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twinning for new graphenebased composites in electromagnetic interference shielding
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intensive growth of both the telecommunication and electronic industry in recent years is occurring with the spreading of electronic device usage in everyday life the pollution caused by electromagnetic waves ews is ubiquitous ews are predominantly emitted from cell phones wifi microwave ovens etc electromagnetic interference emi demonstrates a strong negative impact on electrical devices and affects human health causing leukemia and brain tumors and the danger of emi is underlined for those with implanted active medical devices thus textile fabric that can absorb ews is in high demand in resolving such a lifethreatening matter another arising problem with ews is their effect on the working performance of electronic devices leading to untrusted signals and noise to prevent degradation by unwanted currents and voltages instrument obstruction false results and to reduce measuring time materials able to neutralize emi effects are highly needed the grinshield project will bring innovation in the field of shielding materials by exploring new nanomaterials as a protective barrierthe goal of this project is twofold to increase significantly the scientific excellence of the consortium by addressing a scientific issue with potential economicindustrial impact producing efficient shielding material based on nanotechnology materials for emi protectionto improve the administrative skills of the coordinator institution from the widening country staff through collaboration with members of the consortium from fra ger and slo offices by working with topclass partners researchers from the widening country will improve scientific skills work with cuttingedge instruments and gain frontier education enhance project writing skills and improve publication records while the administration will become a competitive dynamic and efficient instrument for preparation of international projects as well as their implementation
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molecular design and application of spliceswitching antibodyoligonucleotide conjugate for hypertrophic cardiomyopathyrelated mybpc3 splice modulation
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familial hypertrophic cardiomyopathy hcm is the most common inherited heart disease and is predominately caused by mutations in genes that encode proteins associated with cardiac sarcomeres the functional unit critical for basic contractile heart function nearly twothirds of individuals with hcm experience mild to no symptoms whereas the remaining onethird experience dyspnea chest pain or arrythmias that can progress into heart failure causing sudden cardiac death particularly in young competitive athletes current strategies to treat hcm include invasive procedures such as septal or left ventricular reduction therapies or cardiac implantation such methods are not curative but rather aimed to treat symptoms and not the pathophysiological cause of the disease thus highlighting the importance of new molecular therapies that can prevent hcm one potential method to correct hcm mutations is through the use of antisense oligonucleotides asos short polymeric nucleic acid biomolecules that can correct aberrant rna splicing a fundamental biological process for gene expression by binding to premrna splice sites and block recognition by the spliceosome however delivery of asos to cardiac cell models including cardiomyocytes differentiated from human induced pluripotent stem cells ipsccms remains to be one of the biggest challenges in aso efficacy herein this project proposes to design and test the effects of chemicallymodified spliceswitching antisense oligonucleotides conjugated to an antibody an antibodyoligonucleotide conjugate aoc using a unique traceless linker strategy that has the potential to not only treat splicing defects in hcm but also provide proofofconcept of improved cell delivery of asos aocs will be tested in ipsccms bearing cryptic splice mutations in mybpc3 myosin binding protein c a gene whose mutations are commonly associated with hcm
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assessing philosophical authors and texts from herculaneum and elsewhere on early stoicism insights into ancient logic physics and ethics towards a new von arnim
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alongside epicurus school stoicism is the most important current of thought in hellenistic philosophy the first phase of this school extends from zeno of citium 334333262261 bce to chrysippus followers viz up to the end of the 2nd century bce apart from some fragments transmitted by the medieval manuscript tradition and by the herculaneum papyri only indirect witnesses on the early stoics remain today the huge corpus of this material was collected mostly in hans von arnims stoicorum veterum fragmenta 190305 despite some partial attempts to correct and integrate this collection von arnims pioneering work is still the reference point in studies on early stoicism the present project aims to remake this work entirely through an innovative interdisciplinary methodology incorporating classical philology the history of ancient philosophy doxography papyrology and epigraphy new technologies for deciphering ancient manuscripts and will be divided into the following steps 1 a new critical edition of most of the fragments and testimonia at issue 2 a wider selection of the sources and a revision of some manuscripts 3 a new methodology for reading and reconstructing the papyrological sources 4 an innovative historicophilosophical methodology for commenting on and interpreting the extant sources 5 the creation of a website along with a digital database publication of partial and comprehensive outcomes for the project the editions will be divided into four parts focused on zeno of citium the disciples of zeno including the heterodox stoics chrysippus and the disciples of chrysippus respectively each volume will be accompanied by commentaries also devoted to stoic figures sometimes neglected in scholarship eg diogenes of babylon this project aims to revolutionize our knowledge of this fundamental phase of hellenistic philosophy by throwing new light on the history of ancient physics logic and ethics
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towards early cancer detection and tumor classification using epigenomic biomarkers in blood
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early cancer detection could increase curative treatment and longterm survival dying cells release small dna fragments wrapped around a core of histone proteins into the bloodstream socalled circulating cellfree nucleosomes cfnucleosomes they carry dna sequence information and histone modifications stable in blood reflecting promising epigenomic disease biomarkers but the low proportion of cfnucleosomes originating from cancerous cells versus the large background of nucleosomes arising from dying blood cells poses significant challenges for early cancer detection using circulating cfnucleosomes in epicblood i will tackle these challenges and propose two complementary strategies to increase the number of cancersignature cfnucleosomes for cancer detection and tumor classification in the first strategy i will employ my previously developed synthetic histone modification readers to profile abundant histone modifications on cfnucleosomes allowing me to seize up to 35 percent of the human genome noninvasively i will prove this technologys concept by detecting earlier stages of pancreatic cancer and simultaneously classifying molecular tumor subtypes furthermore i hypothesize that tumorigenesis gives rise to cancerspecific genomic sites decorated with combinatorial histone marks socalled bivalent regions found explicitly in cancer and not in healthy adult cell types in the second strategy i will employ a computational pipeline to map cancerspecific bivalent sites across multiple cancer genomes i will use my wellestablished combinatorial histone mark readers to test their diagnostic potential as cancerspecific biomarkers in blood plasma from healthy donors and cancer patients my genomics expertise and proven technology provide an excellent basis for accomplishing the planned goals epicblood will be a major step towards developing precise and rich liquid biopsy assays for multiple clinical applications in cancer management
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econometric machine learning for better heterogeneity representation
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modeling behavioral patterns of commuters and their decisionmaking process is crucial to develop sustainable and effective transport policies predict and forecast the travel mode choices of a certain population with respect to changes in some attributes or components of the transportation system and determine the different sources of heterogeneity in tastes and preferences econml is about developing hybrid frameworks that combine several machine learning techniques with econometric discrete choice models to better account for different aspects of unobserved heterogeneity within a population such as systematic and random taste variations in addition to market segmentation the proposed models would abide by mcfaddens vision of an appropriate econometric choice model in order to maintain the behavioral interpretability while improving the prediction and forecasting capabilities moreover this project will focus on estimating the proposed models using bayesian variational inference vi techniques and on providing solutions to overcome the corresponding limitations of such methods in addition a comparison of traditional estimation techniques such as maximum simulated likelihood estimation msle and expectationmaximization em with bayesian variational inference techniques will be conducted with the aim of providing recommendations on when each estimation method should be used the ultimate goal is to apply the proposed framework to realworld case studies eg shared mobility biking behavior in copenhagen adoption of electric vehicles etc and provide the authorities and operators with forecasts and recommendations for new policies that might mitigate the negative impacts of the transportation system
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compositional higherorder reasoning about distributed systems
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software systems are critical for the infrastructure of modern society and software errors and security breaches pose enormous costs and risks the traditional method of testing software systems is famously inadequate for guaranteeing the absence of errors and security breaches since not all execution paths are covered by testing this is espcially true for concurrent and distributed systems where there are simply too many execution paths to test and it has motivated research in formal methods for program verification that can offer mathematical proofs that all system behaviors meet some desirable property to formally analyze and reason about software systems it is important to consider models at many different levels of abstraction since many real software errors and security breaches stem from subtle problems in implementations of software systems we focus on detailed socalled semantic models of program execution while there has been much research on abstract models for reasoning about distributed systems there has been very little work on compositional verification of implementations of distributed systems compositional verification enables specification and verification of individual software modules and their composition and is key to achieving scalable methods that apply to large programs but the devel opment of logics and methods for compositional reasoning is hard for concurrent nondistributed programs there has been tremendous progress in the last decade on program logics for compositional verification in particular through the development of socalled higher order concurrent separation logics leveraging this progress chords will research and develop new theories program logics and methods for mathematically rigorous compositional reasoning about implementations of distributed systems and thus lay the foundation for tools that will help programmers make more correct and secure distributed systems
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longread sequencing to resolve the missing heritability in patients suspected of pten hamartoma tumour syndrome
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individuals with a genetic tumour risk syndrome are at high risk to develop cancer one of these syndromes is pten hamartoma tumour syndrome phts phts is associated with pathogenic variants pvs in the pten gene unfortunately in the majority of patients suspected of phts no pv in pten is identified these patients are considered phtslike the low diagnosis rate in this group of patients suggests the possibility of pvs in regions of pten that are not covered in routine diagnostics or suggests that pvs in other genes in the pi3kaktmtor pathway result in phtslike disease in order to identify the missing heritability in phts i aim to develop a longread sequencing lrs approach for phtslike patients which will go beyond the currently stateoftheart shortread sequencing approaches i will o1 develop a ptentargeted lrs assay and o2 perform this assay on a highly selective cohort of phtslike families n94 i then will o3 perform whole genome lrs on 25 families that were not solved by targeted lrs to identify novel genedisease associations at last i will o4 validate these new associations in a wider cohortvia this work i will improve the diagnostic yield for phts by identifying novel genetic mechanisms and genes underlying disease in phtslike patients the unique interdisciplinary structure of the department of human genetics at radboudumc will allow to rapidly implement genetic testing for the newly identified genetic causes for phts identification of the precise underlying cause of phts will enable cascade genetic testing of atrisk family members to determine their status for the causal variant and thus risk of disease to them and any future offspring furthermore this approach will allow the implementation of preventive care strategies for the family members at risk overall my proposal will facilitate a personalized care approach for phtslike patients and their families for improved clinical outcomes and reduced disease morbidity
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mental illness substance use and cardiovascular disease unravelling causal relationships
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serious mental illness depression bipolar and psychotic disorder is among the leading causes of disability worldwide disproportionately affecting people of noneuropean ancestry on top of the burden posed by its symptoms mental illness is also associated with comorbid health problems the two most important comorbidities of mental illness given their driving role in decreasing quality and duration of life are substance misuse and cardiovascular disease whether these comorbidities arise due to causal relationships is surprisingly unclear the causal direction is also uncertain does mental illness lead to comorbidities and or do comorbidities increase the risk of more severe mental illness through several prestigious fellowships i have established myself as an expert in epidemiological and genetic causal inference methods in this ambitious project i will bring together innovative approaches to unravel the relationships of mental illness with substance misuse and cardiovascular disease my aims are to 1 assess bidirectional relationships between mental illness and its comorbidities by conducting longitudinal analyses in multiancestry prospective cohort studies 2 distinguish bidirectional relationships from shared genetic liability by jointly modelling the complete genetic architecture of mental illness and its comorbidities genomic structural equation modelling 3 establish causality by using only highly significant genetic variants as instruments for one variable and testing causal effects on another mendelian randomization 4 fully unravel the nature of relationships between mental illness and its comorbidities by triangulating evidence from aims 1 to 3 and 5 assess how informing medical doctors about the outcomes of aim 4 influences their clinical decisions in a randomized online experiment this interdisciplinary project sets the stage for more effective prevention and treatment of mental illness across ancestry groups
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circular fuel supply for air transport via negative emission htl conversion
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achieving climate neutrality in europe requires large volumes of truly sustainable fuels to provide longterm solutions for transport sectors where direct electrification is not viable circulair addresses this challenge with an integrated biofuel pathway that produces costeffective aviation fuels and generates negative emissions key innovations of circulair involve a close thermal coupling of hydrothermal liquefaction htl conversion based on abundant and available agricultural residues and lignocellulosic crops with exothermic wet oxidation of htl process water in this way autothermal operation can be achieved carbon is fully utilized and the process water disposal problem of htl is solved in addition circulair develops innovative approaches to upgrade htl biocrudes to jet fuel and accelerates the approval of htl fuels for civil aviation the biomass resource utilization is maximized by developing valorisation schemes for all relevant side streams along the process chain in particular acetic acid will be extracted from residual process waters and methanol will be synthesized from effluent gas streams and renewable hydrogen importantly circulair will close a knowledge gap regarding the utilization of fixed carbon in the htl solids for carbon sequestration and soil amendment ie for a negative contribution to the carbon balance the targeted overall netnegative emission will be quantified based on life cycle analysis finally techno and socioeconomic analyses will identify important benefits and tradeoffs associated with the advanced biofuel process in summary circulair will investigate and develop an innovative process for resourceefficient production of sustainable aviation biofuels alongside further marketable renewable chemicals and fuel products the utilization of biomass feedstock that is abundant in agricultural environments ensures costefficiency relevant scale and the potential to create netnegative carbon emissions
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skeletal muscles antagonize t cell exhaustion in chronic viral infections
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although skeletal muscles are not traditionally considered to be constituents of the immune system the loss of skeletal muscle mass in chronic infection is frequently associated with impaired t cell function or t cell exhaustion whether and how muscles regulate t cell exhaustion is unknown we found that skeletal muscles antagonized t cell exhaustion in mice chronically infected with lymphocytic choriomeningitis virus lcmv clone 13 spleenderived exhausted cd8 skeletal muscleinfiltrating lymphocytes smiles formed clusters in muscles where their antiviral function and proliferative potential were restored these revived cd8 smiles egressed from muscles and migrated back to lymphoid organs to sustain longterm antiviral immunity we aim to understand how skeletal muscles regulate antiviral cd8 t cell function metabolism and migration1 using metabolomics and rnasequencing approaches we identified 46 metabolites that were enriched in muscle interstitial fluid and two myokineencoding genes that were upregulated in muscle tissue respectively we plan to test whether and how these metabolites and myokines restore the antiviral functions of exhausted cd8 t cells2 we found that the cd8 t cell migration between the spleen and skeletal muscles was guided by a protein gradient of regulator of g protein signaling 16 rgs16 we plan to identify the rgs16interacting partners and the molecular mechanisms underlying rgs16 protein gradientdriven cd8 t cell migration 3 we observed that increasing muscle mass using a genetic approach resulted in both increased numbers of cd8 smiles and decreased viral titers in lcmv clone 13 infected mice we plan to explore the therapeutic potential of increasing muscle mass for enhancing protective t cell responses in chronic infectionscollectively we will study the role of muscles in recharging exhausted t cells and will evaluate the therapeutic potential of increasing muscle mass in chronic infections
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central and peripheral nervous system action of gipr in obesity and diabetes
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obesity is a major health threat but efficient pharmacotherapies are yet not available first demonstrated by us to decrease body weight and hyperglycemia in obese mice unimolecular coagonists at the receptors for glucagonlike peptide1 glp1 and the glucosedependent insulinotropic polypeptide gip efficiently corrected obesity and type2 diabetes in recent phase 3 clinical trials while glp1rgipr coagonists are safe and effective gip regulation of metabolism remains enigmatic with gipr agonists and antagonists both decreasing body weight and blood glucosemy lab recently identified the cns gip receptor as a key regulator of energy metabolism by showing that cns loss of gipr renders mice resistant to gipinduced body weight loss emphasizing the relevance of this discovery we showed that glp1rgipr coagonism loses its superior body weight lowering potency over glp1r agonism in cnsgipr ko mice my studies now finally enable assessment of how gipr antagonists and glp1rgipr coagonists regulate energy and glucose metabolism whether gipr antagonists improve metabolism through central and peripheral mechanisms which central regionsneuronscells are targeted by gipr antagonists and by glp1rgipr coagonists and the molecular mechanisms through which they control energy and glucose metabolism remain unknown in this project i will solve the conundrum of how gipr antagonists and glp1rgipr coagonists improve energy and glucose metabolism i will map regional gipr distribution aim 1 identify the central target regions of gipr antagonists and of glp1rgipr coagonists aim 2 delineate their cellular and molecular signal mechanisms aim 3 and assess functional relevance of gipr signal modification in key neuronalcellular populations and the periphery aim 4 my studies will significantly advance the knowledge on how gipr signaling regulates metabolism and will illuminate the paths for the development of future obesity drugs
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late lifeapplicable enhancement of longevity and fitness
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aging represents gradual organismal decline driven by accumulation of cellular and molecular damages including dna damage and metabolic failures at young and middle age these damages are mitigated by tailored repair systems such as autophagy and dna damage response the repairs can be triggered through adaptive stress responses induced by antiaging interventions such as dietary restriction dr and dr mimetic metformin recently we found that loss of metabolic plasticity and repair activities due to aging abrogate longevity benefits of adaptive stressors at old age specifically we found that aginglinked failures of mitochondria and lipid catabolism limit metformin benefits and confer metformin toxicity in late life and others showed comparable limitations for dr and exercise our findings demonstrate that antiaging treatments do lose efficacy in old organisms and new approaches are required to promote healthy aging in late life here we will use multiomics and functional tests in c elegans shortlived killifish and longlived mammals to a probe the origin of aginglinked adaptive failures and b find molecular and therapeutic solutions for overcoming these failures omics tests and survival screens will be used to uncover mechanisms of intrinsic resilience against late life toxicity of metformin and other adaptive stressors in nematodes additional omics data will be analyzed to probe adaptive basis of the exceptional mammalian longevity in nmr and whale followed by attempted replication of uncovered differences in shorterlived species nematodes and fish by drugs and gene changes with an outlook of triggering superior stress resilience and metabolic plasticity in late life our expertise will allow testing late life responses to diverse adaptive interventions from moderate genotoxic stress to dr mimetics and microbiome manipulation this innovative program will illuminate novel treatments for healthy longevity that are not limited by aging
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a complete biomethane set from agricultural byproducts to energy a new concept for the exploitation of agricultural residues
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nowadays the construction of digesters for biogas plants is made of steel or concrete which is highly expensive and not ecofriendly recent changes on eu directives on lowering incentives for biogas production have excluded sophisticated solutions promoting the choice of simple innovative and costefficient solutions alvus proposes a new construction philosophy for the digesters based on the ecofriendly solution of mechanically stabilized earth mse our solution provides the following advantages i realization of larger volumes at a drastically reduced cost 55 capex savings compared to traditional concrete digesters ii lower co2 emissions up to 85 reduced environmental impact and better incorporation of the plant in the agricultural landscape and iii easy and quick construction thanks to this eic project alvus will be able to develop validate and commercialize a disruptive innovation revolutionizing the entire biomethane market
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revolutionizing ai in drug discovery via innovative molecular representation paradigms
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artificial intelligence ai in the form of deep learning is driving unprecedented progress in numerous fields eg for protein structure prediction and organic reaction planning in drug discovery and chemical biology such progress is an evolution rather than a revolution several tasks still await to be solved by ai eg accurate structureactivity and activitycliff prediction and design of structurally innovative chemical matter increasingly complex deep learning approaches are leading to progressively smaller gains in model capabilities calling for a revolution in ai for drug discovery the springboard for this project is a striking observation while novel deep learning algorithms are in continuous development the input raw molecular representations they rely on eg smiles strings and molecular graphs have not considerably changed in the last four decades limiting the amount and quality of chemical information learnable by ai the potential of capturing more sophisticated chemical information better into a new molecular language is still untapped and bears promise to revolutionize molecular ai reminder will break with traditional approaches and shift the object of study from increasingly complex algorithms to novel molecular representation paradigms for ai reminder will be an agent of change in the molecular ai landscape by developing a new representation framework at the interface between method development and experimental validation reminder will disrupt the potential of ai to a navigate complex structureactivity landscapes b design innovative bioactive molecules from scratch c leverage binding pocket information for molecule discovery by transforming the chemical information captured for ai we open opportunities to develop more efficient models and solve open scientific challenges reminder will create the basis for exciting new technology in the field of deep learning for drug discovery and chemistry at large
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deciphering fibrosis reversal mechanisms in chronic blood cancer for identification of novel predictive and therapeutic strategies
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fibrosis is estimated to be involved in 45 of global mortality and currently no specific therapies for fibrosis in most organs exist one central and controversially discussed question in the field of organ fibrosis is is fibrosis truly reversible in rewindmf i will address this biologically and clinically highly relevant question in a prime example bone marrow fibrosis in a chronic blood cancer called primary myelofibrosis pmf in pmf hematopoietic stem cells become mutated and activate fibrosisdriving cells fibrosis reversal in pmf is possible through allogeneic stem cell transplant asct however the majority of patients are not eligible for this highrisk procedure alternative fibrosisreversing strategies are not available leaving this patient group without any treatment optionmy specific aims in rewindmf are 1 to gain spatiotemporal insights into fibrosis reversal and mutant clone elimination mechanisms to predict which patients will benefit from asct and to identify therapeutic targets 2 to understand how blood cancer is maintained in the bone marrow and later the spleen stroma in order to find new ways to reverse fibrosis and eradicate the cancer cells and 3 to validate fibrosis reversal mechanisms and translate them into clinically relevant therapeutic strategies what makes rewindmf unique is the holistic benchtobedside approach starting from a stem cell biological hypothesis tested by innovative murine models and stem cell approaches advanced by a broad interdisciplinary expertise with novel single cell spatial genomic and computational technologies to dissect mechanisms of fibrosis reversal and develop therapeutic approaches which go beyond pure target identification the integration of all these technologies in clinically relevant specimens with followup data and large independent validation cohorts will truly revolutionize the prognostication and personalized treatment of patients with mf
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ecofriendly extraction of flavonoids from barley waste using deep eutectic solvents for sustainable resource utilization
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brewers spent grain bsg is a significant byproduct of beer brewing accounting for 85 of the waste produced and 31 of the original malt weight therefore there is a need to explore various recycling methods for this residue and transform it into valueadded products the objectives of this proposal align with several un sustainable development goals as they address sustainable food production and sustainable consumption focusing on health and wellbeing in this study we aim to utilize the bioactive phenolic compounds present in bsg to improve the shelf life of meat products to achieve this we will use environmentally and socioeconomically innovative methods for the valorization of bsg by using deep eutectic solvents des for the first time the use of environmentally friendly solutions for the extraction of bsg flavonoids will present improvement in terms of cost safety and environmental friendliness compared to existing methods for extractraction optimization of extraction conditions temperature solventtosolid ratio extraction time ph will be carried out to improve the selectivity efficiency and purity of target compounds des a solvent will be synthesized to selectively promote the extraction of rutin proanthocyanidins and catechin extract with phenolic acids an important aspect of this work will be to evaluate the toxicity of both the des solvent and the extracted compounds to ensure their safe use a number of analytical techniques will be used to evaluate the extraction efficiency of the flavonoid compounds primarily highperformance liquid chromatography hplc in combination with mass spectrometry ms in addition various methods will be carried out to evaluate the antioxidant profiles of the extracts finally the proposed project will demonstrate the use of the extracts in red meat products pork and beef and evaluate how these extracts can positively influence the shelf life and sensory properties of such products
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urban bordering an ethnographic study of the ghetto package in denmark
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at a time when migration is increasing many eu countries still struggle with fully accepting migrants and other minorities in this context increasingly member states introduce laws and regulations that police borders and reinforce social boundaries and as a result undermine the idea of liberal democracy these practices often labelled bordering constitute attempts to control and order the unknown or undesired subjects while much literature has dealt with this it remains understudied how bordering works in and through urban planning and housing the proposed project addresses this lacuna through an interdisciplinary analysis of such a practice of urban bordering the ghetto package in denmark ie a set of laws implemented to break up migrant parallel societies and enforce social mixthe proposed project further develops existing studies dealing with bordering by linking three scientific strands of literature anthropological criminology urban studies and migration methodologically it will rely on participant observation focus groups lifehistories and semistructured interviews in two different housing areas affected by the ghetto package in denmark this way it will complement the existing analyses on the normative and discursive elements of bordering with an ethnographic account of its implementation and social and political consequences likewise focusing on an iconic liberal democracy like denmark will elicit knowledge on potential societal effects regarding citizenship and belonging in the eu academically the project will benefit from the placement at the university of copenhagen the prominent research centre the centre for global criminology and a secondment at the inspiring research environment at the amsterdam institute for social sciences research university of amsterdam
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multimaterial additive manufacturing for lightweight and thermal management
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the 26th climate change conference has highlighted the urgent need to reduce global carbon dioxide emissions to limit global warming the transport sector accounts for approx 16 of the global carbon emissions and has identified fleet electrification as the primary route to achieving climate neutrality however the main challenges are the current weight of components and the cost of new systems to ensure efficiency and longterm sustainability as a result the industry has recognised the need for transformative technologies and production methods to develop lighter more efficient and costeffective solutions to enable this transition and achieve climate neutralitywith their outstanding mechanical strength carbon fibre composites cfc have been increasingly used to replace metals in products requiring lightweight features such as aircraft or highperformance vehicles however due to the traditional manufacturing process and poor thermal conductivity the use of cfc has been limited to structural applications for example batteries electrical motors and power electronics where power losses need to be efficiently dissipated typically require separate heat exchangers resulting in heavier and less costeffective solutions that still utilize bulky designs and heavy materialsthe vision of multhem is to develop a reliable and validated additively manufactured am cfc process with enhanced thermal conductivity with different material combinations and nanotechnology this innovative approach will allow the development of components such as battery and motor housings with dual functionality comprising structural and cooling features and with a more costeffective approach than traditional methods this solution will enhance the product performance first by the weight reduction achieved by designs that only am enables and second by using cfcmetal structures with enhanced thermal conductivity strategies lighter and stronger than aluminium or steel
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improving access to services for victims of domestic violence by accelerating change in frontline responder organisations
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in combatting domestic violence progress has been made however policy implementation remains slow and domestic violence mostly remains underreported by the victims and underdetected by the frontline agencies improve project develops several tools to increase reporting and detection of domestic violence by empowering the victims to understand their rights for services and justice and by supporting police authorities civil society organizations and other frontline responder organisations to enhance their competencies to utilize innovative solutions that enable and accelerate policy implementation improve will develop conversational multilingual ai chatbot aino that provides the victims immediate advice and risk assessment as well as guidance towards the available service provisions the performance of ai chatbot will be consistently improved by machine learning using inputs from the victimsurvivors improve will support the planning and decision making of policy makers and managers to fully utilize innovative solutions in the priority areas in order to accelerate policy implementation and enhance positive operational outcomes through effective application of tools procedures and measures to combat domestic violence improve will address frontline responders training needs by designing training materials covering sector specific and crosssector contents supported by innovative teaching and learning methods improve will construct and deliver targeted awareness campaigns for the victims their social environs and community representatives as well as frontline responder practitioners managers policy makers and academic experts innovations produced by improve are based on applied research that constructs a pioneering conceptual approach that is able to address diverse identities of the victims the underserved vulnerable and marginalized individuals and multiple forms and situations of domestic violence
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neutrons electrons and xrays serving the transition towards a sustainable environment doctoral programme
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nextstep will train 36 young and enthusiastic researchers to exploit the unique and transversal capabilities of analytical research infrastructures ris in tackling the challenges associated with sustainable development and industrial competitiveness in the areas of health digital industry space climate energy and mobility and food bioeconomy natural resources agriculture and environment which are at the heart of horizon europe these skilled researchers will be able to explore materials science chemistry biology and engineering and environmental sciences with unprecedented precision in space time and sensitivity using the ri techniques they will also be trained in complementary skills in innovation entrepreneurship and leadership providing them with the fluidity to be comfortable in all research and career settings at the heart of nextstep are the complementary and sophisticated analytical xray neutron and electron microscopy techniques available at the cuttingedge european ris european synchrotron radiation facility esrf xray synchrotron institut lauelangevin ill neutron source and edream advanced electron microscopes the academic research and technology organisations rto and industrial partners for each nextstep dc topic will be selected through europewide open calls for challenging and rewarding dc projects and will be included as associated partners this will create an outstanding geographicallydiverse and inclusive study programme fostering a crossborder knowledgetriangle network far beyond that of the recruiting institutes themselves nextstep graduates will be poised to become the drivers in future efforts to exploit the exceptional capacities of analytical ris and transform science output into disruptive solutions the graduates will have influence and impact for decades to come as they progress in careers be they in academia industry stakeholder or ngo organisations
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diabetes lower extremity complications research and training network in foot ulcer and amputation prevention
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dialect aims to combat diabetic foot disease through personalised medicine by establishing an innovative international interdisciplinary and intersectoral research and training effort that will deliver the next generation of leading entrepreneurial and creative scientists to reinforce the european innovative workforce this is both timely and urgent illustrated by that the burden of diabetic foot disease is in the top10 of all medical conditions and emphasized by the fact that every 20 seconds someone in the world loses a leg because of foot disease currently we lack success in delivering the right treatment to the right person at the right time to prevent foot ulceration and amputation we will provide unique worldclass interdisciplinary and intersectoral training to a new generation of highachieving dcs in the areas of biomechanics activity behaviour and footwear related to diabetic foot disease a wellbalanced consortium of academic industry healthcare and implementation partners will deliver the carefully designed dialect training network comprising training through research structured networkwide training events intersectoral secondments and future work skills training this will result in a paradigm shift towards personalised medicine that goes beyond stateoftheart by developing new personalised risk stratifications biomechanical foot models innovative activity and adherence profiles wearable technology systems for biomechanical and activity monitoring and personalised optimised footwear intervention products dialect will provide dcs with a comprehensive skillset capable of delivering highquality scientific and industry solutions to develop into leading innovators in the european healthcare sector who are highly employable and ready to engage and lead the next european generation of scientistsentrepreneurs to expedite progress in reducing the patient societal and economic burden of diabetic foot disease
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political and community engagement trust and identity among european adolescents and emerging adults
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the project will develop and validate measures on adolescents and emerging adults social cultural and political identity their sense of belongingness in different groups their participation in physical and online communities their interest in democratic participation and their trust in democratic institutions the measures will be used to explore and understand 13 and 15year olds political and community engagement in almost all countries in europe through the survey health behaviour in schoolaged children a whocollaborative study as well as emerging adults turned 18 years of age further qualitative information on adolescents and emerging adults perspectives of what is political and community engagement to them and how to they act on or communicate their perspectives on key societal issues will be collected and analysed the project will also identify formal and informal structures for youth democratic participation in a selected number of countries a key focus here will be to explore adolescents and young adults participation in communities on social media platforms to learn where and how they communicate their political and community engagement finally the project will develop policy initiatives with adolescents and emerging adults and policy makers using the cocreate dialogue forum tool including piloting of strategies in living labs marginalized groups will be given particular emphasis in the analyses to identify need for specific focus in policy development strategies
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effective advancements towards uptake of pv integrated in buildings infrastructure
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increase aims to contribute to a wider uptake of ipv by delivering innovations at module and system level as well as for the design operation phase new encapsulants and coatings will be developed contributing to improved aesthetics reduced glare lower environmental footprint improved behavior during fire and improved antifoiling and antisoiling behavior at system level innovations focus on integrated facade and roof concepts as well as noise barriers practical guidelines will further be delivered for bespoke infrastructure integrated projects validated with a variety of complementary infrastructure integrated pv projects elaborate testing is foreseen at module and system level in line with relevant construction related and electrical standards optimal casespecific selection of ipv size and characteristics will be supported by a multiobjective optimisation software that takes into account the shape and use of the building or infrastructure its surroundings and its energy flexibility potential and steer the asset operation as well as suggest specific user behaviour to maximise the selfconsumption to increase market acceptance a strong layer of user feedback and cocreation underpins the overall rd activities and contributes to delivering 10 complementary building and infrastructure demonstrations on 9 locations in 6 european countries crosssector interactions policy exchanges investor dialogues and countryspecific business case assessments will further direct the exploitation towards large scale market uptake
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neuronal mechanisms for conscious perception
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understanding the mechanisms for consciousness is arguably one of the most intriguing questions of modern neuroscience why are some visual stimuli consciously perceived whereas others remain subliminal what is the relation between conscious perception attention and working memory recent work of my lab demonstrated that weak but simple stimuli can be reported once they elicit a minimal level of activity in the frontal cortex which is related to the storage of the stimulus in working memory for these simple stimuli the visual cortex acts as a relay station that needs to pass the information to higher cortical areas however we found that the perception of more complex visual stimuli relies on a more sustained interaction between visual cortex and associative brain regions related to scene segmentation and visual attention these recent results pave the way for a genuine understanding of mechanisms for consciousness inspiring new paradigms that assess the awareness of stimuli while varying the demands on attention and working memory the present proposal will be the first to compare the neuronal fate of simple and complex stimuli that do and do not enter consciousness across most brain regions we will measure the activity of single neurons in human patients who are implanted with electrodes as part of their treatment of drugresistant epilepsy we will also use a new method that permits the recording from numerous single neurons within an entire hemisphere of a monkey and characterize neuronal activity in most regions of the cortex and subcortex we will use perturbation methods at numerous locations throughout the brain in combination with functional imaging in monkeys to measure a functional connectome and to investigate the brain regions in which activity does or does not readily lead to a reportable experience the proposed combination of experiments will provide unprecedented insight into how sensory stimuli give rise to conscious perception
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ai and robotics for prostate biopsy
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the robiopsy project aims at evolving the robotic device for prostate cancer pc biopsy demonstrated during the ercpoc prost into a product prototype that will be ready for clinical trials the focus of the project will be twofold the engineerization of the prost prototype and the accurate analysis of the business case of prostate cancer diagnosis and its potential extension to focal therapy we will correct the shortcomings of the preclinical tests meet the strict medical certification regulations and address the health economics implications of our solution robiopsy will achieve better performance than current competitors because it solves the two main causes of pc diagnostic error uncertain target identification and inaccurate needle positioning as demonstrated in the preclinical tests a novel image fusion method will permit to significantly reduce the target uncertainty while the robotic device will zero the positioning errorthe robiopsy prototype will consist of a single cart holding the robotic needle positioner and housing all the electronic components the electronics will be divided into two subsystems interface and data processing and safety critical controls this will reduce the operational risks and will simplify the medical certification a multicentric study is ongoing to collect biopsy images to train the machine learning algorithms for prostate segmentation and lesion identification in parallel to the technical development we will analyze in depth the business case of prostate biopsy in selected european countries we will analyze the timecost reduction due to the new device and will establish the economic foundation of focal therapy to be ready for the expected evolution of pc treatments
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citizenoriented valorisation for advancement learning and uptake in europe
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the overall objective of covalue is to boost uptake and deployment of research results by adopting a covalorisation approach that strengthens the role of societal actors in knowledge valorisation citizen engagement will be embedded in knowledge valorisation by deploying capacity building peer learning actions and experimentation covalue will capitalise on and contribute to eu initiatives such as the knowledge valorisation platform through the production testing and improvement of best practices and lessons learned in two european territories alicante in spain and emilia romagna in italy in each territory quadruplehelix stakeholders from the research innovation ecosystem will be involved in the codesign and implementation of covalorisation exploiting ongoing knowledge valorisation processes such as developing innovative solutions to address the lack of raw materials and its impact on citizens welfare alicante or specific funding schemes and projects to introduce multistakeholder engagement in publicfunded research emilia romagnathe transfer of best practices and skills will be guaranteed by a comprehensive scheme of capacity building peer learning and shadowing opportunities both at local and international level the involvement of umbrella organisations such as ebn errin and universities alliances will foster a wider uptake of covalues trainings and tools thus supporting the implementation of new practices by knowledge valorisation agents beyond the project consortium incentives for researchers to engage with society and for society to engage with researchers will be codesigned with stakeholders in each territory and implemented throughthe involvement of local ri public administrations tangible changes in local covalorisation agents will be exploited to showcase improvements together with a coassessment of enabling conditions processes and impact performed together by all stakeholders involved
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realization and imaging of superconducting spinwave optics
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spin waves are collective excitations of the spins in magnetic materials they play a central role in the thermodynamics of magnets and are promising signal carriers in classical and quantum information devices spin waves offer nonreciprocal transport low damping microscale wavelengths at microwave frequencies and strong interactions that enable signal conversion as such spin waves have raised the hopes of enabling information technology with functionalities and efficiencies beyond those provided by noninteracting particles a key requirement is realizing efficient lowdamping spinwave control a potentially groundbreaking but virtually unexplored method is provided by superconductors superconductors have no electrical resistance precluding damping by eddy currents and a strong diamagnetism that enables strayfield control of the refractive index governing spinwave transport moreover superconductors are sensitive to electric currents magnetic fields temperature and light providing tunability as such superconductors provide unique opportunities for realizing lowdamping tunable spinwave optical devicesi propose to realize and locally study superconducting spinwave optics i will create spinwaveoptical devices mirrors waveguides beamsplitters and resonators by harnessing the dissipationless superconducting diamagnetism i will then demonstrate the power of superconductorcontrol by tuning the devices using electric currents magnetic fields temperature and light in addition i propose to use superconductors to engineer spinwave damping and enter new regimes of flatband and topological transport to locally study spin waves underneath superconductors i will use magnetic imaging based on spins in diamond a technique pioneered by my lab the project thus aims to engineer and understand magnetsuperconductor interaction realize tunable lowdamping spinwave devices and launch the field of superconducting spinwave optics
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empowering widening universities in eutopiahealth consortium to foster academic excellence in health
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challenges in health require integration of knowledge and communication between specialists from different healthrelated fields to develop effective solutions the eutopiahealth project a eutopiahealth consortium initiative aims to create a novel and innovative framework for the integrative academic management of healthrelated scientific areas facilitating changes in the academic landscape within the european research area through a comprehensive institutional transformation the project targets three widening countries romania slovenia portugal of the consortium that have traditionally lagged behind in healthrelated domains striving to overcome funding and publication disparities and spearheading academic excellence and innovation in these critical domains therefore the project aims to empower institutional transformation by strengthening healthrelated ri management capacity upgrading and adapting ri management strategies and policies within widening heis of the project consortium in line with the principles of the european research assessment reform a healthfocused ri network within eutopiahealth consortium will be established through connected health research communities that will receive intertransdisciplinary trainings research mobilities for earlycareer researchers and seedfunding for research collaborations all centered around healthrelated challenges by employing integrative transdisciplinary approaches and implementing flexible academic career pathways in health the project focuses on creating a health innovation ecosystem bridging the health research communities to society business partners and policymakers by mainstreaming opencitizeninclusivecollaborative science practices and translating research into tailored social innovation supported solutions eutopiahealth project through its comprehensive activities will positively impact the ri achievements research excellence international visibility funding absorption rate of the widening consortium heis and of entire eutopiahealth consortium
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twinning with isma to develop innovative calorimeters for high energy physics based upon advanced scintillation materials
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twismas overall aim is to boost the scientific excellence and innovation capacity of the institute for scintillation materials isma and its highquality twinning partners cern and institute of light and matter to develop innovative calorimeters for high energy physics hep based upon advanced scintillation materials to achieve this aim twisma will implement a research and innovation strategy over three years based upon five objectives implemented via five corresponding wpsobjective 1 conduct exploratory research on innovative calorimeters for hep based upon advanced scintillation materialsthe objective is to develop a prototype homogeneous calorimeter based upon bismuth germinatesilicate oxides plus a prototype sampling calorimeter based upon cedoped garnet fibres both calorimeters for application in hepobjective 2 transfer knowledge between experienced researchers ers of isma and twinning partnersthe objective is to organise short term staff exchanges trainings and seminars for ismas ers and the twinning partners ers to complement the preparatory research undertaken in objective 1objective 3 enhance career prospects of earlystage researchers esrs of isma and twinning partnersthe objective is to enhance the career prospects of ismas esrs and the twinning partners esrs by organising short and mediumterm exchanges training workshopsseminars summer schools and a joint phd programmeobjective 4 improve ismas management administrative capacity for european rd programmesthe objective is to improve the skills of ismas planning department in proposal preparation project management and innovation management for european rd funding programmesobjective 5 raise the research profile of isma the twinning partnersthe objective is to raise the research profile and scientific reputation of isma and the twinning partners through a comprehensive range of dissemination exploitation communication and outreach activities
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epos optimization and evolution
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the european plate observing system epos is the sole distributed paneuropean research infrastructure ri for solid earth science enabling open access to highquality multidisciplinary data products and services based on the achievements of the previous eu projects on the design implementation and preoperation of the epos ri the epos on project will support the consolidation of the infrastructure and pave the way for its further evolution the project will enable the epos ri to meet longterm sustainability conditions for operation relying on its ability to create value for the scientific and it communities and to produce new insights for contributing to societal challenges related to risk management and environmental impact reduction epos on aims to enhance the epos services portfolio and develop new institutional and scientific collaborations by fulfilling the needs of different communities and by encouraging the establishment of new epos thematic core services this will provide the necessary impulse to expand access to data and services to a wider pool of users in particular early career researchers at both the european and global scale user engagement will also increase thanks to the new generation of processing and workflow services developed during the project epos on is also devoted to shortening the gap between science and the private sector by enabling knowledge transfer and technological innovation as a result epos on will reinforce the epos capability to unite scientific communities and countries reducing fragmentation in the european research area epos on offers a timely opportunity for the optimization and evolution of the epos ri and reflects the strong commitment of its community to boosting epos impact
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the oceans role in mitigating climate change mechanistic understanding of the legacy of anthropogenic heat and carbon in the ocean under netnegative carbon dioxide emissions
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the ocean has absorbed vast amounts of anthropogenic carbon and heat canth and hanth respectively due to humans carbon dioxide co2 emissions to the atmosphere and resultant atmospheric warming we expect absorbed canth and hanth to leak back to the atmosphere under netnegative emissions and atmospheric cooling yet such leakage and its impact on earths climate evolution are poorly understood earth system models used for such research do not resolve the most energetic features of the ocean that is ocean mesoscale features that mix and transport waters across ocean regions where most of canth and hanth is stored i hypothesize that mesoscale features accelerate the transfer of canth and hanth towards leakage sites with potential implications for climate under netnegative emissionswith the project ostia i will set out to test this hypothesis to do so the project team will set up an innovative tool an earth system model rich in ocean mesoscale features and equipped with a novel joint modeling approach for canth and hanth the earth system model will be exposed to a co2 emissions scenario that is consistent with a warming target of around 15oc by the end of the century includes netnegative emissions after 2050 and extends until 2300pioneering outcomes of ostia will be i a game changer in mechanistic understanding of the legacy of canth and hanth in the ocean for the next 10 human generations and ii to inform if current earth system models are fit to represent canth and hanth legacy effects caused by the ocean mesoscale under netnegative emissions the objectives of ostia are pressing given that delay in ambitious action to cut co2 emissions leads to further accumulation of canth and hanth in the ocean and a reliance on future netnegative emissions in order to meet promised climate targets a successful implementation of ostia will be a step change in the emerging research field of the oceans response to netnegative emissions
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multimodal imaging of lung tissue based on libs maldi and histology fusion to unravel sarcoidosis causes
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sarcoidosis is an inflammatory granulomatous disorder with unknown cause highly associated with occupational exposures it has geographically variable prevalence with an elevated cost for the patients it can be detected among metalexposed workers firefighters rock glass wool or agriculture workers the most prominent example being rescuers in the world trade center in 2001 the need for accurate information about the exposures and causes of sarcoidosis is a limiting factor for clinicians therefore supplying them with relevant information will improve the patients healthcare trajectorythe aim of imatlas project imaging analysis of tissues via laser spectrometry is to develop a novel multianalytical procedure based on libs and maldimsi in combination with standard histology to identify localize and relate exogenous and endogenous agents allowing to elucidate possible external causes and biomarkers of sarcoidosis a data analysis pipeline will be created containing all the biostatistical steps graphical representation exposure and biomarker search approaches as well as the image fusion results to provide a global view with elemental and molecular information of the tissue in addition to the pathologic information provided by histology the scripts will be publicly accessible available to other researchers as well as widely adaptable to different imaging techniques and instruments furthermore the results obtained will be released as an easytoread file quicklook to present all the useful multimodal analytical information to clinicians and optimize the diagnosis and treatment of patients
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experimental investigation of co2 solubility trapping in heterogeneous 3d porous media
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atmospheric co2 contributes to 23 of the earths global warming by greenhouse effect storing co2 in deep geological formations is the main mitigation measure currently available expeco2soltrap addresses solubility trapping st a trapping mechanism of co2 in dissolved form within the resident brine of the subsurface porous medium which allows storing co2 perennially by gravity st has been studied extensively in the last 10 years but numerical studies cannot account for the pore scale heterogeneity of the flow while most experiments cannot provide a full measurement of the system evolution in particular its dissolution flux recent groundbreaking experiments by the host group and secondmend group of expeco2soltrap have shown that the growth of the instability is orders of magnitude faster than that predicted by a darcy scale numerical simulation of the experimental process due to coupling beween the gravitatitional instability and the heterogeneity of pore scale flow this effect has been hitherto ignored in the literature furthermore the impact of darcy scale heterogeneity has hardly been studied in particular not experimentally expeco2soltrap proposes to i extend the experiments developed in the host group and secondment group to allow for pore scale measurement of fluid velocities threedimensional 3d granular porous media in order to fully understand the aforementioned coupling and ii to study the impact of darcy scale eg permeabilityporosity heterogeneity of the medium experimentally in granular porous media as well as in 3dprinted porous media of controlled heterogeneity two experiments both relying on refractive index matching of the flowing liquid to the solid phase but using respectively analogue fluids and dissolved co2 will be used in parallel pore scale concentration fields will be measured by laserinduced fluorescence and scanning by laser sheets while fluid velocities will be measured by stereopiv
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management at a distance
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multinationals mncs are key drivers of economic growth accounting for 33 of global output oecd 2018 however within mncs the economic performance of foreign affiliates declines markedly with distance from headquarters hq this pattern implies the existence of frictions that restrict how much economic growth foreign direct investment fdi can generate in host countries understanding the underlying mechanisms has important implications for the economic benefits of fdi and fdi policy yet they remain little understood in this project i propose a novel explanation management problems at a distance management problems can be severe even in purely local settings eg gibbons and roberts 2013 it is plausible that principalagent pa problems between hq and the foreign subsidiary manager rise disproportionately when different countries cultures languages and institutions are involved as previous research has been severely restricted by the scarcity of global organizational data on mncs so far there exists no systematic evidence on pa problems within mncs and how they can be resolvedi will focus on two solutions the employment of foreign subsidiary managers that have a certain connection to hq and the use of information and communication technology ict to improve monitoring problems i have been able to identify several novel data sources that can be combined to create the first comprehensive datasets on managers and ict use within multilocation firms in three historical and contemporaneous settings combined with innovative empirical approaches this allows me to provide the first tests for the existence of pa problems within mncs and study several channels through which pa problems can affect economic growth managerial compensation changes in risktaking and career incentives of middle managers i will estimate how these channels affect the economic performance of subsidiaries firms and host economies
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methods and tools for comprehensive impact assessment of the ccam solutions for passengers and goods
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mobility is crossing a new digital frontier in terms of connectivity allowing vehicles to communicate to each other to the infrastructure and to other transport systems users however the potential implications and impacts of integration of ccam solutions into the mobility system are not well understood neither for specific actors nor for the systems level move2ccam will i explore the impact of ccam passenger and freight solutions define use cases business models and kpis through cocreation activities with the satellites and ii develop a practical system dynamicsbased impact assessment tool that will enable the evaluation of ccam interventions impact on mobility socioeconomic public health and environmentalrelated aspects considering diverse european region specifics and different actors needs objectives and perceptions the satellites is a multisystems network of actors across the whole ccam ecosystem consisting of industries authorities researchers citizens and orbits around the project by participating in a series of cocreation activities case studies for different types of organisations dialogues social simulation experiments virtual reality games and av demonstrations take place in 8 european countries and at a paneuropean level to collect data and specify the multisystems impacts of ccams the impact assessment tool will allow stakeholders to test and evaluate the systemwide impacts of ccam interventions along with a range of complementary policies providing also a series of kpis within the project it is applied for helmondnl gzmpl and aegean islandsgr given these activities move2ccam significantly contributes to a wellfounded understanding of the impacts of ccams it will deliver impact evaluation frameworks and tools with kpis covering sectors such as society economy and the environment policy recommendations for ccam partnerships and largescale demonstrations and recommendations for sump
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learning intentions following evolution
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understanding why a certain utterance was said by a participant in a conversation is fundamental for successful communication to take place notwithstanding the central role of understanding intentions in communication this and other forms of pragmatic reasoning remain beyond the current stateoftheart in natural language processing nlp for this reason critical applications of these technologies such as personal assistants remain limited to few handcoded usecases such as adding events to a calendar and fail to serve as generalpurpose communicative assistants this proposal aims at making significant progress towards genuine natural language understanding nlu it introduces a system that can reason about the pragmatic meaning of a sentence by searching for useful explanations in a space that represents all possible concepts often called a language of thought because such a search process is generally intractable this project proposes to let the system discover the more efficient way to search to achieve this goal it will model an openended evolutionary process that is here hypothesized to lead to emergent exploration strategiesthis project bridges linguistics and complex systems with connections to cognitive science and evolutionary theory to maximize its success probability i will conduct it at the colt lab in universitat pompeu fabra upf a leading group in computational linguistics with a secondment at santa fe institute sfi a global leader in complexity science
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hyperconnected simulation ecosystem supporting probabilistic design and predictive manufacturing of next generation aircraft structures
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caelestis will develop an endtoend interoperable simulation ecosystem ise that will perform multidirectional dataflow across the aircraft value chain linking product design and distributed engineering teams cadcae tools to accelerate the design and engineering optimization of disruptive aircraft and engine configurations ensuring their manufacturability from the design conceptualization caelestis ecosystem will be developed to integrate interoperate and autonomously execute simulation workflows involving a variety of stateoftheart simulation tools to support the multidisciplinary design optimisation as well as uncertainty quantification and propagation across the design and manufacturing chain the ecosystem will be boosted by hpc infrastructures to massively execute predictions and deliver optimized design and engineering outputs at realistictime scales in this regard highfidelity modelbased digital twins with unprecedented level of detail and covering several production stages and manufacturing deviations will be developed and interconnected those will be linked to machine learning tools adapted to hpc simulation outputs to improve detection of manufacturing flaws based on a probabilistic approach to quantify uncertainties and their propagation and influence on structural integrity as well as identify design for manufacturing interdependencies to provide optimized product topologies from manufacturing point of view hpc simulations will be made available at manufacturing shopfloor as reduced order models in online monitoring edge computing devices to support i product performance prediction based on detected defects on real time and ii informed corrective actions to minimize and compensate their effect overall caelestis ise will contribute to generate optimized and reliable aircraft design configurations widen the design space and optimize the manufacturing process window and improve production efficiency and inline quality assurance
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nutrition place and climate nietzsches environmental ethics
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the debate on nietzsche and environmental ethics was started by max o hallman in 1991 despite underlining nietzsches affinities to ecological thought he maintained that we cannot infer any environmental ethics from nietzsches philosophy most scholars agree with hallman by contrast the main objective of this project is to demonstrate for the first time that nietzsches thought provides a coherent environmental ethics based on the notion of metabolism this environmental ethics may pave the way for a new paradigm of sustainability at the intersection between diverse disciplines such as philosophy and sociology which can mitigate the impact of the anthropocene in his intellectual autobiography ecce homo 1888 nietzsche affirms that the issues of nutrition place and climate must be placed at the centre of philosophy for nietzsche spirit itself is just a type of metabolism and i aim to demonstrate that he considered humans parts of natures metabolism with this view nietzsche i shall argue responded to the physiology debate of his time in the light of this i will address the following questions what are the most recent contributions in the field of environmental ethics what are the main positions on metabolism within the 19thcentury physiology debate what are nietzsches stances on nutrition how does nietzsche elaborate an ethics of place and how does nietzsche respond to the physiology debate of his time i will analyse nietzsches works chronologically in order to show the development of nietzsches ecological thinking i will use martin muslows method of the konstellationsforschung which examines the perspectives of the various thinkers who addressed the same problem in the same historical period regardless of whether they were familiar with similar ideas of other philosophers or not following this method i will reconstruct the debate on metabolism at nietzsches time and put it into dialogue with nietzsches works
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towards the next generation of high performance liion battery cells
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the liion battery lib market is now entering a period where energy density improvements and cost reductions are levelling off for the current generation 3a to continue with this trend while keeping pace with the increasing industry demands for cost reduction userfriendliness of electric vehicles and safety breakthrough innovations at material level and cell design are needed within this context nextcell overarching goal is to provide a new 3b lib cell generation for both high capacity and high voltage applications developing and validating a groundbreaking gellified cell concept the project workplan revolves around a three dimensionbased methodology i prototyping the gellified cell concept up to trl6 20ah ii modelling the gellified cell concept and iii evaluation of technical safety sustainability and costs improvements nextcells approach will not only provide europe with cutting edge 3b cells but will also tackle three key parameters hindering a greater market penetration of libs technology i costs optimising its manufacturing processes reducing capital and operating costs of future gigafactories by avoiding evaporation of solvents and the electrolytefilling step ii safety producing intrinsically safe cells avoiding the presence of low boiling point components in cell components iii sustainability reducing energy consumption by 50 against soa and avoiding the use of toxic organic solvents nmp the project is led by the electric vehicle industry from the project coordination by fev leading vehicle and powertrain international service provider to key industry manufacturers along the value chain such as solvay polymer binders and separators abee cathode production varta lib manufacturer or crf research centre for the fiat chrysler automobiles group thus nextcell has a solid determination towards fast and successful commercialisation of the novel cell design and its new components after the project
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adaptation to climate change in the rhizosphere across the millennia
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starting from a unique collection of paleoenvironmental samples frozen arctic soils and sediments already at awi and their corresponding ancient dna adna metagenomes that stretch back up to a million years we will retrieve information on how rhizosphere biodiversity and functionality responded to climate changes and extreme events preliminary metagenomic data from the collection suggests it is a gold mine of archaic dna that represents a timeline of adaptions to climate change in the rhizosphere by reconstructing and analyzing these ancient metagenomes and correlating with available historical climatic change data we will identify molecular adaptions that impart climate tolerance specifically resistance to increased temperature and drought this will be used to i produce and test engineered rootcolonizing bacteria pseudomonas fluorescens and pseudomonas chlororaphis that will improve climate tolerance of plants production of humidifying polysaccharides around the root facilitating the ability to grow on marginal agricultural land mal ii inform ancestral reconstruction of thermostable andor cold tolerant enzymes for industrial application and iii produce engineered pseudomonas putida strains tailored for bioproduction for the latter application we will select genes that encode biomolecules relevant for climatetolerant phenotypes humidifying polysaccharides and the biosurfactant betaines the production of these molecules using biotechnology will be targeted in the project and their application in selected industrial products verified target enduser applications will include polysaccharides and betaines for the development of 3d printed organonchip and drug delivery systems as well as the formulation of metalworking fluids lubricants and industrial cleaning products
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validation of a new drug target in nonalcoholic steatohepatitis
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this research focuses on the increasing prevalence of metabolic liver disease specifically nonalcoholic steatohepatitis nash which is driven by obesity diabetes and its related causal connections nash is a significant medical challenge with no approved treatments causing a substantial economic burden the project aims to investigate the role of oxidative stress in nash development and progression by targeting the map kinases p38 and jnk which drive the inflammatory and fibrotic aspects of nash our research could lead to new treatment approaches
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motivic integral padic cohomologies
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this project aims to study padic cohomologies of varieties using tools from motivic homotopy theory voevodskys theory of motives has played a crucial role in solving deep mathematical conjectures however motives intrinsically lack a theory of tale padic realizations in this project we will use logarithmic geometry tools to generalize the motives category and overpass this problem more specific goals are related todevelop a theory of integral logtale motives and realizations prove a general comparison between the logtale padic realizations and tame cohomologiesdevelop a theory of motives over log points with an integral hyodokato realizationsolve structural problems in the theory of motives of logarithmic schemesmipac is an innovative project in motivic homotopy theory built to impact several areas within motivic and arithmetic geometry the project will be completed at the university of milan in a leading multidisciplinary and collaborative environment i will bring extensive experience in log motives and some unique expertise on nona1invariant cohomology theories i will benefit of the experience and knowledge of the groups of algebra and geometry in padic cohomologies and motivic homotopy theory this will facilitate the research in the group and the transfer of knowledge and expand my experience and intuition transferable skills and professional networks carrying out mipac within a marie skodowskacurie fellowship will enhance the development of my career as a complete and independent leading researcher with a reinforced position within arithmetic and motivic geometry the leading position of the groups and the department will ensure a great network of international researchers with an impact to the disseminations of the ideas of mipac
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underlying models for the european digital twin ocean editomodel lab
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editomodel lab will prepare the next generation of ocean models complementary to copernicus marine service to be integrated into the eu public infrastructure of the european digital twin ocean edito that will ensure access to required input and validation data from emodnet eurogoos ecmwf copernicus services and sentinels satellite observations and to highperformance and distributed computing facilities from eurohpc for hpc and other cloud computing resources and that will be consolidated under developments of destination earth destinethe objective is to make ocean knowledge available to citizens entrepreneurs policymakers decisionmakers and scientific experts alike thus enabling them to become partners in knowledge generation explore desirable futures and develop ocean management scenarios and assemble their own twins with the overarching goal of ensuring a safe healthy and productive ocean as an interactive and user driven initiative editomodel lab will deliver a virtual ocean model lab voml including 1 a core model suite including global highresolution models and coastal configurations 2 downstream user toolkits and 3 a developers toolkit for a sustainable oceanthe voml will be an interactive and codevelopment environment to operate models edito core model suite will be based on modelling and simulation software artificial intelligence ai algorithms and specialised tools to form a new service capacity for accessing manipulating analysing and understanding marine information intermediate and downstream stakeholders will find digital tools data and information for focus applications fa that refer to the mission ocean lighthouses mols and the sustainable blue economy including whatif scenarios to find solutions to natural and maninduced hazardseditomodel lab will be delivered in 36 months by a consortium of 14 authoritative partners covering ocean knowledge modelling and technological expertise
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pension reforms and healthy ageing in italy and europe quasinatural experimental analysis of linked health and pension datasets
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the covid19 pandemic has forced many european countries to spend money that they do not have this is creating unprecedented levels of debt and will inevitably lead to pressure for retrenchment in social welfare with pensions seen as a key target while some nations will seek to protect pensions others will not how will these pension reforms impact on healthy ageing will such reforms pension save money or perversely pass costs onto healthcare and other welfare systems we propose an ambitious research programme to inform these critical questions our proposed research combines analysis of the surveys on health retirement and ageing in europe share in 19 eu countries with specific quasinatural experiment studies of pension reforms increasing pensionable ages uk 1995 pension act and italy 2011 fornero reform and reducing pension payments netherlands 2013 pension reductions and greece katrougas law 2016 additionally the project will create innovative administrativerecord linkages in italian pension and health system data to quantify occupationspecific mortalities and unequal survival times overall it builds on the pis strong trackrecord in evaluating health impacts of austerity and natural experiment research designs the anticipated findings will test critical ideas about a healthpromoting pension system and about which occupational groups may merit additional compensation due to lower survival times it will help inform critical policy debates by revealing the hidden and unanticipated health consequences of pension reforms and associated inequalities
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sponge diseases under climate change a multiomics approach to the holobionts molecular functions
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the mediterranean sea is a climatechange hotspot which is often considered a miniature model of the world ocean therefore it may allow foreseeing some of the expected global effects of climate change sponges hold numerous key roles in benthic ecosystems functioning in the mediterranean sea they create complex habitats serving as spawning and nursery grounds for fish and invertebrates and their filterfeeding activity affects entire food webs and benthopelagic couplings these keystone organisms are frequently suffering disease outbreaks and mass mortalities that are mostly triggered by marine heatwaves sponges are wellknown holobionts that host complex symbiotic microbial communitieswhile some members of these communities offer adaptive advantages others may contribute to disease outbreaks when environmental conditions changethis interdisciplinary research aims to discover the complex mechanism of thermalstressrelated necrosis and mortality of the sponge holobiont by studying the effect of heatwaves on the mediterranean bath sponge spongia officinalis through a holistic approach that includes morphological transcriptomic metagenomic and metabolomic responses of the holobiont to study causative as well as correlative disease events the experimental setting of this project will combine in situ sampling of healthy and diseased individuals as well as exposure of individuals kept in aquaria to simulated marine heatwaves these will provide the first insight not only to the change in the microbial community composition but alsoto the functionality of its members during thermal stress it is imperative to understand the mechanism of disease prevalence and mortality and to likely suggest ways to mitigate this phenomenon the expected increasing frequency of marine heatwaves can cause irreversible damage to entire ecosystems that rely on sessile invertebrates such as sponges and thus to numerous ecosystem services provided to human societies
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vault
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techniques and methods of illegally gaining access to digital information have reached new heights and are not expected to slow down so far existing solutions showed they are not able to keep data secure companies and other organisations are struggling with this issue and fail to keep up with legal regulations and face potential backlash from the public with our breakthrough solution we will tackle all existing issues concerning data protection these include encryption performance scalability and key storage issues our unique endtoend encryption technology is based on proprietary code and encryption algorithm patent pending the technology has been successfully tested on over 500 million data sets in multiuser environments as well as against existing encryption techniques for the first time there will be a tailored endtoend encryption solution for every type of organisation without any compromises in performance scalability and data security
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infectious disease decisionsupport tools and alert systems to build climate resilience to emerging health threats
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climate change is one of several drivers of recurrent outbreaks and geographical range expansion of zoonotic infectious diseases in europe policy and decisionmakers need tailored monitoring of climateinduced disease risk and decisionsupport tools for timely early warning and impact assessment for proactive preparedness and timely responses the abundance of open data in europe allows the establishment of more effective accessible and costbeneficial prevention and control responses idalert will cocreate novel policyrelevant paneuropean indicators that track past present and future climateinduced disease risk across hazard exposure and vulnerability domains at the animal human and environment interface indicators will be subnational and disaggregated through an inequality lens we will generate tools to assess costbenefit of climate change adaptation and mitigation measures across sectors and scales to reveal novel policy entry points and opportunities surveillance early warning and response systems will be cocreated and prototyped to increase health system resilience at regional and local levels and explicitly reduce socioeconomic inequality indicators and tools will be coproduced through multilevel engagement innovative methodologies existing and new data streams and citizen science taking advantage of intelligence generated from selected hotspots in spain greece the netherlands sweden and bangladesh that are experiencing rapid urban transformation and heterogeneous climateinduced disease threats for implementation idalert has assembled european authorities in climate modelling infectious disease epidemiology social sciences environmental economics one health and ecohealth further by engaging critical stakeholders from the start idalert will ensure longlasting impacts on eu climate policy and provide new evidence and tools for the european green deal to strengthen population health resilience to climate change
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twinning to address the pfas challenge in serbia
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per and polyfluoroalkyl substances pfas are synthetic chemicals widely used for more than 60 years to make plastics firefighting foams and lubricants and help create stainresistant waterproof and nonstick products however they ended up in the environment and now can be found in the soil water sediment accumulated in human bodies and represent a worldwide challenge the serbian national chemicals legislation recognizes these chemicals but none of the existing scientific or governmental institutions analyze these compounds in addition a solution to the challenge of remediation is not in sight based on a number of publications in peerreviewed journals a number of international projects and a number of students the university of belgrade faculty of chemistry ubfc is one of the leading scientific institutions in serbia this project aims to enhance networking activities between ubfc and two topclass counterparts who are leaders in pfas analysis csic from spain and innovative bioremediation of emerging pollutants brgm from france in addition this project will focus on strengthening the research management capacities and administrative skills of the grant office from ubfc this will be conducted through the development of a scientific strategy for dealing with pfas wp1 knowledge transfer in the field of analysis and bioremediation of emerging pollutants wp2 networking and promoting joint research integrating creativity and developing new approaches for pfas remediation wp3 capacity building of the ubfc grant office wp4 and through dissemination exploitation and communication wp5 the expected impact of pfastwin is to enhance the reputation research and administrative profile and networking channels of ubfc and improve its capability to compete successfully for national eu and international research funding while simultaneously benefiting partner institutions through new contacts skills and collaborations
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photonic molecule microcombs
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frequency combs are remarkable photonic devices for precision frequency synthesis and metrology the core technology behind conventional frequency combs is a modelocked laser today socalled microcombs constitute an alternative for the generation of a frequency comb on a chipscale microresonator microcombs have a frequency separation between lines that is orders of magnitude larger than standard modelocked lasers the combination of small footprint and large line spacing is opening up entirely new scientific and technological opportunities one of the most prominent ones being optical communications however one outstanding problem with microcombs is their fundamentally limited power conversion efficiency which hampers the potential applications of this otherwise promising technology in my erc cog darkcomb we have overcome this issue by developing an innovative arrangement of linearly coupled microresonators implemented with an original silicon nitride fabrication process that features ultralow optical losses the aim of this erc poc is to conduct a yield analysis of our technology investigate the freedom to operate and pursue a rigorous market evaluation these results will form the basis for the development of a sound business strategy upon the conclusion of the project
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decoding animal genomes into cell types
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the genome of an animal encodes a large set of regulatory programs that give rise to the thousands of cell types that make up its tissues and organs despite recent progress in singlecell omics our knowledge about the regulatory programs that control the establishment and maintenance of cell type identity remains limited and methods are lacking to infer regulatory programs directly from the genome sequence in this project which lies at the interface between the genome and singlecell atlases we ask how the genome sequence translates into cell types we start with drosophila as model organism its compactness allows sampling of all its cell types and developmental trajectories from egg to adult using wholeorganism singlecell multiomics thus capturing the spectrum of activation states that emerge from the regulatory genome deep learning models will be trained on regulatory sequences to predict and explain gene regulatory networks grn and grn transitions between cell states encoded by enhancers promoters transcription factors tf effector genes and feedback loops based on a better mechanistic understanding we will translate this framework to other animals including octopus birds and mammals and ask how regulatory programs evolve with a focus on neuronal diversity in the brain using new algorithms for crossspecies deep learning and combinatorial optimization we will study how combinations of expressed tfs coevolve with genomic enhancer logic we are unique in our approach because we will develop and use new technological assays deep learning and massively parallel reporter assays and combine these with perturbation experiments and synthetic biology to test our hypotheses after iteratively improving our regulatory models we ultimately aim to predict which regulatory programs and thus which cell types are encoded in an animals genome and how changes in these programs underlie changes in cell types during evolution
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glycans as master switches of b cell activity in autoimmunity
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autoimmune diseases including rheumatoid arthritis ra are often lifethreatening disorders with increasing disability having a negative impact on patients quality of life mechanisms leading to the breach of tolerance in development of autoimmunity are still largely unknown protein glycosylation is an essential regulatory mechanism in the immune system we recently demonstrated that nglycosylation of the variable region fab of autoantibodies is a hallmark of ra development and progression we also demonstrated that autoantibodies acquire these fab glycosylation signatures already many years before disease onset we herein hypothesize that fab glycosylation at the level of the b cell receptor is a key molecular switch promoting the selection activation and proliferation of autoreactive b cells leading to the concomitant breach of immunotolerance within glycanswitch we will map the fab glycome of various types of ra autoantibodies and autoreactive b cells we will study the factors and underlying cellular mechanisms that regulate fab glycosylation of b cell receptors and autoantibodies we will investigate the immunological effects of fab glycosylation and the impact in b cells signalling and activation in the context of molecular and cellular interacting partners in the immune microenvironment finally we will test in relevant mouse models how fab glycosylation of autoantibodies and autoreactive b cells contributes to the breach of tolerance we expect that the obtained insights into the role of glycans as key checkpoint for the selection of autoreactive b cells and the rise of autoimmunity will provide leads for targeted therapeutic interventions as well as rationales for the early detection of ra and autoimmune diseases in general we foresee that the knowledge generated will allow us to embark on a targeted prevention clinical study in patients at risk for ra to turn off the glycanswitch leading to chronic ra
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enhancing palliative care in icu
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about 10 of all decedents in the population die after admission to an intensive care unit icu these patients often have distressing symptoms and may receive more intense lifeprolonging treatment than they would have chosen their family members often experience lasting distress from the experience and many icu physicians and nurses are burdened by their perception of potentially nonbeneficial carethe epic project aims to sustainably improve palliative care for critically ill patients and their families in the icu an interdisciplinary consortium collaborates to provide a novel harmonized palliative care practice model using telemedicine the project is the first european interventional study on palliative care in the icu using a systemsbased approach with proactive patient identification checklist and blended learning targeted to specific requirements of icu clinicians effectiveness of the new model is assessed through a stepped wedge randomized trial with 7 clinical centers from 5 european countries 23 multidisciplinary icus and enrolment of 2001 patients primary outcome is a reduction in icu stay to relieve suffering cost implications and cost effectiveness will be assessed from different perspectives an evidencebased patient decision aid for critically ill patients is developed additional outcomes serve deepen our understanding of barriers and facilitators and provide ethical recommendations for the use of telepalliative care in civic society the vision of epic is to contribute to a mind shift from a narrow focus on prolonging life towards more holistic care a european patient and family advisory group is implemented to engage patients and family members from the start and cocreate openaccess information to increase acceptance of palliative care telemedicine offers a lowcost solution to spread the model to all regions in europe and open new avenues for patientcentered care
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advanced battery system and integration for generation4 solid state cells
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the global ev market is largely reliant on battery electric vehicles bevs that employ lithiumion liion batteries mostly based on liquid electrolytes due to extensive research and development of liion we are gradually reaching the maximum chemical potential of todays electrode materials regarding nickelrich cathodes yet liion based battery systems based on liquid electrolytes still face significant limitations due to their chemistries such as high flammability potential safety risks burning and explosions electrochemical instabilities and low ion selectivity in this regard promising solutions are emerging in the form of solidstate battery ev ssbev technology however the inherent differences between ssbs and traditional liion batteries such as fundamentally distinct operating temperatures charging rates form factor and cell safety characteristics introduce complexities in integrating them into existing bev systems necessitating a redesign of the several systems to meet this need arise will develop an advanced solidstate fourth generation gen4 liion battery system that offers advanced highperformance features based on a celltochassis concept with expandable modules that is applicable to any next generation s sbev arise will cover 3 different development paths 1 a new city car chassis design utilizing ssbs that is expandable when needed 2 a novel battery and pack level thermal management system compatible with ssbs 3 smart battery management system that controls battery expansion fast charging and safety
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quantum estimation and control for advanced noisy metrology
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in recent years the idea of building quantum technologies has quickly moved from being an intellectual curiosity to a practical reality and quantum metrology and quantum sensors are prominent ones already in use in scientific and commercial applications the underlying idea is to exploit genuinely quantum effects to perform extremely accurate measurements with a precision not achievable by classical meanswhile many important theoretical and experimental milestones have already been reached there are still many open theoretical questions left on the path to understanding the ultimate capabilities of quantum metrology especially in realistic operating conditionswe have identified three main pillars that are currently subject to very active research i understanding the ultimate limits of the quantum estimation of multiple parameters simultaneously either because all of them are of practical interest or because a full prior characterization of additional systems parameters is not possible ii assessing the impact of environmental noise on the quantum probe in particular beyond the standard assumption of uncorrelated noise iii understanding the limits of metrological schemes based on timecontinuous measurements nowadays feasible in many physical systems eg superconducting qubits optomechanics which open the possibility to perform measurementbased feedback control on the systemthe overarching goal of this action is to advance the state of the art in these three areas and to connect these three pillars by devising new theoretical tools to assess the ultimate precision limits in novel and physically relevant scenarios these tools will be rooted in quantum estimation theory and quantum control theory and they will provide fundamental benchmarks for the next generation of quantum sensors
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descending control of pain
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pain is a large societal and health problem although often thought of as an invariant representation of active nociceptors pain varies a lot under the influence of different affective states sometimes with near complete analgesia such modulation of pain is thought to occur through a descending pathway originating in the brain and to be executed by rostral ventromedial medulla rvm neurons that project to the spinal cord deciphering the complexity of the cell types involved and how they contribute to the descending control of pain has been challenging but recent advances in singlecell omics computational biology and advanced genetic technologies now open for unbiased systemwide insightsdescendpain will uncover the power of the brain to control pain we will classify rvm neuron types by singlecell rnasequencing and use scrnaseqbased stimulustocelltype mapping to identify neuronal ensembles conferring analgesia and hyperalgesia during morphine naloxone stress sleepdeprivation and exercise using activitybased mouse genetics we will reveal the full complexity of the combinations of neurons engaged and unravel their role in pain modulation thus identifying for the first time the cellular basis for how affective states modulate pain we will also use novel intersectional strategies for dual capturing of active neurons to determine how the descending rvm controls the transmission of pain in the ascending pathway of the spinal cord finally we will identify the memory substrate underlying chronic pain providing evidence for the existence of rvm neuron ensembles of chronic pain and revealing underlying cellular and molecular mechanisms this project takes a new systemwide strategy in the pain field that should fundamentally change the view of pain by providing a cellular basis for how it is continuously scaled by mental states and uncovering mechanisms of chronic pain which may provide strategies for designing effective pain therapies
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drugloaded nanobots for transmucosal delivery to mucinous tumours
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mucus is a defensive barrier that protects the underlying cells from pathogens and toxic compounds although it also hinders the delivery of drugs whenever they are administered locally there are different types of mucussecreting tumours such as pseudomyxoma peritonei pmp that could benefit from more efficient transmucosal delivery of anticancer drugs pmp is a rare disease and the most mucinous tumour type thus it will be used as a proof of concept for this project in fact it is characterised by the production of abundant mucus in the peritoneal cavity and is treated with cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy usually mitomycin c this approach has extended patient survival but there is a significant proportion of recurrence most probably due to the shielding effect of mucus therefore there is an urgent need to offer new therapeutic strategies to pmp patients recently dr palmers lab has established a collection of pmp patientderived organoids and xenografts and has shown that some pmp patients present oncogenic brafv600e mutations introducing a new druggable targeted mutation in this proposal dr snchezs lab ibec in collaboration with dr palmers research group vhio aims to use nanobots able to overcome the mucus barrier that will be loaded with mitomycin c or encorafenib braf inhibitor to treat pmp a comparative study will be performed to assess the treatments efficacy compared to the standard of care and medical advice will be received from dr lez vhuh to ensure the translation of the results to the clinic we believe that using this allinone system will certainly enhance the delivery and efficacy of the active therapeutic compound thus potentially improving current treatments
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the development of a predictive biomarker for immunotherapy outcome based on flow cytometry test
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immunotherapy has revolutionised clinical oncology with the use of immune checkpoint inhibitors icis these agents are in clinical use for almost a decade treating over 20 types of cancers they have shown a remarkable therapeutic benefit even in patients with advanced disease yet only a small proportion of patients benefit from this therapy leaving the rest resistant for reasons that are still not clear while there are certain clinical biomarkers to predict ici therapy outcome their prevalence and prediction power is rather limited therefore there is a clinical unmet need to develop more powerful biomarkers to predict response to immunotherapy in our ongoing erc consolidator grant we discovered a unique subpopulation of neutrophils present in peripheral blood that predicts response to immunotherapy in a very high probability we designated these cells as immunotherapyresponsiveness cells ircs using various mouse models we demonstrate that the levels of circulating ircs measured at baseline are significantly higher in responding tumours to ici therapy these results were confirmed in a limited number of nonsmall cell lung cancer nsclc and melanoma patients hence our aim is to further test irc levels in clinical samples to evaluate their predictive power for ici therapy and to develop a clinical liquid biopsybased predictive biomarker using flow cytometry test the development of clinical irc detection based on flow cytometry bioflow can serve two markets 1 clinicians enabling oncologists to easily predict response to ici therapy thus improving personalised immunotherapy treatment and 2 pharmaceutical companies developing immunotherapies that can use irc detection in development stages and through clinical studies enabling tight regulative assessment of rd success rates the bioflow goal is to technically validate and develop a predictive biomarker platform for both markets that will lead to its commercialisation
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realtime monitoring of earthquake nucleation for faults near urban areas
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a longstanding lingering question in geoscience is whether earthquakes show a precursory nucleation process precursory signals from wellrecorded large earthquakes displayed widely different amplitude or duration and some large earthquakes displayed no detectable precursors the main objectives of quakehunter are 1 to determine the most effective approaches to detect faultrelated transients preceding moderate to large earthquakes and 2 to monitor seismic and aseismic processes and infer from them the fault conditions under which earthquake nucleation processes emerge and the optimal instrumentation required to capture them to achieve these we will develop different methodologies based on a combination of supervised and unsupervised artificial intelligence to identify retrospectively earthquake nucleation processes for active faults near earthquakethreatened urban areas the ultimate goal will be to test the performance of this novel earthquake forecasting methodology in nearreal time we will analyze data from northwestern turkey where the north anatolian fault is overdue for a magnitude m7 earthquake directly adjacent to the istanbul megalopolis with its 15m inhabitants the groundbreaking part of quakehunter is that if earthquake nucleation processes could be discerned prior to large earthquakes in the marmara region then automated nearrealtime detection could provide extended warning and preparation time if successful this could become in the future an essential ingredient for activating civil protection protocols to mitigate seismic risk quakehunter aims at having a strong scientific impact on earthquake physics we will be able to refine our knowledge on the physics of earthquakes shortly before their start as well as the fault conditions favoring the identification of earthquake precursors the firsttime testing of such methodology in realtime will have a strong societal impact potentially advancing earthquakes forecasting
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new endtoend digital framework for optimized manufacturing and maintenance of next generation aircraft composite structures
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genex project aims at developing a novel endtoend digital twindriven framework based on enhanced computational models which embed the interdisciplinary knowledge of the aircraft components and the manufacturingrepairing processes to support the optimized manufacturing of composites parts enable the continuous operation of aircrafts and improve the composites repairing processes for ensuring aircrafts safety and airworthiness first automated atl process coupled with thzbased inprocess monitoring together with hybridtwin simulation methods will be developed for ecoefficient and advance manufacturing of innovative reprocessablerepairablerecyclable 3rresinand stateoftheart thermoplastic composites second innovative data and physicsbased machine learning algorithms for damage detection and location combined with advanced highperformance computing hpcbased multiphysics and artificial intelligentpowered digital twin tools for fatigue life prediction will be implemented to transform information from optimized onboard piezoresistive sensors data networks interfaced with lowpower wireless communication platform to health and usage assessment and prognosis third augmented reality tools together with novel laserassisted methods for surface cleaning and monitoring smart monitoring and insitu tailored heating of composite repair blankets will be further developed to provide additional assistance in manual scarf repair operations increasing reliability of repair process while supporting the modification and virtual certification of mro practices thus a novel digital twindriven framework will be implemented into a common iiot platform to integrate the developed models and data acquired providing bidirectional dataflow and enabling the implementation of a holistic and comprehensive data management methodology ensuring to adequately create capture share and reuse knowledge along the entire aircraft lifecycle
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recycled metals for aboveground hydrogen storage
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the main objective of remedhys is to advance the maturity of aboveground solidstate hydrogen storage solutions based on metal hydrides with hydrogen chemically bounded to the metals and operation at ambient conditions this is a compact and safe hydrogen storage method and with significant advantages compared to both compressed and liquid hydrogen storage solutions the hydrogen storage system in remedys with capacity of 100 kg h2 will operate at a pressure below 50 bar the metal hydrides will be produced from lowcost recycles metals sourced in europe and then minimizing the needs to import critical raw materials to europe the modular hydrogen storage system will be validated in an enduser scenario with a 2 mw pem electrolyzer and supplies of hydrogen to a hydrogenpowered offshore service supply vessel remedhys will contribute to implementation of regulations codes and standards for largescale aboveground storage systems for solidstate hydrogen storage systems the project will also address sustainability and circularity aspects by employing a life cycle assessment and make recycling of critical raw materials as an integrated part of the materials development the remedhys consortium consists of the leading research institutions in europe on solidstate hydrogen carriers four research centers and two universities and four partners from the industry remedhys will build on the experiences from the eu funded project hycare 20192023 which had six of the remedhys partners
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realizing healthcare 40 exploiting the 6g network evolution
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elixirion will create the first fullyintegrated inter and multidisciplinary highlyinnovative training and research network that will set the foundations of the emerging healthcare 40 paradigm by leveraging 6g technologies targeting to i provide all citizenspatients with a wide range of services of different requirements such as ultralow latency for latencycritical applications high speed for data hungry services and ubiquitous secure access to healthcare resources anytime anywhere respecting all privacy aspects and ii ensure a secure efficient and profitable healthcare ecosystem to all involved stakeholders while creating a sustainable open market easing access to new players to achieve the aforementioned objective elixirion will 1 leverage a gamut of 6g technologies towards a powerful interconnected network for ultrahigh performance access to the healthcare ecosystem targeting up to 9999999 reliability 100 coverage down to subms e2e latency up to 1 tbps capacity high energy and costefficiency while supporting a massive number of connections 2 design edgeaware algorithms leveraging diverse computing capabilities offering ultrafast task execution through parallelization serverless and distributed computing by intra and inter edge node orchestration techniques for realtime mission critical healthcare applications 3 provide an e2e slicing and zerotouch orchestration framework for optimized 6g network performance across the healthcare ecosystem targeting at full network automation and secure information handling especially when a massive number of medical devices is considered by leveraging aiml while considering all different network parts and data analytics to derive useful information helping in the decisionmaking process and 4 create a sustainable healthcare ecosystem and new business models leveraging blockchainbased incentive engineering for secure incentivized collaboration among the involved stakeholders
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flux race investigation for dissection of metabolicbottlenecks leveraging the tremendous potential of algal metabolic diversity
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a 70 increase in food production is required to feed the world population by 2050 putting increased productivity on a collision course with environmental and sustainability goals aiming to meet this growing demand photosynthesisrelated pathways are regarded as a promising target for crop improvement to increase agricultural yield however they remain mostly unexploited furthermore while empirical studies have shown that photosynthetic efficiency is higher in microalgae than in both c3 or c4 crops the underlying reasons remain unclear identifying metabolic bottlenecks in photosynthetic cells remains a holy grail of plant research however with recent progress made in crosskingdom plant flux analyses the time is ripe to tackle photosynthetic metabolism with stateoftheart experimental and computational approaches as a target for plant yield improvement in this project i propose to address the following key questions 1 what role is played by photosynthetic metabolism in setting the upper limits for growth of photosynthetic cells and in this respect 2 what makes some photosynthetic cells grow faster than others we will combine cuttingedge tools for comparative flux analyses with genetic approaches applied on algae and higherplants to identify and validate metabolic bottlenecks for plant growth as targets for crop yield improvement these research aims fall well within my unique set of expertise ive characterized the metabolism of the fastest growing photosynthetic cells and mapped the metabolic networks of algae compared with c3 and c4 plant models using a novel microfluidics setup which i developed facilitating nonstationary stable isotope analysis at steady state conditions in liquid algal cultures successful outcome of this project will shed light on the magnitude of photosynthetic metabolism effects on plant growth and help reshape the field of targeting photosyntheticrelated pathways for cropplant yield improvements
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green materials for neuromorphic signal processing by organic synaptic transistors
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electronics today cause major environmental impacts through manufacture use and disposal as well as growing concerns about europes economic and technological dependence on other regions of the worldthe overall objective of greenomorph is the radical reduction of the environmental impact of electronics manufacture use and endoflife as well as a total avoidance of critical raw materials in manufactured devices we attack this goal on the one hand by choosing neuromorphic instead of common von neumann computing reducing the energy consumed during use by several orders of magnitude on the other hand we completely rely on organic electronics with innovative green materials and additive lowtemperature manufacturing by blade coating screenprinting and inkjet printing in all parts of an organic artificial sensory neuron for recognition of tactile pressure patterns the parts of the neuron as there are an organic tactile sensor organic signal conditioning circuits and organic artificial synapses as well as the neuron itself are validated outcomes of the project and contribute to the project portfolio of responsible electronics already during their development the outcomes of the project will help to replace a performanceatanycost attitude yet staying fully aware that developing nonperforming devices not accepted by users would have a great environmental impact as well so performance targets and market analysis are equally important as the low environmental impact targets and social life cycle assessment areshowing that it is possible to fulfil a given purpose at an environmental footprint orders of magnitude smaller than today and at the same time reduce dependence on other regions of the world our lowenvironmentalfootprintfirst approach will serve as a reference in the future from scientific communities to technology developers and manufacturers through to the end users
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digital and physical incremental renovation packagessystems enhancing environmental and energetic behaviour and use of resources
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aegirs main objective is to demonstrate a scalable industrialised smart nonintrusive quick and affordable fourpackaged renovation solution to boost the take up of deep retrofitting achieving nearly zeraegir main objective is to demonstrate a physical and digital sustainable framework that boosts the take up of deep retrofitting achieving nearly zero energy buildings this approach is supported by i innovative industrialized high performance and nonintrusive multifunctional plugandplay envelope solutions to increase the use of locally deployed renewable technologies these solutions can also be modulated depending on the requirements of the target buildings ii a digital ecosystem of services to improve the whole construction workflow from design manufacturing construction and operation reducing costs with a sustainable approach and iii a socioeconomic model providing financial schemes and business models at building scale to demonstrate these objectives the project will deploy all these solutions in four demos spain france denmark and romania mixing the retrofitting actions which will use the solutions in four different climates the demos combine different building typologies multifamily buildings educational buildings offices and singlefamily buildings to proof the concept in buildings and tenants with different requirements one of the demos denmark is social housing so the intention of the project is to demonstrate that these solutions are feasible for the more demanding public a second demo is a public school to demonstrate the improved air quality and comfort provided by the solution to solve many of the air qualityventilation problems in this type of buildings the project involves all the actors from the construction and energy management value chain with local and international smes large companies public authorities local and international clusters are also included to verify the developments at european level
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celtic and latin glossing traditions uncovering early medieval language contact and knowledge transfer
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glosses are fingerprints of the society in which texts were composed copied and read most importantly they play a much more significant role than previous research has acknowledged and offer insights about the multilingual and multiethnic environment of medieval manuscript and text production the principal texts cannot they are firsthand testimonies of the close linguistic and cultural contacts between insular celtic old breton old irish old welsh and latin speakers glossit researches this largely neglected source for early medieval linguistic and intellectual exchange in western europe this comparative study on the vernacular insular celtic and latin glosses shows that the interlinear and marginal glosses or paratext of 9th10th century manuscripts have a marginal character only at a first glancea striking lack of editions has so far been a strong obstacle for indepth investigations glossit addresses this shortcoming and produces digital editions to research the interrelationships between the languages involved ie latinvernacular and intravernacular contact as well as the knowledge transfer observable in early medieval glossing traditions it tackles this issue through combining methods of comparative philology and historical linguistics digital humanities handwritten text recognition network analysis natural language processing cultural history and in a firstofitskind approach biological computation applying dnasequence alignment methods to glosses the core sources are early medieval copies of the computistical works of bede and priscians latin grammar with multiple manuscript witnesses transmitting insular celtic and latin glosses for the first time glossit puts their glossing traditions at the centre of a largescale investigation into language contact and knowledge exchange between the celticspeaking world and the carolingian empire in an era that was foundational for europes intellectual history until today
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universal building blocks for antigen presentation to uncover the flavivirusdirected antibody response
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flaviviruses are a tremendous burden on global public health the genus consists of yellow fever virus dengue virus and zika virus amongst others these viruses threaten more than half the global human population and are spreading into new territories the recent zika virus pandemic stresses the need for a suitable protein engineering toolkit to enable swift development of emerging flavivirus antigens for structural studies serology and vaccine development moreover the structural determinants of a neutralizing polyclonal antibody response are currently not well understood in large part for a lack of suitable methods to address the complex interactions of multiple antibodies directed against a heterogeneous glycosylated viral antigenwith flavir i will use my unique expertise in both mass spectrometry and electron microscopy to develop a comprehensive structural proteomics toolkit for indepth profiling of the neutralizing antibody response against flaviviruses using a combination of novel mass spectrometrybased antibody sequencing techniques glycoproteomics profiling and electron microscopy we will uncover how the polyclonal antibody response against flaviviruses is directed by key structural determinants of the envelope glycoprotein that is displayed on the surface of infectious virionswe will develop new strategies to produce prefusion stabilized edimers and ultimately reconstruction of full icosahedral flaviviruslike particles from soluble components the outlined strategies will be tested and streamlined for broad applicability across the flaviviruses so that it can be swiftly adapted for emerging species and strains we will characterize our designs with stateofthe art mass spectrometry methods native ms mass photometry hdxms and electron microscopywe will use these optimized antigens to uncover the role of antigen glycosylation in antibody binding profile the serum antibody repertoire directed against the eantigen and map ou
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novel photocatalysts based on ferroelectric high entropy oxidemetal nanoparticle composites
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ferroelectric high entropy oxides fheos are a novel type of ferroelectric material with the simultaneous existence of configurational entropy and internal ferroelectric polarisation these effects combined with intrinsic lattice distortion and uneven electroncloud distribution of high entropy oxides can lead to the generation of multiple active sites with improved separation of charge carriers significantly impacting different photocatalytic reactions such as pollutants degradation and water splitting furthermore the visiblelightdriven photocatalytic activity of fheos can be secured by the decoration with plasmonic metal nanoparticles mnps efficiently harvesting visible light due to their localised surface plasmon resonance lspr thus our strategy is to synthesize an entirely new fheo and decorate it with plasmonic mnps to produce a novel material with improved charge separation and visible light absorption which will contribute to a major step forward in the catalysis field the produced materials will be fully characterised and the photocatalytic efficiency will be evaluated over the degradation of pollutants present in wastewater and in the water splitting process
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robust control of the space debris population to define optimal policies and an economic revenue model for the sustainable development of space activities
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space assets offer services of social and economic benefit for the humankind and enable monitoring the condition of our planet as recognised by the un and space agencies space missions for earth observation geolocation telecommunication science and technology contribute to the achievement of the sustainable development goals as our lives become more and more interconnected thanks to satellites and space is more easily accessible space can be seen as the extension of our planet biosphere as such longterm sustainability of space activities will be possible only if a change of behaviour is put in place by space faring nations the growth of space debris is following an exponential trend which is typical of many other environmental stressors of earth system trends immediate actions are needed to mitigate the increasing risk of collisions and enable the future use of space as a common in green species project i will devise a new interdisciplinary framework for the modelling of the space debris population and the forecast of its evolution a probabilistic space debris model will be devised for the overall space debris environment all uncertainties of physical economic and political nature will be modelled and the forecast of future launch traffic and compliance to guidelines included via economic approaches and evidence theory as unique feature the project will incorporate the management of the debris environment through a robust timedelayed controller applied to the space debris model described as a complex dynamical system ideal feedback control actions will be transformed into policies and guidelines via quantitative indicators assessing both the environmental impact and the social and economic benefit of space missions policies will act as the actuator of a real controlled system green species will propose the first economic model for a revenue system for sustainable space by leveraging approaches from the management of the global climate
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unified cosmology across lensing surveys
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according to the current consensus cosmological model dark matter and dark energy make up most of the energy density of the universe however their physical nature is still unknown and understanding them presents a grand challenge moreover there are unresolved tensions between observations from the latetime and the earlytime universe intriguingly all weak lensing analyses favour a smoother matter distribution than plancks cosmic microwave background observations in order to assess if this discrepancy is due to unaccounted systematics or new physics it is essential to analyse the existing weak lensing datasets with a unified pipeline this effort is especially required as we approach the next generation of dark energy surveys including esas euclid mission the vera c rubin observatory legacy survey of space and time and the nancy grace roman space telescope since they will provide unprecedented highquality data that will increase the statistical power by orders of magnitude in this project we will combine for the first time the final data sets from the current generation of dark energy surveys des kids and hsc to obtain competitive cosmological constraints from the joint analysis of galaxy clustering and weak lensing for this purpose we will develop a novel unified modelling and inference pipeline to fully exploit the statistical power of the different surveys in an optimal way the methodology developed and employed in this project will be crucial to shed light on the existing tensions with planck and the nature of dark energy with esas euclid mission the rubin observatory and the other upcoming dark energy surveys
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affective vlomobilities of care a gendersensitive approach to sustainable mobility
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within europe women spend up to twice as much time on unpaid care work as men do and mobility related to care tasks represents a significant part of womens daily travel escorting children tends to be unequally distributed amongst parents and they are much more likely to travel with their mothers than with their fathers by introducing the novel concept of affective vlomobilities of care that focuses on the use of bicycle for accompanying children to their everyday activities velocare addresses a critical research question that is often ignored in most cities how does the urban environment either contribute to or exacerbate gender disparities by facilitating or impeding the mobility of women who escort their children through the implementation of a policyoriented interdisciplinary approach and innovative methodology that builds on sensory data the research examines the broader implications of these dynamics on the emotional bonding of the mother and child and on womens choice to adapt cycling as an environmentally sustainable mode of transportation in tallinn estonia putting emphasis on the soft aspects of everyday travel the research will advance knowledge that will help put affect and care at the centre of mobilities planning and make cities more inclusive of the needs of women and children
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phenomenology of bmeson semileptonic inclusive decays from the standard model to the new physics
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semileptonic bmeson decays proceeding via bc and bu transitions are processes widely studied in the standard model sm of particle physics measurements from b factories and the lhc have been used to determine vcb and vub two of the elements of the cabibbokobayashimaskawa matrix and as such crucial input parameters of the sm there is a longstanding tension affecting both vcb and vub determinations from inclusive and exclusive decays and significant hints of lepton flavour universality violation in semileptonic b meson decays with tau leptons in the final state and rare decays mediated by the bs transition their possible origin from new physics np beyond the sm has been broadly scrutinized in the context of exclusive decays however inclusive b meson decays have never been used as competitive probes of np in this project we will establish the theoretical foundation for the study of nonstandard interactions in inclusive semileptonic decays driven by bc and bu transitions we will perform a comprehensive modelindependent analysis of the constraints on np from this class of decays including for the first time all available data on kinematic differential distributions we will investigate the implications for viable scenarios of physics beyond the sm and present their interplay with the exclusive modes disentangling lowenergy nonperturbative effects from np effects is challenging and requires addressing new issues making the proposed action interdisciplinary and innovative the researcher matteo fael has a broad experience in the theory and phenomenology of inclusive bmeson decays while the supervisor gian francesco giudice is a worldclass expert in flavour and collider phenomenology development of np models and study of their implications for particle physics and cosmology
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satellite and terrestrial access for distributed ubiquitous and smart telecommunications
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5g evolution is expected to deliver services to a diverse gamma of verticals and to the overall society according to a anywhere anytime anydevice paradigm hence calling for a polymorphic and flexible architecture such an ambitious deployment plan calls for the convergence of terrestrial and nonterrestrial networks especially for providing connectivity to underserved areas which is the motivation of 5gstardust5gstardusts ambition is to is to deliver a fully integrated 5gntn autonomous system with novel selfadapting endtoend connectivity model for enabling ubiquitous radio access importantly leveraging on 1 new highly flexible multiconstellation multiorbit architectures integrated with 5g terrestrial segments 2 fully 5gcompliant regenerative satcom capabilities 3 unified radio interfaces 4 data driven aibased techniques for multiconnectivity and radio resource management tasks 5 3gpp and oran architecture and conceptsto this aim 5gstardust will design develop and demonstrate up to trl 5 a flexible satellite system integrated with the terrestrial infrastructure by means of selforganised network architecture this allows for autonomous and intelligent multiconnectivity framework able to adapt to diverse vertical requirements this innovative framework will also support the operation of multiorbit constellations with transparent and regenerative space nodes to deliver 5g6g ntn services5gstardust positions itself in the worldwide 5g6g ecosystem timeline development both from the standardization and market perspective from the global standardization perspective 5gstardust results are planned to support nonterrestrial network inclusion in the 3gpp release 19 on the basis of the results of release 18 and to influence initiation of activities in 3gpp release 20 and 21 from the deployment and market perspective 5gstardust lines up with the market introduction ie deployment by mnos of the 3gpp release 16 17 and 18
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literature for empowerment against manipulation
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life examines if and how literary reading can be used to help raise awareness of disempowering manipulative influences exerted by ones environment and the media and foster empowerment to mitigate their effects it will develop a new crossdisciplinary tool to measure literatures potential effects on manipulation perception and on the sense of empowerment it will provide an empowerment canon of expertselected and empirically validated literary texts that can be particularly helpful in this task the tool will draw from the disciplines of literary studies psychology sociology and communication and will be empirically tested and validated in two diverse countries italy and the united states the media and the environment can exert disempowering influences on ones life indeed the news advertising gaming and social media industries often propel insecurity social division consumerism and addictive behaviours while ones immediate environment may imbed limiting beliefs and conformism while the empirical study of literature has been able to show some of literatures prosocial effects its potential impact on kindling the sense of empowerment is yet to be determined life tackles this challenge by researching how literature can help raise awareness of such disempowering manipulative influences and foster empowerment life will advance the emergent interdisciplinary research area of the empirical study of literature
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lysosomal exocytosis of metastable proteins to control synaptic function
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the extreme length and small caliber of neuronal processes entail complex local regulation of protein turnover in light of the high metabolic demand and dynamic protein exchange imposed by synaptic neurotransmission several surveillance mechanisms should be in place to sense protein damage that will otherwise cause synaptic dysfunction however it is still essentially unclear how local control of the metastable proteome whose proteins have a high copy number and are crucial for synaptic function is accomplished in dendrites to prevent formation of toxic aggregates my previous work suggests that neuronal activity drives lysosomal fusion with the plasma membrane and exocytotic release of supersaturated aggregationprone proteins the deposition of these proteins in the interstitial space likely feeds into the glymphatic system and cleaning routines associated with the enhanced circulation of cerebrospinal fluid during sleep intriguingly i could show that the concomitant release of lysosomal proteases enables growth of spine synapses suggesting that lysosomal exocytosis might serve both protein removal and synaptic plasticity whereas the latter might be an inevitable consequence of the necessity for local disposal of aggregationprone proteinsbuilding on my expertise in synapse biology and advanced imaging the lexsyn project aims to characterize the secretome of exocytotic lysosomes and to understand the consequences of dendritic lysosomal fusion for synaptic plasticity i will decipher physiological signals regulating lysosomal exocytosis and investigate the pathological consequences of lysosomal fusion impairment thereby assessing its relevance in neurodegenerative diseases to achieve these ambitious goals i will develop new tools for monitoring and manipulation of dendritic lysosomal exocytosis in vivo i expect to reveal mechanisms of fundamental relevance for the control of the metastable proteome and its contribution to neurodegeneration
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towards loop splitting amplitudes and collinear factorisation breaking
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the groundbreaking discovery of the higgs boson at the large hadron collider rang the bell for the beginning of a new era of particle physics naturally the ever increasing precision data from experiments demand precise theory predictions for many observables to test the ultimate validity of the standard model sm any significant deviations from the sm predictions will hint for new physics quantum chromodynamics qcd being the most fascinating nonabelian gauge theory provides a promising platform in achieving this goal through higher order perturbative computations in powers of the strong coupling process independent singular elements associated to qcd factorisation of scattering amplitudes in both soft and collinear limits also known as splitting amplitudes are the key elements in organising and automating these higher order calculations for the theory prediction of a general jet observable so the high relevance of these splitting amplitudes strongly motivates the researcher for an ambitious proposal on further improving their theoretical accuracy in particular through this proposal the researcher will investigate the softcollinear splitting amplitudes required to predict a jet observable at nexttonexttonexttoleading order n3lo the researcher will also be exploring the intriguing concepts of collinear factorisation breaking and its effect on the prediction of an experimental measurable quantity upon successful this project will contribute to the purpose of bringing down the theory uncertainties to 1 level together with many new ideas and techniques which will assist the researcher to create an independent future career and contribute to tighten the grip on n3lo calculation tools
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social economy enterprises for development and democracy
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eroding liberal economic model and democracy require novel approaches to development cooperation the new research agenda emphasises the need for more research on the interactions between the nationstates policies and organisational models soeco4dev aims at responding to these policy and theoretical debates by providing an original and innovative approach and multilevel perspective to understanding the role of the local bottomup institutions to uphold democratisation and development in postcommunist countries the objective of soeco4dev is to analyse how the emerging phenomenon of social and solidarity economy sse organisations drive social innovations and change in three distinct dimensions of sse entrepreneurial culture economic dimension solidarity bonds social dimension and democracy promotion governance dimension the research focuses on the nascent entrepreneurial forms of sse social enterprises se in two postsoviet republics georgia and kyrgyzstan that continually strive to develop and democratise their societies soeco4dev project is marked out by its ambitious and interdisciplinary nature that contrasts nationstate and organisational levels and carefully integrates research and policy local and global perspectives the project is underpinned by an innovative and robust methodological approach that aims at constructing a wellgrounded theory of sses internationalisation in underexplored country contexts the project is particularly timely in the context of conflicts and increasing inequalities as it aims at gaining an indepth understanding of the new forms of social organising and their capacity to complement the traditional local development actors such as civil society organisations and the private sector soeco4dev also aims at the career development of the researcher broadening her research areas and improving her qualitative research and publication skills to obtain a permanent teaching and research position in the eu
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building decentralised distributed and local microgrids for decarbonisation electrification challenge
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the ideal4green project addresses the urgent challenges of climate change and the global shift towards sustainable energy systems it focuses on developing and integrating microgrids which are crucial in managing the variability of renewable resources and achieving decarbonisation targets the project aligns with the ecs commitment to carbon neutrality by 2050 by empowering energy communities and optimising local supply and demand the project proposes a comprehensive doctoral training network aimed at developing skilled engineers with interdisciplinary and intersectoral expertise this network diverges from conventional universitybased research maintaining strong industry links and emphasising practical implementation ideal4green consists of 8 beneficiaries and 11 partner organisations recruiting 15 doctoral candidates to undertake research on microgrids planning design operation control and impact assessment the research encompasses innovative frameworks and methodologies for integrating microgrids and transforming traditional grids into sustainable energy systems this includes developing advanced control algorithms cybersecurity improving mechanisms for microgrid islanding and reconnection and enhancing the resilience and reliability of interconnected microgrid systems the project also explores the planning policy and economic feasibility of interconnected grids and microgrids it emphasises creating complete and integrated microgrid design frameworks utilising integrated energy system modelling and investigating regulatory policies in terms of training the dcs will engage in a mix of academic and industrial experiences including secondments and networking meetings ensuring their exposure to both theoretical knowledge and practical skills the training program covers various aspects such as advanced technical skills collaborative communication critical thinking problemsolving and adaptability
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the origin and evolution of a blastered mercury
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mercury is a metalrich planet from which earthbased and spacecraft data were collected our understanding of its interior structure and thermochemical evolution is however still relatively poor this is due to 1 large uncertainties on its polar moment of inertia and surface composition this will be largely improved by the bepicolombo mission 2 an unknown bulkplanet composition and 3 a poor knowledge of some key thermophysical properties eg phase stability temperature density of solidliquid metals and silicates inside mercury this is because under mercurys reducing conditions elements behave differently than on other planets currently available phase diagrams for the moon and mars are thus irrelevant for calculating the compositions and physical properties of mercurys core mantle and crust improving such constraints is critical but requires new experiments under hitherto unexplored conditions they will be done in ironheartso far it was largely neglected that many compositional features of mercury are inconsistent with its direct accretion as a small metalrich planet ironhearts working hypothesis is that mercury is merely the remnant of a larger martiansized chondritic planet which we call protomercury involved in collisions having stripped away much of its mantle this process did eventually set the final composition of modern mercury for the first time ironheart will evaluate experimentally how protomercury controlled the core and mantle compositions of modern mercury further experiments on these compositions will provide phase equilibria of mercurys internal layers allowing us to calculate their thermophysical properties by combining those with bepicolombo data into thermal and geophysical models we will provide a clearer than ever picture of mercurys structure and evolution ironheart will also be critical to understanding dense exoplanets and the earth which accreted from similar building blocks as mercury
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userdriven health risk assessment services and innovative adaptation options against threats from heatwaves air pollution wildfire emission and pollen
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transformative adaptation is gaining recognition as the appropriate response to climate change as the current adaptive measures reach their limits in addressing health risks associated with heat waves air pollution wildfire emission and pollen the implementation of comprehensive transformative adaptation remains largely unreported in europehealthriskadapts objective is to develop and implement a health risk assessment system for mediterranean alpine and continental regions its contents and tools will be in line with climateadapt described urban adaptation support tool this will support empowerment of local and regional authorities to make informed decisions in strategic planning management and daily operational mitigation of health challenges related to climate changehealthriskadapt will address the fundamental causes of vulnerability and implement concrete adaptation measures aiming to mitigate the health impacts of climate change the key details of this approach include 1 cocreation with users of integrated transformative adaptation options encompassing technical nature based and social solutions reducing the impact of climaterelated risks on human health in both indoor and outdoor environments 2 vulnerability assessments health indicators and risk indices related to climate change impact on health considering different temporal and spatial scales3 interactive and userfriendly toolkit for local regional authorities to assess hazards vulnerability and risks specific to their regions these toolkits will facilitate the prioritization planning and evaluation of adaptation optionshealthriskadapt will use various communication techniques to actively engage with all stakeholders involved in the adaptation process and develop an upscaling strategy to meet the ambitions of the climate mission furthermore we seek to enhance the preparedness of the healthcare system to respond effectively to the challenges posed by the effects of climate change
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macrophagebased immunotherapy of platinumresistant ovarian cancer
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resistance to platinumbased chemotherapy is a major clinical challenge in ovarian cancer about 300000 women are diagnosed with ovarian cancer each year and the number of deaths is estimated at 180000 worldwide each year ovarian cancer metastasizes early in its development often before its diagnosed ovarian cancer treatment involves surgery with frontline platinumbased chemotherapy as many as 1530 of patients with ovarian cancer have primary platinumresistant or refractory disease the recurrence of ovarian cancer is now considered a sign of an incurable disease it becomes platinumresistantthe project macov aims to develop an innovative allogeneic readytouse macrophagebased therapy for platinumresistant ovarian cancer this is a groundbreaking first in class therapy that shows very high efficacy in multiple solid tumors of unmet medical need these cells are equipped with targeted therapy drugs complexed with the carrier protein ensuring their stability in the carrier cell the proteindrug complex is transferred specifically to cancer cells the whole concept of this cell therapy is based on the groundbreaking scientific discoveries of mdc macrophagedrug conjugate two european research council erc grants were received to study the molecular basis of the discovered mechanism in 2016 and 2020 in 2018 this project was selected to be promoted as one of the 10 european projects during erc 10th anniversary the macov project will generate of complete efficacy data package for the preclinical development of mdc735 product consisting of efficacy in multiple animal models for platinumresistant ovarian cancer pk pd and toxicology study as well as consolidate ip and validate business case the result of the project will be a validated cell therapy product for platinumrefractory ovarian cancer tested for effectiveness and readytouse for the phase i clinical trial
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improving yields in organic cropping systems
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with the european green deal the farmtofork and biodiversity strategy the eu aims to achieve the target of at least 25 of the eus agricultural land under organic farming by 2030 this means tripling the current organic farm area with estimated 700000 farmers expected to enter the organic sector one of the obstacles hindering conversion to organic farming is the lower yields per hectare grown under organic conditions as compared with those produced under conventional farming therefore improving organic yields is a key challenge of the organic sector which however needs to be achieved on the basis of the principles of organic farming against this background the overall aim of the project is to contribute to a sustainable increase in yields in organic cropping systems through a comprehensive and structured compilation and evaluation of existing knowledge devising sustainable impact strategies relevant to stakeholders and policy the project will set up an europeanwide network of testing experimentation and demonstration sites from 11 regions countries representing a wide range of pedoclimatic and structural conditions it will connect actors from science and practice to jointly reflect on organic yield increase strategies it will draw recommendations for the future research agenda and development of eu policies relevant for organic production the outcomes of the project will be widely available and disseminated to actors within and beyond the organic community
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resilience quantification and enhancement of energy system operations with hydrogen integration
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hydrogen has emerged as the primary energy source for european countries to pursue net zero however due to the lower heat value compared with natural gas the integration of hydrogen can substantially reduce the flexibility of the energy system rendering it more vulnerable to extreme operating conditions with various prospective hydrogen integration pathways adopted by different countries this project aims to answer two key questions will hydrogen integration make the energy system less resilient and if so how to mitigate these side effects hence the project will be conducted in five essential steps physicalinformed extreme scenario identification flexibility quantification resilience mapping resilience enhancement and realtime validation multidisciplinary knowledge including electrical mechanical environmental and civil engineering will work collaboratively to ensure comprehensive research outcomes various open science practices dissemination activities and training initiatives will be implemented to increase the impact and refine the scientific and transferable skills of the researcher the expected results of this project will firstly address the resilience issues of hydrogenintegrated energy systems contribute to a reliable energy transition in europe and solidify europes leading position in the global hydrogen industry
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sustainable wellbeing through investment in social services
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swins will develop and test a policyoriented toolbox for the exante assessment of the economic and social returns of investments in social services over the life course focusing on the complementarity of services aimed at developing human capabilities throughout the lifespan it will explore the impacts of alternative social policy scenarios entailing different social services configurations from maternal care and ecec to education and almp up to longterm care swins will conceptualize the returns to social services in terms of income employment and growth as well as bridge knowledge gaps about how these investments influence macroeconomic stability and foster the eu sustainability transition performances by implementing a rightbased social investment approach swins aims to support the rethinking of social services as drivers of the eus shift towards sustainable wellbeing going beyond their role as mere safeguards against the transitions side effects swins methodology will be based on three main steps 1 the identification of macroregularities that is the relation between investment in social services and aggregate socialeconomic performances 2 analysis of the microfoundations that is the analysis of the microlevel mechanisms that explains the macroregularities 3 macro and long term projection of the results swins will rely on a variety of methodologies ie microsimulation analysis using the euromod platform and its expansions synthetic panels causal analysis of comparative microdata machine learning techniques and macroeconomic agentbased models leveraging the expertise of a multidisciplinary law economics sociology political science consortium swins will explicitly pursue impact by proposing concrete strategies to integrate research findings and tools into the institutional legal and policy frameworks
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controlling cavitation for the activation of small molecules
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sonochemistry is the use of ultrasound to facilitate chemical reactions chemical reactions requiring stringent conditions can be effectively carried out using sonochemistry at ambient conditions the current state of sonochemistry is limited by the low efficiencies in converting electrical energy to cavitation energy for free radical generation this makes the application of ultrasound for chemical synthesis an expensive technique in terms of energy per productivity controlling cavitation with novel catalytic cavitation agents cca to reduce energy requirement for inertial cavitation will open a new paradigm for sonochemistry potentially impacting the catalytic chemistry acoustic and sonochemistry communities and opening opportunities to address challenges faced by chemists in sustainable chemicals synthesis the objective of my project is to systematically progress towards deep understanding of cavitation bubbles generation through insitu observation approaches engineering of multifunctional catalytic cavitation agents and machine learning this will exert better control on the formation uniformity and collapse location of cavitation bubbles thereby significantly reducing acoustic energy requirement for inertial cavitation i will synthesize multifunctional transition metal oxides catalytic cavitation agents investigate and optimize their structureproperties relationships in response to acoustic cavitation this project offers a unique integration of approaches competences and resources in material science synthesis of ccas physics modelling and chemistry activation of small molecules the iterative project focus on the most fundamental understanding of the physical mechanisms will allow for substantial progresses into the complex phenomenon of sonochemistry and sonocatalysis
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6g ainative integrated rancore networks
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this sns international project fosters collaboration between the european union eu and the republic of korea rok ainative radio access networks and integrated devicenetwork approaches represent a paradigm shift in the field of wireless communication offering unprecedented opportunities for innovation and optimization by leveraging artificial intelligence ai technologies at the heart of radio access networks ran and integrating devices seamlessly into network architectures we can unlock new levels of efficiency flexibility and performance traditional approaches to wireless communication are often limited by static configurations and manual interventions leading to suboptimal resource utilization and scalability challenges in contrast ainative ran and integrated devicenetwork approaches empower networks to adapt dynamically to changing conditions optimize resource allocation in realtime and autonomously respond to diverse user demands and environmental factors this transformative approach not only enhances the user experience by delivering higher throughput lower latency and improved reliability but also lays the foundation for realizing a diverse range of innovative services including spatiotemporal critical computeai omnipresent iot immersive communications and global broadband services moreover by fostering interoperability and collaboration between devices and networks these approaches pave the way for seamless connectivity across heterogeneous environments driving innovation and fostering new business models in the era of 6g and beyond the project builds on the foundations of established eukorea research collaboration including 5gchampion project that demonstrated 5g technology in the 2018 winter olympics in pyeongchan primo5g project that demonstrated endtoend 5g system providing immersive video services for moving objects and 5gallstar project that showcased smooth 5g terrestrial and satellite integration
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contentious politics and democratic renewal in sustainability transitions
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trans4demo is an evidencebased and impactdriven set of actions to address contentious politics arising from climate change and sustainable transitions these conflicts are seen as a critical challenge for democratic systems and their importance is expected to grow in the future authoritarian tendencies and rightwing populism have weakened social cohesion making large parts of eu populations less willing to change their practices and hindering responses to climate challengesthe main objective of the project is to investigate the role and evolution of diverse forms of opposition and contentious politics of sustainability transitions and their impact on democracy we aim at delivering the temporalitysensitive conceptual framework practical understandings and policy recommendations to assist in democracy reinvigoration by exploring these intersections we identify specific scientific consensusbased and politically normative goals that political communities in diverse european contexts could pursue empirically throughout the project we will 1 focus on practical understandings of the role of various bottomup mobilizations against the populist backdrop 2 identify novel sites of constructive democratic engagement and 3 address the role of trust in the democratic process including the validity of electoral processes building on this 4 we will provide sound researchbased policy recommendations that balance bottomup and topdown perspectives for democratic renewalto achieve these targets we will employ triangulated and participatory methodologies including case studies and futureoriented methods developed in collaboration with societal actors involved in the projectfrom the initial design of the research agenda to fieldwork and dissemination activities
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uncovering the regulatory landscape of arabidopsis thaliana responses to cold temperatures
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plants as sessile organisms must constantly adapt to variable environmental conditions among which temperature is of paramount importance in the context of climate change indeed in future years despite an expected rise in temperatures due to global warming we can also expect an increase in the frequency of severe cold periods for which plants are not prepared therefore understanding the molecular processes that allow plants to react and adapt to cold is essential for developing coldresistant plants which is ultimately indispensable for global food security in recent decades many studies have embarked in addressing this issue however the global regulatory landscape underlying cold acclimation and adaption of plants to noisy and fluctuating natural cold conditions remain poorly investigated low temperatures are known to have a direct effect on chromatin accessibility which is directly linked to gene expression therefore the aim of this project is to investigate the dynamics of the coding and noncoding arabidopsis thaliana transcriptome as well as changes in chromatin accessible sites in response to regimes of decreasing temperatures to this end a comparative analysis of deepcoverage rnaseq transcriptome and atacseq chromatin accessibility will be performed on a thaliana plants grown over weeks of fluctuating temperatures mimicking natural cold conditions of autumn and early winter the proposed experimental design will reveal novel coding genes long noncoding rnas lncrnas and potential distal regulatory elements involved in arabidopsis responses to cold thus by combining interdisciplinary and mutually reinforcing approaches including epigenomics epigenetics transcriptomics and bioinformatics the proposed project will significantly improve our understanding of the molecular mechanisms required for plant adaptation to cold temperatures likely delivering valuable tools for future breeding of cold resilient crop species
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scientific societies and the globalization of science 19301990
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science has become a global enterprise to produce knowledge scientists with different nationalities gender backgrounds ethnicities and sociopolitical views engage in debate and adopt shared codes of conduct eg leaving out personal bias when evaluating each others work this project conducts historical research into the mechanisms that structure these global social relations within science by using 20th century scientific societies as its lens it hypothesizes that these hitherto unstudied societies have played a regulatory role in the globalization of science by acting as gatekeepers simultaneously opening up and limiting access to subgroups such as women scholars or scholars from the global south by organizing massive conferences selecting speakers allocating prizes electing boards etc building on studies of gender and ethnicity in science and on sociological analyses of evaluation in science global academies innovates the concept of scientific sociability to include unspoken codes of conduct that could establish divisions within scientific groups allowing the study of societies mechanisms of in and exclusion of setting implicit standards and their strategies for coping with political dissent the project innovates methodologically by engaging in multisited research into scientific societies in the usa france india and brazil and at the international level and by using multiple research methods journal analysis archival research and oral history in which presentday scientific societies are involved as stakeholders the project aims 1 to develop a conceptual toolkit for scholars across the humanities and social sciences to understand scientific societies formats standards and customs in relation to scientists group behavior and 2 to set a new historical framework for understanding the role of scientific societies in science foregrounding issues of gender ethnicity and geopolitics in an era of decolonization
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the emotional aspects of resistance and solidarity
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gender and racial discrimination are critical and pervasive problems in academic institutions worldwide apart from being underrepresented in some fields such as stem and philosophy gender and racial minorities are disproportionately vulnerable to sexual and racial harassment in higher education in 2021 a report on universities in the uk determined that women were nearly twoandahalf times as likely to experience sexual violence as men while staff on insecure contracts those with disabilities lgbtq or black asian or minority ethnic were also at greater risk academic institutions have sometimes sought to remedy to these exclusions by implementing diversity policies aimed at increasing the number of underrepresented groups among staff and students however and more problematically even when diversity policies and measures to fight against sexual and other forms of harassment are in place academic institutions tend to be more concerned with protecting the institution from reputational damage than with the safety and wellbeing of the victims reports that document the extent of these harms in universities point out that a change of culture is needed if we do not address the cultural environment that feeds these violent forms of exclusion diversity and antiharassment policies will be insufficient however as long as we do not understand what makes this culture so persistent we will lack the appropriate concepts and tools to change it my contention is that while sexual and racial harassment are among the most harmful and violent manifestations of oppression they are rooted in an ecosystem of cognitive and emotional habits that sediment in exclusionary practices against minorities my research project will be especially concerned with addressing these emotional conditions by asking how oppressed and oppressors need to engage with their emotions in order to resist against oppression and build more cooperative ways of living together
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sarscov2induced activation of pathogenic endogenous retrovirus envelope hervw towards personalized treatment of covid19 patients
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severe covid19 disease and the high frequency of its longterm complications are now a major health problem worldwide due to the significant heterogeneity of covid19 disease profiles biomarkers that allow either the identification of patients at high risk for developing severe forms of covid19 and its longterm complications or guide personalized treatment options are scarce the hervcov project aims to analyze the role of human endogenous retroviruses hervs known for their high proinflammatory potential in the immunopathogenesis of covid19 and to identify and evaluate a set of biomarkers which will be important for the diagnosis prognosis and followup of covid19 patients and their prioritization for targeted therapy recent data from the consortium has demonstrated that hervw envelope protein is highly expressed in lymphocytes of covid19 patients and correlates with inflammatory markers and respiratory outcome of the disease strongly suggesting the role of hervs in covid19 pathogenesis the project aims to assess the biological pathways and functions that underlie the association of herv expression and activation with severe covid19 forms and related complications biomarkers based on herv pathogenic protein activation sarscov2specific immune responses cytokine production and mandatory medical blood analyses for covid19 clinical monitoring will be studied in samples from different forms of covid19 acute post neuro and longcovid patients parameters will be determined that predict the clinical course of the disease and aggravation of sarscov2induced symptoms and allow potential clustering of different bioclinical profiles of covid19 patients diagnostic and prognostic panels translated from our fundamental research and subsequent evaluations of hervassociated biomarkers will be assessed to define novel indicators in precision medicinebased therapeutic strategies leading to individualized medical treatment in covid19
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driving sustainable climate transition of videoondemand platforms at a time of transformation
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the overarching goal of streamscapes is to kick start a new era in forward thinking and doing in the ways in which production consumption and decisionmaking systems in the cultural and creative industries ccis lead through the sustainable climate transition sct with a particular emphasis on videoondemand vod platforms as central nodes within audiovisual and cultural ecosystems specifically streamscapes will provide i an interdisciplinary mapping and assessment of the ways in which it is possible to substantially green the operations of vod platforms in the ccis ii pilot the transformative impact of vod platforms to engage in blue skies generation of ideas through a hubs based approach in the form of a future studies approach with a special focus on children and youth and iii cotest the potential of vod platforms to contribute to the sct in line with the european industrial strategy and the european green deal to achieve this a multistakeholder team of four core academics and eight key stakeholders including several european vod platforms combines original data and knowledge and collated best practices streamscapes among other things a develops robust methods to measure the carbon footprint of vod platforms and a pilot sct vod certification b designs and develops business clinics providing advice on how vod platforms can best green their business models c develops a streamscapes dashboard making public data such as the carbon footprints of vod platforms available to policymakers professionals and citizens d identifies underutilised approaches that can be used by vod platforms to boost the sct e delivers a firstaid kit handbook to empower vod professionals audiovisual and cultural workers and citizens to support the sct in a bottomup manner paying particular attention to engaging young people and children in practices and blue skies imaginations towards innovation
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genetic engineering as an approach to enhance the lipidbinding properties of the flowering locus t the member of the phosphatidylethanolaminebinding protein family
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eu mission for adaptation to climate change perceives the improved dryland agriculture as one of the ways to adapt and survive humans have the technology and processes to address the major agricultural issues today such as pest infestation droughts the misuse of herbicides however the global warming requires a new set of tools and the willingness to adapt from all of us the key developmental switch for the flowerfruit bearing plants is the change from vegetative to reproductive growth and the timing is crucial the climate changes have been already impacting the flowering as several perennial and annual crops have flowered earlier by about 2 days per decade during the last 50 years the flowering locus t is a plant protein highly recognized as a part of the florigen complex a mobile protein that is produced in the leaf companion cells and transported to the plant shoot apex to induce flowering my previous work was focused on the ft preference to bind to phosphatidylglycerol pg over other lipid species in the temperaturedependent manner and the impact on the flowering time the msca project will address the relevance of the wider array of ftpg interactions by utilizing the genetic modifications to produce and characterize the ft mutant proteins with enhanced lipidbinding properties the super sticky ft would be difficult to remove from the membrane which could have a potential industrial application a challenge would be to create the protein that could not bind to the membrane which will shed a new light onto flowering regulation the multidisciplinary approach consisting of molecular biology biochemistry structural chemistry and biophysics will produce deliverables for the subsequent in planta project the measured impact of different ambient temperatures will provide us with the knowledge of the finetuning and control over the proteinlipid interactions which could have the longstanding effects in the agricultural applications
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mechanism and targeting of topoisomerase regulatory interactions to arrest mycdriven tumors
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inhibitors of dna topoisomerases tops top1 top2 are mainstays of anticancer therapy while they have proven effective the toxicity of current top drugs caused by dna damageinduced apoptosis of noncancer cells limits their use in clinic development of tumourspecific top inhibitors will require a better knowledge of the mechanisms of tops this research program aims to define how top are regulated during transcription and replication and develop drugs that target these regulatory mechanisms for anticancer treatmenttops promote transcription and replication by removing dna supercoiling generated during polymerase elongation in my works published in cell and molecular cell i have discovered that the activity of tops in the cell is regulated the oncoprotein myc joins top1 and top2 in a topoisome complex and stimulates their activities to remove the supercoiling produced during transcription and replication thus boosting cellular proliferation therefore i propose that targeting the mechanism of the topoisome instead of the single tops will selectively halt myc oncogenic function while preserving physiological top activity avoiding the generation of dna damage associated to current top drugs by using new genomic tools to analyse dna topology advanced biochemical and microscopy approaches as well as drug screens i will define the mechanism of mycdriven transcriptionalreplicational acceleration via topoisome assembly and develop drugs blocking topoisome activity to arrest tumour growth i predict this proposal is feasible based on my excellent background compelling preliminary data and strong collaborations with scientists at ki and national institutes of health the work will identify novel strategies to target tops that can be put forward in clinical trials for the benefit of society this new way of targeting tops to affect myc activity constitutes a beyond the stateoftheart and groundbreaking approach to the field of cancer biology
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sustainable reactor and microreactor designs for boosting green and digital innovation
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reactor technologies are core to many chemical and biological processes therefore enablers of defossilisation digital empowering and economic growth eg new reactor designs are required for manufacturing of chemicals from solar light and advanced microreactor designs are key to meet needs in personalised medicine the design of reactors and microreactors share fundamental concepts such as mass and heat transfer and reaction kinetics often referred to as first principles the university of minho uminho has built international reputation for innovative fundamental research in biomolecular and cellular processes with multiple researchers ranked in the top 1 of most cited by accessing a range of worldclass analytical microfabrication and supercomputing facilities and deploying machine learning and computational modelling driven by experimental big data sets reactors50 will demonstrate and deliver a number of new sustainable reactor and microreactor concepts in full respect of first principles these technologies will be disseminated and exploited to enable innovative green and digital devices and processes and foster economic growth directly contributing to sustainable development goals and setting eu as a global leader in the development of green and digital reactormicroreactor based innovations the era chair will bring expertise in reaction engineering and an international interdisciplinary network from nonwidening countries to nurture at uminho a transformative research training and technology innovation programme that will boost excellence and attract and mobilise outstanding talents this will advance uminhos longterm ambition of establishing a worldclass centre of excellence and innovations based on moleculartocellulartoreactor nexus driving the development and implementation of transformative tools and devices able to generate global impact in three key areas of intervention of the institution food environment and health
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boltzmann models for polyatomic gases and mixtures analysis macroscopic limits and entropy methods
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bame is a project in applied mathematics tackling problems in kinetic theory of gases we will focus on the system of boltzmannlike equations that describes gas mixtures composed of monatomic and polyatomic gases experience has shown that kinetic models accurately describe strong nonequilibrium processes in gas flows however most of the mathematical theory is limited to the oversimplified case of a single monatomic gas our aim is to contribute in filling this gap between study of more intrigant gases suitable for applications and the current state of the art in mathematical theory of kinetic equations objectives are to study regularizing effects of the boltzmann operator integrability smoothness and strict positivity of solutions with the ultimate goal of encoding large time behavior using entropy methods the project will bring together the researcher with distinguished expertise in modelling and analysis of polyatomic gases and mixtures at the mesoscopic level and the host with groundbreaking work on entropy methods for macroscopic systems the two levels of descriptions will be bridged formally through hydrodynamic limits at the secondment leading to the redesign of entropy production program to the system of interest the fellowship will enable the researcher to gain new analytical skills and greatly improve transferable skills through the reach training offer at the host university of graz moreover it will significantly extend her research network and facilitate participation in leading events in the field leading to the capability to launch her own research group in the future and to enhance the career perspectives in academia
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multidimensional representation enabling an alternative research agenda on the citizenpolitician relationship
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political representation the relationship between politicians and citizens is at the core of democracys legitimacy and functioning most empirical research in political science studies two aspects of representation 1 whether politicians substantive policy preferences match those of the citizenry or 2 whether representatives are like their constituents in terms of descriptive characteristics eg gender or race however recent research in political theory has highlighted additional dimensions of the citizenpolitician relationship eg whether citizens identify with politicians they have not voted for how politicians relate to their party and argued that citizens own views of how they want to be represented should be the starting point for studying representation yet these insight have barely affected how representation is studied in quantitative political science suggesting that we may currently neglect important aspects of representation multirep aims to ascertain whether citizens care about further dimensions of representation and develop the methodological tools to study them thereby fundamentally reshaping the scope and depth of empirical research in the field first it uses indepth citizen interviews and surveyexperimental techniques to determine how people think about representation and which dimensions are most important to them second for the most important dimensions it develops novel quantitative survey and textanalytical tools to measure citizens preferences and politicians behavior third it advances and operationalizes normative standards to assess the quality of representation on these dimensions on the basis of empirical data thereby multirep will enable an alternative research agenda on the citizenpolitician relationship that takes a broader perspective given citizens declining trust in democratic politics we cannot afford to maintain an incomplete picture of what it means for citizens to feel represented
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hybrid electric regional aircraft distribution technologies
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aviation needs to meet the ambitious targets of the european green deal this means a step change is needed towards hybrid electric regional aircraft to significantly reduce the fuel burn this can only be accomplished with power distribution networks that can safely handle the high power and high voltage levels ultimately up to several megawatt the hecate project will address the associated challenges of system weight and power density high voltage challenges with lightning arcing and electromagnetic interference as well as optimized thermal management in addition to digitizing the design process with digital twins this will lead to transformative technology bricks which are holistically optimized at system integration architecture level the hecate project will demonstrate a 500 kw architecture in a copper bird at trl5 this will provide a clearer understanding of high voltage challenges and how to mitigate them with a scalability roadmap towards caju phase 2 flight demonstration and exploitation in a 2035 new built hybrid electric regional aircraft also environmental impact and lca will be assessed for optimal alignment and ensuring certifiability hecate will establish relationships with other clean aviation projects eg her01 for mw propulsion her02 for thermal tra01 for architecture tra02 for certification and authorities and standards groups eg easa eurocae as a set of key enabling technologies that are well integrated hecate will contribute to the clean aviation sria and its expected impacts and fully fulfill the calls expected outcomes the 37member consortium mobilizes key eu based industries throughout the entire existing supply chain from aircraft oems to system integrators to system and subsystems suppliers 5 of which are smes 17 rtos complement and reinforce the industries which also ensures knowledge gained is embedded in future research and education programs hecate requests 34 210 348 of grant
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deciphering the roles of reactive oxygen species and calcium during viral infection in arabidopsis
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as sessile organisms plants always have to deal with different environmental stimuli the generation of reactive oxygen species ros and calcium flux as second messengers are one of the common strategies to respond to such stimuli upon perception of pathogens molecular warning signals ros and calcium propagate celltocell to trigger defence mechanisms however the precise roles of ros and calcium during viral infection process and the associated signalling mechanism remain largely unknown viruses are obligate intracellular pathogens that hijack host machineries to facilitate their replication and propagation across the plant through plasmodesmata communication channels bridging the plant cells the virosca projects goal is to explore the mutual role of generated ros and calcium signals and to study the crosstalk between the two signals during viral infection and later identify the virus elements that specifically induces such signals i will integrate arabidopsis genetics biosensors genome editing technology crisprcas9 and advanced microscopy techniques to decipher the roles of plasma membrane pmlocated ros and calcium related candidate proteins and pm organisation nanodomains during the plant virus infection process the novelty of the project is the use of a powerful pathosystem and biosensors to study the crosstalk between ros and calcium signalling
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beyond the chromosome unravelling the interplay between interchromosomal genome architecture and mrna biogenesis
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in trans3 we will develop the theoretical and experimental framework to understand interchromosomal genome structure and activity despite advances in sequencing chromosomes and mapping their three dimensional 3d organization a full picture of 3d genome structure that details how the borders of various chromosome territories functionally interface one another is still missing as an analogy our world map does not indicate most natural corridors or manmade infrastructure that connect countries to one another worse we barely understand how such connections function my recent work has identified one of the few functional interchromosomal trans dna interactions known to date a splicing factory involving over ten chromosomes and orchestrated by the musclespecific protein rbm20 around its key target the ttn premrna i hypothesize that this exemplifies how mrna biogenesis instructs the formation of transinteracting chromatin domains tids around mrna factories nuclear compartments that facilitate gene regulation we will test this general hypothesis by dissecting the mechanisms and function of a specific diseaserelevant model the rbm20 mrna splicing factory we will then explore the global impact of these regulations first wp1 we will mechanistically assess how mrna factories form and act through live imaging of the nuclear positioning and alternative splicing dynamics of an rbm20regulated locus secondly wp2 we will examine the physiological role of mrna factories by studying the effects of diseaseassociated mutations in rbm20 and the ttn regulator gata4 and of genetic variability in ttn regulatory regions finally wp3 we will develop and deploy a novel pipeline to identify validate and study new tids and mrna factories through the combination of molecular biology bioinformatics biochemistry and single cell biology in all trans3 will venture beyond the chromosome frontier towards a deeper understanding of nuclear structurefunction
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improving cellular cancer immunotherapy using chemotactic metabolite receptors
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chimeric antigen receptor t cell car t cellular immunotherapy has revolutionized treatment for patients with hematological cancers but largely failed to provide benefits for patients with solid tumors ineffective car t migration into solid tumors caused by the lack of recruitment signals including chemokines is a key gap for current cellular immunotherapies the very common accumulation of metabolites in tumors provides a yet unrecognized opportunity to guide immune cells into tumors therefore my overall research objective for this project is to generate and use novel chemotactic metabolite receptors metabotract to enhance the efficacy of car t and natural killer nk in solid tumors this innovative approach is expected to impact the therapeutic options for cancer patients with poorly infiltrated tumors and enhance the eus competitiveness in the rapidly expanding market of cellular immunotherapies applying the gained knowledge on car nk cells could additionally reduce treatment costs and accelerate deployment of cellular therapies to patients during the msca fellowship i will learn vital new skills including cell migration assays in vivo models for immunotherapies project management exploitation and leadership in the renowned laboratory of prof sebastian kobold at the ludwigmaximiliansuniversity lmu in munich the expertise of prof kobolds lab with chemokine receptor car t cells and in vivo models together with my complementary skills in cellular immunology nk cells imaging and bioinformatics gives the project a high likelihood of success the publication of the results the gained knowledge and skills and the demonstrated mobility will strengthen my scientific independence and help me achieve my career goal of becoming a research group leader in cellular cancer immunotherapy
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