomic and political factors the majority of work will focus on the collection and analysis of data on tungul in the makurian period 4th15th centuries however the research objectives require combining this material with data for the funj period 16th19th centuries which constitutes an outcome of the erc starting grant umma and with other information obtained through decades of excavations to consolidate the results of all research conducted at tungul
|
central european advanced therapy and immunotherapy centre
|
progress in biomedical science enables scientists to use a whole new toolbox to treat significant groups of diseases such as inherited rare diseases or diverse rare cancers advanced therapy medicinal products atmps apply recent advances in genomics cell biology andor gene editing to deliver truly personalized curative options the project proposes to establish flagship atmpfocused facility on the margin of academia and clinics central european advanced therapy and immunotherapy centre creatic at the masaryk university mu in brno czech republic mu will team up with the leading european research institutions 1 fraunhofer institute for cell therapy and immunology izi 2 leipzig university which together forms a significant cluster of research excellence in research development and training in the fields of gene and cell therapies and 3 copenhagen university with unique expertise in biomedical innovation law intellectual property biomedical ethics privacy and regulatory framework and health technology assessment combining stm and ssh disciplines the project will allow for i fundamental expansion of the scope of the ri activities of all partners to build multidisciplinary excellence facilitating the delivery of atmps to patients who need them ii establishment of the high level of decisionmaking autonomy for the creatic which will allow significant organizational and management changes creating spirit and conditions for cuttingedge research and innovation in the centre and iii strengthen the smart specialization of the czech republic ris3 cz 20212027 in the domain of advanced medicine and drugs through the involvement of actors from the academic public private and societal sector our approach reflects research priorities and societal challenges outlined in the pharmaceutical strategy for europe which proposes bedside manufacture of highly individualised medicines as a future trend in treating rare diseases with atmps
|
postbiotic restoration of the metabolome of moms
|
microbial dysbiosis can lead to behavioral changes including aggressive behavior mice treated with antibiotics exhibit increased aggression as do offspring of mothers given antibiotics only during pregnancy or alternatively only when nursing promising results from our lab in flies and mice support our hypothesis that such behaviors are partially affected by gut bacteria and associated metabolic compounds pregnancy is associated with reduced immune function and women receive antibiotics during this period for a myriad of reasons preclinical trials and clinical research suggest strong effects of these treatments on offspring a postbiotic to be taken daily in a manner similar to prenatal vitamins following antibiotic use during pregnancy and breastfeeding can restore microbiota form and function towards alleviating changes in offspring behavior throughout our ercfunded research behaviome our approach to exploring the innovation potential of our research is a stepwise process a direct result of this process was the identification of the erc proof of concept as a viable route to defining the early commercialisation steps and obtaining internal support to develop and implement the project within promom we aim to complete two critical objectives significant progress on technology development poc demonstration in vivo pilot data and achieving business readiness market research business plan enduser engagement the outcome of the erc poc will enable us to take the last step precommercialisation developing market readiness for commercialization our plan is to set up a spinoff company that will develop several postbiotic leads either through funding raised through venture capital or codevelopment with other larger companies in the field with promom we will develop a postantibiotic supplement that promotes maternalneonatal microbiota restructuring and reduces behavioral disturbances in the critical first 1000 days of life
|
biogeography and resilience of intertidal southern ocean communities
|
the intertidal zone seashore is a critical environment at the interface of marine and terrestrial habitats where interlinked environmental and anthropogenic stressors occur in polar regions especially in the southern ocean biological communities living in the intertidal zone remain largely underexplored understanding the diversity and biogeographic relationships existing among intertidal communities would prove central for deciphering their origin and evolution it is also crucial to assess their vulnerability to global changes as the southern ocean is currently facing fast pace environmental changes biorisc aims to evaluate the biodiversity biogeography and resilience of intertidal communities at an unprecedented spatial scale across the antarctic and the subantarctic by using an integrative communitybased approach the project will address fundamental ecological questions involving the assessment of biogeographic regions the importance of environmental heterogeneities and the evaluation of community resilience to climate change scenarios the work will combine standardized in situ protocol with thorough taxonomic identification and genetic methods dna barcoding and metabarcoding of several genes to produce an unprecedented dataset for community structure analyses in addition biorisc has a strong conservation component including the monitoring of nonnative species the results will fit the needs of nature managers at both the regional crozet falkland kerguelen islands and global scales convention for the conservation of antarctic marine living resources ccamlr altogether biorisc will therefore provide a critical assessment of the uniqueness of these communities and test how their composition and distribution are likely to shift in the future based on ipccderived scenarios of climate change
|
protect and promote crop wild relatives
|
crop wild relatives cwr are wild plant species genetically related to cultivated crops their untapped diversity can enhance resilience to biotic and abiotic stress and the nutritional quality of modern crops wheat sugar beet and oilseed rape were selected by prowild because of their importance to food security and eu farmers and because some of their wild relatives are endemic to europe moreover these cwrs constitute a rich and underexploited resource needed to face challenges linked to climate change and the transition to lowinput agriculture the genetic diversity and vulnerability of these cwrs must be better characterized to optimize their conservation and utilization the objectives of prowild are to identify priorities for insitu conservation of the selected cwr gene pools to survey and complement cwr genebanks collections and to increase the use of cwrs in crop improvement prowild associates 18 partners from 11 eu and associated countries with expertise in ecology conservation genomics pathology microbiology plant breeding agriculture and sociology prowild will compile and analyse cwr occurrence maps and perform new insitu collections it will predict the vulnerability of several cwr species and populations to ongoing climate changes exsitu collections will be complemented with endangered cwrs accessions prowild will investigate the resilience of cwr collections for relevant biotic and abiotic stresses the identification of cwrderived desired traits and their transfer into elite backgrounds will be done to promote cwr use overall prowild specific goals will be coordinated with input from breeders farmers and consumers prowild outcomes will contribute to european green deal initiatives through research education and training it will serve the eu biodiversity and the farm to fork strategies by preserving characterizing and utilising wild species that have unique importance for the resilience of our food systems
|
digitalization of cultural heritage as discursive practice mapping the museums and citizensled initiatives in graz and novi sad
|
digitalization of cultural heritage as discursive practice mapping the museums and citizensled initiatives in graz and novi sad disculther examine how the process of digitalization of cultural heritage dch identified on a discursive level manifests in two kinds of settings institutional museums and activist citizensled initiatives the main objective of the project is to investigate the plurality of discursive practices of dch within mentioned settings the innovativeness discrepancies and tensions in these practices as well as the capacity of dch to make accessible mobilize and critically engage citizens in opening the space for intercultural dialogue it is a project with comparative dimension on two levels it compares the institutional with noninstitutional practices of dch but also the processes in two cities novi sad serbia and graz austria they share in part the common history culture and heritage in contemporary framework comparison aims to highlight social and cultural experience of the cities of which one belongs to the state member of european union and one is in the process of europeanization it is also interdisciplinary research that transcends the boundaries in social sciences between sociology heritage studies and digital humanities and foregrounds hitherto neglected aspects of the process of digitalization of cultural heritage
|
unveiling the role of histone marks in metabolic memory storage and transmission
|
type 2 diabetes t2d is a multifactorial disease affecting over 450 million people in europe alone amounting to the burden of lifethreatening diseases and worsening quality of life skeletal muscle is affected early in t2d and contributes to the fast decline of wholebody glucose homeostasis which is called insulin resistance interestingly even when isolated from the body and cultured in a laboratory in nondiabetogenic conditions the skeletal muscle cells do not lose the characteristics of the donor ie the cells remain insulin resistant indicating the existence of a cellautonomous mechanism that retains the metabolic memory across generations of cells nonetheless such a mechanism remains elusive accumulating evidence suggests a potential role of histone posttranslational modifications as essential vectors of inheritable information but it is still a matter of intense debate in this project to address this question and understand the pathology of t2d we will trace a comprehensive genomewide map of histone posttranslational modifications induced by t2d in human primary skeletal muscle cells and investigate whether these histone marks can store and transmit information about the metabolic phenotype from the donor to the next generation of cells targeted studies using pharmacological and genetic interventions will then address the role of histone modifying enzymes in metabolic memory transmission the outcomes could lead to a novel understanding of a broader system of cellular memory storage and transmission by characterizing the disturbances caused by diabetes in the epigenome using stateoftheart techniques and multidisciplinary approaches we could pave the way for innovative clinical interventions addressing a critical global health challenge
|
coming to terms proof theory extended to definite descriptions and other terms
|
the project is concerned with two areas which so far have rarely come together complex terms and proof theory extendd focuses on definite descriptions as the most important and troublesome singular terms and on sequent calculus and its generalizations as the most important tool of modern proof theory since russells on denoting regarded as a paradigm of analytic philosophy definite descriptions occupy a central place in philosophical research and many deep and detailed studies have been carried out the second half of the 20th century saw the development of new approaches to this phenomenon based on nonclassical logics in particular free logic in which contrary to freges and russells classical logic it is not assumed that every term refers yet despite the long history of research into definite descriptions a paradigm of formal logic has so far rarely been applied to them proof theory the methods developed by gentzen in particular those relating to his sequent calculus provide the means for the deepest study of proofs and their properties yet only a small effort has so far been put into the adequate treatment of definite descriptions in this framework the same counts for other complex singular terms such as set abstracts and number operators extendd fills this important gap in research applying the methods of proof theory to definite descriptions is profitable to both sides competing theories of definite descriptions and complex terms in general their advantages and shortcomings are shown in a new light the behaviour of complex terms needs subtle syntactical analysis and requires enriching the toolkit of proof theory extendd deals with both challenges it develops formal theories of definite descriptions and modifies the machinery of proof theory to cover new areas of application the realization of extendd affects significantly the field of proof theory automated deduction and philosophy of language
|
recyclable materials development at analytical research infrastructures
|
a radical shift to the circular economy is urgently needed to cope with the challenge of finite resources decreasing at a frightening pace while the quantity of waste increases alarmingly the european commissions ec circular economy action plan ceap adopted in march 2020 has identified seven key product value chains that must rapidly become circular given their environmental impacts and circularity potentials this requires substantial research on materials with a very high recycling capability while exhibiting competitive functionalities in remadeari the most significant european analytical research infrastructures join forces to pioneer a support hub for materials research facilitating a step change to the circular economy remadeari offers coordinated access to more than 50 european analytical research infrastructures comprising the majority of the facilities that constitute the analytical research infrastructures in europe arie network remadeari offers comprehensive services suiting any research focusing on the development of new materials for the circular economy in the key areas highlighted in the ceap and plays an important role in the preparation of the common technology roadmap for circular industries senior scientist facility experts and highly trained young researchers contribute scientific knowledge and extensive support to realise a user service of unprecedented quality making each promising idea a success particular attention is attributed to the implementation of attractive formats to support researchers and developers from industry the comprehensive service catalogue is complemented by an extensive training programme communication and dissemination activities are underpinned by a continuous impact assessment which also enables evidencebased decisionmaking in the context of the proposal selection routes to sustainability of the platform will be explored towards the end of the project
|
spectral geometry of higher categories
|
the overarching goal of this project is to reveal and systematically study the geometry of important categories in homotopy theory algebraic geometry and representation theory to this end we will introduce and develop the framework of higher zariski geometry in which commutative rings are replaced by ringlike categories as the fundamental objects the resulting theory simultaneously generalizes modern algebraic geometry derived algebraic geometry as studied by lurie and tonvezzosi as well as balmers tensor triangular geometry while introducing entirely new global objects and methods in particular it provides a canonical spectral decomposition of a large class of higher categories over their balmer spectrum which is then used to produce powerful new tools to tackle some of the most important conjectures in their respective fields firstly we will construct a higher analogue of the tale topology and tale homotopy types for such categories giving rise to refined computational tools via descent this machinery will be applied to modular representation theory to give a complete description of the group of endotrivial modules for any finite group and any field extending the celebrated work of carlsonthvenaz and completing a program that began about 50 years ago secondly we will introduce a categorical analogue of the beilinsonparshin adles in particular bringing to bear techniques from the pointset topology of spectral spaces applications include significant progress on greenlees conjecture on algebraic models for gequivariant cohomology for a general compact lie group g which has remained open for more than 20 years thirdly building on our earlier work on higher ultraproducts we will study compactifications of categories and plan to combine these with recent advances in arithmetic geometry to make progress on the rational part of hopkins chromatic splitting conjecture one of the most important open problems in homotopy theory
|
unruly entanglements of sociomaterial change knowledge and power in energy frontiers
|
energy is foundational to climate change adaptation and mitigation goals but the present moment requires more than clean power plants energy frontiers are entangled in uncertain geopolitics injustices environmental change and development efforts raising the stakes for research on sociomaterial change unruly aims to create a paradigmshifting new analytical framework of change one that transcends disciplinary conceptual boundaries to hold the social and the material together theoretically and methodologically grounded in justice issues the project has four objectives innovate a new theory of sociomaterial change through unruliness create new research methods to analyse sociomaterial change advance empirical research on energy frontiers and reframe what requires governing in unruly contexts unruly creates a novel theoretical basis for understanding how power materialises through uncertainties knowledges uneven social relations colonialism racism class patriarchy and governance challenges methodologically the project is carefully designed to build towards the higherrisk highgain dimensions the work will contribute fresh insights on hydropower energy frontiers in two case studies nepal and zambia and develop new methods capable of analysing variables and processes defined as inherently sociomaterial the results aim to tease out an analytical basis for democratic debate on the tension between efforts at prediction and governing change and uncertainty and unruliness which can derail those efforts the pi will lead an international crossdisciplinary research team comprised of two postdoctoral fellows two phd candidates three research affiliates and an advisory board of international academic leaders boldly challenging existing research conventions on sociomaterial change and reimagining novel approaches to our shared planetary crisis
|
precision drug repurposing for europe and the world
|
here we a group of longstanding collaborators in innovative drug repurposing propose to build repo4eu a comprehensive europeanglobal platform for validated precision drug repurposing open to stakeholders for information multimedia training matchmaking and cooperation drug repurposing reduces the time and costs of drug development but is often serendipitous and less effective than classical drug discovery both discovery and repurposing suffer from the same knowledge gap that diseases are mechanistically not understood and treated symptomatically in an imprecise manner our team of worldleading scientists overcome this by breakthroughs in advanced bioinformatics and artificial intelligence ai on realworld big data to redefine diseases in a mechanismbased manner patients are still identified by symptom but stratified according to causal mechanism the endotype trials are small precise innovatively designed prioritising in coordination with regulators payers and investors patientdefined outcomes with high safety and operational excellence this revolutionary new era of medicine will allow unprecedented efficacy and costeffectiveness the promiscuity of small molecules and recently expanded knowledge of protein structures are exploited by cheminformatics and deep learning to repurpose drugs beyond their original target at any level of the development chain even for classic projects repo4eu provides expertise and matchmaking for freedomtooperate intellectual property reformulation and valuecreation specialised in drug repurposing within 5 years repo4eu will establish a firstinclass coherent and innovative webbased platform for safe and efficient drug repurposing for all types of high unmet medical need indications to all european researchers and smes with a unique open science concept ensuring global medical impact finally within a 2year interphase repo4eu will be converted into a sustainable european infrastructure
|
logics and algorithms for a unified theory of hyperproperties
|
the central role of information technology in all aspects of our private and professional lives has led to a fundamental change in the type of program properties we care about up to now the focus has been on functional correctness in the future requirements that reflect our societal values like privacy fairness the central role of information technology in all aspects of our private and professional lives has led to a fundamental change in the type of program properties we care about up to now the focus has been on functional correctness in the future requirements that reflect our societal values like privacy fairness and explainability will be far more important these properties belong to the class of hyperproperties which represent sets of sets of execution traces and can therefore specify the relationship between different computations of a reactive system previous work has focussed on individual hyperproperties like noninterference or restricted classes such as khypersafety this project sets out to develop a unified theory for general hyperproperties we will develop a formal specification language and effective algorithms for logical reasoning verification and program synthesis the central idea is to use the type and alternation structure of the logical quantifiers ranging from classic firstorder and secondorder quantification to quantifiers over rich data domains and quantitative operators for statistical analysis as the fundamental structure that partitions the broad concept of hyperproperties into specific property classes each particular class is then supported by algorithms that provide a uniform solution for all the properties within the class the project will bring the analysis of hyperproperties to the level of traditional notions of safety and reliability and provide a rigorous foundation for the debate about standards for privacy fairness and explainability that future softwarebased systems will be measured against
|
optimizing passenger experience in public transport
|
the current global climate crisis and ongoing shift towards autonomous transport necessitate sustainable and passengercentric public transport solutions the goal of optipex is to enhance of sense of comfort and safety of the passengers as well as the security and ease of travelling by cocreating ethical and passengeraware public transport services together with specific target user groups such as wheelchair users passengers with large objects fragile passengers with limited mobility tourists and students to achieve this optipex is built on three fundamental development pillars measurement analytics and interaction optipex partners will develop perception technologies to measure passenger behaviour and situations trustworthy analytics is essential in recognising realtime passenger experiences and situations enabling interaction with services and vehicles moreover optipex partners will develop adaptive and interactive vehicle technologies and digital services in collaboration with target groups and suitable for various public transport modes these services will optimise the onboard experience promoting safety inclusiveness and trust ultimately improved passenger satisfaction will drive the adoption of automated public transport technologies and improve the sustainability of mobility services via contribution to the modal shifta consortium consisting of 3 research organisations 6 industry members and 2 smes will validate the developed solutions together with target groups and other stakeholders in three living labs the consortium has leading expertise in human behaviour usercentric design vehicle technologies modelling and data analysis and adaptive and interactive services the successful adoption of optipex results will be facilitated by efficient dissemination communication and exploitation activities in collaboration with the connected cooperative and automated mobility ccam partnership
|
rephase redox regulation of phase separation for plant adaptation to stressful environments
|
the proposed project explores the intriguing possibility of reactive oxygen species ros regulating the formation of stress granules sgs during heat stress heat stress triggers the rapid accumulation of ros with h2o2 playing a pivotal role as a signalling molecule that induces oxidative posttranslational modifications oxiptms to regulate protein activities on the other hand an increase in temperature leads to the formation of enigmatic droplets in the cytosol known as sgs these membraneless organelles mlos arise through liquidliquid phase separation llps enabling the concentration of proteins mrna and metabolites to facilitate cellular adaptation ros accumulation and sgs formation have traditionally been viewed as independent events in the heat stress response however recent studies have shed light on the significance of oxiptms as regulators of protein llps in plantsmoreover my preliminary experiments have demonstrated that the chemical blocking of oxiptms impairs sg formation during heat stress i propose that ros accumulation during heat stress induces oxiptms on proteins promoting llps and facilitating sg formation the rephase project aims to address this hypothesis through two main objectives firstly i will investigate the dynamics of the redox state within sgs during heat stress secondly i will map the landscape of oxiptms in sgs shedding light on their distribution and functional implications to achieve these goals the fluorescent redox biosensor rogfp2orp1 and the proteomic oxitrap probe yap1 will be targeted to sgs utilizing these innovative methods will enable a comprehensive exploration of the redox biology of sgs leveraging the stateoftheart proteomic core and live cell imaging facilities available at the host institute by bridging the gap between redox signalling and sgs the rephase project promises to provide valuable insights into the mechanisms underlying plant adaptation to environmental stress
|
senolytics repurposing in childhood refractory epilepsies
|
epilepsy is a frequent neurological disorder characterized by recurrent seizures resulting from hyperexcitability and hypersynchrony of neuronal networks cortical malformations including focal cortical dysplasia fcd are rare sporadic diseases that cause earlylife drugresistant seizures for which surgery is the only therapeutic option to control seizures surgical inaccessibility and failures are significant clinical drawbacks this emphasizes a critical and urgent need for new precisionbased therapies for this debilitating childhood disorder in recent years my team contributed to revealing that fcd are caused by brain somatic mutations in genes belonging to the mtor pathway a signaling cascade regulating key physiological cell functions such as growth proliferation and metabolism during the course of my ercfunded project we discovered specific biomarkers in both human and mouse preclinical fcd brain tissues in episen we propose an innovative pharmacological strategy based on the selective elimination of mutated cells by repurposing available molecules that are currently used in clinical trials in other diseases for fcdrelated epilepsy we hypothesize that abnormal cells once acutely cleared will offer a prolonged benefit on seizures direct users include applied research groups pharma companies the medical community for clinical trials and patient associations
|
impurities in the microstructure of eemian greenlandic ice via laser ablation
|
deep ice cores from ice sheets are unique climate archives chemical impurities deposited initially on the ice sheets are used to reconstruct the climate of the past despite being investigated for several decades the processes affecting impurities after their deposition ie in the microstructure of ice still need to be clarified especially in the oldest parts of the cores while the quest for the oldest ice in antarctica has just started many open questions remain before analysing ice up to 15 myr old the mesmerise project aims at investigating the oldest sections of the ngrip neem and recap ice cores from greenland which reach back to the last interglacial the eemian and thus enable important insights into the conditions of a warmer world in ngrip ice annual layers and impurities seem unaffected by relocation diffusion and deformational processes mesmerise will test this hypothesis by comparing chemical impurities in holocene and eemian ice using two stateoftheart laser ablation inductively coupled plasma mass spectrometry laicpms 2d imaging systems the recent refinement of the laicpms technique by assist prof pascal bohleber at the university of venice enables the analysis of impurities in ice in ultrahigh resolution and two dimensions it is thus the most promising tool to distinguish annual layers and the localisation of different chemical elements in the microstructure of deep polar ice to investigate postdepositional processes affecting the climate signal assist prof bohleber and assoc prof anders svensson an ice core analysis expert from the center for physics of ice climate and earth at the university of copenhagen denmark guarantee highquality research and education at the host institutions mesmerise will further build a bridge between the two erc projects aice and green2ice and thus benefits from possibilities such as applying machine learning and modelling to experimental and observational data
|
opera fandom in the digital age
|
today interactions between audiences and theatres occur to a significant extent via online platforms and digital media opanda studies the impact of these transformative technologies on opera fandom although recent research has addressed the digital dissemination of opera the phenomenon of cyberfandom remains underresearched situated at the intersection of musicology sociology and media studies the project asks how opera fans perform their passion digitally this entails the investigation of their interactions on the web but the project also considers how cyberfandom intersects with traditional fan behaviour in a postpandemic and hypermediatised society in which the divide between stage and screen is constantly blurred the project reconsiders past audience practices and envisions possible future onesopanda aims at providing a pioneering study of todays opera fans ie the most active operagoers including their digital practices and communities to reach this goal opanda is based on a comparative and qualitative analysis of representative case studies combining digital ethnography on web communities and fanzines participant observation at opera companies la scala paris opera the new york metropolitan opera and interviews with fans dr nicol palazzetti researcher is well placed to carry out this research thanks to an outstanding background in musicology and sociology and a solid expertise in performing ethnography among opera fans by situating his project at sapienza university of rome he advances his career in new directions he has the key opportunity to work with prof emanuele senici supervisor a prominent opera scholar specialising in opera and media and with prof romana and cosupervisor an expert in fan studies a trainingbased secondment at the digital ethnography research centre in melbourne and a disseminationbased secondment at the music department of yale university support the achievement of the project
|
oxygen optimization therapy through bcpap for management of childhood pneumonia in general hospitals of lmics
|
pneumonia is a leading cause of morbidity and mortality especially among children in subsaharan africa nigeria and ethiopia are among the 5 countries that account for half of the underfive pneumonia deaths majority of the deaths from pneumonia are however preventable with early diagnosis and appropriate management in children with pneumonia hypoxemia is quite common and constitutes a major risk factor for death the who and other leading child health agencies urge widespread access to oxygen therapy bubble continuous positive airway pressure bcpap is a method of delivering oxygen and positive pressure into the airways thus keeping the alveoli open for improved gas exchange while use of bcpap devices appears safe and effective worldwide scaling of quality bcpap devices in low and middleincome countries lmics has been limited this has prevented most children in lmics from receiving lifesaving noninvasive respiratory support which could have saved many lives achieving sustainable development goal sdg 32 of the reduction of under5 mortality to at least as low as 25 per 1000 live births by 2030 will likely not be possible without access to innovative and low cost interventions devices such as bcpap in lmics the aim of the optbcpap is to perform contextappropriate scaleup of bcpap in settings of very high disease burden nigeria ethiopia and malawi using the the positive results and the lessons learned from clinical trials conducted in ethiopia bangladesh and ghana in addition to scaling up bcpap we will deeply explore additional factors associated with treatment failure and mortality from severe pneumonia we aim to generate data on adherence to treatment guidelines healthcareseeking behaviour magnitude of respiratory syncytial virus infection antimicrobial resistance pkpd of commonly used antibiotics and generate novel recommendations for antibiotic treatments tailored to the populations in these diverse settings
|
understanding the interaction of t cells and immune complexes in systemic lupus erythematosus
|
systemic lupus erythematosus sle is an autoimmune disease with a complex pathogenesis immune complexes ics are formed and deposited in various tissues leading to inflammation and damage t cells are part of the adaptive immune system but also express innatelike receptors that could interact with ics by binding complement factors or the constant region of immunoglobulins however the extent of these interactions and there relevance for the sle pathogenesis has not been investigated so far in the ticisle project we will analyze these interactions by 1 investigating the expression of receptors that could interact with ics on t cells in the blood and inflamed tissue of sle patients 2 cultivating t cells with immune complexes and antibodies stimulating or blocking individual receptors thereby elucidating the consequences of these interactions and 3 analyzing spatial t cellic interactions and their secondary consequences like proinflammatory changes in stromal cells and chemoattraction of inflammatory cells in skin samples from sle patients we hypothesize that t cellic interactions result in costimulation of t cells leading to production of proinflammatory cytokines cytotoxicity and induction of an inflammatory microenviornment understanding these interactions can then be exploited by the future development of therapeutics targeting these interactions an additional focus of the project will be the personal development of the applicant and the dissemination and exploitation of project results
|
dissecting the impact of epithelial stem cell niches on oral cancer heterogeneity
|
the oral epithelium is a unique tissue with a high degree of structural heterogeneity and distinct microenvironments niches however the molecular mechanisms underlying the sitespecific proliferation and differentiation of oral epithelial stem cells oescs remain poorly understood oral squamous cell carcinoma oscc one of the most common oral cancers is a heterogeneous cancer type occurrences of metastatic lesions and treatment response differ from oral site to site indicating a causal link to the heterogeneous nature of distinct oesc pools in the oralniche project we will for the first time systematically and comprehensively characterise the oesc pools dissect key mechanisms underlying oral epithelial sitespecificity and define their contribution to oscc heterogeneity to achieve this we will combine novel mouse models and patient material with cuttingedge methodology including whole mount imaging singlecell sequencing and organoids initially we will profile the proliferative activities of oescs and explore how stemness is regulated within defined niches in homeostasis oscc and chemotherapyinduced mucositis subsequently we will functionally assess cellular cues that modulate stemness in the oral epithelia and generate a comprehensive singlecell atlas of oescs and their cellular niches lastly using oscc patient material we will validate key observations to define potential new biomarkers and therapeutic targets in summary this multidisciplinary approach will reveal how the distinct oesc pools maintain homeostasis and how they respond to challenges such as mucositis and oscc oralniche will deliver new knowledge on the impact of tissue sitespecificity on tumour heterogeneity and therapy response which will have significant implications for oscc patients moreover the knowledge gained and the technological advances proposed will be applicable to other tissues and tumour types and thus provide a model approach in cancer research
|
secure hardware with advanced nonvolatile memories
|
over the recent years the explosive growth of digital technologies allowed to implement disruptive business models driven by data collection and processing in particular the internet of things iot opens unprecedented opportunities for consumers smart society organisationscompanies industry 40 smart factories and governments smart nations however as every adoption of new technologies involves some risks security attacks are amongst the most severe challenges for iot only in 2021 the inflicted damages have been valued 6 trillion globally and 1097 organizations were hit by ransomware attacks secure iot is generally enabled by the physical unclonable function puf namely a hardware function which is embedded in the chip and capable of generating a random unique response to a given challenge improvements in attack methods over the years have recently moved the field of pufs from the conventional siliconbased cmos technology toward emerging nonvolatile memories nvms the latter allows for high density low cost highly scalable puf with the capability of reconfiguration currently a truly tamperresistant and reliable weak puf leveraging stochastic switching of nvms for secure iot is still missing and highly requested by the market within the erccog project rescue 20152020 a novel method for true random number generation trng based on nvms was developed and patented the trng scheme allows for ipuf invisible puf namely a digital highly reliable puf which is 100 robust to physical attacks within the shannon project we will address the technical and commercial feasibility of ipuf validating the concept with industry grade embedded nvms and elevating its technology readiness level via experimental tests and simulations new architecture and algorithms will be developed to strengthen the ip position of ipuf as a scalable security primitive for iot systems
|
a paneuropean network of genderconscious investors to support femaleled companies for growth and sustainability
|
european innovation performance continues to increase yet inequalities particularly in access to investment are still noteworthy there is a need to close the performance gaps which are still visible between strong innovators north and west eu and moderate and emerging innovators south and east eu mostly a major asset to successful and sustainable business growth relies upon awareness and strong communication between innovative sectors and investors on available resources their access and interventions by publicprivate funders improving networking between innovation ecosystems is key to the success of growing businesses and driving continued economic developmenther funds ambition is to foster knowledgesharing and synergies between innovation actors existing initiativesprojects in order to support the next generation of startups with an emphasis on womenled companies and genderconscious investors these interactions will notably lead to best practices identification capacitybuilding activities and guidelines strengthening and broadening an interregional collaboration hub will promote a more competitive eu and a more sustainable inclusive diverse and resilient worldthis will be done in a communitydriven crossfunctional crosssectoral multiplier based way with partners bringing together communities of experts from different deeptech sectors from around europe and beyond her fund will 1 transform less connected territories into recognized and attractive innovation valleys that pool and reward investments 2 create bridges between eu innovation ecosystems increasing access to capital and investment in less connected innovation ecosystems and allowing local startups benefiting from foreign investments 3 raise the number of gender conscious investors in europe for support to womenled companies 4 boost women entrepreneurship especially in moderate and emerging innovators offering them access to more funding opportunities
|
sectorcoupling hub for circular use of thermal and industrial waste
|
within hurricane a sectorcoupling circular hub centered around the arcelormittal ghent site will be created we will target efficient resource management together with the recovery and utilization of squandered industrial waste heat and water together with arcelormittal ghents ongoing initiatives this will lead to a reduction of energy water and raw materials by at least 20thanks to the ongoing projects taking place within and around the ghent site the site is already well connected to many other industries like waste suppliers chemical producers ethanol offtake h2 waste gas renewable power producers and wastewater treatment it has become a multisectoral hub leading to efficient implementation of industrial symbiosis concepts the ghent site has a significant amount of recyclable energy material and water that allows this symbiosis these aspects are not only from the steel making processes but also from other operations taking place in the mentioned multisectoral hub this hub can be further enhanced with the integration of waste heat with its ongoing initiativesour solution aims at developing and demonstrating novel heat recovery heat exchanger and upgrading heat pumps solutions from selected operations and then coupling it with the internal and external off takers by means of a heat grid with digital tools aspects like broadening the district heating network and adapting the heat demand profile of the buildings to better match the intermittent of the waste heat can be optimized finally an integrated software tool for circular hubs that combines the different tools and data produced at the different operations will be developed and validated through two virtual demonstrations and a circular hubs blueprint the replication potential will be proven the consortium is formed by 12 partners from 5 different countries including 4 research organizations 1 large end user 3 smes and 3 civil organizations and 1 linked 3rd party
|
selffoldable origamiarchitected metamaterials
|
technological progress and increasingly environmentalrelated problems call for new cuttingedge design strategies to improve materials functionalities the sfoams challenge is to breakthrough metamaterial design by implanting origamikirigami capabilities within architected cellular structures at different scales thus bringing metamaterials to unprecedented mechanical performance the resulting metamaterials will combine multistability anisotropy geometrical frustration control of localized deformation and ellipticity loss to achieve a new capability selffoldability and shapemorphing induced by external stimuli unlike what happens in currently available origami the location of the creases is not a priori imposed but selfguided by ellipticity loss occurring in the homogenized material equivalent to the kirigamiorigami and selfcontrolled by embedding within the microstructure topological point and line defects this introduces an unexplored field of research in which a material element will become able to mechanically react to actions from the surroundings through a direct change in its shape thus reaching a configuration that optimizes its stiffness strength toughness and in a word its environmental resilience the research project sfoam will develop modelling based on the mechanics of solids and structures numerical simulations and experimental tools for the optimal design of origamikirigamilattice metamaterials applications are envisaged in soft robotics where grippers grasp and manipulate objects without damaging them and in wearable devices where materials gently adapt to humans movements moreover the design principle provided by sfoam is of great interest in developing adaptive medical devices and in maximizing solar power intake through flexible pvs integrated into metamaterials capable of changing shape depending on the sun motion
|
modelling religiopolitics the imperium christianum via its commoners
|
from the 10th c onwards new polities emerged on the periphery of the holy roman empire hre the new centre of christendom endowing christianity as an institutional system was integral to the emperors power expanding his influence and securing his rule in the new kingdoms previous narratives have been generally constructed on the basis of limited written accounts which mainly concern the higher echelons of society emphasising the role of secular and ecclesiastical elites however the ecclesiastical and secular administrative organisation of the rural population could not be reconstructed satisfactorily from these sources despite their importance for the stability of both state and churchrelic proposes a complex comparative analysis and contextualisation of archaeological and historical remains of the rural population living on the eastern fringes of the hre during the ottonian and salian periods 10th 12th c exploring the influences of centres and networks of secular and ecclesiastical lords of the natural environment and of the economic infrastructure investigating this oftenoverlooked segment of the population its hitherto unexplored or neglected role allows us to study how toplevel changes in political and ecclesiastical organisations can be reflected in the evidence concerning the lower levels of society and of the local church network how different strategies worked in different political settings and what role local initiativesagencies could have played in religious and political shifts the religiopolitics of the hre is a wellresearched topic still investigating the involvement of the rural population in these processes is a new approach and so is the applied methodology and primary data proximity network and catchment analysis on archival archaeological data and historical evidence individually such evidence provides little information but together it forms a significant and unexplored dataset of the rural population
|
ultrasensitive fieldresolved infrared spectroscopy for early disease detection
|
early detection is one of the most effective ways to improve the survival rate for diseases like cancer however current diagnoses often rely on invasive procedures and specialized tests posing challenges for regular monitoringfieldresolved infrared spectroscopy which probes the molecular fingerprint of human blood has achieved remarkable detection sensitivity by combining ultrafast laser technology with electricfield infrared detection despite its potential the technique has yet to meet the stringent requirements of early screening including single nanogram per millilitre sensitivity 1012 dynamic range and longterm stabilitythe proposed project ultrasensitive fieldresolved infrared spectroscopy for early disease detection aims to overcome these challenges by developing a groundbreaking instrument for fieldresolved infrared fingerprinting of human blood plasma samples and demonstrate its performance for health monitoring in particular the researcher intends to develop i a multikhz delay scanning system based on two crzns lasers synchronized down to singlefemtosecond timing precision which aims to record measurements faster than most laser noise contributions ii superoctavespanning fieldresolved infrared detection with a dynamic range exceeding 1012 and iii an ultrarapid referencing scheme that simultaneously records reference infrared electric fields with the measurement to realize standardization of the infrared molecular fingerprints and the longterm reproducibilityby addressing these limitations the project will achieve unprecedented levels of sensitivity dynamic range and stability it provides an avenue for analyzing serum and plasma samples across a wide range of individuals and time frames potentially uncovering spectral markers for different diseases the system will be a minimally invasive and costeffective method of early disease detection to improve patient prognosis and overall healthcare outcomes
|
training a new generation of researchers in offshore seaweed aquaculture to produce highvalue chemicals
|
seachem will provide highlevel rd training for earlystage researchers in the emerging field of marine biomass production by addressing hot issues in offshore seaweed cultivation and its application as a source of renewables seachem will take away current hurdles for its wide adoption in the eu concurrently the interdisciplinary seachem network composed of academia industry and sector organisations and the variety of scientific disciplines integrated into the seachem rd scheme guarantees a multidisciplinary formation of the 10 nextgeneration highlytrained doctoral candidates the main seachem rd objectives are indeed spread over construction engineering development of stainless steel offshore structures biology optimal conditions for seaweed cultivation and chemical engineering intensified extraction of valuable compounds by the combination of stateoftheart research topics with multiple transferrable and social skills training events seachem will ensure the broad scientific and personal development of the doctoral candidates the high societal and economic relevance of this field is supported by the ever increasing societal pressure for the development of renewable resources also relieving the dependency of the eu on imported fossil raw materials the growing worldwide market in renewable and sustainable products is driving this economic sector and is already creating a large need of highlyskilled professionals hence ensuring a myriad of job opportunities for the doctoral candidates
|
taming radiative heat emission with anisotropic and timevarying media
|
thermal emission is a fundamental and ubiquitous process of energy and entropy transport impacting science and engineering in various way yet its stochastic nature expressed in a broadband spectrum lack of polarization and directionality severely limits its control and manipulationtreat aims at introducing a novel method for engineering the radiative heat transport and achieving unprecedented dynamical control over the spectrum and the momentum of thermal radiation to achieve this goal i propose to combine two classes of emergent materials timevarying epsilonnear zero enz media and hyperbolic materials hms the time modulation of enz media will allow to overcome the fundamental limits to thermal emission set by the plancks and stefanboltzmanns laws and achieve active control over its properties while the hms will enable to extract and guide the intense thermal radiation confined at the emitter surface ie in its nearfieldtreat objectives address three intriguing questions i can we create a timevarying media with ad hoc time modulation ii can we manipulate thermal emission beyond the plancks law using the timemodulation iii can we improve our control of the radiative heat flow in the nearfield answering these questions requires the combination of expertise in nanophotonics and ultrafast science and perfectly suits my scientific profile treat specifically targets the thermal emission engineering in the transparency window of earth atmosphere relevant for radiative cooling and the development of novel coherent thermal sources in the thz range treat will provide a fundamental advance to our understanding of thermal fields beyond fluctuational electrodynamics and a novel method for engineering the radiative heat flux anticipating significant impacts in several applications of thermal light that would benefit from the active control of its properties such as radiative cooling energy harvesting and optoelectronics
|
data monetization interoperability trading exchange
|
datamite empowers european companies by delivering a modular opensource and multidomain framework to improve data monetizing interoperability trading and exchange in the form of software modules training and business materials datamite unleashes the monetization potential at two levels at internal level users will have tools to improve quality management of their data the adherence to fair principles and will be able to upskill on technical and business aspects thanks to the multiple opensource training materials the project will generate therefore data will become trustable and more reliable also in other paradigms like ai at external level keeping users in control of their data will provide new sources of revenue and interaction with other stakeholders the architecture envisioned for datamite enables dihs sandboxing becoming a potential instructor on their onboarding of smes and lowtech smes into the data economy together datamites solutions will function as a catalyst to boost data monetization in the european productive fabricdatamite will validate the results in 3 different use cases with a total of 6 pilots demonstrating that the framework is interoperable and usable in different domains and user needs as 1 intracorporate multidomain data exchange 2 data trading among data spaces 3 integration with other initiatives as data markets eu aiondemand platform or dihs sectors covered by the pilots are agriculture energy industrial and manufacturing and climateto achieve this the project relies on a consortium of 27 partners from 13 countries bringing together key actors of the data value chain data spaces technical and business stakeholders multiple key communities idsa gaiax euhubs4data ai4europe eosc key experts in legal and ssh aspects to guarantee legal and societal compliance and facilitators on opensource community building and standardisation activities to accelerate the transfer to the market
|
communities and artistic participation in hybrid environment
|
the aim of the project is to investigate and perform the possibility of elaboration of an enhanced model of interaction and somatic participation between artists and communities coming from different cultural backgrounds both traditional and virtual ones in hybrid environment including physical and virtual layers by this mean we will develop the concept of vr participation building the integrated framework for vrmediated consensus and community in a form of an aesthetic dialogue geared toward layering and investigating aesthetic experiences through vr technology the projects physical mobilities will be directed towards sharing knowledge and proficiency in different fields such as humanities arts technology and education focused on the research on communities arts and participation in contemporary digital time in countries involved in the project poland portugal italy greece and kenya apart of activities realized during the mobilities workshops trainings field research and interviews the cooperation between partners in the caphe project will be continued during the whole project in the virtual space online this will be realized with use of modes of telepresence augmented reality ar and virtual reality vr technologies such as the altspacevr platform the projects team will be engaged and will operate in experimental hybrid environment to stimulate and research the process of socialartistic interaction our process will engage artists communities and researchers from six countries and on two continents europe and africa the countries are located on the south of europe portugal italy and greece and north and south from this line poland and kenya this gives a broad spectrum of contexts
|
spcoordinated transition metal single sitesdoped carbon matrices as electrocatalysts for nitrogen reduction
|
the electrochemical nitrogen reduction reaction nrr provides a sustainable alternative to the haberbosch process for ammonia nh3 production transition metal catalysts have poor nrr performance due to the highly competitive hydrogen evolution reaction and the scaling relation between inert dinitrogen n2 and other reaction intermediates singleatom catalysts sacs have been proven to be effective in overcoming these limitations owing to the enhanced active sites and the anomalous quantum size effect inspired by biological rhizobia nitrogen fixation this proposal green renewable energyderived electrocatalytic nitrogen reduction reaction that yields nh3 under mild conditions green aims to develop characterize and mechanistically understand spcoordinated transition metal single sitesdoped fe mo and femo carbon matrices mscms as electrocatalysts for high activity and selectivity nrr the specific goals of green are i successfully synthesis of mscms electrocatalysts to achieve high performance and selectivity towards nrr ii characterize mscms to determine their electronic structure local atomic environment charge density and affinity with n2 molecules etc iii determine the activity of the mscms catalysts and finetuning of working conditions and parameters for highly efficient electrocatalytic nrr and the catalytic mechanisms for nrr will be further recognized the results of this project have the potential to greatly reduce the energy consuming and co2 emissions due to the ambient operating conditions and using water as the hydrogen source which aligns with both the european green deals call for green energy and zero net emissions of greenhouse gases by 2050 and united nations sustainable development goals throughout this project the applicant will learn new techniques develop her skills as an independent researcher and mentor and expand her international collaborations and relationships network
|
engineering phosphate solubilization microorganisms and deciphering the mechanism of phosphate solubilization during plantmicrobe interactions
|
phosphorus p is one of the major essential macronutrients required for plant growth and food production crop yield on 4060 of the worlds arable land is limited by p availability however due to the high fixation capacity of soil and inactivation of the applied phosphorus in soil immobilization and precipitation results in scarcity of available phosphorus to plants using phosphate solubilizing microorganisms psm to promote plant growth can be a promising strategy for sustainable food production in the future however many studies have indicated that the mechanisms seen in vitro do not translate into improved crop p nutrition in complex soilplant systems there are still some challenging questions needed to be answered before using psms as effective biofertilizers in soil conditions stateoftheart approaches like the highthroughput screening method and metagenomic analysis should be encouraged to facilitate the psms application this project aims at identifying and engineering phosphate solubilizing microorganisms and deciphering the mechanism of phosphate solubilization during plantmicrobe interactions for example 1 use a highthroughput method to identify psms 2 screen more than 3000 bacterial strains and 400 fungal strains to decipher their taxonomy evolutionary relationships and investigate the specificity of psms in solubilizing different insoluble phosphates 3 use mutant libraries screen and metagenomic analysis to explore the phosphate solubilizing mechanisms 4 investigate how plant root exudates influence microbiome assembly in plimiting conditions 5 optimize synthetic phosphatesolubilizing communities to promote plant growth arabidopsis thaliana lotus japonicas and food production glycine max in plimiting soil the outcome of this project will provide new insight into nutrientmediated regulation of plantmicrobe interactions and facilitates the development of biofertilizers in the field of nutrient supply
|
entanglementassisted thermoelectric transport in quantum systems
|
in the proposed project entanglementassisted thermoelectric transport in quantum systems eatts the european researcher dr nahual sobrino together with prof rosario fazio at the international centre for theoretical physics ictp will collaborate with international research groups to unveil innovative thermoelectric properties that hold transformative potential for sustainable energy technologies quantum information science and the development of advanced quantum materials the projects objectives will concentrate on the exploration of thermoelectric phenomena mediated by entangled electrons across a variety of quantum systems a comprehensive theoretical and computational framework will be established to explore and enhance thermoelectric performance in systems where electron entanglement plays a pivotal role cuttingedge calculations will be performed using sophisticated theoretical frameworks including quantum master equations qme hierarchical equation of motion heom and quantum information techniques this will guide to elucidate the intricate relationship between entanglement systemenvironment interactions and thermoelectric performance in double quantum dots dqd and cooper pair splitters cps systems moreover the project aims to extend the scope of density functional theory dft to access to entanglement measures in transport scenarios through the development of extensions of iqdft this will facilitate a more efficient computational description of thermoelectric phenomena under the influence of entangled electrons additionally the thermoelectric and entanglement characteristics of multiple diatomic molecules will be investigated by mapping the system into effective hamiltonian models the computational framework developed will advance our understanding and serve as a guide for experimental endeavors by selecting promising materials and parameter regimes
|
promoting codesigned sustainable health interventions with young changemakers for reduced risk of noncommunicable diseases ncds in urban burkina faso kenya and tanzania
|
changemaker objective to implement evaluate a sustainable health intervention program on health nutrition environmental outcomes for the primary prevention of adolescent obesity related noncommunicable diseases ncds together with adolescents in three rapidly urbanizing cities in burkina faso kenya tanzania background there is an increasing epidemic of adolescent obesity that can contribute to adult obesity morbidity ncds in a broader sense sustainable health interventions in urban low and middleincome countries are critical in addressing lifestyle factors that contribute to obesity diabetes hypertension in later life such as unhealthy dietary habits inactivity sedentary behaviors while shaping urban environments considering obesity is a complex issue that is influenced by wide range of interconnected factors such as policy environment social economic cultural behavioral commercial biological determinants a wholesystems approach that converges multiple sectors ie health education environment and agriculture and stakeholders ie adolescents caregivers staff local government communities policymakers implementers are needed for obesity prevention in lmics our strategy four evidencebased strategies which will be adapted to context through a codesign process 1 urban farming in schools with satellite farms and organic waste composting 2 sustainable health modules for classrooms 3 linking to healthcare workers through health talks using motivational interviewing techniques and 4 who best buys mass media campaign our evaluation 3 clusterrcts in secondary schools within the framework of urban health demographic surveillance systems implementation process evaluation costeffective evaluation our expected results evidence of how to implement and scale a sustainable health intervention estimate a mean difference in bmi of 0175 which could lead to reduction of 5 in the prevalence of obesity
|
the ecophysiology of sleep under global change
|
sleep is ubiquitous in the animal kingdom and serves essential biological functions yet sleep incurs substantial costs in terms of increased vulnerability to predators and reduced time for acquiring resources how sleep is regulated by ecological factors eg predation and expressed in the natural world is highly understudied more so in nonmodel taxa of reptiles and amphibians further sleep can be comparatively and mechanistically understood through the lens of environmental change processes such as biological invasion and urbanization in this study we propose to examine the degree of lability in sleep trait expression of reptiles and amphibians under environmental change and how adaptive these responses are we will employ a comprehensive suite of electrophysiological and behavioural measures of sleep and quantify responses to i increased exploration during rapid population expansion of early stage biological invasion ii reduced predationrisk during biological invasion iii novel stressor of night light due to urbanization the project will break new grounds in terms of quantification of sleep in nonmodel taxa using stateoftheart technology alongside behavioural measures application of an ecoevolutionary framework to sleep research and understanding the role of global change processes in shaping sleep in the animal kingdom thereby generating insights into the regulation and expression of sleep in the natural world through the project the researcher will learn neurophysiological techniques of sleep quantification from the host and use novel technology developed by the collaborator the hosts distinguished academic record domain expertise in sleep electrophysiology of reptiles and amphibians and large research network make him uniquely qualified to transfer expertise to the researcher and help him build an interdisciplinary skillset and become an innovative academic in the field of sleep ecophysiology research
|
digital process chain for energy renovations using prefabrication
|
the digifab consortium will develop a renovation process consisting of 1 digital process chain with detailed assessment and cocreation methodology to cover the entire renovation workflow 2 choice of adaptable prefabricated modules with passive and active technologies to achieve near zero energy building nzeb levels and reduced environmental impact 3 assessment and monitoring software with building information modelling bim to automate the process estimated installation time is 2 days per unit of 200m2 surface with 30 less cost than conventional renovationour solution transforms the renovation process by digitizing it from design brief to finalization the approach not widely adopted in the sector offers significant cost and time reduction by accurately collecting and centralizing data at all stages minimizing uncertainties that cause delays and increase costs cocreation with occupants gathers expectations and best renovation times building data is collected with accurate methods transformed into a highquality digital twin that automates energy and structural analysis leading to design optimization with the best technology combinations according to project inputs results from the analysis are used directly to manufacture the prefabricated modules using modern methods of construction mmc and just in time jit the modules use novel lightweight concrete mixes with recycled materials biobased materials active envelope heating technologies energy generation and management including ventilation installation follows specific site conditions monitored through procedures such as laser scanning a worksite solution is used to manage and monitor levels of construction demolition waste and noise at the end of the commissioning process energy performance documentation is provided three demonstration sites in spain austria and greece with diverse building typologies will showcase how the digifab solution benefits stakeholders
|
light elements in irons and metalrich meteorites their isotopic distribution and evolution in the protoplanetary disk
|
knowledge of the light element h c n characteristics of planetary building blocks is key to our understanding of the development of habitable conditions on earth since magmatic iron meteorites originate from the metallic cores of the earliest differentiated planetesimals they may preserve a record of h c and n isotopic variations in the inner and outer solar system during the first stages of planetary accretion based on novel multilightelement isotopic analyses of irons and other feni alloyrich meteorites and experimental simulations project ironis aims to answer the fundamental questions of i how the distributions of h c and n and their carrier phases evolved in space and time within the earliest stages of the protoplanetary disk and ii how h c and n were distributed between metals and silicates during planetesimal accretion differentiation and subsequent evolution a major objective is to develop novel secondary ion mass spectrometry protocols for analyzing h c and n in situ in feni alloy and to combine these with bulk nnoble gas analyses by static noble gas mass spectrometry the originality and uniqueness of project ironis thus lies in the coupling of two stateof theart analytical techniques which allow the quantification of any solar gas and cosmogenic nuclide contributions only once the effects of these secondary components are understood can spatiotemporal isotopic variations in the protoplanetary disk be investigated in parallel new crosscalibrated n analyses of experimental run products will provide constraints on the degree of n isotopic fractionation during alloysilicate partitioning and will permit us to assess if the n isotopic compositions of irons represent a primary feature of their parent bodies ultimately by investigating the remnants of the first planetesimal populations project ironis will provide new fundamental insights into the cosmochemical history and evolution of lifeforming light elements
|
integrable manybody systems through the mathematical lens
|
the project focuses on the relation between integrable manybody systems and three important fields of mathematics partial differential equations painlev equations and probability theory the goal is to build new connections in this context by considering recent results as follows the first objective consists in explaining how a class of integrable manybody systems that appeared over the last 5 years can be used to parametrise specific solutions to hierarchies of partial differential equations an algebraic and a geometric interpretation of these parametrisations will be sought the second objective deals with the extension of the hamiltonian formulation of manyparticle painlev equations called the calogeropainlev correspondence to new cases this investigation will make a central use of the current activity on discrete painlev equations and the quantum analogues of painlev equations the third objective related to probability theory is twofold on the one hand quantum versions of integrable manybody systems will be derived by adding noise to specific diffusion processes that are constructed using their classical versions on the other hand important properties of probability distributions appearing in random matrix theory or the study of beta ensembles will be obtained the point of view will be to interpret these distributions in terms of suitable manybody systems whose integrability will play a key role for the computation of the desired properties
|
post quantum cryptography framework for energy aware contexts
|
in the last three decades public key cryptography has become an indispensable component of global communication digital infrastructure these networks support a plethora of applications that are important to our economy our security and our way of life such as mobile phones internet commerce social networks and cloud computing in such a connected world the ability of individuals businesses and governments to communicate securely is of the utmost importance at the moment the quantum threat is theoretical as quantum computers that fulfill the requirements of shors and grovers algorithms for long keys are not available but it is evident that widely used rsa ecdsa ecdh and dsa cryptosystems will need to be replaced by postquantum cryptography pqc the need for addressing this problem early enough has been recognized by various relevant organizations and the national institute of standards and technology nist has started an effort to identify cryptographic algorithms able to withstand quantum computer attacks by 2022 and make them available by 2024 the main objective of pqreact project is to design develop and validate a framework for a faster and smoother transition from classical to postquantum cryptography for a wide variety of contexts and usage domains while leveraging europes most powerful quantum infrastructure ibm quantum computer from fraunhofer fokus this framework will include pqc migration paths and cryptographic agility methods and will develop a portfolio of tools for validation of post quantum cryptographic systems that will allow users to switch to postquantum cryptography taking under consideration their individualities and various contexts and a wide variety of real world pilots ie smart grids 5g and ledgers the project will also foster a series of open calls for smes and other stakeholders to bring and test their pqc algorithms and external pilots on the pqreact quantum computing infrastructure
|
beyond bones integrating statistics and machine learning tools into archaeological evidence to decode neanderthalcarnivore scenarios
|
the relationship between humans and their natural environment has significantly shaped our evolutionary history carnivores in particular our main competitors in many past ecosystems likely had a profound impact on hominin behaviours neanderthals potentially more carnivorous than other hominin species present an intriguing focus were the relationships between neanderthals and carnivores primarily rooted in rivalry mutual avoidance or subtle survival adaptations how did they impact neanderthal niche exploitation can changes in these interactions shed light on neanderthal disappearance archaeological sites yield thousands of animal bone fragments with traces of neanderthal and carnivore consumption that offer valuable insights into this coexistence yet these data remain underexploited due to the challenges derived from interpreting complex mixed taphonomic processes the bites project aims to reconstruct neanderthalcarnivore interactions using targeted quantitative methodologies which are tailored to detect patterns previously unattainable with traditional approaches employing both multivariate statistics and machine learning i will initially accurately quantify hominin and carnivore relative activities across four middle paleolithic sites in iberia set in different environments subsequently reusing literature data the project will build statistical and machine learning models to identify the main interaction type in previously studied sites including scavenging avoidance and competition for prey lastly the project will explore any environmental spatial or temporal shifts in these interactions and their potential correlation with settlement patterns and the eventual disappearance of neanderthals the findings derived from bridging cuttingedge methods with ancient data promise to reshape our perspective of neanderthal ecological behaviour and adaptive strategies introducing fresh integrative approaches in paleolithic research
|
new generation methods for numerical simulations
|
relevant partial differential equations pdes problems of the 21st century including those encountered in magnetohydrodynamics and geological flows involve severe difficulties linked to the presence of incomplete differential operators related to hilbert complexes nonlinear and hybriddimensional physical behaviors embeddedmoving interfaces the goal of the nemesis project is to lay the groundwork for a novel generation of numerical simulators tackling all of the above difficulties at once this will require the combination of skills and knowledge resulting from the synergy of the pis covering distinct and extremely technical fields of mathematics numerical analysis analysis of nonlinear pdes and scientific computing the research program is structured into four tightly interconnected clusters whose goals are the development of polytopal exterior calculus pec a general theory of discrete hilbert complexes on polytopal meshes the design of innovative strategies to boost efficiency embedded into a general abstract multilevel solvers convergence framework mscf the extension of the above tools to challenging nonlinear and hybriddimensional problems through discrete functional analysis dfa tools the demonstration through proofofconcept applications in magnetohydrodynamics eg nuclear reactor models or aluminum smelting and geological flows eg flows of gasliquid mixtures in underground reservoirs with fractures as occurring in co2 storage this project will bring key advances in numerical analysis through the introduction of entirely novel paradigms such as the pec and dfa and in scientific computing through mscf the novel mathematical tools developed in the project will break longstanding barriers in engineering and applied sciences and will be implemented in a practitioneroriented opensource library that will boost design and prediction capabilities in these fields
|
enhancing the conversion of power to ethylene through developing surface oriented catalysts
|
ethylene as a key building block in the chemical industry has large market demand currently the dominant production route is steam cracking of ethane which is a highly endothermic and carbon intensive process proton ceramic electrochemical cells pcecs can selectively remove hydrogen from the reaction system thus breaking the thermodynamic equilibrium limitation in this project the improved pcecs equipped with highperformance anodes catalysts will be used as environmentalfriendly efficient and reliable way to coproduce ethylene and hydrogen from ethane at low temperature 400550 c demonstrating ethane conversion not less than 50 and ethylene selectivity not less than 80 here we will combine hydrothermal synthesis and insitu grown nanoparticles from matrix crystal lattice to develop the nanocatalyst with the specific surface facet and metaoxide interface the research tasks will be distributed into 6 work packages wps in wp1 we will use hydrothermal synthesis to prepare nanocatalysts with specific surface orientation and insitu growth of metal nanoparticles from the predoped matrix crystal lattice to form a special anchored interface structure improving the stability and efficiency of the catalysts in wp2 we will integrate the welldefined catalysts into the halfcells with the bace07zr01y01yb01o3 anode backbone through infiltration in wp3 the ethane conversion and ethylene selectivity of the pcec will be characterized by gas chromatography supported with electrochemical characterizations in wp4 dft calculations in combination with surface characterization will be conducted to explore the reaction mechanism of ethane dehydrogenation at the anode in wp5 we will cooperate with other laboratories for discussion and advice in wp6 we will disseminate our results in time to expand the impact
|
insitu operando organic electrochemical transistors monitored by nondestructive spectroscopies for organic cmoslike neuromorphic circuits
|
ultraflexible conformable and implantable artificial intelligence organic electronic devices hold promise to revolutionize the realtime monitoring and treatment of chronic diseases such devices are based on organic electrochemical transistors oects exploiting polymeric mixed iontoelectron conductors pmiecs as active layers however the development of efficient and stable devices is hindered by limited knowledge about structureproperty relationships of pmiecsiconic combines macromolecular synthesis with in situ and operando nondestructive spectroscopic methods in an innovative way to investigate with unprecedented accuracy iontoelectron transduction in oects from the molecular to the micrometre scale this provides the key knowledge to make a technological leap in development of smart therapeutic devicesas a proof of concept iconic develops an intelligent closedloop device for drugdelivery activation in a longterm vision healthcare devices will enable signal recognition with bodyfriendly electronics and administer medication without the risk of human erroriconic is a multidisciplinary highriskhighgain project engaging 8 partners from 6 countries covering the academic and industrial worlds including 1 sme the implementation is facilitated through 4 work packages 3 technical the complementary scientific skills brought in by the partners and stakeholders maximizes iconics impact
|
synthetic cells for functional food platforms
|
global food shortage together with economical stress poses a nutritional threat to various populations for elders food shortage affects health and wellbeing and is directly associated with immune and neurological deficiencies synthetic cells sc lipidbased vesicles composed of essential fatty acids and loaded with immunesupporting vitamins and nutrients have been suggested as economical nutritional supplements that can be produced at largescale and integrated into generic food matrices to improve their nutritional value in this research program we propose to develop nourishing sc targeted to deficiencies of the immune and neurological systems to support the aging body
|
unraveling the photochemistry of radiosensitizers and radioprotectors in free biomolecular complexes
|
dramatically increasing cancer cases around the world call for extra research efforts to improve cancer therapies radiation therapy or radiotherapy is one of the most common treatment methods a way to enhance radiotherapy is inserting radiosensitizers rss and radioprotectors rps into the patients body rss in tumor cells make them more sensitive to radiation damage allowing one to use reduced radiation doses thus minimizing side effects in contrast rps inhibit the damage of healthy cells from radiation rss and rps are actively studied mostly in clinical trials however the fundamental mechanisms causing damage or death of cancer cells are not fully understood therefore this project aims at elucidating the elementary steps of radiation damage their enhancement by rss and their inhibition by rps the technique combines beams of mixed molecular clusters and doped helium nanodroplets uniquely with synchrotron spectroscopy electron spectroscopy and ion mass spectrometry the main goals are to unravel the photochemistry of selected organic rs compounds nimorazole nimo bromoadenine wr1065 dihydrochloride metal ions mg2 ca2 k and gold rs and silver rp nanoparticles in the state of controlled microhydration and contact with dna components thymine cytosine tetrahydrofuran emission of slow electrons water fragmentation and anions formation are observables for radiation damage enhanced by rss a timeresolved experiment on the tetrahydrofuranwater complex will elucidate the ultrafast dynamics of intermolecular energy transfer causing dissociation a mechanism recently identified to play an important role in radiation damage a better understanding of the radiochemistry of rps and rss obtained with this project may help develop new schemes for efficient cancer treatment and identify new types of molecules or nanoparticles with improved rs or rp properties
|
real processing in phase change memory
|
separation of processing and memory is the root cause of the main performance and energy bottlenecks in modern computers in the pis erc stg we proposed to combine data processing and storage in the same cells to develop a novel unit called the memristive memory processing unit mmpu this unit was based on resistive ram rram which is still not commercial in large capacity a different memory technology phase change memory pcm is commercially available in large capacity for example intels optane has 15 tb memory and can serve as an appropriate technology to form an mmpu with short timetomarketin this poc we aim to experimentally demonstrate a working mmpu based on commerciallyavailable pcmthis mmpu will enable fast and energy efficient computers that are cheaper than existing computers this will impact different applications such as artificial intelligence databases and genomics the mmpubased computers will allow faster and cheaper execution of the aforementioned applicationsin this proposal we target the required technical and business steps required to develop such an mmpu and to commercialize it
|
media economics and geopolitics
|
research in political economy has documented a vast number of different media effects suggesting that the media can have a profound impact on a range of economically politically relevant outcomes yet the existing empirical work is significantly skewed towards a few countries raising concerns about the generalizability broader cross context relevance of the empirical findings further given the predominant focus on individual countries and its politics this implies limited attention is devoted to the frictions between national media national politics and transnational policy making in the myriad of areas that require collective and coordinated global action to what extent the primarily national media has concrete effects undermining global policy making across a broad range of areas or on the specific issue of climate change is an important empirical question that requires both suitable data and suitable research designs megeo will deliver on both dimensions and in the process catalyse research across multiple disciplinesthe overarching objectives of megeo are1 to develop make available a comprehensive and consistent novel data resource measuring what national media reports on and how and to what extent other countries are represented in each others media2 to characterize the extent to which national media may affect policy making in domains with clear transnational relevance that has previously been mostly ignored 3 to quantify the extent to which skewed reporting on foreign countries may have tangible economic political impacts the work is organized across three work packages that will provide a systematic topology of media focus across countries
|
lowloss fiber coupler
|
this erc proof of concept poc project aims to demonstrate a lowloss fibretochip coupler a critical component for the pis erc project qamp 101042414 while qamp focuses on achieving unity electrooptical transduction to convert superconducting qubits to optical qubits the realized product requires an efficient fibretochip coupler to extract the optical qubits our patented innovation introduces a fibretochip coupler with unprecedented low losses of 0015 db 035 which is an orderofmagnitude lower than current stateoftheart solutions achieving such lowloss coupling is vital for five out of the six major quantum computer contenders superconducting optical neutral atom ionic and colour centre qubits this development is particularly crucial for the field of optical quantum computing valued at over a billion dollars which depends on efficient fibretochip couplers to realize their basic computational functionality the successful implementation of this technology would enable the other qubit contenders to entangle and connect individual quantum processing units via a fibre network thus addressing the current bottleneck in quantum information processing that requires millions of qubits working in unison
|
identity and consent management for eu digital and data strategies
|
consentis is geared to alleviate the challenges posed by personal data sharing towards the implementation of eu regulations and strategic initiatives like eidas eu data spaces and gdpr it introduces a novel framework which offers selfsovereign identity and usercentric consent management solutions that enables users to a have full control over their personal data collection and usage and b provide informed consent through userfriendly interfaces and notifications the proposed framework is agnostic to existing services and formats and guarantees high levels of protection avoiding potential legal uncertainty through a continuous assessment mechanism for security risk and legal aspects consentis is an industryoriented project with smes and large companies covering more than 80 of the consortium and is built on a collaboration of 13 organisations from 10 eu member states and associated countries the consortium includes 2 academic institutions 9 smes and 2 large industry partners that bear strong interest and relevance to the project objectives and are highly committed in the delivery of scientific excellence and innovation in the fields of identity management and ssi consent management blockchain and smart contracts user interfacesuser experience cybersecurity and pets business and market impact and eu laws policies and regulations for human rights and technology
|
affordability and sustainability improvements by using new pricing costeffectiveness and reimbursement models to appraise innovative health technologies
|
ascertain affordability and sustainability improvements through new pricing cost effectiveness and reimbursement models to appraise innovative health technologies addresses the need of patients physicians payers regulators and manufacturers to improve the affordability and accessibility to innovative health technologies including pharmaceuticals in europe ascertain aims to enhance current methods of valuebased pricing costeffectiveness modeling thresholdsetting reimbursement and payment to set affordable prices and to facilitate a cyclic assessment of broader societal benefits including costs and risks it seeks to find a sustainable balance between access to affordable technologies the need to stimulate innovation and entrepreneurship and the need to consider the environmental impact of innovations guided by a conceptual framework integrating pricing health technology assessment and reimbursementpayment ascertain will develop openaccess easy to use policysupporting tools including i pricing models ii value assessment models and iii reimbursement models which will be adaptable to countryspecific conditions these tools will improve transparency and accountability of decisionmaking reduce uncertainty for all stakeholders reward innovation in areas of high unmet need accelerate access for patients and support longterm planning in a sustainable way further these tools will be developed tested and validated for three use cases including precision cancer medicine cell and gene therapy and medical devices class iib and iii or in vitro diagnostic ivd class d the multinational multidisciplinary ascertain consortium is complemented by an international advisory board consisting of key stakeholders with whom the policysupporting tools will be cocreated all tools will be hosted on a cloudbased publicly accessible userfriendly platform following open science principles
|
vibroacoustic model order reduction
|
vamor contributes to a more sustainable and quieter future for europe noise pollution has arisen as one of the key factors towards the degradation of the quality of life in european societies adding noise treatments commonly leads to an increase in mass andor volume usage harming the sustainability of the respective products eg leading to heavier vehicles to avoid such solutions and striving for the sustainability and optimal acoustic behaviour of products vibroacoustic design needs to be pushed earlier in their design phase additionally product sustainability can be also enhanced by exploiting the information included in sound waves emitted during their operation detecting potential malfunctions in that context efficient physicsbased sound modelling is a key enabler towards not only optimized and sustainable acoustic profiles through efficient design procedures but also affordable socalled digital twins that monitor product performance in real time to this end the overarching goal of vamor is to provide high level scientific and transferable skills training on a new generation of efficient vibroacoustic modelling techniques socalled model order reduction mor strategies to a group of high achieving competent doctoral candidates to promote a quieter and more sustainable environment this will be achieved by combining an excellent research programme with an exemplary interdisciplinary training programme vamor brings together a remarkable consortium which combines research leading academic institutions with a constantly innovating wide variety of industrial partners working on software material testing design and sound enhancement by deploying such an intersectorial multidisciplinary consortium vamor guarantees the creation of a coordinated research environment to develop and exploit novel tools for the efficient simulation of noise and vibration and promote sustainability and acoustic comfort of products
|
beyond compliance rethinking the effectiveness of regional human rights regimes
|
the european african and interamerican human rights regimes seem not to be effective visvis nondemocratic states besides undermining the international rulebased order this situation has dire implications for human rights victims conventional theories based on the experience of the european court of human rights ecthr equate the effectiveness of regional courts with compliance this perspective is inadequate to explain the status quo where illiberal states may execute individual rulings while violating the underpinning norms scholarship on the global south suggests that the experiences of the interamerican court of human rights iacthr and the african court of human and peoples rights acthpr offer an underexplored potential to increase our understanding and a great potential to draw lessons for the european context which is increasingly dealing with illiberal regimes from a compliance perspective the iacthr and the acthpr have been hardly effective yet if we take broader societal impact as an indicator their experiences might indeed provide us with important insights the project asks what are the limitations and possibilities for human rights regimes to be effective in nondemocratic contexts it starts from the working assumption that regimes can only be effective if they make full use of their oversight powers exhaustiveness and empower domestic activists in their mobilization responsiveness it tests this view by analyzing how the three regimes have enforced their norms against states engaging in 1 violence 2 legal repression andor 3 rule of law violations based on case law analysis and interviews it will develop an empirically based theory on effectiveness in three steps 1 a historical analysis to identify the three regimes founding goals 2 an empirical analysis of the extent to which they have adhered to these goals visvis illiberal states 3 a normative framework on how they can enhance their effectiveness
|
rethinking and reshaping the eus democracy support in its eastern and southern neighbourhood
|
shapedemeu sets out to rethink reshape and review the eus democracy support policies in its eastern southern neighbourhoods amidst the increasing contestation of the eu and the weakening impact of its policies in the neighbourhoods shapedemeu applies an entirely novel approach to democracy support the approach conceives of democracy support as a social practice requiring the collective democratic learning of all stakeholders involved the consortium will pilot test a democracy learning loop to create new channels and tools for interaction between the eu and its neighbours and transfer these findings into policy recommendations for an improved eu policy toolkit shapedemeu represents a multinational and multifaceted research consortium of academic think tank and civil society institutions based in the eu and the southern and eastern neighbourhoods the consortium will apply mixedmethods to collect assess and generate policies related to democracy support in the six case countries of lebanon palestine tunisia ukraine georgia and armenia we will investigate the role of eu member states key eu institutions third country actors and international organisations the project results will lead to improved eu practices in the region in all project phases the impact of gender equality digital transformations in democracy support will be examined the findings will be communicated and disseminated through shapedemeus comprehensive democracy support database and an online digital dashboard our results will contribute to the creation of sustainable tools for an eu policy toolkit that supports democracy in its southern eastern neighbourhoods thus increasing the eus accountability transparency effectiveness and trustworthiness and making neighbourhood countries more resilient equitable and responsive to local needs
|
the neural correlates of object location memory
|
remembering where things are for example where you parked your car is essential in everyday life without spatial memory we would continuously be engaged in looking for our car keys phone or glasses despite its obvious importance a lot is still unknown about object location memory olm this proposal aims to uncover mechanisms underlying olm specifically taking into consideration the influence of object knowledge on olm eg if an object is owned or familiar these factors will be explored by examining individual differences sex differences and ageing in wp1 and testing the neural correlates of olm in wp2with this aim the following specific objectives have been establishedtest individual differences in olm sex differences and ageing conducting online studies to understand how o reported sex differences relate to the cognitive mechanisms involved in olm o ageing affects the cognitive mechanisms involved in olmtest how object knowledge eg familiarity and ownership affects olm in fmri studies we will concurrently acquire neural activation and memory data to oexplore the brain areas involved in olm otest whether object knowledge effects on olm are reflected in neural activity of brain areas responsible for the representation of peripersonal reachable and extrapersonal out of reach space otest whether neural activation at encoding is predictive of spatial memory error otest whether these effects occur upon memory retrieval or already at the stage of encoding ie during object perceptionbuild a dynamic causal model of typical healthy olm which can be used as a baseline for studies on atypical olm eg dementiathe results obtained from this multidisciplinary project will be relevant in the fields of gerontologydementia research cognitive psychology cognitive science cognitive neuroscience and neuropsychology and will inspire future applications for populations with atypical olm
|
era chair in internet of underwater things at labust
|
uwinlabust project aims to create conditions and opportunities at the university of zagreb faculty of electrical and engineering and computing unizgfer in croatia for high quality researchers and research managers to move and engage to achieve excellence in a sustainable manner within the area of internet of underwater things iout at the laboratory for underwater systems and technologies labust the objectives of the uwinlabust project are 1 to recruit prof roee diamant from university of haifa as era chair holder who will establish his own team consisting of 3 postdocs a technology transfer officer and a group leader 2 to achieve excellence in the research area of iout a network of smart interconnected underwater objects with particular focus on 3 strategic research domains a underwater sensor communications b underwater acoustic signal processing and c underwater collaborative autonomy 3 to ensure sustainability of the achieved excellence and 4 to increase uwinlabust group scientific involvement and visibility these objectives will be reached through a set of strategic measures expert visits and outgoing study visits for providing knowledge transfer research innovation management trainings and establishment of technology transfer office for transferring results from academia to industry new msc and phd courses to ensure knowledge transfer to new generations organization of workshops summer schools and conferences for strengthening links to industry endusers and the scientific community ministry of science and education of croatia has provided a letter of commitment guaranteeing additional financial support for equipment and infrastructure to uwinlabust project from european structural and investment funds dean of unizgfer also committed to ensuring additional financial research support
|
leap in advancing of critical quantum key distributionspace components
|
laiqa comes as a technology intensive research and innovation action aiming to develop and advance critical components and technologies necessary to build a global spacedbased quantum network laiqa envisions to realize unconditionally secure quantum communications over long distances bringing functional qkd components together with advanced system integration techniques towards deployable spaceqkd systems the projects objectives will include the development of spacedeployable highbrightness 1550 nm entangled photon pair source epps a spacesuitable decoy state bb84 prepare and measure pm source a photonic integrated epps for nextgeneration onboard sender stations a quantum memory for longdistance entanglement distribution an advanced fibercouplingadaptive optics system for converged spaceterrestrial qkd segments and software components towards the optimization of laiqa architecture the project will demonstrate pm and entanglement based qkd systems both in labterrestrial fso testbeds and in field demonstrations in helmos optical ground station ogs laiqa will also mobilize its consortium to prioritize standardization activities that focus on space components for pm and entanglementqkd consider interfaces and parameters for them to propose specification standards and potentially trigger new standardization activities within eu
|
nature for insurance and insurance for nature
|
naturebased solutions nbs can provide means to regulate ghg in the atmosphere mitigate climate hazard risks through mass stabilisation water flow regulation wind dissipation and temperature regulation remove particle pollution and improve air quality protect soil and biodiversity and enhance climate resilience the naturance project will examine technical financial and operational feasibility and performance of solutions that are built upon and combine disaster risk financing investments with naturebased solutions to this end we will stimulate dialogues knowledge sharing and mutual learning across different areas of policy and practice our ambition is not only to produce a comprehensive and collaborative assessment of naturebased insurance and investment solutions from societal and business perspective our ultimate goal is to encourage adoption of jointly elaborated principles performance metrics and recommended approaches to analysis and design in accordance with eu framework for sustainable finance the project will establish a network of existing networks by connecting existing major knowledge networks and fostering crossdomain knowledge sharing and collaborative marketplace for innovative naturebased insurance investment solutions initiate and organise innovation finance and policy labs seeking to assess existing and explore new areas for insurance investment solutions and revenue models supporting nbs analyse policy and governance conditions that are conducive to or hamper adoption of sustainable and equitable innovative green insurance and investment solutions for nbs and identify examples of inspirational practice and policy reforms unlocking their business potential and scaling up their deployment analyse models methods scenarios and metrics used for assessing riskreduction performance of nbs as well as their wider societal benefits and contribute to a better integration of ecosystem and economic risk modelling build awareness and capabilities for green financial innovations so to creating conditions for inclusive and transformative change in regions embarked in the mission on climate adaptation societal transformation
|
tracing queer citizenship over time ageing ageism and agerelated lgbti politics in europe
|
sexual and gender diversity are constitutive elements of democratic societies which have been targeted by extremeright populism and other antidemocratic forces taking queer citizenship as a set of criteria through which democracies can be evaluated trace explores the extent to which the eu has influenced local political and sociolegal advancements in lgbti rights narratives and experiences over time to respond to this aim trace develops an innovative agesensitive analytical lens focused on ageing ageism and agerelated lgbti politics through which progress and backlash in countries that experienced substantial changes in their intimate citizenship regimes will be investigatedtrace uses a multiscale lifecourse approach centred on genderedsexed processes of ageing in the context of a rapidly changing europe lgbti elders carry a unique embodied knowledge of struggle and resistance offering a precious lens through time from once criminalized outlaws to the intimate citizens of todays eu lgbtifreedom zone who outlasted a variety of challenges including the aids pandemic and related stigma the countries included in this research are portugal italy greece malta and slovenia offering a comprehensive overview of changes across time and space in europe including the impacts of religion and secularism traditional and advanced intimate regimes and the relation to the eu lgbti evolving framework with a focus on the south as an imagined political space of silence and resistance the research enables an indepth portrait of different regions of southern europe today grounded on the life stories of older adults whose lifespan accompanies these changes their shared and untold past of oppression will inform scholarly knowledge regarding current and future policymaking particularly timely in a rapidly changing europe grappling with the expansion of populism and antigender backlash
|
synthetic neurons and artificial photoactivated synapses
|
the brain is a complex network of interconnected neurons that communicate through synapses synaps aims to for the first time mimic such synapses using liposomes as artificial cells and visible light to trigger a signal from a sender to a receiverliposome mimicking such communication processes will help with understanding how complex natural emergent properties arise and could ultimately allow for the construction of a chemical computer synaps will excel beyond the stateoftheart by maintaining chemical isolation between liposome interiors ensuring local timebound communication between connected liposomes and using light as an external stimulus and fuel these concepts are essential to construct artificial tissues that can communicate on an individual liposometoliposome basis in contrast to the stateoftheart where communication generally occurs with the bulk solution to achieve this a messenger compound will be locally photosynthesised through transmembrane electron transfer by porphyrin dimers that portray a chargetransfer excited state the liposomes will be organised into a synaptic cleft through the use of synthetic complementary clustering compounds that provide stable adhesion between sender and receiver liposomes the messenger compound will be recognised by reversible and selective membranespanning receptors in the receiver liposome that will output the signal through fluorescence in addition a reaction cascade network will be constructed involving the messenger to produce an artificial action potential that is a transient peak in the concentration of the messenger ensuring a timebound dissipative signal altogether synaps will provide advances in systems chemistry by providing a nanoscale platform for communication between chemically isolated systems but also results that are useful for applications such as lighttochemical energy conversion chemical sensing and smart drugdelivery
|
innovations in detecting and disrupting crimeasaservice operations
|
safehorizon offers computer law enforcement agencies leas emergency response teams certs and computer security incident response teams csirts a toolbox with underdevelopment and improved opensource solutions that will be simple to plugandplay maintain and adapt saferhorizon aims to disrupt caas by harnessing intelligence collected from internetfacing services the clear deep and dark web public dumps and leaks from ransomware groups and hacking forums and channels as well as datasets from leas and security providers and using machine learning ml to identify correlations and extract actionable evidence that can be used in court beyond crawling for information safehorizon will actively search for possible leaks of information on illegal services forums and software that would allow leas to track down users developers and operators safehorizon will deliver i a toolkit that is broken down into individual and interoperable easytouse tools in the form of docker containers ii a monitoring platform that integrates the output of these tools iii a correlation engine to find the connections among diverse and big datasets and iv datasets and notebooks that will be shared with all eu leas and vetted organisations and companies to enable the easy uptake and processing of data to deliver tangible results moreover safehorizon aims to give cybercriminals a taste of their own medicine by eg spreading disinformation on hacking carding forums and channels to dismantle their rings of trust
|
multisensing tool for minimally invasive surgery
|
palpable introduces a new generation of mis minimally imvasive surgery tools a novel tactile sensing probe as a palpation tool for identification and visualization of tissue abnormalities mis has several advantages reduced tissue damage postoperative analgesic requirements blood loss decreased hospitalization time better cosmetic results but there is limited or none visual haptic and tactile feedback insitu along with issues of tool dexterity these issues can lead to accidental tissue damage the probe diam 5mm length 1520mm incorporates multiple sensing modalities and a thin flexible pneumatically actuated endeffector 3dof 180deg with distributed sensors for distributed tactile sensing the probe consists of the photonic sensing elements and a sphere held at the end of a circular tunnel by a steady flow of air the sphere is free to rotate in all directions and can move into the channel when pressed against the airflow when rolling over tissue the displacement depends on the tissues stiffness and is picked up by the optical fibre above it optical intensity variation in the sensing element is used to identify tissue stiffness variations the principle of measurement used is extrinsic light intensity modulation provided through optical fibres a nonplanar photonics circuit 200m waveguide 8bit colour depth for haptic sensor array is developed and interfaced with the probe this circuit will be engraved on ultrathin polymeric foil the foil sensing elements are distributed around along the probe for multiple sensor inputs for palpation ie stiffness distance and curvature that are then fused to provide the overall tissue situation using thin foils allows for ease of integration with the probe and a straightforward manufacturing process to enable low cost in large volumes the end effector is made from disposable or sterilizable materials both options will be explored for recyclability or reusability respectively
|
scalable fullcycle marine litter remediation in the mediterranean robotic and participatory solutions
|
seaclear20 will develop a holistic approach to address the full cycle of marine litter towards the mission to restore protect and preserve the health of our oceans seas and waters by 2030 to this end we aim to prevent and reduce marine litter pollution particularly plastics and microplastics in the mediterranean via i community activation citizen empowerment and participatory practices for identifying sitespecific measures for marine litter prevention and reduction supporting the implementation of the wfd and msfd ii scaling up and demonstrating the seaclear20 system an innovative solution with teams of autonomous intelligent robots for effective monitoring and collection of marine seafloor and surface litter iii providing solutions for valorization of the collected litter via better sorting and recycling iv adding novel dimensions in policy making by providing evidence for new legislation and the implementation of existing rules to achieve good environmental status and v accelerating the uptake of our solution by demonstrating its scalability and replicability to the mediterranean basin and beyond in three fullscale demonstrations three pilot tests and at least five associatedregion projectsseaclear20 impact ranges from the reduction of upstream and beach litter via public awareness and citizen activation through effective litter monitoring using both robotic mapping and public reporting in a gamified app to direct collection of at least 57 of existing litter in the areas covered by the robot teams with options for valorization the singular selling point of seaclear20 is our unique blend of technological innovation ii iii communityactivation i and policymaking ivwe achieve all this by exploiting consortium expertise in public engagement policymaking robotic perception and control artificial intelligence marine technology and operations and litter sorting and recycling
|
wartime demographic engineering war nationalism and population politics in putins russia
|
wardem explores the interconnected yet complex and contradictory relationships between war nationalism and population politics in putins russia the project provides an innovative analysis of the processes and practices that reshape the population in times of war and through the war challenging geriatric peace theory wardem examines the ways in which interstate war entails new demographic strategies more precisely it examines how in the context of a declining and ageing population an aggressor state may use war to expand the population by force through territorial annexation and the intake of displaced persons a strategy that is particularly relevant when these people are seen as ethnic kin wardem undertakes an interdisciplinary systematic case study of a critical case analysing russian population politics in the context of the war on ukraine from its outset in 2014 to the end of 2023 developing a transdisciplinary methodology that synthesises recent insights from nationalism studies political demography peace and conflict studies and illiberalism studies the project combines a focus on political discourse with an analysis of population policies that is citizenship immigration demography and ethnic policies as reflected in legal acts and policy documents these policies are part of a wartime demographic engineering which allows russia to integrate new populations forcibly while seeking to divide the ukrainian nation and weaken the ukrainian state thus the project develops a model linking the analysis of an authoritarian states aggressive foreign policy with the reshaping of its population and changes in its nationalist discourse wardem is a timely project responding to the current challenges facing eu foreign and security policy a rapidly evolving geopolitical environment the influx of refugees from ukraine and economic impact of war all calls for investigating the dynamics of russian expansionism and revisionism
|
cultivating color harnessing bacteria for sustainable pigments in circular economy
|
confidential
|
metabolic flexibility in drought leveraging portulaca for defining design principles for a combined c4cam pathway
|
rising heatwaves and drought are severely affecting the capacity of crops to retain water and capture co2 during photosynthesis resulting in global yield reductions one of the most promising approaches to enhance crop production in stressful conditions is to synthetically modify the photosynthetic capacity of plants in nature some lineages have evolved mechanisms like c4 photosynthesis and the crassulacean acid metabolism cam to cope with some of these aspects while c4 species are extremely efficient at co2 fixation but vulnerable to severe drought cam plants are less productive but very capable of coping with significant drought periods engineering a joint c4cam system that uses cam features to fight drought while still relying on the power of c4 can be a gamechanger to increase crop resilience for decades the coexistence of c4 and cam was considered incompatible in nature an exception to the rule is found in the genus portulaca where c4 species can trigger cam when droughted despite the huge bioengineering potential of portulaca the molecular enablers that allow for c4cam to exist in this clade remain elusive previous phylogenetic and morphological studies across portulaca indicate the combined c4 kranz anatomy and cam succulence leaf anatomy might be the main facilitator of c4cam by combining anatomical studies cell specific metabolomics and genomics with synthetic biology i aim to identify the basic molecular determinants of the c4cam switch in portulaca and to leverage this knowledge to transfer cam anatomical features to c4 species outside portulaca as a proof of principle this will set the basis for new rounds of engineering to achieve a fully functional c4cam switch metacam will provide a quantum leap to our understanding on how incompatible metabolic pathways can be designed built and integrated in multicellular organisms which is broadly applicable to crop engineering
|
european literatures and gender from a transnational perspective
|
the aim of euterpe european literatures and gender in transnational perspective is to offer an innovative approach to rethinking european cultural production in the light of complex social and political negotiations that are shaping european spaces and identities at present euterpe intends to do that by bringing together gender and transnational perspectives within an interdisciplinary approach to literary and cultural studies euterpe proposes to train and supervise 9 esrs in interdisciplinary transnational gender focused literary studies the research is organized into 8 wps within four main areas 1 transnational womens literature and its travels points of entry and pathways wp 1 wp2 2 translational genres crossing borders in gender form space and identity wp 3 wp4 3 transnational women intellectuals multilingualism and decolonising european pedagogies wp 5 wp6 4 transnational literature and cultural production intermediality as a form of translation wp7 wp8 the esrs academic training will include two supervisors from cooperating universities a compulsory secondment period and an industrial internship with an associated partner organization to support bespoke employability enhancement major impact outputs of the project 9 phd theses a coproduced open source dictionary of transnational womens literature in europe with key concepts and biobibliographic entries on leading representatives of the field and a digital catalogue and podcast library which will make accessible all relevant material collected during the creation of the dictionary as a complex project which brings together research training and open access publications of innovative and longlasting value euterpe will have strong influence in the intersecting fields of literary and gender studies as well as in the connecting fields of transnational studies translation studies migration studies and european studies
|
ontologies of waste a relational study of how waste comes to matter for humans society and future
|
the future world imagined by the circular economic model is a world without waste provided that materials and energy circulate efficiently enough through society the project wastematters disrupts the wasteasresource paradigm prevalent in the circular economy related politics business and scholarship alike and examines our contemporary trashscapes beyond the ideal of the eternal redemption of waste its novel approach is to analyse the leaky realities of waste as integral to the human condition and as constitutive of society the project explores the implications of waste throughout society and what waste does forto us what kind of relations agencies and spatiotemporal scales it assumes prompts enacts and sustains to what kind of futures society commits itself with it and what humans become with waste the project develops a new methodology morethanhuman ethnography to be able to attend to the vibrant nature and active role of waste in how we live together the research will be carried out through four substudies across various sites in sweden and finland which function as important nodal points in the management and circulation of wastes households businesses biogas plants waste incinerators and a nuclear waste repository and to attend to the multiplicity of waste the project will focus on four kinds of waste food waste plastic waste waste incineration ash and nuclear waste through the research design the project will generate groundbreaking insight into waste as both constitutive of society and as something that disturbs it the empirical methodological and conceptual insights will be combined to enable a leap in theory building to develop a new relational theory of waste that pays attention to the multiple spatiotemporal scales of society and human actions ultimately leading to a paradigm change from the circular economy to waste matter society
|
datadriven aiassisted digital framework for enhancing circularity in manufacturing
|
the data4circ project aims to enhance circularity within the manufacturing sector to facilitate decarbonisation whilst improving competitiveness and boosting the adoption of rstrategies these objectives will be achieved by providing the sector with the proposed data4circ solution a humancentred collaborative digital framework that leverages the power of data and cuttingedge digital technologies for assets digitalisation this framework will comprise a federated data spaces b digital models of the circular value chains and products c digital product passport dpp and d an aiassisted endtoend lca tool the integration of these tools into a single framework will improve data interoperability and accessibility therefore boosting the collaboration and the establishment of circular value chains to do so e ontologies and semantic models will be leveraged and proper userfriendly interfaces will be developed furthermore the data4circ solutions will be based on existing standards and architectures to maximise their adoption and impactspecial focus will be placed on social aspects for the transition to circular business models which prioritise the needs expectations and experiences of endusers by embracing the social innovation paradigm human involvement throughout the project is boosted through cocreation and covalidation activities moreover an upskilling and reskilling training programme will be designed and conducted to facilitate the uptake of digital tools in the manufacturing workforce during the project and beyond its completion validation and demonstration of the data4circ solution will be achieved via three use cases thereby consolidating successful progress from trl4 to trl6 the selected use cases are circular value chains in manufacturing sectors with high impact potential and significant room for improvement regarding the field of circular economy the electronics plastics and automotive sectors
|
event driven active vision for object perception endeavor
|
computer vision leveraging deep learning in the last decade has achieved unprecedented progress however it is largely relying on datasets of still images thus using passive vision on the contrary biological vision is a fundamentally active process of exploration to disambiguate objects and yet the potential of active vision for robotics remains underexploredthe endeavor project seeks to redefine traditional static image analysis within fast online robotic applications this project integrates the computational models of sensorimotor contingency theory oregan and noe 2001 with eventdriven perception and neuromorphic computing sensorimotor contingency represents the dynamic relationship between an agents sensory inputs and motor actions in the environment active sensory data generation naturally aligns with eventdriven perception tracking moving objects via agentgenerated events while neuromorphic computing minimises latency and energy usethe humanoid robot icub will hold objects and examine them from various perspectives through eye and wrist movements the project capitalises on bioinspired hardware and software solutions ultimately aiming to reduce computational demands power consumption and latency in intelligent systemsendeavor offers three significant contributions to computer vision and robotics 1 it introduces active vision strategies that enhance object perception 2 it integrates eventbased visual sensing with rapid and efficient parallel computation leveraging neuromorphic computing principles 3 the project establishes a benchmark that allows for both qualitative and quantitative evaluations fostering comparisons among various approaches including framebased eventbased and spikingbased systemsthe importance of this approach lies in the effort to reduce the storage of massive amounts of data while aiming for mw of power consumption
|
endtoend multidisciplinary optimal design for improved personalized bioactive glassceramic bone substitute implants
|
the musculoskeletal system is extremely vulnerable to ageing and traumatic events and common clinical conditions often exert a high burden on the clinical system for patients requiring bonesubstitute implants to treat criticalsize bone defects new solutions are required for meeting important unmet needs personalised solutions for better clinical outcomes improvements in materials to ensure higher mechanical reliability without compromising bioactive and bioresorbable properties optimised manufacturing technologies for materials and products of high reliability and qualityrebone is a fouryear doctoral network that aims to innovatively train a new generation of researchers to develop a multidisciplinary optimisation process to provide technologies for 3dprinted personalised bone replacement implants based on bioactive ceramics the ultimate scientific goal is to construct a platform of computational tools that will enable clinical experts to produce customized bone graft substitutes for the treatment of criticalsize bone defects this innovation will ensure that an ideal treatment solution is found on a patientspecific basis in terms of i mechanical and mechanobiological performance ii surgical implantability and iii manufacturing process reliability furthermore rebone will develop stateoftheart in silico models based on advanced computational methods and advanced characterisation and validation techniques to obtain personalised implants with a surgical planning visualization system in mixed reality with the following characteristics i tailored and reliable mechanical and physical properties ii best osteointegration capability iii targeted mechanical physical and mechanobiological functions with patientspecific constraints taking into account the loadbearing anatomical location four selected clinical cases will be used as demonstrators of the optimization design and manufacturing process
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.