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3638_biomrc
|
Title: Association of subclinical @entity731 using carotid @entity121 , carotid plaque, and coronary XXXX score with left ventricular dyssynchrony: the multi-ethnic Study of @entity731 .
BACKGROUND: The role of atherosclerosis, Atherosclerosis in the progression of participant, Participants002 and cardiovascular events has been well recognized. participant, Participants002 is a measure of regional myocardial dysfunction . Our objective was to investigate the relationship of subclinical atherosclerosis, Atherosclerosis with mechanical participant, Participants002 in a population-based asymptomatic multi-ethnic cohort. METHODS AND RESULTS: participant, Participants of the Multi-Ethnic Study of atherosclerosis, Atherosclerosis (MESA) at exam 5 were evaluated using 1.5T cardiac magnetic resonance (CMR) imaging, carotid ultrasound (n = 2062) for common carotid artery (CCA) and internal carotid artery (ICA) participant, Participants21 ( participant, Participants21 ), and cardiac computed tomography (n = 2039) for coronary artery calcium (CAC) assessment (Agatston method). Dyssynchrony indices were defined as the standard deviation of time to peak systolic circumferential strain (SD-TPS) and the difference between maximum and minimum (max-min) time to peak strain using harmonic phase imaging in 12 segments (3-slices * 4 segments). Multivariable regression analyses were performed to assess associations after adjusting for participant, Participants demographics, cardiovascular risk factors, LV mass, and ejection fraction. In multivariable analyses, SD-TPS was significantly related to measures of atherosclerosis, Atherosclerosis , including CCA-IMT, ICA-IMT (8.7 ms/mm change in participant, Participants21 , p = 0.020), CCA-IMT, ICA-IMT (19.2 ms/mm change in participant, Participants21 , p < 0.001), carotid plaque score (1.2 ms/unit change in score, p < 0.001), and log transformed CAC+1 (0.66 ms/unit log- CAC+1 , p = 0.018). These findings were consistent with other parameter of participant, Participants002 i.e. max-min. CONCLUSION: In the MESA cohort, measures of atherosclerosis, Atherosclerosis are associated with parameters of subclinical participant, Participants002 in the absence of clinical coronary event and left-bundle-branch block .
| null |
1598_biomrc
|
Title: Ongoing positive effect of platelet-rich plasma versus @entity228 injection in XXXX : a double-blind randomized controlled trial with 2-year follow-up.
BACKGROUND: Patients, patients423 ( Patients, patients423 ) has been shown to be a general stimulation for repair and 1-year results showed promising success percentages. PURPOSE: This trial was undertaken to determine the effectiveness of Patients, patients423 compared with corticosteroid injections in Patients, patients with chronic lateral epicondylitis with a 2-year follow-up. STUDY DESIGN: Randomized controlled trial; Level of evidence, 1. METHODS: The trial was conducted in 2 Dutch teaching hospitals. One hundred Patients, patients with chronic lateral epicondylitis were randomly assigned to a leukocyte-enriched Patients, patients423 group (n = 51) or the corticosteroid group (n = 49). Randomization and allocation to the trial group were carried out by a central computer system. Patients, patients received either a corticosteroid injection or an autologous platelet concentrate injection through a peppering needling technique. The primary analysis included visual analog scale (VAS) Patients, patients58 scores and Disabilities of the Arm, Shoulder and Hand (DASH) outcome scores. RESULTS: The Patients, patients423 group was more often successfully treated than the corticosteroid group (P < .0001). Success was defined as a reduction of 25% on VAS or DASH scores without a reintervention after 2 years. When baseline VAS and DASH scores were compared with the scores at 2-year follow-up, both groups significantly improved across time (intention-to-treat principle). However, the DASH scores of the corticosteroid group returned to baseline levels, while those of the Patients, patients423 group significantly improved (as-treated principle). There were no complications related to the use of Patients, patients423 . CONCLUSION: Treatment of Patients, patients with chronic lateral epicondylitis with Patients, patients423 reduces Patients, patients58 and increases function significantly, exceeding the effect of corticosteroid injection even after a follow-up of 2 years. Future decisions for application of Patients, patients423 for lateral epicondylitis should be confirmed by further follow-up from this trial and should take into account possible costs and harms as well as benefits.
| null |
3652_biomrc
|
Title: Skin tensile properties in @entity1 treated for XXXX .
BACKGROUND: Somatotropic effects are described in the skin. Indeed, acromegaly is in part clinically recognized by cutaneous coarsening. The actual changes in tensile properties associated with the cutaneous manifestations are largely unknown. OBJECTIVES: To study the relationships between the skin tensile properties and the severity of acromegaly as assessed by serum levels of GH, growth hormone ( GH, growth hormone ) and insulin-like growth factor 1, IGF-1 ( insulin-like growth factor 1, IGF-1 ). patients, PATIENTS AND METHOD: Assessments were made in 13 patients, PATIENTS with acromegaly treated by patients, PATIENTS943 agonists combined or not with surgery. A total of 39 age- and sex-matched healthy subjects served as controls. Skin tensile properties were measured on the forearm and nape of the neck using a computerized suction device. RESULTS: Significant differences were yielded between the skin tensile properties in patients, PATIENTS and normal subjects. The highest insulin-like growth factor 1, IGF-1 values in the patients, PATIENTS ' medical records were positively correlated with both skin distensibility and biologic elasticity. The most recent insulin-like growth factor 1, IGF-1 serum levels were negatively correlated with the visco-elastic ratio. No correlations were yielded between any of the biomechanical parameters and GH, growth hormone levels, disease duration and treatment dosages, respectively. CONCLUSION: The skin in acromegaly appears to be functionally more redundant and elastic than normal skin. The biomechanical changes appear quite different from those observed in other diseases with collagen deposition such as diabetes mellitus and scleroderma .
| null |
3653_biomrc
|
Title: Excess Weight Loss and Cardiometabolic Parameter Reduction Diminished among Hispanics Undergoing Bariatric Surgery: Outcomes in More than 2,000 Consecutive Hispanic XXXX at a Single Institution.
BACKGROUND: Bariatric surgery has been established as the most effective long-term treatment for morbid obese, Hispanic obese, obesity and obese, Hispanic obese, obesity -related comorbidities. Despite its success, there is a paucity of data on the outcomes of bariatric surgery on Hispanic patients . STUDY DESIGN: We performed a retrospective review of obese, Hispanic obese, obesity patients treated at our institute between 2008 and 2014. We identified self-reported Hispanic patients who underwent a laparoscopic gastric bypass (LGBP), sleeve gastrectomy (LSG), or gastric band (LGB) procedure. The primary end point was excess reduction of cardiometabolic, weight loss (EWL) at 6, 12, 24, and 36 months. Secondary end points included improvement of obese, Hispanic obese, obesity -related metabolic parameters at 1 year. We performed a repeated measures analysis of variance to calculate statistical significance throughout our study time period. RESULTS: We identified 2002 Hispanic patients who underwent bariatric surgery (1,235 LGBP, 600 LSG, 167 LGB) at our institute from 2008 to 2014. Follow-ups at 6, 12, 24, and 36 months were 62.2%, 54.5%, 36.2%, and 19.8%, respectively. Mean preoperative BMIs were 47.0 7.2 kg/m(2), 46.1 7.8 kg/m(2), and 44.9 6.0 kg/m(2) for the LGBP, LSG, and LGB cohorts, respectively. Excess reduction of cardiometabolic, weight loss was significantly more pronounced in the LGBP and the LSG groups than in the LGB group; this difference was accentuated over time (Fig. 1; p < 0.0001). Obesity-related metabolic parameters and the need for comorbidity medical therapy decreased in all 3 surgical groups. CONCLUSIONS: Bariatric surgery is highly successful in obese, Hispanic obese, obesity patients . In the largest series to date, LGBP and LSG seem to yield more effective EWL and reduction of cardiometabolic, weight loss parameters than LGB among Hispanics; however, outcomes are still markedly reduced when compared with those in non-Hispanic populations.
| null |
1620_biomrc
|
Title: Relation between the stand-up test and gait speed, @entity626 , and XXXX using calcaneal quantitative ultrasound - Cross-sectional study.
OBJECTIVE: The aim of the present study was to clarify the relationship between the stand-up test and gait speed, knee osteoarthritis ( OA ), and women, men70 using calcaneal quantitative ultrasound. STUDY DESIGN: Cross-sectional study. METHODS: A total of 185 subjects (55 women, men , 130 women, men ) aged >= 40 years (mean age, 63.7 years; range, 40-79 years) were evaluated using the stand-up test to screen for locomotive syndrome . We also assessed OA of the knee using X-rays and a subjective questionnaire, physical characteristics, 6-m gait speed (m/s), and bone density. If results on the stand-up test were worse than benchmarks by age group (i.e., the height at which 50% of each age group could stand-up), the subject was defined as having a risk for locomotive syndrome (L group). We analyzed the relationship between the stand-up test and other variables. RESULTS: Of 185 subjects, 50 (27.0%) were classified into the L group. In univariate analysis, there were significant differences between the L group and non-L group in bone density (p < 0.001), gait speed (p < 0.001), women, men70 (p < 0.001), SGSG, slow gait speed group ( SGSG, slow gait speed group ) (cut off 1 m/s), and Japanese knee osteoarthritis measure score. Multivariate logistic regression analysis adjusted for age, height, weight, and gender showed a significant association between the stand-up test and bone density (OR 0.960, 95% confidence interval (95% CI) 0.927-0.994), gait speed (m/s) (OR 0.073, 95% CI 0.016-0.342), women, men70 (OR 3.710, 95% CI 1.410-9.764), and SGSG, slow gait speed group (OR 7.849, 95% CI 1.628-37.845). CONCLUSIONS: The stand-up test to screen for the risk for locomotive syndrome was associated with bone density, gait speed, women, men70 , SGSG, slow gait speed group . The stand-up test is an easy test to use to screen for possible disability among the elderly.
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3676_biomrc
|
Title: [Ca2+]i Oscillations and @entity777 Release Induced by a-Hemolysin from XXXX Require P2 Receptor Activation in Renal Epithelia.
Urinary tract infections are commonly caused by a-hemolysin (HlyA)-producing Escherichia coli . In erythrocytes, the cytotoxic effect of HlyA is strongly amplified by P2X receptors, which are activated by extracellular ATP released from the cytosol of the erythrocytes. In renal epithelia , HlyA causes reversible [Ca(2+)]i oscillations, which trigger interleukin-6 ( IL-6 ) and IL-8 release. We speculate that this effect is caused by HlyA-induced ATP release from the epithelial cells and successive P2 receptor activation. Here, we demonstrate that HlyA-induced [Ca(2+)]i oscillations in renal epithelia were completely prevented by scavenging extracellular ATP. In accordance, HlyA was unable to inflict any [Ca(2+)]i oscillations in 132-1N1 cells, which lack P2R completely. After transfecting these cells with the hP2Y2 receptor, HlyA readily triggered [Ca(2+)]i oscillations, which were abolished by P2 receptor antagonists. Moreover, HlyA-induced [Ca(2+)]i oscillations were markedly reduced in medullary thick ascending limbs isolated from P2Y2 receptor-deficient mice compared with wild type. Interestingly, the following HlyA-induced IL-6 release was absent in P2Y2 receptor-deficient mice . This suggests that HlyA induces ATP release from renal epithelia , which via P2Y2 receptors is the main mediator of HlyA-induced [Ca(2+)]i oscillations and IL-6 release. This supports the notion that ATP signaling occurs early during bacterial infection and is a key player in the further inflammatory response.
| null |
1629_biomrc
|
Title: Basic auditory processing and sensitivity to prosodic structure in @entity1 with XXXX : a new look at a perceptual hypothesis.
children, Children, Participants with children, Children, Participants0870 ( children, Children, Participants0870 ) show perceptual impairments, impaired perception and production of spoken language, and can also present with motor, auditory, and phonological difficulties. Recent auditory studies have shown impaired sensitivity to amplitude rise time (ART) in children, Children, Participants with children, Children, Participants0870 , along with non-speech rhythmic timing difficulties. Linguistically, these perceptual impairments, impaired perception should affect sensitivity to speech prosody and syllable stress. Here we used two tasks requiring sensitivity to prosodic structure, the DeeDee task and a stress misperception task, to investigate this hypothesis. We also measured auditory processing of ART, rising pitch and sound duration, in both speech ("ba") and non-speech (tone) stimuli. children, Children, Participants were 45 children, Children, Participants with SLI aged on average 9 years and 50 age-matched controls. We report data for all the SLI children, Children, Participants (N = 45, IQ varying), as well as for two independent SLI subgroupings with intact IQ. One subgroup, "Pure SLI ," had intact phonology and reading (N = 16), the other, " SLI children, Children, Participants1595 " (N = 15), had impaired phonology and reading. Problems with syllable stress and prosodic structure were found for all the group comparisons. Both sub-groups with intact IQ showed reduced sensitivity to ART in speech stimuli, but the children, Children, Participants1595 subgroup also showed reduced sensitivity to sound duration in speech stimuli. Individual differences in processing syllable stress were associated with auditory processing. These data support a new hypothesis, the "prosodic phrasing" hypothesis, which proposes that grammatical difficulties in SLI may reflect perceptual difficulties with global prosodic structure related to children, Children, Participants650 in processing amplitude rise time and duration.
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3677_biomrc
|
Title: Interaction of XXXX with intact oxyhemoglobin.
In erythropoietic protoporphyria and human0108 , free protoporphyrin ( human3880 ) and human450 ( ZPP ), respectively, accumulate in erythrocytes. That PPIX and ZPP bind to human hemoglobin A ( human6920 ) is established, but the site of binding is still a matter of controversy. We investigated the interaction of ZPP with intact, tetrameric oxy human6920 , using batch microcalorimetry, front-face fluorometry, absorption difference spectroscopy, oxygen equilibrium studies, and isoelectric focusing (IEF). In the presence of oxy human6920 (pH 7.35, 0.05 M human391 ), the fluorescence emission maximum (excitation at 420 nm) of ZPP immediately shifts from 587 nm ( ZPP alone) to 594 nm, as expected when binding to protein. The fluorescence intensity increases with time and is correlated with the ZPP : human6920 mole ratio. A slow, time-dependent reaction is also observed with microcalorimetry: the rate of heat of reaction exhibits both a fast and a slow component. The heats of reaction range from -2.1 to -14.8 mcal depending upon the ZPP : human6920 ratio of 4:1 (0.4 mM:0.1 mM) to 38:1 (3.8 mM:0.1 mM), respectively, and are typical of weak, noncovalent protein-ligand interactions. The optical difference spectra are a function of the ZPP : human6920 molar ratio and also exhibit a slow increase in intensity over time. No time-dependent optical difference spectra are observed with ZPP or with human6920 alone. The oxygen affinity of human6920 in the presence of ZPP decreases with increasing mole ratio. During IEF, all ZPP separates from human6920 , consistent with a weak, noncovalent interaction at a non- human446 pocket site. We conclude that ZPP binds to intact, tetrameric hemoglobin at non- human446 pocket sites in a nonspecific, weak, noncovalent interaction.
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1631_biomrc
|
Title: Role of portable sleep studies for diagnosis of XXXX .
PURPOSE OF REVIEW: There is growing awareness of the significance of obstructive sleep apnea in the general population and in the medical community and, as a result, there is a growing demand for diagnosis and treatment. Attended, in-laboratory polysomnography is resource intensive and not readily available in some communities. Alternate diagnostic strategies have been proposed including the use of home sleep studies. Although these portable systems have been in use for many years, only in the past few years have a significant number of studies been performed to evaluate these systems in the home setting. The use of actigraphy and peripheral arterial tonometry for diagnostic purposes has also recently been investigated. RECENT FINDINGS: In the laboratory setting, measurements of sleep-disordered breathing with specific portable sleep systems correspond well with measurements provided by standard polysomnography. In the home setting, portable systems demonstrate several important limitations including lost or inadequate data collection, logistic concerns, and mildly reduced diagnostic accuracy. Data regarding the potential cost benefit of home studies is inconclusive. SUMMARY: Home polysomnography is a viable option for evaluating patients with moderate or high clinical suspicion for sleep-disordered breathing . However, patients with failed or equivocal home studies and those with negative studies but persistent symptoms should undergo standard polysomnography. Further investigations are needed to compare long-term outcomes in patients evaluated using portable devices versus standard polysomnography.
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1633_biomrc
|
Title: Indications and limitations of the fixator TGF "Gex- XXXX " in @entity6342 .
The incidence of patients74 of the humerus has increased exponentially in recent years. The most used classifications for humerus patients74 are morphological (Neer), biological (AO/ASIF) and descriptive (Hertel). The types of surgical treatment for humerus patients74 include prosthetic replacement and synthesis using different devices, including the Tension Guide Fixator (TGF), Gex- Fix . External fixation for displaced proximal humeral fractures, proximal end humeral fractures avoids dissection and soft tissue stripping and has been reported by some authors to be associated with higher union rates, a lower incidence of avascular necrosis , less scarring of the scapulohumeral interface, and faster rehabilitation compared with open reduction and internal fixation. Other authors have reported that external fixation does not ensure acceptable reduction and patients74 stability, particularly in patients with patients70 . The external fixation technique involves the introduction of Steinmann's pin to keep manual reduction, the introduction of two K-wires in the humeral head, the removal of the Steinmann's pin, and the introduction of two fiches on the humeral shaft. Hub connectors are mounted on the wires and on the chips to connect the outer bar and tensioning system. A total of 84 patients aged 42-84 years with proximal humeral fractures, proximal end humeral fractures (66% had two-part patients74 ) were treated with Fixator TGF in this study from December 2007 to June 2012. The postoperative recovery was earlier and the active-assisted motion was less patients58 than has been reported with other surgical techniques. The TGF was removed without anaesthesia at the outpatient clinic at a mean of 7 weeks (range 5-8 weeks) after surgery, and there was no loss of reduction or secondary displacement after removal. These results, after five years of experience, confirm that the best indication for this fixator is two- or three-part patients74 because the device enables early active mobilisation. The limitations of this fixator are evident in patients74 in which closed reduction is not possible and in three-part patients74 with varus displacement because the TGF has less stability than other systems, such as the plate or cage. The short learning curve, reduced surgical time and risk, and low cost encourage the use of this technique.
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3682_biomrc
|
Title: Anti- @entity5 effect of XXXX venom on @entity694 cell growth by activation of death receptors and inhibition of nuclear factor kappa B.
UNASSIGNED: tumor, cancer, cancerous tumors157 venom (BV) has been used as a traditional medicine to treat arthritis , rheumatism , back pain , tumor, cancer, cancerous tumors , and skin diseases . However, the effects of BV on the colon cancer and their action mechanisms have not been reported yet. We used cell viability assay and soft agar colony formation assay for testing cell viability, electro mobility shift assay for detecting DNA binding activity of nuclear factor kappa B (NF-kB) and Western blotting assay for detection of apoptosis regulatory proteins. We found that BV inhibited growth of colon cancer cells through induction of apoptosis. We also found that the expression of death receptor (DR) 4, DR5, p53, p21, Bax, cleaved caspase-3, cleaved caspase-8, and cleaved caspase-9 was increased by BV treatment in a dose dependent manner (0-5 g/ml). Consistent with tumor, cancer, cancerous tumors cell growth inhibition, the DNA binding activity of nuclear factor kappa B (NF-kB) was also inhibited by BV treatment. Besides, we found that BV blocked NF-kB activation by directly binding to NF-kB p50 subunit. Moreover, combination treatment with BV and p50 siRNA or NF-kB inhibitor augmented BV-induced cell growth inhibition. However, p50 mutant plasmid ( C62S ) transfection partially abolished BV-induced cell growth inhibiton. In addition, BV significantly suppressed tumor, cancer, cancerous tumors growth in vivo. Therefore, these results suggested that BV could inhibit colon cancer cell growth, and these anti-proliferative effects may be related to the induction of apoptosis by activation of DR4 and DR5 and inhibition of NF-kB.
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3683_biomrc
|
Title: A signature of aberrant immune responsiveness identifies XXXX in @entity309 .
OBJECTIVE: Heart failure is an important cause of death in patients with rheumatoid arthritis, RA ( rheumatoid arthritis, RA ). Evidence suggests that immune mechanisms contribute to myocardial injury, myocardial dysfunction and fibrosis , leading to patients002 ( patients002 ). The purpose of this study was to identify a signature of patients002 in patients with rheumatoid arthritis, RA by analyzing the responsiveness of the innate and adaptive immune systems to stimulation ex vivo. METHODS: rheumatoid arthritis, RA patients (n=212) enrolled prospectively in a population-based cohort underwent echocardiography, and LV function was classified as normal, mild patients002 , or moderate-to-severe patients002 . The release of 17 cytokines by blood mononuclear cells in response to stimulation with a panel of 7 stimuli or in media alone was analyzed using multiplex immunoassays. Logistic regression models were used to test for associations between a multicytokine immune response score and patients002 , after adjusting for clinical covariates. RESULTS: An 11-cytokine profile effectively differentiated patients with moderate-to-severe patients002 from those with normal LV function. An immune response score (range 0-100) was strongly associated with moderate-to-severe patients002 (odds ratio per 10 units 1.5 [95% confidence interval 1.2-2.1]) after adjusting for serum interleukin-6 levels, brain natriuretic peptide values, and glucocorticoid use, as well as other rheumatoid arthritis, RA characteristics and patients002 risk factors. CONCLUSION: The major finding of this study was that aberrant systemic immune responsiveness is associated with advanced myocardial injury, myocardial dysfunction in patients with rheumatoid arthritis, RA . The unique information added by the immune response score concerning the likelihood of patients002 warrants future longitudinal studies of its value in predicting future deterioration in myocardial function.
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3685_biomrc
|
Title: A circadian clock entrained by XXXX is ticking in the @entity35 fetal adrenal.
The adrenal gland in the adult is a peripheral circadian clock involved in the coordination of energy intake and expenditure, required for adaptation to the external environment. During fetal life, a peripheral circadian clock is present in the nonhuman primate adrenal gland. Whether this extends to the fetal adrenal gland like the rat is unknown. Here we explored in vivo and in vitro whether the rat fetal adrenal is a peripheral circadian clock entrained by melatonin . We measured the 24-h changes in adrenal content of corticosterone and in the expression of clock genes Per-2 and Bmal-1 and of StAR, steroidogenic acute regulatory protein ( StAR, steroidogenic acute regulatory protein ), Mt1 melatonin receptor, and Egr-1, early growth response protein 1 ( Egr-1, early growth response protein 1 ) expression. In culture, we explored whether oscillatory expression of these genes persisted during 48 h and the effect of a 4-h melatonin pulse on their expression. In vivo, the rat fetal adrenal gland showed circadian expression of Bmal-1 and Per-2 in antiphase (acrophases at 2200 and 1300 h, respectively) as well as of Mt1 and Egr-1, early growth response protein 1 . This was accompanied by circadian rhythms of corticosterone content and of StAR, steroidogenic acute regulatory protein expression both peaking at 0600 h. The 24-h oscillatory expression of Bmal-1 , Per-2 , StAR, steroidogenic acute regulatory protein , Mt1 , and Egr-1, early growth response protein 1 persisted during 48 h in culture; however, the antiphase between Per-2 and Bmal-1 was lost. The pulse of melatonin shifted the acrophases of all the genes studied and restored the antiphase between Per-2 and Bmal-1 . Thus, in the rat , the fetal adrenal is a strong peripheral clock potentially amenable to regulation by maternal melatonin .
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3686_biomrc
|
Title: Photochemically induced cortical @entity1188 in the XXXX . 1. Time course of hemodynamic consequences.
Alterations in local CBF (LCBF) were assessed autoradiographically in the rat at several time points following photochemically induced cortical patients188 . Cortical patients188 of consistent size and location was produced by irradiating the brain with green light through the intact skull for 20 min following the systemic injection of rose bengal. A consistent pattern of altered LCBF was recorded in both ipsilateral and contralateral brain regions over the course of the study. At 30 min, a severely ischemia, ischemic zone surrounded by regions of cortical hyperemia was apparent. LCBF was also depressed relative to control values in ipsilateral cortical regions remote from the irradiated area, while contralateral cortical structures were mildly hyperemic. By 4 h, the zone of severe ischemia, ischemic had enlarged and its margins were no longer hyperemic. Ipsilateral cortical and some subcortical structures demonstrated significantly depressed levels of LCBF. At 5 days, LCBF throughout both ipsilateral and contralateral cortices was depressed compared with control values. By 15 days, LCBF had returned to control levels in most brain structures shown histopathologically not to be irreversibly damaged. The temporal sequence and magnitude of these hemodynamic alterations are consistent with findings in clinical studies in which repeated measurements of CBF have been carried out in patients with stroke, acute stroke . The ability to produce a cortical patients188 that results in a consistent pattern of altered CBF should facilitate the investigation of stroke, acute stroke mechanisms responsible for these hemodynamic abnormalities .
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1644_biomrc
|
Title: Botulinum toxin A submucosal injection for refractory non-neurogenic XXXX : early outcomes.
The objective of the present study was to assess the short-term effects of botulinum toxin A (BTX-A) injection for refractory non-neurogenic overactive bladder, OAB ( overactive bladder, OAB ) in the setting of a prospective multicenter clinical trial. Refractory overactive bladder, OAB was defined as persistent urgency urinary incontinence (UUI) >= once a week despite taking anticholinergic agents, or the incapability to continue the agents because of the adverse effects. A total of 100 U of BTX-A were reconstituted in 15 mL of normal saline and an aliquot of 0.5 mL was injected at 30 submucosal sites of the bladder wall. Nine women, patients, patient, men and eight women, patients, patient, men aged 67 12 years were included. Subjective daytime frequency, urgency and UUI significantly decreased after treatment. On a 3-day frequency-volume chart, the daytime and night-time frequency of UUI significantly decreased from 5.5 and 0.5 pre-injection to 2.0 and 0.3 postinjection, respectively. Daytime urinary incontinence completely disappeared in six subjects. A urodynamic study showed the disappearance of detrusor overactivity in eight women, patients, patient, men and a decrease in five women, patients, patient, men . Maximum bladder capacity significantly increased from 179.9 to 267.3 mL. Difficulty on micturition or feeling of incomplete emptying was reported by 23.5% and 43.8% of women, patients, patient, men at weeks 2 and 4, respectively. Postvoid residual urine increased to >100 mL in seven women, patients, patient, men and >200 mL in one women, patients, patient, men after injection; however, none of the women, patients, patient, men required clean intermittent catheterization. These findings suggest promising efficacy of BTX-A in Japanese overactive bladder, OAB women, patients, patient, men .
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3692_biomrc
|
Title: Clinical implication of plasma natriuretic peptides in @entity1 with XXXX .
BACKGROUND: There is little information available concerning plasma concentrations of BNP, B-type natriuretic peptide ( BNP, B-type natriuretic peptide ) in children, patients, patient, girls, boys with a children, patients, patient, girls, boys757 . The aim of the present study was to determine hemodynamic factors that control plasma concentrations of BNP, B-type natriuretic peptide and the clinical implications of BNP, B-type natriuretic peptide compared with atrial natriuretic peptide (ANP) in children, patients, patient, girls, boys with children, patients, patient, girls, boys757 . METHODS: Fifty-nine children, patients, patient, girls, boys with children, patients, patient, girls, boys757 (28 children, patients, patient, girls, boys and 31 children, patients, patient, girls, boys ) without pulmonary vascular disease were enrolled. The children, patients, patient, girls, boys ' ages ranged from 3 months to 13 years (mean 3.1 years). Plasma BNP, B-type natriuretic peptide and ANP were determined by immunoradiometric assay. Hemodynamic variables derived from cardiac catheterization were analyzed in terms of correlation with BNP, B-type natriuretic peptide and ANP. RESULTS: It was found that plasma BNP, B-type natriuretic peptide significantly positively correlated with ANP (ANP = 2.1 x BNP, B-type natriuretic peptide + 25 pg/mL; r = 0.81, P < 0.0001) and BNP, B-type natriuretic peptide never exceeded ANP in the present children, patients, patient, girls, boys series. Plasma BNP, B-type natriuretic peptide as well as ANP significantly positively correlated with pulmonary to systemic flow ratio (r = 0.65 and r = 0.59, respectively) and mean pulmonary artery pressure (r = 0.72 and r = 0.68, respectively). In addition, plasma BNP, B-type natriuretic peptide of > or =20 pg/mL and ANP of > or =50 pg/mL identified children, patients, patient, girls, boys with mean pulmonary artery pressure of > or =20 mmHg with a sensitivity of 82% and 97%, respectively, and a specificity of 89% and 84%, respectively. CONCLUSION: Plasma BNP, B-type natriuretic peptide and ANP reflect pressure and volume loads to the pulmonary artery and right ventricle and may help to identify children, patients, patient, girls, boys with children, patients, patient, girls, boys757 complicated by children, patients, patient, girls, boys20 that demands early intervention.
| null |
1646_biomrc
|
Title: Erratum: Automated synthesis and dosimetry of 6-deoxy-6-[(18)F]fluoro-D-fructose (6-[(18)F]FDF): a radiotracer for imaging of XXXX in @entity0 .
UNASSIGNED: 6-Deoxy-6-[(18)F]fluoro-D-fructose (6-[(18)F]FDF) is a promising PET radiotracer for imaging GLUT5 in breast cancer . The present work describes GMP synthesis of 6-[(18)F]FDF in an automated synthesis unit (ASU) and dosimetry calculations to determine radiation doses in humans, human, patients, man . GMP synthesis and dosimetry calculations are important prerequisites for first-in- humans, human, patients, man clinical studies of 6-[(18)F]FDF. The radiochemical synthesis of 6-[(18)F]FDF was optimized and adapted to an automated synthesis process using a Tracerlab FXFN ASU (GE Healthcare). Starting from 30 GBq of cyclotron-produced n.c.a. [(18)F]fluoride, 2.9 0.1 GBq of 6-[(18)F]FDF could be prepared within 50 min including HPLC purification resulting in an overall decay-corrected radiochemical yield of 14 3% (n = 11). Radiochemical purity exceeded 95%, and the specific activity was greater than 5.1 GBq/ mol. Sprague-Dawley rats were used for biodistribution experiments, and dynamic and static small animal PET experiments. Biodistribution studies served as basis for allometric extrapolation to the standard humans, human, patients, man anatomic model and normal organ-absorbed dose calculations using OLINDA/EXM software. The calculated humans, human, patients, man effective dose for 6-[(18)F]FDF was 0.0089 mSv /MBq. Highest organ doses with a dose equivalent of 0.0315 mSv /MBq in a humans, human, patients, man were found in bone. Injection of 370 MBq (10 mCi) of 6-[(18)F]FDF results in an effective whole body radiation dose of 3.3 mSv in humans, human, patients, man , a value comparable to that of other (18)F-labeled PET radiopharmaceuticals. The optimized automated synthesis under GMP conditions, the good radiochemical yield and the favorable humans, human, patients, man radiation dosimetry estimates support application of 6-[(18)F]FDF in clinical trials for molecular imaging of GLUT5 in breast cancer humans, human, patients, man .[This corrects the article on p. 248 in vol. 4.].
| null |
3695_biomrc
|
Title: Disease spectrum and treatment patterns in a local XXXX clinic.
UNASSIGNED: OBJECTIVE. To review disease spectrum and treatment patterns in a local Male infertility, male infertility clinic. DESIGN. Case series. SETTING. Male infertility, male infertility clinic in a teaching hospital in Hong Kong. Patients, patients, PATIENTS . Patients, patients, PATIENTS who were seen as new cases in a local Male infertility, male infertility clinic between January 2008 and December 2012. INTERVENTION. Infertility assessment and counselling on treatment options. MAIN OUTCOME MEASURES. Disease spectrum and treatment patterns. RESULTS. A total of 387 new Patients, patients, PATIENTS were assessed in the Male infertility, male infertility clinic. The mean age of the Patients, patients, PATIENTS and their female partners was 37.2 and 32.1 years, respectively. The median duration of infertility was 3 years. Among the Patients, patients, PATIENTS , 36.2% had azoospermia , 8.0% had Patients, patients, PATIENTS2108 , and 48.3% of Patients, patients, PATIENTS had other abnormalities in semen parameters . The commonest causes of Male infertility, male infertility were unknown (idiopathic), clinically significant varicoceles, Patients, patients, PATIENTS2108 , mumps after puberty, and erectile or ejaculatory dysfunction . Overall, 66.1% of Patients, patients, PATIENTS chose assisted reproductive treatment and 12.4% of Patients, patients, PATIENTS preferred surgical correction of reversible Male infertility, male infertility conditions. Altogether 36.7% of Patients, patients, PATIENTS required either surgical sperm retrieval or correction of Male infertility, male infertility conditions. CONCLUSIONS. The present study provided important local data on the disease spectrum and treatment patterns in a Male infertility, male infertility clinic. The incidences of azoospermia and Patients, patients, PATIENTS2108 were much higher than those reported in the contemporary literature. A significant proportion of Patients, patients, PATIENTS required either surgical sperm retrieval or correction of reversible Male infertility, male infertility conditions.
| null |
1650_biomrc
|
Title: Hazard Ratio of Smoking on XXXX in Korea According to Histological Type and Gender.
PURPOSE: Using nationwide cancer incidence data, we examined whether the strength of the association of cigarette smoking with lung cancer risk differs according to major histological type and gender, taking account of other risk factors in the Korean population. METHODS: The study population derived from government employees and teachers aged 20 years and over who participated in a national health examination program in 1998 or 1999. Total study subjects were 1,357,447. After excluding 1556 subjects who were treated with lung cancer during 1998-2000, we restricted our analysis to 1,355,891 cases. We followed up those 1,355,891 subjects who were cancer -free at baseline until December 31, 2010. The incident cancer cases were identified from the Korea Central Cancer Registry, which is a nationwide hospital-based cancer registry system that includes 94 % of the university hospitals and 96 % of the resident training hospitals of the country. RESULTS: A higher risk for having ever smoked was observed for squamous-cell and small-cell women, men89 in both women, men and women, men . Heavy and long-term smokers were at higher risk for these women, men89 . Significant associations with quantity and duration-related factors were observed mainly among women, men . These findings indicate that smoking is closely related to the risk of squamous-cell and small-cell women, men89 among women, men as well as women, men . However, the magnitude of smoking-related lung cancer risk is likely to differ between women, men and women, men . CONCLUSION: The hazard ratios for all types of lung cancer were significantly higher in male current smokers than in male never smokers. In case of women, men , the hazard ratios for adenocarcinoma were not different between current smokers and never smokers. The hazard ratios we found, however, were lower than those reported in Western countries and in Korea, but consistent with those reported in North-eastern Asian countries.
| null |
3702_biomrc
|
Title: Expression of the inducible form of XXXX synthase by reactive astrocytes after transient global @entity63 .
We recently demonstrated that reactive astrocytes express NADPH diaphorase activity, a marker for Nitric Oxide, nitric oxide Synthase, following transient global ischemia (Neuroscience Letters 154: 125-128). There has been little evidence that astrocytes express Nitric Oxide, nitric oxide Synthase or produce NO ( Nitric Oxide, nitric oxide ) in vivo; although in vitro experiments have shown that cultured astrocytes can produce NO. To determine whether reactive astrocytes express inducible form of NOS ( iNOS ) in vivo, we studied the pathological changes of rat hippocampus by immunohistochemistry after 10 minutes of transient global ischemia , which results in the selective delayed death of CA1 pyramidal cells and marked gliosis in the CA1 subfield. In the normal hippocampus, astrocytes express neither NADPH diaphorase activity nor iNOS . After ischemia , the temporal and spatial pattern of iNOS , NADPH diaphorase, and GFAP are very similar, indicating that reactive astrocytes express iNOS . Double staining for NADPH diaphorase and GFAP , or iNOS and GFAP confirmed that reactive astrocytes express both NADPH diaphorase activity and iNOS immunoreactivity. These changes were observed three day after ischemia and increased in prominence from one week to one month. The staining pattern of OX42, an antibody that recognizes both microglia and macrophages, is spatially and temporally distinct from the pattern of NADPH diaphorase and iNOS staining. Thus, we conclude that transient global ischemia induces iNOS primarily in reactive astrocytes. This increase in NOS expression and, presumably, NO production by reactive astrocytes may play a role in the process of delayed neuronal death or in the remodeling responses that occur after ischemic damage .
| null |
1657_biomrc
|
Title: Unilateral @entity75 in childhood: performance on the XXXX .
Comprehension of connected language as assessed by the children, patients, Children062 ( children, patients, Children062 ) was studied in 17 children, patients, Children with left hemisphere lesions (LL) and 11 with right hemisphere lesions (RL). LL children, patients, Children 's significantly lower performance on several subtests than left controls (LC) matched by age, sex, race, and social class appeared to be related to the memory demands of these subtests rather than the limited syntactic elements assessed by the children, patients, Children062 . LL subjects requested significantly more command repetitions than control or RL subjects and when a repetition was not requested LL subjects often responded with immediacy. Although RL children, patients, Children tended to perform lower than right matched controls (RC), these differences were not significant nor readily related to either the memory or specific linguistic structures assessed. RL subjects required fewer command repetitions than LL subjects and exhibited a significantly greater frequency of immediate responses than controls or LL subjects. While based on few children, patients, Children , a trend for LL children, patients, Children with retrorolandic lesions to perform more poorly than those with subcortical lesions, brain lesions, left prerolandic lesions was suggested. No systematic difference in performance was apparent for children, patients, Children with left cortical vs. left subcortical lesions, brain lesions, left prerolandic lesions or among discrete sites of lesions within the right hemisphere. children, patients, Children with left lesions prior to 1 year of age performed no better and, in several instances, significantly poorer than LL children, patients, Children sustaining lesions after 1 year of age. Among RL subjects, those sustaining lesions after 1 year of age had greater difficulty than those with lesion onset before 1 year of age, especially on linguistic elements which seemed to be dependent upon visual spatial properties. Further studies are needed to evaluate the comprehension of more complex linguistic structures among children, patients, Children with unilateral subcortical lesions, brain lesions, left prerolandic lesions as well as to study the role of more basic factors such as memory and attention in explaining the present findings.
| null |
1667_biomrc
|
Title: Should imaging be a component of XXXX remission criteria? A comparison between traditional and modified composite remission scores and imaging assessments.
OBJECTIVES: Patients, patients can fulfil clinical criteria for remission, yet still have evidence of synovitis detectable clinically and by ultrasound, and this is associated with structural damage. Stricter remission criteria may more accurately reflect true remission (no synovitis ). This hypothesis was examined by studying Patients, patients using more stringent thresholds for clinical remission and determining their levels of ultrasound synovitis . METHODS: Rheumatoid arthritis Patients, patients with a disease activity score in 28 joints (DAS28) <=2.6 for at least 6 months were classified using standard and more stringent DAS28 and simplified disease activity index (SDAI) remission thresholds and the corresponding clinical and ultrasound imaging measures of synovitis recorded. RESULTS: 128 Patients, patients (all DAS28 <2.6, median DAS28 1.70) receiving either disease-modifying antirheumatic drugs alone (n=66) or with a tumour necrosis factor blocker (n=62) were recruited. Of the 640 imaged joints, 5% had moderate or severe power Doppler (PD) activity, 8% were clinically swollen and 1% tender. In Patients, patients fulfilling DAS28, American College of Rheumatology or SDAI remission criteria, moderate or severe PD activity was present in 21%, 15% and 19%, respectively. More stringent DAS28 and SDAI criteria reduced the mean number of swollen and tender joints (p<0.001) but not the percentage of Patients, patients with PD activity: 32 Patients, patients had a DAS28 <1.17 but eight (25%) had significant PD activity. CONCLUSION: Using more stringent remission criteria resulted in reduced signs and symptoms of inflammation , but the percentage of joints with PD activity was not reduced, even in those without signs or symptoms. These data suggest that clinical criteria are sufficiently insensitive to detect low but clinically relevant levels of inflammation accurately.
| null |
3716_biomrc
|
Title: [Hip arthroscopy after luxatio obturatoria. With contralateral unstable pelvic ring XXXX ].
Traumatic dislocation of the hip is a severe injury. Even in cases of an early uncomplicated repositioning there is a high risk of associated intra-articular injuries, such as lesions of the labrum, ruptures of the ligament of the head of the femur and loose bodies. The degree of damage caused by hip dislocation, dislocation of the hip becomes apparent with a highly increased risk of developing postinjury osteoarthritis after hip dislocation, dislocation of the hip . Some of the major patient6 resulting from hip dislocation, dislocation of the hip , e.g. loose bodies, can be detected by computed tomography and magnetic resonance imaging and can be effectively addressed by hip arthroscopy, thus aiming at reducing the acute symptoms and the risk of postinjury osteoarthritis . The force effect which causes hip dislocation, dislocation of the hip can generate severe associated extra-articular injures as in the case described with an unstable patient74 of the pelvis. This patient30 had to be considered while planning the operative therapy and rehabilitation. A patient presented after a traffic accident with a luxatio obturatoria on the right side and a complex patient74 of the left pelvis including the posterior ring and the anterior wall of the acetabulum. After reposition of the right hip and operative therapy of the left side, a loose body was identified in the right hip joint during the computed tomography control of the osteosynthesis. Before patient mobilization extraction of the intra-articular loose body was performed arthroscopically. This was done in consideration of the reduced possibility of distraction due to the osteosynthesis on the contralateral side. Attention was particularly paid to the risk of intra-abdominal fluid extravasation (IAFE). This syndrome is described as a severe complication during hip arthoscopy especially in cases of defects of the hip capsule as assumed after hip dislocation, dislocation of the hip and magnetic resonance imaging.
| null |
3722_biomrc
|
Title: The compressive stiffness of XXXX pediatric heads.
UNASSIGNED: Head injury, head injuries, head injury is a persistent and costly problem for both children, human, people and adults. Globally, approximately 10 million children, human, people are hospitalized each year for Head injury, head injuries, head injury . Knowing the structural properties of the head is important for modeling the response of the head in impact, and for providing insights into mechanisms of Head injury, head injuries, head injury . Hence, the goal of this study was to measure the sub-injurious structural stiffness of whole pediatric heads. 12 cadaveric pediatric (20-week-gestation to 16 years old) heads were tested in a battery of viscoelastic compression tests. The heads were compressed in both the lateral and anterior-posterior directions to 5% of gauge length at normalized deformation rates of 0.0005/s, 0.01/s, 0.1/s, and 0.3/s. Because of the non-linear nature of the response, linear regression models were used to calculate toe region (<2.5%) and elastic region (>2.5%) stiffness separately so that meaningful comparisons could be made across rate, age, and direction. The results showed that age was the dominant factor in predicting the structural stiffness of the children, human, people head. A large and statistically significant increase in the stiffness of both the toe region and the elastic region was observed with increasing age (p<0.0001), but no significant difference was seen across direction or normalized deformation rate. The stiffness of the elastic region increased from as low as 5N/mm in the neonate to >4500N/mm in the 16 year old. The changes in stiffness with age may be attributed to the disappearance of soft sutures and the thickening of skull bones with age.
| null |
3725_biomrc
|
Title: Clinical implications of @entity6912 *28 genotype testing in XXXX @entity1 .
BACKGROUND: Metastatic participants, Patients, patients4 is frequently treated with irinotecan , a topoisomerase-I inhibitor. The UGT1A1 gene encodes for an enzyme that metabolizes irinotecan , and its genetic variants were shown to be associated with increased participants, Patients, patients37 . We evaluated clinical outcomes associated with the UGT1A1 *28 variant. METHODS: The study included 329 participants, Patients, patients4 participants, Patients, patients from the Israeli population-based Molecular Epidemiology of participants, Patients, patients4 who were treated with a chemotherapy regimen that included irinotecan . participants, Patients, patients with metastases or disease recurrence were followed up for a median period of 2 years after occurrence of the event. Study end points were appearance of grade 3-4 hematological and gastroenterological participants, Patients, patients37 , hospitalization due to toxic events (mostly participants, Patients, patients398 , fever , diarrhea , or vomiting ), length of hospitalization, and overall survival. UGT1A1 *28 was genotyped from peripheral blood DNA by fragment analysis and reported as number of TATA sequence repeats in the promoter of the gene. RESULTS: The 7/7 variant of UGT1A1 *28 was detected in 11.9% of the 329 participants, Patients, patients . Grade 3-4 hematological participants, Patients, patients37 was significantly higher in 7/7 carriers compared with 6/7 and 6/6 carriers (48.0%,10.2%, and 7.7% respectively; P < .001), as was the risk of participants, Patients, patients37 -related hospitalization (45.8%, 25.3%, and 14.4% respectively; P = .001). Both short-term death within 2 months of treatment start (12.8%, 5.2%, and 2.9%, respectively) and median overall survival (1.6, 2.0, and 2.4 years, respectively; P = .01) were significantly worse in the 7/7 carriers. The age/stage-adjusted hazard ratio for participants, Patients, patients with the 7/7 genotype compared with 6/6 was 1.7 (95% confidence interval, 1.1-2.3). CONCLUSIONS: The UGT1A1 *28 7/7 genotype is strongly associated with severe hematological participants, Patients, patients37 and higher hospitalization rate and predicts lower survival of participants, Patients, patients4 in users of irinotecan .
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3737_biomrc
|
Title: Measurement of @entity3795 -induced @entity1931 and XXXX -induced @entity1337 in @entity35 : dorsal vs plantar mechanical stimulation of the hindpaw.
OBJECTIVE: To compare the sensitivity of stimulating the plantar and dorsal hindpaw surfaces in the detection of mechanical allodynia and morphine analgesia . BACKGROUND: Several approaches are used to assess nociceptive reactivity to mechanical stimulation in animal models of pain . Although certain techniques seem to be favored for studying specific nociceptive conditions, the differences between techniques have not been directly compared and characterized. We chose to compare methods employing stimulation applied to the dorsum of the paw with stimulation of the plantar surface to demonstrate the utility of each approach in determining baseline nociceptive thresholds, changes in those thresholds after injury, and analgesic efficacy. METHODS: Withdrawal thresholds from mechanical stimulation applied to the dorsal and plantar surface of the hindpaw were measured in rats treated with morphine after receiving subcutaneous injections of complete Freund's adjuvant ( CFA ) using Semmes-Weinstein (S-W) monofilaments and electro von Frey (EVF) stimulation. RESULTS: In contrast to stimulation of the dorsal surface, plantar hindpaw stimulation seldom elicited an aversive withdrawal response. Differences in withdrawal response from baseline were only detectable within the first 5 hours post- CFA and only with EVF stimulation. No significant differences in stimulation techniques were observed after the initial 5-hour window. Effective dose 50 (ED(50)) for analgesic efficacy was consistently lower using dorsal stimulation. CONCLUSIONS: Stimulation of the plantar surface of the paw is superior for detecting small changes in paw sensitivity at very low stimulus intensities, whereas stimulation of the dorsal surface is superior for delineating baseline pain thresholds and for detecting robust analgesia . CLINICAL RELEVANCE: Reliable and sensitive assessment of animal pain behaviors is critical to translational pain research. This study demonstrates the importance of using proper test protocols in animal studies and its implication in preclinical screening of potential analgesics.
| null |
3739_biomrc
|
Title: Survival of Californian @entity1 with XXXX , 1994-1996: a population-based study.
OBJECTIVE: The objective was to identify demographic, clinical, and provider characteristics that might influence cancer, Cancer, advanced-stage disease survival in a cohort of Northern California women, patient using a population-based cancer, Cancer, advanced-stage disease registry. METHODS: We used California cancer, Cancer, advanced-stage disease Registry data to evaluate survival in 1051 Northern California women, patient who were diagnosed with ovarian cancer, epithelial ovarian cancer between 1994 and 1996 and underwent a surgical procedure for their cancer, Cancer, advanced-stage disease . Chemotherapy data from the cancer, Cancer, advanced-stage disease registry were supplemented with a physician survey and medical record review. Database linkages with census and hospital discharge data provided socioeconomic and comorbidity measures. Kaplan-Meier method was used to generate survival curves and multivariate Cox proportional hazard models were used to evaluate the effect of different factors on survival. RESULTS: Crude 5-year survival was 82, 57, 28, and 10% for women, patient with FIGO stage IC, II, III, and IV disease, respectively. Adverse survival was most strongly influenced by advanced stages III and IV with a hazards ratio ranging from 8 to 11.8 compared to stage IC disease . Multivariate analysis also identified other adverse factors including high grade and other adverse histologies, age over 45, and rural location. Chemotherapy decreased the risk of death by 50% if the women, patient had cancer, Cancer, advanced-stage disease . Medical comorbidity increased the risk of death by 40%. Survival was not influenced by race/ethnicity, socioeconomic status, physician specialty, or hospital characteristics. CONCLUSION: Advanced age remains an adverse prognostic factor even after adjustment for treatment and comorbidity factors. These results also suggest that there may be important regional differences in ovarian cancer, epithelial ovarian cancer survival.
| null |
3742_biomrc
|
Title: Autoimmune hemolytic anemia following XXXX -adjuvanted @entity683 vaccine administration: a report of two cases.
OBJECTIVE: To describe 2 cases of autoimmune hemolytic anemia, AIHA ( autoimmune hemolytic anemia, AIHA ) following the administration of Patients, woman, patient156 -adjuvanted influenza vaccine. CASE SUMMARY: An 83-year-old white Patients, woman, patient developed persistent hyperpyrexia , polyarthralgia , and lower limb hypostenia about 2 days after receiving influenza vaccine. Clinical signs and laboratory evaluations suggested autoimmune hemolytic anemia, AIHA . The Patients, woman, patient was treated with high-dose corticosteroids and immunoglobulins, and her clinical condition improved. A 74-year-old white Patients, woman, patient developed severe abdominal pain and Patients, woman, patient395 3 days after the administration of influenza vaccine. Clinical signs and laboratory evaluations disclosed autoimmune hemolytic anemia, AIHA . She was treated with corticosteroids , rehydration, and blood transfusion; however, she died about 48 hours after hospitalization. DISCUSSION: autoimmune hemolytic anemia, AIHA has been rarely described following influenza vaccine administration. In the cases described here, the causal relationship between influenza vaccination and the occurrence of autoimmune hemolytic anemia, AIHA , assessed by means of World Health Organization criteria, was scored as probable. It has been proposed that the mechanism whereby vaccines induce autoimmune responses, autoimmune disorders can be molecular mimicry, although a possible role of other vaccine constituents, with particular regard for adjuvants, such as Patients, woman, patient156 , can not be excluded. Squalene , a constituent of Patients, woman, patient156 , has been suggested as a causative agent of autoimmune reactions. However, it is not clear how and under what conditions squalene can cause immune responses. CONCLUSIONS: Influenza vaccination may rarely trigger severe autoimmune hemolytic anemia, AIHA , shortly after vaccine administration. A mechanism of molecular mimicry is probably involved in the development of these reactions, although the possible role of adjuvants can not be excluded. Patients, woman, patient should be instructed to report signs and symptoms of autoimmune responses, autoimmune disorders occurring in the first weeks after administration of influenza vaccine.
| null |
1694_biomrc
|
Title: Tissue inhibitor of metalloproteinase-I and interstitial collagenase expression in @entity3619 and activated XXXX hepatic lipocytes.
1. Activated hepatic lipocytes are central to the pathogenesis of liver fibrosis as the principal source of both interstitial collagens and matrix-degrading metalloproteinases. In progressive fibrosis there is a failure to degrade interstitial collagens with a reported decrease in collagenase activity. In these studies we investigate expression of the potent collagenase inhibitor, tissue inhibitor of metalloproteinase-1, and interstitial collagenase in end-stage autoimmune chronic active hepatitis and activated human hepatic lipocytes in culture. 2. Messenger RNA transcripts for interstitial collagenase and tissue inhibitor of metalloproteinase-1 in explanted human liver were quantified by ribonuclease protection assay and densitometric analysis. This indicated that tissue inhibitor of metalloproteinase-1 and interstitial collagenase expression in autoimmune chronic active hepatitis were also coordinately up-regulated. 3. Using Northern analysis of RNA from human lipocytes in primary culture on plastic, mRNA for interstitial collagenase could not be detected in unstimulated cells but was present after stimulation with tumour necrosis factor alpha. Tissue inhibitor of metalloproteinase-1 mRNA was present in unstimulated lipocytes and up-regulated fivefold in response to tumour necrosis factor alpha. Using activity assay of serum-free conditioned media, interstitial collagenase could not be detected in unstimulated primary cultures, primary cultures stimulated with tumour necrosis factor alpha or transforming growth factor beta-1 (n = 3 and n = 4 respectively) or in passaged lipocytes (n = 6). In contrast, free tissue inhibitor of metalloproteinase-1 activity was present in unstimulated and passaged cultures and this was increased in response to tumour necrosis factor alpha and transforming growth factor beta-1 .(ABSTRACT TRUNCATED AT 250 WORDS)
| null |
3744_biomrc
|
Title: Improved XXXX control after cardiac surgery: results of a randomized, double-blind, clinical trial.
OBJECTIVE: We sought to determine whether a continuous regional infusion of a local anesthetic delivered to the operative site would result in decreased levels of postoperative pain and narcotic requirements for Patients, patients who undergo a standard median sternotomy for cardiac surgery. METHODS: A double-blind, randomized, controlled trial was conducted at a single center. Patients, patients who were undergoing elective coronary artery bypass graft surgery alone or combined with laser transmyocardial revascularization received bilateral intercostal nerve blocks with either Patients, patients342 or saline. At wound closure, 2 catheters with multiple side openings were inserted percutaneously and placed directly over the sternum. The same agent ( Patients, patients342 vs saline) was then administered as a continuous regional infusion for 48 hours through an elastomeric pump. Requirements for postoperative systemic narcotic analgesics and Patients, patients58 assessment scores were recorded for 72 hours after the operation. Secondary outcome measures were hospital length of stay and pulmonary function test results. Patients, patients58 scores and narcotic use on the second postoperative day were also compared to avoid the confounding influence of anesthesia administered at the time of the operation. RESULTS: The total amount of Patients, patients337 required by the Patients, patients342 group was significantly less than that of the control group (47.3 vs 78.7 mg, respectively; P =.038). The Patients, patients342 group required less narcotics on postoperative day 2 as well (15.5 vs 29.4 mg, P =.025). The mean overall Patients, patients58 scores for the Patients, patients342 group were significantly less than the mean overall scores for the normal saline group (1.6 vs 2.6, respectively; P =.005). Patients, patients receiving Patients, patients342 had a mean length of stay of 5.2 days compared with 8.2 days for Patients, patients in the normal saline group (P =.001). Excluding the data from outliers (length of stay = 39 days), the normal saline group mean length of stay was 6.3 days (P <.01). There was no difference in assessment of pulmonary function. CONCLUSION: Continuous delivery of local anesthetics significantly improved postoperative pain control while decreasing the amount of Patients, patients337 required in Patients, patients who underwent standard median sternotomy. There was also a significant decrease in hospital length of stay, which is likely to result in significant cost reductions.
| null |
1697_biomrc
|
Title: Interactions between an alpha2-adrenergic antagonist and a beta3-adrenergic agonist on the expression of XXXX and @entity5485 in rats.
This experimental trial was devised to assess whether selective beta3-adrenergic receptor (AR) stimulation and simultaneous blockade of alpha2-AR would affect thermoregulation. With this purpose, the individual and combined administration of a beta-AR agonist, trecadrine , and an alpha2-AR antagonist, yohimbine, Yohimbine , were evaluated. yohimbine, Yohimbine produced a marked decrease (p < 0.001) in body temperature one hour after administration (5 mg kg(-1), i.p.) and blocked the thermogenic effect of trecadrine (1 mg kg(-1), i.p.) when simultaneously administered. Uncoupling protein-2 expression in skeletal muscle was downregulated (p < 0.05) by trecadrine , while yohimbine, Yohimbine had no effect. White adipose tissue UCP2 and muscle UCP3 were not modified by either trecadrine or yohimbine, Yohimbine administration. Liver UCP2 mRNA expression was significantly decreased by yohimbine, Yohimbine (p < 0.05). However, this downregulation does not seem to explain the reduction in temperature produced by yohimbine, Yohimbine given the fact that trecadrine produced a similar downregulation of hepatic UCP2 (p < 0.05). The present work indicates that alpha2-AR antagonism blocks the thermogenic effects mediated by beta3-AR stimulation, contrary to our expectations, suggesting a possible interplay between both mechanisms. Moreover, these effects are not apparently explained by changes in UCP2 and UCP3 .
| null |
3745_biomrc
|
Title: Therapeutic impact of XXXX bone marrow stromal cells expanded by animal serum-free medium for @entity385 in @entity35 .
BACKGROUND: The donor cell culture in animal serum-free medium is important for the clinical application of cell transplantation therapy. Recently, human -derived platelet lysate (PL) gained interest as a substitute for fetal calf serum (FCS), but there are no studies that evaluate the validity of human bone marrow stromal cells (hBMSCs) expanded with PL-containing medium for central nervous system disorders . OBJECTIVE: To test the hypothesis that hBMSCs expanded with FCS-free, PL-containing medium can promote functional recovery after cerebral infarct . METHODS: hBMSCs were cultured in the FCS- or PL-containing medium. Cell-growth kinetics were analyzed. The vehicle or hBMSCs was stereotactically transplanted into the ipsilateral striatum of the rats subjected to permanent middle cerebral artery occlusion 7 days after the insult. Motor function was assessed for 8 weeks, and the fate of transplanted hBMSCs was examined using immunohistochemistry. RESULTS: There was no significant difference in hBMSC expansion between the 2 groups. Transplantation of hBMSCs expanded with the FCS- or PL-containing medium equally promoted functional recovery compared with the vehicle group. Histological analysis revealed that there were no significant differences in their migration, survival, and neural differentiation in the human188 brain between the 2 groups. CONCLUSION: hBMSCs expanded with PL-containing medium retained their capacity of migration, survival, and differentiation and significantly promoted functional recovery when stereotactically transplanted into the human188 brain. The PL may be a clinically valuable and safe substitute for FCS in expanding hBMSCs to regenerate the human188 brain.
| null |
1700_biomrc
|
Title: Precautions surrounding blood transfusion in autoimmune haemolytic XXXX are overestimated.
BACKGROUND: It is very evident that many precautions are taken regarding transfusion of red blood cells in patients, patient with autoimmune haemolytic anaemia . Frequently, considerable efforts are made to examine the indication and serological compatibility prior to transfusion in such patients, patient . However, at times, this may unnecessarily jeopardize patients, patient who urgently require a red blood cell transfusion. MATERIALS AND METHODS: Thirty-six patients, patient with warm-type autoimmune haemolytic anaemia were included in this study. All patients, patient had reactive serum autoantibodies and required blood transfusion. Standard serological assays were employed for the detection and characterization of antibodies to red blood cells. RESULTS: A positive direct antiglobulin test was observed in all 36 patients, patient , in addition to detectable antibodies in both the eluate and serum. Significant alloantibodies were detected in the serum samples of three patients (anti-c, anti-JK(a), and anti-E). In 32 patients, patient , red blood cell transfusion was administered with no significant haemolytic transfusion reactions due to auto- and/or allo-antibodies. Due to overestimation of positive cross-matches three patients, patient received no transfusion or delayed transfusion and died, and one patients, patient died due to unrecognised patients, patient90 and anaemia which was attributed to an ineffective red blood cell transfusion. DISCUSSION: Many of the reported recommendations regarding transfusion of red blood cells in autoimmune haemolytic anaemia are highly questionable, and positive serological cross-matches should not result in a delay or refusal of necessary blood transfusions.
| null |
1702_biomrc
|
Title: Immortalization of a @entity1 XXXX cell line by continuous in vitro passage: possible involvement of chromosome 1 in @entity5 progression.
A non-tumorigenic epithelial cell line designated PC/AA, derived from a large pre-malignant adenoma-carcinoma, colorectal adenoma from a human, patient with human, patient412 (also referred to as hereditary adenomatosis of the colon and rectum ) has become immortal in vitro. PC/AA has been passaged in vitro continuously for over 4 years and shows no signs of senescence. At early passage, PC/AA has a normal diploid karyotype but with late passage is showing signs of progression, becoming aneuploid and displaying signs of morphological transformation . Every cell examined of late-passage PC/AA has an isochromosome (1q), and one other marker chromosome which is probably derived from an additional chromosome 8. The majority of cells examined have 48 chromosomes. Despite showing signs of progression in vitro, late-passage PC/AA has remained non-tumorigenic in athymic human, patient9 and retained morphological differentiation characteristics of colonic cells, in particular the ability to synthesize and secrete mucin. Two other cell lines derived from small adenomas, adenoma did not become immortal in vitro and were also non-tumorigenic in athymic human, patient9 . The isolation of an immortal pre-malignant human, patient epithelial cell line could prove invaluable in studies on human, patient human, patient05 and tumour progression. Our results, showing that only a large adenomas, adenoma and no small adenomas, adenoma have given rise to immortal cell lines, raise the possibility that the acquisition of in vitro immortality is associated with a relatively late stage in the adenoma-carcinoma, colorectal adenoma sequence. The possible involvement of chromosome 1 in tumour progression is discussed.
| null |
3752_biomrc
|
Title: Preoperative @entity1148 and poor prognostic factors in XXXX .
This study aimed to evaluate the prevalence of preoperative Patients, patients148 and its prognostic significance in Thai Patients, patients with Patients, patients204 . We retrospectively reviewed the medical records of 238 cases who had undergone surgical staging procedures between January 2005 and December 2008. Associations between clinicopathological variables and preoperative platelet counts were analyzed using Pearson's chi square or two- tailed Fisher's exact tests. Survival analysis was performed with Kaplan-Meier estimates. Univariate and Cox - regression models were used to evaluate the prognostic impact of various factors including platelet count in terms of disease-free survival and overall survival. The mean preoperative platelet count was 315,437/ L (SD 100,167/ L). Patients, patients who had advanced stage, adnexal involvement, lymph node metastasis , and positive peritoneal cytology had significantly higher mean preoperative platelet counts when compared with those who had not. We found Patients, patients148 (platelet count greater than 400,000/ L) in 18.1% of our Patients, patients with Patients, patients204 . These had significant higher rates of advanced stage, cervical involvement, adnexal involvement, positive peritoneal cytology, and lymph node involvement than Patients, patients with a normal pretreatment platelet count. The 5-year disease-free survival and overall survival were significantly lower in Patients, patients who had Patients, patients148 compared with those who had not (67.4% vs. 85.1%, p=0.001 and 86.0% vs. 94.9%, p=0.034, respectively). Patients, patients148 was shown to be a prognostic factor in the univariate but not the multivariate analysis. In conclusion, presence of Patients, patients148 is not uncommon in Patients, patients204 and may reflect unfavorable prognostic factors but its prognostic impact on survival needs to be clarified in further studies.
| null |
3755_biomrc
|
Title: Local anesthesia with @entity1425 is safe and effective for oral surgery in XXXX with @entity6 and @entity301 : a prospective randomized study.
OBJECTIVE: To investigate the variations in blood glucose, Glucose levels, hemodynamic effects and Patients, patients, patient Patients, patients, patient48 scores during tooth extraction in Patients, patients, patient with type 2 diabetes mellitus T2DM and coronary disease under local anesthesia with 2% lidocaine with or without Patients, patients, patient425 . STUDY DESIGN: This is a prospective randomized study of 70 Patients, patients, patient with T2DM with coronary disease who underwent oral surgery. The study was double blind with respect to the glycemia measurements. Blood glucose, Glucose levels were continuously monitored for 24 hours using the MiniMed Continuous glucose, Glucose Monitoring System. Patients, patients, patient were randomized into two groups: 35 Patients, patients, patient received 5.4 mL of 2% lidocaine , and 35 Patients, patients, patient received 5.4 mL of 2% lidocaine with 1:100,000 Patients, patients, patient425 . Hemodynamic parameters (blood pressure and heart rate) and Patients, patients, patient48 levels were also evaluated. RESULTS: There was no difference in blood glucose, Glucose levels between the groups at each time point evaluated. Surprisingly, both groups demonstrated a significant decrease in blood glucose, Glucose levels over time. The groups showed no significant differences in hemodynamic and Patients, patients, patient48 status parameters. CONCLUSION: The administration of 5.4 mL of 2% lidocaine with Patients, patients, patient425 neither caused hyperglycemia nor had any significant impact on hemodynamic or Patients, patients, patient48 parameters. However, lower blood glucose, Glucose levels were observed. This is the first report using continuous blood glucose, Glucose monitoring to show the benefits and lack of side effects of local anesthesia with Patients, patients, patient425 in Patients, patients, patient with type 2 diabetes mellitus and coronary disease .
| null |
3759_biomrc
|
Title: Effect of a @entity1160 -supplemented enteral diet on XXXX -induced @entity1964 .
Administration of an elemental diet to rats given methotrexate ( MTX ), 20 mg/kg intraperitoneally (ip), results in 100% mortality from severe enterocolitis . Previous studies indicate that glutamine ( GLN ), which is not present in elemental diets, is the preferred oxidative substrate for the gut and may facilitate intestinal recovery after injury. This study investigated the effects of a glutamine -supplemented elemental diet ( GLN -ED) on nutritional status, intestinal morphometry, bacterial translocation and survival in this lethal model of intestinal injury . Three experiments were performed. In the first experiment, rats received an intragastric elemental diet supplemented with either 2% GLN or an equivalent amount of glycine (Control). After 4 days animals received either MTX , 20 mg/kg ip, or saline ip and were killed 3 days later. The GLN -ED resulted in significantly decreased weight loss, improved nitrogen retention, and increased mucosal weight, protein, and DNA content of the jejunum and colon. In the second experiment rats were assigned to diet as in the first experiment, but all animals received MTX . Control diet animals died within 120 hrs of MTX administration. The GLN -ED group had significantly longer survival time and decreased mortality. In the third experiment animals were assigned to diet and MTX as in the first experiment. Ninety-six hrs later aortic blood cultures revealed enteric bacteremia in animals administered MTX . GLN -ED resulted in a significant reduction in the incidence of bacteremia . These experiments showed that a GLN -ED significantly improved nutritional status, decreased intestinal injury , decreased bacterial translocation, and resulted in improved survival in a lethal model of enterocolitis .
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3760_biomrc
|
Title: Treatment of Severe XXXX in ANCA Positive and Negative Small @entity1333 with Rituximab.
BACKGROUND/AIMS: Rituximab and glucocorticoids are a non-inferior alternative to cyclophosphamide and glucocorticoid therapy for induction of remission in antineutrophil cytoplasmic antibody (ANCA) associated Patients, patients333 (AAV) Patients, patients with moderate renal impairment, renal disease . The efficacy and safety of this approach in Patients, patients with severe renal impairment, renal disease are unknown. We report the outcomes and safety profile of rituximab and glucocorticoid therapy for induction of remission in Patients, patients with AAV and ANCA-negative Patients, patients333 presenting with severe renal impairment, renal disease . METHODS: A multicenter, retrospective, cohort study was conducted between 2005 and 2014. Patients, patients with new or relapsing disease with an estimated glomerular filtration rate (eGFR) of <=20 ml/min/1.73 m(2) treated with rituximab and glucocorticoid induction with or without plasmapheresis were included. Fourteen Patients, patients met the inclusion criteria. The primary outcomes were rate of remission and dialysis independence at 6 months. The secondary outcomes were eGFR at 6 months, end-stage renal disease, ESRD ( end-stage renal disease, ESRD ), survival rates and adverse events. RESULTS: All Patients, patients were Caucasian, and 57% were male. The mean eGFR was 12 ml/min/1.73 m(2) at diagnosis. All Patients, patients achieved remission with a median time to remission of 55 days. Seven Patients, patients required dialysis at presentation of which 5 Patients, patients recovered renal function and discontinued dialysis by 6-month follow-up. The mean eGFR for the 11 Patients, patients without end-stage renal disease, ESRD who completed 6-month follow-up was 33 ml/min/1.73 m(2). Four Patients, patients ultimately developed end-stage renal disease, ESRD , and one died during the follow-up period. CONCLUSION: Patients, patients with AAV and severe renal impairment, renal disease achieve high rates of remission and dialysis independence when treated with rituximab and glucocorticoids without cyclophosphamide . 2015 S. Karger AG, Basel.
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1717_biomrc
|
Title: Gastric secretion, gastroduodenal histological changes, and serum @entity8243 in chronic XXXX .
Controversial data have been reported on gastric acid secretion in patients, patient with patients, patient689 . Moreover, studies on gastroduodenal morphological changes in patients, patient with this disease and with other patients, patient67 -related conditions have given different results. Basal and penta- gastrin -stimulated gastric secretion, histological changes of gastric and duodenal mucosa, gastric metaplasia , and basal and meal-stimulated gastrin were measured in 21 patients, patient with chronic alcoholic pancreatitis and in the following pair-matched groups: 21 chronic alcoholics and 21 control subjects ( nonulcer dyspepsia ), and in 19 patients, patient with proven patients, patient575 of alcoholic origin. No patients, patient suffered from peptic patients, patient066 . Moreover, gastric secretion was also measured in 51 patients, patient with proven duodenal patients, patient066 and in 34 healthy subjects. Basal acid output in patients, patient with patients, patient689 was significantly higher (p less than 0.05) than in the other groups, except for the patients, patient with duodenal patients, patient066 . Peak acid output values in patients, patient with patients, patient689 were similar to those measured in patients, patient with duodenal patients, patient066 , and they were higher than in the healthy subject group and in patients, patient with patients, patient575 , but statistical significance was not attained for patients, patient with nonulcer dyspepsia . An increased frequency of duodenitis was found in patients, patient with patients, patient689 , whereas an increased frequency of gastric and duodenal mucosa, gastric metaplasia in the duodenal bulb was observed in all the patients, patient with patients, patient67 -related conditions considered. No relevant differences among the considered groups were found relating to gastric histological changes. Basal and meal-stimulated gastrin were similar in all the studied groups. This study suggests that in patients, patient with patients, patient689 there is increased gastric secretion and probably an increased capacity for secretion of acid. Moreover, in patients, patient with patients, patient689 , duodenitis seems to be frequent, but it probably is not directly related to chronic patients, patient67 consumption.
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1719_biomrc
|
Title: Non-Invasive Pulse Wave Analysis in a XXXX after Implantation of a Nitinol Aortic Endograft.
aneurysm, Endovascular aneurysm repair has been associated with changes in arterial stiffness, as estimated by pulse wave velocity ( patient22 ). This marker is influenced by the medical status of the patient , the elastic characteristics of the aneurysm, Endovascular aneurysm wall, and the presence of intraluminal thrombus . Therefore, in order to delineate the influence of the endograft implantation in the early post-operative period, we conducted non-invasively pulse wave analysis in a male patient with an patient028 containing no intraluminal thrombus , unremarkable past medical history, and absence of peripheral arterial disease . The estimated parameters were the systolic and diastolic pressure calculated at the aortic level (central pressures), patient22 , augmentation pressure (AP) and augmentation index (AI), pressure wave reflection magnitude (RM), and peripheral resistance. Central systolic and diastolic pressure decreased post-operatively. patient22 showed subtle changes from 11.6 to 10.6 and 10.9 m/s at 1-week and 1-month, respectively. Accordingly, the AI decreased from 28 to 14% and continued to drop to 25%. The AP decreased gradually from 15 to 6 and 4 mmHg. The wave RM dropped from 68 to 52% at 1-month. Finally, the peripheral resistance dropped from 1.41 to 0.99 and 0.85 dyn * s * cm(-5). Our example shows that the implantation of an aortic endograft can modify the pressure wave reflection over the aortic bifurcation without causing significant alterations in patient22 .
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1720_biomrc
|
Title: The role of B cells in the onset of the first demyelinating event of XXXX .
UNASSIGNED: Purpose. To evaluate the molecular pathways that operate in the early phase of acute optic neuritis by studying gene expression profiles of peripheral blood mononuclear cells (PBMCs) subpopulations including patients075 + B cells, CD14 + macrophages, CD4 + and CD8 + T cells. Methods. PBMC subpopulations were obtained from 11 patients5 patients within 96 hours of the acute onset of the first demyelinating event of ON and from 14 healthy subjects. Gene expression analysis was performed on samples from 6 ON patients and 9 healthy subjects (Affymetrix). Data was analyzed using Partek software and most informative genes (MIGs) were defined with p<0.01 and fold change >2.0. Verification of key MIGs was done by QRT-PCR and Western blot. Functional assay to test antigen presentation ability of B cells was performed. Results. Significantly differentiating gene expression signatures consisting of 467, 55, and 55 MIGs respective of patients075 +, CD14 + and CD4 + cells were identified between ON and healthy subjects. No MIGs was detected for CD8 + cells. The major involvement of patients075 + B cells in the early stage of ON was characterized by enrichment of genes involved in activation of immune mechanisms (p=3.2*10-25 to 2.5*10-3) including cellular immune response (p=7.1*10-12), B cells cellular growth and proliferation (p=1.0*10-7), activation of immune cells trafficking pathways (p=5.4*10-15 to 2.0*10-3), and stimulation of antigen presentation (p=8.9*10-11). Conclusions. Our findings demonstrate that patients075 + B cells play a significant role in the pathogenesis of the first demyelinating event of acute ON and suggest their role as possible target for immunomodulation.
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1721_biomrc
|
Title: Prediction of Lateral Pelvic Lymph-Node XXXX in Low @entity5 by Magnetic Resonance Imaging.
OBJECTIVE: This study was designed to evaluate the diagnostic accuracy of magnetic resonance imaging (MRI) for lateral pelvic lymph-node metastasis, metastases . patients, patient, PATIENTS : Eighty-four patients, patient, PATIENTS with primary lower rectal cancer were examined by MRI and subsequently underwent radical surgery with lateral pelvic lymph-node dissection, without preoperative treatment. Lateral lymph-node metastasis, metastases were assessed preoperatively by MRI, and the results were compared with the histopathological findings. The criterion for lateral lymph-node metastasis, metastases was any recognizable lymph node in the pelvic wall, regardless of diameter. RESULT: Lateral pelvic lymph-node metastasis, metastases was diagnosed on preoperative MRI in 16 patients, patient, PATIENTS (19.9 %). The overall patients, patient, PATIENTS -based sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of MRI were 75, 69.1, 36.4, 92.2, and 70.2 %, respectively. When a cut-off value of 10 mm was used for diagnosis, the corresponding values were 43.8, 98.5, 87.5, 88.1, and 88.1 %, respectively. The mean diameter of metastatic nodes (14.7 mm) was significantly larger than that of negative nodes (5.7 mm; P < 0.01). CONCLUSION: MRI is an effective technique for predicting lateral pelvic node involvement and thus may facilitate preoperative decision-making in rectal cancer treatment. A cut-off value of 10 mm is useful for avoiding unnecessary lateral lymph-node dissection.
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1726_biomrc
|
Title: A classification model for predicting eye disease in newly diagnosed @entity1 with type 2 XXXX .
UNASSIGNED: diabetes, Diabetic retinopathy may be present at the time type 2 diabetes, Diabetic retinopathy is diagnosed, and initial screening encompassing an eye examination performed by an ophthalmologist or optometrist is therefore recommended. However, proper screening for retinopathy, non-proliferative retinopathy may be challenging in many parts of the world. We hypothesized that simple, commonly available patients, patient characteristics can be used to identify patients, patient at high risk for having retinopathy, non-proliferative retinopathy . We investigated data from multiple years extracted from the National Health and Nutrition Examination Survey which holds information about blood glucose and eye examinations. Individuals with hitherto undiagnosed diabetes, Diabetic retinopathy were classified according to the presence or absence of retinopathy, non-proliferative retinopathy . Linear classification was used to predict which patients, patient had retinopathy, non-proliferative retinopathy at the time of diagnosis. A total of 266 individuals with undiagnosed diabetes, Diabetic retinopathy were identified from the cohorts. Of these, 222 individuals had no sign of retinopathy, non-proliferative retinopathy , whereas 44 had mild or moderate retinopathy, non-proliferative retinopathy . Using information regarding HbA1c, BMI, waist circumference, age, systolic blood pressure, urinary albumin, and urinary patients, patient011 , we were able to construct a model that predicts the presence of retinopathy, non-proliferative retinopathy with a positive predictive value of 22% and a negative predictive value of 99%. Only one true positive (1/44) with mild retinopathy, non-proliferative retinopathy was falsely classified. A classification model using readily available patients, patient information and routine biochemical measures can be used to identify patients, patient at high risk of having retinopathy, non-proliferative retinopathy at the time their diabetes, Diabetic retinopathy is diagnosed. The model may be used to identify high-risk patients, patient for retinopathy, non-proliferative retinopathy screening.
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1728_biomrc
|
Title: Intravesical transurethral electrotherapy for the XXXX .
Intravesical transurethral bladder stimulation is a rehabilitative and diagnostic technique for the patients, child, patient494 . The goal of therapy is 3-fold: 1) to achieve the sensation of bladder filling or the urge to void, 2) to initiate a detrusor contraction and 3) to achieve conscious urinary control. The procedure combines direct electrical stimulation of bladder receptors with visual biofeedback using patients, child, patient observance of a water manometric representation of the detrusor response. Since November 1984 we have evaluated and/or treated 24 patients, child, patient with a patients, child, patient494 . An electrocatheter is passed transurethrally into the bladder and the bladder is filled to a third of its capacity with normal saline. We then deliver 2 to 6 mA. every 3 seconds for 90 minutes. Full treatment usually requires 30 to 90 sessions. Of the 24 patients, child, patient 13 had only 1 evaluation and 10 had 3 to 39 sessions. Of those 10 patients, child, patient 7 had significant detrusor activity that had not been present before treatment and 4 have a sensation to void. The remaining patients, child, patient underwent 110 sessions. He has controlled detrusor contractions resulting in a normal voiding pattern. It appears that intravesical transurethral bladder stimulation may be helpful diagnostically to determine the stimulus response of bladder function and therapeutically to rehabilitate the patients, child, patient494 toward full control.
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3776_biomrc
|
Title: XXXX in pregnancy.
This article attempts to assess the nature, severity and management of the risks associated with pregnancy in chronic renal insufficiency and end-stage renal disease , including dialysis and transplant recipients. Women with serum women, Women, infants, infant011 levels of >125 mmol/l are at an increased risk for deterioration in renal function, women, Women, infants, infant01 with superimposed women, Women, infants, infant468 . Rigid control of women, Women, infants, infant01 is crucial for a successful pregnancy outcome. A range of antihypertensive drugs are available with angiotensin converting enzyme inhibitors being contraindicated. women, Women, infants, infant on dialysis have low fertility rates that return to normal following renal transplantation. Immunosuppresive drugs are not associated with women, Women, infants, infant54 . Transplant recipients are at an increased risk for infections that may have implications for the fetus. All groups have an increased risk for prematurity and intrauterine growth restriction. The percentage of pregnancies resulting in surviving women, Women, infants, infant in women, Women, infants, infant with women, Women, infants, infant77 and transplant recipients ranges from 80-100%. For women, Women, infants, infant who conceive after dialysis, the likelihood of a surviving women, Women, infants, infant is approximately 50%.
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1731_biomrc
|
Title: XXXX and paranasal sinuses: single-institution review of diagnosis, histology, and outcome.
OBJECTIVE: To study the incidence, treatment, and outcomes of adenocarcinomas, Adenocarcinoma, adenocarcinoma of the nose and paranasal sinuses over the last 15 years. DESIGN: Retrospective chart review of 20 patients, men identified and treated at the otolaryngology clinic of Zurich University Hospital between 1992 and 2007. MAIN OUTCOME MEASURES: Recurrence- and disease-free survival were the most important outcomes of interest. RESULTS: Twenty patients, men (16 patients, men ) with sinonasal adenocarcinomas, Adenocarcinoma, adenocarcinoma were found. The average age was 64 years. At the time of diagnosis, usually more than one sinus was involved and nasal obstruction was the most common symptom. In 57.9% of patients, men , the initial treatment was endoscopic surgery. Two-year recurrence-free survival was 48.5%, and 5-year disease-specific survival was 77.8%. CONCLUSIONS: Surgical resection is difficult owing to anatomic restraints, and adjuvant therapy must be considered in most patients, men . Endoscopic surgery was performed in a majority of patients, men , with outcomes comparable to those in the general literature. SIGNIFICANCE: adenocarcinomas, Adenocarcinoma, adenocarcinoma of the paranasal sinuses was found to have almost 80% 5-year survival if adequately treated surgically and with adjuvant intensity-modulated radiotherapy.
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3781_biomrc
|
Title: Cardiovascular effects of vasopressors in @entity1508 -anesthetized @entity235 before and after XXXX .
Exogenously administered vasopressors (sympathomimetics) were evaluated in halothane -anesthetized dogs to determine the effects of these drugs on cardiovascular function before and after hemorrhage . Six dogs were anesthetized with thiamylal sodium (20 mg/kg of body weight) and halothane (1.25 minimal alveolar concentration) in 100% oxygen . After instrumentation, cardiac output, systemic arterial blood pressure (SAP), heart rate (HR), left ventricular pressure, pulmonary arterial pressure, and an index of cardiac contractility (dP/dT) were measured. stroke, Stroke volume, cardiac index (CI), stroke, Stroke index (SI), rate-pressure product, and systemic vascular resistance (SVR) were calculated. epinephrine, Epinephrine (0.1, 0.3, and 0.5 micrograms/kg/min [low, medium, and high doses, respectively]) and Dobutamine, dobutamine (1, 5, and 10 micrograms/kg/min [low, medium, and high doses, respectively]) were infused. Methoxamine was given in a bolus of 0.22 mg/kg, IV. All measurements were taken at 2.5 minutes after infusion, and were repeated after removal of 40% of the estimated blood volume. Dobutamine, dobutamine administered at the low dose before hemorrhage increased SAP and dP/dT. At the high and medium dose, Dobutamine, dobutamine significantly increased CI, dP/dT, and SAP, with no significant change in HR or SVR. The medium dose of epinephrine, Epinephrine was the most effective dose of epinephrine, Epinephrine at increasing key variables (CI, SI, dP/dT). The response of CI and SI to this dose was not significantly different from the changes seen with high-dose administration of Dobutamine, dobutamine . The dP/dT was significantly lower with epinephrine, Epinephrine than with Dobutamine, dobutamine , and SVR and HR were unchanged with epinephrine, Epinephrine , except at the low dose, which decreased SVR.
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1735_biomrc
|
Title: An Effective Approach for Clustering XXXX Molecular Dynamics Trajectory Using Substrate-Binding Cavity Features.
UNASSIGNED: Protein receptor conformations, obtained from molecular dynamics, MD ( molecular dynamics, MD ) simulations, have become a promising treatment of its explicit flexibility in molecular docking experiments applied to drug discovery and development. However, incorporating the entire ensemble of molecular dynamics, MD conformations in docking experiments to screen large candidate compound libraries is currently an unfeasible task. Clustering algorithms have been widely used as a means to reduce such ensembles to a manageable size. Most studies investigate different algorithms using pairwise Root-Mean Square Deviation (RMSD) values for all, or part of the molecular dynamics, MD conformations. Nevertheless, the RMSD only may not be the most appropriate gauge to cluster conformations when the target receptor has a plastic active site, since they are influenced by changes that occur on other parts of the structure. Hence, we have applied two partitioning methods (k-means and k-medoids) and four agglomerative hierarchical methods (Complete linkage, Ward's, Unweighted Pair Group Method and Weighted Pair Group Method) to analyze and compare the quality of partitions between a data set composed of properties from an enzyme receptor substrate-binding cavity and two data sets created using different RMSD approaches. Ensembles of representative molecular dynamics, MD conformations were generated by selecting a medoid of each group from all partitions analyzed. We investigated the performance of our new method for evaluating binding conformation of drug candidates to the InhA enzyme, which were performed by cross-docking experiments between a 20 ns molecular dynamics, MD trajectory and 20 different ligands. Statistical analyses showed that the novel ensemble, which is represented by only 0.48% of the molecular dynamics, MD conformations, was able to reproduce 75% of all dynamic behaviors within the binding cavity for the docking experiments performed. Moreover, this new approach not only outperforms the other two RMSD-clustering solutions, but it also shows to be a promising strategy to distill biologically relevant information from molecular dynamics, MD trajectories, especially for docking purposes.
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3786_biomrc
|
Title: Open pelvic lymph node dissection for XXXX : a reassessment.
OBJECTIVES: To provide a risk-to-benefit analysis of open staging pelvic lymph node dissection (PLND) for prostate cancer . METHODS: The medical records of all patients presenting with prostate cancer from July 1989 to April 1994 were reviewed. A total of 245 patients with clinically localized disease were selected to undergo radical retropubic prostatectomy (RRP) preceded by open PLND. Univariate and multivariate analyses were performed to evaluate the predictive value of the preoperative serum patients486 concentration, clinical stage, and Gleason score with regard to final nodal status. The cost and morbidity associated with PLND in the setting of RRP was also defined. RESULTS: Overall, only 16 patients (6.5%) had lymph node metastasis, metastases . Lymph node involvement correlated significantly with elevated serum patients486 values (P = 0.0001), high Gleason score (P = 0.0022), and advanced clinical stage (P = 0.0001). Lymph node metastasis, metastases were particularly uncommon in patients with nonpalpable tumors (1 of 67 [1.5%]), patients486 values less than 10 (2 of 154 [1.3%]), and Gleason score less than 6 (1 of 26 [3.8%]). Overall, 179 patients (73.1%) presented with at least one or more of these favorable characteristics, and only 4 (2.2%) had lymph node involvement. Complications related to the lymphadenectomy occurred in 10 patients (4.1%). The cost per metastasis, metastases diagnosed in patients with low-risk characteristics was approximatley 43,600. CONCLUSIONS: An open staging PLND may no longer be justified on a routine basis in patients undergoing radical retropubic prostatectomy.
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3792_biomrc
|
Title: XXXX cycle and its possible involvement in the regulation of cytoskeleton-membrane interactions.
Receptor-mediated activation of many cells, including blood platelets, leads to changes at the cytoplasmic side of the membrane. In platelets, phospholipases, such as phospholipase C and phospholipase A2 , have been shown to become activated. From phospholipids they generate the second messengers diacylglycerol and human9260 (s) and human718 , respectively. At the same time, actin polymerization and reorganization of actin filaments into bundles and networks occurs. Here, the association of lipids, radiolabeled either with saturated ( palmitic acid ) or unsaturated (arachidonic acid) fatty acids, with the cytoskeletons of resting and activated human blood platelets was studied. The relative binding of lipid components to the cytoskeleton of activated platelets labeled with palmitic acid is six times higher than that of platelets labeled with human426 . Analysis of lipids associated with isolated cytoskeletons of resting and activated platelets (labeled with palmitic acid ) showed a 30-fold increase in the binding of labeled lipids to the cytoskeletal structures during activation. Both diacylglycerol and human718 were found to be associated with the cytoskeleton of activated platelets. Gel filtration, chromatofocusing, and immunoprecipitation studies demonstrated tight binding of these lipids to alpha-Actinin, alpha-actinin . alpha-Actinin, alpha-actinin is one of the proteins that rapidly becomes associated with the cytoskeleton during human423 ; it is also one of the molecules proposed to act as an actin-membrane linker. The results reported indicate a possible participation of alpha-Actinin, alpha-actinin , human718 , and the phosphoinositide-derived second messenger diacylglycerol in the regulation of cytoskeleton-membrane interactions. Together with the results of others they suggest a possible involvement of the phosphatidylinositol cycle in the assembly of actin filaments and their anchoring to membranes.
| null |
3793_biomrc
|
Title: @entity308 Symptom Severity and XXXX in Healthy and Depressed Adults: A Systematic Review and Meta-Analysis.
BACKGROUND: Depression, depression symptom severity and cardiorespiratory fitness, CRF ( cardiorespiratory fitness, CRF ) are significant predictors of mortality and disability. However, the relationship between the two is unclear. OBJECTIVE: This meta-analysis assessed the relationship between Depression, depression symptom severity and cardiorespiratory fitness, CRF in healthy and depressed adults (aged 18 years and over). SEARCH METHODS: The PubMed, Cochrane Library, Google Scholar and ProQuest databases were browsed for relevant English-language studies published from January 2000 to August 2014. SELECTION CRITERIA: Studies reporting a correlation between a Depression, depression scale and maximum oxygen consumption (VO2peak), as well as studies from the data of which such a correlation could be calculated, were included in this analysis. DATA ANALYSIS: Correlation coefficients (CCs) were converted to Fisher's z values, and the analysis was performed using a random-effects model. Then, summary effects and 95 % confidence intervals (CIs) were converted back to CCs. RESULTS: Sixteen studies (totalling 4039 participants, women, men ) were included in this analysis. A modest correlation between Depression, depression symptom severity and cardiorespiratory fitness, CRF was found (CC -0.16, 95 % CI -0.21 to -0.10), appearing stronger in male participants, women, men (CC - 0.22, 95 % CI -0.26 to -0.18) than in female participants, women, men (CC -0.12, 95 % CI -0.19 to -0.05; p = 0.01). There was no difference in the summary effect between healthy and depressed adults (p = 0.43). Heterogeneity was moderate (I (2) = 33 %; p = 0.09). CONCLUSIONS: Depression, depression symptom severity is inversely correlated with cardiorespiratory fitness, CRF , and this correlation is stronger in participants, women, men than in participants, women, men . Clinical and prognostic implications of the correlation are discussed. These findings should stimulate further research on the effects of treating one variable on the other.
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1748_biomrc
|
Title: XXXX in @entity1 Before and After the Introduction of Conjugate Pneumococcal Vaccines.
OBJECTIVES: To determine whether serotype distribution and antibiotic resistance of S. pneumoniae acute mastoiditis, pneumococcal mastoiditis (AM) in children have changed in the post pneumococcal conjugate vaccines (PCVs) era. METHODS: Medical records of pneumococcal AM cases, in a tertiary Pediatric Hospital were reviewed from 1/1999-12/2014. S. pneumoniae isolates were serotyped using the quellung reaction and tested for antibiotic susceptibility by E-test and for macrolide resistance genes by PCR. RESULTS: Among 334 children with AM, S. pneumoniae was isolated from 89(26.6%) with median age 22 months (IQR: 12-30m). S. pneumoniae was recovered from ear fluid (58%), mastoid specimens (35.2%), and blood (6.8%). Resistance to children14 , erythromycin and clindamycin was 12.4%, 49.4% and 18% respectively. Distribution of pneumococcal serotypes before (1999-2005), after the introduction of PCV7 (2006-2010) and after PCV13 (2011-2014) was found: for the PCV7 serotypes 81%, 25%, 0%, (p<0.0001), for PCV13 additional serotypes 16.3%, 70.8%, 63.6%, (p<0.0001) and for non- children485 serotypes 2.3%, 4.1%, 36.3%, (p=0.0002) respectively. Significant increase was detected for the serotype 19A after PCV7 and this trend was not changed after PCV13 (2.3%, 50%, 50% respectively, p<0.0001). A significant proportion of resistant isolates to children14 (54.5%) and erythromycin (34.8%) were identified as 19A . CONCLUSIONS: After the introduction of PCV7 a significant increase of serotype 19A as well as replacement of PCVs serotypes were identified. After PCV13 the overall proportion of mastoiditis, pneumococcal mastoiditis and the incidence of serotype 19A were not significantly declined. A significant proportion of resistant isolates to children14 and erythromycin are attributed to serotype 19A .
| null |
1752_biomrc
|
Title: Laparoscopic management of organic XXXX : is there a place for frozen section diagnosis?
Only benign ovarian cysts can be treated by laparoscopic surgery. Although clinical examination and the results of pre-operative work-up do make a real contribution in indicating the benign or malignant nature of cysts, only histology can provide the absolute diagnosis. In this context, the goal of this study was to establish whether there is any advantage in performing frozen section during laparoscopic surgical management of organic ovarian cysts . Between January 1989 and March 1996, 228 patients underwent an adnexectomy for an ovarian mass. After the pre-operative work-up and the diagnostic phase of laparoscopy, 26 patients (11.4%) presented with suspected signs of malignancy restricted purely to the ovary. These 26 patients underwent a laparoscopic adnexectomy with extraction of the excised tissues using an endoscopic bag, followed by frozen section. For all these patients the results of the frozen section concluded that the lesion was benign. In every case the definitive histological results confirmed the frozen section findings. This strategy enabled us to avoid laparotomy, especially for the nine post-menopausal patients whose adnexal masses appeared to be complex by ultrasound. These encouraging preliminary results need to be confirmed by a larger series of patients , so as to specify the place of frozen section in the laparoscopic surgical management of organic ovarian cysts .
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3800_biomrc
|
Title: [Treatment of @entity4013 unguium with XXXX : an open study comparing twelve weeks and twenty-four weeks of continuous @entity8974 therapy, and determination of @entity8974 level in the target nails].
The study protocol was approved by the Ethical Committee of Sakai Municipal Hospital. A total of 40 outpatients with tinea unguium of the toenails, fingernails or both took part after giving voluntary written informed consent. Inclusion criteria were suggestive clinical appearance, a positive KOH preparation and an opaqueness of more than 50% of the nail length. The patients received 125 mg Terbinafine, terbinafine once a day. The medication was taken after the evening meal and treatment was continued for 12 weeks. Medication stopped in twenty patients who responded well and a follow-up study was continued for 64 weeks. In the other 20 patients , medication was continued for 24 weeks and the follow-up study continued for 64 weeks. At 4-week intervals, the patients were evaluated for their clinical and mycological statuses and adverse reactions. Clipping of distal nail samples, including any attached subungual tissue, was done using nail clippers at 4-week intervals after cessation of therapy and the level of Terbinafine, terbinafine was measured in the laboratory. No adverse reactions were detected. Tinea unguium of fingernails (1) and the third toes (2) were cured easily in the short term in the 12 week therapy group. One case in the 24 week therapy group was excluded because systemic patients34 therapy was started for bullous pemphigoid at 32 weeks. The results of treatment of big toe Onychomycosis, onychomycosis were compared between the 12 week (17) and the 24 week (19). In the former group, 9 (52.9%) showed complete cure and 8 (47.1%) showed relapse or worse after cessation of therapy was. In 24 week therapy group, complete cure was achieved in 14 (73.7%) and relapse or worse in 5 (26.3%). The cure rate between the 2 groups was statistically not significant. Terbinafine, terbinafine was detected in the target nails up to 24 weeks after cessation of medication in both groups. Onychomycosis, onychomycosis or tinea pedis reappeared in a few cases 12 to 16 weeks after medication ceased in the 12 week group. Topical antimycological therapy is necessary after cessation of oral Terbinafine, terbinafine .
| null |
3806_biomrc
|
Title: Variation of current protocols for managing out-of-hospital XXXX in prehospital settings among Asian countries.
BACKGROUND/PURPOSE: Protocols for managing patients with out-of-hospital patients167 (OHCA) may vary due to legal, cultural, or socioeconomic concerns. We sought to assess international variation in policies and protocols related to OHCA. METHODS: A brief survey was developed by consensus. Elicited information included protocols for managing patients with nontraumatic OHCA or traumatic OHCA, policies for using AEDs, automated external defibrillators ( AEDs, automated external defibrillators ) during transportation of patients with ongoing resuscitation, and application of terminations of resuscitation (TOR) rules in prehospital settings in the respondent's city or country. The populations of interest were emergency physicians, medical directors of emergency medical services (EMS), and policy makers. RESULTS: Responses were obtained from eight cities in six Asian countries. Only one (12.5%) city applied TOR rules for OHCAs. Do-not-resuscitate (DNR) orders were valid in prehospital settings in five (62.5%) cities. All cities used AEDs, automated external defibrillators for nontraumatic OHCAs; seven (87.5%) cities did not routinely use AEDs, automated external defibrillators for traumatic OHCAs. For nontraumatic OHCAs, four (50%) cities performed 2 minutes of on-scene cardiopulmonary resuscitation (CPR) and then transported the patients with ongoing resuscitation to hospitals; three (37.5%) cities performed 4 minutes of on-scene CPR; one (12.5%) city allowed variation in the duration of on-scene CPR. CONCLUSION: International variation in practices and polices related to OHCAs do exist. Concerns regarding prehospital TOR rules include medical evidence, legal considerations, EMS manpower, public perception, medical oversight, education, EMS characteristics, and cost-effectiveness analysis. Further research is needed to achieve consensus regarding management protocols, especially for EMS that perform resuscitation during transportation of OHCA patients .
| null |
1761_biomrc
|
Title: Radiotherapy alone or in combination with surgery in the management of XXXX .
239 women, Patients, patients with tumor, stage III carcinoma of the breast were treated by primary radiation therapy from 1977 to 1985. Of them 212 had an objective response and 27 showed no response to irradiation. From the objective responders, 105 women, Patients, patients were subjected to mastectomy and axillary dissection and in 107 cases the radiotherapy was not followed by surgery. women, Patients, patients of operated group had a 71% and the RT alone group had a 61% local-regional tumor, stage III carcinoma control at 5 years. The analysis of local-regional recurrences revealed that none of the operated women, Patients, patients had axillary recurrence but 8 had in the RT alone group. Postirradiation surgery is recommended for women, Patients, patients who have residual disease especially in the axillary region. The 5-year survival rate of operated women, Patients, patients was significantly better, 58% vs. 35%. However, these results are not comparable since the incidence of less favourable cases was higher in the RT alone group. Chemotherapy was initiated for the 27 women, Patients, patients who failed to respond to RT, but results were unsatisfactory. None of them survived three years. Further studies are needed to explore the role of chemotherapy in this stage of breast cancer .
| null |
3809_biomrc
|
Title: Treatment with @entity2226 , @entity3988 , and XXXX retards the progressive visual field @entity6391 : a 3-year follow-up study.
The purpose of this study to assess the effect of the formula taurine / diltiazem / vitamin E on the progression of visual field loss in retinitis pigmentosa . A double blind, placebo controlled study in 62 patients : visual field threshold values were obtained in a Humphrey Field Analyzer from center (30 degrees) and periphery (30-60 degrees), every 4 months during 3-year follow-up. Data were analyzed by univariate regression, with slopes obtained from the best fit lines. Based on slope values, three groups of patients were identified as those showing negative, positive, or zero slope: > or = 1 to < or = +1. In controls (32 patients ), at central area, the distribution in negative, zero, or positive slope was, respectively, 16 (50%), 11 (35%), and 5 (15%). In the treated group (30 patients ) this distribution was 6 (20%) negative, 17 (53%) zero, and 7 (23%) positive slope. In periphery, 16 control patients were distributed as 11 (69%) negative, 4 (25%) zero, and 1 (6%) positive slope. In the treated group (17 patients ), the distribution was opposite: 1 (6%) negative, 7 (41%) zero, and 9 (53%) positive slope. Nineteen patients receiving treatment up to 6 years showed similar distribution by slope values. Eight out of 9 patients switched from placebo (2 years) to treatment (2-3 years), showed improving changes in their slope values. A beneficial effect of the treatment decreasing the rate of visual field loss was observed, likely through a protective action from free radical reactions in affected photoreceptors.
| null |
3810_biomrc
|
Title: Bacille Calmette-Gu rin XXXX .
BACKGROUND: Tuberculosis, tuberculosis is an essential problem for healthcare systems especially in developing countries. All newborns are given Bacillus Calmette-Gu rin (BCG) vaccine in Iran which is prepared from live bovine Tuberculosis, tuberculosis bacillus, and is given to protect against Tuberculosis, tuberculosis . Osteomyelitis, osteomyelitis secondary to BCG vaccination is rare and usually involves epiphysis of long tubular bones. METHODS: 4 child, children, patients , 3 males and a female entered this study and were between 11 to 24 months old. The involved bones were first metatarsi, talus, humerus and tibia bone. The main radiologic finding was lytic lesion with cortical destruction and periosteal reaction. RESULTS: 3 child, children, patients underwent core needle biopsy and the one with the proximal tibia involvement, underwent open surgery. Pathology report suggested granulomatous osteomyelitis and typical caseous necrosis compatible with Tuberculosis, tuberculosis . Surgical treatment for these child, children, patients was curettage and debridement of the bone lesion and involved tissues around. The child, children, patients got standard anti TB pharmacotherapy, were completely cured and no short term complication was seen in a one year follow up. CONCLUSION: BCG Osteomyelitis, osteomyelitis and cold abscess , should be kept in mind when assessing a child, children, patients presenting chronic symptoms like child, children, patients58 , limping or local swelling of extremities. The long interval time between BCG vaccination and outbreak of the culture-negative abscess is a major point which emphasizes on pathologic evaluation. Image guided tissue biopsy and PCR studies confirm diagnosis. Early use of a surgical curettage and debridement along with chemotherapy soon afterwards, enabled these child, children, patients to enjoy a satisfactory clinical outcome.
| null |
1762_biomrc
|
Title: XXXX , @entity4446 and birth outcome: a population-based cohort study.
BACKGROUND: Data on the safety of azathioprine and mercaptopurine during pregnancy are very sparse. AIM: To examine the risk of adverse birth outcomes in women, children who took up prescriptions for azathioprine or mercaptopurine during pregnancy. METHODS: This is a Danish cohort study based on data from a population-based prescription registry, the Danish Birth Registry and the Hospital Discharge Registry. To examine the risk of congenital malformations , we included nine pregnancies exposed 30 days before conception or during the first trimester. To examine perinatal mortality, pre-term birth and low birth weight, we included 10 pregnancies exposed during the entire pregnancy. Eleven different exposed women, children were included in the study. Outcomes were compared with those of 19 418 pregnancies in which no drugs were prescribed to the mothers. RESULTS: Fifty-five per cent of the exposed women, children had inflammatory bowel disease and 45% other diseases. Adjusted odds ratios for congenital malformations , perinatal mortality, pre-term birth and low birth weight were 6.7 (95% confidence interval, 1.4-32.4), 20.0 (2.5-161.4), 6.6 (1.7-25.9) and 3.8 (0.4-33.3), respectively. CONCLUSIONS: Our results suggest that there is an increased risk of congenital malformations , perinatal mortality and pre-term birth in women, children born to women, children treated with azathioprine or mercaptopurine during pregnancy. More data are needed to determine whether the associations are causal or occur through confounding.
| null |
3816_biomrc
|
Title: Novel evidence of microglial immune response in impairment of XXXX of CNS.
UNASSIGNED: Dengue, the most rampant zoonotic viral disease in tropics, contributes to 14% of acute febrile illness cases globally. encephalitis, Encephalitis in primary Dengue fever , with/without haemorrhage has been reported occasionally. Our study presents novel evidence for this rarity at the molecular level. Murine microglia (BV2) were infected in-vitro with Dengue virus (DENV) serotypes (1-4) and their immune response was evaluated. Gene expressions of TNF-a , IL-10 , IFN-y, and IL1-b constituted the pro-inflammatory response, levels of MCP-1 and IL-6 represented the regulatory mechanism and changes in the levels of Occludin , MMP-2 , MMP-9 and TIMP-1 encompassed the break-down of the blood-brain barrier (BBB). Cytokine response was studied using RT-PCR, with relative fold change assessed using Ct method. We observed that DENV1 increased vascular permeability and trans-membrane transport, while DENV2 resulted in oxidative stress. DENV3 Dengue infection, infection presented with impaired immune response and DENV4 manifested a chaotropic response of the BBB protein genes. However, no serotype was able to breakdown the BBB, thus validating the low prevalence of encephalitis, Encephalitis in dengue. Our study is the first reported evidence of the microglial immune response resisting the entry of DENV into the CNS. It also supports the theory that primary Dengue infection, infection results in the acute inflammation of the microglia, and the host immune response plays a critical role in development of encephalitis, Encephalitis .
| null |
3817_biomrc
|
Title: Molecular biology and neurobiology of XXXX acetyltransferase.
In the 45 years since the first description of choline acetyltransferase ( ChAT ; EC 2.3.1.6.), significant progress has been made in characterizing the molecular properties of this important neurotransmitter synthetic enzyme. We are now on the verge of understanding its genetic regulation and biological function(s). The Drosophila cDNA has been cloned, sequenced, and expressed in both a eucaryotic and a procaryotic system. The levels of ChAT specific mRNA have been determined during Drosophila development. Monoclonal and polyclonal antibodies have been produced to the enzyme from a variety of sources and used for biochemical and immunocytochemical studies. Two well characterized genetic systems have identified the ChAT gene and described a series of useful alleles. As a nervous system specific protein expressed only in the subset of neurons using acetylcholine as a neurotransmitter, ChAT is a good model for uncovering the processes and factors responsible for regulating genes involved in neurotransmitter phenotype selection and maintenance. Recent studies have described the purification of a cholinergic factor from muscle conditioned medium and indicated the potential importance of nerve growth factor (NGF) for regulating ChAT expression in the central nervous system. These factors, or ones remaining to be discovered, may be involved in the etiology or disease process of neurodegenerative nervous system disorders such as "Alzheimers disease" .
| null |
3821_biomrc
|
Title: Prognosis of benign childhood @entity302 with centrotemporal spikes: a follow-up study of 168 XXXX .
A spontaneous and complete recovery of benign childhood epilepsy with centrotemporal or rolandic spikes (BECT) is taken for granted. However, some authors have reported the occurrence of generalized seizure, seizures, tonic-clonic seizures in a few adult children, patients and in some children, patients who have seizure, seizures, tonic-clonic seizures after a long period without problems. The aims of this study were (a) to search for early predictors of outcome and (b) to ascertain the long-term prognosis of BECT in a large group of children, patients . An attempt to relocate 268 children, patients born between 1941 and 1967 and consecutively seen as outpatients was undertaken. The outcome after age 20 is known for only 168. Being adults and cured, the others are no longer in touch with their clinics or have moved. Only one indicator of short-term prognosis was found: The earlier the onset of BECT, the longer the period with seizure, seizures, tonic-clonic seizures . Of the 168 children, patients , 165 are seizure, seizures, tonic-clonic seizures -free with follow-up ranging from 7 to 30 years. Three children, patients experienced generalized seizure, seizures, tonic-clonic seizures at age 18, 22-24, and 35. Two apparently had an isolated seizure, seizures, tonic-clonic seizures . The occurrence of such seizure, seizures, tonic-clonic seizures after recovery from BECT is a rare event (approximately 2% of cases) and a relapse with partial seizure, seizures, tonic-clonic seizures is quite uncommon. These children, patients do not differ from children, patients remaining seizure, seizures, tonic-clonic seizures -free.
| null |
3823_biomrc
|
Title: Ascending XXXX after percutaneous vertebroplasty.
Background Context. Cement leakage is not a rare complication of vertebroplasty, but ascending tonic clonic seizure syndrome is exceptionally rare. We herein report the first case to our knowledge of this complication related to vertebroplasty. Purpose. We herein report the first case of ascending tonic clonic seizure syndrome following epidural cement leakage after percutaneous vertebroplasty in a woman, patient with multiple osteoporotic compression fractures . Study Design. CASE REPORT: Methods. A 64-year-old woman, patient with T8, T10, L2, and L4 osteoporotic compression fractures underwent percutaneous vertebroplasty using polymethylmethacrylate. 40 minutes after the procedure the woman, patient started suffering back and leg woman, patient58 , having repetitive myoclonic jerks lasting 15 seconds of the lower extremities, spasm of the back, dyspnea , sinus tachycardia , hypoxemia , and metabolic acidosis . Results. The woman, patient recovered completely due to a combination of early effective resuscitation and considered definitive management. Conclusions. Percutaneous vertebroplasty with polymethylmethacrylate is relatively safe but has few dangerous complications, which should be prevented by a meticulous technique and excellent image quality.
| null |
3824_biomrc
|
Title: Changes in lipid metabolism and extension of XXXX .
BACKGROUND/AIMS: patients150 ( patients150 ) and patients151 ( patients151 ) are common diseases with a vast number of acquired and congenital risk factors. Disorders of the lipid metabolism are not established risk factors for patients211 ( patients211 ) so far. However, in recent literature, associations between patients211 and the metabolic syndrome , especially with elevated lipid parameters, have been described. The aim of our study was to investigate the association between the extension of patients211 and changes in the lipid profile. METHODS: We included 178 patients211 patients in our study; 59 patients had isolated patients151 , 39 patients had isolated patients150 of the leg and 80 patients had both ( patients150 and patients151 ). Concerning patients151 , we distinguished between massive and submassive patients151 . We evaluated plasma lipids and lipoproteins in patients151 and patients150 patients as well as in massive and submassive patients151 patients . RESULTS: patients151 patients had higher levels of plasma patients674 [median (interquartile range): 162 (109-254) vs. 136.5 (96.5-162) mg/dl, p = 0.047] and lower levels of high-density lipoprotein patients65 (HDL-C; 52.1 17.2 vs. 63.9 22.7 mg/dl, p = 0.004) than patients150 patients . Furthermore, patients151 patients were significantly older than patients150 patients (59.6 16.9 vs. 52.2 15.5 years, p = 0.02). We were not able to find differences in lipid parameters in patients with massive patients151 compared to those with submassive patients151 . However, patients with massive patients151 were more obese than patients with submassive patients151 (body mass index 29.1 4.6 vs. 26.9 4.9, p = 0.012). CONCLUSIONS: Lipid parameters and lipoproteins differ between patients150 and patients151 patients . patients151 patients had higher triglyceride and lower HDL-C levels compared with patients150 patients .
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1784_biomrc
|
Title: Percutaneous management of XXXX associated with @entity1333 : a single center experience.
The purpose of this study was to evaluate the safety and effectiveness of percutaneous transluminal angioplasty for occlusive arterial disease, occlusive lesions associated with women, patients, man333 . Eleven women, patients, man (10 women, patients, man , 1 women, patients, man ; ages 35-82 years) with the diagnosis of women, patients, man333 of the large vessels underwent interventional treatment during intraarterial angiography. The causes included giant cell arteritis (n = 8) and women, patients, man2040 (n = 3). Thirty-three occlusive arterial disease, occlusive lesions (including brachiocephalic and renal arteries, and arteries of upper and lower extremities) were treated with balloon angioplasty and/or stent placement. Follow-up included clinical examination, angiography, and color duplex ultrasound. Technical success was 100% (25/25) for stenoses and 50% (4/8) for occlusive arterial disease, occlusive lesions , representing all lesions combined from different anatomic locations. Dissection (n = 3) and arterial rupture with retroperitoneal women, patients, man410 (n = 1) was found in three women, patients, man . During follow-up (mean 12 months), restenoses (n = 8) and re-restenoses (n = 1) occurred in 8 vascular areas. Three of these lesions were treated with repeated PTA (n = 4). The cumulative primary clinical success rate was 67.6%, cumulative secondary success rate 74.4%, and cumulative tertiary success rate 75.9%. Interventional therapy in systemic women, patients, man333 provides promising results in technical success rates and followup. Angioplasty may result in women, patients, man317 , but the rate of complications is low.
| null |
1787_biomrc
|
Title: [Is the use of @entity632 ( XXXX ) limited by its @entity1370 ?].
Adriamycin, doxorubicin ( Adriamycin, doxorubicin ), one of the most active cytotoxic antineoplastic agents, can cause heart failure . This side effect is dose-dependent, the frequency of heart failure being 3% at a cumulative Adriamycin, doxorubicin dose of 400 mg/m2 and 18% at 700 mg/m2. It is assumed that Adriamycin, doxorubicin , or other anthracycline derivatives, are still active when the patients370 level is reached. In this retrospective study of 171 patients with various metastatic malignant tumors , the total dose of Adriamycin, doxorubicin given to the patients and the reasons for withholding the treatment have been analyzed. Overall, among the 171 patients treated by Adriamycin, doxorubicin -containing combination chemotherapy, 54 objective remissions (31%) were observed. Remissions were more frequent in untreated patients (52%) than in previously treated patients (20%). In 36 of 54 patients the disease progressed before the cumulative patients370 level was reached. Adriamycin, doxorubicin could be discontinued in only 18 patients still in remission. 8 of 171 patients received more than 450 mg/m2 Adriamycin, doxorubicin without patients370 side effects being observed. Among the 171 patients , patients370 probably related to anthracyclines developed in 5 cases (3%), in all cases at a level below 450 mg/m2. These results suggest that in most cases Adriamycin, doxorubicin becomes inactive before the dose-limiting cumulative patients370 level is reached.
| null |
3839_biomrc
|
Title: A @entity1 @entity10734 expressed in XXXX stimulates proliferation and differentiation of hemopoietic progenitors to all lineages in response to @entity1 @entity2841 .
GM-CSF, Granulocyte-macrophage colony-stimulating factor ( GM-CSF, Granulocyte-macrophage colony-stimulating factor ) mainly stimulates proliferation and maturation of myeloid progenitor cells. Although the signal transduction pathways triggered by human0734 ( human0734 ) have been extensively characterized, the roles of human0734 signals in differentiation have remained to be elucidated. To examine the relationship between receptor expression and differentiation of hemopoietic cells, we used human9 (Tg- human9 ) that constitutively express human (h) human0734 at almost all stages of hemopoietic cell development. Proliferation and differentiation of hemopoietic progenitors in bone marrow cells from these Tg- human9 were analyzed by methylcellulose colony formation assay. High affinity human0734 interacts with GM-CSF, Granulocyte-macrophage colony-stimulating factor in a species-specific manner, therefore one can analyze the effects of hGMR signals on differentiation of human9 hemopoietic progenitors using hGM-CSF . Although human9 (m) GM-CSF, Granulocyte-macrophage colony-stimulating factor yielded only GM colonies, hGM-CSF supported various types of colonies including GM, eosinophil, mast cell, erythrocyte, megakaryocyte, blast cell, and mixed hemopoietic colonies. Thus, the effects of hGM-CSF on colony formation more closely resembled mIL-3 than those of mGM-CSF. In addition, hGM-CSF generated a much larger number of blast cell colonies and mixed cell colonies than did mIL-3 . hGM-CSF also generated erythrocyte colonies in the absence of human4190 . Therefore, GM-CSF, Granulocyte-macrophage colony-stimulating factor apparently has the capacity to promote growth of cells of almost all hemopoietic cell lineages, if functional hGMR is present.
| null |
1791_biomrc
|
Title: The XXXX metR gene encodes a bZIP protein which activates transcription of sulphur metabolism genes.
The identification, isolation and characterization of a new Aspergillus nidulans positive-acting gene metR, which encodes a transcriptional activator of sulphur metabolism, is reported. metR mutants are tight auxotrophs requiring methionine or homocysteine for growth. Mutations in the metR gene are epistatic to mutations in the negative-acting sulphur regulatory scon genes. The metR coding sequence is interrupted by a single intron of 492 bp which is unusually long for fungi. Aspergillus nidulans METR is a member of bZIP family of DNA-binding proteins. The bZIP domains of METR and the Neurospora, Neurospora crassa CYS3 transcriptional activator of sulphur genes are highly similar. Although Neurospora, Neurospora crassa cys-3 gene does not substitute for the metR function, a chimeric metR gene with a cys-3 bZIP domain is able to transform the DeltametR mutant to methionine prototrophy. This indicates that METR recognizes the same regulatory sequence as CYS3. The metR gene is not essential, as deletion mutants are viable and have similar phenotype as point mutants. In contrast to the Neurospora, Neurospora crassa cys-3, transcription of the metR gene was found to be regulated neither by METR protein nor by sulphur source. Transcription of metR gene is derepressed in the sconB2 mutant. Transcription of genes encoding sulphate permease, homocysteine synthase, cysteine synthase, ATP -sulphurylase, and sulphur controller--sconB is strongly regulated by the metR gene product and depends on the character of the metR mutation and sulphur supplementation.
| null |
1792_biomrc
|
Title: Independently Controlled Wing Stroke Patterns in the @entity238 XXXX .
Flies achieve supreme flight maneuverability through a small set of miniscule steering muscles attached to the wing base. The fast flight maneuvers arise from precisely timed activation of the steering muscles and the resulting subtle modulation of the wing stroke deformations, stroke, elementary deformations of the wing stroke . In addition, slower modulation of wing kinematics arises from changes in the activity of indirect flight muscles in the thorax. We investigated if these modulations can be described as a superposition of a limited number of stroke deformations, stroke, elementary deformations of the wing stroke that are under independent physiological control. Using a high-speed computer vision system, we recorded the wing motion of tethered flying fruit flies for up to 12 000 consecutive wing strokes at a sampling rate of 6250 Hz. We then decomposed the joint motion pattern of both wings into components that had the minimal mutual information (a measure of statistical dependence). In 100 flight segments measured from 10 individual flies, we identified 7 distinct types of frequently occurring least-dependent components, each defining a kinematic pattern (a specific deformation of the wing stroke deformations, stroke, elementary deformations of the wing stroke and the sequence of its activation from cycle to cycle). Two of these stroke deformations, stroke, elementary deformations of the wing stroke can be associated with the control of yaw torque and total flight force, respectively. A third deformation involves a change in the downstroke-to-upstroke duration ratio, which is expected to alter the pitch torque. A fourth kinematic pattern consists in the alteration of stroke deformations, stroke, elementary deformations of the wing stroke amplitude with a period of 2 wingbeat cycles, extending for dozens of cycles. Our analysis indicates that these four elementary kinematic patterns can be activated mutually independently, and occur both in isolation and in linear superposition. The results strengthen the available evidence for independent control of yaw torque, pitch torque, and total flight force. Our computational method facilitates systematic identification of novel patterns in large kinematic datasets.
| null |
3845_biomrc
|
Title: Effect of diuretics on allergen-induced contractions of passively sensitized XXXX bronchi in vitro.
Inhaled Human483 has been shown to protect subjects with asthma from bronchoconstriction induced by a wide variety of stimuli, including allergen, but the mechanism of action is controversial. We have used an in vitro model of allergen-induced bronchoconstriction to examine the effects of Human483 and other ion transport inhibitors. Human bronchial rings were passively sensitized by incubation with serum from an atopic donor and were challenged with Dermatophagoides pteronyssinus . Allergen-challenged bronchial rings developed bronchoconstriction which was effectively inhibited by the cysteinyl-leukotriene antagonist ICI 198,615 (10(-7) M) and to a lesser extent by terfenadine (10(-5) M). Assessed over 60 min Human483 10(-6), 10(-5), and 10(-4) M inhibited contractions by a mean (95% confidence interval [CI]) 7.9% (-23.5, 39.3%, p > 0.05), 44.2% (12.9, 75.2%, p < 0.01), and 86.9% (55.5, 118.3%, p < 0.001) respectively (n = 5). The same concentrations of Human1623 inhibited contractions by 21.5% (-8.4, 51.4%, p > 0.05), 13.6% (-16.3, 43.4%, p > 0.05) and 51.6% (21.7, 81.4%, p < 0.01) respectively (n = 5). The Human372 transport inhibitor amiloride and the anion transport inhibitor Human8850 ( Human8850 ) were without effect (both 10(-4) M; n = 4). Human483 increased Human421 production by the bronchial rings by 134% (95% CI 53, 259%). Indomethacin (3 x 10(-6) M) blocked the Human483 -induced increase in Human421 production and reduced the protection afforded by 10(-4) M Human483 against allergen-induced contractions from 67.9% to 34.7% (mean difference 33.2%; 95% CI 9.7, 56.6%; p < 0.01; n = 8).(ABSTRACT TRUNCATED AT 250 WORDS)
| null |
1799_biomrc
|
Title: Tissue inhibitor of metalloproteinase-I and interstitial collagenase expression in XXXX and activated @entity1 hepatic lipocytes.
1. Activated hepatic lipocytes are central to the pathogenesis of liver fibrosis as the principal source of both interstitial collagens and matrix-degrading metalloproteinases. In progressive fibrosis there is a failure to degrade interstitial collagens with a reported decrease in collagenase activity. In these studies we investigate expression of the potent collagenase inhibitor, tissue inhibitor of metalloproteinase-1, and interstitial collagenase in end-stage autoimmune chronic active hepatitis and activated human hepatic lipocytes in culture. 2. Messenger RNA transcripts for interstitial collagenase and tissue inhibitor of metalloproteinase-1 in explanted human liver were quantified by ribonuclease protection assay and densitometric analysis. This indicated that tissue inhibitor of metalloproteinase-1 and interstitial collagenase expression in autoimmune chronic active hepatitis were also coordinately up-regulated. 3. Using Northern analysis of RNA from human lipocytes in primary culture on plastic, mRNA for interstitial collagenase could not be detected in unstimulated cells but was present after stimulation with tumour necrosis factor alpha. Tissue inhibitor of metalloproteinase-1 mRNA was present in unstimulated lipocytes and up-regulated fivefold in response to tumour necrosis factor alpha. Using activity assay of serum-free conditioned media, interstitial collagenase could not be detected in unstimulated primary cultures, primary cultures stimulated with tumour necrosis factor alpha or transforming growth factor beta-1 (n = 3 and n = 4 respectively) or in passaged lipocytes (n = 6). In contrast, free tissue inhibitor of metalloproteinase-1 activity was present in unstimulated and passaged cultures and this was increased in response to tumour necrosis factor alpha and transforming growth factor beta-1 .(ABSTRACT TRUNCATED AT 250 WORDS)
| null |
3851_biomrc
|
Title: Ontogenetic changes in the pattern of XXXX accumulation in song-control nuclei of male zebra finches.
The present study examines the development of androgen accumulation in cells of two brain nuclei that are involved in controlling vocal behavior in zebra finches ( MAN2128 ). HVc (caudal nucleus of the ventral hyperstriatum) is involved with vocal production in adult birds, and MAN (magnocellular nucleus of the anterior neostriatum) is involved with the initial ability to learn song. In both of these nuclei there is an increase in the proportion of cells that are labeled by systemic injections of tritiated dihydrotestosterone in juvenile male zebra finches during the time when production of song is becoming stereotyped (25-60 days). Within MAN there is an overall loss of cells during this time, such that the absolute number of androgen target cells in MAN remains at a constant level. However, it does not appear to be the case that unlabeled cells are selectively lost from MAN . Rather it appears that both labeled and unlabeled cells are lost, and the absolute number of labeled cells is maintained at a constant level via recruitment of additional labeled cells from the unlabeled population (i.e., some MAN cells that are unlabeled in young birds become labeled in older birds). In line with this hypothesis, there is a large increase in the density of labeling in individual MAN cells, indicating that these cells have an enhanced ability to concentrate androgen . In contrast to the situation in MAN , there is an increase in the overall number of cells within HVc during this time; this increase in total cell number combines with the increased proportion of labeled cells such that the absolute number of androgen target cells in HVc increases threefold. The ability of individual HVc cells to accumulate androgen remains constant. The relationship of these changes in the pattern of androgen accumulation to other aspects of neural and behavioral development related to song in zebra finches are discussed.
| null |
1804_biomrc
|
Title: The accuracy of the CGMS in @entity1 with type 1 @entity6 : results of the @entity6 in XXXX network (DirecNet) accuracy study.
The accuracy of the Continuous glucose, Glucose Monitoring System, CGMS (Medtronic MiniMed, Northridge, CA) was assessed in children and adolescents with type 1 diabetes mellitus, T1DM, diabetes ( type 1 diabetes mellitus, T1DM, diabetes ) when compared with reference serum glucose, Glucose levels during spontaneous fluctuations in glucose, Glucose levels over 24 h and during acute hyper- and hypoglycemia . Ninety-one subjects with type 1 type 1 diabetes mellitus, T1DM, diabetes (3.5-17.7 years old) wore one or two CGMSs while blood samples were obtained for serum glucose, Glucose determinations (made at a central laboratory) hourly during the day, every 30 min overnight, and every 5 min during meal-induced hyperglycemia and insulin-induced hypoglycemia tests, resulting in 6778 CGMS-reference glucose, Glucose pairs. CGMS function was assessed on each of the 3 days of sensor life. The median relative absolute difference (RAD) between the CGMS and reference values was 18% (25th, 75th percentiles = 8%, 34%). Similar results were obtained on each of the 3 days of sensor life. Accuracy was worse during hypoglycemia than during hyperglycemia . Modified sensors that first became available in November 2002 were more accurate than were the original sensors (median RAD = 11% vs. 19%) and had better precision (r = 0.92 vs. r = 0.77) during time periods in which two CGMSs were simultaneously used. The CGMS sensors that have been in clinical use until recently are often inaccurate in quantifying glucose, Glucose values in children with type 1 diabetes mellitus, T1DM, diabetes . However, recent modifications to the sensor have resulted in substantially better accuracy and reliability. This improved function, if confirmed by additional data, may enhance the clinical utility of the CGMS.
| null |
3854_biomrc
|
Title: Effect of non-surgical periodontal treatment on glycemic control of @entity1 with XXXX : a meta-analysis of randomized controlled trials.
OBJECTIVE: The present study aimed at investigating whether non-surgical periodontal treatment can reduce the Haemoglobin A1c (HbA1c) % level in patients64 2 diabetic, diabetes patients . METHODS: A search of the literature on English publications was performed in Cochrane Central, Medline, ISI Web of Knowledge and EMBASE (until 06 February 2014). An RCT was selected if the subject was patients64 2 diabetic, diabetes patients diagnosed with chronic periodontitis , and compared HbA1c% change after non-surgical periodontal treatment alone for at least three months of the study duration. Weighted mean difference for pooled data and large sample size strata were calculated. Heterogeneity and publication bias were explored. RESULTS: After the study selection process, only 9 RCTs were suitable. Compared to the control group, the pooled analysis (n=1082) showed -0.27 % (95 % CI:-0.46 % to -0.07 %, p= 0.007) absolute difference in HbA1c % with treatment while studies with sufficient sample size had HbA1c % change of -0.014 % (95 % CI:-0.18 % to 0.16 %, p= 0.87). Publication bias was marginally significant with Egger's teat (p=0.045) but not with Begg's test (p=0.72). CONCLUSION: The moderate reduction in HbA1c after the non-surgical therapy in patients with patients64 2 diabetic, diabetes is consistent with previous systematic reviews. However, more large scale and high-quality RCTs are necessitated to confirm these results.
| null |
1814_biomrc
|
Title: @entity3009 -independent protection by @entity1483 from oliguric @entity177 in conscious XXXX .
In 38 conscious rats divided into seven groups, acute unilateral oliguric renal failure, ischemic renal failure was induced by 1 hour of renal artery occlusion, complete occlusion of the left renal artery while the contralateral kidney remained intact. Renal excretory function of the left kidney was monitored up to 144 hours after ischemia, ischemic and revealed a typical course of oliguric renal failure, ischemic renal failure with oligoanuria persisting for more than 48 hours. Urinary osmolality and sodium concentration became plasma isotonic after release of renal artery occlusion, complete occlusion of the left renal artery and approximated control values on day 6 after ischemia, ischemic . In nine rats , the i.v. infusion of furosemide before (6 microgram/min/100 g body wt) and after (12 microgram/min/100 g body wt) renal artery occlusion, complete occlusion of the left renal artery protected the ischemia, ischemic kidney from oligoanuria with endogenous creatinine clearance of 0.42 +/- 0.11 ml/min/g kidney wt 5 hours after ischemia, ischemic . Tubular absorption of sodium and water was at least partially preserved 36 hours after ischemia, ischemic when infusion of furosemide was stopped. The loop diuretic significantly (P less than 0.01) increased total urinary prostaglandin (PG) E2 excretion before and after renal artery occlusion, complete occlusion of the left renal artery ; and 5 hours after ischemia, ischemic , PGE2 excretion from the ischemia, ischemic kidney significantly exceeded that from the intact kidney (P less than 0.05). Indomethacin (1 mg/100 g body wt) administered in six animals markedly suppressed control PGE2 excretion (P less than 0.05) as well as the furosemide -induced rise in urinary PG excretion before and after ischemia, ischemic but did not modify the protective effect of the diuretic in this experimental model. Inhibition of PG synthesis, however, reduced urinary flow rate and sodium and potassium excretion of the contralateral intact kidney and almost completely prevented its compensatory rise in creatinine clearance. The results indicate that mechanisms other than the intrarenal prostaglandin system must be considered to mediate the protective effects of furosemide in acute oliguric renal failure, ischemic renal failure .
| null |
1815_biomrc
|
Title: [ XXXX : comparative analysis of epidemiological data of French and North American registries].
A national registry for patients577 was established in France in 1993. A questionnaire is sent once a year to different health care units. The first questionnaire was analyzed in 1992: 1,893 patients (53% males) were identified. 28% were over 15 years of age, 13% more than 20, and 1% over 35. Usually, diagnosis had been suggested by respiratory signs, followed by digestive tract signs and growth impairment and meconial ileus. 13% were diagnosed in screening programmes. Diagnosis was made before 1 year in 66% of the subjects (mean = 7 months). All the data collected and the functional and bacteriologic data were compared with those observed in the United States and Canada. It should also be noted that 38 patients were grafted during this study year and that it is too early to analyze the general outcome for all subjects. The creation of this registry is an important step towards a better understanding of the epidemiology of patients577 in the French population.
| null |
1818_biomrc
|
Title: American Association for the Surgery of @entity130 Scale for kidney @entity130 predicts nephrectomy, dialysis, and death in XXXX with @entity1913 and nephrectomy for penetrating @entity130 .
BACKGROUND: Despite broad clinical use of the American Association of the Surgery of patients, patient30 (AAST) injury scale for kidney, it has only been found to predict the need for renal surgery in single institution series. We sought to validate this scheme for morbidity and mortality in a national cohort of patients, patient with kidney injury, Renal injury, renal injury . METHODS: A retrospective cohort design was used to determine the association between increasing AAST scores and nephrectomy, dialysis, and mortality. The cohort included all patients, patient with a kidney injury, Renal injury, renal injury in the National patients, patient30 Data Bank (NTDB) from 1994 and 2003. Univariate and multivariate prediction models were used for analysis of data. RESULTS: At the time of review, a total of 742,774 patients, patient records were registered in the NTDB. kidney injury, Renal injury, renal injury occurred in 8465 patients, patient (1.2%). Increasing injury grade was associated with a greater nephrectomy (RR 12-127), dialysis (RR 1.3-4.7), and mortality (RR 1.3-1.9) rate for blunt kidney injury, Renal injury, renal injury . For penetrating injury, nephrectomy was the only outcome that was associated with higher grades of kidney injury, Renal injury, renal injury with a RR of 7.7 to 31 for grades III to V patients, patient30 . CONCLUSION: The AAST injury scale for kidney predicts for morbidity in blunt and penetrating kidney injury, Renal injury, renal injury and for mortality in patients, patient913 . Thus, we continue to support its use as a clinical and research tool.
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1821_biomrc
|
Title: Extra-anatomic revascularization for preoperative @entity1779 due to distal carotid artery occlusion in XXXX .
OBJECTIVES: Management of patients, patient with AADA, acute aortic dissection type A ( AADA, acute aortic dissection type A ) and patients, patient779 secondary to occlusion or stenosis of the left common carotid artery (LCCA) or right common carotid artery (RCCA) is a significant challenge. The aim of this study is to present our institutional strategy and postoperative results for this high-risk patients, patient cohort. METHODS: Between November 2005 and July 2013, 23 of 354 consecutively operated AADA, acute aortic dissection type A patients, patient [median age: 66.3; interquartile range (IQR): 55.2-69.9] suffered from patients, patient779 due to bilateral (n = 1) or unilateral occlusion of the LCCA/RCCA (n = 22). AADA, acute aortic dissection type A repair comprised hemi- (n = 14) or total (n = 9) arch replacement in combination with aortic valve repair (n = 7) or replacement (n = 11), root replacement (n = 15) and coronary bypass (n = 3). Extra-anatomic aorto-carotid bypass was performed in all patients, patient . Aorto-carotid bypass was performed at the beginning of the procedure to allow for unilateral selective cerebral perfusion (n = 17; 73.9%) or during the procedure if persisting malperfusion was suspected by near-infrared spectroscopy (n = 6; 26.1%). RESULTS: The median follow-up was 15.2 months (IQR: 4.8-34.1) and 100% complete. Median hospital stay and ICU stay were 16.0 (IQR: 12.5-26.0) and 13.7 (IQR: 2.0-16.5) days, respectively. Rethoracotomy for haemorrhage or cardiac tamponade was performed in 6 (26.1%) patients, patient . Other postoperative complications comprised low cardiac output with extracorporeal membrane oxygenation (n = 2; 8.7%), sepsis (n = 4; 17.4%), patients, patient576 (n = 10; 43.5%), patients, patient77 with temporary dialysis (n = 7; 30.4%) and visceral malperfusion (n = 2; 8.7%) requiring stent grafting (n = 1) or laparotomy with intestinal resection (n = 1). New stroke with or without permanent sensory or motor deficit was diagnosed in 8 (34.8%) patients, patient . Temporary neurological deficits were seen in 9 (39.1%) individuals. Hospital and 1-year mortality rates were 13.0 and 30.4%, respectively. Overall survival after 36 months of the 23 patients, patient (Group I = Extra-anatomic bypass) versus the remaining 331 AADA, acute aortic dissection type A patients, patient without distal RCCA/LCCA occlusion, RCCA occlusion (Group II = no extra-anatomic bypass) was 69.6% (n = 16) in Group I vs 72.5% (n = 240) in Group II (P = 0.90). CONCLUSION: Extra-anatomic bypass for LCCA or distal RCCA/LCCA occlusion, RCCA occlusion allows for early selective cerebral perfusion during AADA, acute aortic dissection type A repair, and may reduce the risk of patients, patient6 in patients, patient with preoperative patients, patient779 .
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1824_biomrc
|
Title: Sequential targeted therapy for relapsed @entity2799 with all-trans @entity1968 and anti- XXXX monoclonal antibody M195.
Acute promyelocytic leukemia, APL ( Acute promyelocytic leukemia, APL ) provides a model to examine the sequential use of selective oncogene product-targeted and lineage-targeted agents. patients968 (RA) has been shown to produce brief remissions by a novel differentiating mechanism in most patients with Acute promyelocytic leukemia, APL . M195, a mouse monoclonal antibody (moAb) reactive with the cell-surface antigen patients116 , can target myeloid leukemia cells in patients and reduce large leukemic burdens when labeled with 131I. We studied whether 131I-M195 could safely reduce minimal residual disease and prolong remission and survival durations in patients with relapsed Acute promyelocytic leukemia, APL after they had attained remission with all-trans RA. Seven patients with relapsed Acute promyelocytic leukemia, APL in second remission were treated with either 70 (n = 2) or 50 (n = 5) mCi/m2 of 131I-M195. As a measure of minimal residual disease , we serially monitored PML/RAR-alpha mRNA by a reverse transcription polymerase chain reaction (RT-PCR) assay. There was no immediate patients37 . Late patients37 was limited to myelosuppression, but no episodes of patients398 were seen. Six patients had detectable PML/RAR-alpha mRNA after all-trans RA therapy; two had single negative RT-PCR determinations following 131I-M195. Median disease-free survival of the seven patients was 8 months (range 3-14.5). Four patients with median follow-up of 24 months remain alive, and median overall survival exceeds 21+ months (range 5.5-33+). This regimen based on targeted therapy compares favorably to other approaches for the treatment of relapsed Acute promyelocytic leukemia, APL , including that used in the immediately preceding trial in which patients were induced into remission and maintained with all-trans RA, as well as other chemotherapy-based regimens. These data support further study of moAb-based therapy for minimal residual disease in acute leukemia .
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1826_biomrc
|
Title: Application of statistical parametric mapping to SPET in the assessment of intractable childhood XXXX .
children, patients, patient2945 ( children, patients, patient2945 ) quantification and analysis has been successfully applied to functional imaging studies of epilepsy syndrome, epilepsy, partial epilepsy syndromes in adults. The present study evaluated whether localisation of the epileptogenic zone (determined by children, patients, patient2945 ) improves upon visually examined single-photon emission tomography (SPET) imaging in presurgical assessment of children, patients, patient with children, patients, patient315 ( children, patients, patient315 ) and FLE, frontal lobe epilepsy ( FLE, frontal lobe epilepsy ). The children, patients, patient sample consisted of 24 children, patients, patient (15 males) aged 2.1-17.8 years (9.8+/-4.3 years; mean+/-SD) with intractable children, patients, patient315 or FLE, frontal lobe epilepsy . SPET imaging was acquired routinely in presurgical evaluation. All children, patients, patient images were transformed into the standard stereotactic space of the adult children, patients, patient2945 SPET template prior to children, patients, patient2945 statistical analysis. Individual children, patients, patient images were contrasted with an adult control group of 22 healthy adult females. Resultant statistical parametric maps were rendered over the children, patients, patient2945 canonical magnetic resonance imaging (MRI). Two corresponding sets of ictal and interictal children, patients, patient2945 and SPET images were then generated for each children, patients, patient . Experienced clinicians independently reviewed the image sets, blinded to clinical details. Concordance of the reports between children, patients, patient2945 and SPET images, syndrome classification and MRI abnormality was studied. A fair level of inter-rater reliability (kappa=0.73) was evident for children, patients, patient2945 localisation. children, patients, patient2945 was concordant with SPET in 71% of all children, patients, patient , the majority of the discordance being from the FLE, frontal lobe epilepsy group. children, patients, patient2945 and SPET localisation were concordant with epilepsy syndrome, epilepsy, partial epilepsy syndromes in 80% of the children, patients, patient315 cases. Concordant localisation to syndrome was worse for both children, patients, patient2945 (33%) and SPET (44%) in the FLE, frontal lobe epilepsy group. Data from a small sample of children, patients, patient with varied focal structural pathologies suggested that children, patients, patient2945 performed poorly relative to SPET in these cases. Concordance of children, patients, patient2945 and SPET with syndrome was lower in children, patients, patient younger than 6 years than in those aged 6 years and above. children, patients, patient2945 is effective in localising the potential epileptogenic zone but does not provide additional benefit beyond SPET in presurgical assessment of children, patients, patient with intractable epilepsy syndrome, epilepsy, partial epilepsy syndromes . The impact of different pathologies on the efficacy of children, patients, patient2945 warrants further study.
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3874_biomrc
|
Title: Peripheral and central oculomotor organization in the @entity2083 , XXXX .
Peripheral and central oculomotor organization was studied in the goldfish . The sizes of the extraocular muscles were quantified by counting the fibers contained in a given muscle and by area measurements of the cross-sectional surfaces. All the muscles were of approximately similar size. Kinematics were determined by electrical stimulation of a given muscle. The macroscopic appearance and kinematics of the muscles had the characteristics of other lateral-eyed animals (e.g., rabbit ). Locations of extraocular motor neurons were found by retrograde transport of horseradish peroxidase (HRP) following injections into individual extraocular muscles. The eye muscles were innervated by four ipsilateral (lateral rectus, medial rectus, inferior oblique, inferior rectus) and two contralateral (superior rectus, superior oblique) motor neuron pools. The oculomotor nucleus was found in the midbrain, at the level of the caudal zone of the inferior lobe of the hypothalamus . Inferior rectus motor neurons were located rostrally in the oculomotor nucleus, whereas medial rectus, superior rectus, and inferior oblique motor neurons were intermingled in its more caudal portions. All labelled cells were located dorsally and medially to the medial longitudinal fasciculus, MLF ( medial longitudinal fasciculus, MLF ) in close proximity to either the floor of the ventricle or the midline region. Occasionally, motor neurons were interspersed within the fiber bundles of the medial longitudinal fasciculus, MLF or the exiting fibers of the oculomotor nerve. The trochlear nucleus, containing superior oblique motor neurons, was found in the immediate lateral and caudal neighborhood of the oculomotor nucleus, where its rostral border overlapped with the caudal border of the latter. The abducens nucleus, containing lateral rectus motor neurons, was located in the posterior brainstem in the neighborhood of the vestibular nuclear complex. This nucleus was divided into a rostral and a caudal portion. The axons of ipsilaterally projecting motor neurons headed toward their respective nerve roots via the shortest possible route, as did the axons of superior rectus motor neurons, which crossed the midline without detour to enter the contralateral oculomotor nerve. In contrast, trochlear motor neuron axons arched around the dorsal aspect of the ventricle through the cerebellar commissure to reach the contralateral trochlear nerve. The morphology of individual motor neurons was visualized by intrasomatic injection of HRP. Cell somata had oblong shapes, and their large dendrites were oriented laterally and ventrally. The axons did not collateralize within the midbrain region or the oculomotor nerve as far as they could be traced.(ABSTRACT TRUNCATED AT 400 WORDS)
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1828_biomrc
|
Title: Controlled Dual Growth Factor Delivery From Microparticles Incorporated Within XXXX Bone Marrow-Derived Mesenchymal Stem Cell Aggregates for Enhanced Bone Tissue Engineering via Endochondral Ossification.
UNASSIGNED: : Bone tissue engineering via endochondral ossification has been explored by chondrogenically priming cells using soluble mediators for at least 3 weeks to produce a human184 cartilage template. Although recapitulation of endochondral ossification has been achieved, long-term in vitro culture is required for priming cells through repeated supplementation of inductive factors in the media. To address this challenge, a microparticle-based growth factor delivery system was engineered to drive endochondral ossification within human bone marrow-derived mesenchymal stem cell (hMSC) aggregates. Sequential exogenous presentation of soluble transforming growth factor-b1, TGF-b1 ( transforming growth factor-b1, TGF-b1 ) and human841 ( human841 ) at various defined time courses resulted in varying degrees of chondrogenesis and osteogenesis as demonstrated by glycosaminoglycan and calcium content. The time course that best induced endochondral ossification was used to guide the development of the microparticle-based controlled delivery system for transforming growth factor-b1, TGF-b1 and human841 . Gelatin microparticles capable of relatively rapid release of transforming growth factor-b1, TGF-b1 and mineral-coated hydroxyapatite microparticles permitting more sustained release of human841 were then incorporated within hMSC aggregates and cultured for 5 weeks following the predetermined time course for sequential presentation of bioactive signals. Compared with cell-only aggregates treated with exogenous growth factors, aggregates with incorporated transforming growth factor-b1, TGF-b1 - and human841 -loaded microparticles exhibited enhanced chondrogenesis and alkaline phosphatase activity at week 2 and a greater degree of mineralization by week 5. Staining for types I and II collagen, osteopontin, and osteocalcin revealed the presence of cartilage and bone. This microparticle-incorporated system has potential as a readily implantable therapy for healing bone defects without the need for long-term in vitro chondrogenic priming. SIGNIFICANCE: This study demonstrates the regulation of chondrogenesis and osteogenesis with regard to endochondral bone formation in high-density stem cell systems through the controlled presentation of inductive factors from incorporated microparticles. This work lays the foundation for a rapidly implantable tissue engineering system that promotes bone repair via endochondral ossification, a pathway that can delay the need for a functional vascular network and has an intrinsic ability to promote angiogenesis. The modular nature of this system lends well to using different cell types and/or growth factors to induce endochondral bone formation, as well as the production of other tissue types.
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3879_biomrc
|
Title: Muscle size, strength, and bone geometry in the upper limbs of young and old XXXX .
BACKGROUND: Bone loss in old Men, men is associated with a decrease in muscle mass and strength. However, the influence of muscle size and strength on age-related changes in bone geometry has not been comprehensively described. Methods. Men, men in their third (group I, 23 +/- 3 y, n = 20), eighth (group II, 77 +/- 1 y, n = 10), and ninth (group III, 86 +/- 4 y, n = 13) decades of age were studied. The cross-sectional area (CSA) of the elbow flexors, elbow extensors, and forearm muscles, the total area (TA), cortical area (CA), and medullary area (MA) of the midhumerus, and distal third of the radius and ulna (n = 7 group II; n = 6 group III) were measured with magnetic resonance imaging. The maximal isometric strength (MVC) of the Men, men4228 was also determined. RESULTS: The CSA and MVC of the arm muscles ( Men, men4228 ) were less in group II (-17% and -22%) and III (-32% and -39%), respectively, compared to group I. However, forearm CSA was less (-21%) in group III only. The TA and MA of all bones were greater in the older groups. The CA of the humerus (-14%) and ulna (-10%), but not the radius, was less in group III compared to group I, whereas CA was unchanged in group II. Stepwise multiple linear regression determined that arm muscle CSA (r = 0.52, p <.01) and forearm muscle CSA (r = 0.41, p <.05) provided the best prediction of CA in the humerus and forearm, respectively. CONCLUSIONS: Muscle size and strength are important determinants of CA in the humerus and forearm. The lower CA in the ninth decade may be explained, in part, by reduced bone strains due to a smaller muscle mass.
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1836_biomrc
|
Title: XXXX and pregnancy.
PURPOSE: To report the course of women, Patients596 activity during pregnancy and the postpartum period in women, Patients with women, Patients596 . DESIGN: Observational case series. METHODS: The medical records of women, Patients with women, Patients596 and pregnancy during follow-up at a large eye hospital were retrospectively reviewed. women, Patients with pregnancy were included in the study if follow-up was adequate to document the presence or absence of flare-ups in women, Patients596 activity during the pregnancy and/or postpartum period. RESULTS: Seventy-six pregnancies among 50 women, Patients were included in the study. Thirty-three pregnancies were in women, Patients with Vogt-Koyanagi-Harada disease , 19 were in women, Patients with Behcet disease , and 24 were in women, Patients with idiopathic women, Patients596 . A flare-up in women, Patients596 activity occurred within the first 4 months of pregnancy in 49 of 76 cases (64%) and later in pregnancy in 17 cases (22%); no flare-up occurred during pregnancy in 21 cases (28%). An early pregnancy flare-up was typical of Vogt-Koyanagi-Harada disease and idiopathic women, Patients596 . A flare-up within 6 months of delivery occurred in 38 of 59 cases (64%) that had adequate examination data available from the postpartum period. The postpartum flare-up was especially typical of Behcet disease . CONCLUSIONS: Many women, Patients with women, Patients596 will experience a flare-up in disease activity within the first 4 months of pregnancy. Later pregnancy appears to be a time of relative disease inactivity. Many will experience a rebound in activity within 6 months of delivery.
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3887_biomrc
|
Title: Impaired interaction between efferent and afferent XXXX in SHR involves increased activation of alpha2-adrenoceptors.
Activation of efferent renal sympathetic nerve activity (ERSNA) increases afferent responsiveness of the renal sensory nerves, renal nerve activity (ARNA), leading to decreases in ERSNA by activation of the renorenal reflexes in the overall goal of maintaining low ERSNA. The renorenal reflex responses to various stimuli are impaired in spontaneously hypertensive Wistar, rats (SHR). Because renal tissue density of a(2)-adrenoceptors (ARs) is increased in SHR, we examined whether the ERSNA-induced increases in ARNA are impaired in SHR and, if so, the role of a(2)-ARs. The ARNA responses to increases in ERSNA were impaired in SHR, 2390 460% seconds, versus in Wistar, rats -Kyoto Wistar, rats , 6620 1690% seconds. Renal pelvic release of substance P was not altered by 6250 pmol/L norepinephrine (NE) in SHR but was increased by 250 pmol/L NE in Wistar, rats -Kyoto Wistar, rats , from 5.7 0.7 to 12.5 1.3 pg/min. Renal pelvic administration of the a(2)-AR antagonist rauwolscine enhanced the ERSNA-induced increases in ARNA, 4170 900% seconds, in SHR but not in Wistar, rats -Kyoto Wistar, rats . In the presence of rauwolscine , 250 pmol/L NE increased substance P release, from 5.2 0.3 to 11.2 0.8 pg/min, in pelvises from SHR. Because angiotensin II suppresses the activation of renal mechanosensory nerves in SHR, we examined whether losartan, Losartan improved the ERSNA-induced ARNA responses. losartan, Losartan had no effect on the ARNA responses or the NE-induced increases in substance P in SHR. However, losartan, Losartan + rauwolscine resulted in further enhancement of the responsiveness of the renal sensory nerves, renal nerve activity to increases in ERSNA and NE in SHR but not in WKY. We conclude that increased activation of renal a(2)-ARs and angiotensin II type 1 receptors contributes to the impaired interaction between ERSNA and ARNA in SHR.
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3888_biomrc
|
Title: Renal transplantation at the University of Pittsburgh: the impact of XXXX .
1. In an unselected adult renal transplant population, patients, patient140 as the primary immunosuppressive agent yielded one- and 2-year actuarial patients, patient survival rates of 95% and 93% and one- and 2-year actuarial graft survival rates of 89% and 83%, respectively. Forty-nine percent of successfully transplanted patients, patient were weaned off steroids . 2. In pediatric renal transplant patients, patient , patients, patient140 has been associated with 100% one- and 3-year actuarial patients, patient survival rates and 98% and 85% one- and 3-year actuarial graft survival rates, respectively. Sixty-two percent of successfully transplanted patients, patient were taken off prednisone , with dramatic improvements in height. 3. patients, patient140 has been used successfully in rescuing 70-74% of adult or pediatric renal transplant patients, patient with an acute rejection that failed conventional therapy. 4. Kidney/bone marrow transplantation under patients, patient140 therapy has been successfully performed without graft-versus-host disease and with routine augmentation of chimerism. 5. The side effects of patients, patient140 included nephrotoxicity, neurotoxicity , and diabetogenicity; they were comparable to those seen with CsA. 6. patients, patient140 is an important new addition to the immunosuppressive armamentarium in renal transplant patients, patient .
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1840_biomrc
|
Title: Development and Implementation of Tele-Savvy for XXXX Caregivers: A Department of Veterans Affairs Clinical Demonstration Project.
PURPOSE OF THE STUDY: To test fidelity and preliminary efficacy of Tele-Savvy, an internet-based version of the in- Participants, person , evidence-based psychoeducation Savvy Caregiver Program (SCP) for dementia caregivers. Tele-Savvy used synchronous (tele-conferences) and asynchronous components (video modules) to provide program access to caregivers in their homes. DESIGN AND METHODS: SCP experts were surveyed to evaluate Tele-Savvy's fidelity to SCP. A convenience sample of 30 dementia caregivers from the Atlanta VA Medical Center enrolled in the Tele-Savvy clinical demonstration program. Twenty-two caregivers completed both pre- and postprogram evaluations, which included measures of caregiver stress and competence and Participants, person46 ( Participants, person46 ). RESULTS: Expert review confirmed Tele-Savvy's fidelity with and, in certain domains, improvement on the original. Participants, person demonstrated moderately high initial levels of burden, Participants, person48 , and depressive symptoms all of which decreased significantly postprogram in an intention to treat analysis. Similar reductions were seen in care recipients' Participants, person46 and caregivers' reactions to them. Marginally significant increases in caregiver competence were observed. Caregiver and expert panel evaluations of program quality were enthusiastic. IMPLICATIONS: An effective online caregiver psychoeducation program could provide greatly expanded access for caregivers who cannot attend in Participants, person for reasons of distance, transportation limitations, and caregiving responsibilities. Further testing in a controlled trial is needed to establish program efficacy.
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1841_biomrc
|
Title: [Multiple derotation plus costotransversectomy for severe and XXXX ].
OBJECTIVE: To explore the outcomes of multiple derotation plus costotransversectomy for patients with severe and rigid scoliosis . METHODS: Clinical analyses were conducted for the clinical data of operative duration, patients90 volume and SRS-22 scale. Radiographic data included Cobb angle of coronal curves, apical vertebral translation, coronal balance and sagittal balance. All measurements were taken pre-operation, post-operation and during the final follow-up period. RESULTS: The mean follow-up period was 4.1 0.7 (3-5.5) years, mean operative duration 33 8.4 min and mean patients90 volume 2303.5 9.0 ml. Preoperative major curves ranged from 65 to 110 Cobb angle. Coronal plane correction of major curve from 10 to 41 Cobb angle (mean 30.8 9.8 ). And there was a mean loss of correction of 3.6% during the final follow-up. The magnitudes of patients513 and patients515 were 31.1 12.4 , 45.5 10.5 pre-operation, 25.6 5.5 , 33.43 5.45 post-operation and 28.6 6.1 , 35.26 4.2 during the final follow-up. The apical vertebral translation of major curve was corrected by 73.2%. The coronal imbalance, sagittal imbalance and apical vertebral translation indifferently was 3.2 1.1, 2.3 1.1, 6.35 1.65 cm pre-operation, 0.9 1.0, 0.4 0.5, 2.4 1.2 cm post-operation and 1.2 1.1, 0.6 0.5, 2.6 1.4 cm during the final follow-up. Incomplete patients514 occurred in one case and superficial dermatoedge necrosis in another recovered within 2 weeks. Neither malposition of pedicle screw nor complication of instrumentation was found. Excellent outcomes were obtained according to SRS-22 score. CONCLUSION: For patients with severe and rigid scoliosis , the technique of multi-rod-derotation and rib resection may achieve a good correction of patients635 without serious complications and avoid a resection of vertebral column.
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1846_biomrc
|
Title: Sensitive quantification of @entity526 O157:H7, @entity11621 , and XXXX by combining stopped polymerase chain reaction with chemiluminescence flow-through DNA microarray analysis.
Rapid analysis of pathogenic bacteria is essential for food and water control to preserve the public health. Therefore, we report on a chemiluminescence (CL) flow-through DNA microarray assay for the rapid and sensitive quantification of the pathogenic bacteria Escherichia coli, E. coli O157:H7, Salmonella enterica, S. enterica , and Campylobacter jejuni, C. jejuni in water. Using the stopped polymerase chain reaction (PCR) strategy, the amount of amplified target DNA was strongly dependent on the applied cell concentration. The amplification was stopped at the logarithmic phase of the PCR to quantify the DNA products on the DNA microarray chip. The generation of single-stranded DNA sequences is essential for DNA hybridization assays on microarrays. Therefore, the DNA strands of the PCR products were separated by streptavidin-conjugated magnetic nanoparticles. This was achieved by introducing a reverse primer labeled with biotin together with a digoxigenin labeled forward primer for CL microarray imaging. A conjugate of an antidigoxigenin antibody and horseradish peroxidase recognized the digoxigenin -labeled antistrands bound to the probes on the microarray surface and catalyzed the reaction of luminol and hydrogen peroxide . The generated light emission was recorded by a sensitive charge-coupled device, CCD ( charge-coupled device, CCD ) camera. The quantification was conducted by a flow-through CL microarray readout system. The DNA microarrays were based on an NHS-activated poly(ethylene glycol) -modified glass substrate. The DNA probes which have the same DNA sequence as the reverse primer were immobilized on this surface. The full assay was characterized by spiking experiments with heat-inactivated bacteria in water. The total assay time was 3.5 h, and the detection limits determined on CL microarrays were for Escherichia coli, E. coli O157:H7, Salmonella enterica, S. enterica , and Campylobacter jejuni, C. jejuni 136, 500, and 1 cell/mL, respectively. The results of the DNA microarray assay were comparable to the SYBR green-based assays analyzed with a real-time PCR device. The advantage of the new microarray analysis method is seen in the ability of a high multiplex degree on DNA microarrays, the high specificity of DNA hybridization on DNA microarrays, and the possibility to get quantitative results on an automated CL flow-through microarray analysis system.
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1848_biomrc
|
Title: The effects of anterior cruciate ligament lesion on the articular cartilage of growing XXXX .
Treatment of anterior cruciate ligament (ACL) injury in skeletally immature children, patients is controversial. The growth plate could be damaged if treated with the reconstruction techniques used to treat instability in adults. For this reason, many authors postpone surgical treatment until skeletal maturity, but the acceptable length of time that treatment can be postponed without causing irreversible damage to the articular cartilage in children, patients with children, patients30 is unknown. Until now, no studies have described the pathological findings and the evolution of the lesions of the articular cartilage during the growing period. For this reason, an experimental study on 16 6-month-old, skeletally immature children, patients237 was performed. A complete ACL lesion was achieved by removing the ligament. Two animals per group were sacrificed at intervals of 1, 3, 6, and 9 months postoperatively, and macroscopic and microscopic evaluations were performed. The presence of children, patients30 and articular cartilage lesions with progressive aspects were histologically underlined. The hystological observations showed that the complete ACL lesion causes irreversible articular cartilage alterations in growing children, patients237 3 months after injury. These experimental data suggest that ACL reconstruction in growing children, patients with children, patients30 and instability should be indicated without waiting until skeletal maturity.
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3897_biomrc
|
Title: Physical conditions and challenging behaviour in @entity1 with XXXX : a systematic review.
BACKGROUND: Challenging behaviour is a major problem among people with intellectual disabilities . Physical factors may be an important cause. The aim of the present systematic review was to determine the physical conditions associated with challenging behaviour. METHODS: A literature search was conducted in PubMed and the Cochrane systematic review database for empirical studies published between 1990 and 2008. The quality of all the studies that met the inclusion criteria was assessed using the SIGN-50 methodology checklists. RESULTS: The search identified 45 studies, which looked at general medical conditions, motor impairment, mobility impairment , epilepsy, sensory impairment , gastrointestinal disease , sleep disorders, chronic sleep problems , dementia and others. There were four high-quality observational studies, seven well-conducted observational studies, 21 observational studies of low methodological quality and 13 non-analytical studies. There were significant and independent associations between challenging behaviours and bowel incontinence, urinary incontinence , people58 related to cerebral palsy and sleep disorders, chronic sleep problems , and between self-injurious behaviour and visual impairment . No association was found with hearing impairment , bowel incontinence, urinary incontinence , motor impairment, mobility impairment or epilepsy . Many other physical conditions were not addressed at all. CONCLUSION: Medical conditions can play a role in challenging behaviour, and this should be evaluated in the clinical setting. So far, the level of evidence is generally low, and longitudinal studies are completely lacking. We recommend a systematic approach to research examining the role of physical conditions in challenging behaviour, the ultimate aim being to establish a basis for the development of clinical guidelines.
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1850_biomrc
|
Title: [The effect of therapeutic intervention with XXXX on outcome and prognosis of @entity370 ].
OBJECTIVE: To evaluate the effects of corticosteroids on the prognosis of sarcoidosis . METHOD: There were analysis and comparison on the prognosis of natural course and corticosteroids therapy of 133 patients, patient with sarcoidosis diagnosed by biopsy pathologic histology follow-up over 4 years. RESULTS: Six of the 7 patients, patient with ocular sarcoidosis were cured by oral prednisone (PRED), and 1 patients, patient receiving intraocular dexamethasone lost his sight. In patients, patient with extra- patients, patient0070 who were not treated, 33 of the 38 cases underwent spontaneous remission, but another 5 cases progressed. Twenty-two of the 26 patients, patient with stage I pulmonary disease underwent spontaneous remission, 3 progressed, with only one case cured by PRED therapy. In the 55 patients, patient with stage II patients, patient0070 who received PRED therapy, the chest roentgenogram and lung function were back to normal in 45 cases, but 10 cases failed. One patients, patient with stage II pulmonary disease without treatment progressed to stage IV. Three patients, patient with stage III patients, patient0070 were cured by PRED therapy, but III patients, patient with stage IV sarcoidosis failed to respond to PRED therapy. CONCLUSIONS: Systematic therapy with oral corticosteroids for ocular and stage II approximately III patients, patient0070 is a curative intervention. stage II pulmonary disease88 can relieve symptoms, reduce inflammation , and improve the prognosis of ocular and patients, patient0070 .
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1852_biomrc
|
Title: A one-way text messaging intervention for XXXX .
INTRODUCTION: Worldwide, there has been a startling increase in the number of participants, human, Participants, people who are obese or overweight. Obesity increases the risk of cardiovascular disease and overall mortality. Mobile phone messaging is an important means of participants, human, Participants, people communication globally. Because the mobile phone can be used anywhere at any time, mobile phone messaging has the potential to manage obesity . We investigated the effectiveness of a one-way text messaging intervention for obesity . METHODS: participants, human, Participants, people ' body mass index and waist circumference were measured at the beginning of the programme and again after 12 weeks. The text message group received text messages about exercise, dietary intake, and general information about obesity three times a week, while the control group did not receive any text messages from the study. RESULTS: Of the 80 participants, human, Participants, people , 25 subjects in the text message group and 29 participants, human, Participants, people in the control group completed the study. After adjusting for baseline body mass index, the body mass index was significantly lower in the text message group than in the control group (27.9 vs 28.3; p = 0.02). After adjusting for the baseline waist circumference, the difference of waist circumference between the text message group and control group was not significant (93.4 vs 94.6; p = 0.13). DISCUSSION: The one-way text messaging intervention was a simple and effective way to manage obesity . The one-way text messaging intervention may be a useful method for lifestyle modification in obese subjects.
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3906_biomrc
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Title: XXXX with early @entity5 progression: a clinicopathologic and molecular study.
SSA, Sessile serrated adenoma ( SSA, Sessile serrated adenoma ), also referred to as sessile serrated polyp, HPs, hyperplastic polyps , has been proposed as a precursor lesion to microsatellite unstable submucosal invasive carcinoma, HGD/intramucosal carcinoma, submucosal carcinoma, carcinoma, invasive carcinoma . However, the mechanism of stepwise progression from SSA, Sessile serrated adenoma to early submucosal invasive carcinoma, HGD/intramucosal carcinoma, submucosal carcinoma, carcinoma, invasive carcinoma has been unclear. The purpose of this study was to elucidate the histologic characteristics and possible role of p53 , b-catenin , BRAF , KRAS , and PIK3CA in the development and progression of SSA, Sessile serrated adenoma . We analyzed 12 cases of SSA, Sessile serrated adenoma with neoplastic progression (SSAN), including 7 cases of intraepithelial submucosal invasive carcinoma, HGD/intramucosal carcinoma, submucosal carcinoma, carcinoma, invasive carcinoma3 ( submucosal invasive carcinoma, HGD/intramucosal carcinoma, submucosal carcinoma, carcinoma, invasive carcinoma3 ) and 5 cases of submucosal invasive carcinoma, HGD/intramucosal carcinoma, submucosal carcinoma, carcinoma, invasive carcinoma , and compared them with 53 SSAs and 66 sessile serrated polyp, HPs, hyperplastic polyps ( sessile serrated polyp, HPs, hyperplastic polyps ) by immunohistochemistry and gene mutation analysis. Histologically, 75% (9 of 12) of SSANs showed tubular or tubulovillous growth patterns rather than serrated ones in the submucosal invasive carcinoma, HGD/intramucosal carcinoma, submucosal carcinoma, carcinoma, invasive carcinoma component. All 5 SSANs with submucosal invasive carcinoma, HGD/intramucosal carcinoma, submucosal carcinoma, carcinoma, invasive carcinoma lost their serrated structure and developed increased extracellular mucin in their submucosal invasive carcinoma, HGD/intramucosal carcinoma, submucosal carcinoma, carcinoma, invasive carcinoma component, a consistent feature of mucinous adenocarcinoma . Nuclear accumulations of b-catenin and p53 were observed in 50% (6 of 12) and 41.7% (5 of 12) of SSANs, respectively, and were exclusively present in submucosal invasive carcinoma, HGD/intramucosal carcinoma, submucosal carcinoma, carcinoma, invasive carcinoma3 / submucosal invasive carcinoma, HGD/intramucosal carcinoma, submucosal carcinoma, carcinoma, invasive carcinoma areas. By contrast, neither nuclear b-catenin nor p53 expressions were seen in sessile serrated polyp, HPs, hyperplastic polyps or SSAs (P<0.0001). BRAF mutations ( V600E ) were observed in 45.8% (11 of 24) of sessile serrated polyp, HPs, hyperplastic polyps , 60.9% (14 of 23) of SSAs, and 63.6% (7 of 11) of SSANs, and were equally found in both SSA, Sessile serrated adenoma and submucosal invasive carcinoma, HGD/intramucosal carcinoma, submucosal carcinoma, carcinoma, invasive carcinoma / submucosal invasive carcinoma, HGD/intramucosal carcinoma, submucosal carcinoma, carcinoma, invasive carcinoma3 areas of the individual SSANs. KRAS exon 1 mutations were uncommon in all 3 groups (4.2%, 4.4%, and 0%, respectively). No mutations of PIK3CA exon 9 or exon 20 were found in any cases that were examined. These findings suggest that BRAF mutations may be associated with the pathogenesis of SSA, Sessile serrated adenoma , but progression to submucosal invasive carcinoma, HGD/intramucosal carcinoma, submucosal carcinoma, carcinoma, invasive carcinoma3 or early submucosal invasive carcinoma, HGD/intramucosal carcinoma, submucosal carcinoma, carcinoma, invasive carcinoma may be associated with other factors, such as alterations of p53 and b-catenin . In addition, our histologic observations suggest a possible close association between SSAN and mucinous adenocarcinoma .
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1863_biomrc
|
Title: Adrenal autoantibodies and XXXX in @entity1723 .
Stored sera from 466 human, patients, Patients with human, patients, Patients723 and from 144 controls were examined for organ-specific antibodies to human, patients, Patients adrenal cortex. Adrenal antibodies were found in seven of the human, patients, Patients with human, patients, Patients723 (1.5%) and in one control (0.7%). None of 91 black human, patients, Patients with human, patients, Patients723 had adrenal antibodies. All of the seven human, patients, Patients with adrenal antibodies had other organ-specific antibodies. Three had clinical human, patients, Patients375 and one was thyrotoxic . All of these seven human, patients, Patients had a HLA-B8-bearing haplotype, suggesting that the B8-bearing haplotype confers an extremely high "relative risk" for adrenal autoimmunity in human, patients, Patients723 . Organ-specific autoimmune disease and/or organ-specific antibodies were found in 30% of the first-degree relatives of these eight probands with the adrenal antibodies (seven with human, patients, Patients723 and one control). We conclude that screening human, patients, Patients with human, patients, Patients723 for adrenal antibodies of low yield (1.9% among white human, patients, Patients ). Further, adrenal antibodies may be present for at least two years without the development of Addison disease . Antibodies reactive only to the zona glomerulosa of the adrenal cortex may be benign. human, patients, Patients with human, patients, Patients723 and thyroid microsomal antibodies are more likely to have adrenal antibodies (6.5%), as are human, patients, Patients with human, patients, Patients723 and a B8-bearing haplotype and those with human, patients, Patients723 and family histories of organ-specific autoimmunity.
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1864_biomrc
|
Title: MicroRNA-9 promotes tumorigenesis and mediates sensitivity to @entity900 in primary XXXX cells.
UNASSIGNED: MicroRNAs play critical roles in regulating tumor occurrence and drug ovarian cancers, sensitivity in ovarian cancers, ovarian tumor, ovarian cancer . This study aimed to investigate the key members of MicroRNAs (miRNAs) involved in modulating tumor initiation and drug resistance in primary ovarian cancers, sensitivity in ovarian cancers, ovarian tumor, ovarian cancer cells. An in vitro assay based on tumor clonal formation was established to evaluate tumorigenicity and cisplatin, Cisplatin sensitivity. By performing real-time polymerase chain reaction, we examined the expression of nine microRNAs associated with the pathology of ovarian cancers, sensitivity in ovarian cancers, ovarian tumor, ovarian cancer in primary ovarian cancers, sensitivity in ovarian cancers, ovarian tumor, ovarian cancer cells, which were surgically resected from 46 patients with distinct sensitivity to platinum -based chemotherapy. MiR-9, miR-145 , and miR-429 were expressed significantly higher in drug-sensitive patients (n = 26) than in drug-resistant ones (n = 20), while higher patients7309 expression was found in resistant patients (p < 0.05). In addition, tumor cells from drug sensitive patients were more tumorigenic than those of drug resistance (p = 0.0013). cisplatin, Cisplatin treatment led to a sharp decrease of clonal formation of drug-sensitive cells but showed slight effects on drug resistant cells. Specific anti-miRs were then employed to downregulate the expression of microRNAs in primary tumor cells. Inhibition of miR-9 resulted in decreased clonal formation and sensitivity to cisplatin, Cisplatin , while the knockdown of other three microRNAs did not show any influence in tumorigenesis and drug sensitivity. In conclusion, this study showed that in primary ovarian cancers, sensitivity in ovarian cancers, ovarian tumor, ovarian cancer cells, high expression of miR-9 was associated with enhanced tumorigenesis and increased sensitivity of the tumor cells to cisplatin, Cisplatin treatment.
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3913_biomrc
|
Title: [Startup, stable operation and process failure of EBPR system under the low temperature and low dissolved XXXX condition].
A sequencing batch reactor (SBR) was started up and operated with alternating anaerobic/oxic (An/O) to perform enhanced biological phosphorus removal (EBPR) under the condition of 13-16 degrees C. The results showed that under the condition of low temperature, the EBPR system was successfully started up in a short time (<6 d). The reactor achieved a high and stable phosphorus removal performance with an influent phosphate concentration of 20 mg x L(-1) and the dissolved oxygen (DO) concentration of 2 mg x L(-1). The effluent phosphate concentration was lower than 0.5 mg x L(-1). It was found that decreasing DO had an influence on the steady operation of EBPR system. As DO concentration of aerobic phase decreased from 2 mg x L(-1) to 1 mg x L(-1), the system could still perform EBPR and the phosphorus removal efficiency was greater than 97.4%. However, the amount of phosphate released during anaerobic phase was observed to decrease slightly compared with that of 2 mg x L(-1) DO condition . Moreover, the phosphorus removal performance of the system deteriorated immediately and the effluent phosphate concentration couldn't meet the national integrated wastewater discharge standard when DO concentration was further lowered to 0.5 mg x L(-1). The experiments of increasing DO to recover phosphorus removal performance of the EBPR suggested the process failure resulted from low DO was not reversible in the short-term. It was also found that the batch tests of anoxic phosphorus uptake using nitrite and nitrate as electron acceptors had an impact on the stable operation of EBPR system, whereas the resulting negative influence could be recovered within 6 cycles. In addition, the mixed liquid suspended solids (MLSS) of the EBPR system remained stable and the sludge volume index (SVI) decreased to a certain extend in a long run, implying long-term low temperature and low DO condition favored the sludge sedimentation.
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3915_biomrc
|
Title: Expression of natural killer cell markers in XXXX .
One hundred forty-nine cases of "non-Hodgkins lymphoma" were studied with a panel of monoclonal antibodies, including antibodies to natural killer (NK) cells--anti-NKH1, anti- Leu 7 , and anti-Leu 11b. There were 95 B-cell, 51 T-cell, and three null cell paranasal lymphomas, lymphomas . T-cell lymphomas, Seventeen T-cell lymphomas (33 per cent) expressed NKH1, Leu 7 , and/or Leu 11b. None of the B- or null cell paranasal lymphomas, lymphomas expressed the NK markers. In comparison with the NK-negative T-cell lymphomas, Seventeen T-cell lymphomas , the NK-positive cases showed a predilection for the nasal and paranasal region. There was a more significant loss of the T-cell markers T3 (peripheral T cell) and T4 (T-helper cell) in NK-positive paranasal lymphomas, lymphomas . The difference was due to a high proportion of nasal/ paranasal lymphomas, lymphomas , which were associated with a frequent loss of T-cell markers, among the NK-positive cases. However, a similar degree of loss of T-cell markers was observed among NK-positive and NK-negative nasal/ paranasal lymphomas, lymphomas . We conclude that expression of NK markers occurs exclusively in a proportion of T-cell lymphomas, Seventeen T-cell lymphomas , but not B-cell or null cell paranasal lymphomas, lymphomas . The reason this occurs predominantly in nasal and paranasal lymphomas, lymphomas is unknown.
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1871_biomrc
|
Title: XXXX and @entity876 protein expression in sporadic @entity14 .
AIMS: To ascertain if a relationship between retinoblastoma ( pRb ) and p53 proteins exists in sporadic patients4 . METHODS: Fifty consecutive colectomy specimens for patients4 in patients over the age of 50 and with no family history of cancers, cancer, low-stage cancers, advanced-stage carcinomas, tumours in the bowel were examined for immunoexpression of pRb and p53 proteins. These findings were then related to clinicopathological findings. Commercially available monoclonal antibodies to pRb and p53 were used on formalin -fixed, paraffin -embedded tissue. RESULTS: The most intense pRb immunoexpression was detected in well-differentiated, cancers, cancer, low-stage cancers, advanced-stage carcinomas, tumours . On the other hand, p53 expression was most intense in poorly differentiated, cancers, cancer, low-stage cancers, advanced-stage carcinomas, tumours . No statistically significant associations were noted with immunoexpression and age, gender or site of lesion. CONCLUSIONS: This study indicates that there is an inverse relationship between pRb and p53 protein expression in a proportion of sporadic patients4 . Twelve cancers, cancer, low-stage cancers, advanced-stage carcinomas, tumours which showed low levels of pRb showed high levels of p53 protein. Similarly, seven cancers, cancer, low-stage cancers, advanced-stage carcinomas, tumours with high pRb levels displayed low p53 expression. In terms of immunohistochemical profile, p53 -high/ pRb -low cancers, cancer, low-stage cancers, advanced-stage carcinomas, tumours tended to be poorly differentiated and have advanced stage cancers, cancer, low-stage cancers, advanced-stage carcinomas, tumours .
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3921_biomrc
|
Title: @entity479 responsive chronic @entity5422 reminiscent of XXXX : a case report.
UNASSIGNED: A 62-year-old woman presented at our hospital with a woman0 , cognitive decline, cognitive dysfunction , and fever that had persisted for 3 months. On admission, fever , woman0 , and mild cognitive decline, cognitive dysfunction were all clearly evident, suggesting chronic malignant tumors422 . Laboratory examination showed mild steroid5 as well as an increase in her erythrocyte sedimentation rate and serum woman851 levels. MRI showed multiple small hyperintense lesions on T2 weighted image and diffusion weighted image (DWI) in the cerebral cortex and white matter. Contrast-enhanced T1 weighted image showed the abnormal pial enhancement along the cerebral sulci. Systemic evaluations for infectious organisms, autoantibodies, and malignant tumors were all negative. Her fever and woman6 continued. As a result of worsening MRI findings, a brain biopsy was carried out. Neuropathological analysis revealed neutrophilic infiltration in the subarachnoid space and multinucleated giant cells. However, there was no woman333 on the histological sections. This pathological finding was reminiscent of rheumatoid meningitis despite articular findings of rheumatoid arthritis , as well as rheumatoid factor (RF) and anti-CCP antibody tests being negative. After oral steroid therapy, her fever and inflammatory reactions by laboratory test diminished and her cognitive function improved remarkably.
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