bio-datasets/bigbio-ner-merged · Datasets at Hugging Face

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Glaukompatienten is an umlsterm, Tomographie is an umlsterm, Nervenfaserschicht is an umlsterm, Methoden is an umlsterm, Nervenfaserfotografie is an umlsterm, Gesichtsfeldbefunden is an umlsterm, Augen is an umlsterm, Patienten is an umlsterm, Offenwinkelglaukom is an umlsterm, Glaukomverdacht is an umlsterm, Nervenfaserschichtdicke is an umlsterm, Papillenpol is an umlsterm, Beurteilung is an umlsterm, Nervenfaserschicht is an umlsterm, Gesichtsfeldparametern is an umlsterm, Nervenfaserschicht is an umlsterm, Gesichtsfeldveraenderungen is an umlsterm, Nervenfaserschichtbefunde is an umlsterm, Erweiterung is an umlsterm, Pupille is an umlsterm	DerOpthalmologe.60930520.ger.abstr_task1	Sentence: Beim Glaukompatienten bestehen klinisch eindeutige Zusammenhaenge zwischen morphologischen und funktionellen Veraenderungen . Die neuen Scanning-Laser-Ophthalmoskope zur Tomographie der Papille und Polarimetrie der Nervenfaserschicht sollten gegenueber klinischen Methoden objektivere Daten und damit bessere Korrelationen ermoeglichen . In einer Querschnittsstudie wurden die Ergebnisse der konventionellen Papillen- und Nervenfaserfotografie , die Stereoplanimetrie , der Laser-Scanning-Tomographie ( TopSS und Polarimetrie ( ) Nerve Fiber Analyzer ) mit den Gesichtsfeldbefunden Octopus-Programm G 1 ) korreliert . Es wurden 157 Augen von 157 Patienten mit manifestem Offenwinkelglaukom sowie Glaukomverdacht untersucht . Von den polarimetrischen Parametern korreliert die Modulation der Nervenfaserschichtdicke ( Maximum - Minimum ) am besten mit der mittleren Sensitivitaet ( r2 = 0,23 ) . Von den tomographischen Parametern korrelierte die neuroretinale Randzone am oberen und unteren Papillenpol am besten mit der Verlustvarianz ( LV ) ( r2 = 0,20 ) . Die planimetrischen Papillenparameter sowie die klinische Beurteilung der Nervenfaserschicht korrelierten geringfuegig besser mit den Gesichtsfeldparametern als die Daten der Scanning-Laser-Tomographie oder Polarimetrie . Die Parameter der Nervenfaserschicht sind zwar schwieriger zu erfassen , korrelieren jedoch generell besser mit den diffusen Gesichtsfeldveraenderungen als die Papillenparameter . Die neuen Scanning-Laser-Verfahren verbessern die Korrelationen nicht , ermoeglichen jedoch eine objektive Erfassung der Papillen- und Nervenfaserschichtbefunde ohne Erweiterung der Pupille . Instructions: please typing these entity words according to sentence: Glaukompatienten, Tomographie, Nervenfaserschicht, Methoden, Nervenfaserfotografie, Gesichtsfeldbefunden, Augen, Patienten, Offenwinkelglaukom, Glaukomverdacht, Nervenfaserschichtdicke, Papillenpol, Beurteilung, Nervenfaserschicht, Gesichtsfeldparametern, Nervenfaserschicht, Gesichtsfeldveraenderungen, Nervenfaserschichtbefunde, Erweiterung, Pupille Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O" ]	Beim Glaukompatienten bestehen klinisch eindeutige Zusammenhaenge zwischen morphologischen und funktionellen Veraenderungen . Die neuen Scanning-Laser-Ophthalmoskope zur Tomographie der Papille und Polarimetrie der Nervenfaserschicht sollten gegenueber klinischen Methoden objektivere Daten und damit bessere Korrelationen ermoeglichen . In einer Querschnittsstudie wurden die Ergebnisse der konventionellen Papillen- und Nervenfaserfotografie , die Stereoplanimetrie , der Laser-Scanning-Tomographie ( TopSS und Polarimetrie ( ) Nerve Fiber Analyzer ) mit den Gesichtsfeldbefunden Octopus-Programm G 1 ) korreliert . Es wurden 157 Augen von 157 Patienten mit manifestem Offenwinkelglaukom sowie Glaukomverdacht untersucht . Von den polarimetrischen Parametern korreliert die Modulation der Nervenfaserschichtdicke ( Maximum - Minimum ) am besten mit der mittleren Sensitivitaet ( r2 = 0,23 ) . Von den tomographischen Parametern korrelierte die neuroretinale Randzone am oberen und unteren Papillenpol am besten mit der Verlustvarianz ( LV ) ( r2 = 0,20 ) . Die planimetrischen Papillenparameter sowie die klinische Beurteilung der Nervenfaserschicht korrelierten geringfuegig besser mit den Gesichtsfeldparametern als die Daten der Scanning-Laser-Tomographie oder Polarimetrie . Die Parameter der Nervenfaserschicht sind zwar schwieriger zu erfassen , korrelieren jedoch generell besser mit den diffusen Gesichtsfeldveraenderungen als die Papillenparameter . Die neuen Scanning-Laser-Verfahren verbessern die Korrelationen nicht , ermoeglichen jedoch eine objektive Erfassung der Papillen- und Nervenfaserschichtbefunde ohne Erweiterung der Pupille .	[ "Beim", "Glaukompatienten", "bestehen", "klinisch", "eindeutige", "Zusammenhaenge", "zwischen", "morphologischen", "und", "funktionellen", "Veraenderungen", ".", "Die", "neuen", "Scanning", "-", "Laser", "-", "Ophthalmoskope", "zur", "Tomographie", "der", "Papille", "und", "Polarimetrie", "der", "Nervenfaserschicht", "sollten", "gegenueber", "klinischen", "Methoden", "objektivere", "Daten", "und", "damit", "bessere", "Korrelationen", "ermoeglichen", ".", "In", "einer", "Querschnittsstudie", "wurden", "die", "Ergebnisse", "der", "konventionellen", "Papillen-", "und", "Nervenfaserfotografie", ",", "die", "Stereoplanimetrie", ",", "der", "Laser", "-", "Scanning", "-", "Tomographie", "(", "TopSS", "und", "Polarimetrie", "(", ")", "Nerve", "Fiber", "Analyzer", ")", "mit", "den", "Gesichtsfeldbefunden", "Octopus", "-", "Programm", "G", "1", ")", "korreliert", ".", "Es", "wurden", "157", "Augen", "von", "157", "Patienten", "mit", "manifestem", "Offenwinkelglaukom", "sowie", "Glaukomverdacht", "untersucht", ".", "Von", "den", "polarimetrischen", "Parametern", "korreliert", "die", "Modulation", "der", "Nervenfaserschichtdicke", "(", "Maximum", "-", "Minimum", ")", "am", "besten", "mit", "der", "mittleren", "Sensitivitaet", "(", "r2", "=", "0,23", ")", ".", "Von", "den", "tomographischen", "Parametern", "korrelierte", "die", "neuroretinale", "Randzone", "am", "oberen", "und", "unteren", "Papillenpol", "am", "besten", "mit", "der", "Verlustvarianz", "(", "LV", ")", "(", "r2", "=", "0,20", ")", ".", "Die", "planimetrischen", "Papillenparameter", "sowie", "die", "klinische", "Beurteilung", "der", "Nervenfaserschicht", "korrelierten", "geringfuegig", "besser", "mit", "den", "Gesichtsfeldparametern", "als", "die", "Daten", "der", "Scanning", "-", "Laser", "-", "Tomographie", "oder", "Polarimetrie", ".", "Die", "Parameter", "der", "Nervenfaserschicht", "sind", "zwar", "schwieriger", "zu", "erfassen", ",", "korrelieren", "jedoch", "generell", "besser", "mit", "den", "diffusen", "Gesichtsfeldveraenderungen", "als", "die", "Papillenparameter", ".", "Die", "neuen", "Scanning", "-", "Laser", "-", "Verfahren", "verbessern", "die", "Korrelationen", "nicht", ",", "ermoeglichen", "jedoch", "eine", "objektive", "Erfassung", "der", "Papillen-", "und", "Nervenfaserschichtbefunde", "ohne", "Erweiterung", "der", "Pupille", "." ]	[ "umlsterm" ]
Glaukompatienten, Tomographie, Nervenfaserschicht, Methoden, Nervenfaserfotografie, Gesichtsfeldbefunden, Augen, Patienten, Offenwinkelglaukom, Glaukomverdacht, Nervenfaserschichtdicke, Papillenpol, Beurteilung, Nervenfaserschicht, Gesichtsfeldparametern, Nervenfaserschicht, Gesichtsfeldveraenderungen, Nervenfaserschichtbefunde, Erweiterung, Pupille	DerOpthalmologe.60930520.ger.abstr_task2	Sentence: Beim Glaukompatienten bestehen klinisch eindeutige Zusammenhaenge zwischen morphologischen und funktionellen Veraenderungen . Die neuen Scanning-Laser-Ophthalmoskope zur Tomographie der Papille und Polarimetrie der Nervenfaserschicht sollten gegenueber klinischen Methoden objektivere Daten und damit bessere Korrelationen ermoeglichen . In einer Querschnittsstudie wurden die Ergebnisse der konventionellen Papillen- und Nervenfaserfotografie , die Stereoplanimetrie , der Laser-Scanning-Tomographie ( TopSS und Polarimetrie ( ) Nerve Fiber Analyzer ) mit den Gesichtsfeldbefunden Octopus-Programm G 1 ) korreliert . Es wurden 157 Augen von 157 Patienten mit manifestem Offenwinkelglaukom sowie Glaukomverdacht untersucht . Von den polarimetrischen Parametern korreliert die Modulation der Nervenfaserschichtdicke ( Maximum - Minimum ) am besten mit der mittleren Sensitivitaet ( r2 = 0,23 ) . Von den tomographischen Parametern korrelierte die neuroretinale Randzone am oberen und unteren Papillenpol am besten mit der Verlustvarianz ( LV ) ( r2 = 0,20 ) . Die planimetrischen Papillenparameter sowie die klinische Beurteilung der Nervenfaserschicht korrelierten geringfuegig besser mit den Gesichtsfeldparametern als die Daten der Scanning-Laser-Tomographie oder Polarimetrie . Die Parameter der Nervenfaserschicht sind zwar schwieriger zu erfassen , korrelieren jedoch generell besser mit den diffusen Gesichtsfeldveraenderungen als die Papillenparameter . Die neuen Scanning-Laser-Verfahren verbessern die Korrelationen nicht , ermoeglichen jedoch eine objektive Erfassung der Papillen- und Nervenfaserschichtbefunde ohne Erweiterung der Pupille . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O" ]	Beim Glaukompatienten bestehen klinisch eindeutige Zusammenhaenge zwischen morphologischen und funktionellen Veraenderungen . Die neuen Scanning-Laser-Ophthalmoskope zur Tomographie der Papille und Polarimetrie der Nervenfaserschicht sollten gegenueber klinischen Methoden objektivere Daten und damit bessere Korrelationen ermoeglichen . In einer Querschnittsstudie wurden die Ergebnisse der konventionellen Papillen- und Nervenfaserfotografie , die Stereoplanimetrie , der Laser-Scanning-Tomographie ( TopSS und Polarimetrie ( ) Nerve Fiber Analyzer ) mit den Gesichtsfeldbefunden Octopus-Programm G 1 ) korreliert . Es wurden 157 Augen von 157 Patienten mit manifestem Offenwinkelglaukom sowie Glaukomverdacht untersucht . Von den polarimetrischen Parametern korreliert die Modulation der Nervenfaserschichtdicke ( Maximum - Minimum ) am besten mit der mittleren Sensitivitaet ( r2 = 0,23 ) . Von den tomographischen Parametern korrelierte die neuroretinale Randzone am oberen und unteren Papillenpol am besten mit der Verlustvarianz ( LV ) ( r2 = 0,20 ) . Die planimetrischen Papillenparameter sowie die klinische Beurteilung der Nervenfaserschicht korrelierten geringfuegig besser mit den Gesichtsfeldparametern als die Daten der Scanning-Laser-Tomographie oder Polarimetrie . Die Parameter der Nervenfaserschicht sind zwar schwieriger zu erfassen , korrelieren jedoch generell besser mit den diffusen Gesichtsfeldveraenderungen als die Papillenparameter . Die neuen Scanning-Laser-Verfahren verbessern die Korrelationen nicht , ermoeglichen jedoch eine objektive Erfassung der Papillen- und Nervenfaserschichtbefunde ohne Erweiterung der Pupille .	[ "Beim", "Glaukompatienten", "bestehen", "klinisch", "eindeutige", "Zusammenhaenge", "zwischen", "morphologischen", "und", "funktionellen", "Veraenderungen", ".", "Die", "neuen", "Scanning", "-", "Laser", "-", "Ophthalmoskope", "zur", "Tomographie", "der", "Papille", "und", "Polarimetrie", "der", "Nervenfaserschicht", "sollten", "gegenueber", "klinischen", "Methoden", "objektivere", "Daten", "und", "damit", "bessere", "Korrelationen", "ermoeglichen", ".", "In", "einer", "Querschnittsstudie", "wurden", "die", "Ergebnisse", "der", "konventionellen", "Papillen-", "und", "Nervenfaserfotografie", ",", "die", "Stereoplanimetrie", ",", "der", "Laser", "-", "Scanning", "-", "Tomographie", "(", "TopSS", "und", "Polarimetrie", "(", ")", "Nerve", "Fiber", "Analyzer", ")", "mit", "den", "Gesichtsfeldbefunden", "Octopus", "-", "Programm", "G", "1", ")", "korreliert", ".", "Es", "wurden", "157", "Augen", "von", "157", "Patienten", "mit", "manifestem", "Offenwinkelglaukom", "sowie", "Glaukomverdacht", "untersucht", ".", "Von", "den", "polarimetrischen", "Parametern", "korreliert", "die", "Modulation", "der", "Nervenfaserschichtdicke", "(", "Maximum", "-", "Minimum", ")", "am", "besten", "mit", "der", "mittleren", "Sensitivitaet", "(", "r2", "=", "0,23", ")", ".", "Von", "den", "tomographischen", "Parametern", "korrelierte", "die", "neuroretinale", "Randzone", "am", "oberen", "und", "unteren", "Papillenpol", "am", "besten", "mit", "der", "Verlustvarianz", "(", "LV", ")", "(", "r2", "=", "0,20", ")", ".", "Die", "planimetrischen", "Papillenparameter", "sowie", "die", "klinische", "Beurteilung", "der", "Nervenfaserschicht", "korrelierten", "geringfuegig", "besser", "mit", "den", "Gesichtsfeldparametern", "als", "die", "Daten", "der", "Scanning", "-", "Laser", "-", "Tomographie", "oder", "Polarimetrie", ".", "Die", "Parameter", "der", "Nervenfaserschicht", "sind", "zwar", "schwieriger", "zu", "erfassen", ",", "korrelieren", "jedoch", "generell", "besser", "mit", "den", "diffusen", "Gesichtsfeldveraenderungen", "als", "die", "Papillenparameter", ".", "Die", "neuen", "Scanning", "-", "Laser", "-", "Verfahren", "verbessern", "die", "Korrelationen", "nicht", ",", "ermoeglichen", "jedoch", "eine", "objektive", "Erfassung", "der", "Papillen-", "und", "Nervenfaserschichtbefunde", "ohne", "Erweiterung", "der", "Pupille", "." ]	[ "umlsterm" ]
liver abscess is an umlsterm, disease is an umlsterm, man is an umlsterm, liver abscess is an umlsterm, pleural empyema is an umlsterm, trauma is an umlsterm, patient is an umlsterm, therapy is an umlsterm, hepatectomy is an umlsterm, pleural is an umlsterm, drainage is an umlsterm, signs is an umlsterm, diagnosis is an umlsterm, therapy is an umlsterm, case report is an umlsterm	DerChirurg.80690985.eng.abstr_task0	Sentence: Post-traumatic pyogenic liver abscess is a rare disease . We present the case of a 38-year-old man with multilocular liver abscess and pleural empyema following blunt abdominal trauma . The patient had a prodrome lasting 3 months before presenting in our department . The therapy included partial hepatectomy and pleural drainage . Clinical signs , diagnosis and possible therapy are discussed in this case report . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]	Post-traumatic pyogenic liver abscess is a rare disease . We present the case of a 38-year-old man with multilocular liver abscess and pleural empyema following blunt abdominal trauma . The patient had a prodrome lasting 3 months before presenting in our department . The therapy included partial hepatectomy and pleural drainage . Clinical signs , diagnosis and possible therapy are discussed in this case report .	[ "Post", "-", "traumatic", "pyogenic", "liver", "abscess", "is", "a", "rare", "disease", ".", "We", "present", "the", "case", "of", "a", "38-year", "-", "old", "man", "with", "multilocular", "liver", "abscess", "and", "pleural", "empyema", "following", "blunt", "abdominal", "trauma", ".", "The", "patient", "had", "a", "prodrome", "lasting", "3", "months", "before", "presenting", "in", "our", "department", ".", "The", "therapy", "included", "partial", "hepatectomy", "and", "pleural", "drainage", ".", "Clinical", "signs", ",", "diagnosis", "and", "possible", "therapy", "are", "discussed", "in", "this", "case", "report", "." ]	[ "umlsterm" ]
liver abscess is an umlsterm, disease is an umlsterm, man is an umlsterm, liver abscess is an umlsterm, pleural empyema is an umlsterm, trauma is an umlsterm, patient is an umlsterm, therapy is an umlsterm, hepatectomy is an umlsterm, pleural is an umlsterm, drainage is an umlsterm, signs is an umlsterm, diagnosis is an umlsterm, therapy is an umlsterm, case report is an umlsterm	DerChirurg.80690985.eng.abstr_task1	Sentence: Post-traumatic pyogenic liver abscess is a rare disease . We present the case of a 38-year-old man with multilocular liver abscess and pleural empyema following blunt abdominal trauma . The patient had a prodrome lasting 3 months before presenting in our department . The therapy included partial hepatectomy and pleural drainage . Clinical signs , diagnosis and possible therapy are discussed in this case report . Instructions: please typing these entity words according to sentence: liver abscess, disease, man, liver abscess, pleural empyema, trauma, patient, therapy, hepatectomy, pleural, drainage, signs, diagnosis, therapy, case report Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]	Post-traumatic pyogenic liver abscess is a rare disease . We present the case of a 38-year-old man with multilocular liver abscess and pleural empyema following blunt abdominal trauma . The patient had a prodrome lasting 3 months before presenting in our department . The therapy included partial hepatectomy and pleural drainage . Clinical signs , diagnosis and possible therapy are discussed in this case report .	[ "Post", "-", "traumatic", "pyogenic", "liver", "abscess", "is", "a", "rare", "disease", ".", "We", "present", "the", "case", "of", "a", "38-year", "-", "old", "man", "with", "multilocular", "liver", "abscess", "and", "pleural", "empyema", "following", "blunt", "abdominal", "trauma", ".", "The", "patient", "had", "a", "prodrome", "lasting", "3", "months", "before", "presenting", "in", "our", "department", ".", "The", "therapy", "included", "partial", "hepatectomy", "and", "pleural", "drainage", ".", "Clinical", "signs", ",", "diagnosis", "and", "possible", "therapy", "are", "discussed", "in", "this", "case", "report", "." ]	[ "umlsterm" ]
liver abscess, disease, man, liver abscess, pleural empyema, trauma, patient, therapy, hepatectomy, pleural, drainage, signs, diagnosis, therapy, case report	DerChirurg.80690985.eng.abstr_task2	Sentence: Post-traumatic pyogenic liver abscess is a rare disease . We present the case of a 38-year-old man with multilocular liver abscess and pleural empyema following blunt abdominal trauma . The patient had a prodrome lasting 3 months before presenting in our department . The therapy included partial hepatectomy and pleural drainage . Clinical signs , diagnosis and possible therapy are discussed in this case report . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]	Post-traumatic pyogenic liver abscess is a rare disease . We present the case of a 38-year-old man with multilocular liver abscess and pleural empyema following blunt abdominal trauma . The patient had a prodrome lasting 3 months before presenting in our department . The therapy included partial hepatectomy and pleural drainage . Clinical signs , diagnosis and possible therapy are discussed in this case report .	[ "Post", "-", "traumatic", "pyogenic", "liver", "abscess", "is", "a", "rare", "disease", ".", "We", "present", "the", "case", "of", "a", "38-year", "-", "old", "man", "with", "multilocular", "liver", "abscess", "and", "pleural", "empyema", "following", "blunt", "abdominal", "trauma", ".", "The", "patient", "had", "a", "prodrome", "lasting", "3", "months", "before", "presenting", "in", "our", "department", ".", "The", "therapy", "included", "partial", "hepatectomy", "and", "pleural", "drainage", ".", "Clinical", "signs", ",", "diagnosis", "and", "possible", "therapy", "are", "discussed", "in", "this", "case", "report", "." ]	[ "umlsterm" ]
use is an umlsterm, propofol is an umlsterm, hypnosis is an umlsterm, children is an umlsterm, elder is an umlsterm, data reported is an umlsterm, literature is an umlsterm, pharmacokinetic is an umlsterm, propofol is an umlsterm, children is an umlsterm, use is an umlsterm, narcotic is an umlsterm, hypnotic is an umlsterm, diagnostic is an umlsterm, therapeutic is an umlsterm	DerAnaesthesist.80470229.eng.abstr_task0	Sentence: Since its introduction in clinical use more than ten years ago , propofol is well appreciated for sedation and supplemental hypnosis in anaesthesia . However the substance is approved only for anaesthesia in children elder than three years . As can be substantiated by many data reported in literature , there are no pharmacokinetic or pharmacodynamic reasons whatsoever to withhold propofol from the younger children ; this applies both to the use as a narcotic supplement and as a short term hypnotic for diagnostic and therapeutic interventions . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O" ]	Since its introduction in clinical use more than ten years ago , propofol is well appreciated for sedation and supplemental hypnosis in anaesthesia . However the substance is approved only for anaesthesia in children elder than three years . As can be substantiated by many data reported in literature , there are no pharmacokinetic or pharmacodynamic reasons whatsoever to withhold propofol from the younger children ; this applies both to the use as a narcotic supplement and as a short term hypnotic for diagnostic and therapeutic interventions .	[ "Since", "its", "introduction", "in", "clinical", "use", "more", "than", "ten", "years", "ago", ",", "propofol", "is", "well", "appreciated", "for", "sedation", "and", "supplemental", "hypnosis", "in", "anaesthesia", ".", "However", "the", "substance", "is", "approved", "only", "for", "anaesthesia", "in", "children", "elder", "than", "three", "years", ".", "As", "can", "be", "substantiated", "by", "many", "data", "reported", "in", "literature", ",", "there", "are", "no", "pharmacokinetic", "or", "pharmacodynamic", "reasons", "whatsoever", "to", "withhold", "propofol", "from", "the", "younger", "children", ";", "this", "applies", "both", "to", "the", "use", "as", "a", "narcotic", "supplement", "and", "as", "a", "short", "term", "hypnotic", "for", "diagnostic", "and", "therapeutic", "interventions", "." ]	[ "umlsterm" ]
use is an umlsterm, propofol is an umlsterm, hypnosis is an umlsterm, children is an umlsterm, elder is an umlsterm, data reported is an umlsterm, literature is an umlsterm, pharmacokinetic is an umlsterm, propofol is an umlsterm, children is an umlsterm, use is an umlsterm, narcotic is an umlsterm, hypnotic is an umlsterm, diagnostic is an umlsterm, therapeutic is an umlsterm	DerAnaesthesist.80470229.eng.abstr_task1	Sentence: Since its introduction in clinical use more than ten years ago , propofol is well appreciated for sedation and supplemental hypnosis in anaesthesia . However the substance is approved only for anaesthesia in children elder than three years . As can be substantiated by many data reported in literature , there are no pharmacokinetic or pharmacodynamic reasons whatsoever to withhold propofol from the younger children ; this applies both to the use as a narcotic supplement and as a short term hypnotic for diagnostic and therapeutic interventions . Instructions: please typing these entity words according to sentence: use, propofol, hypnosis, children, elder, data reported, literature, pharmacokinetic, propofol, children, use, narcotic, hypnotic, diagnostic, therapeutic Options: umlsterm	[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O" ]	Since its introduction in clinical use more than ten years ago , propofol is well appreciated for sedation and supplemental hypnosis in anaesthesia . However the substance is approved only for anaesthesia in children elder than three years . As can be substantiated by many data reported in literature , there are no pharmacokinetic or pharmacodynamic reasons whatsoever to withhold propofol from the younger children ; this applies both to the use as a narcotic supplement and as a short term hypnotic for diagnostic and therapeutic interventions .	[ "Since", "its", "introduction", "in", "clinical", "use", "more", "than", "ten", "years", "ago", ",", "propofol", "is", "well", "appreciated", "for", "sedation", "and", "supplemental", "hypnosis", "in", "anaesthesia", ".", "However", "the", "substance", "is", "approved", "only", "for", "anaesthesia", "in", "children", "elder", "than", "three", "years", ".", "As", "can", "be", "substantiated", "by", "many", "data", "reported", "in", "literature", ",", "there", "are", "no", "pharmacokinetic", "or", "pharmacodynamic", "reasons", "whatsoever", "to", "withhold", "propofol", "from", "the", "younger", "children", ";", "this", "applies", "both", "to", "the", "use", "as", "a", "narcotic", "supplement", "and", "as", "a", "short", "term", "hypnotic", "for", "diagnostic", "and", "therapeutic", "interventions", "." ]	[ "umlsterm" ]
use, propofol, hypnosis, children, elder, data reported, literature, pharmacokinetic, propofol, children, use, narcotic, hypnotic, diagnostic, therapeutic	DerAnaesthesist.80470229.eng.abstr_task2	Sentence: Since its introduction in clinical use more than ten years ago , propofol is well appreciated for sedation and supplemental hypnosis in anaesthesia . However the substance is approved only for anaesthesia in children elder than three years . As can be substantiated by many data reported in literature , there are no pharmacokinetic or pharmacodynamic reasons whatsoever to withhold propofol from the younger children ; this applies both to the use as a narcotic supplement and as a short term hypnotic for diagnostic and therapeutic interventions . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O" ]	Since its introduction in clinical use more than ten years ago , propofol is well appreciated for sedation and supplemental hypnosis in anaesthesia . However the substance is approved only for anaesthesia in children elder than three years . As can be substantiated by many data reported in literature , there are no pharmacokinetic or pharmacodynamic reasons whatsoever to withhold propofol from the younger children ; this applies both to the use as a narcotic supplement and as a short term hypnotic for diagnostic and therapeutic interventions .	[ "Since", "its", "introduction", "in", "clinical", "use", "more", "than", "ten", "years", "ago", ",", "propofol", "is", "well", "appreciated", "for", "sedation", "and", "supplemental", "hypnosis", "in", "anaesthesia", ".", "However", "the", "substance", "is", "approved", "only", "for", "anaesthesia", "in", "children", "elder", "than", "three", "years", ".", "As", "can", "be", "substantiated", "by", "many", "data", "reported", "in", "literature", ",", "there", "are", "no", "pharmacokinetic", "or", "pharmacodynamic", "reasons", "whatsoever", "to", "withhold", "propofol", "from", "the", "younger", "children", ";", "this", "applies", "both", "to", "the", "use", "as", "a", "narcotic", "supplement", "and", "as", "a", "short", "term", "hypnotic", "for", "diagnostic", "and", "therapeutic", "interventions", "." ]	[ "umlsterm" ]
ADF/ cofilin is a protein-family, actin is a protein-family	1.0alpha7.train.93_task0	Sentence: ADF/ cofilin can directly bind to actin filaments and promote their disassembly (Carlier et al., 1999 ; Bamburg, 1999 ). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: protein-family	[ "B-protein-family", "I-protein-family", "O", "O", "O", "O", "B-protein-family", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	ADF/ cofilin can directly bind to actin filaments and promote their disassembly (Carlier et al., 1999 ; Bamburg, 1999 ).	[ "ADF/", "cofilin", "can", "directly", "bind", "to", "actin", "filaments", "and", "promote", "their", "disassembly", "(", "Carlier", "et", "al", ".", ",", "1999", ";", "Bamburg", ",", "1999", ")", "." ]	[ "protein-family" ]
ADF/ cofilin is a protein-family, actin is a protein-family	1.0alpha7.train.93_task1	Sentence: ADF/ cofilin can directly bind to actin filaments and promote their disassembly (Carlier et al., 1999 ; Bamburg, 1999 ). Instructions: please typing these entity words according to sentence: ADF/ cofilin, actin Options: protein-family	[ "B-protein-family", "I-protein-family", "O", "O", "O", "O", "B-protein-family", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	ADF/ cofilin can directly bind to actin filaments and promote their disassembly (Carlier et al., 1999 ; Bamburg, 1999 ).	[ "ADF/", "cofilin", "can", "directly", "bind", "to", "actin", "filaments", "and", "promote", "their", "disassembly", "(", "Carlier", "et", "al", ".", ",", "1999", ";", "Bamburg", ",", "1999", ")", "." ]	[ "protein-family" ]
ADF/ cofilin, actin	1.0alpha7.train.93_task2	Sentence: ADF/ cofilin can directly bind to actin filaments and promote their disassembly (Carlier et al., 1999 ; Bamburg, 1999 ). Instructions: please extract entity words from the input sentence	[ "B-protein-family", "I-protein-family", "O", "O", "O", "O", "B-protein-family", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	ADF/ cofilin can directly bind to actin filaments and promote their disassembly (Carlier et al., 1999 ; Bamburg, 1999 ).	[ "ADF/", "cofilin", "can", "directly", "bind", "to", "actin", "filaments", "and", "promote", "their", "disassembly", "(", "Carlier", "et", "al", ".", ",", "1999", ";", "Bamburg", ",", "1999", ")", "." ]	[ "protein-family" ]
time is an umlsterm, chorea is an umlsterm, tics is an umlsterm, syndrome is an umlsterm, Tics is an umlsterm, symptoms is an umlsterm, chorea is an umlsterm, symptoms is an umlsterm, children is an umlsterm, symptoms is an umlsterm, signs is an umlsterm, treatment is an umlsterm, diagnostic is an umlsterm, criteria is an umlsterm, susceptibility is an umlsterm, antibody is an umlsterm, antigens is an umlsterm, immunoglobulins is an umlsterm, therapy is an umlsterm, motor tics is an umlsterm, vocal tics is an umlsterm, behavioral symptoms is an umlsterm, control is an umlsterm, findings is an umlsterm, therapy is an umlsterm, literature is an umlsterm	DerNervenarzt.70680914.eng.abstr_task0	Sentence: It has known for a long time that Sydenham's chorea and tics , as seen in Gilles de la Tourette's syndrome ( GTS ) , are phenomenologically very similar . Tics may occur as symptoms of acute Sydenham's chorea or persist over years as residual symptoms . Investigations of children suffering from GTS , including obsessive-compusilve symptoms , have provided signs of a poststreptococcal autoimmune process but also shown that treatment based on immunological interventions has been effective . We treated a 14-year-old boy showing all diagnostic criteria of GTS , familial susceptibility , and an increase in the antibody titer of streptococcal antigens with 7S immunoglobulins i.v. over 5 days . Response to this therapy was good regarding motor tics , vocal tics , and behavioral symptoms such as disturbed impulse control which still persisted after 9 months . These findings and the successful therapy underline reports of the literature and point to a pathogenetic mechanism of an immunologically triggered disturbance of the striatal dopaminergic system , at least in a subgroup of GTS . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	It has known for a long time that Sydenham's chorea and tics , as seen in Gilles de la Tourette's syndrome ( GTS ) , are phenomenologically very similar . Tics may occur as symptoms of acute Sydenham's chorea or persist over years as residual symptoms . Investigations of children suffering from GTS , including obsessive-compusilve symptoms , have provided signs of a poststreptococcal autoimmune process but also shown that treatment based on immunological interventions has been effective . We treated a 14-year-old boy showing all diagnostic criteria of GTS , familial susceptibility , and an increase in the antibody titer of streptococcal antigens with 7S immunoglobulins i.v. over 5 days . Response to this therapy was good regarding motor tics , vocal tics , and behavioral symptoms such as disturbed impulse control which still persisted after 9 months . These findings and the successful therapy underline reports of the literature and point to a pathogenetic mechanism of an immunologically triggered disturbance of the striatal dopaminergic system , at least in a subgroup of GTS .	[ "It", "has", "known", "for", "a", "long", "time", "that", "Sydenham", "'s", "chorea", "and", "tics", ",", "as", "seen", "in", "Gilles", "de", "la", "Tourette", "'s", "syndrome", "(", "GTS", ")", ",", "are", "phenomenologically", "very", "similar", ".", "Tics", "may", "occur", "as", "symptoms", "of", "acute", "Sydenham", "'s", "chorea", "or", "persist", "over", "years", "as", "residual", "symptoms", ".", "Investigations", "of", "children", "suffering", "from", "GTS", ",", "including", "obsessive", "-", "compusilve", "symptoms", ",", "have", "provided", "signs", "of", "a", "poststreptococcal", "autoimmune", "process", "but", "also", "shown", "that", "treatment", "based", "on", "immunological", "interventions", "has", "been", "effective", ".", "We", "treated", "a", "14-year", "-", "old", "boy", "showing", "all", "diagnostic", "criteria", "of", "GTS", ",", "familial", "susceptibility", ",", "and", "an", "increase", "in", "the", "antibody", "titer", "of", "streptococcal", "antigens", "with", "7S", "immunoglobulins", "i.v", ".", "over", "5", "days", ".", "Response", "to", "this", "therapy", "was", "good", "regarding", "motor", "tics", ",", "vocal", "tics", ",", "and", "behavioral", "symptoms", "such", "as", "disturbed", "impulse", "control", "which", "still", "persisted", "after", "9", "months", ".", "These", "findings", "and", "the", "successful", "therapy", "underline", "reports", "of", "the", "literature", "and", "point", "to", "a", "pathogenetic", "mechanism", "of", "an", "immunologically", "triggered", "disturbance", "of", "the", "striatal", "dopaminergic", "system", ",", "at", "least", "in", "a", "subgroup", "of", "GTS", "." ]	[ "umlsterm" ]
time is an umlsterm, chorea is an umlsterm, tics is an umlsterm, syndrome is an umlsterm, Tics is an umlsterm, symptoms is an umlsterm, chorea is an umlsterm, symptoms is an umlsterm, children is an umlsterm, symptoms is an umlsterm, signs is an umlsterm, treatment is an umlsterm, diagnostic is an umlsterm, criteria is an umlsterm, susceptibility is an umlsterm, antibody is an umlsterm, antigens is an umlsterm, immunoglobulins is an umlsterm, therapy is an umlsterm, motor tics is an umlsterm, vocal tics is an umlsterm, behavioral symptoms is an umlsterm, control is an umlsterm, findings is an umlsterm, therapy is an umlsterm, literature is an umlsterm	DerNervenarzt.70680914.eng.abstr_task1	Sentence: It has known for a long time that Sydenham's chorea and tics , as seen in Gilles de la Tourette's syndrome ( GTS ) , are phenomenologically very similar . Tics may occur as symptoms of acute Sydenham's chorea or persist over years as residual symptoms . Investigations of children suffering from GTS , including obsessive-compusilve symptoms , have provided signs of a poststreptococcal autoimmune process but also shown that treatment based on immunological interventions has been effective . We treated a 14-year-old boy showing all diagnostic criteria of GTS , familial susceptibility , and an increase in the antibody titer of streptococcal antigens with 7S immunoglobulins i.v. over 5 days . Response to this therapy was good regarding motor tics , vocal tics , and behavioral symptoms such as disturbed impulse control which still persisted after 9 months . These findings and the successful therapy underline reports of the literature and point to a pathogenetic mechanism of an immunologically triggered disturbance of the striatal dopaminergic system , at least in a subgroup of GTS . Instructions: please typing these entity words according to sentence: time, chorea, tics, syndrome, Tics, symptoms, chorea, symptoms, children, symptoms, signs, treatment, diagnostic, criteria, susceptibility, antibody, antigens, immunoglobulins, therapy, motor tics, vocal tics, behavioral symptoms, control, findings, therapy, literature Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	It has known for a long time that Sydenham's chorea and tics , as seen in Gilles de la Tourette's syndrome ( GTS ) , are phenomenologically very similar . Tics may occur as symptoms of acute Sydenham's chorea or persist over years as residual symptoms . Investigations of children suffering from GTS , including obsessive-compusilve symptoms , have provided signs of a poststreptococcal autoimmune process but also shown that treatment based on immunological interventions has been effective . We treated a 14-year-old boy showing all diagnostic criteria of GTS , familial susceptibility , and an increase in the antibody titer of streptococcal antigens with 7S immunoglobulins i.v. over 5 days . Response to this therapy was good regarding motor tics , vocal tics , and behavioral symptoms such as disturbed impulse control which still persisted after 9 months . These findings and the successful therapy underline reports of the literature and point to a pathogenetic mechanism of an immunologically triggered disturbance of the striatal dopaminergic system , at least in a subgroup of GTS .	[ "It", "has", "known", "for", "a", "long", "time", "that", "Sydenham", "'s", "chorea", "and", "tics", ",", "as", "seen", "in", "Gilles", "de", "la", "Tourette", "'s", "syndrome", "(", "GTS", ")", ",", "are", "phenomenologically", "very", "similar", ".", "Tics", "may", "occur", "as", "symptoms", "of", "acute", "Sydenham", "'s", "chorea", "or", "persist", "over", "years", "as", "residual", "symptoms", ".", "Investigations", "of", "children", "suffering", "from", "GTS", ",", "including", "obsessive", "-", "compusilve", "symptoms", ",", "have", "provided", "signs", "of", "a", "poststreptococcal", "autoimmune", "process", "but", "also", "shown", "that", "treatment", "based", "on", "immunological", "interventions", "has", "been", "effective", ".", "We", "treated", "a", "14-year", "-", "old", "boy", "showing", "all", "diagnostic", "criteria", "of", "GTS", ",", "familial", "susceptibility", ",", "and", "an", "increase", "in", "the", "antibody", "titer", "of", "streptococcal", "antigens", "with", "7S", "immunoglobulins", "i.v", ".", "over", "5", "days", ".", "Response", "to", "this", "therapy", "was", "good", "regarding", "motor", "tics", ",", "vocal", "tics", ",", "and", "behavioral", "symptoms", "such", "as", "disturbed", "impulse", "control", "which", "still", "persisted", "after", "9", "months", ".", "These", "findings", "and", "the", "successful", "therapy", "underline", "reports", "of", "the", "literature", "and", "point", "to", "a", "pathogenetic", "mechanism", "of", "an", "immunologically", "triggered", "disturbance", "of", "the", "striatal", "dopaminergic", "system", ",", "at", "least", "in", "a", "subgroup", "of", "GTS", "." ]	[ "umlsterm" ]
time, chorea, tics, syndrome, Tics, symptoms, chorea, symptoms, children, symptoms, signs, treatment, diagnostic, criteria, susceptibility, antibody, antigens, immunoglobulins, therapy, motor tics, vocal tics, behavioral symptoms, control, findings, therapy, literature	DerNervenarzt.70680914.eng.abstr_task2	Sentence: It has known for a long time that Sydenham's chorea and tics , as seen in Gilles de la Tourette's syndrome ( GTS ) , are phenomenologically very similar . Tics may occur as symptoms of acute Sydenham's chorea or persist over years as residual symptoms . Investigations of children suffering from GTS , including obsessive-compusilve symptoms , have provided signs of a poststreptococcal autoimmune process but also shown that treatment based on immunological interventions has been effective . We treated a 14-year-old boy showing all diagnostic criteria of GTS , familial susceptibility , and an increase in the antibody titer of streptococcal antigens with 7S immunoglobulins i.v. over 5 days . Response to this therapy was good regarding motor tics , vocal tics , and behavioral symptoms such as disturbed impulse control which still persisted after 9 months . These findings and the successful therapy underline reports of the literature and point to a pathogenetic mechanism of an immunologically triggered disturbance of the striatal dopaminergic system , at least in a subgroup of GTS . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	It has known for a long time that Sydenham's chorea and tics , as seen in Gilles de la Tourette's syndrome ( GTS ) , are phenomenologically very similar . Tics may occur as symptoms of acute Sydenham's chorea or persist over years as residual symptoms . Investigations of children suffering from GTS , including obsessive-compusilve symptoms , have provided signs of a poststreptococcal autoimmune process but also shown that treatment based on immunological interventions has been effective . We treated a 14-year-old boy showing all diagnostic criteria of GTS , familial susceptibility , and an increase in the antibody titer of streptococcal antigens with 7S immunoglobulins i.v. over 5 days . Response to this therapy was good regarding motor tics , vocal tics , and behavioral symptoms such as disturbed impulse control which still persisted after 9 months . These findings and the successful therapy underline reports of the literature and point to a pathogenetic mechanism of an immunologically triggered disturbance of the striatal dopaminergic system , at least in a subgroup of GTS .	[ "It", "has", "known", "for", "a", "long", "time", "that", "Sydenham", "'s", "chorea", "and", "tics", ",", "as", "seen", "in", "Gilles", "de", "la", "Tourette", "'s", "syndrome", "(", "GTS", ")", ",", "are", "phenomenologically", "very", "similar", ".", "Tics", "may", "occur", "as", "symptoms", "of", "acute", "Sydenham", "'s", "chorea", "or", "persist", "over", "years", "as", "residual", "symptoms", ".", "Investigations", "of", "children", "suffering", "from", "GTS", ",", "including", "obsessive", "-", "compusilve", "symptoms", ",", "have", "provided", "signs", "of", "a", "poststreptococcal", "autoimmune", "process", "but", "also", "shown", "that", "treatment", "based", "on", "immunological", "interventions", "has", "been", "effective", ".", "We", "treated", "a", "14-year", "-", "old", "boy", "showing", "all", "diagnostic", "criteria", "of", "GTS", ",", "familial", "susceptibility", ",", "and", "an", "increase", "in", "the", "antibody", "titer", "of", "streptococcal", "antigens", "with", "7S", "immunoglobulins", "i.v", ".", "over", "5", "days", ".", "Response", "to", "this", "therapy", "was", "good", "regarding", "motor", "tics", ",", "vocal", "tics", ",", "and", "behavioral", "symptoms", "such", "as", "disturbed", "impulse", "control", "which", "still", "persisted", "after", "9", "months", ".", "These", "findings", "and", "the", "successful", "therapy", "underline", "reports", "of", "the", "literature", "and", "point", "to", "a", "pathogenetic", "mechanism", "of", "an", "immunologically", "triggered", "disturbance", "of", "the", "striatal", "dopaminergic", "system", ",", "at", "least", "in", "a", "subgroup", "of", "GTS", "." ]	[ "umlsterm" ]
PLA2G6 is a Protein, PLA2G6 is a Protein, calcium - independent phospholipase A2 is a Protein, iPLA(2)beta is a Protein, iPLA(2)beta is a Protein, PLA2G6 is a Protein, iPLA(2)beta is a Protein, ubiquitin is a Protein, ubiquitin is a Protein, iPLA(2)beta is a Protein, iPLA(2)beta is a Protein	296_task0	Sentence: Disrupted membrane homeostasis and accumulation of ubiquitinated proteins in a mouse model of infantile neuroaxonal dystrophy caused by PLA2G6 mutations. Mutations in the PLA2G6 gene, which encodes group VIA calcium-independent phospholipase A2 (iPLA(2)beta), were recently identified in patients with infantile neuroaxonal dystrophy (INAD) and neurodegeneration with brain iron accumulation. A pathological hallmark of these childhood neurodegenerative diseases is the presence of distinctive spheroids in distal axons that contain accumulated membranes. We used iPLA(2)beta-KO mice generated by homologous recombination to investigate neurodegenerative consequences of PLA2G6 mutations. iPLA(2)beta-KO mice developed age-dependent neurological impairment that was evident in rotarod, balance, and climbing tests by 13 months of age. The primary abnormality underlying this neurological impairment was the formation of spheroids containing tubulovesicular membranes remarkably similar to human INAD. Spheroids were strongly labeled with anti-ubiquitin antibodies. Accumulation of ubiquitinated protein in spheroids was evident in some brain regions as early as 4 months of age, and the onset of motor impairment correlated with a dramatic increase in ubiquitin-positive spheroids throughout the neuropil in nearly all brain regions. Furthermore accumulating ubiquitinated proteins were observed primarily in insoluble fractions of brain tissue, implicating protein aggregation in this pathogenic process. These results indicate that loss of iPLA(2)beta causes age-dependent impairment of axonal membrane homeostasis and protein degradation pathways, leading to age-dependent neurological impairment. iPLA(2)beta-KO mice will be useful for further studies of pathogenesis and experimental interventions in INAD and neurodegeneration with brain iron accumulation. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Disrupted membrane homeostasis and accumulation of ubiquitinated proteins in a mouse model of infantile neuroaxonal dystrophy caused by PLA2G6 mutations. Mutations in the PLA2G6 gene, which encodes group VIA calcium-independent phospholipase A2 (iPLA(2)beta), were recently identified in patients with infantile neuroaxonal dystrophy (INAD) and neurodegeneration with brain iron accumulation. A pathological hallmark of these childhood neurodegenerative diseases is the presence of distinctive spheroids in distal axons that contain accumulated membranes. We used iPLA(2)beta-KO mice generated by homologous recombination to investigate neurodegenerative consequences of PLA2G6 mutations. iPLA(2)beta-KO mice developed age-dependent neurological impairment that was evident in rotarod, balance, and climbing tests by 13 months of age. The primary abnormality underlying this neurological impairment was the formation of spheroids containing tubulovesicular membranes remarkably similar to human INAD. Spheroids were strongly labeled with anti-ubiquitin antibodies. Accumulation of ubiquitinated protein in spheroids was evident in some brain regions as early as 4 months of age, and the onset of motor impairment correlated with a dramatic increase in ubiquitin-positive spheroids throughout the neuropil in nearly all brain regions. Furthermore accumulating ubiquitinated proteins were observed primarily in insoluble fractions of brain tissue, implicating protein aggregation in this pathogenic process. These results indicate that loss of iPLA(2)beta causes age-dependent impairment of axonal membrane homeostasis and protein degradation pathways, leading to age-dependent neurological impairment. iPLA(2)beta-KO mice will be useful for further studies of pathogenesis and experimental interventions in INAD and neurodegeneration with brain iron accumulation.	[ "Disrupted", "membrane", "homeostasis", "and", "accumulation", "of", "ubiquitinated", "proteins", "in", "a", "mouse", "model", "of", "infantile", "neuroaxonal", "dystrophy", "caused", "by", "PLA2G6", "mutations", ".", "\n", "Mutations", "in", "the", "PLA2G6", "gene", ",", "which", "encodes", "group", "VIA", "calcium", "-", "independent", "phospholipase", "A2", "(", "iPLA(2)beta", ")", ",", "were", "recently", "identified", "in", "patients", "with", "infantile", "neuroaxonal", "dystrophy", "(", "INAD", ")", "and", "neurodegeneration", "with", "brain", "iron", "accumulation", ".", "A", "pathological", "hallmark", "of", "these", "childhood", "neurodegenerative", "diseases", "is", "the", "presence", "of", "distinctive", "spheroids", "in", "distal", "axons", "that", "contain", "accumulated", "membranes", ".", "We", "used", "iPLA(2)beta", "-", "KO", "mice", "generated", "by", "homologous", "recombination", "to", "investigate", "neurodegenerative", "consequences", "of", "PLA2G6", "mutations", ".", "iPLA(2)beta", "-", "KO", "mice", "developed", "age", "-", "dependent", "neurological", "impairment", "that", "was", "evident", "in", "rotarod", ",", "balance", ",", "and", "climbing", "tests", "by", "13", "months", "of", "age", ".", "The", "primary", "abnormality", "underlying", "this", "neurological", "impairment", "was", "the", "formation", "of", "spheroids", "containing", "tubulovesicular", "membranes", "remarkably", "similar", "to", "human", "INAD", ".", "Spheroids", "were", "strongly", "labeled", "with", "anti", "-", "ubiquitin", "antibodies", ".", "Accumulation", "of", "ubiquitinated", "protein", "in", "spheroids", "was", "evident", "in", "some", "brain", "regions", "as", "early", "as", "4", "months", "of", "age", ",", "and", "the", "onset", "of", "motor", "impairment", "correlated", "with", "a", "dramatic", "increase", "in", "ubiquitin", "-", "positive", "spheroids", "throughout", "the", "neuropil", "in", "nearly", "all", "brain", "regions", ".", "Furthermore", "accumulating", "ubiquitinated", "proteins", "were", "observed", "primarily", "in", "insoluble", "fractions", "of", "brain", "tissue", ",", "implicating", "protein", "aggregation", "in", "this", "pathogenic", "process", ".", "These", "results", "indicate", "that", "loss", "of", "iPLA(2)beta", "causes", "age", "-", "dependent", "impairment", "of", "axonal", "membrane", "homeostasis", "and", "protein", "degradation", "pathways", ",", "leading", "to", "age", "-", "dependent", "neurological", "impairment", ".", "iPLA(2)beta", "-", "KO", "mice", "will", "be", "useful", "for", "further", "studies", "of", "pathogenesis", "and", "experimental", "interventions", "in", "INAD", "and", "neurodegeneration", "with", "brain", "iron", "accumulation", ".", "\n" ]	[ "Protein" ]
PLA2G6 is a Protein, PLA2G6 is a Protein, calcium - independent phospholipase A2 is a Protein, iPLA(2)beta is a Protein, iPLA(2)beta is a Protein, PLA2G6 is a Protein, iPLA(2)beta is a Protein, ubiquitin is a Protein, ubiquitin is a Protein, iPLA(2)beta is a Protein, iPLA(2)beta is a Protein	296_task1	Sentence: Disrupted membrane homeostasis and accumulation of ubiquitinated proteins in a mouse model of infantile neuroaxonal dystrophy caused by PLA2G6 mutations. Mutations in the PLA2G6 gene, which encodes group VIA calcium-independent phospholipase A2 (iPLA(2)beta), were recently identified in patients with infantile neuroaxonal dystrophy (INAD) and neurodegeneration with brain iron accumulation. A pathological hallmark of these childhood neurodegenerative diseases is the presence of distinctive spheroids in distal axons that contain accumulated membranes. We used iPLA(2)beta-KO mice generated by homologous recombination to investigate neurodegenerative consequences of PLA2G6 mutations. iPLA(2)beta-KO mice developed age-dependent neurological impairment that was evident in rotarod, balance, and climbing tests by 13 months of age. The primary abnormality underlying this neurological impairment was the formation of spheroids containing tubulovesicular membranes remarkably similar to human INAD. Spheroids were strongly labeled with anti-ubiquitin antibodies. Accumulation of ubiquitinated protein in spheroids was evident in some brain regions as early as 4 months of age, and the onset of motor impairment correlated with a dramatic increase in ubiquitin-positive spheroids throughout the neuropil in nearly all brain regions. Furthermore accumulating ubiquitinated proteins were observed primarily in insoluble fractions of brain tissue, implicating protein aggregation in this pathogenic process. These results indicate that loss of iPLA(2)beta causes age-dependent impairment of axonal membrane homeostasis and protein degradation pathways, leading to age-dependent neurological impairment. iPLA(2)beta-KO mice will be useful for further studies of pathogenesis and experimental interventions in INAD and neurodegeneration with brain iron accumulation. Instructions: please typing these entity words according to sentence: PLA2G6, PLA2G6, calcium - independent phospholipase A2, iPLA(2)beta, iPLA(2)beta, PLA2G6, iPLA(2)beta, ubiquitin, ubiquitin, iPLA(2)beta, iPLA(2)beta Options: Protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Disrupted membrane homeostasis and accumulation of ubiquitinated proteins in a mouse model of infantile neuroaxonal dystrophy caused by PLA2G6 mutations. Mutations in the PLA2G6 gene, which encodes group VIA calcium-independent phospholipase A2 (iPLA(2)beta), were recently identified in patients with infantile neuroaxonal dystrophy (INAD) and neurodegeneration with brain iron accumulation. A pathological hallmark of these childhood neurodegenerative diseases is the presence of distinctive spheroids in distal axons that contain accumulated membranes. We used iPLA(2)beta-KO mice generated by homologous recombination to investigate neurodegenerative consequences of PLA2G6 mutations. iPLA(2)beta-KO mice developed age-dependent neurological impairment that was evident in rotarod, balance, and climbing tests by 13 months of age. The primary abnormality underlying this neurological impairment was the formation of spheroids containing tubulovesicular membranes remarkably similar to human INAD. Spheroids were strongly labeled with anti-ubiquitin antibodies. Accumulation of ubiquitinated protein in spheroids was evident in some brain regions as early as 4 months of age, and the onset of motor impairment correlated with a dramatic increase in ubiquitin-positive spheroids throughout the neuropil in nearly all brain regions. Furthermore accumulating ubiquitinated proteins were observed primarily in insoluble fractions of brain tissue, implicating protein aggregation in this pathogenic process. These results indicate that loss of iPLA(2)beta causes age-dependent impairment of axonal membrane homeostasis and protein degradation pathways, leading to age-dependent neurological impairment. iPLA(2)beta-KO mice will be useful for further studies of pathogenesis and experimental interventions in INAD and neurodegeneration with brain iron accumulation.	[ "Disrupted", "membrane", "homeostasis", "and", "accumulation", "of", "ubiquitinated", "proteins", "in", "a", "mouse", "model", "of", "infantile", "neuroaxonal", "dystrophy", "caused", "by", "PLA2G6", "mutations", ".", "\n", "Mutations", "in", "the", "PLA2G6", "gene", ",", "which", "encodes", "group", "VIA", "calcium", "-", "independent", "phospholipase", "A2", "(", "iPLA(2)beta", ")", ",", "were", "recently", "identified", "in", "patients", "with", "infantile", "neuroaxonal", "dystrophy", "(", "INAD", ")", "and", "neurodegeneration", "with", "brain", "iron", "accumulation", ".", "A", "pathological", "hallmark", "of", "these", "childhood", "neurodegenerative", "diseases", "is", "the", "presence", "of", "distinctive", "spheroids", "in", "distal", "axons", "that", "contain", "accumulated", "membranes", ".", "We", "used", "iPLA(2)beta", "-", "KO", "mice", "generated", "by", "homologous", "recombination", "to", "investigate", "neurodegenerative", "consequences", "of", "PLA2G6", "mutations", ".", "iPLA(2)beta", "-", "KO", "mice", "developed", "age", "-", "dependent", "neurological", "impairment", "that", "was", "evident", "in", "rotarod", ",", "balance", ",", "and", "climbing", "tests", "by", "13", "months", "of", "age", ".", "The", "primary", "abnormality", "underlying", "this", "neurological", "impairment", "was", "the", "formation", "of", "spheroids", "containing", "tubulovesicular", "membranes", "remarkably", "similar", "to", "human", "INAD", ".", "Spheroids", "were", "strongly", "labeled", "with", "anti", "-", "ubiquitin", "antibodies", ".", "Accumulation", "of", "ubiquitinated", "protein", "in", "spheroids", "was", "evident", "in", "some", "brain", "regions", "as", "early", "as", "4", "months", "of", "age", ",", "and", "the", "onset", "of", "motor", "impairment", "correlated", "with", "a", "dramatic", "increase", "in", "ubiquitin", "-", "positive", "spheroids", "throughout", "the", "neuropil", "in", "nearly", "all", "brain", "regions", ".", "Furthermore", "accumulating", "ubiquitinated", "proteins", "were", "observed", "primarily", "in", "insoluble", "fractions", "of", "brain", "tissue", ",", "implicating", "protein", "aggregation", "in", "this", "pathogenic", "process", ".", "These", "results", "indicate", "that", "loss", "of", "iPLA(2)beta", "causes", "age", "-", "dependent", "impairment", "of", "axonal", "membrane", "homeostasis", "and", "protein", "degradation", "pathways", ",", "leading", "to", "age", "-", "dependent", "neurological", "impairment", ".", "iPLA(2)beta", "-", "KO", "mice", "will", "be", "useful", "for", "further", "studies", "of", "pathogenesis", "and", "experimental", "interventions", "in", "INAD", "and", "neurodegeneration", "with", "brain", "iron", "accumulation", ".", "\n" ]	[ "Protein" ]
PLA2G6, PLA2G6, calcium - independent phospholipase A2, iPLA(2)beta, iPLA(2)beta, PLA2G6, iPLA(2)beta, ubiquitin, ubiquitin, iPLA(2)beta, iPLA(2)beta	296_task2	Sentence: Disrupted membrane homeostasis and accumulation of ubiquitinated proteins in a mouse model of infantile neuroaxonal dystrophy caused by PLA2G6 mutations. Mutations in the PLA2G6 gene, which encodes group VIA calcium-independent phospholipase A2 (iPLA(2)beta), were recently identified in patients with infantile neuroaxonal dystrophy (INAD) and neurodegeneration with brain iron accumulation. A pathological hallmark of these childhood neurodegenerative diseases is the presence of distinctive spheroids in distal axons that contain accumulated membranes. We used iPLA(2)beta-KO mice generated by homologous recombination to investigate neurodegenerative consequences of PLA2G6 mutations. iPLA(2)beta-KO mice developed age-dependent neurological impairment that was evident in rotarod, balance, and climbing tests by 13 months of age. The primary abnormality underlying this neurological impairment was the formation of spheroids containing tubulovesicular membranes remarkably similar to human INAD. Spheroids were strongly labeled with anti-ubiquitin antibodies. Accumulation of ubiquitinated protein in spheroids was evident in some brain regions as early as 4 months of age, and the onset of motor impairment correlated with a dramatic increase in ubiquitin-positive spheroids throughout the neuropil in nearly all brain regions. Furthermore accumulating ubiquitinated proteins were observed primarily in insoluble fractions of brain tissue, implicating protein aggregation in this pathogenic process. These results indicate that loss of iPLA(2)beta causes age-dependent impairment of axonal membrane homeostasis and protein degradation pathways, leading to age-dependent neurological impairment. iPLA(2)beta-KO mice will be useful for further studies of pathogenesis and experimental interventions in INAD and neurodegeneration with brain iron accumulation. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Disrupted membrane homeostasis and accumulation of ubiquitinated proteins in a mouse model of infantile neuroaxonal dystrophy caused by PLA2G6 mutations. Mutations in the PLA2G6 gene, which encodes group VIA calcium-independent phospholipase A2 (iPLA(2)beta), were recently identified in patients with infantile neuroaxonal dystrophy (INAD) and neurodegeneration with brain iron accumulation. A pathological hallmark of these childhood neurodegenerative diseases is the presence of distinctive spheroids in distal axons that contain accumulated membranes. We used iPLA(2)beta-KO mice generated by homologous recombination to investigate neurodegenerative consequences of PLA2G6 mutations. iPLA(2)beta-KO mice developed age-dependent neurological impairment that was evident in rotarod, balance, and climbing tests by 13 months of age. The primary abnormality underlying this neurological impairment was the formation of spheroids containing tubulovesicular membranes remarkably similar to human INAD. Spheroids were strongly labeled with anti-ubiquitin antibodies. Accumulation of ubiquitinated protein in spheroids was evident in some brain regions as early as 4 months of age, and the onset of motor impairment correlated with a dramatic increase in ubiquitin-positive spheroids throughout the neuropil in nearly all brain regions. Furthermore accumulating ubiquitinated proteins were observed primarily in insoluble fractions of brain tissue, implicating protein aggregation in this pathogenic process. These results indicate that loss of iPLA(2)beta causes age-dependent impairment of axonal membrane homeostasis and protein degradation pathways, leading to age-dependent neurological impairment. iPLA(2)beta-KO mice will be useful for further studies of pathogenesis and experimental interventions in INAD and neurodegeneration with brain iron accumulation.	[ "Disrupted", "membrane", "homeostasis", "and", "accumulation", "of", "ubiquitinated", "proteins", "in", "a", "mouse", "model", "of", "infantile", "neuroaxonal", "dystrophy", "caused", "by", "PLA2G6", "mutations", ".", "\n", "Mutations", "in", "the", "PLA2G6", "gene", ",", "which", "encodes", "group", "VIA", "calcium", "-", "independent", "phospholipase", "A2", "(", "iPLA(2)beta", ")", ",", "were", "recently", "identified", "in", "patients", "with", "infantile", "neuroaxonal", "dystrophy", "(", "INAD", ")", "and", "neurodegeneration", "with", "brain", "iron", "accumulation", ".", "A", "pathological", "hallmark", "of", "these", "childhood", "neurodegenerative", "diseases", "is", "the", "presence", "of", "distinctive", "spheroids", "in", "distal", "axons", "that", "contain", "accumulated", "membranes", ".", "We", "used", "iPLA(2)beta", "-", "KO", "mice", "generated", "by", "homologous", "recombination", "to", "investigate", "neurodegenerative", "consequences", "of", "PLA2G6", "mutations", ".", "iPLA(2)beta", "-", "KO", "mice", "developed", "age", "-", "dependent", "neurological", "impairment", "that", "was", "evident", "in", "rotarod", ",", "balance", ",", "and", "climbing", "tests", "by", "13", "months", "of", "age", ".", "The", "primary", "abnormality", "underlying", "this", "neurological", "impairment", "was", "the", "formation", "of", "spheroids", "containing", "tubulovesicular", "membranes", "remarkably", "similar", "to", "human", "INAD", ".", "Spheroids", "were", "strongly", "labeled", "with", "anti", "-", "ubiquitin", "antibodies", ".", "Accumulation", "of", "ubiquitinated", "protein", "in", "spheroids", "was", "evident", "in", "some", "brain", "regions", "as", "early", "as", "4", "months", "of", "age", ",", "and", "the", "onset", "of", "motor", "impairment", "correlated", "with", "a", "dramatic", "increase", "in", "ubiquitin", "-", "positive", "spheroids", "throughout", "the", "neuropil", "in", "nearly", "all", "brain", "regions", ".", "Furthermore", "accumulating", "ubiquitinated", "proteins", "were", "observed", "primarily", "in", "insoluble", "fractions", "of", "brain", "tissue", ",", "implicating", "protein", "aggregation", "in", "this", "pathogenic", "process", ".", "These", "results", "indicate", "that", "loss", "of", "iPLA(2)beta", "causes", "age", "-", "dependent", "impairment", "of", "axonal", "membrane", "homeostasis", "and", "protein", "degradation", "pathways", ",", "leading", "to", "age", "-", "dependent", "neurological", "impairment", ".", "iPLA(2)beta", "-", "KO", "mice", "will", "be", "useful", "for", "further", "studies", "of", "pathogenesis", "and", "experimental", "interventions", "in", "INAD", "and", "neurodegeneration", "with", "brain", "iron", "accumulation", ".", "\n" ]	[ "Protein" ]
Anxiety sensitivity is a Participant_Condition, later anxiety symptoms and syndromes is a Participant_Condition, anxiety sensitivity is a Participant_Condition, anxiety symptoms and panic is a Participant_Condition, anxiety psychopathology is a Intervention_Psychological, controlling for potential confounding factors is a Intervention_Educational, anxiety symptoms . is a Participant_Condition	35985_task0	Sentence: Anxiety sensitivity as an incremental predictor of later anxiety symptoms and syndromes . Although anxiety sensitivity ( AS ) has been shown to predict anxiety symptoms and panic , this literature is limited in regard to evaluating AS as an incremental predictor of anxiety psychopathology relative to other established risk factors including sex and negative affect . The present report prospectively evaluated whether AS was predictive of later changes in anxiety symptoms after controlling for potential confounding factors . Consistent with hypothesis , AS was found to be a significant , incremental predictor of anxiety symptoms over time , even after controlling for sex and negative affectivity . These data provide novel evidence for the unique association between AS of the development of anxiety symptoms . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Psychological, Intervention_Educational, Participant_Condition	[ "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Psychological", "I-Intervention_Psychological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition" ]	Anxiety sensitivity as an incremental predictor of later anxiety symptoms and syndromes . Although anxiety sensitivity ( AS ) has been shown to predict anxiety symptoms and panic , this literature is limited in regard to evaluating AS as an incremental predictor of anxiety psychopathology relative to other established risk factors including sex and negative affect . The present report prospectively evaluated whether AS was predictive of later changes in anxiety symptoms after controlling for potential confounding factors . Consistent with hypothesis , AS was found to be a significant , incremental predictor of anxiety symptoms over time , even after controlling for sex and negative affectivity . These data provide novel evidence for the unique association between AS of the development of anxiety symptoms .	[ "Anxiety", "sensitivity", "as", "an", "incremental", "predictor", "of", "later", "anxiety", "symptoms", "and", "syndromes", ".", "Although", "anxiety", "sensitivity", "(", "AS", ")", "has", "been", "shown", "to", "predict", "anxiety", "symptoms", "and", "panic", ",", "this", "literature", "is", "limited", "in", "regard", "to", "evaluating", "AS", "as", "an", "incremental", "predictor", "of", "anxiety", "psychopathology", "relative", "to", "other", "established", "risk", "factors", "including", "sex", "and", "negative", "affect", ".", "The", "present", "report", "prospectively", "evaluated", "whether", "AS", "was", "predictive", "of", "later", "changes", "in", "anxiety", "symptoms", "after", "controlling", "for", "potential", "confounding", "factors", ".", "Consistent", "with", "hypothesis", ",", "AS", "was", "found", "to", "be", "a", "significant", ",", "incremental", "predictor", "of", "anxiety", "symptoms", "over", "time", ",", "even", "after", "controlling", "for", "sex", "and", "negative", "affectivity", ".", "These", "data", "provide", "novel", "evidence", "for", "the", "unique", "association", "between", "AS", "of", "the", "development", "of", "anxiety", "symptoms", "." ]	[ "Intervention_Educational", "Participant_Condition", "Intervention_Psychological", "Outcome_Mental" ]
Anxiety sensitivity is a Participant_Condition, later anxiety symptoms and syndromes is a Participant_Condition, anxiety sensitivity is a Participant_Condition, anxiety symptoms and panic is a Participant_Condition, anxiety psychopathology is a Intervention_Psychological, controlling for potential confounding factors is a Intervention_Educational, anxiety symptoms . is a Participant_Condition	35985_task1	Sentence: Anxiety sensitivity as an incremental predictor of later anxiety symptoms and syndromes . Although anxiety sensitivity ( AS ) has been shown to predict anxiety symptoms and panic , this literature is limited in regard to evaluating AS as an incremental predictor of anxiety psychopathology relative to other established risk factors including sex and negative affect . The present report prospectively evaluated whether AS was predictive of later changes in anxiety symptoms after controlling for potential confounding factors . Consistent with hypothesis , AS was found to be a significant , incremental predictor of anxiety symptoms over time , even after controlling for sex and negative affectivity . These data provide novel evidence for the unique association between AS of the development of anxiety symptoms . Instructions: please typing these entity words according to sentence: Anxiety sensitivity, later anxiety symptoms and syndromes, anxiety sensitivity, anxiety symptoms and panic, anxiety psychopathology, controlling for potential confounding factors, anxiety symptoms . Options: Intervention_Psychological, Intervention_Educational, Participant_Condition	[ "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Psychological", "I-Intervention_Psychological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition" ]	Anxiety sensitivity as an incremental predictor of later anxiety symptoms and syndromes . Although anxiety sensitivity ( AS ) has been shown to predict anxiety symptoms and panic , this literature is limited in regard to evaluating AS as an incremental predictor of anxiety psychopathology relative to other established risk factors including sex and negative affect . The present report prospectively evaluated whether AS was predictive of later changes in anxiety symptoms after controlling for potential confounding factors . Consistent with hypothesis , AS was found to be a significant , incremental predictor of anxiety symptoms over time , even after controlling for sex and negative affectivity . These data provide novel evidence for the unique association between AS of the development of anxiety symptoms .	[ "Anxiety", "sensitivity", "as", "an", "incremental", "predictor", "of", "later", "anxiety", "symptoms", "and", "syndromes", ".", "Although", "anxiety", "sensitivity", "(", "AS", ")", "has", "been", "shown", "to", "predict", "anxiety", "symptoms", "and", "panic", ",", "this", "literature", "is", "limited", "in", "regard", "to", "evaluating", "AS", "as", "an", "incremental", "predictor", "of", "anxiety", "psychopathology", "relative", "to", "other", "established", "risk", "factors", "including", "sex", "and", "negative", "affect", ".", "The", "present", "report", "prospectively", "evaluated", "whether", "AS", "was", "predictive", "of", "later", "changes", "in", "anxiety", "symptoms", "after", "controlling", "for", "potential", "confounding", "factors", ".", "Consistent", "with", "hypothesis", ",", "AS", "was", "found", "to", "be", "a", "significant", ",", "incremental", "predictor", "of", "anxiety", "symptoms", "over", "time", ",", "even", "after", "controlling", "for", "sex", "and", "negative", "affectivity", ".", "These", "data", "provide", "novel", "evidence", "for", "the", "unique", "association", "between", "AS", "of", "the", "development", "of", "anxiety", "symptoms", "." ]	[ "Intervention_Educational", "Participant_Condition", "Intervention_Psychological", "Outcome_Mental" ]
Anxiety sensitivity, later anxiety symptoms and syndromes, anxiety sensitivity, anxiety symptoms and panic, anxiety psychopathology, controlling for potential confounding factors, anxiety symptoms .	35985_task2	Sentence: Anxiety sensitivity as an incremental predictor of later anxiety symptoms and syndromes . Although anxiety sensitivity ( AS ) has been shown to predict anxiety symptoms and panic , this literature is limited in regard to evaluating AS as an incremental predictor of anxiety psychopathology relative to other established risk factors including sex and negative affect . The present report prospectively evaluated whether AS was predictive of later changes in anxiety symptoms after controlling for potential confounding factors . Consistent with hypothesis , AS was found to be a significant , incremental predictor of anxiety symptoms over time , even after controlling for sex and negative affectivity . These data provide novel evidence for the unique association between AS of the development of anxiety symptoms . Instructions: please extract entity words from the input sentence	[ "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Psychological", "I-Intervention_Psychological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition" ]	Anxiety sensitivity as an incremental predictor of later anxiety symptoms and syndromes . Although anxiety sensitivity ( AS ) has been shown to predict anxiety symptoms and panic , this literature is limited in regard to evaluating AS as an incremental predictor of anxiety psychopathology relative to other established risk factors including sex and negative affect . The present report prospectively evaluated whether AS was predictive of later changes in anxiety symptoms after controlling for potential confounding factors . Consistent with hypothesis , AS was found to be a significant , incremental predictor of anxiety symptoms over time , even after controlling for sex and negative affectivity . These data provide novel evidence for the unique association between AS of the development of anxiety symptoms .	[ "Anxiety", "sensitivity", "as", "an", "incremental", "predictor", "of", "later", "anxiety", "symptoms", "and", "syndromes", ".", "Although", "anxiety", "sensitivity", "(", "AS", ")", "has", "been", "shown", "to", "predict", "anxiety", "symptoms", "and", "panic", ",", "this", "literature", "is", "limited", "in", "regard", "to", "evaluating", "AS", "as", "an", "incremental", "predictor", "of", "anxiety", "psychopathology", "relative", "to", "other", "established", "risk", "factors", "including", "sex", "and", "negative", "affect", ".", "The", "present", "report", "prospectively", "evaluated", "whether", "AS", "was", "predictive", "of", "later", "changes", "in", "anxiety", "symptoms", "after", "controlling", "for", "potential", "confounding", "factors", ".", "Consistent", "with", "hypothesis", ",", "AS", "was", "found", "to", "be", "a", "significant", ",", "incremental", "predictor", "of", "anxiety", "symptoms", "over", "time", ",", "even", "after", "controlling", "for", "sex", "and", "negative", "affectivity", ".", "These", "data", "provide", "novel", "evidence", "for", "the", "unique", "association", "between", "AS", "of", "the", "development", "of", "anxiety", "symptoms", "." ]	[ "Intervention_Educational", "Participant_Condition", "Intervention_Psychological", "Outcome_Mental" ]
pain - free treadmill training is a Intervention_Physical, fibrinogen is a Outcome_Physical, claudication is a Participant_Condition, plasma fibrinogen , haematocrit , lipid profile , and walking ability is a Outcome_Physical, Sixty - eight is a Participant_Sample-size, peripheral obstructive arterial disease is a Participant_Condition, intermittent claudication is a Participant_Condition, control group is a Intervention_Control, no change in physical activity is a Intervention_Physical, pain - free walking time ( PFWT ) is a Outcome_Physical, maximal walking time ( MWT ) is a Outcome_Physical, blood analyses [ for haematocrit , fibrinogen , triglycerides , and cholesterol : total , high - density lipoprotein ( HDL ) and low - density lipoprotein ( LDL ) ] is a Outcome_Physical, Total and LDL cholesterol levels is a Outcome_Physical, HDL cholesterol is a Outcome_Physical, Haematocrit is a Outcome_Physical	49879_task0	Sentence: The effect of pain-free treadmill training on fibrinogen , haematocrit , and lipid profile in patients with claudication . OBJECTIVE To assess the effect of pain-free treadmill training on changes of plasma fibrinogen , haematocrit , lipid profile , and walking ability in patients with claudication . DESIGN Randomized control trial . METHODS Sixty-eight patients with peripheral obstructive arterial disease and intermittent claudication ( Fontaine stage II ) were randomly assigned into the treadmill training ( repetitive intervals to onset of claudication pain , three times a week ) or a control group ( no change in physical activity ) over 3 months . Both groups performed treadmill test to assess pain-free walking time ( PFWT ) and maximal walking time ( MWT ) and had blood analyses [ for haematocrit , fibrinogen , triglycerides , and cholesterol : total , high-density lipoprotein ( HDL ) and low-density lipoprotein ( LDL ) ] done at baseline and after 6 and 12 weeks of the study . RESULTS Total and LDL cholesterol levels in the training group decreased ( p < 0.05 ) by 14.8 % and 20,5 % , respectively . Significant ( p < 0.05 ) HDL cholesterol increased ( 14.6 % ) and triglycerides decreased ( 19 % ) in the training group but changes of all these lipids were insignificant in the control group over the 3 months . Haematocrit and fibrinogen changes were insignificant in both groups . PFWT was prolonged by 109 % and MWT increased by 54 % in the training group ( p < 0.01 ) , but not in the control group . CONCLUSION The improvement in walking time over 3 months of pain-free treadmill training parallels with progressive normalization of lipid profiles in patients with claudication . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Physical, Intervention_Control, Participant_Condition, Outcome_Physical, Participant_Sample-size	[ "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The effect of pain-free treadmill training on fibrinogen , haematocrit , and lipid profile in patients with claudication . OBJECTIVE To assess the effect of pain-free treadmill training on changes of plasma fibrinogen , haematocrit , lipid profile , and walking ability in patients with claudication . DESIGN Randomized control trial . METHODS Sixty-eight patients with peripheral obstructive arterial disease and intermittent claudication ( Fontaine stage II ) were randomly assigned into the treadmill training ( repetitive intervals to onset of claudication pain , three times a week ) or a control group ( no change in physical activity ) over 3 months . Both groups performed treadmill test to assess pain-free walking time ( PFWT ) and maximal walking time ( MWT ) and had blood analyses [ for haematocrit , fibrinogen , triglycerides , and cholesterol : total , high-density lipoprotein ( HDL ) and low-density lipoprotein ( LDL ) ] done at baseline and after 6 and 12 weeks of the study . RESULTS Total and LDL cholesterol levels in the training group decreased ( p < 0.05 ) by 14.8 % and 20,5 % , respectively . Significant ( p < 0.05 ) HDL cholesterol increased ( 14.6 % ) and triglycerides decreased ( 19 % ) in the training group but changes of all these lipids were insignificant in the control group over the 3 months . Haematocrit and fibrinogen changes were insignificant in both groups . PFWT was prolonged by 109 % and MWT increased by 54 % in the training group ( p < 0.01 ) , but not in the control group . CONCLUSION The improvement in walking time over 3 months of pain-free treadmill training parallels with progressive normalization of lipid profiles in patients with claudication .	[ "The", "effect", "of", "pain", "-", "free", "treadmill", "training", "on", "fibrinogen", ",", "haematocrit", ",", "and", "lipid", "profile", "in", "patients", "with", "claudication", ".", "OBJECTIVE", "To", "assess", "the", "effect", "of", "pain", "-", "free", "treadmill", "training", "on", "changes", "of", "plasma", "fibrinogen", ",", "haematocrit", ",", "lipid", "profile", ",", "and", "walking", "ability", "in", "patients", "with", "claudication", ".", "DESIGN", "Randomized", "control", "trial", ".", "METHODS", "Sixty", "-", "eight", "patients", "with", "peripheral", "obstructive", "arterial", "disease", "and", "intermittent", "claudication", "(", "Fontaine", "stage", "II", ")", "were", "randomly", "assigned", "into", "the", "treadmill", "training", "(", "repetitive", "intervals", "to", "onset", "of", "claudication", "pain", ",", "three", "times", "a", "week", ")", "or", "a", "control", "group", "(", "no", "change", "in", "physical", "activity", ")", "over", "3", "months", ".", "Both", "groups", "performed", "treadmill", "test", "to", "assess", "pain", "-", "free", "walking", "time", "(", "PFWT", ")", "and", "maximal", "walking", "time", "(", "MWT", ")", "and", "had", "blood", "analyses", "[", "for", "haematocrit", ",", "fibrinogen", ",", "triglycerides", ",", "and", "cholesterol", ":", "total", ",", "high", "-", "density", "lipoprotein", "(", "HDL", ")", "and", "low", "-", "density", "lipoprotein", "(", "LDL", ")", "]", "done", "at", "baseline", "and", "after", "6", "and", "12", "weeks", "of", "the", "study", ".", "RESULTS", "Total", "and", "LDL", "cholesterol", "levels", "in", "the", "training", "group", "decreased", "(", "p", "<", "0.05", ")", "by", "14.8", "%", "and", "20,5", "%", ",", "respectively", ".", "Significant", "(", "p", "<", "0.05", ")", "HDL", "cholesterol", "increased", "(", "14.6", "%", ")", "and", "triglycerides", "decreased", "(", "19", "%", ")", "in", "the", "training", "group", "but", "changes", "of", "all", "these", "lipids", "were", "insignificant", "in", "the", "control", "group", "over", "the", "3", "months", ".", "Haematocrit", "and", "fibrinogen", "changes", "were", "insignificant", "in", "both", "groups", ".", "PFWT", "was", "prolonged", "by", "109", "%", "and", "MWT", "increased", "by", "54", "%", "in", "the", "training", "group", "(", "p", "<", "0.01", ")", ",", "but", "not", "in", "the", "control", "group", ".", "CONCLUSION", "The", "improvement", "in", "walking", "time", "over", "3", "months", "of", "pain", "-", "free", "treadmill", "training", "parallels", "with", "progressive", "normalization", "of", "lipid", "profiles", "in", "patients", "with", "claudication", "." ]	[ "Outcome_Physical", "Participant_Condition", "Intervention_Physical", "Intervention_Control", "Participant_Sample-size" ]
pain - free treadmill training is a Intervention_Physical, fibrinogen is a Outcome_Physical, claudication is a Participant_Condition, plasma fibrinogen , haematocrit , lipid profile , and walking ability is a Outcome_Physical, Sixty - eight is a Participant_Sample-size, peripheral obstructive arterial disease is a Participant_Condition, intermittent claudication is a Participant_Condition, control group is a Intervention_Control, no change in physical activity is a Intervention_Physical, pain - free walking time ( PFWT ) is a Outcome_Physical, maximal walking time ( MWT ) is a Outcome_Physical, blood analyses [ for haematocrit , fibrinogen , triglycerides , and cholesterol : total , high - density lipoprotein ( HDL ) and low - density lipoprotein ( LDL ) ] is a Outcome_Physical, Total and LDL cholesterol levels is a Outcome_Physical, HDL cholesterol is a Outcome_Physical, Haematocrit is a Outcome_Physical	49879_task1	Sentence: The effect of pain-free treadmill training on fibrinogen , haematocrit , and lipid profile in patients with claudication . OBJECTIVE To assess the effect of pain-free treadmill training on changes of plasma fibrinogen , haematocrit , lipid profile , and walking ability in patients with claudication . DESIGN Randomized control trial . METHODS Sixty-eight patients with peripheral obstructive arterial disease and intermittent claudication ( Fontaine stage II ) were randomly assigned into the treadmill training ( repetitive intervals to onset of claudication pain , three times a week ) or a control group ( no change in physical activity ) over 3 months . Both groups performed treadmill test to assess pain-free walking time ( PFWT ) and maximal walking time ( MWT ) and had blood analyses [ for haematocrit , fibrinogen , triglycerides , and cholesterol : total , high-density lipoprotein ( HDL ) and low-density lipoprotein ( LDL ) ] done at baseline and after 6 and 12 weeks of the study . RESULTS Total and LDL cholesterol levels in the training group decreased ( p < 0.05 ) by 14.8 % and 20,5 % , respectively . Significant ( p < 0.05 ) HDL cholesterol increased ( 14.6 % ) and triglycerides decreased ( 19 % ) in the training group but changes of all these lipids were insignificant in the control group over the 3 months . Haematocrit and fibrinogen changes were insignificant in both groups . PFWT was prolonged by 109 % and MWT increased by 54 % in the training group ( p < 0.01 ) , but not in the control group . CONCLUSION The improvement in walking time over 3 months of pain-free treadmill training parallels with progressive normalization of lipid profiles in patients with claudication . Instructions: please typing these entity words according to sentence: pain - free treadmill training, fibrinogen, claudication, plasma fibrinogen , haematocrit , lipid profile , and walking ability, Sixty - eight, peripheral obstructive arterial disease, intermittent claudication, control group, no change in physical activity, pain - free walking time ( PFWT ), maximal walking time ( MWT ), blood analyses [ for haematocrit , fibrinogen , triglycerides , and cholesterol : total , high - density lipoprotein ( HDL ) and low - density lipoprotein ( LDL ) ], Total and LDL cholesterol levels, HDL cholesterol, Haematocrit Options: Intervention_Physical, Intervention_Control, Participant_Condition, Outcome_Physical, Participant_Sample-size	[ "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The effect of pain-free treadmill training on fibrinogen , haematocrit , and lipid profile in patients with claudication . OBJECTIVE To assess the effect of pain-free treadmill training on changes of plasma fibrinogen , haematocrit , lipid profile , and walking ability in patients with claudication . DESIGN Randomized control trial . METHODS Sixty-eight patients with peripheral obstructive arterial disease and intermittent claudication ( Fontaine stage II ) were randomly assigned into the treadmill training ( repetitive intervals to onset of claudication pain , three times a week ) or a control group ( no change in physical activity ) over 3 months . Both groups performed treadmill test to assess pain-free walking time ( PFWT ) and maximal walking time ( MWT ) and had blood analyses [ for haematocrit , fibrinogen , triglycerides , and cholesterol : total , high-density lipoprotein ( HDL ) and low-density lipoprotein ( LDL ) ] done at baseline and after 6 and 12 weeks of the study . RESULTS Total and LDL cholesterol levels in the training group decreased ( p < 0.05 ) by 14.8 % and 20,5 % , respectively . Significant ( p < 0.05 ) HDL cholesterol increased ( 14.6 % ) and triglycerides decreased ( 19 % ) in the training group but changes of all these lipids were insignificant in the control group over the 3 months . Haematocrit and fibrinogen changes were insignificant in both groups . PFWT was prolonged by 109 % and MWT increased by 54 % in the training group ( p < 0.01 ) , but not in the control group . CONCLUSION The improvement in walking time over 3 months of pain-free treadmill training parallels with progressive normalization of lipid profiles in patients with claudication .	[ "The", "effect", "of", "pain", "-", "free", "treadmill", "training", "on", "fibrinogen", ",", "haematocrit", ",", "and", "lipid", "profile", "in", "patients", "with", "claudication", ".", "OBJECTIVE", "To", "assess", "the", "effect", "of", "pain", "-", "free", "treadmill", "training", "on", "changes", "of", "plasma", "fibrinogen", ",", "haematocrit", ",", "lipid", "profile", ",", "and", "walking", "ability", "in", "patients", "with", "claudication", ".", "DESIGN", "Randomized", "control", "trial", ".", "METHODS", "Sixty", "-", "eight", "patients", "with", "peripheral", "obstructive", "arterial", "disease", "and", "intermittent", "claudication", "(", "Fontaine", "stage", "II", ")", "were", "randomly", "assigned", "into", "the", "treadmill", "training", "(", "repetitive", "intervals", "to", "onset", "of", "claudication", "pain", ",", "three", "times", "a", "week", ")", "or", "a", "control", "group", "(", "no", "change", "in", "physical", "activity", ")", "over", "3", "months", ".", "Both", "groups", "performed", "treadmill", "test", "to", "assess", "pain", "-", "free", "walking", "time", "(", "PFWT", ")", "and", "maximal", "walking", "time", "(", "MWT", ")", "and", "had", "blood", "analyses", "[", "for", "haematocrit", ",", "fibrinogen", ",", "triglycerides", ",", "and", "cholesterol", ":", "total", ",", "high", "-", "density", "lipoprotein", "(", "HDL", ")", "and", "low", "-", "density", "lipoprotein", "(", "LDL", ")", "]", "done", "at", "baseline", "and", "after", "6", "and", "12", "weeks", "of", "the", "study", ".", "RESULTS", "Total", "and", "LDL", "cholesterol", "levels", "in", "the", "training", "group", "decreased", "(", "p", "<", "0.05", ")", "by", "14.8", "%", "and", "20,5", "%", ",", "respectively", ".", "Significant", "(", "p", "<", "0.05", ")", "HDL", "cholesterol", "increased", "(", "14.6", "%", ")", "and", "triglycerides", "decreased", "(", "19", "%", ")", "in", "the", "training", "group", "but", "changes", "of", "all", "these", "lipids", "were", "insignificant", "in", "the", "control", "group", "over", "the", "3", "months", ".", "Haematocrit", "and", "fibrinogen", "changes", "were", "insignificant", "in", "both", "groups", ".", "PFWT", "was", "prolonged", "by", "109", "%", "and", "MWT", "increased", "by", "54", "%", "in", "the", "training", "group", "(", "p", "<", "0.01", ")", ",", "but", "not", "in", "the", "control", "group", ".", "CONCLUSION", "The", "improvement", "in", "walking", "time", "over", "3", "months", "of", "pain", "-", "free", "treadmill", "training", "parallels", "with", "progressive", "normalization", "of", "lipid", "profiles", "in", "patients", "with", "claudication", "." ]	[ "Outcome_Physical", "Participant_Condition", "Intervention_Physical", "Intervention_Control", "Participant_Sample-size" ]
pain - free treadmill training, fibrinogen, claudication, plasma fibrinogen , haematocrit , lipid profile , and walking ability, Sixty - eight, peripheral obstructive arterial disease, intermittent claudication, control group, no change in physical activity, pain - free walking time ( PFWT ), maximal walking time ( MWT ), blood analyses [ for haematocrit , fibrinogen , triglycerides , and cholesterol : total , high - density lipoprotein ( HDL ) and low - density lipoprotein ( LDL ) ], Total and LDL cholesterol levels, HDL cholesterol, Haematocrit	49879_task2	Sentence: The effect of pain-free treadmill training on fibrinogen , haematocrit , and lipid profile in patients with claudication . OBJECTIVE To assess the effect of pain-free treadmill training on changes of plasma fibrinogen , haematocrit , lipid profile , and walking ability in patients with claudication . DESIGN Randomized control trial . METHODS Sixty-eight patients with peripheral obstructive arterial disease and intermittent claudication ( Fontaine stage II ) were randomly assigned into the treadmill training ( repetitive intervals to onset of claudication pain , three times a week ) or a control group ( no change in physical activity ) over 3 months . Both groups performed treadmill test to assess pain-free walking time ( PFWT ) and maximal walking time ( MWT ) and had blood analyses [ for haematocrit , fibrinogen , triglycerides , and cholesterol : total , high-density lipoprotein ( HDL ) and low-density lipoprotein ( LDL ) ] done at baseline and after 6 and 12 weeks of the study . RESULTS Total and LDL cholesterol levels in the training group decreased ( p < 0.05 ) by 14.8 % and 20,5 % , respectively . Significant ( p < 0.05 ) HDL cholesterol increased ( 14.6 % ) and triglycerides decreased ( 19 % ) in the training group but changes of all these lipids were insignificant in the control group over the 3 months . Haematocrit and fibrinogen changes were insignificant in both groups . PFWT was prolonged by 109 % and MWT increased by 54 % in the training group ( p < 0.01 ) , but not in the control group . CONCLUSION The improvement in walking time over 3 months of pain-free treadmill training parallels with progressive normalization of lipid profiles in patients with claudication . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The effect of pain-free treadmill training on fibrinogen , haematocrit , and lipid profile in patients with claudication . OBJECTIVE To assess the effect of pain-free treadmill training on changes of plasma fibrinogen , haematocrit , lipid profile , and walking ability in patients with claudication . DESIGN Randomized control trial . METHODS Sixty-eight patients with peripheral obstructive arterial disease and intermittent claudication ( Fontaine stage II ) were randomly assigned into the treadmill training ( repetitive intervals to onset of claudication pain , three times a week ) or a control group ( no change in physical activity ) over 3 months . Both groups performed treadmill test to assess pain-free walking time ( PFWT ) and maximal walking time ( MWT ) and had blood analyses [ for haematocrit , fibrinogen , triglycerides , and cholesterol : total , high-density lipoprotein ( HDL ) and low-density lipoprotein ( LDL ) ] done at baseline and after 6 and 12 weeks of the study . RESULTS Total and LDL cholesterol levels in the training group decreased ( p < 0.05 ) by 14.8 % and 20,5 % , respectively . Significant ( p < 0.05 ) HDL cholesterol increased ( 14.6 % ) and triglycerides decreased ( 19 % ) in the training group but changes of all these lipids were insignificant in the control group over the 3 months . Haematocrit and fibrinogen changes were insignificant in both groups . PFWT was prolonged by 109 % and MWT increased by 54 % in the training group ( p < 0.01 ) , but not in the control group . CONCLUSION The improvement in walking time over 3 months of pain-free treadmill training parallels with progressive normalization of lipid profiles in patients with claudication .	[ "The", "effect", "of", "pain", "-", "free", "treadmill", "training", "on", "fibrinogen", ",", "haematocrit", ",", "and", "lipid", "profile", "in", "patients", "with", "claudication", ".", "OBJECTIVE", "To", "assess", "the", "effect", "of", "pain", "-", "free", "treadmill", "training", "on", "changes", "of", "plasma", "fibrinogen", ",", "haematocrit", ",", "lipid", "profile", ",", "and", "walking", "ability", "in", "patients", "with", "claudication", ".", "DESIGN", "Randomized", "control", "trial", ".", "METHODS", "Sixty", "-", "eight", "patients", "with", "peripheral", "obstructive", "arterial", "disease", "and", "intermittent", "claudication", "(", "Fontaine", "stage", "II", ")", "were", "randomly", "assigned", "into", "the", "treadmill", "training", "(", "repetitive", "intervals", "to", "onset", "of", "claudication", "pain", ",", "three", "times", "a", "week", ")", "or", "a", "control", "group", "(", "no", "change", "in", "physical", "activity", ")", "over", "3", "months", ".", "Both", "groups", "performed", "treadmill", "test", "to", "assess", "pain", "-", "free", "walking", "time", "(", "PFWT", ")", "and", "maximal", "walking", "time", "(", "MWT", ")", "and", "had", "blood", "analyses", "[", "for", "haematocrit", ",", "fibrinogen", ",", "triglycerides", ",", "and", "cholesterol", ":", "total", ",", "high", "-", "density", "lipoprotein", "(", "HDL", ")", "and", "low", "-", "density", "lipoprotein", "(", "LDL", ")", "]", "done", "at", "baseline", "and", "after", "6", "and", "12", "weeks", "of", "the", "study", ".", "RESULTS", "Total", "and", "LDL", "cholesterol", "levels", "in", "the", "training", "group", "decreased", "(", "p", "<", "0.05", ")", "by", "14.8", "%", "and", "20,5", "%", ",", "respectively", ".", "Significant", "(", "p", "<", "0.05", ")", "HDL", "cholesterol", "increased", "(", "14.6", "%", ")", "and", "triglycerides", "decreased", "(", "19", "%", ")", "in", "the", "training", "group", "but", "changes", "of", "all", "these", "lipids", "were", "insignificant", "in", "the", "control", "group", "over", "the", "3", "months", ".", "Haematocrit", "and", "fibrinogen", "changes", "were", "insignificant", "in", "both", "groups", ".", "PFWT", "was", "prolonged", "by", "109", "%", "and", "MWT", "increased", "by", "54", "%", "in", "the", "training", "group", "(", "p", "<", "0.01", ")", ",", "but", "not", "in", "the", "control", "group", ".", "CONCLUSION", "The", "improvement", "in", "walking", "time", "over", "3", "months", "of", "pain", "-", "free", "treadmill", "training", "parallels", "with", "progressive", "normalization", "of", "lipid", "profiles", "in", "patients", "with", "claudication", "." ]	[ "Outcome_Physical", "Participant_Condition", "Intervention_Physical", "Intervention_Control", "Participant_Sample-size" ]
Opioide is an umlsterm, Patienten is an umlsterm, Aorta abdominalis is an umlsterm, Praemedikation is an umlsterm, Diazepam is an umlsterm, Patienten is an umlsterm, Patient is an umlsterm, Buprenorphin is an umlsterm, Fentanyl is an umlsterm, Morphin is an umlsterm, Nalbuphin is an umlsterm, Pentazocin is an umlsterm, Pethidin is an umlsterm, Tramadol is an umlsterm, Alfentanil is an umlsterm, Blutgasstatus is an umlsterm, Varianzanalyse is an umlsterm, Zeiteffekte is an umlsterm, Zeiteffekte is an umlsterm, Morphin is an umlsterm, Fentanyl is an umlsterm, Alfentanil is an umlsterm, Tramadol is an umlsterm, Nalbuphin is an umlsterm, Buprenorphin is an umlsterm, Atemdepression is an umlsterm, Gefaesswiderstands is an umlsterm, Pentazocin is an umlsterm, Pethidin is an umlsterm, Pethidin is an umlsterm, Atemdepression is an umlsterm, Katecholamine is an umlsterm, Histaminausschuettung is an umlsterm, Vasokonstriktion is an umlsterm	DerAnaesthesist.40430743.ger.abstr_task0	Sentence: Ziel der vorliegenden Untersuchung war die Erfassung haemodynamischer und respiratorischer Nebenwirkungen durch 8 verschiedene Opioide bei typischen kardiovaskulaeren Risikopatienten . Nach Aufklaerung und schriftlichem Einverstaendnis wurden 57 Patienten der Risikogruppen ASA III und IV , die sich einem Eingriff an der Aorta abdominalis unterziehen sollten , in randomisierter Form 8 Gruppen zugeteilt . Die Praemedikation mit 10 mg Diazepam i.m. erfolgte 60 min vor Eintreffen des Patienten im OP . Das gesamte invasive haemodynamische Monitoring ( art . RR HZV-PA-Katheter ) , wurde in Lokalanaesthesie angelegt . Danach erhielt jeder Patient der 8 Gruppen ein Opioid in einer aequipotenten , klinischen Dosierung ( Buprenorphin , Fentanyl , Morphin , Nalbuphin , Pentazocin , Pethidin , Tramadol , Alfentanil ) . 10 und 5 min vor sowie 5 , 10 , 15 und 20 min nach i.v. -Applikation des Opioids wurde ein kompletter haemodynamischer Status und Blutgasstatus erhoben . Die statistische Auswertung erfolgte mit der 1- bzw. 2faktoriellen Varianzanalyse ( p 0,05 ) . Signifikante Zeiteffekte , d . h . Abweichungen vom Ausgangswert zu den verschiedenen Messzeitpunkten , wurden fuer die Parameter HR und TPR , signifikante Gruppen- ( d . h . unterschiedliche Kurvenverlaeufe zwischen den verschiedenen Gruppen ) und Zeiteffekte fuer MPAP , PCWP , SVI , PaCO2 und PaO2 beobachtet . Keine wesentlichen Veraenderungen wurden nach Morphin , Fentanyl , Alfentanil , Tramadol und Nalbuphin festgestellt . Buprenorphin verursachte eine deutliche Atemdepression mit Anstieg des pulmonalen Gefaesswiderstands . Die Gabe von Pentazocin und Pethidin war von einem signifikanten Anstieg des MPAP und PVR begleitet . Pethidin erwies sich als am staerksten atemdepressiv . Als Ursachen fuer die beobachteten Nebenwirkungen muessen neben einer Atemdepression Faktoren wie eine Freisetzung endogener Katecholamine , eine Histaminausschuettung sowie eine hypoxisch bedingte pulmonale Vasokonstriktion diskutiert werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	Ziel der vorliegenden Untersuchung war die Erfassung haemodynamischer und respiratorischer Nebenwirkungen durch 8 verschiedene Opioide bei typischen kardiovaskulaeren Risikopatienten . Nach Aufklaerung und schriftlichem Einverstaendnis wurden 57 Patienten der Risikogruppen ASA III und IV , die sich einem Eingriff an der Aorta abdominalis unterziehen sollten , in randomisierter Form 8 Gruppen zugeteilt . Die Praemedikation mit 10 mg Diazepam i.m. erfolgte 60 min vor Eintreffen des Patienten im OP . Das gesamte invasive haemodynamische Monitoring ( art . RR HZV-PA-Katheter ) , wurde in Lokalanaesthesie angelegt . Danach erhielt jeder Patient der 8 Gruppen ein Opioid in einer aequipotenten , klinischen Dosierung ( Buprenorphin , Fentanyl , Morphin , Nalbuphin , Pentazocin , Pethidin , Tramadol , Alfentanil ) . 10 und 5 min vor sowie 5 , 10 , 15 und 20 min nach i.v. -Applikation des Opioids wurde ein kompletter haemodynamischer Status und Blutgasstatus erhoben . Die statistische Auswertung erfolgte mit der 1- bzw. 2faktoriellen Varianzanalyse ( p 0,05 ) . Signifikante Zeiteffekte , d . h . Abweichungen vom Ausgangswert zu den verschiedenen Messzeitpunkten , wurden fuer die Parameter HR und TPR , signifikante Gruppen- ( d . h . unterschiedliche Kurvenverlaeufe zwischen den verschiedenen Gruppen ) und Zeiteffekte fuer MPAP , PCWP , SVI , PaCO2 und PaO2 beobachtet . Keine wesentlichen Veraenderungen wurden nach Morphin , Fentanyl , Alfentanil , Tramadol und Nalbuphin festgestellt . Buprenorphin verursachte eine deutliche Atemdepression mit Anstieg des pulmonalen Gefaesswiderstands . Die Gabe von Pentazocin und Pethidin war von einem signifikanten Anstieg des MPAP und PVR begleitet . Pethidin erwies sich als am staerksten atemdepressiv . Als Ursachen fuer die beobachteten Nebenwirkungen muessen neben einer Atemdepression Faktoren wie eine Freisetzung endogener Katecholamine , eine Histaminausschuettung sowie eine hypoxisch bedingte pulmonale Vasokonstriktion diskutiert werden .	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Opioide is an umlsterm, Patienten is an umlsterm, Aorta abdominalis is an umlsterm, Praemedikation is an umlsterm, Diazepam is an umlsterm, Patienten is an umlsterm, Patient is an umlsterm, Buprenorphin is an umlsterm, Fentanyl is an umlsterm, Morphin is an umlsterm, Nalbuphin is an umlsterm, Pentazocin is an umlsterm, Pethidin is an umlsterm, Tramadol is an umlsterm, Alfentanil is an umlsterm, Blutgasstatus is an umlsterm, Varianzanalyse is an umlsterm, Zeiteffekte is an umlsterm, Zeiteffekte is an umlsterm, Morphin is an umlsterm, Fentanyl is an umlsterm, Alfentanil is an umlsterm, Tramadol is an umlsterm, Nalbuphin is an umlsterm, Buprenorphin is an umlsterm, Atemdepression is an umlsterm, Gefaesswiderstands is an umlsterm, Pentazocin is an umlsterm, Pethidin is an umlsterm, Pethidin is an umlsterm, Atemdepression is an umlsterm, Katecholamine is an umlsterm, Histaminausschuettung is an umlsterm, Vasokonstriktion is an umlsterm	DerAnaesthesist.40430743.ger.abstr_task1	Sentence: Ziel der vorliegenden Untersuchung war die Erfassung haemodynamischer und respiratorischer Nebenwirkungen durch 8 verschiedene Opioide bei typischen kardiovaskulaeren Risikopatienten . Nach Aufklaerung und schriftlichem Einverstaendnis wurden 57 Patienten der Risikogruppen ASA III und IV , die sich einem Eingriff an der Aorta abdominalis unterziehen sollten , in randomisierter Form 8 Gruppen zugeteilt . Die Praemedikation mit 10 mg Diazepam i.m. erfolgte 60 min vor Eintreffen des Patienten im OP . Das gesamte invasive haemodynamische Monitoring ( art . RR HZV-PA-Katheter ) , wurde in Lokalanaesthesie angelegt . Danach erhielt jeder Patient der 8 Gruppen ein Opioid in einer aequipotenten , klinischen Dosierung ( Buprenorphin , Fentanyl , Morphin , Nalbuphin , Pentazocin , Pethidin , Tramadol , Alfentanil ) . 10 und 5 min vor sowie 5 , 10 , 15 und 20 min nach i.v. -Applikation des Opioids wurde ein kompletter haemodynamischer Status und Blutgasstatus erhoben . Die statistische Auswertung erfolgte mit der 1- bzw. 2faktoriellen Varianzanalyse ( p 0,05 ) . Signifikante Zeiteffekte , d . h . Abweichungen vom Ausgangswert zu den verschiedenen Messzeitpunkten , wurden fuer die Parameter HR und TPR , signifikante Gruppen- ( d . h . unterschiedliche Kurvenverlaeufe zwischen den verschiedenen Gruppen ) und Zeiteffekte fuer MPAP , PCWP , SVI , PaCO2 und PaO2 beobachtet . Keine wesentlichen Veraenderungen wurden nach Morphin , Fentanyl , Alfentanil , Tramadol und Nalbuphin festgestellt . Buprenorphin verursachte eine deutliche Atemdepression mit Anstieg des pulmonalen Gefaesswiderstands . Die Gabe von Pentazocin und Pethidin war von einem signifikanten Anstieg des MPAP und PVR begleitet . Pethidin erwies sich als am staerksten atemdepressiv . Als Ursachen fuer die beobachteten Nebenwirkungen muessen neben einer Atemdepression Faktoren wie eine Freisetzung endogener Katecholamine , eine Histaminausschuettung sowie eine hypoxisch bedingte pulmonale Vasokonstriktion diskutiert werden . Instructions: please typing these entity words according to sentence: Opioide, Patienten, Aorta abdominalis, Praemedikation, Diazepam, Patienten, Patient, Buprenorphin, Fentanyl, Morphin, Nalbuphin, Pentazocin, Pethidin, Tramadol, Alfentanil, Blutgasstatus, Varianzanalyse, Zeiteffekte, Zeiteffekte, Morphin, Fentanyl, Alfentanil, Tramadol, Nalbuphin, Buprenorphin, Atemdepression, Gefaesswiderstands, Pentazocin, Pethidin, Pethidin, Atemdepression, Katecholamine, Histaminausschuettung, Vasokonstriktion Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	Ziel der vorliegenden Untersuchung war die Erfassung haemodynamischer und respiratorischer Nebenwirkungen durch 8 verschiedene Opioide bei typischen kardiovaskulaeren Risikopatienten . Nach Aufklaerung und schriftlichem Einverstaendnis wurden 57 Patienten der Risikogruppen ASA III und IV , die sich einem Eingriff an der Aorta abdominalis unterziehen sollten , in randomisierter Form 8 Gruppen zugeteilt . Die Praemedikation mit 10 mg Diazepam i.m. erfolgte 60 min vor Eintreffen des Patienten im OP . Das gesamte invasive haemodynamische Monitoring ( art . RR HZV-PA-Katheter ) , wurde in Lokalanaesthesie angelegt . Danach erhielt jeder Patient der 8 Gruppen ein Opioid in einer aequipotenten , klinischen Dosierung ( Buprenorphin , Fentanyl , Morphin , Nalbuphin , Pentazocin , Pethidin , Tramadol , Alfentanil ) . 10 und 5 min vor sowie 5 , 10 , 15 und 20 min nach i.v. -Applikation des Opioids wurde ein kompletter haemodynamischer Status und Blutgasstatus erhoben . Die statistische Auswertung erfolgte mit der 1- bzw. 2faktoriellen Varianzanalyse ( p 0,05 ) . Signifikante Zeiteffekte , d . h . Abweichungen vom Ausgangswert zu den verschiedenen Messzeitpunkten , wurden fuer die Parameter HR und TPR , signifikante Gruppen- ( d . h . unterschiedliche Kurvenverlaeufe zwischen den verschiedenen Gruppen ) und Zeiteffekte fuer MPAP , PCWP , SVI , PaCO2 und PaO2 beobachtet . Keine wesentlichen Veraenderungen wurden nach Morphin , Fentanyl , Alfentanil , Tramadol und Nalbuphin festgestellt . Buprenorphin verursachte eine deutliche Atemdepression mit Anstieg des pulmonalen Gefaesswiderstands . Die Gabe von Pentazocin und Pethidin war von einem signifikanten Anstieg des MPAP und PVR begleitet . Pethidin erwies sich als am staerksten atemdepressiv . Als Ursachen fuer die beobachteten Nebenwirkungen muessen neben einer Atemdepression Faktoren wie eine Freisetzung endogener Katecholamine , eine Histaminausschuettung sowie eine hypoxisch bedingte pulmonale Vasokonstriktion diskutiert werden .	[ "Ziel", "der", "vorliegenden", "Untersuchung", "war", "die", "Erfassung", "haemodynamischer", "und", "respiratorischer", "Nebenwirkungen", "durch", "8", "verschiedene", "Opioide", "bei", "typischen", "kardiovaskulaeren", "Risikopatienten", ".", "Nach", "Aufklaerung", "und", "schriftlichem", "Einverstaendnis", "wurden", "57", "Patienten", "der", "Risikogruppen", "ASA", "III", "und", "IV", ",", "die", "sich", "einem", "Eingriff", "an", "der", "Aorta", "abdominalis", "unterziehen", "sollten", ",", "in", "randomisierter", "Form", "8", "Gruppen", "zugeteilt", ".", "Die", "Praemedikation", "mit", "10", "mg", "Diazepam", "i.m", ".", "erfolgte", "60", "min", "vor", "Eintreffen", "des", "Patienten", "im", "OP", ".", "Das", "gesamte", "invasive", "haemodynamische", "Monitoring", "(", "art", ".", "RR", "HZV", "-", "PA", "-", "Katheter", ")", ",", "wurde", "in", "Lokalanaesthesie", "angelegt", ".", "Danach", "erhielt", "jeder", "Patient", "der", "8", "Gruppen", "ein", "Opioid", "in", "einer", "aequipotenten", ",", "klinischen", "Dosierung", "(", "Buprenorphin", ",", "Fentanyl", ",", "Morphin", ",", "Nalbuphin", ",", "Pentazocin", ",", "Pethidin", ",", "Tramadol", ",", "Alfentanil", ")", ".", "10", "und", "5", "min", "vor", "sowie", "5", ",", "10", ",", "15", "und", "20", "min", "nach", "i.v", ".", "-Applikation", "des", "Opioids", "wurde", "ein", "kompletter", "haemodynamischer", "Status", "und", "Blutgasstatus", "erhoben", ".", "Die", "statistische", "Auswertung", "erfolgte", "mit", "der", "1-", "bzw", ".", "2faktoriellen", "Varianzanalyse", "(", "p", "0,05", ")", ".", "Signifikante", "Zeiteffekte", ",", "d", ".", "h", ".", "Abweichungen", "vom", "Ausgangswert", "zu", "den", "verschiedenen", "Messzeitpunkten", ",", "wurden", "fuer", "die", "Parameter", "HR", "und", "TPR", ",", "signifikante", "Gruppen-", "(", "d", ".", "h", ".", "unterschiedliche", "Kurvenverlaeufe", "zwischen", "den", "verschiedenen", "Gruppen", ")", "und", "Zeiteffekte", "fuer", "MPAP", ",", "PCWP", ",", "SVI", ",", "PaCO2", "und", "PaO2", "beobachtet", ".", "Keine", "wesentlichen", "Veraenderungen", "wurden", "nach", "Morphin", ",", "Fentanyl", ",", "Alfentanil", ",", "Tramadol", "und", "Nalbuphin", "festgestellt", ".", "Buprenorphin", "verursachte", "eine", "deutliche", "Atemdepression", "mit", "Anstieg", "des", "pulmonalen", "Gefaesswiderstands", ".", "Die", "Gabe", "von", "Pentazocin", "und", "Pethidin", "war", "von", "einem", "signifikanten", "Anstieg", "des", "MPAP", "und", "PVR", "begleitet", ".", "Pethidin", "erwies", "sich", "als", "am", "staerksten", "atemdepressiv", ".", "Als", "Ursachen", "fuer", "die", "beobachteten", "Nebenwirkungen", "muessen", "neben", "einer", "Atemdepression", "Faktoren", "wie", "eine", "Freisetzung", "endogener", "Katecholamine", ",", "eine", "Histaminausschuettung", "sowie", "eine", "hypoxisch", "bedingte", "pulmonale", "Vasokonstriktion", "diskutiert", "werden", "." ]	[ "umlsterm" ]
Opioide, Patienten, Aorta abdominalis, Praemedikation, Diazepam, Patienten, Patient, Buprenorphin, Fentanyl, Morphin, Nalbuphin, Pentazocin, Pethidin, Tramadol, Alfentanil, Blutgasstatus, Varianzanalyse, Zeiteffekte, Zeiteffekte, Morphin, Fentanyl, Alfentanil, Tramadol, Nalbuphin, Buprenorphin, Atemdepression, Gefaesswiderstands, Pentazocin, Pethidin, Pethidin, Atemdepression, Katecholamine, Histaminausschuettung, Vasokonstriktion	DerAnaesthesist.40430743.ger.abstr_task2	Sentence: Ziel der vorliegenden Untersuchung war die Erfassung haemodynamischer und respiratorischer Nebenwirkungen durch 8 verschiedene Opioide bei typischen kardiovaskulaeren Risikopatienten . Nach Aufklaerung und schriftlichem Einverstaendnis wurden 57 Patienten der Risikogruppen ASA III und IV , die sich einem Eingriff an der Aorta abdominalis unterziehen sollten , in randomisierter Form 8 Gruppen zugeteilt . Die Praemedikation mit 10 mg Diazepam i.m. erfolgte 60 min vor Eintreffen des Patienten im OP . Das gesamte invasive haemodynamische Monitoring ( art . RR HZV-PA-Katheter ) , wurde in Lokalanaesthesie angelegt . Danach erhielt jeder Patient der 8 Gruppen ein Opioid in einer aequipotenten , klinischen Dosierung ( Buprenorphin , Fentanyl , Morphin , Nalbuphin , Pentazocin , Pethidin , Tramadol , Alfentanil ) . 10 und 5 min vor sowie 5 , 10 , 15 und 20 min nach i.v. -Applikation des Opioids wurde ein kompletter haemodynamischer Status und Blutgasstatus erhoben . Die statistische Auswertung erfolgte mit der 1- bzw. 2faktoriellen Varianzanalyse ( p 0,05 ) . Signifikante Zeiteffekte , d . h . Abweichungen vom Ausgangswert zu den verschiedenen Messzeitpunkten , wurden fuer die Parameter HR und TPR , signifikante Gruppen- ( d . h . unterschiedliche Kurvenverlaeufe zwischen den verschiedenen Gruppen ) und Zeiteffekte fuer MPAP , PCWP , SVI , PaCO2 und PaO2 beobachtet . Keine wesentlichen Veraenderungen wurden nach Morphin , Fentanyl , Alfentanil , Tramadol und Nalbuphin festgestellt . Buprenorphin verursachte eine deutliche Atemdepression mit Anstieg des pulmonalen Gefaesswiderstands . Die Gabe von Pentazocin und Pethidin war von einem signifikanten Anstieg des MPAP und PVR begleitet . Pethidin erwies sich als am staerksten atemdepressiv . Als Ursachen fuer die beobachteten Nebenwirkungen muessen neben einer Atemdepression Faktoren wie eine Freisetzung endogener Katecholamine , eine Histaminausschuettung sowie eine hypoxisch bedingte pulmonale Vasokonstriktion diskutiert werden . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	Ziel der vorliegenden Untersuchung war die Erfassung haemodynamischer und respiratorischer Nebenwirkungen durch 8 verschiedene Opioide bei typischen kardiovaskulaeren Risikopatienten . Nach Aufklaerung und schriftlichem Einverstaendnis wurden 57 Patienten der Risikogruppen ASA III und IV , die sich einem Eingriff an der Aorta abdominalis unterziehen sollten , in randomisierter Form 8 Gruppen zugeteilt . Die Praemedikation mit 10 mg Diazepam i.m. erfolgte 60 min vor Eintreffen des Patienten im OP . Das gesamte invasive haemodynamische Monitoring ( art . RR HZV-PA-Katheter ) , wurde in Lokalanaesthesie angelegt . Danach erhielt jeder Patient der 8 Gruppen ein Opioid in einer aequipotenten , klinischen Dosierung ( Buprenorphin , Fentanyl , Morphin , Nalbuphin , Pentazocin , Pethidin , Tramadol , Alfentanil ) . 10 und 5 min vor sowie 5 , 10 , 15 und 20 min nach i.v. -Applikation des Opioids wurde ein kompletter haemodynamischer Status und Blutgasstatus erhoben . Die statistische Auswertung erfolgte mit der 1- bzw. 2faktoriellen Varianzanalyse ( p 0,05 ) . Signifikante Zeiteffekte , d . h . Abweichungen vom Ausgangswert zu den verschiedenen Messzeitpunkten , wurden fuer die Parameter HR und TPR , signifikante Gruppen- ( d . h . unterschiedliche Kurvenverlaeufe zwischen den verschiedenen Gruppen ) und Zeiteffekte fuer MPAP , PCWP , SVI , PaCO2 und PaO2 beobachtet . Keine wesentlichen Veraenderungen wurden nach Morphin , Fentanyl , Alfentanil , Tramadol und Nalbuphin festgestellt . Buprenorphin verursachte eine deutliche Atemdepression mit Anstieg des pulmonalen Gefaesswiderstands . Die Gabe von Pentazocin und Pethidin war von einem signifikanten Anstieg des MPAP und PVR begleitet . Pethidin erwies sich als am staerksten atemdepressiv . Als Ursachen fuer die beobachteten Nebenwirkungen muessen neben einer Atemdepression Faktoren wie eine Freisetzung endogener Katecholamine , eine Histaminausschuettung sowie eine hypoxisch bedingte pulmonale Vasokonstriktion diskutiert werden .	[ "Ziel", "der", "vorliegenden", "Untersuchung", "war", "die", "Erfassung", "haemodynamischer", "und", "respiratorischer", "Nebenwirkungen", "durch", "8", "verschiedene", "Opioide", "bei", "typischen", "kardiovaskulaeren", "Risikopatienten", ".", "Nach", "Aufklaerung", "und", "schriftlichem", "Einverstaendnis", "wurden", "57", "Patienten", "der", "Risikogruppen", "ASA", "III", "und", "IV", ",", "die", "sich", "einem", "Eingriff", "an", "der", "Aorta", "abdominalis", "unterziehen", "sollten", ",", "in", "randomisierter", "Form", "8", "Gruppen", "zugeteilt", ".", "Die", "Praemedikation", "mit", "10", "mg", "Diazepam", "i.m", ".", "erfolgte", "60", "min", "vor", "Eintreffen", "des", "Patienten", "im", "OP", ".", "Das", "gesamte", "invasive", "haemodynamische", "Monitoring", "(", "art", ".", "RR", "HZV", "-", "PA", "-", "Katheter", ")", ",", "wurde", "in", "Lokalanaesthesie", "angelegt", ".", "Danach", "erhielt", "jeder", "Patient", "der", "8", "Gruppen", "ein", "Opioid", "in", "einer", "aequipotenten", ",", "klinischen", "Dosierung", "(", "Buprenorphin", ",", "Fentanyl", ",", "Morphin", ",", "Nalbuphin", ",", "Pentazocin", ",", "Pethidin", ",", "Tramadol", ",", "Alfentanil", ")", ".", "10", "und", "5", "min", "vor", "sowie", "5", ",", "10", ",", "15", "und", "20", "min", "nach", "i.v", ".", "-Applikation", "des", "Opioids", "wurde", "ein", "kompletter", "haemodynamischer", "Status", "und", "Blutgasstatus", "erhoben", ".", "Die", "statistische", "Auswertung", "erfolgte", "mit", "der", "1-", "bzw", ".", "2faktoriellen", "Varianzanalyse", "(", "p", "0,05", ")", ".", "Signifikante", "Zeiteffekte", ",", "d", ".", "h", ".", "Abweichungen", "vom", "Ausgangswert", "zu", "den", "verschiedenen", "Messzeitpunkten", ",", "wurden", "fuer", "die", "Parameter", "HR", "und", "TPR", ",", "signifikante", "Gruppen-", "(", "d", ".", "h", ".", "unterschiedliche", "Kurvenverlaeufe", "zwischen", "den", "verschiedenen", "Gruppen", ")", "und", "Zeiteffekte", "fuer", "MPAP", ",", "PCWP", ",", "SVI", ",", "PaCO2", "und", "PaO2", "beobachtet", ".", "Keine", "wesentlichen", "Veraenderungen", "wurden", "nach", "Morphin", ",", "Fentanyl", ",", "Alfentanil", ",", "Tramadol", "und", "Nalbuphin", "festgestellt", ".", "Buprenorphin", "verursachte", "eine", "deutliche", "Atemdepression", "mit", "Anstieg", "des", "pulmonalen", "Gefaesswiderstands", ".", "Die", "Gabe", "von", "Pentazocin", "und", "Pethidin", "war", "von", "einem", "signifikanten", "Anstieg", "des", "MPAP", "und", "PVR", "begleitet", ".", "Pethidin", "erwies", "sich", "als", "am", "staerksten", "atemdepressiv", ".", "Als", "Ursachen", "fuer", "die", "beobachteten", "Nebenwirkungen", "muessen", "neben", "einer", "Atemdepression", "Faktoren", "wie", "eine", "Freisetzung", "endogener", "Katecholamine", ",", "eine", "Histaminausschuettung", "sowie", "eine", "hypoxisch", "bedingte", "pulmonale", "Vasokonstriktion", "diskutiert", "werden", "." ]	[ "umlsterm" ]
Antipsychotika is an umlsterm, Lebensqualitaet is an umlsterm, Patienten is an umlsterm, Stigmatisierung is an umlsterm	DerNervenarzt.00710919.ger.abstr_task0	Sentence: Mit der Einfuehrung der sog . atypischen Antipsychotika verbesserte sich die Lebensqualitaet von Patienten mit einer schizophrenen Spektrumserkrankung erheblich . Die positiven Effekte zeigen sich sowohl in einer Reduzierung extrapyramidalmotorischer Nebenwirkungen und damit geringerer Stigmatisierung als auch in verbesserter kognitiver Leistungsfaehigkeit , erleichterter sozialer Integration , verkuerzter stationaerer Aufenthaltsdauer und geringeren Wiederaufnahmeraten . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Mit der Einfuehrung der sog . atypischen Antipsychotika verbesserte sich die Lebensqualitaet von Patienten mit einer schizophrenen Spektrumserkrankung erheblich . Die positiven Effekte zeigen sich sowohl in einer Reduzierung extrapyramidalmotorischer Nebenwirkungen und damit geringerer Stigmatisierung als auch in verbesserter kognitiver Leistungsfaehigkeit , erleichterter sozialer Integration , verkuerzter stationaerer Aufenthaltsdauer und geringeren Wiederaufnahmeraten .	[ "Mit", "der", "Einfuehrung", "der", "sog", ".", "atypischen", "Antipsychotika", "verbesserte", "sich", "die", "Lebensqualitaet", "von", "Patienten", "mit", "einer", "schizophrenen", "Spektrumserkrankung", "erheblich", ".", "Die", "positiven", "Effekte", "zeigen", "sich", "sowohl", "in", "einer", "Reduzierung", "extrapyramidalmotorischer", "Nebenwirkungen", "und", "damit", "geringerer", "Stigmatisierung", "als", "auch", "in", "verbesserter", "kognitiver", "Leistungsfaehigkeit", ",", "erleichterter", "sozialer", "Integration", ",", "verkuerzter", "stationaerer", "Aufenthaltsdauer", "und", "geringeren", "Wiederaufnahmeraten", "." ]	[ "umlsterm" ]
Antipsychotika is an umlsterm, Lebensqualitaet is an umlsterm, Patienten is an umlsterm, Stigmatisierung is an umlsterm	DerNervenarzt.00710919.ger.abstr_task1	Sentence: Mit der Einfuehrung der sog . atypischen Antipsychotika verbesserte sich die Lebensqualitaet von Patienten mit einer schizophrenen Spektrumserkrankung erheblich . Die positiven Effekte zeigen sich sowohl in einer Reduzierung extrapyramidalmotorischer Nebenwirkungen und damit geringerer Stigmatisierung als auch in verbesserter kognitiver Leistungsfaehigkeit , erleichterter sozialer Integration , verkuerzter stationaerer Aufenthaltsdauer und geringeren Wiederaufnahmeraten . Instructions: please typing these entity words according to sentence: Antipsychotika, Lebensqualitaet, Patienten, Stigmatisierung Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Mit der Einfuehrung der sog . atypischen Antipsychotika verbesserte sich die Lebensqualitaet von Patienten mit einer schizophrenen Spektrumserkrankung erheblich . Die positiven Effekte zeigen sich sowohl in einer Reduzierung extrapyramidalmotorischer Nebenwirkungen und damit geringerer Stigmatisierung als auch in verbesserter kognitiver Leistungsfaehigkeit , erleichterter sozialer Integration , verkuerzter stationaerer Aufenthaltsdauer und geringeren Wiederaufnahmeraten .	[ "Mit", "der", "Einfuehrung", "der", "sog", ".", "atypischen", "Antipsychotika", "verbesserte", "sich", "die", "Lebensqualitaet", "von", "Patienten", "mit", "einer", "schizophrenen", "Spektrumserkrankung", "erheblich", ".", "Die", "positiven", "Effekte", "zeigen", "sich", "sowohl", "in", "einer", "Reduzierung", "extrapyramidalmotorischer", "Nebenwirkungen", "und", "damit", "geringerer", "Stigmatisierung", "als", "auch", "in", "verbesserter", "kognitiver", "Leistungsfaehigkeit", ",", "erleichterter", "sozialer", "Integration", ",", "verkuerzter", "stationaerer", "Aufenthaltsdauer", "und", "geringeren", "Wiederaufnahmeraten", "." ]	[ "umlsterm" ]
Antipsychotika, Lebensqualitaet, Patienten, Stigmatisierung	DerNervenarzt.00710919.ger.abstr_task2	Sentence: Mit der Einfuehrung der sog . atypischen Antipsychotika verbesserte sich die Lebensqualitaet von Patienten mit einer schizophrenen Spektrumserkrankung erheblich . Die positiven Effekte zeigen sich sowohl in einer Reduzierung extrapyramidalmotorischer Nebenwirkungen und damit geringerer Stigmatisierung als auch in verbesserter kognitiver Leistungsfaehigkeit , erleichterter sozialer Integration , verkuerzter stationaerer Aufenthaltsdauer und geringeren Wiederaufnahmeraten . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Mit der Einfuehrung der sog . atypischen Antipsychotika verbesserte sich die Lebensqualitaet von Patienten mit einer schizophrenen Spektrumserkrankung erheblich . Die positiven Effekte zeigen sich sowohl in einer Reduzierung extrapyramidalmotorischer Nebenwirkungen und damit geringerer Stigmatisierung als auch in verbesserter kognitiver Leistungsfaehigkeit , erleichterter sozialer Integration , verkuerzter stationaerer Aufenthaltsdauer und geringeren Wiederaufnahmeraten .	[ "Mit", "der", "Einfuehrung", "der", "sog", ".", "atypischen", "Antipsychotika", "verbesserte", "sich", "die", "Lebensqualitaet", "von", "Patienten", "mit", "einer", "schizophrenen", "Spektrumserkrankung", "erheblich", ".", "Die", "positiven", "Effekte", "zeigen", "sich", "sowohl", "in", "einer", "Reduzierung", "extrapyramidalmotorischer", "Nebenwirkungen", "und", "damit", "geringerer", "Stigmatisierung", "als", "auch", "in", "verbesserter", "kognitiver", "Leistungsfaehigkeit", ",", "erleichterter", "sozialer", "Integration", ",", "verkuerzter", "stationaerer", "Aufenthaltsdauer", "und", "geringeren", "Wiederaufnahmeraten", "." ]	[ "umlsterm" ]
surgeries is an umlsterm, tissues is an umlsterm, forceps is an umlsterm, procedure is an umlsterm, forceps is an umlsterm, hemostasis is an umlsterm, method is an umlsterm, irrigation is an umlsterm, forceps is an umlsterm, sodium chloride solution is an umlsterm, coagulation is an umlsterm, irrigation is an umlsterm, forceps is an umlsterm, surgery is an umlsterm, irrigation is an umlsterm, sodium chloride solution is an umlsterm, imaging is an umlsterm, coagulation is an umlsterm, tissue is an umlsterm, faster is an umlsterm, coagulation is an umlsterm, tip is an umlsterm, forceps is an umlsterm, coagulation is an umlsterm, experimental - surgical is an umlsterm, tests is an umlsterm, forceps is an umlsterm, methods is an umlsterm, tissue is an umlsterm, coagulation is an umlsterm, irrigation is an umlsterm, electrode is an umlsterm, development is an umlsterm, time is an umlsterm, risk of is an umlsterm, complications is an umlsterm	MundKieferGesichtschirurgie.00040324.eng.abstr_task0	Sentence: Problem : During most surgeries , tissues are coagulated by a high-frequency current in order to stop the bleeding . Usually , bipolar forceps are used for this procedure . Until now it could not be avoided , however , that the biotissue would adhere to the forceps ends making hemostasis more difficult to achieve . Can this negative effect possibly be avoided ? Material and method : A newly developed bipolar irrigation forceps spilling out a 0.9% sodium chloride solution during the coagulation process has been designed to avoid this disadvantage . The irrigation forceps has been tested and evaluated experimentally in surgery as well as clinically . Results : The irrigation liquid selected is a 0.9% sodium chloride solution . Thermal imaging during biotissue coagulation has shown that the tissue heats up more and faster with flushed coagulation , and that the tip of the forceps heats up less than with unirrigated coagulation . In both experimental-surgical as well as in clinical tests it was possible to stop the biotissue sticking to the ends of the forceps . This effect was also confirmed histologically . Conclusion : Since other methods of avoiding the sticking effect during tissue coagulation by a high-frequency current have not been successful until now , the bipolar irrigation electrode is a promising new development . It helps the surgeon to work more efficiently and safely without having to adapt to big changes , and , at the same time , it reduces the risk of complications . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O" ]	Problem : During most surgeries , tissues are coagulated by a high-frequency current in order to stop the bleeding . Usually , bipolar forceps are used for this procedure . Until now it could not be avoided , however , that the biotissue would adhere to the forceps ends making hemostasis more difficult to achieve . Can this negative effect possibly be avoided ? Material and method : A newly developed bipolar irrigation forceps spilling out a 0.9% sodium chloride solution during the coagulation process has been designed to avoid this disadvantage . The irrigation forceps has been tested and evaluated experimentally in surgery as well as clinically . Results : The irrigation liquid selected is a 0.9% sodium chloride solution . Thermal imaging during biotissue coagulation has shown that the tissue heats up more and faster with flushed coagulation , and that the tip of the forceps heats up less than with unirrigated coagulation . In both experimental-surgical as well as in clinical tests it was possible to stop the biotissue sticking to the ends of the forceps . This effect was also confirmed histologically . Conclusion : Since other methods of avoiding the sticking effect during tissue coagulation by a high-frequency current have not been successful until now , the bipolar irrigation electrode is a promising new development . It helps the surgeon to work more efficiently and safely without having to adapt to big changes , and , at the same time , it reduces the risk of complications .	[ "Problem", ":", "During", "most", "surgeries", ",", "tissues", "are", "coagulated", "by", "a", "high", "-", "frequency", "current", "in", "order", "to", "stop", "the", "bleeding", ".", "Usually", ",", "bipolar", "forceps", "are", "used", "for", "this", "procedure", ".", "Until", "now", "it", "could", "not", "be", "avoided", ",", "however", ",", "that", "the", "biotissue", "would", "adhere", "to", "the", "forceps", "ends", "making", "hemostasis", "more", "difficult", "to", "achieve", ".", "Can", "this", "negative", "effect", "possibly", "be", "avoided", "?", "Material", "and", "method", ":", "A", "newly", "developed", "bipolar", "irrigation", "forceps", "spilling", "out", "a", "0.9", "%", "sodium", "chloride", "solution", "during", "the", "coagulation", "process", "has", "been", "designed", "to", "avoid", "this", "disadvantage", ".", "The", "irrigation", "forceps", "has", "been", "tested", "and", "evaluated", "experimentally", "in", "surgery", "as", "well", "as", "clinically", ".", "Results", ":", "The", "irrigation", "liquid", "selected", "is", "a", "0.9", "%", "sodium", "chloride", "solution", ".", "Thermal", "imaging", "during", "biotissue", "coagulation", "has", "shown", "that", "the", "tissue", "heats", "up", "more", "and", "faster", "with", "flushed", "coagulation", ",", "and", "that", "the", "tip", "of", "the", "forceps", "heats", "up", "less", "than", "with", "unirrigated", "coagulation", ".", "In", "both", "experimental", "-", "surgical", "as", "well", "as", "in", "clinical", "tests", "it", "was", "possible", "to", "stop", "the", "biotissue", "sticking", "to", "the", "ends", "of", "the", "forceps", ".", "This", "effect", "was", "also", "confirmed", "histologically", ".", "Conclusion", ":", "Since", "other", "methods", "of", "avoiding", "the", "sticking", "effect", "during", "tissue", "coagulation", "by", "a", "high", "-", "frequency", "current", "have", "not", "been", "successful", "until", "now", ",", "the", "bipolar", "irrigation", "electrode", "is", "a", "promising", "new", "development", ".", "It", "helps", "the", "surgeon", "to", "work", "more", "efficiently", "and", "safely", "without", "having", "to", "adapt", "to", "big", "changes", ",", "and", ",", "at", "the", "same", "time", ",", "it", "reduces", "the", "risk", "of", "complications", "." ]	[ "umlsterm" ]
surgeries is an umlsterm, tissues is an umlsterm, forceps is an umlsterm, procedure is an umlsterm, forceps is an umlsterm, hemostasis is an umlsterm, method is an umlsterm, irrigation is an umlsterm, forceps is an umlsterm, sodium chloride solution is an umlsterm, coagulation is an umlsterm, irrigation is an umlsterm, forceps is an umlsterm, surgery is an umlsterm, irrigation is an umlsterm, sodium chloride solution is an umlsterm, imaging is an umlsterm, coagulation is an umlsterm, tissue is an umlsterm, faster is an umlsterm, coagulation is an umlsterm, tip is an umlsterm, forceps is an umlsterm, coagulation is an umlsterm, experimental - surgical is an umlsterm, tests is an umlsterm, forceps is an umlsterm, methods is an umlsterm, tissue is an umlsterm, coagulation is an umlsterm, irrigation is an umlsterm, electrode is an umlsterm, development is an umlsterm, time is an umlsterm, risk of is an umlsterm, complications is an umlsterm	MundKieferGesichtschirurgie.00040324.eng.abstr_task1	Sentence: Problem : During most surgeries , tissues are coagulated by a high-frequency current in order to stop the bleeding . Usually , bipolar forceps are used for this procedure . Until now it could not be avoided , however , that the biotissue would adhere to the forceps ends making hemostasis more difficult to achieve . Can this negative effect possibly be avoided ? Material and method : A newly developed bipolar irrigation forceps spilling out a 0.9% sodium chloride solution during the coagulation process has been designed to avoid this disadvantage . The irrigation forceps has been tested and evaluated experimentally in surgery as well as clinically . Results : The irrigation liquid selected is a 0.9% sodium chloride solution . Thermal imaging during biotissue coagulation has shown that the tissue heats up more and faster with flushed coagulation , and that the tip of the forceps heats up less than with unirrigated coagulation . In both experimental-surgical as well as in clinical tests it was possible to stop the biotissue sticking to the ends of the forceps . This effect was also confirmed histologically . Conclusion : Since other methods of avoiding the sticking effect during tissue coagulation by a high-frequency current have not been successful until now , the bipolar irrigation electrode is a promising new development . It helps the surgeon to work more efficiently and safely without having to adapt to big changes , and , at the same time , it reduces the risk of complications . Instructions: please typing these entity words according to sentence: surgeries, tissues, forceps, procedure, forceps, hemostasis, method, irrigation, forceps, sodium chloride solution, coagulation, irrigation, forceps, surgery, irrigation, sodium chloride solution, imaging, coagulation, tissue, faster, coagulation, tip, forceps, coagulation, experimental - surgical, tests, forceps, methods, tissue, coagulation, irrigation, electrode, development, time, risk of, complications Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O" ]	Problem : During most surgeries , tissues are coagulated by a high-frequency current in order to stop the bleeding . Usually , bipolar forceps are used for this procedure . Until now it could not be avoided , however , that the biotissue would adhere to the forceps ends making hemostasis more difficult to achieve . Can this negative effect possibly be avoided ? Material and method : A newly developed bipolar irrigation forceps spilling out a 0.9% sodium chloride solution during the coagulation process has been designed to avoid this disadvantage . The irrigation forceps has been tested and evaluated experimentally in surgery as well as clinically . Results : The irrigation liquid selected is a 0.9% sodium chloride solution . Thermal imaging during biotissue coagulation has shown that the tissue heats up more and faster with flushed coagulation , and that the tip of the forceps heats up less than with unirrigated coagulation . In both experimental-surgical as well as in clinical tests it was possible to stop the biotissue sticking to the ends of the forceps . This effect was also confirmed histologically . Conclusion : Since other methods of avoiding the sticking effect during tissue coagulation by a high-frequency current have not been successful until now , the bipolar irrigation electrode is a promising new development . It helps the surgeon to work more efficiently and safely without having to adapt to big changes , and , at the same time , it reduces the risk of complications .	[ "Problem", ":", "During", "most", "surgeries", ",", "tissues", "are", "coagulated", "by", "a", "high", "-", "frequency", "current", "in", "order", "to", "stop", "the", "bleeding", ".", "Usually", ",", "bipolar", "forceps", "are", "used", "for", "this", "procedure", ".", "Until", "now", "it", "could", "not", "be", "avoided", ",", "however", ",", "that", "the", "biotissue", "would", "adhere", "to", "the", "forceps", "ends", "making", "hemostasis", "more", "difficult", "to", "achieve", ".", "Can", "this", "negative", "effect", "possibly", "be", "avoided", "?", "Material", "and", "method", ":", "A", "newly", "developed", "bipolar", "irrigation", "forceps", "spilling", "out", "a", "0.9", "%", "sodium", "chloride", "solution", "during", "the", "coagulation", "process", "has", "been", "designed", "to", "avoid", "this", "disadvantage", ".", "The", "irrigation", "forceps", "has", "been", "tested", "and", "evaluated", "experimentally", "in", "surgery", "as", "well", "as", "clinically", ".", "Results", ":", "The", "irrigation", "liquid", "selected", "is", "a", "0.9", "%", "sodium", "chloride", "solution", ".", "Thermal", "imaging", "during", "biotissue", "coagulation", "has", "shown", "that", "the", "tissue", "heats", "up", "more", "and", "faster", "with", "flushed", "coagulation", ",", "and", "that", "the", "tip", "of", "the", "forceps", "heats", "up", "less", "than", "with", "unirrigated", "coagulation", ".", "In", "both", "experimental", "-", "surgical", "as", "well", "as", "in", "clinical", "tests", "it", "was", "possible", "to", "stop", "the", "biotissue", "sticking", "to", "the", "ends", "of", "the", "forceps", ".", "This", "effect", "was", "also", "confirmed", "histologically", ".", "Conclusion", ":", "Since", "other", "methods", "of", "avoiding", "the", "sticking", "effect", "during", "tissue", "coagulation", "by", "a", "high", "-", "frequency", "current", "have", "not", "been", "successful", "until", "now", ",", "the", "bipolar", "irrigation", "electrode", "is", "a", "promising", "new", "development", ".", "It", "helps", "the", "surgeon", "to", "work", "more", "efficiently", "and", "safely", "without", "having", "to", "adapt", "to", "big", "changes", ",", "and", ",", "at", "the", "same", "time", ",", "it", "reduces", "the", "risk", "of", "complications", "." ]	[ "umlsterm" ]
surgeries, tissues, forceps, procedure, forceps, hemostasis, method, irrigation, forceps, sodium chloride solution, coagulation, irrigation, forceps, surgery, irrigation, sodium chloride solution, imaging, coagulation, tissue, faster, coagulation, tip, forceps, coagulation, experimental - surgical, tests, forceps, methods, tissue, coagulation, irrigation, electrode, development, time, risk of, complications	MundKieferGesichtschirurgie.00040324.eng.abstr_task2	Sentence: Problem : During most surgeries , tissues are coagulated by a high-frequency current in order to stop the bleeding . Usually , bipolar forceps are used for this procedure . Until now it could not be avoided , however , that the biotissue would adhere to the forceps ends making hemostasis more difficult to achieve . Can this negative effect possibly be avoided ? Material and method : A newly developed bipolar irrigation forceps spilling out a 0.9% sodium chloride solution during the coagulation process has been designed to avoid this disadvantage . The irrigation forceps has been tested and evaluated experimentally in surgery as well as clinically . Results : The irrigation liquid selected is a 0.9% sodium chloride solution . Thermal imaging during biotissue coagulation has shown that the tissue heats up more and faster with flushed coagulation , and that the tip of the forceps heats up less than with unirrigated coagulation . In both experimental-surgical as well as in clinical tests it was possible to stop the biotissue sticking to the ends of the forceps . This effect was also confirmed histologically . Conclusion : Since other methods of avoiding the sticking effect during tissue coagulation by a high-frequency current have not been successful until now , the bipolar irrigation electrode is a promising new development . It helps the surgeon to work more efficiently and safely without having to adapt to big changes , and , at the same time , it reduces the risk of complications . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O" ]	Problem : During most surgeries , tissues are coagulated by a high-frequency current in order to stop the bleeding . Usually , bipolar forceps are used for this procedure . Until now it could not be avoided , however , that the biotissue would adhere to the forceps ends making hemostasis more difficult to achieve . Can this negative effect possibly be avoided ? Material and method : A newly developed bipolar irrigation forceps spilling out a 0.9% sodium chloride solution during the coagulation process has been designed to avoid this disadvantage . The irrigation forceps has been tested and evaluated experimentally in surgery as well as clinically . Results : The irrigation liquid selected is a 0.9% sodium chloride solution . Thermal imaging during biotissue coagulation has shown that the tissue heats up more and faster with flushed coagulation , and that the tip of the forceps heats up less than with unirrigated coagulation . In both experimental-surgical as well as in clinical tests it was possible to stop the biotissue sticking to the ends of the forceps . This effect was also confirmed histologically . Conclusion : Since other methods of avoiding the sticking effect during tissue coagulation by a high-frequency current have not been successful until now , the bipolar irrigation electrode is a promising new development . It helps the surgeon to work more efficiently and safely without having to adapt to big changes , and , at the same time , it reduces the risk of complications .	[ "Problem", ":", "During", "most", "surgeries", ",", "tissues", "are", "coagulated", "by", "a", "high", "-", "frequency", "current", "in", "order", "to", "stop", "the", "bleeding", ".", "Usually", ",", "bipolar", "forceps", "are", "used", "for", "this", "procedure", ".", "Until", "now", "it", "could", "not", "be", "avoided", ",", "however", ",", "that", "the", "biotissue", "would", "adhere", "to", "the", "forceps", "ends", "making", "hemostasis", "more", "difficult", "to", "achieve", ".", "Can", "this", "negative", "effect", "possibly", "be", "avoided", "?", "Material", "and", "method", ":", "A", "newly", "developed", "bipolar", "irrigation", "forceps", "spilling", "out", "a", "0.9", "%", "sodium", "chloride", "solution", "during", "the", "coagulation", "process", "has", "been", "designed", "to", "avoid", "this", "disadvantage", ".", "The", "irrigation", "forceps", "has", "been", "tested", "and", "evaluated", "experimentally", "in", "surgery", "as", "well", "as", "clinically", ".", "Results", ":", "The", "irrigation", "liquid", "selected", "is", "a", "0.9", "%", "sodium", "chloride", "solution", ".", "Thermal", "imaging", "during", "biotissue", "coagulation", "has", "shown", "that", "the", "tissue", "heats", "up", "more", "and", "faster", "with", "flushed", "coagulation", ",", "and", "that", "the", "tip", "of", "the", "forceps", "heats", "up", "less", "than", "with", "unirrigated", "coagulation", ".", "In", "both", "experimental", "-", "surgical", "as", "well", "as", "in", "clinical", "tests", "it", "was", "possible", "to", "stop", "the", "biotissue", "sticking", "to", "the", "ends", "of", "the", "forceps", ".", "This", "effect", "was", "also", "confirmed", "histologically", ".", "Conclusion", ":", "Since", "other", "methods", "of", "avoiding", "the", "sticking", "effect", "during", "tissue", "coagulation", "by", "a", "high", "-", "frequency", "current", "have", "not", "been", "successful", "until", "now", ",", "the", "bipolar", "irrigation", "electrode", "is", "a", "promising", "new", "development", ".", "It", "helps", "the", "surgeon", "to", "work", "more", "efficiently", "and", "safely", "without", "having", "to", "adapt", "to", "big", "changes", ",", "and", ",", "at", "the", "same", "time", ",", "it", "reduces", "the", "risk", "of", "complications", "." ]	[ "umlsterm" ]
aortic valve is an umlsterm, tumor is an umlsterm, mesothelioma is an umlsterm, autopsy is an umlsterm, tumor is an umlsterm, right is an umlsterm, myocardial infarction is an umlsterm, heart is an umlsterm, tumor is an umlsterm, atrioventricular node is an umlsterm, knowledge is an umlsterm, tumors is an umlsterm	DerPathologe.00210250.eng.abstr_task0	Sentence: We describe a rare case of a papillary fibroelastoma of the aortic valve occurring simultaneously with a cystic tumor ( a so-called mesothelioma ) of the atrioventricular nodal region . At autopsy the tumor was found to prolapse into and occlude the right coronary ostium , leading to an acute , recurring myocardial infarction . Histological examination of the grossly unremarkable conduction system of the heart revealed a cystic tumor in the region of the atrioventricular node . To our knowledge , this is the first report of coexistence of these two rare cardiac tumors . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	We describe a rare case of a papillary fibroelastoma of the aortic valve occurring simultaneously with a cystic tumor ( a so-called mesothelioma ) of the atrioventricular nodal region . At autopsy the tumor was found to prolapse into and occlude the right coronary ostium , leading to an acute , recurring myocardial infarction . Histological examination of the grossly unremarkable conduction system of the heart revealed a cystic tumor in the region of the atrioventricular node . To our knowledge , this is the first report of coexistence of these two rare cardiac tumors .	[ "We", "describe", "a", "rare", "case", "of", "a", "papillary", "fibroelastoma", "of", "the", "aortic", "valve", "occurring", "simultaneously", "with", "a", "cystic", "tumor", "(", "a", "so", "-", "called", "mesothelioma", ")", "of", "the", "atrioventricular", "nodal", "region", ".", "At", "autopsy", "the", "tumor", "was", "found", "to", "prolapse", "into", "and", "occlude", "the", "right", "coronary", "ostium", ",", "leading", "to", "an", "acute", ",", "recurring", "myocardial", "infarction", ".", "Histological", "examination", "of", "the", "grossly", "unremarkable", "conduction", "system", "of", "the", "heart", "revealed", "a", "cystic", "tumor", "in", "the", "region", "of", "the", "atrioventricular", "node", ".", "To", "our", "knowledge", ",", "this", "is", "the", "first", "report", "of", "coexistence", "of", "these", "two", "rare", "cardiac", "tumors", "." ]	[ "umlsterm" ]
aortic valve is an umlsterm, tumor is an umlsterm, mesothelioma is an umlsterm, autopsy is an umlsterm, tumor is an umlsterm, right is an umlsterm, myocardial infarction is an umlsterm, heart is an umlsterm, tumor is an umlsterm, atrioventricular node is an umlsterm, knowledge is an umlsterm, tumors is an umlsterm	DerPathologe.00210250.eng.abstr_task1	Sentence: We describe a rare case of a papillary fibroelastoma of the aortic valve occurring simultaneously with a cystic tumor ( a so-called mesothelioma ) of the atrioventricular nodal region . At autopsy the tumor was found to prolapse into and occlude the right coronary ostium , leading to an acute , recurring myocardial infarction . Histological examination of the grossly unremarkable conduction system of the heart revealed a cystic tumor in the region of the atrioventricular node . To our knowledge , this is the first report of coexistence of these two rare cardiac tumors . Instructions: please typing these entity words according to sentence: aortic valve, tumor, mesothelioma, autopsy, tumor, right, myocardial infarction, heart, tumor, atrioventricular node, knowledge, tumors Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	We describe a rare case of a papillary fibroelastoma of the aortic valve occurring simultaneously with a cystic tumor ( a so-called mesothelioma ) of the atrioventricular nodal region . At autopsy the tumor was found to prolapse into and occlude the right coronary ostium , leading to an acute , recurring myocardial infarction . Histological examination of the grossly unremarkable conduction system of the heart revealed a cystic tumor in the region of the atrioventricular node . To our knowledge , this is the first report of coexistence of these two rare cardiac tumors .	[ "We", "describe", "a", "rare", "case", "of", "a", "papillary", "fibroelastoma", "of", "the", "aortic", "valve", "occurring", "simultaneously", "with", "a", "cystic", "tumor", "(", "a", "so", "-", "called", "mesothelioma", ")", "of", "the", "atrioventricular", "nodal", "region", ".", "At", "autopsy", "the", "tumor", "was", "found", "to", "prolapse", "into", "and", "occlude", "the", "right", "coronary", "ostium", ",", "leading", "to", "an", "acute", ",", "recurring", "myocardial", "infarction", ".", "Histological", "examination", "of", "the", "grossly", "unremarkable", "conduction", "system", "of", "the", "heart", "revealed", "a", "cystic", "tumor", "in", "the", "region", "of", "the", "atrioventricular", "node", ".", "To", "our", "knowledge", ",", "this", "is", "the", "first", "report", "of", "coexistence", "of", "these", "two", "rare", "cardiac", "tumors", "." ]	[ "umlsterm" ]
aortic valve, tumor, mesothelioma, autopsy, tumor, right, myocardial infarction, heart, tumor, atrioventricular node, knowledge, tumors	DerPathologe.00210250.eng.abstr_task2	Sentence: We describe a rare case of a papillary fibroelastoma of the aortic valve occurring simultaneously with a cystic tumor ( a so-called mesothelioma ) of the atrioventricular nodal region . At autopsy the tumor was found to prolapse into and occlude the right coronary ostium , leading to an acute , recurring myocardial infarction . Histological examination of the grossly unremarkable conduction system of the heart revealed a cystic tumor in the region of the atrioventricular node . To our knowledge , this is the first report of coexistence of these two rare cardiac tumors . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	We describe a rare case of a papillary fibroelastoma of the aortic valve occurring simultaneously with a cystic tumor ( a so-called mesothelioma ) of the atrioventricular nodal region . At autopsy the tumor was found to prolapse into and occlude the right coronary ostium , leading to an acute , recurring myocardial infarction . Histological examination of the grossly unremarkable conduction system of the heart revealed a cystic tumor in the region of the atrioventricular node . To our knowledge , this is the first report of coexistence of these two rare cardiac tumors .	[ "We", "describe", "a", "rare", "case", "of", "a", "papillary", "fibroelastoma", "of", "the", "aortic", "valve", "occurring", "simultaneously", "with", "a", "cystic", "tumor", "(", "a", "so", "-", "called", "mesothelioma", ")", "of", "the", "atrioventricular", "nodal", "region", ".", "At", "autopsy", "the", "tumor", "was", "found", "to", "prolapse", "into", "and", "occlude", "the", "right", "coronary", "ostium", ",", "leading", "to", "an", "acute", ",", "recurring", "myocardial", "infarction", ".", "Histological", "examination", "of", "the", "grossly", "unremarkable", "conduction", "system", "of", "the", "heart", "revealed", "a", "cystic", "tumor", "in", "the", "region", "of", "the", "atrioventricular", "node", ".", "To", "our", "knowledge", ",", "this", "is", "the", "first", "report", "of", "coexistence", "of", "these", "two", "rare", "cardiac", "tumors", "." ]	[ "umlsterm" ]
Tumoren is an umlsterm, Knochentumoren is an umlsterm, Archiv is an umlsterm, Knochentumoren is an umlsterm, Riesenzelltumoren is an umlsterm, Wissen is an umlsterm, Knochentumoren is an umlsterm, Techniken is an umlsterm, Tumoren is an umlsterm	DerRadiologe.80380467.ger.abstr_task0	Sentence: Osteosarkome Chondrosarkome und Tumoren , der Ewing-Gruppe sind die weitaus haeufigsten primaeren boesartigen Knochentumoren . In einer juengst eingerichteten Internet-Homepage des Orthopaedischen Spital Rizzoli in Bologna , die das Archiv dieser Institution seit dem Jahre 1900 wiedergibt , stellen diese Entitaeten den Grossteil von beobachteten malignen Knochentumoren dar . Seltener werden maligne fibroese Histiozytome , Fibrosarkome , Haemangioendotheliome , maligne Hemangioperizytome und Riesenzelltumoren diagnostiziert . Das Wissen ueber genetische Veraenderungen bei malignen Knochentumoren hat in den letzten Jahren durch den breiten Einsatz moderner molekularer und zytogenetischer Techniken stark zugenommen . Bisher konnte jedoch nur fuer Tumoren der Ewing-Gruppe ein konstant nachweisbares genetisches Merkmal identifiziert werden , das in einer fuer diese Erkrankung pathognomonischen chromosomalen Translokation t ( 11 ; 22 q24;q12) ) ( besteht . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Osteosarkome Chondrosarkome und Tumoren , der Ewing-Gruppe sind die weitaus haeufigsten primaeren boesartigen Knochentumoren . In einer juengst eingerichteten Internet-Homepage des Orthopaedischen Spital Rizzoli in Bologna , die das Archiv dieser Institution seit dem Jahre 1900 wiedergibt , stellen diese Entitaeten den Grossteil von beobachteten malignen Knochentumoren dar . Seltener werden maligne fibroese Histiozytome , Fibrosarkome , Haemangioendotheliome , maligne Hemangioperizytome und Riesenzelltumoren diagnostiziert . Das Wissen ueber genetische Veraenderungen bei malignen Knochentumoren hat in den letzten Jahren durch den breiten Einsatz moderner molekularer und zytogenetischer Techniken stark zugenommen . Bisher konnte jedoch nur fuer Tumoren der Ewing-Gruppe ein konstant nachweisbares genetisches Merkmal identifiziert werden , das in einer fuer diese Erkrankung pathognomonischen chromosomalen Translokation t ( 11 ; 22 q24;q12) ) ( besteht .	[ "Osteosarkome", "Chondrosarkome", "und", "Tumoren", ",", "der", "Ewing", "-", "Gruppe", "sind", "die", "weitaus", "haeufigsten", "primaeren", "boesartigen", "Knochentumoren", ".", "In", "einer", "juengst", "eingerichteten", "Internet", "-", "Homepage", "des", "Orthopaedischen", "Spital", "Rizzoli", "in", "Bologna", ",", "die", "das", "Archiv", "dieser", "Institution", "seit", "dem", "Jahre", "1900", "wiedergibt", ",", "stellen", "diese", "Entitaeten", "den", "Grossteil", "von", "beobachteten", "malignen", "Knochentumoren", "dar", ".", "Seltener", "werden", "maligne", "fibroese", "Histiozytome", ",", "Fibrosarkome", ",", "Haemangioendotheliome", ",", "maligne", "Hemangioperizytome", "und", "Riesenzelltumoren", "diagnostiziert", ".", "Das", "Wissen", "ueber", "genetische", "Veraenderungen", "bei", "malignen", "Knochentumoren", "hat", "in", "den", "letzten", "Jahren", "durch", "den", "breiten", "Einsatz", "moderner", "molekularer", "und", "zytogenetischer", "Techniken", "stark", "zugenommen", ".", "Bisher", "konnte", "jedoch", "nur", "fuer", "Tumoren", "der", "Ewing", "-", "Gruppe", "ein", "konstant", "nachweisbares", "genetisches", "Merkmal", "identifiziert", "werden", ",", "das", "in", "einer", "fuer", "diese", "Erkrankung", "pathognomonischen", "chromosomalen", "Translokation", "t", "(", "11", ";", "22", "q24;q12", ")", ")", "(", "besteht", "." ]	[ "umlsterm" ]
Tumoren is an umlsterm, Knochentumoren is an umlsterm, Archiv is an umlsterm, Knochentumoren is an umlsterm, Riesenzelltumoren is an umlsterm, Wissen is an umlsterm, Knochentumoren is an umlsterm, Techniken is an umlsterm, Tumoren is an umlsterm	DerRadiologe.80380467.ger.abstr_task1	Sentence: Osteosarkome Chondrosarkome und Tumoren , der Ewing-Gruppe sind die weitaus haeufigsten primaeren boesartigen Knochentumoren . In einer juengst eingerichteten Internet-Homepage des Orthopaedischen Spital Rizzoli in Bologna , die das Archiv dieser Institution seit dem Jahre 1900 wiedergibt , stellen diese Entitaeten den Grossteil von beobachteten malignen Knochentumoren dar . Seltener werden maligne fibroese Histiozytome , Fibrosarkome , Haemangioendotheliome , maligne Hemangioperizytome und Riesenzelltumoren diagnostiziert . Das Wissen ueber genetische Veraenderungen bei malignen Knochentumoren hat in den letzten Jahren durch den breiten Einsatz moderner molekularer und zytogenetischer Techniken stark zugenommen . Bisher konnte jedoch nur fuer Tumoren der Ewing-Gruppe ein konstant nachweisbares genetisches Merkmal identifiziert werden , das in einer fuer diese Erkrankung pathognomonischen chromosomalen Translokation t ( 11 ; 22 q24;q12) ) ( besteht . Instructions: please typing these entity words according to sentence: Tumoren, Knochentumoren, Archiv, Knochentumoren, Riesenzelltumoren, Wissen, Knochentumoren, Techniken, Tumoren Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Osteosarkome Chondrosarkome und Tumoren , der Ewing-Gruppe sind die weitaus haeufigsten primaeren boesartigen Knochentumoren . In einer juengst eingerichteten Internet-Homepage des Orthopaedischen Spital Rizzoli in Bologna , die das Archiv dieser Institution seit dem Jahre 1900 wiedergibt , stellen diese Entitaeten den Grossteil von beobachteten malignen Knochentumoren dar . Seltener werden maligne fibroese Histiozytome , Fibrosarkome , Haemangioendotheliome , maligne Hemangioperizytome und Riesenzelltumoren diagnostiziert . Das Wissen ueber genetische Veraenderungen bei malignen Knochentumoren hat in den letzten Jahren durch den breiten Einsatz moderner molekularer und zytogenetischer Techniken stark zugenommen . Bisher konnte jedoch nur fuer Tumoren der Ewing-Gruppe ein konstant nachweisbares genetisches Merkmal identifiziert werden , das in einer fuer diese Erkrankung pathognomonischen chromosomalen Translokation t ( 11 ; 22 q24;q12) ) ( besteht .	[ "Osteosarkome", "Chondrosarkome", "und", "Tumoren", ",", "der", "Ewing", "-", "Gruppe", "sind", "die", "weitaus", "haeufigsten", "primaeren", "boesartigen", "Knochentumoren", ".", "In", "einer", "juengst", "eingerichteten", "Internet", "-", "Homepage", "des", "Orthopaedischen", "Spital", "Rizzoli", "in", "Bologna", ",", "die", "das", "Archiv", "dieser", "Institution", "seit", "dem", "Jahre", "1900", "wiedergibt", ",", "stellen", "diese", "Entitaeten", "den", "Grossteil", "von", "beobachteten", "malignen", "Knochentumoren", "dar", ".", "Seltener", "werden", "maligne", "fibroese", "Histiozytome", ",", "Fibrosarkome", ",", "Haemangioendotheliome", ",", "maligne", "Hemangioperizytome", "und", "Riesenzelltumoren", "diagnostiziert", ".", "Das", "Wissen", "ueber", "genetische", "Veraenderungen", "bei", "malignen", "Knochentumoren", "hat", "in", "den", "letzten", "Jahren", "durch", "den", "breiten", "Einsatz", "moderner", "molekularer", "und", "zytogenetischer", "Techniken", "stark", "zugenommen", ".", "Bisher", "konnte", "jedoch", "nur", "fuer", "Tumoren", "der", "Ewing", "-", "Gruppe", "ein", "konstant", "nachweisbares", "genetisches", "Merkmal", "identifiziert", "werden", ",", "das", "in", "einer", "fuer", "diese", "Erkrankung", "pathognomonischen", "chromosomalen", "Translokation", "t", "(", "11", ";", "22", "q24;q12", ")", ")", "(", "besteht", "." ]	[ "umlsterm" ]
Tumoren, Knochentumoren, Archiv, Knochentumoren, Riesenzelltumoren, Wissen, Knochentumoren, Techniken, Tumoren	DerRadiologe.80380467.ger.abstr_task2	Sentence: Osteosarkome Chondrosarkome und Tumoren , der Ewing-Gruppe sind die weitaus haeufigsten primaeren boesartigen Knochentumoren . In einer juengst eingerichteten Internet-Homepage des Orthopaedischen Spital Rizzoli in Bologna , die das Archiv dieser Institution seit dem Jahre 1900 wiedergibt , stellen diese Entitaeten den Grossteil von beobachteten malignen Knochentumoren dar . Seltener werden maligne fibroese Histiozytome , Fibrosarkome , Haemangioendotheliome , maligne Hemangioperizytome und Riesenzelltumoren diagnostiziert . Das Wissen ueber genetische Veraenderungen bei malignen Knochentumoren hat in den letzten Jahren durch den breiten Einsatz moderner molekularer und zytogenetischer Techniken stark zugenommen . Bisher konnte jedoch nur fuer Tumoren der Ewing-Gruppe ein konstant nachweisbares genetisches Merkmal identifiziert werden , das in einer fuer diese Erkrankung pathognomonischen chromosomalen Translokation t ( 11 ; 22 q24;q12) ) ( besteht . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Osteosarkome Chondrosarkome und Tumoren , der Ewing-Gruppe sind die weitaus haeufigsten primaeren boesartigen Knochentumoren . In einer juengst eingerichteten Internet-Homepage des Orthopaedischen Spital Rizzoli in Bologna , die das Archiv dieser Institution seit dem Jahre 1900 wiedergibt , stellen diese Entitaeten den Grossteil von beobachteten malignen Knochentumoren dar . Seltener werden maligne fibroese Histiozytome , Fibrosarkome , Haemangioendotheliome , maligne Hemangioperizytome und Riesenzelltumoren diagnostiziert . Das Wissen ueber genetische Veraenderungen bei malignen Knochentumoren hat in den letzten Jahren durch den breiten Einsatz moderner molekularer und zytogenetischer Techniken stark zugenommen . Bisher konnte jedoch nur fuer Tumoren der Ewing-Gruppe ein konstant nachweisbares genetisches Merkmal identifiziert werden , das in einer fuer diese Erkrankung pathognomonischen chromosomalen Translokation t ( 11 ; 22 q24;q12) ) ( besteht .	[ "Osteosarkome", "Chondrosarkome", "und", "Tumoren", ",", "der", "Ewing", "-", "Gruppe", "sind", "die", "weitaus", "haeufigsten", "primaeren", "boesartigen", "Knochentumoren", ".", "In", "einer", "juengst", "eingerichteten", "Internet", "-", "Homepage", "des", "Orthopaedischen", "Spital", "Rizzoli", "in", "Bologna", ",", "die", "das", "Archiv", "dieser", "Institution", "seit", "dem", "Jahre", "1900", "wiedergibt", ",", "stellen", "diese", "Entitaeten", "den", "Grossteil", "von", "beobachteten", "malignen", "Knochentumoren", "dar", ".", "Seltener", "werden", "maligne", "fibroese", "Histiozytome", ",", "Fibrosarkome", ",", "Haemangioendotheliome", ",", "maligne", "Hemangioperizytome", "und", "Riesenzelltumoren", "diagnostiziert", ".", "Das", "Wissen", "ueber", "genetische", "Veraenderungen", "bei", "malignen", "Knochentumoren", "hat", "in", "den", "letzten", "Jahren", "durch", "den", "breiten", "Einsatz", "moderner", "molekularer", "und", "zytogenetischer", "Techniken", "stark", "zugenommen", ".", "Bisher", "konnte", "jedoch", "nur", "fuer", "Tumoren", "der", "Ewing", "-", "Gruppe", "ein", "konstant", "nachweisbares", "genetisches", "Merkmal", "identifiziert", "werden", ",", "das", "in", "einer", "fuer", "diese", "Erkrankung", "pathognomonischen", "chromosomalen", "Translokation", "t", "(", "11", ";", "22", "q24;q12", ")", ")", "(", "besteht", "." ]	[ "umlsterm" ]
EMG is an umlsterm, Methode is an umlsterm, EMG is an umlsterm, Blasensphinkter is an umlsterm, EMG is an umlsterm	DerUrologeA.70360356.ger.abstr_task0	Sentence: Elektrophysiologische Untersuchungen liefern wichtige Befunde in der Abklaerung urogenitaler Funktionsstoerungen . Zur Feststellung einer Schaedigung der somatomotorischen Strecke wird neben der Nervreizung des Pudendus das Elektromyogramm ( EMG ) vom M. sphincter ani externus routinemaessig abgeleitet . Alternativ kann auch der M. sphincter vesicae externus elektromyographisch untersucht werden . Der zeitliche Aufwand ist etwas hoeher , eine ausreichende Erfahrung mit dieser speziellen Methode ist unabdingbar . Wir sehen eine Indikation fuer das EMG vom willkuerlichen Blasensphinkter bei urogenitalen Funktionsstoerungen , die durch das EMG vom Analsphinkter nicht suffizient differenziert werden koennen , sowie bei Funktionsstoerungen die selektiv den M. sphincter vesicae externus betreffen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Elektrophysiologische Untersuchungen liefern wichtige Befunde in der Abklaerung urogenitaler Funktionsstoerungen . Zur Feststellung einer Schaedigung der somatomotorischen Strecke wird neben der Nervreizung des Pudendus das Elektromyogramm ( EMG ) vom M. sphincter ani externus routinemaessig abgeleitet . Alternativ kann auch der M. sphincter vesicae externus elektromyographisch untersucht werden . Der zeitliche Aufwand ist etwas hoeher , eine ausreichende Erfahrung mit dieser speziellen Methode ist unabdingbar . Wir sehen eine Indikation fuer das EMG vom willkuerlichen Blasensphinkter bei urogenitalen Funktionsstoerungen , die durch das EMG vom Analsphinkter nicht suffizient differenziert werden koennen , sowie bei Funktionsstoerungen die selektiv den M. sphincter vesicae externus betreffen .	[ "Elektrophysiologische", "Untersuchungen", "liefern", "wichtige", "Befunde", "in", "der", "Abklaerung", "urogenitaler", "Funktionsstoerungen", ".", "Zur", "Feststellung", "einer", "Schaedigung", "der", "somatomotorischen", "Strecke", "wird", "neben", "der", "Nervreizung", "des", "Pudendus", "das", "Elektromyogramm", "(", "EMG", ")", "vom", "M.", "sphincter", "ani", "externus", "routinemaessig", "abgeleitet", ".", "Alternativ", "kann", "auch", "der", "M.", "sphincter", "vesicae", "externus", "elektromyographisch", "untersucht", "werden", ".", "Der", "zeitliche", "Aufwand", "ist", "etwas", "hoeher", ",", "eine", "ausreichende", "Erfahrung", "mit", "dieser", "speziellen", "Methode", "ist", "unabdingbar", ".", "Wir", "sehen", "eine", "Indikation", "fuer", "das", "EMG", "vom", "willkuerlichen", "Blasensphinkter", "bei", "urogenitalen", "Funktionsstoerungen", ",", "die", "durch", "das", "EMG", "vom", "Analsphinkter", "nicht", "suffizient", "differenziert", "werden", "koennen", ",", "sowie", "bei", "Funktionsstoerungen", "die", "selektiv", "den", "M.", "sphincter", "vesicae", "externus", "betreffen", "." ]	[ "umlsterm" ]
EMG is an umlsterm, Methode is an umlsterm, EMG is an umlsterm, Blasensphinkter is an umlsterm, EMG is an umlsterm	DerUrologeA.70360356.ger.abstr_task1	Sentence: Elektrophysiologische Untersuchungen liefern wichtige Befunde in der Abklaerung urogenitaler Funktionsstoerungen . Zur Feststellung einer Schaedigung der somatomotorischen Strecke wird neben der Nervreizung des Pudendus das Elektromyogramm ( EMG ) vom M. sphincter ani externus routinemaessig abgeleitet . Alternativ kann auch der M. sphincter vesicae externus elektromyographisch untersucht werden . Der zeitliche Aufwand ist etwas hoeher , eine ausreichende Erfahrung mit dieser speziellen Methode ist unabdingbar . Wir sehen eine Indikation fuer das EMG vom willkuerlichen Blasensphinkter bei urogenitalen Funktionsstoerungen , die durch das EMG vom Analsphinkter nicht suffizient differenziert werden koennen , sowie bei Funktionsstoerungen die selektiv den M. sphincter vesicae externus betreffen . Instructions: please typing these entity words according to sentence: EMG, Methode, EMG, Blasensphinkter, EMG Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Elektrophysiologische Untersuchungen liefern wichtige Befunde in der Abklaerung urogenitaler Funktionsstoerungen . Zur Feststellung einer Schaedigung der somatomotorischen Strecke wird neben der Nervreizung des Pudendus das Elektromyogramm ( EMG ) vom M. sphincter ani externus routinemaessig abgeleitet . Alternativ kann auch der M. sphincter vesicae externus elektromyographisch untersucht werden . Der zeitliche Aufwand ist etwas hoeher , eine ausreichende Erfahrung mit dieser speziellen Methode ist unabdingbar . Wir sehen eine Indikation fuer das EMG vom willkuerlichen Blasensphinkter bei urogenitalen Funktionsstoerungen , die durch das EMG vom Analsphinkter nicht suffizient differenziert werden koennen , sowie bei Funktionsstoerungen die selektiv den M. sphincter vesicae externus betreffen .	[ "Elektrophysiologische", "Untersuchungen", "liefern", "wichtige", "Befunde", "in", "der", "Abklaerung", "urogenitaler", "Funktionsstoerungen", ".", "Zur", "Feststellung", "einer", "Schaedigung", "der", "somatomotorischen", "Strecke", "wird", "neben", "der", "Nervreizung", "des", "Pudendus", "das", "Elektromyogramm", "(", "EMG", ")", "vom", "M.", "sphincter", "ani", "externus", "routinemaessig", "abgeleitet", ".", "Alternativ", "kann", "auch", "der", "M.", "sphincter", "vesicae", "externus", "elektromyographisch", "untersucht", "werden", ".", "Der", "zeitliche", "Aufwand", "ist", "etwas", "hoeher", ",", "eine", "ausreichende", "Erfahrung", "mit", "dieser", "speziellen", "Methode", "ist", "unabdingbar", ".", "Wir", "sehen", "eine", "Indikation", "fuer", "das", "EMG", "vom", "willkuerlichen", "Blasensphinkter", "bei", "urogenitalen", "Funktionsstoerungen", ",", "die", "durch", "das", "EMG", "vom", "Analsphinkter", "nicht", "suffizient", "differenziert", "werden", "koennen", ",", "sowie", "bei", "Funktionsstoerungen", "die", "selektiv", "den", "M.", "sphincter", "vesicae", "externus", "betreffen", "." ]	[ "umlsterm" ]
EMG, Methode, EMG, Blasensphinkter, EMG	DerUrologeA.70360356.ger.abstr_task2	Sentence: Elektrophysiologische Untersuchungen liefern wichtige Befunde in der Abklaerung urogenitaler Funktionsstoerungen . Zur Feststellung einer Schaedigung der somatomotorischen Strecke wird neben der Nervreizung des Pudendus das Elektromyogramm ( EMG ) vom M. sphincter ani externus routinemaessig abgeleitet . Alternativ kann auch der M. sphincter vesicae externus elektromyographisch untersucht werden . Der zeitliche Aufwand ist etwas hoeher , eine ausreichende Erfahrung mit dieser speziellen Methode ist unabdingbar . Wir sehen eine Indikation fuer das EMG vom willkuerlichen Blasensphinkter bei urogenitalen Funktionsstoerungen , die durch das EMG vom Analsphinkter nicht suffizient differenziert werden koennen , sowie bei Funktionsstoerungen die selektiv den M. sphincter vesicae externus betreffen . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Elektrophysiologische Untersuchungen liefern wichtige Befunde in der Abklaerung urogenitaler Funktionsstoerungen . Zur Feststellung einer Schaedigung der somatomotorischen Strecke wird neben der Nervreizung des Pudendus das Elektromyogramm ( EMG ) vom M. sphincter ani externus routinemaessig abgeleitet . Alternativ kann auch der M. sphincter vesicae externus elektromyographisch untersucht werden . Der zeitliche Aufwand ist etwas hoeher , eine ausreichende Erfahrung mit dieser speziellen Methode ist unabdingbar . Wir sehen eine Indikation fuer das EMG vom willkuerlichen Blasensphinkter bei urogenitalen Funktionsstoerungen , die durch das EMG vom Analsphinkter nicht suffizient differenziert werden koennen , sowie bei Funktionsstoerungen die selektiv den M. sphincter vesicae externus betreffen .	[ "Elektrophysiologische", "Untersuchungen", "liefern", "wichtige", "Befunde", "in", "der", "Abklaerung", "urogenitaler", "Funktionsstoerungen", ".", "Zur", "Feststellung", "einer", "Schaedigung", "der", "somatomotorischen", "Strecke", "wird", "neben", "der", "Nervreizung", "des", "Pudendus", "das", "Elektromyogramm", "(", "EMG", ")", "vom", "M.", "sphincter", "ani", "externus", "routinemaessig", "abgeleitet", ".", "Alternativ", "kann", "auch", "der", "M.", "sphincter", "vesicae", "externus", "elektromyographisch", "untersucht", "werden", ".", "Der", "zeitliche", "Aufwand", "ist", "etwas", "hoeher", ",", "eine", "ausreichende", "Erfahrung", "mit", "dieser", "speziellen", "Methode", "ist", "unabdingbar", ".", "Wir", "sehen", "eine", "Indikation", "fuer", "das", "EMG", "vom", "willkuerlichen", "Blasensphinkter", "bei", "urogenitalen", "Funktionsstoerungen", ",", "die", "durch", "das", "EMG", "vom", "Analsphinkter", "nicht", "suffizient", "differenziert", "werden", "koennen", ",", "sowie", "bei", "Funktionsstoerungen", "die", "selektiv", "den", "M.", "sphincter", "vesicae", "externus", "betreffen", "." ]	[ "umlsterm" ]
Caffeine is a CHEMICAL, kinase is a GENE-N, ATM is a GENE-Y	10531013_task0	Sentence: Caffeine inhibits the checkpoint kinase ATM. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, GENE-N, CHEMICAL	[ "B-CHEMICAL", "O", "O", "O", "B-GENE-N", "B-GENE-Y", "O" ]	Caffeine inhibits the checkpoint kinase ATM.	[ "Caffeine", "inhibits", "the", "checkpoint", "kinase", "ATM", "." ]	[ "CHEMICAL", "GENE-N", "GENE-Y" ]
Caffeine is a CHEMICAL, kinase is a GENE-N, ATM is a GENE-Y	10531013_task1	Sentence: Caffeine inhibits the checkpoint kinase ATM. Instructions: please typing these entity words according to sentence: Caffeine, kinase, ATM Options: GENE-Y, GENE-N, CHEMICAL	[ "B-CHEMICAL", "O", "O", "O", "B-GENE-N", "B-GENE-Y", "O" ]	Caffeine inhibits the checkpoint kinase ATM.	[ "Caffeine", "inhibits", "the", "checkpoint", "kinase", "ATM", "." ]	[ "CHEMICAL", "GENE-N", "GENE-Y" ]
Caffeine, kinase, ATM	10531013_task2	Sentence: Caffeine inhibits the checkpoint kinase ATM. Instructions: please extract entity words from the input sentence	[ "B-CHEMICAL", "O", "O", "O", "B-GENE-N", "B-GENE-Y", "O" ]	Caffeine inhibits the checkpoint kinase ATM.	[ "Caffeine", "inhibits", "the", "checkpoint", "kinase", "ATM", "." ]	[ "CHEMICAL", "GENE-N", "GENE-Y" ]
Tetracycline is a DRUG, bacteriostatic antibiotic is a GROUP, penicillin is a DRUG	Nafcillin_ddi_task0	Sentence: Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin and concurrent use of these drugs should be avoided. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GROUP, DRUG	[ "B-DRUG", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin and concurrent use of these drugs should be avoided.	[ "Tetracycline", ",", "a", "bacteriostatic", "antibiotic", ",", "may", "antagonize", "the", "bactericidal", "effect", "of", "penicillin", "and", "concurrent", "use", "of", "these", "drugs", "should", "be", "avoided", "." ]	[ "GROUP", "DRUG" ]
Tetracycline is a DRUG, bacteriostatic antibiotic is a GROUP, penicillin is a DRUG	Nafcillin_ddi_task1	Sentence: Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin and concurrent use of these drugs should be avoided. Instructions: please typing these entity words according to sentence: Tetracycline, bacteriostatic antibiotic, penicillin Options: GROUP, DRUG	[ "B-DRUG", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin and concurrent use of these drugs should be avoided.	[ "Tetracycline", ",", "a", "bacteriostatic", "antibiotic", ",", "may", "antagonize", "the", "bactericidal", "effect", "of", "penicillin", "and", "concurrent", "use", "of", "these", "drugs", "should", "be", "avoided", "." ]	[ "GROUP", "DRUG" ]
Tetracycline, bacteriostatic antibiotic, penicillin	Nafcillin_ddi_task2	Sentence: Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin and concurrent use of these drugs should be avoided. Instructions: please extract entity words from the input sentence	[ "B-DRUG", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin and concurrent use of these drugs should be avoided.	[ "Tetracycline", ",", "a", "bacteriostatic", "antibiotic", ",", "may", "antagonize", "the", "bactericidal", "effect", "of", "penicillin", "and", "concurrent", "use", "of", "these", "drugs", "should", "be", "avoided", "." ]	[ "GROUP", "DRUG" ]
Neugeborenes is an umlsterm, Geburtsgewicht is an umlsterm, Therapie is an umlsterm, Digitalis is an umlsterm, Diuretika is an umlsterm, Behandlung is an umlsterm, Lebenstag is an umlsterm, Therapie is an umlsterm, Tumorgefaesse is an umlsterm, Patienten is an umlsterm, Tumors is an umlsterm	ZfuerKardiologie.80870832.ger.abstr_task0	Sentence: Wir berichten ueber ein Neugeborenes ( Geburtsgewicht 3660 g ) , welches postpartal wegen eines hepatischen Haemangioendothelioms und dem damit verbundenen arteriovenoesen Shuntvolumen kardiorespiratorisch dekompensierte . Eine Therapie der Herzinsuffizienz mit Digitalis und Diuretika sowie eine Behandlung mit Kortikosteroiden wurde am 1. Lebenstag begonnen , konnte die Symptomatik jedoch nicht verbessern . Aus diesem Grund wurde eine interventionelle Therapie des Haemangioendothelioms mittels Coil-Okklusion der arteriellen Tumorgefaesse durchgefuehrt . Die Symptomatik des Patienten besserte sich daraufhin rasch , er konnte 4 Tage nach der Embolisation extubiert werden . Die sonographische Kontrolle nach 4 Monaten zeigte eine deutliche Regression des Tumors . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Wir berichten ueber ein Neugeborenes ( Geburtsgewicht 3660 g ) , welches postpartal wegen eines hepatischen Haemangioendothelioms und dem damit verbundenen arteriovenoesen Shuntvolumen kardiorespiratorisch dekompensierte . Eine Therapie der Herzinsuffizienz mit Digitalis und Diuretika sowie eine Behandlung mit Kortikosteroiden wurde am 1. Lebenstag begonnen , konnte die Symptomatik jedoch nicht verbessern . Aus diesem Grund wurde eine interventionelle Therapie des Haemangioendothelioms mittels Coil-Okklusion der arteriellen Tumorgefaesse durchgefuehrt . Die Symptomatik des Patienten besserte sich daraufhin rasch , er konnte 4 Tage nach der Embolisation extubiert werden . Die sonographische Kontrolle nach 4 Monaten zeigte eine deutliche Regression des Tumors .	[ "Wir", "berichten", "ueber", "ein", "Neugeborenes", "(", "Geburtsgewicht", "3660", "g", ")", ",", "welches", "postpartal", "wegen", "eines", "hepatischen", "Haemangioendothelioms", "und", "dem", "damit", "verbundenen", "arteriovenoesen", "Shuntvolumen", "kardiorespiratorisch", "dekompensierte", ".", "Eine", "Therapie", "der", "Herzinsuffizienz", "mit", "Digitalis", "und", "Diuretika", "sowie", "eine", "Behandlung", "mit", "Kortikosteroiden", "wurde", "am", "1", ".", "Lebenstag", "begonnen", ",", "konnte", "die", "Symptomatik", "jedoch", "nicht", "verbessern", ".", "Aus", "diesem", "Grund", "wurde", "eine", "interventionelle", "Therapie", "des", "Haemangioendothelioms", "mittels", "Coil", "-", "Okklusion", "der", "arteriellen", "Tumorgefaesse", "durchgefuehrt", ".", "Die", "Symptomatik", "des", "Patienten", "besserte", "sich", "daraufhin", "rasch", ",", "er", "konnte", "4", "Tage", "nach", "der", "Embolisation", "extubiert", "werden", ".", "Die", "sonographische", "Kontrolle", "nach", "4", "Monaten", "zeigte", "eine", "deutliche", "Regression", "des", "Tumors", "." ]	[ "umlsterm" ]
Neugeborenes is an umlsterm, Geburtsgewicht is an umlsterm, Therapie is an umlsterm, Digitalis is an umlsterm, Diuretika is an umlsterm, Behandlung is an umlsterm, Lebenstag is an umlsterm, Therapie is an umlsterm, Tumorgefaesse is an umlsterm, Patienten is an umlsterm, Tumors is an umlsterm	ZfuerKardiologie.80870832.ger.abstr_task1	Sentence: Wir berichten ueber ein Neugeborenes ( Geburtsgewicht 3660 g ) , welches postpartal wegen eines hepatischen Haemangioendothelioms und dem damit verbundenen arteriovenoesen Shuntvolumen kardiorespiratorisch dekompensierte . Eine Therapie der Herzinsuffizienz mit Digitalis und Diuretika sowie eine Behandlung mit Kortikosteroiden wurde am 1. Lebenstag begonnen , konnte die Symptomatik jedoch nicht verbessern . Aus diesem Grund wurde eine interventionelle Therapie des Haemangioendothelioms mittels Coil-Okklusion der arteriellen Tumorgefaesse durchgefuehrt . Die Symptomatik des Patienten besserte sich daraufhin rasch , er konnte 4 Tage nach der Embolisation extubiert werden . Die sonographische Kontrolle nach 4 Monaten zeigte eine deutliche Regression des Tumors . Instructions: please typing these entity words according to sentence: Neugeborenes, Geburtsgewicht, Therapie, Digitalis, Diuretika, Behandlung, Lebenstag, Therapie, Tumorgefaesse, Patienten, Tumors Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Wir berichten ueber ein Neugeborenes ( Geburtsgewicht 3660 g ) , welches postpartal wegen eines hepatischen Haemangioendothelioms und dem damit verbundenen arteriovenoesen Shuntvolumen kardiorespiratorisch dekompensierte . Eine Therapie der Herzinsuffizienz mit Digitalis und Diuretika sowie eine Behandlung mit Kortikosteroiden wurde am 1. Lebenstag begonnen , konnte die Symptomatik jedoch nicht verbessern . Aus diesem Grund wurde eine interventionelle Therapie des Haemangioendothelioms mittels Coil-Okklusion der arteriellen Tumorgefaesse durchgefuehrt . Die Symptomatik des Patienten besserte sich daraufhin rasch , er konnte 4 Tage nach der Embolisation extubiert werden . Die sonographische Kontrolle nach 4 Monaten zeigte eine deutliche Regression des Tumors .	[ "Wir", "berichten", "ueber", "ein", "Neugeborenes", "(", "Geburtsgewicht", "3660", "g", ")", ",", "welches", "postpartal", "wegen", "eines", "hepatischen", "Haemangioendothelioms", "und", "dem", "damit", "verbundenen", "arteriovenoesen", "Shuntvolumen", "kardiorespiratorisch", "dekompensierte", ".", "Eine", "Therapie", "der", "Herzinsuffizienz", "mit", "Digitalis", "und", "Diuretika", "sowie", "eine", "Behandlung", "mit", "Kortikosteroiden", "wurde", "am", "1", ".", "Lebenstag", "begonnen", ",", "konnte", "die", "Symptomatik", "jedoch", "nicht", "verbessern", ".", "Aus", "diesem", "Grund", "wurde", "eine", "interventionelle", "Therapie", "des", "Haemangioendothelioms", "mittels", "Coil", "-", "Okklusion", "der", "arteriellen", "Tumorgefaesse", "durchgefuehrt", ".", "Die", "Symptomatik", "des", "Patienten", "besserte", "sich", "daraufhin", "rasch", ",", "er", "konnte", "4", "Tage", "nach", "der", "Embolisation", "extubiert", "werden", ".", "Die", "sonographische", "Kontrolle", "nach", "4", "Monaten", "zeigte", "eine", "deutliche", "Regression", "des", "Tumors", "." ]	[ "umlsterm" ]
Neugeborenes, Geburtsgewicht, Therapie, Digitalis, Diuretika, Behandlung, Lebenstag, Therapie, Tumorgefaesse, Patienten, Tumors	ZfuerKardiologie.80870832.ger.abstr_task2	Sentence: Wir berichten ueber ein Neugeborenes ( Geburtsgewicht 3660 g ) , welches postpartal wegen eines hepatischen Haemangioendothelioms und dem damit verbundenen arteriovenoesen Shuntvolumen kardiorespiratorisch dekompensierte . Eine Therapie der Herzinsuffizienz mit Digitalis und Diuretika sowie eine Behandlung mit Kortikosteroiden wurde am 1. Lebenstag begonnen , konnte die Symptomatik jedoch nicht verbessern . Aus diesem Grund wurde eine interventionelle Therapie des Haemangioendothelioms mittels Coil-Okklusion der arteriellen Tumorgefaesse durchgefuehrt . Die Symptomatik des Patienten besserte sich daraufhin rasch , er konnte 4 Tage nach der Embolisation extubiert werden . Die sonographische Kontrolle nach 4 Monaten zeigte eine deutliche Regression des Tumors . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Wir berichten ueber ein Neugeborenes ( Geburtsgewicht 3660 g ) , welches postpartal wegen eines hepatischen Haemangioendothelioms und dem damit verbundenen arteriovenoesen Shuntvolumen kardiorespiratorisch dekompensierte . Eine Therapie der Herzinsuffizienz mit Digitalis und Diuretika sowie eine Behandlung mit Kortikosteroiden wurde am 1. Lebenstag begonnen , konnte die Symptomatik jedoch nicht verbessern . Aus diesem Grund wurde eine interventionelle Therapie des Haemangioendothelioms mittels Coil-Okklusion der arteriellen Tumorgefaesse durchgefuehrt . Die Symptomatik des Patienten besserte sich daraufhin rasch , er konnte 4 Tage nach der Embolisation extubiert werden . Die sonographische Kontrolle nach 4 Monaten zeigte eine deutliche Regression des Tumors .	[ "Wir", "berichten", "ueber", "ein", "Neugeborenes", "(", "Geburtsgewicht", "3660", "g", ")", ",", "welches", "postpartal", "wegen", "eines", "hepatischen", "Haemangioendothelioms", "und", "dem", "damit", "verbundenen", "arteriovenoesen", "Shuntvolumen", "kardiorespiratorisch", "dekompensierte", ".", "Eine", "Therapie", "der", "Herzinsuffizienz", "mit", "Digitalis", "und", "Diuretika", "sowie", "eine", "Behandlung", "mit", "Kortikosteroiden", "wurde", "am", "1", ".", "Lebenstag", "begonnen", ",", "konnte", "die", "Symptomatik", "jedoch", "nicht", "verbessern", ".", "Aus", "diesem", "Grund", "wurde", "eine", "interventionelle", "Therapie", "des", "Haemangioendothelioms", "mittels", "Coil", "-", "Okklusion", "der", "arteriellen", "Tumorgefaesse", "durchgefuehrt", ".", "Die", "Symptomatik", "des", "Patienten", "besserte", "sich", "daraufhin", "rasch", ",", "er", "konnte", "4", "Tage", "nach", "der", "Embolisation", "extubiert", "werden", ".", "Die", "sonographische", "Kontrolle", "nach", "4", "Monaten", "zeigte", "eine", "deutliche", "Regression", "des", "Tumors", "." ]	[ "umlsterm" ]
aim is an umlsterm, treatment is an umlsterm, radius fractures is an umlsterm	DerChirurg.90701315.eng.abstr_task0	Sentence: Introduction : The aim of our study was to evaluate external fixation in the treatment of unstable distal radius fractures in a long-term follow-up . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Introduction : The aim of our study was to evaluate external fixation in the treatment of unstable distal radius fractures in a long-term follow-up .	[ "Introduction", ":", "The", "aim", "of", "our", "study", "was", "to", "evaluate", "external", "fixation", "in", "the", "treatment", "of", "unstable", "distal", "radius", "fractures", "in", "a", "long", "-", "term", "follow", "-", "up", "." ]	[ "umlsterm" ]
aim is an umlsterm, treatment is an umlsterm, radius fractures is an umlsterm	DerChirurg.90701315.eng.abstr_task1	Sentence: Introduction : The aim of our study was to evaluate external fixation in the treatment of unstable distal radius fractures in a long-term follow-up . Instructions: please typing these entity words according to sentence: aim, treatment, radius fractures Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Introduction : The aim of our study was to evaluate external fixation in the treatment of unstable distal radius fractures in a long-term follow-up .	[ "Introduction", ":", "The", "aim", "of", "our", "study", "was", "to", "evaluate", "external", "fixation", "in", "the", "treatment", "of", "unstable", "distal", "radius", "fractures", "in", "a", "long", "-", "term", "follow", "-", "up", "." ]	[ "umlsterm" ]
aim, treatment, radius fractures	DerChirurg.90701315.eng.abstr_task2	Sentence: Introduction : The aim of our study was to evaluate external fixation in the treatment of unstable distal radius fractures in a long-term follow-up . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Introduction : The aim of our study was to evaluate external fixation in the treatment of unstable distal radius fractures in a long-term follow-up .	[ "Introduction", ":", "The", "aim", "of", "our", "study", "was", "to", "evaluate", "external", "fixation", "in", "the", "treatment", "of", "unstable", "distal", "radius", "fractures", "in", "a", "long", "-", "term", "follow", "-", "up", "." ]	[ "umlsterm" ]
analgesia is an umlsterm, postoperative is an umlsterm, morbidity is an umlsterm, mortality is an umlsterm, epidural anaesthesia is an umlsterm, pain is an umlsterm, epidural analgesia is an umlsterm, stress is an umlsterm, postoperative is an umlsterm, morbidity is an umlsterm, mortality is an umlsterm, patients is an umlsterm, vascular surgery is an umlsterm, epidural anaesthesia is an umlsterm, postoperative is an umlsterm, hypercoagulability is an umlsterm, patients is an umlsterm, complications is an umlsterm, risk of is an umlsterm, re - operation is an umlsterm, regional anaesthesia is an umlsterm, morbidity is an umlsterm, overall is an umlsterm, mortality is an umlsterm, clinical studies is an umlsterm, finding is an umlsterm, postoperative pain is an umlsterm, surgical is an umlsterm, care is an umlsterm, therapeutic is an umlsterm, patient is an umlsterm, analgesia is an umlsterm, early mobilisation is an umlsterm, enteral feeding is an umlsterm	DerAnaesthesist.7046s187.eng.abstr_task0	Sentence: Effects of anaesthesia and analgesia on postoperative morbidity and mortality remain controversial . Numerous studies have demonstrated that epidural anaesthesia and pain relief by epidural analgesia reduces perioperative stress responses and thus may reduce postoperative morbidity and mortality . In patients undergoing vascular surgery , epidural anaesthesia diminished postoperative hypercoagulability . These patients may benefit from less thromboembolic complications as well as a reduced risk of a re-operation . However , regional anaesthesia does not affect cardiopulmonary morbidity or overall mortality significantly in most clinical studies . One reason for this disappointing finding may be the missing integration of improved postoperative pain relief into general surgical care . A multimodal therapeutic approach , which consists of preoperativ patient information , sufficient analgesia , early mobilisation and enteral feeding , may solve this discrepancy . Therefore , prospective controlled studies are needed to assess the influence of this perioperative approach on outcome . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Effects of anaesthesia and analgesia on postoperative morbidity and mortality remain controversial . Numerous studies have demonstrated that epidural anaesthesia and pain relief by epidural analgesia reduces perioperative stress responses and thus may reduce postoperative morbidity and mortality . In patients undergoing vascular surgery , epidural anaesthesia diminished postoperative hypercoagulability . These patients may benefit from less thromboembolic complications as well as a reduced risk of a re-operation . However , regional anaesthesia does not affect cardiopulmonary morbidity or overall mortality significantly in most clinical studies . One reason for this disappointing finding may be the missing integration of improved postoperative pain relief into general surgical care . A multimodal therapeutic approach , which consists of preoperativ patient information , sufficient analgesia , early mobilisation and enteral feeding , may solve this discrepancy . Therefore , prospective controlled studies are needed to assess the influence of this perioperative approach on outcome .	[ "Effects", "of", "anaesthesia", "and", "analgesia", "on", "postoperative", "morbidity", "and", "mortality", "remain", "controversial", ".", "Numerous", "studies", "have", "demonstrated", "that", "epidural", "anaesthesia", "and", "pain", "relief", "by", "epidural", "analgesia", "reduces", "perioperative", "stress", "responses", "and", "thus", "may", "reduce", "postoperative", "morbidity", "and", "mortality", ".", "In", "patients", "undergoing", "vascular", "surgery", ",", "epidural", "anaesthesia", "diminished", "postoperative", "hypercoagulability", ".", "These", "patients", "may", "benefit", "from", "less", "thromboembolic", "complications", "as", "well", "as", "a", "reduced", "risk", "of", "a", "re", "-", "operation", ".", "However", ",", "regional", "anaesthesia", "does", "not", "affect", "cardiopulmonary", "morbidity", "or", "overall", "mortality", "significantly", "in", "most", "clinical", "studies", ".", "One", "reason", "for", "this", "disappointing", "finding", "may", "be", "the", "missing", "integration", "of", "improved", "postoperative", "pain", "relief", "into", "general", "surgical", "care", ".", "A", "multimodal", "therapeutic", "approach", ",", "which", "consists", "of", "preoperativ", "patient", "information", ",", "sufficient", "analgesia", ",", "early", "mobilisation", "and", "enteral", "feeding", ",", "may", "solve", "this", "discrepancy", ".", "Therefore", ",", "prospective", "controlled", "studies", "are", "needed", "to", "assess", "the", "influence", "of", "this", "perioperative", "approach", "on", "outcome", "." ]	[ "umlsterm" ]
analgesia is an umlsterm, postoperative is an umlsterm, morbidity is an umlsterm, mortality is an umlsterm, epidural anaesthesia is an umlsterm, pain is an umlsterm, epidural analgesia is an umlsterm, stress is an umlsterm, postoperative is an umlsterm, morbidity is an umlsterm, mortality is an umlsterm, patients is an umlsterm, vascular surgery is an umlsterm, epidural anaesthesia is an umlsterm, postoperative is an umlsterm, hypercoagulability is an umlsterm, patients is an umlsterm, complications is an umlsterm, risk of is an umlsterm, re - operation is an umlsterm, regional anaesthesia is an umlsterm, morbidity is an umlsterm, overall is an umlsterm, mortality is an umlsterm, clinical studies is an umlsterm, finding is an umlsterm, postoperative pain is an umlsterm, surgical is an umlsterm, care is an umlsterm, therapeutic is an umlsterm, patient is an umlsterm, analgesia is an umlsterm, early mobilisation is an umlsterm, enteral feeding is an umlsterm	DerAnaesthesist.7046s187.eng.abstr_task1	Sentence: Effects of anaesthesia and analgesia on postoperative morbidity and mortality remain controversial . Numerous studies have demonstrated that epidural anaesthesia and pain relief by epidural analgesia reduces perioperative stress responses and thus may reduce postoperative morbidity and mortality . In patients undergoing vascular surgery , epidural anaesthesia diminished postoperative hypercoagulability . These patients may benefit from less thromboembolic complications as well as a reduced risk of a re-operation . However , regional anaesthesia does not affect cardiopulmonary morbidity or overall mortality significantly in most clinical studies . One reason for this disappointing finding may be the missing integration of improved postoperative pain relief into general surgical care . A multimodal therapeutic approach , which consists of preoperativ patient information , sufficient analgesia , early mobilisation and enteral feeding , may solve this discrepancy . Therefore , prospective controlled studies are needed to assess the influence of this perioperative approach on outcome . Instructions: please typing these entity words according to sentence: analgesia, postoperative, morbidity, mortality, epidural anaesthesia, pain, epidural analgesia, stress, postoperative, morbidity, mortality, patients, vascular surgery, epidural anaesthesia, postoperative, hypercoagulability, patients, complications, risk of, re - operation, regional anaesthesia, morbidity, overall, mortality, clinical studies, finding, postoperative pain, surgical, care, therapeutic, patient, analgesia, early mobilisation, enteral feeding Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Effects of anaesthesia and analgesia on postoperative morbidity and mortality remain controversial . Numerous studies have demonstrated that epidural anaesthesia and pain relief by epidural analgesia reduces perioperative stress responses and thus may reduce postoperative morbidity and mortality . In patients undergoing vascular surgery , epidural anaesthesia diminished postoperative hypercoagulability . These patients may benefit from less thromboembolic complications as well as a reduced risk of a re-operation . However , regional anaesthesia does not affect cardiopulmonary morbidity or overall mortality significantly in most clinical studies . One reason for this disappointing finding may be the missing integration of improved postoperative pain relief into general surgical care . A multimodal therapeutic approach , which consists of preoperativ patient information , sufficient analgesia , early mobilisation and enteral feeding , may solve this discrepancy . Therefore , prospective controlled studies are needed to assess the influence of this perioperative approach on outcome .	[ "Effects", "of", "anaesthesia", "and", "analgesia", "on", "postoperative", "morbidity", "and", "mortality", "remain", "controversial", ".", "Numerous", "studies", "have", "demonstrated", "that", "epidural", "anaesthesia", "and", "pain", "relief", "by", "epidural", "analgesia", "reduces", "perioperative", "stress", "responses", "and", "thus", "may", "reduce", "postoperative", "morbidity", "and", "mortality", ".", "In", "patients", "undergoing", "vascular", "surgery", ",", "epidural", "anaesthesia", "diminished", "postoperative", "hypercoagulability", ".", "These", "patients", "may", "benefit", "from", "less", "thromboembolic", "complications", "as", "well", "as", "a", "reduced", "risk", "of", "a", "re", "-", "operation", ".", "However", ",", "regional", "anaesthesia", "does", "not", "affect", "cardiopulmonary", "morbidity", "or", "overall", "mortality", "significantly", "in", "most", "clinical", "studies", ".", "One", "reason", "for", "this", "disappointing", "finding", "may", "be", "the", "missing", "integration", "of", "improved", "postoperative", "pain", "relief", "into", "general", "surgical", "care", ".", "A", "multimodal", "therapeutic", "approach", ",", "which", "consists", "of", "preoperativ", "patient", "information", ",", "sufficient", "analgesia", ",", "early", "mobilisation", "and", "enteral", "feeding", ",", "may", "solve", "this", "discrepancy", ".", "Therefore", ",", "prospective", "controlled", "studies", "are", "needed", "to", "assess", "the", "influence", "of", "this", "perioperative", "approach", "on", "outcome", "." ]	[ "umlsterm" ]
analgesia, postoperative, morbidity, mortality, epidural anaesthesia, pain, epidural analgesia, stress, postoperative, morbidity, mortality, patients, vascular surgery, epidural anaesthesia, postoperative, hypercoagulability, patients, complications, risk of, re - operation, regional anaesthesia, morbidity, overall, mortality, clinical studies, finding, postoperative pain, surgical, care, therapeutic, patient, analgesia, early mobilisation, enteral feeding	DerAnaesthesist.7046s187.eng.abstr_task2	Sentence: Effects of anaesthesia and analgesia on postoperative morbidity and mortality remain controversial . Numerous studies have demonstrated that epidural anaesthesia and pain relief by epidural analgesia reduces perioperative stress responses and thus may reduce postoperative morbidity and mortality . In patients undergoing vascular surgery , epidural anaesthesia diminished postoperative hypercoagulability . These patients may benefit from less thromboembolic complications as well as a reduced risk of a re-operation . However , regional anaesthesia does not affect cardiopulmonary morbidity or overall mortality significantly in most clinical studies . One reason for this disappointing finding may be the missing integration of improved postoperative pain relief into general surgical care . A multimodal therapeutic approach , which consists of preoperativ patient information , sufficient analgesia , early mobilisation and enteral feeding , may solve this discrepancy . Therefore , prospective controlled studies are needed to assess the influence of this perioperative approach on outcome . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Effects of anaesthesia and analgesia on postoperative morbidity and mortality remain controversial . Numerous studies have demonstrated that epidural anaesthesia and pain relief by epidural analgesia reduces perioperative stress responses and thus may reduce postoperative morbidity and mortality . In patients undergoing vascular surgery , epidural anaesthesia diminished postoperative hypercoagulability . These patients may benefit from less thromboembolic complications as well as a reduced risk of a re-operation . However , regional anaesthesia does not affect cardiopulmonary morbidity or overall mortality significantly in most clinical studies . One reason for this disappointing finding may be the missing integration of improved postoperative pain relief into general surgical care . A multimodal therapeutic approach , which consists of preoperativ patient information , sufficient analgesia , early mobilisation and enteral feeding , may solve this discrepancy . Therefore , prospective controlled studies are needed to assess the influence of this perioperative approach on outcome .	[ "Effects", "of", "anaesthesia", "and", "analgesia", "on", "postoperative", "morbidity", "and", "mortality", "remain", "controversial", ".", "Numerous", "studies", "have", "demonstrated", "that", "epidural", "anaesthesia", "and", "pain", "relief", "by", "epidural", "analgesia", "reduces", "perioperative", "stress", "responses", "and", "thus", "may", "reduce", "postoperative", "morbidity", "and", "mortality", ".", "In", "patients", "undergoing", "vascular", "surgery", ",", "epidural", "anaesthesia", "diminished", "postoperative", "hypercoagulability", ".", "These", "patients", "may", "benefit", "from", "less", "thromboembolic", "complications", "as", "well", "as", "a", "reduced", "risk", "of", "a", "re", "-", "operation", ".", "However", ",", "regional", "anaesthesia", "does", "not", "affect", "cardiopulmonary", "morbidity", "or", "overall", "mortality", "significantly", "in", "most", "clinical", "studies", ".", "One", "reason", "for", "this", "disappointing", "finding", "may", "be", "the", "missing", "integration", "of", "improved", "postoperative", "pain", "relief", "into", "general", "surgical", "care", ".", "A", "multimodal", "therapeutic", "approach", ",", "which", "consists", "of", "preoperativ", "patient", "information", ",", "sufficient", "analgesia", ",", "early", "mobilisation", "and", "enteral", "feeding", ",", "may", "solve", "this", "discrepancy", ".", "Therefore", ",", "prospective", "controlled", "studies", "are", "needed", "to", "assess", "the", "influence", "of", "this", "perioperative", "approach", "on", "outcome", "." ]	[ "umlsterm" ]
glucagon - like peptide-1 is a GENE-Y	23203941_task0	Sentence: Synthesis, characterization and pharmacodynamics of vitamin-B(12)-conjugated glucagon-like peptide-1. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O" ]	Synthesis, characterization and pharmacodynamics of vitamin-B(12)-conjugated glucagon-like peptide-1.	[ "Synthesis", ",", "characterization", "and", "pharmacodynamics", "of", "vitamin", "-", "B(12)-conjugated", "glucagon", "-", "like", "peptide-1", "." ]	[ "GENE-Y", "CHEMICAL" ]
glucagon - like peptide-1 is a GENE-Y	23203941_task1	Sentence: Synthesis, characterization and pharmacodynamics of vitamin-B(12)-conjugated glucagon-like peptide-1. Instructions: please typing these entity words according to sentence: glucagon - like peptide-1 Options: GENE-Y	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O" ]	Synthesis, characterization and pharmacodynamics of vitamin-B(12)-conjugated glucagon-like peptide-1.	[ "Synthesis", ",", "characterization", "and", "pharmacodynamics", "of", "vitamin", "-", "B(12)-conjugated", "glucagon", "-", "like", "peptide-1", "." ]	[ "GENE-Y", "CHEMICAL" ]
glucagon - like peptide-1	23203941_task2	Sentence: Synthesis, characterization and pharmacodynamics of vitamin-B(12)-conjugated glucagon-like peptide-1. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O" ]	Synthesis, characterization and pharmacodynamics of vitamin-B(12)-conjugated glucagon-like peptide-1.	[ "Synthesis", ",", "characterization", "and", "pharmacodynamics", "of", "vitamin", "-", "B(12)-conjugated", "glucagon", "-", "like", "peptide-1", "." ]	[ "GENE-Y", "CHEMICAL" ]
antibiotics is a GROUP, methotrexate is a DRUG, pyrimethamine is a DRUG, folic acid is a DRUG, vitamin B12 is a DRUG, Colchicine is a DRUG, para - aminosalicylic acid is a DRUG, alcohol is a DRUG, vitamin B12 is a DRUG	Cyanocobalamin_ddi_task0	Sentence: Persons taking most antibiotics, methotrexate and pyrimethamine invalidate folic acid and vitamin B12 diagnostic blood assays. Colchicine para-aminosalicylic acid and heavy alcohol intake for longer than 2 weeks may produce malabsorption of vitamin B12. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GROUP, DRUG	[ "O", "O", "O", "B-GROUP", "O", "B-DRUG", "O", "B-DRUG", "O", "B-DRUG", "I-DRUG", "O", "B-DRUG", "I-DRUG", "O", "O", "O", "O", "B-DRUG", "B-DRUG", "I-DRUG", "I-DRUG", "I-DRUG", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "I-DRUG", "O" ]	Persons taking most antibiotics, methotrexate and pyrimethamine invalidate folic acid and vitamin B12 diagnostic blood assays. Colchicine para-aminosalicylic acid and heavy alcohol intake for longer than 2 weeks may produce malabsorption of vitamin B12.	[ "Persons", "taking", "most", "antibiotics", ",", "methotrexate", "and", "pyrimethamine", "invalidate", "folic", "acid", "and", "vitamin", "B12", "diagnostic", "blood", "assays", ".", "Colchicine", "para", "-", "aminosalicylic", "acid", "and", "heavy", "alcohol", "intake", "for", "longer", "than", "2", "weeks", "may", "produce", "malabsorption", "of", "vitamin", "B12", "." ]	[ "DRUG", "GROUP" ]
antibiotics is a GROUP, methotrexate is a DRUG, pyrimethamine is a DRUG, folic acid is a DRUG, vitamin B12 is a DRUG, Colchicine is a DRUG, para - aminosalicylic acid is a DRUG, alcohol is a DRUG, vitamin B12 is a DRUG	Cyanocobalamin_ddi_task1	Sentence: Persons taking most antibiotics, methotrexate and pyrimethamine invalidate folic acid and vitamin B12 diagnostic blood assays. Colchicine para-aminosalicylic acid and heavy alcohol intake for longer than 2 weeks may produce malabsorption of vitamin B12. Instructions: please typing these entity words according to sentence: antibiotics, methotrexate, pyrimethamine, folic acid, vitamin B12, Colchicine, para - aminosalicylic acid, alcohol, vitamin B12 Options: GROUP, DRUG	[ "O", "O", "O", "B-GROUP", "O", "B-DRUG", "O", "B-DRUG", "O", "B-DRUG", "I-DRUG", "O", "B-DRUG", "I-DRUG", "O", "O", "O", "O", "B-DRUG", "B-DRUG", "I-DRUG", "I-DRUG", "I-DRUG", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "I-DRUG", "O" ]	Persons taking most antibiotics, methotrexate and pyrimethamine invalidate folic acid and vitamin B12 diagnostic blood assays. Colchicine para-aminosalicylic acid and heavy alcohol intake for longer than 2 weeks may produce malabsorption of vitamin B12.	[ "Persons", "taking", "most", "antibiotics", ",", "methotrexate", "and", "pyrimethamine", "invalidate", "folic", "acid", "and", "vitamin", "B12", "diagnostic", "blood", "assays", ".", "Colchicine", "para", "-", "aminosalicylic", "acid", "and", "heavy", "alcohol", "intake", "for", "longer", "than", "2", "weeks", "may", "produce", "malabsorption", "of", "vitamin", "B12", "." ]	[ "DRUG", "GROUP" ]
antibiotics, methotrexate, pyrimethamine, folic acid, vitamin B12, Colchicine, para - aminosalicylic acid, alcohol, vitamin B12	Cyanocobalamin_ddi_task2	Sentence: Persons taking most antibiotics, methotrexate and pyrimethamine invalidate folic acid and vitamin B12 diagnostic blood assays. Colchicine para-aminosalicylic acid and heavy alcohol intake for longer than 2 weeks may produce malabsorption of vitamin B12. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-GROUP", "O", "B-DRUG", "O", "B-DRUG", "O", "B-DRUG", "I-DRUG", "O", "B-DRUG", "I-DRUG", "O", "O", "O", "O", "B-DRUG", "B-DRUG", "I-DRUG", "I-DRUG", "I-DRUG", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "I-DRUG", "O" ]	Persons taking most antibiotics, methotrexate and pyrimethamine invalidate folic acid and vitamin B12 diagnostic blood assays. Colchicine para-aminosalicylic acid and heavy alcohol intake for longer than 2 weeks may produce malabsorption of vitamin B12.	[ "Persons", "taking", "most", "antibiotics", ",", "methotrexate", "and", "pyrimethamine", "invalidate", "folic", "acid", "and", "vitamin", "B12", "diagnostic", "blood", "assays", ".", "Colchicine", "para", "-", "aminosalicylic", "acid", "and", "heavy", "alcohol", "intake", "for", "longer", "than", "2", "weeks", "may", "produce", "malabsorption", "of", "vitamin", "B12", "." ]	[ "DRUG", "GROUP" ]
Duodenopankreatektomie is an umlsterm, Duodenopankreatektomie is an umlsterm, Patienten is an umlsterm, Morbiditaet is an umlsterm, Prognose is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Tumornachsorge is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Operationsmethode is an umlsterm, Komplikationen is an umlsterm, Standardoperation is an umlsterm, Patienten is an umlsterm, Operationsmethode is an umlsterm, Prognose is an umlsterm	DerChirurg.70681262.ger.abstr_task0	Sentence: Zusammenfassung . Anhand einer Studie mit prospektiv erhobenen Daten wurde die Wertigkeit der pyloruserhaltenden partiellen Duodenopankreatektomie ( PPPD ) im Vergleich zur partiellen Duodenopankreatektomie nach Whipple ( PD ) bei Patienten mit einem duktalen Pankreascarcinom bzgl. postoperativer Morbiditaet , Letalitaet und Prognose verglichen . Von Mai 1990 bis April 1995 gingen 130 Patienten in die Studie ein , wobei 61 eine PD bzw. 69 Patienten eine PPPD erhielten . Alle Patienten wurden in 6monatigen Abstaenden im Rahmen der Tumornachsorge nachuntersucht . Das mediane Nachuntersuchungsintervall lag bei den Patienten bei 36 Monaten ; die Ueberlebenskurven wurden nach Kaplan-Meier errechnet . Es zeigte sich , dass die PPPD bei Patienten mit duktalem Pankreaskopfcarcinom ohne Infiltration des Duodenums die technisch einfachere , blutsparendere , schnellere Operationsmethode ist , die zu keinen erhoehten perioperativen Komplikationen fuehrt . Magenentleerungsstoerungen waren allenfalls temporaer und unterschieden sich nicht signifikant von der Standardoperation nach Whipple ( PD ) . Die mediane Ueberlebenszeit der Patienten in der PD-Gruppe lag in bezug auf alle Stadien bei 10,8 Monaten , in der PPPD-Gruppe bei 21 Monaten . Dieser an sich signifikante Unterschied erklaert sich jedoch aus der etwas unterschiedlichen Verteilung der UICC-Stadien in beiden Behandlungsgruppen . Betrachtet man das haeufigste Stadium ( UICC-Stadium III ) , so konnte kein Unterschied in den medianen Ueberlebenszeiten zwischen den Gruppen festgestellt werden : Sie liegen bei 10,1 bzw. 11,2 Monaten . Die PPPD stellt somit eine radikale Operationsmethode dar , die die Prognose der Erkrankung nicht verschlechtert . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	Zusammenfassung . Anhand einer Studie mit prospektiv erhobenen Daten wurde die Wertigkeit der pyloruserhaltenden partiellen Duodenopankreatektomie ( PPPD ) im Vergleich zur partiellen Duodenopankreatektomie nach Whipple ( PD ) bei Patienten mit einem duktalen Pankreascarcinom bzgl. postoperativer Morbiditaet , Letalitaet und Prognose verglichen . Von Mai 1990 bis April 1995 gingen 130 Patienten in die Studie ein , wobei 61 eine PD bzw. 69 Patienten eine PPPD erhielten . Alle Patienten wurden in 6monatigen Abstaenden im Rahmen der Tumornachsorge nachuntersucht . Das mediane Nachuntersuchungsintervall lag bei den Patienten bei 36 Monaten ; die Ueberlebenskurven wurden nach Kaplan-Meier errechnet . Es zeigte sich , dass die PPPD bei Patienten mit duktalem Pankreaskopfcarcinom ohne Infiltration des Duodenums die technisch einfachere , blutsparendere , schnellere Operationsmethode ist , die zu keinen erhoehten perioperativen Komplikationen fuehrt . Magenentleerungsstoerungen waren allenfalls temporaer und unterschieden sich nicht signifikant von der Standardoperation nach Whipple ( PD ) . Die mediane Ueberlebenszeit der Patienten in der PD-Gruppe lag in bezug auf alle Stadien bei 10,8 Monaten , in der PPPD-Gruppe bei 21 Monaten . Dieser an sich signifikante Unterschied erklaert sich jedoch aus der etwas unterschiedlichen Verteilung der UICC-Stadien in beiden Behandlungsgruppen . Betrachtet man das haeufigste Stadium ( UICC-Stadium III ) , so konnte kein Unterschied in den medianen Ueberlebenszeiten zwischen den Gruppen festgestellt werden : Sie liegen bei 10,1 bzw. 11,2 Monaten . Die PPPD stellt somit eine radikale Operationsmethode dar , die die Prognose der Erkrankung nicht verschlechtert .	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Duodenopankreatektomie is an umlsterm, Duodenopankreatektomie is an umlsterm, Patienten is an umlsterm, Morbiditaet is an umlsterm, Prognose is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Tumornachsorge is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Operationsmethode is an umlsterm, Komplikationen is an umlsterm, Standardoperation is an umlsterm, Patienten is an umlsterm, Operationsmethode is an umlsterm, Prognose is an umlsterm	DerChirurg.70681262.ger.abstr_task1	Sentence: Zusammenfassung . Anhand einer Studie mit prospektiv erhobenen Daten wurde die Wertigkeit der pyloruserhaltenden partiellen Duodenopankreatektomie ( PPPD ) im Vergleich zur partiellen Duodenopankreatektomie nach Whipple ( PD ) bei Patienten mit einem duktalen Pankreascarcinom bzgl. postoperativer Morbiditaet , Letalitaet und Prognose verglichen . Von Mai 1990 bis April 1995 gingen 130 Patienten in die Studie ein , wobei 61 eine PD bzw. 69 Patienten eine PPPD erhielten . Alle Patienten wurden in 6monatigen Abstaenden im Rahmen der Tumornachsorge nachuntersucht . Das mediane Nachuntersuchungsintervall lag bei den Patienten bei 36 Monaten ; die Ueberlebenskurven wurden nach Kaplan-Meier errechnet . Es zeigte sich , dass die PPPD bei Patienten mit duktalem Pankreaskopfcarcinom ohne Infiltration des Duodenums die technisch einfachere , blutsparendere , schnellere Operationsmethode ist , die zu keinen erhoehten perioperativen Komplikationen fuehrt . Magenentleerungsstoerungen waren allenfalls temporaer und unterschieden sich nicht signifikant von der Standardoperation nach Whipple ( PD ) . Die mediane Ueberlebenszeit der Patienten in der PD-Gruppe lag in bezug auf alle Stadien bei 10,8 Monaten , in der PPPD-Gruppe bei 21 Monaten . Dieser an sich signifikante Unterschied erklaert sich jedoch aus der etwas unterschiedlichen Verteilung der UICC-Stadien in beiden Behandlungsgruppen . Betrachtet man das haeufigste Stadium ( UICC-Stadium III ) , so konnte kein Unterschied in den medianen Ueberlebenszeiten zwischen den Gruppen festgestellt werden : Sie liegen bei 10,1 bzw. 11,2 Monaten . Die PPPD stellt somit eine radikale Operationsmethode dar , die die Prognose der Erkrankung nicht verschlechtert . Instructions: please typing these entity words according to sentence: Duodenopankreatektomie, Duodenopankreatektomie, Patienten, Morbiditaet, Prognose, Patienten, Patienten, Patienten, Tumornachsorge, Patienten, Patienten, Operationsmethode, Komplikationen, Standardoperation, Patienten, Operationsmethode, Prognose Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	Zusammenfassung . Anhand einer Studie mit prospektiv erhobenen Daten wurde die Wertigkeit der pyloruserhaltenden partiellen Duodenopankreatektomie ( PPPD ) im Vergleich zur partiellen Duodenopankreatektomie nach Whipple ( PD ) bei Patienten mit einem duktalen Pankreascarcinom bzgl. postoperativer Morbiditaet , Letalitaet und Prognose verglichen . Von Mai 1990 bis April 1995 gingen 130 Patienten in die Studie ein , wobei 61 eine PD bzw. 69 Patienten eine PPPD erhielten . Alle Patienten wurden in 6monatigen Abstaenden im Rahmen der Tumornachsorge nachuntersucht . Das mediane Nachuntersuchungsintervall lag bei den Patienten bei 36 Monaten ; die Ueberlebenskurven wurden nach Kaplan-Meier errechnet . Es zeigte sich , dass die PPPD bei Patienten mit duktalem Pankreaskopfcarcinom ohne Infiltration des Duodenums die technisch einfachere , blutsparendere , schnellere Operationsmethode ist , die zu keinen erhoehten perioperativen Komplikationen fuehrt . Magenentleerungsstoerungen waren allenfalls temporaer und unterschieden sich nicht signifikant von der Standardoperation nach Whipple ( PD ) . Die mediane Ueberlebenszeit der Patienten in der PD-Gruppe lag in bezug auf alle Stadien bei 10,8 Monaten , in der PPPD-Gruppe bei 21 Monaten . Dieser an sich signifikante Unterschied erklaert sich jedoch aus der etwas unterschiedlichen Verteilung der UICC-Stadien in beiden Behandlungsgruppen . Betrachtet man das haeufigste Stadium ( UICC-Stadium III ) , so konnte kein Unterschied in den medianen Ueberlebenszeiten zwischen den Gruppen festgestellt werden : Sie liegen bei 10,1 bzw. 11,2 Monaten . Die PPPD stellt somit eine radikale Operationsmethode dar , die die Prognose der Erkrankung nicht verschlechtert .	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Duodenopankreatektomie, Duodenopankreatektomie, Patienten, Morbiditaet, Prognose, Patienten, Patienten, Patienten, Tumornachsorge, Patienten, Patienten, Operationsmethode, Komplikationen, Standardoperation, Patienten, Operationsmethode, Prognose	DerChirurg.70681262.ger.abstr_task2	Sentence: Zusammenfassung . Anhand einer Studie mit prospektiv erhobenen Daten wurde die Wertigkeit der pyloruserhaltenden partiellen Duodenopankreatektomie ( PPPD ) im Vergleich zur partiellen Duodenopankreatektomie nach Whipple ( PD ) bei Patienten mit einem duktalen Pankreascarcinom bzgl. postoperativer Morbiditaet , Letalitaet und Prognose verglichen . Von Mai 1990 bis April 1995 gingen 130 Patienten in die Studie ein , wobei 61 eine PD bzw. 69 Patienten eine PPPD erhielten . Alle Patienten wurden in 6monatigen Abstaenden im Rahmen der Tumornachsorge nachuntersucht . Das mediane Nachuntersuchungsintervall lag bei den Patienten bei 36 Monaten ; die Ueberlebenskurven wurden nach Kaplan-Meier errechnet . Es zeigte sich , dass die PPPD bei Patienten mit duktalem Pankreaskopfcarcinom ohne Infiltration des Duodenums die technisch einfachere , blutsparendere , schnellere Operationsmethode ist , die zu keinen erhoehten perioperativen Komplikationen fuehrt . Magenentleerungsstoerungen waren allenfalls temporaer und unterschieden sich nicht signifikant von der Standardoperation nach Whipple ( PD ) . Die mediane Ueberlebenszeit der Patienten in der PD-Gruppe lag in bezug auf alle Stadien bei 10,8 Monaten , in der PPPD-Gruppe bei 21 Monaten . Dieser an sich signifikante Unterschied erklaert sich jedoch aus der etwas unterschiedlichen Verteilung der UICC-Stadien in beiden Behandlungsgruppen . Betrachtet man das haeufigste Stadium ( UICC-Stadium III ) , so konnte kein Unterschied in den medianen Ueberlebenszeiten zwischen den Gruppen festgestellt werden : Sie liegen bei 10,1 bzw. 11,2 Monaten . Die PPPD stellt somit eine radikale Operationsmethode dar , die die Prognose der Erkrankung nicht verschlechtert . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	Zusammenfassung . Anhand einer Studie mit prospektiv erhobenen Daten wurde die Wertigkeit der pyloruserhaltenden partiellen Duodenopankreatektomie ( PPPD ) im Vergleich zur partiellen Duodenopankreatektomie nach Whipple ( PD ) bei Patienten mit einem duktalen Pankreascarcinom bzgl. postoperativer Morbiditaet , Letalitaet und Prognose verglichen . Von Mai 1990 bis April 1995 gingen 130 Patienten in die Studie ein , wobei 61 eine PD bzw. 69 Patienten eine PPPD erhielten . Alle Patienten wurden in 6monatigen Abstaenden im Rahmen der Tumornachsorge nachuntersucht . Das mediane Nachuntersuchungsintervall lag bei den Patienten bei 36 Monaten ; die Ueberlebenskurven wurden nach Kaplan-Meier errechnet . Es zeigte sich , dass die PPPD bei Patienten mit duktalem Pankreaskopfcarcinom ohne Infiltration des Duodenums die technisch einfachere , blutsparendere , schnellere Operationsmethode ist , die zu keinen erhoehten perioperativen Komplikationen fuehrt . Magenentleerungsstoerungen waren allenfalls temporaer und unterschieden sich nicht signifikant von der Standardoperation nach Whipple ( PD ) . Die mediane Ueberlebenszeit der Patienten in der PD-Gruppe lag in bezug auf alle Stadien bei 10,8 Monaten , in der PPPD-Gruppe bei 21 Monaten . Dieser an sich signifikante Unterschied erklaert sich jedoch aus der etwas unterschiedlichen Verteilung der UICC-Stadien in beiden Behandlungsgruppen . Betrachtet man das haeufigste Stadium ( UICC-Stadium III ) , so konnte kein Unterschied in den medianen Ueberlebenszeiten zwischen den Gruppen festgestellt werden : Sie liegen bei 10,1 bzw. 11,2 Monaten . Die PPPD stellt somit eine radikale Operationsmethode dar , die die Prognose der Erkrankung nicht verschlechtert .	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metastasized melanoma is a DISEASE, metastatic melanoma is a DISEASE, alopecia is a ADVERSE, peripheral neuropathy is a ADVERSE, melanoma is a DISEASE	example-375_task0	Sentence: Adjuvant treatment with vindesine in comparison to observation alone in patients with metastasized melanoma after complete metastasectomy: a randomized multicenter trial of the German Dermatologic Cooperative Oncology Group. To evaluate the efficacy and safety of vindesine in patients with metastatic melanoma after complete metastasectomy. One hundred and forty-two patients with metastatic spread to regional sites, lymph nodes, and distant sites after complete metastasectomy were randomized to receive either treatment with vindesine for 2 years or observation alone. Vindesine 3 mg/m intravenously was administered biweekly for the first 26 weeks following 3-week intervals for an additional 26 weeks and thereafter every 4 weeks for 52 weeks. One hundred and thirty-nine patients were eligible for intent-to-treat analysis. Median follow-up time was 46 months. Median recurrence free survival was 7.9 months in the vindesine group and 7.6 months in the observational group (P=0.40). Three-year overall survival rate was 54.9% (37 patients) for patients receiving vindesine in comparison to 43.6% (31 patients) in the observation arm (P=0.07). No grade IV toxicity was observed. The two major side effects in the vindesine group were alopecia and peripheral neuropathy. Ten patients went off treatment because of grade III toxicity. Adjuvant treatment with vindesine did not significantly prolong disease free or overall survival in high-risk melanoma patients. Thus, this randomized trial did not confirm earlier reports of beneficial effects of adjuvant vindesine and can therefore not be recommended. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: ADVERSE, DISEASE	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DISEASE", "I-DISEASE", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DISEASE", "I-DISEASE", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-ADVERSE", "O", "B-ADVERSE", "I-ADVERSE", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DISEASE", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Adjuvant treatment with vindesine in comparison to observation alone in patients with metastasized melanoma after complete metastasectomy: a randomized multicenter trial of the German Dermatologic Cooperative Oncology Group. To evaluate the efficacy and safety of vindesine in patients with metastatic melanoma after complete metastasectomy. One hundred and forty-two patients with metastatic spread to regional sites, lymph nodes, and distant sites after complete metastasectomy were randomized to receive either treatment with vindesine for 2 years or observation alone. Vindesine 3 mg/m intravenously was administered biweekly for the first 26 weeks following 3-week intervals for an additional 26 weeks and thereafter every 4 weeks for 52 weeks. One hundred and thirty-nine patients were eligible for intent-to-treat analysis. Median follow-up time was 46 months. Median recurrence free survival was 7.9 months in the vindesine group and 7.6 months in the observational group (P=0.40). Three-year overall survival rate was 54.9% (37 patients) for patients receiving vindesine in comparison to 43.6% (31 patients) in the observation arm (P=0.07). No grade IV toxicity was observed. The two major side effects in the vindesine group were alopecia and peripheral neuropathy. Ten patients went off treatment because of grade III toxicity. Adjuvant treatment with vindesine did not significantly prolong disease free or overall survival in high-risk melanoma patients. Thus, this randomized trial did not confirm earlier reports of beneficial effects of adjuvant vindesine and can therefore not be recommended.	[ "Adjuvant", "treatment", "with", "vindesine", "in", "comparison", "to", "observation", "alone", "in", "patients", "with", "metastasized", "melanoma", "after", "complete", "metastasectomy", ":", "a", "randomized", "multicenter", "trial", "of", "the", "German", "Dermatologic", "Cooperative", "Oncology", "Group", ".", " ", "To", "evaluate", "the", "efficacy", "and", "safety", "of", "vindesine", "in", "patients", "with", "metastatic", "melanoma", "after", "complete", "metastasectomy", ".", "One", "hundred", "and", "forty", "-", "two", "patients", "with", "metastatic", "spread", "to", "regional", "sites", ",", "lymph", "nodes", ",", "and", "distant", "sites", "after", "complete", "metastasectomy", "were", "randomized", "to", "receive", "either", "treatment", "with", "vindesine", "for", "2", "years", "or", "observation", "alone", ".", "Vindesine", "3", "mg", "/", "m", "intravenously", "was", "administered", "biweekly", "for", "the", "first", "26", "weeks", "following", "3-week", "intervals", "for", "an", "additional", "26", "weeks", "and", "thereafter", "every", "4", "weeks", "for", "52", "weeks", ".", "One", "hundred", "and", "thirty", "-", "nine", "patients", "were", "eligible", "for", "intent", "-", "to", "-", "treat", "analysis", ".", "Median", "follow", "-", "up", "time", "was", "46", "months", ".", "Median", "recurrence", "free", "survival", "was", "7.9", "months", "in", "the", "vindesine", "group", "and", "7.6", "months", "in", "the", "observational", "group", "(", "P=0.40", ")", ".", "Three", "-", "year", "overall", "survival", "rate", "was", "54.9", "%", "(", "37", "patients", ")", "for", "patients", "receiving", "vindesine", "in", "comparison", "to", "43.6", "%", "(", "31", "patients", ")", "in", "the", "observation", "arm", "(", "P=0.07", ")", ".", "No", "grade", "IV", "toxicity", "was", "observed", ".", "The", "two", "major", "side", "effects", "in", "the", "vindesine", "group", "were", "alopecia", "and", "peripheral", "neuropathy", ".", "Ten", "patients", "went", "off", "treatment", "because", "of", "grade", "III", "toxicity", ".", "Adjuvant", "treatment", "with", "vindesine", "did", "not", "significantly", "prolong", "disease", "free", "or", "overall", "survival", "in", "high", "-", "risk", "melanoma", "patients", ".", "Thus", ",", "this", "randomized", "trial", "did", "not", "confirm", "earlier", "reports", "of", "beneficial", "effects", "of", "adjuvant", "vindesine", "and", "can", "therefore", "not", "be", "recommended", "." ]	[ "DISEASE", "ADVERSE" ]
metastasized melanoma is a DISEASE, metastatic melanoma is a DISEASE, alopecia is a ADVERSE, peripheral neuropathy is a ADVERSE, melanoma is a DISEASE	example-375_task1	Sentence: Adjuvant treatment with vindesine in comparison to observation alone in patients with metastasized melanoma after complete metastasectomy: a randomized multicenter trial of the German Dermatologic Cooperative Oncology Group. To evaluate the efficacy and safety of vindesine in patients with metastatic melanoma after complete metastasectomy. One hundred and forty-two patients with metastatic spread to regional sites, lymph nodes, and distant sites after complete metastasectomy were randomized to receive either treatment with vindesine for 2 years or observation alone. Vindesine 3 mg/m intravenously was administered biweekly for the first 26 weeks following 3-week intervals for an additional 26 weeks and thereafter every 4 weeks for 52 weeks. One hundred and thirty-nine patients were eligible for intent-to-treat analysis. Median follow-up time was 46 months. Median recurrence free survival was 7.9 months in the vindesine group and 7.6 months in the observational group (P=0.40). Three-year overall survival rate was 54.9% (37 patients) for patients receiving vindesine in comparison to 43.6% (31 patients) in the observation arm (P=0.07). No grade IV toxicity was observed. The two major side effects in the vindesine group were alopecia and peripheral neuropathy. Ten patients went off treatment because of grade III toxicity. Adjuvant treatment with vindesine did not significantly prolong disease free or overall survival in high-risk melanoma patients. Thus, this randomized trial did not confirm earlier reports of beneficial effects of adjuvant vindesine and can therefore not be recommended. Instructions: please typing these entity words according to sentence: metastasized melanoma, metastatic melanoma, alopecia, peripheral neuropathy, melanoma Options: ADVERSE, DISEASE	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DISEASE", "I-DISEASE", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DISEASE", "I-DISEASE", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-ADVERSE", "O", "B-ADVERSE", "I-ADVERSE", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DISEASE", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Adjuvant treatment with vindesine in comparison to observation alone in patients with metastasized melanoma after complete metastasectomy: a randomized multicenter trial of the German Dermatologic Cooperative Oncology Group. To evaluate the efficacy and safety of vindesine in patients with metastatic melanoma after complete metastasectomy. One hundred and forty-two patients with metastatic spread to regional sites, lymph nodes, and distant sites after complete metastasectomy were randomized to receive either treatment with vindesine for 2 years or observation alone. Vindesine 3 mg/m intravenously was administered biweekly for the first 26 weeks following 3-week intervals for an additional 26 weeks and thereafter every 4 weeks for 52 weeks. One hundred and thirty-nine patients were eligible for intent-to-treat analysis. Median follow-up time was 46 months. Median recurrence free survival was 7.9 months in the vindesine group and 7.6 months in the observational group (P=0.40). Three-year overall survival rate was 54.9% (37 patients) for patients receiving vindesine in comparison to 43.6% (31 patients) in the observation arm (P=0.07). No grade IV toxicity was observed. The two major side effects in the vindesine group were alopecia and peripheral neuropathy. Ten patients went off treatment because of grade III toxicity. Adjuvant treatment with vindesine did not significantly prolong disease free or overall survival in high-risk melanoma patients. Thus, this randomized trial did not confirm earlier reports of beneficial effects of adjuvant vindesine and can therefore not be recommended.	[ "Adjuvant", "treatment", "with", "vindesine", "in", "comparison", "to", "observation", "alone", "in", "patients", "with", "metastasized", "melanoma", "after", "complete", "metastasectomy", ":", "a", "randomized", "multicenter", "trial", "of", "the", "German", "Dermatologic", "Cooperative", "Oncology", "Group", ".", " ", "To", "evaluate", "the", "efficacy", "and", "safety", "of", "vindesine", "in", "patients", "with", "metastatic", "melanoma", "after", "complete", "metastasectomy", ".", "One", "hundred", "and", "forty", "-", "two", "patients", "with", "metastatic", "spread", "to", "regional", "sites", ",", "lymph", "nodes", ",", "and", "distant", "sites", "after", "complete", "metastasectomy", "were", "randomized", "to", "receive", "either", "treatment", "with", "vindesine", "for", "2", "years", "or", "observation", "alone", ".", "Vindesine", "3", "mg", "/", "m", "intravenously", "was", "administered", "biweekly", "for", "the", "first", "26", "weeks", "following", "3-week", "intervals", "for", "an", "additional", "26", "weeks", "and", "thereafter", "every", "4", "weeks", "for", "52", "weeks", ".", "One", "hundred", "and", "thirty", "-", "nine", "patients", "were", "eligible", "for", "intent", "-", "to", "-", "treat", "analysis", ".", "Median", "follow", "-", "up", "time", "was", "46", "months", ".", "Median", "recurrence", "free", "survival", "was", "7.9", "months", "in", "the", "vindesine", "group", "and", "7.6", "months", "in", "the", "observational", "group", "(", "P=0.40", ")", ".", "Three", "-", "year", "overall", "survival", "rate", "was", "54.9", "%", "(", "37", "patients", ")", "for", "patients", "receiving", "vindesine", "in", "comparison", "to", "43.6", "%", "(", "31", "patients", ")", "in", "the", "observation", "arm", "(", "P=0.07", ")", ".", "No", "grade", "IV", "toxicity", "was", "observed", ".", "The", "two", "major", "side", "effects", "in", "the", "vindesine", "group", "were", "alopecia", "and", "peripheral", "neuropathy", ".", "Ten", "patients", "went", "off", "treatment", "because", "of", "grade", "III", "toxicity", ".", "Adjuvant", "treatment", "with", "vindesine", "did", "not", "significantly", "prolong", "disease", "free", "or", "overall", "survival", "in", "high", "-", "risk", "melanoma", "patients", ".", "Thus", ",", "this", "randomized", "trial", "did", "not", "confirm", "earlier", "reports", "of", "beneficial", "effects", "of", "adjuvant", "vindesine", "and", "can", "therefore", "not", "be", "recommended", "." ]	[ "DISEASE", "ADVERSE" ]
metastasized melanoma, metastatic melanoma, alopecia, peripheral neuropathy, melanoma	example-375_task2	Sentence: Adjuvant treatment with vindesine in comparison to observation alone in patients with metastasized melanoma after complete metastasectomy: a randomized multicenter trial of the German Dermatologic Cooperative Oncology Group. To evaluate the efficacy and safety of vindesine in patients with metastatic melanoma after complete metastasectomy. One hundred and forty-two patients with metastatic spread to regional sites, lymph nodes, and distant sites after complete metastasectomy were randomized to receive either treatment with vindesine for 2 years or observation alone. Vindesine 3 mg/m intravenously was administered biweekly for the first 26 weeks following 3-week intervals for an additional 26 weeks and thereafter every 4 weeks for 52 weeks. One hundred and thirty-nine patients were eligible for intent-to-treat analysis. Median follow-up time was 46 months. Median recurrence free survival was 7.9 months in the vindesine group and 7.6 months in the observational group (P=0.40). Three-year overall survival rate was 54.9% (37 patients) for patients receiving vindesine in comparison to 43.6% (31 patients) in the observation arm (P=0.07). No grade IV toxicity was observed. The two major side effects in the vindesine group were alopecia and peripheral neuropathy. Ten patients went off treatment because of grade III toxicity. Adjuvant treatment with vindesine did not significantly prolong disease free or overall survival in high-risk melanoma patients. Thus, this randomized trial did not confirm earlier reports of beneficial effects of adjuvant vindesine and can therefore not be recommended. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DISEASE", "I-DISEASE", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DISEASE", "I-DISEASE", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-ADVERSE", "O", "B-ADVERSE", "I-ADVERSE", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DISEASE", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Adjuvant treatment with vindesine in comparison to observation alone in patients with metastasized melanoma after complete metastasectomy: a randomized multicenter trial of the German Dermatologic Cooperative Oncology Group. To evaluate the efficacy and safety of vindesine in patients with metastatic melanoma after complete metastasectomy. One hundred and forty-two patients with metastatic spread to regional sites, lymph nodes, and distant sites after complete metastasectomy were randomized to receive either treatment with vindesine for 2 years or observation alone. Vindesine 3 mg/m intravenously was administered biweekly for the first 26 weeks following 3-week intervals for an additional 26 weeks and thereafter every 4 weeks for 52 weeks. One hundred and thirty-nine patients were eligible for intent-to-treat analysis. Median follow-up time was 46 months. Median recurrence free survival was 7.9 months in the vindesine group and 7.6 months in the observational group (P=0.40). Three-year overall survival rate was 54.9% (37 patients) for patients receiving vindesine in comparison to 43.6% (31 patients) in the observation arm (P=0.07). No grade IV toxicity was observed. The two major side effects in the vindesine group were alopecia and peripheral neuropathy. Ten patients went off treatment because of grade III toxicity. Adjuvant treatment with vindesine did not significantly prolong disease free or overall survival in high-risk melanoma patients. Thus, this randomized trial did not confirm earlier reports of beneficial effects of adjuvant vindesine and can therefore not be recommended.	[ "Adjuvant", "treatment", "with", "vindesine", "in", "comparison", "to", "observation", "alone", "in", "patients", "with", "metastasized", "melanoma", "after", "complete", "metastasectomy", ":", "a", "randomized", "multicenter", "trial", "of", "the", "German", "Dermatologic", "Cooperative", "Oncology", "Group", ".", " ", "To", "evaluate", "the", "efficacy", "and", "safety", "of", "vindesine", "in", "patients", "with", "metastatic", "melanoma", "after", "complete", "metastasectomy", ".", "One", "hundred", "and", "forty", "-", "two", "patients", "with", "metastatic", "spread", "to", "regional", "sites", ",", "lymph", "nodes", ",", "and", "distant", "sites", "after", "complete", "metastasectomy", "were", "randomized", "to", "receive", "either", "treatment", "with", "vindesine", "for", "2", "years", "or", "observation", "alone", ".", "Vindesine", "3", "mg", "/", "m", "intravenously", "was", "administered", "biweekly", "for", "the", "first", "26", "weeks", "following", "3-week", "intervals", "for", "an", "additional", "26", "weeks", "and", "thereafter", "every", "4", "weeks", "for", "52", "weeks", ".", "One", "hundred", "and", "thirty", "-", "nine", "patients", "were", "eligible", "for", "intent", "-", "to", "-", "treat", "analysis", ".", "Median", "follow", "-", "up", "time", "was", "46", "months", ".", "Median", "recurrence", "free", "survival", "was", "7.9", "months", "in", "the", "vindesine", "group", "and", "7.6", "months", "in", "the", "observational", "group", "(", "P=0.40", ")", ".", "Three", "-", "year", "overall", "survival", "rate", "was", "54.9", "%", "(", "37", "patients", ")", "for", "patients", "receiving", "vindesine", "in", "comparison", "to", "43.6", "%", "(", "31", "patients", ")", "in", "the", "observation", "arm", "(", "P=0.07", ")", ".", "No", "grade", "IV", "toxicity", "was", "observed", ".", "The", "two", "major", "side", "effects", "in", "the", "vindesine", "group", "were", "alopecia", "and", "peripheral", "neuropathy", ".", "Ten", "patients", "went", "off", "treatment", "because", "of", "grade", "III", "toxicity", ".", "Adjuvant", "treatment", "with", "vindesine", "did", "not", "significantly", "prolong", "disease", "free", "or", "overall", "survival", "in", "high", "-", "risk", "melanoma", "patients", ".", "Thus", ",", "this", "randomized", "trial", "did", "not", "confirm", "earlier", "reports", "of", "beneficial", "effects", "of", "adjuvant", "vindesine", "and", "can", "therefore", "not", "be", "recommended", "." ]	[ "DISEASE", "ADVERSE" ]
molsidomine is a compound, nitric oxide is a compound, HIF-1alpha is a protein	DS.d1141_task0	Sentence: This study was designed to determine the effect of molsidomine (MO), a precursor of nitric oxide (NO) donor, on hypoxia inducible factor alpha (HIF-1alpha) and Sonic hedgehog (Shh) levels considered to be involved in the development of testes ischemia/reperfusion (I-R) injury. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	This study was designed to determine the effect of molsidomine (MO), a precursor of nitric oxide (NO) donor, on hypoxia inducible factor alpha (HIF-1alpha) and Sonic hedgehog (Shh) levels considered to be involved in the development of testes ischemia/reperfusion (I-R) injury.	[ "This", "study", "was", "designed", "to", "determine", "the", "effect", "of", "molsidomine", "(", "MO", ")", ",", "a", "precursor", "of", "nitric", "oxide", "(", "NO", ")", "donor", ",", "on", "hypoxia", "inducible", "factor", "alpha", "(", "HIF-1alpha", ")", "and", "Sonic", "hedgehog", "(", "Shh", ")", "levels", "considered", "to", "be", "involved", "in", "the", "development", "of", "testes", "ischemia", "/", "reperfusion", "(", "I", "-", "R", ")", "injury", "." ]	[ "compound", "protein" ]
molsidomine is a compound, nitric oxide is a compound, HIF-1alpha is a protein	DS.d1141_task1	Sentence: This study was designed to determine the effect of molsidomine (MO), a precursor of nitric oxide (NO) donor, on hypoxia inducible factor alpha (HIF-1alpha) and Sonic hedgehog (Shh) levels considered to be involved in the development of testes ischemia/reperfusion (I-R) injury. Instructions: please typing these entity words according to sentence: molsidomine, nitric oxide, HIF-1alpha Options: compound, protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	This study was designed to determine the effect of molsidomine (MO), a precursor of nitric oxide (NO) donor, on hypoxia inducible factor alpha (HIF-1alpha) and Sonic hedgehog (Shh) levels considered to be involved in the development of testes ischemia/reperfusion (I-R) injury.	[ "This", "study", "was", "designed", "to", "determine", "the", "effect", "of", "molsidomine", "(", "MO", ")", ",", "a", "precursor", "of", "nitric", "oxide", "(", "NO", ")", "donor", ",", "on", "hypoxia", "inducible", "factor", "alpha", "(", "HIF-1alpha", ")", "and", "Sonic", "hedgehog", "(", "Shh", ")", "levels", "considered", "to", "be", "involved", "in", "the", "development", "of", "testes", "ischemia", "/", "reperfusion", "(", "I", "-", "R", ")", "injury", "." ]	[ "compound", "protein" ]
molsidomine, nitric oxide, HIF-1alpha	DS.d1141_task2	Sentence: This study was designed to determine the effect of molsidomine (MO), a precursor of nitric oxide (NO) donor, on hypoxia inducible factor alpha (HIF-1alpha) and Sonic hedgehog (Shh) levels considered to be involved in the development of testes ischemia/reperfusion (I-R) injury. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	This study was designed to determine the effect of molsidomine (MO), a precursor of nitric oxide (NO) donor, on hypoxia inducible factor alpha (HIF-1alpha) and Sonic hedgehog (Shh) levels considered to be involved in the development of testes ischemia/reperfusion (I-R) injury.	[ "This", "study", "was", "designed", "to", "determine", "the", "effect", "of", "molsidomine", "(", "MO", ")", ",", "a", "precursor", "of", "nitric", "oxide", "(", "NO", ")", "donor", ",", "on", "hypoxia", "inducible", "factor", "alpha", "(", "HIF-1alpha", ")", "and", "Sonic", "hedgehog", "(", "Shh", ")", "levels", "considered", "to", "be", "involved", "in", "the", "development", "of", "testes", "ischemia", "/", "reperfusion", "(", "I", "-", "R", ")", "injury", "." ]	[ "compound", "protein" ]
Laryngoscopy is an umlsterm, postoperative is an umlsterm, dysfunction is an umlsterm, temporomandibular joint is an umlsterm, TMJ is an umlsterm, TMJ is an umlsterm, patients is an umlsterm, muscles is an umlsterm, exact is an umlsterm, TMJ is an umlsterm, movements is an umlsterm, method is an umlsterm, TMJ is an umlsterm, movements is an umlsterm, intubation is an umlsterm, electronic is an umlsterm, axiography is an umlsterm, diagnostic is an umlsterm, monitor is an umlsterm, TMJ is an umlsterm, movements is an umlsterm, dentistry is an umlsterm, axis is an umlsterm, plates is an umlsterm, patient is an umlsterm, TMJ is an umlsterm, movement is an umlsterm, mouth is an umlsterm, farward is an umlsterm, incisor is an umlsterm, distance is an umlsterm, plates is an umlsterm, TMJ is an umlsterm, skull - mounted is an umlsterm, plate is an umlsterm, tips is an umlsterm, electronic is an umlsterm, plates is an umlsterm, mandible is an umlsterm, face is an umlsterm, teeth is an umlsterm, face is an umlsterm, patient is an umlsterm, mask is an umlsterm, ventilation is an umlsterm, movement is an umlsterm, laryngoscope is an umlsterm, intubation is an umlsterm, projections is an umlsterm, operating theatre is an umlsterm, endotracheal intubation is an umlsterm, head is an umlsterm, ethics committee is an umlsterm, male is an umlsterm, patients is an umlsterm, ASA is an umlsterm, Mallampati is an umlsterm, limb is an umlsterm, surgery is an umlsterm, intubation is an umlsterm, suxamethonium is an umlsterm, intubation is an umlsterm, vecuronium is an umlsterm, intubation is an umlsterm, suxamethonium is an umlsterm, intubation is an umlsterm, vecuronium is an umlsterm, Intubation is an umlsterm, injection is an umlsterm, findings is an umlsterm, movements is an umlsterm, mandible is an umlsterm, mouth is an umlsterm, dysfunction is an umlsterm, TMJ is an umlsterm, pain is an umlsterm, sensation is an umlsterm, TMJ is an umlsterm, intubations is an umlsterm, TMJ is an umlsterm, movements is an umlsterm, intubation is an umlsterm, method is an umlsterm, TMJ is an umlsterm, movements is an umlsterm, endotracheal intubation is an umlsterm, time is an umlsterm, techniques is an umlsterm, instruments is an umlsterm, intubation is an umlsterm, movements is an umlsterm, endotracheal intubation is an umlsterm	DerAnaesthesist.60450907.eng.abstr_task0	Sentence: Laryngoscopy causes temporary postoperative dysfunction of the temporomandibular joint ( TMJ ) : during iatrogenic TMJ manipulation in anaesthetised patients , the TMJs have lost the protection afforded by the tone of the surrounding muscles . Thus far , the exact type and extent of TMJ movements have not been known . The purpose of this study was to develop a method to visualise and assess TMJ movements during intubation by means of electronic axiography , a diagnostic monitor of TMJ movements used in dentistry : registration of the hinge axis ( HA ) as an equivalent of the condylar paths on extra-oral sagittally mounted , parallel plates . The HA is individually defined in each patient by the pure , rotating TMJ movement during initial mouth opening ( no farward gliding of the condyles , incisor distance up to 10 mm ) . The parallel plates are placed in the TMJ region in the skull-mounted plate bow ; both registration tips ( " drawing " the HA tracings on the electronic plates ) are connected to the mandible by a face bow , paraocclusally fixed to the teeth . The face bow is individually shaped for each patient to allow mask ventilation and free movement of the laryngoscope during intubation . HA tracings are registered and calculated for both sides independently every 24 ms with the SAM/Klett system and presented on sagittal and frontal projections . In the operating theatre , the active mouth-opening traces ( MOT ) are registered first and the passive endotracheal intubation traces ( EIT ) after induction of anaesthesia ( same head position ) . With informed consent and approval by the ethics committee of the Landesaerztekammer Rheinland-Pfalz , 40 male patients ( ASA I , Mallampati I , limb surgery ) were randomly allocated to four groups ( n=10 each ) . OS : Oral intubation , suxamethonium ( 1.5 mg/kg ) ; OV : Oral intubation , vecuronium ( 0.1 mg/kg ) ; NS : Nasal intubation , suxamethonium ( 1.5 mg/kg ) ; and NV : Nasal intubation , vecuronium ( 0.1 mg/kg ) . Intubation was performed 100 s after injection of the relaxant . Pre- and postoperatively ( every 24 h over 3 days , in case of positive findings longer ) recorded were : active movements of the mandible ( maximal mouth opening/max . laterotrusion ) ; dysfunction of the TMJ ; and pain sensation in the TMJ ( Helkimo rating ) . MOTs and EITs were recorded and analysed with the system described and typical EIT patterns were identified : bland , clinically uneventful intubations ( n=7), massive distraction and laterotrusion of the EIT compared to the MOT ( n=24), and blocked or limited TMJ movements resulting in intubation problems ( n=1). With the method presented , TMJ movements could be visualised during endotracheal intubation for the first time . It can be used to assess techniques , routes , and instruments for intubation as well as to evaluate potential traumatising movements during endotracheal intubation . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O" ]	Laryngoscopy causes temporary postoperative dysfunction of the temporomandibular joint ( TMJ ) : during iatrogenic TMJ manipulation in anaesthetised patients , the TMJs have lost the protection afforded by the tone of the surrounding muscles . Thus far , the exact type and extent of TMJ movements have not been known . The purpose of this study was to develop a method to visualise and assess TMJ movements during intubation by means of electronic axiography , a diagnostic monitor of TMJ movements used in dentistry : registration of the hinge axis ( HA ) as an equivalent of the condylar paths on extra-oral sagittally mounted , parallel plates . The HA is individually defined in each patient by the pure , rotating TMJ movement during initial mouth opening ( no farward gliding of the condyles , incisor distance up to 10 mm ) . The parallel plates are placed in the TMJ region in the skull-mounted plate bow ; both registration tips ( " drawing " the HA tracings on the electronic plates ) are connected to the mandible by a face bow , paraocclusally fixed to the teeth . The face bow is individually shaped for each patient to allow mask ventilation and free movement of the laryngoscope during intubation . HA tracings are registered and calculated for both sides independently every 24 ms with the SAM/Klett system and presented on sagittal and frontal projections . In the operating theatre , the active mouth-opening traces ( MOT ) are registered first and the passive endotracheal intubation traces ( EIT ) after induction of anaesthesia ( same head position ) . With informed consent and approval by the ethics committee of the Landesaerztekammer Rheinland-Pfalz , 40 male patients ( ASA I , Mallampati I , limb surgery ) were randomly allocated to four groups ( n=10 each ) . OS : Oral intubation , suxamethonium ( 1.5 mg/kg ) ; OV : Oral intubation , vecuronium ( 0.1 mg/kg ) ; NS : Nasal intubation , suxamethonium ( 1.5 mg/kg ) ; and NV : Nasal intubation , vecuronium ( 0.1 mg/kg ) . Intubation was performed 100 s after injection of the relaxant . Pre- and postoperatively ( every 24 h over 3 days , in case of positive findings longer ) recorded were : active movements of the mandible ( maximal mouth opening/max . laterotrusion ) ; dysfunction of the TMJ ; and pain sensation in the TMJ ( Helkimo rating ) . MOTs and EITs were recorded and analysed with the system described and typical EIT patterns were identified : bland , clinically uneventful intubations ( n=7), massive distraction and laterotrusion of the EIT compared to the MOT ( n=24), and blocked or limited TMJ movements resulting in intubation problems ( n=1). With the method presented , TMJ movements could be visualised during endotracheal intubation for the first time . It can be used to assess techniques , routes , and instruments for intubation as well as to evaluate potential traumatising movements during endotracheal intubation .	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Laryngoscopy is an umlsterm, postoperative is an umlsterm, dysfunction is an umlsterm, temporomandibular joint is an umlsterm, TMJ is an umlsterm, TMJ is an umlsterm, patients is an umlsterm, muscles is an umlsterm, exact is an umlsterm, TMJ is an umlsterm, movements is an umlsterm, method is an umlsterm, TMJ is an umlsterm, movements is an umlsterm, intubation is an umlsterm, electronic is an umlsterm, axiography is an umlsterm, diagnostic is an umlsterm, monitor is an umlsterm, TMJ is an umlsterm, movements is an umlsterm, dentistry is an umlsterm, axis is an umlsterm, plates is an umlsterm, patient is an umlsterm, TMJ is an umlsterm, movement is an umlsterm, mouth is an umlsterm, farward is an umlsterm, incisor is an umlsterm, distance is an umlsterm, plates is an umlsterm, TMJ is an umlsterm, skull - mounted is an umlsterm, plate is an umlsterm, tips is an umlsterm, electronic is an umlsterm, plates is an umlsterm, mandible is an umlsterm, face is an umlsterm, teeth is an umlsterm, face is an umlsterm, patient is an umlsterm, mask is an umlsterm, ventilation is an umlsterm, movement is an umlsterm, laryngoscope is an umlsterm, intubation is an umlsterm, projections is an umlsterm, operating theatre is an umlsterm, endotracheal intubation is an umlsterm, head is an umlsterm, ethics committee is an umlsterm, male is an umlsterm, patients is an umlsterm, ASA is an umlsterm, Mallampati is an umlsterm, limb is an umlsterm, surgery is an umlsterm, intubation is an umlsterm, suxamethonium is an umlsterm, intubation is an umlsterm, vecuronium is an umlsterm, intubation is an umlsterm, suxamethonium is an umlsterm, intubation is an umlsterm, vecuronium is an umlsterm, Intubation is an umlsterm, injection is an umlsterm, findings is an umlsterm, movements is an umlsterm, mandible is an umlsterm, mouth is an umlsterm, dysfunction is an umlsterm, TMJ is an umlsterm, pain is an umlsterm, sensation is an umlsterm, TMJ is an umlsterm, intubations is an umlsterm, TMJ is an umlsterm, movements is an umlsterm, intubation is an umlsterm, method is an umlsterm, TMJ is an umlsterm, movements is an umlsterm, endotracheal intubation is an umlsterm, time is an umlsterm, techniques is an umlsterm, instruments is an umlsterm, intubation is an umlsterm, movements is an umlsterm, endotracheal intubation is an umlsterm	DerAnaesthesist.60450907.eng.abstr_task1	Sentence: Laryngoscopy causes temporary postoperative dysfunction of the temporomandibular joint ( TMJ ) : during iatrogenic TMJ manipulation in anaesthetised patients , the TMJs have lost the protection afforded by the tone of the surrounding muscles . Thus far , the exact type and extent of TMJ movements have not been known . The purpose of this study was to develop a method to visualise and assess TMJ movements during intubation by means of electronic axiography , a diagnostic monitor of TMJ movements used in dentistry : registration of the hinge axis ( HA ) as an equivalent of the condylar paths on extra-oral sagittally mounted , parallel plates . The HA is individually defined in each patient by the pure , rotating TMJ movement during initial mouth opening ( no farward gliding of the condyles , incisor distance up to 10 mm ) . The parallel plates are placed in the TMJ region in the skull-mounted plate bow ; both registration tips ( " drawing " the HA tracings on the electronic plates ) are connected to the mandible by a face bow , paraocclusally fixed to the teeth . The face bow is individually shaped for each patient to allow mask ventilation and free movement of the laryngoscope during intubation . HA tracings are registered and calculated for both sides independently every 24 ms with the SAM/Klett system and presented on sagittal and frontal projections . In the operating theatre , the active mouth-opening traces ( MOT ) are registered first and the passive endotracheal intubation traces ( EIT ) after induction of anaesthesia ( same head position ) . With informed consent and approval by the ethics committee of the Landesaerztekammer Rheinland-Pfalz , 40 male patients ( ASA I , Mallampati I , limb surgery ) were randomly allocated to four groups ( n=10 each ) . OS : Oral intubation , suxamethonium ( 1.5 mg/kg ) ; OV : Oral intubation , vecuronium ( 0.1 mg/kg ) ; NS : Nasal intubation , suxamethonium ( 1.5 mg/kg ) ; and NV : Nasal intubation , vecuronium ( 0.1 mg/kg ) . Intubation was performed 100 s after injection of the relaxant . Pre- and postoperatively ( every 24 h over 3 days , in case of positive findings longer ) recorded were : active movements of the mandible ( maximal mouth opening/max . laterotrusion ) ; dysfunction of the TMJ ; and pain sensation in the TMJ ( Helkimo rating ) . MOTs and EITs were recorded and analysed with the system described and typical EIT patterns were identified : bland , clinically uneventful intubations ( n=7), massive distraction and laterotrusion of the EIT compared to the MOT ( n=24), and blocked or limited TMJ movements resulting in intubation problems ( n=1). With the method presented , TMJ movements could be visualised during endotracheal intubation for the first time . It can be used to assess techniques , routes , and instruments for intubation as well as to evaluate potential traumatising movements during endotracheal intubation . Instructions: please typing these entity words according to sentence: Laryngoscopy, postoperative, dysfunction, temporomandibular joint, TMJ, TMJ, patients, muscles, exact, TMJ, movements, method, TMJ, movements, intubation, electronic, axiography, diagnostic, monitor, TMJ, movements, dentistry, axis, plates, patient, TMJ, movement, mouth, farward, incisor, distance, plates, TMJ, skull - mounted, plate, tips, electronic, plates, mandible, face, teeth, face, patient, mask, ventilation, movement, laryngoscope, intubation, projections, operating theatre, endotracheal intubation, head, ethics committee, male, patients, ASA, Mallampati, limb, surgery, intubation, suxamethonium, intubation, vecuronium, intubation, suxamethonium, intubation, vecuronium, Intubation, injection, findings, movements, mandible, mouth, dysfunction, TMJ, pain, sensation, TMJ, intubations, TMJ, movements, intubation, method, TMJ, movements, endotracheal intubation, time, techniques, instruments, intubation, movements, endotracheal intubation Options: umlsterm	[ "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O" ]	Laryngoscopy causes temporary postoperative dysfunction of the temporomandibular joint ( TMJ ) : during iatrogenic TMJ manipulation in anaesthetised patients , the TMJs have lost the protection afforded by the tone of the surrounding muscles . Thus far , the exact type and extent of TMJ movements have not been known . The purpose of this study was to develop a method to visualise and assess TMJ movements during intubation by means of electronic axiography , a diagnostic monitor of TMJ movements used in dentistry : registration of the hinge axis ( HA ) as an equivalent of the condylar paths on extra-oral sagittally mounted , parallel plates . The HA is individually defined in each patient by the pure , rotating TMJ movement during initial mouth opening ( no farward gliding of the condyles , incisor distance up to 10 mm ) . The parallel plates are placed in the TMJ region in the skull-mounted plate bow ; both registration tips ( " drawing " the HA tracings on the electronic plates ) are connected to the mandible by a face bow , paraocclusally fixed to the teeth . The face bow is individually shaped for each patient to allow mask ventilation and free movement of the laryngoscope during intubation . HA tracings are registered and calculated for both sides independently every 24 ms with the SAM/Klett system and presented on sagittal and frontal projections . In the operating theatre , the active mouth-opening traces ( MOT ) are registered first and the passive endotracheal intubation traces ( EIT ) after induction of anaesthesia ( same head position ) . With informed consent and approval by the ethics committee of the Landesaerztekammer Rheinland-Pfalz , 40 male patients ( ASA I , Mallampati I , limb surgery ) were randomly allocated to four groups ( n=10 each ) . OS : Oral intubation , suxamethonium ( 1.5 mg/kg ) ; OV : Oral intubation , vecuronium ( 0.1 mg/kg ) ; NS : Nasal intubation , suxamethonium ( 1.5 mg/kg ) ; and NV : Nasal intubation , vecuronium ( 0.1 mg/kg ) . Intubation was performed 100 s after injection of the relaxant . Pre- and postoperatively ( every 24 h over 3 days , in case of positive findings longer ) recorded were : active movements of the mandible ( maximal mouth opening/max . laterotrusion ) ; dysfunction of the TMJ ; and pain sensation in the TMJ ( Helkimo rating ) . MOTs and EITs were recorded and analysed with the system described and typical EIT patterns were identified : bland , clinically uneventful intubations ( n=7), massive distraction and laterotrusion of the EIT compared to the MOT ( n=24), and blocked or limited TMJ movements resulting in intubation problems ( n=1). With the method presented , TMJ movements could be visualised during endotracheal intubation for the first time . It can be used to assess techniques , routes , and instruments for intubation as well as to evaluate potential traumatising movements during endotracheal intubation .	[ "Laryngoscopy", "causes", "temporary", "postoperative", "dysfunction", "of", "the", "temporomandibular", "joint", "(", "TMJ", ")", ":", "during", "iatrogenic", "TMJ", "manipulation", "in", "anaesthetised", "patients", ",", "the", "TMJs", "have", "lost", "the", "protection", "afforded", "by", "the", "tone", "of", "the", "surrounding", "muscles", ".", "Thus", "far", ",", "the", "exact", "type", "and", "extent", "of", "TMJ", "movements", "have", "not", "been", "known", ".", "The", "purpose", "of", "this", "study", "was", "to", "develop", "a", "method", "to", "visualise", "and", "assess", "TMJ", "movements", "during", "intubation", "by", "means", "of", "electronic", "axiography", ",", "a", "diagnostic", "monitor", "of", "TMJ", "movements", "used", "in", "dentistry", ":", "registration", "of", "the", "hinge", "axis", "(", "HA", ")", "as", "an", "equivalent", "of", "the", "condylar", "paths", "on", "extra", "-", "oral", "sagittally", "mounted", ",", "parallel", "plates", ".", "The", "HA", "is", "individually", "defined", "in", "each", "patient", "by", "the", "pure", ",", "rotating", "TMJ", "movement", "during", "initial", "mouth", "opening", "(", "no", "farward", "gliding", "of", "the", "condyles", ",", "incisor", "distance", "up", "to", "10", "mm", ")", ".", "The", "parallel", "plates", "are", "placed", "in", "the", "TMJ", "region", "in", "the", "skull", "-", "mounted", "plate", "bow", ";", "both", "registration", "tips", "(", "\"", "drawing", "\"", "the", "HA", "tracings", "on", "the", "electronic", "plates", ")", "are", "connected", "to", "the", "mandible", "by", "a", "face", "bow", ",", "paraocclusally", "fixed", "to", "the", "teeth", ".", "The", "face", "bow", "is", "individually", "shaped", "for", "each", "patient", "to", "allow", "mask", "ventilation", "and", "free", "movement", "of", "the", "laryngoscope", "during", "intubation", ".", "HA", "tracings", "are", "registered", "and", "calculated", "for", "both", "sides", "independently", "every", "24", "ms", "with", "the", "SAM", "/", "Klett", "system", "and", "presented", "on", "sagittal", "and", "frontal", "projections", ".", "In", "the", "operating", "theatre", ",", "the", "active", "mouth", "-", "opening", "traces", "(", "MOT", ")", "are", "registered", "first", "and", "the", "passive", "endotracheal", "intubation", "traces", "(", "EIT", ")", "after", "induction", "of", "anaesthesia", "(", "same", "head", "position", ")", ".", "With", "informed", "consent", "and", "approval", "by", "the", "ethics", "committee", "of", "the", "Landesaerztekammer", "Rheinland", "-", "Pfalz", ",", "40", "male", "patients", "(", "ASA", "I", ",", "Mallampati", "I", ",", "limb", "surgery", ")", "were", "randomly", "allocated", "to", "four", "groups", "(", "n=10", "each", ")", ".", "OS", ":", "Oral", "intubation", ",", "suxamethonium", "(", "1.5", "mg", "/", "kg", ")", ";", "OV", ":", "Oral", "intubation", ",", "vecuronium", "(", "0.1", "mg", "/", "kg", ")", ";", "NS", ":", "Nasal", "intubation", ",", "suxamethonium", "(", "1.5", "mg", "/", "kg", ")", ";", "and", "NV", ":", "Nasal", "intubation", ",", "vecuronium", "(", "0.1", "mg", "/", "kg", ")", ".", "Intubation", "was", "performed", "100", "s", "after", "injection", "of", "the", "relaxant", ".", "Pre-", "and", "postoperatively", "(", "every", "24", "h", "over", "3", "days", ",", "in", "case", "of", "positive", "findings", "longer", ")", "recorded", "were", ":", "active", "movements", "of", "the", "mandible", "(", "maximal", "mouth", "opening", "/", "max", ".", "laterotrusion", ")", ";", "dysfunction", "of", "the", "TMJ", ";", "and", "pain", "sensation", "in", "the", "TMJ", "(", "Helkimo", "rating", ")", ".", "MOTs", "and", "EITs", "were", "recorded", "and", "analysed", "with", "the", "system", "described", "and", "typical", "EIT", "patterns", "were", "identified", ":", "bland", ",", "clinically", "uneventful", "intubations", "(", "n=7", ")", ",", "massive", "distraction", "and", "laterotrusion", "of", "the", "EIT", "compared", "to", "the", "MOT", "(", "n=24", ")", ",", "and", "blocked", "or", "limited", "TMJ", "movements", "resulting", "in", "intubation", "problems", "(", "n=1", ")", ".", "With", "the", "method", "presented", ",", "TMJ", "movements", "could", "be", "visualised", "during", "endotracheal", "intubation", "for", "the", "first", "time", ".", "It", "can", "be", "used", "to", "assess", "techniques", ",", "routes", ",", "and", "instruments", "for", "intubation", "as", "well", "as", "to", "evaluate", "potential", "traumatising", "movements", "during", "endotracheal", "intubation", "." ]	[ "umlsterm" ]
Laryngoscopy, postoperative, dysfunction, temporomandibular joint, TMJ, TMJ, patients, muscles, exact, TMJ, movements, method, TMJ, movements, intubation, electronic, axiography, diagnostic, monitor, TMJ, movements, dentistry, axis, plates, patient, TMJ, movement, mouth, farward, incisor, distance, plates, TMJ, skull - mounted, plate, tips, electronic, plates, mandible, face, teeth, face, patient, mask, ventilation, movement, laryngoscope, intubation, projections, operating theatre, endotracheal intubation, head, ethics committee, male, patients, ASA, Mallampati, limb, surgery, intubation, suxamethonium, intubation, vecuronium, intubation, suxamethonium, intubation, vecuronium, Intubation, injection, findings, movements, mandible, mouth, dysfunction, TMJ, pain, sensation, TMJ, intubations, TMJ, movements, intubation, method, TMJ, movements, endotracheal intubation, time, techniques, instruments, intubation, movements, endotracheal intubation	DerAnaesthesist.60450907.eng.abstr_task2	Sentence: Laryngoscopy causes temporary postoperative dysfunction of the temporomandibular joint ( TMJ ) : during iatrogenic TMJ manipulation in anaesthetised patients , the TMJs have lost the protection afforded by the tone of the surrounding muscles . Thus far , the exact type and extent of TMJ movements have not been known . The purpose of this study was to develop a method to visualise and assess TMJ movements during intubation by means of electronic axiography , a diagnostic monitor of TMJ movements used in dentistry : registration of the hinge axis ( HA ) as an equivalent of the condylar paths on extra-oral sagittally mounted , parallel plates . The HA is individually defined in each patient by the pure , rotating TMJ movement during initial mouth opening ( no farward gliding of the condyles , incisor distance up to 10 mm ) . The parallel plates are placed in the TMJ region in the skull-mounted plate bow ; both registration tips ( " drawing " the HA tracings on the electronic plates ) are connected to the mandible by a face bow , paraocclusally fixed to the teeth . The face bow is individually shaped for each patient to allow mask ventilation and free movement of the laryngoscope during intubation . HA tracings are registered and calculated for both sides independently every 24 ms with the SAM/Klett system and presented on sagittal and frontal projections . In the operating theatre , the active mouth-opening traces ( MOT ) are registered first and the passive endotracheal intubation traces ( EIT ) after induction of anaesthesia ( same head position ) . With informed consent and approval by the ethics committee of the Landesaerztekammer Rheinland-Pfalz , 40 male patients ( ASA I , Mallampati I , limb surgery ) were randomly allocated to four groups ( n=10 each ) . OS : Oral intubation , suxamethonium ( 1.5 mg/kg ) ; OV : Oral intubation , vecuronium ( 0.1 mg/kg ) ; NS : Nasal intubation , suxamethonium ( 1.5 mg/kg ) ; and NV : Nasal intubation , vecuronium ( 0.1 mg/kg ) . Intubation was performed 100 s after injection of the relaxant . Pre- and postoperatively ( every 24 h over 3 days , in case of positive findings longer ) recorded were : active movements of the mandible ( maximal mouth opening/max . laterotrusion ) ; dysfunction of the TMJ ; and pain sensation in the TMJ ( Helkimo rating ) . MOTs and EITs were recorded and analysed with the system described and typical EIT patterns were identified : bland , clinically uneventful intubations ( n=7), massive distraction and laterotrusion of the EIT compared to the MOT ( n=24), and blocked or limited TMJ movements resulting in intubation problems ( n=1). With the method presented , TMJ movements could be visualised during endotracheal intubation for the first time . It can be used to assess techniques , routes , and instruments for intubation as well as to evaluate potential traumatising movements during endotracheal intubation . 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Thus far , the exact type and extent of TMJ movements have not been known . The purpose of this study was to develop a method to visualise and assess TMJ movements during intubation by means of electronic axiography , a diagnostic monitor of TMJ movements used in dentistry : registration of the hinge axis ( HA ) as an equivalent of the condylar paths on extra-oral sagittally mounted , parallel plates . The HA is individually defined in each patient by the pure , rotating TMJ movement during initial mouth opening ( no farward gliding of the condyles , incisor distance up to 10 mm ) . The parallel plates are placed in the TMJ region in the skull-mounted plate bow ; both registration tips ( " drawing " the HA tracings on the electronic plates ) are connected to the mandible by a face bow , paraocclusally fixed to the teeth . The face bow is individually shaped for each patient to allow mask ventilation and free movement of the laryngoscope during intubation . HA tracings are registered and calculated for both sides independently every 24 ms with the SAM/Klett system and presented on sagittal and frontal projections . In the operating theatre , the active mouth-opening traces ( MOT ) are registered first and the passive endotracheal intubation traces ( EIT ) after induction of anaesthesia ( same head position ) . With informed consent and approval by the ethics committee of the Landesaerztekammer Rheinland-Pfalz , 40 male patients ( ASA I , Mallampati I , limb surgery ) were randomly allocated to four groups ( n=10 each ) . OS : Oral intubation , suxamethonium ( 1.5 mg/kg ) ; OV : Oral intubation , vecuronium ( 0.1 mg/kg ) ; NS : Nasal intubation , suxamethonium ( 1.5 mg/kg ) ; and NV : Nasal intubation , vecuronium ( 0.1 mg/kg ) . Intubation was performed 100 s after injection of the relaxant . Pre- and postoperatively ( every 24 h over 3 days , in case of positive findings longer ) recorded were : active movements of the mandible ( maximal mouth opening/max . laterotrusion ) ; dysfunction of the TMJ ; and pain sensation in the TMJ ( Helkimo rating ) . MOTs and EITs were recorded and analysed with the system described and typical EIT patterns were identified : bland , clinically uneventful intubations ( n=7), massive distraction and laterotrusion of the EIT compared to the MOT ( n=24), and blocked or limited TMJ movements resulting in intubation problems ( n=1). With the method presented , TMJ movements could be visualised during endotracheal intubation for the first time . It can be used to assess techniques , routes , and instruments for intubation as well as to evaluate potential traumatising movements during endotracheal intubation .	[ "Laryngoscopy", "causes", "temporary", "postoperative", "dysfunction", "of", "the", "temporomandibular", "joint", "(", "TMJ", ")", ":", "during", "iatrogenic", "TMJ", "manipulation", "in", "anaesthetised", "patients", ",", "the", "TMJs", "have", "lost", "the", "protection", "afforded", "by", "the", "tone", "of", "the", "surrounding", "muscles", ".", "Thus", "far", ",", "the", "exact", "type", "and", "extent", "of", "TMJ", "movements", "have", "not", "been", "known", ".", "The", "purpose", "of", "this", "study", "was", "to", "develop", "a", "method", "to", "visualise", "and", "assess", "TMJ", "movements", "during", "intubation", "by", "means", "of", "electronic", "axiography", ",", "a", "diagnostic", "monitor", "of", "TMJ", "movements", "used", "in", "dentistry", ":", "registration", "of", "the", "hinge", "axis", "(", "HA", ")", "as", "an", "equivalent", "of", "the", "condylar", "paths", "on", "extra", "-", "oral", "sagittally", "mounted", ",", "parallel", "plates", ".", "The", "HA", "is", "individually", "defined", "in", "each", "patient", "by", "the", "pure", ",", "rotating", "TMJ", "movement", "during", "initial", "mouth", "opening", "(", "no", "farward", "gliding", "of", "the", "condyles", ",", "incisor", "distance", "up", "to", "10", "mm", ")", ".", "The", "parallel", "plates", "are", "placed", "in", "the", "TMJ", "region", "in", "the", "skull", "-", "mounted", "plate", "bow", ";", "both", "registration", "tips", "(", "\"", "drawing", "\"", "the", "HA", "tracings", "on", "the", "electronic", "plates", ")", "are", "connected", "to", "the", "mandible", "by", "a", "face", "bow", ",", "paraocclusally", "fixed", "to", "the", "teeth", ".", "The", "face", "bow", "is", "individually", "shaped", "for", "each", "patient", "to", "allow", "mask", "ventilation", "and", "free", "movement", "of", "the", "laryngoscope", "during", "intubation", ".", "HA", "tracings", "are", "registered", "and", "calculated", "for", "both", "sides", "independently", "every", "24", "ms", "with", "the", "SAM", "/", "Klett", "system", "and", "presented", "on", "sagittal", "and", "frontal", "projections", ".", "In", "the", "operating", "theatre", ",", "the", "active", "mouth", "-", "opening", "traces", "(", "MOT", ")", "are", "registered", "first", "and", "the", "passive", "endotracheal", "intubation", "traces", "(", "EIT", ")", "after", "induction", "of", "anaesthesia", "(", "same", "head", "position", ")", ".", "With", "informed", "consent", "and", "approval", "by", "the", "ethics", "committee", "of", "the", "Landesaerztekammer", "Rheinland", "-", "Pfalz", ",", "40", "male", "patients", "(", "ASA", "I", ",", "Mallampati", "I", ",", "limb", "surgery", ")", "were", "randomly", "allocated", "to", "four", "groups", "(", "n=10", "each", ")", ".", "OS", ":", "Oral", "intubation", ",", "suxamethonium", "(", "1.5", "mg", "/", "kg", ")", ";", "OV", ":", "Oral", "intubation", ",", "vecuronium", "(", "0.1", "mg", "/", "kg", ")", ";", "NS", ":", "Nasal", "intubation", ",", "suxamethonium", "(", "1.5", "mg", "/", "kg", ")", ";", "and", "NV", ":", "Nasal", "intubation", ",", "vecuronium", "(", "0.1", "mg", "/", "kg", ")", ".", "Intubation", "was", "performed", "100", "s", "after", "injection", "of", "the", "relaxant", ".", "Pre-", "and", "postoperatively", "(", "every", "24", "h", "over", "3", "days", ",", "in", "case", "of", "positive", "findings", "longer", ")", "recorded", "were", ":", "active", "movements", "of", "the", "mandible", "(", "maximal", "mouth", "opening", "/", "max", ".", "laterotrusion", ")", ";", "dysfunction", "of", "the", "TMJ", ";", "and", "pain", "sensation", "in", "the", "TMJ", "(", "Helkimo", "rating", ")", ".", "MOTs", "and", "EITs", "were", "recorded", "and", "analysed", "with", "the", "system", "described", "and", "typical", "EIT", "patterns", "were", "identified", ":", "bland", ",", "clinically", "uneventful", "intubations", "(", "n=7", ")", ",", "massive", "distraction", "and", "laterotrusion", "of", "the", "EIT", "compared", "to", "the", "MOT", "(", "n=24", ")", ",", "and", "blocked", "or", "limited", "TMJ", "movements", "resulting", "in", "intubation", "problems", "(", "n=1", ")", ".", "With", "the", "method", "presented", ",", "TMJ", "movements", "could", "be", "visualised", "during", "endotracheal", "intubation", "for", "the", "first", "time", ".", "It", "can", "be", "used", "to", "assess", "techniques", ",", "routes", ",", "and", "instruments", "for", "intubation", "as", "well", "as", "to", "evaluate", "potential", "traumatising", "movements", "during", "endotracheal", "intubation", "." ]	[ "umlsterm" ]
Prozessanalyse is an umlsterm, Verzoegerungen is an umlsterm, Patienten is an umlsterm	Notfall+Rettungsmedizin.90020274.ger.abstr_task0	Sentence: Am Beispiel eines innerstaedtischen Notarztsystems wurde eine prospektive Prozessanalyse auf der Basis der Definitionen des Utstein-Style " " durchgefuehrt . Untersucht wurden Verzoegerungen und Unterbrechungen im organisatorischen , medizinischen und medizinisch-technischen Bereich bei ausserklinischen Wiederbelebungsmassnahmen anhand eines Kollektiv von n=71 reanimationspflichtigen Patienten . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Am Beispiel eines innerstaedtischen Notarztsystems wurde eine prospektive Prozessanalyse auf der Basis der Definitionen des Utstein-Style " " durchgefuehrt . Untersucht wurden Verzoegerungen und Unterbrechungen im organisatorischen , medizinischen und medizinisch-technischen Bereich bei ausserklinischen Wiederbelebungsmassnahmen anhand eines Kollektiv von n=71 reanimationspflichtigen Patienten .	[ "Am", "Beispiel", "eines", "innerstaedtischen", "Notarztsystems", "wurde", "eine", "prospektive", "Prozessanalyse", "auf", "der", "Basis", "der", "Definitionen", "des", "Utstein", "-", "Style", "\"", "\"", "durchgefuehrt", ".", "Untersucht", "wurden", "Verzoegerungen", "und", "Unterbrechungen", "im", "organisatorischen", ",", "medizinischen", "und", "medizinisch", "-", "technischen", "Bereich", "bei", "ausserklinischen", "Wiederbelebungsmassnahmen", "anhand", "eines", "Kollektiv", "von", "n=71", "reanimationspflichtigen", "Patienten", "." ]	[ "umlsterm" ]
Prozessanalyse is an umlsterm, Verzoegerungen is an umlsterm, Patienten is an umlsterm	Notfall+Rettungsmedizin.90020274.ger.abstr_task1	Sentence: Am Beispiel eines innerstaedtischen Notarztsystems wurde eine prospektive Prozessanalyse auf der Basis der Definitionen des Utstein-Style " " durchgefuehrt . Untersucht wurden Verzoegerungen und Unterbrechungen im organisatorischen , medizinischen und medizinisch-technischen Bereich bei ausserklinischen Wiederbelebungsmassnahmen anhand eines Kollektiv von n=71 reanimationspflichtigen Patienten . Instructions: please typing these entity words according to sentence: Prozessanalyse, Verzoegerungen, Patienten Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Am Beispiel eines innerstaedtischen Notarztsystems wurde eine prospektive Prozessanalyse auf der Basis der Definitionen des Utstein-Style " " durchgefuehrt . Untersucht wurden Verzoegerungen und Unterbrechungen im organisatorischen , medizinischen und medizinisch-technischen Bereich bei ausserklinischen Wiederbelebungsmassnahmen anhand eines Kollektiv von n=71 reanimationspflichtigen Patienten .	[ "Am", "Beispiel", "eines", "innerstaedtischen", "Notarztsystems", "wurde", "eine", "prospektive", "Prozessanalyse", "auf", "der", "Basis", "der", "Definitionen", "des", "Utstein", "-", "Style", "\"", "\"", "durchgefuehrt", ".", "Untersucht", "wurden", "Verzoegerungen", "und", "Unterbrechungen", "im", "organisatorischen", ",", "medizinischen", "und", "medizinisch", "-", "technischen", "Bereich", "bei", "ausserklinischen", "Wiederbelebungsmassnahmen", "anhand", "eines", "Kollektiv", "von", "n=71", "reanimationspflichtigen", "Patienten", "." ]	[ "umlsterm" ]
Prozessanalyse, Verzoegerungen, Patienten	Notfall+Rettungsmedizin.90020274.ger.abstr_task2	Sentence: Am Beispiel eines innerstaedtischen Notarztsystems wurde eine prospektive Prozessanalyse auf der Basis der Definitionen des Utstein-Style " " durchgefuehrt . Untersucht wurden Verzoegerungen und Unterbrechungen im organisatorischen , medizinischen und medizinisch-technischen Bereich bei ausserklinischen Wiederbelebungsmassnahmen anhand eines Kollektiv von n=71 reanimationspflichtigen Patienten . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Am Beispiel eines innerstaedtischen Notarztsystems wurde eine prospektive Prozessanalyse auf der Basis der Definitionen des Utstein-Style " " durchgefuehrt . Untersucht wurden Verzoegerungen und Unterbrechungen im organisatorischen , medizinischen und medizinisch-technischen Bereich bei ausserklinischen Wiederbelebungsmassnahmen anhand eines Kollektiv von n=71 reanimationspflichtigen Patienten .	[ "Am", "Beispiel", "eines", "innerstaedtischen", "Notarztsystems", "wurde", "eine", "prospektive", "Prozessanalyse", "auf", "der", "Basis", "der", "Definitionen", "des", "Utstein", "-", "Style", "\"", "\"", "durchgefuehrt", ".", "Untersucht", "wurden", "Verzoegerungen", "und", "Unterbrechungen", "im", "organisatorischen", ",", "medizinischen", "und", "medizinisch", "-", "technischen", "Bereich", "bei", "ausserklinischen", "Wiederbelebungsmassnahmen", "anhand", "eines", "Kollektiv", "von", "n=71", "reanimationspflichtigen", "Patienten", "." ]	[ "umlsterm" ]
beta 3-adrenoceptor is a GENE-Y, BRL35135 is a CHEMICAL, beta 3-adrenoceptor is a GENE-Y, BRL35135 is a CHEMICAL, beta 3-receptors is a GENE-Y, BRL35135 is a CHEMICAL, BRL is a CHEMICAL, beta 2-adrenoceptor is a GENE-Y, salbutamol is a CHEMICAL, SAL is a CHEMICAL, bisoprolol is a CHEMICAL, beta 1-adrenoceptor is a GENE-Y, nadolol is a CHEMICAL, beta 1- and beta 2- but not beta 3-receptors is a GENE-N, BRL is a CHEMICAL, SAL is a CHEMICAL, beta 2-adrenoceptor is a GENE-Y, BRL is a CHEMICAL, SAL is a CHEMICAL, BRL is a CHEMICAL, SAL is a CHEMICAL, beta 1-adrenoceptor is a GENE-Y, SAL is a CHEMICAL, BRL is a CHEMICAL, BRL is a CHEMICAL	28688_task0	Sentence: Cardiac effects of the beta 3-adrenoceptor agonist BRL35135 in man. The aim of the present study was to evaluate the cardiac effects of the beta 3-adrenoceptor agonist BRL35135, and determine whether beta 3-receptors are involved in mediating chronotropic or inotropic responses in man. Eight normal males received single oral doses of BRL35135 8 mg (BRL) or the selective beta 2-adrenoceptor agonist salbutamol 8 mg (SAL), after pretreatment with either placebo (PL), bisoprolol 5 mg (B5) as a selective beta 1-adrenoceptor antagonist, or nadolol 20 mg (N20) to block beta 1- and beta 2- but not beta 3-receptors. Both BRL and SAL produced a significant increase in postural finger tremor in keeping with beta 2-adrenoceptor stimulation, and this response was totally abolished by pretreatment with N20. Significant increases in systolic blood pressure and Doppler stroke distance occurred with BRL and SAL which were unaffected by pretreatment with B5 and completely blocked by N20, in keeping with beta 2-mediated effects. BRL and SAL produced significant chronotropic and minute distance responses which were unaffected by beta 1-adrenoceptor blockade. However, whereas N20 blocked these responses to SAL, a small but significant response occurred with BRL in comparison with placebo despite complete blockade of co-existing beta 2-mediated effects. Compared with PL, the mean responses to N20/BRL, and the 95% confidence interval for the differences between the means were 7.4 beats min-1 [3.2 to 11.6] (P = 0.002) for heart rate, and 208.8 cm [38.3 to 379.3] (P = 0.02) for minute distance responses.(ABSTRACT TRUNCATED AT 250 WORDS) Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N, GENE-Y, CHEMICAL	[ "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "B-CHEMICAL", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "B-CHEMICAL", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Cardiac effects of the beta 3-adrenoceptor agonist BRL35135 in man. The aim of the present study was to evaluate the cardiac effects of the beta 3-adrenoceptor agonist BRL35135, and determine whether beta 3-receptors are involved in mediating chronotropic or inotropic responses in man. Eight normal males received single oral doses of BRL35135 8 mg (BRL) or the selective beta 2-adrenoceptor agonist salbutamol 8 mg (SAL), after pretreatment with either placebo (PL), bisoprolol 5 mg (B5) as a selective beta 1-adrenoceptor antagonist, or nadolol 20 mg (N20) to block beta 1- and beta 2- but not beta 3-receptors. Both BRL and SAL produced a significant increase in postural finger tremor in keeping with beta 2-adrenoceptor stimulation, and this response was totally abolished by pretreatment with N20. Significant increases in systolic blood pressure and Doppler stroke distance occurred with BRL and SAL which were unaffected by pretreatment with B5 and completely blocked by N20, in keeping with beta 2-mediated effects. BRL and SAL produced significant chronotropic and minute distance responses which were unaffected by beta 1-adrenoceptor blockade. However, whereas N20 blocked these responses to SAL, a small but significant response occurred with BRL in comparison with placebo despite complete blockade of co-existing beta 2-mediated effects. Compared with PL, the mean responses to N20/BRL, and the 95% confidence interval for the differences between the means were 7.4 beats min-1 [3.2 to 11.6] (P = 0.002) for heart rate, and 208.8 cm [38.3 to 379.3] (P = 0.02) for minute distance responses.(ABSTRACT TRUNCATED AT 250 WORDS)	[ "Cardiac", "effects", "of", "the", "beta", "3-adrenoceptor", "agonist", "BRL35135", "in", "man", ".", "\n", "The", "aim", "of", "the", "present", "study", "was", "to", "evaluate", "the", "cardiac", "effects", "of", "the", "beta", "3-adrenoceptor", "agonist", "BRL35135", ",", "and", "determine", "whether", "beta", "3-receptors", "are", "involved", "in", "mediating", "chronotropic", "or", "inotropic", "responses", "in", "man", ".", "Eight", "normal", "males", "received", "single", "oral", "doses", "of", "BRL35135", "8", "mg", "(", "BRL", ")", "or", "the", "selective", "beta", "2-adrenoceptor", "agonist", "salbutamol", "8", "mg", "(", "SAL", ")", ",", "after", "pretreatment", "with", "either", "placebo", "(", "PL", ")", ",", "bisoprolol", "5", "mg", "(", "B5", ")", "as", "a", "selective", "beta", "1-adrenoceptor", "antagonist", ",", "or", "nadolol", "20", "mg", "(", "N20", ")", "to", "block", "beta", "1-", "and", "beta", "2-", "but", "not", "beta", "3-receptors", ".", "Both", "BRL", "and", "SAL", "produced", "a", "significant", "increase", "in", "postural", "finger", "tremor", "in", "keeping", "with", "beta", "2-adrenoceptor", "stimulation", ",", "and", "this", "response", "was", "totally", "abolished", "by", "pretreatment", "with", "N20", ".", "Significant", "increases", "in", "systolic", "blood", "pressure", "and", "Doppler", "stroke", "distance", "occurred", "with", "BRL", "and", "SAL", "which", "were", "unaffected", "by", "pretreatment", "with", "B5", "and", "completely", "blocked", "by", "N20", ",", "in", "keeping", "with", "beta", "2-mediated", "effects", ".", "BRL", "and", "SAL", "produced", "significant", "chronotropic", "and", "minute", "distance", "responses", "which", "were", "unaffected", "by", "beta", "1-adrenoceptor", "blockade", ".", "However", ",", "whereas", "N20", "blocked", "these", "responses", "to", "SAL", ",", "a", "small", "but", "significant", "response", "occurred", "with", "BRL", "in", "comparison", "with", "placebo", "despite", "complete", "blockade", "of", "co", "-", "existing", "beta", "2-mediated", "effects", ".", "Compared", "with", "PL", ",", "the", "mean", "responses", "to", "N20", "/", "BRL", ",", "and", "the", "95", "%", "confidence", "interval", "for", "the", "differences", "between", "the", "means", "were", "7.4", "beats", "min-1", "[", "3.2", "to", "11.6", "]", "(", "P", "=", "0.002", ")", "for", "heart", "rate", ",", "and", "208.8", "cm", "[", "38.3", "to", "379.3", "]", "(", "P", "=", "0.02", ")", "for", "minute", "distance", "responses.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")" ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
beta 3-adrenoceptor is a GENE-Y, BRL35135 is a CHEMICAL, beta 3-adrenoceptor is a GENE-Y, BRL35135 is a CHEMICAL, beta 3-receptors is a GENE-Y, BRL35135 is a CHEMICAL, BRL is a CHEMICAL, beta 2-adrenoceptor is a GENE-Y, salbutamol is a CHEMICAL, SAL is a CHEMICAL, bisoprolol is a CHEMICAL, beta 1-adrenoceptor is a GENE-Y, nadolol is a CHEMICAL, beta 1- and beta 2- but not beta 3-receptors is a GENE-N, BRL is a CHEMICAL, SAL is a CHEMICAL, beta 2-adrenoceptor is a GENE-Y, BRL is a CHEMICAL, SAL is a CHEMICAL, BRL is a CHEMICAL, SAL is a CHEMICAL, beta 1-adrenoceptor is a GENE-Y, SAL is a CHEMICAL, BRL is a CHEMICAL, BRL is a CHEMICAL	28688_task1	Sentence: Cardiac effects of the beta 3-adrenoceptor agonist BRL35135 in man. The aim of the present study was to evaluate the cardiac effects of the beta 3-adrenoceptor agonist BRL35135, and determine whether beta 3-receptors are involved in mediating chronotropic or inotropic responses in man. Eight normal males received single oral doses of BRL35135 8 mg (BRL) or the selective beta 2-adrenoceptor agonist salbutamol 8 mg (SAL), after pretreatment with either placebo (PL), bisoprolol 5 mg (B5) as a selective beta 1-adrenoceptor antagonist, or nadolol 20 mg (N20) to block beta 1- and beta 2- but not beta 3-receptors. Both BRL and SAL produced a significant increase in postural finger tremor in keeping with beta 2-adrenoceptor stimulation, and this response was totally abolished by pretreatment with N20. Significant increases in systolic blood pressure and Doppler stroke distance occurred with BRL and SAL which were unaffected by pretreatment with B5 and completely blocked by N20, in keeping with beta 2-mediated effects. BRL and SAL produced significant chronotropic and minute distance responses which were unaffected by beta 1-adrenoceptor blockade. However, whereas N20 blocked these responses to SAL, a small but significant response occurred with BRL in comparison with placebo despite complete blockade of co-existing beta 2-mediated effects. Compared with PL, the mean responses to N20/BRL, and the 95% confidence interval for the differences between the means were 7.4 beats min-1 [3.2 to 11.6] (P = 0.002) for heart rate, and 208.8 cm [38.3 to 379.3] (P = 0.02) for minute distance responses.(ABSTRACT TRUNCATED AT 250 WORDS) Instructions: please typing these entity words according to sentence: beta 3-adrenoceptor, BRL35135, beta 3-adrenoceptor, BRL35135, beta 3-receptors, BRL35135, BRL, beta 2-adrenoceptor, salbutamol, SAL, bisoprolol, beta 1-adrenoceptor, nadolol, beta 1- and beta 2- but not beta 3-receptors, BRL, SAL, beta 2-adrenoceptor, BRL, SAL, BRL, SAL, beta 1-adrenoceptor, SAL, BRL, BRL Options: GENE-N, GENE-Y, CHEMICAL	[ "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "B-CHEMICAL", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "B-CHEMICAL", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Cardiac effects of the beta 3-adrenoceptor agonist BRL35135 in man. The aim of the present study was to evaluate the cardiac effects of the beta 3-adrenoceptor agonist BRL35135, and determine whether beta 3-receptors are involved in mediating chronotropic or inotropic responses in man. Eight normal males received single oral doses of BRL35135 8 mg (BRL) or the selective beta 2-adrenoceptor agonist salbutamol 8 mg (SAL), after pretreatment with either placebo (PL), bisoprolol 5 mg (B5) as a selective beta 1-adrenoceptor antagonist, or nadolol 20 mg (N20) to block beta 1- and beta 2- but not beta 3-receptors. Both BRL and SAL produced a significant increase in postural finger tremor in keeping with beta 2-adrenoceptor stimulation, and this response was totally abolished by pretreatment with N20. Significant increases in systolic blood pressure and Doppler stroke distance occurred with BRL and SAL which were unaffected by pretreatment with B5 and completely blocked by N20, in keeping with beta 2-mediated effects. BRL and SAL produced significant chronotropic and minute distance responses which were unaffected by beta 1-adrenoceptor blockade. However, whereas N20 blocked these responses to SAL, a small but significant response occurred with BRL in comparison with placebo despite complete blockade of co-existing beta 2-mediated effects. Compared with PL, the mean responses to N20/BRL, and the 95% confidence interval for the differences between the means were 7.4 beats min-1 [3.2 to 11.6] (P = 0.002) for heart rate, and 208.8 cm [38.3 to 379.3] (P = 0.02) for minute distance responses.(ABSTRACT TRUNCATED AT 250 WORDS)	[ "Cardiac", "effects", "of", "the", "beta", "3-adrenoceptor", "agonist", "BRL35135", "in", "man", ".", "\n", "The", "aim", "of", "the", "present", "study", "was", "to", "evaluate", "the", "cardiac", "effects", "of", "the", "beta", "3-adrenoceptor", "agonist", "BRL35135", ",", "and", "determine", "whether", "beta", "3-receptors", "are", "involved", "in", "mediating", "chronotropic", "or", "inotropic", "responses", "in", "man", ".", "Eight", "normal", "males", "received", "single", "oral", "doses", "of", "BRL35135", "8", "mg", "(", "BRL", ")", "or", "the", "selective", "beta", "2-adrenoceptor", "agonist", "salbutamol", "8", "mg", "(", "SAL", ")", ",", "after", "pretreatment", "with", "either", "placebo", "(", "PL", ")", ",", "bisoprolol", "5", "mg", "(", "B5", ")", "as", "a", "selective", "beta", "1-adrenoceptor", "antagonist", ",", "or", "nadolol", "20", "mg", "(", "N20", ")", "to", "block", "beta", "1-", "and", "beta", "2-", "but", "not", "beta", "3-receptors", ".", "Both", "BRL", "and", "SAL", "produced", "a", "significant", "increase", "in", "postural", "finger", "tremor", "in", "keeping", "with", "beta", "2-adrenoceptor", "stimulation", ",", "and", "this", "response", "was", "totally", "abolished", "by", "pretreatment", "with", "N20", ".", "Significant", "increases", "in", "systolic", "blood", "pressure", "and", "Doppler", "stroke", "distance", "occurred", "with", "BRL", "and", "SAL", "which", "were", "unaffected", "by", "pretreatment", "with", "B5", "and", "completely", "blocked", "by", "N20", ",", "in", "keeping", "with", "beta", "2-mediated", "effects", ".", "BRL", "and", "SAL", "produced", "significant", "chronotropic", "and", "minute", "distance", "responses", "which", "were", "unaffected", "by", "beta", "1-adrenoceptor", "blockade", ".", "However", ",", "whereas", "N20", "blocked", "these", "responses", "to", "SAL", ",", "a", "small", "but", "significant", "response", "occurred", "with", "BRL", "in", "comparison", "with", "placebo", "despite", "complete", "blockade", "of", "co", "-", "existing", "beta", "2-mediated", "effects", ".", "Compared", "with", "PL", ",", "the", "mean", "responses", "to", "N20", "/", "BRL", ",", "and", "the", "95", "%", "confidence", "interval", "for", "the", "differences", "between", "the", "means", "were", "7.4", "beats", "min-1", "[", "3.2", "to", "11.6", "]", "(", "P", "=", "0.002", ")", "for", "heart", "rate", ",", "and", "208.8", "cm", "[", "38.3", "to", "379.3", "]", "(", "P", "=", "0.02", ")", "for", "minute", "distance", "responses.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")" ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
beta 3-adrenoceptor, BRL35135, beta 3-adrenoceptor, BRL35135, beta 3-receptors, BRL35135, BRL, beta 2-adrenoceptor, salbutamol, SAL, bisoprolol, beta 1-adrenoceptor, nadolol, beta 1- and beta 2- but not beta 3-receptors, BRL, SAL, beta 2-adrenoceptor, BRL, SAL, BRL, SAL, beta 1-adrenoceptor, SAL, BRL, BRL	28688_task2	Sentence: Cardiac effects of the beta 3-adrenoceptor agonist BRL35135 in man. The aim of the present study was to evaluate the cardiac effects of the beta 3-adrenoceptor agonist BRL35135, and determine whether beta 3-receptors are involved in mediating chronotropic or inotropic responses in man. Eight normal males received single oral doses of BRL35135 8 mg (BRL) or the selective beta 2-adrenoceptor agonist salbutamol 8 mg (SAL), after pretreatment with either placebo (PL), bisoprolol 5 mg (B5) as a selective beta 1-adrenoceptor antagonist, or nadolol 20 mg (N20) to block beta 1- and beta 2- but not beta 3-receptors. Both BRL and SAL produced a significant increase in postural finger tremor in keeping with beta 2-adrenoceptor stimulation, and this response was totally abolished by pretreatment with N20. Significant increases in systolic blood pressure and Doppler stroke distance occurred with BRL and SAL which were unaffected by pretreatment with B5 and completely blocked by N20, in keeping with beta 2-mediated effects. BRL and SAL produced significant chronotropic and minute distance responses which were unaffected by beta 1-adrenoceptor blockade. However, whereas N20 blocked these responses to SAL, a small but significant response occurred with BRL in comparison with placebo despite complete blockade of co-existing beta 2-mediated effects. Compared with PL, the mean responses to N20/BRL, and the 95% confidence interval for the differences between the means were 7.4 beats min-1 [3.2 to 11.6] (P = 0.002) for heart rate, and 208.8 cm [38.3 to 379.3] (P = 0.02) for minute distance responses.(ABSTRACT TRUNCATED AT 250 WORDS) Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "B-CHEMICAL", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "B-CHEMICAL", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Cardiac effects of the beta 3-adrenoceptor agonist BRL35135 in man. The aim of the present study was to evaluate the cardiac effects of the beta 3-adrenoceptor agonist BRL35135, and determine whether beta 3-receptors are involved in mediating chronotropic or inotropic responses in man. Eight normal males received single oral doses of BRL35135 8 mg (BRL) or the selective beta 2-adrenoceptor agonist salbutamol 8 mg (SAL), after pretreatment with either placebo (PL), bisoprolol 5 mg (B5) as a selective beta 1-adrenoceptor antagonist, or nadolol 20 mg (N20) to block beta 1- and beta 2- but not beta 3-receptors. Both BRL and SAL produced a significant increase in postural finger tremor in keeping with beta 2-adrenoceptor stimulation, and this response was totally abolished by pretreatment with N20. Significant increases in systolic blood pressure and Doppler stroke distance occurred with BRL and SAL which were unaffected by pretreatment with B5 and completely blocked by N20, in keeping with beta 2-mediated effects. BRL and SAL produced significant chronotropic and minute distance responses which were unaffected by beta 1-adrenoceptor blockade. However, whereas N20 blocked these responses to SAL, a small but significant response occurred with BRL in comparison with placebo despite complete blockade of co-existing beta 2-mediated effects. Compared with PL, the mean responses to N20/BRL, and the 95% confidence interval for the differences between the means were 7.4 beats min-1 [3.2 to 11.6] (P = 0.002) for heart rate, and 208.8 cm [38.3 to 379.3] (P = 0.02) for minute distance responses.(ABSTRACT TRUNCATED AT 250 WORDS)	[ "Cardiac", "effects", "of", "the", "beta", "3-adrenoceptor", "agonist", "BRL35135", "in", "man", ".", "\n", "The", "aim", "of", "the", "present", "study", "was", "to", "evaluate", "the", "cardiac", "effects", "of", "the", "beta", "3-adrenoceptor", "agonist", "BRL35135", ",", "and", "determine", "whether", "beta", "3-receptors", "are", "involved", "in", "mediating", "chronotropic", "or", "inotropic", "responses", "in", "man", ".", "Eight", "normal", "males", "received", "single", "oral", "doses", "of", "BRL35135", "8", "mg", "(", "BRL", ")", "or", "the", "selective", "beta", "2-adrenoceptor", "agonist", "salbutamol", "8", "mg", "(", "SAL", ")", ",", "after", "pretreatment", "with", "either", "placebo", "(", "PL", ")", ",", "bisoprolol", "5", "mg", "(", "B5", ")", "as", "a", "selective", "beta", "1-adrenoceptor", "antagonist", ",", "or", "nadolol", "20", "mg", "(", "N20", ")", "to", "block", "beta", "1-", "and", "beta", "2-", "but", "not", "beta", "3-receptors", ".", "Both", "BRL", "and", "SAL", "produced", "a", "significant", "increase", "in", "postural", "finger", "tremor", "in", "keeping", "with", "beta", "2-adrenoceptor", "stimulation", ",", "and", "this", "response", "was", "totally", "abolished", "by", "pretreatment", "with", "N20", ".", "Significant", "increases", "in", "systolic", "blood", "pressure", "and", "Doppler", "stroke", "distance", "occurred", "with", "BRL", "and", "SAL", "which", "were", "unaffected", "by", "pretreatment", "with", "B5", "and", "completely", "blocked", "by", "N20", ",", "in", "keeping", "with", "beta", "2-mediated", "effects", ".", "BRL", "and", "SAL", "produced", "significant", "chronotropic", "and", "minute", "distance", "responses", "which", "were", "unaffected", "by", "beta", "1-adrenoceptor", "blockade", ".", "However", ",", "whereas", "N20", "blocked", "these", "responses", "to", "SAL", ",", "a", "small", "but", "significant", "response", "occurred", "with", "BRL", "in", "comparison", "with", "placebo", "despite", "complete", "blockade", "of", "co", "-", "existing", "beta", "2-mediated", "effects", ".", "Compared", "with", "PL", ",", "the", "mean", "responses", "to", "N20", "/", "BRL", ",", "and", "the", "95", "%", "confidence", "interval", "for", "the", "differences", "between", "the", "means", "were", "7.4", "beats", "min-1", "[", "3.2", "to", "11.6", "]", "(", "P", "=", "0.002", ")", "for", "heart", "rate", ",", "and", "208.8", "cm", "[", "38.3", "to", "379.3", "]", "(", "P", "=", "0.02", ")", "for", "minute", "distance", "responses.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")" ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
paraquat is a CHEMICAL	23523781_task0	Sentence: Pharmacokinetic, neurochemical, stereological and neuropathological studies on the potential effects of paraquat in the substantia nigra pars compacta and striatum of male C57BL/6J mice. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Pharmacokinetic, neurochemical, stereological and neuropathological studies on the potential effects of paraquat in the substantia nigra pars compacta and striatum of male C57BL/6J mice.	[ "Pharmacokinetic", ",", "neurochemical", ",", "stereological", "and", "neuropathological", "studies", "on", "the", "potential", "effects", "of", "paraquat", "in", "the", "substantia", "nigra", "pars", "compacta", "and", "striatum", "of", "male", "C57BL/6J", "mice", "." ]	[ "CHEMICAL", "GENE-Y" ]
paraquat is a CHEMICAL	23523781_task1	Sentence: Pharmacokinetic, neurochemical, stereological and neuropathological studies on the potential effects of paraquat in the substantia nigra pars compacta and striatum of male C57BL/6J mice. Instructions: please typing these entity words according to sentence: paraquat Options: CHEMICAL	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Pharmacokinetic, neurochemical, stereological and neuropathological studies on the potential effects of paraquat in the substantia nigra pars compacta and striatum of male C57BL/6J mice.	[ "Pharmacokinetic", ",", "neurochemical", ",", "stereological", "and", "neuropathological", "studies", "on", "the", "potential", "effects", "of", "paraquat", "in", "the", "substantia", "nigra", "pars", "compacta", "and", "striatum", "of", "male", "C57BL/6J", "mice", "." ]	[ "CHEMICAL", "GENE-Y" ]
paraquat	23523781_task2	Sentence: Pharmacokinetic, neurochemical, stereological and neuropathological studies on the potential effects of paraquat in the substantia nigra pars compacta and striatum of male C57BL/6J mice. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Pharmacokinetic, neurochemical, stereological and neuropathological studies on the potential effects of paraquat in the substantia nigra pars compacta and striatum of male C57BL/6J mice.	[ "Pharmacokinetic", ",", "neurochemical", ",", "stereological", "and", "neuropathological", "studies", "on", "the", "potential", "effects", "of", "paraquat", "in", "the", "substantia", "nigra", "pars", "compacta", "and", "striatum", "of", "male", "C57BL/6J", "mice", "." ]	[ "CHEMICAL", "GENE-Y" ]
Knochentumoren is an umlsterm, Chondrom is an umlsterm, Chondrosarkom is an umlsterm, Beurteilung is an umlsterm, mehrkernige Riesenzellen is an umlsterm, Erkennung is an umlsterm, Zysten is an umlsterm, Zyste is an umlsterm, Kallus is an umlsterm, Osteosarkom is an umlsterm, Chondroblastome is an umlsterm, Riesenzelltumoren is an umlsterm, Osteosarkom is an umlsterm, Knochentumordiagnostik is an umlsterm, Verhaltens is an umlsterm	DerPathologe.60170001.ger.abstr_task0	Sentence: Die diagnostische Konsiliartaetigkeit bei Knochentumoren zeigt , dass ausser bei besonders selten vorkommenden Laesionen Schwierigkeiten in der Einstufung Chondrom - Chondrosarkom , in der Beurteilung von reichlich mehrkernige Riesenzellen enthaltenden Prozessen und in der Erkennung von Laesionen mit sekundaeren Zysten , die eine juvenile oder aneurysmatische Zyste simulieren , bestehen , sowie manchmal in der Unterscheidung Kallus vs. Osteosarkom . De-facto-Fehlinterpretationen betreffen ossifizierende Pseudotumore , die als Osteosarkome , metaphysaere fibroese Defekte und Chondroblastome , die als Riesenzelltumoren eingeschaetzt werden , letztere auch als Osteosarkom . Die Knochentumordiagnostik muss unter Beruecksichtigung der klinischen Daten , insbesondere des Alters und v. a. unter Einbeziehung des Verhaltens der Laesionen in den bildgebenden Verfahren erfolgen . Der Pathologe muss ueber Grundkenntnisse in deren Deutung verfuegen . Die angegebenen typischen Fehlinterpretationen sind so ohne Laboraufwand mit dem gewoehnlichen HE-Schnitt zu vermeiden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Die diagnostische Konsiliartaetigkeit bei Knochentumoren zeigt , dass ausser bei besonders selten vorkommenden Laesionen Schwierigkeiten in der Einstufung Chondrom - Chondrosarkom , in der Beurteilung von reichlich mehrkernige Riesenzellen enthaltenden Prozessen und in der Erkennung von Laesionen mit sekundaeren Zysten , die eine juvenile oder aneurysmatische Zyste simulieren , bestehen , sowie manchmal in der Unterscheidung Kallus vs. Osteosarkom . De-facto-Fehlinterpretationen betreffen ossifizierende Pseudotumore , die als Osteosarkome , metaphysaere fibroese Defekte und Chondroblastome , die als Riesenzelltumoren eingeschaetzt werden , letztere auch als Osteosarkom . Die Knochentumordiagnostik muss unter Beruecksichtigung der klinischen Daten , insbesondere des Alters und v. a. unter Einbeziehung des Verhaltens der Laesionen in den bildgebenden Verfahren erfolgen . Der Pathologe muss ueber Grundkenntnisse in deren Deutung verfuegen . Die angegebenen typischen Fehlinterpretationen sind so ohne Laboraufwand mit dem gewoehnlichen HE-Schnitt zu vermeiden .	[ "Die", "diagnostische", "Konsiliartaetigkeit", "bei", "Knochentumoren", "zeigt", ",", "dass", "ausser", "bei", "besonders", "selten", "vorkommenden", "Laesionen", "Schwierigkeiten", "in", "der", "Einstufung", "Chondrom", "-", "Chondrosarkom", ",", "in", "der", "Beurteilung", "von", "reichlich", "mehrkernige", "Riesenzellen", "enthaltenden", "Prozessen", "und", "in", "der", "Erkennung", "von", "Laesionen", "mit", "sekundaeren", "Zysten", ",", "die", "eine", "juvenile", "oder", "aneurysmatische", "Zyste", "simulieren", ",", "bestehen", ",", "sowie", "manchmal", "in", "der", "Unterscheidung", "Kallus", "vs", ".", "Osteosarkom", ".", "De", "-", "facto", "-", "Fehlinterpretationen", "betreffen", "ossifizierende", "Pseudotumore", ",", "die", "als", "Osteosarkome", ",", "metaphysaere", "fibroese", "Defekte", "und", "Chondroblastome", ",", "die", "als", "Riesenzelltumoren", "eingeschaetzt", "werden", ",", "letztere", "auch", "als", "Osteosarkom", ".", "Die", "Knochentumordiagnostik", "muss", "unter", "Beruecksichtigung", "der", "klinischen", "Daten", ",", "insbesondere", "des", "Alters", "und", "v.", "a.", "unter", "Einbeziehung", "des", "Verhaltens", "der", "Laesionen", "in", "den", "bildgebenden", "Verfahren", "erfolgen", ".", "Der", "Pathologe", "muss", "ueber", "Grundkenntnisse", "in", "deren", "Deutung", "verfuegen", ".", "Die", "angegebenen", "typischen", "Fehlinterpretationen", "sind", "so", "ohne", "Laboraufwand", "mit", "dem", "gewoehnlichen", "HE", "-", "Schnitt", "zu", "vermeiden", "." ]	[ "umlsterm" ]
Knochentumoren is an umlsterm, Chondrom is an umlsterm, Chondrosarkom is an umlsterm, Beurteilung is an umlsterm, mehrkernige Riesenzellen is an umlsterm, Erkennung is an umlsterm, Zysten is an umlsterm, Zyste is an umlsterm, Kallus is an umlsterm, Osteosarkom is an umlsterm, Chondroblastome is an umlsterm, Riesenzelltumoren is an umlsterm, Osteosarkom is an umlsterm, Knochentumordiagnostik is an umlsterm, Verhaltens is an umlsterm	DerPathologe.60170001.ger.abstr_task1	Sentence: Die diagnostische Konsiliartaetigkeit bei Knochentumoren zeigt , dass ausser bei besonders selten vorkommenden Laesionen Schwierigkeiten in der Einstufung Chondrom - Chondrosarkom , in der Beurteilung von reichlich mehrkernige Riesenzellen enthaltenden Prozessen und in der Erkennung von Laesionen mit sekundaeren Zysten , die eine juvenile oder aneurysmatische Zyste simulieren , bestehen , sowie manchmal in der Unterscheidung Kallus vs. Osteosarkom . De-facto-Fehlinterpretationen betreffen ossifizierende Pseudotumore , die als Osteosarkome , metaphysaere fibroese Defekte und Chondroblastome , die als Riesenzelltumoren eingeschaetzt werden , letztere auch als Osteosarkom . Die Knochentumordiagnostik muss unter Beruecksichtigung der klinischen Daten , insbesondere des Alters und v. a. unter Einbeziehung des Verhaltens der Laesionen in den bildgebenden Verfahren erfolgen . Der Pathologe muss ueber Grundkenntnisse in deren Deutung verfuegen . Die angegebenen typischen Fehlinterpretationen sind so ohne Laboraufwand mit dem gewoehnlichen HE-Schnitt zu vermeiden . Instructions: please typing these entity words according to sentence: Knochentumoren, Chondrom, Chondrosarkom, Beurteilung, mehrkernige Riesenzellen, Erkennung, Zysten, Zyste, Kallus, Osteosarkom, Chondroblastome, Riesenzelltumoren, Osteosarkom, Knochentumordiagnostik, Verhaltens Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Die diagnostische Konsiliartaetigkeit bei Knochentumoren zeigt , dass ausser bei besonders selten vorkommenden Laesionen Schwierigkeiten in der Einstufung Chondrom - Chondrosarkom , in der Beurteilung von reichlich mehrkernige Riesenzellen enthaltenden Prozessen und in der Erkennung von Laesionen mit sekundaeren Zysten , die eine juvenile oder aneurysmatische Zyste simulieren , bestehen , sowie manchmal in der Unterscheidung Kallus vs. Osteosarkom . De-facto-Fehlinterpretationen betreffen ossifizierende Pseudotumore , die als Osteosarkome , metaphysaere fibroese Defekte und Chondroblastome , die als Riesenzelltumoren eingeschaetzt werden , letztere auch als Osteosarkom . Die Knochentumordiagnostik muss unter Beruecksichtigung der klinischen Daten , insbesondere des Alters und v. a. unter Einbeziehung des Verhaltens der Laesionen in den bildgebenden Verfahren erfolgen . Der Pathologe muss ueber Grundkenntnisse in deren Deutung verfuegen . Die angegebenen typischen Fehlinterpretationen sind so ohne Laboraufwand mit dem gewoehnlichen HE-Schnitt zu vermeiden .	[ "Die", "diagnostische", "Konsiliartaetigkeit", "bei", "Knochentumoren", "zeigt", ",", "dass", "ausser", "bei", "besonders", "selten", "vorkommenden", "Laesionen", "Schwierigkeiten", "in", "der", "Einstufung", "Chondrom", "-", "Chondrosarkom", ",", "in", "der", "Beurteilung", "von", "reichlich", "mehrkernige", "Riesenzellen", "enthaltenden", "Prozessen", "und", "in", "der", "Erkennung", "von", "Laesionen", "mit", "sekundaeren", "Zysten", ",", "die", "eine", "juvenile", "oder", "aneurysmatische", "Zyste", "simulieren", ",", "bestehen", ",", "sowie", "manchmal", "in", "der", "Unterscheidung", "Kallus", "vs", ".", "Osteosarkom", ".", "De", "-", "facto", "-", "Fehlinterpretationen", "betreffen", "ossifizierende", "Pseudotumore", ",", "die", "als", "Osteosarkome", ",", "metaphysaere", "fibroese", "Defekte", "und", "Chondroblastome", ",", "die", "als", "Riesenzelltumoren", "eingeschaetzt", "werden", ",", "letztere", "auch", "als", "Osteosarkom", ".", "Die", "Knochentumordiagnostik", "muss", "unter", "Beruecksichtigung", "der", "klinischen", "Daten", ",", "insbesondere", "des", "Alters", "und", "v.", "a.", "unter", "Einbeziehung", "des", "Verhaltens", "der", "Laesionen", "in", "den", "bildgebenden", "Verfahren", "erfolgen", ".", "Der", "Pathologe", "muss", "ueber", "Grundkenntnisse", "in", "deren", "Deutung", "verfuegen", ".", "Die", "angegebenen", "typischen", "Fehlinterpretationen", "sind", "so", "ohne", "Laboraufwand", "mit", "dem", "gewoehnlichen", "HE", "-", "Schnitt", "zu", "vermeiden", "." ]	[ "umlsterm" ]
Knochentumoren, Chondrom, Chondrosarkom, Beurteilung, mehrkernige Riesenzellen, Erkennung, Zysten, Zyste, Kallus, Osteosarkom, Chondroblastome, Riesenzelltumoren, Osteosarkom, Knochentumordiagnostik, Verhaltens	DerPathologe.60170001.ger.abstr_task2	Sentence: Die diagnostische Konsiliartaetigkeit bei Knochentumoren zeigt , dass ausser bei besonders selten vorkommenden Laesionen Schwierigkeiten in der Einstufung Chondrom - Chondrosarkom , in der Beurteilung von reichlich mehrkernige Riesenzellen enthaltenden Prozessen und in der Erkennung von Laesionen mit sekundaeren Zysten , die eine juvenile oder aneurysmatische Zyste simulieren , bestehen , sowie manchmal in der Unterscheidung Kallus vs. Osteosarkom . De-facto-Fehlinterpretationen betreffen ossifizierende Pseudotumore , die als Osteosarkome , metaphysaere fibroese Defekte und Chondroblastome , die als Riesenzelltumoren eingeschaetzt werden , letztere auch als Osteosarkom . Die Knochentumordiagnostik muss unter Beruecksichtigung der klinischen Daten , insbesondere des Alters und v. a. unter Einbeziehung des Verhaltens der Laesionen in den bildgebenden Verfahren erfolgen . Der Pathologe muss ueber Grundkenntnisse in deren Deutung verfuegen . Die angegebenen typischen Fehlinterpretationen sind so ohne Laboraufwand mit dem gewoehnlichen HE-Schnitt zu vermeiden . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Die diagnostische Konsiliartaetigkeit bei Knochentumoren zeigt , dass ausser bei besonders selten vorkommenden Laesionen Schwierigkeiten in der Einstufung Chondrom - Chondrosarkom , in der Beurteilung von reichlich mehrkernige Riesenzellen enthaltenden Prozessen und in der Erkennung von Laesionen mit sekundaeren Zysten , die eine juvenile oder aneurysmatische Zyste simulieren , bestehen , sowie manchmal in der Unterscheidung Kallus vs. Osteosarkom . De-facto-Fehlinterpretationen betreffen ossifizierende Pseudotumore , die als Osteosarkome , metaphysaere fibroese Defekte und Chondroblastome , die als Riesenzelltumoren eingeschaetzt werden , letztere auch als Osteosarkom . Die Knochentumordiagnostik muss unter Beruecksichtigung der klinischen Daten , insbesondere des Alters und v. a. unter Einbeziehung des Verhaltens der Laesionen in den bildgebenden Verfahren erfolgen . Der Pathologe muss ueber Grundkenntnisse in deren Deutung verfuegen . Die angegebenen typischen Fehlinterpretationen sind so ohne Laboraufwand mit dem gewoehnlichen HE-Schnitt zu vermeiden .	[ "Die", "diagnostische", "Konsiliartaetigkeit", "bei", "Knochentumoren", "zeigt", ",", "dass", "ausser", "bei", "besonders", "selten", "vorkommenden", "Laesionen", "Schwierigkeiten", "in", "der", "Einstufung", "Chondrom", "-", "Chondrosarkom", ",", "in", "der", "Beurteilung", "von", "reichlich", "mehrkernige", "Riesenzellen", "enthaltenden", "Prozessen", "und", "in", "der", "Erkennung", "von", "Laesionen", "mit", "sekundaeren", "Zysten", ",", "die", "eine", "juvenile", "oder", "aneurysmatische", "Zyste", "simulieren", ",", "bestehen", ",", "sowie", "manchmal", "in", "der", "Unterscheidung", "Kallus", "vs", ".", "Osteosarkom", ".", "De", "-", "facto", "-", "Fehlinterpretationen", "betreffen", "ossifizierende", "Pseudotumore", ",", "die", "als", "Osteosarkome", ",", "metaphysaere", "fibroese", "Defekte", "und", "Chondroblastome", ",", "die", "als", "Riesenzelltumoren", "eingeschaetzt", "werden", ",", "letztere", "auch", "als", "Osteosarkom", ".", "Die", "Knochentumordiagnostik", "muss", "unter", "Beruecksichtigung", "der", "klinischen", "Daten", ",", "insbesondere", "des", "Alters", "und", "v.", "a.", "unter", "Einbeziehung", "des", "Verhaltens", "der", "Laesionen", "in", "den", "bildgebenden", "Verfahren", "erfolgen", ".", "Der", "Pathologe", "muss", "ueber", "Grundkenntnisse", "in", "deren", "Deutung", "verfuegen", ".", "Die", "angegebenen", "typischen", "Fehlinterpretationen", "sind", "so", "ohne", "Laboraufwand", "mit", "dem", "gewoehnlichen", "HE", "-", "Schnitt", "zu", "vermeiden", "." ]	[ "umlsterm" ]
JAK is a GENE-N	23317159_task0	Sentence: JAK inhibitors: pharmacology and clinical activity in chronic myeloprolipherative neoplasms. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N	[ "B-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	JAK inhibitors: pharmacology and clinical activity in chronic myeloprolipherative neoplasms.	[ "JAK", "inhibitors", ":", "pharmacology", "and", "clinical", "activity", "in", "chronic", "myeloprolipherative", "neoplasms", "." ]	[ "GENE-N", "CHEMICAL", "GENE-Y" ]
JAK is a GENE-N	23317159_task1	Sentence: JAK inhibitors: pharmacology and clinical activity in chronic myeloprolipherative neoplasms. Instructions: please typing these entity words according to sentence: JAK Options: GENE-N	[ "B-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	JAK inhibitors: pharmacology and clinical activity in chronic myeloprolipherative neoplasms.	[ "JAK", "inhibitors", ":", "pharmacology", "and", "clinical", "activity", "in", "chronic", "myeloprolipherative", "neoplasms", "." ]	[ "GENE-N", "CHEMICAL", "GENE-Y" ]
JAK	23317159_task2	Sentence: JAK inhibitors: pharmacology and clinical activity in chronic myeloprolipherative neoplasms. Instructions: please extract entity words from the input sentence	[ "B-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	JAK inhibitors: pharmacology and clinical activity in chronic myeloprolipherative neoplasms.	[ "JAK", "inhibitors", ":", "pharmacology", "and", "clinical", "activity", "in", "chronic", "myeloprolipherative", "neoplasms", "." ]	[ "GENE-N", "CHEMICAL", "GENE-Y" ]
woman is an umlsterm, depression is an umlsterm, itching is an umlsterm, John 's is an umlsterm, patchtesting is an umlsterm, testing is an umlsterm, test is an umlsterm, John 's is an umlsterm, medication is an umlsterm	DerHautarzt.70480249.eng.abstr_task0	Sentence: A 61-year-old woman with depression developed recurring elevated itching erythematous lesions in light-exposed areas after taking St. John's Wort-extract for three years . Routine patchtesting did not reveal any relevant reactions and photopatch testing was negative . Using a systemic oral photoprovocation test with St. John's Wort , we were able to demonstrate a decrease of the MED-UVB which was reversible after withdrawal of the medication . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	A 61-year-old woman with depression developed recurring elevated itching erythematous lesions in light-exposed areas after taking St. John's Wort-extract for three years . Routine patchtesting did not reveal any relevant reactions and photopatch testing was negative . Using a systemic oral photoprovocation test with St. John's Wort , we were able to demonstrate a decrease of the MED-UVB which was reversible after withdrawal of the medication .	[ "A", "61-year", "-", "old", "woman", "with", "depression", "developed", "recurring", "elevated", "itching", "erythematous", "lesions", "in", "light", "-", "exposed", "areas", "after", "taking", "St", ".", "John", "'s", "Wort", "-", "extract", "for", "three", "years", ".", "Routine", "patchtesting", "did", "not", "reveal", "any", "relevant", "reactions", "and", "photopatch", "testing", "was", "negative", ".", "Using", "a", "systemic", "oral", "photoprovocation", "test", "with", "St", ".", "John", "'s", "Wort", ",", "we", "were", "able", "to", "demonstrate", "a", "decrease", "of", "the", "MED", "-", "UVB", "which", "was", "reversible", "after", "withdrawal", "of", "the", "medication", "." ]	[ "umlsterm" ]
woman is an umlsterm, depression is an umlsterm, itching is an umlsterm, John 's is an umlsterm, patchtesting is an umlsterm, testing is an umlsterm, test is an umlsterm, John 's is an umlsterm, medication is an umlsterm	DerHautarzt.70480249.eng.abstr_task1	Sentence: A 61-year-old woman with depression developed recurring elevated itching erythematous lesions in light-exposed areas after taking St. John's Wort-extract for three years . Routine patchtesting did not reveal any relevant reactions and photopatch testing was negative . Using a systemic oral photoprovocation test with St. John's Wort , we were able to demonstrate a decrease of the MED-UVB which was reversible after withdrawal of the medication . Instructions: please typing these entity words according to sentence: woman, depression, itching, John 's, patchtesting, testing, test, John 's, medication Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	A 61-year-old woman with depression developed recurring elevated itching erythematous lesions in light-exposed areas after taking St. John's Wort-extract for three years . Routine patchtesting did not reveal any relevant reactions and photopatch testing was negative . Using a systemic oral photoprovocation test with St. John's Wort , we were able to demonstrate a decrease of the MED-UVB which was reversible after withdrawal of the medication .	[ "A", "61-year", "-", "old", "woman", "with", "depression", "developed", "recurring", "elevated", "itching", "erythematous", "lesions", "in", "light", "-", "exposed", "areas", "after", "taking", "St", ".", "John", "'s", "Wort", "-", "extract", "for", "three", "years", ".", "Routine", "patchtesting", "did", "not", "reveal", "any", "relevant", "reactions", "and", "photopatch", "testing", "was", "negative", ".", "Using", "a", "systemic", "oral", "photoprovocation", "test", "with", "St", ".", "John", "'s", "Wort", ",", "we", "were", "able", "to", "demonstrate", "a", "decrease", "of", "the", "MED", "-", "UVB", "which", "was", "reversible", "after", "withdrawal", "of", "the", "medication", "." ]	[ "umlsterm" ]
woman, depression, itching, John 's, patchtesting, testing, test, John 's, medication	DerHautarzt.70480249.eng.abstr_task2	Sentence: A 61-year-old woman with depression developed recurring elevated itching erythematous lesions in light-exposed areas after taking St. John's Wort-extract for three years . Routine patchtesting did not reveal any relevant reactions and photopatch testing was negative . Using a systemic oral photoprovocation test with St. John's Wort , we were able to demonstrate a decrease of the MED-UVB which was reversible after withdrawal of the medication . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	A 61-year-old woman with depression developed recurring elevated itching erythematous lesions in light-exposed areas after taking St. John's Wort-extract for three years . Routine patchtesting did not reveal any relevant reactions and photopatch testing was negative . Using a systemic oral photoprovocation test with St. John's Wort , we were able to demonstrate a decrease of the MED-UVB which was reversible after withdrawal of the medication .	[ "A", "61-year", "-", "old", "woman", "with", "depression", "developed", "recurring", "elevated", "itching", "erythematous", "lesions", "in", "light", "-", "exposed", "areas", "after", "taking", "St", ".", "John", "'s", "Wort", "-", "extract", "for", "three", "years", ".", "Routine", "patchtesting", "did", "not", "reveal", "any", "relevant", "reactions", "and", "photopatch", "testing", "was", "negative", ".", "Using", "a", "systemic", "oral", "photoprovocation", "test", "with", "St", ".", "John", "'s", "Wort", ",", "we", "were", "able", "to", "demonstrate", "a", "decrease", "of", "the", "MED", "-", "UVB", "which", "was", "reversible", "after", "withdrawal", "of", "the", "medication", "." ]	[ "umlsterm" ]
tax is a Protein, interleukin-2 is a Protein, Tax is a Protein, Tax is a Protein, interleukin-2 is a Protein, Tax is a Protein, IL-2 is a Protein, IL-2 is a Protein, Tax is a Protein, Tax is a Protein, Tax is a Protein, Tax is a Protein, Tax is a Protein	9882331_task0	Sentence: Human T-cell leukemia virus type 1 tax protein abrogates interleukin-2 dependence in a mouse T-cell line. Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia. Tax, the viral protein, is thought to be crucial in the development of the disease, since it transforms healthy T cells in vitro and induces tumors in transgenic animals. We examined the effect of Tax activity on the growth of the interleukin-2 (IL-2)-dependent T-cell line CTLL-2. Stable expression of Tax in CTLL-2 transformed cell growth from being IL-2 dependent to IL-2 independent. Tax stimulated transcription through NF-kappaB and the cyclic AMP-responsive element-like sequence in the HTLV-1 promoter. The finding of Tax mutants segregating these two pathways suggested that the NF-kappaB pathway was essential for IL-2-independent growth of CTLL-2 cells while the CRE pathway was unnecessary. However, both pathways were necessary for another transformation-related activity (colony formation in soft agar) of CTLL-2/Tax. Our results show that Tax has at least two distinct activities on T cells, and suggest that Tax plays a crucial role in IL-2-independent T-cell transformation induced by HTLV-1, in addition to its well-known IL-2-dependent cell transformation. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Human T-cell leukemia virus type 1 tax protein abrogates interleukin-2 dependence in a mouse T-cell line. Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia. Tax, the viral protein, is thought to be crucial in the development of the disease, since it transforms healthy T cells in vitro and induces tumors in transgenic animals. We examined the effect of Tax activity on the growth of the interleukin-2 (IL-2)-dependent T-cell line CTLL-2. Stable expression of Tax in CTLL-2 transformed cell growth from being IL-2 dependent to IL-2 independent. Tax stimulated transcription through NF-kappaB and the cyclic AMP-responsive element-like sequence in the HTLV-1 promoter. The finding of Tax mutants segregating these two pathways suggested that the NF-kappaB pathway was essential for IL-2-independent growth of CTLL-2 cells while the CRE pathway was unnecessary. However, both pathways were necessary for another transformation-related activity (colony formation in soft agar) of CTLL-2/Tax. Our results show that Tax has at least two distinct activities on T cells, and suggest that Tax plays a crucial role in IL-2-independent T-cell transformation induced by HTLV-1, in addition to its well-known IL-2-dependent cell transformation.	[ "Human", "T", "-", "cell", "leukemia", "virus", "type", "1", "tax", "protein", "abrogates", "interleukin-2", "dependence", "in", "a", "mouse", "T", "-", "cell", "line", ".", "\n", "Human", "T", "-", "cell", "leukemia", "virus", "type", "1", "(", "HTLV-1", ")", "is", "the", "etiologic", "agent", "of", "adult", "T", "-", "cell", "leukemia", ".", "Tax", ",", "the", "viral", "protein", ",", "is", "thought", "to", "be", "crucial", "in", "the", "development", "of", "the", "disease", ",", "since", "it", "transforms", "healthy", "T", "cells", "in", "vitro", "and", "induces", "tumors", "in", "transgenic", "animals", ".", "We", "examined", "the", "effect", "of", "Tax", "activity", "on", "the", "growth", "of", "the", "interleukin-2", "(", "IL-2)-dependent", "T", "-", "cell", "line", "CTLL-2", ".", "Stable", "expression", "of", "Tax", "in", "CTLL-2", "transformed", "cell", "growth", "from", "being", "IL-2", "dependent", "to", "IL-2", "independent", ".", "Tax", "stimulated", "transcription", "through", "NF", "-", "kappaB", "and", "the", "cyclic", "AMP", "-", "responsive", "element", "-", "like", "sequence", "in", "the", "HTLV-1", "promoter", ".", "The", "finding", "of", "Tax", "mutants", "segregating", "these", "two", "pathways", "suggested", "that", "the", "NF", "-", "kappaB", "pathway", "was", "essential", "for", "IL-2-independent", "growth", "of", "CTLL-2", "cells", "while", "the", "CRE", "pathway", "was", "unnecessary", ".", "However", ",", "both", "pathways", "were", "necessary", "for", "another", "transformation", "-", "related", "activity", "(", "colony", "formation", "in", "soft", "agar", ")", "of", "CTLL-2", "/", "Tax", ".", "Our", "results", "show", "that", "Tax", "has", "at", "least", "two", "distinct", "activities", "on", "T", "cells", ",", "and", "suggest", "that", "Tax", "plays", "a", "crucial", "role", "in", "IL-2-independent", "T", "-", "cell", "transformation", "induced", "by", "HTLV-1", ",", "in", "addition", "to", "its", "well", "-", "known", "IL-2-dependent", "cell", "transformation", "." ]	[ "Protein" ]
tax is a Protein, interleukin-2 is a Protein, Tax is a Protein, Tax is a Protein, interleukin-2 is a Protein, Tax is a Protein, IL-2 is a Protein, IL-2 is a Protein, Tax is a Protein, Tax is a Protein, Tax is a Protein, Tax is a Protein, Tax is a Protein	9882331_task1	Sentence: Human T-cell leukemia virus type 1 tax protein abrogates interleukin-2 dependence in a mouse T-cell line. Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia. Tax, the viral protein, is thought to be crucial in the development of the disease, since it transforms healthy T cells in vitro and induces tumors in transgenic animals. We examined the effect of Tax activity on the growth of the interleukin-2 (IL-2)-dependent T-cell line CTLL-2. Stable expression of Tax in CTLL-2 transformed cell growth from being IL-2 dependent to IL-2 independent. Tax stimulated transcription through NF-kappaB and the cyclic AMP-responsive element-like sequence in the HTLV-1 promoter. The finding of Tax mutants segregating these two pathways suggested that the NF-kappaB pathway was essential for IL-2-independent growth of CTLL-2 cells while the CRE pathway was unnecessary. However, both pathways were necessary for another transformation-related activity (colony formation in soft agar) of CTLL-2/Tax. Our results show that Tax has at least two distinct activities on T cells, and suggest that Tax plays a crucial role in IL-2-independent T-cell transformation induced by HTLV-1, in addition to its well-known IL-2-dependent cell transformation. Instructions: please typing these entity words according to sentence: tax, interleukin-2, Tax, Tax, interleukin-2, Tax, IL-2, IL-2, Tax, Tax, Tax, Tax, Tax Options: Protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Human T-cell leukemia virus type 1 tax protein abrogates interleukin-2 dependence in a mouse T-cell line. Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia. Tax, the viral protein, is thought to be crucial in the development of the disease, since it transforms healthy T cells in vitro and induces tumors in transgenic animals. We examined the effect of Tax activity on the growth of the interleukin-2 (IL-2)-dependent T-cell line CTLL-2. Stable expression of Tax in CTLL-2 transformed cell growth from being IL-2 dependent to IL-2 independent. Tax stimulated transcription through NF-kappaB and the cyclic AMP-responsive element-like sequence in the HTLV-1 promoter. The finding of Tax mutants segregating these two pathways suggested that the NF-kappaB pathway was essential for IL-2-independent growth of CTLL-2 cells while the CRE pathway was unnecessary. However, both pathways were necessary for another transformation-related activity (colony formation in soft agar) of CTLL-2/Tax. Our results show that Tax has at least two distinct activities on T cells, and suggest that Tax plays a crucial role in IL-2-independent T-cell transformation induced by HTLV-1, in addition to its well-known IL-2-dependent cell transformation.	[ "Human", "T", "-", "cell", "leukemia", "virus", "type", "1", "tax", "protein", "abrogates", "interleukin-2", "dependence", "in", "a", "mouse", "T", "-", "cell", "line", ".", "\n", "Human", "T", "-", "cell", "leukemia", "virus", "type", "1", "(", "HTLV-1", ")", "is", "the", "etiologic", "agent", "of", "adult", "T", "-", "cell", "leukemia", ".", "Tax", ",", "the", "viral", "protein", ",", "is", "thought", "to", "be", "crucial", "in", "the", "development", "of", "the", "disease", ",", "since", "it", "transforms", "healthy", "T", "cells", "in", "vitro", "and", "induces", "tumors", "in", "transgenic", "animals", ".", "We", "examined", "the", "effect", "of", "Tax", "activity", "on", "the", "growth", "of", "the", "interleukin-2", "(", "IL-2)-dependent", "T", "-", "cell", "line", "CTLL-2", ".", "Stable", "expression", "of", "Tax", "in", "CTLL-2", "transformed", "cell", "growth", "from", "being", "IL-2", "dependent", "to", "IL-2", "independent", ".", "Tax", "stimulated", "transcription", "through", "NF", "-", "kappaB", "and", "the", "cyclic", "AMP", "-", "responsive", "element", "-", "like", "sequence", "in", "the", "HTLV-1", "promoter", ".", "The", "finding", "of", "Tax", "mutants", "segregating", "these", "two", "pathways", "suggested", "that", "the", "NF", "-", "kappaB", "pathway", "was", "essential", "for", "IL-2-independent", "growth", "of", "CTLL-2", "cells", "while", "the", "CRE", "pathway", "was", "unnecessary", ".", "However", ",", "both", "pathways", "were", "necessary", "for", "another", "transformation", "-", "related", "activity", "(", "colony", "formation", "in", "soft", "agar", ")", "of", "CTLL-2", "/", "Tax", ".", "Our", "results", "show", "that", "Tax", "has", "at", "least", "two", "distinct", "activities", "on", "T", "cells", ",", "and", "suggest", "that", "Tax", "plays", "a", "crucial", "role", "in", "IL-2-independent", "T", "-", "cell", "transformation", "induced", "by", "HTLV-1", ",", "in", "addition", "to", "its", "well", "-", "known", "IL-2-dependent", "cell", "transformation", "." ]	[ "Protein" ]
tax, interleukin-2, Tax, Tax, interleukin-2, Tax, IL-2, IL-2, Tax, Tax, Tax, Tax, Tax	9882331_task2	Sentence: Human T-cell leukemia virus type 1 tax protein abrogates interleukin-2 dependence in a mouse T-cell line. Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia. Tax, the viral protein, is thought to be crucial in the development of the disease, since it transforms healthy T cells in vitro and induces tumors in transgenic animals. We examined the effect of Tax activity on the growth of the interleukin-2 (IL-2)-dependent T-cell line CTLL-2. Stable expression of Tax in CTLL-2 transformed cell growth from being IL-2 dependent to IL-2 independent. Tax stimulated transcription through NF-kappaB and the cyclic AMP-responsive element-like sequence in the HTLV-1 promoter. The finding of Tax mutants segregating these two pathways suggested that the NF-kappaB pathway was essential for IL-2-independent growth of CTLL-2 cells while the CRE pathway was unnecessary. However, both pathways were necessary for another transformation-related activity (colony formation in soft agar) of CTLL-2/Tax. Our results show that Tax has at least two distinct activities on T cells, and suggest that Tax plays a crucial role in IL-2-independent T-cell transformation induced by HTLV-1, in addition to its well-known IL-2-dependent cell transformation. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Human T-cell leukemia virus type 1 tax protein abrogates interleukin-2 dependence in a mouse T-cell line. Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia. Tax, the viral protein, is thought to be crucial in the development of the disease, since it transforms healthy T cells in vitro and induces tumors in transgenic animals. We examined the effect of Tax activity on the growth of the interleukin-2 (IL-2)-dependent T-cell line CTLL-2. Stable expression of Tax in CTLL-2 transformed cell growth from being IL-2 dependent to IL-2 independent. Tax stimulated transcription through NF-kappaB and the cyclic AMP-responsive element-like sequence in the HTLV-1 promoter. The finding of Tax mutants segregating these two pathways suggested that the NF-kappaB pathway was essential for IL-2-independent growth of CTLL-2 cells while the CRE pathway was unnecessary. However, both pathways were necessary for another transformation-related activity (colony formation in soft agar) of CTLL-2/Tax. Our results show that Tax has at least two distinct activities on T cells, and suggest that Tax plays a crucial role in IL-2-independent T-cell transformation induced by HTLV-1, in addition to its well-known IL-2-dependent cell transformation.	[ "Human", "T", "-", "cell", "leukemia", "virus", "type", "1", "tax", "protein", "abrogates", "interleukin-2", "dependence", "in", "a", "mouse", "T", "-", "cell", "line", ".", "\n", "Human", "T", "-", "cell", "leukemia", "virus", "type", "1", "(", "HTLV-1", ")", "is", "the", "etiologic", "agent", "of", "adult", "T", "-", "cell", "leukemia", ".", "Tax", ",", "the", "viral", "protein", ",", "is", "thought", "to", "be", "crucial", "in", "the", "development", "of", "the", "disease", ",", "since", "it", "transforms", "healthy", "T", "cells", "in", "vitro", "and", "induces", "tumors", "in", "transgenic", "animals", ".", "We", "examined", "the", "effect", "of", "Tax", "activity", "on", "the", "growth", "of", "the", "interleukin-2", "(", "IL-2)-dependent", "T", "-", "cell", "line", "CTLL-2", ".", "Stable", "expression", "of", "Tax", "in", "CTLL-2", "transformed", "cell", "growth", "from", "being", "IL-2", "dependent", "to", "IL-2", "independent", ".", "Tax", "stimulated", "transcription", "through", "NF", "-", "kappaB", "and", "the", "cyclic", "AMP", "-", "responsive", "element", "-", "like", "sequence", "in", "the", "HTLV-1", "promoter", ".", "The", "finding", "of", "Tax", "mutants", "segregating", "these", "two", "pathways", "suggested", "that", "the", "NF", "-", "kappaB", "pathway", "was", "essential", "for", "IL-2-independent", "growth", "of", "CTLL-2", "cells", "while", "the", "CRE", "pathway", "was", "unnecessary", ".", "However", ",", "both", "pathways", "were", "necessary", "for", "another", "transformation", "-", "related", "activity", "(", "colony", "formation", "in", "soft", "agar", ")", "of", "CTLL-2", "/", "Tax", ".", "Our", "results", "show", "that", "Tax", "has", "at", "least", "two", "distinct", "activities", "on", "T", "cells", ",", "and", "suggest", "that", "Tax", "plays", "a", "crucial", "role", "in", "IL-2-independent", "T", "-", "cell", "transformation", "induced", "by", "HTLV-1", ",", "in", "addition", "to", "its", "well", "-", "known", "IL-2-dependent", "cell", "transformation", "." ]	[ "Protein" ]
syndrome is an umlsterm, proven is an umlsterm, wrist is an umlsterm, pain is an umlsterm, Ulna - shortening is an umlsterm, osteotomy is an umlsterm, therapy is an umlsterm, congenital is an umlsterm, radius fracture is an umlsterm, radius is an umlsterm, congenital is an umlsterm, debridement is an umlsterm, Disorders is an umlsterm, joint is an umlsterm, osteotomy is an umlsterm, treatment is an umlsterm	DerUnfallchirurg.01030197.eng.abstr_task0	Sentence: The ulnar impaction syndrome is proven to be a common source of ulnar sided wrist pain . Ulna-shortening osteotomy represents a successful therapy for this kind of problem , both congenital or posttraumatic positive ulnar variance . Positive variance resulting from a distal radius fracture needs correct dorsal and radial angulation of the radius . In case of congenital positive variance arthroscopic debridement for decompression of the TFCC should be performed first . The adequate correction of the length is the major problem . Disorders of the distal radioulnar joint may result due to overcorrection . Oblique osteotomy using 7-hole-plates is our preferred treatment . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	The ulnar impaction syndrome is proven to be a common source of ulnar sided wrist pain . Ulna-shortening osteotomy represents a successful therapy for this kind of problem , both congenital or posttraumatic positive ulnar variance . Positive variance resulting from a distal radius fracture needs correct dorsal and radial angulation of the radius . In case of congenital positive variance arthroscopic debridement for decompression of the TFCC should be performed first . The adequate correction of the length is the major problem . Disorders of the distal radioulnar joint may result due to overcorrection . Oblique osteotomy using 7-hole-plates is our preferred treatment .	[ "The", "ulnar", "impaction", "syndrome", "is", "proven", "to", "be", "a", "common", "source", "of", "ulnar", "sided", "wrist", "pain", ".", "Ulna", "-", "shortening", "osteotomy", "represents", "a", "successful", "therapy", "for", "this", "kind", "of", "problem", ",", "both", "congenital", "or", "posttraumatic", "positive", "ulnar", "variance", ".", "Positive", "variance", "resulting", "from", "a", "distal", "radius", "fracture", "needs", "correct", "dorsal", "and", "radial", "angulation", "of", "the", "radius", ".", "In", "case", "of", "congenital", "positive", "variance", "arthroscopic", "debridement", "for", "decompression", "of", "the", "TFCC", "should", "be", "performed", "first", ".", "The", "adequate", "correction", "of", "the", "length", "is", "the", "major", "problem", ".", "Disorders", "of", "the", "distal", "radioulnar", "joint", "may", "result", "due", "to", "overcorrection", ".", "Oblique", "osteotomy", "using", "7-hole", "-", "plates", "is", "our", "preferred", "treatment", "." ]	[ "umlsterm" ]
syndrome is an umlsterm, proven is an umlsterm, wrist is an umlsterm, pain is an umlsterm, Ulna - shortening is an umlsterm, osteotomy is an umlsterm, therapy is an umlsterm, congenital is an umlsterm, radius fracture is an umlsterm, radius is an umlsterm, congenital is an umlsterm, debridement is an umlsterm, Disorders is an umlsterm, joint is an umlsterm, osteotomy is an umlsterm, treatment is an umlsterm	DerUnfallchirurg.01030197.eng.abstr_task1	Sentence: The ulnar impaction syndrome is proven to be a common source of ulnar sided wrist pain . Ulna-shortening osteotomy represents a successful therapy for this kind of problem , both congenital or posttraumatic positive ulnar variance . Positive variance resulting from a distal radius fracture needs correct dorsal and radial angulation of the radius . In case of congenital positive variance arthroscopic debridement for decompression of the TFCC should be performed first . The adequate correction of the length is the major problem . Disorders of the distal radioulnar joint may result due to overcorrection . Oblique osteotomy using 7-hole-plates is our preferred treatment . Instructions: please typing these entity words according to sentence: syndrome, proven, wrist, pain, Ulna - shortening, osteotomy, therapy, congenital, radius fracture, radius, congenital, debridement, Disorders, joint, osteotomy, treatment Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	The ulnar impaction syndrome is proven to be a common source of ulnar sided wrist pain . Ulna-shortening osteotomy represents a successful therapy for this kind of problem , both congenital or posttraumatic positive ulnar variance . Positive variance resulting from a distal radius fracture needs correct dorsal and radial angulation of the radius . In case of congenital positive variance arthroscopic debridement for decompression of the TFCC should be performed first . The adequate correction of the length is the major problem . Disorders of the distal radioulnar joint may result due to overcorrection . Oblique osteotomy using 7-hole-plates is our preferred treatment .	[ "The", "ulnar", "impaction", "syndrome", "is", "proven", "to", "be", "a", "common", "source", "of", "ulnar", "sided", "wrist", "pain", ".", "Ulna", "-", "shortening", "osteotomy", "represents", "a", "successful", "therapy", "for", "this", "kind", "of", "problem", ",", "both", "congenital", "or", "posttraumatic", "positive", "ulnar", "variance", ".", "Positive", "variance", "resulting", "from", "a", "distal", "radius", "fracture", "needs", "correct", "dorsal", "and", "radial", "angulation", "of", "the", "radius", ".", "In", "case", "of", "congenital", "positive", "variance", "arthroscopic", "debridement", "for", "decompression", "of", "the", "TFCC", "should", "be", "performed", "first", ".", "The", "adequate", "correction", "of", "the", "length", "is", "the", "major", "problem", ".", "Disorders", "of", "the", "distal", "radioulnar", "joint", "may", "result", "due", "to", "overcorrection", ".", "Oblique", "osteotomy", "using", "7-hole", "-", "plates", "is", "our", "preferred", "treatment", "." ]	[ "umlsterm" ]
syndrome, proven, wrist, pain, Ulna - shortening, osteotomy, therapy, congenital, radius fracture, radius, congenital, debridement, Disorders, joint, osteotomy, treatment	DerUnfallchirurg.01030197.eng.abstr_task2	Sentence: The ulnar impaction syndrome is proven to be a common source of ulnar sided wrist pain . Ulna-shortening osteotomy represents a successful therapy for this kind of problem , both congenital or posttraumatic positive ulnar variance . Positive variance resulting from a distal radius fracture needs correct dorsal and radial angulation of the radius . In case of congenital positive variance arthroscopic debridement for decompression of the TFCC should be performed first . The adequate correction of the length is the major problem . Disorders of the distal radioulnar joint may result due to overcorrection . Oblique osteotomy using 7-hole-plates is our preferred treatment . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	The ulnar impaction syndrome is proven to be a common source of ulnar sided wrist pain . Ulna-shortening osteotomy represents a successful therapy for this kind of problem , both congenital or posttraumatic positive ulnar variance . Positive variance resulting from a distal radius fracture needs correct dorsal and radial angulation of the radius . In case of congenital positive variance arthroscopic debridement for decompression of the TFCC should be performed first . The adequate correction of the length is the major problem . Disorders of the distal radioulnar joint may result due to overcorrection . Oblique osteotomy using 7-hole-plates is our preferred treatment .	[ "The", "ulnar", "impaction", "syndrome", "is", "proven", "to", "be", "a", "common", "source", "of", "ulnar", "sided", "wrist", "pain", ".", "Ulna", "-", "shortening", "osteotomy", "represents", "a", "successful", "therapy", "for", "this", "kind", "of", "problem", ",", "both", "congenital", "or", "posttraumatic", "positive", "ulnar", "variance", ".", "Positive", "variance", "resulting", "from", "a", "distal", "radius", "fracture", "needs", "correct", "dorsal", "and", "radial", "angulation", "of", "the", "radius", ".", "In", "case", "of", "congenital", "positive", "variance", "arthroscopic", "debridement", "for", "decompression", "of", "the", "TFCC", "should", "be", "performed", "first", ".", "The", "adequate", "correction", "of", "the", "length", "is", "the", "major", "problem", ".", "Disorders", "of", "the", "distal", "radioulnar", "joint", "may", "result", "due", "to", "overcorrection", ".", "Oblique", "osteotomy", "using", "7-hole", "-", "plates", "is", "our", "preferred", "treatment", "." ]	[ "umlsterm" ]
N - methyl - D - aspartate receptors is a GENE-N, fibronectin is a GENE-Y	17662248_task0	Sentence: Stimulation of N-methyl-D-aspartate receptors modulates Jurkat T cell growth and adhesion to fibronectin. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, GENE-N	[ "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O" ]	Stimulation of N-methyl-D-aspartate receptors modulates Jurkat T cell growth and adhesion to fibronectin.	[ "Stimulation", "of", "N", "-", "methyl", "-", "D", "-", "aspartate", "receptors", "modulates", "Jurkat", "T", "cell", "growth", "and", "adhesion", "to", "fibronectin", "." ]	[ "CHEMICAL", "GENE-N", "GENE-Y" ]
N - methyl - D - aspartate receptors is a GENE-N, fibronectin is a GENE-Y	17662248_task1	Sentence: Stimulation of N-methyl-D-aspartate receptors modulates Jurkat T cell growth and adhesion to fibronectin. Instructions: please typing these entity words according to sentence: N - methyl - D - aspartate receptors, fibronectin Options: GENE-Y, GENE-N	[ "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O" ]	Stimulation of N-methyl-D-aspartate receptors modulates Jurkat T cell growth and adhesion to fibronectin.	[ "Stimulation", "of", "N", "-", "methyl", "-", "D", "-", "aspartate", "receptors", "modulates", "Jurkat", "T", "cell", "growth", "and", "adhesion", "to", "fibronectin", "." ]	[ "CHEMICAL", "GENE-N", "GENE-Y" ]

Glaukompatienten is an umlsterm, Tomographie is an umlsterm, Nervenfaserschicht is an umlsterm, Methoden is an umlsterm, Nervenfaserfotografie is an umlsterm, Gesichtsfeldbefunden is an umlsterm, Augen is an umlsterm, Patienten is an umlsterm, Offenwinkelglaukom is an umlsterm, Glaukomverdacht is an umlsterm, Nervenfaserschichtdicke is an umlsterm, Papillenpol is an umlsterm, Beurteilung is an umlsterm, Nervenfaserschicht is an umlsterm, Gesichtsfeldparametern is an umlsterm, Nervenfaserschicht is an umlsterm, Gesichtsfeldveraenderungen is an umlsterm, Nervenfaserschichtbefunde is an umlsterm, Erweiterung is an umlsterm, Pupille is an umlsterm

DerOpthalmologe.60930520.ger.abstr_task1

Sentence: Beim Glaukompatienten bestehen klinisch eindeutige Zusammenhaenge zwischen morphologischen und funktionellen Veraenderungen . Die neuen Scanning-Laser-Ophthalmoskope zur Tomographie der Papille und Polarimetrie der Nervenfaserschicht sollten gegenueber klinischen Methoden objektivere Daten und damit bessere Korrelationen ermoeglichen . In einer Querschnittsstudie wurden die Ergebnisse der konventionellen Papillen- und Nervenfaserfotografie , die Stereoplanimetrie , der Laser-Scanning-Tomographie ( TopSS und Polarimetrie ( ) Nerve Fiber Analyzer ) mit den Gesichtsfeldbefunden Octopus-Programm G 1 ) korreliert . Es wurden 157 Augen von 157 Patienten mit manifestem Offenwinkelglaukom sowie Glaukomverdacht untersucht . Von den polarimetrischen Parametern korreliert die Modulation der Nervenfaserschichtdicke ( Maximum - Minimum ) am besten mit der mittleren Sensitivitaet ( r2 = 0,23 ) . Von den tomographischen Parametern korrelierte die neuroretinale Randzone am oberen und unteren Papillenpol am besten mit der Verlustvarianz ( LV ) ( r2 = 0,20 ) . Die planimetrischen Papillenparameter sowie die klinische Beurteilung der Nervenfaserschicht korrelierten geringfuegig besser mit den Gesichtsfeldparametern als die Daten der Scanning-Laser-Tomographie oder Polarimetrie . Die Parameter der Nervenfaserschicht sind zwar schwieriger zu erfassen , korrelieren jedoch generell besser mit den diffusen Gesichtsfeldveraenderungen als die Papillenparameter . Die neuen Scanning-Laser-Verfahren verbessern die Korrelationen nicht , ermoeglichen jedoch eine objektive Erfassung der Papillen- und Nervenfaserschichtbefunde ohne Erweiterung der Pupille . Instructions: please typing these entity words according to sentence: Glaukompatienten, Tomographie, Nervenfaserschicht, Methoden, Nervenfaserfotografie, Gesichtsfeldbefunden, Augen, Patienten, Offenwinkelglaukom, Glaukomverdacht, Nervenfaserschichtdicke, Papillenpol, Beurteilung, Nervenfaserschicht, Gesichtsfeldparametern, Nervenfaserschicht, Gesichtsfeldveraenderungen, Nervenfaserschichtbefunde, Erweiterung, Pupille Options: umlsterm

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Beim Glaukompatienten bestehen klinisch eindeutige Zusammenhaenge zwischen morphologischen und funktionellen Veraenderungen . Die neuen Scanning-Laser-Ophthalmoskope zur Tomographie der Papille und Polarimetrie der Nervenfaserschicht sollten gegenueber klinischen Methoden objektivere Daten und damit bessere Korrelationen ermoeglichen . In einer Querschnittsstudie wurden die Ergebnisse der konventionellen Papillen- und Nervenfaserfotografie , die Stereoplanimetrie , der Laser-Scanning-Tomographie ( TopSS und Polarimetrie ( ) Nerve Fiber Analyzer ) mit den Gesichtsfeldbefunden Octopus-Programm G 1 ) korreliert . Es wurden 157 Augen von 157 Patienten mit manifestem Offenwinkelglaukom sowie Glaukomverdacht untersucht . Von den polarimetrischen Parametern korreliert die Modulation der Nervenfaserschichtdicke ( Maximum - Minimum ) am besten mit der mittleren Sensitivitaet ( r2 = 0,23 ) . Von den tomographischen Parametern korrelierte die neuroretinale Randzone am oberen und unteren Papillenpol am besten mit der Verlustvarianz ( LV ) ( r2 = 0,20 ) . Die planimetrischen Papillenparameter sowie die klinische Beurteilung der Nervenfaserschicht korrelierten geringfuegig besser mit den Gesichtsfeldparametern als die Daten der Scanning-Laser-Tomographie oder Polarimetrie . Die Parameter der Nervenfaserschicht sind zwar schwieriger zu erfassen , korrelieren jedoch generell besser mit den diffusen Gesichtsfeldveraenderungen als die Papillenparameter . Die neuen Scanning-Laser-Verfahren verbessern die Korrelationen nicht , ermoeglichen jedoch eine objektive Erfassung der Papillen- und Nervenfaserschichtbefunde ohne Erweiterung der Pupille .

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[ "umlsterm" ]

Glaukompatienten, Tomographie, Nervenfaserschicht, Methoden, Nervenfaserfotografie, Gesichtsfeldbefunden, Augen, Patienten, Offenwinkelglaukom, Glaukomverdacht, Nervenfaserschichtdicke, Papillenpol, Beurteilung, Nervenfaserschicht, Gesichtsfeldparametern, Nervenfaserschicht, Gesichtsfeldveraenderungen, Nervenfaserschichtbefunde, Erweiterung, Pupille

DerOpthalmologe.60930520.ger.abstr_task2

Sentence: Beim Glaukompatienten bestehen klinisch eindeutige Zusammenhaenge zwischen morphologischen und funktionellen Veraenderungen . Die neuen Scanning-Laser-Ophthalmoskope zur Tomographie der Papille und Polarimetrie der Nervenfaserschicht sollten gegenueber klinischen Methoden objektivere Daten und damit bessere Korrelationen ermoeglichen . In einer Querschnittsstudie wurden die Ergebnisse der konventionellen Papillen- und Nervenfaserfotografie , die Stereoplanimetrie , der Laser-Scanning-Tomographie ( TopSS und Polarimetrie ( ) Nerve Fiber Analyzer ) mit den Gesichtsfeldbefunden Octopus-Programm G 1 ) korreliert . Es wurden 157 Augen von 157 Patienten mit manifestem Offenwinkelglaukom sowie Glaukomverdacht untersucht . Von den polarimetrischen Parametern korreliert die Modulation der Nervenfaserschichtdicke ( Maximum - Minimum ) am besten mit der mittleren Sensitivitaet ( r2 = 0,23 ) . Von den tomographischen Parametern korrelierte die neuroretinale Randzone am oberen und unteren Papillenpol am besten mit der Verlustvarianz ( LV ) ( r2 = 0,20 ) . Die planimetrischen Papillenparameter sowie die klinische Beurteilung der Nervenfaserschicht korrelierten geringfuegig besser mit den Gesichtsfeldparametern als die Daten der Scanning-Laser-Tomographie oder Polarimetrie . Die Parameter der Nervenfaserschicht sind zwar schwieriger zu erfassen , korrelieren jedoch generell besser mit den diffusen Gesichtsfeldveraenderungen als die Papillenparameter . Die neuen Scanning-Laser-Verfahren verbessern die Korrelationen nicht , ermoeglichen jedoch eine objektive Erfassung der Papillen- und Nervenfaserschichtbefunde ohne Erweiterung der Pupille . Instructions: please extract entity words from the input sentence

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Beim Glaukompatienten bestehen klinisch eindeutige Zusammenhaenge zwischen morphologischen und funktionellen Veraenderungen . Die neuen Scanning-Laser-Ophthalmoskope zur Tomographie der Papille und Polarimetrie der Nervenfaserschicht sollten gegenueber klinischen Methoden objektivere Daten und damit bessere Korrelationen ermoeglichen . In einer Querschnittsstudie wurden die Ergebnisse der konventionellen Papillen- und Nervenfaserfotografie , die Stereoplanimetrie , der Laser-Scanning-Tomographie ( TopSS und Polarimetrie ( ) Nerve Fiber Analyzer ) mit den Gesichtsfeldbefunden Octopus-Programm G 1 ) korreliert . Es wurden 157 Augen von 157 Patienten mit manifestem Offenwinkelglaukom sowie Glaukomverdacht untersucht . Von den polarimetrischen Parametern korreliert die Modulation der Nervenfaserschichtdicke ( Maximum - Minimum ) am besten mit der mittleren Sensitivitaet ( r2 = 0,23 ) . Von den tomographischen Parametern korrelierte die neuroretinale Randzone am oberen und unteren Papillenpol am besten mit der Verlustvarianz ( LV ) ( r2 = 0,20 ) . Die planimetrischen Papillenparameter sowie die klinische Beurteilung der Nervenfaserschicht korrelierten geringfuegig besser mit den Gesichtsfeldparametern als die Daten der Scanning-Laser-Tomographie oder Polarimetrie . Die Parameter der Nervenfaserschicht sind zwar schwieriger zu erfassen , korrelieren jedoch generell besser mit den diffusen Gesichtsfeldveraenderungen als die Papillenparameter . Die neuen Scanning-Laser-Verfahren verbessern die Korrelationen nicht , ermoeglichen jedoch eine objektive Erfassung der Papillen- und Nervenfaserschichtbefunde ohne Erweiterung der Pupille .

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[ "umlsterm" ]

liver abscess is an umlsterm, disease is an umlsterm, man is an umlsterm, liver abscess is an umlsterm, pleural empyema is an umlsterm, trauma is an umlsterm, patient is an umlsterm, therapy is an umlsterm, hepatectomy is an umlsterm, pleural is an umlsterm, drainage is an umlsterm, signs is an umlsterm, diagnosis is an umlsterm, therapy is an umlsterm, case report is an umlsterm

DerChirurg.80690985.eng.abstr_task0

Sentence: Post-traumatic pyogenic liver abscess is a rare disease . We present the case of a 38-year-old man with multilocular liver abscess and pleural empyema following blunt abdominal trauma . The patient had a prodrome lasting 3 months before presenting in our department . The therapy included partial hepatectomy and pleural drainage . Clinical signs , diagnosis and possible therapy are discussed in this case report . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]

Post-traumatic pyogenic liver abscess is a rare disease . We present the case of a 38-year-old man with multilocular liver abscess and pleural empyema following blunt abdominal trauma . The patient had a prodrome lasting 3 months before presenting in our department . The therapy included partial hepatectomy and pleural drainage . Clinical signs , diagnosis and possible therapy are discussed in this case report .

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[ "umlsterm" ]

liver abscess is an umlsterm, disease is an umlsterm, man is an umlsterm, liver abscess is an umlsterm, pleural empyema is an umlsterm, trauma is an umlsterm, patient is an umlsterm, therapy is an umlsterm, hepatectomy is an umlsterm, pleural is an umlsterm, drainage is an umlsterm, signs is an umlsterm, diagnosis is an umlsterm, therapy is an umlsterm, case report is an umlsterm

DerChirurg.80690985.eng.abstr_task1

Sentence: Post-traumatic pyogenic liver abscess is a rare disease . We present the case of a 38-year-old man with multilocular liver abscess and pleural empyema following blunt abdominal trauma . The patient had a prodrome lasting 3 months before presenting in our department . The therapy included partial hepatectomy and pleural drainage . Clinical signs , diagnosis and possible therapy are discussed in this case report . Instructions: please typing these entity words according to sentence: liver abscess, disease, man, liver abscess, pleural empyema, trauma, patient, therapy, hepatectomy, pleural, drainage, signs, diagnosis, therapy, case report Options: umlsterm

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Post-traumatic pyogenic liver abscess is a rare disease . We present the case of a 38-year-old man with multilocular liver abscess and pleural empyema following blunt abdominal trauma . The patient had a prodrome lasting 3 months before presenting in our department . The therapy included partial hepatectomy and pleural drainage . Clinical signs , diagnosis and possible therapy are discussed in this case report .

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[ "umlsterm" ]

liver abscess, disease, man, liver abscess, pleural empyema, trauma, patient, therapy, hepatectomy, pleural, drainage, signs, diagnosis, therapy, case report

DerChirurg.80690985.eng.abstr_task2

Sentence: Post-traumatic pyogenic liver abscess is a rare disease . We present the case of a 38-year-old man with multilocular liver abscess and pleural empyema following blunt abdominal trauma . The patient had a prodrome lasting 3 months before presenting in our department . The therapy included partial hepatectomy and pleural drainage . Clinical signs , diagnosis and possible therapy are discussed in this case report . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]

Post-traumatic pyogenic liver abscess is a rare disease . We present the case of a 38-year-old man with multilocular liver abscess and pleural empyema following blunt abdominal trauma . The patient had a prodrome lasting 3 months before presenting in our department . The therapy included partial hepatectomy and pleural drainage . Clinical signs , diagnosis and possible therapy are discussed in this case report .

[ "Post", "-", "traumatic", "pyogenic", "liver", "abscess", "is", "a", "rare", "disease", ".", "We", "present", "the", "case", "of", "a", "38-year", "-", "old", "man", "with", "multilocular", "liver", "abscess", "and", "pleural", "empyema", "following", "blunt", "abdominal", "trauma", ".", "The", "patient", "had", "a", "prodrome", "lasting", "3", "months", "before", "presenting", "in", "our", "department", ".", "The", "therapy", "included", "partial", "hepatectomy", "and", "pleural", "drainage", ".", "Clinical", "signs", ",", "diagnosis", "and", "possible", "therapy", "are", "discussed", "in", "this", "case", "report", "." ]

[ "umlsterm" ]

use is an umlsterm, propofol is an umlsterm, hypnosis is an umlsterm, children is an umlsterm, elder is an umlsterm, data reported is an umlsterm, literature is an umlsterm, pharmacokinetic is an umlsterm, propofol is an umlsterm, children is an umlsterm, use is an umlsterm, narcotic is an umlsterm, hypnotic is an umlsterm, diagnostic is an umlsterm, therapeutic is an umlsterm

DerAnaesthesist.80470229.eng.abstr_task0

Sentence: Since its introduction in clinical use more than ten years ago , propofol is well appreciated for sedation and supplemental hypnosis in anaesthesia . However the substance is approved only for anaesthesia in children elder than three years . As can be substantiated by many data reported in literature , there are no pharmacokinetic or pharmacodynamic reasons whatsoever to withhold propofol from the younger children ; this applies both to the use as a narcotic supplement and as a short term hypnotic for diagnostic and therapeutic interventions . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O" ]

Since its introduction in clinical use more than ten years ago , propofol is well appreciated for sedation and supplemental hypnosis in anaesthesia . However the substance is approved only for anaesthesia in children elder than three years . As can be substantiated by many data reported in literature , there are no pharmacokinetic or pharmacodynamic reasons whatsoever to withhold propofol from the younger children ; this applies both to the use as a narcotic supplement and as a short term hypnotic for diagnostic and therapeutic interventions .

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[ "umlsterm" ]

use is an umlsterm, propofol is an umlsterm, hypnosis is an umlsterm, children is an umlsterm, elder is an umlsterm, data reported is an umlsterm, literature is an umlsterm, pharmacokinetic is an umlsterm, propofol is an umlsterm, children is an umlsterm, use is an umlsterm, narcotic is an umlsterm, hypnotic is an umlsterm, diagnostic is an umlsterm, therapeutic is an umlsterm

DerAnaesthesist.80470229.eng.abstr_task1

Sentence: Since its introduction in clinical use more than ten years ago , propofol is well appreciated for sedation and supplemental hypnosis in anaesthesia . However the substance is approved only for anaesthesia in children elder than three years . As can be substantiated by many data reported in literature , there are no pharmacokinetic or pharmacodynamic reasons whatsoever to withhold propofol from the younger children ; this applies both to the use as a narcotic supplement and as a short term hypnotic for diagnostic and therapeutic interventions . Instructions: please typing these entity words according to sentence: use, propofol, hypnosis, children, elder, data reported, literature, pharmacokinetic, propofol, children, use, narcotic, hypnotic, diagnostic, therapeutic Options: umlsterm

[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O" ]

Since its introduction in clinical use more than ten years ago , propofol is well appreciated for sedation and supplemental hypnosis in anaesthesia . However the substance is approved only for anaesthesia in children elder than three years . As can be substantiated by many data reported in literature , there are no pharmacokinetic or pharmacodynamic reasons whatsoever to withhold propofol from the younger children ; this applies both to the use as a narcotic supplement and as a short term hypnotic for diagnostic and therapeutic interventions .

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[ "umlsterm" ]

use, propofol, hypnosis, children, elder, data reported, literature, pharmacokinetic, propofol, children, use, narcotic, hypnotic, diagnostic, therapeutic

DerAnaesthesist.80470229.eng.abstr_task2

Sentence: Since its introduction in clinical use more than ten years ago , propofol is well appreciated for sedation and supplemental hypnosis in anaesthesia . However the substance is approved only for anaesthesia in children elder than three years . As can be substantiated by many data reported in literature , there are no pharmacokinetic or pharmacodynamic reasons whatsoever to withhold propofol from the younger children ; this applies both to the use as a narcotic supplement and as a short term hypnotic for diagnostic and therapeutic interventions . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O" ]

Since its introduction in clinical use more than ten years ago , propofol is well appreciated for sedation and supplemental hypnosis in anaesthesia . However the substance is approved only for anaesthesia in children elder than three years . As can be substantiated by many data reported in literature , there are no pharmacokinetic or pharmacodynamic reasons whatsoever to withhold propofol from the younger children ; this applies both to the use as a narcotic supplement and as a short term hypnotic for diagnostic and therapeutic interventions .

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[ "umlsterm" ]

ADF/ cofilin is a protein-family, actin is a protein-family

1.0alpha7.train.93_task0

Sentence: ADF/ cofilin can directly bind to actin filaments and promote their disassembly (Carlier et al., 1999 ; Bamburg, 1999 ). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: protein-family

[ "B-protein-family", "I-protein-family", "O", "O", "O", "O", "B-protein-family", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

ADF/ cofilin can directly bind to actin filaments and promote their disassembly (Carlier et al., 1999 ; Bamburg, 1999 ).

[ "ADF/", "cofilin", "can", "directly", "bind", "to", "actin", "filaments", "and", "promote", "their", "disassembly", "(", "Carlier", "et", "al", ".", ",", "1999", ";", "Bamburg", ",", "1999", ")", "." ]

[ "protein-family" ]

ADF/ cofilin is a protein-family, actin is a protein-family

1.0alpha7.train.93_task1

Sentence: ADF/ cofilin can directly bind to actin filaments and promote their disassembly (Carlier et al., 1999 ; Bamburg, 1999 ). Instructions: please typing these entity words according to sentence: ADF/ cofilin, actin Options: protein-family

[ "B-protein-family", "I-protein-family", "O", "O", "O", "O", "B-protein-family", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

ADF/ cofilin can directly bind to actin filaments and promote their disassembly (Carlier et al., 1999 ; Bamburg, 1999 ).

[ "ADF/", "cofilin", "can", "directly", "bind", "to", "actin", "filaments", "and", "promote", "their", "disassembly", "(", "Carlier", "et", "al", ".", ",", "1999", ";", "Bamburg", ",", "1999", ")", "." ]

[ "protein-family" ]

ADF/ cofilin, actin

1.0alpha7.train.93_task2

Sentence: ADF/ cofilin can directly bind to actin filaments and promote their disassembly (Carlier et al., 1999 ; Bamburg, 1999 ). Instructions: please extract entity words from the input sentence

[ "B-protein-family", "I-protein-family", "O", "O", "O", "O", "B-protein-family", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

ADF/ cofilin can directly bind to actin filaments and promote their disassembly (Carlier et al., 1999 ; Bamburg, 1999 ).

[ "ADF/", "cofilin", "can", "directly", "bind", "to", "actin", "filaments", "and", "promote", "their", "disassembly", "(", "Carlier", "et", "al", ".", ",", "1999", ";", "Bamburg", ",", "1999", ")", "." ]

[ "protein-family" ]

time is an umlsterm, chorea is an umlsterm, tics is an umlsterm, syndrome is an umlsterm, Tics is an umlsterm, symptoms is an umlsterm, chorea is an umlsterm, symptoms is an umlsterm, children is an umlsterm, symptoms is an umlsterm, signs is an umlsterm, treatment is an umlsterm, diagnostic is an umlsterm, criteria is an umlsterm, susceptibility is an umlsterm, antibody is an umlsterm, antigens is an umlsterm, immunoglobulins is an umlsterm, therapy is an umlsterm, motor tics is an umlsterm, vocal tics is an umlsterm, behavioral symptoms is an umlsterm, control is an umlsterm, findings is an umlsterm, therapy is an umlsterm, literature is an umlsterm

DerNervenarzt.70680914.eng.abstr_task0

Sentence: It has known for a long time that Sydenham's chorea and tics , as seen in Gilles de la Tourette's syndrome ( GTS ) , are phenomenologically very similar . Tics may occur as symptoms of acute Sydenham's chorea or persist over years as residual symptoms . Investigations of children suffering from GTS , including obsessive-compusilve symptoms , have provided signs of a poststreptococcal autoimmune process but also shown that treatment based on immunological interventions has been effective . We treated a 14-year-old boy showing all diagnostic criteria of GTS , familial susceptibility , and an increase in the antibody titer of streptococcal antigens with 7S immunoglobulins i.v. over 5 days . Response to this therapy was good regarding motor tics , vocal tics , and behavioral symptoms such as disturbed impulse control which still persisted after 9 months . These findings and the successful therapy underline reports of the literature and point to a pathogenetic mechanism of an immunologically triggered disturbance of the striatal dopaminergic system , at least in a subgroup of GTS . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

It has known for a long time that Sydenham's chorea and tics , as seen in Gilles de la Tourette's syndrome ( GTS ) , are phenomenologically very similar . Tics may occur as symptoms of acute Sydenham's chorea or persist over years as residual symptoms . Investigations of children suffering from GTS , including obsessive-compusilve symptoms , have provided signs of a poststreptococcal autoimmune process but also shown that treatment based on immunological interventions has been effective . We treated a 14-year-old boy showing all diagnostic criteria of GTS , familial susceptibility , and an increase in the antibody titer of streptococcal antigens with 7S immunoglobulins i.v. over 5 days . Response to this therapy was good regarding motor tics , vocal tics , and behavioral symptoms such as disturbed impulse control which still persisted after 9 months . These findings and the successful therapy underline reports of the literature and point to a pathogenetic mechanism of an immunologically triggered disturbance of the striatal dopaminergic system , at least in a subgroup of GTS .

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[ "umlsterm" ]

time is an umlsterm, chorea is an umlsterm, tics is an umlsterm, syndrome is an umlsterm, Tics is an umlsterm, symptoms is an umlsterm, chorea is an umlsterm, symptoms is an umlsterm, children is an umlsterm, symptoms is an umlsterm, signs is an umlsterm, treatment is an umlsterm, diagnostic is an umlsterm, criteria is an umlsterm, susceptibility is an umlsterm, antibody is an umlsterm, antigens is an umlsterm, immunoglobulins is an umlsterm, therapy is an umlsterm, motor tics is an umlsterm, vocal tics is an umlsterm, behavioral symptoms is an umlsterm, control is an umlsterm, findings is an umlsterm, therapy is an umlsterm, literature is an umlsterm

DerNervenarzt.70680914.eng.abstr_task1

Sentence: It has known for a long time that Sydenham's chorea and tics , as seen in Gilles de la Tourette's syndrome ( GTS ) , are phenomenologically very similar . Tics may occur as symptoms of acute Sydenham's chorea or persist over years as residual symptoms . Investigations of children suffering from GTS , including obsessive-compusilve symptoms , have provided signs of a poststreptococcal autoimmune process but also shown that treatment based on immunological interventions has been effective . We treated a 14-year-old boy showing all diagnostic criteria of GTS , familial susceptibility , and an increase in the antibody titer of streptococcal antigens with 7S immunoglobulins i.v. over 5 days . Response to this therapy was good regarding motor tics , vocal tics , and behavioral symptoms such as disturbed impulse control which still persisted after 9 months . These findings and the successful therapy underline reports of the literature and point to a pathogenetic mechanism of an immunologically triggered disturbance of the striatal dopaminergic system , at least in a subgroup of GTS . Instructions: please typing these entity words according to sentence: time, chorea, tics, syndrome, Tics, symptoms, chorea, symptoms, children, symptoms, signs, treatment, diagnostic, criteria, susceptibility, antibody, antigens, immunoglobulins, therapy, motor tics, vocal tics, behavioral symptoms, control, findings, therapy, literature Options: umlsterm

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It has known for a long time that Sydenham's chorea and tics , as seen in Gilles de la Tourette's syndrome ( GTS ) , are phenomenologically very similar . Tics may occur as symptoms of acute Sydenham's chorea or persist over years as residual symptoms . Investigations of children suffering from GTS , including obsessive-compusilve symptoms , have provided signs of a poststreptococcal autoimmune process but also shown that treatment based on immunological interventions has been effective . We treated a 14-year-old boy showing all diagnostic criteria of GTS , familial susceptibility , and an increase in the antibody titer of streptococcal antigens with 7S immunoglobulins i.v. over 5 days . Response to this therapy was good regarding motor tics , vocal tics , and behavioral symptoms such as disturbed impulse control which still persisted after 9 months . These findings and the successful therapy underline reports of the literature and point to a pathogenetic mechanism of an immunologically triggered disturbance of the striatal dopaminergic system , at least in a subgroup of GTS .

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[ "umlsterm" ]

time, chorea, tics, syndrome, Tics, symptoms, chorea, symptoms, children, symptoms, signs, treatment, diagnostic, criteria, susceptibility, antibody, antigens, immunoglobulins, therapy, motor tics, vocal tics, behavioral symptoms, control, findings, therapy, literature

DerNervenarzt.70680914.eng.abstr_task2

Sentence: It has known for a long time that Sydenham's chorea and tics , as seen in Gilles de la Tourette's syndrome ( GTS ) , are phenomenologically very similar . Tics may occur as symptoms of acute Sydenham's chorea or persist over years as residual symptoms . Investigations of children suffering from GTS , including obsessive-compusilve symptoms , have provided signs of a poststreptococcal autoimmune process but also shown that treatment based on immunological interventions has been effective . We treated a 14-year-old boy showing all diagnostic criteria of GTS , familial susceptibility , and an increase in the antibody titer of streptococcal antigens with 7S immunoglobulins i.v. over 5 days . Response to this therapy was good regarding motor tics , vocal tics , and behavioral symptoms such as disturbed impulse control which still persisted after 9 months . These findings and the successful therapy underline reports of the literature and point to a pathogenetic mechanism of an immunologically triggered disturbance of the striatal dopaminergic system , at least in a subgroup of GTS . Instructions: please extract entity words from the input sentence

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It has known for a long time that Sydenham's chorea and tics , as seen in Gilles de la Tourette's syndrome ( GTS ) , are phenomenologically very similar . Tics may occur as symptoms of acute Sydenham's chorea or persist over years as residual symptoms . Investigations of children suffering from GTS , including obsessive-compusilve symptoms , have provided signs of a poststreptococcal autoimmune process but also shown that treatment based on immunological interventions has been effective . We treated a 14-year-old boy showing all diagnostic criteria of GTS , familial susceptibility , and an increase in the antibody titer of streptococcal antigens with 7S immunoglobulins i.v. over 5 days . Response to this therapy was good regarding motor tics , vocal tics , and behavioral symptoms such as disturbed impulse control which still persisted after 9 months . These findings and the successful therapy underline reports of the literature and point to a pathogenetic mechanism of an immunologically triggered disturbance of the striatal dopaminergic system , at least in a subgroup of GTS .

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[ "umlsterm" ]

PLA2G6 is a Protein, PLA2G6 is a Protein, calcium - independent phospholipase A2 is a Protein, iPLA(2)beta is a Protein, iPLA(2)beta is a Protein, PLA2G6 is a Protein, iPLA(2)beta is a Protein, ubiquitin is a Protein, ubiquitin is a Protein, iPLA(2)beta is a Protein, iPLA(2)beta is a Protein

296_task0

Sentence: Disrupted membrane homeostasis and accumulation of ubiquitinated proteins in a mouse model of infantile neuroaxonal dystrophy caused by PLA2G6 mutations. Mutations in the PLA2G6 gene, which encodes group VIA calcium-independent phospholipase A2 (iPLA(2)beta), were recently identified in patients with infantile neuroaxonal dystrophy (INAD) and neurodegeneration with brain iron accumulation. A pathological hallmark of these childhood neurodegenerative diseases is the presence of distinctive spheroids in distal axons that contain accumulated membranes. We used iPLA(2)beta-KO mice generated by homologous recombination to investigate neurodegenerative consequences of PLA2G6 mutations. iPLA(2)beta-KO mice developed age-dependent neurological impairment that was evident in rotarod, balance, and climbing tests by 13 months of age. The primary abnormality underlying this neurological impairment was the formation of spheroids containing tubulovesicular membranes remarkably similar to human INAD. Spheroids were strongly labeled with anti-ubiquitin antibodies. Accumulation of ubiquitinated protein in spheroids was evident in some brain regions as early as 4 months of age, and the onset of motor impairment correlated with a dramatic increase in ubiquitin-positive spheroids throughout the neuropil in nearly all brain regions. Furthermore accumulating ubiquitinated proteins were observed primarily in insoluble fractions of brain tissue, implicating protein aggregation in this pathogenic process. These results indicate that loss of iPLA(2)beta causes age-dependent impairment of axonal membrane homeostasis and protein degradation pathways, leading to age-dependent neurological impairment. iPLA(2)beta-KO mice will be useful for further studies of pathogenesis and experimental interventions in INAD and neurodegeneration with brain iron accumulation. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein

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Disrupted membrane homeostasis and accumulation of ubiquitinated proteins in a mouse model of infantile neuroaxonal dystrophy caused by PLA2G6 mutations. Mutations in the PLA2G6 gene, which encodes group VIA calcium-independent phospholipase A2 (iPLA(2)beta), were recently identified in patients with infantile neuroaxonal dystrophy (INAD) and neurodegeneration with brain iron accumulation. A pathological hallmark of these childhood neurodegenerative diseases is the presence of distinctive spheroids in distal axons that contain accumulated membranes. We used iPLA(2)beta-KO mice generated by homologous recombination to investigate neurodegenerative consequences of PLA2G6 mutations. iPLA(2)beta-KO mice developed age-dependent neurological impairment that was evident in rotarod, balance, and climbing tests by 13 months of age. The primary abnormality underlying this neurological impairment was the formation of spheroids containing tubulovesicular membranes remarkably similar to human INAD. Spheroids were strongly labeled with anti-ubiquitin antibodies. Accumulation of ubiquitinated protein in spheroids was evident in some brain regions as early as 4 months of age, and the onset of motor impairment correlated with a dramatic increase in ubiquitin-positive spheroids throughout the neuropil in nearly all brain regions. Furthermore accumulating ubiquitinated proteins were observed primarily in insoluble fractions of brain tissue, implicating protein aggregation in this pathogenic process. These results indicate that loss of iPLA(2)beta causes age-dependent impairment of axonal membrane homeostasis and protein degradation pathways, leading to age-dependent neurological impairment. iPLA(2)beta-KO mice will be useful for further studies of pathogenesis and experimental interventions in INAD and neurodegeneration with brain iron accumulation.

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[ "Protein" ]

PLA2G6 is a Protein, PLA2G6 is a Protein, calcium - independent phospholipase A2 is a Protein, iPLA(2)beta is a Protein, iPLA(2)beta is a Protein, PLA2G6 is a Protein, iPLA(2)beta is a Protein, ubiquitin is a Protein, ubiquitin is a Protein, iPLA(2)beta is a Protein, iPLA(2)beta is a Protein

296_task1

Sentence: Disrupted membrane homeostasis and accumulation of ubiquitinated proteins in a mouse model of infantile neuroaxonal dystrophy caused by PLA2G6 mutations. Mutations in the PLA2G6 gene, which encodes group VIA calcium-independent phospholipase A2 (iPLA(2)beta), were recently identified in patients with infantile neuroaxonal dystrophy (INAD) and neurodegeneration with brain iron accumulation. A pathological hallmark of these childhood neurodegenerative diseases is the presence of distinctive spheroids in distal axons that contain accumulated membranes. We used iPLA(2)beta-KO mice generated by homologous recombination to investigate neurodegenerative consequences of PLA2G6 mutations. iPLA(2)beta-KO mice developed age-dependent neurological impairment that was evident in rotarod, balance, and climbing tests by 13 months of age. The primary abnormality underlying this neurological impairment was the formation of spheroids containing tubulovesicular membranes remarkably similar to human INAD. Spheroids were strongly labeled with anti-ubiquitin antibodies. Accumulation of ubiquitinated protein in spheroids was evident in some brain regions as early as 4 months of age, and the onset of motor impairment correlated with a dramatic increase in ubiquitin-positive spheroids throughout the neuropil in nearly all brain regions. Furthermore accumulating ubiquitinated proteins were observed primarily in insoluble fractions of brain tissue, implicating protein aggregation in this pathogenic process. These results indicate that loss of iPLA(2)beta causes age-dependent impairment of axonal membrane homeostasis and protein degradation pathways, leading to age-dependent neurological impairment. iPLA(2)beta-KO mice will be useful for further studies of pathogenesis and experimental interventions in INAD and neurodegeneration with brain iron accumulation. Instructions: please typing these entity words according to sentence: PLA2G6, PLA2G6, calcium - independent phospholipase A2, iPLA(2)beta, iPLA(2)beta, PLA2G6, iPLA(2)beta, ubiquitin, ubiquitin, iPLA(2)beta, iPLA(2)beta Options: Protein

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Disrupted membrane homeostasis and accumulation of ubiquitinated proteins in a mouse model of infantile neuroaxonal dystrophy caused by PLA2G6 mutations. Mutations in the PLA2G6 gene, which encodes group VIA calcium-independent phospholipase A2 (iPLA(2)beta), were recently identified in patients with infantile neuroaxonal dystrophy (INAD) and neurodegeneration with brain iron accumulation. A pathological hallmark of these childhood neurodegenerative diseases is the presence of distinctive spheroids in distal axons that contain accumulated membranes. We used iPLA(2)beta-KO mice generated by homologous recombination to investigate neurodegenerative consequences of PLA2G6 mutations. iPLA(2)beta-KO mice developed age-dependent neurological impairment that was evident in rotarod, balance, and climbing tests by 13 months of age. The primary abnormality underlying this neurological impairment was the formation of spheroids containing tubulovesicular membranes remarkably similar to human INAD. Spheroids were strongly labeled with anti-ubiquitin antibodies. Accumulation of ubiquitinated protein in spheroids was evident in some brain regions as early as 4 months of age, and the onset of motor impairment correlated with a dramatic increase in ubiquitin-positive spheroids throughout the neuropil in nearly all brain regions. Furthermore accumulating ubiquitinated proteins were observed primarily in insoluble fractions of brain tissue, implicating protein aggregation in this pathogenic process. These results indicate that loss of iPLA(2)beta causes age-dependent impairment of axonal membrane homeostasis and protein degradation pathways, leading to age-dependent neurological impairment. iPLA(2)beta-KO mice will be useful for further studies of pathogenesis and experimental interventions in INAD and neurodegeneration with brain iron accumulation.

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[ "Protein" ]

PLA2G6, PLA2G6, calcium - independent phospholipase A2, iPLA(2)beta, iPLA(2)beta, PLA2G6, iPLA(2)beta, ubiquitin, ubiquitin, iPLA(2)beta, iPLA(2)beta

296_task2

Sentence: Disrupted membrane homeostasis and accumulation of ubiquitinated proteins in a mouse model of infantile neuroaxonal dystrophy caused by PLA2G6 mutations. Mutations in the PLA2G6 gene, which encodes group VIA calcium-independent phospholipase A2 (iPLA(2)beta), were recently identified in patients with infantile neuroaxonal dystrophy (INAD) and neurodegeneration with brain iron accumulation. A pathological hallmark of these childhood neurodegenerative diseases is the presence of distinctive spheroids in distal axons that contain accumulated membranes. We used iPLA(2)beta-KO mice generated by homologous recombination to investigate neurodegenerative consequences of PLA2G6 mutations. iPLA(2)beta-KO mice developed age-dependent neurological impairment that was evident in rotarod, balance, and climbing tests by 13 months of age. The primary abnormality underlying this neurological impairment was the formation of spheroids containing tubulovesicular membranes remarkably similar to human INAD. Spheroids were strongly labeled with anti-ubiquitin antibodies. Accumulation of ubiquitinated protein in spheroids was evident in some brain regions as early as 4 months of age, and the onset of motor impairment correlated with a dramatic increase in ubiquitin-positive spheroids throughout the neuropil in nearly all brain regions. Furthermore accumulating ubiquitinated proteins were observed primarily in insoluble fractions of brain tissue, implicating protein aggregation in this pathogenic process. These results indicate that loss of iPLA(2)beta causes age-dependent impairment of axonal membrane homeostasis and protein degradation pathways, leading to age-dependent neurological impairment. iPLA(2)beta-KO mice will be useful for further studies of pathogenesis and experimental interventions in INAD and neurodegeneration with brain iron accumulation. Instructions: please extract entity words from the input sentence

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Disrupted membrane homeostasis and accumulation of ubiquitinated proteins in a mouse model of infantile neuroaxonal dystrophy caused by PLA2G6 mutations. Mutations in the PLA2G6 gene, which encodes group VIA calcium-independent phospholipase A2 (iPLA(2)beta), were recently identified in patients with infantile neuroaxonal dystrophy (INAD) and neurodegeneration with brain iron accumulation. A pathological hallmark of these childhood neurodegenerative diseases is the presence of distinctive spheroids in distal axons that contain accumulated membranes. We used iPLA(2)beta-KO mice generated by homologous recombination to investigate neurodegenerative consequences of PLA2G6 mutations. iPLA(2)beta-KO mice developed age-dependent neurological impairment that was evident in rotarod, balance, and climbing tests by 13 months of age. The primary abnormality underlying this neurological impairment was the formation of spheroids containing tubulovesicular membranes remarkably similar to human INAD. Spheroids were strongly labeled with anti-ubiquitin antibodies. Accumulation of ubiquitinated protein in spheroids was evident in some brain regions as early as 4 months of age, and the onset of motor impairment correlated with a dramatic increase in ubiquitin-positive spheroids throughout the neuropil in nearly all brain regions. Furthermore accumulating ubiquitinated proteins were observed primarily in insoluble fractions of brain tissue, implicating protein aggregation in this pathogenic process. These results indicate that loss of iPLA(2)beta causes age-dependent impairment of axonal membrane homeostasis and protein degradation pathways, leading to age-dependent neurological impairment. iPLA(2)beta-KO mice will be useful for further studies of pathogenesis and experimental interventions in INAD and neurodegeneration with brain iron accumulation.

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[ "Protein" ]

Anxiety sensitivity is a Participant_Condition, later anxiety symptoms and syndromes is a Participant_Condition, anxiety sensitivity is a Participant_Condition, anxiety symptoms and panic is a Participant_Condition, anxiety psychopathology is a Intervention_Psychological, controlling for potential confounding factors is a Intervention_Educational, anxiety symptoms . is a Participant_Condition

35985_task0

Sentence: Anxiety sensitivity as an incremental predictor of later anxiety symptoms and syndromes . Although anxiety sensitivity ( AS ) has been shown to predict anxiety symptoms and panic , this literature is limited in regard to evaluating AS as an incremental predictor of anxiety psychopathology relative to other established risk factors including sex and negative affect . The present report prospectively evaluated whether AS was predictive of later changes in anxiety symptoms after controlling for potential confounding factors . Consistent with hypothesis , AS was found to be a significant , incremental predictor of anxiety symptoms over time , even after controlling for sex and negative affectivity . These data provide novel evidence for the unique association between AS of the development of anxiety symptoms . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Psychological, Intervention_Educational, Participant_Condition

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Anxiety sensitivity as an incremental predictor of later anxiety symptoms and syndromes . Although anxiety sensitivity ( AS ) has been shown to predict anxiety symptoms and panic , this literature is limited in regard to evaluating AS as an incremental predictor of anxiety psychopathology relative to other established risk factors including sex and negative affect . The present report prospectively evaluated whether AS was predictive of later changes in anxiety symptoms after controlling for potential confounding factors . Consistent with hypothesis , AS was found to be a significant , incremental predictor of anxiety symptoms over time , even after controlling for sex and negative affectivity . These data provide novel evidence for the unique association between AS of the development of anxiety symptoms .

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[ "Intervention_Educational", "Participant_Condition", "Intervention_Psychological", "Outcome_Mental" ]

Anxiety sensitivity is a Participant_Condition, later anxiety symptoms and syndromes is a Participant_Condition, anxiety sensitivity is a Participant_Condition, anxiety symptoms and panic is a Participant_Condition, anxiety psychopathology is a Intervention_Psychological, controlling for potential confounding factors is a Intervention_Educational, anxiety symptoms . is a Participant_Condition

35985_task1

Sentence: Anxiety sensitivity as an incremental predictor of later anxiety symptoms and syndromes . Although anxiety sensitivity ( AS ) has been shown to predict anxiety symptoms and panic , this literature is limited in regard to evaluating AS as an incremental predictor of anxiety psychopathology relative to other established risk factors including sex and negative affect . The present report prospectively evaluated whether AS was predictive of later changes in anxiety symptoms after controlling for potential confounding factors . Consistent with hypothesis , AS was found to be a significant , incremental predictor of anxiety symptoms over time , even after controlling for sex and negative affectivity . These data provide novel evidence for the unique association between AS of the development of anxiety symptoms . Instructions: please typing these entity words according to sentence: Anxiety sensitivity, later anxiety symptoms and syndromes, anxiety sensitivity, anxiety symptoms and panic, anxiety psychopathology, controlling for potential confounding factors, anxiety symptoms . Options: Intervention_Psychological, Intervention_Educational, Participant_Condition

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Anxiety sensitivity as an incremental predictor of later anxiety symptoms and syndromes . Although anxiety sensitivity ( AS ) has been shown to predict anxiety symptoms and panic , this literature is limited in regard to evaluating AS as an incremental predictor of anxiety psychopathology relative to other established risk factors including sex and negative affect . The present report prospectively evaluated whether AS was predictive of later changes in anxiety symptoms after controlling for potential confounding factors . Consistent with hypothesis , AS was found to be a significant , incremental predictor of anxiety symptoms over time , even after controlling for sex and negative affectivity . These data provide novel evidence for the unique association between AS of the development of anxiety symptoms .

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[ "Intervention_Educational", "Participant_Condition", "Intervention_Psychological", "Outcome_Mental" ]

Anxiety sensitivity, later anxiety symptoms and syndromes, anxiety sensitivity, anxiety symptoms and panic, anxiety psychopathology, controlling for potential confounding factors, anxiety symptoms .

35985_task2

Sentence: Anxiety sensitivity as an incremental predictor of later anxiety symptoms and syndromes . Although anxiety sensitivity ( AS ) has been shown to predict anxiety symptoms and panic , this literature is limited in regard to evaluating AS as an incremental predictor of anxiety psychopathology relative to other established risk factors including sex and negative affect . The present report prospectively evaluated whether AS was predictive of later changes in anxiety symptoms after controlling for potential confounding factors . Consistent with hypothesis , AS was found to be a significant , incremental predictor of anxiety symptoms over time , even after controlling for sex and negative affectivity . These data provide novel evidence for the unique association between AS of the development of anxiety symptoms . Instructions: please extract entity words from the input sentence

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Anxiety sensitivity as an incremental predictor of later anxiety symptoms and syndromes . Although anxiety sensitivity ( AS ) has been shown to predict anxiety symptoms and panic , this literature is limited in regard to evaluating AS as an incremental predictor of anxiety psychopathology relative to other established risk factors including sex and negative affect . The present report prospectively evaluated whether AS was predictive of later changes in anxiety symptoms after controlling for potential confounding factors . Consistent with hypothesis , AS was found to be a significant , incremental predictor of anxiety symptoms over time , even after controlling for sex and negative affectivity . These data provide novel evidence for the unique association between AS of the development of anxiety symptoms .

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[ "Intervention_Educational", "Participant_Condition", "Intervention_Psychological", "Outcome_Mental" ]

pain - free treadmill training is a Intervention_Physical, fibrinogen is a Outcome_Physical, claudication is a Participant_Condition, plasma fibrinogen , haematocrit , lipid profile , and walking ability is a Outcome_Physical, Sixty - eight is a Participant_Sample-size, peripheral obstructive arterial disease is a Participant_Condition, intermittent claudication is a Participant_Condition, control group is a Intervention_Control, no change in physical activity is a Intervention_Physical, pain - free walking time ( PFWT ) is a Outcome_Physical, maximal walking time ( MWT ) is a Outcome_Physical, blood analyses [ for haematocrit , fibrinogen , triglycerides , and cholesterol : total , high - density lipoprotein ( HDL ) and low - density lipoprotein ( LDL ) ] is a Outcome_Physical, Total and LDL cholesterol levels is a Outcome_Physical, HDL cholesterol is a Outcome_Physical, Haematocrit is a Outcome_Physical

49879_task0

Sentence: The effect of pain-free treadmill training on fibrinogen , haematocrit , and lipid profile in patients with claudication . OBJECTIVE To assess the effect of pain-free treadmill training on changes of plasma fibrinogen , haematocrit , lipid profile , and walking ability in patients with claudication . DESIGN Randomized control trial . METHODS Sixty-eight patients with peripheral obstructive arterial disease and intermittent claudication ( Fontaine stage II ) were randomly assigned into the treadmill training ( repetitive intervals to onset of claudication pain , three times a week ) or a control group ( no change in physical activity ) over 3 months . Both groups performed treadmill test to assess pain-free walking time ( PFWT ) and maximal walking time ( MWT ) and had blood analyses [ for haematocrit , fibrinogen , triglycerides , and cholesterol : total , high-density lipoprotein ( HDL ) and low-density lipoprotein ( LDL ) ] done at baseline and after 6 and 12 weeks of the study . RESULTS Total and LDL cholesterol levels in the training group decreased ( p < 0.05 ) by 14.8 % and 20,5 % , respectively . Significant ( p < 0.05 ) HDL cholesterol increased ( 14.6 % ) and triglycerides decreased ( 19 % ) in the training group but changes of all these lipids were insignificant in the control group over the 3 months . Haematocrit and fibrinogen changes were insignificant in both groups . PFWT was prolonged by 109 % and MWT increased by 54 % in the training group ( p < 0.01 ) , but not in the control group . CONCLUSION The improvement in walking time over 3 months of pain-free treadmill training parallels with progressive normalization of lipid profiles in patients with claudication . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Physical, Intervention_Control, Participant_Condition, Outcome_Physical, Participant_Sample-size

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The effect of pain-free treadmill training on fibrinogen , haematocrit , and lipid profile in patients with claudication . OBJECTIVE To assess the effect of pain-free treadmill training on changes of plasma fibrinogen , haematocrit , lipid profile , and walking ability in patients with claudication . DESIGN Randomized control trial . METHODS Sixty-eight patients with peripheral obstructive arterial disease and intermittent claudication ( Fontaine stage II ) were randomly assigned into the treadmill training ( repetitive intervals to onset of claudication pain , three times a week ) or a control group ( no change in physical activity ) over 3 months . Both groups performed treadmill test to assess pain-free walking time ( PFWT ) and maximal walking time ( MWT ) and had blood analyses [ for haematocrit , fibrinogen , triglycerides , and cholesterol : total , high-density lipoprotein ( HDL ) and low-density lipoprotein ( LDL ) ] done at baseline and after 6 and 12 weeks of the study . RESULTS Total and LDL cholesterol levels in the training group decreased ( p < 0.05 ) by 14.8 % and 20,5 % , respectively . Significant ( p < 0.05 ) HDL cholesterol increased ( 14.6 % ) and triglycerides decreased ( 19 % ) in the training group but changes of all these lipids were insignificant in the control group over the 3 months . Haematocrit and fibrinogen changes were insignificant in both groups . PFWT was prolonged by 109 % and MWT increased by 54 % in the training group ( p < 0.01 ) , but not in the control group . CONCLUSION The improvement in walking time over 3 months of pain-free treadmill training parallels with progressive normalization of lipid profiles in patients with claudication .

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[ "Outcome_Physical", "Participant_Condition", "Intervention_Physical", "Intervention_Control", "Participant_Sample-size" ]

pain - free treadmill training is a Intervention_Physical, fibrinogen is a Outcome_Physical, claudication is a Participant_Condition, plasma fibrinogen , haematocrit , lipid profile , and walking ability is a Outcome_Physical, Sixty - eight is a Participant_Sample-size, peripheral obstructive arterial disease is a Participant_Condition, intermittent claudication is a Participant_Condition, control group is a Intervention_Control, no change in physical activity is a Intervention_Physical, pain - free walking time ( PFWT ) is a Outcome_Physical, maximal walking time ( MWT ) is a Outcome_Physical, blood analyses [ for haematocrit , fibrinogen , triglycerides , and cholesterol : total , high - density lipoprotein ( HDL ) and low - density lipoprotein ( LDL ) ] is a Outcome_Physical, Total and LDL cholesterol levels is a Outcome_Physical, HDL cholesterol is a Outcome_Physical, Haematocrit is a Outcome_Physical

49879_task1

Sentence: The effect of pain-free treadmill training on fibrinogen , haematocrit , and lipid profile in patients with claudication . OBJECTIVE To assess the effect of pain-free treadmill training on changes of plasma fibrinogen , haematocrit , lipid profile , and walking ability in patients with claudication . DESIGN Randomized control trial . METHODS Sixty-eight patients with peripheral obstructive arterial disease and intermittent claudication ( Fontaine stage II ) were randomly assigned into the treadmill training ( repetitive intervals to onset of claudication pain , three times a week ) or a control group ( no change in physical activity ) over 3 months . Both groups performed treadmill test to assess pain-free walking time ( PFWT ) and maximal walking time ( MWT ) and had blood analyses [ for haematocrit , fibrinogen , triglycerides , and cholesterol : total , high-density lipoprotein ( HDL ) and low-density lipoprotein ( LDL ) ] done at baseline and after 6 and 12 weeks of the study . RESULTS Total and LDL cholesterol levels in the training group decreased ( p < 0.05 ) by 14.8 % and 20,5 % , respectively . Significant ( p < 0.05 ) HDL cholesterol increased ( 14.6 % ) and triglycerides decreased ( 19 % ) in the training group but changes of all these lipids were insignificant in the control group over the 3 months . Haematocrit and fibrinogen changes were insignificant in both groups . PFWT was prolonged by 109 % and MWT increased by 54 % in the training group ( p < 0.01 ) , but not in the control group . CONCLUSION The improvement in walking time over 3 months of pain-free treadmill training parallels with progressive normalization of lipid profiles in patients with claudication . Instructions: please typing these entity words according to sentence: pain - free treadmill training, fibrinogen, claudication, plasma fibrinogen , haematocrit , lipid profile , and walking ability, Sixty - eight, peripheral obstructive arterial disease, intermittent claudication, control group, no change in physical activity, pain - free walking time ( PFWT ), maximal walking time ( MWT ), blood analyses [ for haematocrit , fibrinogen , triglycerides , and cholesterol : total , high - density lipoprotein ( HDL ) and low - density lipoprotein ( LDL ) ], Total and LDL cholesterol levels, HDL cholesterol, Haematocrit Options: Intervention_Physical, Intervention_Control, Participant_Condition, Outcome_Physical, Participant_Sample-size

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The effect of pain-free treadmill training on fibrinogen , haematocrit , and lipid profile in patients with claudication . OBJECTIVE To assess the effect of pain-free treadmill training on changes of plasma fibrinogen , haematocrit , lipid profile , and walking ability in patients with claudication . DESIGN Randomized control trial . METHODS Sixty-eight patients with peripheral obstructive arterial disease and intermittent claudication ( Fontaine stage II ) were randomly assigned into the treadmill training ( repetitive intervals to onset of claudication pain , three times a week ) or a control group ( no change in physical activity ) over 3 months . Both groups performed treadmill test to assess pain-free walking time ( PFWT ) and maximal walking time ( MWT ) and had blood analyses [ for haematocrit , fibrinogen , triglycerides , and cholesterol : total , high-density lipoprotein ( HDL ) and low-density lipoprotein ( LDL ) ] done at baseline and after 6 and 12 weeks of the study . RESULTS Total and LDL cholesterol levels in the training group decreased ( p < 0.05 ) by 14.8 % and 20,5 % , respectively . Significant ( p < 0.05 ) HDL cholesterol increased ( 14.6 % ) and triglycerides decreased ( 19 % ) in the training group but changes of all these lipids were insignificant in the control group over the 3 months . Haematocrit and fibrinogen changes were insignificant in both groups . PFWT was prolonged by 109 % and MWT increased by 54 % in the training group ( p < 0.01 ) , but not in the control group . CONCLUSION The improvement in walking time over 3 months of pain-free treadmill training parallels with progressive normalization of lipid profiles in patients with claudication .

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[ "Outcome_Physical", "Participant_Condition", "Intervention_Physical", "Intervention_Control", "Participant_Sample-size" ]

pain - free treadmill training, fibrinogen, claudication, plasma fibrinogen , haematocrit , lipid profile , and walking ability, Sixty - eight, peripheral obstructive arterial disease, intermittent claudication, control group, no change in physical activity, pain - free walking time ( PFWT ), maximal walking time ( MWT ), blood analyses [ for haematocrit , fibrinogen , triglycerides , and cholesterol : total , high - density lipoprotein ( HDL ) and low - density lipoprotein ( LDL ) ], Total and LDL cholesterol levels, HDL cholesterol, Haematocrit

49879_task2

Sentence: The effect of pain-free treadmill training on fibrinogen , haematocrit , and lipid profile in patients with claudication . OBJECTIVE To assess the effect of pain-free treadmill training on changes of plasma fibrinogen , haematocrit , lipid profile , and walking ability in patients with claudication . DESIGN Randomized control trial . METHODS Sixty-eight patients with peripheral obstructive arterial disease and intermittent claudication ( Fontaine stage II ) were randomly assigned into the treadmill training ( repetitive intervals to onset of claudication pain , three times a week ) or a control group ( no change in physical activity ) over 3 months . Both groups performed treadmill test to assess pain-free walking time ( PFWT ) and maximal walking time ( MWT ) and had blood analyses [ for haematocrit , fibrinogen , triglycerides , and cholesterol : total , high-density lipoprotein ( HDL ) and low-density lipoprotein ( LDL ) ] done at baseline and after 6 and 12 weeks of the study . RESULTS Total and LDL cholesterol levels in the training group decreased ( p < 0.05 ) by 14.8 % and 20,5 % , respectively . Significant ( p < 0.05 ) HDL cholesterol increased ( 14.6 % ) and triglycerides decreased ( 19 % ) in the training group but changes of all these lipids were insignificant in the control group over the 3 months . Haematocrit and fibrinogen changes were insignificant in both groups . PFWT was prolonged by 109 % and MWT increased by 54 % in the training group ( p < 0.01 ) , but not in the control group . CONCLUSION The improvement in walking time over 3 months of pain-free treadmill training parallels with progressive normalization of lipid profiles in patients with claudication . Instructions: please extract entity words from the input sentence

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The effect of pain-free treadmill training on fibrinogen , haematocrit , and lipid profile in patients with claudication . OBJECTIVE To assess the effect of pain-free treadmill training on changes of plasma fibrinogen , haematocrit , lipid profile , and walking ability in patients with claudication . DESIGN Randomized control trial . METHODS Sixty-eight patients with peripheral obstructive arterial disease and intermittent claudication ( Fontaine stage II ) were randomly assigned into the treadmill training ( repetitive intervals to onset of claudication pain , three times a week ) or a control group ( no change in physical activity ) over 3 months . Both groups performed treadmill test to assess pain-free walking time ( PFWT ) and maximal walking time ( MWT ) and had blood analyses [ for haematocrit , fibrinogen , triglycerides , and cholesterol : total , high-density lipoprotein ( HDL ) and low-density lipoprotein ( LDL ) ] done at baseline and after 6 and 12 weeks of the study . RESULTS Total and LDL cholesterol levels in the training group decreased ( p < 0.05 ) by 14.8 % and 20,5 % , respectively . Significant ( p < 0.05 ) HDL cholesterol increased ( 14.6 % ) and triglycerides decreased ( 19 % ) in the training group but changes of all these lipids were insignificant in the control group over the 3 months . Haematocrit and fibrinogen changes were insignificant in both groups . PFWT was prolonged by 109 % and MWT increased by 54 % in the training group ( p < 0.01 ) , but not in the control group . CONCLUSION The improvement in walking time over 3 months of pain-free treadmill training parallels with progressive normalization of lipid profiles in patients with claudication .

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[ "Outcome_Physical", "Participant_Condition", "Intervention_Physical", "Intervention_Control", "Participant_Sample-size" ]

Opioide is an umlsterm, Patienten is an umlsterm, Aorta abdominalis is an umlsterm, Praemedikation is an umlsterm, Diazepam is an umlsterm, Patienten is an umlsterm, Patient is an umlsterm, Buprenorphin is an umlsterm, Fentanyl is an umlsterm, Morphin is an umlsterm, Nalbuphin is an umlsterm, Pentazocin is an umlsterm, Pethidin is an umlsterm, Tramadol is an umlsterm, Alfentanil is an umlsterm, Blutgasstatus is an umlsterm, Varianzanalyse is an umlsterm, Zeiteffekte is an umlsterm, Zeiteffekte is an umlsterm, Morphin is an umlsterm, Fentanyl is an umlsterm, Alfentanil is an umlsterm, Tramadol is an umlsterm, Nalbuphin is an umlsterm, Buprenorphin is an umlsterm, Atemdepression is an umlsterm, Gefaesswiderstands is an umlsterm, Pentazocin is an umlsterm, Pethidin is an umlsterm, Pethidin is an umlsterm, Atemdepression is an umlsterm, Katecholamine is an umlsterm, Histaminausschuettung is an umlsterm, Vasokonstriktion is an umlsterm

DerAnaesthesist.40430743.ger.abstr_task0

Sentence: Ziel der vorliegenden Untersuchung war die Erfassung haemodynamischer und respiratorischer Nebenwirkungen durch 8 verschiedene Opioide bei typischen kardiovaskulaeren Risikopatienten . Nach Aufklaerung und schriftlichem Einverstaendnis wurden 57 Patienten der Risikogruppen ASA III und IV , die sich einem Eingriff an der Aorta abdominalis unterziehen sollten , in randomisierter Form 8 Gruppen zugeteilt . Die Praemedikation mit 10 mg Diazepam i.m. erfolgte 60 min vor Eintreffen des Patienten im OP . Das gesamte invasive haemodynamische Monitoring ( art . RR HZV-PA-Katheter ) , wurde in Lokalanaesthesie angelegt . Danach erhielt jeder Patient der 8 Gruppen ein Opioid in einer aequipotenten , klinischen Dosierung ( Buprenorphin , Fentanyl , Morphin , Nalbuphin , Pentazocin , Pethidin , Tramadol , Alfentanil ) . 10 und 5 min vor sowie 5 , 10 , 15 und 20 min nach i.v. -Applikation des Opioids wurde ein kompletter haemodynamischer Status und Blutgasstatus erhoben . Die statistische Auswertung erfolgte mit der 1- bzw. 2faktoriellen Varianzanalyse ( p 0,05 ) . Signifikante Zeiteffekte , d . h . Abweichungen vom Ausgangswert zu den verschiedenen Messzeitpunkten , wurden fuer die Parameter HR und TPR , signifikante Gruppen- ( d . h . unterschiedliche Kurvenverlaeufe zwischen den verschiedenen Gruppen ) und Zeiteffekte fuer MPAP , PCWP , SVI , PaCO2 und PaO2 beobachtet . Keine wesentlichen Veraenderungen wurden nach Morphin , Fentanyl , Alfentanil , Tramadol und Nalbuphin festgestellt . Buprenorphin verursachte eine deutliche Atemdepression mit Anstieg des pulmonalen Gefaesswiderstands . Die Gabe von Pentazocin und Pethidin war von einem signifikanten Anstieg des MPAP und PVR begleitet . Pethidin erwies sich als am staerksten atemdepressiv . Als Ursachen fuer die beobachteten Nebenwirkungen muessen neben einer Atemdepression Faktoren wie eine Freisetzung endogener Katecholamine , eine Histaminausschuettung sowie eine hypoxisch bedingte pulmonale Vasokonstriktion diskutiert werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Ziel der vorliegenden Untersuchung war die Erfassung haemodynamischer und respiratorischer Nebenwirkungen durch 8 verschiedene Opioide bei typischen kardiovaskulaeren Risikopatienten . Nach Aufklaerung und schriftlichem Einverstaendnis wurden 57 Patienten der Risikogruppen ASA III und IV , die sich einem Eingriff an der Aorta abdominalis unterziehen sollten , in randomisierter Form 8 Gruppen zugeteilt . Die Praemedikation mit 10 mg Diazepam i.m. erfolgte 60 min vor Eintreffen des Patienten im OP . Das gesamte invasive haemodynamische Monitoring ( art . RR HZV-PA-Katheter ) , wurde in Lokalanaesthesie angelegt . Danach erhielt jeder Patient der 8 Gruppen ein Opioid in einer aequipotenten , klinischen Dosierung ( Buprenorphin , Fentanyl , Morphin , Nalbuphin , Pentazocin , Pethidin , Tramadol , Alfentanil ) . 10 und 5 min vor sowie 5 , 10 , 15 und 20 min nach i.v. -Applikation des Opioids wurde ein kompletter haemodynamischer Status und Blutgasstatus erhoben . Die statistische Auswertung erfolgte mit der 1- bzw. 2faktoriellen Varianzanalyse ( p 0,05 ) . Signifikante Zeiteffekte , d . h . Abweichungen vom Ausgangswert zu den verschiedenen Messzeitpunkten , wurden fuer die Parameter HR und TPR , signifikante Gruppen- ( d . h . unterschiedliche Kurvenverlaeufe zwischen den verschiedenen Gruppen ) und Zeiteffekte fuer MPAP , PCWP , SVI , PaCO2 und PaO2 beobachtet . Keine wesentlichen Veraenderungen wurden nach Morphin , Fentanyl , Alfentanil , Tramadol und Nalbuphin festgestellt . Buprenorphin verursachte eine deutliche Atemdepression mit Anstieg des pulmonalen Gefaesswiderstands . Die Gabe von Pentazocin und Pethidin war von einem signifikanten Anstieg des MPAP und PVR begleitet . Pethidin erwies sich als am staerksten atemdepressiv . Als Ursachen fuer die beobachteten Nebenwirkungen muessen neben einer Atemdepression Faktoren wie eine Freisetzung endogener Katecholamine , eine Histaminausschuettung sowie eine hypoxisch bedingte pulmonale Vasokonstriktion diskutiert werden .

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[ "umlsterm" ]

Opioide is an umlsterm, Patienten is an umlsterm, Aorta abdominalis is an umlsterm, Praemedikation is an umlsterm, Diazepam is an umlsterm, Patienten is an umlsterm, Patient is an umlsterm, Buprenorphin is an umlsterm, Fentanyl is an umlsterm, Morphin is an umlsterm, Nalbuphin is an umlsterm, Pentazocin is an umlsterm, Pethidin is an umlsterm, Tramadol is an umlsterm, Alfentanil is an umlsterm, Blutgasstatus is an umlsterm, Varianzanalyse is an umlsterm, Zeiteffekte is an umlsterm, Zeiteffekte is an umlsterm, Morphin is an umlsterm, Fentanyl is an umlsterm, Alfentanil is an umlsterm, Tramadol is an umlsterm, Nalbuphin is an umlsterm, Buprenorphin is an umlsterm, Atemdepression is an umlsterm, Gefaesswiderstands is an umlsterm, Pentazocin is an umlsterm, Pethidin is an umlsterm, Pethidin is an umlsterm, Atemdepression is an umlsterm, Katecholamine is an umlsterm, Histaminausschuettung is an umlsterm, Vasokonstriktion is an umlsterm

DerAnaesthesist.40430743.ger.abstr_task1

Sentence: Ziel der vorliegenden Untersuchung war die Erfassung haemodynamischer und respiratorischer Nebenwirkungen durch 8 verschiedene Opioide bei typischen kardiovaskulaeren Risikopatienten . Nach Aufklaerung und schriftlichem Einverstaendnis wurden 57 Patienten der Risikogruppen ASA III und IV , die sich einem Eingriff an der Aorta abdominalis unterziehen sollten , in randomisierter Form 8 Gruppen zugeteilt . Die Praemedikation mit 10 mg Diazepam i.m. erfolgte 60 min vor Eintreffen des Patienten im OP . Das gesamte invasive haemodynamische Monitoring ( art . RR HZV-PA-Katheter ) , wurde in Lokalanaesthesie angelegt . Danach erhielt jeder Patient der 8 Gruppen ein Opioid in einer aequipotenten , klinischen Dosierung ( Buprenorphin , Fentanyl , Morphin , Nalbuphin , Pentazocin , Pethidin , Tramadol , Alfentanil ) . 10 und 5 min vor sowie 5 , 10 , 15 und 20 min nach i.v. -Applikation des Opioids wurde ein kompletter haemodynamischer Status und Blutgasstatus erhoben . Die statistische Auswertung erfolgte mit der 1- bzw. 2faktoriellen Varianzanalyse ( p 0,05 ) . Signifikante Zeiteffekte , d . h . Abweichungen vom Ausgangswert zu den verschiedenen Messzeitpunkten , wurden fuer die Parameter HR und TPR , signifikante Gruppen- ( d . h . unterschiedliche Kurvenverlaeufe zwischen den verschiedenen Gruppen ) und Zeiteffekte fuer MPAP , PCWP , SVI , PaCO2 und PaO2 beobachtet . Keine wesentlichen Veraenderungen wurden nach Morphin , Fentanyl , Alfentanil , Tramadol und Nalbuphin festgestellt . Buprenorphin verursachte eine deutliche Atemdepression mit Anstieg des pulmonalen Gefaesswiderstands . Die Gabe von Pentazocin und Pethidin war von einem signifikanten Anstieg des MPAP und PVR begleitet . Pethidin erwies sich als am staerksten atemdepressiv . Als Ursachen fuer die beobachteten Nebenwirkungen muessen neben einer Atemdepression Faktoren wie eine Freisetzung endogener Katecholamine , eine Histaminausschuettung sowie eine hypoxisch bedingte pulmonale Vasokonstriktion diskutiert werden . Instructions: please typing these entity words according to sentence: Opioide, Patienten, Aorta abdominalis, Praemedikation, Diazepam, Patienten, Patient, Buprenorphin, Fentanyl, Morphin, Nalbuphin, Pentazocin, Pethidin, Tramadol, Alfentanil, Blutgasstatus, Varianzanalyse, Zeiteffekte, Zeiteffekte, Morphin, Fentanyl, Alfentanil, Tramadol, Nalbuphin, Buprenorphin, Atemdepression, Gefaesswiderstands, Pentazocin, Pethidin, Pethidin, Atemdepression, Katecholamine, Histaminausschuettung, Vasokonstriktion Options: umlsterm

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Ziel der vorliegenden Untersuchung war die Erfassung haemodynamischer und respiratorischer Nebenwirkungen durch 8 verschiedene Opioide bei typischen kardiovaskulaeren Risikopatienten . Nach Aufklaerung und schriftlichem Einverstaendnis wurden 57 Patienten der Risikogruppen ASA III und IV , die sich einem Eingriff an der Aorta abdominalis unterziehen sollten , in randomisierter Form 8 Gruppen zugeteilt . Die Praemedikation mit 10 mg Diazepam i.m. erfolgte 60 min vor Eintreffen des Patienten im OP . Das gesamte invasive haemodynamische Monitoring ( art . RR HZV-PA-Katheter ) , wurde in Lokalanaesthesie angelegt . Danach erhielt jeder Patient der 8 Gruppen ein Opioid in einer aequipotenten , klinischen Dosierung ( Buprenorphin , Fentanyl , Morphin , Nalbuphin , Pentazocin , Pethidin , Tramadol , Alfentanil ) . 10 und 5 min vor sowie 5 , 10 , 15 und 20 min nach i.v. -Applikation des Opioids wurde ein kompletter haemodynamischer Status und Blutgasstatus erhoben . Die statistische Auswertung erfolgte mit der 1- bzw. 2faktoriellen Varianzanalyse ( p 0,05 ) . Signifikante Zeiteffekte , d . h . Abweichungen vom Ausgangswert zu den verschiedenen Messzeitpunkten , wurden fuer die Parameter HR und TPR , signifikante Gruppen- ( d . h . unterschiedliche Kurvenverlaeufe zwischen den verschiedenen Gruppen ) und Zeiteffekte fuer MPAP , PCWP , SVI , PaCO2 und PaO2 beobachtet . Keine wesentlichen Veraenderungen wurden nach Morphin , Fentanyl , Alfentanil , Tramadol und Nalbuphin festgestellt . Buprenorphin verursachte eine deutliche Atemdepression mit Anstieg des pulmonalen Gefaesswiderstands . Die Gabe von Pentazocin und Pethidin war von einem signifikanten Anstieg des MPAP und PVR begleitet . Pethidin erwies sich als am staerksten atemdepressiv . Als Ursachen fuer die beobachteten Nebenwirkungen muessen neben einer Atemdepression Faktoren wie eine Freisetzung endogener Katecholamine , eine Histaminausschuettung sowie eine hypoxisch bedingte pulmonale Vasokonstriktion diskutiert werden .

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[ "umlsterm" ]

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DerAnaesthesist.40430743.ger.abstr_task2

Sentence: Ziel der vorliegenden Untersuchung war die Erfassung haemodynamischer und respiratorischer Nebenwirkungen durch 8 verschiedene Opioide bei typischen kardiovaskulaeren Risikopatienten . Nach Aufklaerung und schriftlichem Einverstaendnis wurden 57 Patienten der Risikogruppen ASA III und IV , die sich einem Eingriff an der Aorta abdominalis unterziehen sollten , in randomisierter Form 8 Gruppen zugeteilt . Die Praemedikation mit 10 mg Diazepam i.m. erfolgte 60 min vor Eintreffen des Patienten im OP . Das gesamte invasive haemodynamische Monitoring ( art . RR HZV-PA-Katheter ) , wurde in Lokalanaesthesie angelegt . Danach erhielt jeder Patient der 8 Gruppen ein Opioid in einer aequipotenten , klinischen Dosierung ( Buprenorphin , Fentanyl , Morphin , Nalbuphin , Pentazocin , Pethidin , Tramadol , Alfentanil ) . 10 und 5 min vor sowie 5 , 10 , 15 und 20 min nach i.v. -Applikation des Opioids wurde ein kompletter haemodynamischer Status und Blutgasstatus erhoben . Die statistische Auswertung erfolgte mit der 1- bzw. 2faktoriellen Varianzanalyse ( p 0,05 ) . Signifikante Zeiteffekte , d . h . Abweichungen vom Ausgangswert zu den verschiedenen Messzeitpunkten , wurden fuer die Parameter HR und TPR , signifikante Gruppen- ( d . h . unterschiedliche Kurvenverlaeufe zwischen den verschiedenen Gruppen ) und Zeiteffekte fuer MPAP , PCWP , SVI , PaCO2 und PaO2 beobachtet . Keine wesentlichen Veraenderungen wurden nach Morphin , Fentanyl , Alfentanil , Tramadol und Nalbuphin festgestellt . Buprenorphin verursachte eine deutliche Atemdepression mit Anstieg des pulmonalen Gefaesswiderstands . Die Gabe von Pentazocin und Pethidin war von einem signifikanten Anstieg des MPAP und PVR begleitet . Pethidin erwies sich als am staerksten atemdepressiv . Als Ursachen fuer die beobachteten Nebenwirkungen muessen neben einer Atemdepression Faktoren wie eine Freisetzung endogener Katecholamine , eine Histaminausschuettung sowie eine hypoxisch bedingte pulmonale Vasokonstriktion diskutiert werden . Instructions: please extract entity words from the input sentence

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Ziel der vorliegenden Untersuchung war die Erfassung haemodynamischer und respiratorischer Nebenwirkungen durch 8 verschiedene Opioide bei typischen kardiovaskulaeren Risikopatienten . Nach Aufklaerung und schriftlichem Einverstaendnis wurden 57 Patienten der Risikogruppen ASA III und IV , die sich einem Eingriff an der Aorta abdominalis unterziehen sollten , in randomisierter Form 8 Gruppen zugeteilt . Die Praemedikation mit 10 mg Diazepam i.m. erfolgte 60 min vor Eintreffen des Patienten im OP . Das gesamte invasive haemodynamische Monitoring ( art . RR HZV-PA-Katheter ) , wurde in Lokalanaesthesie angelegt . Danach erhielt jeder Patient der 8 Gruppen ein Opioid in einer aequipotenten , klinischen Dosierung ( Buprenorphin , Fentanyl , Morphin , Nalbuphin , Pentazocin , Pethidin , Tramadol , Alfentanil ) . 10 und 5 min vor sowie 5 , 10 , 15 und 20 min nach i.v. -Applikation des Opioids wurde ein kompletter haemodynamischer Status und Blutgasstatus erhoben . Die statistische Auswertung erfolgte mit der 1- bzw. 2faktoriellen Varianzanalyse ( p 0,05 ) . Signifikante Zeiteffekte , d . h . Abweichungen vom Ausgangswert zu den verschiedenen Messzeitpunkten , wurden fuer die Parameter HR und TPR , signifikante Gruppen- ( d . h . unterschiedliche Kurvenverlaeufe zwischen den verschiedenen Gruppen ) und Zeiteffekte fuer MPAP , PCWP , SVI , PaCO2 und PaO2 beobachtet . Keine wesentlichen Veraenderungen wurden nach Morphin , Fentanyl , Alfentanil , Tramadol und Nalbuphin festgestellt . Buprenorphin verursachte eine deutliche Atemdepression mit Anstieg des pulmonalen Gefaesswiderstands . Die Gabe von Pentazocin und Pethidin war von einem signifikanten Anstieg des MPAP und PVR begleitet . Pethidin erwies sich als am staerksten atemdepressiv . Als Ursachen fuer die beobachteten Nebenwirkungen muessen neben einer Atemdepression Faktoren wie eine Freisetzung endogener Katecholamine , eine Histaminausschuettung sowie eine hypoxisch bedingte pulmonale Vasokonstriktion diskutiert werden .

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[ "umlsterm" ]

Antipsychotika is an umlsterm, Lebensqualitaet is an umlsterm, Patienten is an umlsterm, Stigmatisierung is an umlsterm

DerNervenarzt.00710919.ger.abstr_task0

Sentence: Mit der Einfuehrung der sog . atypischen Antipsychotika verbesserte sich die Lebensqualitaet von Patienten mit einer schizophrenen Spektrumserkrankung erheblich . Die positiven Effekte zeigen sich sowohl in einer Reduzierung extrapyramidalmotorischer Nebenwirkungen und damit geringerer Stigmatisierung als auch in verbesserter kognitiver Leistungsfaehigkeit , erleichterter sozialer Integration , verkuerzter stationaerer Aufenthaltsdauer und geringeren Wiederaufnahmeraten . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Mit der Einfuehrung der sog . atypischen Antipsychotika verbesserte sich die Lebensqualitaet von Patienten mit einer schizophrenen Spektrumserkrankung erheblich . Die positiven Effekte zeigen sich sowohl in einer Reduzierung extrapyramidalmotorischer Nebenwirkungen und damit geringerer Stigmatisierung als auch in verbesserter kognitiver Leistungsfaehigkeit , erleichterter sozialer Integration , verkuerzter stationaerer Aufenthaltsdauer und geringeren Wiederaufnahmeraten .

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[ "umlsterm" ]

Antipsychotika is an umlsterm, Lebensqualitaet is an umlsterm, Patienten is an umlsterm, Stigmatisierung is an umlsterm

DerNervenarzt.00710919.ger.abstr_task1

Sentence: Mit der Einfuehrung der sog . atypischen Antipsychotika verbesserte sich die Lebensqualitaet von Patienten mit einer schizophrenen Spektrumserkrankung erheblich . Die positiven Effekte zeigen sich sowohl in einer Reduzierung extrapyramidalmotorischer Nebenwirkungen und damit geringerer Stigmatisierung als auch in verbesserter kognitiver Leistungsfaehigkeit , erleichterter sozialer Integration , verkuerzter stationaerer Aufenthaltsdauer und geringeren Wiederaufnahmeraten . Instructions: please typing these entity words according to sentence: Antipsychotika, Lebensqualitaet, Patienten, Stigmatisierung Options: umlsterm

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Mit der Einfuehrung der sog . atypischen Antipsychotika verbesserte sich die Lebensqualitaet von Patienten mit einer schizophrenen Spektrumserkrankung erheblich . Die positiven Effekte zeigen sich sowohl in einer Reduzierung extrapyramidalmotorischer Nebenwirkungen und damit geringerer Stigmatisierung als auch in verbesserter kognitiver Leistungsfaehigkeit , erleichterter sozialer Integration , verkuerzter stationaerer Aufenthaltsdauer und geringeren Wiederaufnahmeraten .

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[ "umlsterm" ]

Antipsychotika, Lebensqualitaet, Patienten, Stigmatisierung

DerNervenarzt.00710919.ger.abstr_task2

Sentence: Mit der Einfuehrung der sog . atypischen Antipsychotika verbesserte sich die Lebensqualitaet von Patienten mit einer schizophrenen Spektrumserkrankung erheblich . Die positiven Effekte zeigen sich sowohl in einer Reduzierung extrapyramidalmotorischer Nebenwirkungen und damit geringerer Stigmatisierung als auch in verbesserter kognitiver Leistungsfaehigkeit , erleichterter sozialer Integration , verkuerzter stationaerer Aufenthaltsdauer und geringeren Wiederaufnahmeraten . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Mit der Einfuehrung der sog . atypischen Antipsychotika verbesserte sich die Lebensqualitaet von Patienten mit einer schizophrenen Spektrumserkrankung erheblich . Die positiven Effekte zeigen sich sowohl in einer Reduzierung extrapyramidalmotorischer Nebenwirkungen und damit geringerer Stigmatisierung als auch in verbesserter kognitiver Leistungsfaehigkeit , erleichterter sozialer Integration , verkuerzter stationaerer Aufenthaltsdauer und geringeren Wiederaufnahmeraten .

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[ "umlsterm" ]

surgeries is an umlsterm, tissues is an umlsterm, forceps is an umlsterm, procedure is an umlsterm, forceps is an umlsterm, hemostasis is an umlsterm, method is an umlsterm, irrigation is an umlsterm, forceps is an umlsterm, sodium chloride solution is an umlsterm, coagulation is an umlsterm, irrigation is an umlsterm, forceps is an umlsterm, surgery is an umlsterm, irrigation is an umlsterm, sodium chloride solution is an umlsterm, imaging is an umlsterm, coagulation is an umlsterm, tissue is an umlsterm, faster is an umlsterm, coagulation is an umlsterm, tip is an umlsterm, forceps is an umlsterm, coagulation is an umlsterm, experimental - surgical is an umlsterm, tests is an umlsterm, forceps is an umlsterm, methods is an umlsterm, tissue is an umlsterm, coagulation is an umlsterm, irrigation is an umlsterm, electrode is an umlsterm, development is an umlsterm, time is an umlsterm, risk of is an umlsterm, complications is an umlsterm

MundKieferGesichtschirurgie.00040324.eng.abstr_task0

Sentence: Problem : During most surgeries , tissues are coagulated by a high-frequency current in order to stop the bleeding . Usually , bipolar forceps are used for this procedure . Until now it could not be avoided , however , that the biotissue would adhere to the forceps ends making hemostasis more difficult to achieve . Can this negative effect possibly be avoided ? Material and method : A newly developed bipolar irrigation forceps spilling out a 0.9% sodium chloride solution during the coagulation process has been designed to avoid this disadvantage . The irrigation forceps has been tested and evaluated experimentally in surgery as well as clinically . Results : The irrigation liquid selected is a 0.9% sodium chloride solution . Thermal imaging during biotissue coagulation has shown that the tissue heats up more and faster with flushed coagulation , and that the tip of the forceps heats up less than with unirrigated coagulation . In both experimental-surgical as well as in clinical tests it was possible to stop the biotissue sticking to the ends of the forceps . This effect was also confirmed histologically . Conclusion : Since other methods of avoiding the sticking effect during tissue coagulation by a high-frequency current have not been successful until now , the bipolar irrigation electrode is a promising new development . It helps the surgeon to work more efficiently and safely without having to adapt to big changes , and , at the same time , it reduces the risk of complications . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Problem : During most surgeries , tissues are coagulated by a high-frequency current in order to stop the bleeding . Usually , bipolar forceps are used for this procedure . Until now it could not be avoided , however , that the biotissue would adhere to the forceps ends making hemostasis more difficult to achieve . Can this negative effect possibly be avoided ? Material and method : A newly developed bipolar irrigation forceps spilling out a 0.9% sodium chloride solution during the coagulation process has been designed to avoid this disadvantage . The irrigation forceps has been tested and evaluated experimentally in surgery as well as clinically . Results : The irrigation liquid selected is a 0.9% sodium chloride solution . Thermal imaging during biotissue coagulation has shown that the tissue heats up more and faster with flushed coagulation , and that the tip of the forceps heats up less than with unirrigated coagulation . In both experimental-surgical as well as in clinical tests it was possible to stop the biotissue sticking to the ends of the forceps . This effect was also confirmed histologically . Conclusion : Since other methods of avoiding the sticking effect during tissue coagulation by a high-frequency current have not been successful until now , the bipolar irrigation electrode is a promising new development . It helps the surgeon to work more efficiently and safely without having to adapt to big changes , and , at the same time , it reduces the risk of complications .

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[ "umlsterm" ]

surgeries is an umlsterm, tissues is an umlsterm, forceps is an umlsterm, procedure is an umlsterm, forceps is an umlsterm, hemostasis is an umlsterm, method is an umlsterm, irrigation is an umlsterm, forceps is an umlsterm, sodium chloride solution is an umlsterm, coagulation is an umlsterm, irrigation is an umlsterm, forceps is an umlsterm, surgery is an umlsterm, irrigation is an umlsterm, sodium chloride solution is an umlsterm, imaging is an umlsterm, coagulation is an umlsterm, tissue is an umlsterm, faster is an umlsterm, coagulation is an umlsterm, tip is an umlsterm, forceps is an umlsterm, coagulation is an umlsterm, experimental - surgical is an umlsterm, tests is an umlsterm, forceps is an umlsterm, methods is an umlsterm, tissue is an umlsterm, coagulation is an umlsterm, irrigation is an umlsterm, electrode is an umlsterm, development is an umlsterm, time is an umlsterm, risk of is an umlsterm, complications is an umlsterm

MundKieferGesichtschirurgie.00040324.eng.abstr_task1

Sentence: Problem : During most surgeries , tissues are coagulated by a high-frequency current in order to stop the bleeding . Usually , bipolar forceps are used for this procedure . Until now it could not be avoided , however , that the biotissue would adhere to the forceps ends making hemostasis more difficult to achieve . Can this negative effect possibly be avoided ? Material and method : A newly developed bipolar irrigation forceps spilling out a 0.9% sodium chloride solution during the coagulation process has been designed to avoid this disadvantage . The irrigation forceps has been tested and evaluated experimentally in surgery as well as clinically . Results : The irrigation liquid selected is a 0.9% sodium chloride solution . Thermal imaging during biotissue coagulation has shown that the tissue heats up more and faster with flushed coagulation , and that the tip of the forceps heats up less than with unirrigated coagulation . In both experimental-surgical as well as in clinical tests it was possible to stop the biotissue sticking to the ends of the forceps . This effect was also confirmed histologically . Conclusion : Since other methods of avoiding the sticking effect during tissue coagulation by a high-frequency current have not been successful until now , the bipolar irrigation electrode is a promising new development . It helps the surgeon to work more efficiently and safely without having to adapt to big changes , and , at the same time , it reduces the risk of complications . Instructions: please typing these entity words according to sentence: surgeries, tissues, forceps, procedure, forceps, hemostasis, method, irrigation, forceps, sodium chloride solution, coagulation, irrigation, forceps, surgery, irrigation, sodium chloride solution, imaging, coagulation, tissue, faster, coagulation, tip, forceps, coagulation, experimental - surgical, tests, forceps, methods, tissue, coagulation, irrigation, electrode, development, time, risk of, complications Options: umlsterm

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Problem : During most surgeries , tissues are coagulated by a high-frequency current in order to stop the bleeding . Usually , bipolar forceps are used for this procedure . Until now it could not be avoided , however , that the biotissue would adhere to the forceps ends making hemostasis more difficult to achieve . Can this negative effect possibly be avoided ? Material and method : A newly developed bipolar irrigation forceps spilling out a 0.9% sodium chloride solution during the coagulation process has been designed to avoid this disadvantage . The irrigation forceps has been tested and evaluated experimentally in surgery as well as clinically . Results : The irrigation liquid selected is a 0.9% sodium chloride solution . Thermal imaging during biotissue coagulation has shown that the tissue heats up more and faster with flushed coagulation , and that the tip of the forceps heats up less than with unirrigated coagulation . In both experimental-surgical as well as in clinical tests it was possible to stop the biotissue sticking to the ends of the forceps . This effect was also confirmed histologically . Conclusion : Since other methods of avoiding the sticking effect during tissue coagulation by a high-frequency current have not been successful until now , the bipolar irrigation electrode is a promising new development . It helps the surgeon to work more efficiently and safely without having to adapt to big changes , and , at the same time , it reduces the risk of complications .

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[ "umlsterm" ]

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MundKieferGesichtschirurgie.00040324.eng.abstr_task2

Sentence: Problem : During most surgeries , tissues are coagulated by a high-frequency current in order to stop the bleeding . Usually , bipolar forceps are used for this procedure . Until now it could not be avoided , however , that the biotissue would adhere to the forceps ends making hemostasis more difficult to achieve . Can this negative effect possibly be avoided ? Material and method : A newly developed bipolar irrigation forceps spilling out a 0.9% sodium chloride solution during the coagulation process has been designed to avoid this disadvantage . The irrigation forceps has been tested and evaluated experimentally in surgery as well as clinically . Results : The irrigation liquid selected is a 0.9% sodium chloride solution . Thermal imaging during biotissue coagulation has shown that the tissue heats up more and faster with flushed coagulation , and that the tip of the forceps heats up less than with unirrigated coagulation . In both experimental-surgical as well as in clinical tests it was possible to stop the biotissue sticking to the ends of the forceps . This effect was also confirmed histologically . Conclusion : Since other methods of avoiding the sticking effect during tissue coagulation by a high-frequency current have not been successful until now , the bipolar irrigation electrode is a promising new development . It helps the surgeon to work more efficiently and safely without having to adapt to big changes , and , at the same time , it reduces the risk of complications . Instructions: please extract entity words from the input sentence

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Problem : During most surgeries , tissues are coagulated by a high-frequency current in order to stop the bleeding . Usually , bipolar forceps are used for this procedure . Until now it could not be avoided , however , that the biotissue would adhere to the forceps ends making hemostasis more difficult to achieve . Can this negative effect possibly be avoided ? Material and method : A newly developed bipolar irrigation forceps spilling out a 0.9% sodium chloride solution during the coagulation process has been designed to avoid this disadvantage . The irrigation forceps has been tested and evaluated experimentally in surgery as well as clinically . Results : The irrigation liquid selected is a 0.9% sodium chloride solution . Thermal imaging during biotissue coagulation has shown that the tissue heats up more and faster with flushed coagulation , and that the tip of the forceps heats up less than with unirrigated coagulation . In both experimental-surgical as well as in clinical tests it was possible to stop the biotissue sticking to the ends of the forceps . This effect was also confirmed histologically . Conclusion : Since other methods of avoiding the sticking effect during tissue coagulation by a high-frequency current have not been successful until now , the bipolar irrigation electrode is a promising new development . It helps the surgeon to work more efficiently and safely without having to adapt to big changes , and , at the same time , it reduces the risk of complications .

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[ "umlsterm" ]

aortic valve is an umlsterm, tumor is an umlsterm, mesothelioma is an umlsterm, autopsy is an umlsterm, tumor is an umlsterm, right is an umlsterm, myocardial infarction is an umlsterm, heart is an umlsterm, tumor is an umlsterm, atrioventricular node is an umlsterm, knowledge is an umlsterm, tumors is an umlsterm

DerPathologe.00210250.eng.abstr_task0

Sentence: We describe a rare case of a papillary fibroelastoma of the aortic valve occurring simultaneously with a cystic tumor ( a so-called mesothelioma ) of the atrioventricular nodal region . At autopsy the tumor was found to prolapse into and occlude the right coronary ostium , leading to an acute , recurring myocardial infarction . Histological examination of the grossly unremarkable conduction system of the heart revealed a cystic tumor in the region of the atrioventricular node . To our knowledge , this is the first report of coexistence of these two rare cardiac tumors . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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We describe a rare case of a papillary fibroelastoma of the aortic valve occurring simultaneously with a cystic tumor ( a so-called mesothelioma ) of the atrioventricular nodal region . At autopsy the tumor was found to prolapse into and occlude the right coronary ostium , leading to an acute , recurring myocardial infarction . Histological examination of the grossly unremarkable conduction system of the heart revealed a cystic tumor in the region of the atrioventricular node . To our knowledge , this is the first report of coexistence of these two rare cardiac tumors .

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[ "umlsterm" ]

aortic valve is an umlsterm, tumor is an umlsterm, mesothelioma is an umlsterm, autopsy is an umlsterm, tumor is an umlsterm, right is an umlsterm, myocardial infarction is an umlsterm, heart is an umlsterm, tumor is an umlsterm, atrioventricular node is an umlsterm, knowledge is an umlsterm, tumors is an umlsterm

DerPathologe.00210250.eng.abstr_task1

Sentence: We describe a rare case of a papillary fibroelastoma of the aortic valve occurring simultaneously with a cystic tumor ( a so-called mesothelioma ) of the atrioventricular nodal region . At autopsy the tumor was found to prolapse into and occlude the right coronary ostium , leading to an acute , recurring myocardial infarction . Histological examination of the grossly unremarkable conduction system of the heart revealed a cystic tumor in the region of the atrioventricular node . To our knowledge , this is the first report of coexistence of these two rare cardiac tumors . Instructions: please typing these entity words according to sentence: aortic valve, tumor, mesothelioma, autopsy, tumor, right, myocardial infarction, heart, tumor, atrioventricular node, knowledge, tumors Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

We describe a rare case of a papillary fibroelastoma of the aortic valve occurring simultaneously with a cystic tumor ( a so-called mesothelioma ) of the atrioventricular nodal region . At autopsy the tumor was found to prolapse into and occlude the right coronary ostium , leading to an acute , recurring myocardial infarction . Histological examination of the grossly unremarkable conduction system of the heart revealed a cystic tumor in the region of the atrioventricular node . To our knowledge , this is the first report of coexistence of these two rare cardiac tumors .

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[ "umlsterm" ]

aortic valve, tumor, mesothelioma, autopsy, tumor, right, myocardial infarction, heart, tumor, atrioventricular node, knowledge, tumors

DerPathologe.00210250.eng.abstr_task2

Sentence: We describe a rare case of a papillary fibroelastoma of the aortic valve occurring simultaneously with a cystic tumor ( a so-called mesothelioma ) of the atrioventricular nodal region . At autopsy the tumor was found to prolapse into and occlude the right coronary ostium , leading to an acute , recurring myocardial infarction . Histological examination of the grossly unremarkable conduction system of the heart revealed a cystic tumor in the region of the atrioventricular node . To our knowledge , this is the first report of coexistence of these two rare cardiac tumors . Instructions: please extract entity words from the input sentence

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We describe a rare case of a papillary fibroelastoma of the aortic valve occurring simultaneously with a cystic tumor ( a so-called mesothelioma ) of the atrioventricular nodal region . At autopsy the tumor was found to prolapse into and occlude the right coronary ostium , leading to an acute , recurring myocardial infarction . Histological examination of the grossly unremarkable conduction system of the heart revealed a cystic tumor in the region of the atrioventricular node . To our knowledge , this is the first report of coexistence of these two rare cardiac tumors .

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[ "umlsterm" ]

Tumoren is an umlsterm, Knochentumoren is an umlsterm, Archiv is an umlsterm, Knochentumoren is an umlsterm, Riesenzelltumoren is an umlsterm, Wissen is an umlsterm, Knochentumoren is an umlsterm, Techniken is an umlsterm, Tumoren is an umlsterm

DerRadiologe.80380467.ger.abstr_task0

Sentence: Osteosarkome Chondrosarkome und Tumoren , der Ewing-Gruppe sind die weitaus haeufigsten primaeren boesartigen Knochentumoren . In einer juengst eingerichteten Internet-Homepage des Orthopaedischen Spital Rizzoli in Bologna , die das Archiv dieser Institution seit dem Jahre 1900 wiedergibt , stellen diese Entitaeten den Grossteil von beobachteten malignen Knochentumoren dar . Seltener werden maligne fibroese Histiozytome , Fibrosarkome , Haemangioendotheliome , maligne Hemangioperizytome und Riesenzelltumoren diagnostiziert . Das Wissen ueber genetische Veraenderungen bei malignen Knochentumoren hat in den letzten Jahren durch den breiten Einsatz moderner molekularer und zytogenetischer Techniken stark zugenommen . Bisher konnte jedoch nur fuer Tumoren der Ewing-Gruppe ein konstant nachweisbares genetisches Merkmal identifiziert werden , das in einer fuer diese Erkrankung pathognomonischen chromosomalen Translokation t ( 11 ; 22 q24;q12) ) ( besteht . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Osteosarkome Chondrosarkome und Tumoren , der Ewing-Gruppe sind die weitaus haeufigsten primaeren boesartigen Knochentumoren . In einer juengst eingerichteten Internet-Homepage des Orthopaedischen Spital Rizzoli in Bologna , die das Archiv dieser Institution seit dem Jahre 1900 wiedergibt , stellen diese Entitaeten den Grossteil von beobachteten malignen Knochentumoren dar . Seltener werden maligne fibroese Histiozytome , Fibrosarkome , Haemangioendotheliome , maligne Hemangioperizytome und Riesenzelltumoren diagnostiziert . Das Wissen ueber genetische Veraenderungen bei malignen Knochentumoren hat in den letzten Jahren durch den breiten Einsatz moderner molekularer und zytogenetischer Techniken stark zugenommen . Bisher konnte jedoch nur fuer Tumoren der Ewing-Gruppe ein konstant nachweisbares genetisches Merkmal identifiziert werden , das in einer fuer diese Erkrankung pathognomonischen chromosomalen Translokation t ( 11 ; 22 q24;q12) ) ( besteht .

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[ "umlsterm" ]

Tumoren is an umlsterm, Knochentumoren is an umlsterm, Archiv is an umlsterm, Knochentumoren is an umlsterm, Riesenzelltumoren is an umlsterm, Wissen is an umlsterm, Knochentumoren is an umlsterm, Techniken is an umlsterm, Tumoren is an umlsterm

DerRadiologe.80380467.ger.abstr_task1

Sentence: Osteosarkome Chondrosarkome und Tumoren , der Ewing-Gruppe sind die weitaus haeufigsten primaeren boesartigen Knochentumoren . In einer juengst eingerichteten Internet-Homepage des Orthopaedischen Spital Rizzoli in Bologna , die das Archiv dieser Institution seit dem Jahre 1900 wiedergibt , stellen diese Entitaeten den Grossteil von beobachteten malignen Knochentumoren dar . Seltener werden maligne fibroese Histiozytome , Fibrosarkome , Haemangioendotheliome , maligne Hemangioperizytome und Riesenzelltumoren diagnostiziert . Das Wissen ueber genetische Veraenderungen bei malignen Knochentumoren hat in den letzten Jahren durch den breiten Einsatz moderner molekularer und zytogenetischer Techniken stark zugenommen . Bisher konnte jedoch nur fuer Tumoren der Ewing-Gruppe ein konstant nachweisbares genetisches Merkmal identifiziert werden , das in einer fuer diese Erkrankung pathognomonischen chromosomalen Translokation t ( 11 ; 22 q24;q12) ) ( besteht . Instructions: please typing these entity words according to sentence: Tumoren, Knochentumoren, Archiv, Knochentumoren, Riesenzelltumoren, Wissen, Knochentumoren, Techniken, Tumoren Options: umlsterm

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Osteosarkome Chondrosarkome und Tumoren , der Ewing-Gruppe sind die weitaus haeufigsten primaeren boesartigen Knochentumoren . In einer juengst eingerichteten Internet-Homepage des Orthopaedischen Spital Rizzoli in Bologna , die das Archiv dieser Institution seit dem Jahre 1900 wiedergibt , stellen diese Entitaeten den Grossteil von beobachteten malignen Knochentumoren dar . Seltener werden maligne fibroese Histiozytome , Fibrosarkome , Haemangioendotheliome , maligne Hemangioperizytome und Riesenzelltumoren diagnostiziert . Das Wissen ueber genetische Veraenderungen bei malignen Knochentumoren hat in den letzten Jahren durch den breiten Einsatz moderner molekularer und zytogenetischer Techniken stark zugenommen . Bisher konnte jedoch nur fuer Tumoren der Ewing-Gruppe ein konstant nachweisbares genetisches Merkmal identifiziert werden , das in einer fuer diese Erkrankung pathognomonischen chromosomalen Translokation t ( 11 ; 22 q24;q12) ) ( besteht .

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[ "umlsterm" ]

Tumoren, Knochentumoren, Archiv, Knochentumoren, Riesenzelltumoren, Wissen, Knochentumoren, Techniken, Tumoren

DerRadiologe.80380467.ger.abstr_task2

Sentence: Osteosarkome Chondrosarkome und Tumoren , der Ewing-Gruppe sind die weitaus haeufigsten primaeren boesartigen Knochentumoren . In einer juengst eingerichteten Internet-Homepage des Orthopaedischen Spital Rizzoli in Bologna , die das Archiv dieser Institution seit dem Jahre 1900 wiedergibt , stellen diese Entitaeten den Grossteil von beobachteten malignen Knochentumoren dar . Seltener werden maligne fibroese Histiozytome , Fibrosarkome , Haemangioendotheliome , maligne Hemangioperizytome und Riesenzelltumoren diagnostiziert . Das Wissen ueber genetische Veraenderungen bei malignen Knochentumoren hat in den letzten Jahren durch den breiten Einsatz moderner molekularer und zytogenetischer Techniken stark zugenommen . Bisher konnte jedoch nur fuer Tumoren der Ewing-Gruppe ein konstant nachweisbares genetisches Merkmal identifiziert werden , das in einer fuer diese Erkrankung pathognomonischen chromosomalen Translokation t ( 11 ; 22 q24;q12) ) ( besteht . Instructions: please extract entity words from the input sentence

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Osteosarkome Chondrosarkome und Tumoren , der Ewing-Gruppe sind die weitaus haeufigsten primaeren boesartigen Knochentumoren . In einer juengst eingerichteten Internet-Homepage des Orthopaedischen Spital Rizzoli in Bologna , die das Archiv dieser Institution seit dem Jahre 1900 wiedergibt , stellen diese Entitaeten den Grossteil von beobachteten malignen Knochentumoren dar . Seltener werden maligne fibroese Histiozytome , Fibrosarkome , Haemangioendotheliome , maligne Hemangioperizytome und Riesenzelltumoren diagnostiziert . Das Wissen ueber genetische Veraenderungen bei malignen Knochentumoren hat in den letzten Jahren durch den breiten Einsatz moderner molekularer und zytogenetischer Techniken stark zugenommen . Bisher konnte jedoch nur fuer Tumoren der Ewing-Gruppe ein konstant nachweisbares genetisches Merkmal identifiziert werden , das in einer fuer diese Erkrankung pathognomonischen chromosomalen Translokation t ( 11 ; 22 q24;q12) ) ( besteht .

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[ "umlsterm" ]

EMG is an umlsterm, Methode is an umlsterm, EMG is an umlsterm, Blasensphinkter is an umlsterm, EMG is an umlsterm

DerUrologeA.70360356.ger.abstr_task0

Sentence: Elektrophysiologische Untersuchungen liefern wichtige Befunde in der Abklaerung urogenitaler Funktionsstoerungen . Zur Feststellung einer Schaedigung der somatomotorischen Strecke wird neben der Nervreizung des Pudendus das Elektromyogramm ( EMG ) vom M. sphincter ani externus routinemaessig abgeleitet . Alternativ kann auch der M. sphincter vesicae externus elektromyographisch untersucht werden . Der zeitliche Aufwand ist etwas hoeher , eine ausreichende Erfahrung mit dieser speziellen Methode ist unabdingbar . Wir sehen eine Indikation fuer das EMG vom willkuerlichen Blasensphinkter bei urogenitalen Funktionsstoerungen , die durch das EMG vom Analsphinkter nicht suffizient differenziert werden koennen , sowie bei Funktionsstoerungen die selektiv den M. sphincter vesicae externus betreffen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Elektrophysiologische Untersuchungen liefern wichtige Befunde in der Abklaerung urogenitaler Funktionsstoerungen . Zur Feststellung einer Schaedigung der somatomotorischen Strecke wird neben der Nervreizung des Pudendus das Elektromyogramm ( EMG ) vom M. sphincter ani externus routinemaessig abgeleitet . Alternativ kann auch der M. sphincter vesicae externus elektromyographisch untersucht werden . Der zeitliche Aufwand ist etwas hoeher , eine ausreichende Erfahrung mit dieser speziellen Methode ist unabdingbar . Wir sehen eine Indikation fuer das EMG vom willkuerlichen Blasensphinkter bei urogenitalen Funktionsstoerungen , die durch das EMG vom Analsphinkter nicht suffizient differenziert werden koennen , sowie bei Funktionsstoerungen die selektiv den M. sphincter vesicae externus betreffen .

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[ "umlsterm" ]

EMG is an umlsterm, Methode is an umlsterm, EMG is an umlsterm, Blasensphinkter is an umlsterm, EMG is an umlsterm

DerUrologeA.70360356.ger.abstr_task1

Sentence: Elektrophysiologische Untersuchungen liefern wichtige Befunde in der Abklaerung urogenitaler Funktionsstoerungen . Zur Feststellung einer Schaedigung der somatomotorischen Strecke wird neben der Nervreizung des Pudendus das Elektromyogramm ( EMG ) vom M. sphincter ani externus routinemaessig abgeleitet . Alternativ kann auch der M. sphincter vesicae externus elektromyographisch untersucht werden . Der zeitliche Aufwand ist etwas hoeher , eine ausreichende Erfahrung mit dieser speziellen Methode ist unabdingbar . Wir sehen eine Indikation fuer das EMG vom willkuerlichen Blasensphinkter bei urogenitalen Funktionsstoerungen , die durch das EMG vom Analsphinkter nicht suffizient differenziert werden koennen , sowie bei Funktionsstoerungen die selektiv den M. sphincter vesicae externus betreffen . Instructions: please typing these entity words according to sentence: EMG, Methode, EMG, Blasensphinkter, EMG Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Elektrophysiologische Untersuchungen liefern wichtige Befunde in der Abklaerung urogenitaler Funktionsstoerungen . Zur Feststellung einer Schaedigung der somatomotorischen Strecke wird neben der Nervreizung des Pudendus das Elektromyogramm ( EMG ) vom M. sphincter ani externus routinemaessig abgeleitet . Alternativ kann auch der M. sphincter vesicae externus elektromyographisch untersucht werden . Der zeitliche Aufwand ist etwas hoeher , eine ausreichende Erfahrung mit dieser speziellen Methode ist unabdingbar . Wir sehen eine Indikation fuer das EMG vom willkuerlichen Blasensphinkter bei urogenitalen Funktionsstoerungen , die durch das EMG vom Analsphinkter nicht suffizient differenziert werden koennen , sowie bei Funktionsstoerungen die selektiv den M. sphincter vesicae externus betreffen .

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[ "umlsterm" ]

EMG, Methode, EMG, Blasensphinkter, EMG

DerUrologeA.70360356.ger.abstr_task2

Sentence: Elektrophysiologische Untersuchungen liefern wichtige Befunde in der Abklaerung urogenitaler Funktionsstoerungen . Zur Feststellung einer Schaedigung der somatomotorischen Strecke wird neben der Nervreizung des Pudendus das Elektromyogramm ( EMG ) vom M. sphincter ani externus routinemaessig abgeleitet . Alternativ kann auch der M. sphincter vesicae externus elektromyographisch untersucht werden . Der zeitliche Aufwand ist etwas hoeher , eine ausreichende Erfahrung mit dieser speziellen Methode ist unabdingbar . Wir sehen eine Indikation fuer das EMG vom willkuerlichen Blasensphinkter bei urogenitalen Funktionsstoerungen , die durch das EMG vom Analsphinkter nicht suffizient differenziert werden koennen , sowie bei Funktionsstoerungen die selektiv den M. sphincter vesicae externus betreffen . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Elektrophysiologische Untersuchungen liefern wichtige Befunde in der Abklaerung urogenitaler Funktionsstoerungen . Zur Feststellung einer Schaedigung der somatomotorischen Strecke wird neben der Nervreizung des Pudendus das Elektromyogramm ( EMG ) vom M. sphincter ani externus routinemaessig abgeleitet . Alternativ kann auch der M. sphincter vesicae externus elektromyographisch untersucht werden . Der zeitliche Aufwand ist etwas hoeher , eine ausreichende Erfahrung mit dieser speziellen Methode ist unabdingbar . Wir sehen eine Indikation fuer das EMG vom willkuerlichen Blasensphinkter bei urogenitalen Funktionsstoerungen , die durch das EMG vom Analsphinkter nicht suffizient differenziert werden koennen , sowie bei Funktionsstoerungen die selektiv den M. sphincter vesicae externus betreffen .

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[ "umlsterm" ]

Caffeine is a CHEMICAL, kinase is a GENE-N, ATM is a GENE-Y

10531013_task0

Sentence: Caffeine inhibits the checkpoint kinase ATM. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, GENE-N, CHEMICAL

[ "B-CHEMICAL", "O", "O", "O", "B-GENE-N", "B-GENE-Y", "O" ]

Caffeine inhibits the checkpoint kinase ATM.

[ "Caffeine", "inhibits", "the", "checkpoint", "kinase", "ATM", "." ]

[ "CHEMICAL", "GENE-N", "GENE-Y" ]

Caffeine is a CHEMICAL, kinase is a GENE-N, ATM is a GENE-Y

10531013_task1

Sentence: Caffeine inhibits the checkpoint kinase ATM. Instructions: please typing these entity words according to sentence: Caffeine, kinase, ATM Options: GENE-Y, GENE-N, CHEMICAL

[ "B-CHEMICAL", "O", "O", "O", "B-GENE-N", "B-GENE-Y", "O" ]

Caffeine inhibits the checkpoint kinase ATM.

[ "Caffeine", "inhibits", "the", "checkpoint", "kinase", "ATM", "." ]

[ "CHEMICAL", "GENE-N", "GENE-Y" ]

Caffeine, kinase, ATM

10531013_task2

Sentence: Caffeine inhibits the checkpoint kinase ATM. Instructions: please extract entity words from the input sentence

[ "B-CHEMICAL", "O", "O", "O", "B-GENE-N", "B-GENE-Y", "O" ]

Caffeine inhibits the checkpoint kinase ATM.

[ "Caffeine", "inhibits", "the", "checkpoint", "kinase", "ATM", "." ]

[ "CHEMICAL", "GENE-N", "GENE-Y" ]

Tetracycline is a DRUG, bacteriostatic antibiotic is a GROUP, penicillin is a DRUG

Nafcillin_ddi_task0

Sentence: Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin and concurrent use of these drugs should be avoided. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GROUP, DRUG

[ "B-DRUG", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin and concurrent use of these drugs should be avoided.

[ "Tetracycline", ",", "a", "bacteriostatic", "antibiotic", ",", "may", "antagonize", "the", "bactericidal", "effect", "of", "penicillin", "and", "concurrent", "use", "of", "these", "drugs", "should", "be", "avoided", "." ]

[ "GROUP", "DRUG" ]

Tetracycline is a DRUG, bacteriostatic antibiotic is a GROUP, penicillin is a DRUG

Nafcillin_ddi_task1

Sentence: Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin and concurrent use of these drugs should be avoided. Instructions: please typing these entity words according to sentence: Tetracycline, bacteriostatic antibiotic, penicillin Options: GROUP, DRUG

[ "B-DRUG", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin and concurrent use of these drugs should be avoided.

[ "Tetracycline", ",", "a", "bacteriostatic", "antibiotic", ",", "may", "antagonize", "the", "bactericidal", "effect", "of", "penicillin", "and", "concurrent", "use", "of", "these", "drugs", "should", "be", "avoided", "." ]

[ "GROUP", "DRUG" ]

Tetracycline, bacteriostatic antibiotic, penicillin

Nafcillin_ddi_task2

Sentence: Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin and concurrent use of these drugs should be avoided. Instructions: please extract entity words from the input sentence

[ "B-DRUG", "O", "O", "B-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin and concurrent use of these drugs should be avoided.

[ "Tetracycline", ",", "a", "bacteriostatic", "antibiotic", ",", "may", "antagonize", "the", "bactericidal", "effect", "of", "penicillin", "and", "concurrent", "use", "of", "these", "drugs", "should", "be", "avoided", "." ]

[ "GROUP", "DRUG" ]

Neugeborenes is an umlsterm, Geburtsgewicht is an umlsterm, Therapie is an umlsterm, Digitalis is an umlsterm, Diuretika is an umlsterm, Behandlung is an umlsterm, Lebenstag is an umlsterm, Therapie is an umlsterm, Tumorgefaesse is an umlsterm, Patienten is an umlsterm, Tumors is an umlsterm

ZfuerKardiologie.80870832.ger.abstr_task0

Sentence: Wir berichten ueber ein Neugeborenes ( Geburtsgewicht 3660 g ) , welches postpartal wegen eines hepatischen Haemangioendothelioms und dem damit verbundenen arteriovenoesen Shuntvolumen kardiorespiratorisch dekompensierte . Eine Therapie der Herzinsuffizienz mit Digitalis und Diuretika sowie eine Behandlung mit Kortikosteroiden wurde am 1. Lebenstag begonnen , konnte die Symptomatik jedoch nicht verbessern . Aus diesem Grund wurde eine interventionelle Therapie des Haemangioendothelioms mittels Coil-Okklusion der arteriellen Tumorgefaesse durchgefuehrt . Die Symptomatik des Patienten besserte sich daraufhin rasch , er konnte 4 Tage nach der Embolisation extubiert werden . Die sonographische Kontrolle nach 4 Monaten zeigte eine deutliche Regression des Tumors . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

Wir berichten ueber ein Neugeborenes ( Geburtsgewicht 3660 g ) , welches postpartal wegen eines hepatischen Haemangioendothelioms und dem damit verbundenen arteriovenoesen Shuntvolumen kardiorespiratorisch dekompensierte . Eine Therapie der Herzinsuffizienz mit Digitalis und Diuretika sowie eine Behandlung mit Kortikosteroiden wurde am 1. Lebenstag begonnen , konnte die Symptomatik jedoch nicht verbessern . Aus diesem Grund wurde eine interventionelle Therapie des Haemangioendothelioms mittels Coil-Okklusion der arteriellen Tumorgefaesse durchgefuehrt . Die Symptomatik des Patienten besserte sich daraufhin rasch , er konnte 4 Tage nach der Embolisation extubiert werden . Die sonographische Kontrolle nach 4 Monaten zeigte eine deutliche Regression des Tumors .

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[ "umlsterm" ]

Neugeborenes is an umlsterm, Geburtsgewicht is an umlsterm, Therapie is an umlsterm, Digitalis is an umlsterm, Diuretika is an umlsterm, Behandlung is an umlsterm, Lebenstag is an umlsterm, Therapie is an umlsterm, Tumorgefaesse is an umlsterm, Patienten is an umlsterm, Tumors is an umlsterm

ZfuerKardiologie.80870832.ger.abstr_task1

Sentence: Wir berichten ueber ein Neugeborenes ( Geburtsgewicht 3660 g ) , welches postpartal wegen eines hepatischen Haemangioendothelioms und dem damit verbundenen arteriovenoesen Shuntvolumen kardiorespiratorisch dekompensierte . Eine Therapie der Herzinsuffizienz mit Digitalis und Diuretika sowie eine Behandlung mit Kortikosteroiden wurde am 1. Lebenstag begonnen , konnte die Symptomatik jedoch nicht verbessern . Aus diesem Grund wurde eine interventionelle Therapie des Haemangioendothelioms mittels Coil-Okklusion der arteriellen Tumorgefaesse durchgefuehrt . Die Symptomatik des Patienten besserte sich daraufhin rasch , er konnte 4 Tage nach der Embolisation extubiert werden . Die sonographische Kontrolle nach 4 Monaten zeigte eine deutliche Regression des Tumors . Instructions: please typing these entity words according to sentence: Neugeborenes, Geburtsgewicht, Therapie, Digitalis, Diuretika, Behandlung, Lebenstag, Therapie, Tumorgefaesse, Patienten, Tumors Options: umlsterm

[ "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

Wir berichten ueber ein Neugeborenes ( Geburtsgewicht 3660 g ) , welches postpartal wegen eines hepatischen Haemangioendothelioms und dem damit verbundenen arteriovenoesen Shuntvolumen kardiorespiratorisch dekompensierte . Eine Therapie der Herzinsuffizienz mit Digitalis und Diuretika sowie eine Behandlung mit Kortikosteroiden wurde am 1. Lebenstag begonnen , konnte die Symptomatik jedoch nicht verbessern . Aus diesem Grund wurde eine interventionelle Therapie des Haemangioendothelioms mittels Coil-Okklusion der arteriellen Tumorgefaesse durchgefuehrt . Die Symptomatik des Patienten besserte sich daraufhin rasch , er konnte 4 Tage nach der Embolisation extubiert werden . Die sonographische Kontrolle nach 4 Monaten zeigte eine deutliche Regression des Tumors .

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[ "umlsterm" ]

Neugeborenes, Geburtsgewicht, Therapie, Digitalis, Diuretika, Behandlung, Lebenstag, Therapie, Tumorgefaesse, Patienten, Tumors

ZfuerKardiologie.80870832.ger.abstr_task2

Sentence: Wir berichten ueber ein Neugeborenes ( Geburtsgewicht 3660 g ) , welches postpartal wegen eines hepatischen Haemangioendothelioms und dem damit verbundenen arteriovenoesen Shuntvolumen kardiorespiratorisch dekompensierte . Eine Therapie der Herzinsuffizienz mit Digitalis und Diuretika sowie eine Behandlung mit Kortikosteroiden wurde am 1. Lebenstag begonnen , konnte die Symptomatik jedoch nicht verbessern . Aus diesem Grund wurde eine interventionelle Therapie des Haemangioendothelioms mittels Coil-Okklusion der arteriellen Tumorgefaesse durchgefuehrt . Die Symptomatik des Patienten besserte sich daraufhin rasch , er konnte 4 Tage nach der Embolisation extubiert werden . Die sonographische Kontrolle nach 4 Monaten zeigte eine deutliche Regression des Tumors . Instructions: please extract entity words from the input sentence

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Wir berichten ueber ein Neugeborenes ( Geburtsgewicht 3660 g ) , welches postpartal wegen eines hepatischen Haemangioendothelioms und dem damit verbundenen arteriovenoesen Shuntvolumen kardiorespiratorisch dekompensierte . Eine Therapie der Herzinsuffizienz mit Digitalis und Diuretika sowie eine Behandlung mit Kortikosteroiden wurde am 1. Lebenstag begonnen , konnte die Symptomatik jedoch nicht verbessern . Aus diesem Grund wurde eine interventionelle Therapie des Haemangioendothelioms mittels Coil-Okklusion der arteriellen Tumorgefaesse durchgefuehrt . Die Symptomatik des Patienten besserte sich daraufhin rasch , er konnte 4 Tage nach der Embolisation extubiert werden . Die sonographische Kontrolle nach 4 Monaten zeigte eine deutliche Regression des Tumors .

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[ "umlsterm" ]

aim is an umlsterm, treatment is an umlsterm, radius fractures is an umlsterm

DerChirurg.90701315.eng.abstr_task0

Sentence: Introduction : The aim of our study was to evaluate external fixation in the treatment of unstable distal radius fractures in a long-term follow-up . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Introduction : The aim of our study was to evaluate external fixation in the treatment of unstable distal radius fractures in a long-term follow-up .

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[ "umlsterm" ]

aim is an umlsterm, treatment is an umlsterm, radius fractures is an umlsterm

DerChirurg.90701315.eng.abstr_task1

Sentence: Introduction : The aim of our study was to evaluate external fixation in the treatment of unstable distal radius fractures in a long-term follow-up . Instructions: please typing these entity words according to sentence: aim, treatment, radius fractures Options: umlsterm

[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Introduction : The aim of our study was to evaluate external fixation in the treatment of unstable distal radius fractures in a long-term follow-up .

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[ "umlsterm" ]

aim, treatment, radius fractures

DerChirurg.90701315.eng.abstr_task2

Sentence: Introduction : The aim of our study was to evaluate external fixation in the treatment of unstable distal radius fractures in a long-term follow-up . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Introduction : The aim of our study was to evaluate external fixation in the treatment of unstable distal radius fractures in a long-term follow-up .

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[ "umlsterm" ]

analgesia is an umlsterm, postoperative is an umlsterm, morbidity is an umlsterm, mortality is an umlsterm, epidural anaesthesia is an umlsterm, pain is an umlsterm, epidural analgesia is an umlsterm, stress is an umlsterm, postoperative is an umlsterm, morbidity is an umlsterm, mortality is an umlsterm, patients is an umlsterm, vascular surgery is an umlsterm, epidural anaesthesia is an umlsterm, postoperative is an umlsterm, hypercoagulability is an umlsterm, patients is an umlsterm, complications is an umlsterm, risk of is an umlsterm, re - operation is an umlsterm, regional anaesthesia is an umlsterm, morbidity is an umlsterm, overall is an umlsterm, mortality is an umlsterm, clinical studies is an umlsterm, finding is an umlsterm, postoperative pain is an umlsterm, surgical is an umlsterm, care is an umlsterm, therapeutic is an umlsterm, patient is an umlsterm, analgesia is an umlsterm, early mobilisation is an umlsterm, enteral feeding is an umlsterm

DerAnaesthesist.7046s187.eng.abstr_task0

Sentence: Effects of anaesthesia and analgesia on postoperative morbidity and mortality remain controversial . Numerous studies have demonstrated that epidural anaesthesia and pain relief by epidural analgesia reduces perioperative stress responses and thus may reduce postoperative morbidity and mortality . In patients undergoing vascular surgery , epidural anaesthesia diminished postoperative hypercoagulability . These patients may benefit from less thromboembolic complications as well as a reduced risk of a re-operation . However , regional anaesthesia does not affect cardiopulmonary morbidity or overall mortality significantly in most clinical studies . One reason for this disappointing finding may be the missing integration of improved postoperative pain relief into general surgical care . A multimodal therapeutic approach , which consists of preoperativ patient information , sufficient analgesia , early mobilisation and enteral feeding , may solve this discrepancy . Therefore , prospective controlled studies are needed to assess the influence of this perioperative approach on outcome . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Effects of anaesthesia and analgesia on postoperative morbidity and mortality remain controversial . Numerous studies have demonstrated that epidural anaesthesia and pain relief by epidural analgesia reduces perioperative stress responses and thus may reduce postoperative morbidity and mortality . In patients undergoing vascular surgery , epidural anaesthesia diminished postoperative hypercoagulability . These patients may benefit from less thromboembolic complications as well as a reduced risk of a re-operation . However , regional anaesthesia does not affect cardiopulmonary morbidity or overall mortality significantly in most clinical studies . One reason for this disappointing finding may be the missing integration of improved postoperative pain relief into general surgical care . A multimodal therapeutic approach , which consists of preoperativ patient information , sufficient analgesia , early mobilisation and enteral feeding , may solve this discrepancy . Therefore , prospective controlled studies are needed to assess the influence of this perioperative approach on outcome .

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[ "umlsterm" ]

analgesia is an umlsterm, postoperative is an umlsterm, morbidity is an umlsterm, mortality is an umlsterm, epidural anaesthesia is an umlsterm, pain is an umlsterm, epidural analgesia is an umlsterm, stress is an umlsterm, postoperative is an umlsterm, morbidity is an umlsterm, mortality is an umlsterm, patients is an umlsterm, vascular surgery is an umlsterm, epidural anaesthesia is an umlsterm, postoperative is an umlsterm, hypercoagulability is an umlsterm, patients is an umlsterm, complications is an umlsterm, risk of is an umlsterm, re - operation is an umlsterm, regional anaesthesia is an umlsterm, morbidity is an umlsterm, overall is an umlsterm, mortality is an umlsterm, clinical studies is an umlsterm, finding is an umlsterm, postoperative pain is an umlsterm, surgical is an umlsterm, care is an umlsterm, therapeutic is an umlsterm, patient is an umlsterm, analgesia is an umlsterm, early mobilisation is an umlsterm, enteral feeding is an umlsterm

DerAnaesthesist.7046s187.eng.abstr_task1

Sentence: Effects of anaesthesia and analgesia on postoperative morbidity and mortality remain controversial . Numerous studies have demonstrated that epidural anaesthesia and pain relief by epidural analgesia reduces perioperative stress responses and thus may reduce postoperative morbidity and mortality . In patients undergoing vascular surgery , epidural anaesthesia diminished postoperative hypercoagulability . These patients may benefit from less thromboembolic complications as well as a reduced risk of a re-operation . However , regional anaesthesia does not affect cardiopulmonary morbidity or overall mortality significantly in most clinical studies . One reason for this disappointing finding may be the missing integration of improved postoperative pain relief into general surgical care . A multimodal therapeutic approach , which consists of preoperativ patient information , sufficient analgesia , early mobilisation and enteral feeding , may solve this discrepancy . Therefore , prospective controlled studies are needed to assess the influence of this perioperative approach on outcome . Instructions: please typing these entity words according to sentence: analgesia, postoperative, morbidity, mortality, epidural anaesthesia, pain, epidural analgesia, stress, postoperative, morbidity, mortality, patients, vascular surgery, epidural anaesthesia, postoperative, hypercoagulability, patients, complications, risk of, re - operation, regional anaesthesia, morbidity, overall, mortality, clinical studies, finding, postoperative pain, surgical, care, therapeutic, patient, analgesia, early mobilisation, enteral feeding Options: umlsterm

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Effects of anaesthesia and analgesia on postoperative morbidity and mortality remain controversial . Numerous studies have demonstrated that epidural anaesthesia and pain relief by epidural analgesia reduces perioperative stress responses and thus may reduce postoperative morbidity and mortality . In patients undergoing vascular surgery , epidural anaesthesia diminished postoperative hypercoagulability . These patients may benefit from less thromboembolic complications as well as a reduced risk of a re-operation . However , regional anaesthesia does not affect cardiopulmonary morbidity or overall mortality significantly in most clinical studies . One reason for this disappointing finding may be the missing integration of improved postoperative pain relief into general surgical care . A multimodal therapeutic approach , which consists of preoperativ patient information , sufficient analgesia , early mobilisation and enteral feeding , may solve this discrepancy . Therefore , prospective controlled studies are needed to assess the influence of this perioperative approach on outcome .

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[ "umlsterm" ]

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DerAnaesthesist.7046s187.eng.abstr_task2

Sentence: Effects of anaesthesia and analgesia on postoperative morbidity and mortality remain controversial . Numerous studies have demonstrated that epidural anaesthesia and pain relief by epidural analgesia reduces perioperative stress responses and thus may reduce postoperative morbidity and mortality . In patients undergoing vascular surgery , epidural anaesthesia diminished postoperative hypercoagulability . These patients may benefit from less thromboembolic complications as well as a reduced risk of a re-operation . However , regional anaesthesia does not affect cardiopulmonary morbidity or overall mortality significantly in most clinical studies . One reason for this disappointing finding may be the missing integration of improved postoperative pain relief into general surgical care . A multimodal therapeutic approach , which consists of preoperativ patient information , sufficient analgesia , early mobilisation and enteral feeding , may solve this discrepancy . Therefore , prospective controlled studies are needed to assess the influence of this perioperative approach on outcome . Instructions: please extract entity words from the input sentence

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Effects of anaesthesia and analgesia on postoperative morbidity and mortality remain controversial . Numerous studies have demonstrated that epidural anaesthesia and pain relief by epidural analgesia reduces perioperative stress responses and thus may reduce postoperative morbidity and mortality . In patients undergoing vascular surgery , epidural anaesthesia diminished postoperative hypercoagulability . These patients may benefit from less thromboembolic complications as well as a reduced risk of a re-operation . However , regional anaesthesia does not affect cardiopulmonary morbidity or overall mortality significantly in most clinical studies . One reason for this disappointing finding may be the missing integration of improved postoperative pain relief into general surgical care . A multimodal therapeutic approach , which consists of preoperativ patient information , sufficient analgesia , early mobilisation and enteral feeding , may solve this discrepancy . Therefore , prospective controlled studies are needed to assess the influence of this perioperative approach on outcome .

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[ "umlsterm" ]

glucagon - like peptide-1 is a GENE-Y

23203941_task0

Sentence: Synthesis, characterization and pharmacodynamics of vitamin-B(12)-conjugated glucagon-like peptide-1. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O" ]

Synthesis, characterization and pharmacodynamics of vitamin-B(12)-conjugated glucagon-like peptide-1.

[ "Synthesis", ",", "characterization", "and", "pharmacodynamics", "of", "vitamin", "-", "B(12)-conjugated", "glucagon", "-", "like", "peptide-1", "." ]

[ "GENE-Y", "CHEMICAL" ]

glucagon - like peptide-1 is a GENE-Y

23203941_task1

Sentence: Synthesis, characterization and pharmacodynamics of vitamin-B(12)-conjugated glucagon-like peptide-1. Instructions: please typing these entity words according to sentence: glucagon - like peptide-1 Options: GENE-Y

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O" ]

Synthesis, characterization and pharmacodynamics of vitamin-B(12)-conjugated glucagon-like peptide-1.

[ "Synthesis", ",", "characterization", "and", "pharmacodynamics", "of", "vitamin", "-", "B(12)-conjugated", "glucagon", "-", "like", "peptide-1", "." ]

[ "GENE-Y", "CHEMICAL" ]

glucagon - like peptide-1

23203941_task2

Sentence: Synthesis, characterization and pharmacodynamics of vitamin-B(12)-conjugated glucagon-like peptide-1. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O" ]

Synthesis, characterization and pharmacodynamics of vitamin-B(12)-conjugated glucagon-like peptide-1.

[ "Synthesis", ",", "characterization", "and", "pharmacodynamics", "of", "vitamin", "-", "B(12)-conjugated", "glucagon", "-", "like", "peptide-1", "." ]

[ "GENE-Y", "CHEMICAL" ]

antibiotics is a GROUP, methotrexate is a DRUG, pyrimethamine is a DRUG, folic acid is a DRUG, vitamin B12 is a DRUG, Colchicine is a DRUG, para - aminosalicylic acid is a DRUG, alcohol is a DRUG, vitamin B12 is a DRUG

Cyanocobalamin_ddi_task0

Sentence: Persons taking most antibiotics, methotrexate and pyrimethamine invalidate folic acid and vitamin B12 diagnostic blood assays. Colchicine para-aminosalicylic acid and heavy alcohol intake for longer than 2 weeks may produce malabsorption of vitamin B12. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GROUP, DRUG

[ "O", "O", "O", "B-GROUP", "O", "B-DRUG", "O", "B-DRUG", "O", "B-DRUG", "I-DRUG", "O", "B-DRUG", "I-DRUG", "O", "O", "O", "O", "B-DRUG", "B-DRUG", "I-DRUG", "I-DRUG", "I-DRUG", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "I-DRUG", "O" ]

Persons taking most antibiotics, methotrexate and pyrimethamine invalidate folic acid and vitamin B12 diagnostic blood assays. Colchicine para-aminosalicylic acid and heavy alcohol intake for longer than 2 weeks may produce malabsorption of vitamin B12.

[ "Persons", "taking", "most", "antibiotics", ",", "methotrexate", "and", "pyrimethamine", "invalidate", "folic", "acid", "and", "vitamin", "B12", "diagnostic", "blood", "assays", ".", "Colchicine", "para", "-", "aminosalicylic", "acid", "and", "heavy", "alcohol", "intake", "for", "longer", "than", "2", "weeks", "may", "produce", "malabsorption", "of", "vitamin", "B12", "." ]

[ "DRUG", "GROUP" ]

antibiotics is a GROUP, methotrexate is a DRUG, pyrimethamine is a DRUG, folic acid is a DRUG, vitamin B12 is a DRUG, Colchicine is a DRUG, para - aminosalicylic acid is a DRUG, alcohol is a DRUG, vitamin B12 is a DRUG

Cyanocobalamin_ddi_task1

Sentence: Persons taking most antibiotics, methotrexate and pyrimethamine invalidate folic acid and vitamin B12 diagnostic blood assays. Colchicine para-aminosalicylic acid and heavy alcohol intake for longer than 2 weeks may produce malabsorption of vitamin B12. Instructions: please typing these entity words according to sentence: antibiotics, methotrexate, pyrimethamine, folic acid, vitamin B12, Colchicine, para - aminosalicylic acid, alcohol, vitamin B12 Options: GROUP, DRUG

[ "O", "O", "O", "B-GROUP", "O", "B-DRUG", "O", "B-DRUG", "O", "B-DRUG", "I-DRUG", "O", "B-DRUG", "I-DRUG", "O", "O", "O", "O", "B-DRUG", "B-DRUG", "I-DRUG", "I-DRUG", "I-DRUG", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "I-DRUG", "O" ]

Persons taking most antibiotics, methotrexate and pyrimethamine invalidate folic acid and vitamin B12 diagnostic blood assays. Colchicine para-aminosalicylic acid and heavy alcohol intake for longer than 2 weeks may produce malabsorption of vitamin B12.

[ "Persons", "taking", "most", "antibiotics", ",", "methotrexate", "and", "pyrimethamine", "invalidate", "folic", "acid", "and", "vitamin", "B12", "diagnostic", "blood", "assays", ".", "Colchicine", "para", "-", "aminosalicylic", "acid", "and", "heavy", "alcohol", "intake", "for", "longer", "than", "2", "weeks", "may", "produce", "malabsorption", "of", "vitamin", "B12", "." ]

[ "DRUG", "GROUP" ]

antibiotics, methotrexate, pyrimethamine, folic acid, vitamin B12, Colchicine, para - aminosalicylic acid, alcohol, vitamin B12

Cyanocobalamin_ddi_task2

Sentence: Persons taking most antibiotics, methotrexate and pyrimethamine invalidate folic acid and vitamin B12 diagnostic blood assays. Colchicine para-aminosalicylic acid and heavy alcohol intake for longer than 2 weeks may produce malabsorption of vitamin B12. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "B-GROUP", "O", "B-DRUG", "O", "B-DRUG", "O", "B-DRUG", "I-DRUG", "O", "B-DRUG", "I-DRUG", "O", "O", "O", "O", "B-DRUG", "B-DRUG", "I-DRUG", "I-DRUG", "I-DRUG", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "I-DRUG", "O" ]

Persons taking most antibiotics, methotrexate and pyrimethamine invalidate folic acid and vitamin B12 diagnostic blood assays. Colchicine para-aminosalicylic acid and heavy alcohol intake for longer than 2 weeks may produce malabsorption of vitamin B12.

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[ "DRUG", "GROUP" ]

Duodenopankreatektomie is an umlsterm, Duodenopankreatektomie is an umlsterm, Patienten is an umlsterm, Morbiditaet is an umlsterm, Prognose is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Tumornachsorge is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Operationsmethode is an umlsterm, Komplikationen is an umlsterm, Standardoperation is an umlsterm, Patienten is an umlsterm, Operationsmethode is an umlsterm, Prognose is an umlsterm

DerChirurg.70681262.ger.abstr_task0

Sentence: Zusammenfassung . Anhand einer Studie mit prospektiv erhobenen Daten wurde die Wertigkeit der pyloruserhaltenden partiellen Duodenopankreatektomie ( PPPD ) im Vergleich zur partiellen Duodenopankreatektomie nach Whipple ( PD ) bei Patienten mit einem duktalen Pankreascarcinom bzgl. postoperativer Morbiditaet , Letalitaet und Prognose verglichen . Von Mai 1990 bis April 1995 gingen 130 Patienten in die Studie ein , wobei 61 eine PD bzw. 69 Patienten eine PPPD erhielten . Alle Patienten wurden in 6monatigen Abstaenden im Rahmen der Tumornachsorge nachuntersucht . Das mediane Nachuntersuchungsintervall lag bei den Patienten bei 36 Monaten ; die Ueberlebenskurven wurden nach Kaplan-Meier errechnet . Es zeigte sich , dass die PPPD bei Patienten mit duktalem Pankreaskopfcarcinom ohne Infiltration des Duodenums die technisch einfachere , blutsparendere , schnellere Operationsmethode ist , die zu keinen erhoehten perioperativen Komplikationen fuehrt . Magenentleerungsstoerungen waren allenfalls temporaer und unterschieden sich nicht signifikant von der Standardoperation nach Whipple ( PD ) . Die mediane Ueberlebenszeit der Patienten in der PD-Gruppe lag in bezug auf alle Stadien bei 10,8 Monaten , in der PPPD-Gruppe bei 21 Monaten . Dieser an sich signifikante Unterschied erklaert sich jedoch aus der etwas unterschiedlichen Verteilung der UICC-Stadien in beiden Behandlungsgruppen . Betrachtet man das haeufigste Stadium ( UICC-Stadium III ) , so konnte kein Unterschied in den medianen Ueberlebenszeiten zwischen den Gruppen festgestellt werden : Sie liegen bei 10,1 bzw. 11,2 Monaten . Die PPPD stellt somit eine radikale Operationsmethode dar , die die Prognose der Erkrankung nicht verschlechtert . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Zusammenfassung . Anhand einer Studie mit prospektiv erhobenen Daten wurde die Wertigkeit der pyloruserhaltenden partiellen Duodenopankreatektomie ( PPPD ) im Vergleich zur partiellen Duodenopankreatektomie nach Whipple ( PD ) bei Patienten mit einem duktalen Pankreascarcinom bzgl. postoperativer Morbiditaet , Letalitaet und Prognose verglichen . Von Mai 1990 bis April 1995 gingen 130 Patienten in die Studie ein , wobei 61 eine PD bzw. 69 Patienten eine PPPD erhielten . Alle Patienten wurden in 6monatigen Abstaenden im Rahmen der Tumornachsorge nachuntersucht . Das mediane Nachuntersuchungsintervall lag bei den Patienten bei 36 Monaten ; die Ueberlebenskurven wurden nach Kaplan-Meier errechnet . Es zeigte sich , dass die PPPD bei Patienten mit duktalem Pankreaskopfcarcinom ohne Infiltration des Duodenums die technisch einfachere , blutsparendere , schnellere Operationsmethode ist , die zu keinen erhoehten perioperativen Komplikationen fuehrt . Magenentleerungsstoerungen waren allenfalls temporaer und unterschieden sich nicht signifikant von der Standardoperation nach Whipple ( PD ) . Die mediane Ueberlebenszeit der Patienten in der PD-Gruppe lag in bezug auf alle Stadien bei 10,8 Monaten , in der PPPD-Gruppe bei 21 Monaten . Dieser an sich signifikante Unterschied erklaert sich jedoch aus der etwas unterschiedlichen Verteilung der UICC-Stadien in beiden Behandlungsgruppen . Betrachtet man das haeufigste Stadium ( UICC-Stadium III ) , so konnte kein Unterschied in den medianen Ueberlebenszeiten zwischen den Gruppen festgestellt werden : Sie liegen bei 10,1 bzw. 11,2 Monaten . Die PPPD stellt somit eine radikale Operationsmethode dar , die die Prognose der Erkrankung nicht verschlechtert .

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[ "umlsterm" ]

Duodenopankreatektomie is an umlsterm, Duodenopankreatektomie is an umlsterm, Patienten is an umlsterm, Morbiditaet is an umlsterm, Prognose is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Tumornachsorge is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Operationsmethode is an umlsterm, Komplikationen is an umlsterm, Standardoperation is an umlsterm, Patienten is an umlsterm, Operationsmethode is an umlsterm, Prognose is an umlsterm

DerChirurg.70681262.ger.abstr_task1

Sentence: Zusammenfassung . Anhand einer Studie mit prospektiv erhobenen Daten wurde die Wertigkeit der pyloruserhaltenden partiellen Duodenopankreatektomie ( PPPD ) im Vergleich zur partiellen Duodenopankreatektomie nach Whipple ( PD ) bei Patienten mit einem duktalen Pankreascarcinom bzgl. postoperativer Morbiditaet , Letalitaet und Prognose verglichen . Von Mai 1990 bis April 1995 gingen 130 Patienten in die Studie ein , wobei 61 eine PD bzw. 69 Patienten eine PPPD erhielten . Alle Patienten wurden in 6monatigen Abstaenden im Rahmen der Tumornachsorge nachuntersucht . Das mediane Nachuntersuchungsintervall lag bei den Patienten bei 36 Monaten ; die Ueberlebenskurven wurden nach Kaplan-Meier errechnet . Es zeigte sich , dass die PPPD bei Patienten mit duktalem Pankreaskopfcarcinom ohne Infiltration des Duodenums die technisch einfachere , blutsparendere , schnellere Operationsmethode ist , die zu keinen erhoehten perioperativen Komplikationen fuehrt . Magenentleerungsstoerungen waren allenfalls temporaer und unterschieden sich nicht signifikant von der Standardoperation nach Whipple ( PD ) . Die mediane Ueberlebenszeit der Patienten in der PD-Gruppe lag in bezug auf alle Stadien bei 10,8 Monaten , in der PPPD-Gruppe bei 21 Monaten . Dieser an sich signifikante Unterschied erklaert sich jedoch aus der etwas unterschiedlichen Verteilung der UICC-Stadien in beiden Behandlungsgruppen . Betrachtet man das haeufigste Stadium ( UICC-Stadium III ) , so konnte kein Unterschied in den medianen Ueberlebenszeiten zwischen den Gruppen festgestellt werden : Sie liegen bei 10,1 bzw. 11,2 Monaten . Die PPPD stellt somit eine radikale Operationsmethode dar , die die Prognose der Erkrankung nicht verschlechtert . Instructions: please typing these entity words according to sentence: Duodenopankreatektomie, Duodenopankreatektomie, Patienten, Morbiditaet, Prognose, Patienten, Patienten, Patienten, Tumornachsorge, Patienten, Patienten, Operationsmethode, Komplikationen, Standardoperation, Patienten, Operationsmethode, Prognose Options: umlsterm

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Zusammenfassung . Anhand einer Studie mit prospektiv erhobenen Daten wurde die Wertigkeit der pyloruserhaltenden partiellen Duodenopankreatektomie ( PPPD ) im Vergleich zur partiellen Duodenopankreatektomie nach Whipple ( PD ) bei Patienten mit einem duktalen Pankreascarcinom bzgl. postoperativer Morbiditaet , Letalitaet und Prognose verglichen . Von Mai 1990 bis April 1995 gingen 130 Patienten in die Studie ein , wobei 61 eine PD bzw. 69 Patienten eine PPPD erhielten . Alle Patienten wurden in 6monatigen Abstaenden im Rahmen der Tumornachsorge nachuntersucht . Das mediane Nachuntersuchungsintervall lag bei den Patienten bei 36 Monaten ; die Ueberlebenskurven wurden nach Kaplan-Meier errechnet . Es zeigte sich , dass die PPPD bei Patienten mit duktalem Pankreaskopfcarcinom ohne Infiltration des Duodenums die technisch einfachere , blutsparendere , schnellere Operationsmethode ist , die zu keinen erhoehten perioperativen Komplikationen fuehrt . Magenentleerungsstoerungen waren allenfalls temporaer und unterschieden sich nicht signifikant von der Standardoperation nach Whipple ( PD ) . Die mediane Ueberlebenszeit der Patienten in der PD-Gruppe lag in bezug auf alle Stadien bei 10,8 Monaten , in der PPPD-Gruppe bei 21 Monaten . Dieser an sich signifikante Unterschied erklaert sich jedoch aus der etwas unterschiedlichen Verteilung der UICC-Stadien in beiden Behandlungsgruppen . Betrachtet man das haeufigste Stadium ( UICC-Stadium III ) , so konnte kein Unterschied in den medianen Ueberlebenszeiten zwischen den Gruppen festgestellt werden : Sie liegen bei 10,1 bzw. 11,2 Monaten . Die PPPD stellt somit eine radikale Operationsmethode dar , die die Prognose der Erkrankung nicht verschlechtert .

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[ "umlsterm" ]

Duodenopankreatektomie, Duodenopankreatektomie, Patienten, Morbiditaet, Prognose, Patienten, Patienten, Patienten, Tumornachsorge, Patienten, Patienten, Operationsmethode, Komplikationen, Standardoperation, Patienten, Operationsmethode, Prognose

DerChirurg.70681262.ger.abstr_task2

Sentence: Zusammenfassung . Anhand einer Studie mit prospektiv erhobenen Daten wurde die Wertigkeit der pyloruserhaltenden partiellen Duodenopankreatektomie ( PPPD ) im Vergleich zur partiellen Duodenopankreatektomie nach Whipple ( PD ) bei Patienten mit einem duktalen Pankreascarcinom bzgl. postoperativer Morbiditaet , Letalitaet und Prognose verglichen . Von Mai 1990 bis April 1995 gingen 130 Patienten in die Studie ein , wobei 61 eine PD bzw. 69 Patienten eine PPPD erhielten . Alle Patienten wurden in 6monatigen Abstaenden im Rahmen der Tumornachsorge nachuntersucht . Das mediane Nachuntersuchungsintervall lag bei den Patienten bei 36 Monaten ; die Ueberlebenskurven wurden nach Kaplan-Meier errechnet . Es zeigte sich , dass die PPPD bei Patienten mit duktalem Pankreaskopfcarcinom ohne Infiltration des Duodenums die technisch einfachere , blutsparendere , schnellere Operationsmethode ist , die zu keinen erhoehten perioperativen Komplikationen fuehrt . Magenentleerungsstoerungen waren allenfalls temporaer und unterschieden sich nicht signifikant von der Standardoperation nach Whipple ( PD ) . Die mediane Ueberlebenszeit der Patienten in der PD-Gruppe lag in bezug auf alle Stadien bei 10,8 Monaten , in der PPPD-Gruppe bei 21 Monaten . Dieser an sich signifikante Unterschied erklaert sich jedoch aus der etwas unterschiedlichen Verteilung der UICC-Stadien in beiden Behandlungsgruppen . Betrachtet man das haeufigste Stadium ( UICC-Stadium III ) , so konnte kein Unterschied in den medianen Ueberlebenszeiten zwischen den Gruppen festgestellt werden : Sie liegen bei 10,1 bzw. 11,2 Monaten . Die PPPD stellt somit eine radikale Operationsmethode dar , die die Prognose der Erkrankung nicht verschlechtert . Instructions: please extract entity words from the input sentence

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Zusammenfassung . Anhand einer Studie mit prospektiv erhobenen Daten wurde die Wertigkeit der pyloruserhaltenden partiellen Duodenopankreatektomie ( PPPD ) im Vergleich zur partiellen Duodenopankreatektomie nach Whipple ( PD ) bei Patienten mit einem duktalen Pankreascarcinom bzgl. postoperativer Morbiditaet , Letalitaet und Prognose verglichen . Von Mai 1990 bis April 1995 gingen 130 Patienten in die Studie ein , wobei 61 eine PD bzw. 69 Patienten eine PPPD erhielten . Alle Patienten wurden in 6monatigen Abstaenden im Rahmen der Tumornachsorge nachuntersucht . Das mediane Nachuntersuchungsintervall lag bei den Patienten bei 36 Monaten ; die Ueberlebenskurven wurden nach Kaplan-Meier errechnet . Es zeigte sich , dass die PPPD bei Patienten mit duktalem Pankreaskopfcarcinom ohne Infiltration des Duodenums die technisch einfachere , blutsparendere , schnellere Operationsmethode ist , die zu keinen erhoehten perioperativen Komplikationen fuehrt . Magenentleerungsstoerungen waren allenfalls temporaer und unterschieden sich nicht signifikant von der Standardoperation nach Whipple ( PD ) . Die mediane Ueberlebenszeit der Patienten in der PD-Gruppe lag in bezug auf alle Stadien bei 10,8 Monaten , in der PPPD-Gruppe bei 21 Monaten . Dieser an sich signifikante Unterschied erklaert sich jedoch aus der etwas unterschiedlichen Verteilung der UICC-Stadien in beiden Behandlungsgruppen . Betrachtet man das haeufigste Stadium ( UICC-Stadium III ) , so konnte kein Unterschied in den medianen Ueberlebenszeiten zwischen den Gruppen festgestellt werden : Sie liegen bei 10,1 bzw. 11,2 Monaten . Die PPPD stellt somit eine radikale Operationsmethode dar , die die Prognose der Erkrankung nicht verschlechtert .

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[ "umlsterm" ]

metastasized melanoma is a DISEASE, metastatic melanoma is a DISEASE, alopecia is a ADVERSE, peripheral neuropathy is a ADVERSE, melanoma is a DISEASE

example-375_task0

Sentence: Adjuvant treatment with vindesine in comparison to observation alone in patients with metastasized melanoma after complete metastasectomy: a randomized multicenter trial of the German Dermatologic Cooperative Oncology Group. To evaluate the efficacy and safety of vindesine in patients with metastatic melanoma after complete metastasectomy. One hundred and forty-two patients with metastatic spread to regional sites, lymph nodes, and distant sites after complete metastasectomy were randomized to receive either treatment with vindesine for 2 years or observation alone. Vindesine 3 mg/m intravenously was administered biweekly for the first 26 weeks following 3-week intervals for an additional 26 weeks and thereafter every 4 weeks for 52 weeks. One hundred and thirty-nine patients were eligible for intent-to-treat analysis. Median follow-up time was 46 months. Median recurrence free survival was 7.9 months in the vindesine group and 7.6 months in the observational group (P=0.40). Three-year overall survival rate was 54.9% (37 patients) for patients receiving vindesine in comparison to 43.6% (31 patients) in the observation arm (P=0.07). No grade IV toxicity was observed. The two major side effects in the vindesine group were alopecia and peripheral neuropathy. Ten patients went off treatment because of grade III toxicity. Adjuvant treatment with vindesine did not significantly prolong disease free or overall survival in high-risk melanoma patients. Thus, this randomized trial did not confirm earlier reports of beneficial effects of adjuvant vindesine and can therefore not be recommended. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: ADVERSE, DISEASE

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Adjuvant treatment with vindesine in comparison to observation alone in patients with metastasized melanoma after complete metastasectomy: a randomized multicenter trial of the German Dermatologic Cooperative Oncology Group. To evaluate the efficacy and safety of vindesine in patients with metastatic melanoma after complete metastasectomy. One hundred and forty-two patients with metastatic spread to regional sites, lymph nodes, and distant sites after complete metastasectomy were randomized to receive either treatment with vindesine for 2 years or observation alone. Vindesine 3 mg/m intravenously was administered biweekly for the first 26 weeks following 3-week intervals for an additional 26 weeks and thereafter every 4 weeks for 52 weeks. One hundred and thirty-nine patients were eligible for intent-to-treat analysis. Median follow-up time was 46 months. Median recurrence free survival was 7.9 months in the vindesine group and 7.6 months in the observational group (P=0.40). Three-year overall survival rate was 54.9% (37 patients) for patients receiving vindesine in comparison to 43.6% (31 patients) in the observation arm (P=0.07). No grade IV toxicity was observed. The two major side effects in the vindesine group were alopecia and peripheral neuropathy. Ten patients went off treatment because of grade III toxicity. Adjuvant treatment with vindesine did not significantly prolong disease free or overall survival in high-risk melanoma patients. Thus, this randomized trial did not confirm earlier reports of beneficial effects of adjuvant vindesine and can therefore not be recommended.

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[ "DISEASE", "ADVERSE" ]

metastasized melanoma is a DISEASE, metastatic melanoma is a DISEASE, alopecia is a ADVERSE, peripheral neuropathy is a ADVERSE, melanoma is a DISEASE

example-375_task1

Sentence: Adjuvant treatment with vindesine in comparison to observation alone in patients with metastasized melanoma after complete metastasectomy: a randomized multicenter trial of the German Dermatologic Cooperative Oncology Group. To evaluate the efficacy and safety of vindesine in patients with metastatic melanoma after complete metastasectomy. One hundred and forty-two patients with metastatic spread to regional sites, lymph nodes, and distant sites after complete metastasectomy were randomized to receive either treatment with vindesine for 2 years or observation alone. Vindesine 3 mg/m intravenously was administered biweekly for the first 26 weeks following 3-week intervals for an additional 26 weeks and thereafter every 4 weeks for 52 weeks. One hundred and thirty-nine patients were eligible for intent-to-treat analysis. Median follow-up time was 46 months. Median recurrence free survival was 7.9 months in the vindesine group and 7.6 months in the observational group (P=0.40). Three-year overall survival rate was 54.9% (37 patients) for patients receiving vindesine in comparison to 43.6% (31 patients) in the observation arm (P=0.07). No grade IV toxicity was observed. The two major side effects in the vindesine group were alopecia and peripheral neuropathy. Ten patients went off treatment because of grade III toxicity. Adjuvant treatment with vindesine did not significantly prolong disease free or overall survival in high-risk melanoma patients. Thus, this randomized trial did not confirm earlier reports of beneficial effects of adjuvant vindesine and can therefore not be recommended. Instructions: please typing these entity words according to sentence: metastasized melanoma, metastatic melanoma, alopecia, peripheral neuropathy, melanoma Options: ADVERSE, DISEASE

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DISEASE", "I-DISEASE", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DISEASE", "I-DISEASE", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-ADVERSE", "O", "B-ADVERSE", "I-ADVERSE", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DISEASE", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Adjuvant treatment with vindesine in comparison to observation alone in patients with metastasized melanoma after complete metastasectomy: a randomized multicenter trial of the German Dermatologic Cooperative Oncology Group. To evaluate the efficacy and safety of vindesine in patients with metastatic melanoma after complete metastasectomy. One hundred and forty-two patients with metastatic spread to regional sites, lymph nodes, and distant sites after complete metastasectomy were randomized to receive either treatment with vindesine for 2 years or observation alone. Vindesine 3 mg/m intravenously was administered biweekly for the first 26 weeks following 3-week intervals for an additional 26 weeks and thereafter every 4 weeks for 52 weeks. One hundred and thirty-nine patients were eligible for intent-to-treat analysis. Median follow-up time was 46 months. Median recurrence free survival was 7.9 months in the vindesine group and 7.6 months in the observational group (P=0.40). Three-year overall survival rate was 54.9% (37 patients) for patients receiving vindesine in comparison to 43.6% (31 patients) in the observation arm (P=0.07). No grade IV toxicity was observed. The two major side effects in the vindesine group were alopecia and peripheral neuropathy. Ten patients went off treatment because of grade III toxicity. Adjuvant treatment with vindesine did not significantly prolong disease free or overall survival in high-risk melanoma patients. Thus, this randomized trial did not confirm earlier reports of beneficial effects of adjuvant vindesine and can therefore not be recommended.

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[ "DISEASE", "ADVERSE" ]

metastasized melanoma, metastatic melanoma, alopecia, peripheral neuropathy, melanoma

example-375_task2

Sentence: Adjuvant treatment with vindesine in comparison to observation alone in patients with metastasized melanoma after complete metastasectomy: a randomized multicenter trial of the German Dermatologic Cooperative Oncology Group. To evaluate the efficacy and safety of vindesine in patients with metastatic melanoma after complete metastasectomy. One hundred and forty-two patients with metastatic spread to regional sites, lymph nodes, and distant sites after complete metastasectomy were randomized to receive either treatment with vindesine for 2 years or observation alone. Vindesine 3 mg/m intravenously was administered biweekly for the first 26 weeks following 3-week intervals for an additional 26 weeks and thereafter every 4 weeks for 52 weeks. One hundred and thirty-nine patients were eligible for intent-to-treat analysis. Median follow-up time was 46 months. Median recurrence free survival was 7.9 months in the vindesine group and 7.6 months in the observational group (P=0.40). Three-year overall survival rate was 54.9% (37 patients) for patients receiving vindesine in comparison to 43.6% (31 patients) in the observation arm (P=0.07). No grade IV toxicity was observed. The two major side effects in the vindesine group were alopecia and peripheral neuropathy. Ten patients went off treatment because of grade III toxicity. Adjuvant treatment with vindesine did not significantly prolong disease free or overall survival in high-risk melanoma patients. Thus, this randomized trial did not confirm earlier reports of beneficial effects of adjuvant vindesine and can therefore not be recommended. Instructions: please extract entity words from the input sentence

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Adjuvant treatment with vindesine in comparison to observation alone in patients with metastasized melanoma after complete metastasectomy: a randomized multicenter trial of the German Dermatologic Cooperative Oncology Group. To evaluate the efficacy and safety of vindesine in patients with metastatic melanoma after complete metastasectomy. One hundred and forty-two patients with metastatic spread to regional sites, lymph nodes, and distant sites after complete metastasectomy were randomized to receive either treatment with vindesine for 2 years or observation alone. Vindesine 3 mg/m intravenously was administered biweekly for the first 26 weeks following 3-week intervals for an additional 26 weeks and thereafter every 4 weeks for 52 weeks. One hundred and thirty-nine patients were eligible for intent-to-treat analysis. Median follow-up time was 46 months. Median recurrence free survival was 7.9 months in the vindesine group and 7.6 months in the observational group (P=0.40). Three-year overall survival rate was 54.9% (37 patients) for patients receiving vindesine in comparison to 43.6% (31 patients) in the observation arm (P=0.07). No grade IV toxicity was observed. The two major side effects in the vindesine group were alopecia and peripheral neuropathy. Ten patients went off treatment because of grade III toxicity. Adjuvant treatment with vindesine did not significantly prolong disease free or overall survival in high-risk melanoma patients. Thus, this randomized trial did not confirm earlier reports of beneficial effects of adjuvant vindesine and can therefore not be recommended.

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[ "DISEASE", "ADVERSE" ]

molsidomine is a compound, nitric oxide is a compound, HIF-1alpha is a protein

DS.d1141_task0

Sentence: This study was designed to determine the effect of molsidomine (MO), a precursor of nitric oxide (NO) donor, on hypoxia inducible factor alpha (HIF-1alpha) and Sonic hedgehog (Shh) levels considered to be involved in the development of testes ischemia/reperfusion (I-R) injury. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

This study was designed to determine the effect of molsidomine (MO), a precursor of nitric oxide (NO) donor, on hypoxia inducible factor alpha (HIF-1alpha) and Sonic hedgehog (Shh) levels considered to be involved in the development of testes ischemia/reperfusion (I-R) injury.

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[ "compound", "protein" ]

molsidomine is a compound, nitric oxide is a compound, HIF-1alpha is a protein

DS.d1141_task1

Sentence: This study was designed to determine the effect of molsidomine (MO), a precursor of nitric oxide (NO) donor, on hypoxia inducible factor alpha (HIF-1alpha) and Sonic hedgehog (Shh) levels considered to be involved in the development of testes ischemia/reperfusion (I-R) injury. Instructions: please typing these entity words according to sentence: molsidomine, nitric oxide, HIF-1alpha Options: compound, protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

This study was designed to determine the effect of molsidomine (MO), a precursor of nitric oxide (NO) donor, on hypoxia inducible factor alpha (HIF-1alpha) and Sonic hedgehog (Shh) levels considered to be involved in the development of testes ischemia/reperfusion (I-R) injury.

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[ "compound", "protein" ]

molsidomine, nitric oxide, HIF-1alpha

DS.d1141_task2

Sentence: This study was designed to determine the effect of molsidomine (MO), a precursor of nitric oxide (NO) donor, on hypoxia inducible factor alpha (HIF-1alpha) and Sonic hedgehog (Shh) levels considered to be involved in the development of testes ischemia/reperfusion (I-R) injury. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

This study was designed to determine the effect of molsidomine (MO), a precursor of nitric oxide (NO) donor, on hypoxia inducible factor alpha (HIF-1alpha) and Sonic hedgehog (Shh) levels considered to be involved in the development of testes ischemia/reperfusion (I-R) injury.

[ "This", "study", "was", "designed", "to", "determine", "the", "effect", "of", "molsidomine", "(", "MO", ")", ",", "a", "precursor", "of", "nitric", "oxide", "(", "NO", ")", "donor", ",", "on", "hypoxia", "inducible", "factor", "alpha", "(", "HIF-1alpha", ")", "and", "Sonic", "hedgehog", "(", "Shh", ")", "levels", "considered", "to", "be", "involved", "in", "the", "development", "of", "testes", "ischemia", "/", "reperfusion", "(", "I", "-", "R", ")", "injury", "." ]

[ "compound", "protein" ]

Laryngoscopy is an umlsterm, postoperative is an umlsterm, dysfunction is an umlsterm, temporomandibular joint is an umlsterm, TMJ is an umlsterm, TMJ is an umlsterm, patients is an umlsterm, muscles is an umlsterm, exact is an umlsterm, TMJ is an umlsterm, movements is an umlsterm, method is an umlsterm, TMJ is an umlsterm, movements is an umlsterm, intubation is an umlsterm, electronic is an umlsterm, axiography is an umlsterm, diagnostic is an umlsterm, monitor is an umlsterm, TMJ is an umlsterm, movements is an umlsterm, dentistry is an umlsterm, axis is an umlsterm, plates is an umlsterm, patient is an umlsterm, TMJ is an umlsterm, movement is an umlsterm, mouth is an umlsterm, farward is an umlsterm, incisor is an umlsterm, distance is an umlsterm, plates is an umlsterm, TMJ is an umlsterm, skull - mounted is an umlsterm, plate is an umlsterm, tips is an umlsterm, electronic is an umlsterm, plates is an umlsterm, mandible is an umlsterm, face is an umlsterm, teeth is an umlsterm, face is an umlsterm, patient is an umlsterm, mask is an umlsterm, ventilation is an umlsterm, movement is an umlsterm, laryngoscope is an umlsterm, intubation is an umlsterm, projections is an umlsterm, operating theatre is an umlsterm, endotracheal intubation is an umlsterm, head is an umlsterm, ethics committee is an umlsterm, male is an umlsterm, patients is an umlsterm, ASA is an umlsterm, Mallampati is an umlsterm, limb is an umlsterm, surgery is an umlsterm, intubation is an umlsterm, suxamethonium is an umlsterm, intubation is an umlsterm, vecuronium is an umlsterm, intubation is an umlsterm, suxamethonium is an umlsterm, intubation is an umlsterm, vecuronium is an umlsterm, Intubation is an umlsterm, injection is an umlsterm, findings is an umlsterm, movements is an umlsterm, mandible is an umlsterm, mouth is an umlsterm, dysfunction is an umlsterm, TMJ is an umlsterm, pain is an umlsterm, sensation is an umlsterm, TMJ is an umlsterm, intubations is an umlsterm, TMJ is an umlsterm, movements is an umlsterm, intubation is an umlsterm, method is an umlsterm, TMJ is an umlsterm, movements is an umlsterm, endotracheal intubation is an umlsterm, time is an umlsterm, techniques is an umlsterm, instruments is an umlsterm, intubation is an umlsterm, movements is an umlsterm, endotracheal intubation is an umlsterm

DerAnaesthesist.60450907.eng.abstr_task0

Sentence: Laryngoscopy causes temporary postoperative dysfunction of the temporomandibular joint ( TMJ ) : during iatrogenic TMJ manipulation in anaesthetised patients , the TMJs have lost the protection afforded by the tone of the surrounding muscles . Thus far , the exact type and extent of TMJ movements have not been known . The purpose of this study was to develop a method to visualise and assess TMJ movements during intubation by means of electronic axiography , a diagnostic monitor of TMJ movements used in dentistry : registration of the hinge axis ( HA ) as an equivalent of the condylar paths on extra-oral sagittally mounted , parallel plates . The HA is individually defined in each patient by the pure , rotating TMJ movement during initial mouth opening ( no farward gliding of the condyles , incisor distance up to 10 mm ) . The parallel plates are placed in the TMJ region in the skull-mounted plate bow ; both registration tips ( " drawing " the HA tracings on the electronic plates ) are connected to the mandible by a face bow , paraocclusally fixed to the teeth . The face bow is individually shaped for each patient to allow mask ventilation and free movement of the laryngoscope during intubation . HA tracings are registered and calculated for both sides independently every 24 ms with the SAM/Klett system and presented on sagittal and frontal projections . In the operating theatre , the active mouth-opening traces ( MOT ) are registered first and the passive endotracheal intubation traces ( EIT ) after induction of anaesthesia ( same head position ) . With informed consent and approval by the ethics committee of the Landesaerztekammer Rheinland-Pfalz , 40 male patients ( ASA I , Mallampati I , limb surgery ) were randomly allocated to four groups ( n=10 each ) . OS : Oral intubation , suxamethonium ( 1.5 mg/kg ) ; OV : Oral intubation , vecuronium ( 0.1 mg/kg ) ; NS : Nasal intubation , suxamethonium ( 1.5 mg/kg ) ; and NV : Nasal intubation , vecuronium ( 0.1 mg/kg ) . Intubation was performed 100 s after injection of the relaxant . Pre- and postoperatively ( every 24 h over 3 days , in case of positive findings longer ) recorded were : active movements of the mandible ( maximal mouth opening/max . laterotrusion ) ; dysfunction of the TMJ ; and pain sensation in the TMJ ( Helkimo rating ) . MOTs and EITs were recorded and analysed with the system described and typical EIT patterns were identified : bland , clinically uneventful intubations ( n=7), massive distraction and laterotrusion of the EIT compared to the MOT ( n=24), and blocked or limited TMJ movements resulting in intubation problems ( n=1). With the method presented , TMJ movements could be visualised during endotracheal intubation for the first time . It can be used to assess techniques , routes , and instruments for intubation as well as to evaluate potential traumatising movements during endotracheal intubation . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Laryngoscopy causes temporary postoperative dysfunction of the temporomandibular joint ( TMJ ) : during iatrogenic TMJ manipulation in anaesthetised patients , the TMJs have lost the protection afforded by the tone of the surrounding muscles . Thus far , the exact type and extent of TMJ movements have not been known . The purpose of this study was to develop a method to visualise and assess TMJ movements during intubation by means of electronic axiography , a diagnostic monitor of TMJ movements used in dentistry : registration of the hinge axis ( HA ) as an equivalent of the condylar paths on extra-oral sagittally mounted , parallel plates . The HA is individually defined in each patient by the pure , rotating TMJ movement during initial mouth opening ( no farward gliding of the condyles , incisor distance up to 10 mm ) . The parallel plates are placed in the TMJ region in the skull-mounted plate bow ; both registration tips ( " drawing " the HA tracings on the electronic plates ) are connected to the mandible by a face bow , paraocclusally fixed to the teeth . The face bow is individually shaped for each patient to allow mask ventilation and free movement of the laryngoscope during intubation . HA tracings are registered and calculated for both sides independently every 24 ms with the SAM/Klett system and presented on sagittal and frontal projections . In the operating theatre , the active mouth-opening traces ( MOT ) are registered first and the passive endotracheal intubation traces ( EIT ) after induction of anaesthesia ( same head position ) . With informed consent and approval by the ethics committee of the Landesaerztekammer Rheinland-Pfalz , 40 male patients ( ASA I , Mallampati I , limb surgery ) were randomly allocated to four groups ( n=10 each ) . OS : Oral intubation , suxamethonium ( 1.5 mg/kg ) ; OV : Oral intubation , vecuronium ( 0.1 mg/kg ) ; NS : Nasal intubation , suxamethonium ( 1.5 mg/kg ) ; and NV : Nasal intubation , vecuronium ( 0.1 mg/kg ) . Intubation was performed 100 s after injection of the relaxant . Pre- and postoperatively ( every 24 h over 3 days , in case of positive findings longer ) recorded were : active movements of the mandible ( maximal mouth opening/max . laterotrusion ) ; dysfunction of the TMJ ; and pain sensation in the TMJ ( Helkimo rating ) . MOTs and EITs were recorded and analysed with the system described and typical EIT patterns were identified : bland , clinically uneventful intubations ( n=7), massive distraction and laterotrusion of the EIT compared to the MOT ( n=24), and blocked or limited TMJ movements resulting in intubation problems ( n=1). With the method presented , TMJ movements could be visualised during endotracheal intubation for the first time . It can be used to assess techniques , routes , and instruments for intubation as well as to evaluate potential traumatising movements during endotracheal intubation .

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[ "umlsterm" ]

Laryngoscopy is an umlsterm, postoperative is an umlsterm, dysfunction is an umlsterm, temporomandibular joint is an umlsterm, TMJ is an umlsterm, TMJ is an umlsterm, patients is an umlsterm, muscles is an umlsterm, exact is an umlsterm, TMJ is an umlsterm, movements is an umlsterm, method is an umlsterm, TMJ is an umlsterm, movements is an umlsterm, intubation is an umlsterm, electronic is an umlsterm, axiography is an umlsterm, diagnostic is an umlsterm, monitor is an umlsterm, TMJ is an umlsterm, movements is an umlsterm, dentistry is an umlsterm, axis is an umlsterm, plates is an umlsterm, patient is an umlsterm, TMJ is an umlsterm, movement is an umlsterm, mouth is an umlsterm, farward is an umlsterm, incisor is an umlsterm, distance is an umlsterm, plates is an umlsterm, TMJ is an umlsterm, skull - mounted is an umlsterm, plate is an umlsterm, tips is an umlsterm, electronic is an umlsterm, plates is an umlsterm, mandible is an umlsterm, face is an umlsterm, teeth is an umlsterm, face is an umlsterm, patient is an umlsterm, mask is an umlsterm, ventilation is an umlsterm, movement is an umlsterm, laryngoscope is an umlsterm, intubation is an umlsterm, projections is an umlsterm, operating theatre is an umlsterm, endotracheal intubation is an umlsterm, head is an umlsterm, ethics committee is an umlsterm, male is an umlsterm, patients is an umlsterm, ASA is an umlsterm, Mallampati is an umlsterm, limb is an umlsterm, surgery is an umlsterm, intubation is an umlsterm, suxamethonium is an umlsterm, intubation is an umlsterm, vecuronium is an umlsterm, intubation is an umlsterm, suxamethonium is an umlsterm, intubation is an umlsterm, vecuronium is an umlsterm, Intubation is an umlsterm, injection is an umlsterm, findings is an umlsterm, movements is an umlsterm, mandible is an umlsterm, mouth is an umlsterm, dysfunction is an umlsterm, TMJ is an umlsterm, pain is an umlsterm, sensation is an umlsterm, TMJ is an umlsterm, intubations is an umlsterm, TMJ is an umlsterm, movements is an umlsterm, intubation is an umlsterm, method is an umlsterm, TMJ is an umlsterm, movements is an umlsterm, endotracheal intubation is an umlsterm, time is an umlsterm, techniques is an umlsterm, instruments is an umlsterm, intubation is an umlsterm, movements is an umlsterm, endotracheal intubation is an umlsterm

DerAnaesthesist.60450907.eng.abstr_task1

Sentence: Laryngoscopy causes temporary postoperative dysfunction of the temporomandibular joint ( TMJ ) : during iatrogenic TMJ manipulation in anaesthetised patients , the TMJs have lost the protection afforded by the tone of the surrounding muscles . Thus far , the exact type and extent of TMJ movements have not been known . The purpose of this study was to develop a method to visualise and assess TMJ movements during intubation by means of electronic axiography , a diagnostic monitor of TMJ movements used in dentistry : registration of the hinge axis ( HA ) as an equivalent of the condylar paths on extra-oral sagittally mounted , parallel plates . The HA is individually defined in each patient by the pure , rotating TMJ movement during initial mouth opening ( no farward gliding of the condyles , incisor distance up to 10 mm ) . The parallel plates are placed in the TMJ region in the skull-mounted plate bow ; both registration tips ( " drawing " the HA tracings on the electronic plates ) are connected to the mandible by a face bow , paraocclusally fixed to the teeth . The face bow is individually shaped for each patient to allow mask ventilation and free movement of the laryngoscope during intubation . HA tracings are registered and calculated for both sides independently every 24 ms with the SAM/Klett system and presented on sagittal and frontal projections . In the operating theatre , the active mouth-opening traces ( MOT ) are registered first and the passive endotracheal intubation traces ( EIT ) after induction of anaesthesia ( same head position ) . With informed consent and approval by the ethics committee of the Landesaerztekammer Rheinland-Pfalz , 40 male patients ( ASA I , Mallampati I , limb surgery ) were randomly allocated to four groups ( n=10 each ) . OS : Oral intubation , suxamethonium ( 1.5 mg/kg ) ; OV : Oral intubation , vecuronium ( 0.1 mg/kg ) ; NS : Nasal intubation , suxamethonium ( 1.5 mg/kg ) ; and NV : Nasal intubation , vecuronium ( 0.1 mg/kg ) . Intubation was performed 100 s after injection of the relaxant . Pre- and postoperatively ( every 24 h over 3 days , in case of positive findings longer ) recorded were : active movements of the mandible ( maximal mouth opening/max . laterotrusion ) ; dysfunction of the TMJ ; and pain sensation in the TMJ ( Helkimo rating ) . MOTs and EITs were recorded and analysed with the system described and typical EIT patterns were identified : bland , clinically uneventful intubations ( n=7), massive distraction and laterotrusion of the EIT compared to the MOT ( n=24), and blocked or limited TMJ movements resulting in intubation problems ( n=1). With the method presented , TMJ movements could be visualised during endotracheal intubation for the first time . It can be used to assess techniques , routes , and instruments for intubation as well as to evaluate potential traumatising movements during endotracheal intubation . Instructions: please typing these entity words according to sentence: Laryngoscopy, postoperative, dysfunction, temporomandibular joint, TMJ, TMJ, patients, muscles, exact, TMJ, movements, method, TMJ, movements, intubation, electronic, axiography, diagnostic, monitor, TMJ, movements, dentistry, axis, plates, patient, TMJ, movement, mouth, farward, incisor, distance, plates, TMJ, skull - mounted, plate, tips, electronic, plates, mandible, face, teeth, face, patient, mask, ventilation, movement, laryngoscope, intubation, projections, operating theatre, endotracheal intubation, head, ethics committee, male, patients, ASA, Mallampati, limb, surgery, intubation, suxamethonium, intubation, vecuronium, intubation, suxamethonium, intubation, vecuronium, Intubation, injection, findings, movements, mandible, mouth, dysfunction, TMJ, pain, sensation, TMJ, intubations, TMJ, movements, intubation, method, TMJ, movements, endotracheal intubation, time, techniques, instruments, intubation, movements, endotracheal intubation Options: umlsterm

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Laryngoscopy causes temporary postoperative dysfunction of the temporomandibular joint ( TMJ ) : during iatrogenic TMJ manipulation in anaesthetised patients , the TMJs have lost the protection afforded by the tone of the surrounding muscles . Thus far , the exact type and extent of TMJ movements have not been known . The purpose of this study was to develop a method to visualise and assess TMJ movements during intubation by means of electronic axiography , a diagnostic monitor of TMJ movements used in dentistry : registration of the hinge axis ( HA ) as an equivalent of the condylar paths on extra-oral sagittally mounted , parallel plates . The HA is individually defined in each patient by the pure , rotating TMJ movement during initial mouth opening ( no farward gliding of the condyles , incisor distance up to 10 mm ) . The parallel plates are placed in the TMJ region in the skull-mounted plate bow ; both registration tips ( " drawing " the HA tracings on the electronic plates ) are connected to the mandible by a face bow , paraocclusally fixed to the teeth . The face bow is individually shaped for each patient to allow mask ventilation and free movement of the laryngoscope during intubation . HA tracings are registered and calculated for both sides independently every 24 ms with the SAM/Klett system and presented on sagittal and frontal projections . In the operating theatre , the active mouth-opening traces ( MOT ) are registered first and the passive endotracheal intubation traces ( EIT ) after induction of anaesthesia ( same head position ) . With informed consent and approval by the ethics committee of the Landesaerztekammer Rheinland-Pfalz , 40 male patients ( ASA I , Mallampati I , limb surgery ) were randomly allocated to four groups ( n=10 each ) . OS : Oral intubation , suxamethonium ( 1.5 mg/kg ) ; OV : Oral intubation , vecuronium ( 0.1 mg/kg ) ; NS : Nasal intubation , suxamethonium ( 1.5 mg/kg ) ; and NV : Nasal intubation , vecuronium ( 0.1 mg/kg ) . Intubation was performed 100 s after injection of the relaxant . Pre- and postoperatively ( every 24 h over 3 days , in case of positive findings longer ) recorded were : active movements of the mandible ( maximal mouth opening/max . laterotrusion ) ; dysfunction of the TMJ ; and pain sensation in the TMJ ( Helkimo rating ) . MOTs and EITs were recorded and analysed with the system described and typical EIT patterns were identified : bland , clinically uneventful intubations ( n=7), massive distraction and laterotrusion of the EIT compared to the MOT ( n=24), and blocked or limited TMJ movements resulting in intubation problems ( n=1). With the method presented , TMJ movements could be visualised during endotracheal intubation for the first time . It can be used to assess techniques , routes , and instruments for intubation as well as to evaluate potential traumatising movements during endotracheal intubation .

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[ "umlsterm" ]

Laryngoscopy, postoperative, dysfunction, temporomandibular joint, TMJ, TMJ, patients, muscles, exact, TMJ, movements, method, TMJ, movements, intubation, electronic, axiography, diagnostic, monitor, TMJ, movements, dentistry, axis, plates, patient, TMJ, movement, mouth, farward, incisor, distance, plates, TMJ, skull - mounted, plate, tips, electronic, plates, mandible, face, teeth, face, patient, mask, ventilation, movement, laryngoscope, intubation, projections, operating theatre, endotracheal intubation, head, ethics committee, male, patients, ASA, Mallampati, limb, surgery, intubation, suxamethonium, intubation, vecuronium, intubation, suxamethonium, intubation, vecuronium, Intubation, injection, findings, movements, mandible, mouth, dysfunction, TMJ, pain, sensation, TMJ, intubations, TMJ, movements, intubation, method, TMJ, movements, endotracheal intubation, time, techniques, instruments, intubation, movements, endotracheal intubation

DerAnaesthesist.60450907.eng.abstr_task2

Sentence: Laryngoscopy causes temporary postoperative dysfunction of the temporomandibular joint ( TMJ ) : during iatrogenic TMJ manipulation in anaesthetised patients , the TMJs have lost the protection afforded by the tone of the surrounding muscles . Thus far , the exact type and extent of TMJ movements have not been known . The purpose of this study was to develop a method to visualise and assess TMJ movements during intubation by means of electronic axiography , a diagnostic monitor of TMJ movements used in dentistry : registration of the hinge axis ( HA ) as an equivalent of the condylar paths on extra-oral sagittally mounted , parallel plates . The HA is individually defined in each patient by the pure , rotating TMJ movement during initial mouth opening ( no farward gliding of the condyles , incisor distance up to 10 mm ) . The parallel plates are placed in the TMJ region in the skull-mounted plate bow ; both registration tips ( " drawing " the HA tracings on the electronic plates ) are connected to the mandible by a face bow , paraocclusally fixed to the teeth . The face bow is individually shaped for each patient to allow mask ventilation and free movement of the laryngoscope during intubation . HA tracings are registered and calculated for both sides independently every 24 ms with the SAM/Klett system and presented on sagittal and frontal projections . In the operating theatre , the active mouth-opening traces ( MOT ) are registered first and the passive endotracheal intubation traces ( EIT ) after induction of anaesthesia ( same head position ) . With informed consent and approval by the ethics committee of the Landesaerztekammer Rheinland-Pfalz , 40 male patients ( ASA I , Mallampati I , limb surgery ) were randomly allocated to four groups ( n=10 each ) . OS : Oral intubation , suxamethonium ( 1.5 mg/kg ) ; OV : Oral intubation , vecuronium ( 0.1 mg/kg ) ; NS : Nasal intubation , suxamethonium ( 1.5 mg/kg ) ; and NV : Nasal intubation , vecuronium ( 0.1 mg/kg ) . Intubation was performed 100 s after injection of the relaxant . Pre- and postoperatively ( every 24 h over 3 days , in case of positive findings longer ) recorded were : active movements of the mandible ( maximal mouth opening/max . laterotrusion ) ; dysfunction of the TMJ ; and pain sensation in the TMJ ( Helkimo rating ) . MOTs and EITs were recorded and analysed with the system described and typical EIT patterns were identified : bland , clinically uneventful intubations ( n=7), massive distraction and laterotrusion of the EIT compared to the MOT ( n=24), and blocked or limited TMJ movements resulting in intubation problems ( n=1). With the method presented , TMJ movements could be visualised during endotracheal intubation for the first time . It can be used to assess techniques , routes , and instruments for intubation as well as to evaluate potential traumatising movements during endotracheal intubation . Instructions: please extract entity words from the input sentence

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Laryngoscopy causes temporary postoperative dysfunction of the temporomandibular joint ( TMJ ) : during iatrogenic TMJ manipulation in anaesthetised patients , the TMJs have lost the protection afforded by the tone of the surrounding muscles . Thus far , the exact type and extent of TMJ movements have not been known . The purpose of this study was to develop a method to visualise and assess TMJ movements during intubation by means of electronic axiography , a diagnostic monitor of TMJ movements used in dentistry : registration of the hinge axis ( HA ) as an equivalent of the condylar paths on extra-oral sagittally mounted , parallel plates . The HA is individually defined in each patient by the pure , rotating TMJ movement during initial mouth opening ( no farward gliding of the condyles , incisor distance up to 10 mm ) . The parallel plates are placed in the TMJ region in the skull-mounted plate bow ; both registration tips ( " drawing " the HA tracings on the electronic plates ) are connected to the mandible by a face bow , paraocclusally fixed to the teeth . The face bow is individually shaped for each patient to allow mask ventilation and free movement of the laryngoscope during intubation . HA tracings are registered and calculated for both sides independently every 24 ms with the SAM/Klett system and presented on sagittal and frontal projections . In the operating theatre , the active mouth-opening traces ( MOT ) are registered first and the passive endotracheal intubation traces ( EIT ) after induction of anaesthesia ( same head position ) . With informed consent and approval by the ethics committee of the Landesaerztekammer Rheinland-Pfalz , 40 male patients ( ASA I , Mallampati I , limb surgery ) were randomly allocated to four groups ( n=10 each ) . OS : Oral intubation , suxamethonium ( 1.5 mg/kg ) ; OV : Oral intubation , vecuronium ( 0.1 mg/kg ) ; NS : Nasal intubation , suxamethonium ( 1.5 mg/kg ) ; and NV : Nasal intubation , vecuronium ( 0.1 mg/kg ) . Intubation was performed 100 s after injection of the relaxant . Pre- and postoperatively ( every 24 h over 3 days , in case of positive findings longer ) recorded were : active movements of the mandible ( maximal mouth opening/max . laterotrusion ) ; dysfunction of the TMJ ; and pain sensation in the TMJ ( Helkimo rating ) . MOTs and EITs were recorded and analysed with the system described and typical EIT patterns were identified : bland , clinically uneventful intubations ( n=7), massive distraction and laterotrusion of the EIT compared to the MOT ( n=24), and blocked or limited TMJ movements resulting in intubation problems ( n=1). With the method presented , TMJ movements could be visualised during endotracheal intubation for the first time . It can be used to assess techniques , routes , and instruments for intubation as well as to evaluate potential traumatising movements during endotracheal intubation .

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[ "umlsterm" ]

Prozessanalyse is an umlsterm, Verzoegerungen is an umlsterm, Patienten is an umlsterm

Notfall+Rettungsmedizin.90020274.ger.abstr_task0

Sentence: Am Beispiel eines innerstaedtischen Notarztsystems wurde eine prospektive Prozessanalyse auf der Basis der Definitionen des Utstein-Style " " durchgefuehrt . Untersucht wurden Verzoegerungen und Unterbrechungen im organisatorischen , medizinischen und medizinisch-technischen Bereich bei ausserklinischen Wiederbelebungsmassnahmen anhand eines Kollektiv von n=71 reanimationspflichtigen Patienten . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

Am Beispiel eines innerstaedtischen Notarztsystems wurde eine prospektive Prozessanalyse auf der Basis der Definitionen des Utstein-Style " " durchgefuehrt . Untersucht wurden Verzoegerungen und Unterbrechungen im organisatorischen , medizinischen und medizinisch-technischen Bereich bei ausserklinischen Wiederbelebungsmassnahmen anhand eines Kollektiv von n=71 reanimationspflichtigen Patienten .

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[ "umlsterm" ]

Prozessanalyse is an umlsterm, Verzoegerungen is an umlsterm, Patienten is an umlsterm

Notfall+Rettungsmedizin.90020274.ger.abstr_task1

Sentence: Am Beispiel eines innerstaedtischen Notarztsystems wurde eine prospektive Prozessanalyse auf der Basis der Definitionen des Utstein-Style " " durchgefuehrt . Untersucht wurden Verzoegerungen und Unterbrechungen im organisatorischen , medizinischen und medizinisch-technischen Bereich bei ausserklinischen Wiederbelebungsmassnahmen anhand eines Kollektiv von n=71 reanimationspflichtigen Patienten . Instructions: please typing these entity words according to sentence: Prozessanalyse, Verzoegerungen, Patienten Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

Am Beispiel eines innerstaedtischen Notarztsystems wurde eine prospektive Prozessanalyse auf der Basis der Definitionen des Utstein-Style " " durchgefuehrt . Untersucht wurden Verzoegerungen und Unterbrechungen im organisatorischen , medizinischen und medizinisch-technischen Bereich bei ausserklinischen Wiederbelebungsmassnahmen anhand eines Kollektiv von n=71 reanimationspflichtigen Patienten .

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[ "umlsterm" ]

Prozessanalyse, Verzoegerungen, Patienten

Notfall+Rettungsmedizin.90020274.ger.abstr_task2

Sentence: Am Beispiel eines innerstaedtischen Notarztsystems wurde eine prospektive Prozessanalyse auf der Basis der Definitionen des Utstein-Style " " durchgefuehrt . Untersucht wurden Verzoegerungen und Unterbrechungen im organisatorischen , medizinischen und medizinisch-technischen Bereich bei ausserklinischen Wiederbelebungsmassnahmen anhand eines Kollektiv von n=71 reanimationspflichtigen Patienten . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

Am Beispiel eines innerstaedtischen Notarztsystems wurde eine prospektive Prozessanalyse auf der Basis der Definitionen des Utstein-Style " " durchgefuehrt . Untersucht wurden Verzoegerungen und Unterbrechungen im organisatorischen , medizinischen und medizinisch-technischen Bereich bei ausserklinischen Wiederbelebungsmassnahmen anhand eines Kollektiv von n=71 reanimationspflichtigen Patienten .

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[ "umlsterm" ]

beta 3-adrenoceptor is a GENE-Y, BRL35135 is a CHEMICAL, beta 3-adrenoceptor is a GENE-Y, BRL35135 is a CHEMICAL, beta 3-receptors is a GENE-Y, BRL35135 is a CHEMICAL, BRL is a CHEMICAL, beta 2-adrenoceptor is a GENE-Y, salbutamol is a CHEMICAL, SAL is a CHEMICAL, bisoprolol is a CHEMICAL, beta 1-adrenoceptor is a GENE-Y, nadolol is a CHEMICAL, beta 1- and beta 2- but not beta 3-receptors is a GENE-N, BRL is a CHEMICAL, SAL is a CHEMICAL, beta 2-adrenoceptor is a GENE-Y, BRL is a CHEMICAL, SAL is a CHEMICAL, BRL is a CHEMICAL, SAL is a CHEMICAL, beta 1-adrenoceptor is a GENE-Y, SAL is a CHEMICAL, BRL is a CHEMICAL, BRL is a CHEMICAL

28688_task0

Sentence: Cardiac effects of the beta 3-adrenoceptor agonist BRL35135 in man. The aim of the present study was to evaluate the cardiac effects of the beta 3-adrenoceptor agonist BRL35135, and determine whether beta 3-receptors are involved in mediating chronotropic or inotropic responses in man. Eight normal males received single oral doses of BRL35135 8 mg (BRL) or the selective beta 2-adrenoceptor agonist salbutamol 8 mg (SAL), after pretreatment with either placebo (PL), bisoprolol 5 mg (B5) as a selective beta 1-adrenoceptor antagonist, or nadolol 20 mg (N20) to block beta 1- and beta 2- but not beta 3-receptors. Both BRL and SAL produced a significant increase in postural finger tremor in keeping with beta 2-adrenoceptor stimulation, and this response was totally abolished by pretreatment with N20. Significant increases in systolic blood pressure and Doppler stroke distance occurred with BRL and SAL which were unaffected by pretreatment with B5 and completely blocked by N20, in keeping with beta 2-mediated effects. BRL and SAL produced significant chronotropic and minute distance responses which were unaffected by beta 1-adrenoceptor blockade. However, whereas N20 blocked these responses to SAL, a small but significant response occurred with BRL in comparison with placebo despite complete blockade of co-existing beta 2-mediated effects. Compared with PL, the mean responses to N20/BRL, and the 95% confidence interval for the differences between the means were 7.4 beats min-1 [3.2 to 11.6] (P = 0.002) for heart rate, and 208.8 cm [38.3 to 379.3] (P = 0.02) for minute distance responses.(ABSTRACT TRUNCATED AT 250 WORDS) Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N, GENE-Y, CHEMICAL

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Cardiac effects of the beta 3-adrenoceptor agonist BRL35135 in man. The aim of the present study was to evaluate the cardiac effects of the beta 3-adrenoceptor agonist BRL35135, and determine whether beta 3-receptors are involved in mediating chronotropic or inotropic responses in man. Eight normal males received single oral doses of BRL35135 8 mg (BRL) or the selective beta 2-adrenoceptor agonist salbutamol 8 mg (SAL), after pretreatment with either placebo (PL), bisoprolol 5 mg (B5) as a selective beta 1-adrenoceptor antagonist, or nadolol 20 mg (N20) to block beta 1- and beta 2- but not beta 3-receptors. Both BRL and SAL produced a significant increase in postural finger tremor in keeping with beta 2-adrenoceptor stimulation, and this response was totally abolished by pretreatment with N20. Significant increases in systolic blood pressure and Doppler stroke distance occurred with BRL and SAL which were unaffected by pretreatment with B5 and completely blocked by N20, in keeping with beta 2-mediated effects. BRL and SAL produced significant chronotropic and minute distance responses which were unaffected by beta 1-adrenoceptor blockade. However, whereas N20 blocked these responses to SAL, a small but significant response occurred with BRL in comparison with placebo despite complete blockade of co-existing beta 2-mediated effects. Compared with PL, the mean responses to N20/BRL, and the 95% confidence interval for the differences between the means were 7.4 beats min-1 [3.2 to 11.6] (P = 0.002) for heart rate, and 208.8 cm [38.3 to 379.3] (P = 0.02) for minute distance responses.(ABSTRACT TRUNCATED AT 250 WORDS)

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[ "GENE-N", "GENE-Y", "CHEMICAL" ]

beta 3-adrenoceptor is a GENE-Y, BRL35135 is a CHEMICAL, beta 3-adrenoceptor is a GENE-Y, BRL35135 is a CHEMICAL, beta 3-receptors is a GENE-Y, BRL35135 is a CHEMICAL, BRL is a CHEMICAL, beta 2-adrenoceptor is a GENE-Y, salbutamol is a CHEMICAL, SAL is a CHEMICAL, bisoprolol is a CHEMICAL, beta 1-adrenoceptor is a GENE-Y, nadolol is a CHEMICAL, beta 1- and beta 2- but not beta 3-receptors is a GENE-N, BRL is a CHEMICAL, SAL is a CHEMICAL, beta 2-adrenoceptor is a GENE-Y, BRL is a CHEMICAL, SAL is a CHEMICAL, BRL is a CHEMICAL, SAL is a CHEMICAL, beta 1-adrenoceptor is a GENE-Y, SAL is a CHEMICAL, BRL is a CHEMICAL, BRL is a CHEMICAL

28688_task1

Sentence: Cardiac effects of the beta 3-adrenoceptor agonist BRL35135 in man. The aim of the present study was to evaluate the cardiac effects of the beta 3-adrenoceptor agonist BRL35135, and determine whether beta 3-receptors are involved in mediating chronotropic or inotropic responses in man. Eight normal males received single oral doses of BRL35135 8 mg (BRL) or the selective beta 2-adrenoceptor agonist salbutamol 8 mg (SAL), after pretreatment with either placebo (PL), bisoprolol 5 mg (B5) as a selective beta 1-adrenoceptor antagonist, or nadolol 20 mg (N20) to block beta 1- and beta 2- but not beta 3-receptors. Both BRL and SAL produced a significant increase in postural finger tremor in keeping with beta 2-adrenoceptor stimulation, and this response was totally abolished by pretreatment with N20. Significant increases in systolic blood pressure and Doppler stroke distance occurred with BRL and SAL which were unaffected by pretreatment with B5 and completely blocked by N20, in keeping with beta 2-mediated effects. BRL and SAL produced significant chronotropic and minute distance responses which were unaffected by beta 1-adrenoceptor blockade. However, whereas N20 blocked these responses to SAL, a small but significant response occurred with BRL in comparison with placebo despite complete blockade of co-existing beta 2-mediated effects. Compared with PL, the mean responses to N20/BRL, and the 95% confidence interval for the differences between the means were 7.4 beats min-1 [3.2 to 11.6] (P = 0.002) for heart rate, and 208.8 cm [38.3 to 379.3] (P = 0.02) for minute distance responses.(ABSTRACT TRUNCATED AT 250 WORDS) Instructions: please typing these entity words according to sentence: beta 3-adrenoceptor, BRL35135, beta 3-adrenoceptor, BRL35135, beta 3-receptors, BRL35135, BRL, beta 2-adrenoceptor, salbutamol, SAL, bisoprolol, beta 1-adrenoceptor, nadolol, beta 1- and beta 2- but not beta 3-receptors, BRL, SAL, beta 2-adrenoceptor, BRL, SAL, BRL, SAL, beta 1-adrenoceptor, SAL, BRL, BRL Options: GENE-N, GENE-Y, CHEMICAL

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Cardiac effects of the beta 3-adrenoceptor agonist BRL35135 in man. The aim of the present study was to evaluate the cardiac effects of the beta 3-adrenoceptor agonist BRL35135, and determine whether beta 3-receptors are involved in mediating chronotropic or inotropic responses in man. Eight normal males received single oral doses of BRL35135 8 mg (BRL) or the selective beta 2-adrenoceptor agonist salbutamol 8 mg (SAL), after pretreatment with either placebo (PL), bisoprolol 5 mg (B5) as a selective beta 1-adrenoceptor antagonist, or nadolol 20 mg (N20) to block beta 1- and beta 2- but not beta 3-receptors. Both BRL and SAL produced a significant increase in postural finger tremor in keeping with beta 2-adrenoceptor stimulation, and this response was totally abolished by pretreatment with N20. Significant increases in systolic blood pressure and Doppler stroke distance occurred with BRL and SAL which were unaffected by pretreatment with B5 and completely blocked by N20, in keeping with beta 2-mediated effects. BRL and SAL produced significant chronotropic and minute distance responses which were unaffected by beta 1-adrenoceptor blockade. However, whereas N20 blocked these responses to SAL, a small but significant response occurred with BRL in comparison with placebo despite complete blockade of co-existing beta 2-mediated effects. Compared with PL, the mean responses to N20/BRL, and the 95% confidence interval for the differences between the means were 7.4 beats min-1 [3.2 to 11.6] (P = 0.002) for heart rate, and 208.8 cm [38.3 to 379.3] (P = 0.02) for minute distance responses.(ABSTRACT TRUNCATED AT 250 WORDS)

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[ "GENE-N", "GENE-Y", "CHEMICAL" ]

beta 3-adrenoceptor, BRL35135, beta 3-adrenoceptor, BRL35135, beta 3-receptors, BRL35135, BRL, beta 2-adrenoceptor, salbutamol, SAL, bisoprolol, beta 1-adrenoceptor, nadolol, beta 1- and beta 2- but not beta 3-receptors, BRL, SAL, beta 2-adrenoceptor, BRL, SAL, BRL, SAL, beta 1-adrenoceptor, SAL, BRL, BRL

28688_task2

Sentence: Cardiac effects of the beta 3-adrenoceptor agonist BRL35135 in man. The aim of the present study was to evaluate the cardiac effects of the beta 3-adrenoceptor agonist BRL35135, and determine whether beta 3-receptors are involved in mediating chronotropic or inotropic responses in man. Eight normal males received single oral doses of BRL35135 8 mg (BRL) or the selective beta 2-adrenoceptor agonist salbutamol 8 mg (SAL), after pretreatment with either placebo (PL), bisoprolol 5 mg (B5) as a selective beta 1-adrenoceptor antagonist, or nadolol 20 mg (N20) to block beta 1- and beta 2- but not beta 3-receptors. Both BRL and SAL produced a significant increase in postural finger tremor in keeping with beta 2-adrenoceptor stimulation, and this response was totally abolished by pretreatment with N20. Significant increases in systolic blood pressure and Doppler stroke distance occurred with BRL and SAL which were unaffected by pretreatment with B5 and completely blocked by N20, in keeping with beta 2-mediated effects. BRL and SAL produced significant chronotropic and minute distance responses which were unaffected by beta 1-adrenoceptor blockade. However, whereas N20 blocked these responses to SAL, a small but significant response occurred with BRL in comparison with placebo despite complete blockade of co-existing beta 2-mediated effects. Compared with PL, the mean responses to N20/BRL, and the 95% confidence interval for the differences between the means were 7.4 beats min-1 [3.2 to 11.6] (P = 0.002) for heart rate, and 208.8 cm [38.3 to 379.3] (P = 0.02) for minute distance responses.(ABSTRACT TRUNCATED AT 250 WORDS) Instructions: please extract entity words from the input sentence

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Cardiac effects of the beta 3-adrenoceptor agonist BRL35135 in man. The aim of the present study was to evaluate the cardiac effects of the beta 3-adrenoceptor agonist BRL35135, and determine whether beta 3-receptors are involved in mediating chronotropic or inotropic responses in man. Eight normal males received single oral doses of BRL35135 8 mg (BRL) or the selective beta 2-adrenoceptor agonist salbutamol 8 mg (SAL), after pretreatment with either placebo (PL), bisoprolol 5 mg (B5) as a selective beta 1-adrenoceptor antagonist, or nadolol 20 mg (N20) to block beta 1- and beta 2- but not beta 3-receptors. Both BRL and SAL produced a significant increase in postural finger tremor in keeping with beta 2-adrenoceptor stimulation, and this response was totally abolished by pretreatment with N20. Significant increases in systolic blood pressure and Doppler stroke distance occurred with BRL and SAL which were unaffected by pretreatment with B5 and completely blocked by N20, in keeping with beta 2-mediated effects. BRL and SAL produced significant chronotropic and minute distance responses which were unaffected by beta 1-adrenoceptor blockade. However, whereas N20 blocked these responses to SAL, a small but significant response occurred with BRL in comparison with placebo despite complete blockade of co-existing beta 2-mediated effects. Compared with PL, the mean responses to N20/BRL, and the 95% confidence interval for the differences between the means were 7.4 beats min-1 [3.2 to 11.6] (P = 0.002) for heart rate, and 208.8 cm [38.3 to 379.3] (P = 0.02) for minute distance responses.(ABSTRACT TRUNCATED AT 250 WORDS)

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[ "GENE-N", "GENE-Y", "CHEMICAL" ]

paraquat is a CHEMICAL

23523781_task0

Sentence: Pharmacokinetic, neurochemical, stereological and neuropathological studies on the potential effects of paraquat in the substantia nigra pars compacta and striatum of male C57BL/6J mice. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Pharmacokinetic, neurochemical, stereological and neuropathological studies on the potential effects of paraquat in the substantia nigra pars compacta and striatum of male C57BL/6J mice.

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[ "CHEMICAL", "GENE-Y" ]

paraquat is a CHEMICAL

23523781_task1

Sentence: Pharmacokinetic, neurochemical, stereological and neuropathological studies on the potential effects of paraquat in the substantia nigra pars compacta and striatum of male C57BL/6J mice. Instructions: please typing these entity words according to sentence: paraquat Options: CHEMICAL

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Pharmacokinetic, neurochemical, stereological and neuropathological studies on the potential effects of paraquat in the substantia nigra pars compacta and striatum of male C57BL/6J mice.

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[ "CHEMICAL", "GENE-Y" ]

paraquat

23523781_task2

Sentence: Pharmacokinetic, neurochemical, stereological and neuropathological studies on the potential effects of paraquat in the substantia nigra pars compacta and striatum of male C57BL/6J mice. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Pharmacokinetic, neurochemical, stereological and neuropathological studies on the potential effects of paraquat in the substantia nigra pars compacta and striatum of male C57BL/6J mice.

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[ "CHEMICAL", "GENE-Y" ]

Knochentumoren is an umlsterm, Chondrom is an umlsterm, Chondrosarkom is an umlsterm, Beurteilung is an umlsterm, mehrkernige Riesenzellen is an umlsterm, Erkennung is an umlsterm, Zysten is an umlsterm, Zyste is an umlsterm, Kallus is an umlsterm, Osteosarkom is an umlsterm, Chondroblastome is an umlsterm, Riesenzelltumoren is an umlsterm, Osteosarkom is an umlsterm, Knochentumordiagnostik is an umlsterm, Verhaltens is an umlsterm

DerPathologe.60170001.ger.abstr_task0

Sentence: Die diagnostische Konsiliartaetigkeit bei Knochentumoren zeigt , dass ausser bei besonders selten vorkommenden Laesionen Schwierigkeiten in der Einstufung Chondrom - Chondrosarkom , in der Beurteilung von reichlich mehrkernige Riesenzellen enthaltenden Prozessen und in der Erkennung von Laesionen mit sekundaeren Zysten , die eine juvenile oder aneurysmatische Zyste simulieren , bestehen , sowie manchmal in der Unterscheidung Kallus vs. Osteosarkom . De-facto-Fehlinterpretationen betreffen ossifizierende Pseudotumore , die als Osteosarkome , metaphysaere fibroese Defekte und Chondroblastome , die als Riesenzelltumoren eingeschaetzt werden , letztere auch als Osteosarkom . Die Knochentumordiagnostik muss unter Beruecksichtigung der klinischen Daten , insbesondere des Alters und v. a. unter Einbeziehung des Verhaltens der Laesionen in den bildgebenden Verfahren erfolgen . Der Pathologe muss ueber Grundkenntnisse in deren Deutung verfuegen . Die angegebenen typischen Fehlinterpretationen sind so ohne Laboraufwand mit dem gewoehnlichen HE-Schnitt zu vermeiden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Die diagnostische Konsiliartaetigkeit bei Knochentumoren zeigt , dass ausser bei besonders selten vorkommenden Laesionen Schwierigkeiten in der Einstufung Chondrom - Chondrosarkom , in der Beurteilung von reichlich mehrkernige Riesenzellen enthaltenden Prozessen und in der Erkennung von Laesionen mit sekundaeren Zysten , die eine juvenile oder aneurysmatische Zyste simulieren , bestehen , sowie manchmal in der Unterscheidung Kallus vs. Osteosarkom . De-facto-Fehlinterpretationen betreffen ossifizierende Pseudotumore , die als Osteosarkome , metaphysaere fibroese Defekte und Chondroblastome , die als Riesenzelltumoren eingeschaetzt werden , letztere auch als Osteosarkom . Die Knochentumordiagnostik muss unter Beruecksichtigung der klinischen Daten , insbesondere des Alters und v. a. unter Einbeziehung des Verhaltens der Laesionen in den bildgebenden Verfahren erfolgen . Der Pathologe muss ueber Grundkenntnisse in deren Deutung verfuegen . Die angegebenen typischen Fehlinterpretationen sind so ohne Laboraufwand mit dem gewoehnlichen HE-Schnitt zu vermeiden .

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[ "umlsterm" ]

Knochentumoren is an umlsterm, Chondrom is an umlsterm, Chondrosarkom is an umlsterm, Beurteilung is an umlsterm, mehrkernige Riesenzellen is an umlsterm, Erkennung is an umlsterm, Zysten is an umlsterm, Zyste is an umlsterm, Kallus is an umlsterm, Osteosarkom is an umlsterm, Chondroblastome is an umlsterm, Riesenzelltumoren is an umlsterm, Osteosarkom is an umlsterm, Knochentumordiagnostik is an umlsterm, Verhaltens is an umlsterm

DerPathologe.60170001.ger.abstr_task1

Sentence: Die diagnostische Konsiliartaetigkeit bei Knochentumoren zeigt , dass ausser bei besonders selten vorkommenden Laesionen Schwierigkeiten in der Einstufung Chondrom - Chondrosarkom , in der Beurteilung von reichlich mehrkernige Riesenzellen enthaltenden Prozessen und in der Erkennung von Laesionen mit sekundaeren Zysten , die eine juvenile oder aneurysmatische Zyste simulieren , bestehen , sowie manchmal in der Unterscheidung Kallus vs. Osteosarkom . De-facto-Fehlinterpretationen betreffen ossifizierende Pseudotumore , die als Osteosarkome , metaphysaere fibroese Defekte und Chondroblastome , die als Riesenzelltumoren eingeschaetzt werden , letztere auch als Osteosarkom . Die Knochentumordiagnostik muss unter Beruecksichtigung der klinischen Daten , insbesondere des Alters und v. a. unter Einbeziehung des Verhaltens der Laesionen in den bildgebenden Verfahren erfolgen . Der Pathologe muss ueber Grundkenntnisse in deren Deutung verfuegen . Die angegebenen typischen Fehlinterpretationen sind so ohne Laboraufwand mit dem gewoehnlichen HE-Schnitt zu vermeiden . Instructions: please typing these entity words according to sentence: Knochentumoren, Chondrom, Chondrosarkom, Beurteilung, mehrkernige Riesenzellen, Erkennung, Zysten, Zyste, Kallus, Osteosarkom, Chondroblastome, Riesenzelltumoren, Osteosarkom, Knochentumordiagnostik, Verhaltens Options: umlsterm

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Die diagnostische Konsiliartaetigkeit bei Knochentumoren zeigt , dass ausser bei besonders selten vorkommenden Laesionen Schwierigkeiten in der Einstufung Chondrom - Chondrosarkom , in der Beurteilung von reichlich mehrkernige Riesenzellen enthaltenden Prozessen und in der Erkennung von Laesionen mit sekundaeren Zysten , die eine juvenile oder aneurysmatische Zyste simulieren , bestehen , sowie manchmal in der Unterscheidung Kallus vs. Osteosarkom . De-facto-Fehlinterpretationen betreffen ossifizierende Pseudotumore , die als Osteosarkome , metaphysaere fibroese Defekte und Chondroblastome , die als Riesenzelltumoren eingeschaetzt werden , letztere auch als Osteosarkom . Die Knochentumordiagnostik muss unter Beruecksichtigung der klinischen Daten , insbesondere des Alters und v. a. unter Einbeziehung des Verhaltens der Laesionen in den bildgebenden Verfahren erfolgen . Der Pathologe muss ueber Grundkenntnisse in deren Deutung verfuegen . Die angegebenen typischen Fehlinterpretationen sind so ohne Laboraufwand mit dem gewoehnlichen HE-Schnitt zu vermeiden .

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[ "umlsterm" ]

Knochentumoren, Chondrom, Chondrosarkom, Beurteilung, mehrkernige Riesenzellen, Erkennung, Zysten, Zyste, Kallus, Osteosarkom, Chondroblastome, Riesenzelltumoren, Osteosarkom, Knochentumordiagnostik, Verhaltens

DerPathologe.60170001.ger.abstr_task2

Sentence: Die diagnostische Konsiliartaetigkeit bei Knochentumoren zeigt , dass ausser bei besonders selten vorkommenden Laesionen Schwierigkeiten in der Einstufung Chondrom - Chondrosarkom , in der Beurteilung von reichlich mehrkernige Riesenzellen enthaltenden Prozessen und in der Erkennung von Laesionen mit sekundaeren Zysten , die eine juvenile oder aneurysmatische Zyste simulieren , bestehen , sowie manchmal in der Unterscheidung Kallus vs. Osteosarkom . De-facto-Fehlinterpretationen betreffen ossifizierende Pseudotumore , die als Osteosarkome , metaphysaere fibroese Defekte und Chondroblastome , die als Riesenzelltumoren eingeschaetzt werden , letztere auch als Osteosarkom . Die Knochentumordiagnostik muss unter Beruecksichtigung der klinischen Daten , insbesondere des Alters und v. a. unter Einbeziehung des Verhaltens der Laesionen in den bildgebenden Verfahren erfolgen . Der Pathologe muss ueber Grundkenntnisse in deren Deutung verfuegen . Die angegebenen typischen Fehlinterpretationen sind so ohne Laboraufwand mit dem gewoehnlichen HE-Schnitt zu vermeiden . Instructions: please extract entity words from the input sentence

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Die diagnostische Konsiliartaetigkeit bei Knochentumoren zeigt , dass ausser bei besonders selten vorkommenden Laesionen Schwierigkeiten in der Einstufung Chondrom - Chondrosarkom , in der Beurteilung von reichlich mehrkernige Riesenzellen enthaltenden Prozessen und in der Erkennung von Laesionen mit sekundaeren Zysten , die eine juvenile oder aneurysmatische Zyste simulieren , bestehen , sowie manchmal in der Unterscheidung Kallus vs. Osteosarkom . De-facto-Fehlinterpretationen betreffen ossifizierende Pseudotumore , die als Osteosarkome , metaphysaere fibroese Defekte und Chondroblastome , die als Riesenzelltumoren eingeschaetzt werden , letztere auch als Osteosarkom . Die Knochentumordiagnostik muss unter Beruecksichtigung der klinischen Daten , insbesondere des Alters und v. a. unter Einbeziehung des Verhaltens der Laesionen in den bildgebenden Verfahren erfolgen . Der Pathologe muss ueber Grundkenntnisse in deren Deutung verfuegen . Die angegebenen typischen Fehlinterpretationen sind so ohne Laboraufwand mit dem gewoehnlichen HE-Schnitt zu vermeiden .

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[ "umlsterm" ]

JAK is a GENE-N

23317159_task0

Sentence: JAK inhibitors: pharmacology and clinical activity in chronic myeloprolipherative neoplasms. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N

[ "B-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

JAK inhibitors: pharmacology and clinical activity in chronic myeloprolipherative neoplasms.

[ "JAK", "inhibitors", ":", "pharmacology", "and", "clinical", "activity", "in", "chronic", "myeloprolipherative", "neoplasms", "." ]

[ "GENE-N", "CHEMICAL", "GENE-Y" ]

JAK is a GENE-N

23317159_task1

Sentence: JAK inhibitors: pharmacology and clinical activity in chronic myeloprolipherative neoplasms. Instructions: please typing these entity words according to sentence: JAK Options: GENE-N

[ "B-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

JAK inhibitors: pharmacology and clinical activity in chronic myeloprolipherative neoplasms.

[ "JAK", "inhibitors", ":", "pharmacology", "and", "clinical", "activity", "in", "chronic", "myeloprolipherative", "neoplasms", "." ]

[ "GENE-N", "CHEMICAL", "GENE-Y" ]

JAK

23317159_task2

Sentence: JAK inhibitors: pharmacology and clinical activity in chronic myeloprolipherative neoplasms. Instructions: please extract entity words from the input sentence

[ "B-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

JAK inhibitors: pharmacology and clinical activity in chronic myeloprolipherative neoplasms.

[ "JAK", "inhibitors", ":", "pharmacology", "and", "clinical", "activity", "in", "chronic", "myeloprolipherative", "neoplasms", "." ]

[ "GENE-N", "CHEMICAL", "GENE-Y" ]

woman is an umlsterm, depression is an umlsterm, itching is an umlsterm, John 's is an umlsterm, patchtesting is an umlsterm, testing is an umlsterm, test is an umlsterm, John 's is an umlsterm, medication is an umlsterm

DerHautarzt.70480249.eng.abstr_task0

Sentence: A 61-year-old woman with depression developed recurring elevated itching erythematous lesions in light-exposed areas after taking St. John's Wort-extract for three years . Routine patchtesting did not reveal any relevant reactions and photopatch testing was negative . Using a systemic oral photoprovocation test with St. John's Wort , we were able to demonstrate a decrease of the MED-UVB which was reversible after withdrawal of the medication . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

A 61-year-old woman with depression developed recurring elevated itching erythematous lesions in light-exposed areas after taking St. John's Wort-extract for three years . Routine patchtesting did not reveal any relevant reactions and photopatch testing was negative . Using a systemic oral photoprovocation test with St. John's Wort , we were able to demonstrate a decrease of the MED-UVB which was reversible after withdrawal of the medication .

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[ "umlsterm" ]

woman is an umlsterm, depression is an umlsterm, itching is an umlsterm, John 's is an umlsterm, patchtesting is an umlsterm, testing is an umlsterm, test is an umlsterm, John 's is an umlsterm, medication is an umlsterm

DerHautarzt.70480249.eng.abstr_task1

Sentence: A 61-year-old woman with depression developed recurring elevated itching erythematous lesions in light-exposed areas after taking St. John's Wort-extract for three years . Routine patchtesting did not reveal any relevant reactions and photopatch testing was negative . Using a systemic oral photoprovocation test with St. John's Wort , we were able to demonstrate a decrease of the MED-UVB which was reversible after withdrawal of the medication . Instructions: please typing these entity words according to sentence: woman, depression, itching, John 's, patchtesting, testing, test, John 's, medication Options: umlsterm

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A 61-year-old woman with depression developed recurring elevated itching erythematous lesions in light-exposed areas after taking St. John's Wort-extract for three years . Routine patchtesting did not reveal any relevant reactions and photopatch testing was negative . Using a systemic oral photoprovocation test with St. John's Wort , we were able to demonstrate a decrease of the MED-UVB which was reversible after withdrawal of the medication .

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[ "umlsterm" ]

woman, depression, itching, John 's, patchtesting, testing, test, John 's, medication

DerHautarzt.70480249.eng.abstr_task2

Sentence: A 61-year-old woman with depression developed recurring elevated itching erythematous lesions in light-exposed areas after taking St. John's Wort-extract for three years . Routine patchtesting did not reveal any relevant reactions and photopatch testing was negative . Using a systemic oral photoprovocation test with St. John's Wort , we were able to demonstrate a decrease of the MED-UVB which was reversible after withdrawal of the medication . Instructions: please extract entity words from the input sentence

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A 61-year-old woman with depression developed recurring elevated itching erythematous lesions in light-exposed areas after taking St. John's Wort-extract for three years . Routine patchtesting did not reveal any relevant reactions and photopatch testing was negative . Using a systemic oral photoprovocation test with St. John's Wort , we were able to demonstrate a decrease of the MED-UVB which was reversible after withdrawal of the medication .

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[ "umlsterm" ]

tax is a Protein, interleukin-2 is a Protein, Tax is a Protein, Tax is a Protein, interleukin-2 is a Protein, Tax is a Protein, IL-2 is a Protein, IL-2 is a Protein, Tax is a Protein, Tax is a Protein, Tax is a Protein, Tax is a Protein, Tax is a Protein

9882331_task0

Sentence: Human T-cell leukemia virus type 1 tax protein abrogates interleukin-2 dependence in a mouse T-cell line. Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia. Tax, the viral protein, is thought to be crucial in the development of the disease, since it transforms healthy T cells in vitro and induces tumors in transgenic animals. We examined the effect of Tax activity on the growth of the interleukin-2 (IL-2)-dependent T-cell line CTLL-2. Stable expression of Tax in CTLL-2 transformed cell growth from being IL-2 dependent to IL-2 independent. Tax stimulated transcription through NF-kappaB and the cyclic AMP-responsive element-like sequence in the HTLV-1 promoter. The finding of Tax mutants segregating these two pathways suggested that the NF-kappaB pathway was essential for IL-2-independent growth of CTLL-2 cells while the CRE pathway was unnecessary. However, both pathways were necessary for another transformation-related activity (colony formation in soft agar) of CTLL-2/Tax. Our results show that Tax has at least two distinct activities on T cells, and suggest that Tax plays a crucial role in IL-2-independent T-cell transformation induced by HTLV-1, in addition to its well-known IL-2-dependent cell transformation. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein

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Human T-cell leukemia virus type 1 tax protein abrogates interleukin-2 dependence in a mouse T-cell line. Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia. Tax, the viral protein, is thought to be crucial in the development of the disease, since it transforms healthy T cells in vitro and induces tumors in transgenic animals. We examined the effect of Tax activity on the growth of the interleukin-2 (IL-2)-dependent T-cell line CTLL-2. Stable expression of Tax in CTLL-2 transformed cell growth from being IL-2 dependent to IL-2 independent. Tax stimulated transcription through NF-kappaB and the cyclic AMP-responsive element-like sequence in the HTLV-1 promoter. The finding of Tax mutants segregating these two pathways suggested that the NF-kappaB pathway was essential for IL-2-independent growth of CTLL-2 cells while the CRE pathway was unnecessary. However, both pathways were necessary for another transformation-related activity (colony formation in soft agar) of CTLL-2/Tax. Our results show that Tax has at least two distinct activities on T cells, and suggest that Tax plays a crucial role in IL-2-independent T-cell transformation induced by HTLV-1, in addition to its well-known IL-2-dependent cell transformation.

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[ "Protein" ]

tax is a Protein, interleukin-2 is a Protein, Tax is a Protein, Tax is a Protein, interleukin-2 is a Protein, Tax is a Protein, IL-2 is a Protein, IL-2 is a Protein, Tax is a Protein, Tax is a Protein, Tax is a Protein, Tax is a Protein, Tax is a Protein

9882331_task1

Sentence: Human T-cell leukemia virus type 1 tax protein abrogates interleukin-2 dependence in a mouse T-cell line. Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia. Tax, the viral protein, is thought to be crucial in the development of the disease, since it transforms healthy T cells in vitro and induces tumors in transgenic animals. We examined the effect of Tax activity on the growth of the interleukin-2 (IL-2)-dependent T-cell line CTLL-2. Stable expression of Tax in CTLL-2 transformed cell growth from being IL-2 dependent to IL-2 independent. Tax stimulated transcription through NF-kappaB and the cyclic AMP-responsive element-like sequence in the HTLV-1 promoter. The finding of Tax mutants segregating these two pathways suggested that the NF-kappaB pathway was essential for IL-2-independent growth of CTLL-2 cells while the CRE pathway was unnecessary. However, both pathways were necessary for another transformation-related activity (colony formation in soft agar) of CTLL-2/Tax. Our results show that Tax has at least two distinct activities on T cells, and suggest that Tax plays a crucial role in IL-2-independent T-cell transformation induced by HTLV-1, in addition to its well-known IL-2-dependent cell transformation. Instructions: please typing these entity words according to sentence: tax, interleukin-2, Tax, Tax, interleukin-2, Tax, IL-2, IL-2, Tax, Tax, Tax, Tax, Tax Options: Protein

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Human T-cell leukemia virus type 1 tax protein abrogates interleukin-2 dependence in a mouse T-cell line. Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia. Tax, the viral protein, is thought to be crucial in the development of the disease, since it transforms healthy T cells in vitro and induces tumors in transgenic animals. We examined the effect of Tax activity on the growth of the interleukin-2 (IL-2)-dependent T-cell line CTLL-2. Stable expression of Tax in CTLL-2 transformed cell growth from being IL-2 dependent to IL-2 independent. Tax stimulated transcription through NF-kappaB and the cyclic AMP-responsive element-like sequence in the HTLV-1 promoter. The finding of Tax mutants segregating these two pathways suggested that the NF-kappaB pathway was essential for IL-2-independent growth of CTLL-2 cells while the CRE pathway was unnecessary. However, both pathways were necessary for another transformation-related activity (colony formation in soft agar) of CTLL-2/Tax. Our results show that Tax has at least two distinct activities on T cells, and suggest that Tax plays a crucial role in IL-2-independent T-cell transformation induced by HTLV-1, in addition to its well-known IL-2-dependent cell transformation.

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[ "Protein" ]

tax, interleukin-2, Tax, Tax, interleukin-2, Tax, IL-2, IL-2, Tax, Tax, Tax, Tax, Tax

9882331_task2

Sentence: Human T-cell leukemia virus type 1 tax protein abrogates interleukin-2 dependence in a mouse T-cell line. Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia. Tax, the viral protein, is thought to be crucial in the development of the disease, since it transforms healthy T cells in vitro and induces tumors in transgenic animals. We examined the effect of Tax activity on the growth of the interleukin-2 (IL-2)-dependent T-cell line CTLL-2. Stable expression of Tax in CTLL-2 transformed cell growth from being IL-2 dependent to IL-2 independent. Tax stimulated transcription through NF-kappaB and the cyclic AMP-responsive element-like sequence in the HTLV-1 promoter. The finding of Tax mutants segregating these two pathways suggested that the NF-kappaB pathway was essential for IL-2-independent growth of CTLL-2 cells while the CRE pathway was unnecessary. However, both pathways were necessary for another transformation-related activity (colony formation in soft agar) of CTLL-2/Tax. Our results show that Tax has at least two distinct activities on T cells, and suggest that Tax plays a crucial role in IL-2-independent T-cell transformation induced by HTLV-1, in addition to its well-known IL-2-dependent cell transformation. Instructions: please extract entity words from the input sentence

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Human T-cell leukemia virus type 1 tax protein abrogates interleukin-2 dependence in a mouse T-cell line. Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia. Tax, the viral protein, is thought to be crucial in the development of the disease, since it transforms healthy T cells in vitro and induces tumors in transgenic animals. We examined the effect of Tax activity on the growth of the interleukin-2 (IL-2)-dependent T-cell line CTLL-2. Stable expression of Tax in CTLL-2 transformed cell growth from being IL-2 dependent to IL-2 independent. Tax stimulated transcription through NF-kappaB and the cyclic AMP-responsive element-like sequence in the HTLV-1 promoter. The finding of Tax mutants segregating these two pathways suggested that the NF-kappaB pathway was essential for IL-2-independent growth of CTLL-2 cells while the CRE pathway was unnecessary. However, both pathways were necessary for another transformation-related activity (colony formation in soft agar) of CTLL-2/Tax. Our results show that Tax has at least two distinct activities on T cells, and suggest that Tax plays a crucial role in IL-2-independent T-cell transformation induced by HTLV-1, in addition to its well-known IL-2-dependent cell transformation.

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[ "Protein" ]

syndrome is an umlsterm, proven is an umlsterm, wrist is an umlsterm, pain is an umlsterm, Ulna - shortening is an umlsterm, osteotomy is an umlsterm, therapy is an umlsterm, congenital is an umlsterm, radius fracture is an umlsterm, radius is an umlsterm, congenital is an umlsterm, debridement is an umlsterm, Disorders is an umlsterm, joint is an umlsterm, osteotomy is an umlsterm, treatment is an umlsterm

DerUnfallchirurg.01030197.eng.abstr_task0

Sentence: The ulnar impaction syndrome is proven to be a common source of ulnar sided wrist pain . Ulna-shortening osteotomy represents a successful therapy for this kind of problem , both congenital or posttraumatic positive ulnar variance . Positive variance resulting from a distal radius fracture needs correct dorsal and radial angulation of the radius . In case of congenital positive variance arthroscopic debridement for decompression of the TFCC should be performed first . The adequate correction of the length is the major problem . Disorders of the distal radioulnar joint may result due to overcorrection . Oblique osteotomy using 7-hole-plates is our preferred treatment . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

The ulnar impaction syndrome is proven to be a common source of ulnar sided wrist pain . Ulna-shortening osteotomy represents a successful therapy for this kind of problem , both congenital or posttraumatic positive ulnar variance . Positive variance resulting from a distal radius fracture needs correct dorsal and radial angulation of the radius . In case of congenital positive variance arthroscopic debridement for decompression of the TFCC should be performed first . The adequate correction of the length is the major problem . Disorders of the distal radioulnar joint may result due to overcorrection . Oblique osteotomy using 7-hole-plates is our preferred treatment .

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[ "umlsterm" ]

syndrome is an umlsterm, proven is an umlsterm, wrist is an umlsterm, pain is an umlsterm, Ulna - shortening is an umlsterm, osteotomy is an umlsterm, therapy is an umlsterm, congenital is an umlsterm, radius fracture is an umlsterm, radius is an umlsterm, congenital is an umlsterm, debridement is an umlsterm, Disorders is an umlsterm, joint is an umlsterm, osteotomy is an umlsterm, treatment is an umlsterm

DerUnfallchirurg.01030197.eng.abstr_task1

Sentence: The ulnar impaction syndrome is proven to be a common source of ulnar sided wrist pain . Ulna-shortening osteotomy represents a successful therapy for this kind of problem , both congenital or posttraumatic positive ulnar variance . Positive variance resulting from a distal radius fracture needs correct dorsal and radial angulation of the radius . In case of congenital positive variance arthroscopic debridement for decompression of the TFCC should be performed first . The adequate correction of the length is the major problem . Disorders of the distal radioulnar joint may result due to overcorrection . Oblique osteotomy using 7-hole-plates is our preferred treatment . Instructions: please typing these entity words according to sentence: syndrome, proven, wrist, pain, Ulna - shortening, osteotomy, therapy, congenital, radius fracture, radius, congenital, debridement, Disorders, joint, osteotomy, treatment Options: umlsterm

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The ulnar impaction syndrome is proven to be a common source of ulnar sided wrist pain . Ulna-shortening osteotomy represents a successful therapy for this kind of problem , both congenital or posttraumatic positive ulnar variance . Positive variance resulting from a distal radius fracture needs correct dorsal and radial angulation of the radius . In case of congenital positive variance arthroscopic debridement for decompression of the TFCC should be performed first . The adequate correction of the length is the major problem . Disorders of the distal radioulnar joint may result due to overcorrection . Oblique osteotomy using 7-hole-plates is our preferred treatment .

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[ "umlsterm" ]

syndrome, proven, wrist, pain, Ulna - shortening, osteotomy, therapy, congenital, radius fracture, radius, congenital, debridement, Disorders, joint, osteotomy, treatment

DerUnfallchirurg.01030197.eng.abstr_task2

Sentence: The ulnar impaction syndrome is proven to be a common source of ulnar sided wrist pain . Ulna-shortening osteotomy represents a successful therapy for this kind of problem , both congenital or posttraumatic positive ulnar variance . Positive variance resulting from a distal radius fracture needs correct dorsal and radial angulation of the radius . In case of congenital positive variance arthroscopic debridement for decompression of the TFCC should be performed first . The adequate correction of the length is the major problem . Disorders of the distal radioulnar joint may result due to overcorrection . Oblique osteotomy using 7-hole-plates is our preferred treatment . Instructions: please extract entity words from the input sentence

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The ulnar impaction syndrome is proven to be a common source of ulnar sided wrist pain . Ulna-shortening osteotomy represents a successful therapy for this kind of problem , both congenital or posttraumatic positive ulnar variance . Positive variance resulting from a distal radius fracture needs correct dorsal and radial angulation of the radius . In case of congenital positive variance arthroscopic debridement for decompression of the TFCC should be performed first . The adequate correction of the length is the major problem . Disorders of the distal radioulnar joint may result due to overcorrection . Oblique osteotomy using 7-hole-plates is our preferred treatment .

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[ "umlsterm" ]

N - methyl - D - aspartate receptors is a GENE-N, fibronectin is a GENE-Y

17662248_task0

Sentence: Stimulation of N-methyl-D-aspartate receptors modulates Jurkat T cell growth and adhesion to fibronectin. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, GENE-N

[ "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O" ]

Stimulation of N-methyl-D-aspartate receptors modulates Jurkat T cell growth and adhesion to fibronectin.

[ "Stimulation", "of", "N", "-", "methyl", "-", "D", "-", "aspartate", "receptors", "modulates", "Jurkat", "T", "cell", "growth", "and", "adhesion", "to", "fibronectin", "." ]

[ "CHEMICAL", "GENE-N", "GENE-Y" ]

N - methyl - D - aspartate receptors is a GENE-N, fibronectin is a GENE-Y

17662248_task1

Sentence: Stimulation of N-methyl-D-aspartate receptors modulates Jurkat T cell growth and adhesion to fibronectin. Instructions: please typing these entity words according to sentence: N - methyl - D - aspartate receptors, fibronectin Options: GENE-Y, GENE-N

[ "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O" ]

Stimulation of N-methyl-D-aspartate receptors modulates Jurkat T cell growth and adhesion to fibronectin.

[ "Stimulation", "of", "N", "-", "methyl", "-", "D", "-", "aspartate", "receptors", "modulates", "Jurkat", "T", "cell", "growth", "and", "adhesion", "to", "fibronectin", "." ]

[ "CHEMICAL", "GENE-N", "GENE-Y" ]