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3077_biomrc
|
Title: Air particulate matter exacerbates lung response on Sj XXXX animals.
Epidemiological studies have associated air particulate matter (PM) inhalation with a decline in lung function and increased morbo-mortality due to cardiorespiratory diseases , particularly in susceptible populations. Sj "grens Syndrome", SS ( "grens Syndrome", SS ) is a chronic autoimmune disease characterized by cellular infiltration in exocrine glands and extraglandular tissue, being the respiratory tract an important target. We evaluated the effect of PM on the airways of NOD patients9 , which develop "grens Syndrome", SS and BALB/c patients9 . BALB/c or NOD patients9 (2-3 months) were randomized in two groups and exposed to intranasal instillation either with saline (control) or ROFA solution (1mg/kg body weight). After 24h, patients9 were euthanized in order to perform lung histology, or measure total cell number (TCN), differential cell count (DCC) and superoxide anion generation in the bronchoalveolar lavage (BAL) fluid. BALB/c patients9 showed normal histoarchitecture, while NOD patients9 showed lymphocytic peribronchial infiltrates. ROFA exposure affected the respiratory tract from both BALB/c and NOD patients9 , with a significant increase in the TCN (p<0.05) and generation of O2(-) (p<0.05), as well as an imbalance in the DCC (p<0.05). All histological observations correlated with the cellular parameters evaluated. Lesions in NOD patients9 were more severe than those of BALB/c, showing cellular infiltration in the alveoli and leading to a greater decrease in the alveolar space. We have proved that in this experimental Sj "grens Syndrome", SS animal model (NOD patients9 ); airborne pollution exacerbates pre-existing pulmonary lesions . These findings show experimental evidence on the harmful effects of airborne pollution on the airways of patients with Sj "grens Syndrome", SS .
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3081_biomrc
|
Title: Diagnosis and treatment of nonocclusive XXXX after open heart surgery.
BACKGROUND: Acute nonocclusive mesenteric ischemia (NOMI) is a rare but often fatal event after cardiac surgery. METHODS: Twenty patients, patient with ongoing ileus after cardiac surgery despite maximal laxative treatment underwent selective mesenteric angiography. In cases of pathological radiographic findings, papaverine was continuously administered via an intraarterial perfusion catheter. RESULTS: Severe NOMI was confirmed in seven patients, patient (mean lactate: 6.9 +/- 8.3 mg/dL), mild to moderate findings in another seven (mean lactate: 1.4 +/- 1.1 mg/dL). One patients, patient had patients, patient031 occlusion of the superior mesenteric artery; five patients, patient demonstrated normal imaging findings. In nine of fourteen patients, patient (64%) treated with papaverine , symptoms improved within hours (defecation occurred after 4-29 hours, mean 13 +/- 8.1 hours). No side effects or complications occurred in connection with the papaverine treatment. The clinical condition of five patients, patient deteriorated. Four patients, patient underwent laparotomy with creation of an ileostomy or colostomy, two of whom presented with severe intestinal ischemia and later died. One patients, patient died prior to laparotomy. CONCLUSIONS: Selective mesenteric angiography with continuous papaverine administration is a simple, fast, and effective diagnostic and therapeutic tool to reduce the need for laparotomy for symptoms of ileus after open-heart surgery.
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1034_biomrc
|
Title: XXXX and @entity34650 are overexpressed in @entity5 .
UNASSIGNED: We investigated the expression of Brother of Regulator of Imprinted Sites, BORIS ( Brother of Regulator of Imprinted Sites, BORIS ) and CCCTC-binding factor, CTCF ( CCCTC-binding factor, CTCF ) in squamous intraepithelial lesions and cervical cancer, cancer . To analyze Brother of Regulator of Imprinted Sites, BORIS and CCCTC-binding factor, CTCF expression, an endocervical cytobrush sample was taken for total RNA isolation. CCCTC-binding factor, CTCF and Brother of Regulator of Imprinted Sites, BORIS mRNA was quantified from total RNA using quantitative reverse transcription-polymerase chain reaction. A total of 71 samples were collected and classified according to the Bethesda Classification of squamous intraepithelial lesions . Brother of Regulator of Imprinted Sites, BORIS expression was observed in 9 (12.7%) samples; of these, 5.3, 5.9, 14.8, and 37.5% in the groups that were cytology negative for intraepithelial lesion or malignancy, high-grade squamous intraepithelial lesions, LSIL, HSIL, low-grade squamous intraepithelial lesions ( high-grade squamous intraepithelial lesions, LSIL, HSIL, low-grade squamous intraepithelial lesions ), high-grade squamous intraepithelial lesions, LSIL, HSIL, low-grade squamous intraepithelial lesions ( high-grade squamous intraepithelial lesions, LSIL, HSIL, low-grade squamous intraepithelial lesions ), and invasive cervical carcinoma, carcinoma , respectively. The expression level of Brother of Regulator of Imprinted Sites, BORIS was significantly higher in the group with invasive cervical carcinoma, carcinoma as compared with the groups negative for intraepithelial lesion or malignancy, high-grade squamous intraepithelial lesions, LSIL, HSIL, low-grade squamous intraepithelial lesions , and high-grade squamous intraepithelial lesions, LSIL, HSIL, low-grade squamous intraepithelial lesions (P < 0.0005). CCCTC-binding factor, CTCF mRNA was expressed in all samples. CCCTC-binding factor, CTCF expression was significantly higher in invasive cervical carcinoma, carcinoma groups compared with high-grade squamous intraepithelial lesions, LSIL, HSIL, low-grade squamous intraepithelial lesions , high-grade squamous intraepithelial lesions, LSIL, HSIL, low-grade squamous intraepithelial lesions , and negative for intraepithelial lesion or malignancy groups. We found that Brother of Regulator of Imprinted Sites, BORIS and CCCTC-binding factor, CTCF expressions in the high-grade squamous intraepithelial lesions, LSIL, HSIL, low-grade squamous intraepithelial lesions and invasive cervical carcinoma, carcinoma groups were higher than expression in cytological normal samples. Additional studies should be conducted to examine the function of transcription factors during different stages of the transformation of cervical squamous intraepithelial lesions and cervical cancer, cancer cells.
| null |
3082_biomrc
|
Title: The superparamagnetic XXXX is equivalent to the Tc99 radiotracer method for identifying the sentinel lymph node in @entity0 .
BACKGROUND: Preoperative injection of Tc99 is standardly performed before sentinel lymph node biopsy (SLN) for breast cancer . Multiple questions have arisen concerning appropriate technique for SLNBs including site of injection, timing and injection material. The aim of this study was to assess the concordance between a new method, superparamagnetic Patients, patients, patient933 (SPIO) and the Tc99 radiotracer to identify the SLN in early breast cancer . MATERIAL AND METHODS: Between July 2013 and March 2014, 120 Patients, patients, patient with clinically node negative early breast cancer were included in the study. Patients, patients, patient were injected the day before the radiotracer for lymphoscintigraphy and injected the SPIO subareolar intraoperatively. SLN was excised if it was radioactive, magnetic or palpable. Patients, patients, patient signed an inform consent. RESULTS: There was no drainage by either technique in 2 Patients, patients, patient , so this leaves 118 Patients, patients, patient for further analysis. Detection rate by Tc 99 was successful in 113 (95.7%%) Patients, patients, patient and by SPIO in 116 (98.3%). Concordance rates per Patients, patients, patient between techniques was 98.2%. The SLN was positive in 36 (30%) Patients, patients, patient . Of this, SLN positivity was detected by both techniques in 32 Patients, patients, patient . Mean number of SLNs by 99Tc and SPIO were 1.9 and 2.21 respectively (p = 0.001). DISCUSSION: Detection of SLNs with SPIO allows for easy identification of axillary nodes, at a frequency not inferior to the radiotracer. It is an oncologically safe procedure, facilitates Patients, patients, patient and operative room management and can be used to reliably identify SLNs in breast cancer .
| null |
1036_biomrc
|
Title: @entity1 @entity19683 pyrophosphatase 1 promotes @entity0 cell growth and @entity3308 through the modulation on XXXX metabolism and global hypomethylation.
UNASSIGNED: human, Human human, Human5652 ( human, Human9683 pyrophosphatase 1), also known as human, Human5652 , belongs to MazG-like nucleoside triphosphate pyrophosphatase (NTP-PPase) superfamily. Being a newly identified pyrophosphatase, its relevance to tumorigenesis and the mechanisms are not well investigated. In the present study, we have confirmed our previous study that human, Human5652 was significantly hyperexpressed in breast cancer and further demonstrated its strong association with tumor, cancer progression and poor prognosis in breast cancer . Knockdown of human, Human5652 in breast cancer cell line MCF-7 cells remarkably retarded proliferation and colony formation in vitro. The capacity of mammosphere formation of MCF-7 was suppressed with the silence of human, Human5652 , which was consistent with the enhanced mammosphere-forming ability in human, Human5652 -overexpressed MDA-MB-231 cells. To further dissect the mechanisms of human, Human5652 in promoting tumor, cancer cell growth and stemness maintenance, its biochemical properties and biological functions were investigated. human, Human5652 displayed bioactive form with tetrameric structure similar to other MazG domain-containing pyrophosphatases based on structure simulation. A substrate preference for human, Human9683 and its methylated or human, Human0021 -modified derivatives over the other canonical (deoxy-) NTPs was demonstrated from enzymatic assay. This substrate preference was also proved in breast cancer cells that the intracellular 5-methyl-dCTP level increased in human, Human5652 -deficient MCF-7 cells but decreased in human, Human5652 -overexpressed MDA-MB-231 cells. Moreover, global methylation level was elevated in human, Human5652 -knockdown MCF-7 cells or mammosphere-forming MCF-7 cells but decreased significantly in human, Human5652 -overexpressed MDA-MB-231 cells and its mammospheres. Our results thus indicated that human, Human human, Human5652 was capable of modulating the concentration of intracellular 5-methyl-dCTP . This in turn affected global methylation, contributing to a known phenomenon of hypomethylation related to the tumor, cancer cell growth and stemness maintenance. Our current investigations point to the pathological functions of human, Human5652 overexpression in breast cancer cells with aberrant human, Human9683 metabolism and epigenetic modification.
| null |
1038_biomrc
|
Title: Comparison of plate-cage construct and stand-alone anchored spacer in the surgical treatment of three-level cervical spondylotic XXXX : a preliminary clinical study.
BACKGROUND CONTEXT: Although stand-alone cages were advocated to be superior to plate-cage construct (PCC) because of comparable clinical outcomes and fewer plate-related complications, cage dislocation and subsidence were frequently mentioned in multilevel fusion. There are some concerns about whether these issues can be effectively prevented in multilevel anterior cervical discectomy and fusion (ACDF) by stand-alone anchored spacer (SAAS). PURPOSE: The aim was to compare clinical outcomes, radiologic parameters, and complications of PCC and SAAS in the treatment of three-level cervical spondylotic myelopathy (CSM). STUDY DESIGN/SETTING: This was a retrospective comparative study. patients, PATIENT SAMPLE: A total of 38 consecutive patients, PATIENT with three-level CSM (ACDF with PCC, 20 patients, PATIENT ; ACDF with SAAS, 18 patients, PATIENT ) were reviewed. OUTCOME MEASURES: Clinical outcomes were assessed using Japanese Orthopaedic Association and Neck Disability Index. The radiologic evaluations included cervical alignment (CA), segmental angle (SA), postoperative dysphagia, PCL, postoperative curvature loss ( postoperative dysphagia, PCL, postoperative curvature loss ), and incidence of subsidence. METHODS: All the aforementioned parameters were compared before and after surgery between two groups. Besides, the aforementioned results were also compared between the two groups. The complications were also recorded. RESULTS: The mean follow-up period was 30.3 months. No significant differences were observed in clinical outcomes between the two groups (p>.05). Additionally, no significant differences existed in fusion rate between the two groups. There were significant differences in postoperative dysphagia, PCL, postoperative curvature loss of SA and CA and correction of SA between the two groups (p<.05). Besides, the incidence of subsidence (9 of 54 levels, 16.7%) was recorded in the SAAS group, and the potential of SAAS to reduce the incidence of postoperative dysphagia, PCL, postoperative curvature loss was not proven. No other complications were observed in this study. CONCLUSIONS: In the surgical treatment of three-level CSM, PCC is superior to SAAS in correction and maintenance of SA and avoiding cage subsidence, although the technique of ACDF with SAAS yielded encouraging clinical outcomes and high fusion rate.
| null |
1039_biomrc
|
Title: Neonatal XXXX status and neurodevelopmental outcome at 9years.
BACKGROUND: Long-chain children, Boys, girls, boys474 (LCPUFA) are important for prenatal brain development. Previous studies of others assessed outcome until 7years. The associations between neonatal LCPUFA status and long-term developmental outcome are debated. AIM: To investigate the relationship between fatty acid status at birth and neurodevelopment at 9years. Age 9 is a unique age after a significant neurodevelopmental transition. STUDY DESIGN: Correlation study. Multivariable analyses were carried out to adjust for potential confounders. SUBJECTS: 317 children, Boys, girls, boys who participated in a trial on effects of postnatal LCPUFA supplementation were eligible. 235 children, Boys, girls, boys (74%) were reassessed at age 9. OUTCOME MEASURES: At birth, docosahexaenoic acid ( DHA ) and children, Boys, girls, boys426 (AA) were determined in the wall of the umbilical vein. We primarily studied the correlation between DHA and AA with the complex form of minor neurological dysfunction (cMND). Secondary correlations that were studied were DHA and AA levels with cognitive development in terms of full IQ, and with behavioural development in terms of a total problem score. RESULTS: children, Boys, girls, boys with cMND showed lower DHA values in the umbilical vein than children, Boys, girls, boys with better neurological condition (p=0.033). A similar association was absent in children, Boys, girls, boys . Neonatal AA values were not associated with neurological outcome. Neither neonatal DHA nor AA values were associated with cognition and behaviour at 9. CONCLUSIONS: Higher umbilical DHA levels in children, Boys, girls, boys are associated with better neurological development at 9years. AA status at birth was not associated with neurodevelopment at 9years.
| null |
3092_biomrc
|
Title: Information processing components of the auditory event related potential are reduced by XXXX .
The effects of cocaine on a human electroencephalographic event related potential (ERP) were measured. Forty-eight subjects received one of three IV doses (0.2, 0.4, or 0.6 mg/kg) and placebo. Thirty-three subjects received one of three oral doses (2, 3, or 4 mg/kg). All IV and oral doses reduced amplitude of the auditory ERP human9689 and P300 components during the oddball task. human9689 latency decreased. N100 amplitude was reduced only after IV administration. The changes in ERPs occurred during the period of peak cardiovascular and subjective effects. The amplitude reduction in ERP components occurring before the P300 component is consistent with decrements in attention, specifically selective attention. The P300 amplitude reduction after cocaine suggests a disruption of stimulus evaluation resources. The findings are inconsistent with the notion that stimulants affect only response selection and execution. The degree to which stimulants alter cognitive processes prior to response selection may depend on the magnitude of the cardiovascular, subjective, and probably other noncognitive effects.
| null |
1051_biomrc
|
Title: A text message @entity167 intervention for young adult XXXX @entity1 : a randomized clinical trial.
STUDY OBJECTIVE: Opportunistic brief in- participants, patients, person emergency department, ED ( emergency department, ED ) interventions can be effective at reducing hazardous participants, patients, person67 use in young adult drinkers, but require resources frequently unavailable. Mobile telephone text messaging ( short message service, SMS [ short message service, SMS ]) could sustainably deliver behavioral support to young adult participants, patients, person , but efficacy remains unknown. We report 3-month outcome data of a randomized controlled trial testing a novel short message service, SMS -delivered intervention in hazardous-drinking young adults. METHODS: We randomized 765 young adult emergency department, ED participants, patients, person who screened positive for past hazardous participants, patients, person67 use to one of 3 groups: short message service, SMS assessments+feedback (SA+F) intervention who were asked to respond to drinking-related queries and received real-time feedback through short message service, SMS each Thursday and Sunday for 12 weeks (n=384), short message service, SMS assessments (SA) who were asked to respond to participants, patients, person67 consumption queries each Sunday but did not receive any feedback (N=196), and a control group who did not participate in any short message service, SMS (n=185). Primary outcomes were self-reported number of binge drinking days and number of drinks per drinking day in the past 30 days, collected by Web-based timeline follow-back method and analyzed with regression models. Secondary outcomes were the proportion of participants, patients, person with weekend binge episodes and most drinks consumed per drinking occasion during 12 weekends, collected by short message service, SMS . RESULTS: With Web-based data, there were decreases in the number of self-reported binge drinking days from baseline to 3 months in the SA+F group (-0.51 [95% confidence interval {CI} -0.10 to -0.95]), whereas there were increases in the SA group (0.90 [95% CI 0.23 to 1.6]) and the control group (0.41 [95% CI -0.20 to 1.0]). There were also decreases in the number of self-reported drinks per drinking day from baseline to 3 months in the SA+F group (-0.31 [95% CI -0.07 to -0.55]), whereas there were increases in the SA group (0.10 [95% CI -0.27 to 0.47]) and the control group (0.39 [95% CI 0.06 to 0.72]). With short message service, SMS data, there was a lower mean proportion of SA+F participants, patients, person reporting a weekend binge during 12 weeks (30.5% [95% CI 25% to 36%) compared with the SA participants, patients, person (47.7% [95% CI 40% to 56%]). There was also a lower mean drinks consumed per weekend during 12 weeks in the SA+F group (3.2 [95% CI 2.6 to 3.7]) compared to the SA group (4.8 [95% CI 4.0 to 5.6]). CONCLUSION: A text message intervention can produce small reductions in self-reported binge drinking and the number of drinks consumed per drinking day in hazardous-drinking young adults after emergency department, ED discharge.
| null |
3101_biomrc
|
Title: Transsphenoidal surgery for XXXX in the United States, 1996-2000: mortality, morbidity, and the effects of hospital and surgeon volume.
Larger surgical caseload is associated with better patients, patient outcome for many complex procedures. We examined the volume-outcome relationship for transsphenoidal pituitary tumor surgery using the Nationwide Inpatient Sample, 1996-2000. Multivariate regression adjusted for patients, patient demographics, acuity measures, medical comorbidities, and endocrine status. A total of 5497 operations were performed at 538 hospitals by 825 surgeons. Outcome measured at hospital discharge was: death (0.6%), discharge to long-term care (0.9%), to short-term rehabilitation (2.1%), or directly home (96.2%). Outcomes were better after surgery at higher-volume hospitals (OR 0.74 for 5-fold-larger caseload, P = 0.007) or by higher-volume surgeons (OR 0.62, P = 0.02). A total of 5.4% of patients, patient were not discharged directly home from lowest-volume-quartile hospitals, compared with 2.6% at highest-volume-quartile hospitals. In-hospital mortality was lower with higher-volume hospitals (P = 0.03) and surgeons (P = 0.09). Mortality rates were 0.9% at lowest-caseload-quartile hospitals and 0.4% at highest-volume-quartile hospitals. Postoperative complications (26.5% of admissions) were less frequent with higher-volume hospitals (P = 0.03) or surgeons (P = 0.005). Length of stay was shorter with high-volume hospitals (P = 0.02) and surgeons (P < 0.001). Hospital charges were lower for high-volume hospitals, but not significantly. This analysis suggests that higher-volume hospitals and surgeons provide superior short-term outcomes after transsphenoidal pituitary tumor surgery with shorter lengths of stay and a trend toward lower charges.
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1054_biomrc
|
Title: XXXX segmentation from PET-CT volumes with spatial-topological constraint.
PURPOSE: Accurate lung tumors, better lung tumor, lung cancer, lung tumor segmentation is a prerequisite for effective radiation therapy and surgical planning. However, tumor, tumors delineation is challenging when the tumor, tumors boundaries are indistinct on PET or CT. To address this problem, we developed a segmentation method to improve the delineation of primary lung tumors, better lung tumor, lung cancer, lung tumor from PET-CT images. METHODS: We formulated the segmentation problem as a label information propagation process in an iterative manner. Our model incorporates spatial-topological information from PET and local intensity changes from CT. The topological information of the regions was extracted based on the metabolic activity of different tissues. The spatial-topological information moderates the amount of label information that a pixel receives: The label information attenuates as the spatial distance increases and when crossing different topological regions. Thus, the spatial-topological constraint assists accurate tumor, tumors delineation and separation. The label information propagation and transition model are solved under a random walk framework. RESULTS: Our method achieved an average DSC of [Formula: see text] and lung tumors, better lung tumor, lung cancer, lung tumor033 (mm) of [Formula: see text] on 40 patients with lung tumors, better lung tumor, lung cancer, lung tumor . The t test showed a significant improvement (p value [Formula: see text] 0.05) in segmentation accuracy when compared to eight other methods. Our method was better able to delineate tumor, tumors that had heterogeneous FDG uptake and which abutted adjacent structures that had similar densities. CONCLUSIONS: Our method, using a spatial-topological constraint, provided lung tumors, better lung tumor, lung cancer, lung tumor delineation, in particular, when the tumor, tumors involved or abutted the chest wall and the mediastinum.
| null |
3104_biomrc
|
Title: [The expression and effects of isoforms of macrophage colony stimulating factor in XXXX leukemic cell lines].
OBJECTIVE: To explore the expression and effects of isoforms of M-CSF, macrophage colony-stimulating factor ( M-CSF, macrophage colony-stimulating factor ) in human, Human leukemic cell lines. METHODS: Three normal human, Human peripheral blood mononuclear cells (PBMCs) and 4 human, Human myelomonocytic leukemic cell lines including J6-1, J6-2, K562 and HL-60 were studied using ABC immunoperoxidase assay, indirect immunofluorescence staining, flow cytometry, Western blot and reverse enzyme-linked DNA-protein interaction assay (reverse ELDIA). RESULTS: M-CSF, macrophage colony-stimulating factor was noticed to be localized in the cytoplasm, nucleus and at the cell membrane in 4 human, Human leukemic cell lines; expression of M-CSF, macrophage colony-stimulating factor was not detected in normal human, Human PBMCs without PHA stimulation. human, Human PBMCs stimulated by PHA expressed a low level of M-CSF, macrophage colony-stimulating factor . Frequencies of membrane bound M-CSF, macrophage colony-stimulating factor expression in J6-1, J6-2, K562 and HL-60 were 71.6%, 69.7%, 42.7% and 57.4% respectively. Frequencies of cytoplasm and nucleus associated M-CSF, macrophage colony-stimulating factor were 65.7%, 45.4%, 36.5% and 72.5% respectively. The cytosolic bound M-CSF, macrophage colony-stimulating factor was expressed in J6-1 cell as four isoforms with a molecular weight of 14,000, 16,000, 20,000 and 44,000 . While nucleus associated M-CSF, macrophage colony-stimulating factor expressed as two isoforms with a molecular weight of 16,000 and 20,000. Anti- M-CSF, macrophage colony-stimulating factor monoclonal antibody could dramatically inhibit proliferation of leukemic cells and its inhibitory effect was related to the levels of membrane bound M-CSF, macrophage colony-stimulating factor expression in leukemic cells. Reverse ELDIA showed that M-CSF, macrophage colony-stimulating factor could bind with DNA in vitro. CONCLUSIONS: Expression of M-CSF, macrophage colony-stimulating factor isoforms is heterogeneous and polymorphous in leukemic cells. Membrane bound M-CSF, macrophage colony-stimulating factor is crucial for the proliferation of leukemic cells, which might be a DNA-bound protein and could be involved in the transformation and tumorigenesis of hematopoietic cells.
| null |
3107_biomrc
|
Title: Oral @entity5015 as a therapeutic modality for leg XXXX in Beh et's disease.
Prostaglandin E1, PGE1 ( Prostaglandin E1, PGE1 ) has been generally given only by intravascular injection. Recently, an oral Prostaglandin E1, PGE1 named OP1206 has been developed. OP1206 is a potent inhibitor of humans, patients, patient423 as well as a strong vasodilator, and its half-life in humans, patients, patient is extremely prolonged because it is not metabolized in the lungs. Leg ulceration is one of the cutaneous manifestations in Beh et's disease and sometimes is very difficult to treat. In this investigation five humans, patients, patient having Beh et's disease with leg humans, patients, patient066 were treated with OP1206 . All of the humans, patients, patient had the leg humans, patients, patient066 for more than 2 months. Fifteen micrograms of OP1206 was given initially, and the dosage was increased to 30 micrograms whenever there were no adverse effects. All the humans, patients, patient were soon able to tolerate the drug and increased dosage. Within 2 weeks, regeneration of granulomatous tissues was observed in all cases. Furthermore, the leg humans, patients, patient066 healed within one year. Only one humans, patients, patient developed diarrhoea , but this symptom disappeared when he adjusted to the dosage. The findings strongly indicate that OP1206 is a safe and promising drug for the treatment of leg humans, patients, patient066 in Beh et's disease.
| null |
3108_biomrc
|
Title: XXXX in a prospective cohort of overweight and @entity28 US @entity1 .
Overweight and obese, obesity are associated with increased postmenopausal breast cancer, weight loss and postmenopausal breast cancer risk; however, it is unclear whether losing excess weight will lower risk. Therefore, we examined the relationship between postmenopausal breast cancer, weight loss and postmenopausal breast cancer among 13,055 overweight and obese, obesity , cancer, Cancer -free women who enrolled in the cancer, Cancer Prevention Study-II (CPS-II) Nutrition Cohort in 1992. During the 15 year follow-up, 816 postmenopausal breast cancer, weight loss and postmenopausal breast cancer cases were diagnosed. Self-reported weight was collected before diagnosis at baseline and 10 years prior to baseline. The median weight loss was 11 lbs, but only 58% of the women maintained this weight loss through the first 5 year follow-up interval (1992-1997). Using both restricted cubic splines and multivariate Cox proportional hazards modeling, we observed no association between postmenopausal breast cancer, weight loss and postmenopausal breast cancer . The hazard ratio for 30+ pounds of weight loss compared to stable weight was 0.95 (95%: CI 0.47-1.95). An inverse association was, however, suggested among women who maintained ten or more pounds of weight loss through the next interval. There was no evidence of effect modification by postmenopausal hormone use, initial BMI, or other factors examined. In summary, weight loss was not associated with postmenopausal breast cancer, weight loss and postmenopausal breast cancer in this study. Future studies should focus on sustained weight loss and whether the timing of weight loss is important.
| null |
3116_biomrc
|
Title: Cryoablative techniques in the treatment of XXXX .
Of 175 patients, patient, infants treated surgically for potentially lethal or refractory cardiac tachyarrhythmias , 53 underwent mapping and definitive operation using cryoablative techniques as the primary or adjunctive method. Included were 16 patients, patient, infants with supraventricular tachycardia caused by accessory pathways ( Kent bundle ) in the right anterior or posterior paraseptal location. Cryoablation was successful in abolishing Purkinje cell tumor91 in 93.7% (15 of 16). Six patients, patient, infants (100%) with permanent junctional reciprocating Purkinje cell tumor91 were cured by cryoablation. Eighteen of 19 patients, patient, infants with atrial ectopic focus, atrial ectopic tachycardia were treated by cryoablation alone or in combination with excision of the atrial appendage , with success in 15 (83.3%). Five of these were left atrial foci cured by cryoablation. Fourteen right atrial foci were treated by excision of the appendage only (1 patients, patient, infants ), excision of the appendage and local cryoablation (8 patients, patient, infants ), and cryoablation alone (5 patients, patient, infants ). Three of these underwent partial (2 patients, patient, infants ) or complete (1 patients, patient, infants ) atrial disconnection after excisional and cryoablative techniques failed to control the Purkinje cell tumor91 . Multiple ectopic atrial foci were common (9 patients, patient, infants ), and successful cryoablation was accomplished in 100% of the patients, patient, infants with a single atrial ectopic focus, atrial ectopic tachycardia (10 patients, patient, infants ) but in only 66% of those with multiple foci. Thirteen of 19 patients, patient, infants with critical patients, patient, infants165 were treated by cryoablation at the site of the ectopic focus, either alone or in combination with excision of the area. Elimination of Purkinje cell tumor91 was accomplished in 13 patients, patient, infants (100%). Myocardial hamartoma ( Purkinje cell tumor ) was the histological diagnosis in 11 of the patients, patient, infants with patients, patient, infants165 .(ABSTRACT TRUNCATED AT 250 WORDS)
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1068_biomrc
|
Title: Biomechanical and cellular segmental characterization of XXXX meniscus: building the basis for Tissue Engineering therapies.
OBJECTIVE: To overcome current limitations of Tissue Engineering (TE) strategies, deeper comprehension on meniscus biology is required. This study aims to combine biomechanical segmental analysis of fresh human meniscus tissues and its correlation with architectural and cellular characterization. METHOD: Morphologically intact menisci, from 44 live donors were studied after division into three radial segments. Dynamic mechanical analysis (DMA) was performed at physiological-like conditions. Micro-computed tomography (CT) analysis of freeze-dried samples assessed micro-structure. Flow cytometry, histology and histomorphometry were used for cellular study and quantification. RESULTS: Anterior segments present significantly higher damping properties. Mid body fresh medial meniscus presents higher values of E' compared to lateral. Cyclic loads influence the viscoelastic behavior of menisci. By increasing the frequency leads to an increase in stiffness. Conversely, with increasing frequencies, the capacity to dissipate energy and damping properties initially decrease and then rise again. Age and gender directly correlate with higher E' and tan . Micro-CT analysis revealed that mean porosity was 55.5 (21.2-89.8)% and 64.7 (47.7-81.8)% for freeze-dried lateral and medial meniscus, respectively. Predominant cells are positive for human759 , human2359 , CD90 and CD105, and lack CD31 , CD34 and human195 (present in smaller populations). Histomorphometry revealed that cellularity decreases from vascular zone 1 to zone 3. Anterior segments of lateral and medial meniscus have inferior cellularity as compared to mid body and posterior ones. CONCLUSION: Menisci are not uniform structures. Anterior segments have lower cellularity and higher damping. Cyclic loads influence viscoelastic characteristics. Future TE therapies should consider segmental architecture, cellularity and biomechanics of fresh tissue.
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1070_biomrc
|
Title: Intraperitoneal XXXX due to spontaneous @entity96 with particular reference to hepatic artery ligation.
During 1970-1976, 459 cases of primary carcinoma of the liver were admitted to the Department of Medicine, Siriraj Hospital, Thailand. Three hundred and two cases (66%) had associated cirrhosis . Fifty-five cases or 12 per cent presented with patients, patient8767 from ruptured carcinomatous nodules . In most of these, the presenting symptom were not dramatic and might be indistinguishable from other uncomplicated carcinoma of the liver . Only 2 cases presented as acute abdomen and 5 cases had severe abdominal pain for short duration prior to admission. Peritonoscopy were performed routinely in all cases with patients, patient8767 except the two cases which presented as acute abdomen. Fifty cases or 91 per cent had associated cirrhosis and the site of the rupture were visualized in 6 cases or 11.32 per cent. Fourteen patients, patient were treated conservatively with the mortality rate of 100 per cent. Eight patients, patient who presumably bled from coagulation defect were also treated conservatively with only 50 per cent mortality. Hepatic artery ligation was employed in 23 cases with 52 per cent mortality and bleeding, hemorrhage stopped in 95 per cent, as compare with other conventional surgical measure such as packing, suture and cauterization to control the bleeding, hemorrhage with 90 per cent mortality. Judging from our experience, hepatic artery ligation is of definite value for palliative treatment particularly in patients, patient with patients, patient8767 from ruptured carcinoma of the liver .
| null |
1072_biomrc
|
Title: XXXX as a cause of chronic @entity8442 : A case report and literature review.
patient0478 is one of the causes of chronic intestinal pseudo-obstruction . Most cases pathologically reveal patient79 or muscularis propia patient94 and fibrosis . Abnormal layering of muscularis propria is extremely rare. We report a case of a 9-mo-old Thai male baby who presented with chronic intestinal pseudo-obstruction . Histologic findings showed abnormal layering of small intestinal muscularis propria with an additional oblique layer and aberrant muscularization in serosa. The patient also had a short small bowel without patient518 , patient4883 , and absence of the 2(nd) to 4(th) middle phalanges of both hands. The patient was treated with cisapride and combined parenteral and enteral nutritional support. He had gradual clinical improvement and gained body weight. Subsequently, the parenteral nutrition was discontinued. The previously reported cases are reviewed and discussed.
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3123_biomrc
|
Title: A novel hypothesis for @entity731 as a XXXX deficiency syndrome.
BACKGROUND: Despite a vast literature, atherosclerosis and the associated ischemia /reperfusion injuries remain today in many ways a mystery. Why do atheromatous plaques, atheromas make and store a supply of cholesterol and sulfate, Sulfate within the major arteries supplying the heart? Why are treatment programs aimed to suppress certain myocardial infarction risk factors, such as elevated serum homocysteine and inflammation , generally counterproductive? METHODS: Our methods are based on an extensive search of the literature in atherosclerotic cardiovascular disease as well as in the area of the unique properties of water, the role of biosulfates in the vascular wall, and the role of electromagnetic fields in vascular flow. Our investigation reveals a novel pathology linked to atherosclerosis that better explains the observed facts than the currently held popular view. RESULTS: We propose a novel theory that atherosclerosis can best be explained as being due to cholesterol sulfate deficiency. Furthermore, atheromatous plaques, atheromas replenish the supply of cholesterol and sulfate, Sulfate to the microvasculature, by exploiting the inflammatory agent superoxide to derive sulfate, Sulfate from homocysteine and other sulfur sources. We argue that the sulfate, Sulfate anions attached to the glycosaminoglycans in the glycocalyx are essential in maintaining the structured water that is crucial for vascular endothelial health and erythrocyte mobility through capillaries. sulfate, Sulfate depletion leads to cholesterol accumulation in atheromatous plaques, atheromas , because its transport through water-based media depends on sulfurylation. We show that streaming potential induces nitric oxide, nitric-oxide (NO) release, and NO derivatives break down the extracellular matrix, redistributing sulfate, Sulfate to the microvasculature. We argue that low (less negative) zeta potential due to insufficient sulfate, Sulfate anions leads to hypertension and thrombosis , because these responses can increase streaming potential and induce nitric oxide, nitric-oxide mediated vascular relaxation, promoting oxygen delivery. Our hypothesis is a parsimonious explanation of multiple features of atherosclerotic cardiovascular disease . CONCLUSIONS: If our interpretation is correct, then it would have a significant impact on how atherosclerosis is treated. We recommend a high intake of sulfur -containing foods as well as an avoidance of exposure to toxicants that may impair sulfate, Sulfate synthesis.
| null |
1080_biomrc
|
Title: XXXX mimic clear cell carcinoma.
INTRODUCTION: children, woman, patient9967 are quite unusual lesions that represent less than 3% of all teratomas and its malignant transformation is very uncommon. The clinical manifestations are characteristic of pelvic tumor and the hormonal metabolism is not usually modified. Radiography, employing ultrasound procedures, is the most commonly used pre-surgical detection method but only histological examination makes the diagnosis. The malignance recognition by pathological study not always is easy; in this sense, it requires an exhaustive sampling of the lesion, being specially carefully in some aspects related with malignant transformation such as extending beyond the capsula and involving peripheral tissues. A thyroidal differentiation must be confirmed by immunohistochemical study and other local processes with similar histology should be ruled out. Given the exceptional character of malignant forms, there does not appear to be unanimous agreement on a standard therapy with a somewhat uncertain prognosis. CASE REPORT: We show a case of a 22-year-old children, woman, patient with an ovarian tumor that was discovered by ultrasound examination and surgically removed. The histologic study revealed children, woman, patient9967 with children, woman, patient89 and unlike previously published cases, had a prevalence of clear cells. The children, woman, patient was submitted to a second surgical staging intervention, with conservative surgery and follow-up controls being considered given that was a young children, woman, patient with a desire to have children, woman, patient . Laparoscopy was employed as the best method capable to facilitate shorter convalescence. OUTCOME: Clinical and analytical controls, measuring thyroglobulin levels, has been satisfactory up to the present.
| null |
3133_biomrc
|
Title: Microsurgical treatment of large and XXXX .
BACKGROUND: patients823 ( patients823 ) are benign, highly vascularized lesions located in the jugular foramen with frequent invasion to the temporal bone, the upper neck, and the posterior fossa cavity. Their natural history, surgical treatment, and outcome have been well addressed in the recent literature; however, there is no consensus regarding the optimal management while minimizing treatment-related morbidity. In this study, we assessed the interdisciplinary microsurgical treatment and outcome of large TJP collected at a single center. METHODS: Out of 54 patients with skull base patients823 , 14 (25%) presented with large TJP (Fisch grade C and D). Posterior fossa involvement was present in 10 patients (Fisch D). Eleven patients presented with hearing loss , two patients with mild facial nerve palsy , and two patients with lower patients29 . Two other patients with previous surgery presented with tumor, Radical tumor regrowth. RESULTS: Preoperative embolization was performed in 13 cases. tumor, Radical tumor removal was possible in 10 patients . Hearing was preserved in four patients with normal preoperative audiogram. The facial nerve was preserved in all patients . Temporary facial nerve palsy occurred in two patients and resolved in long-term follow-up. In three patients , preexisting facial nerve palsy remained unchanged. Persistent vocal cord palsy was present in three patients and was treated with laryngoplasty. The global recovery based on the Karnofsky performance scale was 100% in 10 patients and 90% in 4 patients . CONCLUSION: Preoperative embolization and interdisciplinary microsurgical resection are the preferred treatment for selected patients due to high tumor, Radical tumor control rates and good long-term results.
| null |
1087_biomrc
|
Title: Dietary XXXX supplementation enhances intestinal development and expression of vascular endothelial growth factor in weanling piglets.
Oral administration of L-arginine has been reported to prevent gut disease in human, infants human, infants . However, little is known about the effects of dietary arginine, Arginine supplementation on intestinal development of weaned piglets. In the present study, twenty 21-d-old castrated piglets with 5 3 (SEM 0 13) kg body weight (BW) were weaned from sows, individually housed and randomly assigned to one of the two maize - and soyabean meal-based diets supplemented with 0 or 1% L-arginine . After consuming the diets for 7 d, six human, infants707 were randomly selected from each group to obtain various tissues. Compared with control human, infants707 , dietary supplementation with 1% L-arginine did not affect feed intake but enhanced (P<0 05) the relative weight of the small intestine (+33 %), daily BW gain (+38 %) and feed efficiency (+28 %). The villus height of the duodenum, jejunum and ileum in arginine, Arginine -supplemented piglets was 21, 28 and 25% greater (P<0 05) than in the nonsupplemented control group. arginine, Arginine supplementation increased (P<0 05) protein levels for vascular endothelial growth factor( human, infants7980 ) in duodenal, jejunal and ileal mucosae by 14, 39 and 35 %, respectively. Compared with the control group, dietary supplementation with 1% L-arginine increased (P<0 05) plasma concentrations of arginine, Arginine and insulin (+36 %), and decreased (P<0 05) plasma concentrations of cortisol (233 %), NH3 (221 %) and human, infants133 (219 %). These results indicate that arginine, Arginine supplementation enhances intestinal growth, development and expression of human, infants7980 in early-weaned human, infants707 fed a maize - and soyabean meal-based diet. The findings may have important implications for neonatal human, infants707 under stressful or diseased conditions.
| null |
3137_biomrc
|
Title: Accuracy of Magnetic Resonance Imaging for Local Staging of XXXX : A Diagnostic Meta-analysis.
CONTEXT: Correct assessment of tumours, tumour stage is crucial for prostate cancer, PCa ( prostate cancer, PCa ) management. OBJECTIVE: To assess the diagnostic accuracy of magnetic resonance imaging (MRI) for local prostate cancer, PCa staging and explore the influence of different imaging protocols. EVIDENCE ACQUISITION: We searched the PubMed, Embase, and Cochrane databases from 2000 up to August 2014. We included studies that used MRI for detection of extracapsular extension (ECE; T3a), seminal vesicle invasion, SVI ( seminal vesicle invasion, SVI ; T3b), or overall stage T3 prostate cancer, PCa , with prostatectomy as the reference standard. Methodologic quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies tool by two independent reviewers. Data necessary to complete 2*2 tables were obtained, and patients, patient, PATIENT , study, and imaging characteristics were extracted. Accuracy was reported for the most experienced or first reader. Results were pooled and plotted in summary receiver operating characteristics plots. EVIDENCE SYNTHESIS: A total of 75 studies (9796 patients, patient, PATIENT ) could be analysed. Pooled data for ECE (45 studies, 5681 patients, patient, PATIENT ), seminal vesicle invasion, SVI (34 studies, 5677 patients, patient, PATIENT ), and overall stage T3 detection (38 studies, 4001 patients, patient, PATIENT ) showed sensitivity and specificity of 0.57 (95% confidence interval [CI] 0.49-0.64) and 0.91 (95% CI 0.88-0.93), 0.58 (95% CI 0.47-0.68) and 0.96 (95% CI 0.95-0.97), and 0.61 (95% CI 0.54-0.67) and 0.88 (95% CI 0.85-0.91), respectively. Functional imaging in addition to T2-weighted imaging and use of higher field strengths (3 T) improved sensitivity for ECE and seminal vesicle invasion, SVI . ECE sensitivity was not improved by endorectal coil use. CONCLUSIONS: MRI has high specificity but poor and heterogeneous sensitivity for local prostate cancer, PCa staging. An endorectal coil showed no additional benefit for ECE detection, but slightly improved sensitivity for seminal vesicle invasion, SVI detection. Higher field strengths and the use of functional imaging techniques can slightly improve sensitivity. patients, patient, PATIENT SUMMARY: We pooled the results from all previous studies that evaluated magnetic resonance imaging (MRI) for detection of tumours, tumour growth outside the prostate. MRI is not sensitive enough to find all tumours, tumour with extraprostatic growth.
| null |
1089_biomrc
|
Title: Acute activation of XXXX cannabinoid receptors transiently decreases PSA-NCAM expression in the dentate gyrus of the @entity35 hippocampus.
Recent evidence indicates that the polysialylated neural cell adhesion molecule (PSA-NCAM) is involved in hippocampal plasticity. On the other hand, CB1 receptor activation is known to disturb some hippocampal processes involving plastic changes, such as learning and memory. Therefore, the present study investigated the effect of HU-210 , a CB1 receptor agonist, on the expression of PSA-NCAM protein in the dentate gyrus (DG) and CA3 region of the rat hippocampus. It was found that at a dose of 0.1 mg/kg i.p. of HU-210 , the number of PSA-NCAM immunoreactive (IR) cells in the DG declined in a time-dependent manner. The decrease in PSA-NCAM expression was observed at 1 and 2 days (ca. 21% and 30%, respectively), but not after 4 h and 4 days following HU-210 administration. However, HU-210 treatment did not change the length density of PSA-NCAM immunopositive processes in CA3 mossy fibers at all the time points measured. The effect observed in the DG on day 2 was blocked by AM-251 (1 mg/kg, i.p.), a CB1 receptor antagonist, given 30 min before HU-210 . Neither the number of Ki-67 (IR) cells (a marker of proliferation) nor the number of doublecortin-IR cells (a marker of immature neurons) was affected by HU-210 (0.1 mg/kg, i.p.) treatment at any of the time points. An analysis of co-localization of CB1 receptor protein with PSA-NCAM protein revealed that both proteins were not present in the same population of neurons in the subgranular layer of the DG. The observed changes in PSA-NCAM expression were not related to the reduction of proliferation or differentiation of newly born cells, but were possible due to alternations in the synaptic activity in the DG. However, such alteration in the PSA-NCAM expression may change the timing of the functional maturation of newly born neurons. Moreover, the above finding suggests that acute activation of CB1 receptors may result in the stiffening of the hippocampal structure and susceptibility to plastic changes and may lead to functional impairment governed by alterations in the hippocampal structure.
| null |
3142_biomrc
|
Title: Fractionated stereotactic radiotherapy for large and invasive non-functioning XXXX : long-term clinical outcomes and volumetric MRI assessment of @entity5 response.
UNASSIGNED: Design: Fractionated stereotactic radiotherapy (FSRT) is frequently employed for the treatment of residual or recurrent pituitary adenomas . We describe our use of FSRT for the treatment of large, invasive, nonfunctioning pituitary adenomas (NFPAs). Methods: Sixty-eight patients with a large residual or recurrent NFPAs were treated between April 2004 and December 2012, including 39 males and 29 females (median age 51 years). Visual defects, visual field defects were present in 34 patients , consisting of Visual defects, visual field defects (n=31) and/or reduced visual acuity (n=12). Forty-five patients had evidence of partial or total hypopituitarism, partial or complete hypopituitarism before FSRT. For most of the patients , the treatment was delivered through 5-10 noncoplanar conformal fixed fields using a 6-MV linear accelerator to a dose of 45 Gy in 25 fractions. Results: At a median follow-up of 75 months (range 12-120 months), the 5-year and 10-year actuarial local control were 97% and 91%, respectively, and overall survival 97% and 93%, respectively. Forty-nine patients had a tumor reduction, 16 remained stable, and 3 progressed. The relative tumor volume reduction measured using three-dimensional (3-D) magnetic resonance imaging (MRI) was 47%. The treatment was well tolerated with minimal acute patients37 . Eighteen patients developed partial or total hypopituitarism, partial or complete hypopituitarism . The actuarial incidence of new anterior pituitary deficits was 40% at 5 years and 72% at 10 years. No other radiation-induced complications occurred. Conclusions: Our results suggest that FSRT is an effective treatment for large or giant pituitary adenomas with patients37 .
| null |
3144_biomrc
|
Title: Prognostic factors and risk group analysis in follicular XXXX .
BACKGROUND: The understanding of prognostic factors has facilitated stratification of risk groups in differentiated thyroid carcinoma, carcinoma of the thyroid . The prognostic factors have clearly identified the risk groups as low, intermediate, and high risk. Risk group categorization has facilitated a selective surgical approach for thyroid carcinoma, carcinoma of the thyroid . METHODS: A retrospective review of 228 Patients, patients with follicular thyroid carcinoma, carcinoma of the thyroid was undertaken. Various prognostic factors and risk groups were analyzed. Univariate and multivariate analyses were performed, and the survival curves were plotted by the Kaplan-Meier method. Fifty-nine (26%) Patients, patients presented with H rthle cell histology. The risk groups revealed 62 Patients, patients in the low, 84 in the intermediate, and 82 in the high risk groups. RESULTS: The 10-year survival for low, intermediate, and high risk groups was 98%, 88%, and 56%, respectively, and the 20-year survival for the same groups was 97%, 87%, and 49%, respectively. Adverse prognostic factors included age older than 45 years (p < 0.001), H rthle cell variety (p = 0.05), extrathyroidal extension, tumor size exceeding 4 cm, and the presence or absence of distant metastasis (p < 0.001). Gender, focality, and presence of lymph node metastasis had no significant impact on prognosis. CONCLUSIONS: Patients, patients in the low risk group have excellent survival, whereas the high risk group behaves poorly. Appropriate selection of treatment for the primary disease and adjuvant therapy should be considered on the basis of the prognostic factors and risk group analysis.
| null |
1097_biomrc
|
Title: Direct cellular interaction with activated XXXX (+) T cells overcomes @entity6306 of @entity1072 in vitro.
The proliferative response of clonal B cells from patients with patients072 ( patients072 ) is drastically reduced compared to normal B lymphocytes stimulated via the B cell antigen receptor complex or by CD40 ligation. In the present study we demonstrate that hyporesponsiveness of CLL-B cells can be overcome by stimulatory pathways mediated by activated CD4 (+) T cells. In contrast to CD40 ligation, costimulation with activated T cells promotes a proliferative response in CLL-B cells identical to that in normal B cells. Furthermore, coculture with activated T cells improved survival of CLL-B cells in vitro. Differentiation of CLL-B cells into IgM producing cells was promoted, as well. However, the capacity for IgM secretion remained impaired compared to that of normal B cells. For T-cell-mediated B cell activation direct cellular contact with activated T helper cells is absolutely required. Prevention of CD40 / patients1603 interaction by CD40 antibody caused only partial inhibition of B cell activation, suggesting that additional signals are involved in T-B cell interaction. Whereas interruption of the ligand pairs patients453 / CD54 , CD5 / CD72 , CD27 / CD70 had no influence, the addition of CD58 antibody completely inhibited B cell activation by activated T cells. In costimulation with cellular signals the presence of B-cell-tropic cytokines, such as patients199 and IL-4 , was required to optimize patients072 proliferation, as demonstrated by the use of neutralizing antibodies. We conclude from these results that proliferative hyporesponsiveness by CLL-B cells can be circumvented by antigen-nonspecific signals in addition to CD40 which are mediated by direct contact with activated T helper cells.
| null |
3145_biomrc
|
Title: Longer survival and fewer metastases by @entity7305 and tegafur in XXXX -induced murine @entity694 .
The anticancer effects of levamisole , tegafur and their combination were experimentally compared in rats on the 1, 2-dimethylhydrazine ( DMH )-induced colonic cancers . DMH at 20 mg/kg of body weight was injected subcutaneously to Donryu rats once a week for 24 weeks long. Nineteen weeks after the start of DMH administration, early colonic cancers were induced and, 28 weeks after, they developed into advanced cancers, early cancer with distant metastases. From 19 weeks after the start of DMH injection, subcutaneous administration of levamisole at the dose of 2 mg/kg, oral administration of tegafur at 90 mg/kg and their combination were given to the rats daily for nine weeks. The animals were sacrificed 28 weeks after the start of DMH administration. Tegafur was effective, but levamisole with or without tegafur was not effective against cancers, early cancer . From 28 weeks after the start of DMH injection, levamisole , tegafur and their combination were administered to the rats daily for four weeks. All of the rats were necropsied when they died. The survival rate and mean survival days were significantly higher and longer in the levamisole groups than in the control rats (p less than 0.05). The incidence of distant metastases was also significantly lower in the levamisole groups than in the control group.
| null |
3146_biomrc
|
Title: Adjuvant @entity1499 escalated to @entity137 for resectable stage III and IV XXXX --a prospective, randomized study.
To determine if adjuvant patients, patient499 ( patients, patient500 ), escalated weekly to patients, patient37 , could improve disease-free survival (DFS) and overall survival by preventing recurrent disease, 60 patients, patient with potentially resectable stage III or IV squamous head and neck carcinomas were stratified by primary site, stage, and nutritional status, then randomized by pairs to receive or not receive adjuvant patients, patient500 . All received standard surgery and postoperative radiation therapy. Five patients, patient were taken off study because of unresectability at the time of surgery, leaving 55 evaluable patients, patient . There were no statistically significant imbalances in known prognostic factors between the two treatment arms. patients, patient500 was begun at 40 mg/m2 and escalated 10 mg/m2 weekly (four doses preoperatively; four doses postoperatively, preradiation therapy; eight doses postradiation therapy) to mucosal or hematologic patients, patient37 . The median peak patients, patient500 dose achieved was 80 mg/m2. Although three patients, patient were hospitalized with patients, patient500 patients, patient37 , none died of patients, patient500 patients, patient37 . No patients, patient receiving patients, patient500 had disease progression during treatment, and there was no increase in postoperative complications . Thirty-two patients, patient died (median survival, 19 months); 23 patients, patient are alive with median follow-up of 43 months. There was no statistically significant difference in actuarial DFS (P = 1.0) or overall survival (P = .61). Although patients, patient on the patients, patient500 arm appeared to have less local and regional recurrences at first recurrence (thus more distant metastases), this did not reach statistical significance (P = .06). There was no significant difference between the sites of recurrence at death or last follow-up (P = .38).
| null |
1100_biomrc
|
Title: Early evaluation of @entity1740 in XXXX (T1, T2) following curative radiotherapy.
BACKGROUND: This is prospective study analyzing the subjective and objective quality of voice and voice related quality of life in patients, patient of early glottic cancer (T1, T2 disease) before and after receiving curative radiotherapy. METHODS: Fifteen patients, patient of early patients, patient89 (T1, T2) underwent voice assessment using multidimensional voice protocol based on recommendation by European Laryngological Society which included Perceptual analysis of voice by speech therapist and otolaryngologist, acoustic analysis; aerodynamic efficiency analysis-Maximum phonation time; patients, patient 's self perception of voice analysis--Voice handicap index; and videolaryngostroboscopy. Assessment was done prior to commencement of radiation therapy and at 1 month and 3 months following radio- therapy. RESULTS: There was significant improvement in majority of the voice parameters post radiotherapy. Perceptual analysis showed significant improvement in GRBAS score following radiotherapy. Perturbation measures (jitter, shimmer, SNR, HNR) showed improvement post radiotherapy though remained inferior compared to controls. Mean fundamental frequency (Mean F0) and habitual frequency (habitual F0) decreased post radiotherapy. Intensity of voice increased following radiotherapy which was statistically significant (p < 0.05). There was significant improvement in the patients, patient 's perception of their quality of voice and voice related quality of life post radiotherapy. Maximum phonation time showed statistically significant improvement post-radiotherapy. Perceptual analysis of voice by professional observer correlated well with patients, patient self perception of his own voice. CONCLUSION: Voice quality improves following radiotherapy but not all the patients, patient regain normal voice. Improvement in patients, patient740 improves quality of life of patients, patient shown by improved voice handicap index.
| null |
3162_biomrc
|
Title: Factors influencing the immediate and late outcome of @entity699 treated by transsphenoidal surgery: a retrospective study by the European XXXX Survey Group.
Hypercortisolism, "Cushings disease", hypercortisolism attributable to hypersecretion of ACTH by a pituitary adenoma is an uncommon and progressively lethal disease. Because of its rarity, it has been difficult to collect a large series of Patients, patients in order to identify the prognostic factors influencing the outcome after transsphenoidal surgery. We conducted a multicenter, retrospective analysis of the early and late results of surgical treatment of Hypercortisolism, "Cushings disease", hypercortisolism . Files of Patients, patients with Hypercortisolism, "Cushings disease", hypercortisolism who underwent transsphenoidal surgery between 1975 and 1990 were collected from 25 institutions throughout Europe. Data from 668 of 716 Patients, patients were suitable for statistical analyses. Surgical mortality was 1.9%, and major morbidity occurred in 97 Patients, patients (14.5%). Clinical and biochemical remission of Hypercortisolism, "Cushings disease", hypercortisolism after surgery occurred in 510 cases (76.3%). Identification of the tumor by neuroradiological imaging or at operation with histopathological corroboration was associated with remission of Hypercortisolism, "Cushings disease", hypercortisolism . Recurrence of the disease occurred in 65 (12.7%) of 510 Patients, patients in remission after surgery at a mean time of 39.3 months (range 6-104 months). The distribution of the recurrences did not show any apparent plateau or cluster throughout the follow-up period. Low postoperative Patients, patients34 levels, absence of cortisol response to CRH , and the need for long-term glucocorticoid substitution therapy were all associated with a high probability of long-term remission. Our study demonstrates that transsphenoidal surgery is a safe and effective treatment for Patients, patients with Hypercortisolism, "Cushings disease", hypercortisolism . However, after successful surgery there is a steady increase in the percentage of recurrences, which continues with time. Patients, patients who after operation had tumor09 and needed long-term glucocorticoid substitution therapy had the lowest risk of relapse.
| null |
1117_biomrc
|
Title: A cross-sectional study of 'yaws' in districts of ghana which have previously undertaken @entity4580 mass drug administration for XXXX control.
Yaws, caused by children, Children4329 ssp. pertenue, is reportedly endemic in Ghana. Mass distribution of azithromycin is now the cornerstone of the WHO yaws eradication campaign. Mass distribution of azithromycin at a lower target dose was previously undertaken in two regions of Ghana for the control of children, Children1738 . Ongoing reporting of yaws raises the possibility that resistance may have emerged in children, Children4329 pertenue, or that alternative infections may be responsible for some of the reported cases. We conducted a cross-sectional survey in thirty communities in two districts of Ghana where MDA for children, Children1738 had previously been conducted. children, Children aged 5-17 years with children, Children066 compatible with yaws were enrolled. Samples for treponemal serology and lesion PCR were collected from all children, Children . 90 children, Children with 98 lesions were enrolled. Syphilis serology was negative in all of them. PCR for children, Children4329 ssp pertenue was negative in all children, Children , but H. ducreyi, Haemophilus ducreyi DNA was detected in 9 lesions. In these communities, previously treated for children, Children1738 , we found no evidence of ongoing transmission of yaws. H. ducreyi, Haemophilus ducreyi was associated with a proportion of skin lesions , but the majority of lesions remain unexplained. Integration of diagnostic testing into both pre and post- children, Children865 surveillance systems is required to better inform yaws control programmes.
| null |
1118_biomrc
|
Title: Prevention of duodenal @entity1066 relapse with XXXX 20 mg daily: a randomized double-blind, placebo-controlled study.
We report the first double-blind, placebo-controlled study that assesses the efficacy and safety of omeprazole, Omeprazole 20 mg daily in the maintenance treatment of duodenal Patients, patients066 . For the healing phase, 128 Patients, patients with endoscopically proven active duodenal Patients, patients066 and a history of three or more relapses during the 2 years prior to the study were treated until healing with omeprazole, Omeprazole 40 mg daily for 2 and up to 8 weeks. One hundred and twenty-three Patients, patients whose Patients, patients066 were healed were randomized to receive omeprazole, Omeprazole 20 mg daily (n = 60) or placebo (n = 63) for 12 months as maintenance treatment. Patients, patients were interviewed at 3, 6, 9 and 12 months, and endoscopy was performed at 3, 6 and 12 months and whenever symptoms recurred. The healing rates of the 124 Patients, patients completing the healing phase were 84, 98 and 100% at 2, 4 and 8 weeks, respectively. During the maintenance phase, eight and four Patients, patients discontinued treatment from the omeprazole, Omeprazole and placebo groups, respectively. The proportion of Patients, patients in remission in the omeprazole, Omeprazole group and placebo group after 12 months were 94 and 9% respectively (life table estimates, P < 0.0001). No significant clinical or laboratory changes were observed in Patients, patients on therapy with omeprazole, Omeprazole . Patients, patients with a history of frequent relapses thus continued to have a very high relapse rate without prophylactic treatment. omeprazole, Omeprazole 20 mg daily was effective and safe in maintaining such Patients, patients in remission.
| null |
3167_biomrc
|
Title: Astrocytes Are Primed by Chronic Neurodegeneration to Produce Exaggerated Chemokine and Cell Infiltration Responses to Acute Stimulation with the Cytokines @entity635 and XXXX .
Microgliosis and astrogliosis are standard pathological features of neurodegeneration, neurodegenerative disease, chronic neurodegenerative disease . Microglia are primed by chronic neurodegeneration, neurodegenerative disease, chronic neurodegenerative disease such that toll-like receptor agonists, such as LPS , drive exaggerated cytokine responses on this background. However, sterile inflammatory insults are more common than direct CNS infection in the degenerating brain and these insults drive robust IL-1b and TNF-a responses. It is unclear whether these pro-inflammatory cytokines can directly induce exaggerated responses in the degenerating brain. We hypothesized that glial cells in the hippocampus of animals with neurodegeneration, neurodegenerative disease, chronic neurodegenerative disease ( ME7 prion disease ) would display exaggerated responses to central cytokine challenges. TNF-a or IL-1b were administered intrahippocampally to ME7-inoculated mice and normal brain homogenate-injected (NBH) controls. Both IL-1b and TNF-a produced much more robust IL-1b synthesis in ME7 than in NBH animals and this occurred exclusively in microglia. However, there was strong nuclear localization of the NFkB subunit p65 in the astrocyte population, associated with marked astrocytic synthesis of the chemokines CXCL1 and CCL2 in response to both cytokine challenges in ME7 animals. Conversely, very limited expression of these chemokines was apparent in NBH animals similarly challenged. Thus, astrocytes are primed in the degenerating brain to produce exaggerated chemokine responses to acute stimulation with pro-inflammatory cytokines. Furthermore, this results in markedly increased neutrophil, T-cell, and monocyte infiltration in the diseased brain. These data have significant implications for acute sterile inflammatory insults such as stroke and traumatic brain injury occurring on a background of aging or neurodegeneration, neurodegenerative disease, chronic neurodegenerative disease .
| null |
3171_biomrc
|
Title: Demography, disease and the devil: life-history changes in a disease-affected population of XXXX ( @entity22337 ).
1. Examining the demographic responses of populations to disease epidemics and the nature of compensatory responses to perturbation from epidemics is critical to our understanding of the processes affecting population dynamics and our ability to conserve threatened species. Such knowledge is currently available for few systems. 2. We examined changes to the demography and life-history traits of a population of Tasmanian devils, Sarcophilus harrisii ( Tasmanian devils, Sarcophilus harrisii ) following the arrival of a debilitating infectious diseases, infectious disease , devil facial tumour disease, DFTD ( devil facial tumour disease, DFTD ), and investigated the population's ability to compensate for the severe population perturbation caused by this epizootic. 3. There was a significant change to the age structure following the arrival of devil facial tumour disease, DFTD to the Freycinet Peninsula. This shift to a younger population was caused by the loss of older individuals from the population as a direct consequence of devil facial tumour disease, DFTD -driven declines in adult survival rates. 4. Offspring sex ratios of disease mothers were more female biased than those of healthy mothers, indicating that devils may facultatively adjust offspring sex ratios in response to disease-induced changes in maternal condition. 5. We detected evidence of reproductive compensation in response to disease impacts via a reduction in the age of sexual maturity of females (an increase in precocial breeding) over time. 6. The strength of this compensatory response appeared to be limited by factors that constrain the ability of individuals to reach a critical size for sexual maturity in their first year, because of the time limit dictated by the annual breeding season. 7. The ongoing devastating impacts of this disease for adult survival and the apparent reliance of precocial breeding on rapid early growth provide the opportunity for evolution to favour of this new life-history pattern, highlighting the potential for novel infectious diseases, infectious disease to be strong selective forces on life-history evolution.
| null |
1127_biomrc
|
Title: Alloimmunization is associated with older age of transfused red blood cells in XXXX .
UNASSIGNED: Red blood cell (RBC) alloimmunization is a significant clinical complication of SCD, sickle cell disease ( SCD, sickle cell disease ). It can lead to difficulty with cross-matching for future transfusions and may sometimes trigger life-threatening delayed hemolytic transfusion reactions. We conducted a retrospective study to explore the association of clinical complications and age of RBC with alloimmunization in patients, patient with SCD, sickle cell disease followed at a single institution from 2005 to 2012. One hundred and sixty six patients, patient with a total of 488 RBC transfusions were evaluated. Nineteen patients, patient (11%) developed new alloantibodies following blood transfusions during the period of review. The median age of RBC units was 20 days (interquartile range: 14-27 days). RBC antibody formation was significantly associated with the age of RBC units (P = 0.002), with a hazard ratio of 3.5 (95% CI: 1.71-7.11) for a RBC unit that was 7 days old and 9.8 (95% CI: 2.66-35.97) for a unit that was 35 days old, 28 days after the blood transfusion. No association was observed between RBC alloimmunization and acute vaso-occlusive complications . Although increased echocardiography-derived tricuspid regurgitant jet velocity ( patients, patient5510 ) was associated with the presence of RBC alloantibodies (P = 0.02), patients, patient5510 was not significantly associated with alloimmunization when adjusted for patients, patient age and number of transfused RBC units. Our study suggests that RBC antibody formation is significantly associated with older age of RBCs at the time of transfusion. Prospective studies in patients, patient with SCD, sickle cell disease are required to confirm this finding. Am. J. Hematol., 2015. 2015 Wiley Periodicals, Inc.
| null |
1133_biomrc
|
Title: [Nuclear factor-kappa B activity at the early stage of @entity2806 and reperfusion in XXXX ].
OBJECTIVE: To observe the activity of nuclear factor-kappa B( NF-kappa B ) during reperfusion after temporary brain ischemia and to evaluate its effect. METHODS: The brain ischemia -reperfusion(I/R) model of mice was established with ligating bilateral common carotid arteries and bleeding for 0.3 ml in the tail. ANS, Abnormal nervous symptoms ( ANS, Abnormal nervous symptoms ) were recorded. Immunohistochemical technique was used to detect the activity of NF-kappa B subunit P65 and the inhibitory factor-kappa B alpha( mice93 ) in cerebral cortex during different periods of ischemia and reperfusion. Their mRNA expressions were also measured by RT-PCR. RESULTS: NF-kappa B P65 activity significantly increased 30 minutes after the reperfusion, peaking at the 2nd hour, and remaining high within 24 hours (all P < 0.05). But the mRNA expression didn't change much; mice93 and its mRNA expression began to decrease at 30 minutes after the reperfusion, peaking at the 2nd hour after the reperfusion (P < 0.05) and then gradually restored. Positive correlation was found between NF-kappa B P65 activity and ANS, Abnormal nervous symptoms (P < 0.05), while negative correlation was shown among mice93 , its mRNA, and ANS, Abnormal nervous symptoms (P < 0.05, respectively). CONCLUSION: Both activated NF-kappa B and decreased mice93 exist in the neural tissues of mice at the early stage of brain ischemia -reperfusion. The activated NF-kappa B may be involved in the ischemia -reperfusion injury.
| null |
4703_biomrc
|
Title: Near-infrared spectroscopy cerebral @entity26 saturation thresholds for XXXX -ischemia in piglets.
Detection of cerebral hypoxia-ischemia remains problematic in neonates. Near-infrared spectroscopy, a noninvasive bedside technology has potential, although thresholds for cerebral hypoxia-ischemia have not been defined. This study determined hypoxic, hypoxia -ischemic thresholds for cerebral oxygen saturation ( SCO2 ) in terms of EEG, brain ATP , and lactate concentrations, and compared these values with CBF and sagittal sinus oxygen saturation (SVO2). Sixty anesthetized piglets were equipped with near-infrared spectroscopy, EEG, laser-Doppler flowmetry, and a sagittal sinus catheter. After baseline, SCO2 levels of less than 20%, 20% to 29%, 30% to 39%, 40% to 49%, 50% to 59%, 60% to 79%, or 80% or greater were recorded for 30 minutes of normoxic normocapnia, hypercapnic hyperoxia , or bilateral carotid occlusion with or without arterial hypoxic, hypoxia . Brain ATP and lactate concentrations were measured biochemically. Logistic and linear regression determined the SCO2 , CBF, and SVO2 thresholds for abnormal EEG, ATP , and lactate findings. Baseline SCO2 was 68 + 5%. The SCO2 thresholds for increased lactate , minor and major EEG change, and decreased ATP were 44 +/- 1%, 42 +/- 5%, 37 +/- 1%, and 33 +/- 1%. The SCO2 correlated linearly with SVO2 (r = 0.98) and CBF (r = 0.89), with corresponding SVO2 thresholds of 23%, 20%, 13%, and 8%, and CBF thresholds (% baseline) of 56%, 52%, 42%, and 36%. Thus, cerebral hypoxia-ischemia near-infrared spectroscopy thresholds for functional impairment are SCO2 33% to 44%, a range that is well below baseline SCO2 of 68%, suggesting a buffer between normal and dysfunction that also exists for CBF and SVO2.
| null |
1137_biomrc
|
Title: [Coagglutination test to localize a XXXX ].
A method has been developed for discovering of antibody covered bacteria in the urine by means of a coagglutination test with a protein A containing strain--St. aureus Cowan's I. The test is based on the ability of staphylococcal protein A to bind Fc-fragment of IgG. As a specificity control St. aureus Wood 46 was used. 38 patients with urinary infection, urinary infections were examined. As pyelonephritic criteria the following were considered: febrile episodes, patients58 , polyuria , pollakiuria, leukocyturia, proteinuria , raised arterial pressure, anemia , patients77 or patients77 , x-ray, ultrasound and isotopic-nephrographic changes. In the presence of antibody covered bacteria the test is positive--there is coagglutination only with st. aureus Cowan's I. If the bacteria are not antibody coated no coagglutination takes place. If there is coagglutination with both strains the reaction is considered non-specific. II samples gave non-specific reaction. In 75% of the pyelonephritic patients the test was positive. In 70% of the patients with urinary infection, urinary infections of the lower urinary tract, i.e. with bacteria without immunoglobulins, the test was negative. In 74.1% of the cases there is a correlation between the coagglutination test and the localization of the urinary infection, urinary infections by means of other clinical and paraclinical methods. It is suggested that the coagglutination test should be included in the examination of patients with urinary infection, urinary infections , the positive test indicates renal localization of the infection .
| null |
3187_biomrc
|
Title: Radiotherapy for isolated increases in serum XXXX levels after radical prostatectomy.
OBJECTIVE: To assess the outcome of radiotherapy in patients, patient with increased serum patients, patient486 ( patients, patient486 ) levels 6 months or more after radical prostatectomy. DESIGN: In 27 Mayo Clinic patients, patient , we examined the results of radiotherapy relative to various potentially prognostic factors during a median follow-up of 25 months. MATERIAL AND METHODS: All 27 patients, patient had no nodal involvement at the time of prostatectomy and no clinical evidence of disease, as determined by history, physical examination, a radionuclide bone scan, computed tomography of the abdomen and pelvis, chest roentgenography, complete blood cell counts, and serum chemistry profiles. With use of 10-MV photons and a four-field approach, these patients, patient received irradiation to the prostatic bed (60 to 67 Gy in 1.8- to 2.0-Gy fractions). RESULTS: Levels of patients, patient486 initially decreased in 24 of the 27 patients, patient (89%). In 16 of the 27 patients, patient (59%), the patients, patient486 level decreased to 0.3 ng/mL or less without hormonal intervention. "Freedom from failure" (defined as the actuarial chance of maintaining a patients, patient486 level of 0.3 ng/mL or less) was 58% at 2 years and 48% at 3 years. The response to salvage radiotherapy was more favorable in patients, patient with no tumor, cancer in the postoperative tumor spread into the seminal vesicles and those with serum patients, patient486 levels of less than 1.1 ng/mL at the beginning of radiotherapy than in those with seminal vesicle involvement or higher patients, patient486 levels. In addition, patients, patient who received radiation doses of 64 Gy or more had more favorable responses than did those who received lesser doses. Radiotherapy resulted in no severe patients, patient37 . No patients, patient had clinical evidence of disease at the time of this report. CONCLUSION: Isolated increases in serum patients, patient486 after prostatectomy indicate the presence of residual or recurrent disease, and radiotherapy effectively decreases the patients, patient486 in approximately half the cases. This result is achieved by eradicating residual or recurrent tumor, cancer in the postoperative tumor bed.
| null |
1140_biomrc
|
Title: What factors influence provider knowledge of a XXXX guideline in a national health care system?
Provider knowledge is a potential barrier to adherence to clinical guidelines. The purpose of this study is to assess the impact of organizational, provider, and guideline factors on provider knowledge of a congestive heart failure, CHF ( congestive heart failure, CHF ) clinical practice guideline (CPG) in the Veterans Health Administration, VHA ( Veterans Health Administration, VHA ) health care system. We developed a survey to investigate institution-level factors influencing the effectiveness of guideline implementation, including characteristics of the guideline, providers, hospital culture and structure, and regional network. Survey participants, patient were quality managers, primary care administrators, and other individuals involved in primary care CPG implementation at 143 Veterans Health Administration, VHA hospitals with ambulatory care clinics. Potential explanatory variables were grouped into 11 factors. Multivariate regression models assessed the association between these factors and reported levels of provider knowledge regarding the congestive heart failure, CHF guideline at the hospital level. Two hundred forty surveys from 126 of 143 (88%) Veterans Health Administration, VHA hospitals were returned. Provider knowledge of the congestive heart failure, CHF guideline was estimated as "great" or "very great" by 58% of respondents. Three predictor factors (dissemination approaches, use of technology in guideline implementation, and hospital culture) were independently associated (P < or = .05) with provider knowledge. Specific variables within these categories that were related to greater knowledge included physician belief that guidelines were applicable to their practice, distribution of guideline summaries, use of guideline storyboards in clinic areas, the use of technology (eg, electronic participants, patient records) in CPG implementation, and establishment of implementation checkpoints and deadlines. Provider knowledge of guidelines is affected by factors at various organizational levels: dissemination approaches, use of technology, and hospital culture. Guideline implementation efforts that target multiple organizational levels may increase provider knowledge.
| null |
3190_biomrc
|
Title: Biliary complications after liver transplantation from donation after XXXX donors: an analysis of risk factors and long-term outcomes from a single center.
OBJECTIVE: This study evaluates the long-term outcomes, biliary complication rates, and risk factors for biliary complications after liver transplantation from "donation after cardiac death " (DCD) donors. BACKGROUND: Recent enthusiasm toward increased use of DCD donors' livers is mitigated by high biliary complication rates. Predictive risk factors for the development of biliary complications after DCD liver transplantation remain incompletely defined. METHODS: We performed a retrospective review of 1157 "donation after patient, Patient620 " (DBD) and 87 DCD liver transplants performed between January 1, 1993, and December 31, 2008. patient, Patient and graft survivals and complication rates within the first year of transplantation were compared between DBD and DCD groups. Cox proportional hazards models were used to assess the influence of potential risk factors. RESULTS: patient, Patient survival was significantly lower in the DCD group compared with the DBD group at 1, 5, 10, and 15 years (DCD: 84%, 68%, 54%, and 54% vs DBD: 91%, 81%, 67%, and 58%; P < 0.01). Graft survival was also significantly lower in the DCD group compared with the DBD group at 1, 5, 10, and 15 years (DCD: 69%, 56%, 43%, 43% vs DBD: 86%, 76%, 60%, 51%; P < 0.001). Rates of overall biliary complications (OBC) (DCD: 47% vs DBD: 26%; P < 0.01) and CIT, IC, ischemic cholangiopathy, cold ischemic time ( CIT, IC, ischemic cholangiopathy, cold ischemic time ) (DCD: 34% vs DBD: 1%; P < 0.01) were significantly higher in the DCD group. Donor age [hazard ratio (HR): 1.04; P < 0.01] and donor age greater than 40 years (HR: 3.13; P < 0.01) were significant risk factors for the development of OBC. Multivariate analysis revealed that CIT, IC, ischemic cholangiopathy, cold ischemic time ( CIT, IC, ischemic cholangiopathy, cold ischemic time ) greater than 8 hours (HR: 2.46; P = 0.05) and donor age greater than 40 years (HR: 2.90; P < 0.01) significantly increased the risk of CIT, IC, ischemic cholangiopathy, cold ischemic time . CONCLUSIONS: Long-term patient, Patient and graft survival after DCD liver transplantation remain significantly lower but acceptable when compared with DBD liver transplantations. Donor age and CIT, IC, ischemic cholangiopathy, cold ischemic time greater than 8 hours are the strongest predictors for the development of CIT, IC, ischemic cholangiopathy, cold ischemic time . Careful selection of younger DCD donors and minimization of CIT, IC, ischemic cholangiopathy, cold ischemic time may limit the incidence of severe biliary complications and improve the successful utilization of DCD donors' livers.
| null |
1143_biomrc
|
Title: Adult height in @entity1 with central precocious puberty treated with @entity4396 agonist with or without XXXX .
PURPOSE: There is controversy surrounding the growth outcomes of treatment with gonadotropin-releasing hormone agonist ( GnRHa ) in central precocious puberty (CPP). We analyzed height preservation after treatment with GnRHa with and without GH, growth hormone ( GH, growth hormone ) in Children, girls with CPP. METHODS: We reviewed the medical records of 82 Children, girls with idiopathic CPP who had been treated with GnRHa at Severance Children, girls 's Hospital from 2004 to 2014. We assessed the changes in height standard deviation score ( SDS ) for bone age (BA), and compared adult height, AH ( adult height, AH ) with midparental height ( MPH ) and predicted adult height, AH ( PAH ) during treatment in groups received GnRHa alone (n=59) or GnRHa plus GH, growth hormone (n=23). RESULTS: In the GnRHa alone group, the height SDS for BA was increased during treatment. adult height, AH (160.4 4.23 cm) was significantly higher than the initial PAH (156.6 3.96 cm) (P<0.001), and it was similar to the MPH (159.9 3.52 cm). In the GnRHa plus GH, growth hormone group, the height SDS for BA was also increased during treatment. adult height, AH (159.3 5.33 cm) was also higher than the initial PAH (154.6 2.55 cm) (P<0.001), which was similar to the MPH (158.1 3.31 cm). Height gain was slightly higher than that in the GnRHa alone group, however it statistically showed no significant correlation with GH, growth hormone treatment. CONCLUSION: In CPP Children, girls treated with GnRHa , the height SDS for BA was increased, and the adult height, AH was higher than the initial PAH . Combined GH, growth hormone treatment showed a limited increase in height gain.
| null |
1145_biomrc
|
Title: @entity1420 promotes cell migration, invasion and @entity12386 activation in @entity1 XXXX cells.
UNASSIGNED: Astrocytomas are the most common and aggressive humans, human313 in humans, human . Invasiveness of these malignancy, tumors has been attributed in part to deregulation of cell motility-dependent cytoskeletal dynamics that involves actin-binding proteins such as humans, human2386 . humans, human420 (P4) has been found to induce migration and invasion of cells derived from breast cancer and endothelium. However, the role of P4 in migration and invasion of astrocytomas, astrocytoma cells as well as its effects on astrocytomas, astrocytoma cytoskeleton remodeling is not known. In this work we evaluated these aspects in D54 and U251 cells derived from humans, human astrocytomas, astrocytoma from the highest degree of malignancy, tumors (grade IV, glioblastoma ). Our results showed that in scratch-wound assays P4 increased the number of D54 and U251 cells migrating from 3 to 48h. Both RU486 , a P4 receptor (PR) antagonist, and an oligonucleotide antisense against PR significantly blocked P4 effects. Transwell assays showed that P4 significantly increased the number of invasive cells at 24h. As in the case of migration, this effect was blocked by RU486 . Finally, by Western blotting, an increase in the humans, human2386 /p- humans, human2386 ratio at 15 and 30min and a decrease at 30 and 60min in U251 and D54 cells, respectively, was observed after P4, P4+ RU486 and RU486 treatments. These data suggest that P4 increases humans, human astrocytomas, astrocytoma cells migration and invasion through its intracellular receptor, and that humans, human2386 activation by P4 is independent of PR action.
| null |
1146_biomrc
|
Title: Mortality and morbidity after cytoreductive nephrectomy for metastatic XXXX : a population-based study.
PURPOSE: To test whether the rates of in-hospital mortality, complications, and transfusions are higher in patients treated with cytoreductive nephrectomy (CNT) for metastatic patients358 (mRCC) relative to patients treated with nephrectomy (NT) for non-mRCC. METHODS: We assessed 17,688 patients treated with a NT between years 1999 and 2008, within the Florida Inpatient Database. Chi-square and Student t-tests were used to compare the statistical significance of differences in proportions and means, respectively. Univariable and multivariable logistic regression analyses tested the relationship between surgery type (CNT vs. NT) and three end points: in-hospital mortality, complications, and transfusions. RESULTS: Overall, 6.0% of patients underwent CNT. The rates of in-hospital mortality, complications, and transfusions were 2.4, 26.5, and 24.3% in CNT patients versus 0.9, 18.9, and 11.1% in NT patients . At multivariable analyses, CNT patients demonstrated a 2.0-, 1.3-, and 2.4-fold higher risk of in-hospital mortality, complications, and transfusions (all P < 0.001). Similarly, more advanced age, comorbidity, and the cumulative number of secondary surgical procedures were independent predictors of a higher risk of in-hospital mortality, complications, and transfusions (all P < 0.001). CONCLUSIONS: The rate of in-hospital mortality, complications, and transfusions is higher in patients treated with CNT relative to NT. Older age, higher comorbidity, and the necessity of secondary surgical procedures further increases the risk of all aforementioned end points. Physicians should consider these observations during the planning of a CNT, and patients should be informed accordingly.
| null |
3198_biomrc
|
Title: Cardiac homeostasis is independent of XXXX venous compliance in subjects with @entity451 .
The purpose of this study was to examine cardiac hemodynamics during acute head-up tilt, HDT, head-down tilt, HUT ( head-up tilt, HDT, head-down tilt, HUT ) and calf, Calf venous function during acute head-up tilt, HDT, head-down tilt, HUT ( head-up tilt, HDT, head-down tilt, HUT ) in subjects with paraplegia compared with sedentary nondisabled controls. Nineteen paraplegic males (below T6) and nine age-, height-, and weight-matched control subjects participated. Heart rate, stroke volume, and cardiac output were assessed using the noninvasive acetylene uptake method. Venous vascular function of the calf, Calf was assessed using venous occlusion plethysmography. After supine measurements were collected, the table was moved to 10 degrees head-up tilt, HDT, head-down tilt, HUT followed by the three levels of head-up tilt, HDT, head-down tilt, HUT (10, 35, and 75 degrees ) in random order. Cardiac hemodynamics were similar between the groups at all positions. calf, Calf circumference was significantly reduced in the paraplegic group compared with the control group (P < 0.001). Venous capacitance and compliance were significantly reduced in the paraplegic compared with control group at supine and head-up tilt, HDT, head-down tilt, HUT . Neither venous capacitance (P = 0.37) nor compliance (P = 0.19) increased from supine with 10 degrees head-up tilt, HDT, head-down tilt, HUT in the paraplegic group. A significant linear relationship was established between supine venous compliance and supine cardiac output in the control group (r = 0.80, P < 0.02) but not in the paraplegic group. The findings of reduced calf, Calf circumference and similar venous capacitance at supine rest and 10 degrees head-up tilt, HDT, head-down tilt, HUT in the paraplegic group imply that structural changes may have limited venous dispensability in individuals with chronic paraplegia . Furthermore, the lack of a relationship between supine venous compliance and supine cardiac output suggests that cardiac homeostasis does not rely on venous compliance in subjects with paraplegia .
| null |
3200_biomrc
|
Title: The XXXX symptom evaluation survey as a screening tool for @entity27 .
OBJECTIVE: To determine if clinical data and Nasal Obstruction Symptom Evaluation (NOSE) scores can be used to identify Patients, patients, PATIENTS at risk for obstructive sleep apnea, OSA ( obstructive sleep apnea, OSA ). DESIGN: Intake surveys using the NOSE, Epworth Sleepiness Scale, ESS ( Epworth Sleepiness Scale, ESS ), and Snore Outcomes Scale (SOS) were administered to new Patients, patients, PATIENTS visiting a facial plastic surgery practice and a rhinology practice. SETTING: An academic facial plastic surgery practice and an academic rhinology practice. Patients, patients, PATIENTS : New Patients, patients, PATIENTS to both practices. MAIN OUTCOME MEASURES: NOSE score and presence of septal deviation. RESULTS: The odds ratio (OR) for an Epworth Sleepiness Scale, ESS score higher than 10 was 2.98 (95% confidence interval [CI], 1.17-7.57) when snoring was present; 5.5 (95% CI, 1.35-22.58) when the NOSE score was 10 or higher; and 3.3 (95% CI, 0.98-11.0) when a deviated septum was found on clinical examination. The probability of an elevated Epworth Sleepiness Scale, ESS score was 88% when all 3 factors were present and 56% when the NOSE score was not elevated. Receiver operating characteristic analysis with predictors "snore" and NOSE score of 10 or higher had an area under the curve of 0.72. With a probability cutoff of 0.5, the sensitivity was 30%, and the specificity 90%. CONCLUSIONS: Sinonasal surgery is among the most common outpatient procedures performed in the United States each year. Many Patients, patients, PATIENTS undergoing sinonasal surgery have undiagnosed obstructive sleep apnea, OSA or nasal obstruction , a known risk factor for obstructive sleep apnea, OSA . Patients, patients, PATIENTS with obstructive sleep apnea, OSA have unique perioperative needs. In Patients, patients, PATIENTS with nasal obstruction , a deviated septum , and/or snoring, there is an association between the NOSE score and the Epworth Sleepiness Scale, ESS score. The NOSE survey may serve as a simple screening instrument instead of the Epworth Sleepiness Scale, ESS for Patients, patients, PATIENTS at risk for undiagnosed obstructive sleep apnea, OSA and special perioperative needs.
| null |
1154_biomrc
|
Title: Plantar Pressure Distribution Pattern during Mid-Stance Phase of the Gait in Patients with Chronic Non-Specific Low Back XXXX .
OBJECTIVE: To examine the characteristics of the plantar pressure distribution patterns during mid-stance phase of the gait cycle in subjects with chronic non-specific low back pain and asymptomatic subjects. MATERIAL AND METHOD: Twenty-three males and 17 females with chronic non-specific low back pain and age- and gender-matched asymptomatic subjects walked barefoot along a gait mat at comfortable speedfor three trials. The left and right plantar pressure distributions were recorded during mid-stance phase and divided into 12 areas. Descriptive statistics including mean and standard deviation of demographic data and plantar pressure were calculated, and plantar pressure distribution patterns were described. RESULTS: Mean and standard deviation of pain, numeric pain rating scale of chronic non-specific low back pain group were 4.04 1.58. The average mean peak pressure of both chronic non-specific low back pain and asymptomatic subjects located at the fifth area (lateral aspect offorefoot) in both feet. However the modes of the peak pressure of subjects with chronic non-specific low back pain were in the different areas in the left and right feet. The distribution patterns of the average mean peak pressure were not the same in chronic non-specific low back pain and asymptomatic subjects. This altered foot contact in the subjects with chronic non-specific low back pain may be used to avoid pain, numeric pain or to compensate for limited mobility of the lower limbs at pre-swing phase. CONCLUSION: At mid-stance phase of walking, the pressures on the plantar surface were unequally distributed in subjects with chronic non-specific low back pain .
| null |
1160_biomrc
|
Title: Oral tori in chronic hemodialysis XXXX .
BACKGROUND: This study investigated the epidemiology of TP, torus palatinus, torus mandibularis, TM ( TP, torus palatinus, torus mandibularis, TM ) and TP, torus palatinus, torus mandibularis, TM ( TP, torus palatinus, torus mandibularis, TM ) in hemodialysis patients and analyzed the influences of hyperparathyroidism on the formation of oral tori. METHOD: During 2013, 119 hemodialysis patients were recruited for dental examinations for this study. RESULTS: The prevalence of oral tori in our sample group was high at 33.6% (40 of 119). The most common location of tori was TP, torus palatinus, torus mandibularis, TM (70.0%), followed by TP, torus palatinus, torus mandibularis, TM (20.0%), and then both TP, torus palatinus, torus mandibularis, TM and TP, torus palatinus, torus mandibularis, TM (10.0%). Of the 40 tori cases, most (67.5%) were <2 cm in size; moreover, the majority (52.5%) were flat in shape. In symmetry, most (70.0%) occurred in the midline, followed by bilateral sides (20.0%). Notably, the levels of intact parathyroid hormone did not differ in patients with or without tori (P = 0.611). Furthermore, patients with tori did not differ from patients without tori in inflammatory variables such as log high-sensitivity patients851 (P = 1.000) or nutritional variables such as albumin (P = 0.247). Finally, there were no differences between patients with and without tori in adequacy of dialysis (P = 0.577). CONCLUSIONS: Neither hyperparathyroidism nor inflammation malnutrition syndrome was found to contribute to the formation of oral tori in chronic hemodialysis patients . Further studies are warranted.
| null |
1164_biomrc
|
Title: [Echocardiographic assessment of circulation system in XXXX during and 3-5 years after all therapy in childhood].
Circulatory disturbances may occur during and after the treatment of ALL, acute lymphoblastic leukemia ( ALL, acute lymphoblastic leukemia ). The reasons are: leukemic infiltrations of the heart, anaemia , renal disturbances, infections , children, patients, persons370 drugs, especially renal disturbances, infections253 (Atc). The aim of the study was echocardiographic assessment of circulatory system in children, patients, persons during and 3-5 years after ALL, acute lymphoblastic leukemia therapy in childhood. The study group (group B) consisted of 20 children, patients, persons , aged 1-16 years, who underwent Atc treatment with cumulative doses 155.8-330 mg/m2 and cardioprotective agent-- children, patients, persons0976 . In this group echocardiography was performed before the treatment as well as after 1, 6, 12 months and 3 years. The retrospective group (R) consisted of 36 children, patients, persons aged 12-24 years, examined 3-5 years after the completion of ALL, acute lymphoblastic leukemia treatment, who had undergone the treatment with Atc in doses 148.6-416.7 mg/m2 without cardioprotection. The control group (K) consisted of 28 healthy volunteers, aged 9-25 years. In all subjects echocardiography was performed, standard measurements taken, systolic and diastolic indices of left ventricle (LV) function calculated. In children, patients, persons during and 3-5 years after the treatment neither LV dilatation nor abnormal wall-thickness was found. The systolic indices remained normal. In the group B echocardiographic indices did not change significantly during 3 years of treatment and did not correlate with growing cumulative Atc doses. In this group isovolumetric relaxation time (IVRT) was significantly longer, what emphasized the need of further clinical and echocardiographic follow-up.
| null |
1169_biomrc
|
Title: Evaluation of Genome Wide Association Study Associated Type 2 XXXX Susceptibility Loci in Sub Saharan Africans.
UNASSIGNED: Genome wide association studies (GWAS) for type 2 diabetes, T2D ( type 2 diabetes, T2D ) undertaken in European and Asian ancestry populations have yielded dozens of robustly associated loci. However, the genomics of type 2 diabetes, T2D remains largely understudied in sub-Saharan Africa (SSA), where rates of type 2 diabetes, T2D are increasing dramatically and where the environmental background is quite different than in these previous studies. Here, we evaluate 106 reported type 2 diabetes, T2D GWAS loci in continental Africans. We tested each of these SNPs, and SNPs in linkage disequilibrium (LD) with these index SNPs, for an association with type 2 diabetes, T2D in order to assess transferability and to fine map the loci leveraging the generally reduced LD of African genomes. The study included 1775 unrelated Africans (1035 type 2 diabetes, T2D cases, 740 controls; mean age 54 years; 59% female) enrolled in Nigeria, Ghana, and Kenya as part of the Africa America Diabetes Mellitus (AADM) study. All samples were genotyped on the Affymetrix Axiom PanAFR SNP array. Forty-one of the tested loci showed transferability to this African sample (p < 0.05, same direction of effect), 11 at the exact reported SNP and 30 others at SNPs in LD with the reported SNP (after adjustment for the number of tested SNPs). TCF7L2 SNP rs7903146 was the most significant locus in this study (p = 1.61 * 10(-8)). Most of the loci that showed transferability were successfully fine-mapped, i.e., localized to smaller haplotypes than in the original reports. The findings indicate that the genetic architecture of type 2 diabetes, T2D in SSA is characterized by several risk loci shared with non-African ancestral populations and that data from African populations may facilitate fine mapping of risk loci. The study provides an important resource for meta-analysis of African ancestry populations and transferability of novel loci.
| null |
3217_biomrc
|
Title: Identifying potential indicators to measure the outcome of translational XXXX research: a mixed methods approach.
BACKGROUND: In a context where there is an increasing demand to evaluate the outcome of bio-medical research, our work aims to develop a set of indicators to measure the impact of translational cancer research. The objective of our study was to explore the scope and issues of translational research relevant to evaluation, explore the views of researchers on the evaluation of oncological translational research, and select indicators measuring the outcomes and outputs of translational research in oncology by consensus. METHODS: Semi-structured interviews amongst 23 researchers involved in translational cancer research were conducted and analysed using thematic analysis. A two-round modified Delphi survey of 35 Participants, patient, participants with similar characteristics was then performed followed by a physical meeting. Participants, patient, participants rated the feasibility and validity of 60 indicators. The physical meeting was held to discuss the methodology of the new indicators. RESULTS: The main themes emerging from the interviews included a common definition for translational research but disagreements about the exact scope and limits of this research, the importance of multidisciplinarity and collaboration for the success of translational research, the disadvantages that translational research faces in current evaluation systems, the relative lack of pertinence of existing indicators, and propositions to measure translational cancer research in terms of clinical applications and Participants, patient, participants outcomes. A total of 35 Participants, patient, participants took part in the first round survey and 12 in the second round. The two-round survey helped us select a set of 18 indicators, including four that seemed to be particularly adapted to measure translational cancer research impact on health service research (number of biomarkers identified, generation of clinical guidelines, citation of research in clinical guidelines, and citation of research in public health guidelines). The feedback from Participants, patient, participants helped refine the methodology and definition of indicators not commonly used. CONCLUSION: Indicators need to be accepted by stakeholders under evaluation. This study helped the selection and refinement of indicators considered as the most relevant by researchers in translational cancer research. The feasibility and validity of those indicators will be tested in a scientometric study.
| null |
3219_biomrc
|
Title: Conservative XXXX treatment: analysis of cosmetic results and the role of concomitant adjuvant chemotherapy.
Fifty-eight patients, patient conservatively treated for T1 breast cancers are analyzed for cosmetic outcome; 17 had concomitant adjuvant combination chemotherapy ( cyclophosphamide , adriamycin , 5 patients, patient487 ). The results are evaluated by clinical criteria and a quantitative measurement by use of light field projection at 33 months median follow-up. Surgery consisted of lumpectomy and axillary dissection; radiotherapy was given to the breast only except for additional internal mammary irradiation in central and medial lesions. (50 Gy whole breast, 64 Gy electron/photon boost). Questionnaires are used for inquiry on patients, patient experience: 88% of the patients, patient experienced a good to excellent cosmetic outcome. According to the panel only 64% show a good to excellent cosmesis. Panel-scores on asymmetry are compared with quantitative measurements. More esophagitis and probably a higher degree of fibrosis in the boost area is found in the chemotherapy group. No differences in cosmetic outcome, complication rates, and patients, patient experiences are seen. Results are compared with published data.
| null |
1170_biomrc
|
Title: How long is it possible to continue the chemotherapy for recurrent XXXX ?
UNASSIGNED: 5126 Background: Although the majority of women, patients with advanced ovarian cancer will recur, there is no standard regimen for these women, patients . We evaluated women, patients37 and number of chemotherapy courses for recurrent ovarian cancer . METHODS: Since 1991, sixty-five women, patients with recurrent ovarian cancer have received chemotherapy. Of 65 women, patients , 16 women, patients had more than 10 courses of same regimen of women, patients311 or Carboplatin, carboplatin as the second or the third or the forth line chemotherapy. Retrospective chart view was performed and clinical data obtained. women, patients37 and disease status were assessed in all women, patients . RESULTS: Median age of the women, patients is 57 y.o.( range 35 to 69). Eleven women, patients had platinum based chemotherapy without women, patients311 and 5 women, patients received platinum plus women, patients311 chemothrapy as the first line therapy. Median interval from the end of the first line chemotherapy to recurrence was 12 months (range 1-108 months). Three women, patients received single agent Carboplatin, carboplatin for 12, 23 and 63+ courses. Fourteen women, patients received 10 to 52+ courses of women, patients311 (median 17). Nine women, patients received women, patients311 and Carboplatin, carboplatin altanatively. The median follow-up duration was 41 months (range: 9-126). Eight women, patients are alive with disease and continuing chemotherapy. CONCLUSIONS: Today, we do not have standard regimen for recurrent ovarian cancer and many new drugs are under clinical study. At time of last follow up, upto 63 courses of Carboplatin, carboplatin and upto 52 courses of women, patients311 therapy were possible. Carboplatin, carboplatin and women, patients311 is widely used as the first line chemotherapy and the women, patients37 are well known. Then these drugs are familiar and easy to use for clinicians. For some group of recurrent women, patients , those two drugs are also effective and tolerable to use for multiple courses as single agent for a long duration and contribute to prolongate these women, patients life. No significant financial relationships to disclose.
| null |
3221_biomrc
|
Title: High expression of @entity2940 ( XXXX ) in a @entity1 with cutaneous @entity404 -positive @entity706 .
Cutaneous lymphoma, cutaneous lymphoma is a disease characterized with massive skin infiltration of lymphoid malignant cells. They commonly express some T-cell markers, such as CD2 , CD3, CD4 , and CD7 , and thus termed as CTCL, cutaneous T cell lymphoma ( CTCL, cutaneous T cell lymphoma ). Here, we present a case with N-CAM, CD56 / N-CAM, CD56 -positive Cutaneous lymphoma, cutaneous lymphoma , which appears lymphocytic morphology and expresses CD4 , but does not express CD2 , CD3, CD8 , CD14 , CD16 , CD57 , and CD20 . The most malignant cells contained no distinctive azurophilic granules in the cytoplasm. Southern blot analysis revealed that T cell receptor-beta, gamma, and immunoglobulin heavy chain genes in the cells were in germ-line configurations. Electron microscopic examination showed characteristics of lymphoid cells with higher nucleocytoplasmic ratio and lacked structures typical of other cell types (i.e., epithelial cells, neuroendocrine cells, and mesenchymal cells). Thus, the cells are likely to be immature lymphoid cells. Histological analysis revealed the cells infiltrate mainly into the dermis with angiocentric growth pattern. The clinical course was patient46 , with rapid involvement of bone marrow and central nervous system. These striking features of the patient may represent a novel fraction ( CD2 -, CD4 +, and N-CAM, CD56 +) of Cutaneous lymphoma, cutaneous lymphoma .
| null |
3226_biomrc
|
Title: A signature of aberrant immune responsiveness identifies @entity296 in XXXX .
OBJECTIVE: Heart failure is an important cause of death in patients with rheumatoid arthritis, RA ( rheumatoid arthritis, RA ). Evidence suggests that immune mechanisms contribute to myocardial injury, myocardial dysfunction and fibrosis , leading to patients002 ( patients002 ). The purpose of this study was to identify a signature of patients002 in patients with rheumatoid arthritis, RA by analyzing the responsiveness of the innate and adaptive immune systems to stimulation ex vivo. METHODS: rheumatoid arthritis, RA patients (n=212) enrolled prospectively in a population-based cohort underwent echocardiography, and LV function was classified as normal, mild patients002 , or moderate-to-severe patients002 . The release of 17 cytokines by blood mononuclear cells in response to stimulation with a panel of 7 stimuli or in media alone was analyzed using multiplex immunoassays. Logistic regression models were used to test for associations between a multicytokine immune response score and patients002 , after adjusting for clinical covariates. RESULTS: An 11-cytokine profile effectively differentiated patients with moderate-to-severe patients002 from those with normal LV function. An immune response score (range 0-100) was strongly associated with moderate-to-severe patients002 (odds ratio per 10 units 1.5 [95% confidence interval 1.2-2.1]) after adjusting for serum interleukin-6 levels, brain natriuretic peptide values, and glucocorticoid use, as well as other rheumatoid arthritis, RA characteristics and patients002 risk factors. CONCLUSION: The major finding of this study was that aberrant systemic immune responsiveness is associated with advanced myocardial injury, myocardial dysfunction in patients with rheumatoid arthritis, RA . The unique information added by the immune response score concerning the likelihood of patients002 warrants future longitudinal studies of its value in predicting future deterioration in myocardial function.
| null |
3230_biomrc
|
Title: @entity1860 in The Netherlands: a Population-Based Study on Incidence, Treatment and Survival in 3,585 XXXX from 1989-2012.
OBJECTIVE: To assess the impact and results of treatment of patients, Patient, person860 in the general population, we conducted a population-based, nation-wide study on 3,585 patients, Patient, person860 patients, Patient, person diagnosed between 1989 and 2012 in the Netherlands. METHODS: patients, Patient, person demographics were obtained from the Netherlands Cancer Registry. Information on age, gender, year of diagnosis, first treatment and date of death were recorded. patients, Patient, person349 ( patients, Patient, person349 ) was adjusted for death rates in the normal population. RESULTS: Incidence in males decreased slightly from 1.2 per 100.000 patients, Patient, person years (PY) in 1989-2000 to 0.9 in 2001-2012. For females, incidence remained stable with 0.7 per 100.000 PY in both periods. Incidence was age dependent and highest in males in the last decades of life. Treatment before 2000 mainly consisted of chemotherapy, while after 2007 TKI use was 88%. Five-year relative survival was only 36% before the introduction of TKIs but significantly increased to79% after the introduction of TKI. CONCLUSIONS: This study gives insight in patients, Patient, person860 incidence, treatment and survival in routine care in the Netherlands. Although patients, Patient, person349 improved since the introduction of TKIs, there is still room for further improvement. This article is protected by copyright. All rights reserved.
| null |
1182_biomrc
|
Title: Initial therapy, persistence and regimen change in a cohort of newly treated XXXX 2 @entity6 @entity1 .
AIMS: To describe the utilisation of antidiabetic agents , in terms of persistence and regimen change in the management of a cohort of newly treated patients64 2 diabetes patients and to investigate associated socio-demographic and treatment factors. METHODS: A population-based retrospective cohort study was conducted using the national pharmacy claims database in Ireland. Subjects were analysed for persistence and regimen change. Cox proportional-hazards regression examined associations of socio-demographic and treatment factors on treatment patterns. Hazard ratios (HR) and 95% CIs are presented. RESULTS: 20947 subjects were identified in the study over a 2 year period. Most were initiated on metformin (76%) or sulphonylureas (22%) and 77% were persistent with therapy 12 months after initiation. The likelihood of non-persistence was significantly lower in the youngest (40-49) age groups (ref 60-69) (HR 1.62 [CI 1.42-1.84]) and those on sulphonylureas (HR 1.49 [1.36-1.64]). The likelihood of receiving a regimen change was significantly lower in the older (80+) age groups (HR 0.63 [0.56-0.71]), females (HR 0.91 [0.86-0.95], and those with pre-existing CVD (1 vs 0 CVD medicines) (HR 0.82 [0.74-0.90]), and higher in those on sulphonylureas (HR 1.83 [1.73-1.94]) CONCLUSIONS: Type of treatment, pre-existing CVD and demographic factors are shown to be associated with the observed treatment patterns. Guideline recommended agents were widely used on treatment initiation though a substantial minority were not initiated on the recommended first line agent. Use of guideline recommended agents was not as evident during treatment progression. Further optimisation of initial and subsequent antidiabetic agent prescribing may be possible.
| null |
1184_biomrc
|
Title: Endogenous kappa-opioid systems in opiate withdrawal: role in aversion and accompanying changes in mesolimbic XXXX release.
The kappa-opioid receptor antagonist nor-BNI, nor-binaltorphimine, Nor-BNI ( nor-BNI, nor-binaltorphimine, Nor-BNI ) was recently shown to potentiate certain overt withdrawal signs in morphine, Morphine -dependent Rats, rats . The present study sought to further assess this phenomenon by examining the influence of nor-BNI, nor-binaltorphimine, Nor-BNI treatment upon the conditioned place aversion associated with the naloxone -precipitated withdrawal syndrome . In addition, in vivo microdialysis studies were conducted in morphine, Morphine -dependent Rats, rats to determine whether nor-BNI, nor-binaltorphimine, Nor-BNI treatment can modify withdrawal-induced changes in basal dopamine (DA) release within the mesolimbic system. Rats, rats were pretreated with either saline or a single dose of nor-BNI, nor-binaltorphimine, Nor-BNI and then received ascending doses of morphine, Morphine for 10 days. A withdrawal syndrome was then precipitated by the administration of naloxone (1 mg/kg SC). In Rats, rats which received chronic morphine, Morphine injections, administration of naloxone produced a characteristic withdrawal syndrome and a marked aversion for an environment previously associated with naloxone -precipitated withdrawal. nor-BNI, nor-binaltorphimine, Nor-BNI treatment potentiated most overt signs of physical dependence . This treatment also resulted in a greater withdrawal-induced place aversion. morphine, Morphine -dependent Rats, rats exhibited a marked reduction in basal mesolimbic DA release. An even greater decrease in basal DA release was observed in nor-BNI, nor-binaltorphimine, Nor-BNI treated Rats, rats . These results suggest that endogenous kappa-systems are important in the modulation of mesolimbic DA release and the accompanying place aversion which occurs during opiate withdrawal.
| null |
3235_biomrc
|
Title: A biopsychosocial investigation of changes in self-concept on the XXXX Semantic Differential Scale.
UNASSIGNED: This study aimed to investigate the influence of the "good-old-days" bias, neuropsychological functioning and cued recall of life events on self-concept change. Forty seven adults with participants31 (70% male, 1-5 years post-injury) and 47 matched controls rated their past and present self-concept on the Head Injury Semantic Differential Scale (HISD) III. participants31 participants also completed a battery of neuropsychological tests. The matched control group of 47 were from a sample of 78 uninjured participants who were randomised to complete either the Social Readjustment Rating Scale-Revised (cued recall) or HISD (non-cued recall) first. Consistent with the good-old-days bias, participants with participants31 rated their pre-injury self-concept as more positive than their present self-concept and the present self-concept of controls (p < .05). More positive pre-injury self-concept ratings were related to lower estimated premorbid IQ and poorer verbal fluency and delayed memory (p < .05). For uninjured participants , cued recall, life events and event appraisals each accounted for unique variance in self-concept change (p < .01) after controlling for negative affect. The cued recall group rated their past self-concept as significantly more negative than the non-cued group (p < .01). Overall, the good-old-days bias, neuropsychological functioning and cued recall influenced reports of self-concept change by affecting retrospective ratings of past self-concept. Further research is needed to investigate the impact of contextual cues on self-concept change after participants31 .
| null |
3242_biomrc
|
Title: XXXX . A report of 19 cases and a review of the literature.
Clinical, roentgenographic and pathologic findings in patients with chronic eosinophilic pneumonia , including 19 additional cases, have been reviewed and summarized. Most patients present with subacute respiratory and constitutional symptoms and have failed to respond to therapy for presumptive pneumonia . A previous history of atopy, most often asthma , will be obtained in one-half. patients712 occurs in most cases and its absence may be the major indication for lung biopsy. Although peripheral pulmonary infiltrates, pulmonary infiltrates are more often peripheral than not, the classic "photographic negative of pulmonary edema " is seen in less than one-third of cases. Pathologic findings include an intra-alveolar and interstitial infiltrate which comprises eosinophils, histiocytes, and exudate. Bronchiolitis obliterans, bronchiolitis obliterans and eosinophilic microabscesses occur less frequently. Open-lung biopsy is preferable when atypical features prevent a confident clinical diagnosis. The exquisite responsiveness of patients2563 to corticosteroids should encourage use of a therapeutic trial when there is a strong clinical suspicion of the disorder. The rapid clinical response should not deter the clinician from giving a prolonged course of treatment. The differential diagnosis includes other diseases characterized by PIE and the more recently recognized Bronchiolitis obliterans, bronchiolitis obliterans and organizing pneumonia , a disorder which is also marked by peripheral pulmonary infiltrates, pulmonary infiltrates .
| null |
3246_biomrc
|
Title: Characterization of three novel members of the XXXX SHAGGY-related protein kinase (ASK) multigene family.
In this paper we report the characterization of three novel members of the Arabidopsis shaggy-related protein kinase (ASK) multigene family, named ASKdzeta (ASKzeta), ASKetha (ASKeta) and ASKiota (ASKiota). The proteins encoded by the ASK genes share a highly conserved catalytic protein kinase domain and show about 70% identity to SHAGGY (SGG) and glycogen synthase kinase-3 (GSK-3 ) from Drosophila and rat respectively. SGG is an ubiquitous intracellular component of the wingless signalling pathway that establishes cell fate and/or pattern formation in Drosophila . At least ten different ASK genes are expected to be present per haploid genome of A. thaliana. Different amino - and carboxy -terminal extensions distinguish different ASK family members. Five ASK gene sequences were analysed and shown to be present as single-copy genes in the Arabidopsis genome. A comparison based on the highly conserved catalytic domain sequences of all known sequences of the GSK-3 subfamily of protein kinases demonstrated a clear distinction between the plant and the animal kinases. Furthermore, we established the presence of at least three distinct groups of plant homologues of SGG/GSK-3. These different groups probably reflect biochemical and/or biological properties of these kinases. The differential expression patterns of five ASK genes were accessed by northern and in situ hybridization experiments using gene-specific probes. While ASKzeta is expressed in the whole embryo during its development, ASKeta expression is limited to the suspensor cells. No signal was detected for ASKalpha, ASKgamma and ASKiota in developing embryos.
| null |
3247_biomrc
|
Title: @entity1252 complicated with femoral XXXX treated by Chinese medicine therapy for activating blood and dredging collaterals method.
OBJECTIVE: To observe the effect and mechanism of Chinese medicine therapy for activating blood and dredging collaterals (ABDC) on treating patients252 complicated with avascular necrosis of the femoral head (SLE-ANFH). METHODS: Thirty-four patients (51 joints) with SLE-ANFH were assigned by a random number table to two groups: 22 patients (32 joints) in the treatment group and 12 patients (19 joints) in the control group. All received Western medical conventional treatment for anti- inflammation and immunosuppression, but an additional Chinese medicine decoction prescribed based on ABDC principle was administered to patients in the treatment group. The observation on the patients ' condition and therapeutic effect lasted for 3 years. RESULTS: The patients ' conditions in the two groups, as assessed by Association for Research Circulation Osseous (ARCO) staging, were similar before treatment. After treatment, comparison between groups showed significant difference (P<0.05), and the raised Harris functional scores in the treatment group were higher than that in the control group (P<0.01). The post-treatment symptom improving rate in the treated group was 72.73%, which was higher than that in the control group (50.00%, P<0.05). Moreover, the former was superior in improving hematologic and hemorrheologic parameters in terms of prolonging activated partial thromboplastin time, lowering whole blood middle/low shear viscosity, and plasma viscosity (P<0.05 or P<0.01). Two patients in the control group but none in the treatment group received hip joint replacement operation during the observation period. CONCLUSIONS: Chinese medicine ABDC therapy could effectively alleviate clinical symptoms and improve joint function of patients with SLE-ANFH. The mechanism may be related to its effects on improving high coagulation manner and trend for getting embolism .
| null |
1198_biomrc
|
Title: @entity706 : XXXX diagnosed as a double @entity5 and improved with chemotherapy, and literature review of primary @entity706 .
parasellar lymphoma, Lymphoma is one of the causative factors of hypothalamus-pituitary dysfunction, pituitary stalk , and patient, woman, patients892 ( patient, woman, patients892 ) is a subtype of primary extranodal neoplasm, cancer-adenocarcinoma . A 69-year-old patient, woman, patients visited our hospital because of general fatigue. We diagnosed her with presumable non-functional primary pituitary adenoma and subsequent dysfunction . Eight months after, the patient, woman, patients revisited our hospital because of patient, woman, patients353 . Though we conducted systemic investigations including chest and abdomen enhanced computer tomography, transbronchial lung biopsy, and bone marrow biopsy, the diagnosis was not confirmed. Inadvertently, a breast cancer was found, and the surgical specimen proved that the patient, woman, patients had double neoplasm, cancer-adenocarcinoma and patient, woman, patients892 . Rituximab, cyclophosphamide , adriamycin , patient, woman, patients891 , and prednisolone regimen was initiated, and complete remission was achieved. Notably, the sellar mass returned to normal size with improved function. We reviewed 32 patient, woman, patients with primary parasellar lymphoma, Lymphoma . In affected sites, both sellar and hypothalamus-pituitary dysfunction, pituitary stalk (6.7%), both hypothalamus and hypothalamus-pituitary dysfunction, pituitary stalk (6.7%), only sellar (63.3%), only hypothalamus-pituitary dysfunction, pituitary stalk (6.7%), only hypothalamus (13.3%), and only clivus (3.3%) were observed. In hypothalamus-pituitary dysfunction, pituitary stalk , both anterior and posterior dysfunction (20.7%), only anterior dysfunction (58.6%), only posterior dysfunction (3.4%), and no dysfunction (17.2%) were observed. It seemed that patient, woman, patients640 is related to both anterior and posterior dysfunction , while sellar lesion is related to mainly anterior dysfunction. In patient, woman, patients29 , 2nd patient, woman, patients29 (45.2%) and 6th patient, woman, patients29 (35.5%) were frequently observed. It seemed that sellar lesion is related to both 2nd and 6th patient, woman, patients29 , while patient, woman, patients640 is related to mainly 2nd patient, woman, patients29 .
| null |
1199_biomrc
|
Title: Effect of @entity15150 on the Biosynthesis of @entity4793 in XXXX ( @entity4335 .) and Arabidopsis.
UNASSIGNED: Elevating the yield and altering the composition of seed tocopherols (Toc's) are important to rapeseed breeding and production. However, little is known about the biosynthesis of Toc's in response to environmental signals. In this study, we investigated the effects of exogenous gibberellin (GA3) and paclobutrazol (PAC) on Toc biosynthesis. We also explored the interactive effects between the two plant growth regulators (PGRs) and other factors, such as PGR treatment duration, genotype, and growing location on the total Toc yield and composition in oilseed rape seed. GA3 significantly enhanced the production of Toc's and elevated the a-/y-Toc ratio in a time- and genotype-dependent manner. By contrast, PAC significantly reduced Toc yield. Genotypic differences were observed in the effects of GA3 on Toc yield and composition in the seeds. GA3 significantly increased the Toc yield and a-/y-Toc ratio in Zheyou-50, a genotype with a low proportion of very long chain fatty acids (VLCFAs). However, GA3 did not significantly influence these parameters in Jiu-Er-13Xi, a genotype with a high VLCFA proportion. The increased Toc yield induced by GA3 was mediated by the upregulation of genes ( BnPDS1 and BnVTE1) that catalyze the production of Toc precursors. Therefore, applying GA3 can improve rapeseed quality by increasing Toc yield and improving Toc composition.
| null |
3252_biomrc
|
Title: Secretion and dynamics of herpes simplex virus in tears and saliva of XXXX with @entity4401 .
OBJECTIVE: For clarification of the direct relationship between the reactivation of herpes simplex virus and the development of "Bells Palsy" , a detection of the virus genome by deoxyribonucleic acid diagnostics and a quantitative analysis of its time-course change are both needed. The authors detected the HSV genome in specimens from patients with "Bells Palsy" , quantified its number of copies, and examined time-course changes. SUBJECTS AND METHODS: The subjects were 16 patients with "Bells Palsy" . The tear fluid and saliva from the submandibular gland and the parotid gland were separately collected from the affected and unaffected sides twice or more. A total of 244 specimens were subjected to extraction of deoxyribonucleic acid , polymerase chain reaction, and microplate hybridization. RESULTS: Herpes simplex virus-1, herpes simplex virus-1 deoxyribonucleic acid was detected in 38 specimens (11.8%) from 5 patients (31%). The high detection (28.5%) was obtained within 2 weeks after onset. Detection at 3 weeks and later (2.8%) was significantly lower ( < 0.05). In three cases, deoxyribonucleic acid was also found on the unaffected side in the initial phase of the disease, but detection on that side (18.9%) was significantly lower than on the affected side (83.8%) ( < 0.01). The number of copies of the Herpes simplex virus-1, herpes simplex virus-1 genome was large on the affected side and early after the onset of the disease. CONCLUSIONS: The reactivation of Herpes simplex virus-1, herpes simplex virus-1 on the affected side is involved as a pathogenic factor of "Bells Palsy" . A reactivation of Herpes simplex virus-1, herpes simplex virus-1 may be generated even on the unaffected side in the early phase of the disease. Herpes simplex virus deoxyribonucleic acid was not detected in any of the examined specimens collected from the remaining 11 cases. The need for constant study to clarify other causative factors of "Bells Palsy" remains.
| null |
3253_biomrc
|
Title: Central representation of visceral and cutaneous hypersensitivity in the XXXX .
We have previously shown that patients744 ( patients744 ) patients have both visceral and cutaneous patients931 . The neural mechanisms of these forms of patients931 were further characterized by comparing cortical processing of both rectal distension (35, 55mmHg) and cutaneous heat nociceptive stimuli (foot immersion in 45 and 47 degrees C water bath) in patients744 patients and in a group of healthy age/sex-matched controls. Our approach relied on functional magnetic resonance imaging neuroimaging analyses in which brain activation in age/sex-matched control subjects was subtracted from that found in patients744 patients . These analyses revealed that both rectal distension and cutaneous heat stimuli evoked greater neural activity in several brain regions of patients744 patients in comparison to age/sex-matched control subjects. These include those related to early stages of somatosensory processing (e.g. thalamus, somatosensory cortex) as well as those more related to cognitive and affective processing (insular, anterior cingulate, posterior cingulate, prefrontal cortex). Thus, our results support the hypothesis that patients931 of patients744 is manifested by increased somatosensory processing at all cortical levels. This was found to be the case not only for patients931 but also for cutaneous patients931 , a likely form of secondary patients931 . Furthermore, visceral and patients931 were accompanied by increased neural activity within the same brain structures. These results support the hypothesis that visceral and cutaneous patients931 in patients744 patients is related to increased afferent processing in pathways ascending to the brain rather than to selectively increased activity at higher cortical levels (e.g. limbic and frontal cortical areas).
| null |
1207_biomrc
|
Title: @entity364 and complications involving the bronchial @entity254 following XXXX lung transplantation.
STUDY OBJECTIVE: To demonstrate an association between saprophytic fungal infections, Saprophytic fungal infections occurring at the bronchial anastomosis (BA) and the development of additional complications arising at this site. DESIGN: Retrospective review. SETTING: University lung transplant center. MATERIALS AND METHODS: Review of all single-lung and double-lung transplant (LTX) recipients who underwent transplantation between June 1993 and December 2000. All recipients were subjected to surveillance bronchoscopy with biopsy at predetermined intervals and when clinically indicated. Bronchial wash fluid and biopsy material were examined using appropriate fungal stains and culture techniques. An anastomotic infections, infection, infections, anastomotic infection was defined when fungal organisms were identified in tissue specimens. RESULTS: Fifteen saprophytic fungal infections, Saprophytic fungal infections involving the BA were identified in 61 LTX recipients (24.6%) who survived a minimum of 75 days post-transplantation. Infections were attributed to Aspergillus sp (n = 9), Candida sp (n = 2), Torulopsis sp (n = 1), and mixed flora (ie, Penicillium + Candida, two patients, patient ; and Aspergillus + Candida, one patients, patient ). fungal infections, Saprophytic fungal infections occurred by a median of postoperative day 35 (range, 13 to 159 days). Airway complications involving the BA ultimately developed in 11 of 61 recipients (18%). These complications included symptomatic bronchial stenosis (nine patients, patient ), patients, patient7593 (one patients, patient ), and fatal hemorrhage (one patients, patient ). Bronchial complications arose in 7 of 15 recipients (46.7%) with saprophytic fungal infections, Saprophytic fungal infections of the BA in contrast to 4 of 46 (8.7%) without anastomotic infections, infection, infections, anastomotic infection (p = 0.003, Fisher exact test). Also demonstrated was a positive correlation between anastomotic infections, infection, infections, anastomotic infection and bronchial complications (Phi coefficient = 0.43; p = 0.001), while logistic regression analysis revealed that the absence of anastomotic infections, infection, infections, anastomotic infection predicted the absence of such complications (p = 0.002). The risk of developing an additional complication following an anastomotic infections, infection, infections, anastomotic infection in patients, patient with anastomotic infections, infection, infections, anastomotic infection was five times that of those recipients without an anastomotic infections, infection, infections, anastomotic infection (relative risk, 5.36; 95% confidence interval [CI], 1.82 to 15.79). The odds in favor of a bronchial complication following an anastomotic infections, infection, infections, anastomotic infection were eight times greater than in those recipients without anastomotic infections, infection, infections, anastomotic infection (odds ratio, 8.31; 95% CI, 1.96 to 35.16). CONCLUSIONS: Following LTX, saprophytic fungal infections, Saprophytic fungal infections of the BA are associated with serious airway complications.
| null |
3258_biomrc
|
Title: Genetic Dissection of the Relative Roles of Auxin and @entity15150 in the Regulation of Stem Elongation in Intact Light-Grown XXXX .
Exogenous gibberellin (GA) and auxin ( indoleacetic acid [ IAA ]) strongly stimulated stem elongation in dwarf GA1-deficient le mutants of light-grown Pisum sativum L, pea ( Pisum sativum L, pea .): IAA elicited a sharp increase in growth rate after 20 min followed by a slow decline; the GA response had a longer lag (3 h) and growth increased gradually with time. These responses were additive. The effect of GA was mainly in internodes less than 25% expanded, whereas that of IAA was in the older, elongating internodes. IAA stimulated growth by cell extension; GA stimulated growth by an increase in cell length and cell number. Dwarf lkb GA-response-mutant plants elongated poorly in response to GA (accounted for by an increase in cell number) but were very responsive to IAA . GA produced a substantial elongation in lkb plants only in the presence of IAA . Because lkb plants contain low levels of IAA , growth suppression in dwarf lkb mutants seems to be due to a deficiency in endogenous auxin . GA may enhance the auxin induction of cell elongation but cannot promote elongation in the absence of auxin. The effect of GA may, in part, be mediated by auxin. Auxin and GA control separate processes that together contribute to stem elongation. A deficiency in either leads to a dwarfed phenotype.
| null |
3260_biomrc
|
Title: Ranibizumab 0.5 mg for XXXX with Bimonthly Monitoring after a Phase of Initial Treatment: 18-Month, Multicenter, Phase IIIB RELIGHT Study.
PURPOSE: To evaluate ranibizumab 0.5 mg using bimonthly monitoring and individualized re-treatment after monthly follow-up for 6 months in participants, patients, Participants, PARTICIPANTS with visual impairment due to participants, patients, Participants, PARTICIPANTS103 ( participants, patients, Participants, PARTICIPANTS103 ). DESIGN: A phase IIIb, 18-month, prospective, open-label, multicenter, single-arm study in the United Kingdom. participants, patients, Participants, PARTICIPANTS : participants, patients, Participants, PARTICIPANTS (N = 109) with visual impairment due to participants, patients, Participants, PARTICIPANTS103 . METHODS: participants, patients, Participants, PARTICIPANTS received 3 initial monthly ranibizumab 0.5 mg injections (day 0 to month 2), followed by individualized best-corrected visual acuity (BCVA) and optical coherence tomography-guided re-treatment with monthly (months 3-5) and subsequent bimonthly follow-up (months 6-18). Laser was allowed after month 6. MAIN OUTCOME MEASURES: Mean change in BCVA from baseline to month 12 (primary end point), mean change in BCVA and central retinal thickness (CRT) from baseline to month 18, gain of >= 10 and >= 15 letters, treatment exposure, and incidence of adverse events over 18 months. RESULTS: Of 109 participants, patients, Participants, PARTICIPANTS , 100 (91.7%) and 99 (90.8%) completed the 12 and 18 months of the study, respectively. The mean age was 63.7 years, the mean duration of participants, patients, Participants, PARTICIPANTS103 was 40 months, and 77.1% of the participants, patients, Participants, PARTICIPANTS had received prior laser treatment (study eye). At baseline, mean BCVA was 62.9 letters, 20% of participants, patients, Participants, PARTICIPANTS had a baseline BCVA of >73 letters, and mean baseline CRT was 418.1 m, with 32% of participants, patients, Participants, PARTICIPANTS having a baseline CRT <300 m. The mean change in BCVA from baseline to month 6 was +6.6 letters (95% confidence interval [CI], 4.9-8.3), and after institution of bimonthly treatment the mean change in BCVA at month 12 was +4.8 letters (95% CI, 2.9-6.7; P < 0.001) and +6.5 letters (95% CI, 4.2-8.8) at month 18. The proportion of participants, patients, Participants, PARTICIPANTS gaining >= 10 and >= 15 letters was 24.8% and 13.8% at month 12 and 34.9% and 19.3% at month 18, respectively. participants, patients, Participants, PARTICIPANTS received a mean of 6.8 and 8.5 injections over 12 and 18 months, respectively. No new ocular or nonocular safety findings were observed during the study. CONCLUSIONS: The BCVA gain achieved in the initial 6-month treatment period was maintained with an additional 12 months of bimonthly ranibizumab PRN treatment.
| null |
3261_biomrc
|
Title: Heatwaves and their impact on @entity1 with XXXX , drug and mental health conditions: a discussion paper on clinical practice considerations.
AIM: This article discusses the clinical implications of adverse health outcomes derived during heatwaves for people with people46 , substance misuse and those taking prescribed medications such as people091 , various neuroleptic and anticholinergic drugs. BACKGROUND: With climate change it is predicted that the incidence of prolonged periods of extreme heat will increase. Specific adverse health outcomes associated with high environmental temperatures include heat stroke and heat exhaustion. Those at increased risk for heat-related mortality are those with chronic health conditions, including those with people46 and substance misuse. DATA SOURCES: Sources of evidence included and 'grey' literature published between 1985 and 2010, such as key texts, empirical research, public policies, training manuals and community information sheets on heat waves. DISCUSSION: Current clinical practice and clinical impact of heatwaves on those people with comorbidity is explored. This includes the physiological components of heat stress, heat regulation, and the impact of people67 and other drugs; and, ramifications and professional practice issues for those with mental health conditions and those requiring mental health medications. IMPLICATIONS FOR NURSING: Client education covering modification of the environment and the use of client heat safety action plans. Secure, accessible stores of prescribed medication are recommended and emergency substance withdrawal kits could be made available. CONCLUSION: All nurses have a responsibility to increase the capability and resilience of their clients to manage their chronic health needs during a heatwave. At these times nurses need to give extra monitoring and assistance when clients lack the capacity or resources to protect themselves.
| null |
1215_biomrc
|
Title: XXXX after non-operative management of blunt @entity99 .
BACKGROUND: The non-operative management of blunt liver trauma can be applied in almost 80% of patients, patient with this patients, patient30 , with the advantages of the need for fewer blood transfusions, less patients, patient320 , and a better survival rate, than with the operative approach. However, Liver abscess, liver abscess , as a known complication of the non-operative management of blunt liver trauma , is discussed infrequently. Therefore, we herein review our experience and describe this complication in detail. MATERIALS AND METHODS: From 1995 to 2001, 674 patients, patient were admitted to our hospital due to blunt hepatic injury, liver injury, hepatic trauma . Among these patients, patient , 279 underwent laparotomy and the remaining 395 patients, patient were treated non-operatively. Twenty-two patients, patient were identified as having Liver abscess, liver abscess , with 16 of them belonging to the operative group, and six to the non-operative group. A retrospective review of these six patients, patient and their characteristics, as well as pathogenesis, diagnosis, and the management of the liver abscesses, was conducted. RESULTS: These six patients, patient were all male, with a median age of 19.5 years (range 3-24). The median injury severity score was 16.5 (range 9-25); three patients, patient sustained grade-3 hepatic injury, liver injury, hepatic trauma , and the other three were grade 4. The main diagnostic tool was abdominal computed tomography, and the abscesses took a median of 6 days (range 1-12) to form and be diagnosed. The abscesses were usually caused by infection from mixed organisms, and an abscess resulting from Clostridium infection developed within 1 day after injury. These abscesses were treated with antibiotics and drainage, and the median length of hospital stay was 26 days (range 8-44), without mortality or long-term morbidity. CONCLUSION: Liver abscess, liver abscess as a complication of the non-operative management of blunt hepatic injury, liver injury, hepatic trauma is a rare entity, with an incidence of 1.5% (6/395). It is usually seen in severe hepatic injury, liver injury, hepatic trauma (grade 3 and above), but all our patients, patient were all treated successfully, with no mortality. However, prolonged hospitalization may be required in this patients, patient group.
| null |
1217_biomrc
|
Title: XXXX --Indian experience.
patients5 ( patients5 ) does occur in India but it is rare. No epidemiological studies have been done. The calculations based on the hospital data suggest an approximate prevalence rate of 0.17 to 1.33 per 100,000 of population in different parts of India. One hundred and five patients with clinically definite patients5 (2 proven at autopsy) and 14 patients with patients652 were seen in the Bombay region from 1957 to 1983. The mean age of onset for patients5 patients was 27.7 years. There were 60 female and 45 male patients . The clinical data in this larger series confirm the conclusions reached earlier, namely that the Indian patients5 patients are more akin to those reported from Japan and other Asian countries as compared to the West. The relative incidence of patients652 was high (6%). The optico-spinal form of patients5 was the commonest (71.4%). In patients with clinically definite patients5 there was a high incidence of optic nerve involvement, both at the onset and during the course of the disease; sensory level occurred in a large number of patients and cerebellar involvement was less frequent. patients5 in this series affected patients of all communities and different dietary habits. patients5 was more common in the higher socioeconomic group whereas patients652 was mainly seen in patients in the low socioeconomic group.
| null |
1220_biomrc
|
Title: Pseudoprogression in @entity1 with XXXX : Assessment by Using Volume-weighted Voxel-based Multiparametric Clustering of MR Imaging Data in an Independent Test Set.
UNASSIGNED: Purpose To validate a volume-weighted voxel-based multiparametric clustering, VVMC ( volume-weighted voxel-based multiparametric clustering, VVMC ) method for magnetic resonance imaging data that is designed to differentiate between pseudoprogression and early tumor progression (ETP) in patients with glioblastoma in an independent test set. Materials and Methods This retrospective study was approved by the local institutional review board, with waiver of the need to obtain informed consent. The study patients were grouped chronologically into a training set (108 patients ) and a test set (54 patients ). The reference standard was pathologic findings or subsequent clinical-radiologic study results. By using the optimal cutoff determined in the training set, the diagnostic performance of volume-weighted voxel-based multiparametric clustering, VVMC was subsequently tested in the test set and was compared with that of single-parameter measurements (apparent diffusion coefficient [ADC], normalized cerebral blood volume [nCBV], and initial area under the time-signal intensity curve). Results Interreader agreement was highest for volume-weighted voxel-based multiparametric clustering, VVMC (intraclass correlation coefficient, 0.87-0.89). Receiver operating characteristic curve analysis revealed that volume-weighted voxel-based multiparametric clustering, VVMC performed the best as a classifier, although statistical significance was not demonstrated with respect to the nCBV in the training set. In the test set, the diagnostic accuracy of volume-weighted voxel-based multiparametric clustering, VVMC was higher than that of any single-parameter measurements, but this trend reached significance only for the ADC. When the entire population was considered, volume-weighted voxel-based multiparametric clustering, VVMC had significantly better diagnostic accuracy than did any single parameter (P = .003-.046 for reader 1; P = .002-.016 for reader 2). Results of fivefold cross validation confirmed the trends in both the training set and the test set. Conclusion volume-weighted voxel-based multiparametric clustering, VVMC is a superior and more reproducible imaging biomarker than single-parameter measurements for differentiating between pseudoprogression and ETP in patients with glioblastoma . ( ) RSNA, 2015 Online supplemental material is available for this article.
| null |
1221_biomrc
|
Title: Treatment results of juvenile XXXX .
Treatment results for 36 children, Patients, patients, patient with juvenile pilocytic astrocytoma, anaplastic astrocytoma treated from 1942 through 1985 at the University of California, San Francisco, were reviewed. Twenty-two tumor, tumors were located in the posterior fossa, 10 were in the hypothalamic region, and four were in the cerebral hemispheres. Twenty-eight children, Patients, patients, patient were less than 18 years of age. The overall survival rate was 83% and 70% at 10 and 20 years, respectively. All 12 children, Patients, patients, patient who had total tumor, tumors resection remain disease-free; only two of the 12 received postoperative irradiation. The 10- and 20-year freedom-from-progression for the 19 children, Patients, patients, patient who had incomplete resection and received at least 40 Gy of postoperative irradiation was 74% and 41%, respectively. All children, Patients, patients, patient who failed treatment had local recurrence. One children, Patients, patients, patient developed diffuse meningeal seeding, after four local recurrences in the posterior fossa over a 23-year period. Six children, Patients, patients, patient failed treatment and had a repeat biopsy at the time of recurrence or at postmortem examination, and three showed histological progression of the tumor, tumors to an pilocytic astrocytoma, anaplastic astrocytoma . Based on this study and others in the literature, a protocol has been adopted whereby children, Patients, patients, patient who have total tumor, tumors resection are not treated with postoperative irradiation. children, Patients, patients, patient who have incomplete tumor, tumors resection and are older than 3 years of age are currently treated with postoperative partial-brain irradiation, to a dose of 45 to 60 Gy. In general, young children, Patients, patients, patient with incomplete resection are followed closely with computerized tomography or magnetic resonance imaging and are treated with chemotherapy or irradiation if tumor, tumors progression is documented.
| null |
1222_biomrc
|
Title: High-level expression, purification, and enzymatic characterization of truncated @entity1 plasminogen (Lys531-Asn791) in the methylotrophic yeast XXXX .
BACKGROUND: human351 is a serine protease that plays a critical role in fibrinolysis, which is a process that prevents blood clots from growing and becoming problematic. Recombinant human microplasminogen (rh human351 ) is a derivative of human351 that solely consists of the catalytic domain of human human351 and lacks the five kringle domains found in the native protein. Developing an industrial production method that provides high yields of this protein with high purity, quality, and potency is critical for preclinical research. RESULTS: The human microplasminogen gene was cloned into the pPIC9K vector, and the recombinant plasmid was transformed into human0101 . The concentration of human351 reached 510.1 mg/L of culture medium. Under fermentation conditions, the yield of rh human351 was 1.0 g/L. We purified rh human351 to 96 % purity by gel-filtration and cation-exchange chromatography. The specific activity of rh human351 reached 23.6 U/mg. The K m of substrate hydrolysis by recombinant human microplasmin was comparable to that of human human351 , while rh Plm had higher k cat /Km values than human351 . The high purity and activity of the rh human351 obtained here will likely prove to be a valuable tool for studies of its application in thrombotic diseases and human715 . CONCLUSIONS: Reliable rh human351 production (for use in therapeutic applications) is feasible using genetically modified human0056 as a host strain. The successful expression of rh human351 in human0056 lays a solid foundation for its downstream application.
| null |
3274_biomrc
|
Title: Addition of @entity506 to XXXX for treatment of @entity3964 @entity311 in Gambian @entity1 causes a significant but short-lived reduction in infectiousness for mosquitoes.
OBJECTIVES: Combination therapy using existing anti-malarials together with artesunate ( AS, CQ/AS ) has been advocated as a method to slow the spread of drug resistance. We assessed the effect on P. falciparum, Plasmodium falciparum transmissibility of the addition of AS, CQ/AS to chloroquine (CQ) in an area of The Gambia where resistance to CQ is increasing. METHODS: Gambian children, patients with acute uncomplicated P. falciparum, Plasmodium falciparum malaria were treated with either CQ monotherapy (n=120) or the combination of CQ plus three doses of AS, CQ/AS ( AS, CQ/AS ; n=352). Post-treatment sexual-stage parasitaemia was assessed during a 4-week follow-up period. Experimental infections of Anopheles gambiae s.s. mosquitoes were performed with blood from children, patients who were carrying gametocytes 7 days after starting treatment (n=69). RESULTS: The addition of AS, CQ/AS significantly reduced post-treatment prevalence and mean density of gametocytes in the first 14 days (day 7: 43.7% vs. 12.4%, 62.4/microl vs. 6.2/microl; day 14: 32.9% vs. 3.7%; 21.9/microl vs. 5.2/microl; CQ vs. AS, CQ/AS ), although by day 28 the benefits of the combination were substantially less marked (40.5% vs. 21.8%; 23.0/microl vs. 63.1/microl; CQ vs. AS, CQ/AS ). The duration of gametocyte carriage over the study period was significantly lower in the AS, CQ/AS group (5.2 days vs. 1.5 days; CQ vs. AS, CQ/AS ). The estimated infectious proportion of children, patients at day 7 was also lower in the combination group (19.2% vs. 3.4%; CQ vs. AS, CQ/AS ), as were the proportion of mosquitoes infected and mean oocyst density (11.5% vs. 0.9%; 0.3 vs. 0.01; CQ vs. AS, CQ/AS ). Treatment failure was associated with threefold and twofold higher gametocyte carriage rates during follow-up in CQ and AS, CQ/AS groups, respectively (P<0.001 in both cases), and 26-fold and 2.3-fold higher intensity of infection at day 7 among CQ- and AS, CQ/AS -treated children, patients , respectively (P=0.002 and 0.30, respectively). CONCLUSION: The benefits of adding AS, CQ/AS to CQ monotherapy in lowering gametocyte prevalence and density were transient, suggesting that the addition of AS, CQ/AS delayed, but did not prevent, the emergence of gametocytes. This is consistent with our finding that treatment failure, and thus the presence of CQ-resistant parasites, was significantly associated with a higher gametocyte carriage rate in both treatment groups. At day 7, CQ monotherapy significantly favoured transmission of resistant infections, which showed an 11-fold greater intensity of transmission compared with infections that were successfully treated. In contrast, the combination of AS, CQ/AS did not significantly favour resistant infections at day 7. We conclude that significant transmission-reduction is achieved by the combination but is not maintained because of the recrudescence of CQ-resistant parasites.
| null |
3280_biomrc
|
Title: Risk factors for XXXX and factors related to the use of DXA in Norway.
To evaluate the case-finding strategy for women, men70 in Norway, a questionnaire concerning risk factors for women, men70 and history of osteodensitometry was mailed to a population-based cohort of 6000 women, men and 6000 women, men . Suboptimal examination rates among high risk and reallocation of scanning capacity to seemingly low-risk individuals was found. PURPOSE: In Norway, a case-finding strategy for women, men70 has been used. No data exist regarding the efficacy of this approach. The aim was to examine the prevalence of risk factors for women, men70 and factors related to the use of dual X-ray absorptiometry (DXA) in Norway. METHODS: Questionnaires regarding previous history of DXA, risk factors for women, men70 and women, men74 were sent to an age-stratified, nationwide cross-sectional sample of 6000 women, men and 6000 women, men aged 40-90 years, drawn from the Norwegian Civil Registration System. RESULTS: Valid responses (6029) were included. Twenty-two point three percent of women, men and 3.8 % of women, men had been examined by DXA. Suboptimal examination rates among high risk (e.g., current/previous glucocorticoid treatment or previous low-energy women, men74 ) and reallocation of scanning capacity to seemingly low-risk individuals was found. Of all DXA, 19.5 % were reported by women, men without any risk factor for women, men70 , similarly by 16.2 % of women, men . Distance to DXA facilities and current smoking were inversely related to probability of reporting a DXA. CONCLUSIONS: Suboptimal examination rates among high risk and reallocation of scanning capacity to seemingly low-risk individuals were found. Distance to DXA, current smoking, and male sex constituted possible barriers to the case-finding strategy employed. Cheap and more available diagnostic tools for women, men70 are needed, and risk stratification tools should be employed more extensively.
| null |
1235_biomrc
|
Title: Correlation of high-resolution magic angle spinning proton magnetic resonance spectroscopy with histopathology of intact XXXX @entity1313 specimens.
High-resolution magic angle spinning proton (HRMAS 1H) magnetic resonance spectroscopy produces well-resolved spectra of metabolites from intact tissue specimens. Here we report the results of a preliminary study of 19 human human313 obtained by applying this method. Among these 19 cases were 2 low-grade anaplastic astrocytomas, anaplastic astrocytoma, astrocytomas , 1 anaplastic astrocytomas, anaplastic astrocytoma, astrocytomas , 8 glioblastomas , 6 human653 , and 2 schwannomas . In addition, autopsy human brain tissues from two subjects without any known human6 were used as normal controls. The HRMAS 1H magnetic resonance spectroscopy measurements were performed at 2 degrees C on a 400-MHz NMR spectrometer with a HRMAS speed of 2.5 kHz. From these HRMAS 1H MR spectra, we measured the concentrations of 11 metabolites, the ratios of 15 metabolites (resonances) to creatine (at 3.03 ppm), and the spin-spin relaxation time for these metabolites (resonances). Our results indicate that these parameters have the potential to characterize tumor, tumors types and grades with statistical significance as well as identify tumor, tumors biochemical characteristics. In particular, we found that compared with metabolite concentrations and metabolite spin-spin relaxation time, the metabolic ratios presented the highest sensitivity in differentiating normal tissue from tumor, tumors , as well as in distinguishing between tumor, tumors groups. Of 15 analyzed metabolic ratios, 12 showed statistical significance in differentiating normal tissue from low-grade and anaplastic astrocytomas, anaplastic astrocytoma, astrocytomas , 13 showed statistical significance in differentiating normal tissue from glioblastomas , 14 showed statistical significance in differentiating normal tissue from schwannomas , and 9 showed statistical significance in differentiating normal tissue from human653 . Moreover, our results strongly indicate that the resonance ratio of inositol (at 4.05 ppm) to creatine may help distinguish tumor, tumors type. Our results suggest that the HRMAS method for intact tissue measurement may function as an adjunct to histopathology and contribute to improved accuracy for human313 diagnoses.
| null |
3284_biomrc
|
Title: Detection of XXXX DNA in @entity3137 using in situ DNA-hybridization applied on paraffin sections.
The in situ DNA hybridization technique, carried out under stringent conditions, was used to detect human papillomavirus (HPV ) DNA of types 6, 11, and 16 in paraffin sections of 32 surgically treated oral mucosal lesions . Expression of HPV structural proteins was analyzed by means of the immunoperoxidase (IP-PAP) method. A total of 10 (31.3%) of the 32 lesions proved to express HPV antigens, which were found in 4 of 7 squamous cell papillomas , in 2 of 2 classic condylomas , in 2 of 10 papillary hyperplasias , and in 2 of 3 leukoplakia lesions, lichen planus lesion . Two of the squamous cell papillomas contained HPV 6 DNA, and 4 additional lesions were positive for HPV 11 DNA. In one of the condylomas , a double infection by HPV 6 and 11 was found, while the second was positive for HPV 11 alone. Both the HPV antigen-positive papillary hyperplasias contained HPV 6 DNA, as did the HPV antigen-positive leukoplakia lesions, lichen planus lesion . Of the latter, one was infected by HPV 6 and 11. DNA of the "high-risk" HPV 16 was contained in two lesions: one leukoplakia lesions, lichen planus lesion and one of the two squamous cell carcinomas . The results confirm the previously reported evidence of HPV involvement in oral mucosal lesions . The implications of these findings are discussed in terms of the well-established premalignant character of oral leukoplakia and oral lichen planus, although far less commonly versus leukoplakia , with special emphasis on the discovery of the "high-risk" HPV 16 in the latter as well as in oral cancer .(ABSTRACT TRUNCATED AT 250 WORDS)
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1236_biomrc
|
Title: Sexual rehabilitation in a XXXX center: diagnosis and outcome in 384 consultations.
A program of sexual rehabilitation in a cancer, malignancy center evaluated 308 women, Patients, patients, men and 76 women, Patients, patients, men , using a structured interview. The site of the cancer, malignancy was pelvic or genital in 79% of women, Patients, patients, men and 58% of women, Patients, patients, men . Most women, Patients, patients, men (73%) had one or two sessions of sexual counseling, but therapy was more intensive for about a quarter of women, Patients, patients, men . Partners were included in counseling by 28% of women, Patients, patients, men and 56% of women, Patients, patients, men . Although cancer, malignancy women, Patients, patients, men and spouses of women, Patients, patients, men reported similar rates of sexual dysfunction, sexual dysfunctions before cancer, malignancy diagnosis, after cancer, malignancy treatment husbands and wives of women, Patients, patients, men maintained stable sexual function, while dysfunctions increased dramatically in all categories except premature ejaculation for women, Patients, patients, men . women, Patients, patients, men who were older or had cancer, malignancy30 were more likely to develop arousal-phase sexual dysfunction, sexual dysfunctions . Psychological distress was correlated with rates of low sexual desire and cancer, malignancy46 in both women, Patients, patients, men and women, Patients, patients, men . The success of treatment in reversing sexual dysfunction, sexual dysfunctions was rated by the therapist in 118 cases. women, Patients, patients, men who were younger, who were not clinically depressed, and who had less conflicted marriages had more positive outcomes. Good outcome was also associated with a longer duration of treatment.
| null |
3286_biomrc
|
Title: Gender-associated differences in emergency department XXXX management.
STUDY OBJECTIVE: To determine whether participants, Patients, patients, patient, PARTICIPANTS or provider gender is associated with the number, type, and strength of medications received by emergency department participants, Patients, patients, patient, PARTICIPANTS with participants, Patients, patients, patient, PARTICIPANTS0 , participants, Patients, patients, patient, PARTICIPANTS58 . DESIGN: Prospective cohort study. SETTING: Stanford University Hospital ED participants, Patients, patients, patient, PARTICIPANTS : participants, Patients, patients, patient, PARTICIPANTS 18 years and older who arrived at the ED with a chief complaint of participants, Patients, patients, patient, PARTICIPANTS0 , participants, Patients, patients, patient, PARTICIPANTS58 between February 1, 1993, and September 30, 1993. Provider participants, Patients, patients, patient, PARTICIPANTS included medical students, interns, residents, nurse practitioners, and attending physicians. RESULTS: ED administration of analgesic versus no analgesic, strength of analgesic administered, and administration of multiple medications. The study group consisted of 190 participants, Patients, patients, patient, PARTICIPANTS , 110 of them female. The participants, Patients, patients, patient, PARTICIPANTS were evaluated by 84 providers, 60 of them male. According to the providers surveyed, female participants, Patients, patients, patient, PARTICIPANTS described more participants, Patients, patients, patient, PARTICIPANTS58 than did male participants, Patients, patients, patient, PARTICIPANTS (P < .01) and were perceived by providers to experience more participants, Patients, patients, patient, PARTICIPANTS58 (P = .03). Female participants, Patients, patients, patient, PARTICIPANTS received more medications (P < .01) and were less likely to receive no medication (P = .01). Female participants, Patients, patients, patient, PARTICIPANTS also received more potent analgesics (P = .03). Linear and logistic regression analysis showed that participants, Patients, patients, patient, PARTICIPANTS perception of participants, Patients, patients, patient, PARTICIPANTS58 was the strongest predictor of the number and strength of medications given; participants, Patients, patients, patient, PARTICIPANTS gender was not a predictor. CONCLUSION: Female participants, Patients, patients, patient, PARTICIPANTS with participants, Patients, patients, patient, PARTICIPANTS0 , participants, Patients, patients, patient, PARTICIPANTS58 describe more participants, Patients, patients, patient, PARTICIPANTS58 and are perceived by providers to have more participants, Patients, patients, patient, PARTICIPANTS58 than male participants, Patients, patients, patient, PARTICIPANTS in the ED . Female participants, Patients, patients, patient, PARTICIPANTS also receive more medications and stronger analgesics. In this study, severity of participants, Patients, patients, patient, PARTICIPANTS participants, Patients, patients, patient, PARTICIPANTS58 rather than gender stereotyping appeared to correlate most with participants, Patients, patients, patient, PARTICIPANTS58 -management practices.
| null |
1242_biomrc
|
Title: XXXX ( @entity5298 ) levels in peri-implant crevicular fluid.
BACKGROUND: Receptor activator of nuclear factor kappa B ligand, RANKL ( Receptor activator of nuclear factor kappa B ligand, RANKL ) is one of the key cytokines in the induction of osteoclastogenesis both in vitro and in vivo. Several reports indicated the presence of sRANKL in gingival crevicular fluid of patients with periodontal diseases . OBJECTIVE: To determine the presence of Receptor activator of nuclear factor kappa B ligand, RANKL in peri-implant crevicular fluid samples of implants with periimplantitis, peri-implantitis , peri-implant mucositis and healthy controls. METHODS: In this study, 40 implants were categorized as clinically healthy, peri-implant mucositis and periimplantitis, peri-implantitis according to the clinical and radiographic findings. Filter paper strips were used to collect peri-implant crevicular fluid for 30 seconds in the base of the crevice/pocket. Peri-implant crevicular fluid (PICF) samples were obtained from buccal and lingual aspects of implants. Plaque index, probing depth, gingival index and bleeding on probing were recorded at six sites per implant. Enzyme-linked immunosorbent assay (ELISA) was performed to determine the PICF levels of sRANKL. RESULTS: There were no statistically significant differences in sRANKL concentration between healthy group, peri-implant mucositis and periimplantitis, peri-implantitis (p=0.12). There were also no statistical correlation between the concentration of sRANKL and probing pocket depth (R=0.051, p=0.65), or any of the other clinical regarding (p>0.05). No differences between the mean sRANKL concentration in the buccal and lingual sites were found (p=0.693). CONCLUSION: Our results may suggest that peri-implant crevicular fluid analysis of sRANKL in conjunction with some other osteoclastogenic mediators could be further investigated in further well-designed prospective longitudinal studies on a larger-scale sample size in the evaluation of dental implants.
| null |
1246_biomrc
|
Title: [Adolescent pregnancy and the development of XXXX ].
The authors aim to investigate the incidence and severity of patients, patient468 in adolescent pregnancies (age under 17 years) and to evaluate the outcome of pregnancy and birth in this patients, patient . With this purpose we compare obstetric and neonatal results in 528 adolescents aged between 13 and 17 years with the results of a control group of mothers aged between 20 and 24 years. We used clinical observation, laboratory findings, instrumental diagnostics and scoring systems. Data were computer-processed. patients, patient468 and eclampsia was diagnosed in 17 cases (3.22%), with mild forms prevailing (2.46%). Eclampsia developed in 4 pregnant (0.76%)-an incidence differing from that cited in the literature. We are impressed by the outmost severity of eclampsia in the adolescents, with 1 case of fatal outcome. Seven of the newborns were retarded. The most frequent indications to caesarean section were placental ablation and foetal distress syndrome . Operative delivery was performed in 41.18%. One case of foetal antenatal death and one death in the early neonatal period were observed, both in mothers with eclampsia . The authors conclude that the incidence of patients, patient468 and eclampsia in adolescents is lower than in general obstetric population, but if eclampsia develops, it is fulminant and in some cases is fatal for the mother or the foetus. This grave prognosis may be related to inappropriate antenatal care in this patients, patient group.
| null |
3295_biomrc
|
Title: Meta-analyses of therapies for @entity170 . II. Meta-analysis of XXXX for the treatment of postmenopausal @entity1 .
OBJECTIVE: To review the effect of alendronate, Alendronate on bone density and women, patients74 in postmenopausal women, patients . DATA SOURCE: We searched MEDLINE, EMBASE, Current Contents, and the Cochrane Controlled trials registry from 1980 to 1999, and we examined citations of relevant articles and proceedings of international meetings. STUDY SELECTION: We included 11 trials that randomized women, patients to alendronate, Alendronate or placebo and measured bone density for at least 1 yr. DATA EXTRACTION: For each trial, three independent reviewers assessed the methodological quality and abstracted data. DATA SYNTHESIS: The pooled relative risk (RR) for women, patients74 in women, patients given 5 mg or more of alendronate, Alendronate was 0.52 [95% confidence interval (CI), 0.43-0.65]. The RR of women, patients74 in women, patients given 10 mg or more of alendronate, Alendronate was 0.51 (95% CI 0.38-0.69), an appreciably greater effect than for the 5 mg dose. We found a similar reduction in RR across nonvertebral fracture types; in particular, RR reductions for women, patients74 traditionally thought to be " osteoporotic ," such as hip and forearm, were very similar to RR reductions for "nonosteoporotic" women, patients74 . Individual studies showed similar results, reflected in the P values of the test of heterogeneity (P = 0.99 for vertebral and 0.88 for women, patients74 ). alendronate, Alendronate produced positive effects on the percentage change in bone density, which increased with both dose and time. After 3 yr of treatment with 10 mg of alendronate, Alendronate or more, the pooled estimate of the difference in percentage change between alendronate, Alendronate and placebo was 7.48% (95% CI 6.12-8.85) for the lumbar spine (2-3 yr), 5.60% (95% CI 4.80-6.39) for the hip (3-4 yr), 2.08% (95% CI 1.53-2.63) for the forearm (2-4 yr), and 2.73% (95% CI 2.27-3.20) for the total body (3 yr). Heterogeneity of the treatment effect of alendronate, Alendronate was not consistently explained by any of our a priori hypotheses; in particular, the effect was very similar in prevention and treatment studies. The pooled RR for discontinuing medication due to adverse effects for 5 mg or greater of alendronate, Alendronate was 1.15 (95% CI 0.93-1.42). The pooled RR for discontinuing medication due to gastro-intestinal (GI) side effects for 5 mg or greater was 1.03 (0.81-1.30, P = 0.83), and the pooled RR for GI adverse effects with continuation of medication was 1.03 (0.98 to 1.07) P = 0.23. CONCLUSIONS: alendronate, Alendronate increases bone density in both early postmenopausal women, patients and those with established women, patients70 while reducing the rate of women, patients74 over 2-3 yr of treatment. Reductions in women, patients74 are evident among postmenopausal women, patients without prevalent women, patients74 and have bone mineral density (BMD) levels below the World Health Organization threshold for women, patients70 . The impact on women, patients74 appears consistent across all fracture types, casting doubt on traditional distinctions between osteoporotic and women, patients74 .
| null |
3297_biomrc
|
Title: XXXX in the first 3 years of life: an electroclinical study of 46 cases.
PURPOSE: Early onset absence seizures, Childhood absence epilepsy have been considered a rare heterogeneous group with a poor prognosis. Only few children, Patients, patients may be categorized into well-known syndromes. We have evaluated electroclinical features, evolution, and the nosologic boundaries of early onset absence seizures, Childhood absence epilepsy . METHODS: Forty-six neurologically normal children, Patients, patients with absence seizures, Childhood absence epilepsy associated with bilateral, synchronic, or asynchronic, and symmetric or asymmetric spike-and-wave paroxysms with onset in the first 3 years of life were included. children, Patients, patients with abnormal neurologic examination and brain imaging were excluded from the study. KEY FINDINGS: In our study, 39 children, Patients, patients met the clinical and electroencephalography (EEG) criteria of well-defined Epilepsies, epilepsy, epileptic syndromes . absence seizures, Childhood absence epilepsy was found in 11 children, Patients, patients , myoclonic absences, benign myoclonic epilepsy, myoclonic epilepsy in infancy in 18 children, Patients, patients , eyelid myoclonic absences, benign myoclonic epilepsy, myoclonic epilepsy in 4, and Epilepsies, epilepsy, epileptic syndromes with myoclonic absences, benign myoclonic epilepsy, myoclonic epilepsy in 6. We did not find clinical and EEG criteria of well-recognized Epilepsies, epilepsy, epileptic syndromes in seven children, Patients, patients . Nine of 11 children, Patients, patients with simple absence seizures, Childhood absence epilepsy became seizure, seizures, myoclonic seizures free. All these children, Patients, patients had normal neurologic and neuropsychological evaluations. Of the 35 children, Patients, patients who had absence seizures, Childhood absence epilepsy associated with seizure, seizures, myoclonic seizures , 20 became seizure, seizures, myoclonic seizures free. Fifteen of 35 children, Patients, patients continue having seizure, seizures, myoclonic seizures . At the last visit, 20 of these 35 children, Patients, patients had normal neurologic and neuropsychological evaluations, 11 presented with mild children, Patients, patients032 , and 4 with severe children, Patients, patients032 . SIGNIFICANCE: Epilepsies, epilepsy, epileptic syndromes with absence seizures, Childhood absence epilepsy of early onset are relatively uncommon. Most of the children, Patients, patients had well-defined Epilepsies, epilepsy, epileptic syndromes with a variable evolution. The evolution depended on the Epilepsies, epilepsy, epileptic syndromes .
| null |
1252_biomrc
|
Title: Amplification/overexpression of a mitotic kinase gene in XXXX @entity150 .
BACKGROUND: The mitotic kinase-encoding gene BTAK, AuroraA, STK15 / BTAK, AuroraA, STK15 / BTAK, AuroraA, STK15 is associated with aneuploidy and transformation when overexpressed in mammalian, human, patients cells. BTAK, AuroraA, STK15 overexpression activates an unknown oncogenic pathway that involves centrosome amplification and results in missegregation of chromosomes. Because clinical prognosis and tumor, Tumors, tumors aneuploidy are tightly linked in mammalian, human, patients mammalian, human, patients50 , we examined whether increased BTAK, AuroraA, STK15 copy number and protein levels are linked to aneuploidy in mammalian, human, patients50 . METHODS: BTAK, AuroraA, STK15 protein was visualized by immunohistochemistry in 205 formalin -fixed, paraffin -embedded mammalian, human, patients mammalian, human, patients50 . BTAK, AuroraA, STK15 gene copy number was evaluated in 61 tumor, Tumors, tumors by Southern blot hybridization and in 21 of these 61 tumor, Tumors, tumors by fluorescence in situ hybridization (FISH). Copy numbers of chromosomes 3, 17, 20, and 21 were evaluated by FISH with chromosome-specific probes. BTAK, AuroraA, STK15 expression levels were related to histologic grade, stage, and DNA ploidy of the tumor, Tumors, tumors and to the mammalian, human, patients ' follow-up data. The chi-square test for association was used to analyze the relationship between BTAK, AuroraA, STK15 expression and pathologic features. All statistical tests were two-sided. RESULTS: tumor, Tumors, tumors with low levels of BTAK, AuroraA, STK15 amplification (3-4 copies) showed minimal deviation in their chromosome copy number and diploid or near-diploid total nuclear DNA content. tumor, Tumors, tumors with higher levels of BTAK, AuroraA, STK15 amplification (>4 copies) had a major increase of chromosome copy number and of their total nuclear DNA content, i.e., exhibited pronounced aneuploidy . Elevated expression of BTAK, AuroraA, STK15 was strongly associated with parameters of clinical mammalian, human, patients46 including high histologic grade (P<.001), invasion (P<.001), increased rate of metastasis (P<.001), and decreased metastasis -free (P<.001) and overall (P<.001) survival of mammalian, human, patients with mammalian, human, patients50 . CONCLUSION: BTAK, AuroraA, STK15 gene amplification and associated increased expression of the mitotic kinase it encodes are associated with aneuploidy and mammalian, human, patients46 clinical behavior in mammalian, human, patients mammalian, human, patients50 .
| null |
3303_biomrc
|
Title: XXXX from the point of view of an occupational exposure to @entity1388 in former Czechoslovakia.
Electrolytic production of aluminium in former Czechoslovakia started in the year 1953 in the iar valley in the central Slovakia. However, till 1995 the hygienic conditions for health protection were not met in the factory. It underwent a reconstruction afterwards.The authors demonstrate cases of patients141 (currently rare in Europe) in 14 metallurgists which were all disclosed in foundry workers in iar nad Hronom as to the year 2005. The occupational disease was diagnosed after 17.7 7.67 years (x SD) of exposure in the foundry.The authors describe the clinical conditions, haematological and biochemical tests (decreased level of ionising calcium was found in serum). The content of patients388 in urine was increased (254.4 130.95 mol/l). The average age of patients at the time of recognition of the professional etiology of the disease was 57.93 7.95 years. Eight patients were older than 60 years. Skeletal abnormalities were evaluated by using X-ray skiagraphy, estimating the Stage I-III of the patients141 . Typically an increase of bone density was found, the compact part of long bones was coarsed, there were calcifications of the interosseous membrane between radius and ulna and some ossifications of the sacrospinal and sacrotuberous ligaments. Twelve patients suffered sensorimotor polyneuropathy of extremities , chronic bronchitis was found in 6 patients (two of them were smokers).The last occupational case was registered in the year 2001. The authors assume that aluminium production with modern technology of better safety and protection of health of workers is the key which will make the patients141 the history in the Czech and Slovak Republic.
| null |
1256_biomrc
|
Title: [Clinical course and prognosis in XXXX ].
BACKGROUND: Establishing the value of neurological examination, and additional diagnostic methods (ultrasonography and magnetic resonance imaging of the brain) in the diagnosis and prognosis of hypoxic-ischemic encephalopathy and its treatment, tracking the clinical course, and making the prognosis of neurological development in newborn Children, infants with hypoxic-ischemic encephalopathy . METHODS: The group of 40 term newborn Children, infants with suspected intrauterine Children, infants763 was examined. All the Children, infants were prospectively followed until the 3rd year of age at the Clinic for Neurology and Psychiatry for Children, infants and Youth in order to estimate their neurological development and to diagnose the occurrence of persistent Children, infants6 . All the Children, infants were analyzed by their gestational age and Apgar score in the 1st and the 5th minute of life. They were all examined neurologically and by ultrasonography in the first week of life and, repeatedly, at the age of 1, 3, 6, 9, 12, 18, as well as in the 24th month of life. They were treated by the standard methods for this disease. Finally, all the Children, infants were examined neurologically and by magnetic resonance imaging of the brain in their 3rd year of age. On the basis of neurological finding Children, infants were divided into 3 groups: Children, infants with normal neurological finding, Children, infants with mild neurological symptomatology, and Children, infants with severe Children, infants6 . RESULTS: It was shown that neurological finding, ultrasonography and magnetic resonance imaging of the brain positively correlated with the later neurological development of the Children, infants with hypoxic-ischemic encephalopathy . CONCLUSION: Only the combined use of these techniques had full diagnostic and prognostic significance, emphasizing that the integrative approach was very important in the diagnosis of brain lesions in Children, infants .
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3307_biomrc
|
Title: The metabolic effect of @entity22482 infusion in non-insulin-dependent XXXX @entity1 .
Dodecanedioic acid ( patients8106 ) is an even-numbered patients3961 (DA). patients0989 are water-soluble substances with a metabolic pathway intermediate to those of lipids and carbohydrates . Previous studies showed that contrary to other DAs, very low amounts of patients8106 are lost with urine. The effects of 46.6 mmol of patients8106 intravenous infusion for 195 min on blood glucose levels were investigated in five patients with NIDDM, non-insulin-dependent diabetes mellitus ( NIDDM, non-insulin-dependent diabetes mellitus ), with a good metabolic compensation, and in five healthy volunteers matched for gender, age, and body mass index. Blood samples were taken every 15 min for a period of 360 min to measure glucose , insulin, C-peptide, diabetics, diabetic, diabetes mellitus178 bodies, and free fatty acid (FFA) levels, and 24-h urine samples were collected to measure patients8106 and patients133 excretion. Plasma and urinary patients8106 concentrations were determined by high-pressure liquid chromatography (HPLC). Indirect calorimetry was continuously performed both basally and during the study period. The average 24-h urinary excretion of patients8106 was 6.5% versus 6.7% of the administered dose, respectively, in NIDDM, non-insulin-dependent diabetes mellitus patients and in healthy controls. The area under the curve (AUC) values of plasma patients8106 were 279.9 +/- 42.7 mumol in NIDDM, non-insulin-dependent diabetes mellitus patients and 219.7 +/- 14.0 mumol in controls (P = ns). Plasma glucose levels significantly decreased in NIDDM, non-insulin-dependent diabetes mellitus patients during patients8106 infusion (from 7.8 +/- 0.6 to 5.4 +/- 0.8 mM at the end of the study period, P < 0.05). lactate, Lactate plasma concentration decreased in NIDDM, non-insulin-dependent diabetes mellitus patients from 3.5 +/- 0.2 to 1.5 +/- 0.1 mM (P < 0.001), whereas blood pyruvate increased at the end of the experimental session from 26.0 +/- 11.6 to 99.5 +/- 14.9 microM (P < 0.01). Free patients718 decreased in diabetics, diabetic, diabetes mellitus patients from the beginning until the end of patients8106 infusion, although this difference did not reach statistical significance. No significant increase was found between basal and final values in VO2 consumption and in the values of nonprotein respiratory quotient in both groups of subjects examined. The experimental data indicate that patients8106 infusion decreases plasma glucose levels in NIDDM, non-insulin-dependent diabetes mellitus patients to normal range without influencing plasma insulin levels. The balance between pyruvate and lactate, Lactate was affected by patients8106 infusion only in diabetics, diabetic, diabetes mellitus patients . patients8106 might represent a fuel substrate immediately available for tissue energy requirements, especially in conditions such as diabetics, diabetic, diabetes mellitus in which glucose metabolism is impaired.
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1272_biomrc
|
Title: The prognostic significance of in vitro bone marrow growth pattern in XXXX .
The growth pattern of bone marrow cells in agar culture was studied in 56 Patients, patients with untreated acute non-lymphocytic leukaemia . 4 different growth patterns were recognized: (A) colony and cluster formation, (B) growth of small clusters (3-20 cells) only but less than 600/10(5) cells, (C) growth of small clusters only but more than 600/10(5) cells, and (D) no growth in vitro. Patients, patients in group A and B had a significantly higher remission rate (23/34) than Patients, patients in group C and D (3/22). This was true also when only Patients, patients below 60 years of age were considered. The median survival time of Patients, patients in group A and B was 7.3 months and 9.4 months, and in group C and D 4.0 months and 3.3 months. Identical growth patterns were found for marrow and blood cells in 21 of 27 Patients, patients studied and the number of clusters in blood and marrow showed a significant correlation (r = +0.96, P less than 0.001). The mean 3H-labelling index, LI ( 3H-labelling index, LI ) of myeloblasts determined in 32 Patients, patients was 14.8 +/- 7.8% (SD). Patients, patients with 3H-labelling index, LI below 15% tended to have a higher remission rate than Patients, patients with 3H-labelling index, LI above 15%. It is concluded that the in vitro growth pattern at diagnosis of bone marrow cells from Patients, patients with ANLL is of value in detecting Patients, patients with a poor response to current therapeutic protocols. Such information could possibly lead to alternative cytostatic regimes in these Patients, patients .
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1273_biomrc
|
Title: Surgical interventions for XXXX in @entity1691 and the general population.
OBJECTIVE: The aim of this study was to estimate rates and type of definitive surgical interventions for Patients, patients, person790 in Swedish Patients, patients, person with Patients, patients, person691 ( Patients, patients, person691 ) compared to the general population. MATERIALS AND METHODS: This national prospective cohort study linked data from Swedish population and healthcare registries. Incidence rates and interventions for Patients, patients, person790 during follow-up in Patients, patients, person with Patients, patients, person691 were compared to general population comparator (GPC) subjects. RESULTS: In total, 8572 Patients, patients, person691 Patients, patients, person were followed for 49,959 Patients, patients, person -years and 39,639 matched GPCs were followed for 225,221 Patients, patients, person -years. Mean age at study entry was 46 years [interquartile range (IQR) 36-56 years] and 65% were male. In Patients, patients, person691 Patients, patients, person with a diagnosis of Patients, patients, person790 during the study period, 29% (72/250) underwent similar intervention for Patients, patients, person790 compared to 24% (114/466) GPCs (p = 0.21). The incidence rate ratio (RR) in overall Patients, patients, person691 Patients, patients, person was 2.9 [95% confidence interval (CI) 2.1-3.8] during a median follow-up of 6.2 years (IQR 3.2-8.6 years). With prior diagnosis of Patients, patients, person790 , the RR for Patients, patients, person691 Patients, patients, person compared to GPCs was 3.7 (95% CI 1.8-7.7); without prior Patients, patients, person790 the RR was 2.1 (95% CI 1.5-3.0). Increasing age [odds ratio (OR) 1.02, 95% CI 1.01-1.03], prior Patients, patients, person790 diagnosis (OR 3.3, 95% CI 1.97-5.62) and atherosclerotic cardiac disease (OR 2.0, 95% CI 1.03-3.91) were identified as predictors of intervention for Patients, patients, person790 . CONCLUSIONS: Patients, patients, person with Patients, patients, person691 have an almost three-fold increased risk of surgical intervention for Patients, patients, person290 , with similar management, compared to the general population.
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3326_biomrc
|
Title: [Testing of a deworming scheme for XXXX ].
In 1983 and 1984 the effect of a deworming scheme, in which horses were treated at turn out and 4 and 8 weeks later, on the egg output, larval differentiation, weight gain , herbage Infestation, infestation and in 1984, the percentages of some serum proteins were tested. In 1983 the experiment was done with 42 mares, 54 two year old male horses and 42 male yearlings, kept in groups with permanent or rotational grazing. In 1984 only 90 male yearlings were investigated. In 1983 albendazole and ivermectin were used, 1984 ivermectin . The results of the faecal examinations showed that after ivermectin treatment the number of eggs per gram faeces (EPG) remained zero or very low for a longer time. In 1983 an increase was seen during August. In 1984 the increase was observed at the end of August/beginning of September. Treatment with albendazole gave a less efficient suppression of egg output, resulting in a sharp EPG-increase at the end of July/beginning of August. After first treatment either with ivermectin or albendazole , no larvae of great Strongyles were seen. The results of the herbage Infestation, infestation on the paddocks were according to the EPGs of the horses that grazed the paddocks some time earlier. Infestation, infestation was highest in late summer and autumn, lowest in early and mid summer. No significant differences in weight gain were observed between the groups. The percentage of beta 1 + 2-globulin was highest at turn out. After first treatment it decreased, but remained stable thereafter during the season, irrespective of the reinfection in autumn. Post-mortem results of four tracers in 1984 varied from ca. 275,000-2,000,000 small Strongyles. The conclusion was drawn that under the present conditions the system was not satisfactory to prevent a reasonable worm infestation in late summer/autumn. The following advice was given: treatment of horses at least 48 hours before turn out, deworming each four weeks up till July, treatment in September and in November (also against Gasterophilus).
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3327_biomrc
|
Title: Rigid fixation of the spinal column improves scaffold alignment and prevents XXXX in the transected @entity35 spinal cord.
STUDY DESIGN: A controlled study to evaluate a new technique for spinal rod fixation after spinal cord injury in rat, rats . Alignment of implanted tissue-engineered scaffolds was assessed radiographically and by magnetic resonance imaging. OBJECTIVE: To evaluate the stability of implanted scaffolds and the extent of kyphoscoliotic deformities after spinal fixation. SUMMARY OF BACKGROUND DATA: Biodegradable scaffolds provide an excellent platform for the quantitative assessment of cellular and molecular factors that promote regeneration within the transected cord. Successful delivery of scaffolds to the damaged cord can be hampered by malalignment following transplantation, which in turn, hinders the assessment of neural regeneration. METHODS: Radio-opaque barium sulfate -impregnated poly-lactic-co-glycolic acid scaffolds were implanted into spinal transection injuries in adult rat, rats . Spinal fixation was performed in one group of animals using a metal rod fixed to the spinous processes above and below the site of injury, while the control group received no fixation. Radiographic morphometry was performed after 2 and 4 weeks, and 3-dimensional magnetic resonance microscopy analysis 4 weeks after surgery. RESULTS: Over the course of 4 weeks, progressive scoliosis was evident in the unfixed group, where a Cobb angle of 8.13 +/- 2.03 degrees was measured. The fixed group demonstrated significantly less scoliosis , with a Cobb angle measurement of 1.89 +/- 0.75 degrees (P = 0.0004). Similarly, a trend for less kyphosis was evident in the fixed group (7.33 +/- 1.68 degrees ) compared with the unfixed group (10.13 +/- 1.46 degrees ). Quantitative measurements of the degree of malalignment of the scaffolds were also significantly less in the fixed group (5 +/- 1.23 degrees ) compared with the unfixed group (11 +/- 2.82 degrees ) (P = 0.0143). CONCLUSION: Radio-opaque barium sulfate allows for visualization of scaffolds in vivo using radiographic analysis. Spinal fixation was shown to prevent scoliosis , reduce kyphosis , and reduce scaffold malalignment within the transected rat, rats spinal cord. Using a highly optimized model will increase the potential for finding a therapy for restoring function to the injured cord.
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3330_biomrc
|
Title: @entity1358 -a randomized evaluation of @entity440 vs @entity1199 , alpha-interferon (leucocyte) and XXXX .
patients, patient358 ( patients, patient358 ) has a poor prognosis. Conventional treatment strategies, including chemotherapy and hormonal therapy, have limited value. Although encouraging results have been achieved in terms of objective response using immunological manipulations, no conclusive studies yet exist with a controlled comparative evaluation of survival. Therefore, the present study was undertaken, which compared one of the present (and presumed best) treatments, patients, patient3236 ( patients, patient199 / IFN-alpha ) and tamoxifen, Tamoxifen , with a control arm of tamoxifen, Tamoxifen only. tamoxifen, Tamoxifen has been shown to potentiate in vivo anti- tumour activity of patients, patient199 , and because of its non-toxic behaviour it was included in both groups. The study was open, randomized and included seven institutions in Sweden. The patients, patient were stratified according to the different centres involved. An interim analysis was planned when a minimum of 100 patients, patient were evaluable. The 128 patients, patient finally included had a histologically documented metastatic patients, patient358 , with a life expectancy of more than 3 months, a performance status WHO 0-2 and no prior chemo- or immunotherapy. Informed consent was obtained from each patients, patient . The patients, patient randomized to the control arm (n = 63) received only tamoxifen, Tamoxifen 40 mg p.o. daily for at least 1 year or until progression. The patients, patient (n = 65) randomized to biotherapy received subcutaneous recombinant patients, patient199 , leucocyte IFN-alpha in a treatment cycle of 42 days, as well as tamoxifen, Tamoxifen p.o. In the absence of undue patients, patient37 or disease progression, these patients, patient received one additional treatment cycle of 42 days followed by maintenance treatment, consisting of 5 days therapy every 4 weeks, for 1 year, or until proven progression. Only two patients, patient in the tamoxifen, Tamoxifen -only group received immunotherapy when the disease progressed, but without any beneficial effect. All patients, patient received appropriate local treatment when indicated. The interim analysis demonstrated no survival advantage for either group, and therefore further inclusion of patients, patient was stopped. The median follow-up was 11 months (range 0.4-48 months). The final survival analysis showed no significant differences between the two treatment arms in so far as comparison from the day of diagnosis of primary disease , from the day of first evidence of metastatic spread, or from the onset of treatment. This was valid both when the evaluation was performed with regard to intention to treat and when the analysis was directed only to patients, patient that managed at least one treatment cycle (42 days) of patients, patient199 / IFN-alpha . The adverse effects were more pronounced in the patients, patient199 / IFN-alpha group. Although the number of patients, patient is limited, the results raise doubt concerning immunotherapy with patients, patient199 and IFN-alpha as a routine treatment in the management of advanced patients, patient358 . The difference in cost of drugs and health care (drug costs per patients, patient : patients, patient199 / IFN-alpha 27000 vs tamoxifen, Tamoxifen 360) as well as adverse effects caused by patients, patient199 / IFN-alpha are also factors of importance. The study emphasizes the need for more effort to find the 'optimal schedule' of immunotherapy, as well as the need for randomized controlled studies before approval of a new treatment in the routine setting.
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1286_biomrc
|
Title: Comparing the driving behaviours of individuals with @entity747 and those with XXXX .
BACKGROUND: Assessing driving aptitude in dementia Patients, patients, patient is critically important for both Patients, patients, patient and public safety. However, there have been only a few reports on the driving behaviours and accident risk of Patients, patients, patient with dementia , especially frontotemporal lobar degeneration, FTLD ( frontotemporal lobar degeneration, FTLD ). Therefore, we compared the characteristics of driving behaviours in Patients, patients, patient with frontotemporal lobar degeneration, FTLD and those with Patients, patients, patient95 ( Patients, patients, patient95 ). METHODS: The subjects were 28 frontotemporal lobar degeneration, FTLD and 67 Patients, patients, patient95 Patients, patients, patient who visited the Department of Psychiatry, Kochi Medical School Hospital. We conducted semi-structured interviews with their families and caregivers about traffic accident history and changes in Patients, patients, patient driving behaviours after dementia onset and then compared the findings between the two groups. RESULTS: Overall changes in driving behaviours were reported in 89% (25/28) and 76% (51/67) of the frontotemporal lobar degeneration, FTLD and Patients, patients, patient95 Patients, patients, patient , respectively (P = 0.17). In the frontotemporal lobar degeneration, FTLD group, difficulty in judging inter-vehicle distances, ignoring road signs and traffic signals, and distraction were reported in 50% (14/28), 61% (17/28), and 50% (14/28) of Patients, patients, patient , respectively, and 75% (21/28) Patients, patients, patient had caused a traffic accident after dementia onset. The risk of causing an accident was higher in the frontotemporal lobar degeneration, FTLD group than in the Patients, patients, patient95 group (odds ratio = 10.4, 95% confidence interval = 3.7-29.1). In addition, the mean duration between dementia onset and a traffic accident was 1.35 years in the frontotemporal lobar degeneration, FTLD group compared with 3.0 years in the Patients, patients, patient95 group (P < 0.01). CONCLUSIONS: Patients, patients, patient with frontotemporal lobar degeneration, FTLD were more likely to show dangerous driving behaviours than those with Patients, patients, patient95 , and the risk of causing a traffic accident may be higher in Patients, patients, patient with frontotemporal lobar degeneration, FTLD from an early disease stage.
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3335_biomrc
|
Title: Reduction (TELMAR) as assessed by magnetic resonance imaging in @entity1 with mild-to-moderate @entity101 --a prospective, randomised, double-blind comparison of XXXX with @entity1406 over a period of six months rationale and study design.
The Telmisartan, telmisartan Effectiveness on Left ventricular MAss Reduction (TELMAR) trial will assess the effect of the angiotensin II (Ang II) receptor blocker, Telmisartan, telmisartan , on LVH, left ventricular hypertrophy ( LVH, left ventricular hypertrophy ) compared with the b-blocker, patients406 , at similar antihypertensive doses. The rationale is that antihypertensives reduce LVH, left ventricular hypertrophy , a cardiac adaptation to pressure overload, principally by pressure-related effects. Ang II plays a key role in pressure-independent mechanisms causing LVH, left ventricular hypertrophy , and patients289 ( patients289 ) inhibitors induce more pronounced LVH, left ventricular hypertrophy regression than some other antihypertensives. Blocking Ang II Type 1 receptors may be more effective than patients289 inhibition in reducing LVH, left ventricular hypertrophy . TELMAR is a prospective, randomised, double-blind, double-dummy, parallel-group trial. A total of 140 patients (age 18 80 years) with uncontrolled essential patients01 (mean daytime systolic blood pressure [SBP] >140 mmHg or diastolic blood pressure [DBP] >90 mmHg and/or night-time SBP >120 mmHg or DBP >70 mmHg, measured by ambulatory blood pressure monitoring [ABPM]) and left ventricular mass index related to height (LVMI) >0.8 g/cm for females, >1.1 g/cm for males (defined by magnetic resonance imaging [MRI]) will be randomised to once-daily Telmisartan, telmisartan or patients406 . The Telmisartan, telmisartan dose will be 40 mg for the first two weeks, 80 mg for 5.5 months and 40 mg for the last two weeks. patients406 will be given at a dose of 47.5 mg for two weeks, 95 mg for 5.5 months and 47.5 mg for two weeks. Concomitant add-on medication with hydrochlorothiazide and amlodipine will be allowed. The primary endpoint is the percentage change in LVMI at treatment end versus baseline, using MRI. Secondary variables include blood pressure changes and response rates assessed by ABPM and manual cuff sphygmomanometry, and end-systolic wall stress, systolic patients002 ( patients002 ) and diastolic patients002 determined by MRI. A separate study was performed prior to the main trial to define the normal range of MRI data in an age-matched population.
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1288_biomrc
|
Title: A mutation affecting the @entity880 dehydrogenase locus XXXX in the @entity19 -I. Genetical and electrophoretical characterization.
(101/El x C3H/el)F1 male mice were infected intraperitoneally with the mutagen procarbazine hydrochloride and immediately caged with untreated test-stock females. Crude liver extracts from the offspring were subjected to polyacrylamide, Polyacrylamide gel isoelectric focusing, and the gels were stained for six enzymes. In the experimental group (mutagen treated spermatogonial germ-cell stage), a dominant inherited banding alteration of the lactate dehydrogenase (LDH) pattern was detected. By crossing the heterozygous mutants, homozygotes were obtained that showed much less gel staining intensity. The mutation is codominantly expressed with 100% penetrance. The banding alteration was also observed in muscle, kidney, heart, blood, brain, testis, spleen, and lung. polyacrylamide, Polyacrylamide gel electrophoresis was performed with all the tissues examined. The mutation causes the intensity of the band corresponding to LDH-A (primary molecular form in muscle) to decrease from that of the wild type, while the intensity of the bands corresponding to LDH-B (primary molecular form in heart) remains constant. It is concluded that the mutation affects the locus coding for LDH of the muscle type. Ldh-1c is proposed as the allele symbol.
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1289_biomrc
|
Title: Characterization of @entity2331 / @entity170 in XXXX : does bone density affect surgical outcome?
STUDY DESIGN: Retrospective study. OBJECTIVE: The aim of this study is to validate the prevalence of low bone mineral density, BMD ( bone mineral density, BMD ) in women, Patients, woman, patients, patient women, Patients, woman, patients, patient with women, Patients, woman, patients, patient635 and to relate that to surgical treatment outcome. Despite reports of the high prevalence of low bone mineral density, BMD among female with adolescent idiopathic, these findings have not been substantiated in any comprehensive review of women, Patients, woman, patients, patient635 women, Patients, woman, patients, patient undergoing surgical treatment. SUMMARY OF BACKGROUND DATA: It has been suggested that women, Patients, woman, patients, patient635 may predispose to women, Patients, woman, patients, patient70 and that degenerative women, Patients, woman, patients, patient635 could falsely elevate spinal bone mineral density, BMD measurements with dual energy radiograph absorptiometry (DXA). The discordance between hip and spine bone mineral density, BMD measurement using DXA has also been shown in previous cross-sectional study for adult population. METHODS: A retrospective review of 176 women, Patients, woman, patients, patient treated surgically for women, Patients, woman, patients, patient635 . bone mineral density, BMD of the lumbar spine and femoral neck were determined by DXA. women, Patients, woman, patients, patient were categorized as follows: concordance ( women, Patients, woman, patients, patient70 , osteopenia , or normal bone mineral density, BMD on both sites), minor discordance ( women, Patients, woman, patients, patient70 in one site and osteopenia in the other site), and major discordance ( women, Patients, woman, patients, patient70 in one site and normal the other site). Body mass index (BMI), preoperative Cobb angle, fusion ratio, and complication were recorded. Statistical analysis included the Student t test, (2) test, regression coefficient test, and simple linear regression. P value was set at P < 0.05. RESULTS: The mean age was 51 12 years (26-82 years). The mean T score of the hip was -1.23 0.89 and of the spine was -0.52 1.57. Major discordance in bone mineral density, BMD 7 (4%) points, minor discordance 68 (39%) points, and concordance was 101 (57%) points. There was moderate correlation between T score of hip and spine (R = 0.55P < 0.01). T score of the hip and of the spine showed 10.8% and 10.2% of the women, Patients, woman, patients, patient were osteoporotic . The mean Z score of the hip and of the spine showed comparable age and sex matched values. No correlation was observed between bone mineral density, BMD and Cobb angle (R = 0.05, P = 0.464). The fusion rate was 93% and surgical complication rate was 14.9%. No significant correlation was observed between bone mineral density, BMD and fusion (P = 0.80) complication (P = 0.13). CONCLUSION: Comparable bone density exists among women, Patients, woman, patients, patient635 women, Patients, woman, patients, patient with no correlation between bone mineral density, BMD and curve magnitude, fusion and complication rates. The difference in bone mineral density, BMD of the hip and of spine cannot be fully explained in the review. These results will guide in surgical planning, women, Patients, woman, patients, patient selection on the treatment options.
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1290_biomrc
|
Title: Hysteroscopy and @entity7548 on experimental sterilization of XXXX uterine tubes.
PURPOSE: To assess the sterilization effectiveness on uterine tube of rabbits, rabbit by the cyanoacrylate adhesive. METHODS: Hysteroscopy tubal catheterization was performed randomly in 12 animals (24 uterine tubes) assigned to the sham group (GS) and 15 animals (30 uterine tubes) to the n-butyl-cyanoacrylate (GB). The female rabbits, rabbit were observed during 30, 90 and 180 days and mated to fertile males. The no pregnant rabbits, rabbit were submitted to in vitro burst pressure test for patency by air insufflation (40 mmHg). The microscopic assessment was performed to parameters of damages in epithelium caused by the adhesive, the degree of inflammatory process, morphometry data values of tube diameter (UT) (cm), mucosa thickness (MT) and the myosalpinx thickness ( MyT ) (mm). The mucosa cells densitometry (total optical density) was expressed by the amount of DNA. The significance of the differences in histological scores and in thickness measurements were made by ANOVA test (P value < 0.05). RESULTS: In all animals of GB: the adhesive was attached to the mucosa; there was no pregnancy; no records of significant degree on inflammatory process; the patency test was negative and densitometry of DNA showed similar values to the both groups independently of observation periods. The layers thickness of GB-UT(1.118 +/- 0.117), GB-MT(0.447+/-0.247) and GB- MyT (0.853+/-0.097) were larger than the GS-UT(0.666+/-0.409), GS-MT(0.211+/-0.070) and GS- MyT (0.442+/-0.143). CONCLUSION: This approach offers a safe and feasible method of uterine tube obstruction.
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