id
stringlengths 8
11
| content
stringlengths 11
23.4k
| content_translated
stringlengths 11
10.1k
⌀ |
|---|---|---|
4712_biomrc
|
Title: Autologous fat graft as treatment of post XXXX surgical correction @entity2318 .
INTRODUCTION: Surgical limb lengthening is undertaken to correct pathological short stature . Among the possible complications related to this procedure, children, patients, patient, PATIENTS58 are a cause for both functional and cosmetic concern. Our team has already shown the efficacy of autologous fat grafting in the treatment of scars, post-surgical scars with varying aetiology, so we decided to apply this technique to scars, post-surgical scars related to surgical correction of dwarfism. A prospective study was conducted to evaluate the efficacy of autologous fat grafting in the treatment of scars, post-surgical scars in children, patients, patient, PATIENTS with short-limb dwarfism using durometer measurements and a modified children, patients, patient, PATIENTS and observer scar assessment scale (POSAS), to which was added a parameter to evaluate movement impairment . children, patients, patient, PATIENTS AND METHODS: Between January 2009 and September 2012, 36 children, patients, patient, PATIENTS (28 female and 8 male) who presented retractile and painful scars, post-surgical scars came to our unit and were treated with autologous fat grafting. Preoperative and postoperative mean durometer measurements were analysed using the analysis of variance (ANOVA) test and POSAS parameters were studied using the Wilcoxon rank sum test. RESULTS: There was a statistically significant reduction in all durometer measurements (p-value <0.05) and in all but one of the POSAS parameters (p-value <0.05) following treatment with autologous fat grafting. DISCUSSION: Surgical procedures to camouflage scars, post-surgical scars on lower limbs are not often used as a first approach and non-surgical treatments often lead to unsatisfactory results. In contrast, our autologous fat grafting technique in the treatment of scars, post-surgical scars has been shown to be a valuable option in children, patients, patient, PATIENTS with short-limb dwarfism . CONCLUSION: There was a reduction of skin hardness and a clinical improvement of all POSAS parameters in all children, patients, patient, PATIENTS treated. Moreover, the newly introduced POSAS parameter appears to be reliable and we recommend that it is included to give a more complete evaluation of children, patients, patient, PATIENTS perception.
| null |
616_biomrc
|
Title: XXXX prevents age-related aortic stiffening and vascular resistance in association with reduced collagen glycation.
An increase in oxidative chemical modifications of tissue proteins by advanced glycation end products (AGEs) and advanced lipoxidation end products (ALEs) has been implicated in normal aging. Pyridoxamine (PM), one of the three natural forms of vitamin B(6) , has been identified as an inhibitor of AGE/ALE products formed during the autoxidation of carbohydrates and peroxidation of lipids. The current study seeks to determine whether PM intervention could prevent the age-related aortic stiffening and vascular resistance through its ability to inhibit the pathogenic cross-linking of glycated collagen. Male Fisher 344 rats at 15 months were treated daily with PM (1 g l(-1) in drinking water) for 5 months and compared with the age-matched, untreated controls at 20 months. Pulsatile aortic pressure and flow signals were measured to perform the vascular impedance analysis. The anti-AGE antibody 6D12 was used to detect glycation-derived modification of aortic collagen, using protein blotting analysis. PM therapy attenuated the age-related increase in total peripheral resistance. An increase in wave transit time and aortic compliance by PM indicated that the drug improved aortic distensibility of the aged vasculature. This paralleled its reduction of AGE-collagen cross-links on aortas. Treatment of the old animals with PM also prevented the age-induced augmentation in vascular load imposed on the heart, as evidenced by an increased wave transit time and a decreased wave reflection factor. These findings suggest a partial role of PM in improving arterial mechanics by targeting the pathogenic formation of AGE-induced aortic collagen cross-links in old rats .
| null |
4716_biomrc
|
Title: [Smoking prevalence, @entity1239 @entity734 and effects of low cost cigarette sale among military healthcare personal in Turkish XXXX ].
Health professionals, particularly clinicians and nurses in the community have an important role in preventing to start smoking. In our study; we aimed to determine the prevalence of cigarette smoking, participants239 dependence, Dependence level and the effects of low price tobacco sale among healthcare personal in a military hospital. A questionnaire was applied to healthcare personal, which evaluates their smoking habits, participants239 dependence, Dependence level with Fagerstr m Test for participants239 dependence, Dependence (FTND) and the effects of low cost cigarette sale on smoking habits. Seventy male and 46 female among 138 healthcare personals (84%) responded to the questionnaire. Mean age of participants was 33.7 5.6. Among all participants , 53.4% were smoking. There was no significant difference between male and female participants in case of smoking prevalence (p> 0.05). Seven participants who started smoking regularly after they appointed to Turkish participants392 explained why they started smoking as secondary to lower cigarette prices in this country. 48.3% of participants (40% of male smokers and 59.3% of female smokers) reported increased cigarette consumption as a result of low cost cigarette sales. There was a significant difference between male and female participants in case of increase in cigarette consumption (< 0.05). According to results of FTND, about 70% of participants were low and very low-dependant, and about 22% were high and very high- dependant smokers. Smoking prevalence of healthcare personal who participated in our study was higher than that reported for community and for other healthcare personal.
| null |
4720_biomrc
|
Title: 3-[4-(3-Trifluoromethyl-phenyl)-piperazin-1-yl]-dihydrofuran-2-one and pregabalin attenuate tactile @entity1931 in the XXXX model of @entity8638 .
PURPOSE: There is a strong medical demand to search for novel, more efficacious and safer than available, analgesics for the treatment of neuropathic pain . This study investigated antinociceptive activity of intraperitoneally administered 3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-dihydrofuran-2-one ( LPP1 ) and pregabalin in the chronic constriction injury, CCI ( chronic constriction injury, CCI ) model of neuropathic pain in mice and evaluated these drugs' influence on motor coordination. In addition, microscopic examinations of the sciatic nerve were performed to assess, if a surgical method or drug treatment caused changes in the structure of this nerve. Moreover, the alterations of nerve growth factor (NGF) content after drug treatment were assessed. METHODS: Antiallodynic and antihyperalgesic activities of LPP1 and pregabalin were assessed in the von Frey and hot plate tests. Motor-impairing properties were evaluated in the rotarod test. Microscopic examinations of the sciatic nerve were performed using electron microscope. In immunohistochemical assays the content of NGF in the sciatic nerve after single or repeated administration of test drugs was assessed. RESULTS: Microscopic examinations of the sciatic nerve revealed ultrastructural changes in nerve fibers indicating for neurodegenerative processes induced by chronic constriction injury, CCI . Seven days after chronic constriction injury, CCI surgery LPP1 and pregabalin reduced tactile allodynia in von Frey test (ED50 values were 1.5 and 15.4 mg/kg, respectively). None of the test drugs at dose range 0.5-100 mg/kg induced motor deficits in the rotarod test. In immunohistochemical assays repeated doses of pregabalin and LPP1 elevated NGF content. CONCLUSIONS: LPP1 has antiallodynic properties and is an interesting lead structure in the search for novel analgesics used in neuropathic pain .
| null |
4724_biomrc
|
Title: Tracheal Resection With Primary XXXX .
The aim of our study was to present our retrospective experience in the single-stage surgical reconstruction of 21 TS, tracheal stenosis ( TS, tracheal stenosis ) patients during the last 17 years, considering the characteristics of the treated stenosis , surgical procedures performed, and postoperative outcomes and complications. All demographic and clinical data were collected retrospectively. Chest and neck computed tomography (CT) scans were performed to assess the stenosis , including length, location, and glottic involvement. The stenotic area was evaluated endoscopically according to an adapted Myer and Cotton grading scale. The aetiology of the ( TS, tracheal stenosis ) was intubation related in 18 patients and idiopathic in three patients . The duration of intubation was 13.00 6.83 days (range, 1 hour to 27 days). According to the Myers- Cotton classification, mean stage of stenosis for the study group was 3.33 0.66 (range, 2-4). Mean length of the stenosis was 2.05 0.80 (range, 1-3.5) cm. The mean number of stenotic segment involved was 3.67 1.24 (range, 2-6). Mean follow-up for the study group, excluding two patients who died in the postoperative period, was 57 (range, 12-326) months. Of the 19 patients who survived, postoperative decannulation was achieved in 16 patients (76.19%), and decannulation was not achieved in 3 patients (14.29%) who are still on a T-tube. Of the 16 patients who are decannulated successfully, additional procedures were applied in 9 patients . Segmental resection with primary anastomosis is an effective method and can be used as the first option in selected patients of ( TS, tracheal stenosis ).
| null |
629_biomrc
|
Title: A phase II trial of brachytherapy alone following lumpectomy for stage I or II XXXX : initial outcomes of RTOG 9517.
UNASSIGNED: 565 Background: In order to shorten the conventional 6-7 week radiation treatment time, and to treat only the tissue at greatest risk for recurrence, this phase II trial evaluates partial breast irradiation with 4-5 days of interstitial brachytherapy as an alternative to external beam. METHODS: Eligibility criteria included patients (pts) with invasive <= 3cm patients137 , 0-3 positive axillary nodes with no extracapsular extension and at least 6 nodes removed, negative surgical margins, no residual suspicious microcalcifications, no extensive intraductal component, and no patients413 . After lumpectomy and axillary dissection, pts were treated with either high (34 Gy in 10 fractions over 5 days) or low (45 Gy in 3.5-5 days) dose rate ( HDR or LDR) brachytherapy. Treatment volume was the lumpectomy cavity plus 2cm, except where limited by chest wall or skin. Systemic therapy was given after brachytherapy at physician discretion. Endpoints included local and regional control, disease-free (DFS) and patients349 ( patients349 ). RESULTS: One hundred pts were enrolled and one was ineligible because only a sentinel node was removed. Median follow-up is 3.7 years, range 0.6-5.7. Eighty-seven pts had T1 and 12 had T2 tumor, tumors . Seventy-nine were pathologically N0 and 20 were N1. The actuarial 4-year breast and nodal recurrence rate is 3% (3 pts, all HDR , T1N0 x2 and T1N1) and 3% (2 pts, both HDR , T1N0 x2), respectively. Distant metastasis occurred in 6 pts, 3 T1N0 and 3 T2N1, for an actuarial 4-year rate of 6%, HDR 8% and LDR 4%. DFS and patients349 were 85% and 93% at 4 years (82% and 95% HDR , 90% and 90% LDR). Contralateral breast cancer developed in 3 pts, 1 HDR and 2 LDR. Six pts had non-breast second primaries, 4 HDR and 2 LDR. CONCLUSIONS: We conclude that partial breast brachytherapy on this RTOG trial yields excellent tumor, tumors control at this early analysis (<1% local failure per year), warranting support for a future phase III trial. [Table: see text].
| null |
2676_biomrc
|
Title: Expression of @entity1722 , @entity876 , XXXX , @entity589 , @entity517 and Ki-67 in apocrine metaplasia and apocrine change within sclerosing adenosis of the breast.
Molecular evidence has recently suggested a number of different pathways leading to the development of ductal carcinoma of the breast, breast carcinomas . The links between atypical ductal hyperplasia and low-grade ductal carcinoma in situ and lobular neoplasia, lobular carcinoma and situ and lobular neoplasia, lobular carcinoma are well known pathologically, but high-grade in situ and invasive carcinomas appear to have a different biological oncogenetic pathway. Morphologically there is a similarity between apocrine cells and some cases of high-grade ductal carcinoma . In order to investigate this possibility a number of different biological markers known to occur in high-grade ductal carcinoma of the breast, breast carcinomas were assessed in both apocrine metaplasia (APM) and a putative premalignant lesion called apocrine change within sclerosing adenosis ( AA ). In 64 cases of APM and 18 cases of AA we examined for expression of c-erbB2 , p53 , Bcl-2 , Bax , c-myc and Ki-67 proteins using immunocytochemistry. c-erbB2 expression was seen in 55.6% of AA cases and in 10.9% of APM cases. p53 expression was detected in 27.8% of AA cases but only 1.6% of APM cases. All cases of AA and APM were negative for the anti-apoptotic protein Bcl-2 , but all the APM and 33.3% of AA cases showed cytoplasmic positivity for Bax , a pro-apoptotic protein. All the cases of AA and APM were positive for c-myc oncoprotein, however, the mean percentage of nuclear positivity was 50% in AA and 37% in cases of APM cases. The mean percentage positivity for Ki-67, a proliferation associated antigen, was 3.6% in AA and 1.3% in APM. The results indicate that a subset of breast lesions containing APM epithelium show abnormal oncoprotein and apoptosis-related protein expression and have a higher proliferation rate.
| null |
2681_biomrc
|
Title: Endoscopic-assisted laparoscopic resection for XXXX .
BACKGROUND: Laparoscopic resection is considered the treatment of choice for gastric subepithelial tumors . Occasionally, it is necessary to perform an intraoperative gastroscopy to localize the lesion. There are no data in the literature addressing the factors that can predict when a combined laparoscopic-endoscopic approach will be needed. METHODS: A retrospective cohort study using a prospectively collected database was conducted. From January 2005 to December 2013, all the women, patients, men undergoing a laparoscopic gastric resection for tumor, subepithelial tumors, tumors irresectable by endoscopy were reviewed. Potential predictive factors for the need of an intraoperative endoscopy were analyzed. RESULTS: Thirty-eight consecutive women, patients, men (22 women, patients, men and 16 women, patients, men ) with a mean age of 67 (41-86) years underwent laparoscopic gastric resection for tumor, subepithelial tumors, tumors . Fourteen (36.8 %) women, patients, men required intraoperative endoscopic assessment. The only significant factors related to the need of endoscopic assessment during surgery were tumor, subepithelial tumors, tumors growth pattern (P = 0.002) and size (P = 0.001). CONCLUSIONS: An accurate description of tumor, subepithelial tumors, tumors growth pattern and size by EUS is recommended in the preoperative assessment of gastric subepithelial tumors . Small tumor, subepithelial tumors, tumors ( <=18 mm) with an intraluminal growth may need a combined endoscopic-assisted laparoscopic management.
| null |
4731_biomrc
|
Title: Lack of Association of Clinical Factors (SAMe-TT2R2) with XXXX / @entity5058 Genotype and Anticoagulation Control Quality.
BACKGROUND AND PURPOSE: Advantages of new oral anticoagulations may be greater in atrial fibrillation, AF ( atrial fibrillation, AF ) patients of poor anticoagulation control with patients229 . The SAMe-TT2R2 scoring system, based on clinical variables, was recently developed to aid in identifying these patients . In this study, we investigated the association of this clinical composite score with genetic factors related patients229 dosing and the quality of anticoagulation control. METHODS: Clinical and genetic data were collected from 380 consecutive Korean patients with atrial fibrillation, AF (CHA2DS2-VASc score, 3.5 1.8) who were followed for an average of 4 years. We evaluated factors associated with time in therapeutic range (TTR, INR 2-3), including the CYP2C9 and VKORC1 genotypes and the SAMe-TT2R2 score (Sex female, Age <60 years, Medical history [>two co-morbidities], Treatment [interacting drugs, e.g., amiodarone ], Tobacco use within 2 years [doubled], and Race non-white [doubled]). RESULTS: The average SAMe-TT2R2 score was 3.4 0.9, range 2-7; and 153 patients (40.2%) had SAMe-TT2R2 scores >= 4. Time in specific INR ranges varied depending on the VKORC1 genotype but not with the CYP2C9 genotype or the SAMe-TT2R2 score. TTR was higher in patients with the VKORC1 1173C>T than in VKORC1 TT (61.7 16% vs. 56.7 17.4%, P=0.031). Multivariate testing showed that VKORC1 genotype but not the SAMe-TT2R2 score was significantly associated with labile INRs. There was no correlation between the SAMe-TT2R2 scores and pharmacogenetic data. CONCLUSIONS: A genetic factor, but none of the common clinical and demographic factors, as combined in the SAMe-TT2R2 score, was associated with the quality of anticoagulation control in Korean patients with atrial fibrillation, AF .
| null |
2685_biomrc
|
Title: XXXX ( @entity1311 ) in the treatment of lung cancer: the Eastern Cooperative Oncology Group experience.
Two phase II studies of patients, human311 involving patients, human with advanced patients, human149 ( patients, human149 ) have been completed. The first study, conducted by the Eastern Cooperative Oncology Group (ECOG), involved 25 previously untreated patients, human who received intravenous (i.v.) patients, human311 250 mg/m2 over 24 hours every 3 weeks. Among 24 evaluable patients, human with stage IV disease, Cancer , 5 partial responses (21%) were observed, median survival was 24.1 weeks, and 1-year survival was approximately 45%. Common patients, human37 included patients, human431 (66% grade 4), neurotoxicity (28% grade 3), and patients, human370 (12.5% grade 3). The second trial, conducted at the M.D. Anderson stage IV disease, Cancer Center, yielded similar results. Twenty-seven previously untreated patients, human with stage IV disease, Cancer received patients, human311 200 to 250 mg/m2 i.v. over 24 hours every 3 weeks, yielding 1 complete response and 5 partial responses (24%) in 25 evaluable patients, human . The major patients, human37 was patients, human431 . No patients, human370 was seen. For the past several years ECOG has tested several agents against previously untreated patients, human149 , and none has demonstrated a response rate greater than 10%, other than patients, human311 . Given these results, the ECOG plans to conduct a three-arm phase III study involving patients, human with advanced patients, human149 comparing 'standard' cisplatin / etoposide chemotherapy to two patients, human311 -containing arms: (1) patients, human311 135 mg/m2 i.v. over 24 hours plus cisplatin 75 mg/m2 i.v.; (2) patients, human311 250 mg/m2 i.v. over 24 hours plus cisplatin 75 mg/m2 i.v. plus recombinant patients, human patients, human261 .(ABSTRACT TRUNCATED AT 250 WORDS)
| null |
2686_biomrc
|
Title: Arterial pressure allows monitoring the changes in cardiac output induced by volume expansion but not by XXXX .
OBJECTIVE: To evaluate to which extent the systemic arterial pulse pressure could be used as a surrogate of cardiac output for assessing the effects of a fluid challenge and of Patients, patients, PATIENTS063 . DESIGN: Observational study. SETTING: Medical intensive care unit. Patients, patients, PATIENTS : Patients, patients, PATIENTS with an Patients, patients, PATIENTS457 who received a fluid challenge (228 Patients, patients, PATIENTS , group 1) or in whom Patients, patients, PATIENTS063 was introduced or increased (145 Patients, patients, PATIENTS , group 2). INTERVENTIONS: We measured the systolic, diastolic, and mean arterial pressure, pulse pressure, and the transpulmonary thermodilution cardiac output before and after the therapeutic interventions. MAIN RESULTS: In group 1, the fluid challenge significantly increased cardiac output by 24% 25%. It significantly increased cardiac output by >= 15% (+35% 27%) in 142 Patients, patients, PATIENTS ("responders"). The fluid-induced changes in cardiac output were correlated with the changes in pulse pressure (r = .56, p < .0001), systolic arterial pressure (r = .55, p < .0001), diastolic arterial pressure (r = .37, p < .0001), and mean arterial pressure (r = .52, p < .0001). At multivariate analysis, changes in pulse pressure were significantly related to changes in stroke volume (multiple r = .52) and to age (r = .12). A fluid-induced increase in pulse pressure of >= 17% allowed detecting a fluid-induced increase in cardiac output of >= 15% with a sensitivity of 65[56-72]% and a specificity of 85[76-92]%. The area under the receiver operating characteristic curves for the fluid-induced changes in mean arterial pressure and in diastolic arterial pressure was significantly lower than for pulse pressure. In group 2, the introduction/increase of Patients, patients, PATIENTS063 significantly increased cardiac output by 14% 18%. The changes in cardiac output induced by the introduction/increase in the dose of Patients, patients, PATIENTS063 were correlated with the changes in pulse pressure and systolic arterial pressure (r = .21 and .29, respectively, p = .001) but to a significantly lesser extent than in group 1. CONCLUSIONS: Pulse pressure and systolic arterial pressure could be used for detecting the fluid-induced changes in cardiac output, in spite of a significant proportion of false-negative cases. By contrast, the changes in pulse pressure and systolic arterial pressure were unable to detect the changes in cardiac output induced by Patients, patients, PATIENTS063 .
| null |
638_biomrc
|
Title: Hysterectomy and predictors for opioid prescription in a XXXX clinic sample.
OBJECTIVES: To describe the prevalence of hysterectomy for women, patients, patient, PARTICIPANTS aged 18-45 seeking treatment at a women, patients, patient, PARTICIPANTS118 clinic, to describe women, patients, patient, PARTICIPANTS characteristics ( women, patients, patient, PARTICIPANTS58 intensity, age, smoking status, hormone replacement status, and psychosocial factors) based on opioid and hysterectomy status, and to determine whether hysterectomy status predicted receipt of opioid prescription. DESIGN: Retrospective cross-sectional chart review. women, patients, patient, PARTICIPANTS : Total 323 new female women, patients, patient, PARTICIPANTS aged 18-45 who completed the Brief women, patients, patient, PARTICIPANTS58 Inventory-Short Form at initial evaluation at a women, patients, patient, PARTICIPANTS118 clinic during a 12-month period (July 2008-June 2009). MEASURES: Data were collected from the Brief women, patients, patient, PARTICIPANTS58 Inventory and medical charts. Variables included opioid prescription, average women, patients, patient, PARTICIPANTS58 intensity, women, patients, patient, PARTICIPANTS58 type, age, hysterectomy status, smoking status, and women, patients, patient, PARTICIPANTS58 across domains measured by the Brief women, patients, patient, PARTICIPANTS58 Inventory. The association of opioid prescription with hysterectomy and other factors were determined by logistic regression. RESULTS: Prevalence of hysterectomy was 28.8%. Average women, patients, patient, PARTICIPANTS58 intensity was not associated with either hysterectomy or opioid prescription status. However, hysterectomy and high levels of women, patients, patient, PARTICIPANTS58 were significantly and independently associated with opioid prescription after adjusting for age and women, patients, patient, PARTICIPANTS58 intensity. More than 85% of women, patients, patient, PARTICIPANTS with hysterectomy and high women, patients, patient, PARTICIPANTS58 had opioid prescription. CONCLUSIONS: Hysterectomy may confer risk for women, patients, patient, PARTICIPANTS58 and opioid prescription in women, patients, patient, PARTICIPANTS 45 and younger. More research is needed to understand 1) how women, patients, patient, PARTICIPANTS characteristics influence prescribing patterns and 2) the specific medical risks and consequences of chronic opioid therapy in this population.
| null |
642_biomrc
|
Title: Genome-wide allelotypes of familial pancreatic @entity420 and familial and XXXX .
PURPOSE: Most tumor, familial and sporadic pancreatic cancers, cancers, familial cancer, neoplasms, familial and precursor neoplasms susceptibility genes are tumor, familial and sporadic pancreatic cancers, cancers, familial cancer, neoplasms, familial and precursor neoplasms suppressor genes that are biallelically inactivated in familial tumor, familial and sporadic pancreatic cancers, cancers, familial cancer, neoplasms, familial and precursor neoplasms through somatic deletion of the wild-type allele. Identifying the genomic losses that occur in familial pancreatic cancers, pancreatic cancers, familial pancreatic adenocarcinoma, pancreatic neoplasms, pancreatic cancer , particularly those that occur in tumor, familial and sporadic pancreatic cancers, cancers, familial cancer, neoplasms, familial and precursor neoplasms , may help localize the genes responsible for familial pancreatic cancers, pancreatic cancers, familial pancreatic adenocarcinoma, pancreatic neoplasms, pancreatic cancer susceptibility. EXPERIMENTAL DESIGN: Normal and neoplastic tissue DNA was isolated from fresh-frozen surgically resected tissues from 20 patients with primary familial pancreatic cancers, pancreatic cancers, familial pancreatic adenocarcinoma, pancreatic neoplasms, pancreatic cancer (defined as having at least one first-degree relative with familial pancreatic cancers, pancreatic cancers, familial pancreatic adenocarcinoma, pancreatic neoplasms, pancreatic cancer ), 31 with sporadic intraductal papillary mucinous neoplasms ( IPMN ), and 7 with familial IPMNs using laser capture microdissection. Microdissected DNA was whole genome amplified using multiple strand displacement. Genome-wide allelotypes were determined using 391 microsatellite markers. The accuracy of microdissection and fidelity of the whole genome amplification were determined by comparing the genotypes of microdissected primary familial pancreatic cancers, pancreatic cancers, familial pancreatic adenocarcinoma, pancreatic neoplasms, pancreatic cancer to the genotypes of xenografts derived from these tumor, familial and sporadic pancreatic cancers, cancers, familial cancer, neoplasms, familial and precursor neoplasms and by comparing the results of amplified to nonamplified specimens. RESULTS: The concordance of genotypes between LCM whole genome amplified primary familial pancreatic cancers, pancreatic cancers, familial pancreatic adenocarcinoma, pancreatic neoplasms, pancreatic cancer and their corresponding familial pancreatic cancers, pancreatic cancers, familial pancreatic adenocarcinoma, pancreatic neoplasms, pancreatic cancer xenograft DNAs was 98%. Among the 20 primary familial pancreatic adenocarcinomas , we found a high prevalence of loss of heterozygosity (LOH) with an average fractional allelic loss (FAL) of 49.9% of an aggregate of 2,378 informative markers. The level of FAL in the IPMNs (10%) was significantly lower than in the pancreatic adenocarcinomas . The most common locus of LOH in the IPMNs was at 19p (LOH at 24% of markers). The regions of frequent allelic loss observed in the familial pancreatic cancers, pancreatic cancers, familial pancreatic adenocarcinoma, pancreatic neoplasms, pancreatic cancer were similar to those found in sporadic familial pancreatic cancers, pancreatic cancers, familial pancreatic adenocarcinoma, pancreatic neoplasms, pancreatic cancer . CONCLUSIONS: The allelic loss patterns of tumor, familial and sporadic pancreatic cancers, cancers, familial cancer, neoplasms, familial and precursor neoplasms and IPMNs provide clues as to the genomic locations of tumor, familial and sporadic pancreatic cancers, cancers, familial cancer, neoplasms, familial and precursor neoplasms suppressor genes inactivated in these tumor, familial and sporadic pancreatic cancers, cancers, familial cancer, neoplasms, familial and precursor neoplasms .
| null |
4738_biomrc
|
Title: [ XXXX , vector of the dengue virus: spatio-temporal structure of its genetic variation].
Aedes aegypti is the main vector of dengue viruses. Methods for limiting the spread of dengue outbreaks are currently based on vector control. Estimates of population genetic organization and gene flow with respect to vector capacity have provided great insights into dengue epidemiology. In Vietnam, dengue hemorrhagic fever was detected in the 1950's and becomes today the major problem of public health. Among factors influencing dengue epidemiology, ecological disturbances have a direct impact on vectorial system functioning. Human activities through urbanization creating sanitary conditions are convenient to the vector proliferation and then, to dengue endemisation . To assess the role of the vector in the changing pattern of dengue in South-East Asia, we studied the genetic differentiation and the vector competence towards Human9158 at two scales: at a spatial level (a local scale (i.e., Ho Chi Minh City) and a regional scale (i.e., Cambodia, Thailand and South Vietnam) and at a temporal scale. This study allows to propose a model of Ae. aegypti population functioning according space and time. Dynamics of dengue virus diffusion in relation with the vector, depend on the population genetic composition and its evolution.
| null |
644_biomrc
|
Title: Laparoscopic resection of advanced XXXX .
BACKGROUND: Palliative resection of the primary stage I tumours, stage I cancers, tumour in asymptomatic patients with stage IV patients4 is associated with improved survival and fewer complications. Laparoscopic surgery is widely employed in the curative treatment of patients4 , but its value in advanced patients4 remains unclear. METHODS: All patients who underwent laparoscopic resection of primary patients4 in this unit between June 1991 and Jan 2010 were entered into a prospective computerized database. Outcomes for patients with laparoscopic resection of stage IV patients4 were compared with those of patients who had laparoscopic surgery for stage I disease. RESULTS: Some 185 patients with stage IV patients4 who underwent laparoscopic resection were compared with 310 patients who had stage I patients4 . Some 94 1 and 98 4 per cent of operations respectively were completed laparoscopically. Hospital stay was slightly longer in the group with stage IV disease (mean 6 2 versus 5 3 days; P = 0 091). The 30-day mortality rate was 2 7 per cent in patients with stage IV disease and 0 6 per cent in those with stage I tumours, stage I cancers, tumour (P = 0 061). There was no difference in complications. One-year survival rates were 77 8 and 99 0 per cent respectively (P < 0 001). CONCLUSION: Short-term outcomes after laparoscopic surgery for stage IV patients4 in selected patients are equivalent to those for stage I tumours, stage I cancers, tumour .
| null |
645_biomrc
|
Title: @entity581 in XXXX .
malignancies81 have always had a major role in the treatment of gynecologic infections, infections . This therapeutic emphasis has been based upon the bactericidal activity of the malignancies81 against gram-negative aerobes. This group of organisms is important to the gynecologist because of their frequent isolation from soft tissue, urinary sites, and the bloodstream in women, patients with nosocomial or community-acquired malignancies280 . In the past decade, there has been increasing clinical awareness of the multi-bacterial nature of these soft tissue malignancies280 . A major therapeutic change directed against gram-negative anaerobes has been the substitution of more effective agents like clindamycin or metronidazole for the women, patients14 arm of the older women, patients14 - aminoglycoside combination. The majority of women, patients320 treated by gynecologists occur in women, patients who are younger and usually healthier than those with similar gynecologic infections, infections who are treated by general surgeons. Consequently, in many instances, single drug therapy with a malignancies898 (usually cefoxitin) is adequate, if combined with surgical drainage when indicated. However, there is an increasingly larger group of women, patients who are significantly older and who may also have pelvic malignancies . In addition, they may be immunocompromised. Infections in this group mandate the use of the most effective antimicrobial agents that will cover the broadest spectrum. When anaerobic bacteria are involved, either clindamycin or metronidazole are acceptable choices; for aerobic gram-negative organisms, an aminoglycoside should be used. Recent studies suggest that amikacin, Amikacin may be the best choice, since it is associated with a low level of bacterial resistance and has been shown to reduce levels of resistance to other malignancies81 . amikacin, Amikacin has become the "gold standard" for comparisons with any new cephalosporins or penicillins. New developments will modify the use of malignancies81 in the future. The expansion of oncology care with immune-system-modifying chemotherapy and radiation will expose women, patients to the dangers of gram-negative sepsis . malignancies81 are a logical part of the initial therapeutic regimen for these septic women, patients . On the other hand, the majority of gynecologic women, patients with malignancies280 are young and healthy. Recent studies have demonstrated that as many as 40 percent of these women, patients will be underdosed by standard treatment regimens based upon ideal body weight. This means that women, patients receiving malignancies81 will require monitoring of peak and trough levels to insure therapeutic drug levels.(ABSTRACT TRUNCATED AT 400 WORDS)
| null |
4742_biomrc
|
Title: @entity6309 kinetics after single and multiple dosing in @entity1 with XXXX .
The pharmacokinetics of ibopamine, Ibopamine after single and multiple dosing was studied in 20 patients with congestive heart failure, CHF ( congestive heart failure, CHF ) of NYHA functional class II. ibopamine, Ibopamine 100 mg was given 3 times a day for 7 days in 6 patients and for 30 days in the other 14 patients . Plasma pharmacokinetics of total (mainly conjugated) and free patients4524 was studied after the first dose and on the 3rd, 7th and 30th days of treatment. The urinary recoveries of total patients4524 , HVA and DOPAC were measured in 5 patients for 24 h after ibopamine, Ibopamine ingestion on the 1st and 30th days. Plasma pharmacokinetics of ibopamine, Ibopamine did not vary during the repeated administration of the drug. In the course of the treatment, total patients4524 elimination t1/2 showed no significant variations. The build-up of Cmax, Cmin and AUC of total patients4524 observed after multiple dosing was as expected on the basis of the interval adopted between the doses of ibopamine, Ibopamine and of the elimination t1/2 of total patients4524 . Pharmacokinetic parameters of free patients4524 did not show significant variations during the course of the treatment. The amounts of HVA and DOPAC recovered in urine on the 1st and 30th days of treatment were similar while the amount of total patients4524 was greater on the 30th day, the increment mainly reflecting a partial carry over of the less rapidly excreted conjugated patients4524 from the last previous doses. The results obtained for free patients4524 plasma levels and for the urinary recoveries of ibopamine, Ibopamine metabolites thus indicated that no saturation of the enzymes involved in ibopamine, Ibopamine metabolism occurred.
| null |
647_biomrc
|
Title: Early immobilization of hindleg muscles of dystrophic XXXX : short-term and long-term effects.
Hindleg muscles of normal and dystrophic mice were immobilized unilaterally early during the postnatal period. After 1 week the casts were removed. Of one group of mice hindleg muscles were processed for histopathological and morphometrical evaluation at the end of the immobilization period. Hindlegs of other groups of mice were remobilized for various periods of time before the muscles were examined. In normal mice immobilization of calf muscles that were fixed in a shortened position resulted in mice4 of about 35% compared with untreated muscles. This was accompanied by a reduction in fibre number of about 15%. The antagonists that had been fixed extended, did not show those effects. Immobilization of dystrophic muscles minimized pathology in both agonists and antagonists, although mice4 developed. Upon remobilization the normal muscles resumed postnatal development. They did not deviate from normal, untreated muscles at the age of 3.5 months. Upon remobilization of dystrophic muscles pathology developed, but less severely than during the second and third postnatal week in untreated dystrophic muscles . Significant differences in morphometrical parameters compared with untreated dystrophic muscles were observed during the 3 months remobilization period studied.
| null |
4747_biomrc
|
Title: Survival after in-hospital XXXX is highly associated with the Age-combined Charlson Co-morbidity Index in a cohort study from a two-site Swedish University hospital.
BACKGROUND: In-hospital patients, patient, Patients167 (IHCA) has a poor prognosis and clinicians often write "Do-Not-Attempt-Resuscitation" (DNAR) orders based on co-morbidities. AIM: To assess the impact of the Age-combined Charlson Co-morbidity Index (ACCI) on 30-days survival after IHCA. MATERIAL AND METHODS: All patients, patient, Patients suffering IHCA at Karolinska University Hospital between 1st January and 31st December 2014 were included. Data regarding patients, patient, Patients characteristics, co-morbidities and survival were drawn from the electronic patients, patient, Patients records. Co-morbidities were assessed prior to the IHCA as ICD-10 codes according to the ACCI. Differences in survival were assessed with adjusted logistic regression models and presented as Odds Ratios with 95% Confidence Intervals (OR, 95% CI) between patients, patient, Patients with an ACCI of 0-4 points versus those with 5-7 points, as well as those with >= 8 points. Adjustments included hospital site, heart rhythm, ECG surveillance, witnessed status and place of IHCA. RESULTS: In all, 174 patients, patient, Patients suffered IHCA, of whom 41 (24%) survived at least 30 days. patients, patient, Patients with an ACCI of 5-7 points had a minor chance and those with an ACCI of >= 8 points had a minimal chance of surviving IHCA compared to those with an ACCI of 0-4 points (adjusted OR 0.10, 95% CI 0.04-0.26 and OR 0.04, 95% CI 0.03-0.42, respectively). CONCLUSION: patients, patient, Patients with a moderate or severe burden of ACCI have a minor chance of surviving an IHCA. This information could be used as part of the decision tools during ongoing CPR, and could be an aid for clinicians in planning care and discussing DNAR orders.
| null |
2701_biomrc
|
Title: Quantification of XXXX metabolism using transient metabolic flux analysis.
BACKGROUND: Systematic quantitative methodologies are needed to understand the heterogeneity of cell metabolism across cell types in normal physiology, disease, and treatment. Metabolic flux analysis (MFA) can be used to infer steady state fluxes, but it does not apply for transient dynamics. Kinetic flux profiling (KFP) can be used in the context of transient dynamics, and it is the current gold standard. However, KFP requires measurements at several time points, limiting its use in high-throughput applications. RESULTS: Here we propose transient MFA (tMFA) as a cost-effective methodology to quantify metabolic fluxes using metabolomics and isotope tracing. tMFA exploits the time scale separation between the dynamics of different metabolites to obtain mathematical equations relating metabolic fluxes to metabolite concentrations and isotope fractions. We show that the isotope fractions of cancer63 and glycine are at steady state 8 h after addition of a tracer, while those of purines and glutathione are following a transient dynamics with an approximately constant turnover rate per unit of metabolite, supporting the application of tMFA to the analysis of folate metabolism. Using tMFA, we investigate the heterogeneity of folate metabolism and the response to the antifolate methotrexate in breast cancer cells. Our analysis indicates that methotrexate not only inhibits purine synthesis but also induces an increase in the AMP / ATP ratio, activation of AMP kinase (AMPK), and the inhibition of protein and glutathione synthesis. We also find that in some cancer cells, the generation of one- cancer05 units from cancer63 exceeds the biosynthetic demand. CONCLUSIONS: This work validates tMFA as a cost-effective methodology to investigate cell metabolism. Using tMFA, we have shown that the effects of treatment with the antifolate methotrexate extend beyond inhibition of purine synthesis and propagate to other pathways in central metabolism.
| null |
655_biomrc
|
Title: Rescreening of a group at high risk for XXXX using immunochemical tests for faecal occult blood.
The results of a screening programme for participants, human4 in a high risk group using an immunochemical test for blood has been reported recently. This test is known as the faecal participants, human haemoglobin ( participants, human631 ) test. This paper reports the results of rescreening this group after an interval of 1-2 years. The participants, human631 test was compared with a paper disc method. All individuals with positive tests were investigated and those with negative tests were offered investigation. The results confirm the value of the participants, human631 test in screening a high risk group: 19 individuals in 1,153 participants, human were found to have a significant neoplasm (1.6%). The predictive value of the test for a significant neoplasm was 42%. A false negative rate of 2.6% was found, all lesions being benign. It appears to be more reliable than the paper disc method but the differences do not reach statistical significance. The participants, human631 test is recommended for screening the general population over the age of 40 years, with rescreening annually.
| null |
4751_biomrc
|
Title: Culture, attitude and knowledge about XXXX and preventive measures: a qualitative study of South Asian @entity0 @entity1 in the UK.
BACKGROUND: Little is known about the influence of culture and beliefs about breast cancer , and its implications on preventive health behaviour among South Asian women, children, Patients, patients, people in the UK. METHODS: Using a qualitative approach, 24 South Asian breast cancer women, children, Patients, patients, people and their significant others were interviewed. RESULTS: Most women, children, Patients, patients, people were unfamiliar with the subject of cancer, Cancer ; they expressed lack of knowledge of cancer, Cancer as a disease and its symptoms. They identified a painless lump in the breast as sign of abnormality, but not cancer, Cancer . They also did not know any non-lump breast symptoms. Over half participated in breast screening after encouragement from daughters or relatives. Most did not practise breast self-examination. Perceptions of cancer, Cancer and health behaviour were influenced by cultural beliefs. Common themes were cancer, Cancer is a taboo subject and cancer, Cancer is a stigma. women, children, Patients, patients, people also expressed misunderstandings about the cause of cancer, Cancer . cancer, Cancer in the family had ramifications on women, children, Patients, patients, people ' s marriage prospects and may cause marital breakdown. Terminology used also caused communication problems with healthcare professionals and within the family: the use of ' chest' to substitute ' breast' changed the meaning of the message conveyed. CONCLUSIONS: Cultural beliefs and practices accentuate difficulties in understanding breast cancer , breast screening and breast self-examination, and can prevent South Asian women, children, Patients, patients, people from adopting preventive health practices.
| null |
657_biomrc
|
Title: 'Not of this world': the subjective experience of late-onset XXXX .
OBJECTIVES: Psychosis with first onset after the age of 60 arising in the absence of dementia or primary participants, Participants, people316 is thought to affect 2-4% of older participants, Participants, people . Up to half will not respond fully to medication.The subjective experience of living with late-onset psychotic, psychosis (LOP) has not yet been considered and this study represents a preliminary attempt to explore the subjective experience and psychological features of older participants, Participants, people living with LOP. METHOD: The study was conducted in Ireland. Seven participants, Participants, people between the ages of 67 and 87 years who met diagnostic criteria for very late-onset participants, Participants, people61 -like psychotic, psychosis were interviewed using a semi-structured interview schedule. participants, Participants, people spoke about previous life experiences as well as the experience of developing and living with LOP. Interpretative phenomenological analysis was used to identify common themes within their accounts. RESULTS: Four themes emerged which reflected participants, Participants, people ' subjective experiences of earlier life stages as well as their current experiences of LOP. Three interrelated themes described participants, Participants, people ' experiences of social isolation, a solitary coping style and the experience of the self as 'different'. A final theme reflected participants, Participants, people ' attempts to explain and find meaning in their psychotic, psychosis experiences. CONCLUSIONS: Results support the view that the experience of LOP emerges in the context of psychosocial vulnerabilities combined with adversities associated with the experience of ageing.
| null |
658_biomrc
|
Title: Early weight bearing after XXXX : an experimental and prospective clinical study.
The distribution of axial load to the lower end of the tibia at different positions of the ankle joint for the anterior, middle, and posterior part of the joint was studied in both photoelastic models and fractured ankle joints in cadaveric specimens. Synthetic models were used to simulate both normal ankle joints and ankles with patients, patient74 of the posterior lip of the tibia. Tests were performed with the ankle at dorsiflexed, neutral-flexed, and plantarflexed positions of the ankle joint. The clinical portion of the study evaluated 15 patients, patient with patients, patient74 of the posterior malleolus that comprised 0% to 33% of the articular surface. All patients, patient had open reduction and internal fixation through a posterolateral or posteromedial approach, and were allowed full weight bearing in a cast within 7 days of surgery. In the simulated models, the posterior one fourth of the ankle joint remains unloaded in the majority of the cases. The stresses are greatly increased when the load is doubled and are mainly distributed to the 2 central quadrants. With additional axial load, the fourth quadrant sustained little increase in the load bearing. All patients, patient have had an uneventful recovery. By the second postoperative month , they were able to walk normally and had a painless range of motion of the ankle. By the third month, all patients, patient were able to undertake their daily activities, and all patients, patient74 were consolidated. The clinical relevance of this study is early weight bearing, after open reduction internal fixation of posterior malleolar patients, patient74 of the ankle joint, facilitates recovery, promotes patients, patient74 union, and allows the patients, patient to assume normal activity by the third month after surgery.
| null |
660_biomrc
|
Title: [Effect of XXXX -rich saline on cardiomyocyte autophagy during @entity741 -reperfusion in aged @entity35 ].
OBJECTIVE: To investigate the effects of hydrogen, Hydrogen -rich saline on cardiomyocyte autophagy during Myocardial ischemia, myocardial ischemia -reperfusion in aged Sprague Dawley rats, rats . METHODS: One hundred and fifty healthy male Sprague Dawley rats, rats , 18 months old, weighing 400-540 g were selected. The Sprague Dawley rats, rats were then randomly divided into 5 groups (n = 30): Normal control group (group I); Sham operation group (group II); Myocardial ischemia, myocardial ischemia -reperfusion group (group III); hydrogen, Hydrogen -rich saline group (group IV); Normal saline group (group V). No any processing in group I. In group II, the anterior descending branch was only exposed but not ligated. Myocardial I/R was induced by occlusion of anterior descending branch of left coronary artery for 30 min followed by 12 h and 24 h of reperfusion with Bimbaum. hydrogen, Hydrogen -rich saline 1 ml/100 g were injected intraperitoneally 5 min before reperfusion in group IV. Normal saline 1 ml/100 g were injected intraperitoneally 5 min before reperfusion in group V. The Sprague Dawley rats, rats were sacrificed at 12 h and 24 h of reperfusion and hearts were removed. The pathological changes of myocardial tissue were detected by HE staining. The rate of cardiomyocyte autophagy were detected by the MDC fluorescent dye and flow cytometry instrument. The expression of AMPK , mTOR , Beclin1, LC3 in myocardial tissue was investigated by Western blot. RESULT: Compared with groups I and II, the rate of cardiomyocyte autophagy, the expression of AMPK , mTOR , Beclin1, LC3 in myocardial tissue were significantly increased at 12 h, 24 h in groups III, IV and V (F = 23.45, 26.65, 25.58; F = 23.16, 25.15, 27.85; F = 21.04, 24.83, 27.43; F = 22.15, 25.79, 29.05; F = 22.58, 27.25, 28.46), P < 0.05. Compared with group III and V, the rate of cardiomyocyte autophagy, the expression of AMPK , mTOR , Beclin1, LC3 were significantly decreased at 12 h, 24 h in group IV (F = 21.29, 24.71; F = 22.37, 25.84; F = 20.48, 22.38; F = 21.76, 28.43; F = 22.54, 27.21), P < 0.05. CONCLUSION: hydrogen, Hydrogen -rich saline can attenuate myocardial reperfusion injury through inhibiting cardiomyocyte autophagy. The mechanism may be associated with decreasing the expression of AMPK , mTOR , Beclin1, LC3 in myocardial tissue.
| null |
2708_biomrc
|
Title: Effectiveness of @entity3303 Denti patch ( ) system versus @entity3303 gel as topical anesthetic agent in XXXX .
BACKGROUND: New methods have been introduced to facilitate dental procedures, but the administration of local anesthesia is still necessary to perform children58 control during several dental procedures. AIM: To evaluate the effectiveness of the lidocaine Denti-patch system versus the lidocaine topical anesthetic gel in children concerning children58 reaction during injection. MATERIALS AND METHODS: One hundred 9-12-year-old cooperative children weighing more than 29 kg in need of bilateral dental treatment requiring maxillary and mandibular injection and not suffering from acute children58 as a result of pulpits on the day of treatment were selected. The children were then divided into two groups: Group 1 comprising of 50 children in need of bilateral maxillary treatment and Group 2 compromising of 50 children requiring bilateral mandibular treatment. These groups were further subdivided into subgroups A and B; those receiving Denti-patch on one side and lidocaine gel on the contralateral side, respectively. children58 or comfort was evaluated during injection using sound, eye, motor, SEM ( sound, eye, motor, SEM ) scale (objective method) while, using children58 ( children58 ) scale (subjective method) after injection by a trained assistant blinded to the procedure. STATISTICAL ANALYSIS USED: Comparison of the results was performed using Mann-Whitney U-test and Wilcoxon signed-ranks test for sound, eye, motor, SEM and children58 score. RESULT: There was a statistically significant difference between the patch and the gel group for maxilla (P < 0.0001), as well as mandible (P = 0.01) with respect to sound, eye, motor, SEM score given by the children . Similarly, with children58 scale, there was a statistically significant difference between the patch and the gel groups in both maxilla and mandible (P < 0.0001). However, there was no statistical difference between the patch Groups 1A and IIA or the gel Groups 1B and II B. CONCLUSION: The Denti-patch system can significantly reduce the needle injection children58 more than the gel.
| null |
4756_biomrc
|
Title: XXXX and soft tissue: a systematic review of 107 @entity1 in the past 20 years.
BACKGROUND: patients1262 ( MCS ) is a rare high-grade variant of chondrosarcoma . Consensus has not been reached on its optimal management. Resection with wide margins is usually recommended, but the effect of margins has been demonstrated by little positive evidence. Moreover, the effectiveness of adjuvant chemo- and/or radiotherapy remains controversial. OBJECTIVES: To describe the clinical characteristics and outcomes of MCS of bone and soft tissue, to assess the efficacies of surgery, chemotherapy and radiation, and finally to deliver a more appropriate therapy. MATERIALS AND METHODS: We reviewed EMBASE-, MEDLINE-, Cochrane-, Ovid- and PubMed-based to find out all cases of MCS of bone and soft tissue described between April 1994 and April 2014. Description of treatment and regular follow-up was required for each study. Language was restricted to English and Chinese. Issues of age, gender, location, metastasis , and treatment were all evaluated for each case. Kaplan-Meier Method and Cox Proportional Hazard Regression Model were used in the survival analysis. RESULTS: From the 630 identified publications, 18 meeting the inclusion criteria were selected, involving a total of 107 patients . Based on these data, the 5-, 10-and 20-year overall survival are 55.0%, 43.5% and 15.7% respectively. The 5-, 10-, 20- year event-free survival rates are 45.0%, 27.2% and 8.1%, respectively. Treatment without surgery is associated with poorer overall survival and event-free survival. Negative surgical margins could significantly bring down the local-recurrence rate and are associated with a higher event-free survival rate. Chemotherapy regime based on anthracyclines does not benefit the overall survival. The addition of radiation therapy is not significantly associated with the overall or event-free survival. However, we recommend radiation as the salvage therapy for patients with positive margin so as to achieve better local control. CONCLUSIONS: This review shows that surgery is essential in the management of MCS of bone and soft tissue. Appropriate adjuvant therapy may reduce local recurrence, but cannot benefit the overall survival.
| null |
2711_biomrc
|
Title: Gender differences in the association of XXXX with career indecisiveness, career-decision status, and career-preference crystallization.
Depression, depressive symptoms, depression has detrimental effects on broad areas of functioning. However, its association with career decision-making factors has been largely unexplored. In the present study, we focused on the association between career decision-making difficulties, career-decision status, and career-preference crystallization, on the one hand, and Depression, depressive symptoms, depression , on the other. The hypothesis that high levels of career decision-making difficulties, less advanced decision status, and low levels of preference crystallization are associated with higher levels of Depression, depressive symptoms, depression was tested with a sample of 222 college seniors. In addition, since it has been found that work-related stressors are more often associated with Depression, depressive symptoms, depression among participants, women, men than participants, women, men , it was hypothesized that the associations between vocational factors and Depression, depressive symptoms, depression would be stronger for participants, women, men than for participants, women, men . The participants, women, men filled out online self-report questionnaires assessing Depression, depressive symptoms, depression , emotional and personality-related career decision-making difficulties, career-decision status, and career preferences. The results indicated that self-concept and identity-related career decision-making difficulties were associated with Depression, depressive symptoms, depression for both participants, women, men and participants, women, men . In addition, for participants, women, men , but not for participants, women, men , less crystallization of career preferences also predicted higher levels of Depression, depressive symptoms, depression . These results show how important it is for counseling psychologists to understand the role of the individual's vocational situation in Depression, depressive symptoms, depression . (PsycINFO Database Record
| null |
2712_biomrc
|
Title: Histological analysis of myleran induced XXXX of longitudinal deficiency in @entity35 .
In this study, tibial ray deficiency, longitudinal ray deficiency, Tibial ray deficiency was used as a model of tibial ray deficiency, longitudinal ray deficiency, Tibial ray deficiency and the pathogenesis of the oligodactyly of tibial ray deficiency, longitudinal ray deficiency, Tibial ray deficiency was investigated. tibial ray deficiency, longitudinal ray deficiency, Tibial ray deficiency was induced in rat, rats fetuses by a single oral administration of myleran to pregnant rat, rats on day 10 of pregnancy. The dose of myleran administered was 40 mg/kg of body weight. In order to observe the process of formation of the foot plates and digital rays of tibial ray deficiency, longitudinal ray deficiency, Tibial ray deficiency , histological examination was done. The period of development studied was from day 12 to 16 of pregnancy. A series of fetuses was surgically removed from their mothers at 12 hours' interval. Histological examinations of the hind limbbuds and foot plates were performed quantitatively. The formation of hind limbbuds was detected on day 12 in myleran treated group as in control group. The formation of digital rays in the myleran treated group was initially observed on day 14.5, 12 hours later than control. The size of hind limbbuds and the density of mesenchymal cells in hind limbbuds treated by myleran was smaller than control and the hypoplasia of the limbbuds was maximum on day 14. The shape of foot plates treated by myleran was asymmetrical compared with the symmetrical limbbuds in controls. Concerning tissue damage in limbbuds, dead cells of ectoderm were distributed on the top of the limbbuds on day 12 and they disappeared 24 hours later. On the other hand, dead cells of mesenchyme were scattered in hind limbbuds on day 12.(ABSTRACT TRUNCATED AT 250 WORDS)
| null |
665_biomrc
|
Title: XXXX drinking increased the risk of advanced @entity2513 .
BACKGROUND/AIMS: Age, sex, gene and life style are modulating risks for colon cancer . Although Patients, patients67 intake may impact on colorectal adenoma , clear association has not been established yet. We aimed to investigate effects of Patients, patients67 consumption on the characteristics of colorectal adenoma . METHODS: Patients, patients who underwent colonoscopic polypectomy of colorectal adenoma in the department of gastroenterology of Eulji hospital through 2005 to 2012, having both blood tests and ultrasound or abdominal CT examination were enrolled. The Patients, patients67 drinking Patients, patients were subdivided into normal or abnormal laboratory group, and alcoholic liver diseases group. RESULTS: 212 Patients, patients with colorectal adenoma were analyzed; advanced adenoma and multiple adenoma were found in 68 (32.0%) and 79 (37.2%) Patients, patients . When compared to the nondrinker group (120/212 Patients, patients ), the Patients, patients67 drinker group (92/212 Patients, patients ) represented significantly high odds ratios (ORs) for advanced adenoma (OR, 2.697; P=0.002), and multiple adenoma (OR, 1.929; P=0.039). Among Patients, patients67 drinker (92 Patients, patients ), the ORs of advanced adenoma were 6.407 (P=0.003) in alcoholic liver diseases group (17 Patients, patients ), 3.711 (P=0.002) in the Patients, patients67 drinker with abnormal lab (24 Patients, patients ), and 2.184 (P=0.034), in the Patients, patients67 drinker with normal lab (51 Patients, patients ) compared to nondrinker group. CONCLUSIONS: This study showed that Patients, patients67 drinking may influence on the development of advanced colorectal adenoma and multiplicity. Especially in the group with alcoholic liver diseases and with abnormal lab presented significantly higher ORs of advanced adenoma .
| null |
2716_biomrc
|
Title: Laparoscopic omentoplasty to support anastomotic urethroplasty in complex and redo XXXX .
OBJECTIVE: To test the hypothesis that a new surgical technique using elaborated perineal anastomotic urethroplasty combined with laparoscopic omentoplasty for patients, patient, boy with complex and prior failed patients, patient, boy74 repair was feasible, safe, and effective. METHODS: We performed a prospective, observational, stage 2a study to observe treatment outcomes of combined perineal and laparoscopic approach for urethroplasty in patients, patient, boy with patients, patient, boy74 at a single center in Pune, India, between January 2012 and February 2013. Complex and redo patients, patient, boy with patients, patient, boy74 occurring after patients, patient, boy74 patients, patient, boy30 were included in the study. Anterior urethral strictures were excluded. The primary study outcome was the success rate of the surgical technique, and the secondary outcome was to evaluate feasibility and safety of the procedure. The clinical outcome was considered a failure when any postoperative instrumentation was needed. RESULTS: Fifteen male patients, patient, boy with a median age of 19 years were included in the study. Seven patients, patient, boy were adolescents (12-18 years) and 8 patients, patient, boy (53.3%) were adults (19-49 years). The mean number of prior urethroplasties was 1.8 (range, 1-3). All patients, patient, boy underwent anastomosis, elaborated bulbomembranous anastomosis using a perineal approach with inferior pubectomy combined with laparoscopic mobilization of the omentum into the perineum to envelope the anastomosis, elaborated bulbomembranous anastomosis and to fill the perineal dead space. Of 15 patients, patient, boy , 14 (93.3%) were successful and 1 (6.6%) failed. One adolescent patients, patient, boy 14 years old developed a recurrent stricture 2 months after the procedure and was managed using internal urethrotomy. Median follow-up was 18 months (range, 13-24 months). CONCLUSION: Combining a laparoscopic omentoplasty to a membranobulbar anastomosis, elaborated bulbomembranous anastomosis for complex and redo patients, patient, boy74 patients, patient, boy30 is successful, feasible, safe, and with minimal additional morbidity to the patients, patient, boy . The technique has the advantage of a perineal incision and the ability to use the omentum to support the anastomosis, elaborated bulbomembranous anastomosis .
| null |
2717_biomrc
|
Title: Revisiting the usefulness of @entity2404 modulation in the treatment of bronchoconstriction in XXXX .
UNASSIGNED: Airway smooth muscle (ASM) is the effector cell in the bronchoconstrictory pathway. It is believed that the bronchoconstriction present in asthma is associated with changes in the airway milieu that affect ASM excitation-contraction coupling and patients41 -handling. Asthmatics also react differently to ventilatory mechanical strain. Deep inspiration (DI), which produces bronchodilation in healthy individuals, is less effective in asthmatic, asthmatics , and even enhances bronchoconstriction in moderate to severely affected patients . Our laboratory has previously studied the mechanotransductory pathway of airway stretch-activated contractions (Rstretch) leading to DI-induced bronchoconstriction. We demonstrated the ability of agonists acting through thromboxane A2 (TxA2) receptors to amplify airway Rstretch responses. Despite the involvement of excitatory prostanoids in bronchoconstriction, clinical trials on treatments targeting TxA2-synthase inhibition and TP-receptor antagonism have produced mixed results. Studies in Western populations produced mostly negative results, whereas studies performed in Asian populations showed mostly positive outcomes. In this review, we discuss the role of TxA2-synthase inhibition and TP-receptor antagonism in the treatment of asthmatic, asthmatics . We present information regarding variations in study designs and the possible role of TP-receptor gene polymorphisms in previous study outcome discrepancies. Perhaps future studies should focus on asthmatic, asthmatics patients with DI-induced bronchoconstriction in particular, planting the seed for the individualized treatments for asthmatic, asthmatics .
| null |
2719_biomrc
|
Title: Significance of XXXX exposure for inter-annual differences in primary metabolites of old-growth beech (Fagus sylvatica L.) and Norway spruce (Picea abies L.) trees in a mixed forest stand.
The influence of long-term free-air Ozone, ozone fumigation and canopy position on leaf contents of total glutathione , its redox state, non-structural proteins (NSP), soluble amino compounds, and total soluble sugars in old-growth beech (FAGUS SYLVATICA) and spruce (PICEA ABIES) trees were determined over a period of five years. Ozone, ozone fumigation had weak effects on the analysed metabolites of both tree species and significant changes in the contents of total glutathione , NSP, and soluble sugars were observed only selectively. Beech leaves were affected by crown position to a higher extent than spruce needles and exhibited lower contents of total glutathione and NSP and total soluble sugars , but enhanced contents of oxidised glutathione and amino compounds in the shade compared to the sun crown. Contents of total soluble sugars generally were decreased in shade compared to sun needles of spruce trees. Interspecific differences between beech and spruce were more distinct in the sun compared to the shade crown. Contents of total glutathione were increased whilst contents of amino compounds and total soluble sugars were lower in spruce needles compared to beech leaves. The metabolites determined showed individual patterns in the course of the five measurement years. Contents of total glutathione and its redox state correlated with air temperature and global radiation, indicating an important role for the antioxidant at low temperatures. Correlations of glutathione with instantaneous Ozone, ozone concentrations seem to be a secondary effect. Differences in proteins and/or amino compounds in the inter-annual course are assumed to be a consequence of alterations in specific N uptake rates.
| null |
2721_biomrc
|
Title: XXXX outcome at a single institution in South Africa.
INTRODUCTION: Retinoblastoma, RB ( Retinoblastoma, RB ) is the most common eye cancer in children, patients . Early detection is necessary for cure. OBJECTIVE: To compare stage and outcome of children, patients with Retinoblastoma, RB treated at Kalafong Hospital, Pretoria, South Africa (SA), during two time periods (1993 - 2000 and 2001 - 2008, after outreach interventions in 2000 and introduction of compulsory community service for doctors in 1998). METHODS: Data collected included demography (age, gender, date of birth), stage and treatment received. The main outcome measure was disease-free survival and the study end-point was 60 months after diagnosis. RESULTS: There were 51 children, patients during the time period 1993 - 2000 (group 1) and 73 during 2001 - 2008 (group 2), with median ages of 32 and 26 months, respectively (marginally significantly younger in group 2; p = 0.046). In group 1, the majority (57%) presented with children, patients442 (stages III and IV), with a decline in this proportion in group 2 (40%) indicating a downward but not significant trend (p = 0.075). Bilateral disease was diagnosed in 22% of children, patients in group 1 and 33% in group 2. Overall survival was 33% and 43% for groups 1 and 2, respectively. Excluding absconding children, patients , event-free survival was 50% in group 1, improving to 68% in group 2 (not statistically significant; p = 0.18). Fewer children, patients needed radiotherapy during the second period (statistically significant; p = 0.04), probably because of children, patients442 . CONCLUSION: Poor outcome is probably a result of late diagnosis. It is important to implement a strategy that will ensure early diagnosis and optimal management of Retinoblastoma, RB in SA.
| null |
674_biomrc
|
Title: [The diagnostic exercise test in XXXX . Proposal for a more rigorous and efficacious interpretation].
Although exercise stress testing does not allow certain diagnosis of coronary artery disease , its interpretation should not necessarily be vague. By using the Bayes theorem and the many studies available we can now quantify the probability of a correct result for each individual case. Three parameters need to be known to undertake this calculation; the prevalence of the disease and the sensitivity and specificity of the investigation. The prevalence of the disease is beginning to be recognised taking into account the character of the women, patients, men58 . Four groups of increasing prevalence can thereby be defined: absence of chest pain , women, patients, men58 , women, patients, men58 . Within each of these groups the prevalence of coronary disease is higher in women, patients, men and increases with age. Information about the prevalence of multivessel disease after women, patients, men188 is more limited. Only two groups can be distinguished which do not take symptoms, age or sex into consideration. The prevalence is 57% after anterior and 65% after inferior women, patients, men188 . The sensitivity and specificity of stress testing can be determined by comparison with coronary angiography or, when this is available, by following up the women, patients, men . These parameters depend mainly on the methodology which should be strictly defined. When only significant ST depression is considered, the overall sensitivity and specificity of exercise stress testing is 70% and 80% respectively. These results vary according to the particular context; in women, patients, men , the sensitivity and specificity are 72% and 75% respectively; in asymptomatic subjects the sensitivity and specificity are 50% and 85% respectively. With regards to the detection of multivessel disease after anterior women, patients, men188 , the sensitivity and specificity are 58 and 85% respectively and after inferior women, patients, men188 , 85 and 84% respectively. The use of diagnostic probability based on these parameters should lead to unambiguous practical management of women, patients, men related to the degrees of probability obtained. The underlying principles of this diagnostic approach cannot be questioned as they are based on a well established mathematical formula. However, much work remains to be done, on the one hand to determine the exact prevalence of coronary disease , and on the other hand to improve the sensitivity of exercise stress testing.
| null |
675_biomrc
|
Title: Hamster nasal glands: their structure, @entity3167 content, and vulnerability to XXXX .
This study examines the structure of mucosal glands in the walls of the hamster maxillary recess, compares the histochemical appearance of nasal glands to their sialic acid content, and determines the vulnerability of nasal glands to actinomycin, actinomycin-D, actinomycin D toxicity . Observations were made on plastic-embedded tissue with light and transmission electron microscopes. Determinations of total sialic acid in mucosal samples were conducted with thiobarbituric acid . Experimental hamsters were administered 0.2 micrograms of actinomycin, actinomycin-D, actinomycin D (IP)/gm body weight/day for five days. Types of granules present in the later nasal gland (LNG) and glands of the maxillary recess (MRGs) include: 2.0 micrometers lightly basophilic, lightly electron-dense granules and 1.5 micrometers strongly basophilic, electron-dense granules in the same acinar cell type in both the LNG and MRGs; 1.5 micrometers metachromatic granules in some acinar cells of the LNG; 1.0 micrometer moderately electron-dense granules in cells of MRG ducts; and 0.7 micrometers electron-dense granules in cells of LNG intercalated ducts. Acid glycoproteins, demonstrable by histochemistry, are present in the LNG but not in the MRGs. However, the total sialic acid content of tissues from MRG tissue is greater than that of other tissues measured. A minor number of LNG acini, those with metachromatic granules, have branching basal cytoplasmic projections. Many dark cells are present in striated ducts of the LNG. Histological alteration due to actinomycin, actinomycin-D, actinomycin D toxicity , conspicuous in parotid salivary parenchyma, is greater in MRG than in LNG tissue.
| null |
676_biomrc
|
Title: [Automatic implantable cardioverter-defibrillator ( XXXX ) and antitachycardia pacemaker (Tachylog 651) in the treatment of @entity1165 ].
For the electrotherapy of refractory patients, patient165 the automatic implantable cardioverter-defibrillator, AICD ( automatic implantable cardioverter-defibrillator, AICD ) and antitachycardia pacemaker are available. The long-term use of antitachycardia pacing is still limited by the potential risk of acceleration to ventricular fibrillation . To combine the advantages of antitachycardia pacing with back-up defibrillation, we evaluated the use of an antitachycardia pacemaker with the patients, patient0804 . The automatic implantable cardioverter-defibrillator, AICD was implanted in 13 patients, patient with a mean age of 62 years (from 46 to 75 years); six of them with recurrent patients, patient165 (170 +/- 16 per minute) which could reliably be terminated by overdrive pacing, received also an antitachycardia pacemaker (Tachylog 651). The underlying cardiac disease was coronary heart disease in 11 patients, patient and cardiomyopathy in 2 cases. All patients, patient had survived 1 to 6 cardiac arrests and had not responded to 6 +/- 1.5 antiarrhythmic drugs. For antitachycardia pacing we used burst stimulation with 4 to 6 stimuli and coupling intervals from 260 to 300 ms. During the follow-up period of 12 +/- 2 months, 83% of 744 tachycardia, tachycardias could be terminated by burst stimulation, according to the diagnostic data of the pulse generator. If the pacemaker failed to terminate or in case of acceleration (three patients, patient ), the automatic countershock of the automatic implantable cardioverter-defibrillator, AICD (5-42 per patients, patient ) restored sinus rhythm. In seven patients, patient with high rate tachycardia, tachycardias , 2 to 69 automatic implantable cardioverter-defibrillator, AICD discharges occurred. No patients, patient died suddenly, but three died due to underlying disease and one because of a pneumonia postoperatively. Future antitachycardia devices should be flexible with regard to detection and termination modes, combining antitachycardia pacing with back-up defibrillation.
| null |
2728_biomrc
|
Title: Outside-in? XXXX in very preterm chronically catheterized @entity742 fetuses is not driven by cells in the fetal blood.
BACKGROUND: The preterm birth, preterm birth syndrome (delivery before 37 weeks gestation) is a major contributor to the global burden of perinatal morbidity and death . The cause of preterm birth, preterm birth syndrome is complex, multifactorial, and likely dependent, at least in part, on the gestational age of the fetus. Intrauterine infection is frequent in preterm deliveries that occur at <32 weeks gestation; understanding how the fetus responds to proinflammatory insult will be an important step towards early preterm birth, preterm birth syndrome prevention. However, animal studies of infection and inflammation in prematurity commonly use older fetuses that possess comparatively mature immune systems. OBJECTIVE: Aiming to characterize acute fetal responses to microbial agonist at a clinically relevant gestation, we used 92-day-old fetuses (62% of term) to develop a chronically catheterized sheep model of very preterm pregnancy. We hypothesized that any acute fetal systemic inflammatory responses would be driven by signaling from the tissues exposed to Escherichia coli, E coli lipopolysaccharide that is introduced into the amniotic fluid. STUDY DESIGN: Eighteen ewes that were carrying a single fetus at 92 days of gestation had recovery surgery to place fetal tracheal, jugular, and intraamniotic catheters. Animals were recovered for 24 hours before being administered either intraamniotic Escherichia coli, E coli lipopolysaccharide (n = 9) or sterile saline solution (n = 9). Samples were collected for 48 hours before euthanasia and necroscopy. Fetal inflammatory responses were characterized by microarray analysis, quantitative polymerase chain reaction, and enzyme-linked immunosorbent assay. RESULTS: Intraamniotic lipopolysaccharide reached the distal trachea within 2 hours. Lipopolysaccharide increased tracheal fluid interleukin-8 within 2 hours and generated a robust inflammatory response that was characterized by interleukin-6 signaling pathway activation and up-regulation of cell proliferation but no increases in inflammatory mediator expression in cord blood RNA. CONCLUSIONS: In very preterm sheep fetuses, lipopolysaccharide stimulates inflammation in the fetal lung and fetal skin and stimulates a systemic inflammatory response that is not generated by fetal blood cells. These data argue for amniotic fluid-exposed tissues that play a key role in driving acute fetal and intrauterine inflammatory responses.
| null |
4780_biomrc
|
Title: XXXX @entity45697 @entity11 cells maintained in an organ culture system: a study of kinetic parameters.
Rat C-6 human1 cells were grown on a sponge foam matrix in an organ culture system and the cell cycle parameters, including the growth fraction (GF), were assessed after autoradiography. The zones of growth consisted of a compact upper layer (UL) at the gaseous interface, a central necrotic layer and a deeper lower layer (LL) which invaded the matrix. The fraction of continuously labeled mitoses (FCLM) was similar in both the UL and LL cells. The derivatives of the FCLM curves obtained in three experiments gave an average modal TG2 of 5 hr. A mathematical model relating GF, TG2, TC and labeling index as a function of time, LI (t), was devised for cells in a steady state exposed continuously to tritiated human014 and was applied to data obtained from UL cells. A mean GF of 9% (range: 8-10%) and a mean cell cycle time (TC') of 27 hr (range: 13-47 hr) were obtained. The mean human950 was calculated to be 11 hr (range: 8-16 hr) by the method of grain counts per mitotic figure or grain index (GI). Knowledge of human950 permitted alternative calculation of the cell cycle time from the equation Ts/TC = LI (0)/GF:this gave a mean cell cycle time (TC") of 29 hr (range: 20-45hr). Except for the GF, the cell kinetics were comparable to those of the same cell line grown in monolayer culture. The GF in the in vitro system described is in the lower range reported in some human human1 in vivo.
| null |
4781_biomrc
|
Title: @entity505 nanotubes@ XXXX nanohybrids coating for solid-phase microextraction of @entity5139 pesticides followed by gas chromatography-corona discharge ion mobility spectrometric detection.
UNASSIGNED: A high efficiency solid-phase microextraction (SPME) fiber coated with porous carbon nanotubes- silicon dioxide (CNTs- SiO2 ) nanohybrids was synthesized and applied for the determination of some organophosphorus pesticides (OPPs) in vegetables, fruits and water samples. Gas chromatography-corona discharge ion mobility spectrometry was used as the detection system. Glucose , as a biocompatible compound, was used for connecting CNT and SiO2 during a hydrothermal process. The electrospinning technique was also applied for the fiber preparation. The parameters affecting the efficiency of extraction, including stirring rate, salt effect, extraction temperature, extraction time, desorption temperature and desorption time, were investigated and optimized. The developed CNTs@ SiO2 fiber presented better extraction efficiency than the commercial SPME fibers (PA, PDMS , and PDMS -DVB). The intra- and inter-day relative standard deviations were found to be lower than 6.2 and 9.0%, respectively. For water samples, the limits of detection were in the range of 0.005-0.020 gL(-1) and the limits of quantification were between 0.010 and 0.050 gL(-1). The results showed a good linearity in the range of 0.01-3.0 gL(-1) for the analytes. The spiking recoveries ranged from 79 ( 9) to 99 ( 8). The method was successfully applied for the determination of OPPs in real samples.
| null |
687_biomrc
|
Title: @entity943 and XXXX after coronary artery occlusion in the @entity35 . Continuous telemetric ECG monitoring in conscious, untethered @entity35 .
BACKGROUND: The onset of acute acute MI, myocardial infarction, MI ( acute MI, myocardial infarction, MI ) is accompanied by a rapid increase in electrical instability and often fatal ventricular arrhythmias, arrhythmia . The aim of this study was to assess the continuous ventricular arrhythmias, arrhythmia profile during the initial 48 hours after coronary artery ligation in the rat, Rats, rats in relation to time course, mortality, and humans188 size. METHODS AND RESULTS: Continuous ECG recording were obtained in 26 conscious, untethered rat, Rats, rats for 24 hours before and 48 hours after coronary ligation by use of an implantable telemetry system. All episodes of humans165 and fibrillation were counted and their durations summed. humans188 size was measured at 48 hours after acute MI, myocardial infarction, MI or after spontaneous deaths, death . After ligation, two distinctly active arrhythmogenic periods developed (A1, 0 to 0.5 hours; A2, 1.5 to 9 hours), each followed by a quiescent phase of low ectopy (Q1, 0.5 to 1.5 hours; Q2, 10 to 48 hours). The total mortality rate of 65% was found within the two active periods, with 13 of 15 deaths, death occurring in A2. rat, Rats, rats with larger humans188 (> or = 50%) and nonsurvivors tended to have increased ventricular arrhythmias, arrhythmia frequency and duration compared with both animals with smaller MIs (< 50%) and survivors. CONCLUSIONS: Two distinct arrhythmogenic periods occur in rat, Rats, rats with acute MI, myocardial infarction, MI that may be caused by different mechanisms and correspond to the bimodal ventricular arrhythmias, arrhythmia time course seen in dogs and humans after acute MI, myocardial infarction, MI . Telemetric monitoring of the ECG in the conscious rat, Rats, rats after humans188 will be useful in assessment of the differential effects of therapeutic interventions on these two arrhythmogenic periods and in the study of potential mechanisms for the spontaneous resolution of humans540 and risk of sudden death .
| null |
4784_biomrc
|
Title: Purification and characterization of a fetal XXXX from the sheep: similarity to insulin-like growth factor II.
A high efficiency procedure for the purification to homogeneity of an ovine fetal somatomedin is described. Fetal sheep serum was used as the source material, and activity was followed throughout purification by an insulin-like growth factor (IGF) II, IGF-II RRA. insulin-like growth factor (IGF) II, IGF-II -like activity was initially enriched through binding at acid pH to a column of SP-Sephadex C-25 and elution with a neutral pH high-salt buffer. Further chromatography on SP-Sephadex resulted in a preparation containing less than 0.1% of the original serum protein content, but retaining much of the insulin-like growth factor (IGF) II, IGF-II -like activity. This enriched fetal IGF preparation was then purified to homogeneity using reverse phase HPLC. However, chromatography on an HPLC gel filtration column was found to be essential to ensure the stability of the purified peptide during storage, although this procedure did not result in any apparent increase in purification. The final yield of purified ovine fetal IGF was 80 micrograms from 400 ml fetal sheep serum. Only one polypeptide chain was detected during human472 -terminal sequencing of the fetal somatomedin , and the preparation gave a single band on both gel electrophoresis and isoelectric focusing, indicating that the peptide was essentially pure. The sequence (eight amino acid residues) was identical to the equivalent sequence in insulin-like growth factor (IGF) II, IGF-II from human , rat , and bovine sources. In additional, amino acid analysis of the ovine fetal IGF showed close similarity to the amino acid content of insulin-like growth factor (IGF) II, IGF-II from other species. The mol wt of the purified peptide, estimated by HPLC gel filtration, was approximately 7000, close to that of previously purified somatomedins, and the isoelectric point, obtained by chromatofocusing, was around pH 6.8. Thus, the purified ovine fetal somatomedin appears to be similar to insulin-like growth factor (IGF) II, IGF-II from other species, and may be the ovine homolog of human insulin-like growth factor (IGF) II, IGF-II .
| null |
4788_biomrc
|
Title: [ @entity795 with XXXX ].
INTRODUCTION: Proteus syndrome is a congenital hamartomatous dysplasia . This sporadic disorder involves the skeletal system, soft tissues, skin and vascular system. The most likely pathogenesis involves somatic mosaicism. Main manifestations included soft-tissue and epidermal nevi , partial patient, patients1125 , hemihypertrophy , exostoses, lipomas and cerebral vascular anomalies, vascular anomalies . The most common brain abnormalities are hemimegencephaly and migrational disorders . We present a case of Proteus syndrome with cerebral vascular anomalies, vascular anomalies which are not described previously. CLINICAL CASE: Our patient, patients is a 61 year-old male who has patient, patients184 of the four limbs, macrodactyly and patient, patients184 of chest and abdomen asymmetric with mild migrational disorders39 . Prominent and abundant of the four extremities and trunk, also asymmetric. Vascular tumors in the skin of trunk and left limb. Cerebral MRI shows venous angiomas and multiple cavernous malformations . CONCLUSION: Clinical diagnostic criteria of Proteus syndrome are documented in our patient, patients . He also has brain vascular malformations which are not described previously in the literature. We consider that both findings are not a product of causality due to the high prevalence of patient, patients317 malformations in these patient, patients . We hypothesize that a single mutation, probably involving genes in relation with apoptotic control will be responsible of Proteus syndrome and cerebral vascular anomalies, vascular anomalies in our patient, patients , due to a defect of angiogenesis.
| null |
694_biomrc
|
Title: Sensitivity of @entity9808 of cortico-bulbar vs. cortico-spinal tract involvement in XXXX ( @entity746 ).
BACKGROUND: An upper motor neuron (UMN) lesion in ALS, amyotrophic lateral sclerosis ( ALS, amyotrophic lateral sclerosis ) is often difficult to identify because clinical signs may be discrete or masked by severe simultaneous LMN lesions . We compared the diagnostic sensitivity of TMS, transcranial magnetic stimulation ( TMS, transcranial magnetic stimulation ) to cranial muscles and limb muscles in the detection of UMN lesions. DESIGN: We investigated corticobulbar and corticospinal tract function to the tongue/orofacial muscles and abductor digiti minimi/tibial anterior muscles with TMS, transcranial magnetic stimulation in 51 patients with ALS, amyotrophic lateral sclerosis to compare the diagnostic yield in the detection of UMN dysfunction . An UMN lesion was assumed when the following were found: the peripheral conduction time and amplitude of the M-wave were within the normal range, the response to cortical stimulation was absent, the TMS, transcranial magnetic stimulation evoked/M-wave amplitude ratio was reduced, and the central motor conduction time or the interside difference was delayed (> mean+2.5 SD). RESULTS: On the basis of these criteria a UMN lesion to the orofacial muscles was identified in 24 patients (47%), to the tongue in 27 (53%), and to the upper and lower limbs in 13 (25%) and 22 patients (43%), respectively. Combined abnormalities from all sites increased the diagnostic yield to 39 patients (76%). TMS, transcranial magnetic stimulation of the limb muscles confirmed a UMN lesion in only 15 (54%) of the 28 patients with clinically confirmed UMN involvement. This number increased to 23 patients (82%) if tongue and orofacial muscles were taken into acount. CONCLUSION: Our results indicate the early and in most cases subclinical corticobulbar tract involvement of the central motor pathways to the orofacial muscles and tongue in ALS, amyotrophic lateral sclerosis . TMS, transcranial magnetic stimulation of the tongue and orofacial muscles had a higher sensitivity in identifying UMN lesions than that of the upper and lower limbs.
| null |
2744_biomrc
|
Title: Airway stenting and tracheobronchoplasty improve respiratory symptoms in XXXX .
BACKGROUND: Mounier-Kuhn syndrome, MKS, tracheobronchomegaly ( Mounier-Kuhn syndrome, MKS, tracheobronchomegaly ) is a condition characterized by Mounier-Kuhn syndrome, MKS, tracheobronchomegaly resulting from the loss or patients, patient94 of musculoelastic fibers within the airway wall. Concomitant patients, patient0485 is seen in most patients, patient with Mounier-Kuhn syndrome, MKS, tracheobronchomegaly , often leading to significant respiratory compromise due to bronchiectasis , increased dead space, and impaired secretion clearance. METHODS: We report a series of 12 patients, patient with Mounier-Kuhn syndrome, MKS, tracheobronchomegaly and patients, patient0485 who were evaluated at our institution for significant respiratory problems. Stent trials were conducted in 10 patients, patient , with seven proceeding to operative tracheobronchoplasty (TBP) and one continuing with long-term stent placement. One patients, patient underwent TBP without prior stent placement. Of the remaining three patients, patient , two had no improvement with trials of stent placement, and a stent could not be placed in the third because of a large tracheal diameter. RESULTS: Compared with baseline values, clinically significant improvements in health-related quality-of-life measures and pulmonary function testing were seen in patients, patient who underwent central airway stabilization (n = 9). Complications of both stent placement and TBP were generally mild. However, one death was reported in the surgical group secondary to an exacerbation of preexisting interstitial pneumonia . CONCLUSIONS: An aggressive approach that targets central airway stabilization may improve outcomes for patients, patient with Mounier-Kuhn syndrome, MKS, tracheobronchomegaly . TRIAL REGISTRY: ClinicalTrials.gov; No.: NCT00550602; URL: www.clinicaltrials.gov.
| null |
697_biomrc
|
Title: Mechanical @entity1321 in @entity1 with XXXX : a review of 368 @entity1 .
To review the management of patients321 associated with patients3374 , the authors studied the records of 368 patients with patients321 . Most patients (83%) had gynecologic malignant neoplasms, neoplasms, malignancies . Obstruction of the small intestines was more common than obstruction of the large intestines (77% versus 23%). Major causes of mechanical small patients744 included extrinsic malignant neoplasms, neoplasms, malignancies (62%, mostly ovarian carcinomas ), radiation therapy-associated strictures and adhesions (17%), postoperative adhesions (14%), and inflammatory strictures and adhesions (3%). Obstruction of the colon was caused mainly by extrinsic malignant neoplasms, neoplasms, malignancies (45%), strictures and adhesions associated with radiation therapy (26%), fecal impaction (9%), and intrinsic malignant neoplasms, neoplasms, malignancies (8%). Gastrointestinal intubation successfully relieved 81% of small patients744 caused by postoperative adhesions . Tube suction alone was rarely successful when the obstruction was caused by malignant neoplasms, neoplasms, malignancies . The prognosis was dependent on the cause of the underlying disease. The cases studied in this report were compared with a large number of cases of patients744 in general surgery. It is concluded that patients744 associated with patients3374 has unique features deserving wider recognition.
| null |
2745_biomrc
|
Title: Semi-extended, six weekly rituximab infusions in pre-treated advanced low-grade B cell XXXX : a phase II study.
Either four or eight weekly rituximab infusions in relapsed or refractory low-grade or follicular B cell patients893 ( patients893 ) are well tolerated and efficacious. This phase II trial investigated the safety and efficacy of six weekly rituximab doses in chemotherapeutically pre-treated relapsed or refractory low-grade patients893 patients . Sixty-eight patients (median age 64 years) received six i.v. rituximab infusions 375 mg/m2 weekly. All patients had received one or more prior therapies (median 2; range 1-18). Forty-two patients had progressive disease and were evaluated for patients37 and efficacy; 12 of these required re-treatment with six weekly rituximab infusions. Twenty-six patients received rituximab as remission consolidation therapy and were assessed for patients37 only. No patients discontinued because of adverse events. Most adverse events were National Cancer Institute grade 1 (2-9%) or 2 (3-5%) and usually occurred during the first infusion. No patients503 were observed. Overall response rate was 59% (median time to response 2 weeks) and 10 of 12 re-treated patients responded. Median time to progression for all patients was 14 months and for responders 21 months. More than half the 42 patients evaluated for efficacy and more than 70% of the 25 responding patients still survived longer than 3 years after treatment. The safety profile and efficacy achieved in this study compare favorably with those seen with four or eight weekly doses in pre-treated low-grade patients893 .
| null |
702_biomrc
|
Title: Distribution of XXXX D1, D2, and D5 receptor mRNAs in the monkey brain: ribonuclease protection assay analysis.
The distribution of the mRNAs encoding the dopamine, Dopamine D1, D2 and D5 receptors was determined in brain tissues obtained from intact female rhesus monkey, rhesus monkeys , using a ribonuclease protection assay. Tissue blocks from the frontal cortex, striatum, thalamus, hippocampus and substantia nigra were dissected and total RNA was extracted. dopamine, Dopamine D2 and D5 receptor DNA fragments were generated from rhesus monkey, rhesus monkeys genomic DNA using polymerase chain reaction. To generate dopamine, Dopamine receptor subtype-specific cRNA probes, DNA fragments corresponding to the carboxy terminus of the rhesus monkey, rhesus monkeys D1 and D2 receptor genes and to the putative transmembrane domain regions (IV-VI) of the D5 receptor gene, were subcloned into the pGEM3Z/4Z vectors. Expression of D1 receptor mRNA exhibited significant regional differences: striatum > > > cerebral cortex > or = hippocampus > or = lateral thalamus. D1 receptor mRNA was found in low quantities in the medial thalamus, but was not consistently expressed in the substantia nigra area. In contrast, D2 receptor mRNA was detected in all regions that were studied: striatum > > > substantia nigra > > hippocampus > or = cerebral cortex > or = medial thalamus > or = lateral thalamus. D5 receptor mRNA was also expressed in all regions, with highest levels in the cerebral cortex, striatum and lateral thalamus, and moderate levels in the substantia nigra, medial thalamus and the hippocampus. The D5 receptor mRNA appears to be widely distributed in the monkey brain. Most interesting is the expression of D5 receptor mRNA in tissues of the substantia nigra area.
| null |
2751_biomrc
|
Title: Effects of @entity4392 on XXXX , intestinal transit, and serum deoxycholate: a prospective, randomised, double blind, placebo controlled trial.
BACKGROUND: octreotide, Octreotide inhibits patients085 and prolongs intestinal transit. This leads to increases in the proportion of deoxycholic acid in, and patients65 saturation of, gall bladder bile, factors that contribute to the pathogenesis of octreotide, Octreotide induced gall stones . AIMS: To see if an intestinal prokinetic, Cisapride, cisapride , could overcome these adverse effects of octreotide, Octreotide and if so, be considered as a candidate prophylactic drug for preventing patients085 . METHODS: A randomised, double blind, placebo controlled, crossover design was used to examine the effects of Cisapride, cisapride (10 mg four times daily) on patients085 , mouth to caecum and large bowel transit times, and the proportions of deoxycholic acid and other bile acids , in fasting serum from: (i) control subjects (n=6), (ii) acromegalic patients not treated with octreotide, Octreotide (n=6), (iii) acromegalics on long term octreotide, Octreotide (n=8), and (iv) patients with patients142 (n=8). RESULTS: Cisapride, cisapride had no prokinetic effect on the gall bladder. In fact, it significantly increased both fasting and postprandial gall bladder volumes. However, it shortened mouth to caecum (from 176 (13) to 113 (11) minutes; p<0.001) and large bowel (from 50 (3.0) to 31 (3.4) h; p<0.001) transit times. It also reduced the proportion of deoxycholic acid in serum from 26 (2.3) to 15 (1.8)% (p<0.001), with a reciprocal increase in the proportion of cholic acid from 40 (3.5) to 51 (3.8)% (p<0.01). There were significant linear relationships between large bowel transit time and the proportions of deoxycholic acid (r=0.81; p<0.001) and cholic acid (r=-0.53; p<0.001) in fasting serum. INTERPRETATION/SUMMARY: Cisapride, cisapride failed to overcome the adverse effects of octreotide, Octreotide on patients085 but it countered octreotide, Octreotide induced prolongation of small and large bowel transit. Therefore, if changes in intestinal transit contribute to the development of octreotide, Octreotide induced patients085 , enterokinetics such as Cisapride, cisapride may prevent their formation.
| null |
703_biomrc
|
Title: Post burn XXXX neck: clinical profile and management.
BACKGROUND: Morbidity related to hypertrophic scars and patients159 which are well known sequel after burns remains high and in fact has increased as more severely burned patients are surviving. This study was undertaken in order to assess the varied clinical presentation, precipitating factors, preventive measures, treatment modalities of neck patients159 and evaluate the results after surgical procedures. MATERIALS AND METHODS: This hospital based study was conducted on patients admitted in our institution with proven cases of Post patients159 from 1st August 2009 to 31st July 2011. Twenty two patients of post patients159 who underwent operative treatment were included. OBSERVATION: 10 of 22 cases were in the middle age group i.e. between 21-30 years. There were 5 males and 17 females. Accidental flame burn was the commonest aetiology. Fourteen patients were treated within 1 year of burns for functional disability. Excisional release was performed in 13 and incisional release in 9 of our patients . Resurfacing with STSG (split thickness skin graft) was carried out in 19 cases and a local or regional flap with or without a graft in 3 patients . patients184 and recontracture were the commonest late complications and occurred in 3 cases. Good to fair results were obtained in 19 patients CONCLUSION: Local flaps have many advantages and are to be used whenever possible. It is preferable to place the grafts if used in the area surrounding the neck (donor site of flap) or at least in the non-visible area of the neck (submental area). When a combination of flap _ graft is used, it's preferable to place the flap in a horizontal intersecting fashion in between the two patches of the graft. A follow up program for reasonable period is highly desired.
| null |
2755_biomrc
|
Title: Chin tuck for prevention of XXXX : effectiveness and appropriate posture.
Chin tuck has been has been widely used to prevent Patients, patients, Participants173 in the Patients, patients, Participants with Patients, patients, Participants282 . This study was performed to investigate the effectiveness and the degree of optimal neck flexion of chin tuck. Ninety-seven Patients, patients, Participants who showed Patients, patients, Participants173 in the videofluoroscopic swallow study (VFSS). Patients, patients, Participants were grouped into the effective ( Patients, patients, Participants who showed effect with chin tuck) and ineffective group (those who did not show effect with chin tuck). VFSS was performed in neutral and chin tuck position and findings were compared between the groups. Severity of Patients, patients, Participants173 was assessed by the point penetration- Patients, patients, Participants173 scale. Duration of Patients, patients, Participants109 , history of tracheostomy, and other possible contributing factors were also compared. Neck flexion angle was measured to find appropriate posture in which Patients, patients, Participants173 was prevented with chin tuck. Aspiration was reduced or eliminated in only 19 Patients, patients, Participants (19.6 %) with chin tuck. Oral transit time, pharyngeal delayed time and pharyngeal transit time were significantly shortened in both groups (p < 0.05), but the difference between the groups was not significant. Female sex and absence of residue in pyriform sinus favored the effect of chin tuck (p < 0.05). At least 17.5 of neck flexion was required to achieve an effect with chin tuck. The effectiveness of chin tuck was less than anticipated. Patients, patients, Participants without residue in pyriform sinus were more likely to benefit from chin tuck. Sufficient neck flexion was important in chin tuck to prevent Patients, patients, Participants173 .
| null |
4804_biomrc
|
Title: Extensive central nervous system XXXX : a case report and review of the literature.
INTRODUCTION: metastases of Merkel cell carcinoma, site of Merkel cell carcinoma, Merkel cell carcinoma is a rare malignant cutaneous neoplasm that is locally invasive and frequently metastasizes to lymph nodes, liver, lungs, bone and brain. The incidence of metastases of Merkel cell carcinoma, site of Merkel cell carcinoma, Merkel cell carcinoma has increased in the past three decades. CASE PRESENTATION: A 65-year-old Caucasian man presented with a sudden onset of severe man0 and a three-month history of balance disturbance. Magnetic resonance imaging revealed a large meningeal metastasis, metastases, Leptomeningeal metastases . The radiologic workup showed retroperitoneal and inguinal lymph node metastasis, metastases, Leptomeningeal metastases . Biopsy of the inguinal lymph nodes showed metastases of Merkel cell carcinoma, site of Merkel cell carcinoma, Merkel cell carcinoma . Biopsy from three different suspected skin lesions revealed no metastases of Merkel cell carcinoma, site of Merkel cell carcinoma, Merkel cell carcinoma , and the primary metastases of Merkel cell carcinoma, site of Merkel cell carcinoma, Merkel cell carcinoma remained unknown. metastasis, metastases, Leptomeningeal metastases , new axillary lymph node metastasis, metastases, Leptomeningeal metastases , and intraspinal (epidural and intradural) metastasis, metastases, Leptomeningeal metastases were detected within six, seven and eight months, respectively, from the start of symptoms despite treating the intracranial metastasis, metastases, Leptomeningeal metastases with gamma knife and the abdominal metastasis, metastases, Leptomeningeal metastases with surgical dissection and external radiotherapy. This indicates the aggressive nature of the disease. CONCLUSION: To the best of our knowledge, this is the first report in the literature of an intracranial meningeal metastasis, metastases, Leptomeningeal metastases of metastases of Merkel cell carcinoma, site of Merkel cell carcinoma, Merkel cell carcinoma treated with gamma knife and of intraspinal intradural metastases of Merkel cell carcinoma, site of Merkel cell carcinoma, Merkel cell carcinoma . Despite good initial response to radiotherapy, recurrence and occurrence of new metastasis, metastases, Leptomeningeal metastases are common in metastases of Merkel cell carcinoma, site of Merkel cell carcinoma, Merkel cell carcinoma .
| null |
709_biomrc
|
Title: Does home sleep testing impair continuous positive airway pressure adherence in @entity1 with XXXX ?
BACKGROUND: The increasing recognition of obstructive sleep apnea, OSA ( obstructive sleep apnea, OSA ) and demand for polysomnography has created a need for home sleep testing (HST) using unattended diagnostic and titration studies. Although these studies increase access to care and reduce cost, the limited interaction with sleep laboratories may negatively affect positive airway pressure ( obstructive sleep apnea, OSA86 ) adherence. We sought to determine the difference in obstructive sleep apnea, OSA86 use between HST and traditional in-laboratory studies. METHODS: This observational cohort study included 210 patients with obstructive sleep apnea, OSA classified into three equal groups. Following preestablished guidelines, group 1 underwent unattended, type III home diagnostic and unattended home auto-adjustable obstructive sleep apnea, OSA86 ( patients443 ) titrations; group 2 underwent in-laboratory, type I diagnostic and continuous obstructive sleep apnea, OSA86 titration studies; group 3 underwent type I diagnostic and patients443 titration studies. Group 1 was primarily managed and educated in a primary care clinic, whereas groups 2 and 3 received extensive education in an academic sleep medicine center. Objective measures of obstructive sleep apnea, OSA86 use during the first 4 to 6 weeks of therapy were compared between groups. RESULTS: Type of study and location of care did not affect obstructive sleep apnea, OSA86 adherence. obstructive sleep apnea, OSA86 was used for 70%, 73%, and 72% of nights in groups 1, 2, and 3, respectively (P = .94). Mean hours of nightly use (4.4 2.0 h, 4.7 1.5 h, and 4.6 1.5 h; P = .98) was also similar. Regular use was observed in 54%, 51%, and 50% of subjects (P = .84). Discontinuation rates were similar between groups. CONCLUSIONS: obstructive sleep apnea, OSA86 usage did not differ between those undergoing HST vs in-laboratory studies. HST offers a more accessible and cost-effective alternative without compromising therapeutic adherence.
| null |
707_biomrc
|
Title: Retrospective Assessment of @entity717 Criteria for Mild XXXX in @entity191 .
UNASSIGNED: A MDS, Movement Disorder Society ( MDS, Movement Disorder Society ) taskforce recently proposed diagnostic criteria for participants91 with features of mild cognitive impairment ( participants726 ). This study first examined the prevalence and nature of participants726 in a non-demented cohort using the MDS, Movement Disorder Society criteria. Using the generic Monte Carlo simulation method developed by Crawford and colleagues (2007), this study then estimated the base rate of the representative population who would demonstrate participants726 due to chance alone. A total of 104 participants with idiopathic participants726 underwent extensive motor and neuropsychological testing at baseline and 2 years later. The Unified participants91 Rating Scale (UPDRS) was used to assess motor symptoms of participants726 and a range of established neuropsychological tests was used to assess participants726 in accord with MDS, Movement Disorder Society criteria. In accord with MDS, Movement Disorder Society criteria, 38% of this cohort demonstrated participants726 at baseline and 48% at follow-up. Of the 36 participants in the multiple-domain participants726 subtype at time-1, 9 (25%) demonstrated no participants726 at follow up. Analysis revealed that approximately 13% of the representative population would demonstrate abnormally low scores for 2 of the 9 tests used, thereby meeting MDS, Movement Disorder Society criteria for participants726 . Clinicians and researchers need to approach a single diagnosis (i.e., based on one assessment) of participants726 with considerable caution. (JINS, 2015, 21, 1-9).
| null |
4808_biomrc
|
Title: XXXX , @entity2674 and @entity9517 mutations and @entity9516 @entity12096 in different South African ethnic groups diagnosed with premenopausal and/or @entity0 .
BACKGROUND: Current knowledge of the aetiology of inherited breast cancer, breast cancer, TNBC, hereditary breast cancer, triple negative breast cancer, premenopausal breast cancer in the four main South African population groups (black, coloured, Indian and white) is limited. Risk assessments in the black, coloured and Indian population groups are challenging because of restricted information regarding the underlying genetic contributions to inherited breast cancer, breast cancer, TNBC, hereditary breast cancer, triple negative breast cancer, premenopausal breast cancer in these populations. We focused this study on premenopausal participants, patients (diagnosed with inherited breast cancer, breast cancer, TNBC, hereditary breast cancer, triple negative breast cancer, premenopausal breast cancer before the age of 50; n = 78) and inherited breast cancer, breast cancer, TNBC, hereditary breast cancer, triple negative breast cancer, premenopausal breast cancer ( inherited breast cancer, breast cancer, TNBC, hereditary breast cancer, triple negative breast cancer, premenopausal breast cancer ) participants, patients (n = 30) from the four South African ethnic groups. The aim of this study was to determine the frequency and spectrum of germline mutations in BRCA1 , BRCA2 and PALB2 and to evaluate the presence of the CHEK2 participants, patients2096 allele in these participants, patients . METHODS: In total, 108 South African inherited breast cancer, breast cancer, TNBC, hereditary breast cancer, triple negative breast cancer, premenopausal breast cancer participants, patients underwent mutation screening using a Next-Generation Sequencing (NGS) approach in combination with Multiplex Ligation-dependent Probe Amplification (MLPA) to detect large rearrangements in BRCA1 and BRCA2 . RESULTS: In 13 (12 %) participants, patients a deleterious mutation in BRCA1/2 was detected, three of which were novel mutations in black participants, patients . None of the study participants, patients was found to have an unequivocal pathogenic mutation in PALB2 . Two (white) participants, patients tested positive for the CHEK2 participants, patients2096 mutation, however, one of these also carried a deleterious BRCA2 mutation. Additionally, six variants of unknown clinical significance were identified (4 in BRCA2 , 2 in PALB2 ), all in black participants, patients . Within the group of inherited breast cancer, breast cancer, TNBC, hereditary breast cancer, triple negative breast cancer, premenopausal breast cancer participants, patients , a higher mutation frequency was obtained (23.3 %; 7/30) than in the group of participants, patients diagnosed before the age of 50 (7.7 %; 6/78). CONCLUSION: This study highlights the importance of evaluating germline mutations in major inherited breast cancer, breast cancer, TNBC, hereditary breast cancer, triple negative breast cancer, premenopausal breast cancer genes in all of the South African population groups. This NGS study shows that mutation analysis is warranted in South African participants, patients with triple negative and/or in inherited breast cancer, breast cancer, TNBC, hereditary breast cancer, triple negative breast cancer, premenopausal breast cancer .
| null |
2761_biomrc
|
Title: Prospective study comparing XXXX or bevacizumab as adjuvant in trabeculectomy revision by needling.
PURPOSE: To compare the use of patients138 ( patients139 ) or bevacizumab ( patients493 ) as adjunctive in the needling revision of failed trabeculectomy blebs. METHODS: Glaucoma patients with failed trabeculectomy were included. Cystic blebs were excluded. All procedures were performed by the same surgeon at the operating room under peribulbar blockade. Rate of success, intraocular pressure (IOP), and number of antiglaucoma drugs in use were compared before and after the procedures. The IOP was measured postoperatively at days 1, 30, 90, and 180. Absolute success was defined as IOP <=18 mm Hg, without any complication or use of any antiglaucomatous drugs. Qualified success was the same criteria, but with the use of any antiglaucomatous drugs. RESULTS: Twenty-nine eyes of 29 patients were included: 15 eyes with patients139 and 14 eyes with patients493 . There was no statistical difference in the IOP reduction between the groups ( patients139 32.6 16.1% vs patients493 30.1 12.0%, p = 0.6). The patients493 group showed similar reduction in the number of antiglaucoma drugs compared to the patients139 group (p = 0.6). Absolute success was found in 28.5% of the patients493 group and in 6.6% of patients with patients139 . Qualified success was found in 64.3% and 73.4%, respectively, both limited to 180 days. CONCLUSIONS: In this selected and limited group of patients , bevacizumab can be considered as an alternative to patients139 in the needling revision of failed trabeculectomy. Studies with a larger number of patients and longer follow-up are needed to confirm the hypothesis suggested here.
| null |
4809_biomrc
|
Title: Effects of cultivation conditions on the uptake of @entity4250 and XXXX chemical species accumulated by Pteris vittata in hydroponics.
The physiological responses of the arsenic -hyperaccumulator, Pteris vittata, such as arsenic uptake and chemical transformation in the fern, have been investigated. However, a few questions remain regarding arsenic treatment in hydroponics. Incubation conditions such as aeration, arsenic concentration, and incubation period might affect those responses of P. vittata in hydroponics. arsenite, Arsenite uptake was low under anaerobic conditions, as previously reported. However, in an arsenite, Arsenite uptake experiment, phosphorous (P) starvation-dependent uptake of arsenate was observed under aerobic conditions. Time course-dependent analysis of arsenite, Arsenite oxidation showed that arsenite, Arsenite was gradually oxidized to arsenate during incubation. arsenite, Arsenite oxidation was not observed in any of the control conditions, such as exposure to a nutrient solution or to culture medium only, or with the use of dried root; arsenite, Arsenite oxidation was only observed when live root was used. This result suggests that sufficient aeration allows the rhizosphere system to oxidize arsenite, Arsenite and enables the fern to efficiently take up arsenite, Arsenite as arsenate . X-ray absorption near edge structure (XANES) analyses showed that long-duration exposure to arsenic using a hydroponic system led to the accumulation of arsenate as the dominant species in the root tips, but not in the whole roots, partly because up-regulation of arsenate uptake by P starvation of the fern was caused and retained by long-time incubation. Analysis of concentration-dependent arsenate uptake by P. vittata showed that the uptake switched from a high-affinity transport system to a low-affinity system at high arsenate concentrations, which partially explains the increased arsenate abundance in the whole root.
| null |
712_biomrc
|
Title: The right ventricular systolic to diastolic duration ratio: a simple prognostic marker in XXXX ?
AIMS: (i) To compare the ratio of right ventricular systolic to diastolic duration ( infants, Infants68 / DD ) in infants, Infants with CDH, congenital diaphragmatic hernia ( CDH, congenital diaphragmatic hernia ) and normal controls and (ii) to examine its association, if any, with outcomes in CDH, congenital diaphragmatic hernia . METHODS: Retrospective chart and echocardiographic review of consecutive neonates (<1 month old) with CDH, congenital diaphragmatic hernia and term controls without structural heart defects . Right ventricular infants, Infants68 / DD was calculated by a single reader. RESULTS: infants, Infants with CDH, congenital diaphragmatic hernia (n = 29) were comparable to controls (n = 27) in their mean ( infants, Infants68 ) age [2.2 (3.3) vs. 2 (4.0) days], birthweight [3 (0.67) vs. 3 (0.69) kg] and proportion of males (48.2% vs. 72.4%). The DD and infants, Infants68 / DD were significantly abnormal in the CDH, congenital diaphragmatic hernia group, compared to controls. Among infants, Infants with CDH, congenital diaphragmatic hernia , those who died (n = 15) and those who died or required ECMO (n = 17) had significantly shorter DD and higher infants, Infants68 / DD ratio. At a cut-off of 1.3, infants, Infants68 / DD ratio had a sensitivity of 92.8 (95% CI 64-99%) and specificity of 61.5 (32-85%) for prediction of mortality. Significant independent associations with mortality were observed with antenatal diagnosis (p = 0.003) and higher infants, Infants68 / DD ratio (p = 0.04). CONCLUSION: The right ventricular infants, Infants68 / DD ratio is a sensitive objective prognostic marker in infants, Infants with CDH, congenital diaphragmatic hernia . Further studies incorporating infants, Infants68 / DD ratio as a guide to intervention are warranted.
| null |
4813_biomrc
|
Title: A meta-analysis of published studies of XXXX does not support its routine clinical use.
BACKGROUND: endothelial dysfunction, Endothelial dysfunction is a marker of future CVD, cardiovascular disease ( CVD, cardiovascular disease ) risk, yet epidemiological studies have yielded inconsistent results. We therefore studied the association between endothelial dysfunction, Endothelial dysfunction and CVD, cardiovascular disease under diverse circumstances. METHODS AND RESULTS: Literature-based meta-analysis of prospective observational studies with >= 12 months of follow-up published in Medline and having information on endothelial function and CVD, cardiovascular disease outcomes. Tabular data on participants, participant, person, people characteristics, endothelial function assessments and incident CVD, cardiovascular disease outcomes were abstracted from individual studies. Random-effects meta-analysis was used to quantify pooled associations, and I(2) statistic to evaluate between-study heterogeneity. Potential sources of heterogeneity were explored by subgroup analyses and meta-regression. Thirty five studies involving 17,206 participants, participant, person, people met the inclusion criteria. During more than 80,000 participants, participant, person, people -years of observation, up to 2755 CVD, cardiovascular disease events were accrued, yielding a pooled relative risk (RR) of 1.25 (95% confidence interval 1.15-1.35) for CVD, cardiovascular disease comparing top (i.e. more severe) vs. bottom (less severe) third of endothelial dysfunction, Endothelial dysfunction . There was significant between-study heterogeneity and evidence of publication bias. RRs varied importantly according to the method used to ascertain endothelial function, and were higher among older individuals and among participants, participant, person, people with risk factors for CVD, cardiovascular disease or established CVD, cardiovascular disease at baseline. CONCLUSIONS: Although endothelial dysfunction, Endothelial dysfunction is an important determinant of cardiovascular outcomes in participants, participant, person, people with pre-existing CVD, cardiovascular disease , current evidence base does not support its use as a potentially useful measurement for risk stratification in participants, participant, person, people at lower risk of CVD, cardiovascular disease .
| null |
4815_biomrc
|
Title: Non @entity2067 Oral Anticoagulants versus @entity1229 for XXXX with @entity955 : Absolute Benefit and Harm Assessments yield Novel Insights.
BACKGROUND _ OBJECTIVES: Benefits and/or harms (including costs) of non- vitamin K oral anticoagulants (NOACs) versus patients, patient229 therapy need appreciation in relative and absolute terms. METHODS: Accordingly, we derived clinically relevant relative and absolute benefit/harm parameters for NOACs ( Apixaban, apixaban , dabigatran , rivaroxaban , patients, patient4242 ) compared to patients, patient229 from four clinical trials involving atrial fibrillation, AF ( atrial fibrillation, AF ) patients, patient . For each trial, we tabulated patients, patient numbers enduring four important outcomes and calculated unadjusted relative risk reduction (RRR) and number needed to treat (NNT)/year values (and 95% confidence intervals) for the NAOC compared to patients, patient229 . These outcomes were : stroke/systemic embolism (primary-endpoint), bleeding, bleeds, haemorrhagic-stroke , major bleeding, bleeds, haemorrhagic-stroke , and death . We also addressed drug acquisition costs. RESULTS: Each NOAC was non-inferior to patients, patient229 for primary-outcome prevention; RRRs were 12-33% and NNT/year values were 182-481, and all but one indicated statistically significant superiority. All the NOACs yielded statistically significant reductions in bleeding, bleeds, haemorrhagic-stroke risk; RRRs were 42-74% and NNT/year values were 364-528. Major bleeding, bleeds, haemorrhagic-stroke risk was comparable in both groups. Apixaban, apixaban yielded a lower NNT/year for preventing death than for primary-outcome prevention. Compared to patients, patient229 , NOAC acquisition costs were 70-140 fold greater. CONCLUSIONS: For the primary-outcome, the absolute benefits of NOACs were modest (NNT/year values being large). Reduced bleeding, bleeds, haemorrhagic-stroke rates with NOACs could be due to superior patients, patient188 prevention and fewer consequential haemorrhagic transformations. Among Apixaban, apixaban recipients, the absolute mortality benefit exceeded that for the primary-outcome, indicating prevention of additional unrelated deaths. The substantially greater NOAC acquisition costs need viewing against probable greater safety and the avoidance of monitoring bleeding, bleeds, haemorrhagic-stroke risks. This article is protected by copyright. All rights reserved.
| null |
4816_biomrc
|
Title: Environmental exposure to XXXX in New Caledonia: a case-control study.
A case-control study on respiratory cancers, cancer, laryngeal cancers was conducted in New Caledonia (South Pacific), where a high incidence of malignant pleural mesothelioma had been observed. The disease pattern suggested an environmental exposure to women, men355 . The first results showed that, in some areas, tremolite women, men355 derived from local outcroppings was used as whitewash (locally named "p "). All cases diagnosed between 1993 and 1995 (including 15 lung cancers, lung cancer615 , 228 lung cancers, lung cancer , and 23 respiratory cancers, cancer, laryngeal cancers ) and 305 controls were included in the study. Detailed information on past or present use of the whitewash, residential history, smoking, diet, and occupation was collected. The risk of lung cancers, lung cancer615 was strongly associated with the use of the whitewash (odds ratio (OR) = 40.9; 95% confidence interval (CI): 5.15, 325). All Melanesian cases had been exposed. Among Melanesian women, men , exposure to the whitewash was associated with an increased risk of lung cancers, lung cancer (OR = 4.89; 95% CI: 1.13, 21.2), and smokers exposed to po had an approximately ninefold risk (OR = 9.26; 95% CI: 1.72, 49.7) compared with women, men who never smoked and had never used the whitewash. In contrast, no association was noted between exposure to p and lung cancers, lung cancer risk among Melanesian women, men , probably because of lower exposure levels. Among non-Melanesians, the numbers of exposed subjects were too small to assess the effect of exposure to po. There was no indication of elevated risks for the other respiratory cancers, cancer, laryngeal cancers sites.
| null |
2769_biomrc
|
Title: Seasonal and geographical changes of spontaneous XXXX in the Japanese newt Cynops pyrrhogaster.
The occurrence of spontaneous skin papillomas in Japanese newts (Cynops pyrrhogaster) from Niigata prefecture in Northern Japan was monitored over four seasons covering a period of 2 years. Of 13,613 newts, 249 were found to papillomas, possess papillomas, higher papilloma, papilloma . The percentage of newts with papillomas, possess papillomas, higher papilloma, papilloma was highest in autumn, ranging from 1.93 to 5.45% of the total average. These values were more than four times as high as values obtained in the other three seasons (0.16 to 0.50%). A total of 12,167 newts were collected from their natural environment in 10 prefectures of Japan in the autumn of 1980 and 1981. Newts collected from the northern, seaside prefectures had papillomas, possess papillomas, higher papilloma, papilloma rates (1.00 to 5.45%) than did newts from the Southern, Pacific Ocean prefectures of Japan (0 to 0.27%). Male and female newts were affected equally often by the epitheliomas . herpes-type virus, Virus, virus -like bodies, resembling herpes-type virus, Virus, virus , were found in the cytoplasm of the epitheliomas . These herpes-type virus, Virus, virus -like bodies were not seen in the control epithelium of newts with normal skin and without papillomas, possess papillomas, higher papilloma, papilloma or in nonaffected regions of newts with papillomas, possess papillomas, higher papilloma, papilloma . It is suggested that tumor and herpes-type virus, Virus, virus are causally related.
| null |
4819_biomrc
|
Title: Physical work capacity and effect of endurance training in XXXX @entity1 and young male adults.
The purpose of the present study was to evaluate the relationship between several physical fitness parameters and eyesight divided into 3 grades in visually handicapped boys and young male adults, and to investigate the effect of mild exercise training on physical and boys109 as well as cardiorespiratory fitness . Four subjects were boys939 ( boys939 ), 6 were semi-blind (SB) and 27 had amblyopia (AM). Physical fitness tests consisted of maximal oxygen uptake (Vo2max), maximal pedalling speed and power, maximal stepping rate, and isometric knee extension strength. Compared with AM and SB groups, the boys939 group was inferior in all physical fitness parameters. Especially, Vo2max, in boys939 (26 ml.kg-1. boys009 ) was about 56% of that in age-matched Japanese sighted subjects and was significantly low compared with the AM and SB groups. Both muscle strength and maximal pedalling power corresponded to about 50% that of the age-matched sighted group. Six SB and 4 boys939 students (mean = 17.7 years) were trained for 6 weeks on a bicycle ergometer at an intensity of 50% VO2max. Training was undertaken for 3 days per week and maintained for 60 min per session. After training, physical and boys109 determined by the Cornell Medical Index improved significantly. These results indicate that low physical work capacity in visually handicapped boys and young male adults is due to the lack of physical activity, and that mild endurance training is effective in improving physical and boys109 as well as cardiorespiratory fitness .
| null |
4820_biomrc
|
Title: The Durability of Endoscopic Therapy for Treatment of @entity355 , XXXX , and Mucosal Cancer After Nissen Fundoplication.
INTRODUCTION: Radiofrequency ablation (RFA) endoscopic resection (EMR) is an established treatment strategy for neoplastic "Barretts and intramucosal cancer", cancer . Most patients, patient are managed with proton pump inhibitors. The incidence of recurrent "Barretts dysplasia", "Barretts metaplasia" , patients, patient141 , or "Barretts and intramucosal cancer", cancer after complete eradication is up to 43 % using this strategy. We hypothesize the addition of fundoplication should result in a lower recurrence rates after complete eradication. METHODS: Multi-institutional retrospective review of patients, patient undergoing endotherapy followed by Nissen fundoplication RESULTS: A total of 49 patients, patient underwent RFA EMR followed by Nissen fundoplication. Complete remission of intestinal metaplasia (CR-IM) was achieved in 26 (53 %) patients, patient , complete remission of patients, patient141 (CR-D) in 16 (33 %) patients, patient , and 7 (14 %) had persistent neoplastic Barrett's. After fundoplication, 18/26 (70 %) remained in CR-IM. An additional 10/16 CR-D achieved CR-IM and 4/7 with persistent patients, patient141 achieved CR-IM. One patients, patient progressed to LGD while no patients, patient developed HGD or "Barretts and intramucosal cancer", cancer . CONCLUSION: Endoscopic therapy for "Barretts dysplasia", "Barretts metaplasia" and/or intramucosal "Barretts and intramucosal cancer", cancer followed by fundoplication results in similar durability of CR-IM to patients, patient being managed with PPIs alone after endoscopic therapy. However, fundoplication may be superior in preventing further progression of disease and the development of "Barretts and intramucosal cancer", cancer . Fundoplication is an important strategy to achieve and maintain CR-IM, and facilitate eradication of persistent patients, patient141 .
| null |
4821_biomrc
|
Title: Serologic changes following B lymphocyte depletion therapy for XXXX .
OBJECTIVE: To explore the changes in serologic variables and clinical disease activity following B lymphocyte depletion in 22 patients with rheumatoid arthritis, RA ( rheumatoid arthritis, RA ). METHODS: B lymphocyte depletion was attained using combination therapy based on the monoclonal anti- CD20 antibody rituximab. Levels of a serologic indicator of inflammation , patients851 ( patients851 ), of antimicrobial antibodies, of autoantibodies including IgA-, IgM-, and IgG-class rheumatoid factors (RF), and of antibodies to cyclic citrullinated peptide (anti-CCP) were assayed. RESULTS: The majority of patients showed a marked clinical improvement after treatment with rituximab, with benefit lasting up to 33 months. Levels of total serum immunoglobulins fell, although the mean values each remained within the normal range. Whereas the IgM-RF response paralleled the changes in total serum IgM levels, the levels of IgA-RF, IgG-RF, and IgG and anti-CCP antibodies decreased significantly more than did those of their corresponding total serum immunoglobulin classes. The kinetics for the reduction in patients851 levels also paralleled the decreases in autoantibody levels. In contrast, levels of antimicrobial antibodies did not change significantly. B lymphocyte return occurred up to 21 months posttreatment. The time to relapse after B lymphocyte return was often long and unpredictable (range 0-17 months). Relapse was, however, closely correlated with rises in the level of at least one autoantibody. Increased autoantibody levels were rarely observed in the absence of clinical change. CONCLUSION: Following B lymphocyte depletion in patients with rheumatoid arthritis, RA , a positive clinical response occurred in correlation with a significant drop in the levels of patients851 and autoantibodies. Antibacterial antibody levels were relatively well maintained. B lymphocyte return preceded relapse in all patients . There was also a temporal relationship between clinical relapse and rises in autoantibody levels. Although these observations are consistent with a role for B lymphocytes in the pathogenesis of rheumatoid arthritis, RA , the precise mechanisms involved remain unclear.
| null |
4823_biomrc
|
Title: Hindlimb XXXX occurs from @entity1897 in a @entity35 @entity9 model.
OBJECTIVE: The purpose of this study was to examine the effect of neuropathic pain produced by peripheral nerve damage on mass, myofibrillar protein content, and cross-sectional areas of Type I and II fibers of rat, Sprague-Dawley rats, rats hindlimb muscles. METHOD: Adult male rat, Sprague-Dawley rats, rats were assigned to one of three groups: a pain group (n = 10) that underwent ligation and cut of the left L5 spinal nerve, a sham group (n = 10) that underwent a sham cut procedure, or a control group (n = 10) that underwent no procedures. The withdrawal threshold test was done to assess pain threshold on each of Days 1-7 and 14. Activity, body weight, and food intake were measured daily for 2 weeks. At 15 days, rat, Sprague-Dawley rats, rats were anesthetized and the bilateral soleus, plantaris, and gastrocnemius muscles dissected. RESULTS: At 15 days post-ligation, the pain group had significant decreases in total dietary intake, body weight, activity, and muscle weight as compared to sham and control animals. Muscle weight and cross-sectional area of Type II fiber of the ipsilateral soleus, plantaris, and gastrocnemius muscles decreased as did myofibrillar protein content of the ipsilateral plantaris and gastrocnemius muscles . Muscle weight of the contralateral gastrocnemius muscle decreased, as did myofibrillar protein content and cross-sectional area of Type II fiber of the contralateral plantaris muscle. CONCLUSION: Hindlimb muscle atrophy occurs in both ipsilateral and contralateral sides following induction of neuropathic pain by unilateral peripheral nerve damage . Muscle changes of the ipsilateral side are more pronounced than those of the contralateral side.
| null |
4824_biomrc
|
Title: A novel repressor-type homeobox gene, ved, is involved in @entity58295 / @entity58295 -mediated dorsal organizer formation in XXXX .
Dharma/Bozozok, Boz, boz (Dha/ Dharma/Bozozok, Boz, boz ) is a homeodomain protein containing an Engrailed homology (Eh) 1 repressor motif. It is important in zebrafish dorsal organizer formation. Dha/ Dharma/Bozozok, Boz, boz interacted with a co-repressor Groucho through the Eh1 motif. Expression of a Dha/ Dharma/Bozozok, Boz, boz fused to the transcriptional activator VP16 repressed dorsal axis formation and the expression of organizer genes but led to the dorsal expansion of expression of the homeobox gene vox/ vega1, Vega1 , indicating that Dha/ Dharma/Bozozok, Boz, boz functions as a transcriptional repressor for dorsal axis formation. We also isolated a novel homeobox gene, ved, whose expression was negatively regulated by dha/ Dharma/Bozozok, Boz, boz . ved's sequence and expression profile were similar to those of vox/ vega1, Vega1 and Vent, Vega2, vega2, vent / Vent, Vega2, vega2, vent . Like Vox/ vega1, Vega1 and Vent, Vega2, vega2, vent / Vent, Vega2, vega2, vent , Ved acted as a transcriptional repressor. The combined inhibition of ved, vox/ vega1, Vega1 , and Vent, Vega2, vega2, vent / Vent, Vega2, vega2, vent , by antisense morpholino injection, strongly dorsalized the embryos and elicited ventral expansion of organizer gene expression, compared with the effect of inhibiting each of these genes alone. These results suggest that ved is a target for the repressor Dha/ Dharma/Bozozok, Boz, boz . Ved functions redundantly with vox/ vega1, Vega1 and Vent, Vega2, vega2, vent / Vent, Vega2, vega2, vent to restrict the organizer domain.
| null |
2777_biomrc
|
Title: Simultaneous Solvent and Counterion Effects on the Absorption Properties of a Model of the XXXX Chromophore.
The ASEP/ MD (averaged solvent electrostatic potential from molecular dynamics) method was employed in studying the environment effects (solvent and counterion) on the absorption spectrum of a model of the 11-cis-retinal protonated Schiff base . Experimental studies of the absorption spectra of the rhodopsin chromophore show anomalously large solvent shifts in apolar solvents. In order to clarify their origin, we study the role of the counterion and of the solute-solvent interactions. We compare the absorption spectra in the gas phase, cyclohexane , dichloromethane , and methanol . The counterion effect was described from both a classical and quantum point of view. In the latter case, the contribution of the chromophore-counterion charge transfer to the solvent shift could be analyzed. To the best of our knowledge, this is the first time that counterion and solvent effects on the absorption properties of the 11-cis-retinal chromophore have been simultaneously examined. We conclude that the counterion-solute ionic pair in the gas phase is not a good model to represent the solvent shift in nonpolar solvents, as it does not account for the effect that the thermal agitation of the solvent has on the geometry of the ionic pair. In contrast to nonpolar solvents, the experimental solvent shift values in methanol can be exclusively explained by the polarity of the medium. In dichloromethane , the presence of the counterion does not modify the solvent shift of the first absorption band, but it affects the position of the second excited state. In the three solvents considered, the first two excited states become almost degenerate.
| null |
731_biomrc
|
Title: Response to upright exercise after XXXX .
The left ventricular response to upright bicycle exercise was studied in 39 unselected, non-beta blocked patients, men (mean(SEM) age 54.2(1.7)yr) (mean(SEM) resting ejection fraction 41.9(2.3)%) 8-10 weeks after myocardial infarction . Nine healthy, age matched, sedentary adult patients, men were studied for comparison (mean(SEM) age 49.8(0.9)yr). The stroke volume and cardiac output were measured by impedance cardiography at rest and after each 3 min workload until symptom limited maximum. The patients, men were separated into three groups based on stroke volume response to graded exercise. Group 1 (n = 14) had a normal stroke volume response to increasing heart rate. In group 2 (n = 13) stroke volume increased initially then decreased by greater than 15% at a heart rate greater than 100-105 beats. patients, men009 . In group 3 (n = 12) stroke volume failed to increase during exercise. In group 1 cardiac output and mean arterial pressure increased whereas vascular resistance decreased during exercise in a normal fashion. Group 2 had an increased mean arterial pressure and systemic vascular resistance throughout exercise while heart rate increased in a similar fashion to group 1 until work of greater than 70 W was undertaken, at which time heart rate increased in a curvilinear fashion and cardiac output was attenuated. Group 3 had an attenuated cardiac output and a higher heart rate during exercise. In this group of patients, men systemic vascular resistance failed to decrease normally during exercise.(ABSTRACT TRUNCATED AT 250 WORDS)
| null |
2781_biomrc
|
Title: @entity39 and XXXX with @entity1988 , Fifteen Years after Initial Diagnosis of @entity8 .
Renal involvement in patients252 ( patients252 ) is usually immune complex mediated and may have multiple different presentations. Pauci-immune necrotizing and crescentic glomerulonephritis (NCGN) refers to extensive membranous nephropathy, glomerular inflammation with few or no immune deposits that may result in rapid decline in renal function. We report a case of a 79-year-old Hispanic male with a history of secondary membranous nephropathy, glomerular inflammation (diagnosed by renal biopsy 15 years previously) who was admitted with membranous nephropathy, glomerular inflammation10 and active urinary sediment. P-ANCA titers and anti-myeloperoxidase antibodies were positive. The renal biopsy was diagnostic for NCGN superimposed on a secondary membranous nephropathy, glomerular inflammation . A previous diagnosis of patients252 based on American College of Rheumatology criteria was discovered via Veteran's Administration records review after the completion of treatment for pauci-immune NCGN. ANCAs are detected in 20-31% of patients with patients252 . There may be an association between patients252 and ANCA seropositivity. In patients with patients988 and biopsy findings of necrotizing and crescentic glomerulonephritis , without significant immune complex deposition, ANCA testing should be performed. In patients with secondary membranous nephropathy, glomerular inflammation patients252 should be excluded.
| null |
734_biomrc
|
Title: XXXX : characteristics and surgical outcomes of a contemporary series of 21 cases in an Egyptian referral center.
OBJECTIVE: To investigate the demographic, clinical, radiological, pathological and surgical features and outcomes of children, patients, Children, PATIENTS, infants313 , the second most common tumor, neoplasm in children, patients, Children, PATIENTS, infants . children, patients, Children, PATIENTS, infants AND METHODS: We conducted a retrospective study in the Department of Pediatric Neurosurgery at the Abo El-Reish children, patients, Children, PATIENTS, infants 's Hospital from 2005 to 2008. RESULTS: Out of 451 children, patients, Children, PATIENTS, infants with primary children, patients, Children, PATIENTS, infants313 (age 0-14 years), 21 children, patients, Children, PATIENTS, infants (<1 year) underwent surgery, representing 4.7% of total cases. The most common tumor, neoplasm was choroid plexus papilloma (23.8%), followed by teratoma (19%) then astrocytoma and ependymoma (14.3% each). Of the 21 surgical cases, 90% were intra-axial, 80% were in the supratentorial region, and 57% were intraventricular. There was only 1 case of intraoperative mortality (4.8%). Gross total excision was achieved in 65%, debulking in 30%, and biopsy in 5%. Three children, patients, Children, PATIENTS, infants received chemotherapy, but none received radiotherapy. The statistically significant predictors of prognosis were the extent of resection and tumor, neoplasm grade. CONCLUSION: Although the prognosis for children, patients, Children, PATIENTS, infants313 is worse than for older children, patients, Children, PATIENTS, infants , an overall promising outcome with low operative morbidity and mortality was achieved using gross total excision and appropriate adjuvant chemotherapy as part of a multidisciplinary approach.
| null |
4831_biomrc
|
Title: [Cardio-vascular system condition in XXXX ].
The study enrolled 53 patients (29 males, 24 females) with patients576 aged 15-88 years. Most of them were 59 years of age and younger. In 1/3 of the patients the diseases started with symptoms of patients729 , in 2/3 of them--with pulmonary affection. Pneumonia was diagnosed in 50 patients (94.3%), acute bronchitis --in 3 patients . ECG changes were registered in about half of the examinees who had no cardiac complaints. 25 of them had alterations in the end part of the ventricular ECG complex; rhythm and conduction disturbances occurred rarely. Mycoplasmosis patients suffering from IHD, ischemic heart disease ( IHD, ischemic heart disease ) had stable ECG changes while in those free of IHD, ischemic heart disease the changes were short. Myocardial necrosis, myocardial infections foci were absent. Cardiac damage comparison in patients with patients576 and in other patients729 has found that cardiovascular system suffers less in acute mycoplasmosis. These data are useful in differential diagnosis of Myocardial necrosis, myocardial infections .
| null |
2784_biomrc
|
Title: Effects of XXXX on suppressed and non-suppressed responding in the @entity2608 .
The effects of the putative 'anxiogenic' compound beta-carboline-3-carboxylic acid ethyl ester, beta-CCE ( beta-carboline-3-carboxylic acid ethyl ester, beta-CCE ) were studied on non-suppressed and suppressed responding of rhesus monkeys . Responding was maintained under a fixed-interval 2 min schedule of food presentation (non-suppressed responding) and a fixed-interval 2 min schedule of food presentation where each 10th response produced a 3-5 mA footshock (suppressed responding). Rates of suppressed responding were 60-90% lower than those for non-suppressed responding. beta-CCE reliably decreased non-suppressed responding over the range of 0.03-0.3 mg/kg (ED50 approximately 0.04 mg/kg) while consistent decreases in suppressed responding were not obtained in all animals until doses of 1-3 mg/kg (ED50 approximately 2 mg/kg) were given. Doses of beta-CCE greater than 0.01 mg/kg slightly increased blood pressure, moderately increased heart rate and greatly increased plasma ACTH levels for both types of response. In contrast, diazepam, Diazepam increased suppressed responding without affecting non-suppressed responding at low doses (0.3-1 mg/kg), while higher doses were required to decrease suppressed responding. diazepam, Diazepam had little effect on blood pressure or mean heart rate. Ro 15-1788 (1 mg/kg) blocked the rate-decreasing effects of beta-CCE on non-suppressed responding, suggesting the decrease is mediated via a benzodiazepine recognition site. These results show that under conditions where relatively low doses of diazepam, Diazepam have an anxiolytic effect (i.e. selectively increase rates of suppressed responding), relatively low doses of beta-CCE selectively decrease non-suppressed responding, questioning current notions of how to define an anxiogenic drug effect.
| null |
737_biomrc
|
Title: High early case XXXX after @entity64 in Poland: exploration of possible explanations in the International @entity64 Trial.
PURPOSE: To determine why Polish patients included in the International ischaemic stroke, stroke, Stroke Trial (IST) had a higher early case fatality than patients from other countries. METHODS: Of 19,435 patients randomised to IST, 17,370 had CT or autopsy-confirmed ischaemic stroke, stroke, Stroke . We compared the baseline clinical state and 14-day case fatality of patients randomised in Polish centres with those from all other IST countries. We examined: age, gender, presence of atrial fibrillation, AF ( atrial fibrillation, AF ), conscious level, neurological deficit , cause of death, deaths and patients17 use in the 3 days before ischaemic stroke, stroke, Stroke . RESULTS: In Poland, the 14-day case fatality rate was significantly higher than in other IST countries (13% vs. 9.6%; odds ratio, OR, 1.5, 95% confidence interval, CI, 1.2-1.9). In Poland, a significantly higher proportion of death, deaths was attributed to coronary heart disease (2.5% vs. 0.7%) and patients151 (1.0% vs. 0.4%). Polish patients had higher percentage of atrial fibrillation, AF and drowsiness, but were younger. When these factors were adjusted for, Polish patients still had approximately a 57% higher risk of death, deaths within 14 days compared with other countries. A logistic regression analysis revealed that an increased risk of death, deaths within 14 days in Poland compared to other IST patients was present among patients younger than 75 years (OR 1.7; 95% CI 1.3-2.4), females (OR 1.8; 95% CI 1.3-2.5), patients who were alert at onset (OR 2.4; 95% CI 1.7-3.4), with partial anterior circulation syndrome (PACS) (OR 2.0; 95% CI 1.4-2.8) or lacunar syndrome, LACS ( lacunar syndrome, LACS ) (OR 2.4; 95% CI 1.1-5.0) and without atrial fibrillation, AF (OR 1.8; 95% CI 1.3-2.4). Polish patients were less likely to have been on patients17 before their ischaemic stroke, stroke, Stroke than other countries (7.6% vs. 20.8%). CONCLUSION: The 14-day case fatality was significantly higher in Poland than in other countries in IST. Part of the increase was due to greater ischaemic stroke, stroke, Stroke severity in the Polish patients . However, differences persisted even after adjustment for baseline ischaemic stroke, stroke, Stroke severity. Several factors may have contributed the excess: poor attention to treatment of cardiovascular disease , less attention to treatment of secondary complications of ischaemic stroke, stroke, Stroke and some other--as yet unidentified--factor specific to Poland.
| null |
4834_biomrc
|
Title: Molecular mechanisms of apoptosis induced by XXXX .
1-(3-C-Ethynyl-beta-D-ribo-pentofuranosyl)cytosine, "3-Ethynylcytidine" ( 1-(3-C-Ethynyl-beta-D-ribo-pentofuranosyl)cytosine, "3-Ethynylcytidine" ; ECyd), a ribonucleoside analog, has a potent cytotoxic activity against cancer-cell death, cancer cells. We have investigated the cancer-cell death, cancer induced by ECyd, focusing on its molecular mechanisms. In ECyd-treated cells, RNase L is activated and involved in JNK, c-jun NH(2)-terminal kinase ( JNK, c-jun NH(2)-terminal kinase ) phosphorylation, followed by induction of mitochondria-dependent apoptosis. The mechanism of JNK, c-jun NH(2)-terminal kinase phophorylation by RNase L was unknown. To investigate the mechanism, we performed the identification of RNase L -binding partners by proteomic approach using co-immunoprecipitation and mass spectrometry. We found that RNase L was associated with a protein (we named it Protein-190). At the same time, we observed that Protein-190 was amply phosphorylated. Furthermore, the participation of Protein-190 in the ECyd-induced apoptosis was supported by a knockdown experiment using small interfering RNA (siRNA). Thus, the number of ECyd-induced apoptotic cells was drastically decreased when Protein-190 was knocked-down. These results indicated Protein-190 as a regulator in apoptosis, and provide the possibility for a new clinical target in cancer-cell death, cancer chemotherapy.
| null |
4829_biomrc
|
Title: Influence of treatment with gum acacia on renal vascular responses in a XXXX model of @entity740 .
OBJECTIVE: This study was conducted in order to investigate the effects of Adenine, adenine -induced CKD, chronic kidney disease ( CKD, chronic kidney disease ) on renal blood flow and biochemical changes in rat, rats , and to assess the effect of treatment with gum acacia (GA) thereon. MATERIALS AND METHODS: CKD, chronic kidney disease was induced by feeding rat, rats with Adenine, adenine (0.25% w/w, five weeks). Concomitantly, some of these rat, rats were also given gum acacia (GA) (15% w/v in the drinking water). Before animals were sacrificed, changes in renal blood flow (RBF) were monitored in anaesthetized rat, rats preparations. Several biochemical and histological renal function tests were also conducted. RESULTS: Adenine, adenine -induced CKD, chronic kidney disease significantly impaired the vasopressor actions of acetylcholine , sodium nitroprusside and phenylephrine and concomitant treatment with GA abated these responses. Additionally, plasma concentrations of urea , creatinine , uric acid , indoxyl sulfate , nitrite and nitrate and urinary excretion of protein were all significantly increased by Adenine, adenine . GA significantly mitigated the severity of Adenine, adenine - induced changes. CONCLUSIONS: Adenine, adenine -induced CKD, chronic kidney disease in rat, rats significantly impaired renal vascular responses to acetylcholine , sodium nitroprusside and phenylephrine and this was mitigated by treatment with GA. This provides another experimental evidence for the usefulness of GA in the amelioration of CKD, chronic kidney disease .
| null |
740_biomrc
|
Title: The age factor for XXXX 's @entity1370 : Multiple doses render the adult @entity19 heart more susceptible to injury.
UNASSIGNED: Age is a known susceptibility factor for the patients370 of several anticancer drugs, including mitoxantrone ( patients500 ). The impact of anticancer drugs in young patients is underestimated, thus we aimed to evaluate the patients370 of patients500 in juvenile and adult animals. Juvenile (3 week-old) and adult (8-10 week-old) male CD-1 patients9 were used. Each group was treated with a 9.0mg/kg cumulative dose of patients500 or saline; they were maintained in a drug-free period for 3-weeks after the last administration to allow the development of late patients37 (protocol 1), or sacrificed 24h after the last patients500 administration to evaluate early patients370 (protocol 2). In protocol 1, no adult patients9 survived, while 2 of the juveniles reached the end of the protocol. High plasma aspartate aminotransferase/ alanine aminotransferase ratio and a high cardiac reduced/oxidized glutathione ratio were found in the surviving patients500 -treated juvenile patients9 . In protocol 2, a significant decrease in plasma creatine -kinase MB in juveniles was found 24h after the last patients500 -administration. Cardiac histology showed that both patients500 -treated populations had significant damage, although higher in adults. However, patients500 -treated juveniles had a significant increase in fibrotic tissue. The patients500 -treated adults had higher values of cardiac GSSG and protein carbonylation, but lower cardiac noradrenaline levels. For the first time, mature adult animals were shown to be more susceptible to patients500 as evidenced by several biomarkers, while young animals appear to better adjust to the patients500 -induced cardiac injury, cardiac damage . Even so, the higher level of fibrotic tissue and the histological damage showed that patients500 also causes cardiac injury, cardiac damage in the juvenile population.
| null |
2786_biomrc
|
Title: Increases in XXXX incidence among @entity1 who have sex with @entity1 undergoing repeat diagnostic @entity645 testing in Ontario, Canada.
OBJECTIVE: To estimate HIV incidence density for different exposure categories among Persons, person, people, men undergoing repeat testing in Ontario, Canada. METHODS: Persons, person, people, men using voluntary, diagnostic HIV testing at least twice were identified by computerized and manual record linkage. In the 1992-2000 period, 980 seroconverters and 340 994 repeat negative testers contributed 936 145 Persons, person, people, men years (PY) of observation. ID, Incidence density ( ID, Incidence density ) was calculated according to Kitayaporn et al. Poisson regression was used to evaluate differences in incidence. RESULTS: Among Persons, person, people, men who have sex with Persons, person, people, men (MSM), ID, Incidence density declined between 1992-1996, from 1.23 per 100 PY in 1992 to 0.79 per 100 PY in 1996 [relative risk (RR), 0.86 per year; 95% confidence interval (CI), 0.77-0.96]. Subsequently, ID, Incidence density increased to 1.39 per 100 PY in 1999 (RR, 1.18 per year; 95% CI, 1.05-1.34). In 2000, ID, Incidence density was 1.16 per 100 PY but this decrease was not statistically significantly different from 1999. MSM in their twenties had the highest ID, Incidence density in 1992-1996, but in 1996-2000 MSM in their thirties had the highest risk of infection . Among injecting drug users (IDU), ID, Incidence density decreased from 0.64 per 100 PY in 1992 to 0.14 per 100 PY in 2000 (RR, 0.87 per year; 95% CI, 0.80-0.94). Among heterosexuals, annual incidence remained constant at about 0.03 per 100 PY in 1992-2000. CONCLUSIONS: Increases in ID, Incidence density were identified among MSM from 1996 to 1999. These findings are consistent with other research. Continued vigilance and improved surveillance are needed to better understand and control the epidemic.
| null |
2791_biomrc
|
Title: Overexpression of XXXX intestinal oligopeptide transporter in @entity1 cells via adenoviral transduction.
PURPOSE: Our goals are to establish an in vitro screening system and to evaluate a new approach in improving oral absorption of peptides and peptide-like drugs by overexpression of the human intestinal oligopeptide transporter ( hPepT1 ). This study characterizes the expression of hPepT1 in human intestinal Caco-2 cells, rat intestinal epithelial cells (IEC-18), and human cervix epithelial cells (Hela) after adenoviral transduction. METHODS: A recombinant replication-deficient adenovirus carrying the hPepT1 gene was made and used as a vector for the expression of hPepT1 . The increase in the uptake permeability of cephalexin and Gly-Sar was determined. The effects of time, dose, apical pH, and substrate specificity were evaluated. RESULTS: A significant increase in the uptake permeability of Gly-Sar and cephalexin was found in all three cell lines after viral transduction. The increase of Gly-Sar permeability in Hela. IEC-18, and Caco-2 cells was 85-, 46-, and 15-fold respectively. Immunoblotting using an antibody against hPepT1 detected high levels of a 85-98-kDa protein in all three infected cell lines. Substrate permeability was dependent on time of Adenoviral infected, infection, Decreased infectivity , inward pH gradients, and multiplicity of Adenoviral infected, infection, Decreased infectivity (MOI). Adenoviral infected, infection, Decreased infectivity and lower hPepT1 expression were observed in differentiated Caco-2 cells. The uptake was inhibited by dipeptides and beta-lactam antibiotics but not human522 . CONCLUSIONS: Adenoviral infected, infection, Decreased infectivity Hela cells displayed a pronounced level of hPepT1 expression with a low background and high specificity to dipeptides . These features make this system a useful tool for screening of potential substrates. The success of overexpression of hPepT1 in Caco-2 and IEC-18 cells may lead to a novel approach in improving oral absorption of peptides and peptidornimetic drugs.
| null |
2792_biomrc
|
Title: Alloantibody responses to antigens recognized by rabbit antitrophoblast antisera in trophoblast and mononuclear cell (MNC) membranes by primary aborting XXXX before and after paternal leukocyte immunization.
PROBLEM: Because shared allogeneic antigens are expressed on peripheral blood lymphocytes, as well as trophoblasts, it has been proposed that lymphocyte transfusions may appropriately sensitize recurrent spontaneous aborters (RSA) to trophoblast and lead to pregnancy conservation. The degree to which these responses are affected by this treatment, however, has not been defined. METHOD: SDS - polyacrylamide gel electrophoresis ( SDS -PAGE) and Western blot analyses were used to study the alloantibody responses in RSA patients both before and after immunization with paternal leukocytes (MNC) against membrane proteins isolated from peripheral blood mononuclear cells (MNC), first trimester and full term chorionic villi (CV). RESULTS: A distinct set of antigens with apparent molecular weights of 32, 36, 41, 63, 65, and 85 kDa was identified in both MNC and trophoblast membranes by rabbit anti-trophoblast antisera. In addition, a 55 kDa protein was recognized by MNC membranes. Thirty-eight percent of primary RSA sera recognized this 55 kDa protein. After paternal MNC immunization, all primary RSA samples displayed increased reactivity or produced antibodies to this 55 kDa protein when compared with preimmunization sera. The protein was identified as MCP using a rabbit polyclonal anti- MCP antisera. In contrast, reactivity to the other antigens present in the membrane preparations decreased after paternal MNC immunization. CONCLUSION: Changes in immune reactivity in RSA patients after paternal MNC immunization suggest that immunization alters serum immune reactivity to MNC and trophoblast shared antigens.
| null |
747_biomrc
|
Title: Tissue expression of cytokines ( @entity1192 , @entity1199 , @entity650 , IL-12, @entity310 ) in XXXX in @entity1 .
In most malignant tumours, tumours, tumour disturbed production of cytokines and of their receptors can be noted. The main immune system cells engaged in malignant tumours, tumours, tumour regression with the involvement of cytokines include helper lymphocytes ( children, human, patients198 ), cytotoxic lymphocytes (Tc) and dendritic cells. It has been noted that cytokines are also produced by the cells of a malignant tumours, tumours, tumour . The present study aimed at immunocytochemical localisation of cytokines ( children, human, patients192 , children, human, patients199 , IL-6 , IL-12, TNF-alpha ) in children, human, patients892 in children, human, patients (n = 10). The studies were performed on surgical material following formalin fixation and embedding in paraffin. The control material involved children, human, patients reactive lymph nodes (n = 5). children, human, patients199 , IL-6 , IL-12 were detected in 4/10 examined cases. Expression of children, human, patients192 was highly pronounced, as in the control, and was detected in 6/9 examined children, human, patients . No TNF-alpha could be demonstrated in malignant tumours, tumours, tumour even if lymph node expression of the cytokine was demonstrated in the control. The studies pointed to a decreased production of antitumour cytokines in children, human, patients892 in children, human, patients , which might correspond to the progression of the malignant tumours, tumours, tumour .
| null |
751_biomrc
|
Title: Chemotherapy with @entity2664 in combination with continuous infusion @entity5713 for metastatic XXXX .
The efficacy of mitoxantrone, Mitoxantrone in combination with vinblastine, Vinblastine was assessed in 156 patients with metastatic breast cancer who had been treated previously with one or multiple chemotherapeutic regimens. mitoxantrone, Mitoxantrone was given by random assignment, either as a 10 mg/m2 single intravenous dose or in five consecutive daily fractions of 2 mg 2. vinblastine, Vinblastine was given as a continuous intravenous infusion of 1.2 mg/m2 daily for 5 days. In 115 evaluable patients previously treated with doxorubicin , 21 objective responses (18%) and 11 minor responses (10%) were observed with similar distribution in the two treatment groups. Median time to progression was 27 weeks and 23 weeks, respectively. Eight (32%) of 25 patients who had not received doxorubicin achieved objective remissions and two (8%) had minor responses. patients37 effects were similar for the two treatment schedules. Major patients37 were myelosuppression and neutropenic fever . Other patients37 were mild. patients370 , presumably caused by mitoxantrone, Mitoxantrone , occurred in four patients . The combination of mitoxantrone, Mitoxantrone and vinblastine, Vinblastine appeared to offer no advantage over single-agent therapy, probably because of the dosage reduction required by the overlapping myelosuppressive patients37 .
| null |
4848_biomrc
|
Title: Optimizing the flow of care for prevention and treatment of XXXX and @entity1151 .
Critically ill patients, patient have multiple risk factors for patients, patient150 and patients, patient151 . The majority of patients, patient with patients, patient151 have a lower extremity patients, patient150 as a source of origin. patients, patient151 causes a high mortality rate in the hemodynamically compromised individual. Awareness of risk factors relative to the development of patients, patient150 and patients, patient151 is important for the critical care nurse. Understanding the pathophysiology can help guide prophylaxis and treatment plans. The therapies, from invasive to mechanical, all carry risks and benefits, and are weighed for each patients, patient . The advanced practice nurse, whether in the direct or indirect role, has an opportunity to impact the care of the high risk patients, patient . Options range from teaching the nurse who is new to critical care, to teaching patients, patient and families. Development of multidisciplinary protocols and clinical pathways are ways to impact the standard of care. Improved delivery of care methods can optimize the care rendered in an ever changing field of critical care.
| null |
753_biomrc
|
Title: Two-dimensional versus three-dimensional CT angiography in analysis of anatomical suitability for stentgraft repair of XXXX .
BACKGROUND: The morphological analysis prior to endovascular abdominal aneurysm repair (EVAR) plays an important role in long-term outcomes. Post-imaging analysis of computed tomographic angiography (CTA) by three-dimensional reconstruction with central lumen line detection ( patients072 3D-CTA) enables measurements to be made in orthogonal slices. This might be more precise than equal post-imaging analysis in axial slices by two-dimensional computed tomographic angiography (2D-CTA). PURPOSE: To evaluate the intra- and interobserver variability of patients072 3D-CTA and 2D-CTA post-imaging analysis methods and the agreement between them in pre-EVAR suitability analysis of patients with patients028 ( patients028 ). MATERIAL AND METHODS: Anonymized CTA data-sets from 70 patients with patients028 were analyzed retrospectively. Length measurements included proximal and distal aortic neck lengths and total distance from the lower renal artery to the higher iliac bifurcation. Width measurements included proximal and distal neck diameters, maximum patients028 diameter and common iliac diameters just above the iliac bifurcations. The measurements were performed in random order by two vascular surgeons, twice per method with 1-month interval between readings. In the patients072 3D-CTA method we used semi-automated patients072 detection by software and manual measurements on CTA slices perpendicular to patients072 . The equal measurements in 2D-CTA were performed manually on axial CTA slices using a DICOM viewer workstation. The intra- and interobserver variability, as well as the agreement between the two methods were assessed by Bland-Altman test and bivariate correlation analysis. RESULTS: The intraobserver variability was significantly higher in 2D-CTA measurements for both readers. The interobserver variability was significant in 2D-CTA measurements of proximal neck dimensions while the agreement in patients072 3D-CTA analysis between the two readers was excellent in all studied parameters. The agreement between the two suitability analysis techniques was poor for both readers, especially in measurements of proximal neck's dimensions and in total aortoiliac length (p = 0.001). CONCLUSION: In pre-EVAR morphological evaluation of AAAs the patients072 -3D CTA post-imaging analysis has better intra- and interobserver correlation than 2D-CTA and might represent a useful tool for the proper selection of endograft's type and size.
| null |
756_biomrc
|
Title: Cognitive changes predict continued recovery of erectile functioning versus relapse after discontinuation of @entity7855 treatment for XXXX .
OBJECTIVE: To examine whether erectile functioning after termination of sildenafil, Sildenafil intake in men, participants, participant with psychogenic erectile dysfunction, ED ( erectile dysfunction, ED ) can be predicted with psychological measures. METHOD: The subjects in a nonrandomized controlled trial were 65 heterosexual men, participants, participant with acquired psychogenic erectile dysfunction, ED , aged 54.2 +/- 11 years. sildenafil, Sildenafil medication was taken as required before sexual activity, up to two times per week. Response to a global end point question ("Did the treatment you took during the study improve your physical response during sexual activity in the last 4 weeks?") was recorded after 6 weeks of sildenafil, Sildenafil use and, subsequently, 6 weeks without medication. Other measures of sexual functioning and cognitive predictor measures were also administered. RESULTS: Of the 65 men, participants, participant who commenced sildenafil, Sildenafil treatment, 37% withdrew from the study before follow-up assessment. At posttreatment, 89% of men, participants, participant reported that treatment had improved or cured their erectile functioning. At follow-up, 66% of men, participants, participant had maintained posttreatment gains. Response at follow-up could be predicted (p <.001) with 96% sensitivity and 50% specificity by entering changes in sexual self-confidence and the men, participants, participant 's rating of his partner's wish to continue treatment in a logistic regression model. Higher odds for recovery of erectile functioning were found in men, participants, participant reporting increased sexual self-confidence and the estimation that their partner wanted them to continue sildenafil, Sildenafil use. High pretreatment sexual desire was found to further increase the odds for positive responding at follow-up. CONCLUSIONS: The present results indicate that continued improvement of erectile functioning is possible after discontinuation of sildenafil, Sildenafil use in men, participants, participant with psychogenic erectile dysfunction, ED . Maintenance of gains can be predicted from cognitive changes before medication is withdrawn.
| null |
2808_biomrc
|
Title: Long-term results of aortic valvuloplasty for @entity337 associated with XXXX .
Long-term results in 64 patients, patient who underwent aortic valvuloplasty for aortic regurgitation associated with patients, patient757 are presented. The average age of the patients, patient was 10.2 years and the average cardiothoracic ratio was 0.57 at the time of operation. The average degree of aortic regurgitation , as classified by Sellers, was 2.7. The type of patients, patient757 was subpulmonic in 31 patients, patient , perimembranous in 20, and was a total conal defect in five patients, patient . Valvuloplasty was performed at one end of an aortic cusp in 23 patients, patient , at two ends in 33, at three ends in six, and at four ends in two patients, patient . There was one operative death (1.6%). The follow-up period was 447.7 patients, patient -years, and there were no late deaths. The actuarial survival rate was 98.3% at 5, 10, and 15 years. Postoperative cardiac catheterization was performed in 40 patients, patient . patients, patient77 was defined as the presence of a cardiothoracic ratio greater than 0.6, a loud regurgitant murmur (Levine grade 3/6 or greater), moderate or severe aortic regurgitation (Sellers grade 3 or 4), or the necessity of reoperation. There were 17 patients, patient whose valvuloplasty failed. The freedom from valvuloplasty failure was 74.2% at 5 and 10 years and 55.3% at 15 years. Eight patients, patient underwent reoperation because of residual aortic regurgitation , and all survived. The freedom from reoperation was 90.1% at 5 years, 80.5% at 10 years, and 63.7% at 15 years. Multiple regression analysis revealed that older age, a greater cardiothoracic ratio, perimembranous patients, patient757 , and multiple valvuloplasties were significant contributing factors for residual regurgitation after aortic valvuloplasty.
| null |
2810_biomrc
|
Title: Effect of donor pre-mortem XXXX and @entity551 on graft function and start of warm @entity63 in donation after @entity204 lung transplantation.
BACKGROUND: The start of warm ischemic time (WIT) of donor lungs in donation after cardiac death (DCD) is not clearly defined. We investigated the effect of donor pre-mortem HT, cardiac tamponade reducing systolic blood pressure, hypotension and hypoxia to determine which physiologic factor is the determinant of WIT onset in controlled DCD lung transplantation. METHODS: Twenty mechanically-ventilated donor pigs were placed in 4 groups (n = 5 each) and exposed to each of the pseudo-agonal conditions for 60 minutes: (1) control group, no intervention and optimum ventilation, followed by cardiac arrest ; (2) HT, cardiac tamponade reducing systolic blood pressure, hypotension ( HT, cardiac tamponade reducing systolic blood pressure, hypotension ) group, controlled HT, cardiac tamponade reducing systolic blood pressure, hypotension to <50 mm Hg, followed by cardiac arrest ; (3) hypoventilation, HV ( hypoventilation, HV ) group, ventilation with room air at 5 breaths/min, followed by cardiac arrest ; (4) non-circulation (NC) group, initial cardiac arrest , followed by a 60-minute standoff time. The lung graft was retrieved and the left lung was transplanted to the recipient. Graft function was evaluated for 4 hours after contralateral pulmonary artery ligation . The reperfusion injury was evaluated based on tissue cytokine expression, wet weight-to-dry weight ratio, and histology at the end of the reperfusion period. RESULTS: Impaired post-transplant graft function was seen in the hypoventilation, HV group, which had significantly poorer oxygenation during the reperfusion period than the other groups (p < 0.001). The hypoventilation, HV group also had higher tissue levels of interleukin-8 (p < 0.05), a higher wet weight-to-dry weight ratio (p < 0.05), and histologic findings of graft tissue injury than the control group. The difference in these parameters among the control, HT, cardiac tamponade reducing systolic blood pressure, hypotension , and NC groups was not significant. CONCLUSIONS: Only pre-mortem hypoxia provoked by hypoventilation, HV significantly impaired lung graft function in DCD lung transplantation. Ventilatory rather than circulatory deterioration can trigger the onset of warm ischemia .
| null |
2811_biomrc
|
Title: Sonography-guided percutaneous microwave ablation of intrahepatic primary XXXX .
OBJECTIVE: To evaluate the efficacy and safety of sonography-guided percutaneous microwave ablation of intrahepatic primary cholangiocarcinoma . MATERIALS AND METHODS: From May 2006 to March 2010, 15 women, patients, patient, men (11 women, patients, patient, men , 4 women, patients, patient, men ; mean age, 57.4 years) with 24 histologically proven intrahepatic primary cholangiocarcinoma lesions (mean tumor size, 3.2 1.9 cm; range, 1.3-9.9 cm) were treated with microwave ablation. RESULTS: Thirty-eight sessions were performed for 24 nodules in 15 women, patients, patient, men . The follow-up period was 4-31 months (mean, 12.8 8.0 months). The ablation success rate, the technique effectiveness rate, and the local tumor progression rate were 91.7% (22/24), 87.5% (21/24), and 25% (6/24) respectively according to the results of follow-up. The cumulative overall 6, 12, 24 month survival rates were 78.8%, 60.0%, and 60.0%, respectively. tumor32 occurred including liver abscess in two women, patients, patient, men (13.3%) and needle seeding in one women, patients, patient, men (6.7%). Both complications were cured satisfied with antibiotic treatment combined to catheter drainage for abscess and resection for needle seeding. The minor complications and side effects were experienced by most women, patients, patient, men which subsided with supportive treatment. CONCLUSION: Microwave ablation can be used as a safe and effective technique to treat intrahepatic primary cholangiocarcinoma .
| null |
764_biomrc
|
Title: Randomized trial of XXXX in combination with @entity3446 or @entity618 in kidney transplantation: results at 6 months.
BACKGROUND: This is the first report of a randomized, multicenter, clinical trial comparing the combination of sirolimus or posttransplant diabetes mellitus18 ( MMF ) with patients, Patient140 -based immunosuppression in kidney transplantation. Results at 6 months of follow-up are presented. METHODS: Before transplantation, patients, Patient were randomized to receive patients, Patient140 plus corticosteroids with sirolimus (n=185) or MMF (n=176). The primary endpoint of the study was the incidence of biopsy-confirmed acute rejection. patients, Patient and graft survival, renal function, and composite endpoints also were evaluated. Safety was assessed by monitoring laboratory parameters and adverse events. RESULTS: By 6 months of follow-up, the incidence of biopsy-confirmed acute rejection was similar in both treatment groups (13.0% patients, Patient140 + sirolimus vs. 11.4% patients, Patient140 + MMF ; P=0.64 log-rank). patients, Patient survival (97.3% patients, Patient140 + sirolimus vs. 97.7% patients, Patient140 + MMF ) and graft survival (93.0% patients, Patient140 + sirolimus vs. 95.5% patients, Patient140 + MMF ) were equivalent (P=0.53, overall survival log-rank). There was a significantly higher incidence of study drug discontinuation in patients, Patient receiving sirolimus (21.1% vs. 10.8%; P=0.008). Renal function was significantly better in the MMF -treatment group (serum patients, Patient011 1.44+/-0.45 mg/dL vs. 1.77+/-1.42 mg/dL; P=0.018). Hyperlipidemia, hyperlipidemia was significantly more prevalent in the sirolimus -treatment group. Diastolic blood pressure was significantly higher in sirolimus -treated patients, Patient . There were significantly more patients, Patient431 and gastrointestinal adverse events in the MMF -treatment group. The incidence of posttransplant diabetes mellitus was 7.6% in the sirolimus group and 7.7% in the MMF group. CONCLUSION: patients, Patient140 is equally effective in renal transplantation when combined with sirolimus or MMF . The patients, Patient140 - MMF combination may be superior in terms of improved renal function and improved cardiovascular risk factors including Hyperlipidemia, hyperlipidemia and patients, Patient01 .
| null |
765_biomrc
|
Title: Clinical efficacy of stereotactic ablative radiotherapy for lung metastases arising from XXXX .
BACKGROUND: Limited data describe the prognosis after stereotactic ablative radiotherapy for lung metastases arising from Patients, patients4 . Thus, we evaluated treatment outcomes of stereotactic ablative radiotherapy for those Patients, patients . METHODS: The study involved Patients, patients received stereotactic ablative radiotherapy for one to three lung metastases arising from Patients, patients4 at a single institution. A total dose of 40-60 Gy (median, 48 Gy) in three or four fractions was prescribed. RESULTS: A total of 79 metastatic lung lesions from 50 Patients, patients who underwent curative resection for their primary Patients, patients4 or salvage treatment at a recurrent site were included. The one- and three-year local control rates were 88.7 % and 70.6 %, respectively. The three-year overall survival and progression-free survival rates were 64.0 % and 24.0 %, respectively. Patients, patients with tumor volume <=1.5 mL had a significantly better overall survival rate than those with tumor volume >1.5 mL (68.0 % vs. 60.0 % at three-year, p = 0.02). Local control was associated with a trend towards better survival (p = 0.06). No pulmonary complications greater than grade 2 were observed. CONCLUSION: Stereotactic ablative radiotherapy is a competitive treatment modality for the management of lung metastases arising from Patients, patients4 .
| null |
767_biomrc
|
Title: The effects of compounds related to gamma-aminobutyrate and benzodiazepine receptors on behavioural responses to anxiogenic stimuli in the XXXX : extinction and successive discrimination.
In a first set of experiments rats were trained to run in a straight alley for food reward on a continuous reinforcement schedule and the running response was then extinguished. On the last 2 days of training and daily throughout extinction different groups of animals were injected IP with saline, 5 mg/kg Chlordiazepoxide, chlordiazepoxide , 0.75 mg/kg picrotoxin, Picrotoxin , Chlordiazepoxide, chlordiazepoxide + picrotoxin, Picrotoxin , Chlordiazepoxide, chlordiazepoxide + 1.5 mg/kg bicuculline , 0.00125 or 0.25 mg/kg muscimol , 1 mg/kg baclofen , Chlordiazepoxide, chlordiazepoxide + baclofen , or 0.00125 mg/kg muscimol + baclofen . Chlordiazepoxide, chlordiazepoxide increased resistance to extinction, a well-known anxiolytic effect. This effect was blocked by both picrotoxin, Picrotoxin and bicuculline . picrotoxin, Picrotoxin on its own reduced resistance to extinction (an anxiogenic-like effect). Whether given alone or in combination with other drugs, muscimol and baclofen had no effect. In a second set of experiments rats were trained in a successive operant discrimination (signalled by a flashing or steady light) between components in which sucrose reward was available on a variable-interval schedule for barpressing and components in which no reward was given. Chlordiazepoxide, chlordiazepoxide at 10 mg/kg increased responding in both rewarded and nonrewarded components, but more in the latter than could be accounted for by change in the former. This effect is as expected with an anxiolytic drug. It was not altered by administration of bicuculline at 1.5 or 1.75 mg/kg; at 2 mg/kg bicuculline acted synergistically with Chlordiazepoxide, chlordiazepoxide . picrotoxin, Picrotoxin (1 and 1.5 mg/kg) also acted synergistically with Chlordiazepoxide, chlordiazepoxide , enhancing the latter's rate-increasing effects, but only during rewarded components. Neither muscimol (0.00125 and 0.25 mg/kg) nor baclofen (0.01 mg/kg) affected response rates, whether given alone or in combination. However, baclofen in a dose of 1 mg/kg, provided it was given to rats also injected with muscimol (0.00125 or 0.25 mg/kg) at other times, significantly reduced responding during nonrewarded components (an apparently anxiogenic effect). The results of the two sets of experiments are discussed in relation to the hypothesis that anxiolytic drugs affect behaviour by increasing GABAergic inhibition.
| null |
2816_biomrc
|
Title: Newly diagnosed XXXX .
Melphalan combined with prednisone (MP) has been accepted as the standard therapy for previously untreated patients, patient582 ( patients, patient582 ) because most studies demonstrate only a modest survival benefit of combination chemotherapy regimens when compared with MP. There have been modest gains with more intensive myeloablative regimens in combination with blood stem cell support, particularly for patients, patient with early primary refractory disease who subsequently achieve partial remission, and for the approximately 25% to 35% of patients, patient achieving complete remission. To preserve the ability to adequately collect stem cells, the use of alkylating agents, such as melphalan, should be limited in the previously untreated patients, patient with patients, patient582 (including those older than 65 years of age) who is a candidate for myeloablative therapy. Pulse dexamethasone -containing regimens provide rapid responses and may be considered the first regimens of choice. Although patients, patient891 / doxorubicin / dexamethasone (VAD) produces responses in approximately 50% to 70% of patients, patient with previously untreated patients, patient582 , use early in the disease has not improved survival. Outside of a specific study protocol, this regimen may be best reserved for patients, patient with refractory (particularly relapsing) disease. Notable exceptions include patients, patient with patients, patient77 or plasma cell leukemia in whom the rapid responses provided by VAD may avoid potentially permanent, serious complications. Recently, new agents with novel mechanisms of action (ie, Thalidomide, thalidomide , immunomodulatory drugs, proteosome inhibitors) have demonstrated activity in resistant patients, patient582 . Because these agents are likely to show activity alone or in combination, newly diagnosed patients, patient and previously untreated patients, patient should be considered for clinical trials. Thalidomide, thalidomide / dexamethasone has already produced response rates of 65% to 75% in previously untreated patients, patient . Its ease of administration along with stem cell preservation are likely to make this, followed by myeloablative therapy with stem cell support, the treatment of choice for untreated patients, patient582 as confirmatory studies are completed.
| null |
4863_biomrc
|
Title: Endoscopic submucosal dissection for XXXX and noninvasive early gastrointestinal cancers.
AIM: To investigate the indication, feasibility, safety, and clinical utility of endoscopic submucosal dissection (ESD) in the management of various gastrointestinal pathologies. METHODS: The medical records of 60 consecutive patient, Patients, patients (34 female, 26 male) who underwent ESD at the gastroenterology department of Kocaeli University from 2006-2010 were examined. patient, Patients, patients selected for ESD had premalignant lesions or non-invasive cancers, tumor, cancer, carcinoid tumor, neuroendocrine tumor, early cancers of the gastrointestinal tract and had endoscopic and histological diagnoses. Early cancers, tumor, cancer, carcinoid tumor, neuroendocrine tumor, early cancers were considered to be confined to the submucosa, with no lymph node involvement by means of computed tomography and endosonography. RESULTS: Sixty ESD procedures were performed. The indications were epithelial lesions (n = 39) (33/39 adenoma with high grade patient, Patients, patients141 , 6/39 adenoma with low grade dysplasia ), cancers, tumor, cancer, carcinoid tumor, neuroendocrine tumor, early cancers (n = 7), cancers, tumor, cancer, carcinoid tumor, neuroendocrine tumor, early cancers (n = 7) (5/7 early patient, Patients, patients4 , 2/7 early gastric cancer ), granular cell cancers, tumor, cancer, carcinoid tumor, neuroendocrine tumor, early cancers (n = 3), gastrointestinal stromal tumor (n = 2), and leiomyoma (n = 2). En bloc and piecemeal resection rates were 91.6% (55/60) and 8.3% (5/60), respectively. Complete and incomplete resection rates were 96.6% (58/60) and 3.3% (2/60), respectively. Complications were major bleeding [n = 3 (5%)] and perforations [n = 5 (8.3%)] (4 colon, 1 stomach). Two patient, Patients, patients with colonic perforations, colonic adenocarcinoma and two patient, Patients, patients with submucosal lymphatic and microvasculature invasion (1 gastric cancers, tumor, cancer, carcinoid tumor, neuroendocrine tumor, early cancers , 1 colonic perforations, colonic adenocarcinoma ) were referred to surgery. During a mean follow-up of 12 mo, 1 patient, Patients, patients with adenoma with high grade patient, Patients, patients141 underwent a second ESD procedure to resect a local recurrence. CONCLUSION: ESD is a feasible and safe method for treatment of premalignant lesions and early malignant gastrointestinal epithelial and subepithelial lesions . Successful en bloc and complete resection of lesions yield high cure rates with low recurrence.
| null |
2822_biomrc
|
Title: Presenting complaint among @entity1 with XXXX who present to an urban, public hospital emergency department.
STUDY OBJECTIVE: We determine the frequency of women, patients, patient, Women, men presenting without a primary complaint of chest pain who are admitted with AMI, acute myocardial infarction ( AMI, acute myocardial infarction ) and identify factors associated with an increased risk of a presentation without chest pain . METHODS: This was a retrospective, cross-sectional study over a 5-year period (July 1, 1993, to June 30, 1998) of women, patients, patient, Women, men presenting to a large urban, public hospital emergency department who were admitted and determined to have an AMI, acute myocardial infarction based on International Classification of Diseases, 9th Revision, coding and chart review. Main outcome measures were prevalence of presentation without chest pain and prevalence of other predefined presentations (ie, women, patients, patient, Women, men353 , women, patients, patient, Women, men167 , abdominal pain , women, patients, patient, Women, men296 / weakness / women, patients, patient, Women, men163 ) as determined by the primary chief complaint entered on arrival at the ED . We calculated univariate relative risks and multivariate odds ratios (ORs) for presentation without chest pain in women, patients, patient, Women, men , nonwhite ethnic groups, and older age groups. RESULTS: Of the 721 cases of diagnosed AMI, acute myocardial infarction , 53% (380; 95% confidence interval [CI] 49% to 56%) of women, patients, patient, Women, men presented with chest pain . The frequency of other complaints were women, patients, patient, Women, men353 , 17% (121); women, patients, patient, Women, men167 , 7% (50); women, patients, patient, Women, men296 / weakness / women, patients, patient, Women, men163 , 4% (32); abdominal pain , 2% (14); and other, 17% (124). The risk of a presentation without chest pain in a women, patients, patient, Women, men with AMI, acute myocardial infarction increased with age. The characteristic with the highest risk for a presentation without chest pain in women, patients, patient, Women, men with AMI, acute myocardial infarction was age older than 84 years old (multivariate OR 5.76; 95% CI 3.06 to 10.83). women, patients, patient, Women, men were more likely than women, patients, patient, Women, men to present without chest pain (multivariate OR 1.59; 95% CI 1.11 to 2.28). CONCLUSION: Our results demonstrate that women, patients, patient, Women, men with AMI, acute myocardial infarction commonly present to the ED without a primary initial complaint of chest pain and that the frequency of initial presentations without chest pain in our urban, public hospital is as high or higher than that reported in the general ED population. Heightened awareness of atypical presentations may affect assessment of women, patients, patient, Women, men with AMI, acute myocardial infarction and provide further focus for research into presentations of women, patients, patient, Women, men187 other than chest pain .
| null |
4874_biomrc
|
Title: Vibrational spectrum associated with the reduction of XXXX radical D* in photosystem II: a comparative biochemical and kinetic study.
Photosystem II (PSII) contains a redox-active tyrosine , D. Difference FT-IR spectroscopy can be used to obtain structural information about this species, which is a neutral radical, D*, in the photooxidized form. Previously, we have used isotopic labeling, site-directed mutagenesis, and kinetics to assign a vibrational line at 1477 cm-1 to D*; these studies were performed on highly resolved PSII preparations at pH 7.5 Kim et al. (1998) Biochim. Biophys. Acta 1364, 337-360; publisher's correction, Biochim. Biophys. Acta 1366, 330-354 . Here, we use kinetics to assign vibrational features to tyrosyl radical, D*, in PSII membranes. EPR and fluorescence controls identify a time regime in which D* decay occurs independently of redox changes involving the PSII quinone acceptors. Difference FT-IR spectra, acquired over this time regime, exhibit decreases in the amplitude of a 1477 cm-1 line; quantitative comparison with EPR transients supports the assignment to D*. Conditions, requiring the use of phosphate / formate , have been described for observation of a dissimilar FT-IR spectrum, which has been assigned to tyrosyl radical D*; this spectrum lacks a 1477 cm-1 line Hienerwadel et al. (1997) Biochemistry 36, 14712-14723 . Under these conditions, we have observed (1) an acceleration in the rate of D* decay and a decrease in D* yield attributable to the presence of formate , (2) a proportional decrease in the amplitude of FT-IR spectra acquired over the time regime in which D* decays, (3) frequency shifts in the D* - D FT-IR spectrum, (4) large-scale structural changes, as assessed by the amide I line shape, and (5) contributions to the FT-IR spectrum from the phosphate / formate buffer in the absence of PSII. We conclude that changes in the FT-IR spectrum, observed in the presence of phosphate / formate , are caused by alterations in the environment of D* and by direct phosphate / formate contributions to the spectrum.
| null |
779_biomrc
|
Title: Association of physical activity intensity levels with XXXX and @entity28 in a population-based sample of adults.
BACKGROUND: Clarify the association between physical activity intensity and overweight / obesity . METHODS: Population-based 1997-2001 survey in Geneva, Switzerland (n=5,757, ages 35 to 74). Intensity of physical activity energy expenditure (EE) defined as percentage of total EE in moderate activities [3-3.9 x basal metabolism rate (BMR), e.g., normal walking, household chores] and high-intensity activities (> or =4 x BMR, e.g., brisk walking, sports). Overweight or obesity based on measured body mass index (BMI). RESULTS: Comparing participants, women, people, men in the lowest vs. the highest tertile of the percentage of high-intensity EE, the odds ratios (ORs) were, for obesity vs. normal weight, 2.8 (95% confidence interval: 2.0-3.8, P<0.0001) in participants, women, people, men and 2.4 (1.7-3.4, P<0.0001) in participants, women, people, men . For obese vs. overweight , the participants, women, people, men / participants, women, people, men ORs were 1.9 (1.4-2.6, P<0.0001)/1.5 (1.0-2.2, P<0.05). For overweight vs. normal weight, the participants, women, people, men / participants, women, people, men ORs were 1.4 (1.1-1.7, P<0.002)/1.7 (1.3-2.1, P<0.0001). Less or no relationship was found for the percentage of moderate-intensity EE. CONCLUSIONS: This cross-sectional study cannot determine whether exercise is an effective strategy for weight control or whether overweight or obese participants, women, people, men exercise less. However, clear dose-response associations in both genders between obesity or overweight and energy expenditure in high (but not in moderate)-intensity activities are findings with potentially major public health implications meriting validation in an experimental intervention study.
| null |
2830_biomrc
|
Title: Effects of acute, subacute, and chronic XXXX on carbohydrate and energy metabolism in @entity35 sciatic nerve. Relation to mechanisms of peripheral neuropathy.
To address the problem of the pathogenesis of diabetic neuropathy , rats were made diabetic, diabetic nerve by alloxan administration, and sciatic nerves were sampled for electrolyte and water content and levels of selected carbohydrates and intermediates in energy metabolism at 3, 6, and 26 weeks. Significant increases were seen in the nerve content of glucose , sorbitol , and fructose . Decreases of myo-inositol were not statistically significant. Glucose-6-phosphate was increased at all times; fructose-1,6-bisphosphate was elevated at 6 and 26 weeks. Nerve ATP and phosphocreatine levels were both increased concomitantly, as was the energy charge. Nerve lactate, Lactate levels increased only at 26 weeks when plasma lactate, Lactate levels were also high. Plasma diabetic, diabetic nerve178 bodies were elevated throughout the 26-week experimental interval. It is postulated that diabetic, diabetic nerve178 bodies were being used as alternative metabolic fuels in diabetic, diabetic nerve , thereby causing inhibition of pyruvate oxidation and increased aerobic production of lactate, Lactate . Increased plasma diabetic, diabetic nerve178 body levels could also inhibit hepatic lactate, Lactate uptake. There was no other evidence for hypoxia / diabetic, diabetic nerve3 . lactate, Lactate : pyruvate ratios did not differ from control values at any time in these ketotic hypoinsulinemic animals. Five major hypotheses have been proposed to explain the pathogenesis of diabetic neuropathy : 1) hypoxia / diabetic, diabetic nerve3 , 2) hyperglycemic pseudohypoxia, 3) myo-inositol deficiency, 4) fructose and polyol accumulation and osmotic disequilibrium, and 5) nonenzymatic glycation of macromolecules by fructose and glucose . The data obtained in this study seem to fit best with hypotheses 4 and perhaps 5.
| null |
786_biomrc
|
Title: Platelet-derived microparticles induce polymorphonuclear leukocyte-mediated damage of XXXX pulmonary microvascular endothelial cells.
BACKGROUND: Platelets (PLTs) stored at 22 C accumulate microparticles and biologic response modifiers (BRMs) that induce inflammatory reactions in transfusion recipients. However, soluble BRMs are fully diluted in the recipient's blood circulation. The mechanisms by which BRMs exert their effects have not been elucidated. The objectives of this study were to determine the effect of PLT microparticles (PMPs) on polymorphonuclear leukocyte (PMN)-mediated human pulmonary microvascular endothelial cell (HMVEC) damage and determine the role of soluble CD40 ligand (sCD40L). STUDY DESIGN AND METHODS: PMPs were isolated from apheresis PLT concentrates. We used a two-insult in vitro model of HMVEC damage to investigate the effects of PMP and sCD40L and role of human2824 , an inhibitor of PMN respiratory burst. Their priming activities were measured using hydrogen peroxide production. The expression of ICAM-1, CD54, intercellular cell adhesion molecule-1 ( ICAM-1, CD54, intercellular cell adhesion molecule-1 ) and integrin aM ( CD11b ) were also determined. RESULTS: Lipopolysaccharide (LPS)-activated HMVEC damage and PMN respiratory burst depend on the presence of PMP and the concentration of sCD40L. PMP -induced PMN-mediated HMVEC damage was significantly reduced by human2824 -treated PMNs (p < 0.05). The surface expression of ICAM-1, CD54, intercellular cell adhesion molecule-1 on HMVEC was increased by LPS stimulation. The expression of CD11b on PMNs was increased by PMP priming. Blocking ICAM-1, CD54, intercellular cell adhesion molecule-1 with a monoclonal antibody (MoAb) ICAM-1, CD54, intercellular cell adhesion molecule-1 significantly reduced HMVEC damage (p < 0.05). The treatment of endothelial cells but not PMN with a MoAb targeting CD40 failed to prevent the HMVEC damage caused by PMPs (p > 0.05). CONCLUSION: PMPs carry a concentrated human1603 signal, promote PMN-mediated HMVEC damage , and may affect the development of transfusion-related acute lung injury .
| null |
4883_biomrc
|
Title: XXXX in an Afro-Caribbean population: a review of demographic and clinical features.
OBJECTIVE: To assess the clinical and selected demographic features of patients with SS, systemic sclerosis ( SS, systemic sclerosis ) seen over a 10-year period at the Rheumatology service of the Queen Elizabeth Hospital, Barbados. To compare these data with what is known to obtain in other ethnic populations. DESIGN AND METHODS: A chart review involving all patients who were found to have SS, systemic sclerosis based on the American College of Rheumatology clinical criteria was conducted between 1996 and 2006. RESULTS: Twenty-seven patients with SS, systemic sclerosis were identified in this predominantly Afro-Caribbean population. The prevalent and incident cases numbered 10 and 17 respectively. Twenty-six of these patients were female and the mean age at diagnosis was 37.3 years. Diffuse cutaneous involvement was seen in 63% of cases and limited cutaneous involvement in 37%. The most common clinical features in descending order of frequency were "Raynauds phenomenon" , gastroesophageal reflux , pigmentary skin changes, digital pitting/ulceration, telangiectasia, Telangiectasia and pulmonary disease . CONCLUSION: In a predominantly Afro-Caribbean population, SS, systemic sclerosis was uncommonly seen, had a marked female preponderance and an earlier age of onset than that seen in Caucasian populations. As expected, diffuse disease was the more common subtype and digital pitting, pigmentary skin changes, and pulmonary disease were amongst the most frequent clinical features. telangiectasia, Telangiectasia were found more frequently than the literature suggests is typical for patients of African descent.
| null |
2837_biomrc
|
Title: [ XXXX in @entity1201 : experience of National @entity1201 Center in Casablanca].
ulcerative and vegetative tumor28 is a late complication of women, patients, patient, men411 in women, patients, patient, men201 . The objective of this study is to describe and analyze the epidemiological, clinical, and therapeutic aspects of this complication in Morocco. A retrospective study was conducted from January 2000 to December 2009 at the National Center of women, patients, patient, men201 . All our women, patients, patient, men had a histological confirmation. Ten women, patients, patient, men were included in this study. There were seven women, patients, patient, men and three women, patients, patient, men , with a mean age of 58.8 years. Six women, patients, patient, men had a multibacillary form of women, patients, patient, men201 and four had a paucibacillary form. The average duration of women, patients, patient, men411 was 34.4 years. Clinical appearance at diagnosis was an ulcerative and vegetative tumor . Treatment was by radical amputation. Evolution was marked by metastatic spread in six women, patients, patient, men . One women, patients, patient, men died of disseminated disease. In Morocco, women, patients, patient, men201 has been on the decline since 1990, but the occurrence of late complications in the women, patients, patient, men201 women, patients, patient, men as women, patients, patient, men89 persists. Prevention of these complications should be part of the national fight against women, patients, patient, men201 .
| null |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.