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792_biomrc
|
Title: Opportunistic Screening for XXXX and Selected Cardiovascular Risk Factors among Adults Attending a Primary Health Center in Puducherry, India.
BACKGROUND: India is currently suffering from an epidemic of noncommunicable diseases; it is thus imperative to screen for cardiovascular risk factors in participants, women, Patients, patients, people, persons visiting Primary Health Centers (PHCs). The objective of the study was to measure the amount of undiagnosed participants, women, Patients, patients, people, persons01 and selected cardiovascular risk factors present among the adult population through opportunistic screening at the PHC. METHODS: A facility-based opportunistic screening program was carried out in a PHC in rural Puducherry. participants, women, Patients, patients, people, persons and accompanying participants, women, Patients, patients, people, persons aged 30 years and above, who attended the daily outpatient department (OPD) were included. The OPD provides outpatient services and medical procedures or tests without requirement of an overnight stay, and functions for 4 h a day. Known participants, women, Patients, patients, people, persons01 participants, women, Patients, patients, people, persons and pregnant participants, women, Patients, patients, people, persons were excluded. Information on age, gender, diabetes status, and personal history of tobacco and alcohol use were collected using an interview schedule. Height, weight and waist circumference were measured, along with blood pressure and blood sugar using standard protocols. Systolic blood pressure (SBP) >= 140 and/or diastolic blood pressure (DBP) >= 90 mm Hg was taken as participants, women, Patients, patients, people, persons01 . SBP of 120-139 mm Hg and/or DBP of 80-89 mm Hg were taken as participants, women, Patients, patients, people, persons556 . RESULTS: A total of 324 participants, women, Patients, patients, people, persons were screened; 56.8% were females. The mean standard deviation (SD) age of the participants, women, Patients, patients, people, persons was 47.7 (SD 12.6) years. participants, women, Patients, patients, people, persons01 and participants, women, Patients, patients, people, persons556 were present in 17.9% and 37.7% of the participants, women, Patients, patients, people, persons respectively. 17.3% participants, women, Patients, patients, people, persons had diabetes . 22.2% and 21.3% of all participants, women, Patients, patients, people, persons were current users of tobacco and alcohol respectively. Generalized obesity was present in 31.8% of the participants, women, Patients, patients, people, persons ; 19.1% were overweight. 45.1% participants, women, Patients, patients, people, persons had participants, women, Patients, patients, people, persons144 . CONCLUSIONS: A relatively large proportion of adults were found to have participants, women, Patients, patients, people, persons556 and obesity , thus showing the need for early intervention.
| null |
4889_biomrc
|
Title: Heparins attenuated histone-mediated XXXX in vitro and improved the survival in a @entity35 model of histone-induced @entity881 .
BACKGROUND: The beneficial effects of heparin in the treatment of severe sepsis , septic shock , and sepsis -associated disseminated intravascular coagulation (DIC) have recently been reported. However, the mechanisms underlying the therapeutic benefits of heparin in these conditions have not yet been clearly elucidated. The purpose of this study was to confirm the effect of heparin of neutralizing histone patients37 . METHODS: Rat models of histone H3-induced hepatic and renal dysfunction81 were administered in a low or high dose of unfractionated heparin (UFH), low-molecular-weight heparin (LMWH), or argatroban , and the therapeutic effects of each anticoagulant were examined. In another series, the survival of the histone H3-administered animals was evaluated. Furthermore, the effect of each of the aforementioned anticoagulants on cell death induced by histone H3 was examined in cultured vascular endothelial cells and leukocytes. RESULTS: Although UFH, LMWH, and argatroban significantly suppressed the histone-induced decrease of the WBC and platelet counts in the animal models of hepatic and renal dysfunction81 , only UFH and LMWH attenuated hepatic and renal dysfunction . In addition, the mortality was significantly reduced only by high-dose UFH and LMWH. The in vitro study revealed that both vascular endothelial cell death and leukocyte cell death were significantly attenuated by UFH and LMWH but not by argatroban . CONCLUSIONS: The histone-neutralizing effect of heparin may contribute to the beneficial effects of heparins observed in the animal study. The results of the in vitro study further confirmed the above contention and suggested that heparin binds to histones to attenuate the cytotoxic actions of the latter. Since heparin has been demonstrated to protect animals from the organ damage induced by histones and consequently reduce the mortality, administration of heparin could become a treatment of choice for patients suffering from severe sepsis .
| null |
793_biomrc
|
Title: Insights into endosomal maturation of XXXX holo- @entity69 in the enteric parasite @entity2330 : essential roles of @entity27341 and @entity4814 in biogenesis of giant early endocytic vacuoles.
UNASSIGNED: The pathogenic amoeba Entamoeba histolytica is one of the causative agents of health hazards in tropical countries. It causes mammalian, human6126 , mammalian, human960 and liver abscesses in mammalian, human . iron, Iron is one of the essential nutritional resources for survival and chronic infection caused by the amoeba. The parasite has developed multiple ways to import, sequester and utilize iron, Iron from various iron, Iron -binding proteins from its host. In spite of its central role in pathogenesis, the mechanism of iron, Iron uptake by the parasite is largely unknown. Here, we carried out a systematic study to understand the role of some of the amoebic homologues of mammalian, human endocytic Rab GTPases ( Rab5 and Rab21 , Rab7A and Rab7B ) in intracellular transport of mammalian, human holo- transferrin by the parasite. Flow cytometry and quantitative microscopic image analysis revealed that Rab5 and Rab7A are required for the biogenesis of amoebic giant endocytic vacuoles (GEVs) and regulate the early phase of intracellular trafficking of transferrin . Rab7B is involved in the late phase, leading to the degradation of transferrin in the amoebic lysosome-like compartments. Using time-lapse fluorescence imaging in fixed trophozoites, we determined the kinetics of the vesicular transport of transferrin through Rab5 -, Rab7A - and Rab7B -positive compartments. The involvement of Rab7A in the early phase of endocytosis by the parasite marks a significant divergence from its host in terms of spatiotemporal regulation by the Rab GTPases.
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2844_biomrc
|
Title: @entity1653 : A rare type of XXXX .
UNASSIGNED: Introduction. patients653 are rare and preoperative diagnosis is difficult. The present study was performed to assess the clinical and radiological outcome of patients653 . Methods. We performed a retrospective analysis of 13 patients (mean age: 49.9 years) who underwent surgical resection of patients653 from January 2006 to February 2014. There were 5 male and 8 female patients . The Glasgow Outcome Scale was used to assess the clinical outcome at 6 months. Results. patients0 was the main presenting clinical feature. Most of the tumours were located on the right side. The frontal convexity was the most common site. Gross total resection was performed in 10 patients . The most common histopathological type was meningothelial variety. Conclusion. patients653 are usually benign that occur in relatively young patients . Resection of cysts that show contrast enhancement is essential to reduce recurrence.
| null |
2848_biomrc
|
Title: Inhibition of the @entity908 kinase reaction decreases the contractile reserve of isolated XXXX hearts.
To define the relation between phosphoryl transfer via creatine kinase (CK) and the ability of the intact beating heart to do work, we chemically inhibited CK activity and then measured cardiac performance under physiological and acute stress conditions. Isolated perfused rat hearts were exposed to iodoacetamide (IA) and subjected to one of three cardiac stresses: hypercalcemic ( Ca2+ = 3 mM) buffer perfusion (n = 7), norepinephrine (2 mumol/min) infusion (n = 6), or hypoxic, hypoxia buffer perfusion (n = 5). IA decreased CK activity to near zero, measured in intact hearts by 31P magnetization transfer, and to 2% of control CK activity, measured in myocardial homogenates. The CK isoenzyme profile was unchanged, suggesting nonselective IA inhibition of all isoenzymes. Mitochondria isolated from IA-treated hearts had normal ADP :O ratios, state 3 respiratory rates, and unchanged acceptor and respiratory control ratios. Neither actomyosin adenosinetriphosphatase nor adenylate kinase activities were changed. After IA exposure, end-diastolic pressure, left ventricular developed pressure, and heart rate were unchanged for at least 30 min at physiological perfusion pressures, but large changes were observed during stress conditions. The increase in left ventricular developed pressure induced by hypercalcemic perfusion and by norepinephrine infusion decreased by 39 and 54%, respectively. During hypoxic, hypoxia , the rate of phosphocreatine depletion was decreased by 57%, left ventricular developed pressure declined, and end-diastolic pressure increased faster than in controls. These results show that inhibition of CK to < 2% of control activity by IA reduced contractile reserve by approximately 50%. We conclude that CK activity is essential for the expression of the full dynamic range of myocardial performance.
| null |
4899_biomrc
|
Title: Robotic-assisted pelvic lymph node dissection for XXXX : frequency of nodal metastases and oncological outcomes.
PURPOSE: Limited data are available regarding the oncologic efficacy of pelvic lymph node dissection (PLND) performed during robotic-assisted laparoscopic prostatectomy (RALP) for prostate cancer . We aimed to determine the frequency of pelvic lymph node metastasis and oncological outcomes following RALP with PLND in Patients, patients, men who did not receive adjuvant androgen deprivation therapy (ADT). METHODS: We retrospectively reviewed the records of 1740 consecutive Patients, patients, men who underwent RALP and extended PLND. The primary endpoint was biochemical recurrence (BCR). The estimated BCR probability was obtained using the Kaplan-Meier method. Cox proportional hazard regression models were used to assess for predictors of BCR. RESULTS: One hundred and eight Patients, patients, men (6 %) with positive LNs were identified. The median number of LNs removed was 17 (IQR 11-24), and median follow-up was 26 months (IQR 14-43). Ninety-one (84 %) Patients, patients, men did not receive adjuvant ADT of whom 60 % had BCR with a median time to recurrence of 8 months. The 1- and 3-year BCR-free probability was 42 and 28 %, respectively. Patients, patients, men with <=2 LN+ had significantly better biochemical-free estimated probability compared to those with >2 LN+ (p = 0.002). The total number of LN+ (HR = 1.1; 95 % CI 1.01-1.2, p = 0.04) and Gleason 8-10 (HR = 1.96; 95 % CI 1.1-3.4, p = 0.02) were predictors of BCR on multivariate analysis. CONCLUSION: Among Patients, patients, men with positive lymph nodes at time of robotic prostatectomy, those with two or fewer positive nodes and Gleason <8 exhibited favorable biochemical-free survival without adjuvant therapy.
| null |
2853_biomrc
|
Title: Deactivation of macrophages by XXXX .
Macrophage activation--enhanced capacity to kill, in a cell that otherwise mostly scavenges--is essential for host survival from infection and contributes to containment of tumours, tumour . Both microbes and tumours, tumour cells, therefore, may be under pressure to inhibit or reverse the activation of macrophages. This reasoning led to the demonstration of macrophage deactivating factors from both microbes and tumours, tumour cells. In some circumstances the host itself probably requires the ability to deactivate macrophages. Macrophages are essential to the healing of wounds and repair of tissues damaged by inflammation . Yet the cytotoxic products of the activated macrophages can damage endothelium, fibroblasts, smooth muscle and parenchymal cells (reviewed in ref. 6). Thus, after an inflammatory site has been sterilized, the impact of macrophage activation on the host might shift from benefit to detriment. These concepts led us to search for macrophage deactivating effects among polypeptide growth factors that regulate angiogenesis, fibrogenesis and other aspects of tissue repair. Among 11 such factors, two proteins that are 71% similar proved to be potent macrophage deactivators: these are transforming growth factor-beta 1, TGF-beta 1 ( transforming growth factor-beta 1, TGF-beta 1 ) and TGF-beta 2 .
| null |
806_biomrc
|
Title: [Risk of thrombosis in XXXX . A review with new results of studies].
Malignomas of the uterus predispose to patients031 . Local application of radium increases the activation of hemostasis. In newer examinations there are hints, that impairment to thrombocyte function and Prostacyclin, prostacyclin metabolism may have a pathogenetic meaning. Thrombocyte aggregation and Prostacyclin, prostacyclin sensitivity of thrombocytes have been examined in two groups of patients : 21 patients following hysterectomy because of endometrium cancer stage I, treated with one vaginal application for the vaginal cuff and 10 patients with cervical carcinoma Stage IIa-IIIb treated combined intrauterine-intravaginally. The first group was prophylactically treated with low-dose-heparin, the second one with patients1271 (Sintrom). A slight, but significant increase of thrombocyte aggregation by 4.8 per cent respectively 5.0 per cent could be observed in both groups. Prostacyclin, prostacyclin sensitivity of thrombocytes (PST) was significantly reduced by 20 per cent before irradiation in all patients compared with patients without patients89 . In cases of intravaginal radium application we saw immediately after removal of the radioactive source a further reduction of PST by 12.5 per cent. 24 hours later a significant decrease of PST by 18.5 per cent could be observed. Contrary to this no significant changes were induced by combined intrauterine and intravaginal radium insertion. Therefore reduction of PST may be interpreted as a possible change of thrombocyte function in vivo caused by irradiation. It may be likely that these disturbances of thrombocyte function combined with radiogenic vessel wall damages and plasmatic hypercoagulability are responsible for the high thromboembolic risk of radium therapy. These patients should be treated prophylactically. Probably the efficiency of this prophylaxis can be improved by additional application of selective inhibitors of thrombocyte aggregation or inductors of Prostacyclin, prostacyclin synthesis.
| null |
2855_biomrc
|
Title: Specific members of the predominant gut microbiota predict XXXX following colectomy and IPAA in UC.
OBJECTIVE: Pouchitis, pouchitis is the most common complication after colectomy with ileal pouch-anal anastomosis (IPAA) for UC and the risk is the highest within the 1st year after surgery. The pathogenesis is not completely understood but clinical response to antibiotics suggests a role for gut microbiota. We hypothesised that the risk for Pouchitis, pouchitis can be predicted based on the faecal microbial composition before colectomy. DESIGN: Faecal samples from 21 patients with UC undergoing IPAA were prospectively collected before colectomy and at predefined clinical visits at 1 month, 3 months, 6 months and 12 months after IPAA. The predominant microbiota was analysed using community profiling with denaturing gradient gel electrophoresis followed by quantitative real-time PCR validation. RESULTS: Cluster analysis before colectomy distinguished patients with Pouchitis, pouchitis from those with normal pouch during the 1st year of follow-up. In patients developing Pouchitis, pouchitis , an increase of Ruminococcus gnavus (p<0.001), B. vulgatus, Bacteroides vulgatus (p=0.043), C. perfringens, Clostridium perfringens (p=0.011) and a reduction of two Lachnospiraceae genera (Blautia (p=0.04), Roseburia (p=0.008)) was observed. A score combining these five bacterial risk factors was calculated and presence of at least two risk factors showed a sensitivity and specificity of 100% and 63.6%, respectively. CONCLUSIONS: Presence of R. gnavus, B. vulgatus, Bacteroides vulgatus and C. perfringens, Clostridium perfringens and absence of Blautia and Roseburia in faecal samples of patients with UC before surgery is associated with a higher risk of Pouchitis, pouchitis after IPAA. Our findings suggest new predictive and therapeutic strategies in patients undergoing colectomy with IPAA.
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812_biomrc
|
Title: Symptom clusters in traumatic XXXX : an exploratory literature review.
patient, persons118 , spasticity , and depression are three common secondary health problems experienced by patient, persons living with traumatic patient, persons566 . Limited research exists related to the interaction of these symptoms and their cumulative effect on patient, persons outcomes and quality of life. This article is a report of an exploratory literature review that uses the conceptual approach of symptom clustering to classify secondary health problems in patient, persons566 . CINAHL, MEDLINE, and PsycINFO databases were searched for studies published in English between 1990 and 2008. Eleven articles met the inclusion criteria for review. Studies were categorized by levels of evidence defined by the American Association of Neuroscience Nurses Clinical Practice Guidelines. Research on the interaction of the symptom pair chronic patient, persons58 and depression was evident. Several surveys reported the occurrence of multiple symptoms, but none specifically addressed the management of the interactive effects of the symptom cluster chronic patient, persons58 , spasticity , and depression . Increased disciplinary knowledge of symptom clusters in the patient, persons566 population is needed for research and practice. Furthermore, determining symptom clusters in this population may assist clinicians in providing targeted interventions to simultaneously treat multiple symptoms.
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4910_biomrc
|
Title: Should English healthcare providers be penalised for failing to collect XXXX -reported outcome measures? A retrospective analysis.
OBJECTIVE: The best practice tariff for hip and knee replacement in the English NHS, National Health Service ( NHS, National Health Service ) rewards providers based on improvements in patients, patient, PARTICIPANTS -reported outcome measures (PROMs) collected before and after surgery. Providers only receive a bonus if at least 50% of their patients, patient, PARTICIPANTS complete the preoperative questionnaire. We determined how many providers failed to meet this threshold prior to the policy introduction and assessed longitudinal stability of participation rates. DESIGN: Retrospective observational study using data from Hospital Episode Statistics and the national PROM programme from April 2009 to March 2012. We calculated participation rates based on either (a) all PROM records or (b) only those that could be linked to inpatient records; constructed confidence intervals around rates to account for sampling variation; applied precision weighting to allow for volume; and applied risk adjustment. SETTING: NHS, National Health Service hospitals and private providers in England. patients, patient, PARTICIPANTS : NHS, National Health Service patients, patient, PARTICIPANTS undergoing elective unilateral hip and knee replacement surgery. MAIN OUTCOME MEASURES: Number of providers with participation rates statistically significantly below 50%. RESULTS: Crude rates identified many providers that failed to achieve the 50% threshold but there were substantially fewer after adjusting for uncertainty and precision. While important, risk adjustment required restricting the analysis to linked data. Year-on-year correlation between provider participation rates was moderate. CONCLUSIONS: Participation rates have improved over time and only a small number of providers now fall below the threshold, but administering preoperative questionnaires remains problematic in some providers. We recommend that participation rates are based on linked data and take into account sampling variation.
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2863_biomrc
|
Title: Relative validation of 24-h urinary XXXX excretion as a biomarker for dietary @entity3096 intake from fruit and vegetables in healthy adolescents.
PURPOSE: A biomarker for dietary flavonoid intake from fruit and vegetables (FlavFV) is needed to elucidate the relevance of flavonoids from these sources for the prevention of chronic diseases . Urinary hippuric acid (HA)-a major metabolite of flavonoids -is promising in this respect as it was shown to satisfyingly indicate fruit and vegetable consumption in different age groups. Therefore, we validated urinary HA as a biomarker for intake of FlavFV. METHODS: Analyses included data from 287 healthy adolescents of the DONALD Study (aged 9-16 years) for whom a minimum of two pairs of HA measurements from 24-h urine samples (test method) and FlavFV intake estimated from 3-day weighed dietary records (reference method) existed. Agreement between both methods was assessed by Spearman correlation and cross-classification analyses. Possible confounders of the association were identified by linear regression models. Analyses were performed using a split-sample approach allowing for consecutive exploration (n = 192) and confirmation (n = 95) of results. RESULTS: Agreement between urinary HA excretion and FlavFV intake was moderate according to correlation analysis in the exploratory sample (r unadjusted = 0.47, P < 0.0001). Yet, 79 % of the subjects were classified into same/adjacent quartiles, and only 5 % were misclassified into opposite quartiles. These findings were corroborated by analyses in the confirmatory sample (r unadjusted = 0.64; 88 % in same/adjacent vs. 4 % in opposite quartiles). Body surface area (BSA) was the only relevant covariate in the exploratory sample, and its adjustment improved cross-classification estimates in both subsamples. CONCLUSIONS: BSA-adjusted 24-h urinary HA excretion represents a suitable biomarker of habitual FlavFV intake in healthy adolescents.
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4918_biomrc
|
Title: Effectiveness of @entity227 for convergence dysfunctions and long-term stability after XXXX .
BACKGROUND: Symptomatic children, patients319 ( children, patients319 ) is a common binocular dysfunction . It is often associated with children, patients887 ( children, patients887 ). Optimum therapy for this condition was recently shown to be in-clinic vision therapy, VT ( vision therapy, VT ). More scientific studies are needed to assess the effectiveness of vision therapy, VT and verify these evidence-based results. METHODS: Fifty-seven children, patients aged 9-13 years were diagnosed with symptomatic children, patients319 (n = 27) or combined symptomatic children, patients319 and children, patients887 (n = 30). They were independently divided into a treatment and a control group, matched by age and gender. The treatment group received 12 weeks of vision therapy, VT while the control group received no therapy. A quality of life instrument documented the symptomatic children, patients and charted improvement in symptoms after therapy. Clinical aspects were also assessed to determine the treatment effects on clinical findings. Twenty children, patients in the treatment group completed a 1 year follow-up examination. RESULTS: Symptom scores and clinical measures of the treatment and control groups were not significantly different at baseline (p > 0.05), but showed significant differences after completion of 12 weeks of treatment (p < 0.001). No significant changes of either symptoms or signs were evident for the control group. One year follow-up examination revealed that most children, patients maintained the improved symptom and clinical measures after vision therapy, VT . CONCLUSION: This study supports the notion that vision therapy, VT is a successful method of treating children, patients319 and children, patients319 combined with children, patients887 .
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823_biomrc
|
Title: [Observation on natural killer cell activity in @entity356 XXXX and effect of nonspecific immunopotentiator administration on its postoperative reduction].
Natural killer cell (NK) activity, together with various nonspecific immunologic parameters, was measured preoperatively, and its changes induced by operative stress were examined in metastasis56 patients . Effect of administration of a nonspecific immunopotentiator, patients012 , was evaluated by postoperative changes in NK activity. Peripheral blood NK activity was measured by 51Cr-release assay against K-562 target cells. It was found that NK activity in the metastasis56 patients was significantly lower than that in healthy subjects. The reduction was specially marked in the cases of cancer at stages I and IV. NK activity in the cases with hepatic or peritoneal metastasis was significantly lower than that in the cases without such metastasis . NK activity in the cases of noncurative gastric resection or non-resection was significantly lower than that in the cases of curative gastric resection. NK activity in the cases of stage IV and "por" in histology was significantly lower than that in the cases of stage IV and "tub1" in histology. In the cases at stages I + II, there was a positive correlation between NK activity and IgG FcR(+) T cell ratio. There was a negative correlation between NK activity and alpha 2-globulin ratio and the correlation was especially significant in the cases at stages III + IV. In the cases at stages III + IV, receiving administration of patients012 only postoperatively, NK activity was significantly reduced or tended to be reduced at 1 through 4 week(s) postoperatively, while such a reduction was not seen in the cases receiving administration of patients012 pre- and postoperatively. This phenomenon was more marked in the cases showing a serum albumin level lower than 3.5 g/dl or in the cases undergoing operations longer than 4 hours in duration.
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2872_biomrc
|
Title: Prospective surgical outcome study of relief of symptoms following surgery in @entity1 with XXXX .
Many of the symptoms experienced by patients with primary hyperparathyroidism ( HPT ) develop insidiously and have often been misinterpreted as normal aging. The purpose of this study was to quantify HPT patients ' preoperative symptoms prospectively and study the impact of successful surgical intervention on these symptoms. Altogether 63 consecutive patients with primary HPT and 54 comparison patients with nontoxic patients374 were prospectively enrolled in the study. An outcome questionnaire documenting symptoms with a visual analog scale (VAS) was used. The questionnaire was filled out preoperatively and at 7 to 10 days and 3 and 12 months postoperatively. At 1 year the questionnaire also included a general health assessment and quality of life index. Demographic data and follow-up blood work was obtained. Descriptive statistics, parametric comparisons (t-tests, ANOVA), and nonparametric comparisons (Mann-Whitney U-test) were calculated. The HPT group demonstrated a significant decrease in reported symptoms between the preoperatively assessment and 7 to 10 days after operation (p < 0.001). There were no further statistically significant decreases in the HPT group's symptoms at 3 and 12 months, but there was a trend for these symptoms to decrease over time. HPT patients perceived a 60% increase in their general health at 1 year; the comparison group perceived no increase. There was no significant change in the symptoms reported by the comparison group between each of the study intervals. Surgical intervention on HPT patients significantly reduces preoperative symptoms, and this reduction is most marked within the first 10 days after surgery.
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2876_biomrc
|
Title: Incidence of local complications after intramedullary nailing and after plate fixation of femoral shaft XXXX .
A consecutive series of 378 patients with 381 acute adult femoral shaft patients74 in previously intact femora admitted during a 10-year period was reviewed for the incidence of local complications including malunion. The majority, 282 patients74 (74%), were caused by motor vehicle accidents. The median age of the patients was 28 years. The policy of management was internal fixation of the patients74 on the day of admission. The method of treatment was intramedullary nailing (K ntscher or interlocking nailing) in 279 and plate fixation in 102 patients74 . A local complication occurred in 90 patients (24%). Of these 90 cases 24 had malunion only while in the remaining 66 patients there was mechanical failure of fixation in 27, local infection in 20 (5.3% of the total), delayed union or nonunion in 15, and refracture in four patients . Concurrent injuries in the lower extremities were associated with a significantly increased frequency of delayed union, nonunion, and refracture. In 41 patients (11%) a total of 58 reoperations had to be undertaken because of local complications. There was an over-representation of plated patients74 among those patients suffering a local complication classified as severe, 24 out of 37 (chi 2 = 30.3; p less than 0.001). Consequently, we now only exceptionally use plate fixation in the management of femoral shaft patients74 .
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2879_biomrc
|
Title: The importance of defining left ventricular area at risk in vivo during acute XXXX : an experimental evaluation with myocardial contrast two-dimensional echocardiography.
Because the left ventricular "area at risk" is the most important determinant of ultimate infarct size, it would be useful to know the size of the area at risk during acute myocardial infarction to make therapeutic decisions. We therefore performed a series of experiments in four groups of dogs . In group I dogs (n = 15) we attempted to determine whether current methods of assessing left ventricular function during acute myocardial infarction reflect the true size of the area at risk. At each of two to five sequential stages, a more proximal coronary occlusion was performed to produce a larger area at risk until cardiovascular collapse occurred. At each stage, the area at risk (measured by myocardial contrast echocardiography), hemodynamic variables, and left ventricular ejection fraction (LVEF) were measured. Hemodynamic variables became abnormal when the area at risk was large (25% to 40% of the left ventricle), whereas LVEF became abnormal when the area at risk was of moderate size (18%). When cardiac output and LVEF were normalized to baseline values, a close inverse relationship was noted between these variables and area at risk. In contrast, there was a poor relationship between normalized mean arterial pressure and area at risk (r = .42). In group II dogs (n = 9) the area at risk was measured serially over 6 hr after coronary occlusion . The size of the area at risk remained unchanged regardless of the transmural extent of the ultimate infarct . The circumferential endocardial extent of the area at risk closely predicted the circumferential endocardial extent of the infarct at 6 hr in eight of nine dogs that developed an infarct . Group III dogs (n = 7) underwent the same protocol as group II dogs , but the duration of occlusion was 3 hr. The circumferential endocardial extent of the area at risk closely predicted the circumferential endocardial extent of the infarct . Group IV dogs (n = 5) underwent subtotal coronary occlusion . Although regional wall motion abnormalities were noted in this group, no area at risk could be defined. We conclude that although a close inverse relationship is noted between normalized cardiac output and area at risk, the absolute values for cardiac output and other hemodynamic variables become abnormal only when the area at risk is large (25% to 40%); measurement of LVEF may provide a better assessment of the size of the area at risk than hemodynamic variables.(ABSTRACT TRUNCATED AT 400 WORDS)
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2880_biomrc
|
Title: XXXX related to surfing.
BACKGROUND: Surfing is a popular sport in coastal areas, which can be associated with Chest injuries, chest injuries . METHODS: Between 2008 and 2013, 6 patients, patient, Patient were referred to our hospital with Chest injuries, chest injuries sustained during surfing. Clinical data were collected from their medical records and analyzed retrospectively. RESULTS: patients, patient, Patient age ranged from 35 to 52 years. Five of the 6 patients, patient, Patient were male. Four patients, patient, Patient were injured in August, and the other two were injured in September and October. Rib fractures were observed in 3 of the 6 patients, patient, Patient . The other 3 patients, patient, Patient were diagnosed with chest contusions only. Hemothorax occurred in one patients, patient, Patient . No lacerations were observed in any of the 6 patients, patient, Patient . CONCLUSION: Chest injuries, chest injuries associated with surfing are usually blunt Chest injuries, chest injuries ; however, they may occasionally be life-threatening.
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4928_biomrc
|
Title: Effects of heparin fractions on the prevention of @entity39 resulting from XXXX extravasation: an experimental study.
Extravasation of a chemotherapeutic agent is one of the most frequent complications in cancer patients . Full-thickness skin necrosis often occurs after extravasation. Alternative approaches to treatment are local wound care, elevation, and hypothermia . It was shown that heparin prevents skin necrosis . In this experimental study, the effects of heparin fractions on the prevention of skin necrosis were compared by applying an extravasation model of Adriamycin, doxorubicin hydrochloride in rats . Forty Sprague-Dawley male rats weighing 250 to 300 g were used. A total of 0.3 ml Adriamycin, doxorubicin hydrochloride was administered subcutaneously to all rats . Ten minutes later, in the control group (group I), 1 ml normal saline was administered subcutaneously. In the first experimental group (group II), 100 U per day heparin patients372 was administered in a volume of 1 ml subcutaneously. In the second experimental group (group III), nadroparin calcium (5 anti-Xa U per kilogram per day) was administered. In the third and last experimental group (group IV), patients6960 (5 anti-Xa U per kilogram per day) was administered. All drugs were administered for 2 weeks. Necrotic areas were measured 4 weeks later. Statistical analysis was performed using the Kruskal-Wallis analysis of variance and the Mann-Whitney test. Heparin fractions caused a decreased patients066 rate and size than controls ( < 0.05). There was no superiority among heparin fractions. The authors think that low-molecular weight heparins are preferred, considering the higher risk of bleeding with unfractionated heparin.
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834_biomrc
|
Title: Inhibition of Peripheral Nerve Scarring by @entity460 Antagonists, Also Known as XXXX Channel Blockers.
UNASSIGNED: The aim of this research was to investigate the impact of calcium channel blockers ( verapamil ) on the formation of scars in the sciatic nerve anastomosis after peripheral nerve injury . One hundred twenty healthy, male Sprague-Dawley rats were selected and prepared with right sciatic nerve injury for this study. Samples were selected at the fourth and 12th weeks, respectively, after treatment and observations were made on the nerve anastomosis healing and diameter. Image analysis and statistical processing were carried out relating to the results of the study. The diameter of the anastomosis of the treatment group at weeks 4 and 12 was noticeably smaller than the control group (P < 0.05). In the treatment group at week 4, there were many vesicles observed in the fibroblasts' cytosol and in the control group, the fibroblasts exhibited high number of rough endoplasmic reticulum. The collagen content of the nerve scarring at week 12 in the treatment group was apparently less than the control group (P < 0.01). The calcium channel blocker ( verapamil ) reduced the axon resistance through the anastomosis during nerve regeneration. It can effectively inhibit the formation of scarring from nerve injury . It also provided an excellent microenvironment for the regeneration of nerve fibers.
| null |
4931_biomrc
|
Title: Substaging of Lymph Node Status in Resected XXXX Has Strong Prognostic Correlations: Proposal for a Revised N Classification for TNM Staging.
BACKGROUND: The current tumor -node- metastasis staging system for the pancreas does not incorporate the number of lymph nodes (LNs) with metastasis . METHODS: Among 1649 pancreaticoduodenectomies, 227 stringently defined PDACs, pancreatic ductal adenocarcinomas ( PDACs, pancreatic ductal adenocarcinomas ) that had undergone a specific approach of LN harvesting were analyzed for the prognostic value of LN substaging protocols used for other gastrointestinal (GI) organs. RESULTS: The median number of LNs harvested was 18, and the median number of LNs with metastasis was 3. Lymph node metastasis was detected in 175 cases (77 %). The number of LNs involved correlated significantly with clinical outcome. When cases were substaged with the protocol already in use for the upper GI organs (N0: no metastasis , N1: metastasis to 1-2 LNs; N2: metastasis to >= 3 LNs), the median overall survival times were 35, 21, and 18 months, and the respective 3-year survival rates were 46, 34, and 20 % (p = 0.004). Analysis of the Surveillance, Epidemiology and End Results (SEER) database also confirmed the survival differences between these substages (median overall survival times of 23, 15, and 14 months and respective 3-year survival rates of 37, 22, and 18 %; p < 0.0001). The substaging protocol for the lower GI organs (N0: no metastasis ; N1: metastasis to 1-3 LNs; N2: metastasis to >= 4 LNs) also was significant, with median overall survival times of 35, 21, 18 months and respective 3-year survival rates of 46, 26, and 23 %; p = 0.009). The association between higher N stage and shorter survival persisted with multivariate modeling for both protocols, although the prognostic value of the upper GI protocol appeared to be slightly stronger according to the Akaike Information Criterion method. CONCLUSION: In conclusion, with proper LN harvesting, the LN metastasis rate in PDACs, pancreatic ductal adenocarcinomas is very high (77 %). Substaging of LN metastasis has significant prognostic value and needs to be considered in the N staging of PDACs, pancreatic ductal adenocarcinomas . The protocol already in use for other upper GI tract organs, which currently also is proven significant for ampulla, would be preferable, although the lower GI tract protocol also is applicable.
| null |
838_biomrc
|
Title: Thoracoscopic repair of XXXX with a distal fistula - lessons from the first 10 operations.
INTRODUCTION: children, patients, boys, patient, girls152 ( children, patients, boys, patient, girls152 ) repair was first performed in 1999, but still the technique is treated as one of the most complex pediatric surgical procedures. AIM: The study presents a single-center experience and learning curve of thoracoscopic repair of children, patients, boys, patient, girls152 and children, patients, boys, patient, girls727 . MATERIAL AND METHODS: From 2012 to 2014, 10 consecutive children, patients, boys, patient, girls with children, patients, boys, patient, girls152 and children, patients, boys, patient, girls727 were treated thoracoscopically in our center. There were 8 children, patients, boys, patient, girls and 2 children, patients, boys, patient, girls . Mean gestational age was 36.5 weeks and mean weight was 2230 g. Four children, patients, boys, patient, girls had associated anomalies. The surgery was performed after stabilization of the children, patients, boys, patient, girls between the first and fourth day after birth. Five children, patients, boys, patient, girls required intubation before surgery for respiratory distress. Bronchoscopy was not performed before the operation. RESULTS: In 8 children, patients, boys, patient, girls , the endoscopic approach was successfully used thoracoscopically, while in 2 children, patients, boys, patient, girls conversion to an open thoracotomy was necessary. In all children, patients, boys, patient, girls except 1, the anastomosis was patent, with no evidence of leak. One children, patients, boys, patient, girls demonstrated a leak, which did not resolve spontaneously, necessitating surgical repair. In long-term follow-up, 1 children, patients, boys, patient, girls required esophageal dilatation of the anastomosis . All children, patients, boys, patient, girls are on full oral feeding. CONCLUSIONS: The endoscopic approach is the method of choice for the treatment of children, patients, boys, patient, girls152 in our center because of excellent visualization and precise atraumatic preparation even in neonates below a weight of 2000 g.
| null |
4936_biomrc
|
Title: Vaginal sacrospinous colpopexy and perineorrhaphy for XXXX : preliminary report.
OBJECTIVE: To review our experience with vaginal sacrospinous colpopexy combined with perineorraphy performed for patients, patient with genital prolapse who concomitantly suffered from faecal incontinence, FI ( faecal incontinence, FI ). SETTING: Gynaecology Department, Benenden Hospital, Benenden, Kent, UK. SUBJECTS AND METHODS: Between January 1997 and December 2001, 16 patients, patient presented with symptoms of genital prolapse and faecal incontinence, FI . Eleven out of the 16 patients, patient (69%) had anorectal physiological tests and endoanal ultrasound performed before surgery. All patients, patient had sacrospinous colpopexy and perineorraphy. Simultaneous vaginal hysterectomy was performed in two patients, patient and anterior colporrhaphy in six patients, patient . RESULTS: The mean age was 60 years and median parity was 2. The mean operative time was 62 min (range 35-100) and the mean patients, patient90 was 60 ml (range 30-160). The mean follow-up period was 37 months (6-65). Thirteen patients, patient (81%) reported no faecal incontinence, FI after surgery, and two patients, patient (12.5%) reported improvement. One patients, patient (6.5%) had no improvement in her symptom of faecal incontinence, FI after surgery. None of the patients, patient had recurrence of genital prolapse during follow up. CONCLUSION: Sacrospinous colpopexy combined with perineorraphy can help to cure symptoms of faecal incontinence, FI associated with genital prolapse . The possible mechanisms for such a favourable result are discussed.
| null |
840_biomrc
|
Title: XXXX prevalence and treatment benefits in @entity5 : impact of a therapeutic intervention on health outcomes and costs.
BACKGROUND: Lymphedema, lymphedema claim, lymphedema is a common complication of cancer therapeutics; its prevalence, treatment outcomes, and costs have been poorly defined. The objective of this study was to examine Lymphedema, lymphedema claim, lymphedema prevalence among cancer survivors and to characterize changes in clinical outcomes and costs associated with a defined therapeutic intervention (use of a pneumatic compression devices, PCD [ pneumatic compression devices, PCD ]) in a representative, privately insured population. METHODS AND FINDINGS: Retrospective analysis of de-identified health claims data from a large national insurer for calendar years 2007 through 2013. Patients, patients were required to have 12 months of continuous insurance coverage prior to pneumatic compression devices, PCD receipt (baseline), as well as a 12-month follow-up period. Analyses were performed for individuals with cancer -related Lymphedema, lymphedema claim, lymphedema (n=1,065). Lymphedema, lymphedema claim, lymphedema prevalence was calculated: number of Patients, patients with a Lymphedema, lymphedema claim, lymphedema in a calendar year divided by total number of enrollees. The impact of pneumatic compression devices, PCD use was evaluated by comparing rates of a pre-specified set of health outcomes and costs for the 12 months before and after, respectively, pneumatic compression devices, PCD receipt. Lymphedema, lymphedema claim, lymphedema prevalence among cancer survivors increased from 0.95% in 2007 to 1.24% in 2013. pneumatic compression devices, PCD use was associated with decreases in rates of hospitalizations (45% to 32%, p<0.0001), outpatient hospital visits (95% to 90%, p<0.0001), cellulitis diagnoses (28% to 22%, p=0.003), and physical therapy use (50% to 41%, p<0.0001). The average baseline health care costs were high ( 53,422) but decreased in the year after pneumatic compression devices, PCD acquisition (- 11,833, p<0.0001). CONCLUSIONS: Lymphedema, lymphedema claim, lymphedema is a prevalent medical condition that is often a defining attribute of cancer survivorship. The problem is associated with high health care costs; Treatment (in this instance, use of pneumatic compression devices, PCD ) is associated with significant decreases in adverse clinical outcomes and costs.
| null |
842_biomrc
|
Title: Lipid is absorbed in the stomach by @entity2785 (adenomas and XXXX ): a novel functional endoscopy technique.
BACKGROUND AND STUDY AIMS: The authors have successfully demonstrated that the white opaque substance (WOS) identified in gastric epithelial neoplasm, gastric epithelial neoplasms is an accumulation of minute lipid droplets on the epithelial neoplasms, epithelial neoplasm . It is not known whether the lipid droplets originate from externally ingested lipids (typically foods). The purpose of this study was to investigate whether the oral ingestion of foods containing emulsified fats increases the density of the WOS in epithelial neoplasms, epithelial neoplasm . patients, PATIENTS AND METHODS: We examined 92 gastric epithelial neoplastic lesions in 89 patients, PATIENTS . The patients, PATIENTS were given emulsified fatty foods before the procedure, and magnifying endoscopy with narrow-band imaging (M-NBI) was used to image the lesions. An increase in WOS density after the ingestion of emulsified fatty foods was defined as a positive fat-loading test result. The patients, PATIENTS were divided into the following groups: control group, no emulsified fat administered; group 1, fatty food administered 16 hours prior; group 3, fatty food administered both 16 and 4 hours prior. The proportion of positive fat-loading test results was determined in all groups. RESULTS: The rates of positive fat-loading test results were as follows: control group, 9%; group 1, 26%; group 2, 52%; group 3, 78%. The increase in the rates of positive fat-loading test results in groups 2 and 3 relative to the rate in the control group was statistically significant (chi-squared test). CONCLUSIONS: This study demonstrated for the first time that the ingestion of external lipids causes lipid droplets to aggregate in situ on the gastric epithelial neoplasm, gastric epithelial neoplasms . These results can be used to develop a novel functional endoscopy technique that harnesses the lipid absorption capacity of neoplasms .
| null |
4942_biomrc
|
Title: Total ankle replacement or ankle fusion in XXXX advanced @entity2720 of the ankle.
UNASSIGNED: In advanced patients, patient58 hemophilic arthropathy of the ankle, the last resort is surgical treatment ( AA, ankle arthrodesis [ AA, ankle arthrodesis ] or total ankle replacement [TAR]). There is a controversy in the literature on which of the two procedures is more appropriate. A review of the literature was performed to clarify such a controversy. The first search engine was MedLine (keywords: total ankle replacement, AA, ankle arthrodesis ). Seventy articles were found in MedLine. Of these, only 16 were selected and reviewed because they were strictly focused on the topic of this article. The second search engine was the Cochrane Library, where only nine systematic reviews were found on the role of TAR and AA, ankle arthrodesis in non- hemophilia patients, patient . TAR and AA, ankle arthrodesis provide patients, patient58 relief and patients, patient satisfaction in hemophilia patients, patient in the short term. The available non- hemophilia literature is insufficient to conclude which treatment is superior. My current view is that AA, ankle arthrodesis may be preferable in most hemophilia patients, patient .
| null |
846_biomrc
|
Title: Quantifying "normalized" regional left ventricular contractile function in XXXX .
OBJECTIVE: When significant coronary lesions are identified by angiography, regional left ventricular (LV) contractile function often plays a role in determining candidacy for revascularization. To improve on current subjective and nonquantitative metrics of regional LV function, we tested a z-score "normalization" of regional strain information quantified from clinically acquired high-resolution LV geometric datasets. METHODS: Test subjects (n = 120) underwent cardiac MRI with multiple 3-dimensional strain parameters calculated from tissue tag-plane displacement data. Sixty healthy volunteers contributed strain parameter data at each of 15,300 LV grid points, to form a normal human strain, patients, Patient database. Point-specific database comparisons were made in 60 human strain, patients, Patient who had documented CAD, coronary artery disease ( CAD, coronary artery disease ), by angiography. human strain, patients, Patient -specific, color-coded 3-dimensional LV maps of z-score-normalized contractile function were generated. RESULTS: Blinded clinical review indicated that 55% (33 of 60) of the human strain, patients, Patient with CAD, coronary artery disease had significant regional contractile abnormalities by 1 of 3 "gold-standard" criteria: (1) Q waves on electrocardiography (ECG); (2) human strain, patients, Patient188 on radionuclide single-photon emission computed tomography (SPECT); or (3) dyskinesia, akinesia or dyskinesia, akinesia on echocardiography. Consistency among all gold-standard metrics was found for only 19% (6 of 31) of human strain, patients, Patient with CAD, coronary artery disease who had >= 2 available metrics. Blinded MRI-based, multiparametric, strain z-score localization of contractile abnormalities was accurate in 89% (ECG), 97% (SPECT), and 95% (echocardiography). CONCLUSIONS: Nonsubjective normalization of regional LV contractile function by z-score calculation from a normal human strain, patients, Patient database can localize and quantitatively display regional wall motion abnormalities in human strain, patients, Patient with CAD, coronary artery disease . This high-resolution localization of regional wall motion abnormalities may help improve the accuracy of therapeutic intervention in human strain, patients, Patient who have CAD, coronary artery disease .
| null |
848_biomrc
|
Title: Extraordinary exposed in early motherhood - a qualitative study exploring experiences of mothers with @entity164 1 XXXX .
BACKGROUND: women, Women, child with women, Women, child64 1 diabetes face several challenges during pregnancy, childbirth and in relation to breastfeeding. It is therefore of utmost importance to consider their need for specific support, early postpartum as well as in daily life after discharge from maternity care. Few studies have investigated these aspects of healthcare. The aim of this study was to explore experiences after childbirth regarding breastfeeding, glycemic control, support and well-being in women, Women, child with women, Women, child64 1 diabetes . METHODS: A hermeneutic reflective life world research approach was used in this qualitative study. Data was gathered through audio-recorded focus group discussions and individual interviews with 23 women, Women, child with women, Women, child64 1 diabetes , 6-24 months after childbirth. After verbatim transcription, the text was analyzed in order to identify themes of meaning and a conclusive interpretation of the explored phenomenon. RESULTS: Experiences of extraordinary exposure challenged the women, Women, child with women, Women, child64 1 diabetes in their transition to early motherhood. The exposure included a struggle with breastfeeding, although with a driving force to succeed. Everyday life was filled with uncertainty and unpredictability related to one's own unstable glycemic control and the women, Women, child down-prioritized their own needs in favor of the women, Women, child . A feeling of being disconnected from professional care further contributed to the experiences of extraordinary exposure. CONCLUSION: In early motherhood women, Women, child with women, Women, child64 1 diabetes have a great need for support in managing daily life postpartum, which requires contemporary approaches to overlap insufficient linkage between health care professionals in maternity and women, Women, child health care, and diabetes care.
| null |
2897_biomrc
|
Title: The Outcomes of @entity1 With Pediatric Acute Respiratory Distress Syndrome: Proceedings From the Pediatric XXXX Consensus Conference.
OBJECTIVE: To provide additional details and evidence behind the recommendations for outcomes assessment of children, patients, Children with taxonomy to define pediatric acute respiratory distress syndrome, acute respiratory distress syndrome, pediatric acute respiratory distress syndrome from the Pediatric acute lung injury, Acute Lung Injury Consensus Conference. DESIGN: Consensus conference of experts in pediatric acute lung injury, Acute Lung Injury . METHODS: A panel of 27 experts met over the course of 2 years to develop a taxonomy to define pediatric acute respiratory distress syndrome, acute respiratory distress syndrome, pediatric acute respiratory distress syndrome and to make recommendations regarding treatment and research priorities. The outcomes subgroup comprised four experts. When published data were lacking, a modified Delphi approach emphasizing strong professional agreement was used. RESULTS: The Pediatric acute lung injury, Acute Lung Injury Consensus Conference experts developed and voted on a total of 151 recommendations addressing the topics related to taxonomy to define pediatric acute respiratory distress syndrome, acute respiratory distress syndrome, pediatric acute respiratory distress syndrome , seven of which related to outcomes after taxonomy to define pediatric acute respiratory distress syndrome, acute respiratory distress syndrome, pediatric acute respiratory distress syndrome . All seven recommendations had strong agreement. children, patients, Children with taxonomy to define pediatric acute respiratory distress syndrome, acute respiratory distress syndrome, pediatric acute respiratory distress syndrome continue to have a high mortality, specifically, in relation to certain comorbidities and etiologies related to taxonomy to define pediatric acute respiratory distress syndrome, acute respiratory distress syndrome, pediatric acute respiratory distress syndrome . Comorbid conditions, such as an immunocompromised state, increase the risk of mortality even further. Likewise, certain etiologies, such as non-pulmonary sepsis , also place children, patients, Children at a higher risk of mortality. Significant long-term effects were reported in adult survivors of taxonomy to define pediatric acute respiratory distress syndrome, acute respiratory distress syndrome, pediatric acute respiratory distress syndrome : diminished lung function and exercise tolerance, reduced quality of life, and diminished neurocognitive function. Little knowledge of long-term outcomes exists in children, patients, Children who survive taxonomy to define pediatric acute respiratory distress syndrome, acute respiratory distress syndrome, pediatric acute respiratory distress syndrome . Characterization of the longer term consequences of taxonomy to define pediatric acute respiratory distress syndrome, acute respiratory distress syndrome, pediatric acute respiratory distress syndrome in children, patients, Children is vital to help identify opportunities for improved therapeutic and rehabilitative strategies that will lessen the long-term burden of taxonomy to define pediatric acute respiratory distress syndrome, acute respiratory distress syndrome, pediatric acute respiratory distress syndrome and improve the quality of life in children, patients, Children . CONCLUSIONS: The Consensus Conference developed pediatric-specific recommendations for taxonomy to define pediatric acute respiratory distress syndrome, acute respiratory distress syndrome, pediatric acute respiratory distress syndrome regarding outcome measures and future research priorities. These recommendations are intended to promote optimization and consistency of care for children, patients, Children with taxonomy to define pediatric acute respiratory distress syndrome, acute respiratory distress syndrome, pediatric acute respiratory distress syndrome and identify areas of uncertainty requiring further investigation.
| null |
4945_biomrc
|
Title: XXXX reporting pattern in a Danish population-based sample of @entity1 and adolescents.
STUDY DESIGN: A cross-sectional survey of 806 pupils in Odense, Denmark was performed. This survey included children and adolescents ages 8 to 10 and 14 to 16 years obtained through two-stage cluster sampling from schools stratified according to school type, location, and socioeconomic character of the uptake area. OBJECTIVES: To establish the 1-month prevalence of neck, middle back, and children643 and the consequences this disorder may have in relation to age and gender. SUMMARY OF BACKGROUND DATA: The differences in definitions of back pain, middle back pain and the variety of age groups included in previous studies make it difficult to draw clear conclusions about the onset of children58 for various spinal regions in the young. METHODS: Information on back children58 within the preceding month, obtained through a standardized interview of 481 children and 325 adolescents, was categorized according to area of children58 , age, and gender. The consequences of back children58 also were studied. RESULTS: The 1-month prevalence of back children58 was 39%. children58 is most common in childhood, whereas children58 and children58 are equally common in adolescence. Neck children58 and children58 in more than one area of the spine are rare in both age groups. No gender differences were found. Of those who had back children58 , 38% also reported some type of consequence, usually either visits to a medical physician or diminished physical activities. CONCLUSIONS: For clinical and research purposes, neck pain , differences in definitions of back pain, middle back pain , and children643 in childhood should be regarded as three specific entities. In future research the data for different age groups should be reported separately.
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2896_biomrc
|
Title: Cranioplasty and Ventriculoperitoneal Shunt Placement after Decompressive Craniectomy: Staged Surgery Is Associated with Fewer XXXX .
OBJECTIVE: Decompressive craniectomy (DC) requires later cranioplasty (CP) in survivors. However, if additional ventriculoperitoneal shunt (VPS) placement due to shunt-dependent Patients, patients, Patient276 is necessary, the optimal timing of both procedures still remains controversial. We therefore analyzed our computerized database concerning the optimal timing of CP and VPS regarding postoperative complications . METHODS: From 2009-2014, 41 cranioplasty procedures with simultaneous or staged VPS placement were performed at the authors' institution. Patients, patients, Patient were stratified into two groups according to the time from CP to VPS ("simultaneous" and "staged"). Patients, patients, Patient characteristics, timing of CP and VPS, as well as procedure-related complications, were assessed and analyzed. RESULTS: Overall CP and VPS were performed simultaneously in 41% and in staged fashion in 59% of the Patients, patients, Patient . The overall complication rate was 27%. Patients, patients, Patient who underwent simultaneous CP and VPS suffered significantly more often from complications compared with Patients, patients, Patient who underwent staged CP and VPS procedures (47% vs. 12%; P = 0.03). Patients, patients, Patient with simultaneous CP and VPS had a significantly higher rate of infectious postoperative complications compared with Patients, patients, Patient with staged procedures (P = 0.003). On multivariate analysis, simultaneous CP and VPS procedure was the only significant predictor of postoperative complication after CP and VPS (P = 0.03). CONCLUSION: We provide detailed data on surgical timing and complications for cranioplasty and ventriculoperitoneal shunt placement after DC. The present data suggest that Patients, patients, Patient who undergo staged CP and VPS procedures might benefit from a lower complication rate. This might influence future surgical decision making regarding optimal timing of CP and VPS placement.
| null |
856_biomrc
|
Title: Role of @entity1920 -activated protein kinase in glycogen synthase activity and @entity413 utilization: insights from XXXX with @entity9847 .
It has been suggested that humans, patients920 -activated protein kinase ( AMPK ) is involved in the regulation of glucose and glycogen metabolism in skeletal muscle. We used humans, patients with chronic high muscle glycogen stores and deficient glycogenolysis ( McArdle, "McArdles disease" ) as a model to address this issue. Six McArdle, "McArdles disease" humans, patients were compared with control subjects during exercise. Muscle alpha2AMPK activity increased in McArdle, "McArdles disease" humans, patients (from 1.3 +/- 0.2 to 1.9 +/- 0.2 pmol min(-1) mg(-1), P = 0.05) but not in control subjects (from 1.0 +/- 0.1 to 1.3 +/- 0.3 pmol min(-1) mg(-1)). Exercise-induced phosphorylation of the in vivo AMPK substrate acetyl CoA carboxylase (ACCbeta; Ser(221)) was higher (P < 0.01) in McArdle, "McArdles disease" humans, patients than in control subjects (18 +/- 3 vs. 10 +/- 1 arbitrary units). Exercise-induced whole-body glucose utilization was also higher in McArdle, "McArdles disease" humans, patients than in control subjects (P < 0.05). No correlation between individual AMPK or ACCbeta values and glucose utilization was observed. GS, Glycogen synthase ( GS, Glycogen synthase ) activity was decreased in McArdle, "McArdles disease" humans, patients from 11 +/- 1.3 to 5 +/- 1.2 % (P < 0.05) and increased in control subjects from 19 +/- 1.6 to 23 +/- 2.3 % (P < 0.05) in response to exercise. This was not associated with activity changes of GS, Glycogen synthase kinase 3 or protein phosphatase 1, but the changes in GS, Glycogen synthase activity could be due to changes in activity of AMPK or protein kinase A (PKA) as a negative correlation between either ACCbeta phosphorylation (Ser(221)) or plasma humans, patients425 and GS, Glycogen synthase activity was observed. These findings suggest that GS, Glycogen synthase activity is increased by glycogen breakdown and decreased by AMPK and possibly PKA activation and that the resultant GS, Glycogen synthase activity depends on the relative strengths of the various stimuli. Furthermore, AMPK may be involved in the regulation of glucose utilization during exercise in humans, patients , although the lack of correlation between individual AMPK activity or ACCbeta phosphorylation (Ser(221)) values and individual glucose utilization during exercise implies that AMPK may not be an essential regulator.
| null |
4954_biomrc
|
Title: Epidemiology of cervical and XXXX of the proximal femur in 1994 in Tangshan, China.
The purpose of this study was to determine the incidence of cervical and women, patients, men73 of the proximal femur in 1994 in Tangshan City, China. There are many reports on hip women, patients, men74 incidence in many countries, suggesting that there are many factors affecting women, patients, men73 . We visited 15 hospitals with an orthopaedic department within Tangshan City, and reviewed the medical records and radiographs of all women, patients, men with women, patients, men73 occurring between January 1 and December 31, 1994. The population of Tangshan in 1994 was determined to be 1,454,543 (746,015 males and 708,528 females). The population of those over 65 years of age was 88,490 (41,519 males and 46,971 females), representing 6.08% of the total population. This study detected 184 cervical and women, patients, men73 of the proximal femur in 1994 in Tangshan (127 women, patients, men and 57 women, patients, men ). The overall incidence or rate of the combined number of cervical and women, patients, men73 was 25 women, patients, men74 per 100,000 population per year for women, patients, men and 12 for women, patients, men . There were a total of 147 cervical women, patients, men74 (80%) and 37 women, patients, men73 (20%). The incidence of the combined number of cervical and women, patients, men73 in women, patients, men over 70 years of age increased to 108 for women, patients, men and 156 for women, patients, men . The incidence of women, patients, men73 increased with age in both sex groups, especially in women, patients, men over 65. Severe trauma women, patients, men74 happened more often in younger groups, and mainly occurred in women, patients, men , which may be a result of the particular composition of the population in Tangshan, which is young and male dominated. In addition, because Tangshan is an industrial city, many of its citizens are involved in occupations requiring a high level of physical activity.
| null |
4955_biomrc
|
Title: @entity810 during liver transplantation as determined by XXXX .
renal dysfunction, renal injury10 ( renal dysfunction, renal injury10 ) has significant prognostic implications for long-term outcomes in patients, patient undergoing liver transplantation. In several retrospective studies, perioperative variables have been associated with renal dysfunction, renal injury10 . These variables have been mainly associated with changes in patients, patient011 concentrations over several days or months post-transplantation. To better define renal dysfunction, renal injury10 , new markers have become available that help to identify patients, patient at risk for renal dysfunction, renal injury within hours of a triggering insult. We prospectively enrolled liver transplant patients, patient at our institutions to evaluate patients, patient5901 ( patients, patient5901 ), a marker of early renal dysfunction, renal injury , as a surrogate for renal dysfunction, renal injury10 in patients, patient undergoing liver transplantation. Blood was prospectively collected at predetermined time points from 59 patients, patient at 2 institutions. The electronic anesthesia records and the hospital computer data system were reviewed for perioperative variables. Data collection included patients, patient demographics, intraoperative variables such as fluid management, transfusion requirements, hemodynamics, and urine output. Subsequently, patients, patient were grouped according to the presence of risk for developing renal dysfunction, renal injury10 as defined by the RIFLE (risk, patients, patient77 , loss, and end-stage kidney disease ) criteria. The difference between the patients, patient5901 concentration 2 hours after reperfusion and the baseline patients, patient5901 concentration was predictive of renal dysfunction, renal injury10 in all patients, patient , including patients, patient with preexisting renal dysfunction, renal injury . In patients, patient with patients, patient011 concentrations less than 1.5 mg/dL, a single patients, patient5901 determination 2 hours after reperfusion of the liver was associated with the development of renal dysfunction, renal injury10 . Total occlusion of the inferior vena cava was associated with renal dysfunction, renal injury10 . In conclusion, patients, patient5901 concentrations obtained during surgery were highly associated with postoperative renal dysfunction, renal injury10 in patients, patient undergoing liver transplantation. These findings will allow the design of larger interventional studies. Our findings regarding the impact of surgical techniques and glucose require validation in larger studies.
| null |
4956_biomrc
|
Title: Involvement of @entity467 in mitochondrial apoptosis by XXXX under ambient UV radiation.
Paraphenylenediamine ( human0155 ), a derivative of paranitroaniline has been most commonly used as an ingredient of oxidative hair dye and permanent tattoos. We have studied the phototoxic potential of human0155 under ambient ultraviolet radiation. human0155 is photodegraded and form a novel photoproduct under UV A exposure. human0155 shows a concentration dependent decrease in cell viability of human Keratinocyte cells (HaCaT) through MTT and NRU test. Significant intracellular ROS generation was measured by DCFDA assay. It caused an oxidative DNA damage via single stranded DNA breaks, micronuclei and CPD formation. Both lysosome and mitochondria is main target for human0155 induced apoptosis which was proved through lysosomal destabilization and release of Cathepsin B, cathepsin B by immunofluorescence, real time PCR and western blot analysis. Cathepsin B, cathepsin B process BID to active tBID which induces the release of cytochrome C from mitochondria. Mitochondrial depolarization was reported through transmission electron microscopy. The cathepsin inhibitor reduced the release of cytochrome C in human0155 treated cells. Thus study suggests that human0155 leads to apoptosis via the involvement of lysosome and mitochondria both under ambient UV radiation. Therefore, photosensitizing nature of hair dye ingredients should be tested before coming to market as a cosmetic product for the safety of human beings.
| null |
865_biomrc
|
Title: @entity4176 -induced epileptogenesis alters circular hole board learning strategy but not the performance of C57BL/6J XXXX .
Patients with mesial Patients315 (mTLE) frequently show cognitive impairment, cognitive deficits . However, the relation between mTLE and cognitive impairment, cognitive deficits is poorly understood. To gain more insight into epilepsy -associated alterations in cognitive performance, we studied the spatial learning of C57BL/6J Patients9 five weeks after kainate -induced Patients59 ( Patients59 ). Typically, structural hippocampal rearrangements take place within five weeks after Patients59 . Patients9 were monitored by exposing them to four tasks with a focus on spatial memory and Patients48 : the circular hole board, modified hole board, novel object-placement task, and elevated plus maze. On the circular hole board, animals showed a higher preference for hippocampus-independent strategies after Patients59 . In contrast, no change in strategy was seen on the modified hole board, but animals with Patients59 were able to finish the task more often. Animals did not have an increased preference for a relocated object in the novel object-placement task but showed an increased locomotion after Patients59 . No indications for altered Patients48 were found when tested on the elevated plus maze following Patients59 . These data suggest that the circular hole board is a well-suited paradigm to detect subtle Patients59 -induced Patients31 .
| null |
2914_biomrc
|
Title: Selection Indices and Multivariate Analysis Show Similar Results in the Evaluation of Growth and Carcass Traits in Beef XXXX .
UNASSIGNED: This research evaluated a multivariate approach as an alternative tool for the purpose of selection regarding expected progeny differences (EPDs). Data were fitted using a multi-trait model and consisted of growth traits (birth weight and weights at 120, 210, 365 and 450 days of age) and carcass traits ( longissimus muscle area (LMA), back-fat thickness (BF), and RF, rump fat thickness ( RF, rump fat thickness )), registered over 21 years in extensive breeding systems of Polled Nellore cattle in Brazil. Multivariate analyses were performed using standardized (zero mean and unit variance) EPDs. The k mean method revealed that the best fit of data occurred using three clusters (k = 3) (P < 0.001). Estimates of genetic correlation among growth and carcass traits and the estimates of heritability were moderate to high, suggesting that a correlated response approach is suitable for practical decision making. Estimates of correlation between selection indices and the multivariate index (LD1) were moderate to high, ranging from 0.48 to 0.97. This reveals that both types of indices give similar results and that the multivariate approach is reliable for the purpose of selection. The alternative tool seems very handy when economic weights are not available or in cases where more rapid identification of the best animals is desired. Interestingly, multivariate analysis allowed forecasting information based on the relationships among breeding values (EPDs). Also, it enabled fine discrimination, rapid data summarization after genetic evaluation, and permitted accounting for maternal ability and the genetic direct potential of the animals. In addition, we recommend the use of longissimus muscle area and subcutaneous fat thickness as selection criteria, to allow estimation of breeding values before the first mating season in order to accelerate the response to individual selection.
| null |
4966_biomrc
|
Title: Diagnosing and treating XXXX .
It is important to distinguish between diverticula, diverticulosis , the presence of asymptomatic diverticula, diverticulosis , and Diverticular disease, diverticular disease which refers to symptomatic cases which can present with acute or chronic symptoms. Chronic symptoms range from mild intermittent abdominal cramps to the more severe picture of chronic abdominal pain and occasional rectal bleeding . In contrast, acute diverticulitis refers to acute inflammation in the diverticula, diverticulosis . Low dietary fibre intake is reported to increase the risk of Diverticular disease, diverticular disease . In the UK, the prevalence rises from approximately 5% of Patients, patients, patient, people in their 40s to almost 50% of those above the age of 80. It is estimated that 20% of Patients, patients, patient, people with diverticula, diverticulosis will develop symptoms at some point in their lifetime. Diverticular disease, diverticular disease can be confirmed radiologically or endoscopically. Referral of Patients, patients, patient, people with symptomatic Diverticular disease, diverticular disease to secondary care is not indicated unless: the symptoms affect their quality of life; the Patients, patients, patient, people58 is not controlled by Patients, patients, patient, people443 ; new symptoms develop which require further investigation; there are concerns about the possibility of an alternative diagnosis or Patients, patients, patient, people develop red flag symptoms. Even in Patients, patients, patient, people with established diverticula, diverticulosis , a change in the clinical picture with development of red flag symptoms warrants urgent referral to rule out lower gastrointestinal malignancy . Patients, patients, patient, people with suspected uncomplicated acute diverticulitis should be assessed according to their level of Patients, patients, patient, people58 and associated systemic features of sepsis, systemic sepsis . In those where Patients, patients, patient, people58 is controlled and there are no signs of sepsis, systemic sepsis or multiple comorbidities, the Patients, patients, patient, people may be treated in primary care.
| null |
871_biomrc
|
Title: XXXX release by a stimulus train lowers @entity955 threshold.
This study was designed to evaluate the importance of local release of autonomic neuromediators when electrical stimuli are applied to the right atrium to measure the atrial fibrillation, fibrillation threshold (AFT). Experiments were performed in 16 open-chest dogs anesthetized with alpha-chloralose . The dogs were denervated by bilateral transection of the stellates and cervical vagi. The AFT was determined in 11 dogs by delivering either a train of stimuli (14 pulses, 4 ms, 100 Hz) or a single stimulus (10 ms) to the right atrium during its vulnerable period. In eight dogs , beta-adrenergic blockade with timolol (0.1 mg/kg) had no effect on the AFT determined with either method. Atropine, atropine (0.2 mg/kg), given after timolol , significantly increased the train-of-pulses AFT from 4.7 +/- 0.4 to 32.3 +/- 4.6 mA (P less than 0.001). The single-pulse AFT increased from 16.5 +/- 1.5 to 17.8 +/- 1.5 mA (P less than 0.05). Atropine, atropine had a similar effect on the AFT when it was given in the absence of timolol (n = 3). In five additional dogs , a monophasic action potential was recorded while a 10-mA train was delivered to the atrium during its absolute refractory period. There was marked shortening of the monophasic action potential duration (55 +/- 6 ms) in the first beat after the train. The shortening was totally abolished by Atropine, atropine (0.2 mg/kg). The results suggest that a train of stimuli liberates local stores of acetylcholine , which cause a shortening of atrial repolarization time and a profound decrease in the current necessary to evoke atrial fibrillation, fibrillation .
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4969_biomrc
|
Title: XXXX achieved by retrograde intracavitary saline perfusion.
BACKGROUND AND PURPOSE: hypothermia, Hypothermia during vascular clamping protects the kidney from ischemia -induced nephron loss . Traditionally, cooling is achieved by packing the kidney in ice, which lowers the temperature of the rest of the surgical field as well, and the method cannot be used during laparoscopy. We evaluated the utility of a newly developed ureteral access system for circulating ice-cold saline. MATERIALS AND METHODS: Domestic pigs underwent retrograde endoscopic cooling through an access sheath without (N = 2) or with (N = 3) renal artery occlusion , traditional ice-slush cooling with renal artery occlusion (N = 3), or occlusion without hypothermia, Hypothermia (N = 3). Five days later, the pigs were sacrificed and the kidneys and ureters examined histologically. RESULTS: Endoscopic cooling with renal artery occlusion and ice-slush cooling both produced renal hypothermia . The former produced medullary and cortical temperatures of 21.3 degrees C and 27.3 degrees C, respectively, and the latter medullary and cortical temperatures of 28.8 degrees C and 23.7 degrees C, respectively. Histologically, there were minimal changes in the first three groups, whereas venous congestion , multifocal chronic inflammation , and periarteriolar hemorrhage were seen after renal artery occlusion without hypothermia, Hypothermia . CONCLUSION: Retrograde endoscopic renal hypothermia is effective and requires no novel equipment or special surgical skills. Clinical application has not yet been attempted.
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2923_biomrc
|
Title: Efficacy of coupled low-volume plasma exchange with plasma filtration adsorption in treating XXXX with @entity879 : A randomised study.
BACKGROUND _ AIMS: Extracorporeal blood purification systems for supportive therapy of liver failure are widely used. We developed a novel blood purification system, named Li 's artificial liver system ( Li - ALS ), which couples low-volume plasma exchange ( low-volume PE ) with plasma filtration adsorption (PFA). This study aims to evaluate the efficacy of our novel system in pigs, Pigs with ALF, acute liver failure ( ALF, acute liver failure ). METHODS: Thirty-two pigs, Pigs were infused with D-galactosamine (1.3g/kg) to induce ALF, acute liver failure . All animals were equally and randomly divided into four groups: the ALF, acute liver failure control group received intensive care, the PFA group underwent five hour plasma recycling filtration and adsorption purification, the low-volume PE group received one hour low-volume PE , and the Li - ALS group underwent one hour low-volume PE , followed by five hour PFA. Intervention was initiated 36hours after drug administration. The efficacy of each treatment was assessed by survival time and improvement in hematological, biochemical, and immunohistological parameters. RESULTS: pigs, Pigs in the Li- ALS group survived longer than those in the other groups (p<0.001, ALF, acute liver failure control: 60 2h; PFA group: 74 2h; low-volume PE group: 75 2h; and Li - ALS group: 90 3h). Liver enzyme, bilirubin , bile acid and blood ammonia levels were decreased significantly after Li - ALS treatment, and increases in inflammatory cytokines were ameliorated. A higher hepatocyte regeneration index was also observed in the Li- ALS group. CONCLUSION: Our novel Li - ALS could expedite liver regeneration and improve survival time; hence, it could be promising for treating ALF, acute liver failure .
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876_biomrc
|
Title: Potentiation of the analgesic properties of @entity3575 -like opioids with alpha 2-adrenoceptor agonists in XXXX .
BACKGROUND: Data on the analgesic properties of alpha 2 agonists and their interactions with opioids are conflicting. Experiments were conducted in rats to evaluate whether various available alpha 2 agonists can potentiate the analgesic properties of opioids and to determine the route of administration needed for optimal interaction. METHODS: The tail-withdrawal reaction test was used as an analgesia assay. In separate experiments, the interactions between systemic (subcutaneous, intravenous, and intraperitoneal) and spinally (epidural and intrathecal) administered alpha 2 agonists and opioids were evaluated. The antagonism of medetomidine plus rats75 with naloxone and/or idazoxan also was studied. RESULTS: All alpha 2 agonists tested, when injected subcutaneously with rats75 , potentiated the opioid-induced analgesia . In terms of a reduction of the amount of rats75 needed to produce a deep surgical analgesia (tail-withdrawal reaction latency > or = 10 s) over more than 2 h, the relative order of potency of the alpha 2 agonists tested was: medetomidine > dexmedetomidine > xylazine > clonidine > detomidine . For some of these alpha 2 agonists there was a biphasic effect: at the larger doses tested, a reduction in the rats75 potentiation was present. The potentiation of the opioid activity with alpha 2 agonists was also demonstrated in terms of a longer duration of analgesia after combined treatment with fixed doses of opioids. The interaction between the alpha 2 agonists and the opioids remained present when a more profound criterion of analgesia (tail-withdrawal reaction latency > or = 30 s) was used. Furthermore, the interactions between the alpha 2 agonists tested and rats75 or sufentanil appeared to be independent of the route of administration. Potentiations were observed after simultaneous subcutaneous injections of both groups of compounds, after the combination of intraperitoneal (alpha 2 agonist) plus subcutaneous (opioid), intravenous (alpha 2 agonist) plus epidural (opioid) and simultaneous epidural or intrathecal administrations. With regard to antagonism of the analgesic activity of combined treatment with alpha 2 agonists plus opioids, naloxone provided total antagonism, whereas the alpha 2 antagonist idazoxan overcame only the alpha 2 agonist-induced potentiation of rats75 . CONCLUSIONS: The tested alpha 2 agonists can potentiate the analgesic properties of opioids, but they have no intrinsic antinociceptive effects on spinal reflexes on their own. The potentiating activities of the alpha 2 agonists could be measured both in terms of a reduction of the amount of opioid needed to reach a particular level of analgesia and in terms of a longer duration of analgesia with a fixed dose of the opioid. The potentiations were observed with various alpha 2 agonists and opioids and appeared independent of the routes of administration.
| null |
4977_biomrc
|
Title: Synergistic Binding of XXXX and its Receptors to Heparin Selectively Modulates Complex Affinity.
UNASSIGNED: Angiogenesis is a highly regulated process orchestrated by the VEGF system. Heparin/heparan sulfate (HS) proteoglycans and NRP-1, neuropilin-1 ( NRP-1, neuropilin-1 ) have been identified as co-receptors, yet the mechanisms of action have not been fully defined. In the present study we characterized molecular interactions between receptors and co-receptors, using surface plasmon resonance (SPR) and in vitro binding assays. Additionally, we demonstrate these binding events are relevant to VEGF activity witihin endothelial cells. We defined interactions and structural requirements for heparin/HS interactions with VEGF receptor-1, VEGFR-1 ( VEGF receptor-1, VEGFR-1 ), NRP-1, neuropilin-1 , and VEGF165 in complex with VEGFR-2 and NRP-1, neuropilin-1 . We demonstrate that these structural requirements are distinct for each interaction. We further show that VEGF165 , VEGFR-2 and monomeric NRP-1, neuropilin-1 bind weakly to heparin alone, yet show synergistic binding to heparin when presented together in various combinations. This synergistic binding appears to translate to alterations in VEGF signaling in endothelial cells. We found that soluble NRP-1, neuropilin-1 increases VEGF binding and activation of VEGFR-2 and Erk1/2 in endothelial cells, and that these effects require sulfated HS. These data suggest that the presence of HS/heparin and NRP-1, neuropilin-1 may dictate the specific receptor type activated by VEGF and ultimately determine the biological output of the system. The ability of co-receptors to fine-tune VEGF responsiveness suggests the possibility that VEGF -mediated angiogenesis can be selectively stimulated or inhibited by targeting HS/heparin and NRP-1, neuropilin-1 .
| null |
2931_biomrc
|
Title: [Olfactory neuroblastoma ( XXXX ): etiopatogenesis, diagnosis, and treatment].
INTRODUCTION: Esthesioneuroblastoma, esthesioneuroblastoma is a Tumour, malignant tumour, tumour arising from the olfactory epithelium located in the upper part of the nasal cavities. Recent clinical and preclinical studies shed more light on etiopathogenesis, diagnosis, and treatment of this rare malignancy. MATERIAL AND METHODS: A systematic review of PubMed/Medline and available Polish literature. RESULTS: Molecular studies indicate basal progenitor cells of the olfactory epithelium as the origin of Esthesioneuroblastoma, esthesioneuroblastoma . Tumour, malignant tumour, tumour symptoms are related to its location and typically include: epistaxis , nasal obstruction, olfactory and ophtalmic disturbances as well as craniofacial pain . Esthesioneuroblastoma, esthesioneuroblastoma should be differentiated from embryonic rhabdomyosarcoma , "Ewings sarcoma" , melanoma , lymphoma , and pericytoma. A combination of surgery and radiotherapy seems to be the optimum approach to treatment. More aggressive treatment regimens are promising but require further studies. CONCLUSIONS: Esthesioneuroblastoma, esthesioneuroblastoma is a rare Tumour, malignant tumour, tumour arising from the olfactory epithelium. Early diagnosis and interdisciplinary approach to treatment is vital in the management of the Tumour, malignant tumour, tumour .
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885_biomrc
|
Title: [Radiosurgery for XXXX : medium- and long-term results].
OBJECTIVE: To describe the personal experiences of treating patients, patient5265 ( patients, patient5265 ) with gamma knife or cyberknife and evaluate the medium and long-term outcomes. METHODS: From June 1999 to December 2008, 20 patients, patient5265 patients, patient were treated by radiosurgery (gamma knife or cyberknife). Among them, 11 had residual tumor after surgery and 9 were diagnosed by neuroradiology. All cases on magnetic resonance imaging (MRI) showed well-defined and homogeneous hyperintensity on T2-weighted images. The mean maximum diameter of tumor, giant tumors, tumors was 38.7 9.3 mm (range: 23.0 - 60.6). The volume of tumor, giant tumors, tumors ranged between 4.1 - 52.6 cm(3) with a mean of (18.7 12.5) cm(3). The tumor, giant tumors, tumors margin dose irradiated by gamma knife ranged from 9 to 16 Gy (mean 12.3 2.3 Gy). The tumor, giant tumors, tumors margin dose irradiated by cyberknife was 20 - 21 Gy in 3 fractions. The mean follow-up period was (60 32) months (range: 12 - 120). RESULTS: Follow-up imaging showed tumor, giant tumors, tumors volume decreased over 90% (n = 5), tumor, giant tumors, tumors regressed over 50% in volume (n = 9) and no change in tumor, giant tumors, tumors volume (n = 1). One patients, patient with large tumor, giant tumors, tumors (irradiated 10 Gy) was operated by open surgery at 5 months after gamma knife. Four tumor, giant tumors, tumors decreased over 50% in volume after cyberknife. Neurologically, none of these patients, patient showed any deterioration. And 16 patients, patient demonstrated an obvious improvement after radiosurgery. At the last follow-up, there were no complications related to radiosurgery. CONCLUSION: Radiosurgery (Gamma knife or cyberknife) is a safe and effective modality for small- and medium-sized patients, patient5265 . Fractionated Cyberknife proves to be an effective treatment for large or giant patients, patient5265 . Thus radiosurgery will be an alternative option to surgery.
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2934_biomrc
|
Title: The efficacy and tolerability of XXXX once a week for the treatment of @entity170 .
This study evaluated the efficacy and tolerability of risedronate, Risedronate once a week (35 mg and 50 mg) compared with risedronate, Risedronate 5 mg once daily in women with women70 . We conducted a randomized, double-blind, active-controlled, 2-year study; the primary efficacy assessment was performed after 1 year. Subjects were women aged 50 years or older who had been postmenopausal for at least 5 years, with either a bone mineral density, BMD ( bone mineral density, BMD ) T-score of -2.5 or lower (lumbar spine or proximal femur) or a T-score lower than -2 and at least one prevalent women74 . Subjects received risedronate, Risedronate 5 mg once daily, 35 mg once a week or 50 mg once a week. All subjects also received 1 g daily of elemental calcium supplementation and supplemental vitamin D if the baseline serum levels were low. The primary efficacy measure was percent change in lumbar spine bone mineral density, BMD at 12 months. A total of 1,456 women were randomized and received medication; 1,209 (83%) women completed 12 months. The mean percent change (SE) in lumbar spine bone mineral density, BMD after 12 months was 4.0% (0.2%) in the 5 mg daily group, 3.9% (0.2%) in the 35 mg group, and 4.2% (0.2%) in the 50 mg group; each once-a-week treatment was determined to be as effective as the daily treatment. Outcomes of the secondary efficacy measurements and safety assessments were also similar in all 3 groups after 12 months. risedronate, Risedronate 35 mg and 50 mg once a week provide the same efficacy and safety as the daily 5 mg regimen; therefore, the lower dose, 35 mg once a week, is considered optimal for women with women70 who desire a once-a-week regimen.
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2935_biomrc
|
Title: Electrical activity in chromaffin cells of intact XXXX adrenal gland.
Membrane potentials of medullary chromaffin cells of the adrenal gland of the mouse were measured in situ. Resting potential (-54.3 +/- 8.8 mV) depended on extracellular [K+] as predicted by the constant-field equation with a permeability ratio, PNa/PK, of 0.09. Current-voltage (I-V) relationships showed that the current is rectified across the chromaffin cell membrane. A rectification ratio of 0.4 was calculated from the slopes of the I-V curves for positive (41 +/- 26 M omega ) and negative (103 +/- M omega ) currents. Because input resistance for a resting chromaffin cell in isolation is approximately 5 G omega, the chromaffin cells in situ behave as if they were electrically coupled. Most cells responded to depolarizing current pulses with repetitive action potentials, but only 50% of them showed spontaneous electrical activity. Spontaneous activity was often seen in the presence of tetrodotoxin (3 microM). Although the application of the K+-channel blockers tetraethylammonium and Ba2+ greatly increased the amplitude of the action potentials, only Ba2+ induced continuous electrical activity. Application of acetylcholine ( ACh ) always depolarized the cell membrane. This effect was blocked by atropine but not by D-tubocurarine , suggesting that ACh stimulation of chromaffin cells in the mouse involves activation of muscarinic receptors.
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2936_biomrc
|
Title: New growth charts: soy, XXXX , and breast milk comparison.
Weight and length measurements were recorded for 1583 babies during the 1st year of life. The population sample was fairly constant and composed of infant, children from white, middle and upper income families seen in the private practice of 11 pediatricians in Dallas, Texas. This study was part of a larger research effort to determine how diets during the 1st 6 months affect subsequent development of allergy . The babies were subdivided into 3 groups according to family history for allergy and 3 groups according to diet ( cow , breast or soy milk) during the 1st 6 months. After examination at birth, the babies were reexamined monthly up to 6 months of age and bimonthly thereafter up to age 1. Nearly 22,000 observations were made in all. Tables and charts were constructed showing mean weight and length measurements plotted from birth through 38 weeks against 24 possible combinations of sex, family allergy history, and diet. No significant difference was detectable between subgroups when differences in birth weight were taken into account. Compared with the Iowa norms for infant, children growth which were established from measurements taken 1926-49, these babies grew taller in the 1st year of life; weight differences were minimal. Revised infant, children growth charts, more consistent with today's growth patterns, are needed.
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4987_biomrc
|
Title: Role of the autonomic nervous system in the control of heart rate and blood pressure in the defence reaction in conscious XXXX .
The present study was performed on conscious, chronically instrumented dog, dogs , which underwent selective blockade of sympathetic adrenergic and vagal outflows. Excitements were performed on these animals in normal states (N), after chronic treatment with guanethidine , for sympathetic blockade (SB), after cold vagal blockade (VB), and after combined sympathetic and vagal blockade (SB + VB). Heart rate and arterial blood pressure were monitored in all the experiments, while a group of dog, dogs was also tested with an electromagnetic flowmeter on the superior mesenteric artery. The role of the sympathetic and parasympathetic controls in the defence reaction was assumed from comparison of experiments performed in the presence or in the absence of each (or both) autonomic component(s). In the SB + VB condition, excitement was followed by sudden fall of arterial blood pressure, sudden hypotension, hypotension , without changes in heart rate. In VB experiments, a brief and transient sudden fall of arterial blood pressure, sudden hypotension, hypotension appeared, followed by gradually developed hypertension , while heart rate progressively rose in about 5 s; there was no sudden increase in mesenteric vascular resistance, which contrasted with the very marked reaction in N experiments. Under vagal control alone (SB), the stimulus elicited prompt tachycardia and hypertension , followed by a period of moderately reduced blood pressure. We conclude that, while the defence reaction leads to a sudden fall of arterial blood pressure, sudden hypotension, hypotension , in the absence of compensatory mechanisms, both branches of the autonomic nervous system play a protective role against sudden fall of arterial blood pressure, sudden hypotension, hypotension . In addition, the modulation of the vagal outflow, leading to sudden changes in the heart performance, seems to be responsible for the initiation of the overall haemodynamic adjustments following excitements. The possibility that withdrawal of the parasympathetic outflow to the heart may raise arterial blood pressure was verified in a special experiment in which artificial vagal stimulation in a conscious (vagal blocked) dog, dogs , was turned off for brief periods, before and after guanethidine . This led to changes in blood pressure and heart rate very similar to those seen at the onset of the defence reaction, both in N and SB conditions.
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4988_biomrc
|
Title: Adolescent Diet and Time Use Clusters and Associations With XXXX and Socioeconomic Position.
UNASSIGNED: Risk factors for adolescent overweight and obesity include low levels of physical activity, high levels of sedentary behavior, low fruit and vegetable intake, and low socioeconomic position (SEP). To date, the vast majority of research investigating associations between lifestyle behaviors and weight status analyze dietary and time use factors separately. Our research aimed to describe Australian youth time use and diet clusters and explore relationships with weight status and SEP (parental education and income). Cluster analysis of the National Children, girls, boys 's Nutrition and Physical Activity Survey data from Australians aged 9 to 16 years (random sample n = 1,853) was conducted. Time use data (17 age-adjusted time use variables) and dietary data (7 age-adjusted diet variables) were collected via 24-hour recalls. Two clusters were associated with a reduced frequency of overweight and obesity (the Children, girls, boys ' Active Sitter and Children, girls, boys ' Healthy Academic clusters ) and one with an increased frequency of overweight and obesity (the Children, girls, boys ' Unhealthy cluster). Of these three clusters, two demonstrated associations with parental income and/or parental education level. The Children, girls, boys ' Unhealthy cluster was associated with low SEP status (parental income and education), and the Children, girls, boys ' Healthy Academic cluster was associated with high parental income. Not all unhealthy adolescent clusters were associated with overweight and obesity . The findings suggest sex-specific diet and activity clusters can be used to identify at-risk subgroups and inform multifaceted interventions to address overweight and obesity .
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2941_biomrc
|
Title: [Abdominal complications in XXXX ].
We conducted a 4-year retrospective study (1996-1999) in order to assess the abdominal events in patients on peritoneal dialysis, PD, bacterial peritonitis, peritonitis ( peritoneal dialysis, PD, bacterial peritonitis, peritonitis ), as well as the technique failure and the death incidence. We enrolled 127 patients in two french dialysis centers, who presented 9 enteric peritoneal dialysis, PD, bacterial peritonitis, peritonitis (13.2% of the total peritoneal dialysis, PD, bacterial peritonitis, peritonitis episodes), occurring 7.6 +/- 7.9 months after peritoneal dialysis, PD, bacterial peritonitis, peritonitis treatment. Surgery (8 patients ) and definitive technique failure (7 patients ) were necessary. hernia, Hernias were the most frequent with 32.6% of the total abdominal complications. They were either umbilical (7 patients ), or inguinal (5 patients ) or hiatal (3 patients ). Six patients continued on peritoneal dialysis, PD, bacterial peritonitis, peritonitis without disruption whereas 6 patients had a transient stop and thereafter returned to peritoneal dialysis, PD, bacterial peritonitis, peritonitis . The other abdominal complications such as gastric and duodenal ulcus (5 patients ), oesophagogastric reflux (5 patients ), liver diseases (9 patients ) occurred during peritoneal dialysis, PD, bacterial peritonitis, peritonitis treatment without any relationship with the treatment modality. In the diabetic population, abdominal complications were not more frequent but they took place more quickly than in the non diabetic population (5.5 +/- 3.8 months versus 12.9 +/- 16.3 months with p < 0.01). A rapid diagnosis, especially in case of enteric peritoneal dialysis, PD, bacterial peritonitis, peritonitis , is mandatory to avoid "abdominal catastrophes" mainly due to patients30 . The incidence of hernia, Hernias could be decreased if a good clinical approach is effective before peritoneal dialysis, PD, bacterial peritonitis, peritonitis treatment.
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4990_biomrc
|
Title: @entity4346 in incident dialysis XXXX randomized to treatment with hemofiltration or hemodialysis: results from the ProFil study.
INTRODUCTION: Left ventricular hypertrophy, LVH ( Left ventricular hypertrophy, LVH ) is present in a majority of hemodialysis (HD) patients and is among the strongest risk factors for cardiovascular events and mortality. Hemofiltration (HF), a purely convective dialysis treatment, has been associated with enhanced hemodynamic stability compared with HD, possibly as a result of a more physiologic removal of fluid and solutes. METHODS: In a randomized controlled study conducted at ten dialysis centers in Sweden and Denmark, incident patients (HD <3 months) without clinical signs or history of cardiovascular disease were randomized to treatment with either online, predilution HF or low-flux HD. The primary endpoint was change in patients002 ( patients002 ), as measured by two-dimensional M-mode and Doppler echocardiography. RESULTS: The analyses included 34 patients (18 HF, 16 HD) followed for up to 2 years. At baseline, 65% of the patients had Left ventricular hypertrophy, LVH , but patients002 did not differ between the study groups. In the HF group, patients002 decreased by 22 48 g/m(2) during a mean treatment time of 19 7 months, while in the HD group the decrease was 15 57 g/m(2) during 16 7 months. As analyzed by MANOVA (mixed model), the difference in patients002 over the whole period was statistically significant (p = 0.03) with a more favorable outcome in HF. Blood pressure and other study variables did not differ between the groups, but at baseline and throughout the study, HF patients required heavier antihypertensive treatment. CONCLUSIONS: In incident dialysis patients , long-term predilution HF, a purely convective dialysis treatment, is associated with a significantly more favorable development of patients002 compared with regular low-flux HD. Considering the predictive strength of patients002 as a risk factor, the quantitative difference between the treatments is of clinical importance.
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895_biomrc
|
Title: [Retrospective investigation on the cases treated with liposomal XXXX ].
We have retrospectively investigated clinical profile, efficacy, and safety in 41 patients who were treated with liposomal amphotericin B ( patients9095 ) in Aichi Medical University Hospital between January 2008 and June 2009. It turned out that patients9095 was used for severe patients66 and 31.7% cases discontinued patients9095 therapy because of death . patients9095 was administered as the second-line therapy in 56.1% (23/41), and was not effective in 48.8% (20/41). patients9095 was administered as the first-line therapy in 43.9% (18/41); (1) 1 for cryptotoccal infection , (2) 7 for severe sepsis or septic shock , (3) 2 for the case which cannot remove medical device and might have biofilm formation, (4) 6 for the induction of step-down therapy concept, (5) 2 for febrile patients398 patients who have needed aggressive empiric therapy. There was no significant difference in serum potassium level (p = 0.10) and serum patients011 level (p = 0.05) between pretreatment and posttreatment with patients9095 . The serum patients011 level before initial treatment with patients9095 was 1.31 +/- 1.30 mg/dL. The patients for 7.3% (3 cases) had dialyzed before initial treatment with patients9095 , however, there was no case who need dialysis after administration of patients9095 . As for the highest patients011 level in patients9095 administered cases, 29.3% (12/41) and 24.4% (10/41) were normal to abnormal, and abnormal to abnormal, respectively. This is the first investigational report when the serum patients011 level before initial administration of patients1930 had been abnormal. The other antimicrobial agents, which might have influenced renal function, were administered to 51.2% cases (21/41). That means the cases administered patients9095 might have other bacterial infections . As for the serum patients011 level, we observed the changing cases and the cases which did not cause the change at all regardless of the administering period of patients1930 . The serum potassium level before initial administration of patients9095 was 4.1 +/- 0.8 mEq/L, concomitant use of patients483 etc. was 31.7% (13/41), the lowest serum potassium level was 3.4 +/- 0.9 (1.9-6.2)mEq/L in during using patients9095 , the serum potassium was 34.1% (14/41) in replenish potassium during administration of patients9095 , and the total replenished potassium was 131.25 mEq. We did not observe the case who had died because of the low potassium . Since patients9095 was the only fungicidal drug, when we use patients9095 for the serious patients66 to make the best use of the characteristic, we have to pay attention to the concomitant medication, renal function and the serum potassium level.
| null |
4994_biomrc
|
Title: [Assessment of high blood pressure in 24-hours Holter records in @entity101 pregnant XXXX ].
DESIGN: The aim of our study was to established possible a correlation between Holter blood pressure measurements and BP levels measured incidentally by the medical personnel. We also tried to evaluate usefulness of ABPM in monitoring intensification of the women, patients01 . MATERIALS AND METHODS: The research was performed on 57 pregnant women, patients where pregnancies were complicated by women, patients01 (PIH or chronic women, patients01 ). All women, patients were divided into four groups conforming with JNC VI protocol according to BP level measured in the time of the admission to hospital. Therefore circadian blood pressure profile was done by using ABPM SpaceLab device. After that BP load indicator was estimated in each group to assess intensification of the disease. However, we compared those results between groups by using t-Student test (p < 0.05). RESULTS: We qualified 22 women, patients to group 0 with SBP = 129,45 + 6.31 mmHg and women, patients1559 = 80.59 + 5.45 mmHg in the time of admission. There were 21 pregnant women, patients with mild women, patients01 (group I SBP = 144,14 + 7.32 mmHg, women, patients1559 = 93.14 + 4.52 mmHg), moderate (group II, N = 8 with SBP = 153,88 + 5.54 mmHg and women, patients1559 = 101,34 + 3.78 mmHg) and severe women, patients01 (group III, N = 6 with SBP = 175,83 + 33.23 mmHg, women, patients1559 = 121 + 11.92 mmHg). BP load value measured in group 0 was 14.57 + 21.3% of SBP and 13.92 + 22.99% of women, patients1559 inappropriate results. In group I was found SBP 24.91 + 30.3%, women, patients1559 23.12 + 26.01%, group II SBP 38.11 + 33.66%, women, patients1559 26.31 + 22.75% and in group III SBP 59.3 + 38.76% and women, patients1559 61.37 + 35.72%, respectively. CONCLUSIONS: Only between the group with normal blood pressure and the group with severe women, patients01 the obtained results were statistically significant (p < 0.05). We've also found a statistical correlation between BP values measured in the time of admission to the hospital and BP load indices in each group.
| null |
4999_biomrc
|
Title: Effects of processing delay, temperature, and transport tube type on results of quantitative bacterial culture of XXXX urine.
OBJECTIVE: To determine the impact of processing delay, temperature, and transport tube type on results of quantitative bacterial culture (QBC) of canine, Canine, dogs urine. DESIGN: Diagnostic test evaluation. SAMPLE: 60 mL of pooled urine from 4 canine, Canine, dogs , divided into six 10-mL aliquots. PROCEDURES: Urine aliquots were spiked with bacteria from 1 of 6 independent Escherichia coli cultures to achieve a target bacterial concentration of 10(5) CFUs/mL. One milliliter from each aliquot was transferred into 5 silicone -coated clot tubes (SCTs) and 5 urine transport tubes (UTTs). Samples were stored at 4 C (39 F) and 25 C (77 F) for 0, 8, and 24 hours, and then standard QBCs were performed. RESULTS: Median bacterial concentration for urine samples stored in a UTT for 24 hours at 4 C was lower than that for samples stored in an SCT under the same conditions. Conversely, a substantial decrease in median bacterial concentration was identified for samples stored for 24 hours in an SCT at 25 C, compared with the median concentration for samples stored in a UTT under the same conditions. Median bacterial concentration in samples stored in an SCT at 25 C for 24 hours (275 CFUs/mL) was less than the cutoff typically used to define clinically important bacteriuria by use of urine samples obtained via cystocentesis (ie, > 1,000 CFUs/mL). CONCLUSIONS AND CLINICAL RELEVANCE: canine, Canine, dogs urine samples submitted for immediate QBC should be transported in plain sterile tubes such as SCTs. When prolonged (24-hour) storage at room temperature is anticipated, urine samples should be transported in UTTs.
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2952_biomrc
|
Title: NF-kB/ XXXX and @entity10182 cooperate to maintain hepatocyte integrity and to prevent development of @entity8055 .
BACKGROUND _ AIMS: The liver is frequently challenged by toxins and reactive oxygen species. Therefore, hepatocytes require cytoprotective strategies to cope with these insults. Since the transcription factors women, human, Human0182 and NF-kB regulate the cellular antioxidant defense system and important survival pathways, we determined their individual and overlapping functions in the liver. METHODS: We generated women, human, Human9 lacking women, human, Human0182 and the NF-kB women, human, Human992 / women, human, Human992 subunit in hepatocytes and we analyzed their liver by using histopathology, immunohistochemistry, quantitative RT-PCR, Western blot and Oxyblot analysis. women, human, Human inflammatory hepatocellular adenomas, iHCA ( inflammatory hepatocellular adenomas, iHCA ) were analyzed by immunohistochemistry. RESULTS: Loss of either women, human, Human0182 or NF-kB/ women, human, Human992 had only a minor effect on liver homeostasis, but the double knockout women, human, Human9 spontaneously developed liver inflammation and fibrosis . Upon aging, more than one-third of the female double mutant women, human, Human9 developed tumor, tumors , which histologically resemble women, human, Human inflammatory hepatocellular adenomas, iHCA , a tumor, tumors that predominantly occurs in women, human, Human . The women, human, Human9 tumor, tumors also recapitulated the immunohistochemical marker profile characteristic for women, human, Human inflammatory hepatocellular adenomas, iHCA . Moreover, pNRF2 and NF-kB women, human, Human992 / women, human, Human992 was not detectable in the nuclei of inflammatory hepatocellular adenomas, iHCA tumor, tumors cells. The women, human, Human9 phenotype was not due to a synergistic effect of both transcription factors on cytoprotective women, human, Human0182 target genes. Rather, loss of women, human, Human0182 or NF-kB/ women, human, Human992 altered the expression of different genes, and the combination of these alterations likely affects liver homeostasis in the double mutant women, human, Human9 . CONCLUSIONS: Our results provide genetic evidence for a functional cross-talk of women, human, Human0182 and NF-kB/ women, human, Human992 in hepatocytes, which protects the liver from necrosis , inflammation and fibrosis . Furthermore, the double mutant women, human, Human9 represent a valuable animal model for inflammatory hepatocellular adenomas, iHCA .
| null |
2954_biomrc
|
Title: [ XXXX in selected heamatology departments in the Czech Republic and Slovakia - microbiological results of the CAN CELL project].
BACKGROUND: The aim of our study was to analyze the spectrum and characteristic of invasive candidiasis, Invasive candidiasis in selected haematological departments in the Czech and Slovak Republics, and to compare MIC, minimum inhibitory concentrations ( MIC, minimum inhibitory concentrations ) of some antifungal agents for isolates obtained. MATERIAL AND METHODS: Between 1 March 2009 and 31 October 2010, Candida strains from clinically important material obtained from patients with haematological malignancies were collected. Each isolate was biochemically identified and tested for in vitro susceptibility to three known malignancies626 and amphotericin B and selected azoles using the E-test. Relevant clinical data were collected. RESULTS: The study included 63 isolates from 61 patients . The most frequently isolated species were malignancies132 and C. glabrata (28 % and 19 %, respectively). However, after exclusion of isolates from bronchoalveolar lavage fluid, the percentage changed in favour of malignancies132 and C. parapsilosis (25 % and 17 respectively). The MIC, minimum inhibitory concentrations data showed a high susceptibility of yeasts to malignancies626 and amphotericin B . Ten (16 %) strains were cross-resistant to azoles (mostly C. glabrata ). CONCLUSION: invasive candidiasis, Invasive candidiasis is not frequent infection complication in patients with haematological malignancies in the Czech Republic and Slovakia. Moreover, the spectrum of pathogens was similar to that described in recent international studies. However, identification of susceptible and resistant strains according to MIC, minimum inhibitory concentrations could be beneficial for choice of antifungal treatment.
| null |
908_biomrc
|
Title: Conservative reconstruction using stents as salvage therapy for disruption of esophago-gastric XXXX .
Esophagectomy with extended lymphadenectomy and gastric conduit reconstruction is a radical procedure for the treatment of esophageal cancer that is associated with a high morbidity rate. Gastric conduit necrotic, necrosis, gastric conduit necrosis is a fatal complication that occurs in 2% of patients, patient, man . Conventionally, two-stage salvage surgery consisting of removal of the necrotic, necrosis, gastric conduit necrosis gastric conduit followed by reconstruction has been performed; however, this procedure has a high morbidity rate. We describe a 61-year-old patients, patient, man who underwent minimally invasive esophagectomy complicated by slowly progressive necrotic, necrosis, gastric conduit necrosis associated with patients, patient, man35 and a stable overall condition. There was a 2 cm gap in the anastomosis . Because there was no evidence of residual necrotic, necrosis, gastric conduit necrosis , a removable, covered patients, patient, man702 ( patients, patient, man702 ) was inserted to bridge the anastomosis . The stent was fixed to the patients, patient, man 's ear with silk thread through the lasso on its proximal end to prevent migration. Eight weeks after insertion, the stent was removed easily without any associated complications. The anastomotic defect was completely bridged with granulation tissue, showing progressive epithelialization without leakage or stenosis . The patients, patient, man was discharged home in good general health. This is the first report of the successful conservative management of esophago-gastric conduit anastomosis disruption with patients, patient, man702 placement.
| null |
2956_biomrc
|
Title: Remodeling of gap junctions in @entity19 hearts hypertrophied by forced XXXX signaling.
BACKGROUND: Beta-MHC, beta-MHC - hRARalpha human9 express a constitutively active (truncated) form of the human human968 receptor which triggers development of dilated cardiomyopathy . In those hearts, we studied expression of gap junction proteins in relation to electrical impulse propagation. METHODS AND RESULTS: As compared to wildtype human9 , hearts of 4-6 month old human9 with 7-12 inserted hRARalpha copies are marked by an increased heart weight/body weight- and heart weight/tibia length ratio. 3-extremity lead ECGs revealed prolongation of the Q-j interval suggesting delayed ventricular activation. Mapping of electrical activity of epi- and endocardial left ventricular free wall revealed activation delay, increased heterogeneity in conduction and regional conduction block. human165 did not occur spontaneously nor could be induced by ventricular pacing. Immunohistochemical analysis showed profound and heterogeneous redistribution and down-regulation of the gap junction protein human6899 ( human6899 ) in the left ventricular free wall. Here, hRARalpha expression induced re-expression of the hypertrophic markers alpha-skeletal actin and Beta-MHC, beta-MHC , and in 3 out of 10 severely affected human9 , re-expression of human6898 . Concomitant with changes in expression/distribution of human6899 , changes in expression and distribution of human2401 and N-cadherin (two other intercalated disk associated proteins) were observed. CONCLUSIONS: Beta-MHC, beta-MHC - hRARalpha transgenic hearts show heterogeneous re-expression of (early) sarcomeric genes while expression of human6899 , N-cadherin and human2401 is down-regulated. We postulate that the resulting aberrant ventricular activation does not trigger development of lethal arrhythmias due to the small size of remaining healthy ventricular tissue where the transgene is not expressed.
| null |
913_biomrc
|
Title: XXXX pelvic and limb perfusion with melphalan and @entity1138 for recurrent limb @entity320 : a pilot study.
Hypoxic, hypoxic pelvic and limb perfusion by means of a balloon occlusion technique was evaluated in patients with recurrent melanoma of the lower limbs who were non-responders to isolated hyperthermic limb perfusion or who were not eligible for this procedure. A pilot study was performed in 17 patients , who underwent Hypoxic, hypoxic pelvic and limb perfusion with 50 mg/m(2) of melphalan or 50 mg/m(2) of melphalan and 25 mg/m(2) of patients138 . Each procedure was followed by haemofiltration. A leakage monitoring study was performed in five of the 17 patients . The response rate and time to disease progression were the primary endpoints, with overall survival as the secondary endpoint. During the procedures there were no technical, haemodynamic or vascular complications , and no deaths occurred during surgery or in the postoperative period. Significant leakage (median 40%) was measured in the five patients studied. No severe patients37 was observed. After one course of treatment, the objective response rate was 47% (95% confidence interval 22.5-71.5%), the median time to disease progression was 10 months (range 2-40 months), and the 3 year overall survival was 20%. Hypoxic, hypoxic pelvic and limb perfusion seems to be a safe and effective treatment for patients with unresectable recurrent limb melanoma who are not eligible for isolated hyperthermic limb perfusion. Due to the non-homogeneity of the study, with some patients receiving a combination of melphalan and patients138 and others receiving only melphalan, it is not possible to make definite conclusions with regard to efficacy. Further studies are necessary to establish whether the response rates can be improved by using different drug regimens.
| null |
2961_biomrc
|
Title: Influence of experimental XXXX on blood and myocardial @entity750 in @entity35 .
Recent reports suggest a role for serotonin, Serotonin in the pathogenesis of primary hypertension and left ventricular (LV) hypertrophy . In this study, we have induced LV hypertrophy by oral feeding of thyroxine, Thyroxine at increasing dosages (150-450 micrograms/kg b.wt.) over a 5-week period. The effects of hyperthyroidism, hyperthyroid on cardiovascular parameters , blood and myocardial serotonin, Serotonin concentrations were assessed. Water-fed rats and formerly hyperthyroidism, hyperthyroid recovered animals served as controls. thyroxine, Thyroxine caused a significant LV hypertrophy : hyperthyroidism, hyperthyroid rats 2.19 +/- 0.16*; controls 1.65 +/- 0.13 g/kg b.wt. (mean +/- SD; *P less than 0.05). An almost complete regression of LV hypertrophy occurred in the recovery group (1.66 +/- 0.20 g/kg b.wt.) 3 weeks after cessation of thyroid hormone application. thyroxine, Thyroxine -treated animals showed a significant increase of serotonin, Serotonin blood levels ( thyroxine, Thyroxine rats : 2108 +/- 781*, recovery: 1132 +/- 726, controls: 705 +/- 480 ng/ml; *P less than 0.05). The concentrations of serotonin, Serotonin in left ventricular myocardium were increased after thyroid hormone application, whereas the highest levels were found in the recovery group ( thyroxine, Thyroxine rats : 139.1 +/- 30.4, recovery: 167.2 +/- 43.1, controls: 68.9 +/- 27.9 mg/ml homogenate). serotonin, Serotonin -containing cells in the left ventricular myocardium were stained immunohistochemically. They were localized perivascularly and were assumed to represent tissue mast cells. In experimental hyperthyroidism, hyperthyroid the serotonin, Serotonin levels in blood and heart are increased possibly indicating an interaction of both hormones in thyroxine, Thyroxine -induced cardiomyopathy .
| null |
916_biomrc
|
Title: Covered expandable metallic stent placement for hemostasis of colonic bleeding caused by invasion of XXXX .
A 72-year-old Japanese patient, man was admitted to our hospital complaining of right upper-quadrant abdominal pain , blood in his stool, and symptoms of anemia . On physical examination a hard mass, about 6 cm in diameter, was palpable in the right upper quadrant of the abdomen. Computed tomography revealed a patient, man086 which had invaded the transverse colon, with liver metastasis . We diagnosed patient, man086 , stage IVB. Colonoscopy was performed for persistent blood in the stools. This revealed an elevated lesion which appeared to be an invasion of patient, man086 , with bleeding, diffuse bleeding from the right-side of the transverse colon. It proved difficult to stop this bleeding, diffuse bleeding by ordinary therapeutic endoscopy. In order to achieve hemostasis we therefore inserted a covered Ultraflex metallic stent to compress the tumor . After stent placement, blood was no longer seen in the patient, man 's stools, he became able to eat soft food and was discharged. This treatment was uninvasive and effective. Covered stent placement appears to be a new and useful method in the management of bleeding, diffuse bleeding from malignant patient, man820 .
| null |
2976_biomrc
|
Title: Occupational factors and the incidence of XXXX in Canada.
During 1979-82, a case-control study of occupational factors and women, men50 was conducted in Edmonton, Calgary, Toronto, and Kingston, Canada. A total of 826 histologically verified cases of cancer were individually matched by sex, age, and area of residence to 792 randomly selected population controls. Subjects were specifically asked about employment in several industries thought relevant to risk of women, men50 . Information was also obtained on lifelong occupational history, with special attention given regarding exposures to fumes, dusts, smoke, and chemicals. In addition, subjects provided data on past medical and residential history, on intake of certain dietary items, and on exposure to tobacco and other lifestyle factors. Conditional logistic regression methods were used for the analysis. Under adjustment for cumulative lifetime cigarette consumption, it appeared that for both women, men and women, men , most of the occupational factors examined were not associated with significant alteration in risk of women, men50 . For exposures during the period eight to 28 years before diagnosis, however, raised risk was suggested for women, men employed at least six months in the chemicals industry (odds ratio = 2.37, p = 0.004), in dye manufacturing or the dyeing of cloth (OR = 3.62 and 4.63, p = 0.041 and 0.035, respectively), as tailors (OR = 3.85, p = 0.015), or in jobs in which contact with diesel or traffic fumes occurred (OR = 1.69, p = 0.0008). Increased risk was also seen for women, men occupationally exposed to tars or asphalt (OR = 3.11, p = 0.019). This study then, at least for women, men , supports perhaps a few of the suspect industries as related to risk of women, men50 .
| null |
2984_biomrc
|
Title: Eating meals before wheel-running exercise attenuate high fat diet-driven @entity28 in XXXX under two meals per day schedule.
UNASSIGNED: Mice that exercise after meals gain less body weight and visceral fat compared to those that exercised before meals under a one meal/exercise time per day schedule. Humans generally eat two or three meals per day, and rarely have only one meal. To extend our previous observations, we examined here whether a "two meals, two exercise sessions per day" schedule was optimal in terms of maintaining a healthy body weight. In this experiment, "morning" refers to the beginning of the active phase (the "morning" for nocturnal animals). We found that 2-h feeding before 2-h exercise in the morning and evening (F-Ex/F-Ex) resulted in greater attenuation of high fat diet (HFD)-induced Humans017 compared to other combinations of feeding and exercise under two daily meals and two daily exercise periods. There were no significant differences in total food intake and total wheel counts, but feeding before exercise in the morning groups (F-Ex/F-Ex and F-Ex/Ex-F) increased the morning wheel counts. These results suggest that habitual exercise after feeding in the morning and evening is more effective for preventing HFD-induced Humans017 . We also determined whether there were any correlations between food intake, wheel rotation, visceral fat volume and skeletal muscle volumes. We found positive associations between gastrocnemius muscle volumes and morning wheel counts, as well as negative associations between morning food intake volumes/body weight and morning wheel counts. These results suggest that morning exercise-induced increase of muscle volume may refer to anti- obesity . Evening exercise is negatively associated with fat volume increases, suggesting that this practice may counteract fat deposition. Our multifactorial analysis revealed that morning food intake helps to increase exercise, and that evening exercise reduced fat volumes. Thus, exercise in the morning or evening is important for preventing the onset of obesity .
| null |
938_biomrc
|
Title: Cigarette smoke augments @entity5089 production via the @entity6800 - XXXX pathway in airway epithelial cells.
BACKGROUND: human800 are a major cause of human030 ( human030 ) exacerbations. Toll-like receptor 3, TLR3 ( Toll-like receptor 3, TLR3 ) reacts with double-stranded RNA (dsRNA) and participates in the immune response after human800 . In the present study, we examined whether cigarette smoke, which is involved in the pathogenesis of human030 , enhances mucin production via the TLR3-epidermal growth factor receptor, EGFR ( TLR3-epidermal growth factor receptor, EGFR ) pathway in airway epithelial cells. METHODS: We studied the effects of human981 ( human981 ) on signal transduction and the production of MUC5AC, mucin 5AC ( MUC5AC, mucin 5AC ) in NCI-H292 cells and differentiated primary human bronchial epithelial cells stimulated with a synthetic dsRNA analogue, human4018 [ human4018 ], used as a Toll-like receptor 3, TLR3 ligand. RESULTS: human981 significantly potentiated the production of MUC5AC, mucin 5AC in epithelial cells stimulated with poly(I:C). Antibodies to TLR3-epidermal growth factor receptor, EGFR or TLR3-epidermal growth factor receptor, EGFR ligands inhibited human981 -augmented MUC5AC, mucin 5AC release in poly(I:C)-treated cells. Treatment with poly(I:C) or human981 alone increased the phosphorylation of TLR3-epidermal growth factor receptor, EGFR and extracellular signal-regulated kinase, ERK ( extracellular signal-regulated kinase, ERK ). However, after poly(I:C) stimulation, human981 did not enhance TLR3-epidermal growth factor receptor, EGFR phosphorylation, but did augment extracellular signal-regulated kinase, ERK phosphorylation. TLR3-epidermal growth factor receptor, EGFR inhibitors and an extracellular signal-regulated kinase, ERK inhibitor inhibited the augmented release of MUC5AC, mucin 5AC . In addition, treatment with N-acetylcysteine , an antioxidant, inhibited the human981 -augmented phosphorylation of extracellular signal-regulated kinase, ERK and MUC5AC, mucin 5AC . CONCLUSIONS: These data show that cigarette smoke increases Toll-like receptor 3, TLR3 -stimulated MUC5AC, mucin 5AC production in airway epithelial cells, mainly via extracellular signal-regulated kinase, ERK signaling. The effect might be mediated in part by oxidative stress. Modulation of this pathway might be a therapeutic target for viral-induced mucin overproduction in human030 exacerbation.
| null |
2987_biomrc
|
Title: Cellular Changes during Renal Failure-Induced Inflammatory XXXX .
BACKGROUND: Aortic valve calcification, AVC ( Aortic valve calcification, AVC ) secondary to renal failure, RF ( renal failure, RF ) is an inflammation-regulated process, but its pathogenesis remains unknown. We sought to assess the cellular processes that are involved in the early phases of aortic valve disease using a unique animal model of renal failure, RF -associated Aortic valve calcification, AVC . METHODS: Aortic valves were obtained from rats that were fed a uremia -inducing diet exclusively for 2, 3, 4, 5, and 6 weeks as well as from controls. Pathological examination of the valves included histological characterization, von Kossa staining, and antigen expression analyses. RESULTS: After 2 weeks, we noted a significant increase in urea and creatinine levels, reflecting renal failure, RF . renal failure, RF parameters exacerbated until the Week 5 and plateaued. Whereas no histological changes or calcification was observed in the valves of any study group, macrophage accumulation became apparent as early as 2 weeks after the diet was started and rose after 3 weeks. By western blot, osteoblast markers were expressed after 2 weeks on the diet and decreased after 6 weeks. Collagen 3 was up-regulated after 3 weeks, plateauing at 4 weeks, whereas collagen 1 levels peaked at 2 and 4 weeks. Fibronectin levels increased gradually until Week 5 and decreased at 6 weeks. We observed early activation of the ERK pathway, whereas other pathways remained unchanged. CONCLUSIONS: We concluded that renal failure, RF induces dramatic changes at the cellular level, including macrophage accumulation, activation of cell signaling pathway and extracellular matrix modification. These changes precede valve calcification and may increase propensity for calcification , and have to be investigated further.
| null |
940_biomrc
|
Title: @entity55 antigens facilitate experimental @entity384 : prevention with XXXX .
OBJECTIVE: The purpose of this study was to investigate whether Chlamydia pneumoniae (live, antigens, or polysaccharide) cause abdominal aortic aneurysm in a susceptible animal host with appropriate drug reversal. METHODS: At laparotomy, preparations of C pneumoniae (live, formalin -inactivated, and heat-inactivated) in calcium chloride were applied to the adventitial surface of the abdominal aorta of rabbits fed a cholesterol -enriched diet. Aortic diameter was measured with ultrasonography. After 3 weeks, immunohistochemistry was used to detect aortic C pneumoniae and macrophages. Presence of C pneumoniae DNA also was assessed. RESULTS: At high doses (5 x 10(7) organisms) periaortic application of both live and formalin -inactivated preparations resulted in doubling of aortic diameter after 3 weeks, from 2.0 +/- 0.5 mm to 4.3 +/- 1.3 mm (P <.02). C pneumoniae DNA and antigens, together with a heavy macrophage infiltrate, were detected in the dilated aorta. In contrast, periaortic application of heat-inactivated preparations resulted in minimal macrophage influx and aneurysmal dilatation, aortic dilatation . Treatment of rabbits with azithromycin, Azithromycin or carprofen for 10 days after laparotomy abolished the effects of formalin -inactivated C pneumoniae on aneurysmal dilatation, aortic dilatation . azithromycin, Azithromycin reduced the number of macrophages in the aortic wall more effectively than carprofen . CONCLUSION: Because membrane antigenicity is retained in formalin -inactivated but not heat-inactivated organisms, in this experimental model, chlamydial membrane antigens (rather than live organisms) appear to cause the aneurysmal dilatation, aortic dilatation and associated macrophage recruitment. azithromycin, Azithromycin is likely to reverse these effects with an antiinflammatory mechanism.
| null |
941_biomrc
|
Title: Feasibility and effectiveness of activity-scheduling as a guided self-help intervention for the prevention of @entity308 and XXXX in residents in homes for the elderly: a pragmatic randomized controlled trial.
BACKGROUND: Elderly participants, Participants, people living in residential homes are at high risk for developing major depressive and anxiety disorders, depression , and therefore deserve attention in terms of preventive interventions. We evaluated the feasibility and effectiveness of a guided self-help intervention for the prevention of depressive and anxiety disorders, depression and participants, Participants, people48 in these residents. METHODS: We conducted a pragmatic randomized controlled trial in two parallel groups comparing the intervention with usual care in 14 residential homes in and surrounding the city of Amsterdam in the Netherlands. A total of 129 residents with a score of 8 or more on the Centre for Epidemiologic Studies Depression Scale (CES-D) screening instrument, who did not meet the full diagnostic criteria for disorders, and were not suffering from cognitive impairment were recruited between April 2007 and December 2008. participants, Participants, people were randomized to a guided self-help intervention (n = 67) or to usual care (n = 62). The main outcome measures were improvement in the level of symptoms of depressive and anxiety disorders, depression and participants, Participants, people48 . The secondary outcome was improvement in participation in organized activities in the residential homes. The study is registered in de Dutch Cochrane Centre, under number ISRCTN27540731. RESULTS: Only 21% of the participants, Participants, people (mean age 84.0 years (SD 6.7), 72.1% suffering from two or more participants, Participants, people02 ) completed the intervention. Although we found some large positive effect sizes on the CES-D, none of these effects was statistically significant. CONCLUSION: Although guided self-help may be promising in the prevention of depressive and anxiety disorders, depression and participants, Participants, people48 , it proved to be difficult to apply in this very old and vulnerable group of participants, Participants, people living in residential homes.
| null |
944_biomrc
|
Title: The Inhibitory Effect of XXXX on Melanoma Cancer @entity3 and Invasiveness In vitro and In vivo.
UNASSIGNED: metastasis20 cell metastasis is the primary cause of patient death . Thus, various treatment strategies have been developed to prevent metastasis . patient5174 (AA) is an organic compound commonly found in trees. This study is aimed to investigate the antimetastatic activity of AA in B16F10-xenografted C57BL/6 patient9 and assess the anticancer activity of AA in combination with patient311 in metastasis20 cells. AA effectively reduced the formation of lung metastases by approximately 92.8%. AA treatment inhibited migratory potential ([Formula: see text]), invasion ([Formula: see text]), and motility ([Formula: see text]) of highly metastatic patient9 metastasis20 cells in vitro. Zymography revealed that AA reduced the proteinase activities of matrix metalloproteinase-2 and urokinase-type plasminogen activator. Molecular analyses showed that AA reduced Akt phosphorylation and activating protein-1 DNA-binding activity by Western blot and electrophoretic mobility shift assay (EMSA), respectively. In summary, AA effectively inhibited B16F10 lung metastasis , and 50[Formula: see text][Formula: see text]M AA did not affect the viability of patient9 cells. AA improved the efficacy of patient311 and demonstrated strong anticancer activity on metastasis20 cells. These results suggested that AA could be used as an antimetastatic agent or as an adjuvant for anticancer therapy.
| null |
945_biomrc
|
Title: Living well with XXXX : enhancing dignity and quality of life, using a novel intervention, Dignity Therapy.
AIMS AND OBJECTIVES: To assess the feasibility, acceptability and potential effectiveness of Dignity Therapy to improve the quality of life and reduce psychological and spiritual distress in older patients, Patient, person, people with early stage Dementia, dementia . BACKGROUND: Dementia, dementia is a syndrome with several causes that leads to a progressive decline in multiple areas of functioning. The maintenance of dignity and enhancement of quality of life are key elements of care. Meaningful communication may become more difficult with condition progression. Improvements in communication may have positive effects on the patients, Patient, person, people 's quality of life. Dignity Therapy is a short psychotherapeutic intervention that uses a trained therapist to take the patients, Patient, person, people with Dementia, dementia through a guided interview process, producing a 'generativity' document that creates a lasting, written legacy during a time when they are still able to communicate well. DESIGN AND METHOD: This was a feasibility mixed method study. Dignity Therapy was undertaken with patients, Patient, person, people diagnosed as having early stage Dementia, dementia . Data were gathe-red from pre- and post-Dignity Therapy interviews, a focus group, interviews with key stakeholders, and three outcome measures: The Herth Hope Index; The patients, Patient, person, people Dignity Inventory; Perceived Quality of Life/Satisfaction with Quality Life Ratings. FINDINGS: This study demonstrated that Dignity Therapy is feasible, acceptable and potentially effective for older patients, Patient, person, people with Dementia, dementia . Three overarching themes emerged: A life in context, A key to connect and Personal legacy. CONCLUSIONS: We recommend that this feasibility study forms the basis for further study, advocating the prospective benefits to patients, Patient, person, people with Dementia, dementia , families and nursing practice. IMPLICATIONS FOR PRACTICE: Dignity Therapy, as a psychosocial intervention, has the potential to improve the quality of life and enhance patients, Patient, person, people centred care for patients, Patient, person, people with Dementia, dementia .
| null |
2995_biomrc
|
Title: Upper-extremity volume measurements in @entity1 with XXXX : a comparison of measurements obtained via water displacement with geometrically determined volume.
BACKGROUND AND PURPOSE: edematous, Upper-extremity (UE) swelling following breast cancer treatment is a frequent manifestation of edematous, Upper-extremity (UE) swelling269 . In order to document outcomes from edematous, Upper-extremity (UE) swelling269 treatments, reliable, valid, and practical measurements of UE swelling are necessary. The purpose of this study was to compare geometric methods of determining UE volumes with water displacement methods. SUBJECTS: The edematous, Upper-extremity (UE) swelling hand, forearm, and upper arm of 50 women with UE swelling secondary to edematous, Upper-extremity (UE) swelling269 were measured. METHODS: Upper-extremity volumes were determined by water displacement using arm and hand volumeters. Displaced water was weighed to determine volume. Circumferential girth measurements were taken. Width and depth measurements of the hand were taken with a tension-controlled caliper. Geometric volume formulas for a cylinder, frustum, rectangular solid, and trapezoidal solid were used to calculate volumes of the arm and hand at different measurement intervals. RESULTS: Intraclass correlation coefficients [2,1] for interrater and intrarater reliability of all water and geometric measurements of the arm and hand were.91 to.99 and.92 to.99, respectively. Water displacement correlated with geometric measurements in the arm (r=.97-.98) and in the hand (r=.81-.91). The limits of agreement (LOA) indicated that water and geometric measurements of arm volume differed by 479 to 655 mL. Scatterplots of the LOA data indicated in that geometric volumes were either larger or smaller than water volumes. The smallest standard error of measurement for the arm measurements was for the 6-cm frustum method at 115 mL; for the hand measurements, the smallest standard error of measurement was for the frustum method at 16 mL. DISCUSSION AND CONCLUSION: Volume of an edematous, Upper-extremity (UE) swelling UE calculated by geometric formulas correlated strongly with volume determined by water displacement. Although strongly correlated, the measurements obtained by the 2 methods did not agree.
| null |
950_biomrc
|
Title: XXXX : a clinicopathologic and electron microscopic study.
Cardiac rhabdomyomas are rare tumor, tumors of infancy. In a series of 36 patients, patient 78 percent were under 1 year of age, and only one patients, patient was over age 15 years. Ninety percent of the Rhabdomyomas, rhabdomyomas were multiple and occurred with nearly equal frequency in the right and left ventricles. Although reportedly infrequent in the atria, Rhabdomyomas, rhabdomyomas involved either one or both atria in 30 percent of patients, patient . In 50 percent of patients, patient at least one of the tumor, tumors masses was intracavitary and obstructed 50 percent or more of one of the cardiac chambers or valve orifices. Symptoms referable to obstruction of intracardiac blood flow were present in nine patients, patient , none of whom had tuberous sclerosis , and all of whom would appear to have been good surgical candidates. Histologically the Rhabdomyomas, rhabdomyomas were composed of classic "spider cells". Electron microscopic studies revealed scattered bundles of myofibrils ringing these cells and radiating toward the center; glycogen was present both free in the cytoplasm and within mitochondria. Distinct intercellular junctions resembling intercalated discs with well defined desmosomes and nexuses were present. Many of the cells contained leptofibrils, arranged either peripherally or in spiraled clusters in the center of the cell. Rhabdomyomas, rhabdomyomas derive from cardiac muscle cells and appear to represent hamartomas rather than true tumor, tumors .
| null |
958_biomrc
|
Title: The effect of @entity1729 on reported XXXX symptoms.
BACKGROUND: Wheezing and chest tightness is associated with children729 . Thus the occurrence of children729 may influence the prevalence of asthma . AIMS: To assess the strength of relation between two main symptoms of asthma and the prevalence of children729 in children with and without asthma . METHODS: The study population was 3,796 children , four years of age, whose parents had answered a questionnaire on respiratory symptoms and asthma . The prevalence of wheezing and chest tightness in the last 12 months and four weeks was estimated according to the occurrence of children729 during the corresponding time periods; 95% confidence intervals of the prevalence and the statistical significance of the differences in the prevalence by using chi-square test were calculated. RESULTS: The prevalence of wheezing and chest tightness was higher in children who had experienced children729 than in those who had not. The prevalence of wheezing was 17.5% among children who had experienced bronchitis and 3.0% among children whom had not (p<0.001). The prevalence of chest tightness in the last 12 months was 3.7% (95% CI 3.1-4.1) among children without asthma and 59.3% (95% CI 53.4-65.2) among children with asthma (p<0.001). The prevalence of wheezing and chest tightness increased with increasing number of different types of children729 among children without asthma (p<0.001) and tended to be so among children with asthma . CONCLUSIONS: These findings have implications for the interpretation of results from epidemiological studies using respiratory symptoms as a health-related outcome of asthma .
| null |
3009_biomrc
|
Title: Management of epithelial XXXX of low malignant potential.
The distinct pathologic and biologic nature of ovarian tumors, benign ovarian tumors, hereditary ovarian cancer syndromes, ovarian neoplasms of low malignant potential (LMP) has been officially recognized by FIGO and the World Health Organization. LMP tumor, tumors may comprise 10% of ovarian tumors, benign ovarian tumors, hereditary ovarian cancer syndromes, ovarian neoplasms ; they occur at a mean age of 40 years. Pregnancy, breast-feeding, and the use of oral contraceptives are protective against the development of tumor, tumors of LMP. A history of infertility and use of infertility drugs appear to increase the risk of these tumor, tumors . No association with ovarian tumors, benign ovarian tumors, hereditary ovarian cancer syndromes, ovarian neoplasms has been reported. The survival associated with these tumor, tumors is 99% at mean follow-up of 7 years for patients with stage I disease, and 92% for those with stage II and II disease . Retrospectively, more patients appear to have died from complications associated with adjuvant therapy than from progressive disease. The recommended treatment is surgical, consisting of total abdominal hysterectomy, bilateral salpingo-oophorectomy, pelvic and para-aortic lymph node biopsies, peritoneal washings, and tumor, tumors debulking. In young patients with early-stage disease, conservative surgery, preserving the uterus and contralateral ovary, is acceptable. A role has not yet been established for adjuvant therapy, whether radiotherapy or chemotherapy. Laboratory investigations have not demonstrated that these tumor, tumors represent an intermediate step between ovarian tumors, benign ovarian tumors, hereditary ovarian cancer syndromes, ovarian neoplasms and patients89 nor have they identified that small subset of tumor, tumors with patients46 clinical behavior. We should perhaps consider tumor, tumors of LMP in the same light as "benign" proliferative gynecologic conditions, such as endometriosis and leiomyomata .
| null |
961_biomrc
|
Title: Ultrastructural immunocytochemistry of XXXX in the cerebral and cerebellar cortex of the @entity35 .
gamma-aminobutyrate, gamma-Aminobutyrate containing structures in the cerebral and cerebellar cortex of the rat were visualized by an immunocytochemical method using glutaraldehyde fixation and an antiserum developed against a gamma-aminobutyrate, gamma-Aminobutyrate - glutaraldehyde -protein conjugate. Labelled elements (perikarya and cell processes) were observed to be distributed throughout the layers of the cerebral cortex in a pattern similar to that described using glutamate decarboxylase immunocytochemistry. The morphological features of many immunoreactive cell bodies were typical of stellate neurons. In the cerebellar cortex, Purkinje, basket, Golgi and stellate, cell bodies were found to be immunoreactive along with numerous labelled neuronal processes. At the ultrastructural level, the labelled processes in both areas corresponded to immunoreactive dendrites and fibres. Labelled synaptic boutons, generally of the symmetrical type, could also be seen in contact with positive or negative cell bodies and dendrites. In the cerebellum, glomeruli could be clearly identified including mossy fibres surrounded by unlabelled dendrites in contact with immunoreactive terminals. At the subcellular level in both brain regions, the areas occupied by the Golgi apparatus were never labelled, although the nuclei had varied reactions. The strong glutaraldehyde fixation that limits the diffusion of gamma-aminobutyrate, gamma-Aminobutyrate limits also antibody diffusion. However, this fixation is compatible with a good morphological preservation and should enable immunocytochemistry studies to be compared to other methods such as autoradiography.
| null |
3011_biomrc
|
Title: Pharmacokinetics of high-dose @entity70779 in XXXX with @entity1577 .
The pharmacokinetics of high-dose azlocillin sodium was studied in 18 Patients, patients with Patients, patients577 . Nine male and nine female Patients, patients with a mean age of 14.7 years (range 3 to 29 years) participated in the study. They received Patients, patients7286 450 mg/kg/day (as the Patients, patients1929 ) in six divided doses. During a steady-state dosing interval, a dose of Patients, patients7286 was coadministered with a 10-mg/kg dose of Patients, patients0817 as a 30-minute infusion. Serum concentrations of Patients, patients7286 and Patients, patients0817 were determined by high-pressure liquid chromatography assay. The data were analyzed using model-independent methods. The mean elimination rate constant for Patients, patients7286 was 0.64 +/- 0.22 hr-1 and the mean serum half-life was 1.22 +/- 0.39 hr. Total clearance of Patients, patients7286 , calculated by noncompartmental analysis, was 77.2 +/- 26.4 mL/min/sq m. Glomerular filtration rate, as estimated by measuring Patients, patients0817 clearance, was 79.6 +/- 21.9 mL/min/sq m. The total clearance of Patients, patients7286 correlated with Patients, patients0817 clearance. Patients, patients with Patients, patients577 appear to eliminate Patients, patients7286 more rapidly than healthy individuals. This rapid elimination warrants the use of high doses to maintain high serum concentrations.
| null |
3012_biomrc
|
Title: The spectrum of associated @entity75 in XXXX : relation to gestational age and outcome.
OBJECTIVE: To describe different patterns of associated brain lesions in preterm and full-term infants, infant with CSVT, cerebral sinovenous thrombosis ( CSVT, cerebral sinovenous thrombosis ) and to assess whether these different patterns are related to gestational age at onset. DESIGN: Magnetic resonance scans of all neonates (six preterm, 24 full term) with suspected CSVT, cerebral sinovenous thrombosis , collected over a 7-year period in two neonatal intensive care units, were evaluated to assess patterns of associated brain lesions . Comparisons between the two gestational age groups were made. RESULTS: CSVT, cerebral sinovenous thrombosis was confirmed on magnetic resonance venography in 26 of 30 neonates (six preterm, 20>= 36 weeks' gestational age). The straight (85%) and superior sagittal (65%) sinus were most often affected. Several sinuses were involved in 81% of infants, infant . White matter damage affecting the entire periventricular white matter was seen in five of six preterm infants, infant . IVH, Intraventricular haemorrhage, thalamic haemorrhage ( IVH, Intraventricular haemorrhage, thalamic haemorrhage ) was common in both groups (4/6 preterm, 16/20 full term). Frontal punctate white matter lesions, haemorrhage and punctate white matter lesions with restricted diffusion (15/20) and IVH, Intraventricular haemorrhage, thalamic haemorrhage associated with IVH, Intraventricular haemorrhage, thalamic haemorrhage (11/20) were the most frequent lesions in full-term infants, infant . Focal arterial infants, infant188 was present in four of 20 full-term infants, infant . Six infants, infant died in the neonatal period (four preterm, two full term). Follow-up MRIs at 3 months in all survivors showed evolution of the lesions with frontal infants, infant94 in 13 of 20 (12 full term) and delayed myelination in seven of 20 (six full term). CONCLUSIONS: Preterm and full-term neonates show different patterns of associated brain lesions . Extensive white matter damage is the predominant pattern of injury in the preterm infants, infant , while an IVH, Intraventricular haemorrhage, thalamic haemorrhage associated with a thalamic Frontal punctate white matter lesions, haemorrhage and punctate white matter lesions are more common in the full-term infants, infant .
| null |
965_biomrc
|
Title: @entity5572 after non-operative management of blunt XXXX .
BACKGROUND: The non-operative management of blunt liver trauma can be applied in almost 80% of patients, patient with this patients, patient30 , with the advantages of the need for fewer blood transfusions, less patients, patient320 , and a better survival rate, than with the operative approach. However, Liver abscess, liver abscess , as a known complication of the non-operative management of blunt liver trauma , is discussed infrequently. Therefore, we herein review our experience and describe this complication in detail. MATERIALS AND METHODS: From 1995 to 2001, 674 patients, patient were admitted to our hospital due to blunt hepatic injury, liver injury, hepatic trauma . Among these patients, patient , 279 underwent laparotomy and the remaining 395 patients, patient were treated non-operatively. Twenty-two patients, patient were identified as having Liver abscess, liver abscess , with 16 of them belonging to the operative group, and six to the non-operative group. A retrospective review of these six patients, patient and their characteristics, as well as pathogenesis, diagnosis, and the management of the liver abscesses, was conducted. RESULTS: These six patients, patient were all male, with a median age of 19.5 years (range 3-24). The median injury severity score was 16.5 (range 9-25); three patients, patient sustained grade-3 hepatic injury, liver injury, hepatic trauma , and the other three were grade 4. The main diagnostic tool was abdominal computed tomography, and the abscesses took a median of 6 days (range 1-12) to form and be diagnosed. The abscesses were usually caused by infection from mixed organisms, and an abscess resulting from Clostridium infection developed within 1 day after injury. These abscesses were treated with antibiotics and drainage, and the median length of hospital stay was 26 days (range 8-44), without mortality or long-term morbidity. CONCLUSION: Liver abscess, liver abscess as a complication of the non-operative management of blunt hepatic injury, liver injury, hepatic trauma is a rare entity, with an incidence of 1.5% (6/395). It is usually seen in severe hepatic injury, liver injury, hepatic trauma (grade 3 and above), but all our patients, patient were all treated successfully, with no mortality. However, prolonged hospitalization may be required in this patients, patient group.
| null |
970_biomrc
|
Title: A rare presentation of @entity1084 ( @entity1084 ) - The XXXX .
INTRODUCTION: Bouveret's Syndrome is a rare cause of woman, patients084 ( woman, patients084 ) caused by a large gall stone, gall-stone, gall stone which has migrated into the duodenal bulb from a bilioduodenal fistula. It is an uncommon condition and only a few cases have been reported in the medical literature till to date. PRESENTATION OF CASE: We report a case of a 45 year old woman, patients who presented to us with recurrent woman, patients58 in the upper abdomen for the last 8 years, and that progressed to develop symptoms of woman, patients084 . An upper gastrointestinal endoscopy revealed duodenal ulceration with a stony hard lesion in the first part of duodenum. An contrast enhanced computed tomography (CECT) scan of the abdomen performed later confirmed the presence of cholecystoduodenal fistula and a large gall stone, gall-stone, gall stone in proximal jejunum. DISCUSSION: "Bouverets syndrome" is a case of woman, patients084 caused by the impaction of a large gall stone, gall-stone, gall stone in the duodenum as a result of a cholecystoduodenal fistula . It constitutes 1-3% of cases of large gall stone, gall-stone, gall stone ileus which in turn complicates only 0.3-4% cases of cholelithisasis. "Bouverets syndrome" is managed surgically. CONCLUSION: "Bouverets syndrome" being an uncommon condition may pose a difficulty in diagnosis and dilemma in managing such woman, patients . An awareness is hence essential.
| null |
971_biomrc
|
Title: Results with the constrained total knee prosthesis in treating severely disabled XXXX and @entity1 with failed total knee replacements.
Fifty-fix constrained total knee replacements (forty Guepar and sixteen Herbert prostheses) were performed in forty-nine severely disabled arthritic patients and they were followed for two to four years. Seventeen of these knees were operated on to salvage a failed prosthesis. Good relief of patients58 was achieved in 64 per cent of the knees but there was less improvement in walking and function. The over-all range of motion increased because of a reduction in preoperative patients159 . The results in the salvage group were less successful than in those patients who underwent a primary operation. Between six months and one year postoperatively, patients58 had developed in 17 per cent of the fifty-six knees, 9 per cent had walking difficulties, and 7 per cent lost function. patients58 accounted for the unfavorable patients58 ratings in over half of the knees. Zonal roentgenographic analysis of each knee indicated high incidences of radiolucent lines at the cement-bone interface (75 per cent), cement-metal lucencies (68 per cent), and cement deficiencies (73 per cent). Forty-three per cent of the knees showed excessive posterior placement of the prosthesis of more than five millimeters, resulting in patients159 of as much as 5 degrees. Complications requiring reoperation developed in nine knees (16 per cent). There was one case of loosening and three knees had deep infections . Chronic postoperative effusions were present in 48 per cent of the knees. The use of either a cemented metal-on-metal hinged knee replacement or a metal-on- polyethylene hinge type of prosthesis was found to result in a relatively high incidence of patients77 and complications, and did not solve the problem of treating patients with a failed knee prosthesis.
| null |
973_biomrc
|
Title: [Screening childhood behavior problems using short questionnaires II.: The Hungarian version of the SWAN-scale (Strength and Weakness of @entity71 and Normal-behavior) for screening attention XXXX ].
INTRODUCTION: The SWAN (Strength and Weakness of ADHD-symptoms, deficit/hyperactivity disorder and Normal-behavior) Questionnaire is a short instrument suitable for screening attention ADHD-symptoms, deficit/hyperactivity disorder . Its completion by parents or teachers requires a few minutes. Positive re-wording of attention- and activity-related behaviors and the extended 7- point rating scale anchored to average behavior make the instrument especially suitable for normal populations. Here, we report the Hungarian version of SWAN and compare its scales with relevant scales of the participants, Child, children, Infant Behavior Checklist (CBCL) and the Strengths and Difficulties Questionnaire (SDQ). METHOD: Questionnaire data were collected from parents of 156 six-year-old participants, Child, children, Infant in a community sample. Of the 156 participants, Child, children, Infant 89 were participants, Child, children, Infant of the longitudinal Budapest participants, Child, children, Infant -Parent Study (BIPS). RESULTS: Internal consistency of the Hungarian SWAN scales was excellent (Cronbach alfa: 0.87-0.93), correlations with relevant CBCL and SDQ scales were as expected (0.40-0.49 and 0.67-0.74) showing that the short questionnaire was suitable for detection of attention and hyperactivity problems. SWAN scores in our sample were normally distributed and scale means were also similar to foreign studies. CONCLUSIONS: These initial Hungarian data confirm international experience with the SWAN. Psychometric indices, distribution of scale scores in the sample and across the sexes were consistent with foreign studies. Following collection of normative data, the Hungarian version of SWAN might be suitable for assessing mental health of participants, Child, children, Infant and adolescents, and for screening problem cases. Due to the wider range and the normal distribution of scores, SWAN provides a more suitable phenotype for genetic studies, than symptom scales.
| null |
982_biomrc
|
Title: Pure natural orifice translumenal endoscopic surgery management of simple XXXX : 2-year follow-up results.
BACKGROUND AND PURPOSE: Retrograde ureteroscopic marsupialization is a pure natural orifice translumenal endoscopic surgery (NOTES). We retrospectively examined the feasibility and safety of this technique to manage symptomatic simple renal cysts . patients, patient, PATIENTS AND METHODS: Sixteen patients, patient, PATIENTS with simple renal cysts were selected and treated by incising the cyst wall to drain into the collecting system through retrograde ureteroscopy. A retrospective observational study was performed to evaluate the patients, patient, PATIENTS 's symptomatic and radiologic results after ureteroscopic marsupialization. Symptomatic success based on patients, patient, PATIENTS58 relief was evaluated using a visual analog patients, patient, PATIENTS58 scale preoperatively and postoperatively. Radiologic success was defined as no recurrence of the cyst or a reduction in cyst size by at least half. RESULTS: There were no intraoperative or postoperative complications observed. The mean operative time was 35 minutes (range 20-50 min). The mean hospital stay was 3.4 days (range 2-5 d). Of the 16 patients, patient, PATIENTS , one patients, patient, PATIENTS was lost at follow-up. The symptoms based on patients, patient, PATIENTS58 had resolved in 13 (83%) cases but remained in 2 cases at a mean follow-up of 24.2 months (range 6-36 mos). The average visual analog patients, patient, PATIENTS58 scale decreased from 6.7 (range 4-9) to 1.1 (range 0-5) at the sixth month. The mean size of all cysts decreased from 6.8 cm (range 4-10 cm) to 1.3 cm (range 0-5 cm). Radiographic success was achieved in 93% (14/15) of patients, patient, PATIENTS . Cytology and cyst wall pathology reports revealed no evidence of malignancy . CONCLUSIONS: Retrograde ureteroscopic marsupialization is a complete transurethral NOTES marsupialization. With appropriate patients, patient, PATIENTS selection, the minimally invasive retrograde ureteroscopic marsupialization is feasible, safe, and effective. It can be preferred to more invasive laparoscopic or open surgical approaches.
| null |
3031_biomrc
|
Title: The association between epicardial fat thickness and XXXX according to blood pressure status in nonhypertensive individuals: From the CAESAR study.
BACKGROUND: Epicardial adipose tissue represents visceral adiposity, and the coronary artery calcium (CAC) score (CACS) has been suggested as a reasonable surrogate for coronary atherosclerosis . Epicardial fat thickness (EFT) and blood pressure status can be attributed to coronary artery calcification . OBJECTIVE: The present study was performed to evaluate the association between EFT and coronary artery calcification according to blood pressure status in nonhypertensive individuals. METHODS: The CACS and echocardiographic EFT measurement were performed in a total of 1878 nonhypertensive individuals (1535 men ; mean age, 44 8.3 years). Subjects were divided into quartiles according to EFT ( <=2.575, 2.576-3.168, 3.169-3.900, and >3.900 mm) and into 2 groups according to the presence of CAC. Additionally, individuals were classified as normotensive (n = 1064) or men556 (n = 814). RESULTS: The prevalence of CACS >0 group in men556 individuals was 6.1%, 18.1%, 22.6%, and 29.9% in the lowest, second, third, and highest EFT quartiles, respectively (P < .001) and 7.3%, 13.1%, 14.0%, and 13.9% in the normotensive group (P = .050). On multivariate regression analysis, the second, third, and highest quartile EFT groups had higher odds ratios for the presence of CAC than that of the lowest quartile (odds ratio [95% confidence interval], 3.849 [1.215-12.194], 4.069 [1.235-13.412], and 4.383 [1.385-13.875], respectively), although only in men556 individuals. Moreover, an increased absolute EFT level was also associated with increased CACS in men556 individuals (standardized b = 0.101, P = .035). CONCLUSION: This study showed an independent relationship between EFT and coronary artery calcification in nonhypertensive individuals, with variable differences in this association according to blood pressure status.
| null |
989_biomrc
|
Title: Primary cardiac malignant fibrous histiocytoma with vulvar XXXX : A case report.
UNASSIGNED: patient418 ( patient418 ) occurring in the heart is rare. To the best of our knowledge, the current study was the first to report a case of left patient418 metastasizing to the vulva. A 37-year-old female presenting with a history of exertional patient353 underwent echocardiography, which revealed a mass in the left atrium, with a short-wide stalk attached to the posterior wall, extending into the pericardium. Furthermore, the mass resulted in severe mitral stenosis during diastole. The tumor, vulvar tumor was excised together with a section of the left atrial wall. The initial diagnosis was a left atrial myxoma . However, post-operative frozen section histopathology results indicated a diagnosis of patient418 . Following surgery, the patient received chemotherapy, however, vulvar metastases and left patient143 were identified after 1 month. Following surgical excision of the tumor, vulvar tumor and left thoracentesis, the patient began adjuvant chemotherapy. However, the patient succumbed due to local recurrence 6 months later.
| null |
3038_biomrc
|
Title: Hypothermic bypass and XXXX for operations on the descending thoracic and thoracoabdominal aorta.
BACKGROUND: Hypothermic cardiopulmonary bypass with intervals of patients167 is a useful adjunct during operations on the descending thoracic aorta and distal aortic arch when severe aortic disease, thoracic or thoracoabdominal aortic disease precludes placement of clamps on the aorta. Hypothermia also has a marked protective effect on spinal cord function during periods of upper lumbar arteries, aortic occlusion . METHODS: Fifty-one patients (age range, 22 to 79 years) with descending aortic disease, thoracic or thoracoabdominal aortic disease had resection and graft replacement of the diseased aortic segments using hypothermic cardiopulmonary bypass and intervals of patients167 in situations where the location, extent, or severity of disease precluded placement of clamps on the proximal aorta (8 patients ) or (in 43 patients ) when extensive thoracic (11) or thoracoabdominal (32) aortic disease, thoracic or thoracoabdominal aortic disease was present and the risk for development of spinal cord ischemic injury and patients77 was judged to be increased. Patent intercostal (below T-6) and upper lumbar arteries, aortic occlusion were attached to the graft whenever possible. RESULTS: Thirty-day mortality was 9.8% (5 patients ). Paraplegia, paraplegia occurred in 2 and patients746 in 1 of the 46 30-day survivors (6.5%). Among the 27 operative survivors with thoracoabdominal aneurysms, aneurysms, type III aneurysms, degenerative aneurysms , Paraplegia, paraplegia occurred in 1 of 12 with patients96 (8%), 0 of 10 with type II, and 1 of 5 with thoracoabdominal aneurysms, aneurysms, type III aneurysms, degenerative aneurysms (20%). Paraplegia, paraplegia occurred in none of the 12 patients with patients580 and in 2 of the 15 patients with thoracoabdominal aneurysms, aneurysms, type III aneurysms, degenerative aneurysms . patients77 requiring dialysis occurred in 1 (2.2%) of the 46 30-day survivors. CONCLUSIONS: Hypothermic patients167 is a valuable adjunct for the treatment of complex aortic disease, thoracic or thoracoabdominal aortic disease involving the aortic arch and thoracoabdominal aorta. In patients with thoracoabdominal aneurysms, aneurysms, type III aneurysms, degenerative aneurysms , its use has been associated with a low incidence of patients77 and an incidence of Paraplegia, paraplegia / patients746 in traditionally high-risk subsets (type I and II thoracoabdominal aneurysms, aneurysms, type III aneurysms, degenerative aneurysms , patients580 ), which may be less than that observed with other surgical techniques.
| null |
991_biomrc
|
Title: Evolving paradigms in the treatment of opioid-induced XXXX .
In recent years prescription of opioids has increased significantly. Although effective in patients58 management, bothersome gastrointestinal adverse effects are experienced by a substantial proportion of opioid-treated patients . This can lead to difficulties with therapy and subsequently inadequate patients58 relief. Collectively referred to as opioid-induced bowel dysfunction , these adverse effects are the result of binding of exogenous opioids to opioid receptors in the gastrointestinal tract. This leads to disturbance of three important gastrointestinal functions: motility, coordination of sphincter function and secretion. In the clinic this manifests in a wide range of symptoms such as reflux, bloating, abdominal cramping, hard, dry stools, and incomplete evacuation, although the most known adverse effect is opioid-induced patients142 . Traditional treatment with laxatives is often insufficient, but in recent years a number of novel pharmacological approaches have been introduced. In this review the pathophysiology, symptomatology and prevalence of opioid-induced bowel dysfunction is presented along with the benefits and caveats of a suggested consensus definition for opioid-induced patients142 . Finally, traditional treatment is appraised and compared with the latest pharmacological developments. In conclusion, opioid antagonists restricted to the periphery show promising results, but use of different definitions and outcome measures complicate comparison. However, an international working group has recently suggested a consensus definition for opioid-induced patients142 and relevant outcome measures have also been proposed. If investigators within this field adapt the suggested consensus and include symptoms related to dysfunction of the upper gut, it will ease comparison and be a step forward in future research.
| null |
3040_biomrc
|
Title: An adenovirus early region 1A protein is required for maximal viral DNA replication in growth-arrested XXXX cells.
Two closely related adenovirus early region 1A proteins are expressed in transformed cells. The smaller of these, which is 243 human, WI-38522 in length, is required for the transformation of primary rat cells and for the transformation of immortalized rat cells to anchorage-independent growth. This protein is not required for productive infection of exponentially growing HeLa cells but is required for maximal replication in growth (G0)-arrested human, WI-38 lung fibroblasts ( human, WI-38 cells). To determine the function of this protein in viral replication in these G0-arrested cells, we compared viral early mRNA, early protein, and late protein synthesis after infection with wild type or a mutant which does not express the protein. No differences were found. However, viral DNA synthesis by the mutant was delayed and decreased to 20 to 30% that of wild type in these cells. Viral DNA synthesis was much less defective in growing human, WI-38 cells, and in the transformed human, WI-38 HeLa cell line it occurred at wild-type levels. Furthermore, the mutant which can express only the 243- amino-acid early region 1A protein induced cellular DNA synthesis in G0-arrested rat cells to the same level as wild-type virus. A mutant which can express only the 289- amino-acid early region 1A protein induced less cellular DNA synthesis in G0-arrested rat cells. We propose that the early region 1A 243- amino-acid protein alters the physiology of arrested permissive cells to allow maximal viral DNA replication. In nonpermissive rodent cells, the 243- amino-acid protein drives G0-arrested cells into S phase. This activity is probably important for the immortalization of primary cells.
| null |
994_biomrc
|
Title: Clinical Correlates of Co-occurring Psychiatric and XXXX ( @entity72 ) Symptom-Induced Impairment in @entity1 with @entity72 .
UNASSIGNED: Although Children46 symptom severity and impairment are overlapping but nevertheless distinct illness parameters, little research has examined whether variables found to be associated with the severity are also correlated with symptom-induced impairment. Parents and teachers completed ratings of symptom-induced impairment and total number, impairment in social anxiety, impairment in any disorder, impairment for several disorders, impairment for DSM-IV-referenced syndromes , and parents completed a background questionnaire for a consecutively referred sample of primarily male (81 %) 6-to-12 year olds with ASD, autism spectrum disorder ( ASD, autism spectrum disorder ) (N = 221). Some clinical correlates (e.g., IQ < 70, maternal level of education, pregnancy complications, current use of psychotropic medication, season of birth) were associated with impairment and total number, impairment in social anxiety, impairment in any disorder, impairment for several disorders, impairment for DSM-IV-referenced syndromes , whereas others were correlated with only a few syndromes (e.g., gender, co-morbid medical conditions) or were not related to impairment and total number, impairment in social anxiety, impairment in any disorder, impairment for several disorders, impairment for DSM-IV-referenced syndromes (e.g., family psychopathology). There was little convergence in findings for parents' versus teachers' ratings. Some clinical correlates (e.g., season of birth, current psychotropic medication, maternal education) were unique predictors of three or more disorders. Pregnancy complications were uniquely associated with social Children48 and schizoid personality symptom-induced impairment. IQ was a unique predictor of Children61 , ASD, autism spectrum disorder , oppositional defiant disorder symptom-induced impairment. Children whose mothers had relatively fewer years of education had greater odds for symptom-induced impairment and total number, impairment in social anxiety, impairment in any disorder, impairment for several disorders, impairment for DSM-IV-referenced syndromes , depression , Children46 , and Children62 and greater number of impairing conditions. Season of birth was the most robust correlate of symptom-induced impairment as rated by teachers but not by parents. Children born in fall evidenced higher rates of co-occurring Children46 and ASD, autism spectrum disorder symptom-induced impairment and total number, impairment in social anxiety, impairment in any disorder, impairment for several disorders, impairment for DSM-IV-referenced syndromes of impairing conditions. Many variables previously linked with symptom severity are also correlated with impairment.
| null |
3046_biomrc
|
Title: Open balloon aortic valvuloplasty in XXXX : implications for transcatheter aortic valve implantations.
Balloon aortic valvuloplasty (BAV) plays a crucial role in transcatheter aortic valve implantation (TAVI). However, data on morphology during BAV are lacking. During surgical aortic valve replacement, open BAV was performed as a non-therapeutic in-vivo model prior to aortic valve excision. Twenty-six patients with severe aortic stenosis were included in the study after ethics committee approval. A valvuloplasty balloon was advanced from the open aorta, across the stenotic aortic valve and was rapidly inflated and deflated. All patients except for one had tricuspid aortic valves with severe visible calcification on the aortic side of leaflets. All valves were successfully dilated. Only in the presence of severe central calcific noduli, patients74 occurred in the middle portion of the leaflets in three and in the commissural part in four patients . No embolization of valvular debris occurred, however, ten coronary leaflets partially reached coronary orifices, resulting in three near-obstructions. The present study visualized for the first time the behaviour of bulky leaflet calcifications during valvuloplasty. patients74 in the middle portion of the free edge may occur whenever a huge calcification completely affects the whole leaflet area. No signs of embolization were observed, possibly explaining low stroke rates during TAVI procedures.
| null |
3047_biomrc
|
Title: Infliximab: a pharmacoeconomic review of its use in XXXX .
Infliximab (Remicade), a biological disease-modifying antirheumatic drug (DMARD), binds to and inhibits the activity of Tumour, tumour necrosis factor-alpha, which is thought to play an important role in the pathophysiology of Rheumatoid Arthritis, rheumatoid arthritis . Intravenous infliximab plus patients499 is recommended in patients with Rheumatoid Arthritis, rheumatoid arthritis who have not achieved satisfactory disease control with adequate courses of other DMARDs. Pharmacoeconomic analyses have been based on efficacy data from the pivotal placebo-controlled Anti- Tumour, tumour Necrosis Factor Trial in Rheumatoid Arthritis, rheumatoid arthritis with Concomitant Therapy (ATTRACT) trial in patients with active, refractory Rheumatoid Arthritis, rheumatoid arthritis . Infliximab every 8 weeks plus patients499 demonstrated rapid and sustainable improvements in clinical response, delayed radiographic progression, and/or improved functional status and health-related QOL compared with placebo plus patients499 at weeks 30, 54 and 102. In cost-utility analyses of infliximab plus patients499 conducted from a healthcare payer and/or societal perspective in the US, Europe, Portugal, Sweden and the UK, infliximab 3 mg/kg every 8 weeks plus patients499 was associated with acceptable (< US50,000 per discounted QALY gained) cost-utility ratios relative to patients499 alone in patients with active, refractory Rheumatoid Arthritis, rheumatoid arthritis . When only direct costs were considered, the lifetime incremental cost per discounted QALY gained with infliximab plus patients499 relative to patients499 alone was US30,500-38,700 (year of costing 1998 or not reported; treatment duration 54 or 102 weeks or lifelong) in the US and Europe analyses, and euro39 500 (year of costing not reported; lifelong treatment) in the Portuguese analysis. The cost-utility ratios were more favourable when lost productivity costs or the additional benefit of infliximab on radiographic stabilisation were considered. In the Swedish and UK analyses with a 10-year time horizon, infliximab plus patients499 for 1 or 2 years was associated with cost-utility ratios of euro28 600-56 100 (year of costing not reported) when direct costs were considered, and euro3440-48 200 when direct costs plus loss-of-productivity costs were considered. In conclusion, cost-utility analyses, which were based on modelling of data from the pivotal clinical trial of infliximab plus patients499 , indicate that infliximab plus patients499 is associated with acceptable cost-effectiveness ratios (< US50,000 per discounted QALY gained) relative to patients499 monotherapy in patients with active Rheumatoid Arthritis, rheumatoid arthritis who have not responded to previous patients499 or other DMARD therapy. The cost effectiveness of infliximab versus other DMARDs is at present unclear, but will be clarified when appropriate data from directly comparative clinical and/or pharmacoeconomic studies become available. In patients in whom adequate courses of other DMARDs have failed to achieve satisfactory disease control, infliximab plus patients499 may prevent or delay disability, which may produce reductions in nondrug costs that can help offset its acquisition cost.
| null |
998_biomrc
|
Title: Induced Pluripotent Stem Cell-Derived Natural Killer Cells for Treatment of XXXX .
UNASSIGNED: Natural killer (NK) cells can provide effective immunotherapy for ovarian cancer . Here, we evaluated the ability of NK cells isolated from peripheral blood (PB-) and NK cells derived from induced pluripotent stem cell (iPSC-) to mediate killing of ovarian cancer cells in a patients9 xenograft model. A patients9 xenograft model was used to evaluate the intraperitoneal delivery of three different NK cell populations: iPSC-derived NK cells, PB-NK cells that had been activated and expanded in long-term culture, and overnight activated PB-NK cells that were isolated through tumor168 / CD19 depletion of peripheral blood B and T cells. Bioluminescent imaging was used to monitor tumor burden of luciferase expressing tumor lines. Tumors were allowed to establish prior to administering NK cells via intraperitoneal injection. These studies demonstrate a single dose of any of the three NK cell populations significantly reduced tumor burden. When patients9 were given 3 doses of either iPSC-NK cells or expanded PB-NK cells, the median survival improved from 73 days in patients9 untreated to 98 and 97 days for treated patients9 , respectively. From these studies, we conclude iPSC-derived NK cells mediate anti- ovarian cancer killing at least as well as PB-NK cells, making these cells a viable resource for immunotherapy for ovarian cancer . Due to their ability to be easily differentiated into NK cells and their long-term expansion potential, iPSCs can be used to produce large numbers of well-defined NK cells that can be banked and used to treat a large number of patients including treatment with multiple doses if necessary. This article is protected by copyright. All rights reserved.
| null |
1001_biomrc
|
Title: HB Puerta del Sol [HBA1:c.148A>C], HB Valdecilla [ @entity13554 :c.3G>T], HB Gran V a [ @entity13554 :c.98T>G], HB Macarena [ @entity13554 :c.358C>T], and HB El Retiro [ XXXX :c.364_366dupGTG]: description of five new hemoglobinopathies.
BACKGROUND: Structural hemoglobinopathies do not usually have a clinical impact, but they can interfere with the analytical determination of some parameters, such as the glycated hemoglobin in diabetic patients . Thalassemias represent a serious health problem in areas where their incidence is high. The defects in the post-translational modifications produce hyper-unstable hemoglobin that is not detected by most of electrophoretic or chromatographic methods that are available so far. METHODS: We studied seven patients who belong to six unrelated families. The first two families were studied because they had peak abnormal hemoglobin (Hb) during routine analytical assays. The other four families were studied because they had microcytosis and hypochromia with normal patients3554 and HbF without iron deficiency. patients3554 and F quantification and abnormal Hb separation were performed by chromatographic and electrophoretic methods. The molecular characterization was performed using specific sequencing. RESULTS: The Hb Puerta del Sol presents electrophoretic mobility and elution in HPLC that is different from HbA and similar to HbS. The electrophoretic and chromatographic profiles of the four other variants are normal and do not show any anomalies, and their identification was only possible with sequencing. Conlcusions: Some variants, such as Hb Valdecilla, Hb Gran V a, Hb Macarena and Hb El Retiro, have significant clinical impact when they are associated with other forms of a-thalassemia, which could lead to more serious forms of this group of pathologies as for HbH disease. Therefore, it is important to maintain an adequate program for screening these diseases in countries where the prevalence is high to prevent the occurrence of severe forms.
| null |
1003_biomrc
|
Title: The Ghent Marfan Trial--a randomized, double-blind placebo controlled trial with XXXX in Marfan @entity1 treated with b-blockers.
BACKGROUND: Aortic root dilation , dissection and rupture are major clinical problems in children, Patients, human, patients614 ( children, Patients, human, patients614 ). Although b-blockers remain the standard of preventive treatment, preliminary results from animal studies and a selected group of severely affected children, Patients, human, patients614 children, Patients, human, patients show significant benefit from treatment with losartan , an angiotensin II receptor blocker with TGF-b inhibiting potential. Large-scale children, Patients, human, patients trials are now needed to confirm these results. This trial aims to evaluate the combined effect of both drugs. METHODS: We are conducting a prospective randomized placebo controlled double blind phase III study aiming to include 174 children, Patients, human, patients614 children, Patients, human, patients (age >= 10 years and z-score >= 2). children, Patients, human, patients already taking b-blockers are randomized for weight-adjusted treatment with losartan versus placebo. The primary endpoint is decrease in aortic root growth rate. Secondary endpoints are aortic dissection/surgery, progression of aortic/ mitral regurgitation , arterial stiffness , left ventricular systolic/diastolic function, quality of life and genetic modifiers. Echocardiography, vascular echo-Doppler and quality of life assessment will be performed at baseline and at 6-monthly follow-ups for 3 years. MRI evaluation will be performed at baseline and at the end of the trial. CONCLUSION: This trial will study new therapeutic strategies for the prevention of serious cardiovascular complications in children, Patients, human, patients614 . The uniqueness in our trial is that the additive effect of losartan and b-blocker will be evaluated in a large spectrum of disease severity. A combination of ultrasound and MRI will allow detailed evaluation of anatomic and functional properties of the aorta and left ventricle.
| null |
3056_biomrc
|
Title: Pelvic lymph node dissection in XXXX : indications, extent and tailored approaches.
PURPOSE: The purpose of this study is to review the current literature concerning the indication of pelvic lymph node dissection (PLND), its extent and complications in PCa, prostate cancer ( PCa, prostate cancer ) staging, the available tools, and the future perspectives to assess the risk of lymph node invasion (LNI). METHODS: A literature review was performed using the Medline, Embase, and Web of Science databases. The search strategy included the terms pelvic lymph nodes, PLND, radical prostatectomy, PCa, prostate cancer , lymph node invasion, biochemical recurrence, staging, sentinel lymph node dissection, imaging, and molecular markers. RESULTS: PLND currently represents the gold standard for nodal staging in PCa, prostate cancer patients, men . Available imaging techniques are characterized by poor accuracy in the prediction of LNI before surgery. On the contrary, an extended PLND (ePLND) would result into proper staging in the majority of the cases. Several models based on preoperative disease characteristics are available to assess the risk of LNI. Although ePLND is not associated with a substantial risk of severe complications, up to 10% of the patients, men undergoing this procedure experience lymphoceles. Concerns over potential morbidity of ePLND led many authors to investigate the role of sentinel lymph node dissection in order to prevent unnecessary ePLND. Finally, the incorporation of novel biomarkers in currently available tools would improve our ability to identify patients, men who should receive an ePLND. CONCLUSIONS: Nowadays, the most informative tools predicting LNI in PCa, prostate cancer patients, men consist in preoperative clinical nomograms. Sentinel lymph node dissection still remains experimental and novel biomarkers are needed to identify patients, men at a higher risk of LNI.
| null |
3057_biomrc
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Title: XXXX -- a safe and effective drug for termination of pregnancy.
In India, physicians analyzed data on 56 women (18-20 weeks gestation) at the Marie Stopes Clinic in Jodhpur who underwent pregnancy termination to evaluate the efficacy and safety of ethacriding lactate which has antiseptic properties. They injected 150 cc 0.1% ethacriding lactate into the intrauterine, extra-amniotic space. They used iv infusion of oxytocin to expedite the delivery of the abortus. 59% of cases were unmarried teenagers. women6972 induced successful abortion in 92.8% (52) of cases which was much higher than that found in the literature (about 82%). women77 occurred in the other 4 cases because of transverse lie of fetus (2), cervical women266 (1), and uterine inertia (1). The transverse lie and cervical women266 cases would have experienced failure regardless of the uterotonic abortifacient used. 3 of the failure cases underwent evacuation while the other underwent hysterotomy. Most women (73.2%) experienced the abortion 12-24 hours after induction. The mean interval was 20.1 house which was shorter than that of previous reports (29.5-38 hours). The shortest induction-abortion interval was 10.5 hours and the longest was more than 36 hours. Complications occurred in 6 (14.4%) cases. 3 (5.4%) women suffered from cervical tear. 3 (5.4%) women experienced incomplete expulsion which was much lower than that reported in the literature (16-30%). On the other hand, the 5.4% incomplete expulsion rate was higher than that for prostaglandin and hypertonic saline. There was 1 case each of severe bleeding and vaginal laceration . The antiseptic properties of women6972 likely accounted for the complete absence of sepsis in these women . In conclusion, women6972 performs better than other instillation abortion methods and it is a safe and effective method.
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3058_biomrc
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Title: Reversal of @entity1985 due to reactive amyloidosis (AA-type) after excision of localized XXXX .
The patient (TAL), a chronic asymptomatic HBV carrier with HBsAg-anti-HBsAg circulating immune complexes, was admitted to our hospital because of a patient985 due to patient2042 . There was no family history of patient4756 . Recurrent arthralgias , patient395 , and weight loss were the prominent clinical features. Laboratory test results showing that severe chronic inflammatory activity had been present for 6 years. IL-6, Interleukin-6 ( IL-6, Interleukin-6 ) serum concentration was 10 times normal and patient851 was 1.9 mg/ml. A complex immunological picture was also present (immune complex formation, exuberant B-cell reactivity, and decrease in the number of CD4 T cells). A localized form of patient2692 ( patient2692 ) (plasma-cell type) was diagnosed by surgical excision of a giant axillary lymph node. AA amyloid was present in the blood vessels. Within 60 days after excision of the mass, the systemic symptoms subsided, laboratory signs of inflammatory activity disappeared and IL-6, Interleukin-6 serum concentration returned to normal, thus establishing a causal relationship between the localized patient2692 , elevated IL-6, Interleukin-6 concentration and the chronic inflammation responsible for AA amyloidosis . At 10 months of follow-up, the patient985 has reversed, kidney function has slowly ameliorated, and the patient has gained 12 kg. Abdominal fat aspirates drawn to search for amyloid, positive before surgery, were subsequently negative. The latter finding, and the remission of the patient985 , provided strong evidence for regression of the amyloid deposits . However, the HBsAg-anti-HBsAg immune complexes and depression of T-helper cell activity persist. This immunological derangement is therefore not a consequence of patient2692 . Chronic stimulation of the immune system due to the patient 's inability to eliminate HBV , in the contest of perturbed immunity, may have favored the genesis of the lymphadenopathy.
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1008_biomrc
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Title: The "worth" of routine spirometry in a XXXX clinic.
In our patients577 clinic, all patients older than 6 years perform spirometry at each visit just before being seen by the health care team. Upon review, we determined that our perceived rationale for this practice was that the medical history fails to detect deterioration in a sizable minority of patients whose pulmonary decline can be detected by spirometry. Furthermore, the literature and our own experience indicates that physical examination frequently will not detect changes in pulmonary status until the changes are advanced. As part of an ongoing quality/cost assessment, we decided to challenge our rationale for performing routine spirometry. Using standard methodology, we developed a six-item Likert style questionnaire, the purpose of which was to assess perceived changes in pulmonary symptoms since the last clinic visit. The questionnaire had an acceptable degree of internal consistency (Cronbach's alpha = 0.92), although the question about sputum production showed the least correlation with responses to other items. We administered the questionnaire to 103 consecutive different patients and examined the association between reported changes in symptoms and actual changes in spirometric outcomes. Overall, there was a statistically significant, but clinically weak association between symptom scores and change in FEV1, r2 = 0.16, P < 0.001. Twenty-three patients had a decline in FEV1 of > or = 10% from one clinic visit to the next. Depending on the method used to place symptom scores into categories indicating that pulmonary symptoms were "worse," "same," or "better" than at the last clinic visit, 40-60% of these 23 patients indicated they felt the "same" or "better." We conclude that spirometry is a justifiable part of all clinic visits for patients with patients577 , assuming that one would want to detect and treat declines in pulmonary status before they become advanced.
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3063_biomrc
|
Title: A size selective vascular barrier in the XXXX area postrema formed by perivascular macrophages and the extracellular matrix.
The fenestrated microvasculature of the area postrema shows a less restrictive blood-brain barrier than is found in other areas of the CNS. We have studied the expression and relationship of vascular endothelial tight junctional proteins, astrocytes, macrophages, and the extracellular matrix with the extravasation of fluorescently tagged dextrans and sodium fluorescein in the rat area postrema. Glial fibrillary acidic protein, GFAP ( Glial fibrillary acidic protein, GFAP ) -positive astrocytes were present within the area postrema which was surrounded by a dense zone of highly Glial fibrillary acidic protein, GFAP -reactive astrocytes. Expression of the tight junction proteins claudin-5 , -12 and occludin was absent, although diffuse cytoplasmic claudin-1 immunoreactivity was present. The extracellular matrix of the endothelium showed two non-fused thickened layers of laminin immunoreactivity. CD163 and CD169 immunoreactive perivascular macrophages were located within lacunae between these two laminin layers. Fluorescently tagged dextrans (10-70 kDa) passed from the vasculature but were retained between the inner and outer laminin walls and rapidly sequestered by the perivascular CD163 and CD169 macrophages. Three-kilodalton dextran diffused into the parenchyma, but was retained within the boundary of the area postrema at the interface with the highly reactive Glial fibrillary acidic protein, GFAP -astrocytes, while sodium fluorescein (0.3 kDa) passed from the area postrema into surrounding CNS areas. Our observations suggest that despite the absence of a tight blood-brain barrier, a size selective barrier restricting the movement of blood solutes into the parenchyma is present in the area postrema. We suggest that the rapid uptake by CD163 and CD169 macrophages together with the non-fused laminin immunoreactive layers of the extracellular matrix plays a size selective role in restricting movement of serum proteins and other blood borne macromolecules over 10 kDa in to the area postrema.
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1021_biomrc
|
Title: Medication cost savings associated with @entity353 for XXXX non-insulin-dependent @entity6 @entity1 and @entity1 .
BACKGROUND: The cost of diabetes, diabetes mellitus can be defined in both medical and economic terms. Although there is an abundance of literature concerning the medical management of diabetes, diabetes mellitus , few studies have assessed the financial impact of its treatment. This study examined the savings in prescription costs associated with a weight reduction program for obese women, men and women, men with NIDDM, non-insulin-dependent diabetes mellitus ( NIDDM, non-insulin-dependent diabetes mellitus ). RESEARCH DESIGN AND METHODS: Forty subjects ages 40-70 years who had body mass indexes of 30-40 kg/m2 and NIDDM, non-insulin-dependent diabetes mellitus of more than 1 year duration were assigned to one of two 800-kcal weight-loss programs for 12 weeks. A cost analysis was done on the 32 subjects who were taking anti- women, men01 and/or anti- diabetes, diabetes mellitus medications. A list of medications and monthly amounts was obtained at the start, upon completion, and 1 year following completion of the diet. The average out-of-pocket cost for a month's supply of each prescription was calculated by polling 16 retail pharmacies in Lexington, Kentucky. RESULTS: Subjects lost an average of 15.3 kg (33.7 lb) over the 12 weeks. At 1-year follow-up, subjects maintained a mean 9.0-kg (19.8 lb) weight loss . The average monthly prediet out-of-pocket cost for anti- women, men01 and anti- diabetes, diabetes mellitus medications and supplies was 63.30 per subject. Following completion of the diet, this cost per month decreased to 20.40 and at 1-year follow-up the average monthly cost per subject was 32.40. The estimated average savings in prescription costs per subject over the year was 442.80. CONCLUSIONS: Significant short- and long-term savings in prescription costs were obtained following a 12-week hypocaloric weight reduction program for obese individuals with NIDDM, non-insulin-dependent diabetes mellitus .
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1026_biomrc
|
Title: 26Postoperative diagnosis and outcome in XXXX with revision arthroplasty for @entity1349 .
BACKGROUND: The most common cause of implant failure is Patients, patients, patient349 ( Patients, patients, patient349 ), followed by infection, prosthetic joint infection, PJI ( infection, prosthetic joint infection, PJI ). This study evaluates the incidence of infection, prosthetic joint infection, PJI among Patients, patients, patient operated with suspected Patients, patients, patient349 and whether the diagnosis of infection, prosthetic joint infection, PJI was predictive of subsequent implant failure including re- infection, prosthetic joint infection, PJI , at 2 years of follow up. METHODS: Patients, patients, patient undergoing revision hip or knee arthroplasty due to presumed Patients, patients, patient349 from February 2009 to September 2011 were prospectively evaluated. A sonication fluid of prosthesis and tissue samples for microbiology and histopathology at the time of the surgery were collected. Implant failure include recurrent or persistent infection, prosthetic joint infection, PJI , reoperation for any reason or need for chronic antibiotic suppression. RESULTS: Of 198 Patients, patients, patient with pre-and intraoperative diagnosis of Patients, patients, patient349 , 24 (12.1 %) had postoperative diagnosis of infection, prosthetic joint infection, PJI . After a follow up of 31 months (IQR: 21 to 38 months), 9 (37.5 %) of 24 Patients, patients, patient in the infection, prosthetic joint infection, PJI group had implant failure compared to only 1 (1.1 %) in the 198 of Patients, patients, patient349 group (p < 0.0001). Sensitivity of sonicate fluid culture (>20 CFU) and peri-prosthetic tissue culture were 87.5 % vs 66.7 %, respectively. Specificities were 100 % for both techniques (95 % CI, 97.9-100 %). A greater number of Patients, patients, patient with infection, prosthetic joint infection, PJI (79.1 %) had previous partial arthroplasty revisions than those Patients, patients, patient in the Patients, patients, patient349 group (56.9 %) (p = 0.04). In addition, 5 (55.5 %) Patients, patients, patient with infection, prosthetic joint infection, PJI and implant failure had more revision arthroplasties during the first year after the last implant placement than those Patients, patients, patient with infection, prosthetic joint infection, PJI without implant failure (1 Patients, patients, patient ; 6.7 %) (RR 3.8; 95 % CI 1.4-10.1; p = 0.015). On the other hand, 6 (25 %) Patients, patients, patient finally diagnosed of infection, prosthetic joint infection, PJI were initially diagnosed of Patients, patients, patient349 in the first year after primary arthroplasty, whereas it was only 16 (9.2 %) Patients, patients, patient in the group of true Patients, patients, patient349 (RR 2.7; 95 % CI 1.2-6.1; p = 0.03). CONCLUSIONS: More than one tenth of Patients, patients, patient with suspected Patients, patients, patient349 are misdiagnosed infection, prosthetic joint infection, PJI . Positive histology and positive peri-implant tissue and sonicate fluid cultures are highly predictive of implant failure in Patients, patients, patient with infection, prosthetic joint infection, PJI . Patients, patients, patient with greater number of partial hip revisions for a presumed Patients, patients, patient349 had more risk of infection, prosthetic joint infection, PJI . Early loosening is more often caused by hidden infection, prosthetic joint infection, PJI than late loosening.
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