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safe tsunami early warning system using availableseafloor fiber cables
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according to the world health organization more than 700 million people live in lowlying coastal areas and small island developing states exposed to extreme sealevel events including tsunamis the cost of the most reliable currentlyavailable tsunami warning systems based on offshore sensors is extremely high and essentially only affordable to rich countries like the us or japan as such the vast majority of all this endangered population is not yet protected by this type of tsunami warning system luckily the vast majority of these coastal areas have alreadyavailable fibreoptic cables installed for communication purposes which could additionally serve as a key component for tsunami early warning at a marginal extra cost the objective of this project is to fulfill the need of protecting these communities which often have limited resources by providing a tsunami early warning solution based on the alreadyavailable fibre optic infrastructure the solution provided in this project will be simple to deploy and maintain just connecting an interrogator in the dry end of the fiberoptic cable low cost it will be several orders of magnitude cheaper than current systems reliable tsunami alerts will be confirmed by the same device using indirect measurements of sea level and timely the response time is expected to be faster than current systems the main market of this solution will be official meteorological and environmental institutions of different countries responsible for issuing early warnings
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understanding the role and biogenesis of transfer rnaderived small rnas in plants
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this proposal aims to explore the precise mechanism overall impact and complete population of the small rnas derived of transfer rnas tsrnas in plants the proposed research would be carried out in a laboratory that specializes in rna regulation and that made substantial contributions to the plant trnaderived srna field dr german martinez although it has been described that these molecules are highly expressed in stress conditions we still lack a clear understanding of the biogenesis pathways that lead to tsrna accumulation as well as of the array of biological processes they influence and their mechanism of action additionally because of the widespread presence of rna modifications in these molecules the unbiased genomewide quantification is not possible with the conventional sequencing technologies therefore these molecules represent a largely uncharacterized stressresponsive regulatory network in plants and thus an exciting source of potential applications for agriculture the experimental approach of this project will use a model plant arabidopsis thaliana in order to characterize the tsrna population and evaluate the importance of this regulatory layer under viral stress first a method to compare the accumulation profiles of tsrnas based on the enzymatic removal of rna modifications will be implemented second the biogenesis pathway of trnaderived srnas will be studied using mutant plants and how this affects viral infection will be evaluated with these mutant plants third the genes targeted by trnaderived srnas will be identified using a combined approach based on the immunoprecipitation of crosslinked ago proteins and ribosome profiling that determines the translation rate overall the data that this project would obtain has the potential to shift our understanding of tsrnas and provide cuttingedge applications for agriculture thus the completion of this project would provide me a considerable professional maturity
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bio2skin the first clinically skinpreserving biomaterial replacing siliconesacrylate as medical skin adhesives
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external medical devices such as ostomy pouches wound dressings or wearable electronic devices require the use of medical adhesives for their attachment to the skin however prolonged use of current medical adhesives is associated with serious adverse skin reactions marsi medical adhesivesrelated skin injuries this underreported issue is prevalent in 25 of wound care cases and is associated with enormous health care and economic burdens bh4u aims to address this challenge with bio2skin a patented revolutionary glueless medical adhesive that uses the natural features of the skin to establish a waterbased link and overcomes the disadvantages of acrylicsilicone adhesives bio2skin is a biobased costeffective recyclable solution offering gentle safe adhesion and kind removal the product with a potential of 250m eur by 2030 will be sold under license to medical adhesive manufacturers and external medical devices manufacturers
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optimised runway centreline interception
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orci will explore innovative aibased solutions to help increase runway throughput using advanced automation support tools in the tma domain specifically the objective is to provide key information to air traffic controllers in final approach sectors to support informed decisions on when to issue vectoring instructions to aircraft for optimal spacing between consecutive arrivals during medium high very highdensity and increasingly complex tma airspace operations to achieve this objective the project will develop an ai model that is trained using radar surveillance data and atc voice communications between pilots and controllersduring the project barcelona and lisbon approach operations will be assessed this will include interviews with atco experts from the respective ansp partners as well as indepth analysis of local arrival characteristics eg geometries procedures etc in addition high amounts of radar surveillance and voice communications data will be collected and processed to support and guide the training and testing of the ai modelsthe validation of the ai model will be supported by human in the loop and fast time simulation techniques using the rams plus tool to ensure that the performance of the ai model is evaluated in a realistic and controlled environment and to get some initial human performance and safety related feedbackthe successful implementation of the ai model is anticipated to optimize delivery of vectoring instructions leading to enhanced capacity efficiency environmental performance and overall improvements to arrival air traffic management that are consistent with sesar performance targets additional benefits also extend to optimization of the runway throughput by reducing both atc workload and the potential for human error the expected solution could also be extended to incorporate the use of timebased separation for arrivals and digitally shared trajectory information coming from the flightdeck
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degradation of micronanoplastics in water via fentonbased advanced oxidation processes under intensified conditions
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plastic debris including micro and nanosized particles is considered a top environmental problem that might affect human ability to preserve biodiversity and the availability of safe water supplies in the future hence there is a clear and urgent need for the development of targeted treatment processes for the effective removal of micronanoplastics mnps from water although advanced oxidation processes aops have been widely studied for the treatment of different emerging and recalcitrant water pollutants their application for mnps removal have been scarcely addressed among them fentonbased aops display significant implementation advantages which will be explored and optimized in the present project the main challenge consists in mineralizing pollutants that do not dissolve in water and were designed to be hardly degradable to face this problem plasticox pursues the development and intensification of advanced treatment strategies such as homogeneous fenton and photofenton processes to age and mineralize mnps in water this project seeks to tackle many of the knowledge gaps in the research field of this hot topic the mnps degradation will be assessed in terms of fragmentation polymer deterioration process efficiency intermediates identity and kinetic models based on particles with decreasing diameters moreover the effect of particle size shape and composition will be explored in depth my unique research background which includes material science catalysis reactor engineering and a preliminary training in polymer science will allow me to perform this ambitious project moreover i will collaborate and learn from my supervisors who have a vast experience in the field the marie curie fellowship will enhance the potential of my future career perspectives empowering me to take leading positions in the field of wastewater management worldwide moreover i expect to develop a lasting scientific cooperation with the european host group
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archaeological coastal heritage past present and future of a hidden prehistoric legacy
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dn arche trains 10 phd fellows for increasing the scientific and public value of europes archaeological coastal heritage focusing on the legacy of stone age hunterfishergatherers including some of the earliest remains of human activity this legacy is crucial for understanding human engagement with the coast yet it is fragile and highly heterogeneous with diverse material and cultural expressions it is embedded in a variety of geographic settings across europe differing in environmental development which face massive environmental and human threats it is also approached in various ways in cultural heritage management with little systematic integration of knowledge on the topic dn arche deals with the challenges of this fractured field with an innovative pastpresentfuture approach which focuses on connecting the legacy from the past its present status as archaeological heritage and prospects for its future protection and integration with six beneficiaries and nine associated partners arche unites academic research centres and nonacademic organizations cultural heritage sector specialist organisations museums media as a joint platform for research and training it leverages on customized phd projects crossfertilization of knowledge among researchers and partners scientific courses workshops conferences applied secondments and transferable skills training training in archaeology anthropology critical heritage studies heritage management bioarchaeology geology oceanography coastal engineeringpreservation and communication relevant to coastal heritage and environment equips arche phds with advanced interdisciplinary and crossregional knowledge and skills applicable to various academic and nonacademic fields across europe through best practices they will contribute to the visibility preservation and sustainable integration of the vulnerable cultural heritage in coastal areas facing global environmental and development challenges
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exploring the urbanism of roman mediterranean ports from iconographic data to 3d reconstruction
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under the roman imperial period mediterranean port cities were not only transit hubs where ships people and goods both departed and arrived but also places of urban and cultural life developing away from the seafront they formed a real urban landscape with enough characteristics of complete cities whose aesthetic and monumental features were widely emphasised in iconography although these highly codified images are not snapshots of reality previous doctoral research assessed the documentary value of iconographic evidence for understanding roman portscapes by inevitably confronting them with archaeological and textual data urbaport exploring the urbanism of roman mediterranean ports from iconographic data to 3d reconstruction is an interdisciplinary project that aims to understand the urban and architectural morphology of roman maritime port cities and to propose reliable virtual reconstructions of these environments to achieve this goal urbaport will propose an innovative reflection that will consider how iconographic evidence could be integrated to the digital tools for expanding the scientific value of historical restitutions in order to replace maritime activities in their architectural context urbaport will bring together an unprecedented combination of advanced computational methods 3d modelling and smart generative methods developed by the cnrsmc maparia laboratory ecole nationale suprieure darchitecture de lyon with the recent archaeological data conducted at portus the port of the imperial rome by the ecole française de rome in the perspective of a virtual exhibition at the archaeological park of ostia antica
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crete renewable energy valley
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crete valley aims to create a renewable energy valley living lab revlab in crete it is envisioned as a decentralised renewable energy system that combines leadingedge ict technologies interoperable and open digital solutions including data sovereignty social innovation processes and sound business models that are easy to adopt crete valley will demonstrate a digitalised distributed renewable low carbon landscape that is affordable for all and fully covers the local energy needs on an annual basis utilizing multiple renewable energy carriers and leveraging energy storage technologies the revlab will integrate four community energy labs cels located in distinct sites across crete valley conceived as innovation hubs an integrated social technological business approach will be deployed providing a social science framework for revlabs cels innovative multilevel governance models socialdriven mechanisms for involving citizens in the codesign implementation and exploitation of res aibased market segmentation algorithms mcda methods and consensus analysis for rev configuration interactive tools for rev planning rev readiness assessment computation augmented reality applications decision support tool energy data space compliant digital backbone for consumer and revlevel datadriven activation p2p dltblockchain digital marketplace for tokenised energy and nonenergy assets valuation and reciprocal compensation datadriven operational analysis advanced aiml tools and flexibility modelling services for optimal operation resilience of the local energy grid systemofsystem dig twin for multiple carrier grid management operation datadriven services and apps for energy efficiency and activation performance management towards energy autonomy enabling res technologies to increase the power production rev business sandbox and blueprints for revlab setup upscaling and replication including 4 follower communities
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origins and consequences of hematopoietic stem cell memories
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hematopoiesis has long been modeled as a stepwise hierarchical process where all blood cells arise from a single group of rare multipotent stem cells for decades various reports have contested this unifying paradigm indicating that hematopoietic stem cells are functionally heterogeneous and differ on the rates and types of blood cells that they produce however the origins of stem cell heterogeneity and importantly its physiological consequences have remained ambiguous my recent research suggests that individual stem cell behaviors are deterministic and programmed through longlasting epigenetic memories but how these different stem cell memories arise during development or injury is currently unknown intriguingly my preliminary results indicate that stem cell memories instruct not just their fate decisions but also the functional properties of their mature progeny thus raising the question of how stem cell memories create functional patterns that bias the cellular responses of their mature progeny thus the objectives of memoristem are 1 to uncover the mechanisms that establish the diversity of hsc memories during development 2 to identify the molecular determinants that maintain specific hsc properties and 3 to characterize how developmental and acquired hsc memories determine functional patterns in mature blood cell responses to overcome various challenging aspects of studying cell memories in vivo i have designed a groundbreaking approach that combines innovative mouse models for transient gene silencing multiplexed clonal analysis and molecular recorders of cellular states in sum memoristem will precisely define the origins mechanisms and physiologic consequences of hematopoietic memories thus allowing a conceptual leap forward in regenerative and stem cell biology harnessing the programming of stem cell memories may help in the development of in situ cell therapeutics to treat chronic inflammation aging and cancer
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cultivate crops with a fleet of electric agroecological robots that preserve the soils
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a growing portion of cultivated soils is suffering from severe compaction as a result of an intensive use of heavy thermal tractors and yet there is no alternative to these tractors and no other solution can deliver the same level of productivity whilst avoiding compaction and massive co2 emissions consequently soil productivity is declining threatening food production in the long term sabi agri develops the first collaborative electric agroecological equipment where a fleet of unmanned lightweight robotic vehicles follows a leader vehicle driven by the farmer to multiply work capacity whilst alleviating the ground pressure up to 15 times compared to thermal tractors this fleet named swarm is co2 emission free it implements agroecological practices in various crops for any type of soilcultivation task this is a first timersabi agri will scaleup the collaborative robotic technology and industrialize the swarm before market uptake in the eu and the us
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computational mechanisms of teacherpupil knowledge transfer
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teaching is one of the most complex and efficient forms for social learning as it largely mitigates the costs of individual learning through the capitalization of others experiences however while recent efforts have shed considerable light into how human learning is computationally modeled very little is known about how human teaching can be computationally implemented in the context of goaldirected behaviours compteach is an innovative research program conceived to bridge this gap by combining cuttingedge methods in cognitive science experimental and social psychology with stateoftheart techniques from reinforcement learning rl and natural language processing nlp it aims at understanding the computational makeup of pedagogical knowledge transfer between experienced learners teachers and novel naive learners pupils compteach will first identify actors choice strategies as indexed by model parameters and evaluate the extent to which pedagogical texts crafted by teachers and addressed to pupils lead to meaningful parameter correlations between the two secondly the action will implementnlp tools to identify how the teachers own computational strategies are encoded in the semantic and syntactic structures of pedagogical texts finally the project will study how the teachers own learning process and metacognitive features affect knowledge transfer by tackling teaching from a computational perspective without losing sight of its sociocognitive underpinnings compteach will produce a novel quantitative understanding of experience transfer and establish novel bridges between teaching cognitive science social psychology and computational modeling future directions of this project will involve studying knowledge transfer in individuals afflicted by lasting underlying health conditions and the development of ecological experiments to approach teacherstudent and doctorpatient realworld interactions
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mitochondriaer communication by contact sites during plant stress responses
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it is common knowledge that an ethernet connection is safer than a wireless connection and cellular organelles share this approach to communicate directly among each other organelles are thought to use membrane contact sites mcs the optical fibers at the intracellular level organelles are in a prime position to sense and communicate stress signals due to their tight integration into the cells metabolic networks interorganelle communication is thus crucial to pass on the message to coordinate cellular stress responses and maintain homeostasis i hypothesise that mcs allow fast and efficient communication of stress signals between intracellular organelles eg mitochondria and er to coordinate the cellular stress responses however the organelle tethering proteins the stimuli driving mcs formation and the signalling molecules mediated through these mcs remain elusive in plants in intercom i will characterise ermitochondria communication in response to stress in arabidopsis thaliana for that i will leverage the host labs previously established ermitochondria communication model system and establish a proteomic screening setup to identify novel proteins involved in ermitochondria mcs in plants in addition i will develop a highthroughput platform to study interorganelle interactions in vivo and to identify stimuli driving mcs dynamics finally i will employ genetically encoded biosensors to pinpoint ros and calcium interorganelle signalling events to reach my goal i will combine my expertise in intracellular signalling and bioimaging with cuttingedge interactomics livecell imaging and highcontent technologies available at the host institute this innovative and interdisciplinary approach will allow me to shed light on plant interorganelle communication a field still in its infancy in plant biology with the potential to pave the path for the biotechnological engineering of plants more resilient to harmful environmental conditions
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tests and applications of a peripheral interference theory of reading
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reading ability is essential in modern society yet for many people it comes with considerable difficulty and to cognition scientists it remains rather mysterioushere i outline a plan for testing and applying a novel cognitive theory of reading the plan expands my recent model pong snell 2024 psych rev with a groundbreaking perspective on visuospatial attention to capture many reading behaviours wp1 the exciting prospect is that pong in a single stroke informs three big debates parallel processing wp2 positioncoding wp3 and peripheral interference wp4in wp2 a novel combination of eyetracking and eeg gazecontingent rapid invisible frequency tagging gcrift will provide a firstever direct window on the attentional distribution during readingit is konwn taht yuo cna raed tihs fnie but many readers also fail to see the error in do love you me the topic of word position coding is new to the field and pong predicts key roles for attention and statistical learning herein wp3 uses gcrift to track their relative contributions in time and space propelling a firstever unifying account of letter and word position codingpong predicts that letter and word recognition is hindered by surrounding text and possibly this is more severe in dyslexic readers wp4 tests pongs new account of dyslexia in which diffuse attention plays a causal role an exciting element here is my new reading interface iris the interface that reduces interference using saliency readers view texts while their eyes are tracked fixated words are shown at a higher contrast than surrounding text preliminary results show strikingly faster reading upgraded iris will tune its parameters to individual readers on the basis of incoming oculomotor data this holds both theoretical and practical promise testing dyslexic and nondyslexic readers iris parameters will reveal reading profiles to inform specific treatments and to further bolster the pong theory
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fluorescent boroncluster dyes as biocompatible photosensitizers with promising antimicrobial and anticarcinogenic activity
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the increasing resistance of microorganisms bacteria virus fungi against antimicrobials and antiseptics is one of the most challenging topics in current medicine and biology statistics from the centre for disease control and prevention suggest that bacterial resistance to antibiotics causes over 20000 deaths every year in eu member states alone the european centre for disease prevention and control ecdc alerts that healthcareassociated infections caused mainly by multidrugresistant mdr bacteria remain a public health issue and emphasizes the importance and urgency to search for effective alternative approaches based on completely different mechanisms one of the promising approaches to fight against infections is the antimicrobial photodynamic therapy apdt using biocompatible photosensitizerscompared to classical antimicrobials the biggest advantage of apdt is the very low probability that the target microorganisms have the opportunity to develop resistance furthermore apdt can be synergistically combined with other antibacterial treatments such as radiotherapy antibiotic treatments and photothemal therapy to improve its antibacterial efficiency the main goal of this project is to engineer novel boron rich biocompatible photosensitizers with suppressed interactions and herewith enhanced for efficient singlete o2 production to be used in a twofold objective a as apdt agents for the inactivation of microorganisms in sanitary instruments and medical devices b as antitumor agents in dual pdtbnct cancer therapies the innovation is focused on the development boron content pss with multiple applications both for antimicrobial apdt and anticancer pdt and bnct
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quantum metamaterials with integrated atomiclike arrays for quantum information processing
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the key to realizing quantum systems that can implement quantum information processing is entanglement generation between many qubits for distributing entanglement strong interactions between localized qubits atoms and flying qubits photons have to be ensured the quantumscience community is currently searching for systems that offer enhanced lightmatter interaction as the efficiency of quantum operations in current stateoftheart systems is limited by the interaction strength and loss mechanisms which impede the generation of useful manybody entangled states we plan to address this challenge by creating quantum metamaterials from quantumemitter arrays as novel interfaces for generating atomphoton entanglement whereas most of the scientific effort focuses on coupling localized qubits to predesigned structures to enhance interaction ie cavities we plan to take a completely different approach building bottomup quantum optical metamaterials out of quantum particles we will achieve this by embedding siliconvacancycenter arrays integrated in a diamond chip which have shown to be top candidates for entanglement distributionwe will harness the enhanced collective response of the emitters to light and achieve a quantum response by coherently controlling the emitters internal degrees of freedom we will also access neverbeforeobserved longlived states which are ideal for quantum memory our vision is to implement a scalable quantum light source with many degrees of freedom that generates largescale atomphoton entanglement by employing quantum information protocols we developed our system can generate manybody entangled states applicable to oneway quantum computation our system unites major advantages for scalingup entanglement 1 highfidelity quantum control over photonic states 2 potential operationtime speedup by parallelizing photon control 3 quantum memory with longlived states 4 integration into nanophotonics
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toolkit for adaptable resilient installations securing high quality drinking water
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the revised eu drinking water directive promotes a risk assessment and risk management approach for securing drinking water supply in the context of climate change and increased pollution however this approach is challenged by insufficient information that is available to operators especially in real time on compounds and organisms of emerging concern such as pesticides pharmaceuticals disinfection byproducts heavy metals and pathogenic microorganisms we argue that if drinking water treatment could leverage novel technologies and design philosophies and more agile operational actions could be supported drinking water supply systems could become more adaptable and robust without expensive infrastructural investments in this context todrinq develops and tests a compendium of modular complementary innovative solutions the todrinq toolkit that provide new information and better support tools to operators and designers to adapt to short and longterm changes in water quality while obtaining high drinking water quality at the tap todrinq develops novel real time sensing and water quality monitoring technologies innovative treatment systems especially suitable for smallscalemodular adaptable treatment plants and interoperable decision tools that support resilient evidencebased treatment plant design and improved overall water system operational awareness and response the consortium is perfectly placed to achieve significant progress beyond the state of art based on a researchtechnology alliance of leading universities and research institutes and innovative technology developers including deep tech smes it is also ideally placed to maximise relevance and impact by grounding its innovations on diverse realworld cases through cocreation with five proactive water companies in the netherlands greece france switzerland and the czech republic and maximise outreach through the influential multistakeholder network water europe
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spacebased applications for transport monitoring and management
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spatra aims at increasing the use of satellite data in land transport by developing two demonstrators in new downstream applications for monitoring and management of rail and road transport spatra will use satellite with assisted insitu data to develop two innovative applications for smart transport and logistics to solve problems of principal modes of land transport road and rail road traffic congestions and negative impact of extreme temperatures on railway infrastructure spatra will provide benefits of satellitebased logistics and road traffic flow monitoring extended beyond improved efficiency by reducing congestion and improving the flow of goods and people a novel spacebased service predicting the risk of rail buckling based on downstream application for estimation of the rail temperature will be developed that can support rail management plan to prevent track buckling induced train derailments
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imination reactions mimicking reversible histone kptms
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nature makes use of covalent additions of functional groups to proteins for regulating essential processes like cellular signalling and protein foldingdegradation most of these posttranslational modifications ptms are enzymaticallyreversible with the coupled catalytic processes being fulfilled by antagonistic enzymes eg methylasedemethylase pair this dynamic behaviour allows for the correct metabolic equilibrium as an unbalanced ptmmachinery is indicative of some severe diseases such a complex autoregulated system is the result of millions of years of evolution that has allowed for highly efficient and siteselective functionalizations nevertheless selective covalent bond formation in a substrate with multiple competitive sites is an intricate endeavour in the absence of auxiliary enzymes or other sacrificial agents dynamic covalent chemistry could be a major asset for overcoming this research bottleneck as the reversible nature of the reactions involved can drive the functionalization to the most thermodynamically favoured sitemost proteins contain lys k residues with terminal amino groups suitable for derivatization in particular histone kptms are crucial for controlling gene expression with the most common modifications being acetylation and methylation the proposed work will explore the reversible modification of histones using aldehydes that contain within their structure the functional groups required for the recognition by biological readers for instance aldehydes with carboxylate and trimethylated ammonium groups will be examined to mimic naturally occurring ksuccinylation and ktrimethylation this approach is still unexploited due to the lability of imine bonds in physiological water however several important biological processes are governed by the formation of iminoiminium reversible bonds with pyridoxal5phosphate plp derivatives inferring that this sort of chemistry is possible in protein microenvironments
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federalism and border management in greek antiquity
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federation for peace in ancient greece is the title of a wellknown article published by jao larsen in 1944 classical philology 39 14562 as the world was being ravaged by war larsen wondered about the potential of federalism as a means of conflict resolution the subject of his study was federal organisations in a broad sense in ancient greece but the research clearly stemmed from a question that is today becoming increasingly topical can federal organisations limit or even eliminate intrafederal war the project febo federalism and border management in greek antiquity starts from the assumption that the question above which continues to be asked by scholars no longer makes sense despite romantic projections federalisation processes do not guarantee peaceful coexistence neither within the constituent federal organisations nor on their external borders this is true for both ancient greece and the contemporary world as far as ancient greece is concerned and perhaps not only ancient greece the question should focus rather on borders how did the greek federal states deal with the problem of internal intrafederal as well as external borders the aim of this project is to demonstrate that a greek federal states implemented precise border management policies
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connecting resonances a decolonial intervention into sound studies by listening to the global south
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the proposed project intends to create a fertile entry point into the history practice and aesthetics of sound media in south asia as a key area of the global south aiming to understand the unique auditory cultures and sonic sensibility of this underexplored area in the light of the transcultural confluence between global north and south such new knowledge fundamentally shifts the perspectives in sound studies and in a global media art history with a decolonial approach of colistening and exploring medial reciprocity mentored by leading sound scholar and theorist prof brandon labelle at the university of bergen and working with other institutional partners in norway and internationally the project reexamines a fundamental issue in the studies of modernity and globalisation concerned with media cultural encounters and technological transmissions between global north and south as a twoway process of postcolonial confluence the project is a first of its kind to research an ignored area of sound studies by putting south asian sound and media scholars artists and practitioners on the international platform making their work exposed to the wider global audience for a muchneeded critical engagement and equity in scholarship the project benefits the large pool of practitioners active in south asia whose work has often been neglected in the eurocentric field of critical media studies and media art history the project makes a sustained attempt to assess their work toward a new decolonial theory of sound media in the form of a book and other outputs aiming to address a number of critical issues in sound studies
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covalent chiral functionalization of graphite for enantioselective applications
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an object or a molecule is said to be chiral if it can be distinguished from its mirror image chirality plays an important role in many areas of chemistry biology and physics many chemical processes involving solid surfaces such as catalysis crystallization adsorption and so forth are sensitive to chirality thus surfaces are not fertile playground studying chirality but they can also be used to promote the separation of mirrorimage molecules ie enantiomers due to additional constraints created by the twodimensional 2d environment because of the reduced symmetry at the interface these constraints enhance the expression of molecular chirality allowing not only chiral molecules but also prochiral molecules to produce chiral superstructures even so recognition processes based on noncovalent interactions could be used to separate enantiomorphs in 2d systems this new method could be used to resolve racemic mixtures in this project nanoconfinement conditions created using scanning probe nanolithography will reveal how the shape and size of the confinement as well as the nanolithography process itself affect the chirality of onsurface crystallization processes robust chiral surfaces will be created using covalent functionalization of graphite and applied for enantioselective separation also bulk chiral graphitic materials will be synthesized and used as stationary phase in chiral chromatography surfchir will allow me to pursue a highly innovative research line in surface science providing me a perfect platform for my personal development in terms of research and training in a topic of key importance ie chirality and statetotheart imaging techniques this project will also allow me to strengthen my teamworking and leadership skills as well as widen my scientific network and collaborations in summary this msca grant will be a positive turning point in my academic career towards scientific excellence
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towards a sociology of loss disposals and deadends in lineages of social innovation and change
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this study aims to provide a new understanding of how losses disposals and deadends shape the direction of social change at moments of rupture and to develop a formal theory of social loss sociologists have shown that people respond to crises by reconfiguring cultural understandings narratives of self and social relationships however we have not paid sufficient attention to how what is disposed of shapes future pathways linloss will address this gap in the sociological imagination it will develop new explanations of how loss generates change at multiple intersecting societal scales in the transformation of cultural and institutional patterns across generations within changing configurations of relationships across genealogies and social networks and in the reconstruction of pasts and futures within biographies the research will be a comparative crossnational community study of two exurban districts in ireland and poland the main form of data collection will be mixed biographical interviews combining unstructured and formal elements connected within genealogical support networks the analysis will take place across two iterations a comparative analysis to trace the effects of breaks and losses within and between social lineages at multiple scales and a thematic analysis to identify how instances of loss are tied together by a common social pattern we live in unsettled times when it is essential that sociologists provide insights on how pathways of social loss and renewal lead to variations and resilience to new challenges for individuals families and communities if successful the study will make a significant contribution towards this goal it will deliver a methodological breakthrough in pioneering methods for the analysis of dynamic multiscalar social processes and will make a major theoretical contribution to scholarship on social change
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foundations of algorithmic contract theory
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algorithmic game theory agt lies at the intersection of algorithms and incentives offering a framework for the design of algorithms that provide incentives for collaboration in computational markets agt has played a pivotal role in shaping vital computing platforms one of the most influential fields within agt is algorithmic mechanism design providing incentives for truthful revelation of private informationan equally important intersection of algorithms and incentives arises in the design of algorithms incentivizing selfinterested agents to exert costly effort in executing their tasks incentivizing effort was studied with great success in the economics field of contract theoryas classic applications of effort incentivization move to computational platforms including huge computational markets for freelancing services marketing and online courses they grow in scale and complexity and become datadriven in this evolving landscape adopting an algorithmic approach to contract design is essential this includes a language for analyzing the computational complexity of contracts in combinatorial settings tools for studying simplicityoptimality tradeoffs and a formalism for analyzing datadriven contractsin 2006 i coauthored the pioneering paper applying an algorithmic lens to contract design marking the inception of the field of algorithmic contract theory act and foreshadowed future developments however it is only in recent years that the scientific landscape and computational platforms have matured to a stage where act has become a prominent field in agt preliminary research in act has been enlightening however the state of the art of act still lags far behind full applicability in internet applications largely due to disregard of crucial realworld aspects the paramount goal of this project is to establish a foundational theory for algorithmic contract design that will bridge this gap and inform the design of realworld applications
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tools for the identification of anthropic fire in low visibility contexts during the middle pleistocene
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the use of fire is an element that characterizes the genus homo and one of the technologies that more substantially modifies prehistoric life systems nevertheless the oldest evidences of fire are often more controversial and difficult to identify the firetools project address the habitual use of fire in two peninsular archaeological sites with indirect evidence of fire in their levels and dated between the 400300ky sima del elefante atapuerca spain and la cansaladeta la riba spain this geographical and chronological range has been carefully selected the iberian peninsula provides the ecological conditions wood availability for the use of fire throughout the pleistocene and the habitual use of fire is stipulated as the most accepted hypothesis during this period firetools project aims to apply a crosscutting approach integrating archaeobotanical phytoliths and chemical analytical polycyclic aromatic hydrocarbons procedures in these two case studies to improve the analytical capacity to identify and characterize the pyroarchaeological record with low visibility furthermore the project will create a widen and complete modern reference collection of phytoliths from woody plants as an important analytical tool to address the pyroarchaeological record in paleolithic sites additionally the firetools project will evaluate the integration between the analysis of archaeobotanical microrremains and chemical elements with the archaeological data available from each archaeological site the expected results of the methodological proposal seek to be of further application in other archaeological and chronocultural contexts with the presence of fire in sum the results of this project will allow knowing the relationship that the hominids of the middle pleistocene had with fire in the context of iberia validating a methodological and analytical approach to study the fire record across prehistory
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pahadvance accelerating the clinical path of ntp42 a diseasemodifying drug that will disrupt the future treatment of cardiopulmonary diseases including pulmonary arterial hypertension pah
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atxa therapeutics has developed ntp42 a disruptive new drug for pulmonary arterial hypertension pah and related cardiopulmonary heart lung diseases ntp42 blocks the thromboxane receptor a target at the root cause of pah related diseases by treating all clinical hallmarks in both the lungs and heart ntp42 offers a gamechanging solution for pah leading to its rapid adoption once marketed atxas phase i clinical trial showed ntp42 is safe highly efficacious in manwith eic blended finance and vc coinvestment atxa will undertake a phase ii trial on ntp42 in pah we will then secure a licensing deal with a pharma to accelerate ntp42 to the pah market sales 1b at 5 yrs postlaunch royalty returns to atxa with the proceeds of the licensing deal we will diversify uses of ntp42pipeline drugs to treat other priority target diseases this will also enable growth 100 ftes transforming atxa into a major european pharma with a diversified diseases drugs portfolio
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efficient zeroemissions gas turbine power system for maritime transport
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the transition of the waterborne fleet to a zeroemission mode of transport critically depends on the development of power conversion systems that effectively can use sustainable alternative fuels going beyond the stateoftheart in gas turbine technology marpower will deliver a highly efficient system endowed with an intercooled recuperative twoshaft gas turbine with a bottoming cycle the modularity and versatility of the system is a unique function and provides its own competitive benefit it is designed for flexible use of neutral green methane green methanol and zeroemissions hydrogen ammonia fuels and it can reach up to 5055 electrical efficiency and 7376 overall electricalthermal efficiency in this sense it can be operated to optimise the electrical power generation onboard a ship but also to be operated in combined heat and power chp mode both modes will be assessed through two case studiesmarpower will optimise the design of the turbomachinery components which are essential and specifically conceived for using zeroemission fuels accordingly it will develop a new fuelflexible combustion concept in which the combustor will be able to run on 100 hydrogen or other neutral or zeroemission fuels without any additional changes to the combustion system high efficiencies will be additionally fostered by the integration of an active magnetic bearings amb technology for control of long highspeed shafts the impacts generated from marpower will allow the creation of a value chain for the construction and deployment of the energy conversion system in different types of ships worldwide achieving significant economic social and environmental impacts and therefore boosting european leadership in the maritime sector the project can contribute significantly to the decarbonisation of the maritime sector avoiding the emission of more than 23 million of tonnes of co2 into the atmosphere
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recycling electronic waste to catalyse h2 production and co2 reduction using recovered metals a step towards circular economy
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this proposal combines physical science research with metallurgical process design and engineering to promote positive change in the electronic waste ewaste industries and create economic and societal benefits for the world we undertake coordination and supramolecular chemistry research to understand and develop reagents for ewaste metal separations integrate this insight into practicable solutions for ewaste recycling and translate research outputs into innovation for the ewaste industry in a sustainable way we utilize the recovered precious metals from ewaste to develop catalysts for hydrogen evolution and co2 reduction through electrochemistry hence the proposal targets three key agenda of the horizon europe framework programme and the united nations sustainability goals ie circular economy sustainable energy and environment
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blinkin visual assistance defining a new category of automated visual support towards to a visual ai operating system for europe not sirialexa our moonshot is to give the world a help button
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blinkin develops a platform to enable the next generation of tech support tech support is with blinkin visual and automatedblinkin enables enterprises to create digital assistants for smart devices that guide people interactively through firsttime setups troubleshooting and maintenance our visualbots will analyse a problem using computer vision interpret the situations through aiml recommendations and guide through a visual resolution interactively using augmented reality with its nocode platform we will build an open european ecosystem where contributors can create build and sell visual skills to deliver learning models for endusers to simply resolve a problem with their smartphones our moonshot is to give the world a help button we define a new category of automated visual support with market potential way beyond the standard audio or chatbots assistant towards a visual ai operating system as a european counter force to other assistants ie sirialexabixby
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menstrual migraine understanding its pathophysiology and developing precision treatment strategies
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females experience 3 times more migraine attacks than males with menstrual migraine affecting 60 of these females they occur before or during menses and are associated with oestrogen e2 withdrawal dramatically affecting a patients quality of life menstrual migraines are poorly understood limiting novel treatment strategy discovery recently i demonstrated that e2 withdrawal increases the function and forward membrane trafficking of specific potassium channels kv7 in systemic arteries if present within the cerebrovascular system e2 withdrawal will increase sensitivity to endogenous migraineinducing vasodilators such as calcitonin generelated peptide cgrp contributing to migraine onsetthis project is split into two objectives 1 investigate oestrus cycledependent changes in rodent cerebrovascular reactivity via molecular functional and electrophysiological techniques with a focus on e2 mediated changes in kv7 subcellular trafficking via novel gprotein coupled oestrogen receptor gper1 2 translate preclinical basic science research generated in objective 1 into a model of mensural migraine international collaboration with prof geoffrey abbott at the university of california irvine allows for access to in vivo hemodynamic perturbation monitoring hpm and a novel crisprcas9 kv7 knockout rat hpm allows for simultaneous measurement of cerebral blood flow and migraine onset induced by cgrp we will investigating if female rats are more susceptible to migraine induction when e2 is low and and whether they are protected from migraine induction by gper1 stimulation or kv7 knockoutour project has the potential to reveal novel pathophysiological mechanisms underlying menstrual migraine allowing the development of novel precision treatment strategies my hosts and i are experts in the field of vascular kv7 physiology and are the ideal candidates to carry out this project
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robust simulation systems exploiting ai based turbulence models and hightfidelity algorithms
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to meet global eu objectives related to aeronautical industry competitiveness and climateneutrality highly advanced design technologies are needed to allow fast and reliable evaluations of innovative configurations rosas aims at exploiting artificial intelligence aimachine learning ml coupled with recent advances in computational fluid dynamics cfd technology and the underlying turbulence modelling to reduce expensive and timeconsuming physical testing and drastically accelerate the whole design optimization processpartners will build a methodology based on defining test cases targeting the key flow problems encountered in industrial applications and reproducing them precisely in a controlled environment via hifi simulations or experiments the results will be gathered in a database which will serve the development and testing of novel datadriven methodologies aiml and mesh generation algorithms improved turbulence models including multifidelity surrogate models with advanced verification and validation process will be created with modifications based on new theoretical considerations and aimlbased modifications resulting in hybridization of specific turbulence models in addition application challenge test cases will be defined in relation to clean aviation applications to match closely industrial configurations of interest to assess and demonstrate the new methodologies developed in the projectrosas brings together 14 partners from 8 eu countries and 1 from uk the consortium comprises 4 leading research organizations 5 leading university groups a supercomputing centre and 3 major aeronautical industries all partners will bring their innovativeness infrastructures and long experience in design and aerodynamics modelling ensuring industrial exploitation of results by exploring new aircraft and engine concepts more effectively 1 sme will bring experience in project management communication and exploitation
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biomarker research and evaluation for clinical implementation and supporting systems enhancement
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brecise is a publicprivate partnership project cofunded by the innovative health initiative ihi of the european commission aiming at creating a collaborative ecosystem to accelerate the clinical validation of nextgeneration sequencing ngsbased multimodality artificial intelligence ai oncology biomarkers and related technologies by addressing technical and regulatory challenges the consortium unites diverse expertise and resources to validate novel prostate and bladder cancer biomarkers ensuring their efficacy and clinical utility this initiative aligns with the goal of advancing precision medicine in oncology ultimately improving patient outcomes and streamlining personalized cancer carebrecises primary objective is to enhance biomarkerdriven approaches for patient risk stratification disease progression prediction and treatment response assessment within the framework of precision medicine the project addresses the current challenge of limited access to clinically validated prognostic and predictive biomarkers in oncology by providing healthcare professionals with ngsbased multimodality ai oncology biomarkers brecise aims to enable precise disease risk assessment and informed treatment selection contributing to more personalized and effective patient carethe impact of brecise is transformative aiming to revolutionize risk assessment and treatment selection in oncology facilitating the implementation of precision medicine this will significantly reduce unnecessary and ineffective treatments optimizing patient care and minimizing side effects the validated biomarker technologies empower researchers to develop safer and more effective personalized treatments advancing precision medicine these advancements will enhance the competitiveness of european health industries positioning them at the forefront of innovation and healthcare excellence overall brecise is expected to significantly improve patient outcomes enhance healthcare efficiency and bolster the global standing of european health industries
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fighting pandemics from below global northsouth public health cooperation in the middle east and north africa 17921942
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this project will recapture the lost archives and historical knowledge of international public health cooperation between the global north and the global south by analysing its first and longestlasting instances the sanitary councils in the middle east and north africa mena established in tangier alexandria tunis istanbul and tehran these unprecedented institutions strategised against waves of epidemics and pandemics between the 1790s and the 1940s their european american and native cofounders invented new models for fighting pandemics from below and stopping the diseases in their tracks they continually strove to overcome the familiar barriers to cooperation posed by interimperial competition in a multipolar world economic inequities protests against quarantine restrictions and racial and orientalist biases among others in this light the councils constituted the microcosms of the complex dynamics of northsouth health cooperation that also need to be addressed urgently today however to date there has been no indepth comparative and longitudinal analysis of their workings this project will challenge the mainstream narratives by writing an entangled rather than westcentric history of health cooperation and by shifting the focus from topdown to bottomup processes it will determine what the preconditions for effective international public health cooperation in mena were and hypothesise that rather than great power imposition or veiled imperialism alone multifaceted reciprocal action induced and sustained sanitary internationalism on the ground my preliminary data show that the agency of local actors and smaller and medium european powers in accrediting public health cooperation was more central than has been documented to date this research will test my hypothesis by examining the councils activity performance legitimacy and endurance and by consulting archival sources in europe mena north america and russia
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lasers for accelerated netzero transition
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approximate 30 of the emissions of evehicles comes from the manufacturing processes due to unoptimised material utilisation low process efficiency product defects and wastecurrent stateoftheart identifies laser material processing technologies the heart of evehicles manufacturing advances in laser technologies and new generation scanning optics in fuel cell and battery manufacturing have the potential to offer enhanced utilisation of materials improved process efficiency and product quality allowing significant reduction in co2 equivalent lasers4netzero will establish an innovative training programme that aims at coaching a new generation of creative entrepreneurial and innovative doctoral candidates phds focused on laser material processing artificial intelligence for quality control advanced process simulation and predictive lifecycle and sustainability analysis for evehicles manufacturing this novel programme will contain both scientific and transferable training activities and will benefit from training across the network eg secondments in total 10 phds will be enrolled developing individual research projects within the project individual phd projects will integrate novel methods and approaches for laser material processing cutting and welding aided by laser beam shaping and ultrafast scanning technologies with the ultimate goal to enhance utilisation of materials improve process efficiency and product quality and reduce defects and waste the consortium involves 6 academic partners and 8 industrial partners guaranteeing that final solutions will be close to the market the close cooperation among multidisciplinary partners will ensure knowledge transfer to cross the valleyofdeath between research and implementation to maximise impact two demonstrators fuel cells and battery systems will be developed in conjunction with the industrial partners
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disrupting buddhist circular economies excess and abandonment in contemporary japan
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antimaterialism is the most pervasive popular assumption about buddhism that obscures buddhisms material presence and its environmental impacts problematising such moulds this ethnographic project will demonstrate how buddhist materiality drives buddhist circular economies rooted in practices of meritmaking and inherited ritual labour by tracing buddhist objects biographies and illuminating the circular nature of buddhist material exchanges i investigate how things given to local temples generate excess and abandonment practices in contemporary postgrowth japan through histories of these objects and their relations i uncover how demographic hyperageing regional depopulation and changing consumption patterns inform and disrupt buddhist material exchanges how family altars and other personal ritual items as well as meritorious food land and object donations get caught up in discard disposal and reuse cycles and what emotional ethical practical and spiritual implications ensue as such i will illuminate how buddhist practices for processing accumulation and abandonment of buddhist gifts are key to understanding contemporary buddhism and the wider issues of consumption recycling and aspirational nonwaste economies they inhabit i will therefore consider buddhist giving as forces that generate and handle excessabandonment that challenge the viability of the circular economy ideal by producing waste global concern about waste continues to rise this research interrogates the wastemaking impacts of religious activity and assesseses the spiritual and practical implications of managing religious excess in the worlds fastest ageing society it complements and is complemented by the research at the university of copenhagens center for contemporary buddhist studies interrogating buddhist economic entanglements and waste that is created by buddhist economic exchanges thus supporting my development as an expert within this critical field
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european recycling and circularity in large composite components
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eurecomp aims to provide sustainable methods towards recycling and reuse of composite materials coming from components used in various industries such as aeronautics and wind energy the main pathways to achieve circularity will include i repairing repurposing and redesigning parts from endoflife large scale products and ii recycling and reclamation of the materials used in such parts thus accomplishing reduction of waste and transformation to highadded value products
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repurposing of cast systems as nextgeneration tools for genome engineering of mammalian cells
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genome editing using rnaguided crisprcas nucleases clustered regularly interspaced short palindromic repeats that associate with crispr associated proteins has radically altered life sciences enabling genome manipulation in living organisms however their use is limited by dependence on dna damage response ddr which restricts genome editing to dividing cells further these nucleases cannot handle dna cargos large enough to harbour regulatory dna circuitry thus precluding genome engineering in intetools i will overcome these limitations by dissecting and repurposing crispr associated transposon cast systems into genome engineering tools casts are naturally occurring prokaryotic proteinrna machineries consisting of an inactive crispr effector complex which associate with tn7 family transposons to insert large dna cargos knowledge of their molecular mechanisms is scarce which prevents their practical application in genome engineering accordingly in objective 1 i will investigate the architecture of different casts to obtain fundamental knowledge of their rnaguided integration i will then use this knowledge in objective 2 to dissect their mechanism underpinnings whereby crisprcas complexes associate with transposition complexes to insert with nucleotide accuracy dna cargos this will inform objective 3 where i will design new cast tools that will allow rnaguided transposition in eukaryotic genomes these revamped casts will be capable of inserting large dnas with high precision harbouring regulatory regions into eukaryotic genomes enabling genome engineering in eukaryotes i will test the redesigned casts in mammalian cell lines and at the organismal level by rescuing the eyeless mutant phenotype in drosophila melanogaster intetools will catalyse a conceptual leap propelling the field into a new era of genome engineering with major biomedical and biotechnological applications especially in synthetic biology
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capturing identity change and the long tail in knowledge graphs
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at first blush entities and concepts such as dutch east india company or coffee may seem straightforward but in fact they are complex and multifaceted the wealth of digital sources presents the massive potential to study these notions at an unprecedented scale however current technologies for distant reading are not capable of dealing with thistrifecta aims to create a database that describes complex entities and concepts and their contexts by combining language and semantic web technology to extract and relate information from different texts over time in addition a key aim of trifecta is to advance the state of the art in these technologies to deal with change over time and connections to many different narratives sophisticated knowledge representation methods from the semantic web can mitigate the failing that many language technology methods do not incorporate enough background knowledge to recognise and interpret complex entities and concepts in their historical contexts by treating them as rich networks or graphs of knowledge that can express change and relationships to different concepts in space and time semantic databases can handle the complexity needed to make the outputs of language technology tools suited to humanities research via two use cases i identify a set of core contentious entities and concepts in maritime and food history next through a datadriven iterative approach i advance beyond the stateoftheart in natural language technology for the humanities by targeting three key aspects of the recognition and modelling of complex concepts ie identity change and the long tail i propose a novel peerevaluation approach in which a team of humanities scholars computational linguists and semantic web researchers collaborate closely to create truly hybrid artificial intelligence systems that will enable humanities research to scale to big data without losing sight of the contextual complexity
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fundamental advances for the fire safety of tall timber structures including the fire decay phase
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urban densification sustainability drivers and technological advances foster the development of highrise structures using biobased materials like engineered wood products their main worldwide barrier relates to fire safety although a natural fire has a decay phase structural capacity is traditionally assessed according to a standard fire curve an unrealistic everincreasing thermal exposure with time conceived as worstcase design scenario this results in inadequate assessment for timber often disqualifying it as potential material also the decay phase deemed less onerous due to its lower temperatures is generally omitted from structural calculations however for structural performance it is of crucial importance for timber unlike traditional noncombustible construction materials wood loses its mechanical properties at relatively low temperatures thus the precise interaction between fire and structure needs to be understood because the temperature propagation through the loadbearing timber can unexpectedly lead to structural collapse even after a fire seems extinguished current regulations fail to consider this hazardous issue and available literature on the matter is limited fundamental technical issues still need to be resolved and pertain to the nature of the fire dynamics and the resulting deterioration of the engineered timber mechanical properties in firesafetimber computational models are built to simulate the thermal exposure to structural elements for various fire dynamics conditions eg fuel and compartment characteristics benchscale and fullscale fire tests are conducted on loaded timber structural elements with varying fire decay phase firesafetimber will formulate a novel constitutive model to predict the heat transfer and the structural capacity of timber elements and will develop performancebased methodologies for the firesafe design of timber structural systems that include the effects of the fire decay phase
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multicomponent interventions to reducing unhealthy diets and physical inactivity among adolescents in subsaharan africa
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the fragile health systems in urban subsaharan africa ssa are already overwhelmed with ncds despite this the implementation of the evidencebased who best buys policies for ncds prevention in the african region has been found to be offtrack additionally less attention has been given to adolescents and yet this is a period in life where behavioural patterns of ncds risk factors are established and track into adulthood there is also a gap in our understanding on how to implement and scale up effective diet and physical activity interventions in real world settings in ssaour project therefore aims to reduce two important modifiable risk factors for ncds unhealthy diets and physical inactivity and their underlying social determinants among adolescents aged 1019 years living in mixed socioeconomic urban communities in two ssa countries ghana kenya by designing deploying and evaluating strategies for implementation of evidenced and theory based interventions mapped on to the who best buys we selected the two countries because they represent different cultural contexts of nutrition transition east and west africa and both countries are undergoing rapid economic development urbanisation and increases in ncd prevalence the intervention delivery will take a multisectoral approach to increasing the capability opportunity and motivation of adolescents to eat healthier and be more physically active we will focus on three settings to enhance the reach secondary schools and familycommunityfaithbased settings and the digital environment using social media together this project will increase opportunities awareness knowledge and health literacy motivate adolescents to increase selfefficacy guide selfregulatory actions and adopt positive health behaviour such as dissuasion from physical inactivity and sedentary behaviours or unhealthy food choices to prevent ncds
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multidimensional transition pathway analysis for sustainable futures exploring alternative paradigms and broadening policy options through innovative scenario development
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multifutures systematically broadens the scope for policy action towards sustainable societies by assessing and developing transition scenarios based on alternative economic paradigms this involves extending established transition scenarios eg the ecs long term strategic vision scenarios or the ieas net zero scenarios to include alternative economic paradigms that are based on a wide spectrum of sound economic and social theories and have demonstrated potential to address global challenges these paradigms introduce new policy options and instruments which we aim to critically assess regarding their relevance effectiveness and potential tradeoffs the project will proceed through four main steps first we use stateoftheart ai language tools and qualitative methods to map alternative paradigms and develop a paradigm taxonomy second desired futures are extended into quantified transition scenarios using a set of beyond gdp indicators to assess the potential for achieving a climateneutral just and resilient society thirdly stakeholder engagement through anticipatory systems mapping and social simulations will be used to cocreate alternative futures and develop concrete policies that balance tradeoffs mitigate negative impacts and enable dissemination and implementation in addition a largescale survey of 18000 citizens in europe provides insights into public perception and acceptance of alternative paradigms and transition policies fourth stateoftheart modelling will be integrated to assess the economic environmental technological and social impacts of alternative paradigms and policies from a wellbeing perspective including their environmental and social justice implications ultimately multifutures provides policymakers with a comprehensive understanding of alternative paradigms and a broader range of policy options to accelerate progress towards a climateneutral just and resilient society
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reionization and signatures of early stars
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understanding how the first stars and galaxies formed and drove the universes final phase transition by reionizing intergalactic hydrogen is one of the longstanding goals of extragalactic astronomy in the past two decades we have discovered this epoch of reionization ended around one billion years after the big bang redshift z 6 but the process is still poorly understood we are currently undergoing a radical shift in our ability to observe this epoch with the new james webb space telescope jwst early jwst observations have discovered a surprising excess of luminous z 9 galaxies implying stars may have formed differently in the early universe than we had previously expected however we can only observe the brightest galaxies directly enhanced star formationin the bulk of the early galaxy population should have produced an early start to reionization but this is stillvery poorly constrained observationally excitingly jwst finally enables us to chart reionization out to itsearliest stages and infer the properties of the first starsin rises i propose to analyse groundbreaking new datasets i am accruing as pi on jwst with stateoftheart statistical inference frameworks to connect observations of the bright galaxies visible with jwst to the evolution of the intergalactic mediumthe key aims of this proposal are to 1 test what drove the enhancement of star formation in the first bright galaxies 2 establish when reionization began to infer whether star formation was enhanced in the bulk of early galaxies and 3 understand how reionization proceeded by connecting galaxies to ionized regions for the first timethese measurements will push the boundaries of our knowledge of structure formation in the early universe and enable potential breakthroughs in our understanding of the formation of the first galaxies the regulation of star formation at the highest redshifts and the evolution of the intergalactic medium
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social prescribing to promote and improve access to health and care services for people in vulnerable situations in europe
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social prescribing sp is an innovative solution to bridging the gap between primary health care and nonclinical supports and services within the community sp enables general practitioners who identify healthrelated social problems to refer patients to a socalled link worker the link worker provides personalized support and helps these patients to access community resources by addressing any barriers that may exist sp is an approach to integrate health and social care and strengthen community orientation sp thereby mitigates the effects of social determinants of health on health outcomes however sp has not been tailored to the needs of people in vulnerable situations yet and the effectiveness of sp to improve their access to health and care services remains unknownthe overall objective of speu is to assess the potential of sp to promote and improve access to health and care services for people in vulnerable situations focusing on three primary target groups lgbtiq persons refugees and firstgeneration immigrants and older adults living alonespeu follows a mixedmethods approach sp adaptations will be cocreated with the target groups to adapt them to their specific needs and social contexts a pragmatic randomized controlled trial will assess the effectiveness of the adapted sp to improve access by randomizing 1776 patients in eight eu countries to receive sp or care as usual a qualitative analysis in five european countries will explore enabling and limiting factors to the implementation of sp from different stakeholders perspectives additionally we will communicate and disseminate results and translate them into policy actionspeu will enable health care systems to implement sp as a scalable safe costeffective and peoplecentred solution to provide equal access to sustainable care thus speu will enable the transformation of european health care systems to equitable communitybased peoplecentred and integrated health care
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countering oppositional political extremism through attuned dialogue track attune limit
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oppattune tracks the evolution of oppositional extreme ideologies and protectionist decisionmaking develops an innovative attunement model and tests a series of interventions at the national and transnational levels which limit the spread of extremism oppattune revitalises trust in key democratic institutions its actions involve an online iattune selftest interactive to build democratic capacity across diverse publics oppattune will create an oppattune summer academy for students and researchers 2025 and an oppattune winter academy for practitioners and policymakers 2026 oppattune provides micro meso and macro level evidencebased recommendations and strategies designed to counter the potential of extreme narratives to disrupt democratic growth it delivers this via a multidisciplinary consortium of 17 countries across the eu and its peripherydemocracies and the european project are under threat by extremism and lack of political and social dialogue existential insecurities arising out of economic and refugeerelated crises have been exacerbated by covid19 to create rebordering eg xenophobicnationalism and reshoring eg the localisation of production oppositional worldviews narratives and dissensus within public debate are all vital to a functioning democracy however destructive polarisation of oppositional usthem logic is at the core of the rise of extremist narratives disruptive actors polarise oppositional logic using disinformation emotions hot cognitions conspiracy theories and mistrust to create new forms of direct action this direct action is understood to many as direct democracy this direct action cultivates unlikely coalitions creating attractive alternative onlineoffline worlds which spread extreme narratives into the mainstream via deep rooted sociological and historical pathways oppattune will track attune and limit extreme narratives to foreground eu transnational freedoms and multilateralism
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the role of palmitoylation erasers in cancer metastasis
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metastasis is the major cause of death in patients with cancer a better understanding of the mechanisms driving metastasis is critical to develop more effective anticancer treatments the fatty acid palmitate has been recently identified as fuel for metastasispromoting pathways however why palmitate has such a unique prometastatic effect compared to other fatty acids with similar metabolic fates remains elusive strikingly i discovered that palmitoylation a reversible posttranslational protein modification driven solely by palmitate is essential for metastasizing breastcancer cells unexpectedly i found that palmitoylation erasers enzymes that remove the modification are essential to sustain prometastatic effects of palmitate during metastatic colonization therefore i hypothesize that in palmitaterich conditions eg under highfat diet palmitoylation anchor oncogenic proteins to membranes to get activated functioning as a priming event while erasers act as a ratelimiting release step allowing primed proteins to engage in prometastatic signaling i will investigate how the dynamics of palmitoylation promote metastasis by focusing on the erasers whose role in metastasis remains largely unexplored specifically i will 1 define how erasers influence prometastatic signaling events in metastasizing cells 2 investigate how erasers activity is regulated in metastasizing cells and 3 assess how organ microenvironments and palmitaterich diet condition eraser activity i will address this by integrating multiomics molecular biology and mass spectrometry techniques with clinically relevant in vivo metastasis models palmerasers will serve as a proof of concept for palmitoylationbased therapies with the goal of preventing or treating metastases by focusing on the influence of diet i will also enhance clinical translation of these findings by defining which patients will respond most effectively to palmitoylationbased therapies
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diving into the mineralogy and structure of exotic rocky exoplanets
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determining the diversity of exoplanets compositions and structure is fundamental for investigating the earths uniqueness the improvement of groundbased instruments and the launch of new space missions eg jwst is providing unprecedented information as to exoplanets masses radii and atmospheric speciation however none of these properties can uniquely constrain the nature of planetary interiors which dictate their geological evolution in order to interpret these new observations and identify future exoplanet targets the implementation of accurate interior models is required at present much of our knowledge on exoplanets interior comes from analogue experiments on earthlike compositions performed over pressuretemperaturecomposition spaces relevant for the solar system stellar data however has indicated a greater compositional diversity than in our own solar system thereby preventing an accurate description of the mineralogy and structure of orbiting planets exodivers aims to bridge the gap between astronomical observations and the interior properties of exoplanets by investigating the evolution of stable mineralogical assemblages for exotic compositions expected in exoplanetary cores and mantles with pressure and temperature the experimental bulk compositions will derive from spectroscopic data of observed host stars providing access to a compositional space that remains yet unstudied experiments will be performed to determine the stability of different minerals and refine their thermodynamic properties these new data will supplement existing databases and will be used to calculate the mantle and core mineralogy of exoplanets this novel approach obviates the earthcentric view of exoplanets mineralogy that has characterized the field up to this point and will be implemented to determine a priori how variations in the interior affect geological processes including the possibility of starting convection or activating a dynamo
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gaseous detectors for neutrino physics at the european spallation source
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the recent detection of the coherent elastic neutrinonucleus scattering cenns opens the possi bility of using neutrinos to explore physics beyond the standard model deploying small detectors however the cenns process generates signals at the few kev level requiring very sensitive detection technologies the european spallation source ess has been identified as an optimal source of low energy neutrinos offering an opportunity to explore at depth the physics of cenns with large discovery potential in this project i propose to apply the highpressure noble gas tpc technology to the detection of the cenns process at the ess this will require the detection techniques sensitive to very lowenergy depositions as well as improving the current knowledge of the quenching factor for nuclear recoils in xenon argon and neon gas at kev energies this project proposes the development of a novel detector able to hold 20 kg of xenon gas at high pressure the device will operate at the ess providing more than 7000 cenns events per year potentially overtaking the sensitivities of much larger detectors in current spallation sources operation with xenon will explore most of the possible new physics associated with the cenns process furthermore the high pressure technology offers the possibility to operate the same detector with different gases at minimal extra costs thus providing a unique tool to further explore any signatures of new physics at the ess
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nextgen of sustainable biobased chemical platforms and polymers enhancing sustainability in european industry
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successfully scaling up the sustainable and biodegradable materials is essential for the future growth of european industry to compete with wellestablished fossilbased chemicals biobased alternatives need to solve the triple equation of environmental safe economic and societal performance at the same time it must be economically viable on an industrial scale and possess properties akin or superior to existing petroleumderived analogues few biobased polymers have met this challenge nextstep will build on the h2020 biocatpolymers project to demonstrate a sustainable safe and economically viable production process for a new chemical platform with large scale applications notably in the biobased polymer market nextstep will use harwdood sugars produced from sustainably managed forest at the flagship plant of the project partner fibenol nextstep has defined ambitious kpis for its process regarding its economic performances as well as its biomass and energy efficiency the new chemical platform the 3methyldvalerolactone 3mdvl will improve the sustainability and recyclability of polyurethane pu products and unlock new engineering plastic applications for polylactic acid pla copolymers together with its derivate 3methyl 15pentanediol 3mpd the 3mdvl can also be used as a biobased polyol component in the traditional pu and other plastic production processesnextstep will demonstrate the applicability of its chemical platform by demonstrating its use as a feedstock for the production of i polylactic acid pla copolymers for shoe outsole and of ii recyclable non isocyanate polyurethane foams for shoe midsole and insulation materials applications five other applications will be selected for demonstration together with the polymer industry during the project
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scientific excellence in nanocatalysis at the heyrovsk institute
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the overall aim of the nanocat project is to boost scientific excellence in nanocatalysis at j heyrovsk institute of physical chemistry hipc by creating a consortium network with outstanding research institutions university ulm and vienna university of technology the consortium benefits from and fully utilizes complementary competencies both at the scientific and management level the partner institutions participate in joint research projects in the progressive field of physical chemistry namely nanocatalysis bringing together all expertise and approaches instrumental to achieving the scientific objectives by uniquely combining nanocatalysis synthesis surface science and electrochemistry from experiment to theory collaboration with respected experts enhances the visibility of hipc in the european context builds further scientific links and fosters the hipc integration into european research area aselfstanding activity is the creation of a european office at hipc the project structure comprises scientific exchanges of research staff empowering the performance of nanocatalysis science scientific exchanges of earlystage researchers esrs supporting equal opportunities and gender balance organization of communitybuilding events such as opening and concluding international conference in nanocatalysis reaching better visibility and increasing the profile of all partner institutions as well as organizing summer schools with esrs presenting their scientific achievements and gaining additional communication and soft skills dissemination and communication to target audience and project management structure guaranteeing smooth project implementation the project dedicates a specific attention to esr from the coordinator institution reflecting young researchers needs and encouraging ambitious challenging and international collaborative spirit
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building energy efficient system through short and long spectrum thermal energy storage
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buildings consume most of the worlds electricity and as much as 50 of their consumption is used to cover thermal demands some actual developments such as the growing use of electrical vehicles and the usage of heat pumps are affecting electricity consumption and peak demand and their impacts will only increase in the future the excessive high energy demand entails significant negative environmental and economic impacts consequently it is imperative to increase use of demand response strategies that shift electricity use from peak to offpeak periods the beststorage project is an important step to achieve the goal of peak load reduction and shifting energy saving and energy cost minimization moreover technologies for storing renewables for longer timespans of months or seasons are scarce and costly and thus not widely used yet large amounts of energy are needed for heat supply of buildings in cold winter months when solar energy is scarce and in general when renewable sources cannot cover the demand thus seasonal storage solutions will be a necessary technology for a full decarbonisation of the energy supply system in beststorage long and shortterm highenergy density storage solutions will be developed and demonstrated in four demo cases around europe a thermochemical and lossfree storage technology will be developed as a seasonal storage two phase change materials slurry concepts and a vacuum insulated water storage will be developed for cold and warm applications respectively with the aim of shifting peak load demands finally storage solutions will be integrated within smart building energy management systems featuring model predictive controls to reduce operation cost for shortterm applications
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singleatom catalysts for a new generation of chemical processes from fundamental understanding to interface engineering
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the grand challenge for the chemical industries of the 21st century is the transition to more sustainable manufacturing processes that efficiently use raw materials and eliminate waste catalysis engineering is the key enabling technology to drive this transition and singleatom catalysis is an emerging new approach to catalyst design however major questions concerning the local structure of these systems their reactivity and their evolution when prepared and structurally integrated into chemical devices are elusivethis project will address these important scientific gaps laying the foundation for a new generation of catalysts for co2 conversion to unveil their microscale functioning i will study for the first time the charge transfer taking place before during and after reactant adsorption and surface reactivity this will be done combining synthesis operando characterizations microkinetics and theoretical methods then merging microreactor technology and process intensification i will manufacture singleatom catalysts in powder and as miniaturized thin films or foams using new scalable and greener methods this will bypass current limitations in terms of efficiency and metal dispersion and close the gap on challenges related to catalystreactor integration bridging chemical and device engineering the materials will be validated in the valorization of co2 to derive structurefunction relationships and prove major catalytic improvements under realistic conditionsoverall this is a fundamental and interdisciplinary project with ambitious objectives and highriskhighgain potential that will go beyond the traditional pillars of catalysis the scientific outcomes will provide new perspectives in catalysis and open paths in other fields such as materials chemistry green synthesis and purification science my pioneering contributions in this field and new proofofconcept data place me in a unique position to undertake this fundamental study
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intelligent radiation sensor readout system
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the vision of irase is to pioneer a new class of radiation sensor systeminpackage sip chips at the intersection of computer science and neuroscienceoriented approaches to artificial intelligence ai developmentthe irase project aims to design build test and implement the first onthefly photonbyphoton radiation detector with transformational potential for various radiation applications such as medical imaging industrial inspection scientific space instrumentation environmental monitoring and morethe irase project will develop physicsinspired artificial neural networks anns for comprehensive sensor signal processing sp and realtime rt measurement of radiation interactions it will compact this technology into an ultimate vision for sp embedded in hardware hw as an allinone sip enabling cost and energyefficient detection and intelligent radiation data output with unparalleled accuracy and speed this approach enhances measurement precision and speed by utilizing complex sp event characterization and onthefly processing of incident radiationinduced signals in near realtime as a result it facilitates the retrieval of comprehensive information on incident radiation ultimately improving measurement accuracy and speed while reducing digital data output
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remote ethnography of xinjiang uyghur autonomous region methodology and research capacity building
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remote ethnography of xinjiang uyghur autonomous region methodology and research capacity building this project seeks to develop a methodology of remote ethnography to collect data and produce analysis of xinjiang uyghur autonomous region xuar in the central asian northwest corner of the peoples republic of china it aims to establish a consolidated research group train the researchers in methods relevant for remote ethnography and through their interactions develop both a remote ethnography of xuar and a sound methodology of remote ethnography for areas with limited access the motivation for this is that the developments in xuar and the abuse committed against the muslim minorities in the region have become major geopolitical issues central for the eu and european countries choices of future engagement and cooperation with china and the us at the same time access to xuar itself has become extremely limited and the information gained from the area often heavily politically biased fragmented and unreliable further the rise of surveillance securitisation and authoritarianism world wide suggest that such places will increase rather than decrease over the next decades it is therefore both important to gather reliable and deep knowledge of xuar and to develop solid methodological tools for approaching such closed state or privately controlled areas through this project palacky university olomouc upol along with the two partner universities würzburg universitt and universit libert bruxelles will become important interconnected hubs in a strengthening network of researchers on xuar will place upol on the map as a force in xuar studies and in methodological innovation of remote ethnography and will provide reliable information on the region to media policy makers ngos and other nonacademic stakeholders including the uyghur diaspora community to whom a degree of ownership of the knowledge produced about them and their region must be reinstated
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clear scalable and scientific framework to measure terrestrial biodiversity
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3bee applies technology to measure and regenerate ecosystem biodiversity using bees as sentinels we collect data through 3 assets hivetech iot sensor integrated in honey beehives to measure the health of a colony spectrum sensor for wildlife monitoring thanks to noises sampled and analysed throughout the year we monitor pollinators avifauna and insects in real time flora satellite data collection with the support of european space agency for agronomic analysis flora density flowering intensitythen we quantify a biodiversity index through a scientific methodology and select biodiversity regeneration projects proposed by the 4000 beekeepers and growers of our networkbiodiversity enhancement is measured through data on nectar potential honey production insects diversity and frequency and our pollination abundance index this enhancement is certified by means of a disciplinary protocol that follows iso standards elemente protocol and biodiversity credits are generated for establishing the benefits associated with regenerative techniques thanks to our technology and ai algorithms our methodology is scalable we can exploit data of an area where our inthefield sensors are installed to assess biodiversity in a much larger territoryour first customers are large corporations they have 4 why to buy esg reporting improvement improve transparency of the value chain improved brand positioning improved enps employee net promoter scoreby promoting biodiversity offset projects and generating certified biodiversity credits thanks to 3bee all these needs will be met
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the human genetic and immunological determinants of the clinical manifestations of sarscov2 infection towards personalised medicine
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the consequences of sarscov2 exposure range from a lack of infection to lethal covid19 this immense interindividual clinical variability is the key scientific and medical enigma in the field while age and certain comorbidities are known to influence disease outcome these parameters do not explain all variation in addition there are other sarscov2 phenotypes of clinical importance multisystem inflammatory syndrome in children and adults misca and longcovid an important breakthrough to unravel the pathogenesis of covid19 came from our two science papers that were recognized by nature among the top 10 discoveries of 2020 we found that about 4 of patients with critical covid19 pneumonia had inborn errors of immunity iei that impair tlr3 and irf7dependent type i interferon ifn immunity and at least 10 of the patients carried preexisting autoantibodies autoabs neutralizing type i ifns these findings pave the way for further studies of covid19 pneumonia and other sarscov2 infection phenotypes and form the basis of the present research proposal undine which follows a bed side to bench and bench to bed side approach with the following objectivies i to decipher the genetic and immunological basis of the various sarscov2 disease manifestations to identify individuals at increased risk of critical covid19 postinfectious immunological complications and vaccine failure iii to develop readytouse diagnostic tests for largescale detection of autoabs to type i ifns and propose novel preventive and therapeutic approaches based on the pathogenesis of sarscov2 infection for translation into personalised medicine to achieve these goals our project will coordinate a european multidisciplinary and translational research effort relying on a strong and synergistic combination of assets including unique cohorts from 11 eu countries and stateofthe art human genetic immunological and virological expertises and technologies
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automated synthesis of certifiable control software for autonomous vehicles
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autonomous driving is a dominant technological theme of the 21st century with vehicles from various car manufacturers equipped with different levels of autonomy however the implementation of safe and reliable control software remains a critical challenge for car manufacturers before fully autonomous vehicles become a reality the current lack of reliability in autonomous vehicle software is mainly attributed to the absence of formal correctness design requirements are not expressed in a formal language leading to ambiguity and false implementations furthermore human factors from engineers to developers increase the likelihood of errors and testing scenarios are limited leaving many edge cases untested immature control software leading to accidents undermines public trust in autonomous vehicles and impedes further development we propose leveraging our ongoing erc project autocps research to create robust reliable and formally correct automotive control software certicar proposes a software development framework that automates control software generation and guarantees its robustness and reliability a reliable advanced collision avoidance system acas is a fundamental requirement for future autonomous vehicles significantly reducing the number of accidents injuries and fatalities certicars poc project aims to provide a correctbydesign acas with guaranteed correctness reducing testing time by several orders of magnitude for car companies and represents an initial step toward a complete software stack for a certifiable autonomous car
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deep learning based interpretable pediatric brain tumors segmentation and classification
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the dlipbratsc project aims to address the significant impact of pediatric brain tumors pbts as the leading cause of cancer death in children and adolescents artificial intelligence ai technologies are increasingly being explored to assist doctors in detecting and diagnosing through clinical decision support systems cdss however they face the challenges in successfully segmenting pbts due to the scarcity of available medical image datasets additionally the lack of transparency in blackbox ai models has raised concerns among doctors hindering the adoption of ai in cdss to tackle these challenges the project will develop a stateoftheart interpretable aibased framework to classify pbts including tumor segmentation dlipbratsc will identify the location of pbts classify of pbt types and enable quantitative analysis of subregion of pbt parameters helping clinicians in diagnosis treatment planning monitoring disease progression and predicting patient outcomes the project will start with collecting and preparing sufficiently large balanced pbt medical images from secondment institution with the assistance of medical experts an online test platform will be implemented for clinicians to use the model gathering feedback for further validation and improvements the nonacademic placement will provide realworld clinical validation of the models efficacy the project findings will be shared in conferences or journals targeting both neuroscience and informatics dlipbratsc can help healthcare providers make more informed decisions about diagnosis and treatment planning of pbts and contribute to early detection and intervention these can lead to better patient outcomes improved overall healthcare delivery and public health outcomes and reduced healthcare costs aligning with the eus objectives of providing ensuring the safety and wellbeing of its citizens and one of the irish national research priorities areas health and wellbeing
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understanding gene environment interaction in alcoholrelated hepatocellular carcinoma
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alcoholrelated hepatocellular carcinoma aldhcc is in europe the leading cause of liver cancer 2nd most common cause of cancerrelated death worldwide affecting both men and women aldhcc has a median 5year survival rate of 15 yet the prognosis is driven by the tumour stage with curative options providing a 5year survival exceeding 70 for earlystage hcc 20 of cases therefore interventions aiming to improve prevention and early detection are key aldhcc results from the interplay between environmental determinants and genetic variations a comprehensive characterisation of environmental factors eg diet lifestyle linked to aldhcc is still lacking we recently performed the 1st genomewide association study of aldhcc and identified predisposing genetic variations however their role on alcoholrelated liver carcinogenesis needs clarification and the genetic architecture of aldhcc remains mostly unknown genial brings together partners with unique expertise in clinical hepatology singlecell and spatial multiomics artificial intelligence ai and communication and dissemination capacities our aim is to 1 portray genetic and environmental determinants promoting aldhcc 2 evaluate how they interact at cellular level in human samples and preclinical models to get novel insights into liver carcinogenesis and identify chemopreventive targets and 3 assess how these determinants modulate the aldhcc risk in prospective cohorts of patients included in hcc surveillance programs environmental factors will be comprehensively characterised in an ongoing clinical trial designed to evaluate alternative methods for earlystage hcc detection finally ai models reaching the minimal viable product stage by the end of genial will be used to integrate genetic and nongenetic information including digital imaging to develop novel costeffective strategies towards prevention and earlystage detection of aldhcc in atrisk individualsthis action is part of the cancer mission cluster of projects on understanding
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sustainable photoelectrochemical valorization of flue gases
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in the road to sustainability the treatment of postcombustion emissions is still far from being technoeconomically viable on one end the low concentration of co2 in these streams precludes the use of current carbon capture cc technologies on the other end even if cc were successfully implemented there are not plausible final uses maybe except geological longterm storage our ambitious proposal aims to investigate the viability of a technology able to tackle these challenges at once our superval technology will develop scientific solutions from lowcost noncritical raw materials and processes with the added value of removingvalorizing the nox contaminants from flue gaswe propose to design and realize an autonomous solarpowered installation able to capture harmful emissions from flue gas and valorize them as commodities for the chemical industry using water as sacrificial source of electrons and protons the co2 will be transformed into an organic energyrich molecule formate the nox will be also captured and transformed in combination with n2 into ammonia using the hydrogen obtained in the co2 coelectrolysis processes this integrated effort will offer the comprehensive capture and valorization of carbon and nitrogen components in postcombustion emissions thus limiting pollutants and resulting in addedvalue chemicals the corresponding technoeconomic analysis and life cycle assessment studies will help to shape the components and performance of superval as a useful technological advancement in the search for zero net emissions
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the glue of society a social ontology of social cohesion
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social cohesion is a key concept in how we think about the social world and yet we have a very poor conceptual understanding of what social cohesion is how it relates to other social phenomena and which role it plays in maintaining social order and facilitating cooperation to date this challenge has not been taken up by social ontology contemporary social ontology primarily focuses on understanding the nature of collective cooperation in which people coalesce around a joint purpose in such a way that we can attribute attitudes and actions to them as a collective rather than as an aggregation of individuals but social cohesion is not only a function of collective cooperation but also the extent to which a social system enables mutually sustaining cooperation among agents with separate goals call this converging cooperationit seems then that social cohesion is a key concept in how we think about the social world that lies beyond the scope of social ontology in its current form responding to this impasse the aim of the glue project is to secure philosophical clarification of the concept of social cohesion and to account for its role in constituting and maintaining the social worldthe primary research questions are1 what is social cohesion and which distinct social phenomenon might it refer to2 what are the semantically explanatory relations between a social cohesion and b the concepts often used in social ontology and the social sciences to account for collective cooperation3 how can a clearer account of social cohesion be used to foster social stabilitycombining descriptive explanatory and critical approaches to social ontology glue a enriches our typology of social dynamics b expands the scope of social ontology beyond collective cooperation c introduces concepts that can help identify and mitigate forms of social destabilisation and d develops a new and integrative research method for social ontology
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particle composition in relativistic jets
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relativistic jets launched by supermassive black holes are the most extreme and energetic persistent phenomena in the universe they are capable of accelerating particles to energies inaccessible by particle accelerators on earth and deposit enormous amount of energy in their surroundings during their lifetime they are believed to have a significant impact on galaxy evolution via feedback mechanisms yet despite decades of studies one of the most fundamental properties the composition of these jets is still unknown the jets can consist of either electronpositron pairs electronproton plasma where also protons are present and accelerated or an admixture of the two the composition affects the power of the jet and the presence or lack of hadrons is a crucial ingredient in modelling the multiwavelength and multimessenger emission of these jets if the jets are hadronic they are likely the origin of the highest energy cosmic rayscircular polarization is the only direct way to determine the particle composition of jets and we have designed a project that will overcome limitations of previous programs to finally resolve the particle composition of relativistic jets previously this has only been attempted on individual objects at low radio frequencies or using singlefrequency data lacking the required discriminating power particles will deliver the first multifrequencyradio highcadence observations of relativistic jets in total intensity linear and circular polarization for a sample of objects in parallel we will conduct very long baseline interferometry observations to connect our light curves with the spatially resolved structures in the jets this unprecedented dataset will be combined with radiative transfer simulations crucial for modelling the origin of circular polarization these advances will enable us to answer one of the most central questions related to relativistic jets what is their particle composition
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contribution of the epsteinbarr virus and the tumour microenvironment to antiapoptotic mechanisms in dlbcl
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diffuse large bcell lymphoma dlbcl accounts for over onethird of lymphomas and is fatal in up to 40 of cases particularly poor survival is associated with dlbcl subtypes that overexpress the oncogene myc and contain the cancercausing epsteinbarr virus ebv these tumours frequently resist apoptosis with a poorer response to chemotherapy recent evidence has strongly implicated a role for the tumour microenvironment tme in cancer progression however the relationship between ebv myc and the tme in dlbcl remains poorly understoodcomand aims to elucidate the synergistic relationship between ebv myc and the tme to explore how these oncogenic drivers converge to protect dlbcl tumours from apoptosis this will be achieved using a new generation of ebv and ebv dlbcl models to derive novel insights into the biology of ebv dlbcl this will be coupled with stateoftheart intravital imaging of tumour progression in humanised mice and highly multiplexed spatially resolved imaging of the tme in ebv patient tumours this will allow the study in unprecedented detail of the impact of viral and cellular oncogenic drivers on the tme and apoptosis in dlbclthis research directly contributes to cancer and infectious diseaserelated eu and un goals and will support the areas of open science gender equality and the green charterthe fellow will spend 2 years at the walter and elisa hall institute of medical research australia expanding her skills in in vitro disease mimetics and acquiring a skillset in apoptotic pathways and intravital imaging she will return to the university of limerick ireland and receive training in highdimensional imaging and data analyticsthe fellow will be immersed within a multidisciplinary team with expertise in lymphomagenesis virology apoptosis and the tme they will support her in meeting the researchtraining objectives and preparing for an independent career in the field of ebvassociated lymphomagenesis
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twinning innovation hub for microbial platforms in plastic upcycling
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plastics have become indispensable in various industries today but their widespread use has resulted in a severe environmental crisisplastic waste accumulation traditional methods of plastic waste management are insufficient and recycling faces quality and degradation challenges enter upcycling a process gaining prominence in converting plastic waste into valuable chemicals and materials in an ecofriendly mannertwinn4microup presents an innovative approach to plastic waste upcycling employing green biomechanochemical technologies to recover plastic monomers modern molecular techniques will be utilized to create microbial cell factories capable of producing bioactive compounds from these plasticderived feedstocks revolutionizing industries related to biocolorants biotherapeutics bionutraceuticals biosurfactants and biomaterialstwinn4microup is on a visionary mission to create the microup hub an advanced research and innovation hub in synthetic microbial biotechnology in our pursuit of maximal impact we aim to establish strategic partnerships strengthen ntuas capabilities enhance scientific excellence and promote entrepreneurship and innovation our overarching goal is to establish ntua at the core of the microup hub leaving a lasting legacy by advancing scientific knowledge environmental protection public awareness economic development and global collaboration together we are steering toward a sustainable and responsible future
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revitalising languages and safeguarding cultural diversity
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languages have always played an important role when groups of people were living side by side speakers might be suppressed or take up a new language but as much as a language says a lot about individual identity it also carries a large reference to the culture and history of the group in which it is spoken and the cultural background it is tightly interwoven with emotions and traditions which are worth keeping up as they stand for personal rootsrise up interconnects all relevant knowledge actors including citizens civil society and end users it collects and analyses background information it identifies good practices and develops new methods with the help and support of people being concerned and interested in the topic thus rise up aims at the empowerment of these endangered language communities fostering their selfconfidence and overcoming past trauma in the understanding of the rise up consortium these endangered language communities include learners new speakers people who have not had the chance to learn their heritage languages supporters and other interested parties as well as actual speakersrise up explores and deals with a context reasons and policies for endangered languages within europe b collecting and creating a set of tools to support local communities c interconnecting relevant groups of stakeholders and d involving and attracting especially young people and other stakeholders eg by using digital tools
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practices of unfreedom in northern france 8881121
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the proposed project aims to fundamentally reframe the social history of the thousands of unfree persons living in france during the central middle ages it will do so by applying methods and frameworks from the growing field of the history of slavery and dependence moving away from redundant narratives of a transformation from antique slavery to medieval serfdom it will draw upon a wide range of documentary sources from four ecclesiastical provinces in northern france tours rouen sens and reims to create a database of the practices and interactions between unfree dependents and their lords in the period ad 888 to ad 1121 once completed this database will allow for a detailed analysis of the social and economic roles played by practices of unfreedom in medieval society the three key research themes of the project the imposition of unfreedom the agency of the unfree the historical record of unfreedom will be explored in two peerreviewed journal articles one in french and the other in english the researcher dr niall silleabhin will conduct the project over 24 months at the centre dtudes suprieures de civilisation mdievale cescm in poitiers a vibrant interdisciplinary centre for medieval studies the research will be conducted under the supervision of prof martin aurell an internationally renowned expert on the power of medieval social lites the projects training element involving mentoring digital training and participation in academic discussions and outreach will allow the researcher to develop transferable skills in archival research digital humanities techniques research project management and multilingual scholarly communication these skills in addition to the strengthening of existing collaborative european networks will significantly enhance the researchers career prospects allowing him to become an international research leader in medieval social history
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toeplitz and related operators in large bergman spaces
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we consider operator theory in bergman spaces consisting of analytic functions on complex domains the aim is to extend known central results of standard bergman spaces to the case of large spaces which are naturally defined by using rapidly decaying nondoubling weights the need of weighted estimates is as apparent as anywhere in harmonic analysis and applications in the context of bergman spaces the case of nondoubling weights is still partially open due to the fact that such weights are not so naturally related with the hyperbolic metric of the underlying domain in this context we plan to consider questions of boundedness of the bergman projection in weighted lpnorms in relation to the boundedness of toeplitz and also little hankel operatorsin the case of standard weighted bergman spaces there is a wellknown connection of the theory to the deformation quantizationanother topic of recent interest is formed by the so called localized operator classes we aim to extend these studies to the case oflarge bergman spacesthe methodology comes from the earlier joint works of the researcher and a number of well known experts in the area on the topicof pointwise estimates of the bergman kernel among others and from the techniques of the supervisor and wlusky as well as fockspacemethods which are naturally related to nondoubling measures
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food safety for africa
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the food safety for africa fs4africa proposal is designed to address food safety challenges in africa focus is given to addressing food safety issues associated with weak channels for value chain organisation traceability authentication of safe food food safety challenges addressed include mycotoxin contamination in multiple food crops including food and feed pesticide residues in grains and vegetables microbial contamination particularly escherichia coli contamination and food adulteration of foods the aim of the proposed proposal is to improve african food safety systems with particular attention to the informal sector through local market transformation enhancing food security and regional trade while reducing negative impacts on the environment biodiversity health and society to by utilizing expertise skills networks and tools available within the consortium comprising partners based in africa and europe we aim to address food safety challenges through policy development implementation of existing policies implementation of strategies uplift the informal sector using a combination of tools approaches to transform the informal sector to a mezzanine status utilizing digital tools communication of strategies utilization of sound scientific social and technological approaches tools in physical sciences social science and humanities including in behavioral science one health preservation of biodiversity is given attention in the proposal through implementation of interdisciplinary approaches that given consideration to human animal environmental and plant health by employing strategies that meet the needs of the present without compromising the ability of future generations to meet their own needs the proposed project will leverage on activities of other projects in previous and current eu projects and involve collaboration with the joint research center especially as ec knowledge center for global food and nutrition security
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research action network for reducing reactive nitrogen losses from agricultural ecosystems
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globally 5070 of the n fertilizer applied to cropping systems is lost as nitrate and noxides raising agricultural production costs and contributing to pollution and climate change these losses are directly linked to the nitrification process catalysed by soil nitrifying microbes the mitigation of reactive nitrogen nr loss via nitrification inhibitors nis is a promising solution for increasing n use efficiency nue in agriculture actionr aims to unravel the scientific excellence and innovation potential of a widening country greece through a european network of excellence on establishing novel tools and pathways for optimized nue reducing the continued acceleration of the n cycle and decreasing the environmental footprint of nr as a centre for greek agricultural production thessaly is suited to serve as a model for research on microbial n transformations for optimizing nue in agroecosystems but local capacity is not fully explored yet twinning of uth with two internationally leading partners in ecogenomics univie and microbial ecology ecl of the soil n cycle will i further develop research excellence of uth ii improve its networking efficiency and interdisciplinarity and iii have broad societal and environmental impact towards more efficient n management in agricultural settings these objectives will be achieved through the implementation of a welldesigned plan of training networking and disseminationcommunication activities including staff exchanges onsite training summer schools and symposia working groups on protocol unification integrated phd programs and outreach events directed towards potential stakeholders and local communities the expected impacts include an increase in scientific output and capacity building of uth the integration of sustainable nfertilization strategies at eu level in compliance with sdg eg sdg13 and 15 and the stimulation of public awareness on agrienvironmental issues
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transformative pediatric brain cancer imaging using integrated biophysicsai molecular mri
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despite vast drug development efforts brain tumors remain the leading cause of pediatric cancer deaths noninvasive monitoring of treatment response is crucial to reveal the mechanisms behind tumordrug interactions and optimize patient care however standard magnetic resonance imaging mri methods involve injecting metals have severe difficulties in differentiating treatment response from tumor progression are qualitative and mandate prolonged anesthesia due to the lengthy acquisition i propose to develop a transformative molecular mri technology based on the chemical exchange saturation transfer cest contrast mechanism that will enable specific quantitative rapid contrastmaterial free treatment monitoring of pediatric brain cancer recently i revealed that a combination of mathematical cest models and ai can generate quantitative biomarker maps of ph and protein concentration changes across the brain two known hallmarks of cancer inspired by these results i now propose to adopt a previously unconsidered perspective and to represent the underlying physics of cest mri as a computational graph enabling an automatic aibased optimization of molecular imaging i hypothesize that the combination of biophysical models with a new ai framework and their synergetic integration throughout the entire imaging pipeline will provide accurate noninvasive treatment monitoring first i will establish a method for automated optimization of mri protocols for early determination of the tumor response to mainstream chemotherapy next i will shorten the 3d scan time by an order of magnitude and quantify the response to next generation immunotherapy third i will translate the method to clinical scanners and validate it in a human pediatric pilot study this research will yield a fundamental understanding of the molecular mechanisms underlying treatment response and establish an innovative precision medicine methodology that will transform pediatric cancer imaging
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cocreating actions to improve rationality in the health system
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despite widespread recognition of social economic or environmental health determinants health action remains heavily dominated by individuallevel solutions eg medication patient counselling vaccination this proposal aims to stimulate changes in health system functioning by demonstrating how the cocreation of actions to address psychological wellbeing cardiovascular health and antimicrobial resistance from within the community can alleviate the burden on primary care services reduce medicalisation and increase health equitythe scientific approach uses mixed methods and incorporates theory from multiple disciplines we will appraise how the current system addresses psychological wellbeing cardiovascular health and rational use of antibiotics using a population survey a survey of patients collecting their medication at community pharmacies aggregate health service indicators on medication consumption and primary care consultations and qualitative methods exploring stakeholders perceptions we will undertake communitybased participatory research to engage citizen scientists in the cocreation of communityled actions to promote psychological wellbeing cardiovascular health and prevent antimicrobial resistance the design implementation and evaluation of the actions will apply an assetsbased approach and apply theories and frameworks from implementation science in an iterative manner over 3 years finally we will analyse the impact of the cocreated actions considering effectiveness and broader contextual issues such as initiative adoption implementation and maintenance this will use a beforeafter comparison of survey indicators an interrupted timeseries analysis of health service data and qualitative analysis the goal is to demonstrate how the integration of community action with attention to the social determinants of health can lead to a more rational approach to health care and ultimately improve health and health equity
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bandresolved imaging and nonlinear optical control of currents in topological materials
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topological materials have captured the imagination of scientists with unique electronic dispersions and surface states while their potential seems huge from advanced photodetectors to spintronic devices so far it has not come to fruition despite two decades of research in this proposal my aim is to reveal and control lightmatter interactions electron populations and currents in topological bands by combining two fields of research topological materials and nonlinear optical coherent controlnonlinear quantum coherent control was a major leap in ultrafast science enabling optical control of chemical reactions and electronic processes in atoms and molecules on femtosecond time scales in solidstate systems despite some pioneering experiments coherent control has not been widely used this is partially due to the complex band structures and partially because transport research has tended to be more easily applicable to the solidstate realm topological materials however are especially promising candidates for coherent control because a it has proven hard to access properties related to the topology in 3d materials via transport and b topological bands are associated with unique optical selection rules and as recently revealed fascinating nonlinear optical phenomenain this project i will develop nonlinear coherent control of photocurrents in topological materials thus building a bridge between nonlinear control to transport measurements of topological bands i will use timeresolved arpes a powerful tool providing bandimaging out of equilibrium to enable imaging of the photocurrents within the topological bandsphototopocurrent will establish a new research direction which will provide a deep understanding of the unique optical couplings and nonlinear optical responses of topological electronic bands allow us to develop sophisticated optical schemes for tailored control and finally implement them in transport devices
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the emerging role of target of rapamycin in regulating the shadeinduced pathogen susceptibility in plants
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in close proximity plants can sense each others presence via a decrease in the red to farred light ratio low rfr in the nearby surroundings low rfr perception by phytochrome photoreceptors triggers strong and rapid elongation growth allowing plants to grow taller than their neighbors and reach better lit areas this process known as shade avoidance is mostly orchestrated by the growth hormone auxin however although low rfr promotes elongation growth it compromises plant defense against pathogens by dampening defense hormone signaling a phenomenon referred to as shadeinduced susceptibility furthermore i recently found that plants exposed to low rfr conditions accumulate glucose which accelerates pathogen development in plants tissue yet the involvement of primary metabolism in regulating the shadeinduced susceptibility remains to be explored in eukaryotes the target of rapamycin tor kinase is a master growth regulator integrating the cell energy and carbohydrate status to regulate growth and defense responses in plants tor activity is promoted by auxin and glucose both strongly induced by low rfr interestingly i also found tor gene expression to be induced by low rfr in a recent rnaseq study in this project i will study if and how low rfr regulates tor signaling to promote growth at the expense of defence i will use genetic and chemical approaches to i identify the spatiotemporal dynamics of tor gene expression and tor protein activity in response to shade in the model plant arabidopsis thaliana ii identify the dependency of shadeinduced auxin levels and sugar accumulation on tor dynamics and iii characterize potential links between tor signaling and defense hormone signaling the gained insights will be instrumental for understanding how plants use shade signals to balance growth and defense responses and will help to engineer new pathogenresilient crop varieties which can be grown optimally at high densities
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economic policies for the global bifurcation doctoral network
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due to human activities at stake is the habitability of the planet and our capacity to invent effective inclusive and democratic trajectories that preserve or restore the viability of the planet to overcome the limits of mainstream economic paradigms epogdn aims to develop a community of economists able to work with other disciplines and a range of sectors and stakeholders to address these ecological challenges epogdn investigates the trajectories leading towards a strong sustainability ie scenarios considering social economic and ecological objectives as not substitutable to this end epogdn introduces the concept of global bifurcation gb defined as a series of processes which are systemic and multidimensional in nature to face the complexity of the gb epogdn proposes an original approach based on a a sociotechnical perspective and critical questioning of the role of innovation and technologies b a socioeconomic perspective involving the development of macroeconomic scenarios c a socioecological perspective to enable consideration of how social organisations and citizens can contribute to the gb d the interaction between these subfield to develop a systemic approachepogdn involves academic governmental and intergovernmental institutions local authorities ngos financial and nonfinancial corporations phds are jointly supervised by an economist and a supervisor from another field disciplines involved include economics sociology geography political sciences engineering life and earth sciences they benefit from international mobility in relation to their research at the institution of the joint supervisor and a secondment at a nonacademic partner the training includes collective activities and activities tailored to individual needs which cover interdisciplinary approaches and methods promote discussions with stakeholders from different fields and sectors and enhance transferable skills and professional development
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beyond maximalism the role of domestic political institutions in the making and reception of excessive state claims
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maximalist claims over territory and other goods abound in global politics yet we lack a basic understanding of what makes a claim maximalist what factors drive maximalist claims and how they can be countered while russian claims concerning ukraines foreign policy and territorial integrity as well as chinese claims to the entirety of the south china sea strike most citizens analysts and policymakers as maximalist the conceptual distinctions between such claims and other more ordinary claims have not been made in the international relations or law scholarships lacking a conceptual basis we also do not know much about how to study the causes and consequences of maximalist claims this project is a valuable first step in the direction of analytically rigorous and policyrelevant studies on excessive claims and ways to counter them the proposed research defines maximalist claims as those that ostensibly go beyond the relevant rules of international law and claims made by other states it aims to collect original data on all maximalist territorial and maritime claims in the postworld war ii period bridging comparative politics and international security scholarship it will formulate and test hypotheses linking domestic political institutions with the making and reception of maximalist claims moreover it will seek to adduce experimental evidence to the mechanisms underlying perceptions of maximalism and formulation of appropriate responses throughout the main objective of the project will be to understand how regime type influences interactions over maximalist claims involving both states and international organizations this contribution is particularly timely given the rise of authoritarian regimes and authoritarian tendencies even in otherwise established democracies supported by robust communication and dissemination activities these studies will advance the scholarship on multiple fronts and provide valuable input for policymaking processes
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quantum secure networks partnership
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the quantum secure networks partnership qsnp project aims at creating a sustainable european ecosystem in quantum cryptography and communication a majority of its partners which include worldleading academic groups research and technology organizations rtos quantum component and system spinoffs cybersecurity providers integrators and telecommunication operators were members of the european quantum flagship projects civiq uniqorn and qrange qsnp thus gathers the knowhow and expertise from all technology development phases ranging from innovative designs to development of prototypes for field trials qsnp is structured around three main science and technology st pillars the first two pillars next generation protocols and integration focus on frontier research and innovation led mostly by academic partners and rtos the third st pillar use cases and applications aims at expanding the industrial and economic impact of qsn technologies and is mostly driven by companies in order to achieve the specific objectives within each pillar and ensure that knowhow transfer and synergy between them are coherent and effective qsnp has established st activities corresponding to the three main layers of the technology value chain components and systems networks and cryptography and security this framework will allow achieving the ultimate objective of developing quantum communication technology for critical european infrastructures such as euroqci as well as for the private information and communication technology ict sectors qsnp will contribute to the european sovereignty in quantum technology for cybersecurity additionally it will generate significant economic benefits to the whole society including training new generations of scientists and engineers as well as creating hightech jobs in the rapidly growing quantum industry
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pats eliminating pesticides
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pats provides a fully automatic insect control solution which combines automated monitoring and ai solutions with high control methods such as batlike hunt drones and ultrasonic predatorprey confusionour vision is to revolutionize agriculture by combining biology with technology we offer an ecosystem of innovative solutions designed to enable organic farming and significantly reduce insecticide usage by integrating biological control with our technological methods we aim to cut insecticides by 75 and achieve a 10 reduction by 2030our control methods effectively tackle hardtomanage pests that previously necessitated insecticides the collateral damage from these chemicals disrupts biological control not just for these pests but also for others our automated monitoring provides precise data on flying pests natural predators and pollinators this granular data empowers farmers to optimize biological control improving its efficiency and making it a sustainable choice
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an integrated typologybased approach to guide the future development of european historic buildings towards a clean energy transition
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the process of future proofing the built heritage faces the paradox of needing standardised approaches but having a heterogeneous stock with very specific needs futurhist will rely on the identification and characterisation of local uniform building typologies as a lowest common denominator to develop tailored intervention approaches that can be standardised and replicated in all buildings of that category with minor modifications the standardised approach will then serve as a basis for the adaptation to other typologies in the same context climate regulations etc or even similar typologies in terms of materials configuration etc in different contextsalthough considerable progress has been done in recent years in terms of development of materials and solutions compatible with conservation of historic buildings several challenges remain still open futurhist will develop both passive and active solutions with a focus on an efficient use of energy and resources improved wellbeing enhanced durability revalorization of existing materials and techniques integration of renewable energy systems and smart solutions for decarbonising heating cooling and ventilation mentioned here just as examples be a claybiocharinsulation selfhealing lime plaster and hybrid originalvacuum glazingdemonstration is at the core of the project the solutions developed as well as the approach will be implemented and tested in four cases in spain poland sweden and the uk the diversity and geographical distribution of the demo cases will ensure the validation under different climates construction typologies and socioeconomic environments the demo case owners as members of the consortium will facilitate a rapid uptake of the results to be implemented in their large portfolios immediately after the completion of the project moreover the involvement of heritage authorities and partnership with icomos and intbau will ensure trust and widespread replication
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subcutaneous delivery of theranostic cellbased therapies
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this poc project seeks to develop a simpletoimplement selfassembled and injectable hydrogel material for the controlled codelivery of our similicar nk cells and stimulatory cytokines to improves treatment of both solid and liquid tumors similar to biologics delivery where monoclonal antibodies mabs are commonly administered by iv infusion due to regulatory criteria favoring such route which had limited confounding factors the iv administration remains responsible for some over costs and clinical challenges including the need for dedicated infusion facilities aseptic preparation of required infusion batches extended infusion times potential difficulties and risks with iv catheter the subcutaneous sc administration is deemed to overcome many of these challenges and might appear as an attractive alternative to the iv administration in addition the sc route used for mab administration was received with an overwhelming preference according to patients despite limited and reversible local adverse events induced by the rhuph20 alternative solutions are being evaluated through clinical trials such as the direct sc injection of mabs without recombinant human hyaluronidase or using novel enzymes but none are currently being clinicallydeveloped for cellular therapies moreover those alternative sc methods induced large pharmacokinetic heterogeneity between patients confirming the need to develop novel alternative approaches to accelerate the development of sc mabs formulation hence in parallel to the biological approach chemistrybased approaches such as hydrogels have been proposed however to date none of them successfully managed to be translated to the clinic this can be explained by the absence of full biodegradability after injection orand potential poor biocompatibility inducing inflammatory responses here we sought to develop a novel formulation of functionalizedchitosans for controlled release of modified nk cells
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accelerate positive clean energy districts
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ascend accelerate positive clean energy districts seeks to accelerate the implementation of positive clean energy districts pced for cities transition toward climate neutrality and social justice across europe ascend will deliver two inclusive affordable pceds in lyon and munich
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hierarchical porous peek via combined physical foaming and additive manufacturing bringing circularity to advanced engineering materials
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a number of engineering applications require lightweight structural materials providing a good combination of stiffness toughness and strength including transportation buildings and energy storage and conversion fibre reinforced polymers frp in the form of monolithic and sandwich structures are nowadays mostly used in lightweight aerospace applications however frps present an intrinsic sustainability hotspot given the difficulty on their recycling high performance thermoplastic cellular solids hptc are excellent candidates for those applications requiring a compromise between mechanical and functional properties ensuring at the same time recyclability by using thermoplastic polymers the main intrinsic advantage of cellular solids is the ability to tailor their properties by tuning the microstructure cell size wallthickness and distribution however conventional foaming techniques such batch foaming extrusion foaming or foam injection moulding do not allow for precise control of the obtained cellular morphology production of cell size gradient or the manufacturing of hierarchical macromicroporous structureshippeek aims at developing a processing strategy towards the manufacturing of porous materials of small controlled and graded cell size and shape through additive manufacturing am focusing on polyetheretherketone peek peek is a highperformance engineering thermoplastic with high strength to weight ratio reported as an excellent candidate for metal replacement in a variety of applications including space aerospace automotive medical and dental functionally graded porous peek will be accomplished by the combination of environmentally friendly physical foaming with inert gases with the production of threedimensional scaffolds through resource efficient am which will allow the production of controlled multiscale hierarchical structures on the micro and meso scales together with optimized topology at the macro scale
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the effect of media multitasking on online prosocial and antisocial behavior
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digital devices and portable media platforms have become integral parts of peoples lives causing an increase in online activities and an inclination for simultaneous consumption of different media known as media multitasking aka mmt extant research suggested that mmt causes cognitive strain and emotions and influences an individuals information processing abilities likely influencing ones online social behavior osb pro and antisocial project multiple examines how multiple dimensions task hierarchy emotional content of the task and time pressure of mmt activities may influence emerging adults engagement in osb it aims to determine how changes in task hierarchy and the emotional content of the tasks affect individuals engagement in osb whether the inclusion of time pressure in the interaction of task hierarchy and the emotional content influences individuals engagement in osb other goals are to identify the underlying mechanisms ie mediators eg frustration cognitive load and moderators eg tendency to express online impulsivity to understand the said relationship the methodology integrates eye movement tracking controlled computerbased laboratory experiments and questionnaires the irtis dept at the mu leads in the media and cyberrelated studies and will help the researcher with the teams stateoftheart infrastructure the project will create a crossdiscipline theoretical framework information and communication cognition and media and help generate guidelines for improving the work environment in organizations where mmt is prevalent
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evolution in security and privacy for 6g networks
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ensure6g project will develop robust solutions to provide resilient 6g telecommunication infrastructure in the presence of both cyber and physical attacks in 6g networks the rationale for the ensure6g project is well justified due to the need for advanced and intelligent security and privacyenhancing mechanisms deployed in practice within current mobile networks and the necessity of novel efficient mechanisms for future networks ensure6g will have a strong impact on the careers of all participating staff involved it will equip them with cuttingedge technical and practical knowledge in the security and privacy of 6g technologies it will create an opportunity to build a strong professional network and bond with industry partners beyond the projects completion date the ensure6g will aim to ensure that the eu is at the forefront of security and privacy requirements of 6g networks and that new security measures are designed to mitigate the risks associated with new 6g end user devices and users
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enhancing cancer vaccine science for new therapy pathways
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the main objective of the project enhancing cancer vaccine science for new therapy pathways canvas is to significantly raise the scientific profile networking and research management competencies at the international centre for cancer vaccine science iccvs at the university of gdask ug poland to achieve improved research excellence in cancer vaccine science the project aims to contribute to reduction of the disparities in ri in europe by networking activities with outstanding leading european research partners university of rome tor vergata unitov italy and alternative energies and atomic energy commission cea france the partnership includes also a biotech startup real research poland to foster intersectoral knowledge transfer for innovative translational research approaches a strong focus on upgrade of grant writing and research management skills will improve longterm competitiveness in obtaining funding in addition a joint pilot study is planned in the project we expect that it will provide the foundation for a novel patient tailored therapy of nonsmall cell lung cancer thus apart from the scientific impact in the long term innovations generated with the support of the canvas partnership have a translational potential to contribute to improving therapy for cancer patients which give the project a pivotal economic and societal impact
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performant and efficient planar protonconducting electrolysis reactor
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the pepper project introduces a groundbreaking advancement in hydrogen production technology aimed at meeting the soaring global demand for green hydrogen at the heart of pepper lies the development of a cuttingedge planar proton conducting ceramic electrolysis cell pccel reactor operating optimally between 400c and 600c peppers pccel technology aligns seamlessly with industrial waste heat sources maximizing resource utilization by harnessing two robust planar cell technologies and optimizing material interfaces and manufacturing processes pepper aims to slash electrical energy consumption by up to 20 compared to existing lowtemperature electrolysis methods led by the deutsches zentrum fr luft und raumfahrt ev dlr pepper boasts a consortium includes key european research and industrial partners this collaborative effort ensures a holistic approach to research and innovation emphasizing realworld applicability peppers objectives encompass the fabrication of cells up 100cm in size the validation of pccels under various conditions the integration into specialized short stacks tailored for pccel technology and the demonstration of longterm operational stability and safety at temperatures 600c through comparative studies with solid oxide electrolysis soel pepper aims to establish benchmarks for performance and sustainability guided by comprehensive life cycle assessments lca setting a pathway towards commercializationby elevating technological readiness from trl 2 to trl 4 pepper will set the stage for a future where highly efficient and environmentally sustainable hydrogen production can significantly contribute to europes energy security and decarbonization goals
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pioneering methods to unravel lactation insufficiency
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breastfeeding is important for infant and maternal health however 1015 of breastfeeding women fail to produce enough milk while 4050 give up early because of perceived insufficiency as a result only a minority meet the who recommendation to exclusively breastfeed during the first six months to address this public health challenge two key questions need to be solved what do nursing infants actually drink and how is this milk transfer regulated by mammary physiology my vision is to pioneer new quantitative methods that allow to solve these fundamental questions building on my expertise in biophotonic innovations for neonatal care i propose to develop noninvasive optical tools to quantify milk transfer in situ wp1 and map the causes of lactation insufficiency from the largely unexplored perspective of mammary physiology wp2 in wp1 the scientific challenge is to develop methods for inline monitoring of both the milk volume consumed and its varying composition during a breastfeed i propose two novel optical methods based on light scattering by milk fat globules building upon laser doppler flowmetry volumetric flow rate and angular resolved light scattering spectroscopy composition the technological challenge is to integrate both methods into a safe compact sensor prototype engineered into a nipple shieldin wp2 i will translate the technology of diffuse optical spectroscopic imaging dosi to lactation science here the scientific challenge is to quantify mammary physiological parameters in realtime using dosi and my sensor from wp1 during live breastfeeds in both wps i will use stateoftheart medical ultrasound for validationby engineering dedicated tools for lactation research this project will enable a leap forward in the diagnosis treatment and prevention of both actual and perceived lactation insufficiency in turn this will lead to better breastfeeding support and improved individual and public health outcomes
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expanding integrated assessment modelling comprehensive and comprehensible science for sustainable cocreated climate action
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neither the first round of nationally determined contributions ndcs nor currently implemented climate policies are on track to meeting the paris agreements objectives parties are expected to increase their ambition and produce new ndcs covering the post2030 period the design of a multidimensional set of policy measures that comprise countries climate policy agendas is supported by equally diverse integrated assessment modelling iam activities notwithstanding the recent progress in the iam literature and scenario space the modelling world has fallen short of its promise to include nonscientists in its process to account for individual choices and lifestyle changes that are indirectly narrated as assumptions not interacting with the vividly modelled technologyeconomyenvironmentpolicy flows and to place climate action as a crosscutting theme in the sustainability spectrumiam compact will support the assessment of global climate goals progress and feasibility space as well as the design of the next round of ndcs and policy planning beyond 2030 for major emitters and nonhighincome countries we will use a diverse ensemble of models tools and insights from social and political sciences and operations research and will integrate bodies of knowledge to cocreate the research process and enhance transparency robustness and policy relevance we will explore the role of structural changes in major emitting sectors and of political behaviour and social aspects in mitigation quantify factors promoting or hindering climate neutrality and account for extreme scenarios to deliver a range of global and national pathways that are environmentally effective economically viable politically feasible and socially desirable in doing so we will fully account for covid19 impacts and recovery strategies and align climate action with broader sustainability goals while developing technical capacity and promoting ownership in nonhighincome countries
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uncovering the regulators of cellular plasticity by direct reprogramming
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cellular reprogramming has revolutionized stem cell biology by allowing the generation of stem cells progenitors or somatic cell identities with small combinations of transcription factors tfs currently the limited understanding of how these different degrees of plasticity are established and maintained keeps on hold the application of reprogrammed cells in the clinic with the replastic project i propose to uncover novel regulators that define degrees of plasticity and control cell identity with an interdisciplinary approach merging the fields of gene editing stem cells and immunology i will develop an innovative platform to evaluate the impact of gene knockout across the process of cell reprogramming in human cells comparing multiple cell conversion scenarios pluripotency multipotency hematopoietic stem cells and unipotency dendritic cells for this i will carry out a crisprcas9 knockout screening coupled with nextgeneration sequencing using customdesigned sgrna libraries targeting tfs chromatin regulators and rna modifiers after sequencing i will determine the molecular targets that are relevant by comparing the three reprogramming systems genes involved in cell conversion will be defined as regulators of plasticity and top hits will be validated to study their molecular mechanism and role certainly replastic will open new research avenues on the basic principles of cellular plasticity and provide groundbreaking technologies that may contribute to immunotherapy regeneration and cancer i will pursue this project as an incoming researcher supervised by dr filipe pereira lund university sweden during my stay i will acquire handson expertise in cuttingedge techniques direct reprogramming hematopoieticimmune cells gene editing deep sequencing i will also gain experience in mentorship and writing skills and expand my network by attending national and international meetings to present my work and foster new collaborations
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skills predicting understanding and locating shortages in europe
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the study will address significant gaps in the understanding of skills deficiencies in europe ie the extent causes and implications of skills shortages and skills gaps skills shortages refer to where employers face difficulties recruiting people from the external labour market because applicants lack the skills qualifications or experience sought skills gaps refer to the extent to which organisations workforces lack the skills required to meet their business goals there is a tendency to think that skills shortages and skills gaps will disappear over the medium to long term so they do not require policy interventions the evidence suggests otherwise shortages and gaps do not clear quickly enough certainly from a policymaking perspective with negative consequences for individual workers companies and in aggregate the economy as a whole this has the potential to damage organisational performance and productivity it is thus important to measure skills shortages and gaps locate where they arise or are anticipated to arise with respect to jobs sectors and countries affected and analyse their causes and means of mitigation the study will provide a conceptual review of skills shortages and gaps and devise a means of measuring their incidence and the extent to which they are likely to arise in the future as a consequence of key changes in the economy notably digitalisation the study will provide a methodology for identifying the extent causes and implications of skills deficiencies in europe a series of indicators will be devised including a skills shortage index which can be incorporated in a software tool for use by those responsible for labour market skills intelligence at national and paneuropean level the tool will be roadtested by working with those responsible for producing labour market skills intelligence at national level to develop something that provides a valuable addition to that already produced
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formation of planetary building blocks throughout time and space
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the major objective of the planetoids project is to profoundly advance our understanding of planet formation numerous discoveries of exoplanets in the last years proved that planet formation is a rule rather than an exception at the same time we made unprecedented progress in observations of the birthplaces of planets the disks surrounding young stars where dust growth up to pebblesizes is detected despite the significant progress the planet formation process remains a conundrum as its intermediate stages are essentially unobservable this project aims at constructing innovative numerical models of the early stages of planet formation when the dust grows to pebbles and becomes gravitationally bound in building blocks of planets called planetesimals despite the critical role of this phase in the planet formation process global models addressing planetesimal formation are scarce with planetoids i propose to go beyond the stateoftheart by combining the most advanced models of circumstellar disk formation and structure dust evolution planetesimal formation and planetesimal growth in one comprehensive framework the key aspects included in planetoids are 1 investigating how dust grows and circulates in winddriven circumstellar disks 2 understanding where when and how many planetesimals can emerge and how this result depends on the properties and environment of the host star 3 exploring the pathways of fast planet formation required to explain the observations of young circumstellar disks with these developments it will become possible to selfconsistently simulate the decisive early stages of planet formation for the first time the awaited results are essential for explaining the origin of the solar system and the diversity of exoplanets
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advancing knowledge of north atlantic land ice linking observations and models
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icelink will bridge the knowledge gap between climate models iceflow models satellite observations and insitu observations to accelerate the understanding of how glaciers and ice sheets in the north atlantic respond to climate change and their impacts on climate and ecosystems observations in the past decades have alerted for the rapid changes in land ice in this region record temperatures melting ice and increased fresh water flux may destabilise the atmosphere and ocean circulation with severe consequences for regional weather system sea level rise and affecting europe and beyond an improved understanding of trends and variability of ice evolution is important and icelink will address this challenge by integrating earth observation data insitu observations and ice flow and climate models into an improved understanding of the processes that control the evolution of glaciers through improved understanding of snow surface mass balance and the ice dynamical response to meltwater runoff icelink will provide new knowledge of the response of icelandic glaciers and the greenland ice sheet to global warming and the impacts on climate and ecosystems icelink will engage closely with local communities to codevelop and disseminate new knowledge needed to support adaptation strategies mitigate risks and enhance their resilience a novel approach in icelink is to investigate the effect of increasing surface melting on ice evolution of the greenland ice sheet by using icelandic glaciers as a dataobservation laboratory for understanding the response in a warmer world with more melt the improved models and new insights will feed into the world climate research programmes cryosphere project ipcc ipbes assist development of copernicus and support the destination earth initiative icelink will produce results that are in high demand in order to plan and adapt for the future
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bioarcheology of the late mesolithic the last huntergatherers of europe
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climate and sociocultural changes are major ongoing concerns in our modern societies their impacts on past populations are also central to understand the evolution of the human species its resilience and its capacity to adapt to new environments 8200 years ago the mesolithic populations huntergatherers from portugal faced a climatic event that profoundly changed their environment in a similar way to what is expected to happen in the next decades in addition to these challenges they were also confronted with the arrival of migrating neolithic populations introducing farming plant and animal domestication and sedentism gradually leading to the disappearance of the huntergatherer nomadic way of lifemuge project aims to unveil the life story of the last huntergatherers from the tagus valley muge village in portugal and to understand whether the environmental and sociocultural changes during the late mesolithic ca 82007100 cal bp impacted the composition and health of these past populations discovered 150 years ago and representing the largest european anthropological collection for the mesolithic more than 250 individuals humans from muge are still poorly studied from a biological perspective because of the state of preservation of the skeletons cuttingedge imaging techniques will allow us to correct the taphonomic alterations and go into great detail in the analysis of skeletal remains providing crucial information about the biological profile of the individuals ageatdeath sex etc the structure of the populations and their health statuswith more than 1000 years of occupation muge furnishes an ideal skeletal sample for exploring changes in health status through time and between sexes adults and nonadults but also between sites and understand the impact of each change on these populations this project is the first to combine both palaeodemographic palaeopathological and palaeoimaging approaches to the muge populations
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ncps network for the green transition in climate energy and mobility
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the overall aim of greenet is to improve the professionalisation and skills of the cluster 5 cl5 national contact points ncps across europe simplifying applicants access to horizon europe he calls and raising the average quality of submitted proposals starting from the assumption that the ncp role is crucial in order to raise the participation in he in terms of both quality and quantity the greenet overall concept is that the cl5 ncp community requires knowledge skills competences and a proven comprehensive suite of tools to convey a message in a multicultural and multidisciplinary environment such as cl5 and to effectively support its broad based constituency therefore the project is based on three pillars i ncps capacity building and competence development ii development of targeted and high quality services events and tools for cl5 applicants and stakeholders iii cl5 community building and general mainstreaming of cl5 ncps in horizon europe
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unpacking confined lives generating a global research agenda on the intersection of urban marginality displacement and incarceration
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confined will develop and validate an innovative comparative and global research agenda of confined lives confinement is a ubiquitous and unequally distributed human condition while confinement sometimes can be protective for some groups not least the displaced on dangerous roads the marginalized in urban slums and the detained in prisons it can be a damaging experience linked to violence and inequality with an empirical point of departure in different contexts across the global north and south known to produce a variety of confined lives confined explores 1 how certain peoples lives are rendered confineable 2 how confineable groups and networks navigate discursive actual and potential practices of confinement and 3 how and to what extent the concept of confined lives can transform our understanding of the practices and experiences of confinement across global divides in ways that drive theoretical innovation and help build new agendas for social justice through three interdependent and sequentially organized work packages confined proposes to explore confined lives contextually and ethnographically across the global north and south wp1 to compare what confines people how they make sense of their confined lives and how they navigate confinement wp2 and to conceptually develop and validate the approach through engagement with academics and experts locally and globally wp3 confined will carry out comparative ethnographic field work to follow precariously situated translocal family network across four contexts as a privileged lens to understanding confined lives at the intersection of dangerous journeys urban slums and prisons and camps denmark and lebanon south africa and malawi thailand and myanmar and the uk and sierra leone this will allow confined to reframe the empirical field of confined lives and to generate a new conceptual language to understand one of the most important drivers of inequality worldwide
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methods for stroke monitoring and diagnosing based on bcg
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clinical monitoring of the heart health of stroke patients is usually done by electrocardiogram ecg recording a noninvasive method that requires electrodes in contact with the patients skin to obtain the signal however since specialists are required to place the electrodes its use is restrictive contactless alternatives for study of heart conditions in less restrictive way have been investigated for decadesthis project aims to develop novel noninvasive methods for detecting cardiac and noncardiac disease in stroke patients using the ballistocardiogram bcg signal allowing for patient monitoring without transfer to clinical settings the objective of the project is to answer important questions in current research in biomedical engineering such as whether the resolution of a bcg is sufficient for the detection of cardiac conditions and whether it can become the preferred method for monitoring heart health from hometo achieve this objective the project proposes the development of a portable prototype for the acquisition of bcg signals as well as the development of novel algorithms that allow for the detection and classification of cardiac arrhythmias and episodes of sleep apnea from these signals the project will be based on three different stages design and implementation of the prototype obtaining new diagnostic support algorithms based on ballistocardiogram signals and the connection strategy at the prototype to deliver the information to the specialist doctorsthis is a multidisciplinary project that combines expertise in bioengineering health sciences electronics and telecommunications this proposal also aims to transfer knowledge to the host institution and provide training for the candidate in advanced techniques the results have the potential to significantly improve the capacity of home health monitoring and the application of ehealth knowledge this project is aligned with the eu strategy for the protection of human health
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determining the mechanisms behind goblet cell dysfunction
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goblet cells are specialized epithelial cells that secrete mucus and antimicrobial proteins which together form the gut mucus barrier the mucus barrier protects the host from bacterial invasion and subsequent activation of an inflammatory response while also providing food for the microbiome dysfunction of goblet cells and high penetrability of the mucus barrier are hallmarks of inflammatory bowel diseases ibd while the reasons for goblet cell dysfunction are unclear it is thought that inflammation host genetics specifically mutations in autophagy genes and environmental factors can affect their function yet despite their importance the basic biology of goblet cells is not understood as they are part of a heterogeneous tissue i developed a new mouse model that allows isolation of ribosomes specifically from goblet cells in vivo thus revealing the translational response of goblet cells to various conditions in preliminary studies we found that altering the autophagy process in vivo led to modification of the colonic mucus barrier alteration of the microbiome and resistance to colitis we also found that antibiotic treatment an environmental factor which increases the risk for ibd altered the mucus barrier and instigates gut inflammation in mice our goal is to mechanistically determine how inflammation autophagy and antibiotics affect goblet cell function during health and ibd we will 1 define goblet cell function during ibd development in vivo and test if goblet cells fail to regain proper function during remission leading to relapse we will also 2 use a novel mouse model of augmented autophagy to determine the role of autophagy in preserving goblet cell function during ibd lastly 3 we will use germfree mice to reveal the microbiomedependent and independent effects of antibiotics on goblet cell function and ibd our study will provide new understanding of goblet cell biology and may lead to new therapeutics which target goblet cells
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largescale and wideband brain dynamics mediating memory consolidation in the freely moving rat
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dementia is a major healthcare challenge worldwide due to its high incidence and its strong impact on the life quality of patients and on society as a whole development of treatments for the mitigation of memory impairment in patients with dementia has proven very challenging partly due to our limited understanding of the underlying mechanisms of memory consolidation memory consolidation is mediated by communication between largescale networks in the brain particularly the hippocampal formation and neocortical circuits coordinated by synchronous oscillatory dynamics as shown in both humans and animal models during the resting state in humans this coordination is associated with complex restingstate network rsn dynamics that are reflected in spatiotemporal patterns of infraslow 05hz brain activity however the link between rsns dynamics and wellunderstood neuronal dynamics underlying memory consolidation in animal models remains a major knowledge gap due to technical limitations wideband ephys has a unique potential to close this gap by mapping extracellular potentials with high spatiotemporal resolution in a wide frequency band enabling inference of rsn dynamics across brainwide networks in freely moving rats using customized graphenebased neural probes in combination with neuropixel 20 probes fiberphotometry and optogenetics i aim to investigate the mechanisms underlying memory consolidation with an unprecedented level of detail extending the current knowledge on the functional role of rsns and local slow oscillations in the rat could lead to the development of novel treatments for dementia which will be explored in collaboration with the private sector during this project the interdisciplinary approach presented in this proposal will complement my expertise in neurotechnology with more advanced skills in fundamental neuroscience enhancing my career prospects in the field of translational neuroscience
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enzymatic cascade biotransformations in digitally manufactured continuousflow bioreactors
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within industrial biotechnology applied biocatalysis is poised to transform drug discovery and development by pharmaceutical industry enzymes as catalysts allow for synthetic chemists to generate molecular complexity avoiding costly and timeconsuming protection and deprotection steps however the high cost associated to their use especially if a cofactor is required the low substrate tolerance and productivity and the difficulties for scaleup strongly limit the industrial uptake of these processes the combination of enzyme immobilisation and continuous flow cf offers an opportunity to overcome these limitations enzymatic performance and recyclability can be dramatically improved by immobilisation and generic problems such as low productivity and substrate inhibition effect can be solved using cf during the last years enzymes have been most commonly immobilised in packed bed reactors however the very low flow rates required to achieve full conversion decrease the mixing and make the system look closer to a batch reaction with its generic problems here we aim to address these limitations through the design and manufacture of 3d printed 3dp reactors that combine optimised mixing at low flow rates with tailored surface modification techniques with ionic liquids ils for stable biocatalyst preparation and higher number of active sites 3dp facilitates the generation of complex geometries in a variety of materials based on ils tailored to optimise enzyme stability the aim of this proposal is to integrate chemical engineering 3dp continuous flow reactors and biocatalysis stable and recyclable immobilised enzymes to develop more efficient biotransformations in flow easy and effective immobilisation of enzymes and significantly promote sustainable development of ib it will have a direct impact in the eu from an environmental economic and social perspective lowering drug prices facilitating distributed production and reducing waste
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elucidating the role of microbial metabolites in stabilising and protecting the leaf microbiome
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the oomycete pathogen albugo laibachii plays an important role in structuring the phyllosphere microbiome of arabidopsis thaliana plantassociated microbial communities are known to provide protection against pathogens at least in part through the production of specialised metabolites that suppress the activity of pathogenderived proteases thanks to the advances in nextgeneration sequencing and nontargeted mass spectrometry we have gained new insights into the community and metabolic dynamics of the plant microbiota nevertheless we are just at the beginning of fully capturing the sheer number and complexity of the community members and the countless still unknown metabolites they produce the molecular mechanisms underlying microbemicrobe and plantmicrobe interactions remain thereby mainly elusive so far only a few metabolites have been identified as plantprotecting agents but the full protective potential of a microbiome through the synergistic action of multiple microbial compounds remains largely hidden to shed light on the bioactive potential of the exometabolome of the plant microbiome as a whole i will apply a multimodal functional metabolomics strategy that provides information on the potential protease inhibitory activity of all the compounds secreted by a predefined synthetic microbial community our focus will be on the stabilisation of the microbial community composition mediated by protease inhibition and the related plantbeneficial activities through synergistic interactions with other defence strategies connecting those activities to individual metabolites will allow us to better understand the beneficial effects of the community as a whole and how dysbiosis may contribute to pathogenesis it will also allow for the rational design of nextgeneration microbiome derived biocontrol agents which are urgently needed for a more sustainable agriculture
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circular construction finance
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the circofin project brings together 4 cities and regions to transition to a circular economy in the construction and buildings sector munich copenhagen scotland and lisbon will prepare investmentready circular construction hubs cch and showcase how they transform local and regional markets for secondary building components and materials cch cover physical material banks and digital infrastructure to provide the resource basis for the eu taxonomy requirements for construction to date cch have not successfully scaledup across europe the project will demonstrate that cchs can become bankable projects at scale and provide lucrative investment opportunities for financiers the showcases develop sound technical business and financial plans of more than 80 m total investment volumecircofin streamlines a common project development assistance pda methodology for cch used and validated by the showcases the methodology results in a cch toolbox which consists of customizable components for all project development stages from prefeasibility to due diligence and bankability appraisal it covers all elements of cch physical design digital infrastructure logistics business models operation models and financial models the results will be published as a cch cookbook with concrete facts and figures ready for widespread replication by other cities and regions replication and rollout aim to trigger uptake in 30 other cities and regions from the ccri circular cities declaration and the mission cities of the 100 climateneutral and smart cities mission investors and eu financial initiatives will gain expertise in advising cch projects via robust technical and operational insights and learn how to review associated risks to make better investment decisions on circular economy projects standardization will on cen and iso as well as policy recommendations improve regulation to enable business and investment cases for cch market uptake in europe
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integrated assessment and advanced characterisation of neuronanotoxicity
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the incidental accidental or intentional release of manufactured nanomaterials into the environment and its exposure to humans is inevitable due to the exponential growth in invention production and use of them it can have a huge impact in our health specially in the most sensible and exposed human body organs such us lungs stomach and brain icare aim to to develop a resilient and adaptive set of advanced imaging technologies to quantify physicalchemistry properties for anmc in complex matrices the main objective will focus on a integrated model system to characterize and predict the impact of nanomaterials on brain health to prevent the toxicity nanomaterials the project makes accessible for industry a set of techniques and methodologies to evaluate changes in morphology chemical composition and reactivity of nanomaterials when exposed to complex homogenous matrices mimicking environmental and biological exposure with a particular emphasis on highresolution imaging methodologiesto achieve this goal the project the project brings together in the consortium 11 partners from different backgrounds such as rtos smes industries and universities from different eu and noneu countries and coming from different fields like nanotech toxicology advanced materials advanced imaging during the 48 months long of the project the consortium will work on the development of different activities to achieve the following results 1new imaging methods achieving new high resolution methodologies and new super resolution imaging techniques 2development of toxicology testing protocols and addressing current gaps in nanotoxicology 3development of tools and methods bringing the gap in vitro and in vivo testing 4efficiency of materials and product development 5delivery of reliable data and improved data reporting and finally development of harmonised standardised test methods that can be used in regulatory frameworks
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convection and transfers in a textured partiallymolten planet from the magma ocean stage to presentday solidstate convection
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how and when plate tectonics pt developed on earth and why the earth is currently the only rocky planet of the solar system with pt are two of the main enigmas of earth and planetary sciences the evolution of a planet is conditioned by heat transfer in its most viscous envelope the mantle this heat transfer is mostly due to convection and strongly depends on the convective patterns which in turn depends critically on mantle rheology however the link between rock rheology at small time and lengthscales and mantle effective rheology at the longlarge scales of mantle convection is still missing i propose that it resides in the mesoscale structure of the mantle and lithosphere that are acquired through convective motions and partial melting hence deciphering the evolution of the earth or any other planet requires describing and understanding the interplay between texture ie material multiscale organization rheology twophase flow and convection our team recently showed that aqueous nanoparticle colloids fluids commonly used by soft matter physicists can reproduce planetary phenomena such as onesided subduction and the twophase flow dynamics of midocean ridges building on this softplanet will combine convection in these soft materials with stateoftheart visualization techniques to relate surface morphology including faults wrinkle ridges and volcanism lithospheric structure and internal flow patterns and characterize the development of texture and rheology from the nanoscale to the macroscale of convection softplanet will map the different regimes of convection that can develop and will derive a physical understanding of each this new physical framework together with geomorphology observations will be used to decipher the current state of venus and the divergent evolution of venus mars and the earth
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