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carbon negative concrete 3d printing
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concrete accounts for 8 of global co2 emissions industry players are under pressure to meet the net zero co2 emission target by2050 and seek all possibilities to reduce their co2 emissions in light that the industry is shifting towards prefabricated elements thatcan be made by 3d concrete printing however 3d printing today has significant limitations hyperion offers a breakthroughtechnology that will revolutionize the concrete 3d printing industry the solution solves all the bottlenecks of the industry byproviding a green carbon negative 3d printable concrete that is code compliant a robotic printing head that monitors the printingprices and a new design methodology that shortens design time and ensures printability overall hyperions technology can reducethe co2 emissions of concrete element production by 100 offering it at 50 of the todays cost of 3d printable concretes that aremore carbon intensive than conventional concretes today
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knowledge for improving indoor air quality and health
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khealthinair aims at the assessment of the indoor air quality iaq effects in health on the basis of an extensive monitoring campaign of chemical and biological indoor air pollutants in several very representative at eu level indoor locations together with a deep research on their sources interactions and main correlations with health problems by means of theoretical analysis clinical trials and tests includes in vivovitro approaches moreover project will deliver affordable and easy for implementation measurements to monitor and improve current iaqthe project will deliver structured knowledge coming from both the monitoring characterization and research stages formed by extensive and accurate data qualitative information and guidelines in an easy and fully open access format to support public authorities policy makers and many other collectives project will also deliver innovative equipment and associated tools to the citizens as main final users enabling them to monitor indoor air quality for identifying health risks and suggesting suitable solutions to mitigate them the advanced knowledge will be obtained by means of the deployment of a set of fully complementary activitiesthe organization and publication of the knowledge generated in a fully open access platform looks for being considered a reference in accuracy and simplicity to favor easy consultation from public authorities and policy makers and support the definition of new legislations regulations and standards khealthinair ensures the integration of the existing legislation eg in work places within a comprehensive proposition of new indoor air quality standards leading new sciencebased regulations khealthinair will deploy activities leading to effectively engaging most of the collectives concerned verifying that project results will impact as it is expected project khealthinair is part of the european cluster on indoor air quality and health name and acronym to be decided
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optical probing of charge traps in organic fieldeffect transistors
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organic electronics offers huge potential for fabrication of largearea lowcost and efficient devices solution processing and availability of a vast library of organic semiconductors enables to exquisitely tailor properties to each application while minimising waste of materials and maintaining low temperatures during processing thus reducing energy use although organic electronic devices have reached the market in large and flexible displays their real potential in biomedical applications sensing and sustainable electronics remains unrealised crucial fundamental building blocks such as organic fieldeffect transistors are still hindered by limited charge mobility and unpredictable outcomes with new material recipes organic semiconductor performance is significantly reduced by formation of charge traps which are local defects in the material or interfaces that remove charge carriers from the device conduction channels and obstruct transport accurate control of charge traps is critical to boost device performance but they are notoriously difficult to identify characterise and rationally engineer optocharge adopts a novel approach to optically stimulate traps with high spatial temporal and energy resolution and reveal the key parameters for charge trap optimisation the project systematically explores crystallinity morphology material blends dopants and electrolyte gating to dissect the origin of traps and offer effective strategies to boost device performance the proposal leverages unique interdisciplinary synergies between applicant and host and provides an outstanding research setting to fulfil the full potential of the applicant and launch his academic career
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intelligent weld inspection
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periodic inspection of the integrity of welds is essential for maintaining safe and efficient operation of critical assets methods based on ultrasound have numerous advantages they are fast accessible and nondisruptive but they meet serious obstacles when used on thick welds with a complex microstructure the h2020 advise project developed and demonstrated techniques to address these challenges in the nuclear energy context for most of these the knowledge of the internal material structure of the weld is essential building up foundations laid by advise iweld aims to progress towards implementing the imaging and characterisation methods insitu and broaden their application scope beyond the nuclear energy sector the project will combine insights from a wide spectrum of industries to construct a comprehensive weld library which will be used to train an ai model predicting the internal material structure of the weld these predictions will be used in further refined inversion and imaging algorithms to deliver a comprehensive inspection planning workflow the ambition of iweld is to transform the way to perform ultrasonic inspection on complex welds across several branches of industry and to deliver open tools to support their development
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cancer tailored next generation cellular therapies
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cellular therapies are commonly used to treat hematological cancers but have yet to be established in solid oncology their evolution has been fuelled by hypotheses derived from cell biological observations in cancer models most approaches however will either never enter clinical development or fail clinical testing often due to inadequate models of disease and their lack of relevance to human biologyin cataclis i propose the first unbiased development of cellular products based on patient characteristics in order to address this enormous translational gap and ultimately provide more effective cell therapies to patients with solid cancers cataclis will herald a paradigm shift in cell therapy by reversing conventional modeltopatient innovation forward translation to patientgenerated ideas tested in patientderived models into clinical trials reverse translationi have discovered novel approaches to improve t cell function which resulted in a clinical trial and established me as a leader in the field of cellular therapies the challenge i will now face is to move beyond model bias and integrate cancer heterogeneity across patients and entities in cataclis i will use single cell data sets from patients to inform the design of next generation cellular therapies capable of overcoming current limitations in solid cancers namely 1 access to tumor tissue 2 target antigens selection and 3 immune suppression to maximize clinical relevance cataclis will use patientderived materials from hypothesis generation to in vivo testing this will enable me to create cellular products tailored to the patients cancermy research will not only result in novel cellular products for further testing and development toward clinical trials but it will also serve as a resource for the development of innovative therapies based on patient data contribute to the european open science objectives and reduce the burden of animal experimentation
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enabling interoperability of multivendor hvdc grids
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to unlock multivendor hvdc grids and foster the transition of the european energy sector at large scale interopera proposes a coordinated approach between a diverse highlevel group of industries at the forefront of res development and grid management 4 hvdc vendors 8 tsos 2 wind turbine vendors and 3 wind park developers bring their industrial knowledge and practical abilities to make future hvdc systems mutually compatible and interoperable by design and to improve the grid forming capabilities of offshore and onshore convertersforeseen and planned hvdc projects will be analysed to define a demonstrator case study the resulting systemlevel design will be usable as a guidance to coordinate offshore network planning this new way of framing the european grid architecture and topology will ensure forward compatibility for future seamless system expansioninteroperability of control and protection systems will be derisked through the execution of all necessary activities concurring to the implementation of a realtime physical demonstrator concrete results will be delivered through this practical work detailed functional specifications for each subsystem standardised models simulation platforms and interaction study processes multivendor cooperation agreements those frameworks will be generalised into operational and strategic tools available to all european stakeholders for the development of multiterminal hvdc grids that will enhance offshore wind development and integrationsolutions for multivendor project procurement compliant with existing and future regulations standards and laws integrating the technical specifications and interoperability assessment tender stages will be provided to pave the way to the first reallife projects in europeexternal stakeholders will be involved in twoway consultation workshops to maximise the uptake of interoperas key exploitable results recommendations to grid codes and standards will be issued
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the embodiment of racialization running muslim women and the sense of nonbelonging
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muslims are the focus of political anxieties in europe and the us over the last decade numerous studies have documented the racialization of muslims and the impact of those discourses on those identified as such yet the embodied and sensorial dimension of the racialization of muslims remains largely undertheorized embrace posits that to better understand and by extension tackle the effects of racial discrimination in everyday life we need not only to attend to statistics of reported racism or narrated accounts of racism but also to the sensorial and bodily experience of it this project takes recreational running as a fruitful angle to consider the embodiment of race the leisurely activity of running enables an investigation of the effects of racialization on the relation to ones own body environment and to other people the research design utilizes a multimodal ethnographic approach to reveal the embodiment of social hierarchies in social interactions among muslim recreational athletes this project has two main objectives 1 conceptualize how dispositions of nonbelonging shape outdoor activities such as running and vice versa by analysing movement and narratives of movement conceptualempirical goal and 2 to examine and theorize the processes through which the multisensory dimensions of racialization become embodied theoretical goal by proposing a knowledge transfer between the researcher leiden university the netherlands and university of california berkeley usa this project aims to contribute to the theorization of embodied senses of nonbelonging
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purine sensors as novel pointofcare devices for seizures and epilepsy
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epilepsy is the most common chronic brain disease affecting 70 million people worldwide accurately diagnosing epilepsy remains a major clinical challenge due to the lack of noninvasive molecular diagnostic tools purinergic signalling via extracellularly released adenosine triphosphate atp and its downstream purine derivatives is increasingly recognised to contribute to increased hyperexcitability states in the brain and thus seizures hence these can be potentially identified as novel promising therapeutic targets for the treatment of epilepsy but also as a source of diseasespecific biomarkers however the diagnostic potential of purinergic signalling for epilepsy remains unclear and current methods of detection are either unsuitable for pointofcare application or lack disease specificity employing a multidisciplinary approach including sensor development testing in preclinical models of epilepsy and testing in patients we will develop a new userfriendly pointofcare sensor which allows the measurement of specific purines and evaluate the diagnostic potential of blood purine expression changes combining my research experience in the development of biosensors with the expertise of my primary dr tobias engel rcsi and secondment prof nicholas dale university of warwick prof norman delanty beaumont hospital prof felix rosenow frankfurt university supervisors on purinergic signalling and the development diagnostic devices atpsensor will increase our understanding of purinergic signalling and provide new tools to support the diagnosis of epilepsy the skills acquired during the research project the excellent training record of the supervisors and host institutions and the outstanding resources for learning and development available at rcsi and collaborator institutions will give me the tools necessary to become a highly employable neuroscientist
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risks resources and inequalities increasing resilience in european families
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the problem that reusilience tackles is of lack of adaptive capacities or resilience in some families the context is of fastpaced changes in labour markets to which families are key responsive mechanisms cushioning potentially negative impacts and enablingdisabling risktaking but some families cannot respond the project answers 2 research questions what challenges and difficulties are created or exacerbated for families by labour markets in the new world of work and how do families try to overcome them how do policies contribute to family resilience especially in terms of their inclusiveness flexibility and complementarity to answer these questions reusilience looks at what different families actually do in situations calling for adaptiveness eg need to change labour supply need to engage in training and places this in a social and policy context through both paneuropean analyses of existing data and new focus group research in 6 different countries be es hr pl se uk the project will identify the level of risk and socioeconomic insecurity faced by families across europe their relative capacity to absorb socioeconomic shocks and the role of policy the project is organised in 2 pillars a stocktaking pillar and a policy lab the pillars are designed to closely interlink in terms of evidence flow and mission to share some methodologies and to have inbuilt pathways to impact the lab involves citizens and experts directly in policy review and problem solution and also uses simulations and other methods to roadtest policy solutions among the outputs are a compendium of the risk situation of europes families a series of dynamic analyses of actual risk behaviour accounts from families about how they view risktaking and tradeoffs between work and care critical reviews of policies a questionnaire on family resilience taken to proof of concept stage a set of policy proposals and roadmaps for their implementation
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batterbattery passport for resilient supply chain and implementation of circular economyy passport for resilient supply chain and implementation of circular economy
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the battery although central to the green transition of road transport currently suffers from a supply chain that lacks traceability sustainability resiliency and circularity critical raw materials crms are essential for battery manufacturing the explosive growth of electric vehicles driven by climate neutrality policy objectives will pressure the crm supply chain and increase eu dependency on third countries resulting in decreased competitiveness for eu automotive and battery manufacturers implementing the digital battery passport dbp concept in the battery value chain could resolve these issuesthe main goal of the base project is to develop validate and implement a working dbp service as mandated by the regulation this will be achieved by exploiting data collected through a number of constantly evolving tools and methods ensuring a transparent secure and costefficient platform operation while also catalyzing the growth of circular businesses base will develop transparent methodologies to calculate battery performance and esge indicators ensuring traceability down to the crm level throughout the entire battery value chain in the physical domain this will be achieved through the mass balancing approach on the data management side by exploiting distributed ledger technology base will ensure builtin data authenticity verification along the value chain with no data duplication avoiding data manipulation assuring privacy by design and promoting data interoperabilitythe dbp will provide uptodate and accurate data on battery performance indicators remaining useful life dismantling material composition and safety this will allow for an increase in the useful service life of batteries and more efficient recycling which will enhance resource efficiency reduce waste and decrease eu dependency on crms from third countries the applicability of the dbp will be demonstrated through four pilot use cases
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unravelling the history of undersea oceanic plateau volcanism and its environmental impact in earths past
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oceanic plateaus are amongst the largest geological phenomena on earth and their undersea volcanic formation had profound environmental effects such as climate warming and ocean anoxia whilst huge progress has been made to link their landbased counterparts continental flood basalt provinces with climate change and mass extinctions oceanic plateaus have been comparatively understudied due to their limited accessibility and relatively benign ecological impact yet plateau volcanism triggered severe climatic and environmental disruption but the precise mechanisms by which they influenced the earths surface are unclear further most known oceanic plateaus formed in the cretaceous with their likely existence and environmental impact earlier in earths history seldom consideredthe seavolc project utilizes my expertise in studying past environmental crises and geochemically fingerprinting largescale volcanism to reconstruct the mechanisms by which oceanic plateaus triggered global change and for the first time investigate the history and impact of older plateaus that no longer exist combining inorganic and organic geochemistry i will create global maps of tracemetal nutrient disruption and biological productivity during times of cretaceous and triassic plateau activity resolving the relative environmental impact of this process vs co2 output and warming is critical to understand whether continental and oceanic volcanism influenced the earth system differently and why the former was often more lethal stateoftheart geochemical proxies that have recorded cretaceous episodes of undersea volcanism will be applied to siluriandevonian sedimentary archives of cretaceouslike anoxic events showing whether earlier environmental crises were also linked to plateau formation for the first time exploring this possibility provides a unique new perspective how the earths interior and its interactions with surface environments have evolved over time
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interoperability network for the energy transition
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interoperability depends on cooperation of multiple domains while for the energy sector technical interoperability is quite well established interoperability of functions and businesses needs more attention even when standards are defined and interoperability models agreed framework setters product developers and users need to agree on their deployment and make sure that solutions are compatible with definitions the interoperability network for the energy transition project intnet establishes an open crossdomain community bringing together all stakeholders relevant for the european energy sector to jointly work on developing testing and deploying interoperable energy services the community will be formally established to exist beyond project lifetime with a comprehensive fair knowledge platform and a series of attractive events it guides those who deal with the heterogeneous interoperability landscape of energy services to support ongoing harmonization of energy services intnet will institutionalise an assessment methodology and maturity model imm involving legal and regulatory bodies from the beginning and constant exchange of interoperability initiatives and standardization bodies will build a deep consensus on how european governance and industry can foster interoperability at all levels starting from an extraordinary well balanced and connected consortium of researchers framework setters eg ministry and eu wide associations standardisation and communication experts intnets community approach guarantees wide outreach intnet will establish a framework for interoperability testing in ongoing projects and harmonize test procedures in a network of closely cooperating selfsustained testing facilities energy service solutions based on the novel imm and tested according to the intnet certification process will be awarded with a widely known quality seal for interoperable smart grid and energy products working title intnet approved
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concept development of a system for pods and podcarriers to be used as moving infrastructures mainly for rail but as well for road and ropeways
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two major issues of secondary lines rail transport are need to change the train for many destinations and to be bound to a timetable pods can be used to adopt rail transport better to the users demand by higher flexibility and efficiency as well as realising ondemand rail transport the project pods4rail aims to develop a concept for pods and podcarriers on railway in order show the approach podcarriers are serving as a moving infrastructure and the pods are loaded and locked on them for the transport the main focus in pods4rail is the rail podcarrier which is presented in detail nevertheless podcarrier for road and ropeways are taken into consideration on a conceptual level to ensure the transferability of the concept related use cases and business cases are identified and analysed
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from silk to sealant the production of an enhanced biomedical silk glue biopolymer from genetically engineered silkworms
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advancements in postsurgical healing are a major topic in biomedical science and require innovations in materials science in many medical procedures current medical glues are more efficient than traditional sutures but they still lack sufficient wettolerant adhesive strength biopolymers are naturally derived and biocompatible and present enormous potential for applications such as tissue glue to address the adhesive challenge we propose gemsilk an innovative and interdisciplinary framework integrating analytical techniques of material science with genetically engineered silk glue our key objective is to develop a caddisflyderived and inherently wettolerant aquatic silk glue recombinant protein expression system in the domestic silkworm bombyx mori utilising crisprcas9 caddisfly aquatic silk glue dna motifs will be inserted into the silkworms silk gene the resulting stable mutant lines will produce commercial quantities of wettolerant silk glue by training through research and a secondment at the lab of supervisor seibs collaborator i will gain essential stateoftheart skills in novel silk biopolymer design and silk analysis moreover the silk glue product will undergo intellectual property evaluations with seib further augmenting my professional skill set with this essential process and the potentials beyond gemsilk will also be assessedduring gemsilk i will gain substantial and rigorous training in silk analysis and essential assays for silks based healthcare i will be located at fraunhoferimes new worldclass multidisciplinary applied insect biotechnology research institute over the past months seib and i have honed gemsilk combining seibs profound experience in silk analysis for healthcare with my skills in silkworm genetic engineering not only promises to elevate my career through advanced training and project management but also to develop a gamechanging silkbased product for biomedical applications
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tablet games for early detection and intervention of developmental dyscalculia
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the ultimate goal of the project is to provide a screening and rehabilitation method for the early detection and treatment of developmental dyscalculia dd in the form of an entertaining tabletbased gaming environment dd is a common learning disability and severely impacts personal and professional development throughout the lifespan early diagnosis and interventions increase the possibilities for people with dd to live an independent and productive life children with dd have difficulties to map numbers representation into space in contrast typically developing children understanding of numerical concepts is facilitated by spatial mapping of numbers we want to develop a tool which will use a gaming environment to evaluate and stimulate space number association sna in children kids will be stimulated with gamelike sna tasks and monitored with more general mathematical skills tasks we will link the device with an online algorithm for online extraction of the responses that can compute and analyse each kids performance to track it as it changes over time this project builds on two behavioural tasks i have established to implicitly assess sna in children and infants these paradigms can become a firststage screening tool for individuals at highrisk for dd we will further advance this method into a tool that allows easy rapid and automatic testing of spacetonumber processing in young children from any cultural and educational background and in any context the paradigms will be embedded in a gaming environment which is optimally engaging for the young users facilitating the spontaneous participation in foundational numerical training targeted to the needs and specific numerical competences of each child moreover we will further validate relationship between sna and core numerical competence development providing initial crucial steps for empirical validation of our method as an early screening tool for dd
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trust and privacy preserving computing platform for crossborder federation of data
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as we live in a datadriven era the emergence of interdisciplinary geographically dispersed data repositories is inevitable the fact that these repositories do not necessarily abide with existing interdisciplinary data representation standards nor do they necessarily belong to any data federation initiative renders them unusable since researchers cannot easily access this data moreover most of the times integrity privacy and security in such interactions is either very difficult or impossible to maintain towards this end trustee aims to bring a green secure trustworthy and privacyaware framework that will aggregate various interdisciplinary data repositories such as healthcare education energy space automotive crossborder etc and also consider other european data federation spaces and transnational initiatives such as gaiax and eosc trustee will offer a securebydesign framework wherein stored data is homomorphically encrypted thus offering researchers i ability to search and use data in the encrypted domain ii a unified and meaningful fair representation of data in an open and fair manner iii complex and contextaware queries through advanced ontologies iv data processing and analysis through transparent trustworthy ml workflows over an intuitive ai playground which will promote ai explainability interoperability and reusability by utilizing state of the art methods and paradigms v compliance with european privacy and ethical frameworks eg gdpr pia etc vi enforce privacy by applying a homomorphic encryption layer through which all data interaction will take place vii a blockchainbased transaction recorder to ensure accountability trustees fully encrypted solution will be validated through six different use cases supporting gaiax eosc egi etc demonstrating a multidisciplinary paneuropean federated fair and private data ecosystem
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deciphering the role of the mycobacterium tuberculosis exometabolome in mycobacterial virulence
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mycobacterium tuberculosis mtb the causative agent of tuberculosis tb exhibits an intracellular lifestyle thriving within host macrophages this remarkable ability to evade macrophagemediated killing and withstand the challenges posed by the host environment hinges largely on its exceptional capacity to adapt its metabolism in response to the diverse conditions encountered during infection despite progress our comprehension of mtb metabolic adjustments in these circumstances remains limitedpreliminary investigations conducted within the host laboratory have unveiled that mtb releases a multitude of small soluble molecules into its extracellular milieu when cultured in vitro these metabolites potentially exert a substantial influence at the hostpathogen interface subsequently shaping the delicate equilibrium established between the bacterium and its host throughout the course of infection this proposal is centered on elucidating the role of mtb exometabolome at hostpathogen interface with the overarching objectives of i advancing our insight into mtb metabolism and ii pinpointing potential novel virulence determinants that might be secreted by the microorganismthe primary phase involves the comprehensive identification and quantification of metabolites present in the bacterial culture medium this will be achieved through untargeted metabolomics methodologies primarily utilizing nmr and mass spectrometry subsequently the metabolic pathways governing the biosynthesis and secretion of these metabolites will be characterized this investigation seeks to unravel the underlying metabolic drivers facilitating the release of these compounds the culmination of this project involves exploring the impact of a subset of significant metabolites on the physiology of infected macrophages as well as their role in modulating the immune response these assessments will encompass a spectrum of in vitro and in vivo strategies
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the map of redox intracellular signaling in skin physiology
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the skin is the widest organ of the human body despite this the mechanisms that underline its regulation are relatively poorly understood many skin diseases are characterized by defects in the control of lining renewal or reestablishing barrier integrity after the disruption thus dissecting the signals that underpin the maintenance of skin homeostasis and regeneration are of pivotal interest for medicine recently redox signaling as described to have a crucial role in these processes indeed h2o2 the major signaling molecule of redox biology is not only an essential second messenger involved in skin proliferative and survival pathways but also it is reported that mild er stress cursing with an increase in organelle redox potential is needed for efficient reepithelization recently we have shown the presence of different erlinked h2o2 fluxes that orchestrate cellular redox responses in normal conditions and after the induction of er stress in hela cell lines in this scenario i propose to unveil the compartmentspecific h2o2 fluxes that regulate the redoxstasis during keratinocytes differentiation with particular emphasis on those that arrive from the endoplasmic reticulum er indeed the er is one of the major contributors to cellular redoxstasis harboring sources internal regulators and distributors that vehicle redox signals back and forth to the er in particular i divide this project into two main aims i characterize the role of intracellular redox fluxes during keratinocytes differentiation both in 2d and in 3d models ii identify the interactors of erderived h2o2 flux in skin cell lines and characterize the downstream pathways importantly a systematic analysis of the timing thresholds and targets of redox signals in skin pathways is a paramount gap in the field that has not yet been tackled and thus constitutes the principal aim that this project wants to undertake
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climateresilient management for safe disinfected and nondisinfected water supply systems
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safe and affordable supply of drinking water dw in the eu under the pressure of climate change is a key priority despite longterm experience with the reliable operation of disinfected and nondisinfected drinking water supply systems dwss a number of challenges around microbial stability the future need for disinfection and the consequences of disinfection byproducts dbps formation for human health remain open directly deriving from climate change impacts such as increasing water temperature and higher levels of natural organic matter nomsafecrew aims to support the novel eu dw directive by generating advanced knowledge and developing tools and guidelines for disinfected and nondisinfected dwss and addresses improved comprehensive water quality characterization novel treatment solutions to actively respond to identified threats and the management of distribution networks to avoid water quality deterioration up to consumersnovel data sets on the occurrence and concentration of so far unknown dbps will be created and commercial actors stimulated to further develop tools for dbp quantification and mitigationtransferable tools will be provided to endusers water utilities nationaleu regulators researchers smes including i reliable methods to evaluate microbial stability characterise nom detect dbps and account for dbp human health toxicity ii protocols to select proper materials in contact with disinfected water iii monitoring and modelling tools also exploiting machine learning for realtime optimisation of dwss management and iv an integrated risk assessment framework to guide future interventions which ensure that both disinfected and nondisinfected dwss can continue providing safe dw in the face of climate changesafecrew will increase the preparedness of the eu water sector to challenges arising from climate change and will support the eus leading position in sciencebased policy making for dw consumer protection
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smart thermal metamaterials
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the main goal of this proposal to propose selfadaptive thermal regulation systems that are smart green aesthetically pleasing and engineering applicable is in line with the repowereu plan that efforts in saving energy and decarbonising heat in this project new thermal metamaterials are designed that integrates smart radiative cooling high solar reflectance and customized colour a multifunction design not previously available utilizing the metalinsulator transition of phase changing materials the thermal metamaterial adapts its thermal emissivity smartly to different ambient temperatures thus intelligently switching between on cooling mode in hot times and off cooling mode in cold times which benefits creating comfortable household conditions and contributing to energy saving from an allseason perspective besdies the thermal metamaterial can present vivid colours to satisfy aesthetic needs considering that thermally induced deformation can lead to structural failure of designed thermal metamaterials and affect their working life mechanical robustness is also considered for scalable production and for realworld applications a new inverse method is developed to accurately predict the structural deformation by eigenstrain reconstruction on basis of this mechanical stability strategy is proposed to eliminate the deformation which pushes the smart regulation system closer to realworld applicationthe proposed design is estimated to save at least 134 year for a single family in besançon franchecomt france the resulted energy savings not only bring economic benefits but also contribute to environmental preservation and climate change suppression by reducing greenhouse gas emissions this project can create significant impact in household energy saving and industrial heat management sectors
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open fan validation for carbonfree aircrafts
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the open fan concept has been around for decades its high propulsive efficiency combined with the elimination of the nacelle drag and weight has been always appealing to replace high bypass ratio ducted fans and reduce co2 and nox emissions the cs1 and cs2 programs have made relevant efforts to pursue the contrarotating open rotor cror concept as well though cror has not made it to market progress has been done reducing noise levels to that of ducted fansopen fans exhibit several differences with respect to ducted fans which by today are highly sophisticated components accumulating decades of research the chasm between the op concept and its product is too big to be covered by a single demonstrator since a wrong materialization of the idea can give rise to misleading conclusionsturbomachinery simulations have been perfected for decades and are essential to close the gap between the concept and the detailed implementation of the product however open rotors exacerbate existing problems eg bladetoblade variations even for small angles of attack strong coupling between co2 and noise emissions etc moreover open fans lack publicly available data or test cases preventing researchers from validating their ideas the first global assessment of cs2 reported an expected noise reduction of 9db in the innovative tp 130 pax project with respect to the last generation of ducted fans though at a lower flight mach number this project aims to obtain relevant noise and performance experimental data of an unducted single fan usf for the shortmediumrange aircraft with two objectives firstly confirm that about 510 db noise reduction is achievable at the expense of a slight penalty in fan efficiency and secondly validate and expand the scope of numerical tools an experimental database with the key results of the projects will be built to unlock the application of the usf for saf hydrogen and hybridelectric engine and aircraft configurations
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when communication fails investigating the effect of behavioural realism in customer care avatars on consumers emotions cognition and performance outcomes
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recent technological advancements have increased companies use of virtual humanlike characters with anthropomorphicappearances called avatars for customer care responding to the increased use of such humanlike customer care avatars cca thisproject aims to investigate how and under which circumstances ccas level of behavioural realism affects consumers emotions cognition and performance outcomes during consumercca communication with a particular focus on communication failure incidents utilizing qualitative and quantitative investigations particularly a systematic literature review and indepth interviews for qualitative investigation and a series of experimental studies for the quantitative investigation will be employed the project takes an interdisciplinary perspectiveby combining knowledge from marketing technology communication and psychology as such this research is expected tocontribute novel knowledge to the customertechnology interface literature which is an area that the marketing science institute hasidentified as one of the top research priorities for 2022 as experts estimate that the use of avatars will increase by 241 in thehospitality and by 187 in the consumer goods industry understanding customeravatar interfaces is of utmost importance withinthis research area moreover this project is proposed in response to the european unions declaration of funding research andinnovation that supports europes digital transformation with a new generation of technologies as one of the top priorities for20192024
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conserved and divergent mechanisms underlying cytokinesis in early vertebrate and invertebrate embryogenesis
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cell division is the fundamental process for cell differentiation and tissue formation in early embryogenesis mainly depending on the distribution and amount of yolk fertilized embryos undergo holoblastic and meroblastic divisions holoblastic division can be found in most mammalian embryos including mouse embryo in which actomyosin forms contractile cytoskeletal ring and divides the zygote into two daughter cells in contrast cell division in fish and insect embryos such as zebrafish and drosophila embryos are meroblastic and accumulating evidence shows that actomyosin is dispensable for meroblastic furrow ingression meanwhile microtubule has been suggested to constitute the main component that drive meroblastic furrow ingression how microtubule functions in furrow ingression of meroblastic cleavages in zebrafish and drosophila embryos and how far those functions are conserved between these species remain to be fully understood the miming project aims to uncover the role of microtubule and associated motor proteins in meroblastic furrow ingression in zebrafish and drosophila which fits me very well as i have abundant knowledge about functions of cytoskeleton in embryogenesis and biochemical experimental methods in checking the function of actomyosin and microtubules on the cortex of drosophila embryos in syncytial and cellularization stages from my phd study and followup work to check the biochemical and biomechanical mechanisms in meroblastic furrow ingression of zebrafish and drosophila embryos i would like to join prof carlphilipp heisenberg lab at the institute of science and technology austria ista prof heisenberg is a worldrenowned developmental biologist high citation publications 80 total citations 26670 who has pioneered interdisciplinary work at the interphase between developmental biology cell biology and biophysics using both zebrafish and ascidian embryos as model organisms
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the religious politics of theme parks in the 21st century imagineering religion heritage and national sentiments
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why do religious theme parks appear in secular countries makebelief investigates how in the 21th century immersive media are mobilized to imagineer religion the project provides a comparative analysis of religious theme parks in china turkey the netherlands and the united states makebelief investigates religious theme parks on three levels firstly this project analyses through documentary analysis why religious organizations heritage institutions government agencies and corporations in constitutionally secular countries came to design and use immersive media environments to orchestrate a public image of religion secondly by using participatory observation and media genealogy makebelief analyzes how immersive media forms eg animatronics 4d cinema reenactment the diorama but also the theme park as a genre are deployed in attempts to engineer peoples image of religion worldwide thirdly through ethnographic engagement with visitors and social media analysis it researches how audiences react to and reappropriate such attempts at imagineering religion makebelief offers four case studies a synthesizing and comparative work package and a visual anthropological work package to explore the dynamics of religion in the 21st centurythis way makebelief breaks ground in three areas 1 providing an academic framework that integrates the study of religion heritage and politics to better identify 21st century contestations for public meaning of religion 2 furthering the study of immersive media environments by researching its roles in religion heritage and nation 3 an improved understanding of how attempts to influence peoples perception of religion play out in the everyday lives of 21st century citizens makebeliefs findings will be of importance to those concerned with the future role of religion including policy makers religious communities and heritage institutions
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european researchers night 20222023 in malopolska
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european researchers night ern in malopolska has been organising in our region for 15 years and the night will be implemented in 2022 30th september and 2023 29th septempber for the 16th and 17th time the scope of the project will be further expanded beginning in 2022 thanks to researchers at schools activities we will introduce a series of scientific events throughout the school year all the project activities will be organized under the slogan researchers and the challenges of the modern world to present how researchers are working to tackle the challenges faced by our planet and the society these are the key areas defined as eu research and innovation missions and the objectives of the european green deal all the events will be held in the hybrid formula online and stationary activities to response the participants needs and current pandemic situation such formula enable to attract larger group of peoplethe main goal of the project are to bring science and the profession of researchers closer to the general public and make the public more aware of the impact of the work of researchers on our daily lives to develop interest in research and scientific careers in the youthscale of the project is huge to show the wide scientific heritage and achieve projects goals ern 20222023 ca 3 000 activities incl interactive workshops demos and experiments face to face meetings with researchers science shows etc ca 2 200 researchers emploeey and students as well as 110 scientifis circles from 30 institutions involved ca 90 000 people will participate in erns researchers at schools activities in 20222023 200 workshops demos and meetings with researchers 160 scientistsworkers and 80 students involved 20 000 pupils and 340 teachers from 280 polish schools will benefitthe project has european dimension due to its broad awareness campaign we estimate that 5 million people will be made aware of the project every year
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social kinships and cooperative care approaching relatedness in later prehistory through the analysis of women and children buried together
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skin social kinships and cooperative care explores relatedness beyond biological links in european copper and bronze age societies skin will analyse the nature of different relationships between coburied individuals in iberia and central europe c 30001000 bc it will adopt ethnographic archaeological and bioarchaeological approaches including adna and srisotope analysis to investigate to what extent kinship relations were based on genetic links or instead included constructs complementing and extending the nuclear family special attention will be paid to allomothering and cooperative care two practices extensively documented crossculturally but rarely investigated in prehistory skin will a contribute to developing an effective theoretical and rigorous methodological framework to investigate social kinship by reviewing bioarchaeological approaches currently in use b promote an alternative focus in archaeology moving from supraregional and longterm genetic issues to studying individuals especially women and children traditionally left behind c give new insights of kinship in prehistory based on both social and biological ties the applicants new skills in human osteology sr isotope and adna analyses acquired through highquality training at the host institution öai and during her mscapf secondment will contribute to achieving these goals collaboration on the ecrfunded project the value of mothers to society will create synergies exploring the gender dimension in europes later prehistory skin contributes to understanding kinship relations and the crucial role of cooperative care in the past which are current themes of worldwide order
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expanding the european ehrxf to share and effectively use health data within the ehds
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xshare envisions everyone sharing their health data in eehrxf with a clickofabutton the xshare button to be featured across health portals and patient apps and allow people to exercise their data portability rights under gdpr hence the european ehrxf will be the driver for research and innovation in ehds xshare will establish the european ehrxf standards and policy hub the hub partnership of six standards developing organizations centc251 hl7 europe ihe europe snomed cdisc ieee market actors digital europe medtecheurope and eucrof supported by competence centers nationals and regional authorities and european smes xshare will develop1 harmonized common specifications create and maintain xbundles ie collection of common data specifications including fhir implementation guides tools and data sets and educational support for key ehrxf health information domains as noted in the ehds draft regulation annex 12 a set of common elements across ehrxf health information domains applicable across ehds1 ja9 publicpopulation health ehds2 and clinical research3 extended harmonized ips specification to include care plans and making it fit for the purpose of clinical research use cases ie clinical trial eligibility real world data patient reported outcomes and returning clinical research data to patients4 xshare feature the xshare button in 8 adoption settings in hospital network italy national portal greece ireland cyprus regional network with emphasis in medical tourism and the connection of the public to the private sector catalunya and madeira entry of digital health applications to the myhealthspace ecosystem in france care plans will be demonstrated in denmarkxshare investigate the feasibility and value of the eu xshare industry label as a vehicle towards implementing the draft ehds regulation lastly open calls at the last year of the project aim to onboard with ehrxf almost 100 settings across europe
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overcoming resistance to immunotherapy immunostimulatory tumorderived extracellular vesicles as multifunctional anticancer agents
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tumor immunotherapy with immune checkpoint inhibitors ici has unprecedented therapeutic potential but its success is limited to a minority of patients with preexisting antitumor tcell immunity for patients with poorlyimmunogenic tumors combinatorial immunotherapies are urgently needed with a vast and bioactive cargo proteins lipids nucleic acids extracellular vesicles evs have intrinsic property to regulate complex pathways in distant target cells even though they can transfer tumor antigens which potentially activate t cells tumorderived evs tex have mainly been associated with immunosuppressive function i have recently identified innate immune pathways within tumor cells that regulate tex biogenesis and immunogenicity this allows for the first time to force tumor cells to release a defined immunostimulatory istex product the unconventional objective of immunotex is to generate a platform for the pioneering therapeutic use of tumorderived istex as multifunctional cellfree anticancer agents istex combine a cargo of a plethora of patientspecific tumor neo antigens and immunostimulatory constituents within a single nontoxic delivery vehicle that allows for efficient priming of tumor antigenspecific t cells the ability to harness the vast potential of istex is directly interwoven with a more detailed mechanistic understanding how tumorspecific cargo packaging in evs occurs and how they alter immune cell function therefore immunotex will identify and exploit the intracellular machinery in tumor cells for optimal istex generation investigate how istex enable an immunesupportive tumor microenvironment and validate istex to overcome ici resistance in relevant murine and human model systems hereby immunotex will eliminate current limitations of ici immunotherapy by rationally designed combination with istex to allow responsiveness in patients with poorly immunogenic tumors
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promoting gender parity and diversity at dioxycle
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dioxycle develops solutions to costefficiently capture and convert industrial co2 into sustainable fuel and chemicals by doing so dioxycle empowers industries to reduce their emissions in an economically viable way while offering sustainable alternatives to everyday commodities currently mainly produced from fossil resources such as carbon monoxide co chemical precursor ethylene c2h4 plastics precursor or ethanol c2h5oh fuel dioxycle is positioned as a technology and service provider and is focused on co2 emissions from hardtoabate sectors such as chemicals steel energy production and cement
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laser for magnesium the influence of laser wavelength and feedstock quality on the optical properties of mg alloy for industrial needs
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the overall aim of the project is to obtain the most optimum laser characteristics that will improve the ability to process mg alloys for laser based additive manufacturing method which currently suffers immensely due to excessive evaporation of the powder feedstock lasers are a form of monochromatic electromagnetic radiation that interact with each metal differently in selective laser melting slm process when laser energy is applied to the mg powder two primary processes occur absorption and reflectance the laser wavelength determines the degree of absorption in the metal powder due to low absorbance of traditional yttrium doped fiber laser in infrared range and low thermal conductivity mg processing requires using high power lasers that leads to rapid evaporation of mg when the laser hits the melt pool to accomplish these goals optical spectral absorbance properties of magnesium and its alloys in various forms plate block powder will be studied using uvvisnir spectroscopy effect of laser characteristics such as mode power and wavelength on the absorbance response and process stability will be characterized the impact of powder particle size distribution plate thickness surface quality alloy compositions on lasermaterial interaction will be studied the results will be used to obtain the highest success process windowthe project will create valuable knowledge for use in the field of slm of mg alloys the existing scientific gaps and technological challenges associated with laser treatment of mg alloys will be filled and sustained by commercialization by the researchers current employer the research plan is designed to solve an outstanding problem in the industry and will improve the long term employability of the researcher with his employer in europe the potential resulting technology will be a leap in the field of laser treatment of magnesium increasing industrial capacity in eu and stimulate further rdi efforts host name
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unlocking the potential of lohcs through the development of key sustainable and efficient systems for dehydrogenation
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by advancing breakthrough research on lohc technologies unlohcked aims at developing a radically disruptive versatile and scalable lohcdehydrogenation plant firstly highly active and stable catalysts without critical raw materials will be developed for reducing lohc dehydrogenation at moderate temperatures secondly an sofcsystem will be developed to be thermally integrated with the dehydrogenation process the heat demand of the dehydrogenation unit will be fully covered by the fuel cell while generating electric power the surplus of hydrogen is exported these innovative systems fully integrated will allow significant increase of overall efficiency 50 to hydrogen and electric power production from lohc three industry partners heraeus hygear and framatome will collaborate with four universities and research centres the university of bilbao spain cea cnrslyon and northwest university of south africa to develop scalable prototype system at trl 5 validating the performance of the technology during at least 500 h the ambition is to demonstrate the feasibility of a fully co2free dehydrogenation process for largescale production of hydrogen 1001000 t h2d and electricity with competitive prices hydrogen carrier delivery cost 25kg thus converting co2free lohc to electricity and hydrogen instead of using ng or lpg as heat source the unlohcked approach is clean circular it decreases energy consumption does not use noble metals while generating co2free hydrogen and electricitytechnoeconomic studies will demonstrate the potential of the technology to both supply hydrogen and renewable electricity to decarbonise the eu economy and to openup hydrogen transportation by lohc framatome hygear and heraeus will support the consortium preparing for fast market entry after the project
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heart attack monitoring patch hamp
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every year more than 60 million people live with cardiovascular disease cvd and more than 18 million people die as a result of cvd accounting for 36 of all deaths among different types of cvd heart attack and stroke are the leading cause of death in the eu the recognized guidelines identify the first one hour after the onset of a heart attack as the golden hour to receive proper medical assistance and prevent death or damage to organs hence there is a vital need for a compact and easytouse biosensing platform that can be used outside hospital settings by the patient or the ambulance staff for diagnosis of heart attack within the golden hour ntprobnp is a desirable biomarker due to its fast release kinetics higher circulation levels and lower fluctuations although significant advances in ntprobnp biosensors generations have been achieved these face some serious limitations as most of them cannot be used outside hospital settings requiring physical attendance of patients which leads to losing time beyond the golden hour and increased risk of death in this project i propose for the first time a wearable and wireless system for early and quick diagnosis of a heart attack outside the hospital setting the heart attack monitoring patch hamp that i propose here is composed of an ac electrokinetic acekbased fastresponse labelfree ntprobnp biosensor microneedles array for interstitial fluid sampling and data processing and wireless communication circuits although the acek phenomenon is a wellestablished method for the design of rapid biosensors this is for the first time that the acek effect is employed by a wearable biosensing system for high speed less than a minute and low lod below 1 pgml detection the hamp has a compact and conformal structure that is easy to use and can be used when patients feel the first symptoms of a heart attack and results can be conveniently sent to the nearby hospitals within the golden hour
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microwave squeezing with superconducting metamaterials
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the miss project targets transformative progress in the emerging field of distributed quantum sensing exploiting multimode microwave squeezing the final goal is to realise a robust and scalable technology for microwave squeezing and generation of nonclassical microwave radiation based on superconducting metamaterials the three specific objectives of the miss project are 1 technological innovation investigating new material and scalable microfabrication approaches to optimise the building blocks to produce travelling wave parametric amplifiersbased squeezers 2 metrology protocols developing dedicated cryogenic measurement protocols to accurately evaluate the radiation quantumness opening the way to standardisation 3 realisation of a prototype for real world applications developing a system with scalability potential for distributed quantum sensing in the microwave regime a usecase dedicated to multiparameter sensing for material characterisation will be targeted the outcomes of this project will pave the way towards real exploitation of quantumenhanced sensing techniques in the microwave regime the miss consortium brings together a unique set of expertise in design materials metrology fabrication cryogenic characterisation and commercialisation to be able to deliver on this ambitious goal
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a multiprocessor system on chip with inmemory neural processing unit
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deployment of intelligence at the edge presents many challenges because devices need to be lowcost and as such they are often constrained in computing capacity memory and energy resourcesthese constraints are not compatible with the need for much more advanced ai algorithms calling for mbytes of storage and tens of gops per inference and call for leaner edge ai algorithms the current state of the art for the few edgeai chips relies on lowcost process technologies at 90 or 40nm and in some cases up to 16nm with power efficiency between 15 topsw and power densities up to 1 topsmm2recently several industrial projects and a few products have started to surface pursing neuromorphic and in memory computing but none of these efforts have reached a level of maturity compatible with a mass volume production and cost and moreover the technology base they rely on is either not scalable to more advanced nodes flash or targeting ai computing algorithms whose practical applications are yet to be fully proven eg spiking the neurosoc approach instead is to rely on a solid mature and qualified reliable phase change memory technology to create an industrially proven path to go past the state of the art as such the neurosoc chip preproduct demonstration of the technology will be the first of his kind worldwideneurosocs aim is to develop an advanced multiprocessor system on chip prototype in fdsoi 28nm cmos technology that tightly integrates an aimc imnpu unit a local digital processing subsystem and functional safe multiprocessor host subsystems based on an enhanced version of existing riscv microprocessor implementation while covering imnpu security aspects holistically to tackle the requirements of a wide set of edgeai applicationsthe project will leverage stmicroelectronicss unique highdensity embedded pcm cell process technology being the denser and only such technology qualified and mature for embedded use in the industry world
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integration and harmonization of logistics operations
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logistics industry is facing continuous and significant challenges during the recent years the trend is the adoption of intelligent services for increasing the performance of the provided systems and synchromodal operations transfers and deliveries can benefit from the use of novel business models that adopt the aforementioned intelligent services when the optimization of the use of shared resources is the core target and become the basis for the provision of a climate friendly infrastructure the goal of synchromodal operations and the integration of heterogeneous logistics services is the reduction of current transfers in order to reduce the carbon footprint while securing the uninterrupted deliveries and the resilience to any disruptive event trace targets to the aforementioned integration activities offering a universal platform with functionalities related to planning scheduling optimization and events management as well as the use of blockchain technology to facilitate the real time conclusion of smart contracts and financial operations thus becoming one of the first attempts to provide an intelligent cover upon the current logistics frameworks trace envisions real demonstrators in different european countries with different goals that start from transportations with the use of shared resources the disruptive events detection and rescheduling of transfers while concluding with the use of unmanned vehicles to automate the last mile deliveries trace also proposes new transfer corridors safe areas where unmanned vehicles can collect items towards the final destination and new virtual hubs trace will perform studies related to the barriers towards the new logistics era the new business opportunities the requirements for the legislation and regulatory frameworks and expose the benefits of the proposed approach in terms of the reduction for energy demand and emissions while limiting the operational costs for logistics stakeholders
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structure function and regulation of antimicrobial and virulent amyloids at highresolution
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selfassembly of proteins and peptides into amyloid fibrils produced across kingdoms of life is associated with antimicrobial activity microbial pathogenicity and a wide range of diseases the correlation of fibrillation and morphology to function is poorly understood and highresolution structural information and mechanistic models are lacking our lab pioneered the atomiclevel analysis of bacterial amyloids and eukaryotic functional fibrils involved in cytotoxicity biofilm structuring and antibacterial activity we revealed novel morphologies extending beyond canonical amyloid cross structures of tightly mated sheets to include for example cross fibrils composed on amphipathic helices in addition we exposed a unique lipidinduced cross secondary structure switch in fibrils of the same sequence here we investigate amyloid fibrils which serve as key virulence determinants in s aureus and pseudomonas acting as cytotoxins and in biofilm scaffolding and as antimicrobials produced across different species we will leverage the knowledge and expertise and newly emerging methods in electron light and force microscopy to understand how fibrillation propensity fibril morphology and structural switches are connected to function membrane interactions and toxicity mechanisms at high resolution the findings are expected to identify structural features that underlie the formation regulation and activity of these fibrils providing advantages in specific environments understanding these structurefunction relationships will help to clarify the link between amyloid formation and antimicrobial activity we will use the insights gained from these studies for the rational design of antimicrobial peptides and small molecules targeting virulent determinants towards potential applications in the management of infectious diseases our findings on functional amyloids can overall advance life material medical and environmental sciences
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development of costeffective process for phycoremediation of dairy wastewater and valorization of algal biomass for production of biofuel and biochemical a sustainable approach towards biorefinery
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currently dairy wastewater dw is seen as a major global problem difficult and expensive to treat and potentially very harmful to the environment as it contains high amounts of organic and inorganic content the current treatment methods physicochemical and conventional are energyintensive and dont sufficiently remove the nutrients but with the high amount that is produced worldwide 0210 l wastewater l of milk processed this is potentially a valuable resource that if utilized appropriately can provide highvalue green chemicals and biofuel therefore a new costeffective method for the treatment of dw along with the generation of valuable biomass needs to be developed in this context algalbb proposes the concept of biorefinery for the substantive treatment of dw via microalgae coupled with biodiesel and biosuccinic acid sa production these objectives will be pursued through 1 the designing of a microalgae consortia that can remediate dw to achieve a zerowaste process and generate lipidcarbohydraterich algal biomass 2 the green synthesis of magnetic nanocatalyst for developing a lowcost efficient method for insitu transesterification for wet algal biomass to produce biodiesel 3 development of multienzyme magnetic nanocatalyst for efficient enzymatic hydrolysis to recover fermentable sugars from algal biomass 4 immobilization of fermentative bacteria for fermentation of sugars into sa the interdisciplinary algalbb will apply cutting edge biology tools to complete the aforesaid objectives algalbb adopts a circular economy approach that directly addresses clean water clean energy actions established by the eu horizon work programme and will support the competitiveness of european biorefineries the acquisition of transferable skills through algalbb will increase my employability in industry and especially in academia allowing me to establish myself as an independent researcher and reach a professor position within 510 years
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research on indigenous data governance protocols a toolkit for working with indigenous knowledge
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data governance trends increasingly emphasize the need to open access to data despite growing concerns over data privacy control and surveillance indigenous peoples with different epistemological traditions for the use and sharing of culturally sensitive information add the additional concern of peoples ability to exert data sovereignty thus while interest grow on the documentation and use of indigenous knowledge current data governance trends do not align well with indigenous data rights and governance rules this is the case of data on indigenous peoples perceptions of climate change impacts collected under the licci project 771056liccierc2017cog while adhering to the highest eu ethical standards data collected under the licci project failed to address indigenous data governance to develop a set of tools to guide the management of indigenous knowledge and data in the open while adhering to indigenous data governance principles in this project i will conduct research on indigenous data governance protocols ridagop in partnership with organizations working on indigenous data governance issues ridagop will undertake four activities in 18 months i a literature review to document indigenous data governance protocols ii an assessment on requirements to operationalize indigenous data sovereignty in an open context iii the development and testing of features to operationalize indigenous data sovereignty and iv the dissemination of results ridagop will facilitate the configuration and use of indigenous data sovereignty protocols allowing knowledge holders to set granular terms of access and use of data and to track data usage ridagop has the potential to reframe how datasets concerning indigenous peoples are managed and how indigenous peoples are represented beyond indigenous data sovereignty ridagop innovation in tackling equity in data governance can be upscale to issues such as national statistics or health
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infrastructures of expulsion migrant deportation and policing in india
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the unfolding migrant crisis in afghanistan has once again turned the focus on neighbouring countries as key locations where eu policies seek to enhance migrant hosting capacity yet research on southsouth migration and regional modes of prevention detention and deportation of illegal migrants remains limited taking the case of india my project aims to contribute such knowledge by addressing a central paradox in migration regulation ie why despite the proliferation of increasingly stringent forms and modes of migrant policing do state anxieties regarding the detection and deportation of illegal migrants continue to thrive my projects original hypothesis is that this paradox stems from the contingent stitching together of social material and biometric forms of policing that involve a range of formal and informal actors spaces and processes in unpredictable ways in conceptualising the uneven intermeshing of social material and biometric policing as infrastructures of expulsion i will analyse how the variation in forms of deportation policing produces precarity for migrants whilst engendering governance challenges empirically located in delhi my project will achieve its goal through anthropological methods of ethnography participant observation and interviews that will document practices of deportation policing in a residential neighbourhood police station and detention centre and its impact on african and south asian migrants hosted in the leading max planck institute for social anthropology the project will aid my scientific and professional training specialisation in migration and governance and career growth as an independent researcher insights on the paradoxical complexity of contemporary security frameworks and their substantial human and institutional implications will be disseminated through conferences journals media and a policy brief that will inform accountable regional and international migration policy
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novel integrated approach for assembly analysis of intrinsically disordered proteins at high resolution
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protein aggregation hallmarks several neurodegenerative diseases including alzheimers and parkinsons in parkinsons aggregation of the intrinsically disordered protein idp alphasynuclein syn leads to its intracellular deposition into lewy bodies which causes neuronal dysfunction recently it was discovered that syn can undergo liquidliquid phase separation llps whereby a protein solution spontaneously separates into a dense and a dilute phase this process is initially reversible but the high concentrations of the dense phase strongly favor the aggregation of syn into amyloid fibrils structural characterization of the transient syn conformations during llps and amyloid formation is therefore crucial for understanding the disease pathology on the molecular level this project aims to develop a novel experimental concept for the highresolution conformational analysis of syn assembly and aggregation using scanning mutagenesis combined with cuttingedge highthroughput biophysical techniques and computational analysis the core idea is to apply multiple biophysical assays to quantify the effects of hundreds of syn mutations on the kinetics and thermodynamics of llps and amyloid formation the resulting multidimensional experimental datasets will be processed within the phivalue analysis framework originally derived for protein folding and combined with molecular dynamics simulations the integrated methodology will allow gaining important structural and mechanistic insights into the earlyaggregation events of syn at a single amino acid level of resolution the project includes extensive training to enhance my scientific skills in modern experimental and computational methods the proposed strategy is widely applicable to other idp systems that can undergo llps and aggregation and paves the way for the design of rational and precisely tailored intervention strategies against the diseases associated with these phenomena
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satellite processing by artificial intelligence enabling satellite analytics
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business need climate change leads to infrastructure disruption food insecurity and global losses and hence does directly affect safety and security of people nowadays when an event occurs emergency protocols are activated and damages are evaluated in the following days there is a need of having vulnerability assessment information before the event occurs to know where the most vulnerable area asset or population is knowing the most vulnerable point and its dynamic evolution where the impact will be worst is a key information to generate an adaptative answer to climate extreme events and minimize socio economic damageshowever current impact analysis methods are semiautomated limiting the speed coverage and number of analyses that can be done our solution interoperable fast to deploy and easy to use is based in the analysis of different data sources such as copernicus satellite data meteo patterns and opendatamarket opportunity during the last decade thousands of satellites have been put in orbit creating the new space economy the total amount of investment done just in copernicus satellites amounts to 82 billion in addition according to space capital the total equity investment over the last decade in the space economy was 1777 billion however the penetration over different industrial markets is very low putting at risk the return of investment roiearthpulse goal artificial intelligence ai is the transformational technique of our era satellite data and in particular earth observation eo will greatly benefit as other areas from its application by lowering the cost of adoption and accelerating market uptake our company goal is to accelerate the market uptake of eo data with aiat earthpulse we are working hard on overcoming these barriers with the objective to leverage the full potential of ai4eo to make satellite analytics accessible to anyone experts and nonexpert users through our software spai
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physics for all
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throughout the past decades cutting edge research in the frontiers of physics astrophysics gravitational waves particle physics astroparticle physics has provided us with major discoveries and applications and has launched impressive initiatives in the physics of the very big and the very small despite the dissemination effort aiming to inform both the public and the school community about these initiatives and their impact to society a gap exists between research and societyeducation which might help to spawn misconceptions about the content context and mission of science and thus lead citizens to fall prey to antiintellectual attitudes and stereotypes to this end physics for all pico aims to support all citizens to increase their awareness of fundamental cuttingedge physics and of the impact that discoveries in this field have on their everyday lives with a specific focus on equity diversity accessibility inclusion and gender equality with targeted activities focusing especially on students by bringing together major european research institutions in the fields of frontier physics and science education as well as partners with high expertise in communication media and marketing pico will forge sustained links between researchers and citizens and coordinate researchers night and researchers at schools activities in 2024 and 2025 in 4 countries greece italy france spain aiming to engage more than 40000 citizens and inspire more than 2000 students in science and attract them to scientific careers
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particle emissions air quality and climate impact related to fuel composition and engine cycle
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among aviations nonco2 impacts the largest radiative forcing value is attributed to contrail cirrus recent tests have revealed an opportunity for lowering soot particles emissions and ice crystals which play a pivotal role in contrail properties through the use of saf however substantial disparities remain among those test campaigns involving a large variety of fuels engine types and combustors it is therefore not straightforward to compare and reconcile resultsin this context pacific aims to bridge the gap the project will test an unprecedented set of fuels from lab up to engineaircraft level with a similarity of hardware and combustion parameters it will translate the results into modelling efforts to better correlate i soot formation based on an improved yield soot index database and prediction model ii particle emissions depending on fuel composition for the whole engine thrust range via an upgraded groundtoflight correlation methodology iii the ice forming potential of engine emissions using advanced measurement methods on ground iv the nonco2 emission mitigation potential through the impact assessment of fuel composition and engine cycle on contrail properties and radiative forcing and longerterm climate impacts including co2 emissions fuel production this will allow to consolidate the costbenefit assessment of various fuel options and provide valuable inputs to potential future fuelrelated measuresby doing so pacific will pave the way for future fuel specifications minimizing the climate and local air quality impacts and will provide important inputs to future modelling and testing workpacific leverages on 11 partners from 4 countries bringing together a unique combination of engineaircraft manufacturers fuel producers research and academic expertise at the forefront of sustainable aviation collectively driving advancements to help strengthening the european aeronautics leadership position
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gateteleported gaussian boson sampling
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quantum computation holds promise for enormous advancements in humans computational power among various possible approaches quantum computation in the optical continuousvariable cv platform offers roomtemperature compatibility and unprecedented potential for scalability into millions of entangled modes however the platform needs to demonstrate its power in practical applications and in encoding qubits that are compatible with faulttolerant computational architectures here i propose the gtgbs project which paves the way for addressing these challenges by realising the gaussian boson sampling gbs protocol to leverage the computational power of the platform the major improvement of the gtgbs project is that it will use the gate teleportation technique in cv quantum optics to replace the large interferometer array in the current realisations of gbs with a simple measurementfeedforward structure the gtgbs project is expected to overcome the effect of photon losses in the interferometer that has a significant detrimental effect on the scalability of gbs experiments meanwhile it has excellent compatibility with the measurementbased quantum computation architecture a promising technical route to realise faulttolerant quantum computation in the cv optical platformthe gtgbs project has a high potential impact by improving the performance of the gbs experiments the developed setup will acquire the computational power to solve practical interdisciplinary problems like combinatorial optimisation and drug design furthermore the setup can serve as a resource state preparator for faulttolerant cv quantum computation it is thus plausible that the gtgbs project will make a solid contribution to the development of quantum technology and provide several practical applications in industry
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centre for data enriched medicine teampermed
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using advanced experience medical research progress and international knowhow the teampermed project empowers the university of tartu together with tartu university hospital to form the independent centre for personalised medicine teampermed this center of excellence coe will become a multidisciplinary unit integrating expertise in genomics it clinical medicine and socioeconomic analysis it will create a scalable framework for developing clinical guidelines and clinical decision support cds tools that can be effectively integrated into eu healthcare systems with the guidance from the leading expert partners erasmus medical centre and the university of helsinki a vibrant network of associated stakeholders and the support of ec and the republic of estonia teampermed will become a recognized regionaleu leader in translating genomic and electronic health data to prevent the development of chronic or hereditary disease and offering highquality personalized medical care teampermed will stimulate digital transformation in healthcare by using available databases and electronic health records to develop ai tools and protocols effective for preventionearly identification of individual health risks and their consecutive treatment teampermed coe intellectual outputs including technology tools knowledge and innovative healthcare practices will boost estonias and europes competitiveness in the emerging personalised medicine sector improving the quality of healthcare prolonging longevity and maximizing health of european citizens and bringing the advantages of future digital medicine to our citizens already today the teampermed center will become an internationally recognized leader in the areas of personalized medicine and customized healthcare contributing directly to a better physical and mental wellbeing and indirectly to social and spiritual wellness opening the door to a more harmonious society and paving the way for the next generation
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understanding and alleviating inequalities in digital news consumption
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this projects vision is to understand and develop strategies to mitigate inequalities in digital news consumption the acquisition of political knowledge and vulnerability to misinformation while inequalities in digital news access have been lowered with very high levels of internet access in many countries there are indications that inequalities in digital news use and the benefits of being exposed to it like the acquisition of political knowledge are increasing academic literature has been instrumental in describing how digital intermediaries eg social media or search engines and different modes mobile devices have changed the way people consume news however little attention has been given to how these changes manifest against the backdrop of preexisting social inequalities in news use and the acquisition of political information thus the project will a reliably identify digital inequalities in news use the acquisition of political knowledge and vulnerability in online misinformation in countries of the global north and the global south in its examination it will focus on b longstanding informational inequalities related to social class gender and age and c the role of new information technologies like digital intermediaries and mobile devices apart from identifying people with low levels of news use this project will d explore the ways that parts of the population navigate and face disadvantages in a complex digital media environment last this project will for the first time e test digital public health style interventions that could reduce inequalities in digital news use political knowledge and exposure to as well as belief in online misinformation to achieve these objectives this project will employ a novel set of methods overall this project will be the first to examine and to find ways to alleviate inequalities in digital news use using a holistic mixedmethods approach in a global northsouth comparative framework
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next generation quasiadiabatic propagator path integral quapi methods for condensed phase quantum dynamics
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the inevitable interaction of a quantum system with the environment leads to energy relaxation and decoherence which can result in novel phenomena and opportunities not present in isolated quantum systems of particular interest is the nonequilibrium relaxation dynamics subject to nonmarkovian memory and at strong interaction with the environment in such situations novel and generally applicable computational methods are necessary for precise and reliable simulations of the many body dynamics of open quantum systems for this purpose a hierarchy of methodological developments is proposed within the framework of the quasiadiabatic propagator path integral quapi method that address i the generalization of the method to more complex environments ii its numerical efficiency and scalability and iii employ neural networks to leverage algorithm performance finally iv a quantum algorithmbased strategy is pursued for accelerated numerical propagation algorithms on nearterm quantum devices the hierarchy of developments facilitates simulations of condensed phase quantum dynamics for more complex systems and ever complex environments to address highest relevance open questions and research objectives in the understanding of condensed phase quantum dynamics specifically if the interactions of a system with its environment potentially can affect the systems coherence the underlying mechanisms leading to complex many body phenomena and the possibility of control of the system dynamics and its decoherence ultimately the algorithm developments and novel conceptual approaches will yield a comprehensive numerical path integration software platform for condensed phase quantum dynamics simulations that has groundbreaking potential by facilitating extremely challenging simulations that are not yet possible on classical computers or only envisioned on tailor made quantum devices
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improving plant immunity by synthetic exploitation of the ubiquitin system
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plants are continuously attacked by pathogens and pests resulting globally in large agricultural losses and food insecurity at high economic cost to counter infection plants have developed sophisticated immune responses in which the posttranslational modifier ubiquitin plays indispensable roles ubiquitination is a versatile protein modification that regulates the amplitude and intensity of immune responses thereby establishing durable resistance substrate ubiquitination is performed by e3 ligases that act as matchmakers by recruiting specific substrates despite the essential roles of e3 ligases in plant immunity it remains unclear how they achieve such extraordinary substrate selectivity and how they evolved to adapt to changing threats in their environment including new pathogens conversely pathogens have evolved effector proteins that hijack ubiquitin signalling to prevent immune activation but the underpinning molecular mechanisms remain obscurethe synubl project will establish interactions between the major cereal crop barley and fungal pathogen puccinia hordei as an economically relevant hostpathogen system for addressing these questions and to bioengineer durable resistance by functionally tracking immuneinduced e3 ligases along the evolutionary tree we will reveal how these enzymes evolved structural features for specific substrate recognition simultaneously we will expose p hordeis hijacking tactics thereby uncovering the significance of ubiquitin in shaping the evolutionary arms race between host and pathogen collective insights are then utilised to synthetically engineer novel e3 ligases to allow ondemand activation of host immune pathways and ondemand destruction of immunesuppressing pathogen effectors hence this project not only provides fundamental discoveries in ubiquitin signalling it exploits these innovations by generating sustainable strategies for durable crop resistance in the agrifood sector
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quantum fluidsoflight turbulence in semiconductor microcavities
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quantum fluids are an extraordinary category of physical systems where quantum nature reveal itself at a macroscopic level superconductivity superfluidity and boseeinstein condensation are spectacular examples of macroscopic coherence effects in quantum fluids driven outofequilibrium both classical and quantum fluids display turbulent behaviors the main difference between the two is lying in the fact that quantum fluids possess an absence of viscosity and the building blocks of turbulence phenomena the elementary excitations named vortices have to be quantized meaning that the phase circulation around their core has to be a multiple of 2pi these two properties affect drastically the systems behaviors compared to the classical turbulent scenario where vortices are known to interact all together in a continuous manner and have the potential to redistribute the energy of the system at all scales these brought the questions of how vortices are nucleating interacting and recombining in the quantum fluid opening the field of quantum turbulence how the primordial fluctuations associated with the quantum nature of the system can influence the aforementioned vortex properties is their spreading of entanglement mediated by interactions in a turbulent superfluid leading to squeezing states having insights into the previous questions would allow to understand what is the main implication of the difference between quantum turbulence and classical turbulencein this action we propose to investigate these questions with a superfluid of light made of semiconductor microcavities this system allows to realize full microscopic investigation of 2d vortex spatial distributions to unveil their statistics and their interactingnucleating properties furthermore by elaborating a new time sampling nonlinear detection we will evaluate spatiotemporal correlations spreading in the system with the potential to enter the deep quantum regime of quantum fluids
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algbio co2 capture from flue gas and phycoremediation of wastewater via microalgae for carbon negative biofuelsbioplastic production with the circular economy model
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the level of co2 in the atmosphere increased two times compared to the preindustrial period the biggest reasons for this are the flue gases of the factories and greenhouse gas emissions in transportation billion tons of industrial wastewater and co2 from the same factories continue to destroy our biodiversity in sealakesrivers because of mucilage eutrophication ocean acidification and deoxygenationwith global production sectors responsible for onefifth of carbon emissions consuming 54 of the worlds energy sources there is an urgent need for manufacturing companies to minimize co2 emissions and optimize energy consumption algbio provides production facilities and industry with a circular economy model service where they can capture their carbon purify their waste and produce their energies and raw materialsalgbio will help the industry lower the environmental impact of the wastewater and flue gasses while turning the waste into energy with its circular economy model and patentpending technologyalgbios bioremediation technology is called phycoremediation which can be defined as the use of microalgae for the removal or biotransformation of pollutants including nutrients and xenobiotics from wastewater and co2 from waste air rubisco enzyme activities of algbios metabolic engineering algae species have been increased in this way algbio realizes carbon capture more efficiently and costeffectively with advanced phycoremediation algbio can remove up to 95 of biological oxygen demand chemical oxygen demand nitrogen phosphorus and conductivity from industrial wastewater and sewage compared to an unefficient carbonpositive conventional bacterial treatment the successful completion of the algbio project will enable us to identify the pilot customers and implement our solution algbio photobioreactors and algbio biofuel production reactor after the project completion
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holographic extended reality hxr for true augmented reality ar and lifelike immersive displays
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lifelike 3d images holograms have the potential to revolutionize key sectors such as manufacturing healthcare consumer electronics and creative industries however it has not yet been possible to create usable holographic displays for commercial applications due to the low visual quality of digital holograms and the very limited field of view of holographic projections swave is developing hxr the worlds first spatial light modulator specifically designed for digital holography our proprietary technology will be commercialized as a novel chipset with supporting systems and algorithms capable of generating and displaying highfidelity dynamic holographic imagery hxr will enable display manufacturers to create immersive ultrahigh resolution holographic displays disrupting visualization markets forecast to grow to 100bn by 2030 swave is a spinoff from imec leveraging 12 years of research and a team with 100 years of experience in bringing semiconductorimaging products to market
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intimate dispossession the afterlives of plundered jewish personal possessions in the aftermath of the holocaust
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this project aims to write the history of the great plunder of small thingseveryday household objects and personal items including clothing looted on a massscale by local nonjews during and in the aftermath of the holocaust while historical research has focused on the topdown and centralized nazi states takeover of jewish financial assets real estate businesses or art objects we know nothing about the afterlives of unmarked objects of daily use that changed hands in the course of the holocaust and continued being used for decades in the small local communities of eastcentral europe the main objectives of the project are to document different modes of how jewish personal possessions were appropriated by nonjewish local populations of eastcentral european shtetls examine how they have been redeployed adapted and misused by their new owners and assess the social and psychological transgenerational impact of this kind of plunder on the communities of both the beneficiaries and the victims breaking with the topdown view on holocaust dispossession this project focuses on eight microstudies of communities located in three different administrative units of germanoccupied eastcentral europe plundered lives novelty is in a combination of a microhistorical analysis with qualitative approaches of social studies and social psychology extending the typical time frame 19391945 to include dispossession practices that continued after wwii and experimental outreach strategies of digital crowdsourcing curatorial interventions in public spaces and crossgenerational interviewing to elicit responses from the implicated communities and document hitherto inaccessible material in private possession highly interdisciplinary plundered lives will open avenues for future research into the fields of genocide studies anthropology of conflict social psychology economic history and forensic studies
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a proactive approach to the recovery and recycling of photovoltaic modules
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current recycling practices for photovoltaic pv waste modules are unrefined and recover low volume and low value materials to be economical and sustainable the recycling of pv waste needs to efficiently recover all of the material constituents at a quality suitable for the reuse in new pvs with minimal impact apollo will create a circular approach to link legacy recycling future production and future recycling a pilot line will be demonstrated and used to process an input of 40 tonnes of pv waste which will be recycled resulting in enough reclaimed materials for 1 tonne of remanufactured silicon and 30 exemplar pv modules incoming modules will be streamed by glass composition enabling batch recovery of highquality glass to be used for new solargrade glass a novel continuous sonification technique ultrasonically excited etchant will rapidly separate silicon silver copper and other metals in a sequence along a pipebased process used liquid etchants will be recycled in a closed loop resulting in low waste small footprint further recovered silicon will be refined to a purity suitable for new pvgrade ingot growth the objective is to deliver purified silicon with a minimum purity of 999999 multiple innovations increase the percentage weight recovery from 18 to 93 apollo will prove the suitability of the recycled silicon by growing new ingots manufacturing solar cells and then new pv modules 20 percbased modules 10 tandem modules and 30sqm of single junction perovskite cells will be made these modules will incorporate new designs materials and manufacturing methods and be designed for disassembly and recycling blockchainbased digital product passports dpps for pv will be designed and implemented as well as an online marketplace for reused remanufactured andor recycled pv components dpps provide secure and trustworthy data for the life of the product and aid recycling by supplying material hazards and history on request
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quantum vortex simulator from fundamental properties toward engineering mobility
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vortices lie at the heart of classical fluid dynamics in both nature and technology likewise vortices play an essential role in quantum fluids and solids determining their fundamental transport properties this project will explore both fundamental and practical aspects of quantum vortices at a new level using the platform of quantum gases expanding the horizons of vortex research it aims at experimentally addressing intractable vortex problems by taking the best advantage of the latest quantum technologies and the favorable time and length scales of vortex dynamics in ultracold atomic superfluids first i will explore both twodimensional 2d and threedimensional 3d vortex dynamics in a homogeneous box potential with an emphasis on the universal characteristics of vortex dynamics on macroscopic length scales changing the vortex length inside a uniform trap will allow us to cross freely from 2d to 3d vortex physics second i will study vortex dynamics in sophisticatedly tailored pinning landscapes the unprecedented controllability of these arbitrary pinning potentials and vortex configurations will enable us to shed new light on many elementary aspects of vortex dynamics paving the way for engineering vortex mobility and thus directly impacting superconductor research
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quantum information processing with interacting parties
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we are approaching an era where the capabilities of quantum hardware begin to meet the requirements of theoretical quantum protocols such times give new urgency to the central challenge of the theory of quantum information processingfor which tasks do quantum devices hold an advantage over their conventional counterpartsmy proposal addresses this challenge in the context of information processing with interacting parties which is the natural setting for problems in cryptography communication and distributed computing we take a twopronged approach with each prong addressing an essential facet of interactive information processing while sharing a common focus on efficiency a desired impact is to kickstart a new pragmatic trend that focuses on efficiency in areas where the main goal so far has been an informationtheoretic understanding of ultimate quantum capabilitiesthe first work package deals with the uniquely quantum resource of entanglement which is responsible for most quantum advantages in multiparty settings we will propose new tools eg entanglementpreserving reductions that will allow us to systematically identify scenarios where the generally elusive quantum advantages can be detected and realized efficiently we will also address major outstanding challenges like the parallel repetition question and finding a simple task capable of distinguishing two competing models of entanglement the latter is our most ambitious goal which would provide an alternative proof for connes embedding problem and lay theory groundwork for an experiment capable of identifying the right mathematical description of realitythe second work package will leverage schurweyl duality to devise efficient algorithms for symmetric problems with quantum input we will put forth new error reduction algorithms for blackbox devices eg quantum majority vote and propose highly efficient explicit quantum circuits for key subroutines like quantum schur sampling
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volatile evolution on terrestrial planets
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volatile elements such as water carbon and nitrogen with low condensation temperatures are needed to achieve and sustain habitable conditions they also regulate planets geodynamics and climate evolution however how these volatiles were delivered to terrestrial planets and how they subsequently evolved is actively debated due to their inertness and high volatility the noble gases krypton and xenon are unique geochemical tracers of volatiles their nonradiogenic isotopes have kept the signatures of the sources that delivered volatiles to planets and of the evolutionary processes subsequent to accretion like recycling via subduction yet the nonradiogenic krypton and xenon isotopes have barely been used in particular for krypton due to major analytical challengeshere i propose to develop an original geochemical tool the nonradiogenic krypton and xenon isotopes i will develop innovative analytical protocols to allow high precision measurements of these isotopes the objectives are to determine the sources of volatiles for terrestrial planets and to assess when volatiles started being recycled into the earths mantle via subduction to achieve these goals i will i determine the precise krypton and xenon compositions of different types of meteorites to evaluate whether one meteorite type can explain the signature of the earths and mars mantles ii assess the volatile sources of the martian mantle by studying the krypton and xenon compositions of the martian meteorites shergottites and nakhlites iii determine the krypton and xenon compositions of different earths mantle sources from the presentday to the archean by analyzing midocean ridge basalts and granitoids the analyses on granitoids will be combined with highpressure hightemperature experiments to study the krypton and xenon elemental fractionation processes which will be key to providing a global understanding of the measured fluid compositions in granitoids
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mutations of mtdna inheriting without perishing
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mutations of mtdna cause mitochondrial diseases and are heavily implicated in the pathophysiology of ageassociated diseases and ageing low levels of mtdna mutations are universally present in somatic tissues of all humans and mtdna mutations have been reported to contribute to ageassociated diseases somatic mutations of mtdna often arise during the massive mtdna replication in embryogenesis and can accumulate postnatally by clonal expansion furthermore ongoing mtdna replication during adult life also contributes to the burden of mtdna mutations in mammalian somatic tissues mammalian mtdna is maternally transmitted without germline recombination and this asexual mode of transmission should theoretically lead to a mutational meltdown over generations the socalled muller ratchet at least two poorly understood mechanisms in the maternal germline counteract the transmission of mutated mtdna from mother to offspring ie the bottleneck mechanism and purifying selection the bottleneck mechanism ensures that only a fraction of the pool of mtdna variation in the mother is transmitted to the offspring the purifying selection functionally tests mtdna and decreases transmission of mutations in this proposal we will use powerful mouse models and completely new experimental strategies to study how mammalian mtdna mutations are inherited and how somatic mtdna mutations contribute to ageassociated disease and ageing maternally inherited pathogenic mtdna mutations often cause lifethreatening incurable diseases with failure of multiple organs in humans unfortunately the principles for inheritance of pathogenic mtdna mutations are often unclear and the knowledge generated in this proposal will give a better basis for genetic counselling furthermore the mechanisms counteracting a mutational meltdown of the nonrecombining maternally transmitted mtdna is a central question in biology of great basic scientific interest
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design of novel magnetic graphene oxide nanozyme platform for theranostic applications
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maggraphzyme aims at the development of a new hybrid multiplatform capable of triggering the intracellular production of reactive oxygennitrogen species rosrns for inducing cell death in cancer cells the proposed hybrid nanosystem based on the combination of magnetic nanoparticles mnps nitrogen doped graphene oxide ngo and a polymer plga shell will improve rosrns production due to the synergistic effects of all components regarding their catalytic activity as peroxidasemimetic nanozymes the control of this catalytic activity will be performed by heating the intracellular level via the activation of the constituent mnps through a remotely applied magnetic field thus a novel approach for intracellular rosrns production and quantification will be implemented furthermore with the aim of understanding the different cells pathways involved in the toxicity and the final death of the cells these hybrid system will be evaluated to investigate pathwayspecific rosrns induction of apoptosis and rosresponse mechanisms thus i will study signaling pathways which are known to be influenced by the production of these species to this end i propose detailed physical and chemical studies down to the atomic level of the mnpsngoplga systems for identifying the relationships between catalytic efficacy and active atomic sites within the structures these works will be developed by a motivated researcher with a strong background in mnps who will enhance and diversify his skills in advanced microscopy techniques and will acquire competences in biomedicine this multidisciplinary and innovative proposal will strengthen the collaboration between the hosting institutions will enable the european hosting institution to reinforce crucial competences in the understanding production of multifunctional materials and will contribute to improving oncological applications which is one of the most important scientific challenges with a high social impact
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novel electrode coatings and interconnect for sustainable and reusable soec
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the nouveau project will develop solid oxide cells socs with innovative la and pmgfree electrode materials solid electrolyte and interconnects with an overall reduced amount of ree 30 recycled y 5070 and cr 20 to this end advanced coating methodologies and modelling will be employed in combination with sustainablebydesign and recycling approaches integrated models will be adapted and developed to predict physicochemical propertiestoxicity endpoints in real life scenarios including multiscale models databased modelling shf spf userready modelling for industrial deployment ssbd tools standardisation and regulatory compliance reach updatesby addressing resource and energy efficiency through material design and waste management nouveau will create opportunities for increased circularity of raw materials lower climate impact and decreased criticality of solid oxide cells materialsto validate the nouveau projects objectives and their economic commercial and environmental impact a comprehensive set of assessment techniques will be used including lifecycle analysis cost analysis and social and ecoefficiency lifecycle analysis the assessment results will guide the projects efforts towards optimised resource efficiency and soc upscaling with improved stability benchmarked against the reference stateofthe ones more specifically nouveau will benefit from the complementarity and scalability of the green inks development in combination with spray printing slot die coating and convection and radiation drying the nouveau project draws on the complementary expertise of applied research centres and innovation driven companies including marion technologies coatema fiaxell and qsar lab in the field of materials design soc engineering and multiscale modelling including in silico methodologies machine learning artificial intelligence
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secure decentralised intelligent data marketplace
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the eu data economy has grown tremendously with forecasts predicting to reach 800billion euros in 2025 data are becoming the new currency being exchanged as products or services in marketplaces data markets are predicted to reach a size of 100billion euros in 2025 existing data marketplaces are centralised store the data on the cloud provide limited to no guarantees about data quality and they are governed by single entities that make the rules sedimark merges the expertise of a large team of experts to build a secure trusted and intelligent decentralised data and services marketplace based on distributed ledger technology and artificial intelligence sedimark enables distributed heterogeneous data within the eu to be easily and seamlessly linked shared and exploited for diverse business and research scenarios sedimark builds upon the concept of fair data ensuring that data are of the highest quality unbiased enriched and annotated so that they can be discovered accessed and easily reused sedimark includes a distributed registry of resources dataservices stored on edge systems close to where they are generated and where the data are cleaned labelled validated and anonymised security is applied with strong access control privacy techniques for data minimisation and purpose limitation exploiting blockchain for enforcing trust decentralised identities and data verification energy efficient ai techniques will be used for automated data quality management labelling and classification of data as well as for providing distributed analytics and advanced services on top of the data semantic interoperability based on common ontologies and data models will allow the easy and efficient discovery sharing and federation of heterogeneous data from multiple sources the system is built on top of existing platforms of the consortium starting from trl5 and will be tested and demonstrated in four real world scenarios reaching trl8
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a new paradigm for highprecision top mass and jet substructure measurements at the lhc
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we are in the era of precision collider physics where a major challenge is to accurately describe the effects of the strong interactions the precise determination of the top quark mass is one of the most important measurements in particle physics it is crucial for indirect searches for new physics and the analysis of the stability of the universe currently the measurement is plagued by theoretical imprecision including an overreliance on monte carlo simulations and the lack of a systematically improvable treatment of the physics of hadronization the process by which quarks and gluons are bound into colorneutral hadrons the same limitations also impact essentially all jet substructure measurements this includes measurements of the strong coupling which is another fundamental parameter of the standard model with the highluminosity phase of the large hadron collider lhc on the horizon addressing these problems becomes exceptionally timely and criticaltopmass will overcome these problems by 1 capitalizing on the pis recent groundbreaking work to exploit energyenergy correlators as a top masssensitive probe leading to a new paradigm and 2 exploiting modern effective field theory methods for developing a modelindependent framework to describe hadronization enabling precise jet substructure determination of the top mass and the strong coupling this avoids the systematic uncertainty from the usage of hadronization models it will have immediate applicability to a wide range of precision qcd measurementsthe key outcomes of topmass will be1 highprecision computations that enable a subgev top mass measurement at the lhc in a fieldtheoretic scheme2 a systematic datadriven approach for describing hadronization effects in modern jet substructure observables
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comprehensive search for new phenomena in the dilepton spectrum at the lhc
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while the standard model of particle physics sm has proven tremendously successful experimental evidence points to it not being a complete description of our universe but a low energy approximation of a more complete theory the searches for new phenomena np are therefore an important component of the experimental program of the large hadron collider lhc while there is no direct evidence for np at the lhc measurements of beauty hadron decays display a seemingly coherent pattern of deviations with respect to the sm predictions which suggest that np couples differently to three generations of matter the quarklevel processes responsible for these socalled flavor anomalies are related to dilepton production processes drellyan scattering through the crossing symmetry the measurements of the kinematics of the high mass drellyan hmdy process are therefore uniquely sensitive to a wide variety of np explanations of the anomalies the goal of this groundbreaking project is to provide for the first time the complete set of worlds most precise hmdy differential crosssection measurements covering not only the light lepton channels evvee but also extremely challenging third generation v and ditau ditto final states these measurements will be used to probe np at mass scales beyond the reach of direct production at the lhc through the sm effective field theory framework the innovative performance and trigger improvements of the ditto project will allow the ensemble of the proposed measurements to reach maximum precision boosting the possibility for a np discovery within the data sets expected to be collected by the atlas experiment at the lhc just as dilepton resonances such as the j and y mesons and the z and w bosons were crucial for the establishment of the sm the study of the same final state to be undertaken in the ditto project will help to pave the way for a better understanding of the physics processes beyond it
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between canon and coincidence using datadriven approaches to understand art worlds
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the becaco project applies a novel multidisciplinary framework to studying the provenance of ethnographic and archaeological collections moving away from the current focus in provenance research on single objects collectors or institutions the aim of the project is to reconceptualize provenance as the largescale study of the sociopoliticohistorical conjunctures that led to the translocation of cultural material to do so it introduces the concept of art world patterns an expansion and reframing of the idea of art worlds becker 20081982these patterns will be identified through an innovative combination of various datadriven methodologies by applying quantitative analyses network analysis and data mining on a large corpus of provenance data the project will explore the promises and limitations of different datadriven approaches in the context of largescale ethnographicarchaeological provenance research through this process the project will devise new models for provenance research in ethnographic and archaeological museumsthese conceptual and methodological advances will be mobilized through the study of indigenous latin american material from 12 museums in 9 countries the project will create a groundbreaking diachronic international and crossinstitutional understanding of the collecting of indigenous latin american material in europe in doing so the becaco team will reconstruct how through the formation of collections the indigenous latin american art world as it existed in europe between 18502000 constructed a discourse of art aesthetics and academic research that shaped how indigenous latin america is represented and understood in europe until today
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molecular materials for passivation in large area perovskite solar modules
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perovskite solar cells pscs have emerged as highly promising nextgeneration photovoltaic technologies distinguished by their exceptional combination of superior photovoltaic performance and costeffective manufacturing despite their remarkable potential the commercialization of largearea pscs remains a formidable challenge presenting a critical obstacle in the field of perovskite photovoltaics the core objective of this project is to spearhead the development of efficient and durable perovskite solar modules psms that are pertinent to industrially relevant scale we aim to demonstrate power conversion efficiencies of 23 and 20 on 100 cm2 and 800 cm2 modules respectively to achieve this ambitious goal we will adopt an interdisciplinary approach to devise a novel strategy for absorber and interface engineering on a large scale this breakthrough method will enable uniform crystal growth on a large scale resulting in perovskite films with high homogeneity and creating interfaces with nanoscale uniformity and robust interfacial adhesion in largescale modules the stability of these modules will undergo rigorous testing in accordance with iec and isos protocols simultaneously alongside the devicemodule fabrication and stability testing phases we will embark on fundamental investigations utilizing advanced techniques to gain a comprehensive understanding of the materials operational mechanisms within the modules this project capitalizes on the host labs extensive proficiency in perovskite module fabrication which is complemented by the applicants strong background in material design and synthesis this project will not only significantly enrich the fellows skill set but also instill invaluable leadership qualities and management skills poised to shape their future career
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ngi zero core
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we fund a large amount of third parties to review and upgrade the open internet architecture hardware software protocols to increase the performance of the network adapt it to new application requirements improve quality of service make it more resilient to security threats more energy efficient and respectful of the environment eg reparability recyclability and increasingly supportive of open and decentralised technologies and services with the size of the budget available and our methodology ngi0 core involves 150 000 to 300 000 person hours of directly funded human effort contributed to the public benefit and the good of the internet a multiple of that will be generated indirectly within the ecosystem around open source and standards ngi0 foundations is important to set the course of the evolution of technology and strengthening the role of europe within future developments in all this we benefit from decades of experience including significant experience gained within the various ngi efforts we have supported
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supporting local economic development with business transaction data
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this project aims to develop tools and solutions that turn valueadded tax vat records into an information system that can support evidencebased policy making and the development of regions industries and firms in general
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automatic personalised makeup application
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to meet societal expectations the average woman finds herself having to spend two years of her life sitting in front of a mirror applying makeup several wellknown issues make the selfapplication of makeup a challenging and inconvenient task that negatively impacts womens quality of life the majority of women report a lack of confidence in their ability to apply their makeup well the situation is even worse for women of color who are not offered enough variety of shades and for one in four women in the us with a physical disability impacting their ability to apply makeup yet the 511 billion dollar beauty industry continues to offer women no better alternative than the traditional makeup tools that have existed for decadesmodern women need access to a more convenient makeup experience and we believe that automation is the key that is why beautai is developing the worlds first automatic makeup application machine to help busy women achieve any makeup look in under four minutes by automated airbrush mechanics and proprietary realtime color mixing
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regions4climate
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increasingly frequent extreme weather conditions due to climate change concomitant with unsustainable historical resource use and management practices create the perfect storm threatening our livelihoods wellbeing and environment a transition towards resilience requires that we simultaneously address social inequalities and implement crosssectoral innovations to build social economic and environmental resilience to extreme events together regions4climate partners commit to addressing current and forecasted climate changerelated challenges and building more resilient european communities within an innovative socially engaged citizendriven paradigm we aim to develop smarter more inclusive more resilient regional ecosystems through crosssectoral innovation jointly created with stakeholders by and for people the development and implementation of crosssectoral strategies that incorporate combinations of social technological digital business governance and environmental solutions to common climate resilience challenges is at present constrained by knowledge deficits and uncertainties as well as sciencepolicystakeholder gaps regions4climate will bridge these gaps and address existing uncertainties by further developing adapting and integrating stateoftheart technical knowhow innovative tools and collaborative practices to support transparent evidencebased risk and vulnerability analyses and robust decisionmaking processes we will utilise system dynamic modelling to understand relationships among and tradeoffs between different resilience innovations providing tools for informed decisionmaking tailored to engage stakeholders and support european regions and communities exposed to significant climate change impacts new scientific insights along with a framework of interoperable tools methodologies and demonstrated solutions will enable european regions to develop their own resilience plans and transformative adaptation pathways
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disrupting the cooling and heating industry a revolutionary green energy efficient and cost competitive magnetocaloric technology platform
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magnetocaloric mc heat pumps can unlock sustainable heating and cooling by limiting ghg exhaust so far nobody has been able to create a commercially sustainable product due to high costs of rareearth materials needed magnetos technology has based on our patented composition of mc material for the first time ever developed a heat pump using affordable and available non rare earth materials our heat pump will enable scalability to the most price sensitive markets northern european countries with high energy costs incoming regulation on ghg emissions and an increased need of commercial cooling equipment due to urbanisation with eic support we will expand our current temperature span and run first pilots in commercial cooling sector by 2025 it will prove our product and business model increase market attraction and improve our further fundraising position we plan to reach breakeven by 2027 and a revenue of 85 million with a gross margin of 78 by 2029
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clean and efficient cooling in vaccine transportation using rotating magnetocaloric effect
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every year 15 million lives are lost worldwide due to insufficient access to vaccination while paradoxically over 50 of all produced vaccines are wasted mostly due to ineffective temperature control during storagetransportation the major challenges of the vaccine cold chain are the evermore strict limitations imposed on their aerial transport due to the safety hazards of refrigerant gases the highpower demand of active refrigeration devices in lastmile deliveries where the electricity supply is unreliable and the significant carbon footprint of high global warming potential refrigerantsthe magccine project aims to revolutionize the vaccine cold chain by developing a clean and efficient solid state magnetic refrigerator based on a novel approach the rotating magnetocaloric effect rmce a recently 2023 patent pending technology by project partners by reducing the amount of permanent magnets required the rmce is expected to enable drastic cuts in the devices production cost volume and weight while enhancing efficiency without the use of any high gwp or hazardous refrigerant gases highlighting its role as a key enabling technology for tackling vaccine cold chain challenges magccines goal is to develop and optimize a fully operational prototype for vaccine refrigeration in the 28 c temperature range which is required by most vaccines addressing the generation of clean cooling and clean cold chain transportation categories of this challengeto this end this project requires toplevel expertise on magnetocaloric materials magnetic field design thermodynamic simulations and heat pumps which are perfectly matched by the complementary expertise of the five academic institutions uporto cnrs u seville uaveiro uljubljana and the two industrial partners magreesource helium 3 our endeavors will be guided by an experienced advisory board including global key leaders such as who unicef cemafroid apirac iir medgree and addvolt
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single pilot line operations
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solo intends to pave the way for the commercial operations of next generation airliners proposing single pilot operations which are anticipated within the next decadeto this aim solo encompasses one single operational solution that will produce a trl 4 atm concept of single pilot operations this will initiated based on previous works initiated by airbus and atr with the support of french partners dsna eurocontrol enac and as well be based on the technological bricks developed during those previous rt activities in support to airbus and atr the maturation and validation of this concept will be done with the formal cooperation of dfs enairecrida eurocontrol dsna nats and indra indeed one major constraint for the trl 4 concept will be to reduce to the minimum necessary the impacts on atc tools and proceduresairline functions and tools will need to be enhanced to prepare and execute single pilot operations in addition to the major evolutions needed at the cockpit side not the purpose of solo several airlines had on an anonymous way supported airbus and atr for several years it is planned that a similar way of working will be done during the execution of the projectin the end the trl 4 concept of operations instantiated by a comprehensive sprinteroposed will feed further more specific rt activities and as well provide solid basis to various standardization and regulatory bodies such as icao easa faa caac
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moving russians intergenerational transmission of memories abroad and at home
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children of migrants are exposed to two national histories those told in their country of residence and those relating to their familys homeland however it remains unclear how the intergenerational transmission of historical views shapes the relationship migrants cultivate with here and there applying theories of intergenerational transmission and secondgeneration transnationalism movemeru addresses this urgent gap and compares the historical memories of migrants and nonmigrants across two generations it studies the russian migrant population in a favourable hostile and neutral reception context looking at germany estonia and canada like many other autocracies russia uses historical memories to appeal to the emotions of citizens at home and abroad and strengthen their sense of belonging to russiathe project will make major academic contributions in three areas 1 understanding the historical identification of young adults in migrant and nonmigrant families with their parents country of origin 2 identifying when the memories of migrant and nonmigrant families converge or diverge across generations 3 determining what historical memories contribute to solidarity and pluralistic political attitudesmovemeru entails a groundbreaking triangulation of methods 1 parentchild opinion surveys on views on history among migrant communities and nationals in the three countries of destination and russia 2 crossgenerational focus groups in the same countries 3 analysis of historical narratives in media targeting russian speakers abroadthe project will refine our understanding of differences and similarities in the intergenerational transmission of memories in migrant and nonmigrant families offering important insights into the drivers of and obstacles to integration the results have major implications for political decisionmaking in countries of destination and for public awareness about intergenerational shifts within migrant communities
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care circular consumption activities to transform households toward material efficiency
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care aims to empower consumercitizens in european households in the transition to a circular economy ce the objective of care is to transform a total of 100 households in five european countries finland norway sweden germany and estonia to circular model households to achieve its aim care will further develop test and validate two pilots related to two critical material flows food and clothing they both have high potential for circularity at the household level the care pilots will be implemented in five regions both urban and rural that are part of the circular cities and regions initiative ccri tampere asker gothenburg berlin and lneharju the pilots are based on the practicetheoretical approach which goes beyond stateoftheart by focusing on holistic social and material aspects of everyday life instead of individualistic and awarenessraising interventions the pilots will contain both customized inclusive and costfree circular advisory services as well as food and clothing related interventions that target changes in consumption practices impact assessment is a key part of the project that includes improvement in material efficiency living conditions and sustainable wellbeing the effectiveness of the pilots for reducing environmental impacts will be calculated using life cycle assessment especially the product environmental footprint method care will make a strong contribution towards accelerating fair inclusive and sustainable consumerbased transition to ce this is achieved by involving consumercitizens nongovernmental and civil society organizations municipalities researchers and ccri regions in a transdisciplinary approach based on codesign and colearning furthermore care will ensure the replicability and multiplication of its results through easytouse communication and dissemination tools in collaboration with ccri and other european circular economy initiatives
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phabased innovative agricultural solutions to deliver biobased fertilisers and plant protection products
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agrochemicals ie fertilizers and pesticides are responsible for doubling crop yields over the last century however they cause multiple negative impacts on environmental and human health to lessen their effects the eu aims at reducing by 50 fertilizer losses and use of chemical pesticides by 2030controlled polymerbased delivery systems preventing agrochemical losses eg lixiviation volatilization and resulting excessive inputs are available however they are based on nonbiodegradable polymers and generate plastic pollutionother agricultural plastics mulch films and growth foams are used to maintain a prosperous plant environment and prevent agrochemical washoff minimizing the quantities to be applied however they also result in significant amounts of nonbiodegradable plastics being released into environmentphantastic tackles the reduction of agrochemicals and plastics pollution using phas a family of biobased biodegradable polymers phantastic will develop two families of delivery systems mulch films and growth foams based on phas containing active bioproducts amino acids hydrolyzed proteins microelements elicitors and plant growth promoting rhizobacteria pgpr instead of synthetic agrochemicals products will be demonstrated with end users trl6 on horticultural crops and trees in northern and southern europe experts in the safe and sustainable by design framework will guarantee compliance market acceptance will be guaranteed through the development of business cases and exploitation strategiesphantastic will contribute to a significant reduction of agrochemicals minimum 25 in fertilizers 50 in pesticides resulting in 23 k tons less of agrochemicals by 2050 and plastic 680 t microplastics less by 2050 in our agricultural systems phantastic will thus contribute to a secure supply chain of food and a less impactful agriculture boosting the sustainability autonomy and competitiveness of vital eu value chains
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advancing cooperation on the foundations of law
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there are significant disparities between eu and noneu higher education institutions in terms of administrative and institutional capacity to successfully carry out the main task of legal education and research individual efforts and academic achievements of scholars from this part of europe are usually not accompanied by the appropriate administrative and institutional structures this situation makes it difficult for these institutions and their staff fully develop their capabilities in both academic research and legal education alf aims to help the faculty of law of the university of belgrade bgl a widening country institution to become a widely known and soughtafter topclass european research institution by raising its academic research profile and by strengthening its research management and administrative capabilities to this end alf will provide a thorough and comprehensive threeyear transfer of academic and administrative foundational knowledge from three leading institutions at eu level the university of genoa the university of surrey and the instituto de ciencias juridico politicas da faculdade de direito da universidade de lisbon alf fulfils five objectives of the horizon twinning action a it enhances the excellence capacities and resources of the bgl thus closing the still evident research and innovation gap within europe
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new latestage functionalization reagents for the construction of chiral centers to impact drug discoveryhis her
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latestage functionalization lsf is a rapidly expanding field in molecular synthesis with the major goal of quickly accessing to derivatives that would be too challenging or timeconsuming to prepare otherwise hence this strategy has a great potential to impact drug discovery processes by speeding up the hittolead optimization at present more than twothirds of prescription drugs contain at least one chiral center however the latestage introduction of this structural motif using aromatic ch bonds is an enduring challenge in synthesis the goal of the nakedc project is to develop a new methodology for the construction of chiral centers in drug molecules relying on the design and synthesis of a novel class of atomic carbon precursors that upon successive and appropriate activations would allow to build tailored asymmetric carbons to achieve this goal a new visiblelight photoredox catalytic diazomethylation of aromatic ch bonds will be developed the collaboration with an industrial partner secondment at aicuris will allow the application of this novel strategy to drug discovery in the search of effective antibiotics thus merging multidisciplinary aspects with intersectoral knowledge transfer the result will be a brandnew assembly point for the construction of chiral centers in bioactive compounds with the potential to become a latestage diversitygenerating synthetic platform for drug discovery programs the proposal merges the host expertise in novel ch functionalization strategies based on photocatalysis and the researchers background in classical radical chemistry metalmediated synthesis and pharmacology ensuring the twoway transfer of knowledge between the fellow and the host group successful development of nakedc will enhance the scientific and transferable skills of the researcher while forthcoming to the fellows professional goal of pursuing an independent research career in academia in synthetic organic chemistry
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unmannedpowertomethanolproduction
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it is a great challenge to upgrade decentralized co2 pointsources to production sites for renewable fuels these co2 sources can be related for example to production of biogas in anaerobic digestion plantsuptome targets a groundbreaking change in decentralized powertomethanol production for hard to electrify applications like marine vessels the potential of producing renewable methanol only by utilizing the co2 content of biogas in europe is 128 mta uptome concept is based on a hybrid process which combines the capture of co2 with the synthesis to methanol in a fully autonomous unmanned plant the process comprises 3dprinted reactors and column packings designed using highly advanced computational fluid dynamics the fully automated selflearning and selfoptimizing control system allows production at fluctuating conditions by combining dynamical plant models and artificial intelligence the aim of uptome to provide selfoptimizing control even for offgridoperation is very challenging and to our knowledge has not yet been achieved anywhere for comparable plants the ability of a remote plant to adapt itself to varying boundary conditions such as availability of renewable energies eg from weather forecasts or on the availability of co2 from a fluctuating source open unforeseen possibilities for distributed production currently socalled blue methanol originating from natural gas is used in limited cases as a marine fuel however the quality requirements of a renewable marine methanol fuel especially considering water content organic and sulfur impurities originating from p2x production are not known uptome will assess experimentally the suitability of the produced fuel on a marine type of engine and provide ranges for fuel specifications and max limits for impurities for this to become a sustainable marine fuel
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strategies for achieving equity and inclusion in education training and learning in democratic europe
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stride will provide a new comprehensive and comparative knowledgebase on effective education reforms policy initiatives and interventions aimed at reducing inequalities in education training and learning outcomes in europe stride will do this through analyses of education reforms in national and regional systems existing largescale educational assessment data and existing longitudinal data on the causal link between educational and other social policies and inequalities in educational achievements in examining the learning progress of students over time stride will closely examine to the range of intersectional variables such as socioeconomic background gender disabilities migration status home language early childhood education and care ecec attendance which may affect learning outcomes in different ways in different contexts the project will combine diverse methods data and disciplines comparative education political science education science sociology in innovative ways mapping at national and regional levels on 1 education reforms in the past 25 years by policy analysis 2 longitudinal trends of inequalities in educational achievement by quasiexperiment analysis of existing largescale educational assessment data and 3 effect of education reforms and interventions by analysis existing longitudinal data and registry data following student cohorts over time combined with a qualitative inquiry into policymakers perspective through the involvement of national and european stakeholders stride will develop methodology and assessment tools for policy learning offering policymakers a toolbox of enhanced knowledge of what shapes educational outcomes over time and demonstrating the usefulness of longitudinal data in policymaking to reduce educational inequalities in the short medium and long term
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sustainability transition assessment rules for biobased systems
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star4bbs is a threeyear multidisciplinary and multiactor collaborative project involving seven partners three associated partners and one linked third party the overall aim of star4bbs is to maximize the potential of sustainability certification schemes scs and labels to support a successful transition to sustainable biobased economy at the core of the star4bbs project is the development of indicators and a new monitoring system for assessing the effectiveness and robustness of existing international and eu scs b2b labels and related traceability systems applicable to biological feedstock and biobased materials and products this information will create the foundations to support achieving the much needed harmonization between schemes and transparency in global and eu trade flows through the developed new monitoring system existing scs and labels will be analyzed and the results as well as additional research on certified and uncertified trade flows and on the impacts and costs and benefits of certification and labels will substantially increase understanding of the potential of these schemes to contribute to policy and industry sustainability goals and will build awareness of the differences between the schemes the project will involve important stakeholders including scheme owners policy makers and industry in the design of research and the monitoring system and in the development of practical recommendations emerging from the research and analysis in order to ensure that the project achieves its ultimate goal in particular an increased uptake of the most effective scs and labels by the biobased industry will support the development of circular climateneutral sustainable biobased systems that will mitigate climate change increase resource efficiency preserve and restore ecosystems biodiversity natural resources and the quality of air water and soil
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linking ukraine to the european research area joint funding and capacity building platform for enhanced research and innovation cooperation
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luke is an initiative of several eu member states and countries associated to horizon europe aiming to establish a multilateral funding and capacity building platform focusing on ukraine its key objectives are to implement a joint call and fund transnational research and innovation ri projects with ukrainian participation as well as to enhance ukraines ri capacities a modern efficient and transparent science and innovation system is crucial for ukraines postwar recovery and economic prosperity sharing best practices pooling resources and transferring knowledge can significantly contribute to unlocking ukraines scientific potential improving the framework conditions for research and innovation and integrating the country more closely into the european research area erathe luke network comprises a group of funding parties and the project consortium responsible for accompanying activities the overall coordination and management are conducted by a call secretariat altogether 19 organisations from 13 countries have already confirmed their willingness to participate as funders within the network austria the czech republic estonia finland germany latvia poland romania switzerland ukraine itself as well as the eu accession candidates georgia republic of moldova and türkiye additional funding agencies have expressed interest in joining and may be included in the group of funding parties once the joint call has been finalized the project consortium includes nine organisations amongst them the german aerospace center dlr as coordinator the national research foundation of ukraine including the horizon office and science council centre for social innovation austria danish board of technology dbt and university of daugavpils latvia
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humancompatible artificial intelligence with guarantees
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in this proposal we address the matter of transparency and explainability of ai using approaches inspired by control theory notably we consider a comprehensive and flexible certification of properties of ai pipelines certain closedloops and more complicated interconnections at one extreme one could consider risk averse a priori guarantees via hard constraints on certain bias measures in the training process at the other extreme one could consider nuanced communication of the exact tradeoffs involved in ai pipeline choices and their effect on industrial and bias outcomes post hoc both extremes offer little in terms of optimizing the pipeline and inflexibility in explaining the pipelines fairnessrelated qualities seeking the middleground we suggest a priori certification of fairnessrelated qualities in ai pipelines via modular compositions of preprocessing training inference and postprocessing steps with certain properties furthermore we present an extensive programme in explainability of fairnessrelated qualities we seek to inform both the developer and the user thoroughly in regards to the possible algorithmic choices and their expected effects overall this will effectively support the development of ai pipelines with guaranteed levels of performance explained clearly three use cases in human resources automation financial technology and advertising will be used to assess the effectiveness of our approaches
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trusted lifetime in operation for a circular economy
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climate change co2 footprint energy transition safety security as well as sovereignty are key issues that the common population can very well relate to today as we face critical challenges research and development in our ecs domain needs to address them more than ever in particular the energy transition needs to be accelerated in order to become more independent from gas and oil energy which was considered being available at low costs and without limits until recently this assumption has been proven to be based on very fragile grounds and it has come to an end one solution to accelerate the energy transition is to use all generated energy this means that overflow energy produced in wind or solar parks needs to be available in periods when common energy generation is lacking this requires important investments into infrastructure which will only flow if investors trust into the technologies enabling solutions the faster the trust is built the faster the transition can be realizedon the other hand technologies and products that will ensure an economic use of resources and enable long and trusted lifetime of systems and components in the ecs domain have to be developed archimedes contributes to this in the domains of automotive aviation and industry in archimedes components models and methodologies to increase the efficiency and lifetime of the propulsion components power components and energy storage devices in automotive aviation and industry will be developed this will support the energy transition on the consumers side in order to support this mission archimedes aims to change technologies and products in the automotive aviation infrastructure domains and the related ecosystem towards a resilient decarbonized digitalized and green eu it will help building trust in the new technologies and thus contribute to accelerating the energy transition safety and security
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timevarying nonhermitian metamaterials for microvibration isolation
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precision instruments with high performances are highly demanded by both fundamental science and wide applications at different scales microvibration isolation technology is widely required in order to avoid potential damage of functions the current vibration control technology mainly includes passive and active control however it remains limits in control accuracy and bulk size which requires to explore new physical mechanisms recently nonhermitian system and spatiotemporal modulation show great potential in wave control for anomalous properties and provide a promising avenue to address the microvibration isolation challenges non hermitian parameters and timevarying modulation can play additional degrees of freedom to enrich elastic wavestructure interactions this project focuses on elastic wave propagation in nonhermitian elastic beamsplates with timevarying modulation for microvibration isolation the project will first conduct an indepth study on the modeling of timevarying nonhermitian unit and explore the mechanism of wave isolation with single unit then study the wave isolation mechanisms from exceptional point with double units and broaden the wave isolation band with multiple units finally ondemand inverse design will be developed and experimental validation will be implemented the proposed timevarying nonhermitian elastic systems will guide a new direction for the next generation microvibration isolation technology
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a new bayesian foundation for psychometric network modelling
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network modelling is quickly gaining ground as a promising way to understand psychological phenomena the rise of network analysis can be observed throughout the psychological sciences but has been particularly influential in psychopathology while the network modelling literature has been rapidly expanding methodological innovations struggle to keep pace reviews taking stock of the field invariably zoom in on the methodological challenges that network research faces the absence of a confirmatory scheme the replicability of network results and the struggle with population heterogeneity rank firmly among the fields top priorities these methodological challenges critically impede our understanding of psychological phenomena and the design of effective interventions this proposal outlines a new research program for psychological network modelling that addresses current methodological challenges based on the basic principles of bayesian inference i develop a new confirmatory network methodology that uses modelaveraging to deliver robust replicable network results the new modelaveraging approach will be designed for an exhaustive collection of network models and for crosssectional and longitudinal applications i will develop new models that are urgently neededbut missing from the current set of networksand advance solutions for modelling heterogeneous psychological data to complete the new program the proposed work puts psychological network modelling on a firm methodological foundation to boost the projects impact the new methods and models are made available in jasp jaspstatsorg a userfriendly free statistical software package that i codeveloped armed with an exhaustive set of network models a confirmatory methodology that delivers replicable results and their implementation in opensource software applied researchers can leverage the full potential of psychological network modelling
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clinical validation of artificial intelligence for providing a personalized motor clinical profile assessment and rehabilitation of upper limb in children with unilateral cerebral palsy
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unilateral cerebral palsy ucp is the most common neurological chronic disease in childhood with a significant burden on children their families and health care system aincp aims to develop evidencebased clinical decision support tools dst for personalized functional diagnosis upper limb upl assessment and homebased intervention for children with ucp by developing testing and validating trustworthy artificial intelligence ai and costeffective strategies the aincp approach will i establish a clinical diagnosis and accurate prognosis for treatment response of individual ucp profiles by employing a multimodal approach including clinical phenotyping advanced brain imaging and reallife monitoring of upl function and ii provide personalized homebased treatment from advanced ict and ai technologies the aincp will build upon personalized diagnostic and rehabilitative dst ddst and rdst to be developed and validated through large observational and rehabilitation studies including at least 200 and 150 children with ucp respectively using data driven and ai approach ddst and rdst will be combined for developing a theranostic dst tdst that will allow the redesigning of an economical ethical sustainable decisionmaking process for delivering a personalized and validated approach focused on the care monitoring and rehabilitation of upl in children with ucp aincp is a significant example of a transdisciplinary approach where all project collaborators clinicians data scientists physicists engineers economists ethicists smes children and parent associations will work closely together in building the aincp approach this approach will therefore hinge on transdisciplinary contributions multidimensional data sets of innovative devices and fair aibased algorithms clinically effective and able to reduce users and market barriers of acceptability reimbursability and adoption of the proposed solution
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building a european community of practice of hubs for circularity
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h4c europe project will create a european community of practice ecop it will provide a community knowledge platform and exchange structures that will help the existing and future hubs in creation management and growth by overcoming barriers to isiusc the ecop is set up to be selfsustaining 10 existing hubs have committed to join as ecop founding members the ecop will preserve the findings of isiusc research and innovation projects especially those funded by the ec and member states it will organize a continuous exchange of ideas and best practices and facilitate indepth exchanges between experts to identify bottlenecks evaluate the outcomes of related projects and propose innovative approaches to overcome bottlenecks possible topics include the financing and operation of is infrastructures matching demand and supply in is and ius sharing benefits crossborder exchange of materials water and wastewater systems regulatory issues in the use of secondary raw materials the tension between reuse and use of waste as feedstock to name a few digitalization is a transversal enabling aspect of isiusc and the usage of digital tools will be an important aspect of each expert group in line with the call and to achieve its vision the csa will work along four axes 1 sustainable community building and establishment of an it knowledge platform as a tool 2 consolidation and creation of available knowledge by analysis of the state of the art indepth discussions of leading experts and field trials of business models and financial strategies ao for largescale demonstrators 3 development of a kpi toolkit for the assessment of the maturity of isiusc regional initiatives towards h4c and independent evaluation of h4cs as candidates for lighthouse projects as well as the elaboration of policy recommendations 4 promotion of the h4c concept societal engagement and policy recommendations
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novel design of offshore wind farms by employing highfidelity computations to mitigate their acoustic impact on marine life
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whalenoise emerges as a timely and essential initiative born from a dual sense of purpose driven by two pressing concerns firstly with the urgent need to achieve ambitious targets in clean energy generation the european union set forth its 2020 strategy on offshore renewable energy aiming for a remarkable 300 gw of offshore wind capacity in response to this accelerated timeline the development of offshore wind technology has seen rapid advancements to meet the escalating demand for clean energy secondly over the past 20 years the world has witnessed a remarkable surge in awareness regarding acoustic pollution in the oceans this awareness is evident through the increasing number of scientific publications on the subject and the implementation of new regulations aimed at protecting the hearing thresholds of marine animals two commonly cited problems with respect to marine renewable devices are collision risk and noise impact the former is concerned with marine life being unable to determine the locations of devices also known as the masking problem and may be alleviated by introducing specially designed warning devices the latter regards the damaging effect of acoustics generated by the turbine on marine animals eg noise masking communication between individuals and can be reduced only via a redesign of energy farms whalenoise aligns with these environmental imperatives as it addresses both challenges in a synergistic manner its core mission is to understand and predict the acoustic emissions from offshore wind farms fixed and floating seeking to evaluate their detrimental impact on marine life by striking this delicate balance between clean energy generation and ecological conservation whalenoise promises to contribute significantly to a sustainable and harmonious future for our oceans and the life they nurture
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holographic assembler for 3d cell cultures
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cell cultures are essential for biomedical research and drug screening the environment and the arrangement directly affect cell function it has become clear that biological cells behave differently when cultured on a surface as opposed to a 3d environment this discrepancy between 2d in vitro studies and the 3d environment found in vivo is critical for cancer research most notably patientspecific therapy and highthroughput drug screening and discovery almost 90 of all drug candidates fail during the trial phases and one of the main reasons identified is the low physiological relevance of 2d cell cultures technologies are needed that enable the fast and efficient culturing of 3d cell assemblies with high repeatability and control over size and morphology here we use our recently developed technology and fabrication knowhow together with the expertise from our ercfunded research to realize the first 3d bioassembler where the shape of the cell aggregates can be precisely defined by the user within this ercpoc grant we plan to develop a fully operational standalone benchtop bioassembler that instantly aggregates biological cells spheroids particles or hydrogel capsules into fully defined 3d structures using acoustic holography our device will be an easytouse and affordable instrument that is fully compatible with established biological procedures and laboratory equipment and which allows scientists to culture the specific cell structures they need the grant will allow us to protect our knowhow identify further markets and develop a commercialization strategy for our technology overall this project will generate the first 3d cell assembler that permits the generation of userdefined cell spheroids and custom shapes at a press of button and thus presents an innovation with a sizeable market potential
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fast electrooptic fluorescence lifetime microscopy eoflim for superresolution microscopy and brain surgery
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fluorescence lifetime imaging microscopy flim is a powerful method for monitoring physicochemical parameters of cells and tissues as well as biomolecular interactions with applications in science medicine and industry however its use is currently limited due to technological constraints regarding frame rate and sensitivitywe have developed a flim detector that enables highly sensitive highspeed flim it is based on the use of electrooptical elements as temporal gating units electrooptical flim eoflim enables frame rates beyond 100 hz for megapixel images singlemolecule sensitivity and highresolution imaging numerical aperture 13we will demonstrate the innovation potential of our detector in two key applications superresolution flim and surgical flim superresolution flim will be done in collaboration with prof huser univ of bielefeld we will apply our eoflim detector to superresolution microscopy at high frame rates in live cells and tissues surgical flim will be done in collaboration with prof unterhuber medical univ of vienna and will aim at diagnosing cancerous tissue in brain biopsies superresolution flim and surgical flim will demonstrate the wide applicability of eoflim in research and medicine
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rebuilding the foundations of planet formation protoplanetary disc evolution
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with thousands of exoplanets known we have truly entered the exoplanet era explaining the huge diversity of observed exoplanetary systems remains however a big challenge the only way we have to study planet formation is to study the environments in which they form protoplanetary discs to understand planets we have to understand discs and the physical processes happening in themthe field of protoplanetary discs is currently being shaken by the crumbling of viscous theory the traditional paradigm used to describe how discs evolve in time the paradigm relied on the presence of turbulence which affects a myriad of processes of planet formation the crumbling of viscous theory thus has ramifications across our entire understanding of planet formationhow can we rebuild the foundations of planet formation thanks to advances in observational capabilities we can now perform large surveys of protoplanetary discs and study the evolution of their properties mass radius mass accretion rate over the last few years i played a leading role in showing how to use this information to guide and constrain models of disc evolution computing quantities from the models that can be directly compared to observationsbuilding on my expertise at the convergence of theory and observations i propose a to develop quantitative models of an alternative paradigm of disc evolution in which discs evolve under the influence of disc winds rather than viscously the longlasting impact of discevol will be to deliver a new standard model of disc evolution tested against the existing data from observational surveys discevol will also b reassess how crucial steps of the planet formation process such as the accretion of solids onto growing planetary cores and planetary migration differ in a disc evolving under the influence of winds altogether this program will bring the link between models and observations of planet formation in discs to a new level
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multiscale modelling of aberrant phase transitions in biocondensates
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the spatiotemporal organization of the cell material represents one of the great wonders in physics chemistry and biology compartmentalization plays a key role in such precise molecular coordination and enables cellular function over the past decade transformative experiments have revealed that most intracellular compartments are not enclosed by membranes but instead they are dynamical assemblies termed condensates and thought to occur via liquidliquid phase separation of biomolecules nevertheless the misregulation of these condensatesmostly formed by proteins and nucleic acidscan give rise to deleterious solidlike aggregates which are associated with the proliferation of agerelated and neurodegenerative disordersinphase aims to develop an innovative computational approach to resolve the dynamical behaviour of molecules inside functional condensates that drift their complex physicochemical behaviour into pathological solid aggregates to this end we plan to develop a multiscale modelling platformcombining coarsegrained force fields and atomistic simulationswhich will address the following critical questions what are the encoded molecular features in rna and protein sequences regulating phase behaviour what pushes biomolecular condensates to shift their material properties over time can we prevent the proliferation of pathological aggregates induced by condensate misregulation the overarching goals of this project are 1 to understand the thermodynamic and intermolecular forces driving condensates outoffunction and 2 devise potential strategies for preventing rnaprotein aberrant phase transitions in biomolecular condensates this alone is groundbreaking because it will reveal the underlying mechanisms and interactions by which the structure and sequence of rna and proteins dictate the material properties of intracellular condensates and their implication in cellular dysfunction
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magnetic energy conversion for waste heat
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the production and use of energy account for more than 75 of the eus greenhouse gas emissions decarbonising the eus energy system is therefore critical to reach our 2030 climate objectives and the eus longterm strategy of achieving carbon neutrality by 2050 obviously solar and wind power will play an important role in any future energy scenario but such intermittent sources present significant challenges in energy transport and storage at the same time a vast amount of lowgrade heat is generated eg in datacentres food pulp and paper industries and is available 247 even converting only a small percentage of this heat into electricity is significant due to the sheer amount of heat wasted just above ambient temperature however efficient technologies to convert this lowgrade heat in an economically sound way are lacking within this project we will develop thermomagnetic harvesting from current trl 34 proofs of principle to an efficient and cost competitive trl 67 technology our interdisciplinary consortium of 9 academic institutes and 4 industrial partners address all major challenges for this emerging technology which requires innovative designs of more efficient thermomagnetic generators that are intimately connected with tailored thermomagnetic materials our team consists of engineers who invented thermomagnetic systems at various sizes and power ranges materials scientists with ample experience in advanced magnetic materials bulk or film preparation and characterization and physicists who cover modelling from the ab initio scale via micromagnetism at the mesoscale up to the macroscopic device scale this rich multidisciplinary environment will allow training of 10 young professionals by crossfertilization with fresh ideas they will obtain the interdisciplinary competence required to bring this green technology to a mature level and career perspectives in both the academic and nonacademic sectors delivering the green deal
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cryptogam biodiversity dynamics under climate change in the arctic and antarctic poles
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earths polar regions are warming at unprecedented rates antarctica is experiencing rapid regional warming and the arctic has warmed up to four times the global average in response vascular plants have experienced shifts in species abundance and distribution polar regions host large richness of cryptogam species bryophytes and lichens which are essential ecosystem regulators that contribute to nutrient cycling soil moisture and energy balance despite these crucial roles and expectations that cryptogams can be seriously affected by climate change taxonomical challenges hinder our understanding of their current trends bipolar will tackle this knowledge gap by quantifying polar cryptogams climatic niches to understand their potential for climate change adaptation both poles contain similar habitats shaped by extreme conditions but the arctic is warming more rapidly than antarctica and ecological processes have been more extensively documented there bipolar is an interdisciplinary project that will provide a window into the future of antarctic cryptogams by using the arctic as a sentinel region via bipolar cryptogam species ie present at the two poles bipolar will combine a variety of methods and data ie palaeoecology openaccess datasets fieldwork and bayesian statistics and employ historical and current data to inform future projections the three objectives of bipolar are 1 compiling and standardising bipolar cryptogam data from multiple sources 2 quantifying past present and future macro and microclimatic niches and identifying winner and loser cryptogam species and 3 validating species occurrence and climate data through fieldwork this research will provide a foundation for conservation as these regions become progressively more ice and snowfree while strengthening currently fragmented arctic and antarctic research links and bringing together the polar research community
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minimum environmental impact ultraefficient cores for aircraft propulsion
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building a sustainable and climate neutral future for aviation is an inevitable requirement for a society with increasing mobility needs if we are to stabilise the global temperature below the 15c threshold set by the paris agreement rapid action is to be taken minimal will contribute to a radical transformation in air transport by providing disruptive ultraefficient and lowemission technologies that will in combination with the aviation ecosystem sustainably reduce the climate impact of aviation the minimal project will through an unprecedented effort between european engine oems world leading atmospheric physics scientists and lead researchers in combustion and propulsion attack the major sources of nonco2 and co2 emissions in aeroengines this will be accomplished with the introduction of climate optimised new propulsion systems based on composite cycle engine technology that provides unparalleled flexibility with respect to operations and that has the potential to eliminate the large sources of effective radiative forcing by 2035 80 reduction from contrails 52 reduction from netnox and 36 fuel burn reduction resulting in 36 to 100 co2 reduction depending on the fuel usedresults will allow assessing the interdependencies between nonco2 and co2 effects already during the early stages of aerothermalmechanical design and converge into engine options that have minimum climate impact the findings are supported by numerical trl 2 and experimental trl 3 proof of concept of lownox opposedpiston constant volume combustion technology with premicromixing of hydrogen in minimal we understand the urgency and aim for maximum impact aggressive but realistic roadmaps will be outlined together with regular exchanges in major industry research centres to develop these technologies into products and bring them to in 20352040
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noninvasive conduction velocity mapping in brain networks a novel imaging framework for axonal fingerprinting of brain connections in health and disease
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axonal bundles in cerebral white matter form the structural basis of functional brain networks enabling effective integration of neural activity the axonal connections are not homogenous structures axons differ in diameter and myelination enabling signal conduction at different velocities this axonal diversity is a clinically relevant microstructural feature as neurodegenerative or neuroinflammatory processes can affect axon diameters differently recent advances in magnetic resonance imaging mri have enabled the noninvasive mapping of the microstructural properties of brain network connections in live brains but attempts to correlate these structural features with brain function have not yet been successful i have pioneered the mapping of axon diameters that are directly linked to the conductive properties of axonal connections by using diffusion mri in living human brain also i have established an unique crossdisciplinary validation setup for such methods by combining nanoscopic 3d synchrotron radiation imaging and functional cellspecific targeting techniques by conduction velocity mapping in brain networks combrain i will be able to unravel the altered functional dynamics of the microstructural connections in the diseased brain methodologically i will push the frontiers of mri by creating a new translational combrain framework for noninvasive and invivo studies in animals and humans clinically combrain will provide a new window into the characterization of neuropathological changes in the diseased brain and contribute to the identification of structurefunction fingerprints of psychiatric and neurodegenerative disorders that are thought to be a major pathogenic factor in many brain diseases
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druggability of gquadruplexes promising modulators for antimicrobial resistance
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the antimicrobial resistance amr is an underrated problem promoted by widespread misuse and massive use of antibiotics thus the health systems are facing enormous costs to treat nosocomial infections due to amr bacteria in particular six highly virulent bacteria eskape are the main responsible for worldwide nosocomial infections in the last years our research strategies to discover and develop new clinically relevant antibiotics lacked effectiveness as a result we are unable to efficiently treat amr infections and are unprepared to face an amr bacteria outbreak one possible strategy is to target bacteria gquadruplexes bgqs which are highly conserved dnarna secondary structures pivotal for bacteria duplication transcription and translation this strategy is particular effective because when a new pathogen emerges its dnarna genome is first disclosed through sequencing hence the ability of quickly designing new drug candidates based only on this information will be a powerful tool to face a new epidemicpandemic furthermore the human gqs hgqs were largely investigated as possible target for anticancer treatment thus the interest in bgqs raised later and with less intensity than hgqs in addition most gqs modulators bind gquartets top by stacking interactions and the druggability of gqs loopsgrooves was still not addressed in this context the multidisciplinary of gqreat eskape project aims to provide a novel and effective strategy to contrast amr by targeting bgqs and to expand the knowledge on bgqs
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environmental control of physiology through the braingut axis
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a series of tightly controlled processes ensure that energy is either stored or consumed within an organism this control is central to survival and prosperity of the animal yet we only partly understand it communication between the brain and the gut the so called braingut axis has emerged as a key player in regulating aspects of animal physiology by directly affecting energy stores nevertheless due to the astonishing anatomical complexity of the underlying neural circuits in mammals an in depth understanding of the cellular and molecular mechanisms controlling this axis is still lacking using the simpler yet functionally comparable drosophila braingut axis as a model system i have recently shown that adult enteric neurons are functionally plastic this constitutes a physiological feature highly relevant for the adjustment of food intake by the animal to meet energy demands i explored this in females in the context reproduction where mechanisms underlying appetite regulation are evolutionary conserved across multiple species building on my expertise i will now investigate the longstanding question on how environmental factors such as dietary habits or levels of physical activity impact the function of the braingut axis for gutsense i will leverage the unique experimental opportunities available in drosophila to address the role of gutneurons in metabolic adaptation a characterize neurons which respond to these environmental cues and the relevant neural circuits and mediators b identify the target tissues and the nature of interorgan signals involved c investigate the impact of timing and duration of exposure to these factors on metabolic adaptation through these i will uncover basic and likely evolutionary conserved mechanisms and better understand the contextdependent tolerance of metabolic challenges such insight can lead the way in elucidating the contribution of braingut networks to the development of pathophysiology
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novel approaches to the quantum bounds to chaos
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the recent technological and experimental advances in the field of quantum simulation and computation have led to the renaissance of the study of the dynamics of complex quantum systems different interdisciplinary approaches merging concepts from condensed matter high energy physics and quantum information have emphasised the existence of constraints given by quantum mechanics on the time evolution of correlations and the transport properties the purpose of this proposal is to tackle several outstanding issues at the intersection of these fields from the perspective of standard quantum statistical mechanics the project integrates the applicants expertise in quantum manybody dynamics with the host broad experience in statistical mechanics taking full advantage of the unique multidisciplinary environment provided by the hosting institution the research will be carried out in the perfectly suited environment of the statistical physics group at the laboratoire de physique de lecole normale superieure with prof j kurchan
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memory reimagined gender and intersectionality in participatory memory configuration
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in the context of the colombian peace process this project undertakes an ethnographic exploration of a communitarian museum developed in cooperation between the colombian national museum and an organization of transgender activists in a marginalized neighbourhood of bogot drawing lessons from this innovative collaboration memoryreimagined investigates the inclusion of gender and intersectionality in participatory initiatives of memory configuration in the outgoing phase of this fellowship the ethnographic examination of this process of configuring participatory memory will explore the intersection of different forms of violence armed structural gendered and postcolonial violence and will delve into the practices of resistance developed by this project in the return phase to the host institution the applicability of the methodology examined in this project in an armed conflictaffected context will be explored in contexts of urban social conflict where intersectional violence and social stigmatization affect the everyday of marginalized populations through the coproduction of knowledge with participants in the project and the development of knowledge exchange with relevant stakeholders memoryreimagined is a form of applied ethnography that foregrounds marginalized memories and contributes to policy and practitioner knowledge of social engagement in memory institutions it further highlights the potential of memory initiatives to transform social inequality and reduce the continuation of entangled forms of violence this project advances the fields of feminist anthropology peace and conflict studies and museum studies nurturing the interdisciplinary field of memory studies the outcomes of this threeyear project will serve as both precedent and toolkit for participatory approaches to memory configuration bringing to european institutions and civil society innovative mechanisms for social inclusion and for the promotion of a culture of peace
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off the road the environmental aesthetics of early automobility
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in times of climate crisis there is wide agreement that we need a more environmental approach to automobility off the road addresses this challenge by highlighting a largely forgotten fact that automobility was a thoroughly environmental experience before the current system of closed cars on concrete roads emerged this environmental automobility was particularly widespread in the united states where much driving occurred in offroad conditions well into the 1920s motorists navigated through mud sand and water constantly exposed to the elements and acutely aware of their surroundings early automobility thus engendered unprecedented modes of relating to the environmentmodes that have never been systematically researched off the road recovers this environmental automobility by conceiving it as an aesthetic experience one that created new sensual perceptions new strategies of representation and new formations of environmental knowledge these aesthetic patterns found their most complex manifestation in road literature the project assembles researchers from literary studies environmental history and the history of knowledge to recover the aesthetics of environmental automobility in three steps 1 it builds an interactive digital corpus of american road literature from 1890 to 1929 to identify the full range of aesthetic strategies employed to render the experience of environmental automobility 2 it positions these strategies within the modernist aesthetic innovations of the period thus bringing into view a previously marginalized modernism inspired by slow driving in rural environments 3 it examines how the aesthetics of automobility generated a new kind of mobile environmental knowledge that shaped environmental activism and the emergent science of ecology in sum the project reveals how early automobility created distinct modes of environmental awareness that can help us reconceive mobility today
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