bio-datasets/bigbio-ner-merged · Datasets at Hugging Face

answer stringlengths 1 16.1k	id stringlengths 7 56	instruction stringlengths 106 72.6k	ner_tags list	text stringlengths 5 72.4k	tokens list	types list
male is a Person, female is a Person, recipients is a Condition, aged is a Measurement, = 60 is a Value, kidney transplantation is a Procedure, living or deceased donor , is a Scope, Expanded Criteria Donors ( ECD ) is a Qualifier, Panel Reactive Antibody ( PRA ) is a Measurement, < 30 % is a Value	NCT01631058_inc_task0	Sentence: All renal (only) male and female recipients aged = 60, years undergoing kidney transplantation from a living or deceased donor, including Expanded Criteria Donors (ECD). Panel Reactive Antibody (PRA) < 30%. Patients who consented to participate in the study by signing the informed consent form before the transplant surgery to the 1st post-operative day). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Condition, Qualifier, Value, Person, Procedure, Scope, Measurement	[ "O", "O", "O", "O", "O", "B-Person", "O", "B-Person", "B-Condition", "B-Measurement", "B-Value", "I-Value", "O", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	All renal (only) male and female recipients aged = 60, years undergoing kidney transplantation from a living or deceased donor, including Expanded Criteria Donors (ECD). Panel Reactive Antibody (PRA) < 30%. Patients who consented to participate in the study by signing the informed consent form before the transplant surgery to the 1st post-operative day).	[ "All", "renal", "(", "only", ")", "male", "and", "female", "recipients", "aged", "=", "60", ",", "years", "undergoing", "kidney", "transplantation", "from", "a", "living", "or", "deceased", "donor", ",", "including", "Expanded", "Criteria", "Donors", "(", "ECD", ")", ".", "\n", "Panel", "Reactive", "Antibody", "(", "PRA", ")", "<", "30", "%", ".", "\n", "Patients", "who", "consented", "to", "participate", "in", "the", "study", "by", "signing", "the", "informed", "consent", "form", "before", "the", "transplant", "surgery", "to", "the", "1st", "post", "-", "operative", "day", ")", ".", "\n" ]	[ "Qualifier", "Measurement", "Scope", "Procedure", "Condition", "Person", "Value" ]
male is a Person, female is a Person, recipients is a Condition, aged is a Measurement, = 60 is a Value, kidney transplantation is a Procedure, living or deceased donor , is a Scope, Expanded Criteria Donors ( ECD ) is a Qualifier, Panel Reactive Antibody ( PRA ) is a Measurement, < 30 % is a Value	NCT01631058_inc_task1	Sentence: All renal (only) male and female recipients aged = 60, years undergoing kidney transplantation from a living or deceased donor, including Expanded Criteria Donors (ECD). Panel Reactive Antibody (PRA) < 30%. Patients who consented to participate in the study by signing the informed consent form before the transplant surgery to the 1st post-operative day). Instructions: please typing these entity words according to sentence: male, female, recipients, aged, = 60, kidney transplantation, living or deceased donor ,, Expanded Criteria Donors ( ECD ), Panel Reactive Antibody ( PRA ), < 30 % Options: Condition, Qualifier, Value, Person, Procedure, Scope, Measurement	[ "O", "O", "O", "O", "O", "B-Person", "O", "B-Person", "B-Condition", "B-Measurement", "B-Value", "I-Value", "O", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	All renal (only) male and female recipients aged = 60, years undergoing kidney transplantation from a living or deceased donor, including Expanded Criteria Donors (ECD). Panel Reactive Antibody (PRA) < 30%. Patients who consented to participate in the study by signing the informed consent form before the transplant surgery to the 1st post-operative day).	[ "All", "renal", "(", "only", ")", "male", "and", "female", "recipients", "aged", "=", "60", ",", "years", "undergoing", "kidney", "transplantation", "from", "a", "living", "or", "deceased", "donor", ",", "including", "Expanded", "Criteria", "Donors", "(", "ECD", ")", ".", "\n", "Panel", "Reactive", "Antibody", "(", "PRA", ")", "<", "30", "%", ".", "\n", "Patients", "who", "consented", "to", "participate", "in", "the", "study", "by", "signing", "the", "informed", "consent", "form", "before", "the", "transplant", "surgery", "to", "the", "1st", "post", "-", "operative", "day", ")", ".", "\n" ]	[ "Qualifier", "Measurement", "Scope", "Procedure", "Condition", "Person", "Value" ]
male, female, recipients, aged, = 60, kidney transplantation, living or deceased donor ,, Expanded Criteria Donors ( ECD ), Panel Reactive Antibody ( PRA ), < 30 %	NCT01631058_inc_task2	Sentence: All renal (only) male and female recipients aged = 60, years undergoing kidney transplantation from a living or deceased donor, including Expanded Criteria Donors (ECD). Panel Reactive Antibody (PRA) < 30%. Patients who consented to participate in the study by signing the informed consent form before the transplant surgery to the 1st post-operative day). Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "B-Person", "O", "B-Person", "B-Condition", "B-Measurement", "B-Value", "I-Value", "O", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	All renal (only) male and female recipients aged = 60, years undergoing kidney transplantation from a living or deceased donor, including Expanded Criteria Donors (ECD). Panel Reactive Antibody (PRA) < 30%. Patients who consented to participate in the study by signing the informed consent form before the transplant surgery to the 1st post-operative day).	[ "All", "renal", "(", "only", ")", "male", "and", "female", "recipients", "aged", "=", "60", ",", "years", "undergoing", "kidney", "transplantation", "from", "a", "living", "or", "deceased", "donor", ",", "including", "Expanded", "Criteria", "Donors", "(", "ECD", ")", ".", "\n", "Panel", "Reactive", "Antibody", "(", "PRA", ")", "<", "30", "%", ".", "\n", "Patients", "who", "consented", "to", "participate", "in", "the", "study", "by", "signing", "the", "informed", "consent", "form", "before", "the", "transplant", "surgery", "to", "the", "1st", "post", "-", "operative", "day", ")", ".", "\n" ]	[ "Qualifier", "Measurement", "Scope", "Procedure", "Condition", "Person", "Value" ]
ZMPSTE24 is a Gene, LMNA is a Gene, LMNA is a Gene, ZMPSTE24 is a Gene, ZMPSTE24 is a Gene, LMNA is a Gene, ZMPSTE24 is a Gene, LMNA is a Gene	564_task0	Sentence: A homozygous ZMPSTE24 null mutation in combination with a heterozygous mutation in the LMNA gene causes Hutchinson-Gilford progeria syndrome (HGPS): insights into the pathophysiology of HGPS. Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder normally caused by a spontaneous heterozygous mutation in the LMNA gene that codes for the nuclear lamina protein lamin A. Several enzymes are involved in the processing of its precursor, prelamin A, to the mature lamin A. A functional knockout of one of the enzymes involved in prelamin A processing, the zinc metalloprotease ZMPSTE24, causes an even more severe disorder with early neonatal death described as restrictive dermatopathy (RD). This work describes a HGPS patient with a combined defect of a homozygous loss-of-function mutation in the ZMPSTE24 gene and a heterozygous mutation in the LMNA gene that results in a C-terminal elongation of the final lamin A. Whereas the loss of function mutation of ZMPSTE24 normally results in lethal RD, the truncation of LMNA seems to be a salvage alteration alleviating the clinical picture to the HGPS phenotype. The mutations of our patient indicate that farnesylated prelamin A is the deleterious agent leading to the HGPS phenotype, which gives further insights into the pathophysiology of the disorder. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Gene	[ "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	A homozygous ZMPSTE24 null mutation in combination with a heterozygous mutation in the LMNA gene causes Hutchinson-Gilford progeria syndrome (HGPS): insights into the pathophysiology of HGPS. Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder normally caused by a spontaneous heterozygous mutation in the LMNA gene that codes for the nuclear lamina protein lamin A. Several enzymes are involved in the processing of its precursor, prelamin A, to the mature lamin A. A functional knockout of one of the enzymes involved in prelamin A processing, the zinc metalloprotease ZMPSTE24, causes an even more severe disorder with early neonatal death described as restrictive dermatopathy (RD). This work describes a HGPS patient with a combined defect of a homozygous loss-of-function mutation in the ZMPSTE24 gene and a heterozygous mutation in the LMNA gene that results in a C-terminal elongation of the final lamin A. Whereas the loss of function mutation of ZMPSTE24 normally results in lethal RD, the truncation of LMNA seems to be a salvage alteration alleviating the clinical picture to the HGPS phenotype. The mutations of our patient indicate that farnesylated prelamin A is the deleterious agent leading to the HGPS phenotype, which gives further insights into the pathophysiology of the disorder.	[ "A", "homozygous", "ZMPSTE24", "null", "mutation", "in", "combination", "with", "a", "heterozygous", "mutation", "in", "the", "LMNA", "gene", "causes", "Hutchinson", "-", "Gilford", "progeria", "syndrome", "(", "HGPS", "):", "insights", "into", "the", "pathophysiology", "of", "HGPS", ".", "Hutchinson", "-", "Gilford", "progeria", "syndrome", "(", "HGPS", ")", "is", "a", "rare", "premature", "aging", "disorder", "normally", "caused", "by", "a", "spontaneous", "heterozygous", "mutation", "in", "the", "LMNA", "gene", "that", "codes", "for", "the", "nuclear", "lamina", "protein", "lamin", "A.", "Several", "enzymes", "are", "involved", "in", "the", "processing", "of", "its", "precursor", ",", "prelamin", "A", ",", "to", "the", "mature", "lamin", "A.", "A", "functional", "knockout", "of", "one", "of", "the", "enzymes", "involved", "in", "prelamin", "A", "processing", ",", "the", "zinc", "metalloprotease", "ZMPSTE24", ",", "causes", "an", "even", "more", "severe", "disorder", "with", "early", "neonatal", "death", "described", "as", "restrictive", "dermatopathy", "(", "RD", ")", ".", "This", "work", "describes", "a", "HGPS", "patient", "with", "a", "combined", "defect", "of", "a", "homozygous", "loss", "-", "of", "-", "function", "mutation", "in", "the", "ZMPSTE24", "gene", "and", "a", "heterozygous", "mutation", "in", "the", "LMNA", "gene", "that", "results", "in", "a", "C", "-", "terminal", "elongation", "of", "the", "final", "lamin", "A.", "Whereas", "the", "loss", "of", "function", "mutation", "of", "ZMPSTE24", "normally", "results", "in", "lethal", "RD", ",", "the", "truncation", "of", "LMNA", "seems", "to", "be", "a", "salvage", "alteration", "alleviating", "the", "clinical", "picture", "to", "the", "HGPS", "phenotype", ".", "The", "mutations", "of", "our", "patient", "indicate", "that", "farnesylated", "prelamin", "A", "is", "the", "deleterious", "agent", "leading", "to", "the", "HGPS", "phenotype", ",", "which", "gives", "further", "insights", "into", "the", "pathophysiology", "of", "the", "disorder", ".", "\n" ]	[ "Gene" ]
ZMPSTE24 is a Gene, LMNA is a Gene, LMNA is a Gene, ZMPSTE24 is a Gene, ZMPSTE24 is a Gene, LMNA is a Gene, ZMPSTE24 is a Gene, LMNA is a Gene	564_task1	Sentence: A homozygous ZMPSTE24 null mutation in combination with a heterozygous mutation in the LMNA gene causes Hutchinson-Gilford progeria syndrome (HGPS): insights into the pathophysiology of HGPS. Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder normally caused by a spontaneous heterozygous mutation in the LMNA gene that codes for the nuclear lamina protein lamin A. Several enzymes are involved in the processing of its precursor, prelamin A, to the mature lamin A. A functional knockout of one of the enzymes involved in prelamin A processing, the zinc metalloprotease ZMPSTE24, causes an even more severe disorder with early neonatal death described as restrictive dermatopathy (RD). This work describes a HGPS patient with a combined defect of a homozygous loss-of-function mutation in the ZMPSTE24 gene and a heterozygous mutation in the LMNA gene that results in a C-terminal elongation of the final lamin A. Whereas the loss of function mutation of ZMPSTE24 normally results in lethal RD, the truncation of LMNA seems to be a salvage alteration alleviating the clinical picture to the HGPS phenotype. The mutations of our patient indicate that farnesylated prelamin A is the deleterious agent leading to the HGPS phenotype, which gives further insights into the pathophysiology of the disorder. Instructions: please typing these entity words according to sentence: ZMPSTE24, LMNA, LMNA, ZMPSTE24, ZMPSTE24, LMNA, ZMPSTE24, LMNA Options: Gene	[ "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	A homozygous ZMPSTE24 null mutation in combination with a heterozygous mutation in the LMNA gene causes Hutchinson-Gilford progeria syndrome (HGPS): insights into the pathophysiology of HGPS. Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder normally caused by a spontaneous heterozygous mutation in the LMNA gene that codes for the nuclear lamina protein lamin A. Several enzymes are involved in the processing of its precursor, prelamin A, to the mature lamin A. A functional knockout of one of the enzymes involved in prelamin A processing, the zinc metalloprotease ZMPSTE24, causes an even more severe disorder with early neonatal death described as restrictive dermatopathy (RD). This work describes a HGPS patient with a combined defect of a homozygous loss-of-function mutation in the ZMPSTE24 gene and a heterozygous mutation in the LMNA gene that results in a C-terminal elongation of the final lamin A. Whereas the loss of function mutation of ZMPSTE24 normally results in lethal RD, the truncation of LMNA seems to be a salvage alteration alleviating the clinical picture to the HGPS phenotype. The mutations of our patient indicate that farnesylated prelamin A is the deleterious agent leading to the HGPS phenotype, which gives further insights into the pathophysiology of the disorder.	[ "A", "homozygous", "ZMPSTE24", "null", "mutation", "in", "combination", "with", "a", "heterozygous", "mutation", "in", "the", "LMNA", "gene", "causes", "Hutchinson", "-", "Gilford", "progeria", "syndrome", "(", "HGPS", "):", "insights", "into", "the", "pathophysiology", "of", "HGPS", ".", "Hutchinson", "-", "Gilford", "progeria", "syndrome", "(", "HGPS", ")", "is", "a", "rare", "premature", "aging", "disorder", "normally", "caused", "by", "a", "spontaneous", "heterozygous", "mutation", "in", "the", "LMNA", "gene", "that", "codes", "for", "the", "nuclear", "lamina", "protein", "lamin", "A.", "Several", "enzymes", "are", "involved", "in", "the", "processing", "of", "its", "precursor", ",", "prelamin", "A", ",", "to", "the", "mature", "lamin", "A.", "A", "functional", "knockout", "of", "one", "of", "the", "enzymes", "involved", "in", "prelamin", "A", "processing", ",", "the", "zinc", "metalloprotease", "ZMPSTE24", ",", "causes", "an", "even", "more", "severe", "disorder", "with", "early", "neonatal", "death", "described", "as", "restrictive", "dermatopathy", "(", "RD", ")", ".", "This", "work", "describes", "a", "HGPS", "patient", "with", "a", "combined", "defect", "of", "a", "homozygous", "loss", "-", "of", "-", "function", "mutation", "in", "the", "ZMPSTE24", "gene", "and", "a", "heterozygous", "mutation", "in", "the", "LMNA", "gene", "that", "results", "in", "a", "C", "-", "terminal", "elongation", "of", "the", "final", "lamin", "A.", "Whereas", "the", "loss", "of", "function", "mutation", "of", "ZMPSTE24", "normally", "results", "in", "lethal", "RD", ",", "the", "truncation", "of", "LMNA", "seems", "to", "be", "a", "salvage", "alteration", "alleviating", "the", "clinical", "picture", "to", "the", "HGPS", "phenotype", ".", "The", "mutations", "of", "our", "patient", "indicate", "that", "farnesylated", "prelamin", "A", "is", "the", "deleterious", "agent", "leading", "to", "the", "HGPS", "phenotype", ",", "which", "gives", "further", "insights", "into", "the", "pathophysiology", "of", "the", "disorder", ".", "\n" ]	[ "Gene" ]
ZMPSTE24, LMNA, LMNA, ZMPSTE24, ZMPSTE24, LMNA, ZMPSTE24, LMNA	564_task2	Sentence: A homozygous ZMPSTE24 null mutation in combination with a heterozygous mutation in the LMNA gene causes Hutchinson-Gilford progeria syndrome (HGPS): insights into the pathophysiology of HGPS. Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder normally caused by a spontaneous heterozygous mutation in the LMNA gene that codes for the nuclear lamina protein lamin A. Several enzymes are involved in the processing of its precursor, prelamin A, to the mature lamin A. A functional knockout of one of the enzymes involved in prelamin A processing, the zinc metalloprotease ZMPSTE24, causes an even more severe disorder with early neonatal death described as restrictive dermatopathy (RD). This work describes a HGPS patient with a combined defect of a homozygous loss-of-function mutation in the ZMPSTE24 gene and a heterozygous mutation in the LMNA gene that results in a C-terminal elongation of the final lamin A. Whereas the loss of function mutation of ZMPSTE24 normally results in lethal RD, the truncation of LMNA seems to be a salvage alteration alleviating the clinical picture to the HGPS phenotype. The mutations of our patient indicate that farnesylated prelamin A is the deleterious agent leading to the HGPS phenotype, which gives further insights into the pathophysiology of the disorder. Instructions: please extract entity words from the input sentence	[ "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	A homozygous ZMPSTE24 null mutation in combination with a heterozygous mutation in the LMNA gene causes Hutchinson-Gilford progeria syndrome (HGPS): insights into the pathophysiology of HGPS. Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder normally caused by a spontaneous heterozygous mutation in the LMNA gene that codes for the nuclear lamina protein lamin A. Several enzymes are involved in the processing of its precursor, prelamin A, to the mature lamin A. A functional knockout of one of the enzymes involved in prelamin A processing, the zinc metalloprotease ZMPSTE24, causes an even more severe disorder with early neonatal death described as restrictive dermatopathy (RD). This work describes a HGPS patient with a combined defect of a homozygous loss-of-function mutation in the ZMPSTE24 gene and a heterozygous mutation in the LMNA gene that results in a C-terminal elongation of the final lamin A. Whereas the loss of function mutation of ZMPSTE24 normally results in lethal RD, the truncation of LMNA seems to be a salvage alteration alleviating the clinical picture to the HGPS phenotype. The mutations of our patient indicate that farnesylated prelamin A is the deleterious agent leading to the HGPS phenotype, which gives further insights into the pathophysiology of the disorder.	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COL1A2 is a gene	22_task0	Sentence: Collagen type I alpha2 ( COL1A2 ) is the susceptible gene for intracranial aneurysms. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: gene	[ "O", "O", "O", "O", "O", "O", "B-gene", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Collagen type I alpha2 ( COL1A2 ) is the susceptible gene for intracranial aneurysms.	[ "Collagen", "type", "I", "alpha2", " ", "(", "COL1A2", ")", "is", "the", "susceptible", "gene", "for", "intracranial", "aneurysms", "." ]	[ "variant", "gene" ]
COL1A2 is a gene	22_task1	Sentence: Collagen type I alpha2 ( COL1A2 ) is the susceptible gene for intracranial aneurysms. Instructions: please typing these entity words according to sentence: COL1A2 Options: gene	[ "O", "O", "O", "O", "O", "O", "B-gene", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Collagen type I alpha2 ( COL1A2 ) is the susceptible gene for intracranial aneurysms.	[ "Collagen", "type", "I", "alpha2", " ", "(", "COL1A2", ")", "is", "the", "susceptible", "gene", "for", "intracranial", "aneurysms", "." ]	[ "variant", "gene" ]
COL1A2	22_task2	Sentence: Collagen type I alpha2 ( COL1A2 ) is the susceptible gene for intracranial aneurysms. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-gene", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Collagen type I alpha2 ( COL1A2 ) is the susceptible gene for intracranial aneurysms.	[ "Collagen", "type", "I", "alpha2", " ", "(", "COL1A2", ")", "is", "the", "susceptible", "gene", "for", "intracranial", "aneurysms", "." ]	[ "variant", "gene" ]
imidafenacin versus fesoterodine is a Intervention_Pharmacological, overactive bladder . is a Participant_Condition, efficacy and safety is a Outcome_Other, patients with overactive bladder ( OAB ) . is a Participant_Age, fesoterodine - controlled is a Intervention_Control, clinical laboratory tests is a Outcome_Other	62458_task0	Sentence: A randomised , double-blind , parallel design , multi-institutional , non-inferiority phase IV trial of imidafenacin versus fesoterodine for overactive bladder . AIMS Our objective was to compare the efficacy and safety of imidafenacin over fesoterodine in patients with overactive bladder ( OAB ) . METHODS This study is a randomised , double-blind , parallel-group , fesoterodine-controlled study in patients with continuous OAB symptoms for ≥ 3 months , daily mean voiding frequency ( DMVF ) ≥ 8 , and daily mean urgency or urgency incontinence frequency ≥ 2 . A twice-daily 0.1 mg imidafenacin with placebo , or once-daily 4 mg fesoterodine with placebo were administered for 12 weeks . The primary efficacy end-point was the difference in DMVF at 12 weeks . The secondary efficacy end-points were differences in daily mean : ( i ) voiding frequency at 4 and 8 weeks ; ( ii ) urgency frequency ; ( iii ) urgency incontinence frequency ; ( iv ) incontinence frequency ; ( v ) nocturia frequency ; and ( vi ) quality of life score . The variables for safety analysis were adverse events , vital signs , residual urine volume and clinical laboratory tests . An efficacy analysis was conducted in per-protocol patients and the safety analysis was conducted in all randomised patients . RESULTS The differences in DMVF at 12 weeks were -3.38 ± 3.63 and -2.45 ± 3.73 in the imidafenacin and fesoterodine groups , respectively , and the difference was not significant between the two groups . Imidafenacin was non-inferior to fesoterodine , and the lower limit of 95 % two-sided confidence intervals was -0.53 . The other six secondary end-points and variables for safety analysis showed no difference between the two groups . CONCLUSIONS Imidafenacin was non-inferior to fesoterodine in terms of efficacy , and showed no significant difference in terms of safety . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Intervention_Control, Participant_Condition, Participant_Age, Outcome_Other	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	A randomised , double-blind , parallel design , multi-institutional , non-inferiority phase IV trial of imidafenacin versus fesoterodine for overactive bladder . AIMS Our objective was to compare the efficacy and safety of imidafenacin over fesoterodine in patients with overactive bladder ( OAB ) . METHODS This study is a randomised , double-blind , parallel-group , fesoterodine-controlled study in patients with continuous OAB symptoms for ≥ 3 months , daily mean voiding frequency ( DMVF ) ≥ 8 , and daily mean urgency or urgency incontinence frequency ≥ 2 . A twice-daily 0.1 mg imidafenacin with placebo , or once-daily 4 mg fesoterodine with placebo were administered for 12 weeks . The primary efficacy end-point was the difference in DMVF at 12 weeks . The secondary efficacy end-points were differences in daily mean : ( i ) voiding frequency at 4 and 8 weeks ; ( ii ) urgency frequency ; ( iii ) urgency incontinence frequency ; ( iv ) incontinence frequency ; ( v ) nocturia frequency ; and ( vi ) quality of life score . The variables for safety analysis were adverse events , vital signs , residual urine volume and clinical laboratory tests . An efficacy analysis was conducted in per-protocol patients and the safety analysis was conducted in all randomised patients . RESULTS The differences in DMVF at 12 weeks were -3.38 ± 3.63 and -2.45 ± 3.73 in the imidafenacin and fesoterodine groups , respectively , and the difference was not significant between the two groups . Imidafenacin was non-inferior to fesoterodine , and the lower limit of 95 % two-sided confidence intervals was -0.53 . The other six secondary end-points and variables for safety analysis showed no difference between the two groups . CONCLUSIONS Imidafenacin was non-inferior to fesoterodine in terms of efficacy , and showed no significant difference in terms of safety .	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imidafenacin versus fesoterodine is a Intervention_Pharmacological, overactive bladder . is a Participant_Condition, efficacy and safety is a Outcome_Other, patients with overactive bladder ( OAB ) . is a Participant_Age, fesoterodine - controlled is a Intervention_Control, clinical laboratory tests is a Outcome_Other	62458_task1	Sentence: A randomised , double-blind , parallel design , multi-institutional , non-inferiority phase IV trial of imidafenacin versus fesoterodine for overactive bladder . AIMS Our objective was to compare the efficacy and safety of imidafenacin over fesoterodine in patients with overactive bladder ( OAB ) . METHODS This study is a randomised , double-blind , parallel-group , fesoterodine-controlled study in patients with continuous OAB symptoms for ≥ 3 months , daily mean voiding frequency ( DMVF ) ≥ 8 , and daily mean urgency or urgency incontinence frequency ≥ 2 . A twice-daily 0.1 mg imidafenacin with placebo , or once-daily 4 mg fesoterodine with placebo were administered for 12 weeks . The primary efficacy end-point was the difference in DMVF at 12 weeks . The secondary efficacy end-points were differences in daily mean : ( i ) voiding frequency at 4 and 8 weeks ; ( ii ) urgency frequency ; ( iii ) urgency incontinence frequency ; ( iv ) incontinence frequency ; ( v ) nocturia frequency ; and ( vi ) quality of life score . The variables for safety analysis were adverse events , vital signs , residual urine volume and clinical laboratory tests . An efficacy analysis was conducted in per-protocol patients and the safety analysis was conducted in all randomised patients . RESULTS The differences in DMVF at 12 weeks were -3.38 ± 3.63 and -2.45 ± 3.73 in the imidafenacin and fesoterodine groups , respectively , and the difference was not significant between the two groups . Imidafenacin was non-inferior to fesoterodine , and the lower limit of 95 % two-sided confidence intervals was -0.53 . The other six secondary end-points and variables for safety analysis showed no difference between the two groups . CONCLUSIONS Imidafenacin was non-inferior to fesoterodine in terms of efficacy , and showed no significant difference in terms of safety . Instructions: please typing these entity words according to sentence: imidafenacin versus fesoterodine, overactive bladder ., efficacy and safety, patients with overactive bladder ( OAB ) ., fesoterodine - controlled, clinical laboratory tests Options: Intervention_Pharmacological, Intervention_Control, Participant_Condition, Participant_Age, Outcome_Other	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	A randomised , double-blind , parallel design , multi-institutional , non-inferiority phase IV trial of imidafenacin versus fesoterodine for overactive bladder . AIMS Our objective was to compare the efficacy and safety of imidafenacin over fesoterodine in patients with overactive bladder ( OAB ) . METHODS This study is a randomised , double-blind , parallel-group , fesoterodine-controlled study in patients with continuous OAB symptoms for ≥ 3 months , daily mean voiding frequency ( DMVF ) ≥ 8 , and daily mean urgency or urgency incontinence frequency ≥ 2 . A twice-daily 0.1 mg imidafenacin with placebo , or once-daily 4 mg fesoterodine with placebo were administered for 12 weeks . The primary efficacy end-point was the difference in DMVF at 12 weeks . The secondary efficacy end-points were differences in daily mean : ( i ) voiding frequency at 4 and 8 weeks ; ( ii ) urgency frequency ; ( iii ) urgency incontinence frequency ; ( iv ) incontinence frequency ; ( v ) nocturia frequency ; and ( vi ) quality of life score . The variables for safety analysis were adverse events , vital signs , residual urine volume and clinical laboratory tests . An efficacy analysis was conducted in per-protocol patients and the safety analysis was conducted in all randomised patients . RESULTS The differences in DMVF at 12 weeks were -3.38 ± 3.63 and -2.45 ± 3.73 in the imidafenacin and fesoterodine groups , respectively , and the difference was not significant between the two groups . Imidafenacin was non-inferior to fesoterodine , and the lower limit of 95 % two-sided confidence intervals was -0.53 . The other six secondary end-points and variables for safety analysis showed no difference between the two groups . CONCLUSIONS Imidafenacin was non-inferior to fesoterodine in terms of efficacy , and showed no significant difference in terms of safety .	[ "A", "randomised", ",", "double", "-", "blind", ",", "parallel", "design", ",", "multi", "-", "institutional", ",", "non", "-", "inferiority", "phase", "IV", "trial", "of", "imidafenacin", "versus", "fesoterodine", "for", "overactive", "bladder", ".", "AIMS", "Our", "objective", "was", "to", "compare", "the", "efficacy", "and", "safety", "of", "imidafenacin", "over", "fesoterodine", "in", "patients", "with", "overactive", "bladder", "(", "OAB", ")", ".", "METHODS", "This", "study", "is", "a", "randomised", ",", "double", "-", "blind", ",", "parallel", "-", "group", ",", "fesoterodine", "-", "controlled", "study", "in", "patients", "with", "continuous", "OAB", "symptoms", "for", "≥", "3", "months", ",", "daily", "mean", "voiding", "frequency", "(", "DMVF", ")", "≥", "8", ",", "and", "daily", "mean", "urgency", "or", "urgency", "incontinence", "frequency", "≥", "2", ".", "A", "twice", "-", "daily", "0.1", "mg", "imidafenacin", "with", "placebo", ",", "or", "once", "-", "daily", "4", "mg", "fesoterodine", "with", "placebo", "were", "administered", "for", "12", "weeks", ".", "The", "primary", "efficacy", "end", "-", "point", "was", "the", "difference", "in", "DMVF", "at", "12", "weeks", ".", "The", "secondary", "efficacy", "end", "-", "points", "were", "differences", "in", "daily", "mean", ":", "(", "i", ")", "voiding", "frequency", "at", "4", "and", "8", "weeks", ";", "(", "ii", ")", "urgency", "frequency", ";", "(", "iii", ")", "urgency", "incontinence", "frequency", ";", "(", "iv", ")", "incontinence", "frequency", ";", "(", "v", ")", "nocturia", "frequency", ";", "and", "(", "vi", ")", "quality", "of", "life", "score", ".", "The", "variables", "for", "safety", "analysis", "were", "adverse", "events", ",", "vital", "signs", ",", "residual", "urine", "volume", "and", "clinical", "laboratory", "tests", ".", "An", "efficacy", "analysis", "was", "conducted", "in", "per", "-", "protocol", "patients", "and", "the", "safety", "analysis", "was", "conducted", "in", "all", "randomised", "patients", ".", "RESULTS", "The", "differences", "in", "DMVF", "at", "12", "weeks", "were", "-3.38", "±", "3.63", "and", "-2.45", "±", "3.73", "in", "the", "imidafenacin", "and", "fesoterodine", "groups", ",", "respectively", ",", "and", "the", "difference", "was", "not", "significant", "between", "the", "two", "groups", ".", "Imidafenacin", "was", "non", "-", "inferior", "to", "fesoterodine", ",", "and", "the", "lower", "limit", "of", "95", "%", "two", "-", "sided", "confidence", "intervals", "was", "-0.53", ".", "The", "other", "six", "secondary", "end", "-", "points", "and", "variables", "for", "safety", "analysis", "showed", "no", "difference", "between", "the", "two", "groups", ".", "CONCLUSIONS", "Imidafenacin", "was", "non", "-", "inferior", "to", "fesoterodine", "in", "terms", "of", "efficacy", ",", "and", "showed", "no", "significant", "difference", "in", "terms", "of", "safety", "." ]	[ "Participant_Age", "Intervention_Pharmacological", "Outcome_Other", "Intervention_Control", "Participant_Condition" ]
imidafenacin versus fesoterodine, overactive bladder ., efficacy and safety, patients with overactive bladder ( OAB ) ., fesoterodine - controlled, clinical laboratory tests	62458_task2	Sentence: A randomised , double-blind , parallel design , multi-institutional , non-inferiority phase IV trial of imidafenacin versus fesoterodine for overactive bladder . AIMS Our objective was to compare the efficacy and safety of imidafenacin over fesoterodine in patients with overactive bladder ( OAB ) . METHODS This study is a randomised , double-blind , parallel-group , fesoterodine-controlled study in patients with continuous OAB symptoms for ≥ 3 months , daily mean voiding frequency ( DMVF ) ≥ 8 , and daily mean urgency or urgency incontinence frequency ≥ 2 . A twice-daily 0.1 mg imidafenacin with placebo , or once-daily 4 mg fesoterodine with placebo were administered for 12 weeks . The primary efficacy end-point was the difference in DMVF at 12 weeks . The secondary efficacy end-points were differences in daily mean : ( i ) voiding frequency at 4 and 8 weeks ; ( ii ) urgency frequency ; ( iii ) urgency incontinence frequency ; ( iv ) incontinence frequency ; ( v ) nocturia frequency ; and ( vi ) quality of life score . The variables for safety analysis were adverse events , vital signs , residual urine volume and clinical laboratory tests . An efficacy analysis was conducted in per-protocol patients and the safety analysis was conducted in all randomised patients . RESULTS The differences in DMVF at 12 weeks were -3.38 ± 3.63 and -2.45 ± 3.73 in the imidafenacin and fesoterodine groups , respectively , and the difference was not significant between the two groups . Imidafenacin was non-inferior to fesoterodine , and the lower limit of 95 % two-sided confidence intervals was -0.53 . The other six secondary end-points and variables for safety analysis showed no difference between the two groups . CONCLUSIONS Imidafenacin was non-inferior to fesoterodine in terms of efficacy , and showed no significant difference in terms of safety . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	A randomised , double-blind , parallel design , multi-institutional , non-inferiority phase IV trial of imidafenacin versus fesoterodine for overactive bladder . AIMS Our objective was to compare the efficacy and safety of imidafenacin over fesoterodine in patients with overactive bladder ( OAB ) . METHODS This study is a randomised , double-blind , parallel-group , fesoterodine-controlled study in patients with continuous OAB symptoms for ≥ 3 months , daily mean voiding frequency ( DMVF ) ≥ 8 , and daily mean urgency or urgency incontinence frequency ≥ 2 . A twice-daily 0.1 mg imidafenacin with placebo , or once-daily 4 mg fesoterodine with placebo were administered for 12 weeks . The primary efficacy end-point was the difference in DMVF at 12 weeks . The secondary efficacy end-points were differences in daily mean : ( i ) voiding frequency at 4 and 8 weeks ; ( ii ) urgency frequency ; ( iii ) urgency incontinence frequency ; ( iv ) incontinence frequency ; ( v ) nocturia frequency ; and ( vi ) quality of life score . The variables for safety analysis were adverse events , vital signs , residual urine volume and clinical laboratory tests . An efficacy analysis was conducted in per-protocol patients and the safety analysis was conducted in all randomised patients . RESULTS The differences in DMVF at 12 weeks were -3.38 ± 3.63 and -2.45 ± 3.73 in the imidafenacin and fesoterodine groups , respectively , and the difference was not significant between the two groups . Imidafenacin was non-inferior to fesoterodine , and the lower limit of 95 % two-sided confidence intervals was -0.53 . The other six secondary end-points and variables for safety analysis showed no difference between the two groups . CONCLUSIONS Imidafenacin was non-inferior to fesoterodine in terms of efficacy , and showed no significant difference in terms of safety .	[ "A", "randomised", ",", "double", "-", "blind", ",", "parallel", "design", ",", "multi", "-", "institutional", ",", "non", "-", "inferiority", "phase", "IV", "trial", "of", "imidafenacin", "versus", "fesoterodine", "for", "overactive", "bladder", ".", "AIMS", "Our", "objective", "was", "to", "compare", "the", "efficacy", "and", "safety", "of", "imidafenacin", "over", "fesoterodine", "in", "patients", "with", "overactive", "bladder", "(", "OAB", ")", ".", "METHODS", "This", "study", "is", "a", "randomised", ",", "double", "-", "blind", ",", "parallel", "-", "group", ",", "fesoterodine", "-", "controlled", "study", "in", "patients", "with", "continuous", "OAB", "symptoms", "for", "≥", "3", "months", ",", "daily", "mean", "voiding", "frequency", "(", "DMVF", ")", "≥", "8", ",", "and", "daily", "mean", "urgency", "or", "urgency", "incontinence", "frequency", "≥", "2", ".", "A", "twice", "-", "daily", "0.1", "mg", "imidafenacin", "with", "placebo", ",", "or", "once", "-", "daily", "4", "mg", "fesoterodine", "with", "placebo", "were", "administered", "for", "12", "weeks", ".", "The", "primary", "efficacy", "end", "-", "point", "was", "the", "difference", "in", "DMVF", "at", "12", "weeks", ".", "The", "secondary", "efficacy", "end", "-", "points", "were", "differences", "in", "daily", "mean", ":", "(", "i", ")", "voiding", "frequency", "at", "4", "and", "8", "weeks", ";", "(", "ii", ")", "urgency", "frequency", ";", "(", "iii", ")", "urgency", "incontinence", "frequency", ";", "(", "iv", ")", "incontinence", "frequency", ";", "(", "v", ")", "nocturia", "frequency", ";", "and", "(", "vi", ")", "quality", "of", "life", "score", ".", "The", "variables", "for", "safety", "analysis", "were", "adverse", "events", ",", "vital", "signs", ",", "residual", "urine", "volume", "and", "clinical", "laboratory", "tests", ".", "An", "efficacy", "analysis", "was", "conducted", "in", "per", "-", "protocol", "patients", "and", "the", "safety", "analysis", "was", "conducted", "in", "all", "randomised", "patients", ".", "RESULTS", "The", "differences", "in", "DMVF", "at", "12", "weeks", "were", "-3.38", "±", "3.63", "and", "-2.45", "±", "3.73", "in", "the", "imidafenacin", "and", "fesoterodine", "groups", ",", "respectively", ",", "and", "the", "difference", "was", "not", "significant", "between", "the", "two", "groups", ".", "Imidafenacin", "was", "non", "-", "inferior", "to", "fesoterodine", ",", "and", "the", "lower", "limit", "of", "95", "%", "two", "-", "sided", "confidence", "intervals", "was", "-0.53", ".", "The", "other", "six", "secondary", "end", "-", "points", "and", "variables", "for", "safety", "analysis", "showed", "no", "difference", "between", "the", "two", "groups", ".", "CONCLUSIONS", "Imidafenacin", "was", "non", "-", "inferior", "to", "fesoterodine", "in", "terms", "of", "efficacy", ",", "and", "showed", "no", "significant", "difference", "in", "terms", "of", "safety", "." ]	[ "Participant_Age", "Intervention_Pharmacological", "Outcome_Other", "Intervention_Control", "Participant_Condition" ]
memantine is a CHEMICAL	14530799_task0	Sentence: The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL	[ "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O" ]	The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease.	[ "The", "neuropharmacological", "basis", "for", "the", "use", "of", "memantine", "in", "the", "treatment", "of", "Alzheimer", "'s", "disease", "." ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
memantine is a CHEMICAL	14530799_task1	Sentence: The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease. Instructions: please typing these entity words according to sentence: memantine Options: CHEMICAL	[ "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O" ]	The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease.	[ "The", "neuropharmacological", "basis", "for", "the", "use", "of", "memantine", "in", "the", "treatment", "of", "Alzheimer", "'s", "disease", "." ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
memantine	14530799_task2	Sentence: The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O" ]	The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease.	[ "The", "neuropharmacological", "basis", "for", "the", "use", "of", "memantine", "in", "the", "treatment", "of", "Alzheimer", "'s", "disease", "." ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
Papillomviren is an umlsterm, Karzinomen is an umlsterm, Impfstoffes is an umlsterm, krebsassoziierte is an umlsterm, therapeutischen Anwendung is an umlsterm, Vakzine is an umlsterm, Infektion is an umlsterm, Antikoerper is an umlsterm, Tiermodell is an umlsterm, Papillomviren is an umlsterm, Wirtszelle is an umlsterm, Antikoerper is an umlsterm, virusaehnliche is an umlsterm, Strukturproteinen is an umlsterm, Impfstoff is an umlsterm, Fruehproteine is an umlsterm, Papillomviren is an umlsterm, Epidermis is an umlsterm, Antigen is an umlsterm, T - Zellen is an umlsterm, Peptiden is an umlsterm, Impfstoff is an umlsterm	DerHautarzt.60470739.ger.abstr_task0	Sentence: Humane Papillomviren ( HPV ) sind Ursache haeufiger epithelialer Proliferationen und an der Entstehung von anogenitalen Karzinomen wesentlich beteiligt . Bei der Entwicklung eines Impfstoffes gegen krebsassoziierte HPV wird infolge zweier grundsaetzlicher Ziele sowohl in Richtung der Prophylaxe als auch einer therapeutischen Anwendung gearbeitet . Eine Vakzine zur Verhinderung einer Infektion mit HPV scheint in naher Zukunft herstellbar . Antikoerper gegen dreidimensionale Kapsidstrukturen schuetzen im Tiermodell vor dem Eindringen der Papillomviren in die Wirtszelle , und diese wichtigen neutralisierenden Antikoerper koennen durch DNA-freie virusaehnliche Kapsidpartikel aus spontan rearrangierten Strukturproteinen induziert werden . Solche Partikel gelten deshalb als sicherer , prophylaktisch wirksamer Impfstoff . Eine ideale HPV-Vakzine sollte zusaetzlich die durch zellulaere Immunmechanismen vermittelte Rueckbildung von bereits bestehenden praekanzeroesen und auch von malignen Laesionen vermitteln . Die transformierenden Fruehproteine der Papillomviren , die in Basalzellen der Epidermis als ein hypothetisches Antigen spezifischer T-Zellen exprimiert sind , koennten in Form von synthetischen Peptiden fuer einen solchen Impfstoff eingesetzt werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	Humane Papillomviren ( HPV ) sind Ursache haeufiger epithelialer Proliferationen und an der Entstehung von anogenitalen Karzinomen wesentlich beteiligt . Bei der Entwicklung eines Impfstoffes gegen krebsassoziierte HPV wird infolge zweier grundsaetzlicher Ziele sowohl in Richtung der Prophylaxe als auch einer therapeutischen Anwendung gearbeitet . Eine Vakzine zur Verhinderung einer Infektion mit HPV scheint in naher Zukunft herstellbar . Antikoerper gegen dreidimensionale Kapsidstrukturen schuetzen im Tiermodell vor dem Eindringen der Papillomviren in die Wirtszelle , und diese wichtigen neutralisierenden Antikoerper koennen durch DNA-freie virusaehnliche Kapsidpartikel aus spontan rearrangierten Strukturproteinen induziert werden . Solche Partikel gelten deshalb als sicherer , prophylaktisch wirksamer Impfstoff . Eine ideale HPV-Vakzine sollte zusaetzlich die durch zellulaere Immunmechanismen vermittelte Rueckbildung von bereits bestehenden praekanzeroesen und auch von malignen Laesionen vermitteln . Die transformierenden Fruehproteine der Papillomviren , die in Basalzellen der Epidermis als ein hypothetisches Antigen spezifischer T-Zellen exprimiert sind , koennten in Form von synthetischen Peptiden fuer einen solchen Impfstoff eingesetzt werden .	[ "Humane", "Papillomviren", "(", "HPV", ")", "sind", "Ursache", "haeufiger", "epithelialer", "Proliferationen", "und", "an", "der", "Entstehung", "von", "anogenitalen", "Karzinomen", "wesentlich", "beteiligt", ".", "Bei", "der", "Entwicklung", "eines", "Impfstoffes", "gegen", "krebsassoziierte", "HPV", "wird", "infolge", "zweier", "grundsaetzlicher", "Ziele", "sowohl", "in", "Richtung", "der", "Prophylaxe", "als", "auch", "einer", "therapeutischen", "Anwendung", "gearbeitet", ".", "Eine", "Vakzine", "zur", "Verhinderung", "einer", "Infektion", "mit", "HPV", "scheint", "in", "naher", "Zukunft", "herstellbar", ".", "Antikoerper", "gegen", "dreidimensionale", "Kapsidstrukturen", "schuetzen", "im", "Tiermodell", "vor", "dem", "Eindringen", "der", "Papillomviren", "in", "die", "Wirtszelle", ",", "und", "diese", "wichtigen", "neutralisierenden", "Antikoerper", "koennen", "durch", "DNA", "-", "freie", "virusaehnliche", "Kapsidpartikel", "aus", "spontan", "rearrangierten", "Strukturproteinen", "induziert", "werden", ".", "Solche", "Partikel", "gelten", "deshalb", "als", "sicherer", ",", "prophylaktisch", "wirksamer", "Impfstoff", ".", "Eine", "ideale", "HPV", "-", "Vakzine", "sollte", "zusaetzlich", "die", "durch", "zellulaere", "Immunmechanismen", "vermittelte", "Rueckbildung", "von", "bereits", "bestehenden", "praekanzeroesen", "und", "auch", "von", "malignen", "Laesionen", "vermitteln", ".", "Die", "transformierenden", "Fruehproteine", "der", "Papillomviren", ",", "die", "in", "Basalzellen", "der", "Epidermis", "als", "ein", "hypothetisches", "Antigen", "spezifischer", "T", "-", "Zellen", "exprimiert", "sind", ",", "koennten", "in", "Form", "von", "synthetischen", "Peptiden", "fuer", "einen", "solchen", "Impfstoff", "eingesetzt", "werden", "." ]	[ "umlsterm" ]
Papillomviren is an umlsterm, Karzinomen is an umlsterm, Impfstoffes is an umlsterm, krebsassoziierte is an umlsterm, therapeutischen Anwendung is an umlsterm, Vakzine is an umlsterm, Infektion is an umlsterm, Antikoerper is an umlsterm, Tiermodell is an umlsterm, Papillomviren is an umlsterm, Wirtszelle is an umlsterm, Antikoerper is an umlsterm, virusaehnliche is an umlsterm, Strukturproteinen is an umlsterm, Impfstoff is an umlsterm, Fruehproteine is an umlsterm, Papillomviren is an umlsterm, Epidermis is an umlsterm, Antigen is an umlsterm, T - Zellen is an umlsterm, Peptiden is an umlsterm, Impfstoff is an umlsterm	DerHautarzt.60470739.ger.abstr_task1	Sentence: Humane Papillomviren ( HPV ) sind Ursache haeufiger epithelialer Proliferationen und an der Entstehung von anogenitalen Karzinomen wesentlich beteiligt . Bei der Entwicklung eines Impfstoffes gegen krebsassoziierte HPV wird infolge zweier grundsaetzlicher Ziele sowohl in Richtung der Prophylaxe als auch einer therapeutischen Anwendung gearbeitet . Eine Vakzine zur Verhinderung einer Infektion mit HPV scheint in naher Zukunft herstellbar . Antikoerper gegen dreidimensionale Kapsidstrukturen schuetzen im Tiermodell vor dem Eindringen der Papillomviren in die Wirtszelle , und diese wichtigen neutralisierenden Antikoerper koennen durch DNA-freie virusaehnliche Kapsidpartikel aus spontan rearrangierten Strukturproteinen induziert werden . Solche Partikel gelten deshalb als sicherer , prophylaktisch wirksamer Impfstoff . Eine ideale HPV-Vakzine sollte zusaetzlich die durch zellulaere Immunmechanismen vermittelte Rueckbildung von bereits bestehenden praekanzeroesen und auch von malignen Laesionen vermitteln . Die transformierenden Fruehproteine der Papillomviren , die in Basalzellen der Epidermis als ein hypothetisches Antigen spezifischer T-Zellen exprimiert sind , koennten in Form von synthetischen Peptiden fuer einen solchen Impfstoff eingesetzt werden . Instructions: please typing these entity words according to sentence: Papillomviren, Karzinomen, Impfstoffes, krebsassoziierte, therapeutischen Anwendung, Vakzine, Infektion, Antikoerper, Tiermodell, Papillomviren, Wirtszelle, Antikoerper, virusaehnliche, Strukturproteinen, Impfstoff, Fruehproteine, Papillomviren, Epidermis, Antigen, T - Zellen, Peptiden, Impfstoff Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	Humane Papillomviren ( HPV ) sind Ursache haeufiger epithelialer Proliferationen und an der Entstehung von anogenitalen Karzinomen wesentlich beteiligt . Bei der Entwicklung eines Impfstoffes gegen krebsassoziierte HPV wird infolge zweier grundsaetzlicher Ziele sowohl in Richtung der Prophylaxe als auch einer therapeutischen Anwendung gearbeitet . Eine Vakzine zur Verhinderung einer Infektion mit HPV scheint in naher Zukunft herstellbar . Antikoerper gegen dreidimensionale Kapsidstrukturen schuetzen im Tiermodell vor dem Eindringen der Papillomviren in die Wirtszelle , und diese wichtigen neutralisierenden Antikoerper koennen durch DNA-freie virusaehnliche Kapsidpartikel aus spontan rearrangierten Strukturproteinen induziert werden . Solche Partikel gelten deshalb als sicherer , prophylaktisch wirksamer Impfstoff . Eine ideale HPV-Vakzine sollte zusaetzlich die durch zellulaere Immunmechanismen vermittelte Rueckbildung von bereits bestehenden praekanzeroesen und auch von malignen Laesionen vermitteln . Die transformierenden Fruehproteine der Papillomviren , die in Basalzellen der Epidermis als ein hypothetisches Antigen spezifischer T-Zellen exprimiert sind , koennten in Form von synthetischen Peptiden fuer einen solchen Impfstoff eingesetzt werden .	[ "Humane", "Papillomviren", "(", "HPV", ")", "sind", "Ursache", "haeufiger", "epithelialer", "Proliferationen", "und", "an", "der", "Entstehung", "von", "anogenitalen", "Karzinomen", "wesentlich", "beteiligt", ".", "Bei", "der", "Entwicklung", "eines", "Impfstoffes", "gegen", "krebsassoziierte", "HPV", "wird", "infolge", "zweier", "grundsaetzlicher", "Ziele", "sowohl", "in", "Richtung", "der", "Prophylaxe", "als", "auch", "einer", "therapeutischen", "Anwendung", "gearbeitet", ".", "Eine", "Vakzine", "zur", "Verhinderung", "einer", "Infektion", "mit", "HPV", "scheint", "in", "naher", "Zukunft", "herstellbar", ".", "Antikoerper", "gegen", "dreidimensionale", "Kapsidstrukturen", "schuetzen", "im", "Tiermodell", "vor", "dem", "Eindringen", "der", "Papillomviren", "in", "die", "Wirtszelle", ",", "und", "diese", "wichtigen", "neutralisierenden", "Antikoerper", "koennen", "durch", "DNA", "-", "freie", "virusaehnliche", "Kapsidpartikel", "aus", "spontan", "rearrangierten", "Strukturproteinen", "induziert", "werden", ".", "Solche", "Partikel", "gelten", "deshalb", "als", "sicherer", ",", "prophylaktisch", "wirksamer", "Impfstoff", ".", "Eine", "ideale", "HPV", "-", "Vakzine", "sollte", "zusaetzlich", "die", "durch", "zellulaere", "Immunmechanismen", "vermittelte", "Rueckbildung", "von", "bereits", "bestehenden", "praekanzeroesen", "und", "auch", "von", "malignen", "Laesionen", "vermitteln", ".", "Die", "transformierenden", "Fruehproteine", "der", "Papillomviren", ",", "die", "in", "Basalzellen", "der", "Epidermis", "als", "ein", "hypothetisches", "Antigen", "spezifischer", "T", "-", "Zellen", "exprimiert", "sind", ",", "koennten", "in", "Form", "von", "synthetischen", "Peptiden", "fuer", "einen", "solchen", "Impfstoff", "eingesetzt", "werden", "." ]	[ "umlsterm" ]
Papillomviren, Karzinomen, Impfstoffes, krebsassoziierte, therapeutischen Anwendung, Vakzine, Infektion, Antikoerper, Tiermodell, Papillomviren, Wirtszelle, Antikoerper, virusaehnliche, Strukturproteinen, Impfstoff, Fruehproteine, Papillomviren, Epidermis, Antigen, T - Zellen, Peptiden, Impfstoff	DerHautarzt.60470739.ger.abstr_task2	Sentence: Humane Papillomviren ( HPV ) sind Ursache haeufiger epithelialer Proliferationen und an der Entstehung von anogenitalen Karzinomen wesentlich beteiligt . Bei der Entwicklung eines Impfstoffes gegen krebsassoziierte HPV wird infolge zweier grundsaetzlicher Ziele sowohl in Richtung der Prophylaxe als auch einer therapeutischen Anwendung gearbeitet . Eine Vakzine zur Verhinderung einer Infektion mit HPV scheint in naher Zukunft herstellbar . Antikoerper gegen dreidimensionale Kapsidstrukturen schuetzen im Tiermodell vor dem Eindringen der Papillomviren in die Wirtszelle , und diese wichtigen neutralisierenden Antikoerper koennen durch DNA-freie virusaehnliche Kapsidpartikel aus spontan rearrangierten Strukturproteinen induziert werden . Solche Partikel gelten deshalb als sicherer , prophylaktisch wirksamer Impfstoff . Eine ideale HPV-Vakzine sollte zusaetzlich die durch zellulaere Immunmechanismen vermittelte Rueckbildung von bereits bestehenden praekanzeroesen und auch von malignen Laesionen vermitteln . Die transformierenden Fruehproteine der Papillomviren , die in Basalzellen der Epidermis als ein hypothetisches Antigen spezifischer T-Zellen exprimiert sind , koennten in Form von synthetischen Peptiden fuer einen solchen Impfstoff eingesetzt werden . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	Humane Papillomviren ( HPV ) sind Ursache haeufiger epithelialer Proliferationen und an der Entstehung von anogenitalen Karzinomen wesentlich beteiligt . Bei der Entwicklung eines Impfstoffes gegen krebsassoziierte HPV wird infolge zweier grundsaetzlicher Ziele sowohl in Richtung der Prophylaxe als auch einer therapeutischen Anwendung gearbeitet . Eine Vakzine zur Verhinderung einer Infektion mit HPV scheint in naher Zukunft herstellbar . Antikoerper gegen dreidimensionale Kapsidstrukturen schuetzen im Tiermodell vor dem Eindringen der Papillomviren in die Wirtszelle , und diese wichtigen neutralisierenden Antikoerper koennen durch DNA-freie virusaehnliche Kapsidpartikel aus spontan rearrangierten Strukturproteinen induziert werden . Solche Partikel gelten deshalb als sicherer , prophylaktisch wirksamer Impfstoff . Eine ideale HPV-Vakzine sollte zusaetzlich die durch zellulaere Immunmechanismen vermittelte Rueckbildung von bereits bestehenden praekanzeroesen und auch von malignen Laesionen vermitteln . Die transformierenden Fruehproteine der Papillomviren , die in Basalzellen der Epidermis als ein hypothetisches Antigen spezifischer T-Zellen exprimiert sind , koennten in Form von synthetischen Peptiden fuer einen solchen Impfstoff eingesetzt werden .	[ "Humane", "Papillomviren", "(", "HPV", ")", "sind", "Ursache", "haeufiger", "epithelialer", "Proliferationen", "und", "an", "der", "Entstehung", "von", "anogenitalen", "Karzinomen", "wesentlich", "beteiligt", ".", "Bei", "der", "Entwicklung", "eines", "Impfstoffes", "gegen", "krebsassoziierte", "HPV", "wird", "infolge", "zweier", "grundsaetzlicher", "Ziele", "sowohl", "in", "Richtung", "der", "Prophylaxe", "als", "auch", "einer", "therapeutischen", "Anwendung", "gearbeitet", ".", "Eine", "Vakzine", "zur", "Verhinderung", "einer", "Infektion", "mit", "HPV", "scheint", "in", "naher", "Zukunft", "herstellbar", ".", "Antikoerper", "gegen", "dreidimensionale", "Kapsidstrukturen", "schuetzen", "im", "Tiermodell", "vor", "dem", "Eindringen", "der", "Papillomviren", "in", "die", "Wirtszelle", ",", "und", "diese", "wichtigen", "neutralisierenden", "Antikoerper", "koennen", "durch", "DNA", "-", "freie", "virusaehnliche", "Kapsidpartikel", "aus", "spontan", "rearrangierten", "Strukturproteinen", "induziert", "werden", ".", "Solche", "Partikel", "gelten", "deshalb", "als", "sicherer", ",", "prophylaktisch", "wirksamer", "Impfstoff", ".", "Eine", "ideale", "HPV", "-", "Vakzine", "sollte", "zusaetzlich", "die", "durch", "zellulaere", "Immunmechanismen", "vermittelte", "Rueckbildung", "von", "bereits", "bestehenden", "praekanzeroesen", "und", "auch", "von", "malignen", "Laesionen", "vermitteln", ".", "Die", "transformierenden", "Fruehproteine", "der", "Papillomviren", ",", "die", "in", "Basalzellen", "der", "Epidermis", "als", "ein", "hypothetisches", "Antigen", "spezifischer", "T", "-", "Zellen", "exprimiert", "sind", ",", "koennten", "in", "Form", "von", "synthetischen", "Peptiden", "fuer", "einen", "solchen", "Impfstoff", "eingesetzt", "werden", "." ]	[ "umlsterm" ]
Abstract is an umlsterm, clinical investigation is an umlsterm, sevoflurane is an umlsterm, degradation is an umlsterm, lithiumhydroxide is an umlsterm, carbon dioxide is an umlsterm, absorption is an umlsterm	DerAnaesthesist.00490106.eng.abstr_task0	Sentence: Abstract Aim of the study was the clinical investigation of sevoflurane degradation when using water-free lithiumhydroxide versus moist Draegersorb 800 for carbon dioxide absorption . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O" ]	Abstract Aim of the study was the clinical investigation of sevoflurane degradation when using water-free lithiumhydroxide versus moist Draegersorb 800 for carbon dioxide absorption .	[ "Abstract", "Aim", "of", "the", "study", "was", "the", "clinical", "investigation", "of", "sevoflurane", "degradation", "when", "using", "water", "-", "free", "lithiumhydroxide", "versus", "moist", "Draegersorb", "800", "for", "carbon", "dioxide", "absorption", "." ]	[ "umlsterm" ]
Abstract is an umlsterm, clinical investigation is an umlsterm, sevoflurane is an umlsterm, degradation is an umlsterm, lithiumhydroxide is an umlsterm, carbon dioxide is an umlsterm, absorption is an umlsterm	DerAnaesthesist.00490106.eng.abstr_task1	Sentence: Abstract Aim of the study was the clinical investigation of sevoflurane degradation when using water-free lithiumhydroxide versus moist Draegersorb 800 for carbon dioxide absorption . Instructions: please typing these entity words according to sentence: Abstract, clinical investigation, sevoflurane, degradation, lithiumhydroxide, carbon dioxide, absorption Options: umlsterm	[ "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O" ]	Abstract Aim of the study was the clinical investigation of sevoflurane degradation when using water-free lithiumhydroxide versus moist Draegersorb 800 for carbon dioxide absorption .	[ "Abstract", "Aim", "of", "the", "study", "was", "the", "clinical", "investigation", "of", "sevoflurane", "degradation", "when", "using", "water", "-", "free", "lithiumhydroxide", "versus", "moist", "Draegersorb", "800", "for", "carbon", "dioxide", "absorption", "." ]	[ "umlsterm" ]
Abstract, clinical investigation, sevoflurane, degradation, lithiumhydroxide, carbon dioxide, absorption	DerAnaesthesist.00490106.eng.abstr_task2	Sentence: Abstract Aim of the study was the clinical investigation of sevoflurane degradation when using water-free lithiumhydroxide versus moist Draegersorb 800 for carbon dioxide absorption . Instructions: please extract entity words from the input sentence	[ "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O" ]	Abstract Aim of the study was the clinical investigation of sevoflurane degradation when using water-free lithiumhydroxide versus moist Draegersorb 800 for carbon dioxide absorption .	[ "Abstract", "Aim", "of", "the", "study", "was", "the", "clinical", "investigation", "of", "sevoflurane", "degradation", "when", "using", "water", "-", "free", "lithiumhydroxide", "versus", "moist", "Draegersorb", "800", "for", "carbon", "dioxide", "absorption", "." ]	[ "umlsterm" ]
K - ras is a Protein, K - ras is a Protein, K - ras is a Protein, K - ras is a Protein, K - ras is a Protein	531_task0	Sentence: Beta 1-6 branching of N-linked carbohydrate is associated with K-ras mutation in human colon carcinoma cell lines. Here the K-ras genotypes of nine colon carcinoma cell lines are compared to the protein glycosylation patterns found in these cells. By a variety of methodologies utilizing lectins to probe carbohydrate structure, we find evidence that five out of six cell lines having K-ras mutations have elevated amounts of beta 1-6 branching at the trimannosyl core of N-linked carbohydrate. None of the three K-ras wild type cell lines assayed have evidence of elevated beta 1-6 branching. In five out of five cell lines examined, the amount of beta 1-6 branching correlates with the extent of cellular ras-GTP elevation and supports the hypothesis that expression of beta 1-6 branching in colon carcinoma cell lines is quantitatively linked to K-ras activation. These results are discussed in the context of the ras-signalling pathway. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Beta 1-6 branching of N-linked carbohydrate is associated with K-ras mutation in human colon carcinoma cell lines. Here the K-ras genotypes of nine colon carcinoma cell lines are compared to the protein glycosylation patterns found in these cells. By a variety of methodologies utilizing lectins to probe carbohydrate structure, we find evidence that five out of six cell lines having K-ras mutations have elevated amounts of beta 1-6 branching at the trimannosyl core of N-linked carbohydrate. None of the three K-ras wild type cell lines assayed have evidence of elevated beta 1-6 branching. In five out of five cell lines examined, the amount of beta 1-6 branching correlates with the extent of cellular ras-GTP elevation and supports the hypothesis that expression of beta 1-6 branching in colon carcinoma cell lines is quantitatively linked to K-ras activation. These results are discussed in the context of the ras-signalling pathway.	[ "Beta", "1", "-", "6", "branching", "of", "N", "-", "linked", "carbohydrate", "is", "associated", "with", "K", "-", "ras", "mutation", "in", "human", "colon", "carcinoma", "cell", "lines", ".", "\n", "Here", "the", "K", "-", "ras", "genotypes", "of", "nine", "colon", "carcinoma", "cell", "lines", "are", "compared", "to", "the", "protein", "glycosylation", "patterns", "found", "in", "these", "cells", ".", "By", "a", "variety", "of", "methodologies", "utilizing", "lectins", "to", "probe", "carbohydrate", "structure", ",", "we", "find", "evidence", "that", "five", "out", "of", "six", "cell", "lines", "having", "K", "-", "ras", "mutations", "have", "elevated", "amounts", "of", "beta", "1", "-", "6", "branching", "at", "the", "trimannosyl", "core", "of", "N", "-", "linked", "carbohydrate", ".", "None", "of", "the", "three", "K", "-", "ras", "wild", "type", "cell", "lines", "assayed", "have", "evidence", "of", "elevated", "beta", "1", "-", "6", "branching", ".", "In", "five", "out", "of", "five", "cell", "lines", "examined", ",", "the", "amount", "of", "beta", "1", "-", "6", "branching", "correlates", "with", "the", "extent", "of", "cellular", "ras", "-", "GTP", "elevation", "and", "supports", "the", "hypothesis", "that", "expression", "of", "beta", "1", "-", "6", "branching", "in", "colon", "carcinoma", "cell", "lines", "is", "quantitatively", "linked", "to", "K", "-", "ras", "activation", ".", "These", "results", "are", "discussed", "in", "the", "context", "of", "the", "ras", "-", "signalling", "pathway", ".", "\n" ]	[ "Protein" ]
K - ras is a Protein, K - ras is a Protein, K - ras is a Protein, K - ras is a Protein, K - ras is a Protein	531_task1	Sentence: Beta 1-6 branching of N-linked carbohydrate is associated with K-ras mutation in human colon carcinoma cell lines. Here the K-ras genotypes of nine colon carcinoma cell lines are compared to the protein glycosylation patterns found in these cells. By a variety of methodologies utilizing lectins to probe carbohydrate structure, we find evidence that five out of six cell lines having K-ras mutations have elevated amounts of beta 1-6 branching at the trimannosyl core of N-linked carbohydrate. None of the three K-ras wild type cell lines assayed have evidence of elevated beta 1-6 branching. In five out of five cell lines examined, the amount of beta 1-6 branching correlates with the extent of cellular ras-GTP elevation and supports the hypothesis that expression of beta 1-6 branching in colon carcinoma cell lines is quantitatively linked to K-ras activation. These results are discussed in the context of the ras-signalling pathway. Instructions: please typing these entity words according to sentence: K - ras, K - ras, K - ras, K - ras, K - ras Options: Protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Beta 1-6 branching of N-linked carbohydrate is associated with K-ras mutation in human colon carcinoma cell lines. Here the K-ras genotypes of nine colon carcinoma cell lines are compared to the protein glycosylation patterns found in these cells. By a variety of methodologies utilizing lectins to probe carbohydrate structure, we find evidence that five out of six cell lines having K-ras mutations have elevated amounts of beta 1-6 branching at the trimannosyl core of N-linked carbohydrate. None of the three K-ras wild type cell lines assayed have evidence of elevated beta 1-6 branching. In five out of five cell lines examined, the amount of beta 1-6 branching correlates with the extent of cellular ras-GTP elevation and supports the hypothesis that expression of beta 1-6 branching in colon carcinoma cell lines is quantitatively linked to K-ras activation. These results are discussed in the context of the ras-signalling pathway.	[ "Beta", "1", "-", "6", "branching", "of", "N", "-", "linked", "carbohydrate", "is", "associated", "with", "K", "-", "ras", "mutation", "in", "human", "colon", "carcinoma", "cell", "lines", ".", "\n", "Here", "the", "K", "-", "ras", "genotypes", "of", "nine", "colon", "carcinoma", "cell", "lines", "are", "compared", "to", "the", "protein", "glycosylation", "patterns", "found", "in", "these", "cells", ".", "By", "a", "variety", "of", "methodologies", "utilizing", "lectins", "to", "probe", "carbohydrate", "structure", ",", "we", "find", "evidence", "that", "five", "out", "of", "six", "cell", "lines", "having", "K", "-", "ras", "mutations", "have", "elevated", "amounts", "of", "beta", "1", "-", "6", "branching", "at", "the", "trimannosyl", "core", "of", "N", "-", "linked", "carbohydrate", ".", "None", "of", "the", "three", "K", "-", "ras", "wild", "type", "cell", "lines", "assayed", "have", "evidence", "of", "elevated", "beta", "1", "-", "6", "branching", ".", "In", "five", "out", "of", "five", "cell", "lines", "examined", ",", "the", "amount", "of", "beta", "1", "-", "6", "branching", "correlates", "with", "the", "extent", "of", "cellular", "ras", "-", "GTP", "elevation", "and", "supports", "the", "hypothesis", "that", "expression", "of", "beta", "1", "-", "6", "branching", "in", "colon", "carcinoma", "cell", "lines", "is", "quantitatively", "linked", "to", "K", "-", "ras", "activation", ".", "These", "results", "are", "discussed", "in", "the", "context", "of", "the", "ras", "-", "signalling", "pathway", ".", "\n" ]	[ "Protein" ]
K - ras, K - ras, K - ras, K - ras, K - ras	531_task2	Sentence: Beta 1-6 branching of N-linked carbohydrate is associated with K-ras mutation in human colon carcinoma cell lines. Here the K-ras genotypes of nine colon carcinoma cell lines are compared to the protein glycosylation patterns found in these cells. By a variety of methodologies utilizing lectins to probe carbohydrate structure, we find evidence that five out of six cell lines having K-ras mutations have elevated amounts of beta 1-6 branching at the trimannosyl core of N-linked carbohydrate. None of the three K-ras wild type cell lines assayed have evidence of elevated beta 1-6 branching. In five out of five cell lines examined, the amount of beta 1-6 branching correlates with the extent of cellular ras-GTP elevation and supports the hypothesis that expression of beta 1-6 branching in colon carcinoma cell lines is quantitatively linked to K-ras activation. These results are discussed in the context of the ras-signalling pathway. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Beta 1-6 branching of N-linked carbohydrate is associated with K-ras mutation in human colon carcinoma cell lines. Here the K-ras genotypes of nine colon carcinoma cell lines are compared to the protein glycosylation patterns found in these cells. By a variety of methodologies utilizing lectins to probe carbohydrate structure, we find evidence that five out of six cell lines having K-ras mutations have elevated amounts of beta 1-6 branching at the trimannosyl core of N-linked carbohydrate. None of the three K-ras wild type cell lines assayed have evidence of elevated beta 1-6 branching. In five out of five cell lines examined, the amount of beta 1-6 branching correlates with the extent of cellular ras-GTP elevation and supports the hypothesis that expression of beta 1-6 branching in colon carcinoma cell lines is quantitatively linked to K-ras activation. These results are discussed in the context of the ras-signalling pathway.	[ "Beta", "1", "-", "6", "branching", "of", "N", "-", "linked", "carbohydrate", "is", "associated", "with", "K", "-", "ras", "mutation", "in", "human", "colon", "carcinoma", "cell", "lines", ".", "\n", "Here", "the", "K", "-", "ras", "genotypes", "of", "nine", "colon", "carcinoma", "cell", "lines", "are", "compared", "to", "the", "protein", "glycosylation", "patterns", "found", "in", "these", "cells", ".", "By", "a", "variety", "of", "methodologies", "utilizing", "lectins", "to", "probe", "carbohydrate", "structure", ",", "we", "find", "evidence", "that", "five", "out", "of", "six", "cell", "lines", "having", "K", "-", "ras", "mutations", "have", "elevated", "amounts", "of", "beta", "1", "-", "6", "branching", "at", "the", "trimannosyl", "core", "of", "N", "-", "linked", "carbohydrate", ".", "None", "of", "the", "three", "K", "-", "ras", "wild", "type", "cell", "lines", "assayed", "have", "evidence", "of", "elevated", "beta", "1", "-", "6", "branching", ".", "In", "five", "out", "of", "five", "cell", "lines", "examined", ",", "the", "amount", "of", "beta", "1", "-", "6", "branching", "correlates", "with", "the", "extent", "of", "cellular", "ras", "-", "GTP", "elevation", "and", "supports", "the", "hypothesis", "that", "expression", "of", "beta", "1", "-", "6", "branching", "in", "colon", "carcinoma", "cell", "lines", "is", "quantitatively", "linked", "to", "K", "-", "ras", "activation", ".", "These", "results", "are", "discussed", "in", "the", "context", "of", "the", "ras", "-", "signalling", "pathway", ".", "\n" ]	[ "Protein" ]
use is an umlsterm, argon - laser is an umlsterm, coagulation is an umlsterm, retinal arteries is an umlsterm	DerOpthalmologe.70940724.eng.abstr_task0	Sentence: By the use of a new online measuring system the effect of argon-laser coagulation in diabetics on the diameters of retinal arteries was measured . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O" ]	By the use of a new online measuring system the effect of argon-laser coagulation in diabetics on the diameters of retinal arteries was measured .	[ "By", "the", "use", "of", "a", "new", "online", "measuring", "system", "the", "effect", "of", "argon", "-", "laser", "coagulation", "in", "diabetics", "on", "the", "diameters", "of", "retinal", "arteries", "was", "measured", "." ]	[ "umlsterm" ]
use is an umlsterm, argon - laser is an umlsterm, coagulation is an umlsterm, retinal arteries is an umlsterm	DerOpthalmologe.70940724.eng.abstr_task1	Sentence: By the use of a new online measuring system the effect of argon-laser coagulation in diabetics on the diameters of retinal arteries was measured . Instructions: please typing these entity words according to sentence: use, argon - laser, coagulation, retinal arteries Options: umlsterm	[ "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O" ]	By the use of a new online measuring system the effect of argon-laser coagulation in diabetics on the diameters of retinal arteries was measured .	[ "By", "the", "use", "of", "a", "new", "online", "measuring", "system", "the", "effect", "of", "argon", "-", "laser", "coagulation", "in", "diabetics", "on", "the", "diameters", "of", "retinal", "arteries", "was", "measured", "." ]	[ "umlsterm" ]
use, argon - laser, coagulation, retinal arteries	DerOpthalmologe.70940724.eng.abstr_task2	Sentence: By the use of a new online measuring system the effect of argon-laser coagulation in diabetics on the diameters of retinal arteries was measured . Instructions: please extract entity words from the input sentence	[ "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O" ]	By the use of a new online measuring system the effect of argon-laser coagulation in diabetics on the diameters of retinal arteries was measured .	[ "By", "the", "use", "of", "a", "new", "online", "measuring", "system", "the", "effect", "of", "argon", "-", "laser", "coagulation", "in", "diabetics", "on", "the", "diameters", "of", "retinal", "arteries", "was", "measured", "." ]	[ "umlsterm" ]
Clonidine is a Intervention_Pharmacological, metabolic control in type 2 diabetic patients is a Outcome_Physical, ophthalmic is a Participant_Condition, clonidine is a Intervention_Pharmacological, blood glucose control is a Outcome_Physical, insulin requirements is a Outcome_Physical, flunitrazepam is a Intervention_Pharmacological, Blood glucose concentrations is a Outcome_Physical, Plasma C - peptide and counter - regulatory hormones is a Outcome_Physical, Glycaemia is a Outcome_Physical, median amount of insulin administered is a Outcome_Physical, Plasma catecholamine concentrations is a Outcome_Physical, cortisol concentrations . is a Outcome_Physical	12502_task0	Sentence: Clonidine premedication improves metabolic control in type 2 diabetic patients during ophthalmic surgery . BACKGROUND In stressful conditions , increasing blood glucose concentrations are closely related to an increase in catecholamines and cortisol release . Clonidine , a centrally acting alpha ( 2 ) -adrenoceptor agonist , has neuroendocrine effects , including inhibition of sympathoadrenal activity . We therefore evaluated the effect of clonidine on blood glucose control and insulin requirements during ophthalmic surgery when given as premedication in type 2 diabetic patients . METHODS After randomization , patients were premedicated with clonidine or flunitrazepam ( control ) . Patients were given insulin by continuous i.v . infusion to maintain blood glucose in the range 5.5-11.1 mmol litre ( -1 ) . Blood glucose concentrations were measured every 15 min during surgery , and hourly for 6 h after surgery . Plasma C-peptide and counter-regulatory hormones were also measured . RESULTS Glycaemia was significantly lower in the clonidine group ( P < 0.01 ) and the median amount of insulin administered was significantly reduced : clonidine group 9.0 ( interquartile range 5.1 ) units ; control 18.6 ( 10.2 ) units ; P < 0.01 ) . Plasma catecholamine concentrations were lower in patients given clonidine ( P < 0.05 ) but there was no difference in cortisol concentrations . CONCLUSION Premedication of type 2 diabetic patients with clonidine 90 min before surgery improves blood glucose control and decreases insulin requirements during ophthalmic surgery . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Outcome_Physical, Participant_Condition	[ "B-Intervention_Pharmacological", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Clonidine premedication improves metabolic control in type 2 diabetic patients during ophthalmic surgery . BACKGROUND In stressful conditions , increasing blood glucose concentrations are closely related to an increase in catecholamines and cortisol release . Clonidine , a centrally acting alpha ( 2 ) -adrenoceptor agonist , has neuroendocrine effects , including inhibition of sympathoadrenal activity . We therefore evaluated the effect of clonidine on blood glucose control and insulin requirements during ophthalmic surgery when given as premedication in type 2 diabetic patients . METHODS After randomization , patients were premedicated with clonidine or flunitrazepam ( control ) . Patients were given insulin by continuous i.v . infusion to maintain blood glucose in the range 5.5-11.1 mmol litre ( -1 ) . Blood glucose concentrations were measured every 15 min during surgery , and hourly for 6 h after surgery . Plasma C-peptide and counter-regulatory hormones were also measured . RESULTS Glycaemia was significantly lower in the clonidine group ( P < 0.01 ) and the median amount of insulin administered was significantly reduced : clonidine group 9.0 ( interquartile range 5.1 ) units ; control 18.6 ( 10.2 ) units ; P < 0.01 ) . Plasma catecholamine concentrations were lower in patients given clonidine ( P < 0.05 ) but there was no difference in cortisol concentrations . CONCLUSION Premedication of type 2 diabetic patients with clonidine 90 min before surgery improves blood glucose control and decreases insulin requirements during ophthalmic surgery .	[ "Clonidine", "premedication", "improves", "metabolic", "control", "in", "type", "2", "diabetic", "patients", "during", "ophthalmic", "surgery", ".", "BACKGROUND", "In", "stressful", "conditions", ",", "increasing", "blood", "glucose", "concentrations", "are", "closely", "related", "to", "an", "increase", "in", "catecholamines", "and", "cortisol", "release", ".", "Clonidine", ",", "a", "centrally", "acting", "alpha", "(", "2", ")", "-adrenoceptor", "agonist", ",", "has", "neuroendocrine", "effects", ",", "including", "inhibition", "of", "sympathoadrenal", "activity", ".", "We", "therefore", "evaluated", "the", "effect", "of", "clonidine", "on", "blood", "glucose", "control", "and", "insulin", "requirements", "during", "ophthalmic", "surgery", "when", "given", "as", "premedication", "in", "type", "2", "diabetic", "patients", ".", "METHODS", "After", "randomization", ",", "patients", "were", "premedicated", "with", "clonidine", "or", "flunitrazepam", "(", "control", ")", ".", "Patients", "were", "given", "insulin", "by", "continuous", "i.v", ".", "infusion", "to", "maintain", "blood", "glucose", "in", "the", "range", "5.5", "-", "11.1", "mmol", "litre", "(", "-1", ")", ".", "Blood", "glucose", "concentrations", "were", "measured", "every", "15", "min", "during", "surgery", ",", "and", "hourly", "for", "6", "h", "after", "surgery", ".", "Plasma", "C", "-", "peptide", "and", "counter", "-", "regulatory", "hormones", "were", "also", "measured", ".", "RESULTS", "Glycaemia", "was", "significantly", "lower", "in", "the", "clonidine", "group", "(", "P", "<", "0.01", ")", "and", "the", "median", "amount", "of", "insulin", "administered", "was", "significantly", "reduced", ":", "clonidine", "group", "9.0", "(", "interquartile", "range", "5.1", ")", "units", ";", "control", "18.6", "(", "10.2", ")", "units", ";", "P", "<", "0.01", ")", ".", "Plasma", "catecholamine", "concentrations", "were", "lower", "in", "patients", "given", "clonidine", "(", "P", "<", "0.05", ")", "but", "there", "was", "no", "difference", "in", "cortisol", "concentrations", ".", "CONCLUSION", "Premedication", "of", "type", "2", "diabetic", "patients", "with", "clonidine", "90", "min", "before", "surgery", "improves", "blood", "glucose", "control", "and", "decreases", "insulin", "requirements", "during", "ophthalmic", "surgery", "." ]	[ "Outcome_Physical", "Participant_Condition", "Intervention_Pharmacological" ]
Clonidine is a Intervention_Pharmacological, metabolic control in type 2 diabetic patients is a Outcome_Physical, ophthalmic is a Participant_Condition, clonidine is a Intervention_Pharmacological, blood glucose control is a Outcome_Physical, insulin requirements is a Outcome_Physical, flunitrazepam is a Intervention_Pharmacological, Blood glucose concentrations is a Outcome_Physical, Plasma C - peptide and counter - regulatory hormones is a Outcome_Physical, Glycaemia is a Outcome_Physical, median amount of insulin administered is a Outcome_Physical, Plasma catecholamine concentrations is a Outcome_Physical, cortisol concentrations . is a Outcome_Physical	12502_task1	Sentence: Clonidine premedication improves metabolic control in type 2 diabetic patients during ophthalmic surgery . BACKGROUND In stressful conditions , increasing blood glucose concentrations are closely related to an increase in catecholamines and cortisol release . Clonidine , a centrally acting alpha ( 2 ) -adrenoceptor agonist , has neuroendocrine effects , including inhibition of sympathoadrenal activity . We therefore evaluated the effect of clonidine on blood glucose control and insulin requirements during ophthalmic surgery when given as premedication in type 2 diabetic patients . METHODS After randomization , patients were premedicated with clonidine or flunitrazepam ( control ) . Patients were given insulin by continuous i.v . infusion to maintain blood glucose in the range 5.5-11.1 mmol litre ( -1 ) . Blood glucose concentrations were measured every 15 min during surgery , and hourly for 6 h after surgery . Plasma C-peptide and counter-regulatory hormones were also measured . RESULTS Glycaemia was significantly lower in the clonidine group ( P < 0.01 ) and the median amount of insulin administered was significantly reduced : clonidine group 9.0 ( interquartile range 5.1 ) units ; control 18.6 ( 10.2 ) units ; P < 0.01 ) . Plasma catecholamine concentrations were lower in patients given clonidine ( P < 0.05 ) but there was no difference in cortisol concentrations . CONCLUSION Premedication of type 2 diabetic patients with clonidine 90 min before surgery improves blood glucose control and decreases insulin requirements during ophthalmic surgery . Instructions: please typing these entity words according to sentence: Clonidine, metabolic control in type 2 diabetic patients, ophthalmic, clonidine, blood glucose control, insulin requirements, flunitrazepam, Blood glucose concentrations, Plasma C - peptide and counter - regulatory hormones, Glycaemia, median amount of insulin administered, Plasma catecholamine concentrations, cortisol concentrations . Options: Intervention_Pharmacological, Outcome_Physical, Participant_Condition	[ "B-Intervention_Pharmacological", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Clonidine premedication improves metabolic control in type 2 diabetic patients during ophthalmic surgery . BACKGROUND In stressful conditions , increasing blood glucose concentrations are closely related to an increase in catecholamines and cortisol release . Clonidine , a centrally acting alpha ( 2 ) -adrenoceptor agonist , has neuroendocrine effects , including inhibition of sympathoadrenal activity . We therefore evaluated the effect of clonidine on blood glucose control and insulin requirements during ophthalmic surgery when given as premedication in type 2 diabetic patients . METHODS After randomization , patients were premedicated with clonidine or flunitrazepam ( control ) . Patients were given insulin by continuous i.v . infusion to maintain blood glucose in the range 5.5-11.1 mmol litre ( -1 ) . Blood glucose concentrations were measured every 15 min during surgery , and hourly for 6 h after surgery . Plasma C-peptide and counter-regulatory hormones were also measured . RESULTS Glycaemia was significantly lower in the clonidine group ( P < 0.01 ) and the median amount of insulin administered was significantly reduced : clonidine group 9.0 ( interquartile range 5.1 ) units ; control 18.6 ( 10.2 ) units ; P < 0.01 ) . Plasma catecholamine concentrations were lower in patients given clonidine ( P < 0.05 ) but there was no difference in cortisol concentrations . CONCLUSION Premedication of type 2 diabetic patients with clonidine 90 min before surgery improves blood glucose control and decreases insulin requirements during ophthalmic surgery .	[ "Clonidine", "premedication", "improves", "metabolic", "control", "in", "type", "2", "diabetic", "patients", "during", "ophthalmic", "surgery", ".", "BACKGROUND", "In", "stressful", "conditions", ",", "increasing", "blood", "glucose", "concentrations", "are", "closely", "related", "to", "an", "increase", "in", "catecholamines", "and", "cortisol", "release", ".", "Clonidine", ",", "a", "centrally", "acting", "alpha", "(", "2", ")", "-adrenoceptor", "agonist", ",", "has", "neuroendocrine", "effects", ",", "including", "inhibition", "of", "sympathoadrenal", "activity", ".", "We", "therefore", "evaluated", "the", "effect", "of", "clonidine", "on", "blood", "glucose", "control", "and", "insulin", "requirements", "during", "ophthalmic", "surgery", "when", "given", "as", "premedication", "in", "type", "2", "diabetic", "patients", ".", "METHODS", "After", "randomization", ",", "patients", "were", "premedicated", "with", "clonidine", "or", "flunitrazepam", "(", "control", ")", ".", "Patients", "were", "given", "insulin", "by", "continuous", "i.v", ".", "infusion", "to", "maintain", "blood", "glucose", "in", "the", "range", "5.5", "-", "11.1", "mmol", "litre", "(", "-1", ")", ".", "Blood", "glucose", "concentrations", "were", "measured", "every", "15", "min", "during", "surgery", ",", "and", "hourly", "for", "6", "h", "after", "surgery", ".", "Plasma", "C", "-", "peptide", "and", "counter", "-", "regulatory", "hormones", "were", "also", "measured", ".", "RESULTS", "Glycaemia", "was", "significantly", "lower", "in", "the", "clonidine", "group", "(", "P", "<", "0.01", ")", "and", "the", "median", "amount", "of", "insulin", "administered", "was", "significantly", "reduced", ":", "clonidine", "group", "9.0", "(", "interquartile", "range", "5.1", ")", "units", ";", "control", "18.6", "(", "10.2", ")", "units", ";", "P", "<", "0.01", ")", ".", "Plasma", "catecholamine", "concentrations", "were", "lower", "in", "patients", "given", "clonidine", "(", "P", "<", "0.05", ")", "but", "there", "was", "no", "difference", "in", "cortisol", "concentrations", ".", "CONCLUSION", "Premedication", "of", "type", "2", "diabetic", "patients", "with", "clonidine", "90", "min", "before", "surgery", "improves", "blood", "glucose", "control", "and", "decreases", "insulin", "requirements", "during", "ophthalmic", "surgery", "." ]	[ "Outcome_Physical", "Participant_Condition", "Intervention_Pharmacological" ]
Clonidine, metabolic control in type 2 diabetic patients, ophthalmic, clonidine, blood glucose control, insulin requirements, flunitrazepam, Blood glucose concentrations, Plasma C - peptide and counter - regulatory hormones, Glycaemia, median amount of insulin administered, Plasma catecholamine concentrations, cortisol concentrations .	12502_task2	Sentence: Clonidine premedication improves metabolic control in type 2 diabetic patients during ophthalmic surgery . BACKGROUND In stressful conditions , increasing blood glucose concentrations are closely related to an increase in catecholamines and cortisol release . Clonidine , a centrally acting alpha ( 2 ) -adrenoceptor agonist , has neuroendocrine effects , including inhibition of sympathoadrenal activity . We therefore evaluated the effect of clonidine on blood glucose control and insulin requirements during ophthalmic surgery when given as premedication in type 2 diabetic patients . METHODS After randomization , patients were premedicated with clonidine or flunitrazepam ( control ) . Patients were given insulin by continuous i.v . infusion to maintain blood glucose in the range 5.5-11.1 mmol litre ( -1 ) . Blood glucose concentrations were measured every 15 min during surgery , and hourly for 6 h after surgery . Plasma C-peptide and counter-regulatory hormones were also measured . RESULTS Glycaemia was significantly lower in the clonidine group ( P < 0.01 ) and the median amount of insulin administered was significantly reduced : clonidine group 9.0 ( interquartile range 5.1 ) units ; control 18.6 ( 10.2 ) units ; P < 0.01 ) . Plasma catecholamine concentrations were lower in patients given clonidine ( P < 0.05 ) but there was no difference in cortisol concentrations . CONCLUSION Premedication of type 2 diabetic patients with clonidine 90 min before surgery improves blood glucose control and decreases insulin requirements during ophthalmic surgery . Instructions: please extract entity words from the input sentence	[ "B-Intervention_Pharmacological", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Clonidine premedication improves metabolic control in type 2 diabetic patients during ophthalmic surgery . BACKGROUND In stressful conditions , increasing blood glucose concentrations are closely related to an increase in catecholamines and cortisol release . Clonidine , a centrally acting alpha ( 2 ) -adrenoceptor agonist , has neuroendocrine effects , including inhibition of sympathoadrenal activity . We therefore evaluated the effect of clonidine on blood glucose control and insulin requirements during ophthalmic surgery when given as premedication in type 2 diabetic patients . METHODS After randomization , patients were premedicated with clonidine or flunitrazepam ( control ) . Patients were given insulin by continuous i.v . infusion to maintain blood glucose in the range 5.5-11.1 mmol litre ( -1 ) . Blood glucose concentrations were measured every 15 min during surgery , and hourly for 6 h after surgery . Plasma C-peptide and counter-regulatory hormones were also measured . RESULTS Glycaemia was significantly lower in the clonidine group ( P < 0.01 ) and the median amount of insulin administered was significantly reduced : clonidine group 9.0 ( interquartile range 5.1 ) units ; control 18.6 ( 10.2 ) units ; P < 0.01 ) . Plasma catecholamine concentrations were lower in patients given clonidine ( P < 0.05 ) but there was no difference in cortisol concentrations . CONCLUSION Premedication of type 2 diabetic patients with clonidine 90 min before surgery improves blood glucose control and decreases insulin requirements during ophthalmic surgery .	[ "Clonidine", "premedication", "improves", "metabolic", "control", "in", "type", "2", "diabetic", "patients", "during", "ophthalmic", "surgery", ".", "BACKGROUND", "In", "stressful", "conditions", ",", "increasing", "blood", "glucose", "concentrations", "are", "closely", "related", "to", "an", "increase", "in", "catecholamines", "and", "cortisol", "release", ".", "Clonidine", ",", "a", "centrally", "acting", "alpha", "(", "2", ")", "-adrenoceptor", "agonist", ",", "has", "neuroendocrine", "effects", ",", "including", "inhibition", "of", "sympathoadrenal", "activity", ".", "We", "therefore", "evaluated", "the", "effect", "of", "clonidine", "on", "blood", "glucose", "control", "and", "insulin", "requirements", "during", "ophthalmic", "surgery", "when", "given", "as", "premedication", "in", "type", "2", "diabetic", "patients", ".", "METHODS", "After", "randomization", ",", "patients", "were", "premedicated", "with", "clonidine", "or", "flunitrazepam", "(", "control", ")", ".", "Patients", "were", "given", "insulin", "by", "continuous", "i.v", ".", "infusion", "to", "maintain", "blood", "glucose", "in", "the", "range", "5.5", "-", "11.1", "mmol", "litre", "(", "-1", ")", ".", "Blood", "glucose", "concentrations", "were", "measured", "every", "15", "min", "during", "surgery", ",", "and", "hourly", "for", "6", "h", "after", "surgery", ".", "Plasma", "C", "-", "peptide", "and", "counter", "-", "regulatory", "hormones", "were", "also", "measured", ".", "RESULTS", "Glycaemia", "was", "significantly", "lower", "in", "the", "clonidine", "group", "(", "P", "<", "0.01", ")", "and", "the", "median", "amount", "of", "insulin", "administered", "was", "significantly", "reduced", ":", "clonidine", "group", "9.0", "(", "interquartile", "range", "5.1", ")", "units", ";", "control", "18.6", "(", "10.2", ")", "units", ";", "P", "<", "0.01", ")", ".", "Plasma", "catecholamine", "concentrations", "were", "lower", "in", "patients", "given", "clonidine", "(", "P", "<", "0.05", ")", "but", "there", "was", "no", "difference", "in", "cortisol", "concentrations", ".", "CONCLUSION", "Premedication", "of", "type", "2", "diabetic", "patients", "with", "clonidine", "90", "min", "before", "surgery", "improves", "blood", "glucose", "control", "and", "decreases", "insulin", "requirements", "during", "ophthalmic", "surgery", "." ]	[ "Outcome_Physical", "Participant_Condition", "Intervention_Pharmacological" ]
Hydatid disease is an umlsterm, parasitic is an umlsterm, tapeworm is an umlsterm, Echinococcus is an umlsterm, stage is an umlsterm, parasite is an umlsterm, liver is an umlsterm, bone is an umlsterm, accounting is an umlsterm, hip joint is an umlsterm, os pubis is an umlsterm, ileum is an umlsterm, femoral head is an umlsterm, Recurrence is an umlsterm, hydatid cyst is an umlsterm, groin is an umlsterm, femur is an umlsterm, total hip replacement is an umlsterm, polyacetal is an umlsterm, device is an umlsterm, aid is an umlsterm, CAD is an umlsterm, techniques is an umlsterm, surgical procedure is an umlsterm, chemotherapy is an umlsterm, mebendazole is an umlsterm, hydatid disease is an umlsterm	DerChirurg.70680832.eng.abstr_task0	Sentence: Hydatid disease is caused by the parasitic tapeworm Echinococcus . The larval stage of this parasite can thrive in many parts of the body , most frequently in the liver . Primary bone location is very rare , accounting for less than 2 % of all hydatid lesions . We report on a case of left-sided extended pelvic infestation . The destruction of the hip joint , os pubis , large parts of the ileum and the femoral head made pelvic resection and prosthetic replacement necessary . Recurrence of a hydatid cyst 5 years later in the left groin originating from the proximal femur was treated with second femoral resection and new total hip replacement . Because of instability , the primarily inserted polyacetal pelvic replacement had to be exchanged for a custom-made device fabricated with the aid of computer-aided design ( CAD ) techniques . This surgical procedure was combined with chemotherapy ( mebendazole ) . The necessity of radical resection in osseus hydatid disease is discussed . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O" ]	Hydatid disease is caused by the parasitic tapeworm Echinococcus . The larval stage of this parasite can thrive in many parts of the body , most frequently in the liver . Primary bone location is very rare , accounting for less than 2 % of all hydatid lesions . We report on a case of left-sided extended pelvic infestation . The destruction of the hip joint , os pubis , large parts of the ileum and the femoral head made pelvic resection and prosthetic replacement necessary . Recurrence of a hydatid cyst 5 years later in the left groin originating from the proximal femur was treated with second femoral resection and new total hip replacement . Because of instability , the primarily inserted polyacetal pelvic replacement had to be exchanged for a custom-made device fabricated with the aid of computer-aided design ( CAD ) techniques . This surgical procedure was combined with chemotherapy ( mebendazole ) . The necessity of radical resection in osseus hydatid disease is discussed .	[ "Hydatid", "disease", "is", "caused", "by", "the", "parasitic", "tapeworm", "Echinococcus", ".", "The", "larval", "stage", "of", "this", "parasite", "can", "thrive", "in", "many", "parts", "of", "the", "body", ",", "most", "frequently", "in", "the", "liver", ".", "Primary", "bone", "location", "is", "very", "rare", ",", "accounting", "for", "less", "than", "2", "%", "of", "all", "hydatid", "lesions", ".", "We", "report", "on", "a", "case", "of", "left", "-", "sided", "extended", "pelvic", "infestation", ".", "The", "destruction", "of", "the", "hip", "joint", ",", "os", "pubis", ",", "large", "parts", "of", "the", "ileum", "and", "the", "femoral", "head", "made", "pelvic", "resection", "and", "prosthetic", "replacement", "necessary", ".", "Recurrence", "of", "a", "hydatid", "cyst", "5", "years", "later", "in", "the", "left", "groin", "originating", "from", "the", "proximal", "femur", "was", "treated", "with", "second", "femoral", "resection", "and", "new", "total", "hip", "replacement", ".", "Because", "of", "instability", ",", "the", "primarily", "inserted", "polyacetal", "pelvic", "replacement", "had", "to", "be", "exchanged", "for", "a", "custom", "-", "made", "device", "fabricated", "with", "the", "aid", "of", "computer", "-", "aided", "design", "(", "CAD", ")", "techniques", ".", "This", "surgical", "procedure", "was", "combined", "with", "chemotherapy", "(", "mebendazole", ")", ".", "The", "necessity", "of", "radical", "resection", "in", "osseus", "hydatid", "disease", "is", "discussed", "." ]	[ "umlsterm" ]
Hydatid disease is an umlsterm, parasitic is an umlsterm, tapeworm is an umlsterm, Echinococcus is an umlsterm, stage is an umlsterm, parasite is an umlsterm, liver is an umlsterm, bone is an umlsterm, accounting is an umlsterm, hip joint is an umlsterm, os pubis is an umlsterm, ileum is an umlsterm, femoral head is an umlsterm, Recurrence is an umlsterm, hydatid cyst is an umlsterm, groin is an umlsterm, femur is an umlsterm, total hip replacement is an umlsterm, polyacetal is an umlsterm, device is an umlsterm, aid is an umlsterm, CAD is an umlsterm, techniques is an umlsterm, surgical procedure is an umlsterm, chemotherapy is an umlsterm, mebendazole is an umlsterm, hydatid disease is an umlsterm	DerChirurg.70680832.eng.abstr_task1	Sentence: Hydatid disease is caused by the parasitic tapeworm Echinococcus . The larval stage of this parasite can thrive in many parts of the body , most frequently in the liver . Primary bone location is very rare , accounting for less than 2 % of all hydatid lesions . We report on a case of left-sided extended pelvic infestation . The destruction of the hip joint , os pubis , large parts of the ileum and the femoral head made pelvic resection and prosthetic replacement necessary . Recurrence of a hydatid cyst 5 years later in the left groin originating from the proximal femur was treated with second femoral resection and new total hip replacement . Because of instability , the primarily inserted polyacetal pelvic replacement had to be exchanged for a custom-made device fabricated with the aid of computer-aided design ( CAD ) techniques . This surgical procedure was combined with chemotherapy ( mebendazole ) . The necessity of radical resection in osseus hydatid disease is discussed . Instructions: please typing these entity words according to sentence: Hydatid disease, parasitic, tapeworm, Echinococcus, stage, parasite, liver, bone, accounting, hip joint, os pubis, ileum, femoral head, Recurrence, hydatid cyst, groin, femur, total hip replacement, polyacetal, device, aid, CAD, techniques, surgical procedure, chemotherapy, mebendazole, hydatid disease Options: umlsterm	[ "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O" ]	Hydatid disease is caused by the parasitic tapeworm Echinococcus . The larval stage of this parasite can thrive in many parts of the body , most frequently in the liver . Primary bone location is very rare , accounting for less than 2 % of all hydatid lesions . We report on a case of left-sided extended pelvic infestation . The destruction of the hip joint , os pubis , large parts of the ileum and the femoral head made pelvic resection and prosthetic replacement necessary . Recurrence of a hydatid cyst 5 years later in the left groin originating from the proximal femur was treated with second femoral resection and new total hip replacement . Because of instability , the primarily inserted polyacetal pelvic replacement had to be exchanged for a custom-made device fabricated with the aid of computer-aided design ( CAD ) techniques . This surgical procedure was combined with chemotherapy ( mebendazole ) . The necessity of radical resection in osseus hydatid disease is discussed .	[ "Hydatid", "disease", "is", "caused", "by", "the", "parasitic", "tapeworm", "Echinococcus", ".", "The", "larval", "stage", "of", "this", "parasite", "can", "thrive", "in", "many", "parts", "of", "the", "body", ",", "most", "frequently", "in", "the", "liver", ".", "Primary", "bone", "location", "is", "very", "rare", ",", "accounting", "for", "less", "than", "2", "%", "of", "all", "hydatid", "lesions", ".", "We", "report", "on", "a", "case", "of", "left", "-", "sided", "extended", "pelvic", "infestation", ".", "The", "destruction", "of", "the", "hip", "joint", ",", "os", "pubis", ",", "large", "parts", "of", "the", "ileum", "and", "the", "femoral", "head", "made", "pelvic", "resection", "and", "prosthetic", "replacement", "necessary", ".", "Recurrence", "of", "a", "hydatid", "cyst", "5", "years", "later", "in", "the", "left", "groin", "originating", "from", "the", "proximal", "femur", "was", "treated", "with", "second", "femoral", "resection", "and", "new", "total", "hip", "replacement", ".", "Because", "of", "instability", ",", "the", "primarily", "inserted", "polyacetal", "pelvic", "replacement", "had", "to", "be", "exchanged", "for", "a", "custom", "-", "made", "device", "fabricated", "with", "the", "aid", "of", "computer", "-", "aided", "design", "(", "CAD", ")", "techniques", ".", "This", "surgical", "procedure", "was", "combined", "with", "chemotherapy", "(", "mebendazole", ")", ".", "The", "necessity", "of", "radical", "resection", "in", "osseus", "hydatid", "disease", "is", "discussed", "." ]	[ "umlsterm" ]
Hydatid disease, parasitic, tapeworm, Echinococcus, stage, parasite, liver, bone, accounting, hip joint, os pubis, ileum, femoral head, Recurrence, hydatid cyst, groin, femur, total hip replacement, polyacetal, device, aid, CAD, techniques, surgical procedure, chemotherapy, mebendazole, hydatid disease	DerChirurg.70680832.eng.abstr_task2	Sentence: Hydatid disease is caused by the parasitic tapeworm Echinococcus . The larval stage of this parasite can thrive in many parts of the body , most frequently in the liver . Primary bone location is very rare , accounting for less than 2 % of all hydatid lesions . We report on a case of left-sided extended pelvic infestation . The destruction of the hip joint , os pubis , large parts of the ileum and the femoral head made pelvic resection and prosthetic replacement necessary . Recurrence of a hydatid cyst 5 years later in the left groin originating from the proximal femur was treated with second femoral resection and new total hip replacement . Because of instability , the primarily inserted polyacetal pelvic replacement had to be exchanged for a custom-made device fabricated with the aid of computer-aided design ( CAD ) techniques . This surgical procedure was combined with chemotherapy ( mebendazole ) . The necessity of radical resection in osseus hydatid disease is discussed . Instructions: please extract entity words from the input sentence	[ "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O" ]	Hydatid disease is caused by the parasitic tapeworm Echinococcus . The larval stage of this parasite can thrive in many parts of the body , most frequently in the liver . Primary bone location is very rare , accounting for less than 2 % of all hydatid lesions . We report on a case of left-sided extended pelvic infestation . The destruction of the hip joint , os pubis , large parts of the ileum and the femoral head made pelvic resection and prosthetic replacement necessary . Recurrence of a hydatid cyst 5 years later in the left groin originating from the proximal femur was treated with second femoral resection and new total hip replacement . Because of instability , the primarily inserted polyacetal pelvic replacement had to be exchanged for a custom-made device fabricated with the aid of computer-aided design ( CAD ) techniques . This surgical procedure was combined with chemotherapy ( mebendazole ) . The necessity of radical resection in osseus hydatid disease is discussed .	[ "Hydatid", "disease", "is", "caused", "by", "the", "parasitic", "tapeworm", "Echinococcus", ".", "The", "larval", "stage", "of", "this", "parasite", "can", "thrive", "in", "many", "parts", "of", "the", "body", ",", "most", "frequently", "in", "the", "liver", ".", "Primary", "bone", "location", "is", "very", "rare", ",", "accounting", "for", "less", "than", "2", "%", "of", "all", "hydatid", "lesions", ".", "We", "report", "on", "a", "case", "of", "left", "-", "sided", "extended", "pelvic", "infestation", ".", "The", "destruction", "of", "the", "hip", "joint", ",", "os", "pubis", ",", "large", "parts", "of", "the", "ileum", "and", "the", "femoral", "head", "made", "pelvic", "resection", "and", "prosthetic", "replacement", "necessary", ".", "Recurrence", "of", "a", "hydatid", "cyst", "5", "years", "later", "in", "the", "left", "groin", "originating", "from", "the", "proximal", "femur", "was", "treated", "with", "second", "femoral", "resection", "and", "new", "total", "hip", "replacement", ".", "Because", "of", "instability", ",", "the", "primarily", "inserted", "polyacetal", "pelvic", "replacement", "had", "to", "be", "exchanged", "for", "a", "custom", "-", "made", "device", "fabricated", "with", "the", "aid", "of", "computer", "-", "aided", "design", "(", "CAD", ")", "techniques", ".", "This", "surgical", "procedure", "was", "combined", "with", "chemotherapy", "(", "mebendazole", ")", ".", "The", "necessity", "of", "radical", "resection", "in", "osseus", "hydatid", "disease", "is", "discussed", "." ]	[ "umlsterm" ]
knowledge is an umlsterm, physiology is an umlsterm, pathophysiology is an umlsterm, male is an umlsterm, erectile dysfunction is an umlsterm, etiology - based is an umlsterm, therapies is an umlsterm, period is an umlsterm, behavior is an umlsterm, hand is an umlsterm, life - span is an umlsterm, resources is an umlsterm, therapies is an umlsterm, Sexology is an umlsterm, men is an umlsterm, interdisciplinary research is an umlsterm, therapeutic is an umlsterm, patients is an umlsterm, recognition is an umlsterm, treatment is an umlsterm, sildenafil is an umlsterm, sexual counseling is an umlsterm, therapy is an umlsterm, elderly is an umlsterm, patients is an umlsterm, sexology is an umlsterm, male is an umlsterm, behavior is an umlsterm, self - understanding is an umlsterm, senescence is an umlsterm, sexual dysfunction is an umlsterm, therapeutic is an umlsterm, plans is an umlsterm, behaviour- is an umlsterm, counseling is an umlsterm	Reproduktionsmedizin.90150133.eng.abstr_task0	Sentence: During the past 15 years urologists have acquired a widespread knowledge on physiology and pathophysiology of male erectile dysfunction and consequent etiology-based therapies . The same period was characterized by a profound change of sexual behavior and public appearance of sexual issues . On the other hand the socio-demographic effects of prolonged life-span and reduced socio-economic resources for reimbursement of medical therapies become visible . Sexology of aging men is an interdisciplinary research field ; its scientific results should be included into therapeutic decisions in impotent patients . Especially in recognition of our new treatment options such as oral sildenafil , a partner- and libido-oriented sexual counseling should accompany somatic therapy in most of our elderly patients . There exists no general " sexology of the aging male " but rather an individual sexual behavior and self-understanding that is transported into senescence . " Zeitgeist " -phenomena , partner problems and age-dependent physiologic changes can coincide and potentiate the resulting sexual dysfunction . Modern therapeutic plans should recognize these facts and create behaviour- and partner-oriented counseling strategies combined with minimally invasive somatic approaches . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O" ]	During the past 15 years urologists have acquired a widespread knowledge on physiology and pathophysiology of male erectile dysfunction and consequent etiology-based therapies . The same period was characterized by a profound change of sexual behavior and public appearance of sexual issues . On the other hand the socio-demographic effects of prolonged life-span and reduced socio-economic resources for reimbursement of medical therapies become visible . Sexology of aging men is an interdisciplinary research field ; its scientific results should be included into therapeutic decisions in impotent patients . Especially in recognition of our new treatment options such as oral sildenafil , a partner- and libido-oriented sexual counseling should accompany somatic therapy in most of our elderly patients . There exists no general " sexology of the aging male " but rather an individual sexual behavior and self-understanding that is transported into senescence . " Zeitgeist " -phenomena , partner problems and age-dependent physiologic changes can coincide and potentiate the resulting sexual dysfunction . Modern therapeutic plans should recognize these facts and create behaviour- and partner-oriented counseling strategies combined with minimally invasive somatic approaches .	[ "During", "the", "past", "15", "years", "urologists", "have", "acquired", "a", "widespread", "knowledge", "on", "physiology", "and", "pathophysiology", "of", "male", "erectile", "dysfunction", "and", "consequent", "etiology", "-", "based", "therapies", ".", "The", "same", "period", "was", "characterized", "by", "a", "profound", "change", "of", "sexual", "behavior", "and", "public", "appearance", "of", "sexual", "issues", ".", "On", "the", "other", "hand", "the", "socio", "-", "demographic", "effects", "of", "prolonged", "life", "-", "span", "and", "reduced", "socio", "-", "economic", "resources", "for", "reimbursement", "of", "medical", "therapies", "become", "visible", ".", "Sexology", "of", "aging", "men", "is", "an", "interdisciplinary", "research", "field", ";", "its", "scientific", "results", "should", "be", "included", "into", "therapeutic", "decisions", "in", "impotent", "patients", ".", "Especially", "in", "recognition", "of", "our", "new", "treatment", "options", "such", "as", "oral", "sildenafil", ",", "a", "partner-", "and", "libido", "-", "oriented", "sexual", "counseling", "should", "accompany", "somatic", "therapy", "in", "most", "of", "our", "elderly", "patients", ".", "There", "exists", "no", "general", "\"", "sexology", "of", "the", "aging", "male", "\"", "but", "rather", "an", "individual", "sexual", "behavior", "and", "self", "-", "understanding", "that", "is", "transported", "into", "senescence", ".", "\"", "Zeitgeist", "\"", "-phenomena", ",", "partner", "problems", "and", "age", "-", "dependent", "physiologic", "changes", "can", "coincide", "and", "potentiate", "the", "resulting", "sexual", "dysfunction", ".", "Modern", "therapeutic", "plans", "should", "recognize", "these", "facts", "and", "create", "behaviour-", "and", "partner", "-", "oriented", "counseling", "strategies", "combined", "with", "minimally", "invasive", "somatic", "approaches", "." ]	[ "umlsterm" ]
knowledge is an umlsterm, physiology is an umlsterm, pathophysiology is an umlsterm, male is an umlsterm, erectile dysfunction is an umlsterm, etiology - based is an umlsterm, therapies is an umlsterm, period is an umlsterm, behavior is an umlsterm, hand is an umlsterm, life - span is an umlsterm, resources is an umlsterm, therapies is an umlsterm, Sexology is an umlsterm, men is an umlsterm, interdisciplinary research is an umlsterm, therapeutic is an umlsterm, patients is an umlsterm, recognition is an umlsterm, treatment is an umlsterm, sildenafil is an umlsterm, sexual counseling is an umlsterm, therapy is an umlsterm, elderly is an umlsterm, patients is an umlsterm, sexology is an umlsterm, male is an umlsterm, behavior is an umlsterm, self - understanding is an umlsterm, senescence is an umlsterm, sexual dysfunction is an umlsterm, therapeutic is an umlsterm, plans is an umlsterm, behaviour- is an umlsterm, counseling is an umlsterm	Reproduktionsmedizin.90150133.eng.abstr_task1	Sentence: During the past 15 years urologists have acquired a widespread knowledge on physiology and pathophysiology of male erectile dysfunction and consequent etiology-based therapies . The same period was characterized by a profound change of sexual behavior and public appearance of sexual issues . On the other hand the socio-demographic effects of prolonged life-span and reduced socio-economic resources for reimbursement of medical therapies become visible . Sexology of aging men is an interdisciplinary research field ; its scientific results should be included into therapeutic decisions in impotent patients . Especially in recognition of our new treatment options such as oral sildenafil , a partner- and libido-oriented sexual counseling should accompany somatic therapy in most of our elderly patients . There exists no general " sexology of the aging male " but rather an individual sexual behavior and self-understanding that is transported into senescence . " Zeitgeist " -phenomena , partner problems and age-dependent physiologic changes can coincide and potentiate the resulting sexual dysfunction . Modern therapeutic plans should recognize these facts and create behaviour- and partner-oriented counseling strategies combined with minimally invasive somatic approaches . Instructions: please typing these entity words according to sentence: knowledge, physiology, pathophysiology, male, erectile dysfunction, etiology - based, therapies, period, behavior, hand, life - span, resources, therapies, Sexology, men, interdisciplinary research, therapeutic, patients, recognition, treatment, sildenafil, sexual counseling, therapy, elderly, patients, sexology, male, behavior, self - understanding, senescence, sexual dysfunction, therapeutic, plans, behaviour-, counseling Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O" ]	During the past 15 years urologists have acquired a widespread knowledge on physiology and pathophysiology of male erectile dysfunction and consequent etiology-based therapies . The same period was characterized by a profound change of sexual behavior and public appearance of sexual issues . On the other hand the socio-demographic effects of prolonged life-span and reduced socio-economic resources for reimbursement of medical therapies become visible . Sexology of aging men is an interdisciplinary research field ; its scientific results should be included into therapeutic decisions in impotent patients . Especially in recognition of our new treatment options such as oral sildenafil , a partner- and libido-oriented sexual counseling should accompany somatic therapy in most of our elderly patients . There exists no general " sexology of the aging male " but rather an individual sexual behavior and self-understanding that is transported into senescence . " Zeitgeist " -phenomena , partner problems and age-dependent physiologic changes can coincide and potentiate the resulting sexual dysfunction . Modern therapeutic plans should recognize these facts and create behaviour- and partner-oriented counseling strategies combined with minimally invasive somatic approaches .	[ "During", "the", "past", "15", "years", "urologists", "have", "acquired", "a", "widespread", "knowledge", "on", "physiology", "and", "pathophysiology", "of", "male", "erectile", "dysfunction", "and", "consequent", "etiology", "-", "based", "therapies", ".", "The", "same", "period", "was", "characterized", "by", "a", "profound", "change", "of", "sexual", "behavior", "and", "public", "appearance", "of", "sexual", "issues", ".", "On", "the", "other", "hand", "the", "socio", "-", "demographic", "effects", "of", "prolonged", "life", "-", "span", "and", "reduced", "socio", "-", "economic", "resources", "for", "reimbursement", "of", "medical", "therapies", "become", "visible", ".", "Sexology", "of", "aging", "men", "is", "an", "interdisciplinary", "research", "field", ";", "its", "scientific", "results", "should", "be", "included", "into", "therapeutic", "decisions", "in", "impotent", "patients", ".", "Especially", "in", "recognition", "of", "our", "new", "treatment", "options", "such", "as", "oral", "sildenafil", ",", "a", "partner-", "and", "libido", "-", "oriented", "sexual", "counseling", "should", "accompany", "somatic", "therapy", "in", "most", "of", "our", "elderly", "patients", ".", "There", "exists", "no", "general", "\"", "sexology", "of", "the", "aging", "male", "\"", "but", "rather", "an", "individual", "sexual", "behavior", "and", "self", "-", "understanding", "that", "is", "transported", "into", "senescence", ".", "\"", "Zeitgeist", "\"", "-phenomena", ",", "partner", "problems", "and", "age", "-", "dependent", "physiologic", "changes", "can", "coincide", "and", "potentiate", "the", "resulting", "sexual", "dysfunction", ".", "Modern", "therapeutic", "plans", "should", "recognize", "these", "facts", "and", "create", "behaviour-", "and", "partner", "-", "oriented", "counseling", "strategies", "combined", "with", "minimally", "invasive", "somatic", "approaches", "." ]	[ "umlsterm" ]
knowledge, physiology, pathophysiology, male, erectile dysfunction, etiology - based, therapies, period, behavior, hand, life - span, resources, therapies, Sexology, men, interdisciplinary research, therapeutic, patients, recognition, treatment, sildenafil, sexual counseling, therapy, elderly, patients, sexology, male, behavior, self - understanding, senescence, sexual dysfunction, therapeutic, plans, behaviour-, counseling	Reproduktionsmedizin.90150133.eng.abstr_task2	Sentence: During the past 15 years urologists have acquired a widespread knowledge on physiology and pathophysiology of male erectile dysfunction and consequent etiology-based therapies . The same period was characterized by a profound change of sexual behavior and public appearance of sexual issues . On the other hand the socio-demographic effects of prolonged life-span and reduced socio-economic resources for reimbursement of medical therapies become visible . Sexology of aging men is an interdisciplinary research field ; its scientific results should be included into therapeutic decisions in impotent patients . Especially in recognition of our new treatment options such as oral sildenafil , a partner- and libido-oriented sexual counseling should accompany somatic therapy in most of our elderly patients . There exists no general " sexology of the aging male " but rather an individual sexual behavior and self-understanding that is transported into senescence . " Zeitgeist " -phenomena , partner problems and age-dependent physiologic changes can coincide and potentiate the resulting sexual dysfunction . Modern therapeutic plans should recognize these facts and create behaviour- and partner-oriented counseling strategies combined with minimally invasive somatic approaches . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O" ]	During the past 15 years urologists have acquired a widespread knowledge on physiology and pathophysiology of male erectile dysfunction and consequent etiology-based therapies . The same period was characterized by a profound change of sexual behavior and public appearance of sexual issues . On the other hand the socio-demographic effects of prolonged life-span and reduced socio-economic resources for reimbursement of medical therapies become visible . Sexology of aging men is an interdisciplinary research field ; its scientific results should be included into therapeutic decisions in impotent patients . Especially in recognition of our new treatment options such as oral sildenafil , a partner- and libido-oriented sexual counseling should accompany somatic therapy in most of our elderly patients . There exists no general " sexology of the aging male " but rather an individual sexual behavior and self-understanding that is transported into senescence . " Zeitgeist " -phenomena , partner problems and age-dependent physiologic changes can coincide and potentiate the resulting sexual dysfunction . Modern therapeutic plans should recognize these facts and create behaviour- and partner-oriented counseling strategies combined with minimally invasive somatic approaches .	[ "During", "the", "past", "15", "years", "urologists", "have", "acquired", "a", "widespread", "knowledge", "on", "physiology", "and", "pathophysiology", "of", "male", "erectile", "dysfunction", "and", "consequent", "etiology", "-", "based", "therapies", ".", "The", "same", "period", "was", "characterized", "by", "a", "profound", "change", "of", "sexual", "behavior", "and", "public", "appearance", "of", "sexual", "issues", ".", "On", "the", "other", "hand", "the", "socio", "-", "demographic", "effects", "of", "prolonged", "life", "-", "span", "and", "reduced", "socio", "-", "economic", "resources", "for", "reimbursement", "of", "medical", "therapies", "become", "visible", ".", "Sexology", "of", "aging", "men", "is", "an", "interdisciplinary", "research", "field", ";", "its", "scientific", "results", "should", "be", "included", "into", "therapeutic", "decisions", "in", "impotent", "patients", ".", "Especially", "in", "recognition", "of", "our", "new", "treatment", "options", "such", "as", "oral", "sildenafil", ",", "a", "partner-", "and", "libido", "-", "oriented", "sexual", "counseling", "should", "accompany", "somatic", "therapy", "in", "most", "of", "our", "elderly", "patients", ".", "There", "exists", "no", "general", "\"", "sexology", "of", "the", "aging", "male", "\"", "but", "rather", "an", "individual", "sexual", "behavior", "and", "self", "-", "understanding", "that", "is", "transported", "into", "senescence", ".", "\"", "Zeitgeist", "\"", "-phenomena", ",", "partner", "problems", "and", "age", "-", "dependent", "physiologic", "changes", "can", "coincide", "and", "potentiate", "the", "resulting", "sexual", "dysfunction", ".", "Modern", "therapeutic", "plans", "should", "recognize", "these", "facts", "and", "create", "behaviour-", "and", "partner", "-", "oriented", "counseling", "strategies", "combined", "with", "minimally", "invasive", "somatic", "approaches", "." ]	[ "umlsterm" ]
Pocket proteins is a Gene_or_gene_product, retinoblastoma protein is a Gene_or_gene_product, pRB is a Gene_or_gene_product, pRB is a Gene_or_gene_product, p107 is a Gene_or_gene_product, p130 is a Gene_or_gene_product, pocket protein is a Gene_or_gene_product, E2F is a Gene_or_gene_product, pRB is a Gene_or_gene_product, p107 is a Gene_or_gene_product, p130 is a Gene_or_gene_product, E2Fs is a Gene_or_gene_product, E2F is a Gene_or_gene_product, pocket proteins is a Gene_or_gene_product, Pocket proteins is a Gene_or_gene_product, E2F is a Gene_or_gene_product, Cdk2 is a Gene_or_gene_product, pocket protein is a Gene_or_gene_product, pocket protein is a Gene_or_gene_product, pocket proteins is a Gene_or_gene_product, pocket proteins is a Gene_or_gene_product	141_task0	Sentence: Pocket proteins and cell cycle control. The retinoblastoma protein (pRB) and the pRB-related p107 and p130 comprise the 'pocket protein' family of cell cycle regulators. These proteins are best known for their roles in restraining the G1-S transition through the regulation of E2F-responsive genes. pRB and the p107/p130 pair are required for the repression of distinct sets of genes, potentially due to their selective interactions with E2Fs that are engaged at specific promoter elements. In addition to regulating E2F-responsive genes in a reversible manner, pocket proteins contribute to silencing of such genes in cells that are undergoing senescence or differentiation. Pocket proteins also affect the G1-S transition through E2F-independent mechanisms, such as by inhibiting Cdk2 or by stabilizing p27(Kip1), and they are implicated in the control of G0 exit, the spatial organization of replication, and genomic rereplication. New insights into pocket protein regulation have also been obtained. Kinases previously thought to be crucial to pocket protein phosphorylation have been shown to be redundant, and new modes of phosphorylation and dephosphorylation have been identified. Despite these advances, much remains to be learned about the pocket proteins, particularly with regard to their developmental and tumor suppressor functions. Thus continues the story of the pocket proteins and the cell cycle. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Gene_or_gene_product	[ "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O" ]	Pocket proteins and cell cycle control. The retinoblastoma protein (pRB) and the pRB-related p107 and p130 comprise the 'pocket protein' family of cell cycle regulators. These proteins are best known for their roles in restraining the G1-S transition through the regulation of E2F-responsive genes. pRB and the p107/p130 pair are required for the repression of distinct sets of genes, potentially due to their selective interactions with E2Fs that are engaged at specific promoter elements. In addition to regulating E2F-responsive genes in a reversible manner, pocket proteins contribute to silencing of such genes in cells that are undergoing senescence or differentiation. Pocket proteins also affect the G1-S transition through E2F-independent mechanisms, such as by inhibiting Cdk2 or by stabilizing p27(Kip1), and they are implicated in the control of G0 exit, the spatial organization of replication, and genomic rereplication. New insights into pocket protein regulation have also been obtained. Kinases previously thought to be crucial to pocket protein phosphorylation have been shown to be redundant, and new modes of phosphorylation and dephosphorylation have been identified. Despite these advances, much remains to be learned about the pocket proteins, particularly with regard to their developmental and tumor suppressor functions. Thus continues the story of the pocket proteins and the cell cycle.	[ "Pocket", "proteins", "and", "cell", "cycle", "control", ".", "\n", "The", "retinoblastoma", "protein", "(", "pRB", ")", "and", "the", "pRB", "-", "related", "p107", "and", "p130", "comprise", "the", "'", "pocket", "protein", "'", "family", "of", "cell", "cycle", "regulators", ".", "These", "proteins", "are", "best", "known", "for", "their", "roles", "in", "restraining", "the", "G1-S", "transition", "through", "the", "regulation", "of", "E2F", "-", "responsive", "genes", ".", "pRB", "and", "the", "p107", "/", "p130", "pair", "are", "required", "for", "the", "repression", "of", "distinct", "sets", "of", "genes", ",", "potentially", "due", "to", "their", "selective", "interactions", "with", "E2Fs", "that", "are", "engaged", "at", "specific", "promoter", "elements", ".", "In", "addition", "to", "regulating", "E2F", "-", "responsive", "genes", "in", "a", "reversible", "manner", ",", "pocket", "proteins", "contribute", "to", "silencing", "of", "such", "genes", "in", "cells", "that", "are", "undergoing", "senescence", "or", "differentiation", ".", "Pocket", "proteins", "also", "affect", "the", "G1-S", "transition", "through", "E2F", "-", "independent", "mechanisms", ",", "such", "as", "by", "inhibiting", "Cdk2", "or", "by", "stabilizing", "p27(Kip1", ")", ",", "and", "they", "are", "implicated", "in", "the", "control", "of", "G0", "exit", ",", "the", "spatial", "organization", "of", "replication", ",", "and", "genomic", "rereplication", ".", "New", "insights", "into", "pocket", "protein", "regulation", "have", "also", "been", "obtained", ".", "Kinases", "previously", "thought", "to", "be", "crucial", "to", "pocket", "protein", "phosphorylation", "have", "been", "shown", "to", "be", "redundant", ",", "and", "new", "modes", "of", "phosphorylation", "and", "dephosphorylation", "have", "been", "identified", ".", "Despite", "these", "advances", ",", "much", "remains", "to", "be", "learned", "about", "the", "pocket", "proteins", ",", "particularly", "with", "regard", "to", "their", "developmental", "and", "tumor", "suppressor", "functions", ".", "Thus", "continues", "the", "story", "of", "the", "pocket", "proteins", "and", "the", "cell", "cycle", ".", "\n" ]	[ "Gene_or_gene_product" ]
Pocket proteins is a Gene_or_gene_product, retinoblastoma protein is a Gene_or_gene_product, pRB is a Gene_or_gene_product, pRB is a Gene_or_gene_product, p107 is a Gene_or_gene_product, p130 is a Gene_or_gene_product, pocket protein is a Gene_or_gene_product, E2F is a Gene_or_gene_product, pRB is a Gene_or_gene_product, p107 is a Gene_or_gene_product, p130 is a Gene_or_gene_product, E2Fs is a Gene_or_gene_product, E2F is a Gene_or_gene_product, pocket proteins is a Gene_or_gene_product, Pocket proteins is a Gene_or_gene_product, E2F is a Gene_or_gene_product, Cdk2 is a Gene_or_gene_product, pocket protein is a Gene_or_gene_product, pocket protein is a Gene_or_gene_product, pocket proteins is a Gene_or_gene_product, pocket proteins is a Gene_or_gene_product	141_task1	Sentence: Pocket proteins and cell cycle control. The retinoblastoma protein (pRB) and the pRB-related p107 and p130 comprise the 'pocket protein' family of cell cycle regulators. These proteins are best known for their roles in restraining the G1-S transition through the regulation of E2F-responsive genes. pRB and the p107/p130 pair are required for the repression of distinct sets of genes, potentially due to their selective interactions with E2Fs that are engaged at specific promoter elements. In addition to regulating E2F-responsive genes in a reversible manner, pocket proteins contribute to silencing of such genes in cells that are undergoing senescence or differentiation. Pocket proteins also affect the G1-S transition through E2F-independent mechanisms, such as by inhibiting Cdk2 or by stabilizing p27(Kip1), and they are implicated in the control of G0 exit, the spatial organization of replication, and genomic rereplication. New insights into pocket protein regulation have also been obtained. Kinases previously thought to be crucial to pocket protein phosphorylation have been shown to be redundant, and new modes of phosphorylation and dephosphorylation have been identified. Despite these advances, much remains to be learned about the pocket proteins, particularly with regard to their developmental and tumor suppressor functions. Thus continues the story of the pocket proteins and the cell cycle. Instructions: please typing these entity words according to sentence: Pocket proteins, retinoblastoma protein, pRB, pRB, p107, p130, pocket protein, E2F, pRB, p107, p130, E2Fs, E2F, pocket proteins, Pocket proteins, E2F, Cdk2, pocket protein, pocket protein, pocket proteins, pocket proteins Options: Gene_or_gene_product	[ "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O" ]	Pocket proteins and cell cycle control. The retinoblastoma protein (pRB) and the pRB-related p107 and p130 comprise the 'pocket protein' family of cell cycle regulators. These proteins are best known for their roles in restraining the G1-S transition through the regulation of E2F-responsive genes. pRB and the p107/p130 pair are required for the repression of distinct sets of genes, potentially due to their selective interactions with E2Fs that are engaged at specific promoter elements. In addition to regulating E2F-responsive genes in a reversible manner, pocket proteins contribute to silencing of such genes in cells that are undergoing senescence or differentiation. Pocket proteins also affect the G1-S transition through E2F-independent mechanisms, such as by inhibiting Cdk2 or by stabilizing p27(Kip1), and they are implicated in the control of G0 exit, the spatial organization of replication, and genomic rereplication. New insights into pocket protein regulation have also been obtained. Kinases previously thought to be crucial to pocket protein phosphorylation have been shown to be redundant, and new modes of phosphorylation and dephosphorylation have been identified. Despite these advances, much remains to be learned about the pocket proteins, particularly with regard to their developmental and tumor suppressor functions. Thus continues the story of the pocket proteins and the cell cycle.	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Pocket proteins, retinoblastoma protein, pRB, pRB, p107, p130, pocket protein, E2F, pRB, p107, p130, E2Fs, E2F, pocket proteins, Pocket proteins, E2F, Cdk2, pocket protein, pocket protein, pocket proteins, pocket proteins	141_task2	Sentence: Pocket proteins and cell cycle control. The retinoblastoma protein (pRB) and the pRB-related p107 and p130 comprise the 'pocket protein' family of cell cycle regulators. These proteins are best known for their roles in restraining the G1-S transition through the regulation of E2F-responsive genes. pRB and the p107/p130 pair are required for the repression of distinct sets of genes, potentially due to their selective interactions with E2Fs that are engaged at specific promoter elements. In addition to regulating E2F-responsive genes in a reversible manner, pocket proteins contribute to silencing of such genes in cells that are undergoing senescence or differentiation. Pocket proteins also affect the G1-S transition through E2F-independent mechanisms, such as by inhibiting Cdk2 or by stabilizing p27(Kip1), and they are implicated in the control of G0 exit, the spatial organization of replication, and genomic rereplication. New insights into pocket protein regulation have also been obtained. Kinases previously thought to be crucial to pocket protein phosphorylation have been shown to be redundant, and new modes of phosphorylation and dephosphorylation have been identified. Despite these advances, much remains to be learned about the pocket proteins, particularly with regard to their developmental and tumor suppressor functions. Thus continues the story of the pocket proteins and the cell cycle. Instructions: please extract entity words from the input sentence	[ "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O" ]	Pocket proteins and cell cycle control. The retinoblastoma protein (pRB) and the pRB-related p107 and p130 comprise the 'pocket protein' family of cell cycle regulators. These proteins are best known for their roles in restraining the G1-S transition through the regulation of E2F-responsive genes. pRB and the p107/p130 pair are required for the repression of distinct sets of genes, potentially due to their selective interactions with E2Fs that are engaged at specific promoter elements. In addition to regulating E2F-responsive genes in a reversible manner, pocket proteins contribute to silencing of such genes in cells that are undergoing senescence or differentiation. Pocket proteins also affect the G1-S transition through E2F-independent mechanisms, such as by inhibiting Cdk2 or by stabilizing p27(Kip1), and they are implicated in the control of G0 exit, the spatial organization of replication, and genomic rereplication. New insights into pocket protein regulation have also been obtained. Kinases previously thought to be crucial to pocket protein phosphorylation have been shown to be redundant, and new modes of phosphorylation and dephosphorylation have been identified. Despite these advances, much remains to be learned about the pocket proteins, particularly with regard to their developmental and tumor suppressor functions. Thus continues the story of the pocket proteins and the cell cycle.	[ "Pocket", "proteins", "and", "cell", "cycle", "control", ".", "\n", "The", "retinoblastoma", "protein", "(", "pRB", ")", "and", "the", "pRB", "-", "related", "p107", "and", "p130", "comprise", "the", "'", "pocket", "protein", "'", "family", "of", "cell", "cycle", "regulators", ".", "These", "proteins", "are", "best", "known", "for", "their", "roles", "in", "restraining", "the", "G1-S", "transition", "through", "the", "regulation", "of", "E2F", "-", "responsive", "genes", ".", "pRB", "and", "the", "p107", "/", "p130", "pair", "are", "required", "for", "the", "repression", "of", "distinct", "sets", "of", "genes", ",", "potentially", "due", "to", "their", "selective", "interactions", "with", "E2Fs", "that", "are", "engaged", "at", "specific", "promoter", "elements", ".", "In", "addition", "to", "regulating", "E2F", "-", "responsive", "genes", "in", "a", "reversible", "manner", ",", "pocket", "proteins", "contribute", "to", "silencing", "of", "such", "genes", "in", "cells", "that", "are", "undergoing", "senescence", "or", "differentiation", ".", "Pocket", "proteins", "also", "affect", "the", "G1-S", "transition", "through", "E2F", "-", "independent", "mechanisms", ",", "such", "as", "by", "inhibiting", "Cdk2", "or", "by", "stabilizing", "p27(Kip1", ")", ",", "and", "they", "are", "implicated", "in", "the", "control", "of", "G0", "exit", ",", "the", "spatial", "organization", "of", "replication", ",", "and", "genomic", "rereplication", ".", "New", "insights", "into", "pocket", "protein", "regulation", "have", "also", "been", "obtained", ".", "Kinases", "previously", "thought", "to", "be", "crucial", "to", "pocket", "protein", "phosphorylation", "have", "been", "shown", "to", "be", "redundant", ",", "and", "new", "modes", "of", "phosphorylation", "and", "dephosphorylation", "have", "been", "identified", ".", "Despite", "these", "advances", ",", "much", "remains", "to", "be", "learned", "about", "the", "pocket", "proteins", ",", "particularly", "with", "regard", "to", "their", "developmental", "and", "tumor", "suppressor", "functions", ".", "Thus", "continues", "the", "story", "of", "the", "pocket", "proteins", "and", "the", "cell", "cycle", ".", "\n" ]	[ "Gene_or_gene_product" ]
cancer cells is a Cell, Ehrlich ascites is a Cell, L1210 murine leukemia cells is a Cell, tumor cells is a Cell, Ehrlich cells is a Cell, cell membrane is a Cellular_component	PMID-8272146_task0	Sentence: Effect of 1-alkylpyrrolidine N-oxides on energy metabolism of cancer cells. The main purpose of the present investigation was to study the effect of a homologous series of 1-alkylpyrrolidine N-oxides on ATP-producing processes in Ehrlich ascites and L1210 murine leukemia cells. The effect on aerobic glucose consumption, lactic acid formation, content of total (T-SH) and non-protein thiol groups (NP-SH), endogenous respiration and the level of ATP in tumor cells incubated in vitro was investigated. 1-Tetradecylpyrrolidine N-oxide (TPNO), one of the most active compounds, immediately after addition to the suspension of Ehrlich cells in an ice bath, decreased the level of ATP to the same extent over the whole concentration range. After 2 h incubation at 37 degrees C the drop in the ATP level was lower. The decrease in ATP level might be explained through the interaction of the amine oxide with the cell membrane integrity. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Cellular_component, Cell	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "O", "B-Cell", "I-Cell", "I-Cell", "I-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cellular_component", "I-Cellular_component", "O", "O", "O" ]	Effect of 1-alkylpyrrolidine N-oxides on energy metabolism of cancer cells. The main purpose of the present investigation was to study the effect of a homologous series of 1-alkylpyrrolidine N-oxides on ATP-producing processes in Ehrlich ascites and L1210 murine leukemia cells. The effect on aerobic glucose consumption, lactic acid formation, content of total (T-SH) and non-protein thiol groups (NP-SH), endogenous respiration and the level of ATP in tumor cells incubated in vitro was investigated. 1-Tetradecylpyrrolidine N-oxide (TPNO), one of the most active compounds, immediately after addition to the suspension of Ehrlich cells in an ice bath, decreased the level of ATP to the same extent over the whole concentration range. After 2 h incubation at 37 degrees C the drop in the ATP level was lower. The decrease in ATP level might be explained through the interaction of the amine oxide with the cell membrane integrity.	[ "Effect", "of", "1-alkylpyrrolidine", "N", "-", "oxides", "on", "energy", "metabolism", "of", "cancer", "cells", ".", "\n", "The", "main", "purpose", "of", "the", "present", "investigation", "was", "to", "study", "the", "effect", "of", "a", "homologous", "series", "of", "1-alkylpyrrolidine", "N", "-", "oxides", "on", "ATP", "-", "producing", "processes", "in", "Ehrlich", "ascites", "and", "L1210", "murine", "leukemia", "cells", ".", "The", "effect", "on", "aerobic", "glucose", "consumption", ",", "lactic", "acid", "formation", ",", "content", "of", "total", "(", "T", "-", "SH", ")", "and", "non", "-", "protein", "thiol", "groups", "(", "NP", "-", "SH", ")", ",", "endogenous", "respiration", "and", "the", "level", "of", "ATP", "in", "tumor", "cells", "incubated", "in", "vitro", "was", "investigated", ".", "1-Tetradecylpyrrolidine", "N", "-", "oxide", "(", "TPNO", ")", ",", "one", "of", "the", "most", "active", "compounds", ",", "immediately", "after", "addition", "to", "the", "suspension", "of", "Ehrlich", "cells", "in", "an", "ice", "bath", ",", "decreased", "the", "level", "of", "ATP", "to", "the", "same", "extent", "over", "the", "whole", "concentration", "range", ".", "After", "2", "h", "incubation", "at", "37", "degrees", "C", "the", "drop", "in", "the", "ATP", "level", "was", "lower", ".", "The", "decrease", "in", "ATP", "level", "might", "be", "explained", "through", "the", "interaction", "of", "the", "amine", "oxide", "with", "the", "cell", "membrane", "integrity", ".", "\n" ]	[ "Cell", "Cellular_component" ]
cancer cells is a Cell, Ehrlich ascites is a Cell, L1210 murine leukemia cells is a Cell, tumor cells is a Cell, Ehrlich cells is a Cell, cell membrane is a Cellular_component	PMID-8272146_task1	Sentence: Effect of 1-alkylpyrrolidine N-oxides on energy metabolism of cancer cells. The main purpose of the present investigation was to study the effect of a homologous series of 1-alkylpyrrolidine N-oxides on ATP-producing processes in Ehrlich ascites and L1210 murine leukemia cells. The effect on aerobic glucose consumption, lactic acid formation, content of total (T-SH) and non-protein thiol groups (NP-SH), endogenous respiration and the level of ATP in tumor cells incubated in vitro was investigated. 1-Tetradecylpyrrolidine N-oxide (TPNO), one of the most active compounds, immediately after addition to the suspension of Ehrlich cells in an ice bath, decreased the level of ATP to the same extent over the whole concentration range. After 2 h incubation at 37 degrees C the drop in the ATP level was lower. The decrease in ATP level might be explained through the interaction of the amine oxide with the cell membrane integrity. Instructions: please typing these entity words according to sentence: cancer cells, Ehrlich ascites, L1210 murine leukemia cells, tumor cells, Ehrlich cells, cell membrane Options: Cellular_component, Cell	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "O", "B-Cell", "I-Cell", "I-Cell", "I-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cellular_component", "I-Cellular_component", "O", "O", "O" ]	Effect of 1-alkylpyrrolidine N-oxides on energy metabolism of cancer cells. The main purpose of the present investigation was to study the effect of a homologous series of 1-alkylpyrrolidine N-oxides on ATP-producing processes in Ehrlich ascites and L1210 murine leukemia cells. The effect on aerobic glucose consumption, lactic acid formation, content of total (T-SH) and non-protein thiol groups (NP-SH), endogenous respiration and the level of ATP in tumor cells incubated in vitro was investigated. 1-Tetradecylpyrrolidine N-oxide (TPNO), one of the most active compounds, immediately after addition to the suspension of Ehrlich cells in an ice bath, decreased the level of ATP to the same extent over the whole concentration range. After 2 h incubation at 37 degrees C the drop in the ATP level was lower. The decrease in ATP level might be explained through the interaction of the amine oxide with the cell membrane integrity.	[ "Effect", "of", "1-alkylpyrrolidine", "N", "-", "oxides", "on", "energy", "metabolism", "of", "cancer", "cells", ".", "\n", "The", "main", "purpose", "of", "the", "present", "investigation", "was", "to", "study", "the", "effect", "of", "a", "homologous", "series", "of", "1-alkylpyrrolidine", "N", "-", "oxides", "on", "ATP", "-", "producing", "processes", "in", "Ehrlich", "ascites", "and", "L1210", "murine", "leukemia", "cells", ".", "The", "effect", "on", "aerobic", "glucose", "consumption", ",", "lactic", "acid", "formation", ",", "content", "of", "total", "(", "T", "-", "SH", ")", "and", "non", "-", "protein", "thiol", "groups", "(", "NP", "-", "SH", ")", ",", "endogenous", "respiration", "and", "the", "level", "of", "ATP", "in", "tumor", "cells", "incubated", "in", "vitro", "was", "investigated", ".", "1-Tetradecylpyrrolidine", "N", "-", "oxide", "(", "TPNO", ")", ",", "one", "of", "the", "most", "active", "compounds", ",", "immediately", "after", "addition", "to", "the", "suspension", "of", "Ehrlich", "cells", "in", "an", "ice", "bath", ",", "decreased", "the", "level", "of", "ATP", "to", "the", "same", "extent", "over", "the", "whole", "concentration", "range", ".", "After", "2", "h", "incubation", "at", "37", "degrees", "C", "the", "drop", "in", "the", "ATP", "level", "was", "lower", ".", "The", "decrease", "in", "ATP", "level", "might", "be", "explained", "through", "the", "interaction", "of", "the", "amine", "oxide", "with", "the", "cell", "membrane", "integrity", ".", "\n" ]	[ "Cell", "Cellular_component" ]
cancer cells, Ehrlich ascites, L1210 murine leukemia cells, tumor cells, Ehrlich cells, cell membrane	PMID-8272146_task2	Sentence: Effect of 1-alkylpyrrolidine N-oxides on energy metabolism of cancer cells. The main purpose of the present investigation was to study the effect of a homologous series of 1-alkylpyrrolidine N-oxides on ATP-producing processes in Ehrlich ascites and L1210 murine leukemia cells. The effect on aerobic glucose consumption, lactic acid formation, content of total (T-SH) and non-protein thiol groups (NP-SH), endogenous respiration and the level of ATP in tumor cells incubated in vitro was investigated. 1-Tetradecylpyrrolidine N-oxide (TPNO), one of the most active compounds, immediately after addition to the suspension of Ehrlich cells in an ice bath, decreased the level of ATP to the same extent over the whole concentration range. After 2 h incubation at 37 degrees C the drop in the ATP level was lower. The decrease in ATP level might be explained through the interaction of the amine oxide with the cell membrane integrity. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "O", "B-Cell", "I-Cell", "I-Cell", "I-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "I-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cellular_component", "I-Cellular_component", "O", "O", "O" ]	Effect of 1-alkylpyrrolidine N-oxides on energy metabolism of cancer cells. The main purpose of the present investigation was to study the effect of a homologous series of 1-alkylpyrrolidine N-oxides on ATP-producing processes in Ehrlich ascites and L1210 murine leukemia cells. The effect on aerobic glucose consumption, lactic acid formation, content of total (T-SH) and non-protein thiol groups (NP-SH), endogenous respiration and the level of ATP in tumor cells incubated in vitro was investigated. 1-Tetradecylpyrrolidine N-oxide (TPNO), one of the most active compounds, immediately after addition to the suspension of Ehrlich cells in an ice bath, decreased the level of ATP to the same extent over the whole concentration range. After 2 h incubation at 37 degrees C the drop in the ATP level was lower. The decrease in ATP level might be explained through the interaction of the amine oxide with the cell membrane integrity.	[ "Effect", "of", "1-alkylpyrrolidine", "N", "-", "oxides", "on", "energy", "metabolism", "of", "cancer", "cells", ".", "\n", "The", "main", "purpose", "of", "the", "present", "investigation", "was", "to", "study", "the", "effect", "of", "a", "homologous", "series", "of", "1-alkylpyrrolidine", "N", "-", "oxides", "on", "ATP", "-", "producing", "processes", "in", "Ehrlich", "ascites", "and", "L1210", "murine", "leukemia", "cells", ".", "The", "effect", "on", "aerobic", "glucose", "consumption", ",", "lactic", "acid", "formation", ",", "content", "of", "total", "(", "T", "-", "SH", ")", "and", "non", "-", "protein", "thiol", "groups", "(", "NP", "-", "SH", ")", ",", "endogenous", "respiration", "and", "the", "level", "of", "ATP", "in", "tumor", "cells", "incubated", "in", "vitro", "was", "investigated", ".", "1-Tetradecylpyrrolidine", "N", "-", "oxide", "(", "TPNO", ")", ",", "one", "of", "the", "most", "active", "compounds", ",", "immediately", "after", "addition", "to", "the", "suspension", "of", "Ehrlich", "cells", "in", "an", "ice", "bath", ",", "decreased", "the", "level", "of", "ATP", "to", "the", "same", "extent", "over", "the", "whole", "concentration", "range", ".", "After", "2", "h", "incubation", "at", "37", "degrees", "C", "the", "drop", "in", "the", "ATP", "level", "was", "lower", ".", "The", "decrease", "in", "ATP", "level", "might", "be", "explained", "through", "the", "interaction", "of", "the", "amine", "oxide", "with", "the", "cell", "membrane", "integrity", ".", "\n" ]	[ "Cell", "Cellular_component" ]
Infektionen is an umlsterm, zerebrale Ischaemien is an umlsterm, Infektionen is an umlsterm, Risiko is an umlsterm, Infarkte is an umlsterm, Arteriosklerose is an umlsterm, Infektionen is an umlsterm, Patienten is an umlsterm, geschlechtsentsprechende is an umlsterm, Patienten is an umlsterm, Zahnstatus is an umlsterm, Karies is an umlsterm, Parodontitis is an umlsterm, Zaehne is an umlsterm, Patienten is an umlsterm, zerebralen Ischaemie is an umlsterm, Zahnstatus is an umlsterm, Zahnstatus is an umlsterm, Ischaemie is an umlsterm, Risikofaktoren is an umlsterm, Zahngesundheit is an umlsterm, Infektionen is an umlsterm, Risiko is an umlsterm, Ischaemien is an umlsterm, Infektionen is an umlsterm, Rolle is an umlsterm, Praeventivmedizin is an umlsterm	MundKieferGesichtschirurgie.80020316.ger.abstr_task0	Sentence: Fruehere Studien haben gezeigt , dass akute Infektionen , insbesondere der Atemwege , einen wichtigen Risikofaktor fuer zerebrale Ischaemien darstellen . Weiterhin wissen wir , dass chronische odontogene Infektionen ein Risiko fuer myokardiale Infarkte und Arteriosklerose sein koennen . Der Zusammenhang zwischen zerebralen Insulten und dentalen Infektionen wurde jedoch bislang kaum untersucht . Daher fuehrten wir eine Fall-Kontroll-Studie unter Anwendung eines standardisierten Erhebungsbogens und Untersuchungsprotokolls durch . Es wurden 66 Patienten mit einer akuten zerebralen Ischaemie/Insult sowie 60 weitere alters- und geschlechtsentsprechende neurologische Patienten als Kontrollgruppe untersucht . Der Zahnstatus wurde durch einen sog . Total-Dental-Index ( TDI ) , welcher in erster Linie Karies Parodontitis , , periapikale Laesionen , devitale und fehlende Zaehne beruecksichtigt , sowie durch einen Panoramaschichtindex ( PI ) erfasst . Speziell aeltere Patienten mit einer zerebralen Ischaemie wiesen tendenziell einen signifikant schlechteren Zahnstatus auf und besassen deutlich oefter Parodopathien und apikale Laesionen als Kontrollpersonen . Ein vorbestehender schlechter Zahnstatus war verknuepft mit einer zerebrovaskulaeren Ischaemie unabhaengig von anderen vaskulaeren Risikofaktoren und dem sozialen Status . Zusammenfassend gesagt , kann eine schlechte Zahngesundheit , v.a. aus chronischen odontogenen Infektionen resultierend , mit einem erhoehten Risiko fuer zerebrovaskulaere Ischaemien verbunden sein . Die Ergebnisse muessen nun in groesseren Folgestudien verifiziert werden . Da chronische dentale Infektionen weit verbreitete und ebenso leicht therapierbare Faktoren darstellen , wuerde ihre Identifikation als Risikofaktor fuer einen Insult eine ziemlich wichtige Rolle im Bereich der Praeventivmedizin spielen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O" ]	Fruehere Studien haben gezeigt , dass akute Infektionen , insbesondere der Atemwege , einen wichtigen Risikofaktor fuer zerebrale Ischaemien darstellen . Weiterhin wissen wir , dass chronische odontogene Infektionen ein Risiko fuer myokardiale Infarkte und Arteriosklerose sein koennen . Der Zusammenhang zwischen zerebralen Insulten und dentalen Infektionen wurde jedoch bislang kaum untersucht . Daher fuehrten wir eine Fall-Kontroll-Studie unter Anwendung eines standardisierten Erhebungsbogens und Untersuchungsprotokolls durch . Es wurden 66 Patienten mit einer akuten zerebralen Ischaemie/Insult sowie 60 weitere alters- und geschlechtsentsprechende neurologische Patienten als Kontrollgruppe untersucht . Der Zahnstatus wurde durch einen sog . Total-Dental-Index ( TDI ) , welcher in erster Linie Karies Parodontitis , , periapikale Laesionen , devitale und fehlende Zaehne beruecksichtigt , sowie durch einen Panoramaschichtindex ( PI ) erfasst . Speziell aeltere Patienten mit einer zerebralen Ischaemie wiesen tendenziell einen signifikant schlechteren Zahnstatus auf und besassen deutlich oefter Parodopathien und apikale Laesionen als Kontrollpersonen . Ein vorbestehender schlechter Zahnstatus war verknuepft mit einer zerebrovaskulaeren Ischaemie unabhaengig von anderen vaskulaeren Risikofaktoren und dem sozialen Status . Zusammenfassend gesagt , kann eine schlechte Zahngesundheit , v.a. aus chronischen odontogenen Infektionen resultierend , mit einem erhoehten Risiko fuer zerebrovaskulaere Ischaemien verbunden sein . Die Ergebnisse muessen nun in groesseren Folgestudien verifiziert werden . Da chronische dentale Infektionen weit verbreitete und ebenso leicht therapierbare Faktoren darstellen , wuerde ihre Identifikation als Risikofaktor fuer einen Insult eine ziemlich wichtige Rolle im Bereich der Praeventivmedizin spielen .	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Infektionen is an umlsterm, zerebrale Ischaemien is an umlsterm, Infektionen is an umlsterm, Risiko is an umlsterm, Infarkte is an umlsterm, Arteriosklerose is an umlsterm, Infektionen is an umlsterm, Patienten is an umlsterm, geschlechtsentsprechende is an umlsterm, Patienten is an umlsterm, Zahnstatus is an umlsterm, Karies is an umlsterm, Parodontitis is an umlsterm, Zaehne is an umlsterm, Patienten is an umlsterm, zerebralen Ischaemie is an umlsterm, Zahnstatus is an umlsterm, Zahnstatus is an umlsterm, Ischaemie is an umlsterm, Risikofaktoren is an umlsterm, Zahngesundheit is an umlsterm, Infektionen is an umlsterm, Risiko is an umlsterm, Ischaemien is an umlsterm, Infektionen is an umlsterm, Rolle is an umlsterm, Praeventivmedizin is an umlsterm	MundKieferGesichtschirurgie.80020316.ger.abstr_task1	Sentence: Fruehere Studien haben gezeigt , dass akute Infektionen , insbesondere der Atemwege , einen wichtigen Risikofaktor fuer zerebrale Ischaemien darstellen . Weiterhin wissen wir , dass chronische odontogene Infektionen ein Risiko fuer myokardiale Infarkte und Arteriosklerose sein koennen . Der Zusammenhang zwischen zerebralen Insulten und dentalen Infektionen wurde jedoch bislang kaum untersucht . Daher fuehrten wir eine Fall-Kontroll-Studie unter Anwendung eines standardisierten Erhebungsbogens und Untersuchungsprotokolls durch . Es wurden 66 Patienten mit einer akuten zerebralen Ischaemie/Insult sowie 60 weitere alters- und geschlechtsentsprechende neurologische Patienten als Kontrollgruppe untersucht . Der Zahnstatus wurde durch einen sog . Total-Dental-Index ( TDI ) , welcher in erster Linie Karies Parodontitis , , periapikale Laesionen , devitale und fehlende Zaehne beruecksichtigt , sowie durch einen Panoramaschichtindex ( PI ) erfasst . Speziell aeltere Patienten mit einer zerebralen Ischaemie wiesen tendenziell einen signifikant schlechteren Zahnstatus auf und besassen deutlich oefter Parodopathien und apikale Laesionen als Kontrollpersonen . Ein vorbestehender schlechter Zahnstatus war verknuepft mit einer zerebrovaskulaeren Ischaemie unabhaengig von anderen vaskulaeren Risikofaktoren und dem sozialen Status . Zusammenfassend gesagt , kann eine schlechte Zahngesundheit , v.a. aus chronischen odontogenen Infektionen resultierend , mit einem erhoehten Risiko fuer zerebrovaskulaere Ischaemien verbunden sein . Die Ergebnisse muessen nun in groesseren Folgestudien verifiziert werden . Da chronische dentale Infektionen weit verbreitete und ebenso leicht therapierbare Faktoren darstellen , wuerde ihre Identifikation als Risikofaktor fuer einen Insult eine ziemlich wichtige Rolle im Bereich der Praeventivmedizin spielen . Instructions: please typing these entity words according to sentence: Infektionen, zerebrale Ischaemien, Infektionen, Risiko, Infarkte, Arteriosklerose, Infektionen, Patienten, geschlechtsentsprechende, Patienten, Zahnstatus, Karies, Parodontitis, Zaehne, Patienten, zerebralen Ischaemie, Zahnstatus, Zahnstatus, Ischaemie, Risikofaktoren, Zahngesundheit, Infektionen, Risiko, Ischaemien, Infektionen, Rolle, Praeventivmedizin Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O" ]	Fruehere Studien haben gezeigt , dass akute Infektionen , insbesondere der Atemwege , einen wichtigen Risikofaktor fuer zerebrale Ischaemien darstellen . Weiterhin wissen wir , dass chronische odontogene Infektionen ein Risiko fuer myokardiale Infarkte und Arteriosklerose sein koennen . Der Zusammenhang zwischen zerebralen Insulten und dentalen Infektionen wurde jedoch bislang kaum untersucht . Daher fuehrten wir eine Fall-Kontroll-Studie unter Anwendung eines standardisierten Erhebungsbogens und Untersuchungsprotokolls durch . Es wurden 66 Patienten mit einer akuten zerebralen Ischaemie/Insult sowie 60 weitere alters- und geschlechtsentsprechende neurologische Patienten als Kontrollgruppe untersucht . Der Zahnstatus wurde durch einen sog . Total-Dental-Index ( TDI ) , welcher in erster Linie Karies Parodontitis , , periapikale Laesionen , devitale und fehlende Zaehne beruecksichtigt , sowie durch einen Panoramaschichtindex ( PI ) erfasst . Speziell aeltere Patienten mit einer zerebralen Ischaemie wiesen tendenziell einen signifikant schlechteren Zahnstatus auf und besassen deutlich oefter Parodopathien und apikale Laesionen als Kontrollpersonen . Ein vorbestehender schlechter Zahnstatus war verknuepft mit einer zerebrovaskulaeren Ischaemie unabhaengig von anderen vaskulaeren Risikofaktoren und dem sozialen Status . Zusammenfassend gesagt , kann eine schlechte Zahngesundheit , v.a. aus chronischen odontogenen Infektionen resultierend , mit einem erhoehten Risiko fuer zerebrovaskulaere Ischaemien verbunden sein . Die Ergebnisse muessen nun in groesseren Folgestudien verifiziert werden . Da chronische dentale Infektionen weit verbreitete und ebenso leicht therapierbare Faktoren darstellen , wuerde ihre Identifikation als Risikofaktor fuer einen Insult eine ziemlich wichtige Rolle im Bereich der Praeventivmedizin spielen .	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Infektionen, zerebrale Ischaemien, Infektionen, Risiko, Infarkte, Arteriosklerose, Infektionen, Patienten, geschlechtsentsprechende, Patienten, Zahnstatus, Karies, Parodontitis, Zaehne, Patienten, zerebralen Ischaemie, Zahnstatus, Zahnstatus, Ischaemie, Risikofaktoren, Zahngesundheit, Infektionen, Risiko, Ischaemien, Infektionen, Rolle, Praeventivmedizin	MundKieferGesichtschirurgie.80020316.ger.abstr_task2	Sentence: Fruehere Studien haben gezeigt , dass akute Infektionen , insbesondere der Atemwege , einen wichtigen Risikofaktor fuer zerebrale Ischaemien darstellen . Weiterhin wissen wir , dass chronische odontogene Infektionen ein Risiko fuer myokardiale Infarkte und Arteriosklerose sein koennen . Der Zusammenhang zwischen zerebralen Insulten und dentalen Infektionen wurde jedoch bislang kaum untersucht . Daher fuehrten wir eine Fall-Kontroll-Studie unter Anwendung eines standardisierten Erhebungsbogens und Untersuchungsprotokolls durch . Es wurden 66 Patienten mit einer akuten zerebralen Ischaemie/Insult sowie 60 weitere alters- und geschlechtsentsprechende neurologische Patienten als Kontrollgruppe untersucht . Der Zahnstatus wurde durch einen sog . Total-Dental-Index ( TDI ) , welcher in erster Linie Karies Parodontitis , , periapikale Laesionen , devitale und fehlende Zaehne beruecksichtigt , sowie durch einen Panoramaschichtindex ( PI ) erfasst . Speziell aeltere Patienten mit einer zerebralen Ischaemie wiesen tendenziell einen signifikant schlechteren Zahnstatus auf und besassen deutlich oefter Parodopathien und apikale Laesionen als Kontrollpersonen . Ein vorbestehender schlechter Zahnstatus war verknuepft mit einer zerebrovaskulaeren Ischaemie unabhaengig von anderen vaskulaeren Risikofaktoren und dem sozialen Status . Zusammenfassend gesagt , kann eine schlechte Zahngesundheit , v.a. aus chronischen odontogenen Infektionen resultierend , mit einem erhoehten Risiko fuer zerebrovaskulaere Ischaemien verbunden sein . Die Ergebnisse muessen nun in groesseren Folgestudien verifiziert werden . Da chronische dentale Infektionen weit verbreitete und ebenso leicht therapierbare Faktoren darstellen , wuerde ihre Identifikation als Risikofaktor fuer einen Insult eine ziemlich wichtige Rolle im Bereich der Praeventivmedizin spielen . 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Weiterhin wissen wir , dass chronische odontogene Infektionen ein Risiko fuer myokardiale Infarkte und Arteriosklerose sein koennen . Der Zusammenhang zwischen zerebralen Insulten und dentalen Infektionen wurde jedoch bislang kaum untersucht . Daher fuehrten wir eine Fall-Kontroll-Studie unter Anwendung eines standardisierten Erhebungsbogens und Untersuchungsprotokolls durch . Es wurden 66 Patienten mit einer akuten zerebralen Ischaemie/Insult sowie 60 weitere alters- und geschlechtsentsprechende neurologische Patienten als Kontrollgruppe untersucht . Der Zahnstatus wurde durch einen sog . Total-Dental-Index ( TDI ) , welcher in erster Linie Karies Parodontitis , , periapikale Laesionen , devitale und fehlende Zaehne beruecksichtigt , sowie durch einen Panoramaschichtindex ( PI ) erfasst . Speziell aeltere Patienten mit einer zerebralen Ischaemie wiesen tendenziell einen signifikant schlechteren Zahnstatus auf und besassen deutlich oefter Parodopathien und apikale Laesionen als Kontrollpersonen . Ein vorbestehender schlechter Zahnstatus war verknuepft mit einer zerebrovaskulaeren Ischaemie unabhaengig von anderen vaskulaeren Risikofaktoren und dem sozialen Status . Zusammenfassend gesagt , kann eine schlechte Zahngesundheit , v.a. aus chronischen odontogenen Infektionen resultierend , mit einem erhoehten Risiko fuer zerebrovaskulaere Ischaemien verbunden sein . Die Ergebnisse muessen nun in groesseren Folgestudien verifiziert werden . Da chronische dentale Infektionen weit verbreitete und ebenso leicht therapierbare Faktoren darstellen , wuerde ihre Identifikation als Risikofaktor fuer einen Insult eine ziemlich wichtige Rolle im Bereich der Praeventivmedizin spielen .	[ "Fruehere", "Studien", "haben", "gezeigt", ",", "dass", "akute", "Infektionen", ",", "insbesondere", "der", "Atemwege", ",", "einen", "wichtigen", "Risikofaktor", "fuer", "zerebrale", "Ischaemien", "darstellen", ".", "Weiterhin", "wissen", "wir", ",", "dass", "chronische", "odontogene", "Infektionen", "ein", "Risiko", "fuer", "myokardiale", "Infarkte", "und", "Arteriosklerose", "sein", "koennen", ".", "Der", "Zusammenhang", "zwischen", "zerebralen", "Insulten", "und", "dentalen", "Infektionen", "wurde", "jedoch", "bislang", "kaum", "untersucht", ".", "Daher", "fuehrten", "wir", "eine", "Fall", "-", "Kontroll", "-", "Studie", "unter", "Anwendung", "eines", "standardisierten", "Erhebungsbogens", "und", "Untersuchungsprotokolls", "durch", ".", "Es", "wurden", "66", "Patienten", "mit", "einer", "akuten", "zerebralen", "Ischaemie", "/", "Insult", "sowie", "60", "weitere", "alters-", "und", "geschlechtsentsprechende", "neurologische", "Patienten", "als", "Kontrollgruppe", "untersucht", ".", "Der", "Zahnstatus", "wurde", "durch", "einen", "sog", ".", "Total", "-", "Dental", "-", "Index", "(", "TDI", ")", ",", "welcher", "in", "erster", "Linie", "Karies", "Parodontitis", ",", ",", "periapikale", "Laesionen", ",", "devitale", "und", "fehlende", "Zaehne", "beruecksichtigt", ",", "sowie", "durch", "einen", "Panoramaschichtindex", "(", "PI", ")", "erfasst", ".", "Speziell", "aeltere", "Patienten", "mit", "einer", "zerebralen", "Ischaemie", "wiesen", "tendenziell", "einen", "signifikant", "schlechteren", "Zahnstatus", "auf", "und", "besassen", "deutlich", "oefter", "Parodopathien", "und", "apikale", "Laesionen", "als", "Kontrollpersonen", ".", "Ein", "vorbestehender", "schlechter", "Zahnstatus", "war", "verknuepft", "mit", "einer", "zerebrovaskulaeren", "Ischaemie", "unabhaengig", "von", "anderen", "vaskulaeren", "Risikofaktoren", "und", "dem", "sozialen", "Status", ".", "Zusammenfassend", "gesagt", ",", "kann", "eine", "schlechte", "Zahngesundheit", ",", "v.a", ".", "aus", "chronischen", "odontogenen", "Infektionen", "resultierend", ",", "mit", "einem", "erhoehten", "Risiko", "fuer", "zerebrovaskulaere", "Ischaemien", "verbunden", "sein", ".", "Die", "Ergebnisse", "muessen", "nun", "in", "groesseren", "Folgestudien", "verifiziert", "werden", ".", "Da", "chronische", "dentale", "Infektionen", "weit", "verbreitete", "und", "ebenso", "leicht", "therapierbare", "Faktoren", "darstellen", ",", "wuerde", "ihre", "Identifikation", "als", "Risikofaktor", "fuer", "einen", "Insult", "eine", "ziemlich", "wichtige", "Rolle", "im", "Bereich", "der", "Praeventivmedizin", "spielen", "." ]	[ "umlsterm" ]
body composition is an umlsterm, thirst is an umlsterm, perception is an umlsterm, function is an umlsterm, regulatory is an umlsterm, maintenance is an umlsterm, water is an umlsterm, sodium is an umlsterm, balance is an umlsterm, diseases is an umlsterm, drugs is an umlsterm, elderly is an umlsterm, water is an umlsterm, sodium is an umlsterm, symptoms is an umlsterm, morbidity is an umlsterm, mortality is an umlsterm, disorders is an umlsterm, dehydration is an umlsterm, hypernatremia is an umlsterm, hyponatremia is an umlsterm, frequency is an umlsterm, urinary incontinence is an umlsterm, elderly is an umlsterm, person is an umlsterm, risk is an umlsterm, water is an umlsterm, sodium is an umlsterm, balance is an umlsterm	ZfuerGerontologie+Geriatrie.9032s020.eng.abstr_task0	Sentence: Normal aging is associated with changes in body composition , thirst perception , renal function , and the hormonal regulatory systems involved in the maintenance of water and sodium balance . The presence of many diseases and drugs common in the elderly can interact with the impaired homeostatic systems to result in clinically significant disturbances of water and sodium with accompanying symptoms , morbidity , and mortality . These disorders , which include dehydration , hypernatremia , hyponatremia , urinary frequency , and urinary incontinence can either be prevented or promptly recognized and appropriately treated by understanding the physiological changes and clinical circumstances which put the elderly person at increased risk for deranged water and sodium balance . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O" ]	Normal aging is associated with changes in body composition , thirst perception , renal function , and the hormonal regulatory systems involved in the maintenance of water and sodium balance . The presence of many diseases and drugs common in the elderly can interact with the impaired homeostatic systems to result in clinically significant disturbances of water and sodium with accompanying symptoms , morbidity , and mortality . These disorders , which include dehydration , hypernatremia , hyponatremia , urinary frequency , and urinary incontinence can either be prevented or promptly recognized and appropriately treated by understanding the physiological changes and clinical circumstances which put the elderly person at increased risk for deranged water and sodium balance .	[ "Normal", "aging", "is", "associated", "with", "changes", "in", "body", "composition", ",", "thirst", "perception", ",", "renal", "function", ",", "and", "the", "hormonal", "regulatory", "systems", "involved", "in", "the", "maintenance", "of", "water", "and", "sodium", "balance", ".", "The", "presence", "of", "many", "diseases", "and", "drugs", "common", "in", "the", "elderly", "can", "interact", "with", "the", "impaired", "homeostatic", "systems", "to", "result", "in", "clinically", "significant", "disturbances", "of", "water", "and", "sodium", "with", "accompanying", "symptoms", ",", "morbidity", ",", "and", "mortality", ".", "These", "disorders", ",", "which", "include", "dehydration", ",", "hypernatremia", ",", "hyponatremia", ",", "urinary", "frequency", ",", "and", "urinary", "incontinence", "can", "either", "be", "prevented", "or", "promptly", "recognized", "and", "appropriately", "treated", "by", "understanding", "the", "physiological", "changes", "and", "clinical", "circumstances", "which", "put", "the", "elderly", "person", "at", "increased", "risk", "for", "deranged", "water", "and", "sodium", "balance", "." ]	[ "umlsterm" ]
body composition is an umlsterm, thirst is an umlsterm, perception is an umlsterm, function is an umlsterm, regulatory is an umlsterm, maintenance is an umlsterm, water is an umlsterm, sodium is an umlsterm, balance is an umlsterm, diseases is an umlsterm, drugs is an umlsterm, elderly is an umlsterm, water is an umlsterm, sodium is an umlsterm, symptoms is an umlsterm, morbidity is an umlsterm, mortality is an umlsterm, disorders is an umlsterm, dehydration is an umlsterm, hypernatremia is an umlsterm, hyponatremia is an umlsterm, frequency is an umlsterm, urinary incontinence is an umlsterm, elderly is an umlsterm, person is an umlsterm, risk is an umlsterm, water is an umlsterm, sodium is an umlsterm, balance is an umlsterm	ZfuerGerontologie+Geriatrie.9032s020.eng.abstr_task1	Sentence: Normal aging is associated with changes in body composition , thirst perception , renal function , and the hormonal regulatory systems involved in the maintenance of water and sodium balance . The presence of many diseases and drugs common in the elderly can interact with the impaired homeostatic systems to result in clinically significant disturbances of water and sodium with accompanying symptoms , morbidity , and mortality . These disorders , which include dehydration , hypernatremia , hyponatremia , urinary frequency , and urinary incontinence can either be prevented or promptly recognized and appropriately treated by understanding the physiological changes and clinical circumstances which put the elderly person at increased risk for deranged water and sodium balance . Instructions: please typing these entity words according to sentence: body composition, thirst, perception, function, regulatory, maintenance, water, sodium, balance, diseases, drugs, elderly, water, sodium, symptoms, morbidity, mortality, disorders, dehydration, hypernatremia, hyponatremia, frequency, urinary incontinence, elderly, person, risk, water, sodium, balance Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O" ]	Normal aging is associated with changes in body composition , thirst perception , renal function , and the hormonal regulatory systems involved in the maintenance of water and sodium balance . The presence of many diseases and drugs common in the elderly can interact with the impaired homeostatic systems to result in clinically significant disturbances of water and sodium with accompanying symptoms , morbidity , and mortality . These disorders , which include dehydration , hypernatremia , hyponatremia , urinary frequency , and urinary incontinence can either be prevented or promptly recognized and appropriately treated by understanding the physiological changes and clinical circumstances which put the elderly person at increased risk for deranged water and sodium balance .	[ "Normal", "aging", "is", "associated", "with", "changes", "in", "body", "composition", ",", "thirst", "perception", ",", "renal", "function", ",", "and", "the", "hormonal", "regulatory", "systems", "involved", "in", "the", "maintenance", "of", "water", "and", "sodium", "balance", ".", "The", "presence", "of", "many", "diseases", "and", "drugs", "common", "in", "the", "elderly", "can", "interact", "with", "the", "impaired", "homeostatic", "systems", "to", "result", "in", "clinically", "significant", "disturbances", "of", "water", "and", "sodium", "with", "accompanying", "symptoms", ",", "morbidity", ",", "and", "mortality", ".", "These", "disorders", ",", "which", "include", "dehydration", ",", "hypernatremia", ",", "hyponatremia", ",", "urinary", "frequency", ",", "and", "urinary", "incontinence", "can", "either", "be", "prevented", "or", "promptly", "recognized", "and", "appropriately", "treated", "by", "understanding", "the", "physiological", "changes", "and", "clinical", "circumstances", "which", "put", "the", "elderly", "person", "at", "increased", "risk", "for", "deranged", "water", "and", "sodium", "balance", "." ]	[ "umlsterm" ]
body composition, thirst, perception, function, regulatory, maintenance, water, sodium, balance, diseases, drugs, elderly, water, sodium, symptoms, morbidity, mortality, disorders, dehydration, hypernatremia, hyponatremia, frequency, urinary incontinence, elderly, person, risk, water, sodium, balance	ZfuerGerontologie+Geriatrie.9032s020.eng.abstr_task2	Sentence: Normal aging is associated with changes in body composition , thirst perception , renal function , and the hormonal regulatory systems involved in the maintenance of water and sodium balance . The presence of many diseases and drugs common in the elderly can interact with the impaired homeostatic systems to result in clinically significant disturbances of water and sodium with accompanying symptoms , morbidity , and mortality . These disorders , which include dehydration , hypernatremia , hyponatremia , urinary frequency , and urinary incontinence can either be prevented or promptly recognized and appropriately treated by understanding the physiological changes and clinical circumstances which put the elderly person at increased risk for deranged water and sodium balance . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O" ]	Normal aging is associated with changes in body composition , thirst perception , renal function , and the hormonal regulatory systems involved in the maintenance of water and sodium balance . The presence of many diseases and drugs common in the elderly can interact with the impaired homeostatic systems to result in clinically significant disturbances of water and sodium with accompanying symptoms , morbidity , and mortality . These disorders , which include dehydration , hypernatremia , hyponatremia , urinary frequency , and urinary incontinence can either be prevented or promptly recognized and appropriately treated by understanding the physiological changes and clinical circumstances which put the elderly person at increased risk for deranged water and sodium balance .	[ "Normal", "aging", "is", "associated", "with", "changes", "in", "body", "composition", ",", "thirst", "perception", ",", "renal", "function", ",", "and", "the", "hormonal", "regulatory", "systems", "involved", "in", "the", "maintenance", "of", "water", "and", "sodium", "balance", ".", "The", "presence", "of", "many", "diseases", "and", "drugs", "common", "in", "the", "elderly", "can", "interact", "with", "the", "impaired", "homeostatic", "systems", "to", "result", "in", "clinically", "significant", "disturbances", "of", "water", "and", "sodium", "with", "accompanying", "symptoms", ",", "morbidity", ",", "and", "mortality", ".", "These", "disorders", ",", "which", "include", "dehydration", ",", "hypernatremia", ",", "hyponatremia", ",", "urinary", "frequency", ",", "and", "urinary", "incontinence", "can", "either", "be", "prevented", "or", "promptly", "recognized", "and", "appropriately", "treated", "by", "understanding", "the", "physiological", "changes", "and", "clinical", "circumstances", "which", "put", "the", "elderly", "person", "at", "increased", "risk", "for", "deranged", "water", "and", "sodium", "balance", "." ]	[ "umlsterm" ]
dTAFII110 is a protein, GST - IIAτ is a fusion-protein, GST - αβ is a fusion-protein	1.0alpha7.train.271_task0	Sentence: Interestingly, dTAFII110 also bound GST-IIAτ more abundantly than it bound to GST-αβ (Fig.4 C, lane 4). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: fusion-protein, protein	[ "O", "O", "B-protein", "O", "O", "B-fusion-protein", "I-fusion-protein", "I-fusion-protein", "O", "O", "O", "O", "O", "O", "B-fusion-protein", "I-fusion-protein", "I-fusion-protein", "O", "O", "O", "O", "O", "O", "O", "O" ]	Interestingly, dTAFII110 also bound GST-IIAτ more abundantly than it bound to GST-αβ (Fig.4 C, lane 4).	[ "Interestingly", ",", "dTAFII110", "also", "bound", "GST", "-", "IIAτ", "more", "abundantly", "than", "it", "bound", "to", "GST", "-", "αβ", "(", "Fig.4", "C", ",", "lane", "4", ")", "." ]	[ "protein", "fusion-protein", "experiment-tag" ]
dTAFII110 is a protein, GST - IIAτ is a fusion-protein, GST - αβ is a fusion-protein	1.0alpha7.train.271_task1	Sentence: Interestingly, dTAFII110 also bound GST-IIAτ more abundantly than it bound to GST-αβ (Fig.4 C, lane 4). Instructions: please typing these entity words according to sentence: dTAFII110, GST - IIAτ, GST - αβ Options: fusion-protein, protein	[ "O", "O", "B-protein", "O", "O", "B-fusion-protein", "I-fusion-protein", "I-fusion-protein", "O", "O", "O", "O", "O", "O", "B-fusion-protein", "I-fusion-protein", "I-fusion-protein", "O", "O", "O", "O", "O", "O", "O", "O" ]	Interestingly, dTAFII110 also bound GST-IIAτ more abundantly than it bound to GST-αβ (Fig.4 C, lane 4).	[ "Interestingly", ",", "dTAFII110", "also", "bound", "GST", "-", "IIAτ", "more", "abundantly", "than", "it", "bound", "to", "GST", "-", "αβ", "(", "Fig.4", "C", ",", "lane", "4", ")", "." ]	[ "protein", "fusion-protein", "experiment-tag" ]
dTAFII110, GST - IIAτ, GST - αβ	1.0alpha7.train.271_task2	Sentence: Interestingly, dTAFII110 also bound GST-IIAτ more abundantly than it bound to GST-αβ (Fig.4 C, lane 4). Instructions: please extract entity words from the input sentence	[ "O", "O", "B-protein", "O", "O", "B-fusion-protein", "I-fusion-protein", "I-fusion-protein", "O", "O", "O", "O", "O", "O", "B-fusion-protein", "I-fusion-protein", "I-fusion-protein", "O", "O", "O", "O", "O", "O", "O", "O" ]	Interestingly, dTAFII110 also bound GST-IIAτ more abundantly than it bound to GST-αβ (Fig.4 C, lane 4).	[ "Interestingly", ",", "dTAFII110", "also", "bound", "GST", "-", "IIAτ", "more", "abundantly", "than", "it", "bound", "to", "GST", "-", "αβ", "(", "Fig.4", "C", ",", "lane", "4", ")", "." ]	[ "protein", "fusion-protein", "experiment-tag" ]
Arbeit is an umlsterm, chronischen Polyarthritis is an umlsterm, Gelenkdestruktion is an umlsterm, Methode is an umlsterm, Europa is an umlsterm, Standardreferenzfilmen is an umlsterm, Gelenkoberflaeche is an umlsterm, gelenknahe is an umlsterm, Osteoporose is an umlsterm, Originalmethode is an umlsterm, Gelenkoberflaeche is an umlsterm, Gelenkoberflaeche is an umlsterm, Gelenkoberflaeche is an umlsterm, Gelenke is an umlsterm, Haende is an umlsterm, Standardreferenzfilmen is an umlsterm, Fingergrund- is an umlsterm, Fingermittel- is an umlsterm, Handgelenke is an umlsterm, Zehengrundgelenke is an umlsterm, Methode is an umlsterm, Haende is an umlsterm, Patienten is an umlsterm, chronischer Polyarthritis is an umlsterm, Patienten is an umlsterm, Varianzanalyse is an umlsterm, ANOVA is an umlsterm, Methode is an umlsterm, Methode is an umlsterm, Patienten is an umlsterm, Basistherapiestudie is an umlsterm, Roentgenaufnahmen is an umlsterm, Therapiebeginn is an umlsterm, Verzoegerung is an umlsterm, radiologischen is an umlsterm, Gold is an umlsterm, Methotrexat is an umlsterm, radiologischen is an umlsterm, chronischen Polyarthritis is an umlsterm, Methode is an umlsterm	ZfuerRheumatologie.70560127.ger.abstr_task0	Sentence: Ziel der Arbeit : Entwicklung und Evaluation einer Modifikation der Larsen-Methode zur quantitativen Beschreibung des roentgenologischen Verlaufs der chronischen Polyarthritis mit dem Ziel einer eindeutigen verbalen Definition der verschiedenen Stadien und einer besseren Korrelation der numerischen Skala mit dem Ausmass der Gelenkdestruktion . Beschreibung der Methode : Waehrend die in Europa haeufig verwendete Original-Larsen-Methode im wesentlichen auf dem Vergleich der Roentgenbilder mit Standardreferenzfilmen bei nur vager verbaler Definition beruht , werden in der Modifikation die verschiedenen Stadien auch verbal durch semiquantitative Angabe des Ausmasses der Destruktion der Gelenkoberflaeche definiert : das StadiumI ist durch Weichteilschwellung und ggf. gelenknahe Osteoporose bzw. auch Gelenkspaltverschmaelerung charakterisiert und bleibt damit gegenueber der Originalmethode unveraendert ; das Stadium II entspricht einer Destruktion der Gelenkoberflaeche bis zu 25% der gesamten Gelenkoberflaeche , im StadiumIII sind 26-50% , im Stadium IV 51-75% und im StadiumV ueber 75% der Gelenkoberflaeche destruiert . 32 Gelenke der Haende und Vorfuesse werden bewertet , so dass sich ein Gesamtscore von 0-160 ergibt . Bespiele fuer die verschiedenen Stadien im Sinne von Standardreferenzfilmen fuer die Fingergrund- , Fingermittel- und Handgelenke sowie die Zehengrundgelenke werden gezeigt . Evaluation der Methode : Standard-ap-Aufnahmen der Haende und Vorfuesse von 24 Patienten mit frueher erosiver chronischer Polyarthritis ( c.P. ) zum Zeitpunkt 0 ( T0) und nach 36 Monaten ( T1) wurden von zwei Untersuchern ( G.H. und R.R. ) bewertet . Der Unterschied der Bewertung zwischen den beiden Untersuchern ( Inter-Observer-Differenz ) wurde mit dem Unterschied zwischen den beiden Zeitpunkten ( T0 und T1) beim gleichen Patienten ( Intra-Patienten-Differenz ) mittels einer hierarchischen Varianzanalyse ( ANOVA ) verglichen . Dabei erwies sich die Intrapatientenvarianz ( von T0 nach T1) als 8 mal groesser als die Varianz zwischen den Untersuchern . Der mit der Methode gefundene Unterschied zwischen beiden Beobachtungszeitpunkten ist also real und nicht durch Unsicherheit bei der Bewertung bedingt . - Zusaetzlich wurde die Methode bei Patienten einer zweijaehrigen Basistherapiestudie mit Roentgenaufnahmen zu Therapiebeginn sowie nach 6 , 12 und 24 Monaten angewandt . Dabei konnte eine Verzoegerung der radiologischen Progression nach dem sechsten Monat durch parenterales Gold und Methotrexat demonstriert werden . Schlussfolgerung : Die Modifikation der Larsen-Methode erweist sich als zuverlaessiges Mass zur Beschreibung des radiologischen Verlaufs der chronischen Polyarthritis . Weitere Verbesserungsmoeglichkeiten der Methode werden diskutiert . 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Beschreibung der Methode : Waehrend die in Europa haeufig verwendete Original-Larsen-Methode im wesentlichen auf dem Vergleich der Roentgenbilder mit Standardreferenzfilmen bei nur vager verbaler Definition beruht , werden in der Modifikation die verschiedenen Stadien auch verbal durch semiquantitative Angabe des Ausmasses der Destruktion der Gelenkoberflaeche definiert : das StadiumI ist durch Weichteilschwellung und ggf. gelenknahe Osteoporose bzw. auch Gelenkspaltverschmaelerung charakterisiert und bleibt damit gegenueber der Originalmethode unveraendert ; das Stadium II entspricht einer Destruktion der Gelenkoberflaeche bis zu 25% der gesamten Gelenkoberflaeche , im StadiumIII sind 26-50% , im Stadium IV 51-75% und im StadiumV ueber 75% der Gelenkoberflaeche destruiert . 32 Gelenke der Haende und Vorfuesse werden bewertet , so dass sich ein Gesamtscore von 0-160 ergibt . Bespiele fuer die verschiedenen Stadien im Sinne von Standardreferenzfilmen fuer die Fingergrund- , Fingermittel- und Handgelenke sowie die Zehengrundgelenke werden gezeigt . Evaluation der Methode : Standard-ap-Aufnahmen der Haende und Vorfuesse von 24 Patienten mit frueher erosiver chronischer Polyarthritis ( c.P. ) zum Zeitpunkt 0 ( T0) und nach 36 Monaten ( T1) wurden von zwei Untersuchern ( G.H. und R.R. ) bewertet . Der Unterschied der Bewertung zwischen den beiden Untersuchern ( Inter-Observer-Differenz ) wurde mit dem Unterschied zwischen den beiden Zeitpunkten ( T0 und T1) beim gleichen Patienten ( Intra-Patienten-Differenz ) mittels einer hierarchischen Varianzanalyse ( ANOVA ) verglichen . Dabei erwies sich die Intrapatientenvarianz ( von T0 nach T1) als 8 mal groesser als die Varianz zwischen den Untersuchern . Der mit der Methode gefundene Unterschied zwischen beiden Beobachtungszeitpunkten ist also real und nicht durch Unsicherheit bei der Bewertung bedingt . - Zusaetzlich wurde die Methode bei Patienten einer zweijaehrigen Basistherapiestudie mit Roentgenaufnahmen zu Therapiebeginn sowie nach 6 , 12 und 24 Monaten angewandt . Dabei konnte eine Verzoegerung der radiologischen Progression nach dem sechsten Monat durch parenterales Gold und Methotrexat demonstriert werden . Schlussfolgerung : Die Modifikation der Larsen-Methode erweist sich als zuverlaessiges Mass zur Beschreibung des radiologischen Verlaufs der chronischen Polyarthritis . Weitere Verbesserungsmoeglichkeiten der Methode werden diskutiert .	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Arbeit is an umlsterm, chronischen Polyarthritis is an umlsterm, Gelenkdestruktion is an umlsterm, Methode is an umlsterm, Europa is an umlsterm, Standardreferenzfilmen is an umlsterm, Gelenkoberflaeche is an umlsterm, gelenknahe is an umlsterm, Osteoporose is an umlsterm, Originalmethode is an umlsterm, Gelenkoberflaeche is an umlsterm, Gelenkoberflaeche is an umlsterm, Gelenkoberflaeche is an umlsterm, Gelenke is an umlsterm, Haende is an umlsterm, Standardreferenzfilmen is an umlsterm, Fingergrund- is an umlsterm, Fingermittel- is an umlsterm, Handgelenke is an umlsterm, Zehengrundgelenke is an umlsterm, Methode is an umlsterm, Haende is an umlsterm, Patienten is an umlsterm, chronischer Polyarthritis is an umlsterm, Patienten is an umlsterm, Varianzanalyse is an umlsterm, ANOVA is an umlsterm, Methode is an umlsterm, Methode is an umlsterm, Patienten is an umlsterm, Basistherapiestudie is an umlsterm, Roentgenaufnahmen is an umlsterm, Therapiebeginn is an umlsterm, Verzoegerung is an umlsterm, radiologischen is an umlsterm, Gold is an umlsterm, Methotrexat is an umlsterm, radiologischen is an umlsterm, chronischen Polyarthritis is an umlsterm, Methode is an umlsterm	ZfuerRheumatologie.70560127.ger.abstr_task1	Sentence: Ziel der Arbeit : Entwicklung und Evaluation einer Modifikation der Larsen-Methode zur quantitativen Beschreibung des roentgenologischen Verlaufs der chronischen Polyarthritis mit dem Ziel einer eindeutigen verbalen Definition der verschiedenen Stadien und einer besseren Korrelation der numerischen Skala mit dem Ausmass der Gelenkdestruktion . Beschreibung der Methode : Waehrend die in Europa haeufig verwendete Original-Larsen-Methode im wesentlichen auf dem Vergleich der Roentgenbilder mit Standardreferenzfilmen bei nur vager verbaler Definition beruht , werden in der Modifikation die verschiedenen Stadien auch verbal durch semiquantitative Angabe des Ausmasses der Destruktion der Gelenkoberflaeche definiert : das StadiumI ist durch Weichteilschwellung und ggf. gelenknahe Osteoporose bzw. auch Gelenkspaltverschmaelerung charakterisiert und bleibt damit gegenueber der Originalmethode unveraendert ; das Stadium II entspricht einer Destruktion der Gelenkoberflaeche bis zu 25% der gesamten Gelenkoberflaeche , im StadiumIII sind 26-50% , im Stadium IV 51-75% und im StadiumV ueber 75% der Gelenkoberflaeche destruiert . 32 Gelenke der Haende und Vorfuesse werden bewertet , so dass sich ein Gesamtscore von 0-160 ergibt . Bespiele fuer die verschiedenen Stadien im Sinne von Standardreferenzfilmen fuer die Fingergrund- , Fingermittel- und Handgelenke sowie die Zehengrundgelenke werden gezeigt . Evaluation der Methode : Standard-ap-Aufnahmen der Haende und Vorfuesse von 24 Patienten mit frueher erosiver chronischer Polyarthritis ( c.P. ) zum Zeitpunkt 0 ( T0) und nach 36 Monaten ( T1) wurden von zwei Untersuchern ( G.H. und R.R. ) bewertet . Der Unterschied der Bewertung zwischen den beiden Untersuchern ( Inter-Observer-Differenz ) wurde mit dem Unterschied zwischen den beiden Zeitpunkten ( T0 und T1) beim gleichen Patienten ( Intra-Patienten-Differenz ) mittels einer hierarchischen Varianzanalyse ( ANOVA ) verglichen . Dabei erwies sich die Intrapatientenvarianz ( von T0 nach T1) als 8 mal groesser als die Varianz zwischen den Untersuchern . Der mit der Methode gefundene Unterschied zwischen beiden Beobachtungszeitpunkten ist also real und nicht durch Unsicherheit bei der Bewertung bedingt . - Zusaetzlich wurde die Methode bei Patienten einer zweijaehrigen Basistherapiestudie mit Roentgenaufnahmen zu Therapiebeginn sowie nach 6 , 12 und 24 Monaten angewandt . Dabei konnte eine Verzoegerung der radiologischen Progression nach dem sechsten Monat durch parenterales Gold und Methotrexat demonstriert werden . Schlussfolgerung : Die Modifikation der Larsen-Methode erweist sich als zuverlaessiges Mass zur Beschreibung des radiologischen Verlaufs der chronischen Polyarthritis . Weitere Verbesserungsmoeglichkeiten der Methode werden diskutiert . 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Beschreibung der Methode : Waehrend die in Europa haeufig verwendete Original-Larsen-Methode im wesentlichen auf dem Vergleich der Roentgenbilder mit Standardreferenzfilmen bei nur vager verbaler Definition beruht , werden in der Modifikation die verschiedenen Stadien auch verbal durch semiquantitative Angabe des Ausmasses der Destruktion der Gelenkoberflaeche definiert : das StadiumI ist durch Weichteilschwellung und ggf. gelenknahe Osteoporose bzw. auch Gelenkspaltverschmaelerung charakterisiert und bleibt damit gegenueber der Originalmethode unveraendert ; das Stadium II entspricht einer Destruktion der Gelenkoberflaeche bis zu 25% der gesamten Gelenkoberflaeche , im StadiumIII sind 26-50% , im Stadium IV 51-75% und im StadiumV ueber 75% der Gelenkoberflaeche destruiert . 32 Gelenke der Haende und Vorfuesse werden bewertet , so dass sich ein Gesamtscore von 0-160 ergibt . Bespiele fuer die verschiedenen Stadien im Sinne von Standardreferenzfilmen fuer die Fingergrund- , Fingermittel- und Handgelenke sowie die Zehengrundgelenke werden gezeigt . Evaluation der Methode : Standard-ap-Aufnahmen der Haende und Vorfuesse von 24 Patienten mit frueher erosiver chronischer Polyarthritis ( c.P. ) zum Zeitpunkt 0 ( T0) und nach 36 Monaten ( T1) wurden von zwei Untersuchern ( G.H. und R.R. ) bewertet . Der Unterschied der Bewertung zwischen den beiden Untersuchern ( Inter-Observer-Differenz ) wurde mit dem Unterschied zwischen den beiden Zeitpunkten ( T0 und T1) beim gleichen Patienten ( Intra-Patienten-Differenz ) mittels einer hierarchischen Varianzanalyse ( ANOVA ) verglichen . Dabei erwies sich die Intrapatientenvarianz ( von T0 nach T1) als 8 mal groesser als die Varianz zwischen den Untersuchern . Der mit der Methode gefundene Unterschied zwischen beiden Beobachtungszeitpunkten ist also real und nicht durch Unsicherheit bei der Bewertung bedingt . - Zusaetzlich wurde die Methode bei Patienten einer zweijaehrigen Basistherapiestudie mit Roentgenaufnahmen zu Therapiebeginn sowie nach 6 , 12 und 24 Monaten angewandt . Dabei konnte eine Verzoegerung der radiologischen Progression nach dem sechsten Monat durch parenterales Gold und Methotrexat demonstriert werden . Schlussfolgerung : Die Modifikation der Larsen-Methode erweist sich als zuverlaessiges Mass zur Beschreibung des radiologischen Verlaufs der chronischen Polyarthritis . Weitere Verbesserungsmoeglichkeiten der Methode werden diskutiert .	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Arbeit, chronischen Polyarthritis, Gelenkdestruktion, Methode, Europa, Standardreferenzfilmen, Gelenkoberflaeche, gelenknahe, Osteoporose, Originalmethode, Gelenkoberflaeche, Gelenkoberflaeche, Gelenkoberflaeche, Gelenke, Haende, Standardreferenzfilmen, Fingergrund-, Fingermittel-, Handgelenke, Zehengrundgelenke, Methode, Haende, Patienten, chronischer Polyarthritis, Patienten, Varianzanalyse, ANOVA, Methode, Methode, Patienten, Basistherapiestudie, Roentgenaufnahmen, Therapiebeginn, Verzoegerung, radiologischen, Gold, Methotrexat, radiologischen, chronischen Polyarthritis, Methode	ZfuerRheumatologie.70560127.ger.abstr_task2	Sentence: Ziel der Arbeit : Entwicklung und Evaluation einer Modifikation der Larsen-Methode zur quantitativen Beschreibung des roentgenologischen Verlaufs der chronischen Polyarthritis mit dem Ziel einer eindeutigen verbalen Definition der verschiedenen Stadien und einer besseren Korrelation der numerischen Skala mit dem Ausmass der Gelenkdestruktion . Beschreibung der Methode : Waehrend die in Europa haeufig verwendete Original-Larsen-Methode im wesentlichen auf dem Vergleich der Roentgenbilder mit Standardreferenzfilmen bei nur vager verbaler Definition beruht , werden in der Modifikation die verschiedenen Stadien auch verbal durch semiquantitative Angabe des Ausmasses der Destruktion der Gelenkoberflaeche definiert : das StadiumI ist durch Weichteilschwellung und ggf. gelenknahe Osteoporose bzw. auch Gelenkspaltverschmaelerung charakterisiert und bleibt damit gegenueber der Originalmethode unveraendert ; das Stadium II entspricht einer Destruktion der Gelenkoberflaeche bis zu 25% der gesamten Gelenkoberflaeche , im StadiumIII sind 26-50% , im Stadium IV 51-75% und im StadiumV ueber 75% der Gelenkoberflaeche destruiert . 32 Gelenke der Haende und Vorfuesse werden bewertet , so dass sich ein Gesamtscore von 0-160 ergibt . Bespiele fuer die verschiedenen Stadien im Sinne von Standardreferenzfilmen fuer die Fingergrund- , Fingermittel- und Handgelenke sowie die Zehengrundgelenke werden gezeigt . Evaluation der Methode : Standard-ap-Aufnahmen der Haende und Vorfuesse von 24 Patienten mit frueher erosiver chronischer Polyarthritis ( c.P. ) zum Zeitpunkt 0 ( T0) und nach 36 Monaten ( T1) wurden von zwei Untersuchern ( G.H. und R.R. ) bewertet . Der Unterschied der Bewertung zwischen den beiden Untersuchern ( Inter-Observer-Differenz ) wurde mit dem Unterschied zwischen den beiden Zeitpunkten ( T0 und T1) beim gleichen Patienten ( Intra-Patienten-Differenz ) mittels einer hierarchischen Varianzanalyse ( ANOVA ) verglichen . Dabei erwies sich die Intrapatientenvarianz ( von T0 nach T1) als 8 mal groesser als die Varianz zwischen den Untersuchern . Der mit der Methode gefundene Unterschied zwischen beiden Beobachtungszeitpunkten ist also real und nicht durch Unsicherheit bei der Bewertung bedingt . - Zusaetzlich wurde die Methode bei Patienten einer zweijaehrigen Basistherapiestudie mit Roentgenaufnahmen zu Therapiebeginn sowie nach 6 , 12 und 24 Monaten angewandt . Dabei konnte eine Verzoegerung der radiologischen Progression nach dem sechsten Monat durch parenterales Gold und Methotrexat demonstriert werden . Schlussfolgerung : Die Modifikation der Larsen-Methode erweist sich als zuverlaessiges Mass zur Beschreibung des radiologischen Verlaufs der chronischen Polyarthritis . Weitere Verbesserungsmoeglichkeiten der Methode werden diskutiert . 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Beschreibung der Methode : Waehrend die in Europa haeufig verwendete Original-Larsen-Methode im wesentlichen auf dem Vergleich der Roentgenbilder mit Standardreferenzfilmen bei nur vager verbaler Definition beruht , werden in der Modifikation die verschiedenen Stadien auch verbal durch semiquantitative Angabe des Ausmasses der Destruktion der Gelenkoberflaeche definiert : das StadiumI ist durch Weichteilschwellung und ggf. gelenknahe Osteoporose bzw. auch Gelenkspaltverschmaelerung charakterisiert und bleibt damit gegenueber der Originalmethode unveraendert ; das Stadium II entspricht einer Destruktion der Gelenkoberflaeche bis zu 25% der gesamten Gelenkoberflaeche , im StadiumIII sind 26-50% , im Stadium IV 51-75% und im StadiumV ueber 75% der Gelenkoberflaeche destruiert . 32 Gelenke der Haende und Vorfuesse werden bewertet , so dass sich ein Gesamtscore von 0-160 ergibt . Bespiele fuer die verschiedenen Stadien im Sinne von Standardreferenzfilmen fuer die Fingergrund- , Fingermittel- und Handgelenke sowie die Zehengrundgelenke werden gezeigt . Evaluation der Methode : Standard-ap-Aufnahmen der Haende und Vorfuesse von 24 Patienten mit frueher erosiver chronischer Polyarthritis ( c.P. ) zum Zeitpunkt 0 ( T0) und nach 36 Monaten ( T1) wurden von zwei Untersuchern ( G.H. und R.R. ) bewertet . Der Unterschied der Bewertung zwischen den beiden Untersuchern ( Inter-Observer-Differenz ) wurde mit dem Unterschied zwischen den beiden Zeitpunkten ( T0 und T1) beim gleichen Patienten ( Intra-Patienten-Differenz ) mittels einer hierarchischen Varianzanalyse ( ANOVA ) verglichen . Dabei erwies sich die Intrapatientenvarianz ( von T0 nach T1) als 8 mal groesser als die Varianz zwischen den Untersuchern . Der mit der Methode gefundene Unterschied zwischen beiden Beobachtungszeitpunkten ist also real und nicht durch Unsicherheit bei der Bewertung bedingt . - Zusaetzlich wurde die Methode bei Patienten einer zweijaehrigen Basistherapiestudie mit Roentgenaufnahmen zu Therapiebeginn sowie nach 6 , 12 und 24 Monaten angewandt . Dabei konnte eine Verzoegerung der radiologischen Progression nach dem sechsten Monat durch parenterales Gold und Methotrexat demonstriert werden . Schlussfolgerung : Die Modifikation der Larsen-Methode erweist sich als zuverlaessiges Mass zur Beschreibung des radiologischen Verlaufs der chronischen Polyarthritis . Weitere Verbesserungsmoeglichkeiten der Methode werden diskutiert .	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dilatation is an umlsterm, maxilla is an umlsterm, conservative - surgical is an umlsterm, method is an umlsterm, anterior is an umlsterm, maxilla is an umlsterm, apparatus is an umlsterm, dilatation is an umlsterm, maxilla is an umlsterm, period is an umlsterm, patients is an umlsterm, findings is an umlsterm, method is an umlsterm, maxilla is an umlsterm, apparatus is an umlsterm, method is an umlsterm, dilatation is an umlsterm, dilatation is an umlsterm, maxilla is an umlsterm, mono- is an umlsterm, operation is an umlsterm, use is an umlsterm, method is an umlsterm, patients is an umlsterm, Dilatation is an umlsterm, maxilla is an umlsterm, postoperative is an umlsterm, anterior is an umlsterm, posterior is an umlsterm, dental arch is an umlsterm, X - ray is an umlsterm, maxilla is an umlsterm, patient is an umlsterm, age is an umlsterm, fracture is an umlsterm, alveolar process is an umlsterm, maxilla is an umlsterm, method is an umlsterm, dilatation is an umlsterm, maxilla is an umlsterm, patients is an umlsterm, age is an umlsterm, older is an umlsterm, patients is an umlsterm	MundKieferGesichtschirurgie.80020026.eng.abstr_task0	Sentence: The median palatine suture has long been regarded as having the greatest resistance to dilatation of the maxilla . In 1984 Glassman [ 3 ] presented a conservative-surgical method of division of the palatineal suture in which only the lateral and anterior support of the maxilla is debilitated surgically . An orthodontic apparatus cemented in place preoperatively is already used intraoperatively for dilatation of the maxilla . In the period from 1991 to 1997 , 16 patients with a leptomaxilla and various dysnathic findings have been operated on at our clinic by the method described by Glassman [ 3 ] . Sometimes the maxilla was dilated intraoperatively using the apparatus cemented in place by the method of Derichsweiler and dilatation was continued postoperatively until the described result was achieved . After successful dilatation of the maxilla and a stabilizing phase , a mono- or bimaxillary operation was performed . The use of this method led to the desired result in 15 patients . Dilatation of the maxilla was objectivized by determining the pre- and postoperative width of the anterior and posterior dental arch using models and X-ray of the occlusal overlay of the maxilla . In one patient who was operated on at the age of 38 years , a fracture of the alveolar process of the maxilla occurred unilaterally due to the completed ossification of the median palatine suture . The method of surgically aided dilatation of the maxilla at the level of Le Fort I plane is suitable for patients up to the age of 30. In older patients , the median palatine suture should be transsected as well . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The median palatine suture has long been regarded as having the greatest resistance to dilatation of the maxilla . In 1984 Glassman [ 3 ] presented a conservative-surgical method of division of the palatineal suture in which only the lateral and anterior support of the maxilla is debilitated surgically . An orthodontic apparatus cemented in place preoperatively is already used intraoperatively for dilatation of the maxilla . In the period from 1991 to 1997 , 16 patients with a leptomaxilla and various dysnathic findings have been operated on at our clinic by the method described by Glassman [ 3 ] . Sometimes the maxilla was dilated intraoperatively using the apparatus cemented in place by the method of Derichsweiler and dilatation was continued postoperatively until the described result was achieved . After successful dilatation of the maxilla and a stabilizing phase , a mono- or bimaxillary operation was performed . The use of this method led to the desired result in 15 patients . Dilatation of the maxilla was objectivized by determining the pre- and postoperative width of the anterior and posterior dental arch using models and X-ray of the occlusal overlay of the maxilla . In one patient who was operated on at the age of 38 years , a fracture of the alveolar process of the maxilla occurred unilaterally due to the completed ossification of the median palatine suture . The method of surgically aided dilatation of the maxilla at the level of Le Fort I plane is suitable for patients up to the age of 30. In older patients , the median palatine suture should be transsected as well .	[ "The", "median", "palatine", "suture", "has", "long", "been", "regarded", "as", "having", "the", "greatest", "resistance", "to", "dilatation", "of", "the", "maxilla", ".", "In", "1984", "Glassman", "[", "3", "]", "presented", "a", "conservative", "-", "surgical", "method", "of", "division", "of", "the", "palatineal", "suture", "in", "which", "only", "the", "lateral", "and", "anterior", "support", "of", "the", "maxilla", "is", "debilitated", "surgically", ".", "An", "orthodontic", "apparatus", "cemented", "in", "place", "preoperatively", "is", "already", "used", "intraoperatively", "for", "dilatation", "of", "the", "maxilla", ".", "In", "the", "period", "from", "1991", "to", "1997", ",", "16", "patients", "with", "a", "leptomaxilla", "and", "various", "dysnathic", "findings", "have", "been", "operated", "on", "at", "our", "clinic", "by", "the", "method", "described", "by", "Glassman", "[", "3", "]", ".", "Sometimes", "the", "maxilla", "was", "dilated", "intraoperatively", "using", "the", "apparatus", "cemented", "in", "place", "by", "the", "method", "of", "Derichsweiler", "and", "dilatation", "was", "continued", "postoperatively", "until", "the", "described", "result", "was", "achieved", ".", "After", "successful", "dilatation", "of", "the", "maxilla", "and", "a", "stabilizing", "phase", ",", "a", "mono-", "or", "bimaxillary", "operation", "was", "performed", ".", "The", "use", "of", "this", "method", "led", "to", "the", "desired", "result", "in", "15", "patients", ".", "Dilatation", "of", "the", "maxilla", "was", "objectivized", "by", "determining", "the", "pre-", "and", "postoperative", "width", "of", "the", "anterior", "and", "posterior", "dental", "arch", "using", "models", "and", "X", "-", "ray", "of", "the", "occlusal", "overlay", "of", "the", "maxilla", ".", "In", "one", "patient", "who", "was", "operated", "on", "at", "the", "age", "of", "38", "years", ",", "a", "fracture", "of", "the", "alveolar", "process", "of", "the", "maxilla", "occurred", "unilaterally", "due", "to", "the", "completed", "ossification", "of", "the", "median", "palatine", "suture", ".", "The", "method", "of", "surgically", "aided", "dilatation", "of", "the", "maxilla", "at", "the", "level", "of", "Le", "Fort", "I", "plane", "is", "suitable", "for", "patients", "up", "to", "the", "age", "of", "30", ".", "In", "older", "patients", ",", "the", "median", "palatine", "suture", "should", "be", "transsected", "as", "well", "." ]	[ "umlsterm" ]
dilatation is an umlsterm, maxilla is an umlsterm, conservative - surgical is an umlsterm, method is an umlsterm, anterior is an umlsterm, maxilla is an umlsterm, apparatus is an umlsterm, dilatation is an umlsterm, maxilla is an umlsterm, period is an umlsterm, patients is an umlsterm, findings is an umlsterm, method is an umlsterm, maxilla is an umlsterm, apparatus is an umlsterm, method is an umlsterm, dilatation is an umlsterm, dilatation is an umlsterm, maxilla is an umlsterm, mono- is an umlsterm, operation is an umlsterm, use is an umlsterm, method is an umlsterm, patients is an umlsterm, Dilatation is an umlsterm, maxilla is an umlsterm, postoperative is an umlsterm, anterior is an umlsterm, posterior is an umlsterm, dental arch is an umlsterm, X - ray is an umlsterm, maxilla is an umlsterm, patient is an umlsterm, age is an umlsterm, fracture is an umlsterm, alveolar process is an umlsterm, maxilla is an umlsterm, method is an umlsterm, dilatation is an umlsterm, maxilla is an umlsterm, patients is an umlsterm, age is an umlsterm, older is an umlsterm, patients is an umlsterm	MundKieferGesichtschirurgie.80020026.eng.abstr_task1	Sentence: The median palatine suture has long been regarded as having the greatest resistance to dilatation of the maxilla . In 1984 Glassman [ 3 ] presented a conservative-surgical method of division of the palatineal suture in which only the lateral and anterior support of the maxilla is debilitated surgically . An orthodontic apparatus cemented in place preoperatively is already used intraoperatively for dilatation of the maxilla . In the period from 1991 to 1997 , 16 patients with a leptomaxilla and various dysnathic findings have been operated on at our clinic by the method described by Glassman [ 3 ] . Sometimes the maxilla was dilated intraoperatively using the apparatus cemented in place by the method of Derichsweiler and dilatation was continued postoperatively until the described result was achieved . After successful dilatation of the maxilla and a stabilizing phase , a mono- or bimaxillary operation was performed . The use of this method led to the desired result in 15 patients . Dilatation of the maxilla was objectivized by determining the pre- and postoperative width of the anterior and posterior dental arch using models and X-ray of the occlusal overlay of the maxilla . In one patient who was operated on at the age of 38 years , a fracture of the alveolar process of the maxilla occurred unilaterally due to the completed ossification of the median palatine suture . The method of surgically aided dilatation of the maxilla at the level of Le Fort I plane is suitable for patients up to the age of 30. In older patients , the median palatine suture should be transsected as well . Instructions: please typing these entity words according to sentence: dilatation, maxilla, conservative - surgical, method, anterior, maxilla, apparatus, dilatation, maxilla, period, patients, findings, method, maxilla, apparatus, method, dilatation, dilatation, maxilla, mono-, operation, use, method, patients, Dilatation, maxilla, postoperative, anterior, posterior, dental arch, X - ray, maxilla, patient, age, fracture, alveolar process, maxilla, method, dilatation, maxilla, patients, age, older, patients Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The median palatine suture has long been regarded as having the greatest resistance to dilatation of the maxilla . In 1984 Glassman [ 3 ] presented a conservative-surgical method of division of the palatineal suture in which only the lateral and anterior support of the maxilla is debilitated surgically . An orthodontic apparatus cemented in place preoperatively is already used intraoperatively for dilatation of the maxilla . In the period from 1991 to 1997 , 16 patients with a leptomaxilla and various dysnathic findings have been operated on at our clinic by the method described by Glassman [ 3 ] . Sometimes the maxilla was dilated intraoperatively using the apparatus cemented in place by the method of Derichsweiler and dilatation was continued postoperatively until the described result was achieved . After successful dilatation of the maxilla and a stabilizing phase , a mono- or bimaxillary operation was performed . The use of this method led to the desired result in 15 patients . Dilatation of the maxilla was objectivized by determining the pre- and postoperative width of the anterior and posterior dental arch using models and X-ray of the occlusal overlay of the maxilla . In one patient who was operated on at the age of 38 years , a fracture of the alveolar process of the maxilla occurred unilaterally due to the completed ossification of the median palatine suture . The method of surgically aided dilatation of the maxilla at the level of Le Fort I plane is suitable for patients up to the age of 30. In older patients , the median palatine suture should be transsected as well .	[ "The", "median", "palatine", "suture", "has", "long", "been", "regarded", "as", "having", "the", "greatest", "resistance", "to", "dilatation", "of", "the", "maxilla", ".", "In", "1984", "Glassman", "[", "3", "]", "presented", "a", "conservative", "-", "surgical", "method", "of", "division", "of", "the", "palatineal", "suture", "in", "which", "only", "the", "lateral", "and", "anterior", "support", "of", "the", "maxilla", "is", "debilitated", "surgically", ".", "An", "orthodontic", "apparatus", "cemented", "in", "place", "preoperatively", "is", "already", "used", "intraoperatively", "for", "dilatation", "of", "the", "maxilla", ".", "In", "the", "period", "from", "1991", "to", "1997", ",", "16", "patients", "with", "a", "leptomaxilla", "and", "various", "dysnathic", "findings", "have", "been", "operated", "on", "at", "our", "clinic", "by", "the", "method", "described", "by", "Glassman", "[", "3", "]", ".", "Sometimes", "the", "maxilla", "was", "dilated", "intraoperatively", "using", "the", "apparatus", "cemented", "in", "place", "by", "the", "method", "of", "Derichsweiler", "and", "dilatation", "was", "continued", "postoperatively", "until", "the", "described", "result", "was", "achieved", ".", "After", "successful", "dilatation", "of", "the", "maxilla", "and", "a", "stabilizing", "phase", ",", "a", "mono-", "or", "bimaxillary", "operation", "was", "performed", ".", "The", "use", "of", "this", "method", "led", "to", "the", "desired", "result", "in", "15", "patients", ".", "Dilatation", "of", "the", "maxilla", "was", "objectivized", "by", "determining", "the", "pre-", "and", "postoperative", "width", "of", "the", "anterior", "and", "posterior", "dental", "arch", "using", "models", "and", "X", "-", "ray", "of", "the", "occlusal", "overlay", "of", "the", "maxilla", ".", "In", "one", "patient", "who", "was", "operated", "on", "at", "the", "age", "of", "38", "years", ",", "a", "fracture", "of", "the", "alveolar", "process", "of", "the", "maxilla", "occurred", "unilaterally", "due", "to", "the", "completed", "ossification", "of", "the", "median", "palatine", "suture", ".", "The", "method", "of", "surgically", "aided", "dilatation", "of", "the", "maxilla", "at", "the", "level", "of", "Le", "Fort", "I", "plane", "is", "suitable", "for", "patients", "up", "to", "the", "age", "of", "30", ".", "In", "older", "patients", ",", "the", "median", "palatine", "suture", "should", "be", "transsected", "as", "well", "." ]	[ "umlsterm" ]
dilatation, maxilla, conservative - surgical, method, anterior, maxilla, apparatus, dilatation, maxilla, period, patients, findings, method, maxilla, apparatus, method, dilatation, dilatation, maxilla, mono-, operation, use, method, patients, Dilatation, maxilla, postoperative, anterior, posterior, dental arch, X - ray, maxilla, patient, age, fracture, alveolar process, maxilla, method, dilatation, maxilla, patients, age, older, patients	MundKieferGesichtschirurgie.80020026.eng.abstr_task2	Sentence: The median palatine suture has long been regarded as having the greatest resistance to dilatation of the maxilla . In 1984 Glassman [ 3 ] presented a conservative-surgical method of division of the palatineal suture in which only the lateral and anterior support of the maxilla is debilitated surgically . An orthodontic apparatus cemented in place preoperatively is already used intraoperatively for dilatation of the maxilla . In the period from 1991 to 1997 , 16 patients with a leptomaxilla and various dysnathic findings have been operated on at our clinic by the method described by Glassman [ 3 ] . Sometimes the maxilla was dilated intraoperatively using the apparatus cemented in place by the method of Derichsweiler and dilatation was continued postoperatively until the described result was achieved . After successful dilatation of the maxilla and a stabilizing phase , a mono- or bimaxillary operation was performed . The use of this method led to the desired result in 15 patients . Dilatation of the maxilla was objectivized by determining the pre- and postoperative width of the anterior and posterior dental arch using models and X-ray of the occlusal overlay of the maxilla . In one patient who was operated on at the age of 38 years , a fracture of the alveolar process of the maxilla occurred unilaterally due to the completed ossification of the median palatine suture . The method of surgically aided dilatation of the maxilla at the level of Le Fort I plane is suitable for patients up to the age of 30. In older patients , the median palatine suture should be transsected as well . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The median palatine suture has long been regarded as having the greatest resistance to dilatation of the maxilla . In 1984 Glassman [ 3 ] presented a conservative-surgical method of division of the palatineal suture in which only the lateral and anterior support of the maxilla is debilitated surgically . An orthodontic apparatus cemented in place preoperatively is already used intraoperatively for dilatation of the maxilla . In the period from 1991 to 1997 , 16 patients with a leptomaxilla and various dysnathic findings have been operated on at our clinic by the method described by Glassman [ 3 ] . Sometimes the maxilla was dilated intraoperatively using the apparatus cemented in place by the method of Derichsweiler and dilatation was continued postoperatively until the described result was achieved . After successful dilatation of the maxilla and a stabilizing phase , a mono- or bimaxillary operation was performed . The use of this method led to the desired result in 15 patients . Dilatation of the maxilla was objectivized by determining the pre- and postoperative width of the anterior and posterior dental arch using models and X-ray of the occlusal overlay of the maxilla . In one patient who was operated on at the age of 38 years , a fracture of the alveolar process of the maxilla occurred unilaterally due to the completed ossification of the median palatine suture . The method of surgically aided dilatation of the maxilla at the level of Le Fort I plane is suitable for patients up to the age of 30. In older patients , the median palatine suture should be transsected as well .	[ "The", "median", "palatine", "suture", "has", "long", "been", "regarded", "as", "having", "the", "greatest", "resistance", "to", "dilatation", "of", "the", "maxilla", ".", "In", "1984", "Glassman", "[", "3", "]", "presented", "a", "conservative", "-", "surgical", "method", "of", "division", "of", "the", "palatineal", "suture", "in", "which", "only", "the", "lateral", "and", "anterior", "support", "of", "the", "maxilla", "is", "debilitated", "surgically", ".", "An", "orthodontic", "apparatus", "cemented", "in", "place", "preoperatively", "is", "already", "used", "intraoperatively", "for", "dilatation", "of", "the", "maxilla", ".", "In", "the", "period", "from", "1991", "to", "1997", ",", "16", "patients", "with", "a", "leptomaxilla", "and", "various", "dysnathic", "findings", "have", "been", "operated", "on", "at", "our", "clinic", "by", "the", "method", "described", "by", "Glassman", "[", "3", "]", ".", "Sometimes", "the", "maxilla", "was", "dilated", "intraoperatively", "using", "the", "apparatus", "cemented", "in", "place", "by", "the", "method", "of", "Derichsweiler", "and", "dilatation", "was", "continued", "postoperatively", "until", "the", "described", "result", "was", "achieved", ".", "After", "successful", "dilatation", "of", "the", "maxilla", "and", "a", "stabilizing", "phase", ",", "a", "mono-", "or", "bimaxillary", "operation", "was", "performed", ".", "The", "use", "of", "this", "method", "led", "to", "the", "desired", "result", "in", "15", "patients", ".", "Dilatation", "of", "the", "maxilla", "was", "objectivized", "by", "determining", "the", "pre-", "and", "postoperative", "width", "of", "the", "anterior", "and", "posterior", "dental", "arch", "using", "models", "and", "X", "-", "ray", "of", "the", "occlusal", "overlay", "of", "the", "maxilla", ".", "In", "one", "patient", "who", "was", "operated", "on", "at", "the", "age", "of", "38", "years", ",", "a", "fracture", "of", "the", "alveolar", "process", "of", "the", "maxilla", "occurred", "unilaterally", "due", "to", "the", "completed", "ossification", "of", "the", "median", "palatine", "suture", ".", "The", "method", "of", "surgically", "aided", "dilatation", "of", "the", "maxilla", "at", "the", "level", "of", "Le", "Fort", "I", "plane", "is", "suitable", "for", "patients", "up", "to", "the", "age", "of", "30", ".", "In", "older", "patients", ",", "the", "median", "palatine", "suture", "should", "be", "transsected", "as", "well", "." ]	[ "umlsterm" ]
intercurrent infections is a Condition, sepsis is a Condition, drugs affecting immune system is a Drug, immunosuppressive drugs is a Drug, antibiotics is a Drug	NCT03539718_exc_task0	Sentence: Patients with intercurrent infections. Patients with sepsis. Patients receiving drugs affecting immune system like immunosuppressive drugs. Patients on antibiotics. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Condition, Drug	[ "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "B-Condition", "O", "O", "O", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "O", "B-Drug", "I-Drug", "O", "O", "O", "O", "B-Drug", "O", "O" ]	Patients with intercurrent infections. Patients with sepsis. Patients receiving drugs affecting immune system like immunosuppressive drugs. Patients on antibiotics.	[ "Patients", "with", "intercurrent", "infections", ".", "\n", "Patients", "with", "sepsis", ".", "\n", "Patients", "receiving", "drugs", "affecting", "immune", "system", "like", "immunosuppressive", "drugs", ".", "\n", "Patients", "on", "antibiotics", ".", "\n" ]	[ "Drug", "Condition" ]
intercurrent infections is a Condition, sepsis is a Condition, drugs affecting immune system is a Drug, immunosuppressive drugs is a Drug, antibiotics is a Drug	NCT03539718_exc_task1	Sentence: Patients with intercurrent infections. Patients with sepsis. Patients receiving drugs affecting immune system like immunosuppressive drugs. Patients on antibiotics. Instructions: please typing these entity words according to sentence: intercurrent infections, sepsis, drugs affecting immune system, immunosuppressive drugs, antibiotics Options: Condition, Drug	[ "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "B-Condition", "O", "O", "O", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "O", "B-Drug", "I-Drug", "O", "O", "O", "O", "B-Drug", "O", "O" ]	Patients with intercurrent infections. Patients with sepsis. Patients receiving drugs affecting immune system like immunosuppressive drugs. Patients on antibiotics.	[ "Patients", "with", "intercurrent", "infections", ".", "\n", "Patients", "with", "sepsis", ".", "\n", "Patients", "receiving", "drugs", "affecting", "immune", "system", "like", "immunosuppressive", "drugs", ".", "\n", "Patients", "on", "antibiotics", ".", "\n" ]	[ "Drug", "Condition" ]
intercurrent infections, sepsis, drugs affecting immune system, immunosuppressive drugs, antibiotics	NCT03539718_exc_task2	Sentence: Patients with intercurrent infections. Patients with sepsis. Patients receiving drugs affecting immune system like immunosuppressive drugs. Patients on antibiotics. Instructions: please extract entity words from the input sentence	[ "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "B-Condition", "O", "O", "O", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "O", "B-Drug", "I-Drug", "O", "O", "O", "O", "B-Drug", "O", "O" ]	Patients with intercurrent infections. Patients with sepsis. Patients receiving drugs affecting immune system like immunosuppressive drugs. Patients on antibiotics.	[ "Patients", "with", "intercurrent", "infections", ".", "\n", "Patients", "with", "sepsis", ".", "\n", "Patients", "receiving", "drugs", "affecting", "immune", "system", "like", "immunosuppressive", "drugs", ".", "\n", "Patients", "on", "antibiotics", ".", "\n" ]	[ "Drug", "Condition" ]
form is an umlsterm, hematuria is an umlsterm, children is an umlsterm, erythrocytes is an umlsterm, blebs is an umlsterm	MonatsschriftKinderheilkunde.71451182.eng.abstr_task0	Sentence: Aims : A special form of urinary dysmorphic erthrocyte ( G1-cell) was used to differentiate between glomerular and non-glomerular hematuria in 32 children . G1-cells are defined as doughnut shaped erythrocytes with one or more blebs . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O" ]	Aims : A special form of urinary dysmorphic erthrocyte ( G1-cell) was used to differentiate between glomerular and non-glomerular hematuria in 32 children . G1-cells are defined as doughnut shaped erythrocytes with one or more blebs .	[ "Aims", ":", "A", "special", "form", "of", "urinary", "dysmorphic", "erthrocyte", "(", "G1-cell", ")", "was", "used", "to", "differentiate", "between", "glomerular", "and", "non", "-", "glomerular", "hematuria", "in", "32", "children", ".", "G1-cells", "are", "defined", "as", "doughnut", "shaped", "erythrocytes", "with", "one", "or", "more", "blebs", "." ]	[ "umlsterm" ]
form is an umlsterm, hematuria is an umlsterm, children is an umlsterm, erythrocytes is an umlsterm, blebs is an umlsterm	MonatsschriftKinderheilkunde.71451182.eng.abstr_task1	Sentence: Aims : A special form of urinary dysmorphic erthrocyte ( G1-cell) was used to differentiate between glomerular and non-glomerular hematuria in 32 children . G1-cells are defined as doughnut shaped erythrocytes with one or more blebs . Instructions: please typing these entity words according to sentence: form, hematuria, children, erythrocytes, blebs Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O" ]	Aims : A special form of urinary dysmorphic erthrocyte ( G1-cell) was used to differentiate between glomerular and non-glomerular hematuria in 32 children . G1-cells are defined as doughnut shaped erythrocytes with one or more blebs .	[ "Aims", ":", "A", "special", "form", "of", "urinary", "dysmorphic", "erthrocyte", "(", "G1-cell", ")", "was", "used", "to", "differentiate", "between", "glomerular", "and", "non", "-", "glomerular", "hematuria", "in", "32", "children", ".", "G1-cells", "are", "defined", "as", "doughnut", "shaped", "erythrocytes", "with", "one", "or", "more", "blebs", "." ]	[ "umlsterm" ]
form, hematuria, children, erythrocytes, blebs	MonatsschriftKinderheilkunde.71451182.eng.abstr_task2	Sentence: Aims : A special form of urinary dysmorphic erthrocyte ( G1-cell) was used to differentiate between glomerular and non-glomerular hematuria in 32 children . G1-cells are defined as doughnut shaped erythrocytes with one or more blebs . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O" ]	Aims : A special form of urinary dysmorphic erthrocyte ( G1-cell) was used to differentiate between glomerular and non-glomerular hematuria in 32 children . G1-cells are defined as doughnut shaped erythrocytes with one or more blebs .	[ "Aims", ":", "A", "special", "form", "of", "urinary", "dysmorphic", "erthrocyte", "(", "G1-cell", ")", "was", "used", "to", "differentiate", "between", "glomerular", "and", "non", "-", "glomerular", "hematuria", "in", "32", "children", ".", "G1-cells", "are", "defined", "as", "doughnut", "shaped", "erythrocytes", "with", "one", "or", "more", "blebs", "." ]	[ "umlsterm" ]
Patienten is an umlsterm, Angina pectoris is an umlsterm, Belastung is an umlsterm, Haemangiom is an umlsterm, Arteria pulmonalis is an umlsterm, Herzohr is an umlsterm, Ergometrie is an umlsterm, Diagnostik is an umlsterm, Herztumor is an umlsterm, Tumor is an umlsterm, Patient is an umlsterm, Haemangiome is an umlsterm, Tumoren is an umlsterm	ZfuerKardiologie.70860545.ger.abstr_task0	Sentence: Ein Fall eines 73jaehrigen Patienten mit rezidivierender Angina pectoris bei Belastung , verursacht durch eine Haemangiom zwischen der Arteria pulmonalis und dem linken Herzohr , wird vorgestellt . Nach einer pathologischen Ergometrie wurde in der invasiven Diagnostik ein Herztumor diagnostiziert . Der Tumor wurde mittels medianer Sternotomie ohne extrakorporale Zirkulation entfernt . Der postoperative Verlauf war unauffaellig , und der Patient war beschwerdefrei . Haemangiome des Herzens sind seltene Tumoren , die durch eine Operation kurativ behandelt werden koennen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Ein Fall eines 73jaehrigen Patienten mit rezidivierender Angina pectoris bei Belastung , verursacht durch eine Haemangiom zwischen der Arteria pulmonalis und dem linken Herzohr , wird vorgestellt . Nach einer pathologischen Ergometrie wurde in der invasiven Diagnostik ein Herztumor diagnostiziert . Der Tumor wurde mittels medianer Sternotomie ohne extrakorporale Zirkulation entfernt . Der postoperative Verlauf war unauffaellig , und der Patient war beschwerdefrei . Haemangiome des Herzens sind seltene Tumoren , die durch eine Operation kurativ behandelt werden koennen .	[ "Ein", "Fall", "eines", "73jaehrigen", "Patienten", "mit", "rezidivierender", "Angina", "pectoris", "bei", "Belastung", ",", "verursacht", "durch", "eine", "Haemangiom", "zwischen", "der", "Arteria", "pulmonalis", "und", "dem", "linken", "Herzohr", ",", "wird", "vorgestellt", ".", "Nach", "einer", "pathologischen", "Ergometrie", "wurde", "in", "der", "invasiven", "Diagnostik", "ein", "Herztumor", "diagnostiziert", ".", "Der", "Tumor", "wurde", "mittels", "medianer", "Sternotomie", "ohne", "extrakorporale", "Zirkulation", "entfernt", ".", "Der", "postoperative", "Verlauf", "war", "unauffaellig", ",", "und", "der", "Patient", "war", "beschwerdefrei", ".", "Haemangiome", "des", "Herzens", "sind", "seltene", "Tumoren", ",", "die", "durch", "eine", "Operation", "kurativ", "behandelt", "werden", "koennen", "." ]	[ "umlsterm" ]
Patienten is an umlsterm, Angina pectoris is an umlsterm, Belastung is an umlsterm, Haemangiom is an umlsterm, Arteria pulmonalis is an umlsterm, Herzohr is an umlsterm, Ergometrie is an umlsterm, Diagnostik is an umlsterm, Herztumor is an umlsterm, Tumor is an umlsterm, Patient is an umlsterm, Haemangiome is an umlsterm, Tumoren is an umlsterm	ZfuerKardiologie.70860545.ger.abstr_task1	Sentence: Ein Fall eines 73jaehrigen Patienten mit rezidivierender Angina pectoris bei Belastung , verursacht durch eine Haemangiom zwischen der Arteria pulmonalis und dem linken Herzohr , wird vorgestellt . Nach einer pathologischen Ergometrie wurde in der invasiven Diagnostik ein Herztumor diagnostiziert . Der Tumor wurde mittels medianer Sternotomie ohne extrakorporale Zirkulation entfernt . Der postoperative Verlauf war unauffaellig , und der Patient war beschwerdefrei . Haemangiome des Herzens sind seltene Tumoren , die durch eine Operation kurativ behandelt werden koennen . Instructions: please typing these entity words according to sentence: Patienten, Angina pectoris, Belastung, Haemangiom, Arteria pulmonalis, Herzohr, Ergometrie, Diagnostik, Herztumor, Tumor, Patient, Haemangiome, Tumoren Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Ein Fall eines 73jaehrigen Patienten mit rezidivierender Angina pectoris bei Belastung , verursacht durch eine Haemangiom zwischen der Arteria pulmonalis und dem linken Herzohr , wird vorgestellt . Nach einer pathologischen Ergometrie wurde in der invasiven Diagnostik ein Herztumor diagnostiziert . Der Tumor wurde mittels medianer Sternotomie ohne extrakorporale Zirkulation entfernt . Der postoperative Verlauf war unauffaellig , und der Patient war beschwerdefrei . Haemangiome des Herzens sind seltene Tumoren , die durch eine Operation kurativ behandelt werden koennen .	[ "Ein", "Fall", "eines", "73jaehrigen", "Patienten", "mit", "rezidivierender", "Angina", "pectoris", "bei", "Belastung", ",", "verursacht", "durch", "eine", "Haemangiom", "zwischen", "der", "Arteria", "pulmonalis", "und", "dem", "linken", "Herzohr", ",", "wird", "vorgestellt", ".", "Nach", "einer", "pathologischen", "Ergometrie", "wurde", "in", "der", "invasiven", "Diagnostik", "ein", "Herztumor", "diagnostiziert", ".", "Der", "Tumor", "wurde", "mittels", "medianer", "Sternotomie", "ohne", "extrakorporale", "Zirkulation", "entfernt", ".", "Der", "postoperative", "Verlauf", "war", "unauffaellig", ",", "und", "der", "Patient", "war", "beschwerdefrei", ".", "Haemangiome", "des", "Herzens", "sind", "seltene", "Tumoren", ",", "die", "durch", "eine", "Operation", "kurativ", "behandelt", "werden", "koennen", "." ]	[ "umlsterm" ]
Patienten, Angina pectoris, Belastung, Haemangiom, Arteria pulmonalis, Herzohr, Ergometrie, Diagnostik, Herztumor, Tumor, Patient, Haemangiome, Tumoren	ZfuerKardiologie.70860545.ger.abstr_task2	Sentence: Ein Fall eines 73jaehrigen Patienten mit rezidivierender Angina pectoris bei Belastung , verursacht durch eine Haemangiom zwischen der Arteria pulmonalis und dem linken Herzohr , wird vorgestellt . Nach einer pathologischen Ergometrie wurde in der invasiven Diagnostik ein Herztumor diagnostiziert . Der Tumor wurde mittels medianer Sternotomie ohne extrakorporale Zirkulation entfernt . Der postoperative Verlauf war unauffaellig , und der Patient war beschwerdefrei . Haemangiome des Herzens sind seltene Tumoren , die durch eine Operation kurativ behandelt werden koennen . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Ein Fall eines 73jaehrigen Patienten mit rezidivierender Angina pectoris bei Belastung , verursacht durch eine Haemangiom zwischen der Arteria pulmonalis und dem linken Herzohr , wird vorgestellt . Nach einer pathologischen Ergometrie wurde in der invasiven Diagnostik ein Herztumor diagnostiziert . Der Tumor wurde mittels medianer Sternotomie ohne extrakorporale Zirkulation entfernt . Der postoperative Verlauf war unauffaellig , und der Patient war beschwerdefrei . Haemangiome des Herzens sind seltene Tumoren , die durch eine Operation kurativ behandelt werden koennen .	[ "Ein", "Fall", "eines", "73jaehrigen", "Patienten", "mit", "rezidivierender", "Angina", "pectoris", "bei", "Belastung", ",", "verursacht", "durch", "eine", "Haemangiom", "zwischen", "der", "Arteria", "pulmonalis", "und", "dem", "linken", "Herzohr", ",", "wird", "vorgestellt", ".", "Nach", "einer", "pathologischen", "Ergometrie", "wurde", "in", "der", "invasiven", "Diagnostik", "ein", "Herztumor", "diagnostiziert", ".", "Der", "Tumor", "wurde", "mittels", "medianer", "Sternotomie", "ohne", "extrakorporale", "Zirkulation", "entfernt", ".", "Der", "postoperative", "Verlauf", "war", "unauffaellig", ",", "und", "der", "Patient", "war", "beschwerdefrei", ".", "Haemangiome", "des", "Herzens", "sind", "seltene", "Tumoren", ",", "die", "durch", "eine", "Operation", "kurativ", "behandelt", "werden", "koennen", "." ]	[ "umlsterm" ]
HbA1c is a PROTEINAS, glucosa is a NORMALIZABLES, Cr is a NORMALIZABLES, colesterol is a NORMALIZABLES, c - LDL is a NORMALIZABLES, cHDL is a NORMALIZABLES, GOT is a PROTEINAS, GPT is a PROTEINAS, GGT is a PROTEINAS, albúmina is a PROTEINAS, creatinina is a NORMALIZABLES, Glucosa is a NORMALIZABLES, Metilcetona is a NORMALIZABLES, HbA1c is a PROTEINAS, Péptido C is a PROTEINAS, Anticuerpos anti - GAD is a PROTEINAS, anti - IA2 is a PROTEINAS, anti - insulina is a PROTEINAS, IAA is a PROTEINAS, Anticuerpos IgA antitransglutaminasa is a PROTEINAS, Anticuerpos anti - TG is a PROTEINAS, anti - TPO is a PROTEINAS, TSH is a PROTEINAS, HNF1 β is a PROTEINAS, insulina glargina is a PROTEINAS, insulina aspart is a PROTEINAS, fluconazol is a NORMALIZABLES, clotrimazol is a NORMALIZABLES, HbA1c is a PROTEINAS, insulina is a PROTEINAS, insulina is a PROTEINAS, transaminasas is a PROTEINAS	416_task0	Sentence: Se trata de una paciente de 25 años, natural de Ucrania, diagnosticada de diabetes secundaria a agenesia pancreática desde hace 5 años, ingresada en nuestro servicio procedente del servicio de Urgencias por una descompensación hiperglucémica cetósica no acidótica. La paciente desde el diagnóstico ha tenido un control metabólico aceptable con HbA1c menores de 7% con tratamiento dietético y ejercicio. Entre los antecedentes familiares tiene un bisabuelo diabético y padres y hermanos sanos. En la anamnesis, al ingreso la paciente refiere mal control metabólico desde hace dos meses, coincidiendo con el inicio de episodios frecuentes de infecciones urinarias, y últimamente, agravado por candidiasis vulvovaginal y paroniquia en dedos de las manos, con clínica de polidipsia, poliuria intensa y pérdida de 6,4 kg de peso durante este periodo. En la exploración física destaca: talla 167 cm; peso 38,6 kg; IMC 13,4 kg/m2; TA 120/80 mmHg; FC 116 lpm; saturación 97%. Mandíbula en farol. Tiroides grado 0. AC y AP normal. Abdomen blando y depresible, no doloroso, sin masas ni megalias. MMII sin edemas y pulsos periféricos conservados. Sensibilidad vibratoria, con monofilamento y reflejos osteotendinosos conservados. Lesiones eritematosas y pruriginosas en región vulvar y perianal sugestivas de candidiasis. Paroniquia en cuarto dedo mano derecha. Dermopatía diabética extensa en piernas y brazos. Pruebas complementarias: Hemograma normal, VSG 35 mm/h, glucosa 552 mg/dL, Cr 0,8 mg/mL, colesterol total 205 mg/dL, c-LDL 125 mg/dL, cHDL 58 mg/dL. Perfil hepático normal salvo GOT 54 UI (7-32), GPT 63 UI (5-31) y GGT 59 (7-32). Cociente albúmina/creatinina: 0,6µg/mgr. Glucosa orina 5567 mg/dL. Metilcetona en orina 50 mg/dL. HbA1c 16,2%. Péptido C basal 166 pmol/L (298-2350). Anticuerpos anti-GAD 0,2 KU/L (0-0,9), anti-IA2 0,2 KU/L (0-1) y anti-insulina (IAA) 77,2 nU/mL (N<40). Anticuerpos IgA antitransglutaminasa 0,82 KU/L (0-10). Anticuerpos anti-TG 149 (0-40) y anti-TPO 13,3 (0-35). TSH 3,1 Exploración ginecológica: útero bicorne. Exploración del fondo de ojo y retinografía normal. TC abdominopélvico con contaste: agenesia dorsal del páncreas. ECO abdominal: en riñón izquierdo múltiples quistes corticales de tamaño menor de 1 cm, difusos por todo el parénquima renal izquierdo sin evidencia de dilatación del sistema pielocalicial ni otros hallazgos. Riñón derecho normal. Ausencia de cuerpo y cola pancreática. Cultivo de exudado del panadizo creció Klebsiella oxytoca y el cultivo vulvovaginal fue positivo para Candida albicans. Con la sospecha de diabetes tipo MODY se solicitó estudio genético mediante PCR semicuantitativa fluorescente, detectándose delección en heterozigosis de, al menos, los exones del 1 al 8 del gen HNF1 β que se asocia al tipo 5. Se comenzó tratamiento con insulina glargina e insulina aspart 1,3 U/kg. Se administró fluconazol vía oral 100 mg/día (10 días) y un óvulo vaginal en dosis única de clotrimazol 400 mg, desapareciendo las lesiones micóticas. En los controles realizados posteriormente se detectan niveles de HbA1c menores del 6% con disminución progresiva de insulina hasta 0,5 U/kg a los 6 meses del ingreso. A los ocho meses desapareció la dermopatía diabética y a los 18 meses del ingreso, la paciente ha recuperado el peso inicial y los requerimientos de insulina se mantienen en 0,5 U/kg. La función renal se ha mantenido dentro de límites normales y microalbuminuria negativa. Únicamente mantiene un ligero aumento de transaminasas. 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La paciente desde el diagnóstico ha tenido un control metabólico aceptable con HbA1c menores de 7% con tratamiento dietético y ejercicio. Entre los antecedentes familiares tiene un bisabuelo diabético y padres y hermanos sanos. En la anamnesis, al ingreso la paciente refiere mal control metabólico desde hace dos meses, coincidiendo con el inicio de episodios frecuentes de infecciones urinarias, y últimamente, agravado por candidiasis vulvovaginal y paroniquia en dedos de las manos, con clínica de polidipsia, poliuria intensa y pérdida de 6,4 kg de peso durante este periodo. En la exploración física destaca: talla 167 cm; peso 38,6 kg; IMC 13,4 kg/m2; TA 120/80 mmHg; FC 116 lpm; saturación 97%. Mandíbula en farol. Tiroides grado 0. AC y AP normal. Abdomen blando y depresible, no doloroso, sin masas ni megalias. MMII sin edemas y pulsos periféricos conservados. Sensibilidad vibratoria, con monofilamento y reflejos osteotendinosos conservados. Lesiones eritematosas y pruriginosas en región vulvar y perianal sugestivas de candidiasis. Paroniquia en cuarto dedo mano derecha. Dermopatía diabética extensa en piernas y brazos. Pruebas complementarias: Hemograma normal, VSG 35 mm/h, glucosa 552 mg/dL, Cr 0,8 mg/mL, colesterol total 205 mg/dL, c-LDL 125 mg/dL, cHDL 58 mg/dL. Perfil hepático normal salvo GOT 54 UI (7-32), GPT 63 UI (5-31) y GGT 59 (7-32). Cociente albúmina/creatinina: 0,6µg/mgr. Glucosa orina 5567 mg/dL. Metilcetona en orina 50 mg/dL. HbA1c 16,2%. Péptido C basal 166 pmol/L (298-2350). Anticuerpos anti-GAD 0,2 KU/L (0-0,9), anti-IA2 0,2 KU/L (0-1) y anti-insulina (IAA) 77,2 nU/mL (N<40). Anticuerpos IgA antitransglutaminasa 0,82 KU/L (0-10). Anticuerpos anti-TG 149 (0-40) y anti-TPO 13,3 (0-35). TSH 3,1 Exploración ginecológica: útero bicorne. Exploración del fondo de ojo y retinografía normal. TC abdominopélvico con contaste: agenesia dorsal del páncreas. ECO abdominal: en riñón izquierdo múltiples quistes corticales de tamaño menor de 1 cm, difusos por todo el parénquima renal izquierdo sin evidencia de dilatación del sistema pielocalicial ni otros hallazgos. Riñón derecho normal. Ausencia de cuerpo y cola pancreática. Cultivo de exudado del panadizo creció Klebsiella oxytoca y el cultivo vulvovaginal fue positivo para Candida albicans. Con la sospecha de diabetes tipo MODY se solicitó estudio genético mediante PCR semicuantitativa fluorescente, detectándose delección en heterozigosis de, al menos, los exones del 1 al 8 del gen HNF1 β que se asocia al tipo 5. Se comenzó tratamiento con insulina glargina e insulina aspart 1,3 U/kg. Se administró fluconazol vía oral 100 mg/día (10 días) y un óvulo vaginal en dosis única de clotrimazol 400 mg, desapareciendo las lesiones micóticas. En los controles realizados posteriormente se detectan niveles de HbA1c menores del 6% con disminución progresiva de insulina hasta 0,5 U/kg a los 6 meses del ingreso. A los ocho meses desapareció la dermopatía diabética y a los 18 meses del ingreso, la paciente ha recuperado el peso inicial y los requerimientos de insulina se mantienen en 0,5 U/kg. La función renal se ha mantenido dentro de límites normales y microalbuminuria negativa. Únicamente mantiene un ligero aumento de transaminasas.	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HbA1c is a PROTEINAS, glucosa is a NORMALIZABLES, Cr is a NORMALIZABLES, colesterol is a NORMALIZABLES, c - LDL is a NORMALIZABLES, cHDL is a NORMALIZABLES, GOT is a PROTEINAS, GPT is a PROTEINAS, GGT is a PROTEINAS, albúmina is a PROTEINAS, creatinina is a NORMALIZABLES, Glucosa is a NORMALIZABLES, Metilcetona is a NORMALIZABLES, HbA1c is a PROTEINAS, Péptido C is a PROTEINAS, Anticuerpos anti - GAD is a PROTEINAS, anti - IA2 is a PROTEINAS, anti - insulina is a PROTEINAS, IAA is a PROTEINAS, Anticuerpos IgA antitransglutaminasa is a PROTEINAS, Anticuerpos anti - TG is a PROTEINAS, anti - TPO is a PROTEINAS, TSH is a PROTEINAS, HNF1 β is a PROTEINAS, insulina glargina is a PROTEINAS, insulina aspart is a PROTEINAS, fluconazol is a NORMALIZABLES, clotrimazol is a NORMALIZABLES, HbA1c is a PROTEINAS, insulina is a PROTEINAS, insulina is a PROTEINAS, transaminasas is a PROTEINAS	416_task1	Sentence: Se trata de una paciente de 25 años, natural de Ucrania, diagnosticada de diabetes secundaria a agenesia pancreática desde hace 5 años, ingresada en nuestro servicio procedente del servicio de Urgencias por una descompensación hiperglucémica cetósica no acidótica. La paciente desde el diagnóstico ha tenido un control metabólico aceptable con HbA1c menores de 7% con tratamiento dietético y ejercicio. Entre los antecedentes familiares tiene un bisabuelo diabético y padres y hermanos sanos. En la anamnesis, al ingreso la paciente refiere mal control metabólico desde hace dos meses, coincidiendo con el inicio de episodios frecuentes de infecciones urinarias, y últimamente, agravado por candidiasis vulvovaginal y paroniquia en dedos de las manos, con clínica de polidipsia, poliuria intensa y pérdida de 6,4 kg de peso durante este periodo. En la exploración física destaca: talla 167 cm; peso 38,6 kg; IMC 13,4 kg/m2; TA 120/80 mmHg; FC 116 lpm; saturación 97%. Mandíbula en farol. Tiroides grado 0. AC y AP normal. Abdomen blando y depresible, no doloroso, sin masas ni megalias. MMII sin edemas y pulsos periféricos conservados. Sensibilidad vibratoria, con monofilamento y reflejos osteotendinosos conservados. Lesiones eritematosas y pruriginosas en región vulvar y perianal sugestivas de candidiasis. Paroniquia en cuarto dedo mano derecha. Dermopatía diabética extensa en piernas y brazos. Pruebas complementarias: Hemograma normal, VSG 35 mm/h, glucosa 552 mg/dL, Cr 0,8 mg/mL, colesterol total 205 mg/dL, c-LDL 125 mg/dL, cHDL 58 mg/dL. Perfil hepático normal salvo GOT 54 UI (7-32), GPT 63 UI (5-31) y GGT 59 (7-32). Cociente albúmina/creatinina: 0,6µg/mgr. Glucosa orina 5567 mg/dL. Metilcetona en orina 50 mg/dL. HbA1c 16,2%. Péptido C basal 166 pmol/L (298-2350). Anticuerpos anti-GAD 0,2 KU/L (0-0,9), anti-IA2 0,2 KU/L (0-1) y anti-insulina (IAA) 77,2 nU/mL (N<40). Anticuerpos IgA antitransglutaminasa 0,82 KU/L (0-10). Anticuerpos anti-TG 149 (0-40) y anti-TPO 13,3 (0-35). TSH 3,1 Exploración ginecológica: útero bicorne. Exploración del fondo de ojo y retinografía normal. TC abdominopélvico con contaste: agenesia dorsal del páncreas. ECO abdominal: en riñón izquierdo múltiples quistes corticales de tamaño menor de 1 cm, difusos por todo el parénquima renal izquierdo sin evidencia de dilatación del sistema pielocalicial ni otros hallazgos. Riñón derecho normal. Ausencia de cuerpo y cola pancreática. Cultivo de exudado del panadizo creció Klebsiella oxytoca y el cultivo vulvovaginal fue positivo para Candida albicans. Con la sospecha de diabetes tipo MODY se solicitó estudio genético mediante PCR semicuantitativa fluorescente, detectándose delección en heterozigosis de, al menos, los exones del 1 al 8 del gen HNF1 β que se asocia al tipo 5. Se comenzó tratamiento con insulina glargina e insulina aspart 1,3 U/kg. Se administró fluconazol vía oral 100 mg/día (10 días) y un óvulo vaginal en dosis única de clotrimazol 400 mg, desapareciendo las lesiones micóticas. En los controles realizados posteriormente se detectan niveles de HbA1c menores del 6% con disminución progresiva de insulina hasta 0,5 U/kg a los 6 meses del ingreso. A los ocho meses desapareció la dermopatía diabética y a los 18 meses del ingreso, la paciente ha recuperado el peso inicial y los requerimientos de insulina se mantienen en 0,5 U/kg. La función renal se ha mantenido dentro de límites normales y microalbuminuria negativa. Únicamente mantiene un ligero aumento de transaminasas. Instructions: please typing these entity words according to sentence: HbA1c, glucosa, Cr, colesterol, c - LDL, cHDL, GOT, GPT, GGT, albúmina, creatinina, Glucosa, Metilcetona, HbA1c, Péptido C, Anticuerpos anti - GAD, anti - IA2, anti - insulina, IAA, Anticuerpos IgA antitransglutaminasa, Anticuerpos anti - TG, anti - TPO, TSH, HNF1 β, insulina glargina, insulina aspart, fluconazol, clotrimazol, HbA1c, insulina, insulina, transaminasas Options: NORMALIZABLES, PROTEINAS	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "I-NORMALIZABLES", "I-NORMALIZABLES", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "B-PROTEINAS", "I-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "I-PROTEINAS", "I-PROTEINAS", "I-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "I-PROTEINAS", "I-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "I-PROTEINAS", "I-PROTEINAS", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "I-PROTEINAS", "I-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "I-PROTEINAS", "I-PROTEINAS", "I-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "I-PROTEINAS", "I-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "I-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "I-PROTEINAS", "O", "B-PROTEINAS", "I-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O" ]	Se trata de una paciente de 25 años, natural de Ucrania, diagnosticada de diabetes secundaria a agenesia pancreática desde hace 5 años, ingresada en nuestro servicio procedente del servicio de Urgencias por una descompensación hiperglucémica cetósica no acidótica. La paciente desde el diagnóstico ha tenido un control metabólico aceptable con HbA1c menores de 7% con tratamiento dietético y ejercicio. Entre los antecedentes familiares tiene un bisabuelo diabético y padres y hermanos sanos. En la anamnesis, al ingreso la paciente refiere mal control metabólico desde hace dos meses, coincidiendo con el inicio de episodios frecuentes de infecciones urinarias, y últimamente, agravado por candidiasis vulvovaginal y paroniquia en dedos de las manos, con clínica de polidipsia, poliuria intensa y pérdida de 6,4 kg de peso durante este periodo. En la exploración física destaca: talla 167 cm; peso 38,6 kg; IMC 13,4 kg/m2; TA 120/80 mmHg; FC 116 lpm; saturación 97%. Mandíbula en farol. Tiroides grado 0. AC y AP normal. Abdomen blando y depresible, no doloroso, sin masas ni megalias. MMII sin edemas y pulsos periféricos conservados. Sensibilidad vibratoria, con monofilamento y reflejos osteotendinosos conservados. Lesiones eritematosas y pruriginosas en región vulvar y perianal sugestivas de candidiasis. Paroniquia en cuarto dedo mano derecha. Dermopatía diabética extensa en piernas y brazos. Pruebas complementarias: Hemograma normal, VSG 35 mm/h, glucosa 552 mg/dL, Cr 0,8 mg/mL, colesterol total 205 mg/dL, c-LDL 125 mg/dL, cHDL 58 mg/dL. Perfil hepático normal salvo GOT 54 UI (7-32), GPT 63 UI (5-31) y GGT 59 (7-32). Cociente albúmina/creatinina: 0,6µg/mgr. Glucosa orina 5567 mg/dL. Metilcetona en orina 50 mg/dL. HbA1c 16,2%. Péptido C basal 166 pmol/L (298-2350). Anticuerpos anti-GAD 0,2 KU/L (0-0,9), anti-IA2 0,2 KU/L (0-1) y anti-insulina (IAA) 77,2 nU/mL (N<40). Anticuerpos IgA antitransglutaminasa 0,82 KU/L (0-10). Anticuerpos anti-TG 149 (0-40) y anti-TPO 13,3 (0-35). TSH 3,1 Exploración ginecológica: útero bicorne. Exploración del fondo de ojo y retinografía normal. TC abdominopélvico con contaste: agenesia dorsal del páncreas. ECO abdominal: en riñón izquierdo múltiples quistes corticales de tamaño menor de 1 cm, difusos por todo el parénquima renal izquierdo sin evidencia de dilatación del sistema pielocalicial ni otros hallazgos. Riñón derecho normal. Ausencia de cuerpo y cola pancreática. Cultivo de exudado del panadizo creció Klebsiella oxytoca y el cultivo vulvovaginal fue positivo para Candida albicans. Con la sospecha de diabetes tipo MODY se solicitó estudio genético mediante PCR semicuantitativa fluorescente, detectándose delección en heterozigosis de, al menos, los exones del 1 al 8 del gen HNF1 β que se asocia al tipo 5. Se comenzó tratamiento con insulina glargina e insulina aspart 1,3 U/kg. Se administró fluconazol vía oral 100 mg/día (10 días) y un óvulo vaginal en dosis única de clotrimazol 400 mg, desapareciendo las lesiones micóticas. En los controles realizados posteriormente se detectan niveles de HbA1c menores del 6% con disminución progresiva de insulina hasta 0,5 U/kg a los 6 meses del ingreso. A los ocho meses desapareció la dermopatía diabética y a los 18 meses del ingreso, la paciente ha recuperado el peso inicial y los requerimientos de insulina se mantienen en 0,5 U/kg. La función renal se ha mantenido dentro de límites normales y microalbuminuria negativa. Únicamente mantiene un ligero aumento de transaminasas.	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HbA1c, glucosa, Cr, colesterol, c - LDL, cHDL, GOT, GPT, GGT, albúmina, creatinina, Glucosa, Metilcetona, HbA1c, Péptido C, Anticuerpos anti - GAD, anti - IA2, anti - insulina, IAA, Anticuerpos IgA antitransglutaminasa, Anticuerpos anti - TG, anti - TPO, TSH, HNF1 β, insulina glargina, insulina aspart, fluconazol, clotrimazol, HbA1c, insulina, insulina, transaminasas	416_task2	Sentence: Se trata de una paciente de 25 años, natural de Ucrania, diagnosticada de diabetes secundaria a agenesia pancreática desde hace 5 años, ingresada en nuestro servicio procedente del servicio de Urgencias por una descompensación hiperglucémica cetósica no acidótica. La paciente desde el diagnóstico ha tenido un control metabólico aceptable con HbA1c menores de 7% con tratamiento dietético y ejercicio. Entre los antecedentes familiares tiene un bisabuelo diabético y padres y hermanos sanos. En la anamnesis, al ingreso la paciente refiere mal control metabólico desde hace dos meses, coincidiendo con el inicio de episodios frecuentes de infecciones urinarias, y últimamente, agravado por candidiasis vulvovaginal y paroniquia en dedos de las manos, con clínica de polidipsia, poliuria intensa y pérdida de 6,4 kg de peso durante este periodo. En la exploración física destaca: talla 167 cm; peso 38,6 kg; IMC 13,4 kg/m2; TA 120/80 mmHg; FC 116 lpm; saturación 97%. Mandíbula en farol. Tiroides grado 0. AC y AP normal. Abdomen blando y depresible, no doloroso, sin masas ni megalias. MMII sin edemas y pulsos periféricos conservados. Sensibilidad vibratoria, con monofilamento y reflejos osteotendinosos conservados. Lesiones eritematosas y pruriginosas en región vulvar y perianal sugestivas de candidiasis. Paroniquia en cuarto dedo mano derecha. Dermopatía diabética extensa en piernas y brazos. Pruebas complementarias: Hemograma normal, VSG 35 mm/h, glucosa 552 mg/dL, Cr 0,8 mg/mL, colesterol total 205 mg/dL, c-LDL 125 mg/dL, cHDL 58 mg/dL. Perfil hepático normal salvo GOT 54 UI (7-32), GPT 63 UI (5-31) y GGT 59 (7-32). Cociente albúmina/creatinina: 0,6µg/mgr. Glucosa orina 5567 mg/dL. Metilcetona en orina 50 mg/dL. HbA1c 16,2%. Péptido C basal 166 pmol/L (298-2350). Anticuerpos anti-GAD 0,2 KU/L (0-0,9), anti-IA2 0,2 KU/L (0-1) y anti-insulina (IAA) 77,2 nU/mL (N<40). Anticuerpos IgA antitransglutaminasa 0,82 KU/L (0-10). Anticuerpos anti-TG 149 (0-40) y anti-TPO 13,3 (0-35). TSH 3,1 Exploración ginecológica: útero bicorne. Exploración del fondo de ojo y retinografía normal. TC abdominopélvico con contaste: agenesia dorsal del páncreas. ECO abdominal: en riñón izquierdo múltiples quistes corticales de tamaño menor de 1 cm, difusos por todo el parénquima renal izquierdo sin evidencia de dilatación del sistema pielocalicial ni otros hallazgos. Riñón derecho normal. Ausencia de cuerpo y cola pancreática. Cultivo de exudado del panadizo creció Klebsiella oxytoca y el cultivo vulvovaginal fue positivo para Candida albicans. Con la sospecha de diabetes tipo MODY se solicitó estudio genético mediante PCR semicuantitativa fluorescente, detectándose delección en heterozigosis de, al menos, los exones del 1 al 8 del gen HNF1 β que se asocia al tipo 5. Se comenzó tratamiento con insulina glargina e insulina aspart 1,3 U/kg. Se administró fluconazol vía oral 100 mg/día (10 días) y un óvulo vaginal en dosis única de clotrimazol 400 mg, desapareciendo las lesiones micóticas. En los controles realizados posteriormente se detectan niveles de HbA1c menores del 6% con disminución progresiva de insulina hasta 0,5 U/kg a los 6 meses del ingreso. A los ocho meses desapareció la dermopatía diabética y a los 18 meses del ingreso, la paciente ha recuperado el peso inicial y los requerimientos de insulina se mantienen en 0,5 U/kg. La función renal se ha mantenido dentro de límites normales y microalbuminuria negativa. Únicamente mantiene un ligero aumento de transaminasas. 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La paciente desde el diagnóstico ha tenido un control metabólico aceptable con HbA1c menores de 7% con tratamiento dietético y ejercicio. Entre los antecedentes familiares tiene un bisabuelo diabético y padres y hermanos sanos. En la anamnesis, al ingreso la paciente refiere mal control metabólico desde hace dos meses, coincidiendo con el inicio de episodios frecuentes de infecciones urinarias, y últimamente, agravado por candidiasis vulvovaginal y paroniquia en dedos de las manos, con clínica de polidipsia, poliuria intensa y pérdida de 6,4 kg de peso durante este periodo. En la exploración física destaca: talla 167 cm; peso 38,6 kg; IMC 13,4 kg/m2; TA 120/80 mmHg; FC 116 lpm; saturación 97%. Mandíbula en farol. Tiroides grado 0. AC y AP normal. Abdomen blando y depresible, no doloroso, sin masas ni megalias. MMII sin edemas y pulsos periféricos conservados. Sensibilidad vibratoria, con monofilamento y reflejos osteotendinosos conservados. Lesiones eritematosas y pruriginosas en región vulvar y perianal sugestivas de candidiasis. Paroniquia en cuarto dedo mano derecha. Dermopatía diabética extensa en piernas y brazos. Pruebas complementarias: Hemograma normal, VSG 35 mm/h, glucosa 552 mg/dL, Cr 0,8 mg/mL, colesterol total 205 mg/dL, c-LDL 125 mg/dL, cHDL 58 mg/dL. Perfil hepático normal salvo GOT 54 UI (7-32), GPT 63 UI (5-31) y GGT 59 (7-32). Cociente albúmina/creatinina: 0,6µg/mgr. Glucosa orina 5567 mg/dL. Metilcetona en orina 50 mg/dL. HbA1c 16,2%. Péptido C basal 166 pmol/L (298-2350). Anticuerpos anti-GAD 0,2 KU/L (0-0,9), anti-IA2 0,2 KU/L (0-1) y anti-insulina (IAA) 77,2 nU/mL (N<40). Anticuerpos IgA antitransglutaminasa 0,82 KU/L (0-10). Anticuerpos anti-TG 149 (0-40) y anti-TPO 13,3 (0-35). TSH 3,1 Exploración ginecológica: útero bicorne. Exploración del fondo de ojo y retinografía normal. TC abdominopélvico con contaste: agenesia dorsal del páncreas. ECO abdominal: en riñón izquierdo múltiples quistes corticales de tamaño menor de 1 cm, difusos por todo el parénquima renal izquierdo sin evidencia de dilatación del sistema pielocalicial ni otros hallazgos. Riñón derecho normal. Ausencia de cuerpo y cola pancreática. Cultivo de exudado del panadizo creció Klebsiella oxytoca y el cultivo vulvovaginal fue positivo para Candida albicans. Con la sospecha de diabetes tipo MODY se solicitó estudio genético mediante PCR semicuantitativa fluorescente, detectándose delección en heterozigosis de, al menos, los exones del 1 al 8 del gen HNF1 β que se asocia al tipo 5. Se comenzó tratamiento con insulina glargina e insulina aspart 1,3 U/kg. Se administró fluconazol vía oral 100 mg/día (10 días) y un óvulo vaginal en dosis única de clotrimazol 400 mg, desapareciendo las lesiones micóticas. En los controles realizados posteriormente se detectan niveles de HbA1c menores del 6% con disminución progresiva de insulina hasta 0,5 U/kg a los 6 meses del ingreso. A los ocho meses desapareció la dermopatía diabética y a los 18 meses del ingreso, la paciente ha recuperado el peso inicial y los requerimientos de insulina se mantienen en 0,5 U/kg. La función renal se ha mantenido dentro de límites normales y microalbuminuria negativa. Únicamente mantiene un ligero aumento de transaminasas.	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"400", "mg", ",", "desapareciendo", "las", "lesiones", "micóticas", ".", "\n", "En", "los", "controles", "realizados", "posteriormente", "se", "detectan", "niveles", "de", "HbA1c", "menores", "del", "6", "%", "con", "disminución", "progresiva", "de", "insulina", "hasta", "0,5", "U", "/", "kg", "a", "los", "6", "meses", "del", "ingreso", ".", "A", "los", "ocho", "meses", "desapareció", "la", "dermopatía", "diabética", "y", "a", "los", "18", "meses", "del", "ingreso", ",", "la", "paciente", "ha", "recuperado", "el", "peso", "inicial", "y", "los", "requerimientos", "de", "insulina", "se", "mantienen", "en", "0,5", "U", "/", "kg", ".", "La", "función", "renal", "se", "ha", "mantenido", "dentro", "de", "límites", "normales", "y", "microalbuminuria", "negativa", ".", "Únicamente", "mantiene", "un", "ligero", "aumento", "de", "transaminasas", ".", "\n\n" ]	[ "PROTEINAS", "NORMALIZABLES" ]
alexithymia is a Intervention_Other, emotion regulation measures is a Intervention_Psychological, 12-week cognitive - behavioral intervention for alcohol dependence is a Intervention_Psychological, poorer emotion regulation skills is a Outcome_Mental, fewer percent days abstinent is a Outcome_Mental, greater alcohol dependence severity is a Outcome_Mental, several high - risk drinking situations is a Outcome_Mental, those seeking treatment for alcohol dependence . is a Participant_Condition	53474_task0	Sentence: The relationship of alexithymia to emotional dysregulation within an alcohol dependent treatment sample . Difficulties regulating emotions have implications for the development , maintenance , and recovery from alcohol problems . One construct thought to impede the regulation of emotion is alexithymia . Alexithymia is characterized by difficulties identifying , differentiating and expressing feelings , a limited imagination and fantasy life , and an externally-oriented thinking style ( e.g. , prefer talking about daily activities rather than feelings ) . Given that poor emotion regulation skills have been found to predict posttreatment levels of alcohol use , and that several defining characteristics of alexithymia bear similarity to deficits in emotion regulation skills , it is possible that alexithymia may predict poorer alcohol treatment outcomes . Thus , the present study first examined the relationship of alexithymia to several other emotion regulation measures and then investigated the impact of alexithymia on attrition and alcohol treatment outcomes in men and women ( N=77 ) enrolled in a 12-week cognitive-behavioral intervention for alcohol dependence . At baseline , higher scores on alexithymia were associated poorer emotion regulation skills , fewer percent days abstinent , greater alcohol dependence severity , and several high-risk drinking situations . Alexithymia was unrelated to attrition and to level of alcohol consumption at posttreatment . Overall , the construct of alexithymia is shown to be related to several theoretically-related constructs ( e.g. , emotion regulation , mindfulness ) but demonstrated a limited relationship to drinking outcomes in those seeking treatment for alcohol dependence . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Psychological, Intervention_Other, Participant_Condition, Outcome_Mental	[ "O", "O", "O", "B-Intervention_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition" ]	The relationship of alexithymia to emotional dysregulation within an alcohol dependent treatment sample . Difficulties regulating emotions have implications for the development , maintenance , and recovery from alcohol problems . One construct thought to impede the regulation of emotion is alexithymia . Alexithymia is characterized by difficulties identifying , differentiating and expressing feelings , a limited imagination and fantasy life , and an externally-oriented thinking style ( e.g. , prefer talking about daily activities rather than feelings ) . Given that poor emotion regulation skills have been found to predict posttreatment levels of alcohol use , and that several defining characteristics of alexithymia bear similarity to deficits in emotion regulation skills , it is possible that alexithymia may predict poorer alcohol treatment outcomes . Thus , the present study first examined the relationship of alexithymia to several other emotion regulation measures and then investigated the impact of alexithymia on attrition and alcohol treatment outcomes in men and women ( N=77 ) enrolled in a 12-week cognitive-behavioral intervention for alcohol dependence . At baseline , higher scores on alexithymia were associated poorer emotion regulation skills , fewer percent days abstinent , greater alcohol dependence severity , and several high-risk drinking situations . Alexithymia was unrelated to attrition and to level of alcohol consumption at posttreatment . Overall , the construct of alexithymia is shown to be related to several theoretically-related constructs ( e.g. , emotion regulation , mindfulness ) but demonstrated a limited relationship to drinking outcomes in those seeking treatment for alcohol dependence .	[ "The", "relationship", "of", "alexithymia", "to", "emotional", "dysregulation", "within", "an", "alcohol", "dependent", "treatment", "sample", ".", "Difficulties", "regulating", "emotions", "have", "implications", "for", "the", "development", ",", "maintenance", ",", "and", "recovery", "from", "alcohol", "problems", ".", "One", "construct", "thought", "to", "impede", "the", "regulation", "of", "emotion", "is", "alexithymia", ".", "Alexithymia", "is", "characterized", "by", "difficulties", "identifying", ",", "differentiating", "and", "expressing", "feelings", ",", "a", "limited", "imagination", "and", "fantasy", "life", ",", "and", "an", "externally", "-", "oriented", "thinking", "style", "(", "e.g", ".", ",", "prefer", "talking", "about", "daily", "activities", "rather", "than", "feelings", ")", ".", "Given", "that", "poor", "emotion", "regulation", "skills", "have", "been", "found", "to", "predict", "posttreatment", "levels", "of", "alcohol", "use", ",", "and", "that", "several", "defining", "characteristics", "of", "alexithymia", "bear", "similarity", "to", "deficits", "in", "emotion", "regulation", "skills", ",", "it", "is", "possible", "that", "alexithymia", "may", "predict", "poorer", "alcohol", "treatment", "outcomes", ".", "Thus", ",", "the", "present", "study", "first", "examined", "the", "relationship", "of", "alexithymia", "to", "several", "other", "emotion", "regulation", "measures", "and", "then", "investigated", "the", "impact", "of", "alexithymia", "on", "attrition", "and", "alcohol", "treatment", "outcomes", "in", "men", "and", "women", "(", "N=77", ")", "enrolled", "in", "a", "12-week", "cognitive", "-", "behavioral", "intervention", "for", "alcohol", "dependence", ".", "At", "baseline", ",", "higher", "scores", "on", "alexithymia", "were", "associated", "poorer", "emotion", "regulation", "skills", ",", "fewer", "percent", "days", "abstinent", ",", "greater", "alcohol", "dependence", "severity", ",", "and", "several", "high", "-", "risk", "drinking", "situations", ".", "Alexithymia", "was", "unrelated", "to", "attrition", "and", "to", "level", "of", "alcohol", "consumption", "at", "posttreatment", ".", "Overall", ",", "the", "construct", "of", "alexithymia", "is", "shown", "to", "be", "related", "to", "several", "theoretically", "-", "related", "constructs", "(", "e.g", ".", ",", "emotion", "regulation", ",", "mindfulness", ")", "but", "demonstrated", "a", "limited", "relationship", "to", "drinking", "outcomes", "in", "those", "seeking", "treatment", "for", "alcohol", "dependence", "." ]	[ "Intervention_Psychological", "Participant_Condition", "Outcome_Mental", "Intervention_Other" ]
alexithymia is a Intervention_Other, emotion regulation measures is a Intervention_Psychological, 12-week cognitive - behavioral intervention for alcohol dependence is a Intervention_Psychological, poorer emotion regulation skills is a Outcome_Mental, fewer percent days abstinent is a Outcome_Mental, greater alcohol dependence severity is a Outcome_Mental, several high - risk drinking situations is a Outcome_Mental, those seeking treatment for alcohol dependence . is a Participant_Condition	53474_task1	Sentence: The relationship of alexithymia to emotional dysregulation within an alcohol dependent treatment sample . Difficulties regulating emotions have implications for the development , maintenance , and recovery from alcohol problems . One construct thought to impede the regulation of emotion is alexithymia . Alexithymia is characterized by difficulties identifying , differentiating and expressing feelings , a limited imagination and fantasy life , and an externally-oriented thinking style ( e.g. , prefer talking about daily activities rather than feelings ) . Given that poor emotion regulation skills have been found to predict posttreatment levels of alcohol use , and that several defining characteristics of alexithymia bear similarity to deficits in emotion regulation skills , it is possible that alexithymia may predict poorer alcohol treatment outcomes . Thus , the present study first examined the relationship of alexithymia to several other emotion regulation measures and then investigated the impact of alexithymia on attrition and alcohol treatment outcomes in men and women ( N=77 ) enrolled in a 12-week cognitive-behavioral intervention for alcohol dependence . At baseline , higher scores on alexithymia were associated poorer emotion regulation skills , fewer percent days abstinent , greater alcohol dependence severity , and several high-risk drinking situations . Alexithymia was unrelated to attrition and to level of alcohol consumption at posttreatment . Overall , the construct of alexithymia is shown to be related to several theoretically-related constructs ( e.g. , emotion regulation , mindfulness ) but demonstrated a limited relationship to drinking outcomes in those seeking treatment for alcohol dependence . Instructions: please typing these entity words according to sentence: alexithymia, emotion regulation measures, 12-week cognitive - behavioral intervention for alcohol dependence, poorer emotion regulation skills, fewer percent days abstinent, greater alcohol dependence severity, several high - risk drinking situations, those seeking treatment for alcohol dependence . Options: Intervention_Psychological, Intervention_Other, Participant_Condition, Outcome_Mental	[ "O", "O", "O", "B-Intervention_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition" ]	The relationship of alexithymia to emotional dysregulation within an alcohol dependent treatment sample . Difficulties regulating emotions have implications for the development , maintenance , and recovery from alcohol problems . One construct thought to impede the regulation of emotion is alexithymia . Alexithymia is characterized by difficulties identifying , differentiating and expressing feelings , a limited imagination and fantasy life , and an externally-oriented thinking style ( e.g. , prefer talking about daily activities rather than feelings ) . Given that poor emotion regulation skills have been found to predict posttreatment levels of alcohol use , and that several defining characteristics of alexithymia bear similarity to deficits in emotion regulation skills , it is possible that alexithymia may predict poorer alcohol treatment outcomes . Thus , the present study first examined the relationship of alexithymia to several other emotion regulation measures and then investigated the impact of alexithymia on attrition and alcohol treatment outcomes in men and women ( N=77 ) enrolled in a 12-week cognitive-behavioral intervention for alcohol dependence . At baseline , higher scores on alexithymia were associated poorer emotion regulation skills , fewer percent days abstinent , greater alcohol dependence severity , and several high-risk drinking situations . Alexithymia was unrelated to attrition and to level of alcohol consumption at posttreatment . Overall , the construct of alexithymia is shown to be related to several theoretically-related constructs ( e.g. , emotion regulation , mindfulness ) but demonstrated a limited relationship to drinking outcomes in those seeking treatment for alcohol dependence .	[ "The", "relationship", "of", "alexithymia", "to", "emotional", "dysregulation", "within", "an", "alcohol", "dependent", "treatment", "sample", ".", "Difficulties", "regulating", "emotions", "have", "implications", "for", "the", "development", ",", "maintenance", ",", "and", "recovery", "from", "alcohol", "problems", ".", "One", "construct", "thought", "to", "impede", "the", "regulation", "of", "emotion", "is", "alexithymia", ".", "Alexithymia", "is", "characterized", "by", "difficulties", "identifying", ",", "differentiating", "and", "expressing", "feelings", ",", "a", "limited", "imagination", "and", "fantasy", "life", ",", "and", "an", "externally", "-", "oriented", "thinking", "style", "(", "e.g", ".", ",", "prefer", "talking", "about", "daily", "activities", "rather", "than", "feelings", ")", ".", "Given", "that", "poor", "emotion", "regulation", "skills", "have", "been", "found", "to", "predict", "posttreatment", "levels", "of", "alcohol", "use", ",", "and", "that", "several", "defining", "characteristics", "of", "alexithymia", "bear", "similarity", "to", "deficits", "in", "emotion", "regulation", "skills", ",", "it", "is", "possible", "that", "alexithymia", "may", "predict", "poorer", "alcohol", "treatment", "outcomes", ".", "Thus", ",", "the", "present", "study", "first", "examined", "the", "relationship", "of", "alexithymia", "to", "several", "other", "emotion", "regulation", "measures", "and", "then", "investigated", "the", "impact", "of", "alexithymia", "on", "attrition", "and", "alcohol", "treatment", "outcomes", "in", "men", "and", "women", "(", "N=77", ")", "enrolled", "in", "a", "12-week", "cognitive", "-", "behavioral", "intervention", "for", "alcohol", "dependence", ".", "At", "baseline", ",", "higher", "scores", "on", "alexithymia", "were", "associated", "poorer", "emotion", "regulation", "skills", ",", "fewer", "percent", "days", "abstinent", ",", "greater", "alcohol", "dependence", "severity", ",", "and", "several", "high", "-", "risk", "drinking", "situations", ".", "Alexithymia", "was", "unrelated", "to", "attrition", "and", "to", "level", "of", "alcohol", "consumption", "at", "posttreatment", ".", "Overall", ",", "the", "construct", "of", "alexithymia", "is", "shown", "to", "be", "related", "to", "several", "theoretically", "-", "related", "constructs", "(", "e.g", ".", ",", "emotion", "regulation", ",", "mindfulness", ")", "but", "demonstrated", "a", "limited", "relationship", "to", "drinking", "outcomes", "in", "those", "seeking", "treatment", "for", "alcohol", "dependence", "." ]	[ "Intervention_Psychological", "Participant_Condition", "Outcome_Mental", "Intervention_Other" ]
alexithymia, emotion regulation measures, 12-week cognitive - behavioral intervention for alcohol dependence, poorer emotion regulation skills, fewer percent days abstinent, greater alcohol dependence severity, several high - risk drinking situations, those seeking treatment for alcohol dependence .	53474_task2	Sentence: The relationship of alexithymia to emotional dysregulation within an alcohol dependent treatment sample . Difficulties regulating emotions have implications for the development , maintenance , and recovery from alcohol problems . One construct thought to impede the regulation of emotion is alexithymia . Alexithymia is characterized by difficulties identifying , differentiating and expressing feelings , a limited imagination and fantasy life , and an externally-oriented thinking style ( e.g. , prefer talking about daily activities rather than feelings ) . Given that poor emotion regulation skills have been found to predict posttreatment levels of alcohol use , and that several defining characteristics of alexithymia bear similarity to deficits in emotion regulation skills , it is possible that alexithymia may predict poorer alcohol treatment outcomes . Thus , the present study first examined the relationship of alexithymia to several other emotion regulation measures and then investigated the impact of alexithymia on attrition and alcohol treatment outcomes in men and women ( N=77 ) enrolled in a 12-week cognitive-behavioral intervention for alcohol dependence . At baseline , higher scores on alexithymia were associated poorer emotion regulation skills , fewer percent days abstinent , greater alcohol dependence severity , and several high-risk drinking situations . Alexithymia was unrelated to attrition and to level of alcohol consumption at posttreatment . Overall , the construct of alexithymia is shown to be related to several theoretically-related constructs ( e.g. , emotion regulation , mindfulness ) but demonstrated a limited relationship to drinking outcomes in those seeking treatment for alcohol dependence . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-Intervention_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition" ]	The relationship of alexithymia to emotional dysregulation within an alcohol dependent treatment sample . Difficulties regulating emotions have implications for the development , maintenance , and recovery from alcohol problems . One construct thought to impede the regulation of emotion is alexithymia . Alexithymia is characterized by difficulties identifying , differentiating and expressing feelings , a limited imagination and fantasy life , and an externally-oriented thinking style ( e.g. , prefer talking about daily activities rather than feelings ) . Given that poor emotion regulation skills have been found to predict posttreatment levels of alcohol use , and that several defining characteristics of alexithymia bear similarity to deficits in emotion regulation skills , it is possible that alexithymia may predict poorer alcohol treatment outcomes . Thus , the present study first examined the relationship of alexithymia to several other emotion regulation measures and then investigated the impact of alexithymia on attrition and alcohol treatment outcomes in men and women ( N=77 ) enrolled in a 12-week cognitive-behavioral intervention for alcohol dependence . At baseline , higher scores on alexithymia were associated poorer emotion regulation skills , fewer percent days abstinent , greater alcohol dependence severity , and several high-risk drinking situations . Alexithymia was unrelated to attrition and to level of alcohol consumption at posttreatment . Overall , the construct of alexithymia is shown to be related to several theoretically-related constructs ( e.g. , emotion regulation , mindfulness ) but demonstrated a limited relationship to drinking outcomes in those seeking treatment for alcohol dependence .	[ "The", "relationship", "of", "alexithymia", "to", "emotional", "dysregulation", "within", "an", "alcohol", "dependent", "treatment", "sample", ".", "Difficulties", "regulating", "emotions", "have", "implications", "for", "the", "development", ",", "maintenance", ",", "and", "recovery", "from", "alcohol", "problems", ".", "One", "construct", "thought", "to", "impede", "the", "regulation", "of", "emotion", "is", "alexithymia", ".", "Alexithymia", "is", "characterized", "by", "difficulties", "identifying", ",", "differentiating", "and", "expressing", "feelings", ",", "a", "limited", "imagination", "and", "fantasy", "life", ",", "and", "an", "externally", "-", "oriented", "thinking", "style", "(", "e.g", ".", ",", "prefer", "talking", "about", "daily", "activities", "rather", "than", "feelings", ")", ".", "Given", "that", "poor", "emotion", "regulation", "skills", "have", "been", "found", "to", "predict", "posttreatment", "levels", "of", "alcohol", "use", ",", "and", "that", "several", "defining", "characteristics", "of", "alexithymia", "bear", "similarity", "to", "deficits", "in", "emotion", "regulation", "skills", ",", "it", "is", "possible", "that", "alexithymia", "may", "predict", "poorer", "alcohol", "treatment", "outcomes", ".", "Thus", ",", "the", "present", "study", "first", "examined", "the", "relationship", "of", "alexithymia", "to", "several", "other", "emotion", "regulation", "measures", "and", "then", "investigated", "the", "impact", "of", "alexithymia", "on", "attrition", "and", "alcohol", "treatment", "outcomes", "in", "men", "and", "women", "(", "N=77", ")", "enrolled", "in", "a", "12-week", "cognitive", "-", "behavioral", "intervention", "for", "alcohol", "dependence", ".", "At", "baseline", ",", "higher", "scores", "on", "alexithymia", "were", "associated", "poorer", "emotion", "regulation", "skills", ",", "fewer", "percent", "days", "abstinent", ",", "greater", "alcohol", "dependence", "severity", ",", "and", "several", "high", "-", "risk", "drinking", "situations", ".", "Alexithymia", "was", "unrelated", "to", "attrition", "and", "to", "level", "of", "alcohol", "consumption", "at", "posttreatment", ".", "Overall", ",", "the", "construct", "of", "alexithymia", "is", "shown", "to", "be", "related", "to", "several", "theoretically", "-", "related", "constructs", "(", "e.g", ".", ",", "emotion", "regulation", ",", "mindfulness", ")", "but", "demonstrated", "a", "limited", "relationship", "to", "drinking", "outcomes", "in", "those", "seeking", "treatment", "for", "alcohol", "dependence", "." ]	[ "Intervention_Psychological", "Participant_Condition", "Outcome_Mental", "Intervention_Other" ]
Risikofaktoren is an umlsterm, Faehigkeit is an umlsterm, Leistungen is an umlsterm, Beurteilung is an umlsterm, geschulten is an umlsterm, Aerzten is an umlsterm	DerOrthopaede.80270846.ger.abstr_task0	Sentence: Voraussetzung fuer die neuropsychiatrische Begutachtung nach Beschleunigungsverletzung der HWS sind die genaue Kenntnis der Symptome und Risikofaktoren eines verzoegerten Heilverlaufs sowie die Faehigkeit zur Evaluation des Schmerzerlebens und des Krankheitsverhaltens bzw. der kognitiven Leistungen . Diese Kenntnisse ermoeglichen eine integrative Beurteilung , welche vorzugsweise von Psychiatern oder psychosomatisch geschulten Aerzten uebernommen werden soll . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O" ]	Voraussetzung fuer die neuropsychiatrische Begutachtung nach Beschleunigungsverletzung der HWS sind die genaue Kenntnis der Symptome und Risikofaktoren eines verzoegerten Heilverlaufs sowie die Faehigkeit zur Evaluation des Schmerzerlebens und des Krankheitsverhaltens bzw. der kognitiven Leistungen . Diese Kenntnisse ermoeglichen eine integrative Beurteilung , welche vorzugsweise von Psychiatern oder psychosomatisch geschulten Aerzten uebernommen werden soll .	[ "Voraussetzung", "fuer", "die", "neuropsychiatrische", "Begutachtung", "nach", "Beschleunigungsverletzung", "der", "HWS", "sind", "die", "genaue", "Kenntnis", "der", "Symptome", "und", "Risikofaktoren", "eines", "verzoegerten", "Heilverlaufs", "sowie", "die", "Faehigkeit", "zur", "Evaluation", "des", "Schmerzerlebens", "und", "des", "Krankheitsverhaltens", "bzw", ".", "der", "kognitiven", "Leistungen", ".", "Diese", "Kenntnisse", "ermoeglichen", "eine", "integrative", "Beurteilung", ",", "welche", "vorzugsweise", "von", "Psychiatern", "oder", "psychosomatisch", "geschulten", "Aerzten", "uebernommen", "werden", "soll", "." ]	[ "umlsterm" ]
Risikofaktoren is an umlsterm, Faehigkeit is an umlsterm, Leistungen is an umlsterm, Beurteilung is an umlsterm, geschulten is an umlsterm, Aerzten is an umlsterm	DerOrthopaede.80270846.ger.abstr_task1	Sentence: Voraussetzung fuer die neuropsychiatrische Begutachtung nach Beschleunigungsverletzung der HWS sind die genaue Kenntnis der Symptome und Risikofaktoren eines verzoegerten Heilverlaufs sowie die Faehigkeit zur Evaluation des Schmerzerlebens und des Krankheitsverhaltens bzw. der kognitiven Leistungen . Diese Kenntnisse ermoeglichen eine integrative Beurteilung , welche vorzugsweise von Psychiatern oder psychosomatisch geschulten Aerzten uebernommen werden soll . Instructions: please typing these entity words according to sentence: Risikofaktoren, Faehigkeit, Leistungen, Beurteilung, geschulten, Aerzten Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O" ]	Voraussetzung fuer die neuropsychiatrische Begutachtung nach Beschleunigungsverletzung der HWS sind die genaue Kenntnis der Symptome und Risikofaktoren eines verzoegerten Heilverlaufs sowie die Faehigkeit zur Evaluation des Schmerzerlebens und des Krankheitsverhaltens bzw. der kognitiven Leistungen . Diese Kenntnisse ermoeglichen eine integrative Beurteilung , welche vorzugsweise von Psychiatern oder psychosomatisch geschulten Aerzten uebernommen werden soll .	[ "Voraussetzung", "fuer", "die", "neuropsychiatrische", "Begutachtung", "nach", "Beschleunigungsverletzung", "der", "HWS", "sind", "die", "genaue", "Kenntnis", "der", "Symptome", "und", "Risikofaktoren", "eines", "verzoegerten", "Heilverlaufs", "sowie", "die", "Faehigkeit", "zur", "Evaluation", "des", "Schmerzerlebens", "und", "des", "Krankheitsverhaltens", "bzw", ".", "der", "kognitiven", "Leistungen", ".", "Diese", "Kenntnisse", "ermoeglichen", "eine", "integrative", "Beurteilung", ",", "welche", "vorzugsweise", "von", "Psychiatern", "oder", "psychosomatisch", "geschulten", "Aerzten", "uebernommen", "werden", "soll", "." ]	[ "umlsterm" ]
Risikofaktoren, Faehigkeit, Leistungen, Beurteilung, geschulten, Aerzten	DerOrthopaede.80270846.ger.abstr_task2	Sentence: Voraussetzung fuer die neuropsychiatrische Begutachtung nach Beschleunigungsverletzung der HWS sind die genaue Kenntnis der Symptome und Risikofaktoren eines verzoegerten Heilverlaufs sowie die Faehigkeit zur Evaluation des Schmerzerlebens und des Krankheitsverhaltens bzw. der kognitiven Leistungen . Diese Kenntnisse ermoeglichen eine integrative Beurteilung , welche vorzugsweise von Psychiatern oder psychosomatisch geschulten Aerzten uebernommen werden soll . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O" ]	Voraussetzung fuer die neuropsychiatrische Begutachtung nach Beschleunigungsverletzung der HWS sind die genaue Kenntnis der Symptome und Risikofaktoren eines verzoegerten Heilverlaufs sowie die Faehigkeit zur Evaluation des Schmerzerlebens und des Krankheitsverhaltens bzw. der kognitiven Leistungen . Diese Kenntnisse ermoeglichen eine integrative Beurteilung , welche vorzugsweise von Psychiatern oder psychosomatisch geschulten Aerzten uebernommen werden soll .	[ "Voraussetzung", "fuer", "die", "neuropsychiatrische", "Begutachtung", "nach", "Beschleunigungsverletzung", "der", "HWS", "sind", "die", "genaue", "Kenntnis", "der", "Symptome", "und", "Risikofaktoren", "eines", "verzoegerten", "Heilverlaufs", "sowie", "die", "Faehigkeit", "zur", "Evaluation", "des", "Schmerzerlebens", "und", "des", "Krankheitsverhaltens", "bzw", ".", "der", "kognitiven", "Leistungen", ".", "Diese", "Kenntnisse", "ermoeglichen", "eine", "integrative", "Beurteilung", ",", "welche", "vorzugsweise", "von", "Psychiatern", "oder", "psychosomatisch", "geschulten", "Aerzten", "uebernommen", "werden", "soll", "." ]	[ "umlsterm" ]
17beta - estradiol is a compound, Akt is a protein, GSK-3beta is a protein	DS.d815_task0	Sentence: Both 17alpha- and 17beta-estradiol elicited rapid phosphorylation of p42/44MAPK, Akt, and GSK-3beta within 8 min. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein	[ "O", "O", "O", "B-compound", "I-compound", "I-compound", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein", "O", "O", "O", "O" ]	Both 17alpha- and 17beta-estradiol elicited rapid phosphorylation of p42/44MAPK, Akt, and GSK-3beta within 8 min.	[ "Both", "17alpha-", "and", "17beta", "-", "estradiol", "elicited", "rapid", "phosphorylation", "of", "p42/44MAPK", ",", "Akt", ",", "and", "GSK-3beta", "within", "8", "min", "." ]	[ "compound", "protein" ]
17beta - estradiol is a compound, Akt is a protein, GSK-3beta is a protein	DS.d815_task1	Sentence: Both 17alpha- and 17beta-estradiol elicited rapid phosphorylation of p42/44MAPK, Akt, and GSK-3beta within 8 min. Instructions: please typing these entity words according to sentence: 17beta - estradiol, Akt, GSK-3beta Options: compound, protein	[ "O", "O", "O", "B-compound", "I-compound", "I-compound", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein", "O", "O", "O", "O" ]	Both 17alpha- and 17beta-estradiol elicited rapid phosphorylation of p42/44MAPK, Akt, and GSK-3beta within 8 min.	[ "Both", "17alpha-", "and", "17beta", "-", "estradiol", "elicited", "rapid", "phosphorylation", "of", "p42/44MAPK", ",", "Akt", ",", "and", "GSK-3beta", "within", "8", "min", "." ]	[ "compound", "protein" ]
17beta - estradiol, Akt, GSK-3beta	DS.d815_task2	Sentence: Both 17alpha- and 17beta-estradiol elicited rapid phosphorylation of p42/44MAPK, Akt, and GSK-3beta within 8 min. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-compound", "I-compound", "I-compound", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein", "O", "O", "O", "O" ]	Both 17alpha- and 17beta-estradiol elicited rapid phosphorylation of p42/44MAPK, Akt, and GSK-3beta within 8 min.	[ "Both", "17alpha-", "and", "17beta", "-", "estradiol", "elicited", "rapid", "phosphorylation", "of", "p42/44MAPK", ",", "Akt", ",", "and", "GSK-3beta", "within", "8", "min", "." ]	[ "compound", "protein" ]
Relaxing retinotomy with silicone oil or long - acting gas is a Intervention_Physical, proliferative vitreoretinopathy is a Outcome_Physical, 117 is a Participant_Sample-size, 404 is a Participant_Sample-size, vitrectomy is a Intervention_Pharmacological, relaxing retinotomy is a Intervention_Surgical, treatment with long - acting gas or silicone oil is a Intervention_Pharmacological, Forty - six is a Participant_Sample-size, better anatomic ( six months ) is a Outcome_Physical, visual ( six and 24 months ) outcomes is a Outcome_Physical, hypotony is a Outcome_Physical, perflouropropane is a Intervention_Pharmacological, equally effective is a Outcome_Other	84781_task0	Sentence: Relaxing retinotomy with silicone oil or long-acting gas in eyes with severe proliferative vitreoretinopathy . Silicone Study Report 5 . The Silicone Study Group . In the Silicone Study , 117 of 404 eyes ( 29 % ) with severe proliferative vitreoretinopathy ( > or = C-3 , full-thickness retinal folds in three or more quadrants ) enrolled in the study were treated with vitrectomy , underwent a relaxing retinotomy , and were randomly assigned to treatment with long-acting gas or silicone oil . Forty-six eyes ( 20 % ) had undergone no previous vitrectomy ( group 1 ) ; 71 eyes ( 42 % ) had undergone previous vitrectomy ( group 2 ) with intraocular gas tamponade ( P < .001 ) . Group 1 eyes not undergoing retinotomy had better anatomic ( six months ) and visual ( six and 24 months ) outcomes and less hypotony ( six months ) than eyes that did regardless of tamponade ( P < .05 ) . For eyes undergoing retinotomy , silicone oil decreased the likelihood of hypotony ( six months , P < .05 ) . These differences were not found in group 2 eyes . We conclude that eyes undergoing a vitreous operation for the first time for the treatment of proliferative vitreoretinopathy can in most instances be successfully treated by conventional techniques without the need for relaxing retinotomy . Retinotomy may be required more often in patients undergoing repeat vitreous surgery for proliferative vitreoretinopathy , in which case both silicone oil and long-acting perflouropropane gas appear to be equally effective . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Intervention_Physical, Outcome_Physical, Participant_Sample-size, Outcome_Other, Intervention_Surgical	[ "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "B-Intervention_Surgical", "I-Intervention_Surgical", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O" ]	Relaxing retinotomy with silicone oil or long-acting gas in eyes with severe proliferative vitreoretinopathy . Silicone Study Report 5 . The Silicone Study Group . In the Silicone Study , 117 of 404 eyes ( 29 % ) with severe proliferative vitreoretinopathy ( > or = C-3 , full-thickness retinal folds in three or more quadrants ) enrolled in the study were treated with vitrectomy , underwent a relaxing retinotomy , and were randomly assigned to treatment with long-acting gas or silicone oil . Forty-six eyes ( 20 % ) had undergone no previous vitrectomy ( group 1 ) ; 71 eyes ( 42 % ) had undergone previous vitrectomy ( group 2 ) with intraocular gas tamponade ( P < .001 ) . Group 1 eyes not undergoing retinotomy had better anatomic ( six months ) and visual ( six and 24 months ) outcomes and less hypotony ( six months ) than eyes that did regardless of tamponade ( P < .05 ) . For eyes undergoing retinotomy , silicone oil decreased the likelihood of hypotony ( six months , P < .05 ) . These differences were not found in group 2 eyes . We conclude that eyes undergoing a vitreous operation for the first time for the treatment of proliferative vitreoretinopathy can in most instances be successfully treated by conventional techniques without the need for relaxing retinotomy . Retinotomy may be required more often in patients undergoing repeat vitreous surgery for proliferative vitreoretinopathy , in which case both silicone oil and long-acting perflouropropane gas appear to be equally effective .	[ "Relaxing", "retinotomy", "with", "silicone", "oil", "or", "long", "-", "acting", "gas", "in", "eyes", "with", "severe", "proliferative", "vitreoretinopathy", ".", "Silicone", "Study", "Report", "5", ".", "The", "Silicone", "Study", "Group", ".", "In", "the", "Silicone", "Study", ",", "117", "of", "404", "eyes", "(", "29", "%", ")", "with", "severe", "proliferative", "vitreoretinopathy", "(", ">", "or", "=", "C-3", ",", "full", "-", "thickness", "retinal", "folds", "in", "three", "or", "more", "quadrants", ")", "enrolled", "in", "the", "study", "were", "treated", "with", "vitrectomy", ",", "underwent", "a", "relaxing", "retinotomy", ",", "and", "were", "randomly", "assigned", "to", "treatment", "with", "long", "-", "acting", "gas", "or", "silicone", "oil", ".", "Forty", "-", "six", "eyes", "(", "20", "%", ")", "had", "undergone", "no", "previous", "vitrectomy", "(", "group", "1", ")", ";", "71", "eyes", "(", "42", "%", ")", "had", "undergone", "previous", "vitrectomy", "(", "group", "2", ")", "with", "intraocular", "gas", "tamponade", "(", "P", "<", ".001", ")", ".", "Group", "1", "eyes", "not", "undergoing", "retinotomy", "had", "better", "anatomic", "(", "six", "months", ")", "and", "visual", "(", "six", "and", "24", "months", ")", "outcomes", "and", "less", "hypotony", "(", "six", "months", ")", "than", "eyes", "that", "did", "regardless", "of", "tamponade", "(", "P", "<", ".05", ")", ".", "For", "eyes", "undergoing", "retinotomy", ",", "silicone", "oil", "decreased", "the", "likelihood", "of", "hypotony", "(", "six", "months", ",", "P", "<", ".05", ")", ".", "These", "differences", "were", "not", "found", "in", "group", "2", "eyes", ".", "We", "conclude", "that", "eyes", "undergoing", "a", "vitreous", "operation", "for", "the", "first", "time", "for", "the", "treatment", "of", "proliferative", "vitreoretinopathy", "can", "in", "most", "instances", "be", "successfully", "treated", "by", "conventional", "techniques", "without", "the", "need", "for", "relaxing", "retinotomy", ".", "Retinotomy", "may", "be", "required", "more", "often", "in", "patients", "undergoing", "repeat", "vitreous", "surgery", "for", "proliferative", "vitreoretinopathy", ",", "in", "which", "case", "both", "silicone", "oil", "and", "long", "-", "acting", "perflouropropane", "gas", "appear", "to", "be", "equally", "effective", "." ]	[ "Intervention_Physical", "Intervention_Pharmacological", "Outcome_Physical", "Participant_Condition", "Intervention_Surgical", "Outcome_Other", "Participant_Sample-size" ]
Relaxing retinotomy with silicone oil or long - acting gas is a Intervention_Physical, proliferative vitreoretinopathy is a Outcome_Physical, 117 is a Participant_Sample-size, 404 is a Participant_Sample-size, vitrectomy is a Intervention_Pharmacological, relaxing retinotomy is a Intervention_Surgical, treatment with long - acting gas or silicone oil is a Intervention_Pharmacological, Forty - six is a Participant_Sample-size, better anatomic ( six months ) is a Outcome_Physical, visual ( six and 24 months ) outcomes is a Outcome_Physical, hypotony is a Outcome_Physical, perflouropropane is a Intervention_Pharmacological, equally effective is a Outcome_Other	84781_task1	Sentence: Relaxing retinotomy with silicone oil or long-acting gas in eyes with severe proliferative vitreoretinopathy . Silicone Study Report 5 . The Silicone Study Group . In the Silicone Study , 117 of 404 eyes ( 29 % ) with severe proliferative vitreoretinopathy ( > or = C-3 , full-thickness retinal folds in three or more quadrants ) enrolled in the study were treated with vitrectomy , underwent a relaxing retinotomy , and were randomly assigned to treatment with long-acting gas or silicone oil . Forty-six eyes ( 20 % ) had undergone no previous vitrectomy ( group 1 ) ; 71 eyes ( 42 % ) had undergone previous vitrectomy ( group 2 ) with intraocular gas tamponade ( P < .001 ) . Group 1 eyes not undergoing retinotomy had better anatomic ( six months ) and visual ( six and 24 months ) outcomes and less hypotony ( six months ) than eyes that did regardless of tamponade ( P < .05 ) . For eyes undergoing retinotomy , silicone oil decreased the likelihood of hypotony ( six months , P < .05 ) . These differences were not found in group 2 eyes . We conclude that eyes undergoing a vitreous operation for the first time for the treatment of proliferative vitreoretinopathy can in most instances be successfully treated by conventional techniques without the need for relaxing retinotomy . Retinotomy may be required more often in patients undergoing repeat vitreous surgery for proliferative vitreoretinopathy , in which case both silicone oil and long-acting perflouropropane gas appear to be equally effective . Instructions: please typing these entity words according to sentence: Relaxing retinotomy with silicone oil or long - acting gas, proliferative vitreoretinopathy, 117, 404, vitrectomy, relaxing retinotomy, treatment with long - acting gas or silicone oil, Forty - six, better anatomic ( six months ), visual ( six and 24 months ) outcomes, hypotony, perflouropropane, equally effective Options: Intervention_Pharmacological, Intervention_Physical, Outcome_Physical, Participant_Sample-size, Outcome_Other, Intervention_Surgical	[ "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "B-Intervention_Surgical", "I-Intervention_Surgical", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O" ]	Relaxing retinotomy with silicone oil or long-acting gas in eyes with severe proliferative vitreoretinopathy . Silicone Study Report 5 . The Silicone Study Group . In the Silicone Study , 117 of 404 eyes ( 29 % ) with severe proliferative vitreoretinopathy ( > or = C-3 , full-thickness retinal folds in three or more quadrants ) enrolled in the study were treated with vitrectomy , underwent a relaxing retinotomy , and were randomly assigned to treatment with long-acting gas or silicone oil . Forty-six eyes ( 20 % ) had undergone no previous vitrectomy ( group 1 ) ; 71 eyes ( 42 % ) had undergone previous vitrectomy ( group 2 ) with intraocular gas tamponade ( P < .001 ) . Group 1 eyes not undergoing retinotomy had better anatomic ( six months ) and visual ( six and 24 months ) outcomes and less hypotony ( six months ) than eyes that did regardless of tamponade ( P < .05 ) . For eyes undergoing retinotomy , silicone oil decreased the likelihood of hypotony ( six months , P < .05 ) . These differences were not found in group 2 eyes . We conclude that eyes undergoing a vitreous operation for the first time for the treatment of proliferative vitreoretinopathy can in most instances be successfully treated by conventional techniques without the need for relaxing retinotomy . Retinotomy may be required more often in patients undergoing repeat vitreous surgery for proliferative vitreoretinopathy , in which case both silicone oil and long-acting perflouropropane gas appear to be equally effective .	[ "Relaxing", "retinotomy", "with", "silicone", "oil", "or", "long", "-", "acting", "gas", "in", "eyes", "with", "severe", "proliferative", "vitreoretinopathy", ".", "Silicone", "Study", "Report", "5", ".", "The", "Silicone", "Study", "Group", ".", "In", "the", "Silicone", "Study", ",", "117", "of", "404", "eyes", "(", "29", "%", ")", "with", "severe", "proliferative", "vitreoretinopathy", "(", ">", "or", "=", "C-3", ",", "full", "-", "thickness", "retinal", "folds", "in", "three", "or", "more", "quadrants", ")", "enrolled", "in", "the", "study", "were", "treated", "with", "vitrectomy", ",", "underwent", "a", "relaxing", "retinotomy", ",", "and", "were", "randomly", "assigned", "to", "treatment", "with", "long", "-", "acting", "gas", "or", "silicone", "oil", ".", "Forty", "-", "six", "eyes", "(", "20", "%", ")", "had", "undergone", "no", "previous", "vitrectomy", "(", "group", "1", ")", ";", "71", "eyes", "(", "42", "%", ")", "had", "undergone", "previous", "vitrectomy", "(", "group", "2", ")", "with", "intraocular", "gas", "tamponade", "(", "P", "<", ".001", ")", ".", "Group", "1", "eyes", "not", "undergoing", "retinotomy", "had", "better", "anatomic", "(", "six", "months", ")", "and", "visual", "(", "six", "and", "24", "months", ")", "outcomes", "and", "less", "hypotony", "(", "six", "months", ")", "than", "eyes", "that", "did", "regardless", "of", "tamponade", "(", "P", "<", ".05", ")", ".", "For", "eyes", "undergoing", "retinotomy", ",", "silicone", "oil", "decreased", "the", "likelihood", "of", "hypotony", "(", "six", "months", ",", "P", "<", ".05", ")", ".", "These", "differences", "were", "not", "found", "in", "group", "2", "eyes", ".", "We", "conclude", "that", "eyes", "undergoing", "a", "vitreous", "operation", "for", "the", "first", "time", "for", "the", "treatment", "of", "proliferative", "vitreoretinopathy", "can", "in", "most", "instances", "be", "successfully", "treated", "by", "conventional", "techniques", "without", "the", "need", "for", "relaxing", "retinotomy", ".", "Retinotomy", "may", "be", "required", "more", "often", "in", "patients", "undergoing", "repeat", "vitreous", "surgery", "for", "proliferative", "vitreoretinopathy", ",", "in", "which", "case", "both", "silicone", "oil", "and", "long", "-", "acting", "perflouropropane", "gas", "appear", "to", "be", "equally", "effective", "." ]	[ "Intervention_Physical", "Intervention_Pharmacological", "Outcome_Physical", "Participant_Condition", "Intervention_Surgical", "Outcome_Other", "Participant_Sample-size" ]
Relaxing retinotomy with silicone oil or long - acting gas, proliferative vitreoretinopathy, 117, 404, vitrectomy, relaxing retinotomy, treatment with long - acting gas or silicone oil, Forty - six, better anatomic ( six months ), visual ( six and 24 months ) outcomes, hypotony, perflouropropane, equally effective	84781_task2	Sentence: Relaxing retinotomy with silicone oil or long-acting gas in eyes with severe proliferative vitreoretinopathy . Silicone Study Report 5 . The Silicone Study Group . In the Silicone Study , 117 of 404 eyes ( 29 % ) with severe proliferative vitreoretinopathy ( > or = C-3 , full-thickness retinal folds in three or more quadrants ) enrolled in the study were treated with vitrectomy , underwent a relaxing retinotomy , and were randomly assigned to treatment with long-acting gas or silicone oil . Forty-six eyes ( 20 % ) had undergone no previous vitrectomy ( group 1 ) ; 71 eyes ( 42 % ) had undergone previous vitrectomy ( group 2 ) with intraocular gas tamponade ( P < .001 ) . Group 1 eyes not undergoing retinotomy had better anatomic ( six months ) and visual ( six and 24 months ) outcomes and less hypotony ( six months ) than eyes that did regardless of tamponade ( P < .05 ) . For eyes undergoing retinotomy , silicone oil decreased the likelihood of hypotony ( six months , P < .05 ) . These differences were not found in group 2 eyes . We conclude that eyes undergoing a vitreous operation for the first time for the treatment of proliferative vitreoretinopathy can in most instances be successfully treated by conventional techniques without the need for relaxing retinotomy . Retinotomy may be required more often in patients undergoing repeat vitreous surgery for proliferative vitreoretinopathy , in which case both silicone oil and long-acting perflouropropane gas appear to be equally effective . Instructions: please extract entity words from the input sentence	[ "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "B-Intervention_Surgical", "I-Intervention_Surgical", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O" ]	Relaxing retinotomy with silicone oil or long-acting gas in eyes with severe proliferative vitreoretinopathy . Silicone Study Report 5 . The Silicone Study Group . In the Silicone Study , 117 of 404 eyes ( 29 % ) with severe proliferative vitreoretinopathy ( > or = C-3 , full-thickness retinal folds in three or more quadrants ) enrolled in the study were treated with vitrectomy , underwent a relaxing retinotomy , and were randomly assigned to treatment with long-acting gas or silicone oil . Forty-six eyes ( 20 % ) had undergone no previous vitrectomy ( group 1 ) ; 71 eyes ( 42 % ) had undergone previous vitrectomy ( group 2 ) with intraocular gas tamponade ( P < .001 ) . Group 1 eyes not undergoing retinotomy had better anatomic ( six months ) and visual ( six and 24 months ) outcomes and less hypotony ( six months ) than eyes that did regardless of tamponade ( P < .05 ) . For eyes undergoing retinotomy , silicone oil decreased the likelihood of hypotony ( six months , P < .05 ) . These differences were not found in group 2 eyes . We conclude that eyes undergoing a vitreous operation for the first time for the treatment of proliferative vitreoretinopathy can in most instances be successfully treated by conventional techniques without the need for relaxing retinotomy . Retinotomy may be required more often in patients undergoing repeat vitreous surgery for proliferative vitreoretinopathy , in which case both silicone oil and long-acting perflouropropane gas appear to be equally effective .	[ "Relaxing", "retinotomy", "with", "silicone", "oil", "or", "long", "-", "acting", "gas", "in", "eyes", "with", "severe", "proliferative", "vitreoretinopathy", ".", "Silicone", "Study", "Report", "5", ".", "The", "Silicone", "Study", "Group", ".", "In", "the", "Silicone", "Study", ",", "117", "of", "404", "eyes", "(", "29", "%", ")", "with", "severe", "proliferative", "vitreoretinopathy", "(", ">", "or", "=", "C-3", ",", "full", "-", "thickness", "retinal", "folds", "in", "three", "or", "more", "quadrants", ")", "enrolled", "in", "the", "study", "were", "treated", "with", "vitrectomy", ",", "underwent", "a", "relaxing", "retinotomy", ",", "and", "were", "randomly", "assigned", "to", "treatment", "with", "long", "-", "acting", "gas", "or", "silicone", "oil", ".", "Forty", "-", "six", "eyes", "(", "20", "%", ")", "had", "undergone", "no", "previous", "vitrectomy", "(", "group", "1", ")", ";", "71", "eyes", "(", "42", "%", ")", "had", "undergone", "previous", "vitrectomy", "(", "group", "2", ")", "with", "intraocular", "gas", "tamponade", "(", "P", "<", ".001", ")", ".", "Group", "1", "eyes", "not", "undergoing", "retinotomy", "had", "better", "anatomic", "(", "six", "months", ")", "and", "visual", "(", "six", "and", "24", "months", ")", "outcomes", "and", "less", "hypotony", "(", "six", "months", ")", "than", "eyes", "that", "did", "regardless", "of", "tamponade", "(", "P", "<", ".05", ")", ".", "For", "eyes", "undergoing", "retinotomy", ",", "silicone", "oil", "decreased", "the", "likelihood", "of", "hypotony", "(", "six", "months", ",", "P", "<", ".05", ")", ".", "These", "differences", "were", "not", "found", "in", "group", "2", "eyes", ".", "We", "conclude", "that", "eyes", "undergoing", "a", "vitreous", "operation", "for", "the", "first", "time", "for", "the", "treatment", "of", "proliferative", "vitreoretinopathy", "can", "in", "most", "instances", "be", "successfully", "treated", "by", "conventional", "techniques", "without", "the", "need", "for", "relaxing", "retinotomy", ".", "Retinotomy", "may", "be", "required", "more", "often", "in", "patients", "undergoing", "repeat", "vitreous", "surgery", "for", "proliferative", "vitreoretinopathy", ",", "in", "which", "case", "both", "silicone", "oil", "and", "long", "-", "acting", "perflouropropane", "gas", "appear", "to", "be", "equally", "effective", "." ]	[ "Intervention_Physical", "Intervention_Pharmacological", "Outcome_Physical", "Participant_Condition", "Intervention_Surgical", "Outcome_Other", "Participant_Sample-size" ]
dihydroergotamine is a CHEMICAL, 5-HT2B is a GENE-Y, 5-HT2C is a GENE-Y	12970106_task0	Sentence: Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, CHEMICAL	[ "O", "O", "O", "B-CHEMICAL", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy.	[ "Agonist", "actions", "of", "dihydroergotamine", "at", "5-HT2B", "and", "5-HT2C", "receptors", "and", "their", "possible", "relevance", "to", "antimigraine", "efficacy", "." ]	[ "CHEMICAL", "GENE-N", "GENE-Y" ]
dihydroergotamine is a CHEMICAL, 5-HT2B is a GENE-Y, 5-HT2C is a GENE-Y	12970106_task1	Sentence: Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy. Instructions: please typing these entity words according to sentence: dihydroergotamine, 5-HT2B, 5-HT2C Options: GENE-Y, CHEMICAL	[ "O", "O", "O", "B-CHEMICAL", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy.	[ "Agonist", "actions", "of", "dihydroergotamine", "at", "5-HT2B", "and", "5-HT2C", "receptors", "and", "their", "possible", "relevance", "to", "antimigraine", "efficacy", "." ]	[ "CHEMICAL", "GENE-N", "GENE-Y" ]
dihydroergotamine, 5-HT2B, 5-HT2C	12970106_task2	Sentence: Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-CHEMICAL", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy.	[ "Agonist", "actions", "of", "dihydroergotamine", "at", "5-HT2B", "and", "5-HT2C", "receptors", "and", "their", "possible", "relevance", "to", "antimigraine", "efficacy", "." ]	[ "CHEMICAL", "GENE-N", "GENE-Y" ]
guanine nucleotide is a Entity, p21ras is a Protein, p21ras is a Protein, p21ras is a Protein, GTP is a Entity, p21ras is a Protein, p21ras is a Protein, p21ras is a Protein, GDP is a Entity, / GTP is a Entity, cysteine residue is a Entity, p21ras is a Protein, NF - kappa B is a Entity, p21ras is a Protein, p21ras is a Protein, p21ras is a Protein, p21ras is a Protein	169_task0	Sentence: Nitric oxide-stimulated guanine nucleotide exchange on p21ras. The protooncogene p21ras, a monomeric G protein family member, plays a critical role in converting extracellular signals into intracellular biochemical events. Here, we report that nitric oxide (NO) activates p21ras in human T cells as evidenced by an increase in GTP-bound p21ras. In vitro studies using pure recombinant p21ras demonstrate that the activation is direct and reversible. Circular dichroism analysis reveals that NO induces a profound conformational change in p21ras in association with GDP/GTP exchange. The mechanism of activation is due to S-nitrosylation of a critical cysteine residue which stimulates guanine nucleotide exchange. Furthermore, we demonstrate that p21ras is essential for NO-induced downstream signaling, such as NF-kappa B activation, and that endogenous NO can activate p21ras in the same cell. These studies identify p21ras as a target of the same cell. These studies identify p21ras as a target of NO in T cells and suggest that NO activates p21ras by an action which mimics that of guanine nucleotide exchange factors. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Entity, Protein	[ "O", "O", "O", "O", "B-Entity", "I-Entity", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "B-Entity", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Nitric oxide-stimulated guanine nucleotide exchange on p21ras. The protooncogene p21ras, a monomeric G protein family member, plays a critical role in converting extracellular signals into intracellular biochemical events. Here, we report that nitric oxide (NO) activates p21ras in human T cells as evidenced by an increase in GTP-bound p21ras. In vitro studies using pure recombinant p21ras demonstrate that the activation is direct and reversible. Circular dichroism analysis reveals that NO induces a profound conformational change in p21ras in association with GDP/GTP exchange. The mechanism of activation is due to S-nitrosylation of a critical cysteine residue which stimulates guanine nucleotide exchange. Furthermore, we demonstrate that p21ras is essential for NO-induced downstream signaling, such as NF-kappa B activation, and that endogenous NO can activate p21ras in the same cell. These studies identify p21ras as a target of the same cell. These studies identify p21ras as a target of NO in T cells and suggest that NO activates p21ras by an action which mimics that of guanine nucleotide exchange factors.	[ "Nitric", "oxide", "-", "stimulated", "guanine", "nucleotide", "exchange", "on", "p21ras", ".", "\n", "The", "protooncogene", "p21ras", ",", "a", "monomeric", "G", "protein", "family", "member", ",", "plays", "a", "critical", "role", "in", "converting", "extracellular", "signals", "into", "intracellular", "biochemical", "events", ".", "Here", ",", "we", "report", "that", "nitric", "oxide", "(", "NO", ")", "activates", "p21ras", "in", "human", "T", "cells", "as", "evidenced", "by", "an", "increase", "in", "GTP", "-", "bound", "p21ras", ".", "In", "vitro", "studies", "using", "pure", "recombinant", "p21ras", "demonstrate", "that", "the", "activation", "is", "direct", "and", "reversible", ".", "Circular", "dichroism", "analysis", "reveals", "that", "NO", "induces", "a", "profound", "conformational", "change", "in", "p21ras", "in", "association", "with", "GDP", "/", "GTP", "exchange", ".", "The", "mechanism", "of", "activation", "is", "due", "to", "S", "-", "nitrosylation", "of", "a", "critical", "cysteine", "residue", "which", "stimulates", "guanine", "nucleotide", "exchange", ".", "Furthermore", ",", "we", "demonstrate", "that", "p21ras", "is", "essential", "for", "NO", "-", "induced", "downstream", "signaling", ",", "such", "as", "NF", "-", "kappa", "B", "activation", ",", "and", "that", "endogenous", "NO", "can", "activate", "p21ras", "in", "the", "same", "cell", ".", "These", "studies", "identify", "p21ras", "as", "a", "target", "of", "the", "same", "cell", ".", "These", "studies", "identify", "p21ras", "as", "a", "target", "of", "NO", "in", "T", "cells", "and", "suggest", "that", "NO", "activates", "p21ras", "by", "an", "action", "which", "mimics", "that", "of", "guanine", "nucleotide", "exchange", "factors", ".", "\n" ]	[ "Entity", "Protein" ]
guanine nucleotide is a Entity, p21ras is a Protein, p21ras is a Protein, p21ras is a Protein, GTP is a Entity, p21ras is a Protein, p21ras is a Protein, p21ras is a Protein, GDP is a Entity, / GTP is a Entity, cysteine residue is a Entity, p21ras is a Protein, NF - kappa B is a Entity, p21ras is a Protein, p21ras is a Protein, p21ras is a Protein, p21ras is a Protein	169_task1	Sentence: Nitric oxide-stimulated guanine nucleotide exchange on p21ras. The protooncogene p21ras, a monomeric G protein family member, plays a critical role in converting extracellular signals into intracellular biochemical events. Here, we report that nitric oxide (NO) activates p21ras in human T cells as evidenced by an increase in GTP-bound p21ras. In vitro studies using pure recombinant p21ras demonstrate that the activation is direct and reversible. Circular dichroism analysis reveals that NO induces a profound conformational change in p21ras in association with GDP/GTP exchange. The mechanism of activation is due to S-nitrosylation of a critical cysteine residue which stimulates guanine nucleotide exchange. Furthermore, we demonstrate that p21ras is essential for NO-induced downstream signaling, such as NF-kappa B activation, and that endogenous NO can activate p21ras in the same cell. These studies identify p21ras as a target of the same cell. These studies identify p21ras as a target of NO in T cells and suggest that NO activates p21ras by an action which mimics that of guanine nucleotide exchange factors. Instructions: please typing these entity words according to sentence: guanine nucleotide, p21ras, p21ras, p21ras, GTP, p21ras, p21ras, p21ras, GDP, / GTP, cysteine residue, p21ras, NF - kappa B, p21ras, p21ras, p21ras, p21ras Options: Entity, Protein	[ "O", "O", "O", "O", "B-Entity", "I-Entity", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "B-Entity", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Nitric oxide-stimulated guanine nucleotide exchange on p21ras. The protooncogene p21ras, a monomeric G protein family member, plays a critical role in converting extracellular signals into intracellular biochemical events. Here, we report that nitric oxide (NO) activates p21ras in human T cells as evidenced by an increase in GTP-bound p21ras. In vitro studies using pure recombinant p21ras demonstrate that the activation is direct and reversible. Circular dichroism analysis reveals that NO induces a profound conformational change in p21ras in association with GDP/GTP exchange. The mechanism of activation is due to S-nitrosylation of a critical cysteine residue which stimulates guanine nucleotide exchange. Furthermore, we demonstrate that p21ras is essential for NO-induced downstream signaling, such as NF-kappa B activation, and that endogenous NO can activate p21ras in the same cell. These studies identify p21ras as a target of the same cell. These studies identify p21ras as a target of NO in T cells and suggest that NO activates p21ras by an action which mimics that of guanine nucleotide exchange factors.	[ "Nitric", "oxide", "-", "stimulated", "guanine", "nucleotide", "exchange", "on", "p21ras", ".", "\n", "The", "protooncogene", "p21ras", ",", "a", "monomeric", "G", "protein", "family", "member", ",", "plays", "a", "critical", "role", "in", "converting", "extracellular", "signals", "into", "intracellular", "biochemical", "events", ".", "Here", ",", "we", "report", "that", "nitric", "oxide", "(", "NO", ")", "activates", "p21ras", "in", "human", "T", "cells", "as", "evidenced", "by", "an", "increase", "in", "GTP", "-", "bound", "p21ras", ".", "In", "vitro", "studies", "using", "pure", "recombinant", "p21ras", "demonstrate", "that", "the", "activation", "is", "direct", "and", "reversible", ".", "Circular", "dichroism", "analysis", "reveals", "that", "NO", "induces", "a", "profound", "conformational", "change", "in", "p21ras", "in", "association", "with", "GDP", "/", "GTP", "exchange", ".", "The", "mechanism", "of", "activation", "is", "due", "to", "S", "-", "nitrosylation", "of", "a", "critical", "cysteine", "residue", "which", "stimulates", "guanine", "nucleotide", "exchange", ".", "Furthermore", ",", "we", "demonstrate", "that", "p21ras", "is", "essential", "for", "NO", "-", "induced", "downstream", "signaling", ",", "such", "as", "NF", "-", "kappa", "B", "activation", ",", "and", "that", "endogenous", "NO", "can", "activate", "p21ras", "in", "the", "same", "cell", ".", "These", "studies", "identify", "p21ras", "as", "a", "target", "of", "the", "same", "cell", ".", "These", "studies", "identify", "p21ras", "as", "a", "target", "of", "NO", "in", "T", "cells", "and", "suggest", "that", "NO", "activates", "p21ras", "by", "an", "action", "which", "mimics", "that", "of", "guanine", "nucleotide", "exchange", "factors", ".", "\n" ]	[ "Entity", "Protein" ]
guanine nucleotide, p21ras, p21ras, p21ras, GTP, p21ras, p21ras, p21ras, GDP, / GTP, cysteine residue, p21ras, NF - kappa B, p21ras, p21ras, p21ras, p21ras	169_task2	Sentence: Nitric oxide-stimulated guanine nucleotide exchange on p21ras. The protooncogene p21ras, a monomeric G protein family member, plays a critical role in converting extracellular signals into intracellular biochemical events. Here, we report that nitric oxide (NO) activates p21ras in human T cells as evidenced by an increase in GTP-bound p21ras. In vitro studies using pure recombinant p21ras demonstrate that the activation is direct and reversible. Circular dichroism analysis reveals that NO induces a profound conformational change in p21ras in association with GDP/GTP exchange. The mechanism of activation is due to S-nitrosylation of a critical cysteine residue which stimulates guanine nucleotide exchange. Furthermore, we demonstrate that p21ras is essential for NO-induced downstream signaling, such as NF-kappa B activation, and that endogenous NO can activate p21ras in the same cell. These studies identify p21ras as a target of the same cell. These studies identify p21ras as a target of NO in T cells and suggest that NO activates p21ras by an action which mimics that of guanine nucleotide exchange factors. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-Entity", "I-Entity", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "B-Entity", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Nitric oxide-stimulated guanine nucleotide exchange on p21ras. The protooncogene p21ras, a monomeric G protein family member, plays a critical role in converting extracellular signals into intracellular biochemical events. Here, we report that nitric oxide (NO) activates p21ras in human T cells as evidenced by an increase in GTP-bound p21ras. In vitro studies using pure recombinant p21ras demonstrate that the activation is direct and reversible. Circular dichroism analysis reveals that NO induces a profound conformational change in p21ras in association with GDP/GTP exchange. The mechanism of activation is due to S-nitrosylation of a critical cysteine residue which stimulates guanine nucleotide exchange. Furthermore, we demonstrate that p21ras is essential for NO-induced downstream signaling, such as NF-kappa B activation, and that endogenous NO can activate p21ras in the same cell. These studies identify p21ras as a target of the same cell. These studies identify p21ras as a target of NO in T cells and suggest that NO activates p21ras by an action which mimics that of guanine nucleotide exchange factors.	[ "Nitric", "oxide", "-", "stimulated", "guanine", "nucleotide", "exchange", "on", "p21ras", ".", "\n", "The", "protooncogene", "p21ras", ",", "a", "monomeric", "G", "protein", "family", "member", ",", "plays", "a", "critical", "role", "in", "converting", "extracellular", "signals", "into", "intracellular", "biochemical", "events", ".", "Here", ",", "we", "report", "that", "nitric", "oxide", "(", "NO", ")", "activates", "p21ras", "in", "human", "T", "cells", "as", "evidenced", "by", "an", "increase", "in", "GTP", "-", "bound", "p21ras", ".", "In", "vitro", "studies", "using", "pure", "recombinant", "p21ras", "demonstrate", "that", "the", "activation", "is", "direct", "and", "reversible", ".", "Circular", "dichroism", "analysis", "reveals", "that", "NO", "induces", "a", "profound", "conformational", "change", "in", "p21ras", "in", "association", "with", "GDP", "/", "GTP", "exchange", ".", "The", "mechanism", "of", "activation", "is", "due", "to", "S", "-", "nitrosylation", "of", "a", "critical", "cysteine", "residue", "which", "stimulates", "guanine", "nucleotide", "exchange", ".", "Furthermore", ",", "we", "demonstrate", "that", "p21ras", "is", "essential", "for", "NO", "-", "induced", "downstream", "signaling", ",", "such", "as", "NF", "-", "kappa", "B", "activation", ",", "and", "that", "endogenous", "NO", "can", "activate", "p21ras", "in", "the", "same", "cell", ".", "These", "studies", "identify", "p21ras", "as", "a", "target", "of", "the", "same", "cell", ".", "These", "studies", "identify", "p21ras", "as", "a", "target", "of", "NO", "in", "T", "cells", "and", "suggest", "that", "NO", "activates", "p21ras", "by", "an", "action", "which", "mimics", "that", "of", "guanine", "nucleotide", "exchange", "factors", ".", "\n" ]	[ "Entity", "Protein" ]
atresia is an umlsterm, perfusion is an umlsterm, blood is an umlsterm, ascending aorta is an umlsterm, patients is an umlsterm, ascending aorta is an umlsterm, atresia is an umlsterm, patient is an umlsterm, hypoplastic left heart is an umlsterm, syndrome is an umlsterm, atresia is an umlsterm, mitral stenosis is an umlsterm, foramen ovale is an umlsterm, angiography is an umlsterm, sole is an umlsterm, oxygenation is an umlsterm, patient is an umlsterm, congenital is an umlsterm, heart disease is an umlsterm, atresia is an umlsterm, ascending aorta is an umlsterm, fistula is an umlsterm, perfusion is an umlsterm, blood is an umlsterm, ascending aorta is an umlsterm, atresia is an umlsterm	ZfuerKardiologie.00890502.eng.abstr_task0	Sentence: In aortic atresia , coronary perfusion normally occurs through retrograde blood flow in the ascending aorta . We report on two patients with antegrade flow in the ascending aorta despite aortic atresia . In one patient with hypoplastic left heart syndrome ( aortic atresia , severe mitral stenosis ) , an intact interatrial septum/premature closure of the foramen ovale was found . While no other way of left atrial or ventricular decompression was found , echocardiography , angiography and the post-mortem examination showed left ventricular to coronary sinusoids as the sole pathway for systemic oxygenation . In a second patient with complex congenital heart disease , including aortic atresia , antegrade flow in the ascending aorta was through a left coronary fistula with shunt flow originating from the pulmonary trunc . This report describes systemic perfusion depending on retrograde coronary flow due to coronary-cameral ( sinusoids ) and coronary arterio-venous fistulas leading to the phenomenon of antegrade blood flow in the ascending aorta despite aortic atresia . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O" ]	In aortic atresia , coronary perfusion normally occurs through retrograde blood flow in the ascending aorta . We report on two patients with antegrade flow in the ascending aorta despite aortic atresia . In one patient with hypoplastic left heart syndrome ( aortic atresia , severe mitral stenosis ) , an intact interatrial septum/premature closure of the foramen ovale was found . While no other way of left atrial or ventricular decompression was found , echocardiography , angiography and the post-mortem examination showed left ventricular to coronary sinusoids as the sole pathway for systemic oxygenation . In a second patient with complex congenital heart disease , including aortic atresia , antegrade flow in the ascending aorta was through a left coronary fistula with shunt flow originating from the pulmonary trunc . This report describes systemic perfusion depending on retrograde coronary flow due to coronary-cameral ( sinusoids ) and coronary arterio-venous fistulas leading to the phenomenon of antegrade blood flow in the ascending aorta despite aortic atresia .	[ "In", "aortic", "atresia", ",", "coronary", "perfusion", "normally", "occurs", "through", "retrograde", "blood", "flow", "in", "the", "ascending", "aorta", ".", "We", "report", "on", "two", "patients", "with", "antegrade", "flow", "in", "the", "ascending", "aorta", "despite", "aortic", "atresia", ".", "In", "one", "patient", "with", "hypoplastic", "left", "heart", "syndrome", "(", "aortic", "atresia", ",", "severe", "mitral", "stenosis", ")", ",", "an", "intact", "interatrial", "septum", "/", "premature", "closure", "of", "the", "foramen", "ovale", "was", "found", ".", "While", "no", "other", "way", "of", "left", "atrial", "or", "ventricular", "decompression", "was", "found", ",", "echocardiography", ",", "angiography", "and", "the", "post", "-", "mortem", "examination", "showed", "left", "ventricular", "to", "coronary", "sinusoids", "as", "the", "sole", "pathway", "for", "systemic", "oxygenation", ".", "In", "a", "second", "patient", "with", "complex", "congenital", "heart", "disease", ",", "including", "aortic", "atresia", ",", "antegrade", "flow", "in", "the", "ascending", "aorta", "was", "through", "a", "left", "coronary", "fistula", "with", "shunt", "flow", "originating", "from", "the", "pulmonary", "trunc", ".", "This", "report", "describes", "systemic", "perfusion", "depending", "on", "retrograde", "coronary", "flow", "due", "to", "coronary", "-", "cameral", "(", "sinusoids", ")", "and", "coronary", "arterio", "-", "venous", "fistulas", "leading", "to", "the", "phenomenon", "of", "antegrade", "blood", "flow", "in", "the", "ascending", "aorta", "despite", "aortic", "atresia", "." ]	[ "umlsterm" ]
atresia is an umlsterm, perfusion is an umlsterm, blood is an umlsterm, ascending aorta is an umlsterm, patients is an umlsterm, ascending aorta is an umlsterm, atresia is an umlsterm, patient is an umlsterm, hypoplastic left heart is an umlsterm, syndrome is an umlsterm, atresia is an umlsterm, mitral stenosis is an umlsterm, foramen ovale is an umlsterm, angiography is an umlsterm, sole is an umlsterm, oxygenation is an umlsterm, patient is an umlsterm, congenital is an umlsterm, heart disease is an umlsterm, atresia is an umlsterm, ascending aorta is an umlsterm, fistula is an umlsterm, perfusion is an umlsterm, blood is an umlsterm, ascending aorta is an umlsterm, atresia is an umlsterm	ZfuerKardiologie.00890502.eng.abstr_task1	Sentence: In aortic atresia , coronary perfusion normally occurs through retrograde blood flow in the ascending aorta . We report on two patients with antegrade flow in the ascending aorta despite aortic atresia . In one patient with hypoplastic left heart syndrome ( aortic atresia , severe mitral stenosis ) , an intact interatrial septum/premature closure of the foramen ovale was found . While no other way of left atrial or ventricular decompression was found , echocardiography , angiography and the post-mortem examination showed left ventricular to coronary sinusoids as the sole pathway for systemic oxygenation . In a second patient with complex congenital heart disease , including aortic atresia , antegrade flow in the ascending aorta was through a left coronary fistula with shunt flow originating from the pulmonary trunc . This report describes systemic perfusion depending on retrograde coronary flow due to coronary-cameral ( sinusoids ) and coronary arterio-venous fistulas leading to the phenomenon of antegrade blood flow in the ascending aorta despite aortic atresia . Instructions: please typing these entity words according to sentence: atresia, perfusion, blood, ascending aorta, patients, ascending aorta, atresia, patient, hypoplastic left heart, syndrome, atresia, mitral stenosis, foramen ovale, angiography, sole, oxygenation, patient, congenital, heart disease, atresia, ascending aorta, fistula, perfusion, blood, ascending aorta, atresia Options: umlsterm	[ "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O" ]	In aortic atresia , coronary perfusion normally occurs through retrograde blood flow in the ascending aorta . We report on two patients with antegrade flow in the ascending aorta despite aortic atresia . In one patient with hypoplastic left heart syndrome ( aortic atresia , severe mitral stenosis ) , an intact interatrial septum/premature closure of the foramen ovale was found . While no other way of left atrial or ventricular decompression was found , echocardiography , angiography and the post-mortem examination showed left ventricular to coronary sinusoids as the sole pathway for systemic oxygenation . In a second patient with complex congenital heart disease , including aortic atresia , antegrade flow in the ascending aorta was through a left coronary fistula with shunt flow originating from the pulmonary trunc . This report describes systemic perfusion depending on retrograde coronary flow due to coronary-cameral ( sinusoids ) and coronary arterio-venous fistulas leading to the phenomenon of antegrade blood flow in the ascending aorta despite aortic atresia .	[ "In", "aortic", "atresia", ",", "coronary", "perfusion", "normally", "occurs", "through", "retrograde", "blood", "flow", "in", "the", "ascending", "aorta", ".", "We", "report", "on", "two", "patients", "with", "antegrade", "flow", "in", "the", "ascending", "aorta", "despite", "aortic", "atresia", ".", "In", "one", "patient", "with", "hypoplastic", "left", "heart", "syndrome", "(", "aortic", "atresia", ",", "severe", "mitral", "stenosis", ")", ",", "an", "intact", "interatrial", "septum", "/", "premature", "closure", "of", "the", "foramen", "ovale", "was", "found", ".", "While", "no", "other", "way", "of", "left", "atrial", "or", "ventricular", "decompression", "was", "found", ",", "echocardiography", ",", "angiography", "and", "the", "post", "-", "mortem", "examination", "showed", "left", "ventricular", "to", "coronary", "sinusoids", "as", "the", "sole", "pathway", "for", "systemic", "oxygenation", ".", "In", "a", "second", "patient", "with", "complex", "congenital", "heart", "disease", ",", "including", "aortic", "atresia", ",", "antegrade", "flow", "in", "the", "ascending", "aorta", "was", "through", "a", "left", "coronary", "fistula", "with", "shunt", "flow", "originating", "from", "the", "pulmonary", "trunc", ".", "This", "report", "describes", "systemic", "perfusion", "depending", "on", "retrograde", "coronary", "flow", "due", "to", "coronary", "-", "cameral", "(", "sinusoids", ")", "and", "coronary", "arterio", "-", "venous", "fistulas", "leading", "to", "the", "phenomenon", "of", "antegrade", "blood", "flow", "in", "the", "ascending", "aorta", "despite", "aortic", "atresia", "." ]	[ "umlsterm" ]
atresia, perfusion, blood, ascending aorta, patients, ascending aorta, atresia, patient, hypoplastic left heart, syndrome, atresia, mitral stenosis, foramen ovale, angiography, sole, oxygenation, patient, congenital, heart disease, atresia, ascending aorta, fistula, perfusion, blood, ascending aorta, atresia	ZfuerKardiologie.00890502.eng.abstr_task2	Sentence: In aortic atresia , coronary perfusion normally occurs through retrograde blood flow in the ascending aorta . We report on two patients with antegrade flow in the ascending aorta despite aortic atresia . In one patient with hypoplastic left heart syndrome ( aortic atresia , severe mitral stenosis ) , an intact interatrial septum/premature closure of the foramen ovale was found . While no other way of left atrial or ventricular decompression was found , echocardiography , angiography and the post-mortem examination showed left ventricular to coronary sinusoids as the sole pathway for systemic oxygenation . In a second patient with complex congenital heart disease , including aortic atresia , antegrade flow in the ascending aorta was through a left coronary fistula with shunt flow originating from the pulmonary trunc . This report describes systemic perfusion depending on retrograde coronary flow due to coronary-cameral ( sinusoids ) and coronary arterio-venous fistulas leading to the phenomenon of antegrade blood flow in the ascending aorta despite aortic atresia . Instructions: please extract entity words from the input sentence	[ "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O" ]	In aortic atresia , coronary perfusion normally occurs through retrograde blood flow in the ascending aorta . We report on two patients with antegrade flow in the ascending aorta despite aortic atresia . In one patient with hypoplastic left heart syndrome ( aortic atresia , severe mitral stenosis ) , an intact interatrial septum/premature closure of the foramen ovale was found . While no other way of left atrial or ventricular decompression was found , echocardiography , angiography and the post-mortem examination showed left ventricular to coronary sinusoids as the sole pathway for systemic oxygenation . In a second patient with complex congenital heart disease , including aortic atresia , antegrade flow in the ascending aorta was through a left coronary fistula with shunt flow originating from the pulmonary trunc . This report describes systemic perfusion depending on retrograde coronary flow due to coronary-cameral ( sinusoids ) and coronary arterio-venous fistulas leading to the phenomenon of antegrade blood flow in the ascending aorta despite aortic atresia .	[ "In", "aortic", "atresia", ",", "coronary", "perfusion", "normally", "occurs", "through", "retrograde", "blood", "flow", "in", "the", "ascending", "aorta", ".", "We", "report", "on", "two", "patients", "with", "antegrade", "flow", "in", "the", "ascending", "aorta", "despite", "aortic", "atresia", ".", "In", "one", "patient", "with", "hypoplastic", "left", "heart", "syndrome", "(", "aortic", "atresia", ",", "severe", "mitral", "stenosis", ")", ",", "an", "intact", "interatrial", "septum", "/", "premature", "closure", "of", "the", "foramen", "ovale", "was", "found", ".", "While", "no", "other", "way", "of", "left", "atrial", "or", "ventricular", "decompression", "was", "found", ",", "echocardiography", ",", "angiography", "and", "the", "post", "-", "mortem", "examination", "showed", "left", "ventricular", "to", "coronary", "sinusoids", "as", "the", "sole", "pathway", "for", "systemic", "oxygenation", ".", "In", "a", "second", "patient", "with", "complex", "congenital", "heart", "disease", ",", "including", "aortic", "atresia", ",", "antegrade", "flow", "in", "the", "ascending", "aorta", "was", "through", "a", "left", "coronary", "fistula", "with", "shunt", "flow", "originating", "from", "the", "pulmonary", "trunc", ".", "This", "report", "describes", "systemic", "perfusion", "depending", "on", "retrograde", "coronary", "flow", "due", "to", "coronary", "-", "cameral", "(", "sinusoids", ")", "and", "coronary", "arterio", "-", "venous", "fistulas", "leading", "to", "the", "phenomenon", "of", "antegrade", "blood", "flow", "in", "the", "ascending", "aorta", "despite", "aortic", "atresia", "." ]	[ "umlsterm" ]
aversive stimulation and failure is a Intervention_Physical, aversive stimulus and simultaneous failure on a bogus intelligence test is a Intervention_Physical, aggressive reactions is a Outcome_Mental, subject ' s fist clenching is a Participant_Condition, indicator of aggression is a Outcome_Mental, aversive or nonaversive is a Intervention_Physical, aversive or nonaversive acoustic signal is a Intervention_Physical, autonomic arousal , is a Outcome_Mental, speed of clenching is a Outcome_Mental, tendencies to aggression is a Outcome_Mental	3472_task0	Sentence: Human motor responses to simultaneous aversive stimulation and failure on a valued task . The effects of presentation of an aversive stimulus and simultaneous failure on a bogus intelligence test upon a subject 's aggressive reactions were studied . The subject 's fist clenching was used as an indicator of aggression . Four conditions , generated by the combinations of two kinds of stimulus delivered to the subjects ( aversive or nonaversive ) and two outcomes of the task ( failure or success ) , were investigated . 20 female and 20 male students ( ages : 17-34 years ) were instructed , upon the reception of an aversive or nonaversive acoustic signal , to press with the right hand a device that displayed a slide . Each slide presented an item from an intelligence test , to which the subjects were either allowed to answer successfully ( success ) or not ( failure ) . Failure increased the subject 's autonomic arousal , as measured by photoplethysmographic sensors , in all stimulation conditions , but only the condition with aversive stimulation increased the speed of clenching . This was interpreted as indicating subject 's tendencies to aggression . These results are discussed in relation to the effects of frustration . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Physical, Participant_Condition, Outcome_Mental	[ "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Human motor responses to simultaneous aversive stimulation and failure on a valued task . The effects of presentation of an aversive stimulus and simultaneous failure on a bogus intelligence test upon a subject 's aggressive reactions were studied . The subject 's fist clenching was used as an indicator of aggression . Four conditions , generated by the combinations of two kinds of stimulus delivered to the subjects ( aversive or nonaversive ) and two outcomes of the task ( failure or success ) , were investigated . 20 female and 20 male students ( ages : 17-34 years ) were instructed , upon the reception of an aversive or nonaversive acoustic signal , to press with the right hand a device that displayed a slide . Each slide presented an item from an intelligence test , to which the subjects were either allowed to answer successfully ( success ) or not ( failure ) . Failure increased the subject 's autonomic arousal , as measured by photoplethysmographic sensors , in all stimulation conditions , but only the condition with aversive stimulation increased the speed of clenching . This was interpreted as indicating subject 's tendencies to aggression . These results are discussed in relation to the effects of frustration .	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aversive stimulation and failure is a Intervention_Physical, aversive stimulus and simultaneous failure on a bogus intelligence test is a Intervention_Physical, aggressive reactions is a Outcome_Mental, subject ' s fist clenching is a Participant_Condition, indicator of aggression is a Outcome_Mental, aversive or nonaversive is a Intervention_Physical, aversive or nonaversive acoustic signal is a Intervention_Physical, autonomic arousal , is a Outcome_Mental, speed of clenching is a Outcome_Mental, tendencies to aggression is a Outcome_Mental	3472_task1	Sentence: Human motor responses to simultaneous aversive stimulation and failure on a valued task . The effects of presentation of an aversive stimulus and simultaneous failure on a bogus intelligence test upon a subject 's aggressive reactions were studied . The subject 's fist clenching was used as an indicator of aggression . Four conditions , generated by the combinations of two kinds of stimulus delivered to the subjects ( aversive or nonaversive ) and two outcomes of the task ( failure or success ) , were investigated . 20 female and 20 male students ( ages : 17-34 years ) were instructed , upon the reception of an aversive or nonaversive acoustic signal , to press with the right hand a device that displayed a slide . Each slide presented an item from an intelligence test , to which the subjects were either allowed to answer successfully ( success ) or not ( failure ) . Failure increased the subject 's autonomic arousal , as measured by photoplethysmographic sensors , in all stimulation conditions , but only the condition with aversive stimulation increased the speed of clenching . This was interpreted as indicating subject 's tendencies to aggression . These results are discussed in relation to the effects of frustration . Instructions: please typing these entity words according to sentence: aversive stimulation and failure, aversive stimulus and simultaneous failure on a bogus intelligence test, aggressive reactions, subject ' s fist clenching, indicator of aggression, aversive or nonaversive, aversive or nonaversive acoustic signal, autonomic arousal ,, speed of clenching, tendencies to aggression Options: Intervention_Physical, Participant_Condition, Outcome_Mental	[ "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Human motor responses to simultaneous aversive stimulation and failure on a valued task . The effects of presentation of an aversive stimulus and simultaneous failure on a bogus intelligence test upon a subject 's aggressive reactions were studied . The subject 's fist clenching was used as an indicator of aggression . Four conditions , generated by the combinations of two kinds of stimulus delivered to the subjects ( aversive or nonaversive ) and two outcomes of the task ( failure or success ) , were investigated . 20 female and 20 male students ( ages : 17-34 years ) were instructed , upon the reception of an aversive or nonaversive acoustic signal , to press with the right hand a device that displayed a slide . Each slide presented an item from an intelligence test , to which the subjects were either allowed to answer successfully ( success ) or not ( failure ) . Failure increased the subject 's autonomic arousal , as measured by photoplethysmographic sensors , in all stimulation conditions , but only the condition with aversive stimulation increased the speed of clenching . This was interpreted as indicating subject 's tendencies to aggression . These results are discussed in relation to the effects of frustration .	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aversive stimulation and failure, aversive stimulus and simultaneous failure on a bogus intelligence test, aggressive reactions, subject ' s fist clenching, indicator of aggression, aversive or nonaversive, aversive or nonaversive acoustic signal, autonomic arousal ,, speed of clenching, tendencies to aggression	3472_task2	Sentence: Human motor responses to simultaneous aversive stimulation and failure on a valued task . The effects of presentation of an aversive stimulus and simultaneous failure on a bogus intelligence test upon a subject 's aggressive reactions were studied . The subject 's fist clenching was used as an indicator of aggression . Four conditions , generated by the combinations of two kinds of stimulus delivered to the subjects ( aversive or nonaversive ) and two outcomes of the task ( failure or success ) , were investigated . 20 female and 20 male students ( ages : 17-34 years ) were instructed , upon the reception of an aversive or nonaversive acoustic signal , to press with the right hand a device that displayed a slide . Each slide presented an item from an intelligence test , to which the subjects were either allowed to answer successfully ( success ) or not ( failure ) . Failure increased the subject 's autonomic arousal , as measured by photoplethysmographic sensors , in all stimulation conditions , but only the condition with aversive stimulation increased the speed of clenching . This was interpreted as indicating subject 's tendencies to aggression . These results are discussed in relation to the effects of frustration . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Human motor responses to simultaneous aversive stimulation and failure on a valued task . The effects of presentation of an aversive stimulus and simultaneous failure on a bogus intelligence test upon a subject 's aggressive reactions were studied . The subject 's fist clenching was used as an indicator of aggression . Four conditions , generated by the combinations of two kinds of stimulus delivered to the subjects ( aversive or nonaversive ) and two outcomes of the task ( failure or success ) , were investigated . 20 female and 20 male students ( ages : 17-34 years ) were instructed , upon the reception of an aversive or nonaversive acoustic signal , to press with the right hand a device that displayed a slide . Each slide presented an item from an intelligence test , to which the subjects were either allowed to answer successfully ( success ) or not ( failure ) . Failure increased the subject 's autonomic arousal , as measured by photoplethysmographic sensors , in all stimulation conditions , but only the condition with aversive stimulation increased the speed of clenching . This was interpreted as indicating subject 's tendencies to aggression . These results are discussed in relation to the effects of frustration .	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complicated UTI is a Condition, temperature > 38 ° C , loin tenderness is a Scope, conditions is a Condition, complicated infections is a Condition, renal diseases , patients with urinary catheter is a Scope, self - medication is a Qualifier, UU preparations is a Drug, z. B. Cystinol ® , Uvalysat ® , Arctuvan ® is a Scope, antibiotic is a Drug, last 7 days is a Temporal, UTI is a Condition, past 2 weeks is a Temporal, pyelonephritis is a Condition, contraindications for is a Mood, trial is a Qualifier, drugs is a Drug, serious is a Qualifier, diseases is a Condition	NCT03151603_exc_task0	Sentence: signs of complicated UTI (e. g. temperature > 38°C, loin tenderness) conditions that may lead to complicated infections (i.e. renal diseases, patients with urinary catheter) pregnancy/ breastfeeding current self-medication with UU preparations e.g. z.B. Cystinol®, Uvalysat®, Arctuvan® antibiotic use in the last 7 days previous UTI in the past 2 weeks history of pyelonephritis contraindications for trial drugs serious diseases inability to understand trial Information current participation in another clinical trial or participation in another clinical trial within the last 4 weeks Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Temporal, Condition, Qualifier, Scope, Mood, Drug	[ "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "B-Condition", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "O", "B-Drug", "I-Drug", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Drug", "O", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Condition", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "B-Condition", "O", "B-Mood", "I-Mood", "B-Qualifier", "B-Drug", "O", "B-Qualifier", "B-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	signs of complicated UTI (e. g. temperature > 38°C, loin tenderness) conditions that may lead to complicated infections (i.e. renal diseases, patients with urinary catheter) pregnancy/ breastfeeding current self-medication with UU preparations e.g. z.B. Cystinol®, Uvalysat®, Arctuvan® antibiotic use in the last 7 days previous UTI in the past 2 weeks history of pyelonephritis contraindications for trial drugs serious diseases inability to understand trial Information current participation in another clinical trial or participation in another clinical trial within the last 4 weeks	[ "signs", "of", "complicated", "UTI", "(", "e.", "g.", "temperature", ">", "38", "°", "C", ",", "loin", "tenderness", ")", "\n", "conditions", "that", "may", "lead", "to", "complicated", "infections", "(", "i.e", ".", "renal", "diseases", ",", "patients", "with", "urinary", "catheter", ")", "\n", "pregnancy/", "breastfeeding", "\n", "current", "self", "-", "medication", "with", "UU", "preparations", "e.g", ".", "z.", "B.", "Cystinol", "®", ",", "Uvalysat", "®", ",", "Arctuvan", "®", "\n", "antibiotic", "use", "in", "the", "last", "7", "days", "\n", "previous", "UTI", "in", "the", "past", "2", "weeks", "\n", "history", "of", "pyelonephritis", "\n", "contraindications", "for", "trial", "drugs", "\n", "serious", "diseases", "\n", "inability", "to", "understand", "trial", "Information", "\n", "current", "participation", "in", "another", "clinical", "trial", "or", "participation", "in", "another", "clinical", "trial", "within", "the", "last", "4", "weeks", "\n" ]	[ "Scope", "Condition", "Mood", "Device", "Drug", "Qualifier", "Temporal", "Measurement", "Person", "Value" ]
complicated UTI is a Condition, temperature > 38 ° C , loin tenderness is a Scope, conditions is a Condition, complicated infections is a Condition, renal diseases , patients with urinary catheter is a Scope, self - medication is a Qualifier, UU preparations is a Drug, z. B. Cystinol ® , Uvalysat ® , Arctuvan ® is a Scope, antibiotic is a Drug, last 7 days is a Temporal, UTI is a Condition, past 2 weeks is a Temporal, pyelonephritis is a Condition, contraindications for is a Mood, trial is a Qualifier, drugs is a Drug, serious is a Qualifier, diseases is a Condition	NCT03151603_exc_task1	Sentence: signs of complicated UTI (e. g. temperature > 38°C, loin tenderness) conditions that may lead to complicated infections (i.e. renal diseases, patients with urinary catheter) pregnancy/ breastfeeding current self-medication with UU preparations e.g. z.B. Cystinol®, Uvalysat®, Arctuvan® antibiotic use in the last 7 days previous UTI in the past 2 weeks history of pyelonephritis contraindications for trial drugs serious diseases inability to understand trial Information current participation in another clinical trial or participation in another clinical trial within the last 4 weeks Instructions: please typing these entity words according to sentence: complicated UTI, temperature > 38 ° C , loin tenderness, conditions, complicated infections, renal diseases , patients with urinary catheter, self - medication, UU preparations, z. B. Cystinol ® , Uvalysat ® , Arctuvan ®, antibiotic, last 7 days, UTI, past 2 weeks, pyelonephritis, contraindications for, trial, drugs, serious, diseases Options: Temporal, Condition, Qualifier, Scope, Mood, Drug	[ "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "B-Condition", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "O", "B-Drug", "I-Drug", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Drug", "O", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Condition", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "B-Condition", "O", "B-Mood", "I-Mood", "B-Qualifier", "B-Drug", "O", "B-Qualifier", "B-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	signs of complicated UTI (e. g. temperature > 38°C, loin tenderness) conditions that may lead to complicated infections (i.e. renal diseases, patients with urinary catheter) pregnancy/ breastfeeding current self-medication with UU preparations e.g. z.B. Cystinol®, Uvalysat®, Arctuvan® antibiotic use in the last 7 days previous UTI in the past 2 weeks history of pyelonephritis contraindications for trial drugs serious diseases inability to understand trial Information current participation in another clinical trial or participation in another clinical trial within the last 4 weeks	[ "signs", "of", "complicated", "UTI", "(", "e.", "g.", "temperature", ">", "38", "°", "C", ",", "loin", "tenderness", ")", "\n", "conditions", "that", "may", "lead", "to", "complicated", "infections", "(", "i.e", ".", "renal", "diseases", ",", "patients", "with", "urinary", "catheter", ")", "\n", "pregnancy/", "breastfeeding", "\n", "current", "self", "-", "medication", "with", "UU", "preparations", "e.g", ".", "z.", "B.", "Cystinol", "®", ",", "Uvalysat", "®", ",", "Arctuvan", "®", "\n", "antibiotic", "use", "in", "the", "last", "7", "days", "\n", "previous", "UTI", "in", "the", "past", "2", "weeks", "\n", "history", "of", "pyelonephritis", "\n", "contraindications", "for", "trial", "drugs", "\n", "serious", "diseases", "\n", "inability", "to", "understand", "trial", "Information", "\n", "current", "participation", "in", "another", "clinical", "trial", "or", "participation", "in", "another", "clinical", "trial", "within", "the", "last", "4", "weeks", "\n" ]	[ "Scope", "Condition", "Mood", "Device", "Drug", "Qualifier", "Temporal", "Measurement", "Person", "Value" ]
complicated UTI, temperature > 38 ° C , loin tenderness, conditions, complicated infections, renal diseases , patients with urinary catheter, self - medication, UU preparations, z. B. Cystinol ® , Uvalysat ® , Arctuvan ®, antibiotic, last 7 days, UTI, past 2 weeks, pyelonephritis, contraindications for, trial, drugs, serious, diseases	NCT03151603_exc_task2	Sentence: signs of complicated UTI (e. g. temperature > 38°C, loin tenderness) conditions that may lead to complicated infections (i.e. renal diseases, patients with urinary catheter) pregnancy/ breastfeeding current self-medication with UU preparations e.g. z.B. Cystinol®, Uvalysat®, Arctuvan® antibiotic use in the last 7 days previous UTI in the past 2 weeks history of pyelonephritis contraindications for trial drugs serious diseases inability to understand trial Information current participation in another clinical trial or participation in another clinical trial within the last 4 weeks Instructions: please extract entity words from the input sentence	[ "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "B-Condition", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "O", "B-Drug", "I-Drug", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Drug", "O", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Condition", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "B-Condition", "O", "B-Mood", "I-Mood", "B-Qualifier", "B-Drug", "O", "B-Qualifier", "B-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	signs of complicated UTI (e. g. temperature > 38°C, loin tenderness) conditions that may lead to complicated infections (i.e. renal diseases, patients with urinary catheter) pregnancy/ breastfeeding current self-medication with UU preparations e.g. z.B. Cystinol®, Uvalysat®, Arctuvan® antibiotic use in the last 7 days previous UTI in the past 2 weeks history of pyelonephritis contraindications for trial drugs serious diseases inability to understand trial Information current participation in another clinical trial or participation in another clinical trial within the last 4 weeks	[ "signs", "of", "complicated", "UTI", "(", "e.", "g.", "temperature", ">", "38", "°", "C", ",", "loin", "tenderness", ")", "\n", "conditions", "that", "may", "lead", "to", "complicated", "infections", "(", "i.e", ".", "renal", "diseases", ",", "patients", "with", "urinary", "catheter", ")", "\n", "pregnancy/", "breastfeeding", "\n", "current", "self", "-", "medication", "with", "UU", "preparations", "e.g", ".", "z.", "B.", "Cystinol", "®", ",", "Uvalysat", "®", ",", "Arctuvan", "®", "\n", "antibiotic", "use", "in", "the", "last", "7", "days", "\n", "previous", "UTI", "in", "the", "past", "2", "weeks", "\n", "history", "of", "pyelonephritis", "\n", "contraindications", "for", "trial", "drugs", "\n", "serious", "diseases", "\n", "inability", "to", "understand", "trial", "Information", "\n", "current", "participation", "in", "another", "clinical", "trial", "or", "participation", "in", "another", "clinical", "trial", "within", "the", "last", "4", "weeks", "\n" ]	[ "Scope", "Condition", "Mood", "Device", "Drug", "Qualifier", "Temporal", "Measurement", "Person", "Value" ]
Bayesian adaptive comparative effectiveness trial is an intervention, status epilepticus is a participant	292_task0	Sentence: We present a novel Bayesian adaptive comparative effectiveness trial comparing three treatments for status epilepticus that uses adaptive randomization with potential early stopping . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: intervention, participant	[ "O", "O", "O", "O", "B-intervention", "I-intervention", "I-intervention", "I-intervention", "I-intervention", "O", "O", "O", "O", "B-participant", "I-participant", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	We present a novel Bayesian adaptive comparative effectiveness trial comparing three treatments for status epilepticus that uses adaptive randomization with potential early stopping .	[ "We", "present", "a", "novel", "Bayesian", "adaptive", "comparative", "effectiveness", "trial", "comparing", "three", "treatments", "for", "status", "epilepticus", "that", "uses", "adaptive", "randomization", "with", "potential", "early", "stopping", "." ]	[ "intervention", "participant", "outcome" ]
Bayesian adaptive comparative effectiveness trial is an intervention, status epilepticus is a participant	292_task1	Sentence: We present a novel Bayesian adaptive comparative effectiveness trial comparing three treatments for status epilepticus that uses adaptive randomization with potential early stopping . Instructions: please typing these entity words according to sentence: Bayesian adaptive comparative effectiveness trial, status epilepticus Options: intervention, participant	[ "O", "O", "O", "O", "B-intervention", "I-intervention", "I-intervention", "I-intervention", "I-intervention", "O", "O", "O", "O", "B-participant", "I-participant", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	We present a novel Bayesian adaptive comparative effectiveness trial comparing three treatments for status epilepticus that uses adaptive randomization with potential early stopping .	[ "We", "present", "a", "novel", "Bayesian", "adaptive", "comparative", "effectiveness", "trial", "comparing", "three", "treatments", "for", "status", "epilepticus", "that", "uses", "adaptive", "randomization", "with", "potential", "early", "stopping", "." ]	[ "intervention", "participant", "outcome" ]
Bayesian adaptive comparative effectiveness trial, status epilepticus	292_task2	Sentence: We present a novel Bayesian adaptive comparative effectiveness trial comparing three treatments for status epilepticus that uses adaptive randomization with potential early stopping . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-intervention", "I-intervention", "I-intervention", "I-intervention", "I-intervention", "O", "O", "O", "O", "B-participant", "I-participant", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	We present a novel Bayesian adaptive comparative effectiveness trial comparing three treatments for status epilepticus that uses adaptive randomization with potential early stopping .	[ "We", "present", "a", "novel", "Bayesian", "adaptive", "comparative", "effectiveness", "trial", "comparing", "three", "treatments", "for", "status", "epilepticus", "that", "uses", "adaptive", "randomization", "with", "potential", "early", "stopping", "." ]	[ "intervention", "participant", "outcome" ]
Patienten is an umlsterm, Tumorprophylaxe is an umlsterm, Hypertriglyzeridaemie is an umlsterm, Hautveraenderungen is an umlsterm, Restkeratosen is an umlsterm, Langzeitergebnisse is an umlsterm	DerHautarzt.80490586.ger.abstr_task0	Sentence: Wir berichten ueber einen Patienten mit kongenitaler Poikilodermie Typ Dowling , bei dem seit dem 52. Lebensjahr wiederholt M. Bowen und initiale Spinaliome in den Arealen der verruziformen Hyperkeratosen aufgetreten und exzidiert worden sind . Da eine laengerfristige Tumorprophylaxe mit Retinoiden wegen einer Hypertriglyzeridaemie Typ IV ( nach Frederickson ) nicht durchfuehrbar war , entschlossen wir uns zu einem Behandlungsversuch mittels Dermabrasio . In einem Nachbeobachtungszeitraum von 12 Monaten zeigten sich mehrere komplett abgeheilte Hautveraenderungen , daneben in einigen Arealen noch kleinere verbliebene Restkeratosen . Langzeitergebnisse stehen noch aus . Anhand des vorgestellten Falles wird das heterogene Krankheitsbild der kongenitalen Poikilodermie Typ Dowling diskutiert und auf das hohe Entartungsrisiko hingewiesen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Wir berichten ueber einen Patienten mit kongenitaler Poikilodermie Typ Dowling , bei dem seit dem 52. Lebensjahr wiederholt M. Bowen und initiale Spinaliome in den Arealen der verruziformen Hyperkeratosen aufgetreten und exzidiert worden sind . Da eine laengerfristige Tumorprophylaxe mit Retinoiden wegen einer Hypertriglyzeridaemie Typ IV ( nach Frederickson ) nicht durchfuehrbar war , entschlossen wir uns zu einem Behandlungsversuch mittels Dermabrasio . In einem Nachbeobachtungszeitraum von 12 Monaten zeigten sich mehrere komplett abgeheilte Hautveraenderungen , daneben in einigen Arealen noch kleinere verbliebene Restkeratosen . Langzeitergebnisse stehen noch aus . Anhand des vorgestellten Falles wird das heterogene Krankheitsbild der kongenitalen Poikilodermie Typ Dowling diskutiert und auf das hohe Entartungsrisiko hingewiesen .	[ "Wir", "berichten", "ueber", "einen", "Patienten", "mit", "kongenitaler", "Poikilodermie", "Typ", "Dowling", ",", "bei", "dem", "seit", "dem", "52", ".", "Lebensjahr", "wiederholt", "M.", "Bowen", "und", "initiale", "Spinaliome", "in", "den", "Arealen", "der", "verruziformen", "Hyperkeratosen", "aufgetreten", "und", "exzidiert", "worden", "sind", ".", "Da", "eine", "laengerfristige", "Tumorprophylaxe", "mit", "Retinoiden", "wegen", "einer", "Hypertriglyzeridaemie", "Typ", "IV", "(", "nach", "Frederickson", ")", "nicht", "durchfuehrbar", "war", ",", "entschlossen", "wir", "uns", "zu", "einem", "Behandlungsversuch", "mittels", "Dermabrasio", ".", "In", "einem", "Nachbeobachtungszeitraum", "von", "12", "Monaten", "zeigten", "sich", "mehrere", "komplett", "abgeheilte", "Hautveraenderungen", ",", "daneben", "in", "einigen", "Arealen", "noch", "kleinere", "verbliebene", "Restkeratosen", ".", "Langzeitergebnisse", "stehen", "noch", "aus", ".", "Anhand", "des", "vorgestellten", "Falles", "wird", "das", "heterogene", "Krankheitsbild", "der", "kongenitalen", "Poikilodermie", "Typ", "Dowling", "diskutiert", "und", "auf", "das", "hohe", "Entartungsrisiko", "hingewiesen", "." ]	[ "umlsterm" ]

male is a Person, female is a Person, recipients is a Condition, aged is a Measurement, = 60 is a Value, kidney transplantation is a Procedure, living or deceased donor , is a Scope, Expanded Criteria Donors ( ECD ) is a Qualifier, Panel Reactive Antibody ( PRA ) is a Measurement, < 30 % is a Value

NCT01631058_inc_task0

Sentence: All renal (only) male and female recipients aged = 60, years undergoing kidney transplantation from a living or deceased donor, including Expanded Criteria Donors (ECD). Panel Reactive Antibody (PRA) < 30%. Patients who consented to participate in the study by signing the informed consent form before the transplant surgery to the 1st post-operative day). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Condition, Qualifier, Value, Person, Procedure, Scope, Measurement

[ "O", "O", "O", "O", "O", "B-Person", "O", "B-Person", "B-Condition", "B-Measurement", "B-Value", "I-Value", "O", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

All renal (only) male and female recipients aged = 60, years undergoing kidney transplantation from a living or deceased donor, including Expanded Criteria Donors (ECD). Panel Reactive Antibody (PRA) < 30%. Patients who consented to participate in the study by signing the informed consent form before the transplant surgery to the 1st post-operative day).

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[ "Qualifier", "Measurement", "Scope", "Procedure", "Condition", "Person", "Value" ]

male is a Person, female is a Person, recipients is a Condition, aged is a Measurement, = 60 is a Value, kidney transplantation is a Procedure, living or deceased donor , is a Scope, Expanded Criteria Donors ( ECD ) is a Qualifier, Panel Reactive Antibody ( PRA ) is a Measurement, < 30 % is a Value

NCT01631058_inc_task1

Sentence: All renal (only) male and female recipients aged = 60, years undergoing kidney transplantation from a living or deceased donor, including Expanded Criteria Donors (ECD). Panel Reactive Antibody (PRA) < 30%. Patients who consented to participate in the study by signing the informed consent form before the transplant surgery to the 1st post-operative day). Instructions: please typing these entity words according to sentence: male, female, recipients, aged, = 60, kidney transplantation, living or deceased donor ,, Expanded Criteria Donors ( ECD ), Panel Reactive Antibody ( PRA ), < 30 % Options: Condition, Qualifier, Value, Person, Procedure, Scope, Measurement

[ "O", "O", "O", "O", "O", "B-Person", "O", "B-Person", "B-Condition", "B-Measurement", "B-Value", "I-Value", "O", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

All renal (only) male and female recipients aged = 60, years undergoing kidney transplantation from a living or deceased donor, including Expanded Criteria Donors (ECD). Panel Reactive Antibody (PRA) < 30%. Patients who consented to participate in the study by signing the informed consent form before the transplant surgery to the 1st post-operative day).

[ "All", "renal", "(", "only", ")", "male", "and", "female", "recipients", "aged", "=", "60", ",", "years", "undergoing", "kidney", "transplantation", "from", "a", "living", "or", "deceased", "donor", ",", "including", "Expanded", "Criteria", "Donors", "(", "ECD", ")", ".", "\n", "Panel", "Reactive", "Antibody", "(", "PRA", ")", "<", "30", "%", ".", "\n", "Patients", "who", "consented", "to", "participate", "in", "the", "study", "by", "signing", "the", "informed", "consent", "form", "before", "the", "transplant", "surgery", "to", "the", "1st", "post", "-", "operative", "day", ")", ".", "\n" ]

[ "Qualifier", "Measurement", "Scope", "Procedure", "Condition", "Person", "Value" ]

male, female, recipients, aged, = 60, kidney transplantation, living or deceased donor ,, Expanded Criteria Donors ( ECD ), Panel Reactive Antibody ( PRA ), < 30 %

NCT01631058_inc_task2

Sentence: All renal (only) male and female recipients aged = 60, years undergoing kidney transplantation from a living or deceased donor, including Expanded Criteria Donors (ECD). Panel Reactive Antibody (PRA) < 30%. Patients who consented to participate in the study by signing the informed consent form before the transplant surgery to the 1st post-operative day). Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "B-Person", "O", "B-Person", "B-Condition", "B-Measurement", "B-Value", "I-Value", "O", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

All renal (only) male and female recipients aged = 60, years undergoing kidney transplantation from a living or deceased donor, including Expanded Criteria Donors (ECD). Panel Reactive Antibody (PRA) < 30%. Patients who consented to participate in the study by signing the informed consent form before the transplant surgery to the 1st post-operative day).

[ "All", "renal", "(", "only", ")", "male", "and", "female", "recipients", "aged", "=", "60", ",", "years", "undergoing", "kidney", "transplantation", "from", "a", "living", "or", "deceased", "donor", ",", "including", "Expanded", "Criteria", "Donors", "(", "ECD", ")", ".", "\n", "Panel", "Reactive", "Antibody", "(", "PRA", ")", "<", "30", "%", ".", "\n", "Patients", "who", "consented", "to", "participate", "in", "the", "study", "by", "signing", "the", "informed", "consent", "form", "before", "the", "transplant", "surgery", "to", "the", "1st", "post", "-", "operative", "day", ")", ".", "\n" ]

[ "Qualifier", "Measurement", "Scope", "Procedure", "Condition", "Person", "Value" ]

ZMPSTE24 is a Gene, LMNA is a Gene, LMNA is a Gene, ZMPSTE24 is a Gene, ZMPSTE24 is a Gene, LMNA is a Gene, ZMPSTE24 is a Gene, LMNA is a Gene

564_task0

Sentence: A homozygous ZMPSTE24 null mutation in combination with a heterozygous mutation in the LMNA gene causes Hutchinson-Gilford progeria syndrome (HGPS): insights into the pathophysiology of HGPS. Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder normally caused by a spontaneous heterozygous mutation in the LMNA gene that codes for the nuclear lamina protein lamin A. Several enzymes are involved in the processing of its precursor, prelamin A, to the mature lamin A. A functional knockout of one of the enzymes involved in prelamin A processing, the zinc metalloprotease ZMPSTE24, causes an even more severe disorder with early neonatal death described as restrictive dermatopathy (RD). This work describes a HGPS patient with a combined defect of a homozygous loss-of-function mutation in the ZMPSTE24 gene and a heterozygous mutation in the LMNA gene that results in a C-terminal elongation of the final lamin A. Whereas the loss of function mutation of ZMPSTE24 normally results in lethal RD, the truncation of LMNA seems to be a salvage alteration alleviating the clinical picture to the HGPS phenotype. The mutations of our patient indicate that farnesylated prelamin A is the deleterious agent leading to the HGPS phenotype, which gives further insights into the pathophysiology of the disorder. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Gene

[ "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

A homozygous ZMPSTE24 null mutation in combination with a heterozygous mutation in the LMNA gene causes Hutchinson-Gilford progeria syndrome (HGPS): insights into the pathophysiology of HGPS. Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder normally caused by a spontaneous heterozygous mutation in the LMNA gene that codes for the nuclear lamina protein lamin A. Several enzymes are involved in the processing of its precursor, prelamin A, to the mature lamin A. A functional knockout of one of the enzymes involved in prelamin A processing, the zinc metalloprotease ZMPSTE24, causes an even more severe disorder with early neonatal death described as restrictive dermatopathy (RD). This work describes a HGPS patient with a combined defect of a homozygous loss-of-function mutation in the ZMPSTE24 gene and a heterozygous mutation in the LMNA gene that results in a C-terminal elongation of the final lamin A. Whereas the loss of function mutation of ZMPSTE24 normally results in lethal RD, the truncation of LMNA seems to be a salvage alteration alleviating the clinical picture to the HGPS phenotype. The mutations of our patient indicate that farnesylated prelamin A is the deleterious agent leading to the HGPS phenotype, which gives further insights into the pathophysiology of the disorder.

[ "A", "homozygous", "ZMPSTE24", "null", "mutation", "in", "combination", "with", "a", "heterozygous", "mutation", "in", "the", "LMNA", "gene", "causes", "Hutchinson", "-", "Gilford", "progeria", "syndrome", "(", "HGPS", "):", "insights", "into", "the", "pathophysiology", "of", "HGPS", ".", "Hutchinson", "-", "Gilford", "progeria", "syndrome", "(", "HGPS", ")", "is", "a", "rare", "premature", "aging", "disorder", "normally", "caused", "by", "a", "spontaneous", "heterozygous", "mutation", "in", "the", "LMNA", "gene", "that", "codes", "for", "the", "nuclear", "lamina", "protein", "lamin", "A.", "Several", "enzymes", "are", "involved", "in", "the", "processing", "of", "its", "precursor", ",", "prelamin", "A", ",", "to", "the", "mature", "lamin", "A.", "A", "functional", "knockout", "of", "one", "of", "the", "enzymes", "involved", "in", "prelamin", "A", "processing", ",", "the", "zinc", "metalloprotease", "ZMPSTE24", ",", "causes", "an", "even", "more", "severe", "disorder", "with", "early", "neonatal", "death", "described", "as", "restrictive", "dermatopathy", "(", "RD", ")", ".", "This", "work", "describes", "a", "HGPS", "patient", "with", "a", "combined", "defect", "of", "a", "homozygous", "loss", "-", "of", "-", "function", "mutation", "in", "the", "ZMPSTE24", "gene", "and", "a", "heterozygous", "mutation", "in", "the", "LMNA", "gene", "that", "results", "in", "a", "C", "-", "terminal", "elongation", "of", "the", "final", "lamin", "A.", "Whereas", "the", "loss", "of", "function", "mutation", "of", "ZMPSTE24", "normally", "results", "in", "lethal", "RD", ",", "the", "truncation", "of", "LMNA", "seems", "to", "be", "a", "salvage", "alteration", "alleviating", "the", "clinical", "picture", "to", "the", "HGPS", "phenotype", ".", "The", "mutations", "of", "our", "patient", "indicate", "that", "farnesylated", "prelamin", "A", "is", "the", "deleterious", "agent", "leading", "to", "the", "HGPS", "phenotype", ",", "which", "gives", "further", "insights", "into", "the", "pathophysiology", "of", "the", "disorder", ".", "\n" ]

[ "Gene" ]

ZMPSTE24 is a Gene, LMNA is a Gene, LMNA is a Gene, ZMPSTE24 is a Gene, ZMPSTE24 is a Gene, LMNA is a Gene, ZMPSTE24 is a Gene, LMNA is a Gene

564_task1

Sentence: A homozygous ZMPSTE24 null mutation in combination with a heterozygous mutation in the LMNA gene causes Hutchinson-Gilford progeria syndrome (HGPS): insights into the pathophysiology of HGPS. Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder normally caused by a spontaneous heterozygous mutation in the LMNA gene that codes for the nuclear lamina protein lamin A. Several enzymes are involved in the processing of its precursor, prelamin A, to the mature lamin A. A functional knockout of one of the enzymes involved in prelamin A processing, the zinc metalloprotease ZMPSTE24, causes an even more severe disorder with early neonatal death described as restrictive dermatopathy (RD). This work describes a HGPS patient with a combined defect of a homozygous loss-of-function mutation in the ZMPSTE24 gene and a heterozygous mutation in the LMNA gene that results in a C-terminal elongation of the final lamin A. Whereas the loss of function mutation of ZMPSTE24 normally results in lethal RD, the truncation of LMNA seems to be a salvage alteration alleviating the clinical picture to the HGPS phenotype. The mutations of our patient indicate that farnesylated prelamin A is the deleterious agent leading to the HGPS phenotype, which gives further insights into the pathophysiology of the disorder. Instructions: please typing these entity words according to sentence: ZMPSTE24, LMNA, LMNA, ZMPSTE24, ZMPSTE24, LMNA, ZMPSTE24, LMNA Options: Gene

[ "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

A homozygous ZMPSTE24 null mutation in combination with a heterozygous mutation in the LMNA gene causes Hutchinson-Gilford progeria syndrome (HGPS): insights into the pathophysiology of HGPS. Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder normally caused by a spontaneous heterozygous mutation in the LMNA gene that codes for the nuclear lamina protein lamin A. Several enzymes are involved in the processing of its precursor, prelamin A, to the mature lamin A. A functional knockout of one of the enzymes involved in prelamin A processing, the zinc metalloprotease ZMPSTE24, causes an even more severe disorder with early neonatal death described as restrictive dermatopathy (RD). This work describes a HGPS patient with a combined defect of a homozygous loss-of-function mutation in the ZMPSTE24 gene and a heterozygous mutation in the LMNA gene that results in a C-terminal elongation of the final lamin A. Whereas the loss of function mutation of ZMPSTE24 normally results in lethal RD, the truncation of LMNA seems to be a salvage alteration alleviating the clinical picture to the HGPS phenotype. The mutations of our patient indicate that farnesylated prelamin A is the deleterious agent leading to the HGPS phenotype, which gives further insights into the pathophysiology of the disorder.

[ "A", "homozygous", "ZMPSTE24", "null", "mutation", "in", "combination", "with", "a", "heterozygous", "mutation", "in", "the", "LMNA", "gene", "causes", "Hutchinson", "-", "Gilford", "progeria", "syndrome", "(", "HGPS", "):", "insights", "into", "the", "pathophysiology", "of", "HGPS", ".", "Hutchinson", "-", "Gilford", "progeria", "syndrome", "(", "HGPS", ")", "is", "a", "rare", "premature", "aging", "disorder", "normally", "caused", "by", "a", "spontaneous", "heterozygous", "mutation", "in", "the", "LMNA", "gene", "that", "codes", "for", "the", "nuclear", "lamina", "protein", "lamin", "A.", "Several", "enzymes", "are", "involved", "in", "the", "processing", "of", "its", "precursor", ",", "prelamin", "A", ",", "to", "the", "mature", "lamin", "A.", "A", "functional", "knockout", "of", "one", "of", "the", "enzymes", "involved", "in", "prelamin", "A", "processing", ",", "the", "zinc", "metalloprotease", "ZMPSTE24", ",", "causes", "an", "even", "more", "severe", "disorder", "with", "early", "neonatal", "death", "described", "as", "restrictive", "dermatopathy", "(", "RD", ")", ".", "This", "work", "describes", "a", "HGPS", "patient", "with", "a", "combined", "defect", "of", "a", "homozygous", "loss", "-", "of", "-", "function", "mutation", "in", "the", "ZMPSTE24", "gene", "and", "a", "heterozygous", "mutation", "in", "the", "LMNA", "gene", "that", "results", "in", "a", "C", "-", "terminal", "elongation", "of", "the", "final", "lamin", "A.", "Whereas", "the", "loss", "of", "function", "mutation", "of", "ZMPSTE24", "normally", "results", "in", "lethal", "RD", ",", "the", "truncation", "of", "LMNA", "seems", "to", "be", "a", "salvage", "alteration", "alleviating", "the", "clinical", "picture", "to", "the", "HGPS", "phenotype", ".", "The", "mutations", "of", "our", "patient", "indicate", "that", "farnesylated", "prelamin", "A", "is", "the", "deleterious", "agent", "leading", "to", "the", "HGPS", "phenotype", ",", "which", "gives", "further", "insights", "into", "the", "pathophysiology", "of", "the", "disorder", ".", "\n" ]

[ "Gene" ]

ZMPSTE24, LMNA, LMNA, ZMPSTE24, ZMPSTE24, LMNA, ZMPSTE24, LMNA

564_task2

Sentence: A homozygous ZMPSTE24 null mutation in combination with a heterozygous mutation in the LMNA gene causes Hutchinson-Gilford progeria syndrome (HGPS): insights into the pathophysiology of HGPS. Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder normally caused by a spontaneous heterozygous mutation in the LMNA gene that codes for the nuclear lamina protein lamin A. Several enzymes are involved in the processing of its precursor, prelamin A, to the mature lamin A. A functional knockout of one of the enzymes involved in prelamin A processing, the zinc metalloprotease ZMPSTE24, causes an even more severe disorder with early neonatal death described as restrictive dermatopathy (RD). This work describes a HGPS patient with a combined defect of a homozygous loss-of-function mutation in the ZMPSTE24 gene and a heterozygous mutation in the LMNA gene that results in a C-terminal elongation of the final lamin A. Whereas the loss of function mutation of ZMPSTE24 normally results in lethal RD, the truncation of LMNA seems to be a salvage alteration alleviating the clinical picture to the HGPS phenotype. The mutations of our patient indicate that farnesylated prelamin A is the deleterious agent leading to the HGPS phenotype, which gives further insights into the pathophysiology of the disorder. Instructions: please extract entity words from the input sentence

[ "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

A homozygous ZMPSTE24 null mutation in combination with a heterozygous mutation in the LMNA gene causes Hutchinson-Gilford progeria syndrome (HGPS): insights into the pathophysiology of HGPS. Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder normally caused by a spontaneous heterozygous mutation in the LMNA gene that codes for the nuclear lamina protein lamin A. Several enzymes are involved in the processing of its precursor, prelamin A, to the mature lamin A. A functional knockout of one of the enzymes involved in prelamin A processing, the zinc metalloprotease ZMPSTE24, causes an even more severe disorder with early neonatal death described as restrictive dermatopathy (RD). This work describes a HGPS patient with a combined defect of a homozygous loss-of-function mutation in the ZMPSTE24 gene and a heterozygous mutation in the LMNA gene that results in a C-terminal elongation of the final lamin A. Whereas the loss of function mutation of ZMPSTE24 normally results in lethal RD, the truncation of LMNA seems to be a salvage alteration alleviating the clinical picture to the HGPS phenotype. The mutations of our patient indicate that farnesylated prelamin A is the deleterious agent leading to the HGPS phenotype, which gives further insights into the pathophysiology of the disorder.

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[ "Gene" ]

COL1A2 is a gene

22_task0

Sentence: Collagen type I alpha2 ( COL1A2 ) is the susceptible gene for intracranial aneurysms. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: gene

[ "O", "O", "O", "O", "O", "O", "B-gene", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Collagen type I alpha2 ( COL1A2 ) is the susceptible gene for intracranial aneurysms.

[ "Collagen", "type", "I", "alpha2", " ", "(", "COL1A2", ")", "is", "the", "susceptible", "gene", "for", "intracranial", "aneurysms", "." ]

[ "variant", "gene" ]

COL1A2 is a gene

22_task1

Sentence: Collagen type I alpha2 ( COL1A2 ) is the susceptible gene for intracranial aneurysms. Instructions: please typing these entity words according to sentence: COL1A2 Options: gene

[ "O", "O", "O", "O", "O", "O", "B-gene", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Collagen type I alpha2 ( COL1A2 ) is the susceptible gene for intracranial aneurysms.

[ "Collagen", "type", "I", "alpha2", " ", "(", "COL1A2", ")", "is", "the", "susceptible", "gene", "for", "intracranial", "aneurysms", "." ]

[ "variant", "gene" ]

COL1A2

22_task2

Sentence: Collagen type I alpha2 ( COL1A2 ) is the susceptible gene for intracranial aneurysms. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "B-gene", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Collagen type I alpha2 ( COL1A2 ) is the susceptible gene for intracranial aneurysms.

[ "Collagen", "type", "I", "alpha2", " ", "(", "COL1A2", ")", "is", "the", "susceptible", "gene", "for", "intracranial", "aneurysms", "." ]

[ "variant", "gene" ]

imidafenacin versus fesoterodine is a Intervention_Pharmacological, overactive bladder . is a Participant_Condition, efficacy and safety is a Outcome_Other, patients with overactive bladder ( OAB ) . is a Participant_Age, fesoterodine - controlled is a Intervention_Control, clinical laboratory tests is a Outcome_Other

62458_task0

Sentence: A randomised , double-blind , parallel design , multi-institutional , non-inferiority phase IV trial of imidafenacin versus fesoterodine for overactive bladder . AIMS Our objective was to compare the efficacy and safety of imidafenacin over fesoterodine in patients with overactive bladder ( OAB ) . METHODS This study is a randomised , double-blind , parallel-group , fesoterodine-controlled study in patients with continuous OAB symptoms for ≥ 3 months , daily mean voiding frequency ( DMVF ) ≥ 8 , and daily mean urgency or urgency incontinence frequency ≥ 2 . A twice-daily 0.1 mg imidafenacin with placebo , or once-daily 4 mg fesoterodine with placebo were administered for 12 weeks . The primary efficacy end-point was the difference in DMVF at 12 weeks . The secondary efficacy end-points were differences in daily mean : ( i ) voiding frequency at 4 and 8 weeks ; ( ii ) urgency frequency ; ( iii ) urgency incontinence frequency ; ( iv ) incontinence frequency ; ( v ) nocturia frequency ; and ( vi ) quality of life score . The variables for safety analysis were adverse events , vital signs , residual urine volume and clinical laboratory tests . An efficacy analysis was conducted in per-protocol patients and the safety analysis was conducted in all randomised patients . RESULTS The differences in DMVF at 12 weeks were -3.38 ± 3.63 and -2.45 ± 3.73 in the imidafenacin and fesoterodine groups , respectively , and the difference was not significant between the two groups . Imidafenacin was non-inferior to fesoterodine , and the lower limit of 95 % two-sided confidence intervals was -0.53 . The other six secondary end-points and variables for safety analysis showed no difference between the two groups . CONCLUSIONS Imidafenacin was non-inferior to fesoterodine in terms of efficacy , and showed no significant difference in terms of safety . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Intervention_Control, Participant_Condition, Participant_Age, Outcome_Other

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A randomised , double-blind , parallel design , multi-institutional , non-inferiority phase IV trial of imidafenacin versus fesoterodine for overactive bladder . AIMS Our objective was to compare the efficacy and safety of imidafenacin over fesoterodine in patients with overactive bladder ( OAB ) . METHODS This study is a randomised , double-blind , parallel-group , fesoterodine-controlled study in patients with continuous OAB symptoms for ≥ 3 months , daily mean voiding frequency ( DMVF ) ≥ 8 , and daily mean urgency or urgency incontinence frequency ≥ 2 . A twice-daily 0.1 mg imidafenacin with placebo , or once-daily 4 mg fesoterodine with placebo were administered for 12 weeks . The primary efficacy end-point was the difference in DMVF at 12 weeks . The secondary efficacy end-points were differences in daily mean : ( i ) voiding frequency at 4 and 8 weeks ; ( ii ) urgency frequency ; ( iii ) urgency incontinence frequency ; ( iv ) incontinence frequency ; ( v ) nocturia frequency ; and ( vi ) quality of life score . The variables for safety analysis were adverse events , vital signs , residual urine volume and clinical laboratory tests . An efficacy analysis was conducted in per-protocol patients and the safety analysis was conducted in all randomised patients . RESULTS The differences in DMVF at 12 weeks were -3.38 ± 3.63 and -2.45 ± 3.73 in the imidafenacin and fesoterodine groups , respectively , and the difference was not significant between the two groups . Imidafenacin was non-inferior to fesoterodine , and the lower limit of 95 % two-sided confidence intervals was -0.53 . The other six secondary end-points and variables for safety analysis showed no difference between the two groups . CONCLUSIONS Imidafenacin was non-inferior to fesoterodine in terms of efficacy , and showed no significant difference in terms of safety .

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[ "Participant_Age", "Intervention_Pharmacological", "Outcome_Other", "Intervention_Control", "Participant_Condition" ]

imidafenacin versus fesoterodine is a Intervention_Pharmacological, overactive bladder . is a Participant_Condition, efficacy and safety is a Outcome_Other, patients with overactive bladder ( OAB ) . is a Participant_Age, fesoterodine - controlled is a Intervention_Control, clinical laboratory tests is a Outcome_Other

62458_task1

Sentence: A randomised , double-blind , parallel design , multi-institutional , non-inferiority phase IV trial of imidafenacin versus fesoterodine for overactive bladder . AIMS Our objective was to compare the efficacy and safety of imidafenacin over fesoterodine in patients with overactive bladder ( OAB ) . METHODS This study is a randomised , double-blind , parallel-group , fesoterodine-controlled study in patients with continuous OAB symptoms for ≥ 3 months , daily mean voiding frequency ( DMVF ) ≥ 8 , and daily mean urgency or urgency incontinence frequency ≥ 2 . A twice-daily 0.1 mg imidafenacin with placebo , or once-daily 4 mg fesoterodine with placebo were administered for 12 weeks . The primary efficacy end-point was the difference in DMVF at 12 weeks . The secondary efficacy end-points were differences in daily mean : ( i ) voiding frequency at 4 and 8 weeks ; ( ii ) urgency frequency ; ( iii ) urgency incontinence frequency ; ( iv ) incontinence frequency ; ( v ) nocturia frequency ; and ( vi ) quality of life score . The variables for safety analysis were adverse events , vital signs , residual urine volume and clinical laboratory tests . An efficacy analysis was conducted in per-protocol patients and the safety analysis was conducted in all randomised patients . RESULTS The differences in DMVF at 12 weeks were -3.38 ± 3.63 and -2.45 ± 3.73 in the imidafenacin and fesoterodine groups , respectively , and the difference was not significant between the two groups . Imidafenacin was non-inferior to fesoterodine , and the lower limit of 95 % two-sided confidence intervals was -0.53 . The other six secondary end-points and variables for safety analysis showed no difference between the two groups . CONCLUSIONS Imidafenacin was non-inferior to fesoterodine in terms of efficacy , and showed no significant difference in terms of safety . Instructions: please typing these entity words according to sentence: imidafenacin versus fesoterodine, overactive bladder ., efficacy and safety, patients with overactive bladder ( OAB ) ., fesoterodine - controlled, clinical laboratory tests Options: Intervention_Pharmacological, Intervention_Control, Participant_Condition, Participant_Age, Outcome_Other

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A randomised , double-blind , parallel design , multi-institutional , non-inferiority phase IV trial of imidafenacin versus fesoterodine for overactive bladder . AIMS Our objective was to compare the efficacy and safety of imidafenacin over fesoterodine in patients with overactive bladder ( OAB ) . METHODS This study is a randomised , double-blind , parallel-group , fesoterodine-controlled study in patients with continuous OAB symptoms for ≥ 3 months , daily mean voiding frequency ( DMVF ) ≥ 8 , and daily mean urgency or urgency incontinence frequency ≥ 2 . A twice-daily 0.1 mg imidafenacin with placebo , or once-daily 4 mg fesoterodine with placebo were administered for 12 weeks . The primary efficacy end-point was the difference in DMVF at 12 weeks . The secondary efficacy end-points were differences in daily mean : ( i ) voiding frequency at 4 and 8 weeks ; ( ii ) urgency frequency ; ( iii ) urgency incontinence frequency ; ( iv ) incontinence frequency ; ( v ) nocturia frequency ; and ( vi ) quality of life score . The variables for safety analysis were adverse events , vital signs , residual urine volume and clinical laboratory tests . An efficacy analysis was conducted in per-protocol patients and the safety analysis was conducted in all randomised patients . RESULTS The differences in DMVF at 12 weeks were -3.38 ± 3.63 and -2.45 ± 3.73 in the imidafenacin and fesoterodine groups , respectively , and the difference was not significant between the two groups . Imidafenacin was non-inferior to fesoterodine , and the lower limit of 95 % two-sided confidence intervals was -0.53 . The other six secondary end-points and variables for safety analysis showed no difference between the two groups . CONCLUSIONS Imidafenacin was non-inferior to fesoterodine in terms of efficacy , and showed no significant difference in terms of safety .

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[ "Participant_Age", "Intervention_Pharmacological", "Outcome_Other", "Intervention_Control", "Participant_Condition" ]

imidafenacin versus fesoterodine, overactive bladder ., efficacy and safety, patients with overactive bladder ( OAB ) ., fesoterodine - controlled, clinical laboratory tests

62458_task2

Sentence: A randomised , double-blind , parallel design , multi-institutional , non-inferiority phase IV trial of imidafenacin versus fesoterodine for overactive bladder . AIMS Our objective was to compare the efficacy and safety of imidafenacin over fesoterodine in patients with overactive bladder ( OAB ) . METHODS This study is a randomised , double-blind , parallel-group , fesoterodine-controlled study in patients with continuous OAB symptoms for ≥ 3 months , daily mean voiding frequency ( DMVF ) ≥ 8 , and daily mean urgency or urgency incontinence frequency ≥ 2 . A twice-daily 0.1 mg imidafenacin with placebo , or once-daily 4 mg fesoterodine with placebo were administered for 12 weeks . The primary efficacy end-point was the difference in DMVF at 12 weeks . The secondary efficacy end-points were differences in daily mean : ( i ) voiding frequency at 4 and 8 weeks ; ( ii ) urgency frequency ; ( iii ) urgency incontinence frequency ; ( iv ) incontinence frequency ; ( v ) nocturia frequency ; and ( vi ) quality of life score . The variables for safety analysis were adverse events , vital signs , residual urine volume and clinical laboratory tests . An efficacy analysis was conducted in per-protocol patients and the safety analysis was conducted in all randomised patients . RESULTS The differences in DMVF at 12 weeks were -3.38 ± 3.63 and -2.45 ± 3.73 in the imidafenacin and fesoterodine groups , respectively , and the difference was not significant between the two groups . Imidafenacin was non-inferior to fesoterodine , and the lower limit of 95 % two-sided confidence intervals was -0.53 . The other six secondary end-points and variables for safety analysis showed no difference between the two groups . CONCLUSIONS Imidafenacin was non-inferior to fesoterodine in terms of efficacy , and showed no significant difference in terms of safety . Instructions: please extract entity words from the input sentence

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A randomised , double-blind , parallel design , multi-institutional , non-inferiority phase IV trial of imidafenacin versus fesoterodine for overactive bladder . AIMS Our objective was to compare the efficacy and safety of imidafenacin over fesoterodine in patients with overactive bladder ( OAB ) . METHODS This study is a randomised , double-blind , parallel-group , fesoterodine-controlled study in patients with continuous OAB symptoms for ≥ 3 months , daily mean voiding frequency ( DMVF ) ≥ 8 , and daily mean urgency or urgency incontinence frequency ≥ 2 . A twice-daily 0.1 mg imidafenacin with placebo , or once-daily 4 mg fesoterodine with placebo were administered for 12 weeks . The primary efficacy end-point was the difference in DMVF at 12 weeks . The secondary efficacy end-points were differences in daily mean : ( i ) voiding frequency at 4 and 8 weeks ; ( ii ) urgency frequency ; ( iii ) urgency incontinence frequency ; ( iv ) incontinence frequency ; ( v ) nocturia frequency ; and ( vi ) quality of life score . The variables for safety analysis were adverse events , vital signs , residual urine volume and clinical laboratory tests . An efficacy analysis was conducted in per-protocol patients and the safety analysis was conducted in all randomised patients . RESULTS The differences in DMVF at 12 weeks were -3.38 ± 3.63 and -2.45 ± 3.73 in the imidafenacin and fesoterodine groups , respectively , and the difference was not significant between the two groups . Imidafenacin was non-inferior to fesoterodine , and the lower limit of 95 % two-sided confidence intervals was -0.53 . The other six secondary end-points and variables for safety analysis showed no difference between the two groups . CONCLUSIONS Imidafenacin was non-inferior to fesoterodine in terms of efficacy , and showed no significant difference in terms of safety .

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[ "Participant_Age", "Intervention_Pharmacological", "Outcome_Other", "Intervention_Control", "Participant_Condition" ]

memantine is a CHEMICAL

14530799_task0

Sentence: The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL

[ "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O" ]

The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease.

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[ "GENE-N", "GENE-Y", "CHEMICAL" ]

memantine is a CHEMICAL

14530799_task1

Sentence: The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease. Instructions: please typing these entity words according to sentence: memantine Options: CHEMICAL

[ "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O" ]

The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease.

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[ "GENE-N", "GENE-Y", "CHEMICAL" ]

memantine

14530799_task2

Sentence: The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O" ]

The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease.

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[ "GENE-N", "GENE-Y", "CHEMICAL" ]

Papillomviren is an umlsterm, Karzinomen is an umlsterm, Impfstoffes is an umlsterm, krebsassoziierte is an umlsterm, therapeutischen Anwendung is an umlsterm, Vakzine is an umlsterm, Infektion is an umlsterm, Antikoerper is an umlsterm, Tiermodell is an umlsterm, Papillomviren is an umlsterm, Wirtszelle is an umlsterm, Antikoerper is an umlsterm, virusaehnliche is an umlsterm, Strukturproteinen is an umlsterm, Impfstoff is an umlsterm, Fruehproteine is an umlsterm, Papillomviren is an umlsterm, Epidermis is an umlsterm, Antigen is an umlsterm, T - Zellen is an umlsterm, Peptiden is an umlsterm, Impfstoff is an umlsterm

DerHautarzt.60470739.ger.abstr_task0

Sentence: Humane Papillomviren ( HPV ) sind Ursache haeufiger epithelialer Proliferationen und an der Entstehung von anogenitalen Karzinomen wesentlich beteiligt . Bei der Entwicklung eines Impfstoffes gegen krebsassoziierte HPV wird infolge zweier grundsaetzlicher Ziele sowohl in Richtung der Prophylaxe als auch einer therapeutischen Anwendung gearbeitet . Eine Vakzine zur Verhinderung einer Infektion mit HPV scheint in naher Zukunft herstellbar . Antikoerper gegen dreidimensionale Kapsidstrukturen schuetzen im Tiermodell vor dem Eindringen der Papillomviren in die Wirtszelle , und diese wichtigen neutralisierenden Antikoerper koennen durch DNA-freie virusaehnliche Kapsidpartikel aus spontan rearrangierten Strukturproteinen induziert werden . Solche Partikel gelten deshalb als sicherer , prophylaktisch wirksamer Impfstoff . Eine ideale HPV-Vakzine sollte zusaetzlich die durch zellulaere Immunmechanismen vermittelte Rueckbildung von bereits bestehenden praekanzeroesen und auch von malignen Laesionen vermitteln . Die transformierenden Fruehproteine der Papillomviren , die in Basalzellen der Epidermis als ein hypothetisches Antigen spezifischer T-Zellen exprimiert sind , koennten in Form von synthetischen Peptiden fuer einen solchen Impfstoff eingesetzt werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Humane Papillomviren ( HPV ) sind Ursache haeufiger epithelialer Proliferationen und an der Entstehung von anogenitalen Karzinomen wesentlich beteiligt . Bei der Entwicklung eines Impfstoffes gegen krebsassoziierte HPV wird infolge zweier grundsaetzlicher Ziele sowohl in Richtung der Prophylaxe als auch einer therapeutischen Anwendung gearbeitet . Eine Vakzine zur Verhinderung einer Infektion mit HPV scheint in naher Zukunft herstellbar . Antikoerper gegen dreidimensionale Kapsidstrukturen schuetzen im Tiermodell vor dem Eindringen der Papillomviren in die Wirtszelle , und diese wichtigen neutralisierenden Antikoerper koennen durch DNA-freie virusaehnliche Kapsidpartikel aus spontan rearrangierten Strukturproteinen induziert werden . Solche Partikel gelten deshalb als sicherer , prophylaktisch wirksamer Impfstoff . Eine ideale HPV-Vakzine sollte zusaetzlich die durch zellulaere Immunmechanismen vermittelte Rueckbildung von bereits bestehenden praekanzeroesen und auch von malignen Laesionen vermitteln . Die transformierenden Fruehproteine der Papillomviren , die in Basalzellen der Epidermis als ein hypothetisches Antigen spezifischer T-Zellen exprimiert sind , koennten in Form von synthetischen Peptiden fuer einen solchen Impfstoff eingesetzt werden .

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[ "umlsterm" ]

Papillomviren is an umlsterm, Karzinomen is an umlsterm, Impfstoffes is an umlsterm, krebsassoziierte is an umlsterm, therapeutischen Anwendung is an umlsterm, Vakzine is an umlsterm, Infektion is an umlsterm, Antikoerper is an umlsterm, Tiermodell is an umlsterm, Papillomviren is an umlsterm, Wirtszelle is an umlsterm, Antikoerper is an umlsterm, virusaehnliche is an umlsterm, Strukturproteinen is an umlsterm, Impfstoff is an umlsterm, Fruehproteine is an umlsterm, Papillomviren is an umlsterm, Epidermis is an umlsterm, Antigen is an umlsterm, T - Zellen is an umlsterm, Peptiden is an umlsterm, Impfstoff is an umlsterm

DerHautarzt.60470739.ger.abstr_task1

Sentence: Humane Papillomviren ( HPV ) sind Ursache haeufiger epithelialer Proliferationen und an der Entstehung von anogenitalen Karzinomen wesentlich beteiligt . Bei der Entwicklung eines Impfstoffes gegen krebsassoziierte HPV wird infolge zweier grundsaetzlicher Ziele sowohl in Richtung der Prophylaxe als auch einer therapeutischen Anwendung gearbeitet . Eine Vakzine zur Verhinderung einer Infektion mit HPV scheint in naher Zukunft herstellbar . Antikoerper gegen dreidimensionale Kapsidstrukturen schuetzen im Tiermodell vor dem Eindringen der Papillomviren in die Wirtszelle , und diese wichtigen neutralisierenden Antikoerper koennen durch DNA-freie virusaehnliche Kapsidpartikel aus spontan rearrangierten Strukturproteinen induziert werden . Solche Partikel gelten deshalb als sicherer , prophylaktisch wirksamer Impfstoff . Eine ideale HPV-Vakzine sollte zusaetzlich die durch zellulaere Immunmechanismen vermittelte Rueckbildung von bereits bestehenden praekanzeroesen und auch von malignen Laesionen vermitteln . Die transformierenden Fruehproteine der Papillomviren , die in Basalzellen der Epidermis als ein hypothetisches Antigen spezifischer T-Zellen exprimiert sind , koennten in Form von synthetischen Peptiden fuer einen solchen Impfstoff eingesetzt werden . Instructions: please typing these entity words according to sentence: Papillomviren, Karzinomen, Impfstoffes, krebsassoziierte, therapeutischen Anwendung, Vakzine, Infektion, Antikoerper, Tiermodell, Papillomviren, Wirtszelle, Antikoerper, virusaehnliche, Strukturproteinen, Impfstoff, Fruehproteine, Papillomviren, Epidermis, Antigen, T - Zellen, Peptiden, Impfstoff Options: umlsterm

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Humane Papillomviren ( HPV ) sind Ursache haeufiger epithelialer Proliferationen und an der Entstehung von anogenitalen Karzinomen wesentlich beteiligt . Bei der Entwicklung eines Impfstoffes gegen krebsassoziierte HPV wird infolge zweier grundsaetzlicher Ziele sowohl in Richtung der Prophylaxe als auch einer therapeutischen Anwendung gearbeitet . Eine Vakzine zur Verhinderung einer Infektion mit HPV scheint in naher Zukunft herstellbar . Antikoerper gegen dreidimensionale Kapsidstrukturen schuetzen im Tiermodell vor dem Eindringen der Papillomviren in die Wirtszelle , und diese wichtigen neutralisierenden Antikoerper koennen durch DNA-freie virusaehnliche Kapsidpartikel aus spontan rearrangierten Strukturproteinen induziert werden . Solche Partikel gelten deshalb als sicherer , prophylaktisch wirksamer Impfstoff . Eine ideale HPV-Vakzine sollte zusaetzlich die durch zellulaere Immunmechanismen vermittelte Rueckbildung von bereits bestehenden praekanzeroesen und auch von malignen Laesionen vermitteln . Die transformierenden Fruehproteine der Papillomviren , die in Basalzellen der Epidermis als ein hypothetisches Antigen spezifischer T-Zellen exprimiert sind , koennten in Form von synthetischen Peptiden fuer einen solchen Impfstoff eingesetzt werden .

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[ "umlsterm" ]

Papillomviren, Karzinomen, Impfstoffes, krebsassoziierte, therapeutischen Anwendung, Vakzine, Infektion, Antikoerper, Tiermodell, Papillomviren, Wirtszelle, Antikoerper, virusaehnliche, Strukturproteinen, Impfstoff, Fruehproteine, Papillomviren, Epidermis, Antigen, T - Zellen, Peptiden, Impfstoff

DerHautarzt.60470739.ger.abstr_task2

Sentence: Humane Papillomviren ( HPV ) sind Ursache haeufiger epithelialer Proliferationen und an der Entstehung von anogenitalen Karzinomen wesentlich beteiligt . Bei der Entwicklung eines Impfstoffes gegen krebsassoziierte HPV wird infolge zweier grundsaetzlicher Ziele sowohl in Richtung der Prophylaxe als auch einer therapeutischen Anwendung gearbeitet . Eine Vakzine zur Verhinderung einer Infektion mit HPV scheint in naher Zukunft herstellbar . Antikoerper gegen dreidimensionale Kapsidstrukturen schuetzen im Tiermodell vor dem Eindringen der Papillomviren in die Wirtszelle , und diese wichtigen neutralisierenden Antikoerper koennen durch DNA-freie virusaehnliche Kapsidpartikel aus spontan rearrangierten Strukturproteinen induziert werden . Solche Partikel gelten deshalb als sicherer , prophylaktisch wirksamer Impfstoff . Eine ideale HPV-Vakzine sollte zusaetzlich die durch zellulaere Immunmechanismen vermittelte Rueckbildung von bereits bestehenden praekanzeroesen und auch von malignen Laesionen vermitteln . Die transformierenden Fruehproteine der Papillomviren , die in Basalzellen der Epidermis als ein hypothetisches Antigen spezifischer T-Zellen exprimiert sind , koennten in Form von synthetischen Peptiden fuer einen solchen Impfstoff eingesetzt werden . Instructions: please extract entity words from the input sentence

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Humane Papillomviren ( HPV ) sind Ursache haeufiger epithelialer Proliferationen und an der Entstehung von anogenitalen Karzinomen wesentlich beteiligt . Bei der Entwicklung eines Impfstoffes gegen krebsassoziierte HPV wird infolge zweier grundsaetzlicher Ziele sowohl in Richtung der Prophylaxe als auch einer therapeutischen Anwendung gearbeitet . Eine Vakzine zur Verhinderung einer Infektion mit HPV scheint in naher Zukunft herstellbar . Antikoerper gegen dreidimensionale Kapsidstrukturen schuetzen im Tiermodell vor dem Eindringen der Papillomviren in die Wirtszelle , und diese wichtigen neutralisierenden Antikoerper koennen durch DNA-freie virusaehnliche Kapsidpartikel aus spontan rearrangierten Strukturproteinen induziert werden . Solche Partikel gelten deshalb als sicherer , prophylaktisch wirksamer Impfstoff . Eine ideale HPV-Vakzine sollte zusaetzlich die durch zellulaere Immunmechanismen vermittelte Rueckbildung von bereits bestehenden praekanzeroesen und auch von malignen Laesionen vermitteln . Die transformierenden Fruehproteine der Papillomviren , die in Basalzellen der Epidermis als ein hypothetisches Antigen spezifischer T-Zellen exprimiert sind , koennten in Form von synthetischen Peptiden fuer einen solchen Impfstoff eingesetzt werden .

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[ "umlsterm" ]

Abstract is an umlsterm, clinical investigation is an umlsterm, sevoflurane is an umlsterm, degradation is an umlsterm, lithiumhydroxide is an umlsterm, carbon dioxide is an umlsterm, absorption is an umlsterm

DerAnaesthesist.00490106.eng.abstr_task0

Sentence: Abstract Aim of the study was the clinical investigation of sevoflurane degradation when using water-free lithiumhydroxide versus moist Draegersorb 800 for carbon dioxide absorption . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Abstract Aim of the study was the clinical investigation of sevoflurane degradation when using water-free lithiumhydroxide versus moist Draegersorb 800 for carbon dioxide absorption .

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[ "umlsterm" ]

Abstract is an umlsterm, clinical investigation is an umlsterm, sevoflurane is an umlsterm, degradation is an umlsterm, lithiumhydroxide is an umlsterm, carbon dioxide is an umlsterm, absorption is an umlsterm

DerAnaesthesist.00490106.eng.abstr_task1

Sentence: Abstract Aim of the study was the clinical investigation of sevoflurane degradation when using water-free lithiumhydroxide versus moist Draegersorb 800 for carbon dioxide absorption . Instructions: please typing these entity words according to sentence: Abstract, clinical investigation, sevoflurane, degradation, lithiumhydroxide, carbon dioxide, absorption Options: umlsterm

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Abstract Aim of the study was the clinical investigation of sevoflurane degradation when using water-free lithiumhydroxide versus moist Draegersorb 800 for carbon dioxide absorption .

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[ "umlsterm" ]

Abstract, clinical investigation, sevoflurane, degradation, lithiumhydroxide, carbon dioxide, absorption

DerAnaesthesist.00490106.eng.abstr_task2

Sentence: Abstract Aim of the study was the clinical investigation of sevoflurane degradation when using water-free lithiumhydroxide versus moist Draegersorb 800 for carbon dioxide absorption . Instructions: please extract entity words from the input sentence

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Abstract Aim of the study was the clinical investigation of sevoflurane degradation when using water-free lithiumhydroxide versus moist Draegersorb 800 for carbon dioxide absorption .

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[ "umlsterm" ]

K - ras is a Protein, K - ras is a Protein, K - ras is a Protein, K - ras is a Protein, K - ras is a Protein

531_task0

Sentence: Beta 1-6 branching of N-linked carbohydrate is associated with K-ras mutation in human colon carcinoma cell lines. Here the K-ras genotypes of nine colon carcinoma cell lines are compared to the protein glycosylation patterns found in these cells. By a variety of methodologies utilizing lectins to probe carbohydrate structure, we find evidence that five out of six cell lines having K-ras mutations have elevated amounts of beta 1-6 branching at the trimannosyl core of N-linked carbohydrate. None of the three K-ras wild type cell lines assayed have evidence of elevated beta 1-6 branching. In five out of five cell lines examined, the amount of beta 1-6 branching correlates with the extent of cellular ras-GTP elevation and supports the hypothesis that expression of beta 1-6 branching in colon carcinoma cell lines is quantitatively linked to K-ras activation. These results are discussed in the context of the ras-signalling pathway. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein

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Beta 1-6 branching of N-linked carbohydrate is associated with K-ras mutation in human colon carcinoma cell lines. Here the K-ras genotypes of nine colon carcinoma cell lines are compared to the protein glycosylation patterns found in these cells. By a variety of methodologies utilizing lectins to probe carbohydrate structure, we find evidence that five out of six cell lines having K-ras mutations have elevated amounts of beta 1-6 branching at the trimannosyl core of N-linked carbohydrate. None of the three K-ras wild type cell lines assayed have evidence of elevated beta 1-6 branching. In five out of five cell lines examined, the amount of beta 1-6 branching correlates with the extent of cellular ras-GTP elevation and supports the hypothesis that expression of beta 1-6 branching in colon carcinoma cell lines is quantitatively linked to K-ras activation. These results are discussed in the context of the ras-signalling pathway.

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[ "Protein" ]

K - ras is a Protein, K - ras is a Protein, K - ras is a Protein, K - ras is a Protein, K - ras is a Protein

531_task1

Sentence: Beta 1-6 branching of N-linked carbohydrate is associated with K-ras mutation in human colon carcinoma cell lines. Here the K-ras genotypes of nine colon carcinoma cell lines are compared to the protein glycosylation patterns found in these cells. By a variety of methodologies utilizing lectins to probe carbohydrate structure, we find evidence that five out of six cell lines having K-ras mutations have elevated amounts of beta 1-6 branching at the trimannosyl core of N-linked carbohydrate. None of the three K-ras wild type cell lines assayed have evidence of elevated beta 1-6 branching. In five out of five cell lines examined, the amount of beta 1-6 branching correlates with the extent of cellular ras-GTP elevation and supports the hypothesis that expression of beta 1-6 branching in colon carcinoma cell lines is quantitatively linked to K-ras activation. These results are discussed in the context of the ras-signalling pathway. Instructions: please typing these entity words according to sentence: K - ras, K - ras, K - ras, K - ras, K - ras Options: Protein

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Beta 1-6 branching of N-linked carbohydrate is associated with K-ras mutation in human colon carcinoma cell lines. Here the K-ras genotypes of nine colon carcinoma cell lines are compared to the protein glycosylation patterns found in these cells. By a variety of methodologies utilizing lectins to probe carbohydrate structure, we find evidence that five out of six cell lines having K-ras mutations have elevated amounts of beta 1-6 branching at the trimannosyl core of N-linked carbohydrate. None of the three K-ras wild type cell lines assayed have evidence of elevated beta 1-6 branching. In five out of five cell lines examined, the amount of beta 1-6 branching correlates with the extent of cellular ras-GTP elevation and supports the hypothesis that expression of beta 1-6 branching in colon carcinoma cell lines is quantitatively linked to K-ras activation. These results are discussed in the context of the ras-signalling pathway.

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[ "Protein" ]

K - ras, K - ras, K - ras, K - ras, K - ras

531_task2

Sentence: Beta 1-6 branching of N-linked carbohydrate is associated with K-ras mutation in human colon carcinoma cell lines. Here the K-ras genotypes of nine colon carcinoma cell lines are compared to the protein glycosylation patterns found in these cells. By a variety of methodologies utilizing lectins to probe carbohydrate structure, we find evidence that five out of six cell lines having K-ras mutations have elevated amounts of beta 1-6 branching at the trimannosyl core of N-linked carbohydrate. None of the three K-ras wild type cell lines assayed have evidence of elevated beta 1-6 branching. In five out of five cell lines examined, the amount of beta 1-6 branching correlates with the extent of cellular ras-GTP elevation and supports the hypothesis that expression of beta 1-6 branching in colon carcinoma cell lines is quantitatively linked to K-ras activation. These results are discussed in the context of the ras-signalling pathway. Instructions: please extract entity words from the input sentence

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Beta 1-6 branching of N-linked carbohydrate is associated with K-ras mutation in human colon carcinoma cell lines. Here the K-ras genotypes of nine colon carcinoma cell lines are compared to the protein glycosylation patterns found in these cells. By a variety of methodologies utilizing lectins to probe carbohydrate structure, we find evidence that five out of six cell lines having K-ras mutations have elevated amounts of beta 1-6 branching at the trimannosyl core of N-linked carbohydrate. None of the three K-ras wild type cell lines assayed have evidence of elevated beta 1-6 branching. In five out of five cell lines examined, the amount of beta 1-6 branching correlates with the extent of cellular ras-GTP elevation and supports the hypothesis that expression of beta 1-6 branching in colon carcinoma cell lines is quantitatively linked to K-ras activation. These results are discussed in the context of the ras-signalling pathway.

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[ "Protein" ]

use is an umlsterm, argon - laser is an umlsterm, coagulation is an umlsterm, retinal arteries is an umlsterm

DerOpthalmologe.70940724.eng.abstr_task0

Sentence: By the use of a new online measuring system the effect of argon-laser coagulation in diabetics on the diameters of retinal arteries was measured . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O" ]

By the use of a new online measuring system the effect of argon-laser coagulation in diabetics on the diameters of retinal arteries was measured .

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[ "umlsterm" ]

use is an umlsterm, argon - laser is an umlsterm, coagulation is an umlsterm, retinal arteries is an umlsterm

DerOpthalmologe.70940724.eng.abstr_task1

Sentence: By the use of a new online measuring system the effect of argon-laser coagulation in diabetics on the diameters of retinal arteries was measured . Instructions: please typing these entity words according to sentence: use, argon - laser, coagulation, retinal arteries Options: umlsterm

[ "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O" ]

By the use of a new online measuring system the effect of argon-laser coagulation in diabetics on the diameters of retinal arteries was measured .

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[ "umlsterm" ]

use, argon - laser, coagulation, retinal arteries

DerOpthalmologe.70940724.eng.abstr_task2

Sentence: By the use of a new online measuring system the effect of argon-laser coagulation in diabetics on the diameters of retinal arteries was measured . Instructions: please extract entity words from the input sentence

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By the use of a new online measuring system the effect of argon-laser coagulation in diabetics on the diameters of retinal arteries was measured .

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[ "umlsterm" ]

Clonidine is a Intervention_Pharmacological, metabolic control in type 2 diabetic patients is a Outcome_Physical, ophthalmic is a Participant_Condition, clonidine is a Intervention_Pharmacological, blood glucose control is a Outcome_Physical, insulin requirements is a Outcome_Physical, flunitrazepam is a Intervention_Pharmacological, Blood glucose concentrations is a Outcome_Physical, Plasma C - peptide and counter - regulatory hormones is a Outcome_Physical, Glycaemia is a Outcome_Physical, median amount of insulin administered is a Outcome_Physical, Plasma catecholamine concentrations is a Outcome_Physical, cortisol concentrations . is a Outcome_Physical

12502_task0

Sentence: Clonidine premedication improves metabolic control in type 2 diabetic patients during ophthalmic surgery . BACKGROUND In stressful conditions , increasing blood glucose concentrations are closely related to an increase in catecholamines and cortisol release . Clonidine , a centrally acting alpha ( 2 ) -adrenoceptor agonist , has neuroendocrine effects , including inhibition of sympathoadrenal activity . We therefore evaluated the effect of clonidine on blood glucose control and insulin requirements during ophthalmic surgery when given as premedication in type 2 diabetic patients . METHODS After randomization , patients were premedicated with clonidine or flunitrazepam ( control ) . Patients were given insulin by continuous i.v . infusion to maintain blood glucose in the range 5.5-11.1 mmol litre ( -1 ) . Blood glucose concentrations were measured every 15 min during surgery , and hourly for 6 h after surgery . Plasma C-peptide and counter-regulatory hormones were also measured . RESULTS Glycaemia was significantly lower in the clonidine group ( P < 0.01 ) and the median amount of insulin administered was significantly reduced : clonidine group 9.0 ( interquartile range 5.1 ) units ; control 18.6 ( 10.2 ) units ; P < 0.01 ) . Plasma catecholamine concentrations were lower in patients given clonidine ( P < 0.05 ) but there was no difference in cortisol concentrations . CONCLUSION Premedication of type 2 diabetic patients with clonidine 90 min before surgery improves blood glucose control and decreases insulin requirements during ophthalmic surgery . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Outcome_Physical, Participant_Condition

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Clonidine premedication improves metabolic control in type 2 diabetic patients during ophthalmic surgery . BACKGROUND In stressful conditions , increasing blood glucose concentrations are closely related to an increase in catecholamines and cortisol release . Clonidine , a centrally acting alpha ( 2 ) -adrenoceptor agonist , has neuroendocrine effects , including inhibition of sympathoadrenal activity . We therefore evaluated the effect of clonidine on blood glucose control and insulin requirements during ophthalmic surgery when given as premedication in type 2 diabetic patients . METHODS After randomization , patients were premedicated with clonidine or flunitrazepam ( control ) . Patients were given insulin by continuous i.v . infusion to maintain blood glucose in the range 5.5-11.1 mmol litre ( -1 ) . Blood glucose concentrations were measured every 15 min during surgery , and hourly for 6 h after surgery . Plasma C-peptide and counter-regulatory hormones were also measured . RESULTS Glycaemia was significantly lower in the clonidine group ( P < 0.01 ) and the median amount of insulin administered was significantly reduced : clonidine group 9.0 ( interquartile range 5.1 ) units ; control 18.6 ( 10.2 ) units ; P < 0.01 ) . Plasma catecholamine concentrations were lower in patients given clonidine ( P < 0.05 ) but there was no difference in cortisol concentrations . CONCLUSION Premedication of type 2 diabetic patients with clonidine 90 min before surgery improves blood glucose control and decreases insulin requirements during ophthalmic surgery .

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[ "Outcome_Physical", "Participant_Condition", "Intervention_Pharmacological" ]

Clonidine is a Intervention_Pharmacological, metabolic control in type 2 diabetic patients is a Outcome_Physical, ophthalmic is a Participant_Condition, clonidine is a Intervention_Pharmacological, blood glucose control is a Outcome_Physical, insulin requirements is a Outcome_Physical, flunitrazepam is a Intervention_Pharmacological, Blood glucose concentrations is a Outcome_Physical, Plasma C - peptide and counter - regulatory hormones is a Outcome_Physical, Glycaemia is a Outcome_Physical, median amount of insulin administered is a Outcome_Physical, Plasma catecholamine concentrations is a Outcome_Physical, cortisol concentrations . is a Outcome_Physical

12502_task1

Sentence: Clonidine premedication improves metabolic control in type 2 diabetic patients during ophthalmic surgery . BACKGROUND In stressful conditions , increasing blood glucose concentrations are closely related to an increase in catecholamines and cortisol release . Clonidine , a centrally acting alpha ( 2 ) -adrenoceptor agonist , has neuroendocrine effects , including inhibition of sympathoadrenal activity . We therefore evaluated the effect of clonidine on blood glucose control and insulin requirements during ophthalmic surgery when given as premedication in type 2 diabetic patients . METHODS After randomization , patients were premedicated with clonidine or flunitrazepam ( control ) . Patients were given insulin by continuous i.v . infusion to maintain blood glucose in the range 5.5-11.1 mmol litre ( -1 ) . Blood glucose concentrations were measured every 15 min during surgery , and hourly for 6 h after surgery . Plasma C-peptide and counter-regulatory hormones were also measured . RESULTS Glycaemia was significantly lower in the clonidine group ( P < 0.01 ) and the median amount of insulin administered was significantly reduced : clonidine group 9.0 ( interquartile range 5.1 ) units ; control 18.6 ( 10.2 ) units ; P < 0.01 ) . Plasma catecholamine concentrations were lower in patients given clonidine ( P < 0.05 ) but there was no difference in cortisol concentrations . CONCLUSION Premedication of type 2 diabetic patients with clonidine 90 min before surgery improves blood glucose control and decreases insulin requirements during ophthalmic surgery . Instructions: please typing these entity words according to sentence: Clonidine, metabolic control in type 2 diabetic patients, ophthalmic, clonidine, blood glucose control, insulin requirements, flunitrazepam, Blood glucose concentrations, Plasma C - peptide and counter - regulatory hormones, Glycaemia, median amount of insulin administered, Plasma catecholamine concentrations, cortisol concentrations . Options: Intervention_Pharmacological, Outcome_Physical, Participant_Condition

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Clonidine premedication improves metabolic control in type 2 diabetic patients during ophthalmic surgery . BACKGROUND In stressful conditions , increasing blood glucose concentrations are closely related to an increase in catecholamines and cortisol release . Clonidine , a centrally acting alpha ( 2 ) -adrenoceptor agonist , has neuroendocrine effects , including inhibition of sympathoadrenal activity . We therefore evaluated the effect of clonidine on blood glucose control and insulin requirements during ophthalmic surgery when given as premedication in type 2 diabetic patients . METHODS After randomization , patients were premedicated with clonidine or flunitrazepam ( control ) . Patients were given insulin by continuous i.v . infusion to maintain blood glucose in the range 5.5-11.1 mmol litre ( -1 ) . Blood glucose concentrations were measured every 15 min during surgery , and hourly for 6 h after surgery . Plasma C-peptide and counter-regulatory hormones were also measured . RESULTS Glycaemia was significantly lower in the clonidine group ( P < 0.01 ) and the median amount of insulin administered was significantly reduced : clonidine group 9.0 ( interquartile range 5.1 ) units ; control 18.6 ( 10.2 ) units ; P < 0.01 ) . Plasma catecholamine concentrations were lower in patients given clonidine ( P < 0.05 ) but there was no difference in cortisol concentrations . CONCLUSION Premedication of type 2 diabetic patients with clonidine 90 min before surgery improves blood glucose control and decreases insulin requirements during ophthalmic surgery .

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[ "Outcome_Physical", "Participant_Condition", "Intervention_Pharmacological" ]

Clonidine, metabolic control in type 2 diabetic patients, ophthalmic, clonidine, blood glucose control, insulin requirements, flunitrazepam, Blood glucose concentrations, Plasma C - peptide and counter - regulatory hormones, Glycaemia, median amount of insulin administered, Plasma catecholamine concentrations, cortisol concentrations .

12502_task2

Sentence: Clonidine premedication improves metabolic control in type 2 diabetic patients during ophthalmic surgery . BACKGROUND In stressful conditions , increasing blood glucose concentrations are closely related to an increase in catecholamines and cortisol release . Clonidine , a centrally acting alpha ( 2 ) -adrenoceptor agonist , has neuroendocrine effects , including inhibition of sympathoadrenal activity . We therefore evaluated the effect of clonidine on blood glucose control and insulin requirements during ophthalmic surgery when given as premedication in type 2 diabetic patients . METHODS After randomization , patients were premedicated with clonidine or flunitrazepam ( control ) . Patients were given insulin by continuous i.v . infusion to maintain blood glucose in the range 5.5-11.1 mmol litre ( -1 ) . Blood glucose concentrations were measured every 15 min during surgery , and hourly for 6 h after surgery . Plasma C-peptide and counter-regulatory hormones were also measured . RESULTS Glycaemia was significantly lower in the clonidine group ( P < 0.01 ) and the median amount of insulin administered was significantly reduced : clonidine group 9.0 ( interquartile range 5.1 ) units ; control 18.6 ( 10.2 ) units ; P < 0.01 ) . Plasma catecholamine concentrations were lower in patients given clonidine ( P < 0.05 ) but there was no difference in cortisol concentrations . CONCLUSION Premedication of type 2 diabetic patients with clonidine 90 min before surgery improves blood glucose control and decreases insulin requirements during ophthalmic surgery . Instructions: please extract entity words from the input sentence

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Clonidine premedication improves metabolic control in type 2 diabetic patients during ophthalmic surgery . BACKGROUND In stressful conditions , increasing blood glucose concentrations are closely related to an increase in catecholamines and cortisol release . Clonidine , a centrally acting alpha ( 2 ) -adrenoceptor agonist , has neuroendocrine effects , including inhibition of sympathoadrenal activity . We therefore evaluated the effect of clonidine on blood glucose control and insulin requirements during ophthalmic surgery when given as premedication in type 2 diabetic patients . METHODS After randomization , patients were premedicated with clonidine or flunitrazepam ( control ) . Patients were given insulin by continuous i.v . infusion to maintain blood glucose in the range 5.5-11.1 mmol litre ( -1 ) . Blood glucose concentrations were measured every 15 min during surgery , and hourly for 6 h after surgery . Plasma C-peptide and counter-regulatory hormones were also measured . RESULTS Glycaemia was significantly lower in the clonidine group ( P < 0.01 ) and the median amount of insulin administered was significantly reduced : clonidine group 9.0 ( interquartile range 5.1 ) units ; control 18.6 ( 10.2 ) units ; P < 0.01 ) . Plasma catecholamine concentrations were lower in patients given clonidine ( P < 0.05 ) but there was no difference in cortisol concentrations . CONCLUSION Premedication of type 2 diabetic patients with clonidine 90 min before surgery improves blood glucose control and decreases insulin requirements during ophthalmic surgery .

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[ "Outcome_Physical", "Participant_Condition", "Intervention_Pharmacological" ]

Hydatid disease is an umlsterm, parasitic is an umlsterm, tapeworm is an umlsterm, Echinococcus is an umlsterm, stage is an umlsterm, parasite is an umlsterm, liver is an umlsterm, bone is an umlsterm, accounting is an umlsterm, hip joint is an umlsterm, os pubis is an umlsterm, ileum is an umlsterm, femoral head is an umlsterm, Recurrence is an umlsterm, hydatid cyst is an umlsterm, groin is an umlsterm, femur is an umlsterm, total hip replacement is an umlsterm, polyacetal is an umlsterm, device is an umlsterm, aid is an umlsterm, CAD is an umlsterm, techniques is an umlsterm, surgical procedure is an umlsterm, chemotherapy is an umlsterm, mebendazole is an umlsterm, hydatid disease is an umlsterm

DerChirurg.70680832.eng.abstr_task0

Sentence: Hydatid disease is caused by the parasitic tapeworm Echinococcus . The larval stage of this parasite can thrive in many parts of the body , most frequently in the liver . Primary bone location is very rare , accounting for less than 2 % of all hydatid lesions . We report on a case of left-sided extended pelvic infestation . The destruction of the hip joint , os pubis , large parts of the ileum and the femoral head made pelvic resection and prosthetic replacement necessary . Recurrence of a hydatid cyst 5 years later in the left groin originating from the proximal femur was treated with second femoral resection and new total hip replacement . Because of instability , the primarily inserted polyacetal pelvic replacement had to be exchanged for a custom-made device fabricated with the aid of computer-aided design ( CAD ) techniques . This surgical procedure was combined with chemotherapy ( mebendazole ) . The necessity of radical resection in osseus hydatid disease is discussed . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Hydatid disease is caused by the parasitic tapeworm Echinococcus . The larval stage of this parasite can thrive in many parts of the body , most frequently in the liver . Primary bone location is very rare , accounting for less than 2 % of all hydatid lesions . We report on a case of left-sided extended pelvic infestation . The destruction of the hip joint , os pubis , large parts of the ileum and the femoral head made pelvic resection and prosthetic replacement necessary . Recurrence of a hydatid cyst 5 years later in the left groin originating from the proximal femur was treated with second femoral resection and new total hip replacement . Because of instability , the primarily inserted polyacetal pelvic replacement had to be exchanged for a custom-made device fabricated with the aid of computer-aided design ( CAD ) techniques . This surgical procedure was combined with chemotherapy ( mebendazole ) . The necessity of radical resection in osseus hydatid disease is discussed .

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[ "umlsterm" ]

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DerChirurg.70680832.eng.abstr_task1

Sentence: Hydatid disease is caused by the parasitic tapeworm Echinococcus . The larval stage of this parasite can thrive in many parts of the body , most frequently in the liver . Primary bone location is very rare , accounting for less than 2 % of all hydatid lesions . We report on a case of left-sided extended pelvic infestation . The destruction of the hip joint , os pubis , large parts of the ileum and the femoral head made pelvic resection and prosthetic replacement necessary . Recurrence of a hydatid cyst 5 years later in the left groin originating from the proximal femur was treated with second femoral resection and new total hip replacement . Because of instability , the primarily inserted polyacetal pelvic replacement had to be exchanged for a custom-made device fabricated with the aid of computer-aided design ( CAD ) techniques . This surgical procedure was combined with chemotherapy ( mebendazole ) . The necessity of radical resection in osseus hydatid disease is discussed . Instructions: please typing these entity words according to sentence: Hydatid disease, parasitic, tapeworm, Echinococcus, stage, parasite, liver, bone, accounting, hip joint, os pubis, ileum, femoral head, Recurrence, hydatid cyst, groin, femur, total hip replacement, polyacetal, device, aid, CAD, techniques, surgical procedure, chemotherapy, mebendazole, hydatid disease Options: umlsterm

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Hydatid disease is caused by the parasitic tapeworm Echinococcus . The larval stage of this parasite can thrive in many parts of the body , most frequently in the liver . Primary bone location is very rare , accounting for less than 2 % of all hydatid lesions . We report on a case of left-sided extended pelvic infestation . The destruction of the hip joint , os pubis , large parts of the ileum and the femoral head made pelvic resection and prosthetic replacement necessary . Recurrence of a hydatid cyst 5 years later in the left groin originating from the proximal femur was treated with second femoral resection and new total hip replacement . Because of instability , the primarily inserted polyacetal pelvic replacement had to be exchanged for a custom-made device fabricated with the aid of computer-aided design ( CAD ) techniques . This surgical procedure was combined with chemotherapy ( mebendazole ) . The necessity of radical resection in osseus hydatid disease is discussed .

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[ "umlsterm" ]

Hydatid disease, parasitic, tapeworm, Echinococcus, stage, parasite, liver, bone, accounting, hip joint, os pubis, ileum, femoral head, Recurrence, hydatid cyst, groin, femur, total hip replacement, polyacetal, device, aid, CAD, techniques, surgical procedure, chemotherapy, mebendazole, hydatid disease

DerChirurg.70680832.eng.abstr_task2

Sentence: Hydatid disease is caused by the parasitic tapeworm Echinococcus . The larval stage of this parasite can thrive in many parts of the body , most frequently in the liver . Primary bone location is very rare , accounting for less than 2 % of all hydatid lesions . We report on a case of left-sided extended pelvic infestation . The destruction of the hip joint , os pubis , large parts of the ileum and the femoral head made pelvic resection and prosthetic replacement necessary . Recurrence of a hydatid cyst 5 years later in the left groin originating from the proximal femur was treated with second femoral resection and new total hip replacement . Because of instability , the primarily inserted polyacetal pelvic replacement had to be exchanged for a custom-made device fabricated with the aid of computer-aided design ( CAD ) techniques . This surgical procedure was combined with chemotherapy ( mebendazole ) . The necessity of radical resection in osseus hydatid disease is discussed . Instructions: please extract entity words from the input sentence

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Hydatid disease is caused by the parasitic tapeworm Echinococcus . The larval stage of this parasite can thrive in many parts of the body , most frequently in the liver . Primary bone location is very rare , accounting for less than 2 % of all hydatid lesions . We report on a case of left-sided extended pelvic infestation . The destruction of the hip joint , os pubis , large parts of the ileum and the femoral head made pelvic resection and prosthetic replacement necessary . Recurrence of a hydatid cyst 5 years later in the left groin originating from the proximal femur was treated with second femoral resection and new total hip replacement . Because of instability , the primarily inserted polyacetal pelvic replacement had to be exchanged for a custom-made device fabricated with the aid of computer-aided design ( CAD ) techniques . This surgical procedure was combined with chemotherapy ( mebendazole ) . The necessity of radical resection in osseus hydatid disease is discussed .

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[ "umlsterm" ]

knowledge is an umlsterm, physiology is an umlsterm, pathophysiology is an umlsterm, male is an umlsterm, erectile dysfunction is an umlsterm, etiology - based is an umlsterm, therapies is an umlsterm, period is an umlsterm, behavior is an umlsterm, hand is an umlsterm, life - span is an umlsterm, resources is an umlsterm, therapies is an umlsterm, Sexology is an umlsterm, men is an umlsterm, interdisciplinary research is an umlsterm, therapeutic is an umlsterm, patients is an umlsterm, recognition is an umlsterm, treatment is an umlsterm, sildenafil is an umlsterm, sexual counseling is an umlsterm, therapy is an umlsterm, elderly is an umlsterm, patients is an umlsterm, sexology is an umlsterm, male is an umlsterm, behavior is an umlsterm, self - understanding is an umlsterm, senescence is an umlsterm, sexual dysfunction is an umlsterm, therapeutic is an umlsterm, plans is an umlsterm, behaviour- is an umlsterm, counseling is an umlsterm

Reproduktionsmedizin.90150133.eng.abstr_task0

Sentence: During the past 15 years urologists have acquired a widespread knowledge on physiology and pathophysiology of male erectile dysfunction and consequent etiology-based therapies . The same period was characterized by a profound change of sexual behavior and public appearance of sexual issues . On the other hand the socio-demographic effects of prolonged life-span and reduced socio-economic resources for reimbursement of medical therapies become visible . Sexology of aging men is an interdisciplinary research field ; its scientific results should be included into therapeutic decisions in impotent patients . Especially in recognition of our new treatment options such as oral sildenafil , a partner- and libido-oriented sexual counseling should accompany somatic therapy in most of our elderly patients . There exists no general " sexology of the aging male " but rather an individual sexual behavior and self-understanding that is transported into senescence . " Zeitgeist " -phenomena , partner problems and age-dependent physiologic changes can coincide and potentiate the resulting sexual dysfunction . Modern therapeutic plans should recognize these facts and create behaviour- and partner-oriented counseling strategies combined with minimally invasive somatic approaches . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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During the past 15 years urologists have acquired a widespread knowledge on physiology and pathophysiology of male erectile dysfunction and consequent etiology-based therapies . The same period was characterized by a profound change of sexual behavior and public appearance of sexual issues . On the other hand the socio-demographic effects of prolonged life-span and reduced socio-economic resources for reimbursement of medical therapies become visible . Sexology of aging men is an interdisciplinary research field ; its scientific results should be included into therapeutic decisions in impotent patients . Especially in recognition of our new treatment options such as oral sildenafil , a partner- and libido-oriented sexual counseling should accompany somatic therapy in most of our elderly patients . There exists no general " sexology of the aging male " but rather an individual sexual behavior and self-understanding that is transported into senescence . " Zeitgeist " -phenomena , partner problems and age-dependent physiologic changes can coincide and potentiate the resulting sexual dysfunction . Modern therapeutic plans should recognize these facts and create behaviour- and partner-oriented counseling strategies combined with minimally invasive somatic approaches .

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[ "umlsterm" ]

knowledge is an umlsterm, physiology is an umlsterm, pathophysiology is an umlsterm, male is an umlsterm, erectile dysfunction is an umlsterm, etiology - based is an umlsterm, therapies is an umlsterm, period is an umlsterm, behavior is an umlsterm, hand is an umlsterm, life - span is an umlsterm, resources is an umlsterm, therapies is an umlsterm, Sexology is an umlsterm, men is an umlsterm, interdisciplinary research is an umlsterm, therapeutic is an umlsterm, patients is an umlsterm, recognition is an umlsterm, treatment is an umlsterm, sildenafil is an umlsterm, sexual counseling is an umlsterm, therapy is an umlsterm, elderly is an umlsterm, patients is an umlsterm, sexology is an umlsterm, male is an umlsterm, behavior is an umlsterm, self - understanding is an umlsterm, senescence is an umlsterm, sexual dysfunction is an umlsterm, therapeutic is an umlsterm, plans is an umlsterm, behaviour- is an umlsterm, counseling is an umlsterm

Reproduktionsmedizin.90150133.eng.abstr_task1

Sentence: During the past 15 years urologists have acquired a widespread knowledge on physiology and pathophysiology of male erectile dysfunction and consequent etiology-based therapies . The same period was characterized by a profound change of sexual behavior and public appearance of sexual issues . On the other hand the socio-demographic effects of prolonged life-span and reduced socio-economic resources for reimbursement of medical therapies become visible . Sexology of aging men is an interdisciplinary research field ; its scientific results should be included into therapeutic decisions in impotent patients . Especially in recognition of our new treatment options such as oral sildenafil , a partner- and libido-oriented sexual counseling should accompany somatic therapy in most of our elderly patients . There exists no general " sexology of the aging male " but rather an individual sexual behavior and self-understanding that is transported into senescence . " Zeitgeist " -phenomena , partner problems and age-dependent physiologic changes can coincide and potentiate the resulting sexual dysfunction . Modern therapeutic plans should recognize these facts and create behaviour- and partner-oriented counseling strategies combined with minimally invasive somatic approaches . Instructions: please typing these entity words according to sentence: knowledge, physiology, pathophysiology, male, erectile dysfunction, etiology - based, therapies, period, behavior, hand, life - span, resources, therapies, Sexology, men, interdisciplinary research, therapeutic, patients, recognition, treatment, sildenafil, sexual counseling, therapy, elderly, patients, sexology, male, behavior, self - understanding, senescence, sexual dysfunction, therapeutic, plans, behaviour-, counseling Options: umlsterm

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During the past 15 years urologists have acquired a widespread knowledge on physiology and pathophysiology of male erectile dysfunction and consequent etiology-based therapies . The same period was characterized by a profound change of sexual behavior and public appearance of sexual issues . On the other hand the socio-demographic effects of prolonged life-span and reduced socio-economic resources for reimbursement of medical therapies become visible . Sexology of aging men is an interdisciplinary research field ; its scientific results should be included into therapeutic decisions in impotent patients . Especially in recognition of our new treatment options such as oral sildenafil , a partner- and libido-oriented sexual counseling should accompany somatic therapy in most of our elderly patients . There exists no general " sexology of the aging male " but rather an individual sexual behavior and self-understanding that is transported into senescence . " Zeitgeist " -phenomena , partner problems and age-dependent physiologic changes can coincide and potentiate the resulting sexual dysfunction . Modern therapeutic plans should recognize these facts and create behaviour- and partner-oriented counseling strategies combined with minimally invasive somatic approaches .

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[ "umlsterm" ]

knowledge, physiology, pathophysiology, male, erectile dysfunction, etiology - based, therapies, period, behavior, hand, life - span, resources, therapies, Sexology, men, interdisciplinary research, therapeutic, patients, recognition, treatment, sildenafil, sexual counseling, therapy, elderly, patients, sexology, male, behavior, self - understanding, senescence, sexual dysfunction, therapeutic, plans, behaviour-, counseling

Reproduktionsmedizin.90150133.eng.abstr_task2

Sentence: During the past 15 years urologists have acquired a widespread knowledge on physiology and pathophysiology of male erectile dysfunction and consequent etiology-based therapies . The same period was characterized by a profound change of sexual behavior and public appearance of sexual issues . On the other hand the socio-demographic effects of prolonged life-span and reduced socio-economic resources for reimbursement of medical therapies become visible . Sexology of aging men is an interdisciplinary research field ; its scientific results should be included into therapeutic decisions in impotent patients . Especially in recognition of our new treatment options such as oral sildenafil , a partner- and libido-oriented sexual counseling should accompany somatic therapy in most of our elderly patients . There exists no general " sexology of the aging male " but rather an individual sexual behavior and self-understanding that is transported into senescence . " Zeitgeist " -phenomena , partner problems and age-dependent physiologic changes can coincide and potentiate the resulting sexual dysfunction . Modern therapeutic plans should recognize these facts and create behaviour- and partner-oriented counseling strategies combined with minimally invasive somatic approaches . Instructions: please extract entity words from the input sentence

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During the past 15 years urologists have acquired a widespread knowledge on physiology and pathophysiology of male erectile dysfunction and consequent etiology-based therapies . The same period was characterized by a profound change of sexual behavior and public appearance of sexual issues . On the other hand the socio-demographic effects of prolonged life-span and reduced socio-economic resources for reimbursement of medical therapies become visible . Sexology of aging men is an interdisciplinary research field ; its scientific results should be included into therapeutic decisions in impotent patients . Especially in recognition of our new treatment options such as oral sildenafil , a partner- and libido-oriented sexual counseling should accompany somatic therapy in most of our elderly patients . There exists no general " sexology of the aging male " but rather an individual sexual behavior and self-understanding that is transported into senescence . " Zeitgeist " -phenomena , partner problems and age-dependent physiologic changes can coincide and potentiate the resulting sexual dysfunction . Modern therapeutic plans should recognize these facts and create behaviour- and partner-oriented counseling strategies combined with minimally invasive somatic approaches .

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[ "umlsterm" ]

Pocket proteins is a Gene_or_gene_product, retinoblastoma protein is a Gene_or_gene_product, pRB is a Gene_or_gene_product, pRB is a Gene_or_gene_product, p107 is a Gene_or_gene_product, p130 is a Gene_or_gene_product, pocket protein is a Gene_or_gene_product, E2F is a Gene_or_gene_product, pRB is a Gene_or_gene_product, p107 is a Gene_or_gene_product, p130 is a Gene_or_gene_product, E2Fs is a Gene_or_gene_product, E2F is a Gene_or_gene_product, pocket proteins is a Gene_or_gene_product, Pocket proteins is a Gene_or_gene_product, E2F is a Gene_or_gene_product, Cdk2 is a Gene_or_gene_product, pocket protein is a Gene_or_gene_product, pocket protein is a Gene_or_gene_product, pocket proteins is a Gene_or_gene_product, pocket proteins is a Gene_or_gene_product

141_task0

Sentence: Pocket proteins and cell cycle control. The retinoblastoma protein (pRB) and the pRB-related p107 and p130 comprise the 'pocket protein' family of cell cycle regulators. These proteins are best known for their roles in restraining the G1-S transition through the regulation of E2F-responsive genes. pRB and the p107/p130 pair are required for the repression of distinct sets of genes, potentially due to their selective interactions with E2Fs that are engaged at specific promoter elements. In addition to regulating E2F-responsive genes in a reversible manner, pocket proteins contribute to silencing of such genes in cells that are undergoing senescence or differentiation. Pocket proteins also affect the G1-S transition through E2F-independent mechanisms, such as by inhibiting Cdk2 or by stabilizing p27(Kip1), and they are implicated in the control of G0 exit, the spatial organization of replication, and genomic rereplication. New insights into pocket protein regulation have also been obtained. Kinases previously thought to be crucial to pocket protein phosphorylation have been shown to be redundant, and new modes of phosphorylation and dephosphorylation have been identified. Despite these advances, much remains to be learned about the pocket proteins, particularly with regard to their developmental and tumor suppressor functions. Thus continues the story of the pocket proteins and the cell cycle. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Gene_or_gene_product

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Pocket proteins and cell cycle control. The retinoblastoma protein (pRB) and the pRB-related p107 and p130 comprise the 'pocket protein' family of cell cycle regulators. These proteins are best known for their roles in restraining the G1-S transition through the regulation of E2F-responsive genes. pRB and the p107/p130 pair are required for the repression of distinct sets of genes, potentially due to their selective interactions with E2Fs that are engaged at specific promoter elements. In addition to regulating E2F-responsive genes in a reversible manner, pocket proteins contribute to silencing of such genes in cells that are undergoing senescence or differentiation. Pocket proteins also affect the G1-S transition through E2F-independent mechanisms, such as by inhibiting Cdk2 or by stabilizing p27(Kip1), and they are implicated in the control of G0 exit, the spatial organization of replication, and genomic rereplication. New insights into pocket protein regulation have also been obtained. Kinases previously thought to be crucial to pocket protein phosphorylation have been shown to be redundant, and new modes of phosphorylation and dephosphorylation have been identified. Despite these advances, much remains to be learned about the pocket proteins, particularly with regard to their developmental and tumor suppressor functions. Thus continues the story of the pocket proteins and the cell cycle.

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[ "Gene_or_gene_product" ]

Pocket proteins is a Gene_or_gene_product, retinoblastoma protein is a Gene_or_gene_product, pRB is a Gene_or_gene_product, pRB is a Gene_or_gene_product, p107 is a Gene_or_gene_product, p130 is a Gene_or_gene_product, pocket protein is a Gene_or_gene_product, E2F is a Gene_or_gene_product, pRB is a Gene_or_gene_product, p107 is a Gene_or_gene_product, p130 is a Gene_or_gene_product, E2Fs is a Gene_or_gene_product, E2F is a Gene_or_gene_product, pocket proteins is a Gene_or_gene_product, Pocket proteins is a Gene_or_gene_product, E2F is a Gene_or_gene_product, Cdk2 is a Gene_or_gene_product, pocket protein is a Gene_or_gene_product, pocket protein is a Gene_or_gene_product, pocket proteins is a Gene_or_gene_product, pocket proteins is a Gene_or_gene_product

141_task1

Sentence: Pocket proteins and cell cycle control. The retinoblastoma protein (pRB) and the pRB-related p107 and p130 comprise the 'pocket protein' family of cell cycle regulators. These proteins are best known for their roles in restraining the G1-S transition through the regulation of E2F-responsive genes. pRB and the p107/p130 pair are required for the repression of distinct sets of genes, potentially due to their selective interactions with E2Fs that are engaged at specific promoter elements. In addition to regulating E2F-responsive genes in a reversible manner, pocket proteins contribute to silencing of such genes in cells that are undergoing senescence or differentiation. Pocket proteins also affect the G1-S transition through E2F-independent mechanisms, such as by inhibiting Cdk2 or by stabilizing p27(Kip1), and they are implicated in the control of G0 exit, the spatial organization of replication, and genomic rereplication. New insights into pocket protein regulation have also been obtained. Kinases previously thought to be crucial to pocket protein phosphorylation have been shown to be redundant, and new modes of phosphorylation and dephosphorylation have been identified. Despite these advances, much remains to be learned about the pocket proteins, particularly with regard to their developmental and tumor suppressor functions. Thus continues the story of the pocket proteins and the cell cycle. Instructions: please typing these entity words according to sentence: Pocket proteins, retinoblastoma protein, pRB, pRB, p107, p130, pocket protein, E2F, pRB, p107, p130, E2Fs, E2F, pocket proteins, Pocket proteins, E2F, Cdk2, pocket protein, pocket protein, pocket proteins, pocket proteins Options: Gene_or_gene_product

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Pocket proteins and cell cycle control. The retinoblastoma protein (pRB) and the pRB-related p107 and p130 comprise the 'pocket protein' family of cell cycle regulators. These proteins are best known for their roles in restraining the G1-S transition through the regulation of E2F-responsive genes. pRB and the p107/p130 pair are required for the repression of distinct sets of genes, potentially due to their selective interactions with E2Fs that are engaged at specific promoter elements. In addition to regulating E2F-responsive genes in a reversible manner, pocket proteins contribute to silencing of such genes in cells that are undergoing senescence or differentiation. Pocket proteins also affect the G1-S transition through E2F-independent mechanisms, such as by inhibiting Cdk2 or by stabilizing p27(Kip1), and they are implicated in the control of G0 exit, the spatial organization of replication, and genomic rereplication. New insights into pocket protein regulation have also been obtained. Kinases previously thought to be crucial to pocket protein phosphorylation have been shown to be redundant, and new modes of phosphorylation and dephosphorylation have been identified. Despite these advances, much remains to be learned about the pocket proteins, particularly with regard to their developmental and tumor suppressor functions. Thus continues the story of the pocket proteins and the cell cycle.

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[ "Gene_or_gene_product" ]

Pocket proteins, retinoblastoma protein, pRB, pRB, p107, p130, pocket protein, E2F, pRB, p107, p130, E2Fs, E2F, pocket proteins, Pocket proteins, E2F, Cdk2, pocket protein, pocket protein, pocket proteins, pocket proteins

141_task2

Sentence: Pocket proteins and cell cycle control. The retinoblastoma protein (pRB) and the pRB-related p107 and p130 comprise the 'pocket protein' family of cell cycle regulators. These proteins are best known for their roles in restraining the G1-S transition through the regulation of E2F-responsive genes. pRB and the p107/p130 pair are required for the repression of distinct sets of genes, potentially due to their selective interactions with E2Fs that are engaged at specific promoter elements. In addition to regulating E2F-responsive genes in a reversible manner, pocket proteins contribute to silencing of such genes in cells that are undergoing senescence or differentiation. Pocket proteins also affect the G1-S transition through E2F-independent mechanisms, such as by inhibiting Cdk2 or by stabilizing p27(Kip1), and they are implicated in the control of G0 exit, the spatial organization of replication, and genomic rereplication. New insights into pocket protein regulation have also been obtained. Kinases previously thought to be crucial to pocket protein phosphorylation have been shown to be redundant, and new modes of phosphorylation and dephosphorylation have been identified. Despite these advances, much remains to be learned about the pocket proteins, particularly with regard to their developmental and tumor suppressor functions. Thus continues the story of the pocket proteins and the cell cycle. Instructions: please extract entity words from the input sentence

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Pocket proteins and cell cycle control. The retinoblastoma protein (pRB) and the pRB-related p107 and p130 comprise the 'pocket protein' family of cell cycle regulators. These proteins are best known for their roles in restraining the G1-S transition through the regulation of E2F-responsive genes. pRB and the p107/p130 pair are required for the repression of distinct sets of genes, potentially due to their selective interactions with E2Fs that are engaged at specific promoter elements. In addition to regulating E2F-responsive genes in a reversible manner, pocket proteins contribute to silencing of such genes in cells that are undergoing senescence or differentiation. Pocket proteins also affect the G1-S transition through E2F-independent mechanisms, such as by inhibiting Cdk2 or by stabilizing p27(Kip1), and they are implicated in the control of G0 exit, the spatial organization of replication, and genomic rereplication. New insights into pocket protein regulation have also been obtained. Kinases previously thought to be crucial to pocket protein phosphorylation have been shown to be redundant, and new modes of phosphorylation and dephosphorylation have been identified. Despite these advances, much remains to be learned about the pocket proteins, particularly with regard to their developmental and tumor suppressor functions. Thus continues the story of the pocket proteins and the cell cycle.

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[ "Gene_or_gene_product" ]

cancer cells is a Cell, Ehrlich ascites is a Cell, L1210 murine leukemia cells is a Cell, tumor cells is a Cell, Ehrlich cells is a Cell, cell membrane is a Cellular_component

PMID-8272146_task0

Sentence: Effect of 1-alkylpyrrolidine N-oxides on energy metabolism of cancer cells. The main purpose of the present investigation was to study the effect of a homologous series of 1-alkylpyrrolidine N-oxides on ATP-producing processes in Ehrlich ascites and L1210 murine leukemia cells. The effect on aerobic glucose consumption, lactic acid formation, content of total (T-SH) and non-protein thiol groups (NP-SH), endogenous respiration and the level of ATP in tumor cells incubated in vitro was investigated. 1-Tetradecylpyrrolidine N-oxide (TPNO), one of the most active compounds, immediately after addition to the suspension of Ehrlich cells in an ice bath, decreased the level of ATP to the same extent over the whole concentration range. After 2 h incubation at 37 degrees C the drop in the ATP level was lower. The decrease in ATP level might be explained through the interaction of the amine oxide with the cell membrane integrity. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Cellular_component, Cell

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Effect of 1-alkylpyrrolidine N-oxides on energy metabolism of cancer cells. The main purpose of the present investigation was to study the effect of a homologous series of 1-alkylpyrrolidine N-oxides on ATP-producing processes in Ehrlich ascites and L1210 murine leukemia cells. The effect on aerobic glucose consumption, lactic acid formation, content of total (T-SH) and non-protein thiol groups (NP-SH), endogenous respiration and the level of ATP in tumor cells incubated in vitro was investigated. 1-Tetradecylpyrrolidine N-oxide (TPNO), one of the most active compounds, immediately after addition to the suspension of Ehrlich cells in an ice bath, decreased the level of ATP to the same extent over the whole concentration range. After 2 h incubation at 37 degrees C the drop in the ATP level was lower. The decrease in ATP level might be explained through the interaction of the amine oxide with the cell membrane integrity.

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[ "Cell", "Cellular_component" ]

cancer cells is a Cell, Ehrlich ascites is a Cell, L1210 murine leukemia cells is a Cell, tumor cells is a Cell, Ehrlich cells is a Cell, cell membrane is a Cellular_component

PMID-8272146_task1

Sentence: Effect of 1-alkylpyrrolidine N-oxides on energy metabolism of cancer cells. The main purpose of the present investigation was to study the effect of a homologous series of 1-alkylpyrrolidine N-oxides on ATP-producing processes in Ehrlich ascites and L1210 murine leukemia cells. The effect on aerobic glucose consumption, lactic acid formation, content of total (T-SH) and non-protein thiol groups (NP-SH), endogenous respiration and the level of ATP in tumor cells incubated in vitro was investigated. 1-Tetradecylpyrrolidine N-oxide (TPNO), one of the most active compounds, immediately after addition to the suspension of Ehrlich cells in an ice bath, decreased the level of ATP to the same extent over the whole concentration range. After 2 h incubation at 37 degrees C the drop in the ATP level was lower. The decrease in ATP level might be explained through the interaction of the amine oxide with the cell membrane integrity. Instructions: please typing these entity words according to sentence: cancer cells, Ehrlich ascites, L1210 murine leukemia cells, tumor cells, Ehrlich cells, cell membrane Options: Cellular_component, Cell

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Effect of 1-alkylpyrrolidine N-oxides on energy metabolism of cancer cells. The main purpose of the present investigation was to study the effect of a homologous series of 1-alkylpyrrolidine N-oxides on ATP-producing processes in Ehrlich ascites and L1210 murine leukemia cells. The effect on aerobic glucose consumption, lactic acid formation, content of total (T-SH) and non-protein thiol groups (NP-SH), endogenous respiration and the level of ATP in tumor cells incubated in vitro was investigated. 1-Tetradecylpyrrolidine N-oxide (TPNO), one of the most active compounds, immediately after addition to the suspension of Ehrlich cells in an ice bath, decreased the level of ATP to the same extent over the whole concentration range. After 2 h incubation at 37 degrees C the drop in the ATP level was lower. The decrease in ATP level might be explained through the interaction of the amine oxide with the cell membrane integrity.

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[ "Cell", "Cellular_component" ]

cancer cells, Ehrlich ascites, L1210 murine leukemia cells, tumor cells, Ehrlich cells, cell membrane

PMID-8272146_task2

Sentence: Effect of 1-alkylpyrrolidine N-oxides on energy metabolism of cancer cells. The main purpose of the present investigation was to study the effect of a homologous series of 1-alkylpyrrolidine N-oxides on ATP-producing processes in Ehrlich ascites and L1210 murine leukemia cells. The effect on aerobic glucose consumption, lactic acid formation, content of total (T-SH) and non-protein thiol groups (NP-SH), endogenous respiration and the level of ATP in tumor cells incubated in vitro was investigated. 1-Tetradecylpyrrolidine N-oxide (TPNO), one of the most active compounds, immediately after addition to the suspension of Ehrlich cells in an ice bath, decreased the level of ATP to the same extent over the whole concentration range. After 2 h incubation at 37 degrees C the drop in the ATP level was lower. The decrease in ATP level might be explained through the interaction of the amine oxide with the cell membrane integrity. Instructions: please extract entity words from the input sentence

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Effect of 1-alkylpyrrolidine N-oxides on energy metabolism of cancer cells. The main purpose of the present investigation was to study the effect of a homologous series of 1-alkylpyrrolidine N-oxides on ATP-producing processes in Ehrlich ascites and L1210 murine leukemia cells. The effect on aerobic glucose consumption, lactic acid formation, content of total (T-SH) and non-protein thiol groups (NP-SH), endogenous respiration and the level of ATP in tumor cells incubated in vitro was investigated. 1-Tetradecylpyrrolidine N-oxide (TPNO), one of the most active compounds, immediately after addition to the suspension of Ehrlich cells in an ice bath, decreased the level of ATP to the same extent over the whole concentration range. After 2 h incubation at 37 degrees C the drop in the ATP level was lower. The decrease in ATP level might be explained through the interaction of the amine oxide with the cell membrane integrity.

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[ "Cell", "Cellular_component" ]

Infektionen is an umlsterm, zerebrale Ischaemien is an umlsterm, Infektionen is an umlsterm, Risiko is an umlsterm, Infarkte is an umlsterm, Arteriosklerose is an umlsterm, Infektionen is an umlsterm, Patienten is an umlsterm, geschlechtsentsprechende is an umlsterm, Patienten is an umlsterm, Zahnstatus is an umlsterm, Karies is an umlsterm, Parodontitis is an umlsterm, Zaehne is an umlsterm, Patienten is an umlsterm, zerebralen Ischaemie is an umlsterm, Zahnstatus is an umlsterm, Zahnstatus is an umlsterm, Ischaemie is an umlsterm, Risikofaktoren is an umlsterm, Zahngesundheit is an umlsterm, Infektionen is an umlsterm, Risiko is an umlsterm, Ischaemien is an umlsterm, Infektionen is an umlsterm, Rolle is an umlsterm, Praeventivmedizin is an umlsterm

MundKieferGesichtschirurgie.80020316.ger.abstr_task0

Sentence: Fruehere Studien haben gezeigt , dass akute Infektionen , insbesondere der Atemwege , einen wichtigen Risikofaktor fuer zerebrale Ischaemien darstellen . Weiterhin wissen wir , dass chronische odontogene Infektionen ein Risiko fuer myokardiale Infarkte und Arteriosklerose sein koennen . Der Zusammenhang zwischen zerebralen Insulten und dentalen Infektionen wurde jedoch bislang kaum untersucht . Daher fuehrten wir eine Fall-Kontroll-Studie unter Anwendung eines standardisierten Erhebungsbogens und Untersuchungsprotokolls durch . Es wurden 66 Patienten mit einer akuten zerebralen Ischaemie/Insult sowie 60 weitere alters- und geschlechtsentsprechende neurologische Patienten als Kontrollgruppe untersucht . Der Zahnstatus wurde durch einen sog . Total-Dental-Index ( TDI ) , welcher in erster Linie Karies Parodontitis , , periapikale Laesionen , devitale und fehlende Zaehne beruecksichtigt , sowie durch einen Panoramaschichtindex ( PI ) erfasst . Speziell aeltere Patienten mit einer zerebralen Ischaemie wiesen tendenziell einen signifikant schlechteren Zahnstatus auf und besassen deutlich oefter Parodopathien und apikale Laesionen als Kontrollpersonen . Ein vorbestehender schlechter Zahnstatus war verknuepft mit einer zerebrovaskulaeren Ischaemie unabhaengig von anderen vaskulaeren Risikofaktoren und dem sozialen Status . Zusammenfassend gesagt , kann eine schlechte Zahngesundheit , v.a. aus chronischen odontogenen Infektionen resultierend , mit einem erhoehten Risiko fuer zerebrovaskulaere Ischaemien verbunden sein . Die Ergebnisse muessen nun in groesseren Folgestudien verifiziert werden . Da chronische dentale Infektionen weit verbreitete und ebenso leicht therapierbare Faktoren darstellen , wuerde ihre Identifikation als Risikofaktor fuer einen Insult eine ziemlich wichtige Rolle im Bereich der Praeventivmedizin spielen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Fruehere Studien haben gezeigt , dass akute Infektionen , insbesondere der Atemwege , einen wichtigen Risikofaktor fuer zerebrale Ischaemien darstellen . Weiterhin wissen wir , dass chronische odontogene Infektionen ein Risiko fuer myokardiale Infarkte und Arteriosklerose sein koennen . Der Zusammenhang zwischen zerebralen Insulten und dentalen Infektionen wurde jedoch bislang kaum untersucht . Daher fuehrten wir eine Fall-Kontroll-Studie unter Anwendung eines standardisierten Erhebungsbogens und Untersuchungsprotokolls durch . Es wurden 66 Patienten mit einer akuten zerebralen Ischaemie/Insult sowie 60 weitere alters- und geschlechtsentsprechende neurologische Patienten als Kontrollgruppe untersucht . Der Zahnstatus wurde durch einen sog . Total-Dental-Index ( TDI ) , welcher in erster Linie Karies Parodontitis , , periapikale Laesionen , devitale und fehlende Zaehne beruecksichtigt , sowie durch einen Panoramaschichtindex ( PI ) erfasst . Speziell aeltere Patienten mit einer zerebralen Ischaemie wiesen tendenziell einen signifikant schlechteren Zahnstatus auf und besassen deutlich oefter Parodopathien und apikale Laesionen als Kontrollpersonen . Ein vorbestehender schlechter Zahnstatus war verknuepft mit einer zerebrovaskulaeren Ischaemie unabhaengig von anderen vaskulaeren Risikofaktoren und dem sozialen Status . Zusammenfassend gesagt , kann eine schlechte Zahngesundheit , v.a. aus chronischen odontogenen Infektionen resultierend , mit einem erhoehten Risiko fuer zerebrovaskulaere Ischaemien verbunden sein . Die Ergebnisse muessen nun in groesseren Folgestudien verifiziert werden . Da chronische dentale Infektionen weit verbreitete und ebenso leicht therapierbare Faktoren darstellen , wuerde ihre Identifikation als Risikofaktor fuer einen Insult eine ziemlich wichtige Rolle im Bereich der Praeventivmedizin spielen .

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[ "umlsterm" ]

Infektionen is an umlsterm, zerebrale Ischaemien is an umlsterm, Infektionen is an umlsterm, Risiko is an umlsterm, Infarkte is an umlsterm, Arteriosklerose is an umlsterm, Infektionen is an umlsterm, Patienten is an umlsterm, geschlechtsentsprechende is an umlsterm, Patienten is an umlsterm, Zahnstatus is an umlsterm, Karies is an umlsterm, Parodontitis is an umlsterm, Zaehne is an umlsterm, Patienten is an umlsterm, zerebralen Ischaemie is an umlsterm, Zahnstatus is an umlsterm, Zahnstatus is an umlsterm, Ischaemie is an umlsterm, Risikofaktoren is an umlsterm, Zahngesundheit is an umlsterm, Infektionen is an umlsterm, Risiko is an umlsterm, Ischaemien is an umlsterm, Infektionen is an umlsterm, Rolle is an umlsterm, Praeventivmedizin is an umlsterm

MundKieferGesichtschirurgie.80020316.ger.abstr_task1

Sentence: Fruehere Studien haben gezeigt , dass akute Infektionen , insbesondere der Atemwege , einen wichtigen Risikofaktor fuer zerebrale Ischaemien darstellen . Weiterhin wissen wir , dass chronische odontogene Infektionen ein Risiko fuer myokardiale Infarkte und Arteriosklerose sein koennen . Der Zusammenhang zwischen zerebralen Insulten und dentalen Infektionen wurde jedoch bislang kaum untersucht . Daher fuehrten wir eine Fall-Kontroll-Studie unter Anwendung eines standardisierten Erhebungsbogens und Untersuchungsprotokolls durch . Es wurden 66 Patienten mit einer akuten zerebralen Ischaemie/Insult sowie 60 weitere alters- und geschlechtsentsprechende neurologische Patienten als Kontrollgruppe untersucht . Der Zahnstatus wurde durch einen sog . Total-Dental-Index ( TDI ) , welcher in erster Linie Karies Parodontitis , , periapikale Laesionen , devitale und fehlende Zaehne beruecksichtigt , sowie durch einen Panoramaschichtindex ( PI ) erfasst . Speziell aeltere Patienten mit einer zerebralen Ischaemie wiesen tendenziell einen signifikant schlechteren Zahnstatus auf und besassen deutlich oefter Parodopathien und apikale Laesionen als Kontrollpersonen . Ein vorbestehender schlechter Zahnstatus war verknuepft mit einer zerebrovaskulaeren Ischaemie unabhaengig von anderen vaskulaeren Risikofaktoren und dem sozialen Status . Zusammenfassend gesagt , kann eine schlechte Zahngesundheit , v.a. aus chronischen odontogenen Infektionen resultierend , mit einem erhoehten Risiko fuer zerebrovaskulaere Ischaemien verbunden sein . Die Ergebnisse muessen nun in groesseren Folgestudien verifiziert werden . Da chronische dentale Infektionen weit verbreitete und ebenso leicht therapierbare Faktoren darstellen , wuerde ihre Identifikation als Risikofaktor fuer einen Insult eine ziemlich wichtige Rolle im Bereich der Praeventivmedizin spielen . Instructions: please typing these entity words according to sentence: Infektionen, zerebrale Ischaemien, Infektionen, Risiko, Infarkte, Arteriosklerose, Infektionen, Patienten, geschlechtsentsprechende, Patienten, Zahnstatus, Karies, Parodontitis, Zaehne, Patienten, zerebralen Ischaemie, Zahnstatus, Zahnstatus, Ischaemie, Risikofaktoren, Zahngesundheit, Infektionen, Risiko, Ischaemien, Infektionen, Rolle, Praeventivmedizin Options: umlsterm

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Fruehere Studien haben gezeigt , dass akute Infektionen , insbesondere der Atemwege , einen wichtigen Risikofaktor fuer zerebrale Ischaemien darstellen . Weiterhin wissen wir , dass chronische odontogene Infektionen ein Risiko fuer myokardiale Infarkte und Arteriosklerose sein koennen . Der Zusammenhang zwischen zerebralen Insulten und dentalen Infektionen wurde jedoch bislang kaum untersucht . Daher fuehrten wir eine Fall-Kontroll-Studie unter Anwendung eines standardisierten Erhebungsbogens und Untersuchungsprotokolls durch . Es wurden 66 Patienten mit einer akuten zerebralen Ischaemie/Insult sowie 60 weitere alters- und geschlechtsentsprechende neurologische Patienten als Kontrollgruppe untersucht . Der Zahnstatus wurde durch einen sog . Total-Dental-Index ( TDI ) , welcher in erster Linie Karies Parodontitis , , periapikale Laesionen , devitale und fehlende Zaehne beruecksichtigt , sowie durch einen Panoramaschichtindex ( PI ) erfasst . Speziell aeltere Patienten mit einer zerebralen Ischaemie wiesen tendenziell einen signifikant schlechteren Zahnstatus auf und besassen deutlich oefter Parodopathien und apikale Laesionen als Kontrollpersonen . Ein vorbestehender schlechter Zahnstatus war verknuepft mit einer zerebrovaskulaeren Ischaemie unabhaengig von anderen vaskulaeren Risikofaktoren und dem sozialen Status . Zusammenfassend gesagt , kann eine schlechte Zahngesundheit , v.a. aus chronischen odontogenen Infektionen resultierend , mit einem erhoehten Risiko fuer zerebrovaskulaere Ischaemien verbunden sein . Die Ergebnisse muessen nun in groesseren Folgestudien verifiziert werden . Da chronische dentale Infektionen weit verbreitete und ebenso leicht therapierbare Faktoren darstellen , wuerde ihre Identifikation als Risikofaktor fuer einen Insult eine ziemlich wichtige Rolle im Bereich der Praeventivmedizin spielen .

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[ "umlsterm" ]

Infektionen, zerebrale Ischaemien, Infektionen, Risiko, Infarkte, Arteriosklerose, Infektionen, Patienten, geschlechtsentsprechende, Patienten, Zahnstatus, Karies, Parodontitis, Zaehne, Patienten, zerebralen Ischaemie, Zahnstatus, Zahnstatus, Ischaemie, Risikofaktoren, Zahngesundheit, Infektionen, Risiko, Ischaemien, Infektionen, Rolle, Praeventivmedizin

MundKieferGesichtschirurgie.80020316.ger.abstr_task2

Sentence: Fruehere Studien haben gezeigt , dass akute Infektionen , insbesondere der Atemwege , einen wichtigen Risikofaktor fuer zerebrale Ischaemien darstellen . Weiterhin wissen wir , dass chronische odontogene Infektionen ein Risiko fuer myokardiale Infarkte und Arteriosklerose sein koennen . Der Zusammenhang zwischen zerebralen Insulten und dentalen Infektionen wurde jedoch bislang kaum untersucht . Daher fuehrten wir eine Fall-Kontroll-Studie unter Anwendung eines standardisierten Erhebungsbogens und Untersuchungsprotokolls durch . Es wurden 66 Patienten mit einer akuten zerebralen Ischaemie/Insult sowie 60 weitere alters- und geschlechtsentsprechende neurologische Patienten als Kontrollgruppe untersucht . Der Zahnstatus wurde durch einen sog . Total-Dental-Index ( TDI ) , welcher in erster Linie Karies Parodontitis , , periapikale Laesionen , devitale und fehlende Zaehne beruecksichtigt , sowie durch einen Panoramaschichtindex ( PI ) erfasst . Speziell aeltere Patienten mit einer zerebralen Ischaemie wiesen tendenziell einen signifikant schlechteren Zahnstatus auf und besassen deutlich oefter Parodopathien und apikale Laesionen als Kontrollpersonen . Ein vorbestehender schlechter Zahnstatus war verknuepft mit einer zerebrovaskulaeren Ischaemie unabhaengig von anderen vaskulaeren Risikofaktoren und dem sozialen Status . Zusammenfassend gesagt , kann eine schlechte Zahngesundheit , v.a. aus chronischen odontogenen Infektionen resultierend , mit einem erhoehten Risiko fuer zerebrovaskulaere Ischaemien verbunden sein . Die Ergebnisse muessen nun in groesseren Folgestudien verifiziert werden . Da chronische dentale Infektionen weit verbreitete und ebenso leicht therapierbare Faktoren darstellen , wuerde ihre Identifikation als Risikofaktor fuer einen Insult eine ziemlich wichtige Rolle im Bereich der Praeventivmedizin spielen . Instructions: please extract entity words from the input sentence

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Fruehere Studien haben gezeigt , dass akute Infektionen , insbesondere der Atemwege , einen wichtigen Risikofaktor fuer zerebrale Ischaemien darstellen . Weiterhin wissen wir , dass chronische odontogene Infektionen ein Risiko fuer myokardiale Infarkte und Arteriosklerose sein koennen . Der Zusammenhang zwischen zerebralen Insulten und dentalen Infektionen wurde jedoch bislang kaum untersucht . Daher fuehrten wir eine Fall-Kontroll-Studie unter Anwendung eines standardisierten Erhebungsbogens und Untersuchungsprotokolls durch . Es wurden 66 Patienten mit einer akuten zerebralen Ischaemie/Insult sowie 60 weitere alters- und geschlechtsentsprechende neurologische Patienten als Kontrollgruppe untersucht . Der Zahnstatus wurde durch einen sog . Total-Dental-Index ( TDI ) , welcher in erster Linie Karies Parodontitis , , periapikale Laesionen , devitale und fehlende Zaehne beruecksichtigt , sowie durch einen Panoramaschichtindex ( PI ) erfasst . Speziell aeltere Patienten mit einer zerebralen Ischaemie wiesen tendenziell einen signifikant schlechteren Zahnstatus auf und besassen deutlich oefter Parodopathien und apikale Laesionen als Kontrollpersonen . Ein vorbestehender schlechter Zahnstatus war verknuepft mit einer zerebrovaskulaeren Ischaemie unabhaengig von anderen vaskulaeren Risikofaktoren und dem sozialen Status . Zusammenfassend gesagt , kann eine schlechte Zahngesundheit , v.a. aus chronischen odontogenen Infektionen resultierend , mit einem erhoehten Risiko fuer zerebrovaskulaere Ischaemien verbunden sein . Die Ergebnisse muessen nun in groesseren Folgestudien verifiziert werden . Da chronische dentale Infektionen weit verbreitete und ebenso leicht therapierbare Faktoren darstellen , wuerde ihre Identifikation als Risikofaktor fuer einen Insult eine ziemlich wichtige Rolle im Bereich der Praeventivmedizin spielen .

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[ "umlsterm" ]

body composition is an umlsterm, thirst is an umlsterm, perception is an umlsterm, function is an umlsterm, regulatory is an umlsterm, maintenance is an umlsterm, water is an umlsterm, sodium is an umlsterm, balance is an umlsterm, diseases is an umlsterm, drugs is an umlsterm, elderly is an umlsterm, water is an umlsterm, sodium is an umlsterm, symptoms is an umlsterm, morbidity is an umlsterm, mortality is an umlsterm, disorders is an umlsterm, dehydration is an umlsterm, hypernatremia is an umlsterm, hyponatremia is an umlsterm, frequency is an umlsterm, urinary incontinence is an umlsterm, elderly is an umlsterm, person is an umlsterm, risk is an umlsterm, water is an umlsterm, sodium is an umlsterm, balance is an umlsterm

ZfuerGerontologie+Geriatrie.9032s020.eng.abstr_task0

Sentence: Normal aging is associated with changes in body composition , thirst perception , renal function , and the hormonal regulatory systems involved in the maintenance of water and sodium balance . The presence of many diseases and drugs common in the elderly can interact with the impaired homeostatic systems to result in clinically significant disturbances of water and sodium with accompanying symptoms , morbidity , and mortality . These disorders , which include dehydration , hypernatremia , hyponatremia , urinary frequency , and urinary incontinence can either be prevented or promptly recognized and appropriately treated by understanding the physiological changes and clinical circumstances which put the elderly person at increased risk for deranged water and sodium balance . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O" ]

Normal aging is associated with changes in body composition , thirst perception , renal function , and the hormonal regulatory systems involved in the maintenance of water and sodium balance . The presence of many diseases and drugs common in the elderly can interact with the impaired homeostatic systems to result in clinically significant disturbances of water and sodium with accompanying symptoms , morbidity , and mortality . These disorders , which include dehydration , hypernatremia , hyponatremia , urinary frequency , and urinary incontinence can either be prevented or promptly recognized and appropriately treated by understanding the physiological changes and clinical circumstances which put the elderly person at increased risk for deranged water and sodium balance .

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[ "umlsterm" ]

body composition is an umlsterm, thirst is an umlsterm, perception is an umlsterm, function is an umlsterm, regulatory is an umlsterm, maintenance is an umlsterm, water is an umlsterm, sodium is an umlsterm, balance is an umlsterm, diseases is an umlsterm, drugs is an umlsterm, elderly is an umlsterm, water is an umlsterm, sodium is an umlsterm, symptoms is an umlsterm, morbidity is an umlsterm, mortality is an umlsterm, disorders is an umlsterm, dehydration is an umlsterm, hypernatremia is an umlsterm, hyponatremia is an umlsterm, frequency is an umlsterm, urinary incontinence is an umlsterm, elderly is an umlsterm, person is an umlsterm, risk is an umlsterm, water is an umlsterm, sodium is an umlsterm, balance is an umlsterm

ZfuerGerontologie+Geriatrie.9032s020.eng.abstr_task1

Sentence: Normal aging is associated with changes in body composition , thirst perception , renal function , and the hormonal regulatory systems involved in the maintenance of water and sodium balance . The presence of many diseases and drugs common in the elderly can interact with the impaired homeostatic systems to result in clinically significant disturbances of water and sodium with accompanying symptoms , morbidity , and mortality . These disorders , which include dehydration , hypernatremia , hyponatremia , urinary frequency , and urinary incontinence can either be prevented or promptly recognized and appropriately treated by understanding the physiological changes and clinical circumstances which put the elderly person at increased risk for deranged water and sodium balance . Instructions: please typing these entity words according to sentence: body composition, thirst, perception, function, regulatory, maintenance, water, sodium, balance, diseases, drugs, elderly, water, sodium, symptoms, morbidity, mortality, disorders, dehydration, hypernatremia, hyponatremia, frequency, urinary incontinence, elderly, person, risk, water, sodium, balance Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O" ]

Normal aging is associated with changes in body composition , thirst perception , renal function , and the hormonal regulatory systems involved in the maintenance of water and sodium balance . The presence of many diseases and drugs common in the elderly can interact with the impaired homeostatic systems to result in clinically significant disturbances of water and sodium with accompanying symptoms , morbidity , and mortality . These disorders , which include dehydration , hypernatremia , hyponatremia , urinary frequency , and urinary incontinence can either be prevented or promptly recognized and appropriately treated by understanding the physiological changes and clinical circumstances which put the elderly person at increased risk for deranged water and sodium balance .

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[ "umlsterm" ]

body composition, thirst, perception, function, regulatory, maintenance, water, sodium, balance, diseases, drugs, elderly, water, sodium, symptoms, morbidity, mortality, disorders, dehydration, hypernatremia, hyponatremia, frequency, urinary incontinence, elderly, person, risk, water, sodium, balance

ZfuerGerontologie+Geriatrie.9032s020.eng.abstr_task2

Sentence: Normal aging is associated with changes in body composition , thirst perception , renal function , and the hormonal regulatory systems involved in the maintenance of water and sodium balance . The presence of many diseases and drugs common in the elderly can interact with the impaired homeostatic systems to result in clinically significant disturbances of water and sodium with accompanying symptoms , morbidity , and mortality . These disorders , which include dehydration , hypernatremia , hyponatremia , urinary frequency , and urinary incontinence can either be prevented or promptly recognized and appropriately treated by understanding the physiological changes and clinical circumstances which put the elderly person at increased risk for deranged water and sodium balance . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O" ]

Normal aging is associated with changes in body composition , thirst perception , renal function , and the hormonal regulatory systems involved in the maintenance of water and sodium balance . The presence of many diseases and drugs common in the elderly can interact with the impaired homeostatic systems to result in clinically significant disturbances of water and sodium with accompanying symptoms , morbidity , and mortality . These disorders , which include dehydration , hypernatremia , hyponatremia , urinary frequency , and urinary incontinence can either be prevented or promptly recognized and appropriately treated by understanding the physiological changes and clinical circumstances which put the elderly person at increased risk for deranged water and sodium balance .

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[ "umlsterm" ]

dTAFII110 is a protein, GST - IIAτ is a fusion-protein, GST - αβ is a fusion-protein

1.0alpha7.train.271_task0

Sentence: Interestingly, dTAFII110 also bound GST-IIAτ more abundantly than it bound to GST-αβ (Fig.4 C, lane 4). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: fusion-protein, protein

[ "O", "O", "B-protein", "O", "O", "B-fusion-protein", "I-fusion-protein", "I-fusion-protein", "O", "O", "O", "O", "O", "O", "B-fusion-protein", "I-fusion-protein", "I-fusion-protein", "O", "O", "O", "O", "O", "O", "O", "O" ]

Interestingly, dTAFII110 also bound GST-IIAτ more abundantly than it bound to GST-αβ (Fig.4 C, lane 4).

[ "Interestingly", ",", "dTAFII110", "also", "bound", "GST", "-", "IIAτ", "more", "abundantly", "than", "it", "bound", "to", "GST", "-", "αβ", "(", "Fig.4", "C", ",", "lane", "4", ")", "." ]

[ "protein", "fusion-protein", "experiment-tag" ]

dTAFII110 is a protein, GST - IIAτ is a fusion-protein, GST - αβ is a fusion-protein

1.0alpha7.train.271_task1

Sentence: Interestingly, dTAFII110 also bound GST-IIAτ more abundantly than it bound to GST-αβ (Fig.4 C, lane 4). Instructions: please typing these entity words according to sentence: dTAFII110, GST - IIAτ, GST - αβ Options: fusion-protein, protein

[ "O", "O", "B-protein", "O", "O", "B-fusion-protein", "I-fusion-protein", "I-fusion-protein", "O", "O", "O", "O", "O", "O", "B-fusion-protein", "I-fusion-protein", "I-fusion-protein", "O", "O", "O", "O", "O", "O", "O", "O" ]

Interestingly, dTAFII110 also bound GST-IIAτ more abundantly than it bound to GST-αβ (Fig.4 C, lane 4).

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[ "protein", "fusion-protein", "experiment-tag" ]

dTAFII110, GST - IIAτ, GST - αβ

1.0alpha7.train.271_task2

Sentence: Interestingly, dTAFII110 also bound GST-IIAτ more abundantly than it bound to GST-αβ (Fig.4 C, lane 4). Instructions: please extract entity words from the input sentence

[ "O", "O", "B-protein", "O", "O", "B-fusion-protein", "I-fusion-protein", "I-fusion-protein", "O", "O", "O", "O", "O", "O", "B-fusion-protein", "I-fusion-protein", "I-fusion-protein", "O", "O", "O", "O", "O", "O", "O", "O" ]

Interestingly, dTAFII110 also bound GST-IIAτ more abundantly than it bound to GST-αβ (Fig.4 C, lane 4).

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[ "protein", "fusion-protein", "experiment-tag" ]

Arbeit is an umlsterm, chronischen Polyarthritis is an umlsterm, Gelenkdestruktion is an umlsterm, Methode is an umlsterm, Europa is an umlsterm, Standardreferenzfilmen is an umlsterm, Gelenkoberflaeche is an umlsterm, gelenknahe is an umlsterm, Osteoporose is an umlsterm, Originalmethode is an umlsterm, Gelenkoberflaeche is an umlsterm, Gelenkoberflaeche is an umlsterm, Gelenkoberflaeche is an umlsterm, Gelenke is an umlsterm, Haende is an umlsterm, Standardreferenzfilmen is an umlsterm, Fingergrund- is an umlsterm, Fingermittel- is an umlsterm, Handgelenke is an umlsterm, Zehengrundgelenke is an umlsterm, Methode is an umlsterm, Haende is an umlsterm, Patienten is an umlsterm, chronischer Polyarthritis is an umlsterm, Patienten is an umlsterm, Varianzanalyse is an umlsterm, ANOVA is an umlsterm, Methode is an umlsterm, Methode is an umlsterm, Patienten is an umlsterm, Basistherapiestudie is an umlsterm, Roentgenaufnahmen is an umlsterm, Therapiebeginn is an umlsterm, Verzoegerung is an umlsterm, radiologischen is an umlsterm, Gold is an umlsterm, Methotrexat is an umlsterm, radiologischen is an umlsterm, chronischen Polyarthritis is an umlsterm, Methode is an umlsterm

ZfuerRheumatologie.70560127.ger.abstr_task0

Sentence: Ziel der Arbeit : Entwicklung und Evaluation einer Modifikation der Larsen-Methode zur quantitativen Beschreibung des roentgenologischen Verlaufs der chronischen Polyarthritis mit dem Ziel einer eindeutigen verbalen Definition der verschiedenen Stadien und einer besseren Korrelation der numerischen Skala mit dem Ausmass der Gelenkdestruktion . Beschreibung der Methode : Waehrend die in Europa haeufig verwendete Original-Larsen-Methode im wesentlichen auf dem Vergleich der Roentgenbilder mit Standardreferenzfilmen bei nur vager verbaler Definition beruht , werden in der Modifikation die verschiedenen Stadien auch verbal durch semiquantitative Angabe des Ausmasses der Destruktion der Gelenkoberflaeche definiert : das StadiumI ist durch Weichteilschwellung und ggf. gelenknahe Osteoporose bzw. auch Gelenkspaltverschmaelerung charakterisiert und bleibt damit gegenueber der Originalmethode unveraendert ; das Stadium II entspricht einer Destruktion der Gelenkoberflaeche bis zu 25% der gesamten Gelenkoberflaeche , im StadiumIII sind 26-50% , im Stadium IV 51-75% und im StadiumV ueber 75% der Gelenkoberflaeche destruiert . 32 Gelenke der Haende und Vorfuesse werden bewertet , so dass sich ein Gesamtscore von 0-160 ergibt . Bespiele fuer die verschiedenen Stadien im Sinne von Standardreferenzfilmen fuer die Fingergrund- , Fingermittel- und Handgelenke sowie die Zehengrundgelenke werden gezeigt . Evaluation der Methode : Standard-ap-Aufnahmen der Haende und Vorfuesse von 24 Patienten mit frueher erosiver chronischer Polyarthritis ( c.P. ) zum Zeitpunkt 0 ( T0) und nach 36 Monaten ( T1) wurden von zwei Untersuchern ( G.H. und R.R. ) bewertet . Der Unterschied der Bewertung zwischen den beiden Untersuchern ( Inter-Observer-Differenz ) wurde mit dem Unterschied zwischen den beiden Zeitpunkten ( T0 und T1) beim gleichen Patienten ( Intra-Patienten-Differenz ) mittels einer hierarchischen Varianzanalyse ( ANOVA ) verglichen . Dabei erwies sich die Intrapatientenvarianz ( von T0 nach T1) als 8 mal groesser als die Varianz zwischen den Untersuchern . Der mit der Methode gefundene Unterschied zwischen beiden Beobachtungszeitpunkten ist also real und nicht durch Unsicherheit bei der Bewertung bedingt . - Zusaetzlich wurde die Methode bei Patienten einer zweijaehrigen Basistherapiestudie mit Roentgenaufnahmen zu Therapiebeginn sowie nach 6 , 12 und 24 Monaten angewandt . Dabei konnte eine Verzoegerung der radiologischen Progression nach dem sechsten Monat durch parenterales Gold und Methotrexat demonstriert werden . Schlussfolgerung : Die Modifikation der Larsen-Methode erweist sich als zuverlaessiges Mass zur Beschreibung des radiologischen Verlaufs der chronischen Polyarthritis . Weitere Verbesserungsmoeglichkeiten der Methode werden diskutiert . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Ziel der Arbeit : Entwicklung und Evaluation einer Modifikation der Larsen-Methode zur quantitativen Beschreibung des roentgenologischen Verlaufs der chronischen Polyarthritis mit dem Ziel einer eindeutigen verbalen Definition der verschiedenen Stadien und einer besseren Korrelation der numerischen Skala mit dem Ausmass der Gelenkdestruktion . Beschreibung der Methode : Waehrend die in Europa haeufig verwendete Original-Larsen-Methode im wesentlichen auf dem Vergleich der Roentgenbilder mit Standardreferenzfilmen bei nur vager verbaler Definition beruht , werden in der Modifikation die verschiedenen Stadien auch verbal durch semiquantitative Angabe des Ausmasses der Destruktion der Gelenkoberflaeche definiert : das StadiumI ist durch Weichteilschwellung und ggf. gelenknahe Osteoporose bzw. auch Gelenkspaltverschmaelerung charakterisiert und bleibt damit gegenueber der Originalmethode unveraendert ; das Stadium II entspricht einer Destruktion der Gelenkoberflaeche bis zu 25% der gesamten Gelenkoberflaeche , im StadiumIII sind 26-50% , im Stadium IV 51-75% und im StadiumV ueber 75% der Gelenkoberflaeche destruiert . 32 Gelenke der Haende und Vorfuesse werden bewertet , so dass sich ein Gesamtscore von 0-160 ergibt . Bespiele fuer die verschiedenen Stadien im Sinne von Standardreferenzfilmen fuer die Fingergrund- , Fingermittel- und Handgelenke sowie die Zehengrundgelenke werden gezeigt . Evaluation der Methode : Standard-ap-Aufnahmen der Haende und Vorfuesse von 24 Patienten mit frueher erosiver chronischer Polyarthritis ( c.P. ) zum Zeitpunkt 0 ( T0) und nach 36 Monaten ( T1) wurden von zwei Untersuchern ( G.H. und R.R. ) bewertet . Der Unterschied der Bewertung zwischen den beiden Untersuchern ( Inter-Observer-Differenz ) wurde mit dem Unterschied zwischen den beiden Zeitpunkten ( T0 und T1) beim gleichen Patienten ( Intra-Patienten-Differenz ) mittels einer hierarchischen Varianzanalyse ( ANOVA ) verglichen . Dabei erwies sich die Intrapatientenvarianz ( von T0 nach T1) als 8 mal groesser als die Varianz zwischen den Untersuchern . Der mit der Methode gefundene Unterschied zwischen beiden Beobachtungszeitpunkten ist also real und nicht durch Unsicherheit bei der Bewertung bedingt . - Zusaetzlich wurde die Methode bei Patienten einer zweijaehrigen Basistherapiestudie mit Roentgenaufnahmen zu Therapiebeginn sowie nach 6 , 12 und 24 Monaten angewandt . Dabei konnte eine Verzoegerung der radiologischen Progression nach dem sechsten Monat durch parenterales Gold und Methotrexat demonstriert werden . Schlussfolgerung : Die Modifikation der Larsen-Methode erweist sich als zuverlaessiges Mass zur Beschreibung des radiologischen Verlaufs der chronischen Polyarthritis . Weitere Verbesserungsmoeglichkeiten der Methode werden diskutiert .

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[ "umlsterm" ]

Arbeit is an umlsterm, chronischen Polyarthritis is an umlsterm, Gelenkdestruktion is an umlsterm, Methode is an umlsterm, Europa is an umlsterm, Standardreferenzfilmen is an umlsterm, Gelenkoberflaeche is an umlsterm, gelenknahe is an umlsterm, Osteoporose is an umlsterm, Originalmethode is an umlsterm, Gelenkoberflaeche is an umlsterm, Gelenkoberflaeche is an umlsterm, Gelenkoberflaeche is an umlsterm, Gelenke is an umlsterm, Haende is an umlsterm, Standardreferenzfilmen is an umlsterm, Fingergrund- is an umlsterm, Fingermittel- is an umlsterm, Handgelenke is an umlsterm, Zehengrundgelenke is an umlsterm, Methode is an umlsterm, Haende is an umlsterm, Patienten is an umlsterm, chronischer Polyarthritis is an umlsterm, Patienten is an umlsterm, Varianzanalyse is an umlsterm, ANOVA is an umlsterm, Methode is an umlsterm, Methode is an umlsterm, Patienten is an umlsterm, Basistherapiestudie is an umlsterm, Roentgenaufnahmen is an umlsterm, Therapiebeginn is an umlsterm, Verzoegerung is an umlsterm, radiologischen is an umlsterm, Gold is an umlsterm, Methotrexat is an umlsterm, radiologischen is an umlsterm, chronischen Polyarthritis is an umlsterm, Methode is an umlsterm

ZfuerRheumatologie.70560127.ger.abstr_task1

Sentence: Ziel der Arbeit : Entwicklung und Evaluation einer Modifikation der Larsen-Methode zur quantitativen Beschreibung des roentgenologischen Verlaufs der chronischen Polyarthritis mit dem Ziel einer eindeutigen verbalen Definition der verschiedenen Stadien und einer besseren Korrelation der numerischen Skala mit dem Ausmass der Gelenkdestruktion . Beschreibung der Methode : Waehrend die in Europa haeufig verwendete Original-Larsen-Methode im wesentlichen auf dem Vergleich der Roentgenbilder mit Standardreferenzfilmen bei nur vager verbaler Definition beruht , werden in der Modifikation die verschiedenen Stadien auch verbal durch semiquantitative Angabe des Ausmasses der Destruktion der Gelenkoberflaeche definiert : das StadiumI ist durch Weichteilschwellung und ggf. gelenknahe Osteoporose bzw. auch Gelenkspaltverschmaelerung charakterisiert und bleibt damit gegenueber der Originalmethode unveraendert ; das Stadium II entspricht einer Destruktion der Gelenkoberflaeche bis zu 25% der gesamten Gelenkoberflaeche , im StadiumIII sind 26-50% , im Stadium IV 51-75% und im StadiumV ueber 75% der Gelenkoberflaeche destruiert . 32 Gelenke der Haende und Vorfuesse werden bewertet , so dass sich ein Gesamtscore von 0-160 ergibt . Bespiele fuer die verschiedenen Stadien im Sinne von Standardreferenzfilmen fuer die Fingergrund- , Fingermittel- und Handgelenke sowie die Zehengrundgelenke werden gezeigt . Evaluation der Methode : Standard-ap-Aufnahmen der Haende und Vorfuesse von 24 Patienten mit frueher erosiver chronischer Polyarthritis ( c.P. ) zum Zeitpunkt 0 ( T0) und nach 36 Monaten ( T1) wurden von zwei Untersuchern ( G.H. und R.R. ) bewertet . Der Unterschied der Bewertung zwischen den beiden Untersuchern ( Inter-Observer-Differenz ) wurde mit dem Unterschied zwischen den beiden Zeitpunkten ( T0 und T1) beim gleichen Patienten ( Intra-Patienten-Differenz ) mittels einer hierarchischen Varianzanalyse ( ANOVA ) verglichen . Dabei erwies sich die Intrapatientenvarianz ( von T0 nach T1) als 8 mal groesser als die Varianz zwischen den Untersuchern . Der mit der Methode gefundene Unterschied zwischen beiden Beobachtungszeitpunkten ist also real und nicht durch Unsicherheit bei der Bewertung bedingt . - Zusaetzlich wurde die Methode bei Patienten einer zweijaehrigen Basistherapiestudie mit Roentgenaufnahmen zu Therapiebeginn sowie nach 6 , 12 und 24 Monaten angewandt . Dabei konnte eine Verzoegerung der radiologischen Progression nach dem sechsten Monat durch parenterales Gold und Methotrexat demonstriert werden . Schlussfolgerung : Die Modifikation der Larsen-Methode erweist sich als zuverlaessiges Mass zur Beschreibung des radiologischen Verlaufs der chronischen Polyarthritis . Weitere Verbesserungsmoeglichkeiten der Methode werden diskutiert . Instructions: please typing these entity words according to sentence: Arbeit, chronischen Polyarthritis, Gelenkdestruktion, Methode, Europa, Standardreferenzfilmen, Gelenkoberflaeche, gelenknahe, Osteoporose, Originalmethode, Gelenkoberflaeche, Gelenkoberflaeche, Gelenkoberflaeche, Gelenke, Haende, Standardreferenzfilmen, Fingergrund-, Fingermittel-, Handgelenke, Zehengrundgelenke, Methode, Haende, Patienten, chronischer Polyarthritis, Patienten, Varianzanalyse, ANOVA, Methode, Methode, Patienten, Basistherapiestudie, Roentgenaufnahmen, Therapiebeginn, Verzoegerung, radiologischen, Gold, Methotrexat, radiologischen, chronischen Polyarthritis, Methode Options: umlsterm

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Ziel der Arbeit : Entwicklung und Evaluation einer Modifikation der Larsen-Methode zur quantitativen Beschreibung des roentgenologischen Verlaufs der chronischen Polyarthritis mit dem Ziel einer eindeutigen verbalen Definition der verschiedenen Stadien und einer besseren Korrelation der numerischen Skala mit dem Ausmass der Gelenkdestruktion . Beschreibung der Methode : Waehrend die in Europa haeufig verwendete Original-Larsen-Methode im wesentlichen auf dem Vergleich der Roentgenbilder mit Standardreferenzfilmen bei nur vager verbaler Definition beruht , werden in der Modifikation die verschiedenen Stadien auch verbal durch semiquantitative Angabe des Ausmasses der Destruktion der Gelenkoberflaeche definiert : das StadiumI ist durch Weichteilschwellung und ggf. gelenknahe Osteoporose bzw. auch Gelenkspaltverschmaelerung charakterisiert und bleibt damit gegenueber der Originalmethode unveraendert ; das Stadium II entspricht einer Destruktion der Gelenkoberflaeche bis zu 25% der gesamten Gelenkoberflaeche , im StadiumIII sind 26-50% , im Stadium IV 51-75% und im StadiumV ueber 75% der Gelenkoberflaeche destruiert . 32 Gelenke der Haende und Vorfuesse werden bewertet , so dass sich ein Gesamtscore von 0-160 ergibt . Bespiele fuer die verschiedenen Stadien im Sinne von Standardreferenzfilmen fuer die Fingergrund- , Fingermittel- und Handgelenke sowie die Zehengrundgelenke werden gezeigt . Evaluation der Methode : Standard-ap-Aufnahmen der Haende und Vorfuesse von 24 Patienten mit frueher erosiver chronischer Polyarthritis ( c.P. ) zum Zeitpunkt 0 ( T0) und nach 36 Monaten ( T1) wurden von zwei Untersuchern ( G.H. und R.R. ) bewertet . Der Unterschied der Bewertung zwischen den beiden Untersuchern ( Inter-Observer-Differenz ) wurde mit dem Unterschied zwischen den beiden Zeitpunkten ( T0 und T1) beim gleichen Patienten ( Intra-Patienten-Differenz ) mittels einer hierarchischen Varianzanalyse ( ANOVA ) verglichen . Dabei erwies sich die Intrapatientenvarianz ( von T0 nach T1) als 8 mal groesser als die Varianz zwischen den Untersuchern . Der mit der Methode gefundene Unterschied zwischen beiden Beobachtungszeitpunkten ist also real und nicht durch Unsicherheit bei der Bewertung bedingt . - Zusaetzlich wurde die Methode bei Patienten einer zweijaehrigen Basistherapiestudie mit Roentgenaufnahmen zu Therapiebeginn sowie nach 6 , 12 und 24 Monaten angewandt . Dabei konnte eine Verzoegerung der radiologischen Progression nach dem sechsten Monat durch parenterales Gold und Methotrexat demonstriert werden . Schlussfolgerung : Die Modifikation der Larsen-Methode erweist sich als zuverlaessiges Mass zur Beschreibung des radiologischen Verlaufs der chronischen Polyarthritis . Weitere Verbesserungsmoeglichkeiten der Methode werden diskutiert .

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[ "umlsterm" ]

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ZfuerRheumatologie.70560127.ger.abstr_task2

Sentence: Ziel der Arbeit : Entwicklung und Evaluation einer Modifikation der Larsen-Methode zur quantitativen Beschreibung des roentgenologischen Verlaufs der chronischen Polyarthritis mit dem Ziel einer eindeutigen verbalen Definition der verschiedenen Stadien und einer besseren Korrelation der numerischen Skala mit dem Ausmass der Gelenkdestruktion . Beschreibung der Methode : Waehrend die in Europa haeufig verwendete Original-Larsen-Methode im wesentlichen auf dem Vergleich der Roentgenbilder mit Standardreferenzfilmen bei nur vager verbaler Definition beruht , werden in der Modifikation die verschiedenen Stadien auch verbal durch semiquantitative Angabe des Ausmasses der Destruktion der Gelenkoberflaeche definiert : das StadiumI ist durch Weichteilschwellung und ggf. gelenknahe Osteoporose bzw. auch Gelenkspaltverschmaelerung charakterisiert und bleibt damit gegenueber der Originalmethode unveraendert ; das Stadium II entspricht einer Destruktion der Gelenkoberflaeche bis zu 25% der gesamten Gelenkoberflaeche , im StadiumIII sind 26-50% , im Stadium IV 51-75% und im StadiumV ueber 75% der Gelenkoberflaeche destruiert . 32 Gelenke der Haende und Vorfuesse werden bewertet , so dass sich ein Gesamtscore von 0-160 ergibt . Bespiele fuer die verschiedenen Stadien im Sinne von Standardreferenzfilmen fuer die Fingergrund- , Fingermittel- und Handgelenke sowie die Zehengrundgelenke werden gezeigt . Evaluation der Methode : Standard-ap-Aufnahmen der Haende und Vorfuesse von 24 Patienten mit frueher erosiver chronischer Polyarthritis ( c.P. ) zum Zeitpunkt 0 ( T0) und nach 36 Monaten ( T1) wurden von zwei Untersuchern ( G.H. und R.R. ) bewertet . Der Unterschied der Bewertung zwischen den beiden Untersuchern ( Inter-Observer-Differenz ) wurde mit dem Unterschied zwischen den beiden Zeitpunkten ( T0 und T1) beim gleichen Patienten ( Intra-Patienten-Differenz ) mittels einer hierarchischen Varianzanalyse ( ANOVA ) verglichen . Dabei erwies sich die Intrapatientenvarianz ( von T0 nach T1) als 8 mal groesser als die Varianz zwischen den Untersuchern . Der mit der Methode gefundene Unterschied zwischen beiden Beobachtungszeitpunkten ist also real und nicht durch Unsicherheit bei der Bewertung bedingt . - Zusaetzlich wurde die Methode bei Patienten einer zweijaehrigen Basistherapiestudie mit Roentgenaufnahmen zu Therapiebeginn sowie nach 6 , 12 und 24 Monaten angewandt . Dabei konnte eine Verzoegerung der radiologischen Progression nach dem sechsten Monat durch parenterales Gold und Methotrexat demonstriert werden . Schlussfolgerung : Die Modifikation der Larsen-Methode erweist sich als zuverlaessiges Mass zur Beschreibung des radiologischen Verlaufs der chronischen Polyarthritis . Weitere Verbesserungsmoeglichkeiten der Methode werden diskutiert . Instructions: please extract entity words from the input sentence

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Ziel der Arbeit : Entwicklung und Evaluation einer Modifikation der Larsen-Methode zur quantitativen Beschreibung des roentgenologischen Verlaufs der chronischen Polyarthritis mit dem Ziel einer eindeutigen verbalen Definition der verschiedenen Stadien und einer besseren Korrelation der numerischen Skala mit dem Ausmass der Gelenkdestruktion . Beschreibung der Methode : Waehrend die in Europa haeufig verwendete Original-Larsen-Methode im wesentlichen auf dem Vergleich der Roentgenbilder mit Standardreferenzfilmen bei nur vager verbaler Definition beruht , werden in der Modifikation die verschiedenen Stadien auch verbal durch semiquantitative Angabe des Ausmasses der Destruktion der Gelenkoberflaeche definiert : das StadiumI ist durch Weichteilschwellung und ggf. gelenknahe Osteoporose bzw. auch Gelenkspaltverschmaelerung charakterisiert und bleibt damit gegenueber der Originalmethode unveraendert ; das Stadium II entspricht einer Destruktion der Gelenkoberflaeche bis zu 25% der gesamten Gelenkoberflaeche , im StadiumIII sind 26-50% , im Stadium IV 51-75% und im StadiumV ueber 75% der Gelenkoberflaeche destruiert . 32 Gelenke der Haende und Vorfuesse werden bewertet , so dass sich ein Gesamtscore von 0-160 ergibt . Bespiele fuer die verschiedenen Stadien im Sinne von Standardreferenzfilmen fuer die Fingergrund- , Fingermittel- und Handgelenke sowie die Zehengrundgelenke werden gezeigt . Evaluation der Methode : Standard-ap-Aufnahmen der Haende und Vorfuesse von 24 Patienten mit frueher erosiver chronischer Polyarthritis ( c.P. ) zum Zeitpunkt 0 ( T0) und nach 36 Monaten ( T1) wurden von zwei Untersuchern ( G.H. und R.R. ) bewertet . Der Unterschied der Bewertung zwischen den beiden Untersuchern ( Inter-Observer-Differenz ) wurde mit dem Unterschied zwischen den beiden Zeitpunkten ( T0 und T1) beim gleichen Patienten ( Intra-Patienten-Differenz ) mittels einer hierarchischen Varianzanalyse ( ANOVA ) verglichen . Dabei erwies sich die Intrapatientenvarianz ( von T0 nach T1) als 8 mal groesser als die Varianz zwischen den Untersuchern . Der mit der Methode gefundene Unterschied zwischen beiden Beobachtungszeitpunkten ist also real und nicht durch Unsicherheit bei der Bewertung bedingt . - Zusaetzlich wurde die Methode bei Patienten einer zweijaehrigen Basistherapiestudie mit Roentgenaufnahmen zu Therapiebeginn sowie nach 6 , 12 und 24 Monaten angewandt . Dabei konnte eine Verzoegerung der radiologischen Progression nach dem sechsten Monat durch parenterales Gold und Methotrexat demonstriert werden . Schlussfolgerung : Die Modifikation der Larsen-Methode erweist sich als zuverlaessiges Mass zur Beschreibung des radiologischen Verlaufs der chronischen Polyarthritis . Weitere Verbesserungsmoeglichkeiten der Methode werden diskutiert .

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MundKieferGesichtschirurgie.80020026.eng.abstr_task0

Sentence: The median palatine suture has long been regarded as having the greatest resistance to dilatation of the maxilla . In 1984 Glassman [ 3 ] presented a conservative-surgical method of division of the palatineal suture in which only the lateral and anterior support of the maxilla is debilitated surgically . An orthodontic apparatus cemented in place preoperatively is already used intraoperatively for dilatation of the maxilla . In the period from 1991 to 1997 , 16 patients with a leptomaxilla and various dysnathic findings have been operated on at our clinic by the method described by Glassman [ 3 ] . Sometimes the maxilla was dilated intraoperatively using the apparatus cemented in place by the method of Derichsweiler and dilatation was continued postoperatively until the described result was achieved . After successful dilatation of the maxilla and a stabilizing phase , a mono- or bimaxillary operation was performed . The use of this method led to the desired result in 15 patients . Dilatation of the maxilla was objectivized by determining the pre- and postoperative width of the anterior and posterior dental arch using models and X-ray of the occlusal overlay of the maxilla . In one patient who was operated on at the age of 38 years , a fracture of the alveolar process of the maxilla occurred unilaterally due to the completed ossification of the median palatine suture . The method of surgically aided dilatation of the maxilla at the level of Le Fort I plane is suitable for patients up to the age of 30. In older patients , the median palatine suture should be transsected as well . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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The median palatine suture has long been regarded as having the greatest resistance to dilatation of the maxilla . In 1984 Glassman [ 3 ] presented a conservative-surgical method of division of the palatineal suture in which only the lateral and anterior support of the maxilla is debilitated surgically . An orthodontic apparatus cemented in place preoperatively is already used intraoperatively for dilatation of the maxilla . In the period from 1991 to 1997 , 16 patients with a leptomaxilla and various dysnathic findings have been operated on at our clinic by the method described by Glassman [ 3 ] . Sometimes the maxilla was dilated intraoperatively using the apparatus cemented in place by the method of Derichsweiler and dilatation was continued postoperatively until the described result was achieved . After successful dilatation of the maxilla and a stabilizing phase , a mono- or bimaxillary operation was performed . The use of this method led to the desired result in 15 patients . Dilatation of the maxilla was objectivized by determining the pre- and postoperative width of the anterior and posterior dental arch using models and X-ray of the occlusal overlay of the maxilla . In one patient who was operated on at the age of 38 years , a fracture of the alveolar process of the maxilla occurred unilaterally due to the completed ossification of the median palatine suture . The method of surgically aided dilatation of the maxilla at the level of Le Fort I plane is suitable for patients up to the age of 30. In older patients , the median palatine suture should be transsected as well .

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[ "umlsterm" ]

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MundKieferGesichtschirurgie.80020026.eng.abstr_task1

Sentence: The median palatine suture has long been regarded as having the greatest resistance to dilatation of the maxilla . In 1984 Glassman [ 3 ] presented a conservative-surgical method of division of the palatineal suture in which only the lateral and anterior support of the maxilla is debilitated surgically . An orthodontic apparatus cemented in place preoperatively is already used intraoperatively for dilatation of the maxilla . In the period from 1991 to 1997 , 16 patients with a leptomaxilla and various dysnathic findings have been operated on at our clinic by the method described by Glassman [ 3 ] . Sometimes the maxilla was dilated intraoperatively using the apparatus cemented in place by the method of Derichsweiler and dilatation was continued postoperatively until the described result was achieved . After successful dilatation of the maxilla and a stabilizing phase , a mono- or bimaxillary operation was performed . The use of this method led to the desired result in 15 patients . Dilatation of the maxilla was objectivized by determining the pre- and postoperative width of the anterior and posterior dental arch using models and X-ray of the occlusal overlay of the maxilla . In one patient who was operated on at the age of 38 years , a fracture of the alveolar process of the maxilla occurred unilaterally due to the completed ossification of the median palatine suture . The method of surgically aided dilatation of the maxilla at the level of Le Fort I plane is suitable for patients up to the age of 30. In older patients , the median palatine suture should be transsected as well . Instructions: please typing these entity words according to sentence: dilatation, maxilla, conservative - surgical, method, anterior, maxilla, apparatus, dilatation, maxilla, period, patients, findings, method, maxilla, apparatus, method, dilatation, dilatation, maxilla, mono-, operation, use, method, patients, Dilatation, maxilla, postoperative, anterior, posterior, dental arch, X - ray, maxilla, patient, age, fracture, alveolar process, maxilla, method, dilatation, maxilla, patients, age, older, patients Options: umlsterm

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The median palatine suture has long been regarded as having the greatest resistance to dilatation of the maxilla . In 1984 Glassman [ 3 ] presented a conservative-surgical method of division of the palatineal suture in which only the lateral and anterior support of the maxilla is debilitated surgically . An orthodontic apparatus cemented in place preoperatively is already used intraoperatively for dilatation of the maxilla . In the period from 1991 to 1997 , 16 patients with a leptomaxilla and various dysnathic findings have been operated on at our clinic by the method described by Glassman [ 3 ] . Sometimes the maxilla was dilated intraoperatively using the apparatus cemented in place by the method of Derichsweiler and dilatation was continued postoperatively until the described result was achieved . After successful dilatation of the maxilla and a stabilizing phase , a mono- or bimaxillary operation was performed . The use of this method led to the desired result in 15 patients . Dilatation of the maxilla was objectivized by determining the pre- and postoperative width of the anterior and posterior dental arch using models and X-ray of the occlusal overlay of the maxilla . In one patient who was operated on at the age of 38 years , a fracture of the alveolar process of the maxilla occurred unilaterally due to the completed ossification of the median palatine suture . The method of surgically aided dilatation of the maxilla at the level of Le Fort I plane is suitable for patients up to the age of 30. In older patients , the median palatine suture should be transsected as well .

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[ "umlsterm" ]

dilatation, maxilla, conservative - surgical, method, anterior, maxilla, apparatus, dilatation, maxilla, period, patients, findings, method, maxilla, apparatus, method, dilatation, dilatation, maxilla, mono-, operation, use, method, patients, Dilatation, maxilla, postoperative, anterior, posterior, dental arch, X - ray, maxilla, patient, age, fracture, alveolar process, maxilla, method, dilatation, maxilla, patients, age, older, patients

MundKieferGesichtschirurgie.80020026.eng.abstr_task2

Sentence: The median palatine suture has long been regarded as having the greatest resistance to dilatation of the maxilla . In 1984 Glassman [ 3 ] presented a conservative-surgical method of division of the palatineal suture in which only the lateral and anterior support of the maxilla is debilitated surgically . An orthodontic apparatus cemented in place preoperatively is already used intraoperatively for dilatation of the maxilla . In the period from 1991 to 1997 , 16 patients with a leptomaxilla and various dysnathic findings have been operated on at our clinic by the method described by Glassman [ 3 ] . Sometimes the maxilla was dilated intraoperatively using the apparatus cemented in place by the method of Derichsweiler and dilatation was continued postoperatively until the described result was achieved . After successful dilatation of the maxilla and a stabilizing phase , a mono- or bimaxillary operation was performed . The use of this method led to the desired result in 15 patients . Dilatation of the maxilla was objectivized by determining the pre- and postoperative width of the anterior and posterior dental arch using models and X-ray of the occlusal overlay of the maxilla . In one patient who was operated on at the age of 38 years , a fracture of the alveolar process of the maxilla occurred unilaterally due to the completed ossification of the median palatine suture . The method of surgically aided dilatation of the maxilla at the level of Le Fort I plane is suitable for patients up to the age of 30. In older patients , the median palatine suture should be transsected as well . Instructions: please extract entity words from the input sentence

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The median palatine suture has long been regarded as having the greatest resistance to dilatation of the maxilla . In 1984 Glassman [ 3 ] presented a conservative-surgical method of division of the palatineal suture in which only the lateral and anterior support of the maxilla is debilitated surgically . An orthodontic apparatus cemented in place preoperatively is already used intraoperatively for dilatation of the maxilla . In the period from 1991 to 1997 , 16 patients with a leptomaxilla and various dysnathic findings have been operated on at our clinic by the method described by Glassman [ 3 ] . Sometimes the maxilla was dilated intraoperatively using the apparatus cemented in place by the method of Derichsweiler and dilatation was continued postoperatively until the described result was achieved . After successful dilatation of the maxilla and a stabilizing phase , a mono- or bimaxillary operation was performed . The use of this method led to the desired result in 15 patients . Dilatation of the maxilla was objectivized by determining the pre- and postoperative width of the anterior and posterior dental arch using models and X-ray of the occlusal overlay of the maxilla . In one patient who was operated on at the age of 38 years , a fracture of the alveolar process of the maxilla occurred unilaterally due to the completed ossification of the median palatine suture . The method of surgically aided dilatation of the maxilla at the level of Le Fort I plane is suitable for patients up to the age of 30. In older patients , the median palatine suture should be transsected as well .

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[ "umlsterm" ]

intercurrent infections is a Condition, sepsis is a Condition, drugs affecting immune system is a Drug, immunosuppressive drugs is a Drug, antibiotics is a Drug

NCT03539718_exc_task0

Sentence: Patients with intercurrent infections. Patients with sepsis. Patients receiving drugs affecting immune system like immunosuppressive drugs. Patients on antibiotics. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Condition, Drug

[ "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "B-Condition", "O", "O", "O", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "O", "B-Drug", "I-Drug", "O", "O", "O", "O", "B-Drug", "O", "O" ]

Patients with intercurrent infections. Patients with sepsis. Patients receiving drugs affecting immune system like immunosuppressive drugs. Patients on antibiotics.

[ "Patients", "with", "intercurrent", "infections", ".", "\n", "Patients", "with", "sepsis", ".", "\n", "Patients", "receiving", "drugs", "affecting", "immune", "system", "like", "immunosuppressive", "drugs", ".", "\n", "Patients", "on", "antibiotics", ".", "\n" ]

[ "Drug", "Condition" ]

intercurrent infections is a Condition, sepsis is a Condition, drugs affecting immune system is a Drug, immunosuppressive drugs is a Drug, antibiotics is a Drug

NCT03539718_exc_task1

Sentence: Patients with intercurrent infections. Patients with sepsis. Patients receiving drugs affecting immune system like immunosuppressive drugs. Patients on antibiotics. Instructions: please typing these entity words according to sentence: intercurrent infections, sepsis, drugs affecting immune system, immunosuppressive drugs, antibiotics Options: Condition, Drug

[ "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "B-Condition", "O", "O", "O", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "O", "B-Drug", "I-Drug", "O", "O", "O", "O", "B-Drug", "O", "O" ]

Patients with intercurrent infections. Patients with sepsis. Patients receiving drugs affecting immune system like immunosuppressive drugs. Patients on antibiotics.

[ "Patients", "with", "intercurrent", "infections", ".", "\n", "Patients", "with", "sepsis", ".", "\n", "Patients", "receiving", "drugs", "affecting", "immune", "system", "like", "immunosuppressive", "drugs", ".", "\n", "Patients", "on", "antibiotics", ".", "\n" ]

[ "Drug", "Condition" ]

intercurrent infections, sepsis, drugs affecting immune system, immunosuppressive drugs, antibiotics

NCT03539718_exc_task2

Sentence: Patients with intercurrent infections. Patients with sepsis. Patients receiving drugs affecting immune system like immunosuppressive drugs. Patients on antibiotics. Instructions: please extract entity words from the input sentence

[ "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "B-Condition", "O", "O", "O", "O", "B-Drug", "I-Drug", "I-Drug", "I-Drug", "O", "B-Drug", "I-Drug", "O", "O", "O", "O", "B-Drug", "O", "O" ]

Patients with intercurrent infections. Patients with sepsis. Patients receiving drugs affecting immune system like immunosuppressive drugs. Patients on antibiotics.

[ "Patients", "with", "intercurrent", "infections", ".", "\n", "Patients", "with", "sepsis", ".", "\n", "Patients", "receiving", "drugs", "affecting", "immune", "system", "like", "immunosuppressive", "drugs", ".", "\n", "Patients", "on", "antibiotics", ".", "\n" ]

[ "Drug", "Condition" ]

form is an umlsterm, hematuria is an umlsterm, children is an umlsterm, erythrocytes is an umlsterm, blebs is an umlsterm

MonatsschriftKinderheilkunde.71451182.eng.abstr_task0

Sentence: Aims : A special form of urinary dysmorphic erthrocyte ( G1-cell) was used to differentiate between glomerular and non-glomerular hematuria in 32 children . G1-cells are defined as doughnut shaped erythrocytes with one or more blebs . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O" ]

Aims : A special form of urinary dysmorphic erthrocyte ( G1-cell) was used to differentiate between glomerular and non-glomerular hematuria in 32 children . G1-cells are defined as doughnut shaped erythrocytes with one or more blebs .

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[ "umlsterm" ]

form is an umlsterm, hematuria is an umlsterm, children is an umlsterm, erythrocytes is an umlsterm, blebs is an umlsterm

MonatsschriftKinderheilkunde.71451182.eng.abstr_task1

Sentence: Aims : A special form of urinary dysmorphic erthrocyte ( G1-cell) was used to differentiate between glomerular and non-glomerular hematuria in 32 children . G1-cells are defined as doughnut shaped erythrocytes with one or more blebs . Instructions: please typing these entity words according to sentence: form, hematuria, children, erythrocytes, blebs Options: umlsterm

[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O" ]

Aims : A special form of urinary dysmorphic erthrocyte ( G1-cell) was used to differentiate between glomerular and non-glomerular hematuria in 32 children . G1-cells are defined as doughnut shaped erythrocytes with one or more blebs .

[ "Aims", ":", "A", "special", "form", "of", "urinary", "dysmorphic", "erthrocyte", "(", "G1-cell", ")", "was", "used", "to", "differentiate", "between", "glomerular", "and", "non", "-", "glomerular", "hematuria", "in", "32", "children", ".", "G1-cells", "are", "defined", "as", "doughnut", "shaped", "erythrocytes", "with", "one", "or", "more", "blebs", "." ]

[ "umlsterm" ]

form, hematuria, children, erythrocytes, blebs

MonatsschriftKinderheilkunde.71451182.eng.abstr_task2

Sentence: Aims : A special form of urinary dysmorphic erthrocyte ( G1-cell) was used to differentiate between glomerular and non-glomerular hematuria in 32 children . G1-cells are defined as doughnut shaped erythrocytes with one or more blebs . Instructions: please extract entity words from the input sentence

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Aims : A special form of urinary dysmorphic erthrocyte ( G1-cell) was used to differentiate between glomerular and non-glomerular hematuria in 32 children . G1-cells are defined as doughnut shaped erythrocytes with one or more blebs .

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[ "umlsterm" ]

Patienten is an umlsterm, Angina pectoris is an umlsterm, Belastung is an umlsterm, Haemangiom is an umlsterm, Arteria pulmonalis is an umlsterm, Herzohr is an umlsterm, Ergometrie is an umlsterm, Diagnostik is an umlsterm, Herztumor is an umlsterm, Tumor is an umlsterm, Patient is an umlsterm, Haemangiome is an umlsterm, Tumoren is an umlsterm

ZfuerKardiologie.70860545.ger.abstr_task0

Sentence: Ein Fall eines 73jaehrigen Patienten mit rezidivierender Angina pectoris bei Belastung , verursacht durch eine Haemangiom zwischen der Arteria pulmonalis und dem linken Herzohr , wird vorgestellt . Nach einer pathologischen Ergometrie wurde in der invasiven Diagnostik ein Herztumor diagnostiziert . Der Tumor wurde mittels medianer Sternotomie ohne extrakorporale Zirkulation entfernt . Der postoperative Verlauf war unauffaellig , und der Patient war beschwerdefrei . Haemangiome des Herzens sind seltene Tumoren , die durch eine Operation kurativ behandelt werden koennen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Ein Fall eines 73jaehrigen Patienten mit rezidivierender Angina pectoris bei Belastung , verursacht durch eine Haemangiom zwischen der Arteria pulmonalis und dem linken Herzohr , wird vorgestellt . Nach einer pathologischen Ergometrie wurde in der invasiven Diagnostik ein Herztumor diagnostiziert . Der Tumor wurde mittels medianer Sternotomie ohne extrakorporale Zirkulation entfernt . Der postoperative Verlauf war unauffaellig , und der Patient war beschwerdefrei . Haemangiome des Herzens sind seltene Tumoren , die durch eine Operation kurativ behandelt werden koennen .

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[ "umlsterm" ]

Patienten is an umlsterm, Angina pectoris is an umlsterm, Belastung is an umlsterm, Haemangiom is an umlsterm, Arteria pulmonalis is an umlsterm, Herzohr is an umlsterm, Ergometrie is an umlsterm, Diagnostik is an umlsterm, Herztumor is an umlsterm, Tumor is an umlsterm, Patient is an umlsterm, Haemangiome is an umlsterm, Tumoren is an umlsterm

ZfuerKardiologie.70860545.ger.abstr_task1

Sentence: Ein Fall eines 73jaehrigen Patienten mit rezidivierender Angina pectoris bei Belastung , verursacht durch eine Haemangiom zwischen der Arteria pulmonalis und dem linken Herzohr , wird vorgestellt . Nach einer pathologischen Ergometrie wurde in der invasiven Diagnostik ein Herztumor diagnostiziert . Der Tumor wurde mittels medianer Sternotomie ohne extrakorporale Zirkulation entfernt . Der postoperative Verlauf war unauffaellig , und der Patient war beschwerdefrei . Haemangiome des Herzens sind seltene Tumoren , die durch eine Operation kurativ behandelt werden koennen . Instructions: please typing these entity words according to sentence: Patienten, Angina pectoris, Belastung, Haemangiom, Arteria pulmonalis, Herzohr, Ergometrie, Diagnostik, Herztumor, Tumor, Patient, Haemangiome, Tumoren Options: umlsterm

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Ein Fall eines 73jaehrigen Patienten mit rezidivierender Angina pectoris bei Belastung , verursacht durch eine Haemangiom zwischen der Arteria pulmonalis und dem linken Herzohr , wird vorgestellt . Nach einer pathologischen Ergometrie wurde in der invasiven Diagnostik ein Herztumor diagnostiziert . Der Tumor wurde mittels medianer Sternotomie ohne extrakorporale Zirkulation entfernt . Der postoperative Verlauf war unauffaellig , und der Patient war beschwerdefrei . Haemangiome des Herzens sind seltene Tumoren , die durch eine Operation kurativ behandelt werden koennen .

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[ "umlsterm" ]

Patienten, Angina pectoris, Belastung, Haemangiom, Arteria pulmonalis, Herzohr, Ergometrie, Diagnostik, Herztumor, Tumor, Patient, Haemangiome, Tumoren

ZfuerKardiologie.70860545.ger.abstr_task2

Sentence: Ein Fall eines 73jaehrigen Patienten mit rezidivierender Angina pectoris bei Belastung , verursacht durch eine Haemangiom zwischen der Arteria pulmonalis und dem linken Herzohr , wird vorgestellt . Nach einer pathologischen Ergometrie wurde in der invasiven Diagnostik ein Herztumor diagnostiziert . Der Tumor wurde mittels medianer Sternotomie ohne extrakorporale Zirkulation entfernt . Der postoperative Verlauf war unauffaellig , und der Patient war beschwerdefrei . Haemangiome des Herzens sind seltene Tumoren , die durch eine Operation kurativ behandelt werden koennen . Instructions: please extract entity words from the input sentence

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Ein Fall eines 73jaehrigen Patienten mit rezidivierender Angina pectoris bei Belastung , verursacht durch eine Haemangiom zwischen der Arteria pulmonalis und dem linken Herzohr , wird vorgestellt . Nach einer pathologischen Ergometrie wurde in der invasiven Diagnostik ein Herztumor diagnostiziert . Der Tumor wurde mittels medianer Sternotomie ohne extrakorporale Zirkulation entfernt . Der postoperative Verlauf war unauffaellig , und der Patient war beschwerdefrei . Haemangiome des Herzens sind seltene Tumoren , die durch eine Operation kurativ behandelt werden koennen .

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[ "umlsterm" ]

HbA1c is a PROTEINAS, glucosa is a NORMALIZABLES, Cr is a NORMALIZABLES, colesterol is a NORMALIZABLES, c - LDL is a NORMALIZABLES, cHDL is a NORMALIZABLES, GOT is a PROTEINAS, GPT is a PROTEINAS, GGT is a PROTEINAS, albúmina is a PROTEINAS, creatinina is a NORMALIZABLES, Glucosa is a NORMALIZABLES, Metilcetona is a NORMALIZABLES, HbA1c is a PROTEINAS, Péptido C is a PROTEINAS, Anticuerpos anti - GAD is a PROTEINAS, anti - IA2 is a PROTEINAS, anti - insulina is a PROTEINAS, IAA is a PROTEINAS, Anticuerpos IgA antitransglutaminasa is a PROTEINAS, Anticuerpos anti - TG is a PROTEINAS, anti - TPO is a PROTEINAS, TSH is a PROTEINAS, HNF1 β is a PROTEINAS, insulina glargina is a PROTEINAS, insulina aspart is a PROTEINAS, fluconazol is a NORMALIZABLES, clotrimazol is a NORMALIZABLES, HbA1c is a PROTEINAS, insulina is a PROTEINAS, insulina is a PROTEINAS, transaminasas is a PROTEINAS

416_task0

Sentence: Se trata de una paciente de 25 años, natural de Ucrania, diagnosticada de diabetes secundaria a agenesia pancreática desde hace 5 años, ingresada en nuestro servicio procedente del servicio de Urgencias por una descompensación hiperglucémica cetósica no acidótica. La paciente desde el diagnóstico ha tenido un control metabólico aceptable con HbA1c menores de 7% con tratamiento dietético y ejercicio. Entre los antecedentes familiares tiene un bisabuelo diabético y padres y hermanos sanos. En la anamnesis, al ingreso la paciente refiere mal control metabólico desde hace dos meses, coincidiendo con el inicio de episodios frecuentes de infecciones urinarias, y últimamente, agravado por candidiasis vulvovaginal y paroniquia en dedos de las manos, con clínica de polidipsia, poliuria intensa y pérdida de 6,4 kg de peso durante este periodo. En la exploración física destaca: talla 167 cm; peso 38,6 kg; IMC 13,4 kg/m2; TA 120/80 mmHg; FC 116 lpm; saturación 97%. Mandíbula en farol. Tiroides grado 0. AC y AP normal. Abdomen blando y depresible, no doloroso, sin masas ni megalias. MMII sin edemas y pulsos periféricos conservados. Sensibilidad vibratoria, con monofilamento y reflejos osteotendinosos conservados. Lesiones eritematosas y pruriginosas en región vulvar y perianal sugestivas de candidiasis. Paroniquia en cuarto dedo mano derecha. Dermopatía diabética extensa en piernas y brazos. Pruebas complementarias: Hemograma normal, VSG 35 mm/h, glucosa 552 mg/dL, Cr 0,8 mg/mL, colesterol total 205 mg/dL, c-LDL 125 mg/dL, cHDL 58 mg/dL. Perfil hepático normal salvo GOT 54 UI (7-32), GPT 63 UI (5-31) y GGT 59 (7-32). Cociente albúmina/creatinina: 0,6µg/mgr. Glucosa orina 5567 mg/dL. Metilcetona en orina 50 mg/dL. HbA1c 16,2%. Péptido C basal 166 pmol/L (298-2350). Anticuerpos anti-GAD 0,2 KU/L (0-0,9), anti-IA2 0,2 KU/L (0-1) y anti-insulina (IAA) 77,2 nU/mL (N<40). Anticuerpos IgA antitransglutaminasa 0,82 KU/L (0-10). Anticuerpos anti-TG 149 (0-40) y anti-TPO 13,3 (0-35). TSH 3,1 Exploración ginecológica: útero bicorne. Exploración del fondo de ojo y retinografía normal. TC abdominopélvico con contaste: agenesia dorsal del páncreas. ECO abdominal: en riñón izquierdo múltiples quistes corticales de tamaño menor de 1 cm, difusos por todo el parénquima renal izquierdo sin evidencia de dilatación del sistema pielocalicial ni otros hallazgos. Riñón derecho normal. Ausencia de cuerpo y cola pancreática. Cultivo de exudado del panadizo creció Klebsiella oxytoca y el cultivo vulvovaginal fue positivo para Candida albicans. Con la sospecha de diabetes tipo MODY se solicitó estudio genético mediante PCR semicuantitativa fluorescente, detectándose delección en heterozigosis de, al menos, los exones del 1 al 8 del gen HNF1 β que se asocia al tipo 5. Se comenzó tratamiento con insulina glargina e insulina aspart 1,3 U/kg. Se administró fluconazol vía oral 100 mg/día (10 días) y un óvulo vaginal en dosis única de clotrimazol 400 mg, desapareciendo las lesiones micóticas. En los controles realizados posteriormente se detectan niveles de HbA1c menores del 6% con disminución progresiva de insulina hasta 0,5 U/kg a los 6 meses del ingreso. A los ocho meses desapareció la dermopatía diabética y a los 18 meses del ingreso, la paciente ha recuperado el peso inicial y los requerimientos de insulina se mantienen en 0,5 U/kg. La función renal se ha mantenido dentro de límites normales y microalbuminuria negativa. Únicamente mantiene un ligero aumento de transaminasas. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: NORMALIZABLES, PROTEINAS

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Se trata de una paciente de 25 años, natural de Ucrania, diagnosticada de diabetes secundaria a agenesia pancreática desde hace 5 años, ingresada en nuestro servicio procedente del servicio de Urgencias por una descompensación hiperglucémica cetósica no acidótica. La paciente desde el diagnóstico ha tenido un control metabólico aceptable con HbA1c menores de 7% con tratamiento dietético y ejercicio. Entre los antecedentes familiares tiene un bisabuelo diabético y padres y hermanos sanos. En la anamnesis, al ingreso la paciente refiere mal control metabólico desde hace dos meses, coincidiendo con el inicio de episodios frecuentes de infecciones urinarias, y últimamente, agravado por candidiasis vulvovaginal y paroniquia en dedos de las manos, con clínica de polidipsia, poliuria intensa y pérdida de 6,4 kg de peso durante este periodo. En la exploración física destaca: talla 167 cm; peso 38,6 kg; IMC 13,4 kg/m2; TA 120/80 mmHg; FC 116 lpm; saturación 97%. Mandíbula en farol. Tiroides grado 0. AC y AP normal. Abdomen blando y depresible, no doloroso, sin masas ni megalias. MMII sin edemas y pulsos periféricos conservados. Sensibilidad vibratoria, con monofilamento y reflejos osteotendinosos conservados. Lesiones eritematosas y pruriginosas en región vulvar y perianal sugestivas de candidiasis. Paroniquia en cuarto dedo mano derecha. Dermopatía diabética extensa en piernas y brazos. Pruebas complementarias: Hemograma normal, VSG 35 mm/h, glucosa 552 mg/dL, Cr 0,8 mg/mL, colesterol total 205 mg/dL, c-LDL 125 mg/dL, cHDL 58 mg/dL. Perfil hepático normal salvo GOT 54 UI (7-32), GPT 63 UI (5-31) y GGT 59 (7-32). Cociente albúmina/creatinina: 0,6µg/mgr. Glucosa orina 5567 mg/dL. Metilcetona en orina 50 mg/dL. HbA1c 16,2%. Péptido C basal 166 pmol/L (298-2350). Anticuerpos anti-GAD 0,2 KU/L (0-0,9), anti-IA2 0,2 KU/L (0-1) y anti-insulina (IAA) 77,2 nU/mL (N<40). Anticuerpos IgA antitransglutaminasa 0,82 KU/L (0-10). Anticuerpos anti-TG 149 (0-40) y anti-TPO 13,3 (0-35). TSH 3,1 Exploración ginecológica: útero bicorne. Exploración del fondo de ojo y retinografía normal. TC abdominopélvico con contaste: agenesia dorsal del páncreas. ECO abdominal: en riñón izquierdo múltiples quistes corticales de tamaño menor de 1 cm, difusos por todo el parénquima renal izquierdo sin evidencia de dilatación del sistema pielocalicial ni otros hallazgos. Riñón derecho normal. Ausencia de cuerpo y cola pancreática. Cultivo de exudado del panadizo creció Klebsiella oxytoca y el cultivo vulvovaginal fue positivo para Candida albicans. Con la sospecha de diabetes tipo MODY se solicitó estudio genético mediante PCR semicuantitativa fluorescente, detectándose delección en heterozigosis de, al menos, los exones del 1 al 8 del gen HNF1 β que se asocia al tipo 5. Se comenzó tratamiento con insulina glargina e insulina aspart 1,3 U/kg. Se administró fluconazol vía oral 100 mg/día (10 días) y un óvulo vaginal en dosis única de clotrimazol 400 mg, desapareciendo las lesiones micóticas. En los controles realizados posteriormente se detectan niveles de HbA1c menores del 6% con disminución progresiva de insulina hasta 0,5 U/kg a los 6 meses del ingreso. A los ocho meses desapareció la dermopatía diabética y a los 18 meses del ingreso, la paciente ha recuperado el peso inicial y los requerimientos de insulina se mantienen en 0,5 U/kg. La función renal se ha mantenido dentro de límites normales y microalbuminuria negativa. Únicamente mantiene un ligero aumento de transaminasas.

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[ "PROTEINAS", "NORMALIZABLES" ]

HbA1c is a PROTEINAS, glucosa is a NORMALIZABLES, Cr is a NORMALIZABLES, colesterol is a NORMALIZABLES, c - LDL is a NORMALIZABLES, cHDL is a NORMALIZABLES, GOT is a PROTEINAS, GPT is a PROTEINAS, GGT is a PROTEINAS, albúmina is a PROTEINAS, creatinina is a NORMALIZABLES, Glucosa is a NORMALIZABLES, Metilcetona is a NORMALIZABLES, HbA1c is a PROTEINAS, Péptido C is a PROTEINAS, Anticuerpos anti - GAD is a PROTEINAS, anti - IA2 is a PROTEINAS, anti - insulina is a PROTEINAS, IAA is a PROTEINAS, Anticuerpos IgA antitransglutaminasa is a PROTEINAS, Anticuerpos anti - TG is a PROTEINAS, anti - TPO is a PROTEINAS, TSH is a PROTEINAS, HNF1 β is a PROTEINAS, insulina glargina is a PROTEINAS, insulina aspart is a PROTEINAS, fluconazol is a NORMALIZABLES, clotrimazol is a NORMALIZABLES, HbA1c is a PROTEINAS, insulina is a PROTEINAS, insulina is a PROTEINAS, transaminasas is a PROTEINAS

416_task1

Sentence: Se trata de una paciente de 25 años, natural de Ucrania, diagnosticada de diabetes secundaria a agenesia pancreática desde hace 5 años, ingresada en nuestro servicio procedente del servicio de Urgencias por una descompensación hiperglucémica cetósica no acidótica. La paciente desde el diagnóstico ha tenido un control metabólico aceptable con HbA1c menores de 7% con tratamiento dietético y ejercicio. Entre los antecedentes familiares tiene un bisabuelo diabético y padres y hermanos sanos. En la anamnesis, al ingreso la paciente refiere mal control metabólico desde hace dos meses, coincidiendo con el inicio de episodios frecuentes de infecciones urinarias, y últimamente, agravado por candidiasis vulvovaginal y paroniquia en dedos de las manos, con clínica de polidipsia, poliuria intensa y pérdida de 6,4 kg de peso durante este periodo. En la exploración física destaca: talla 167 cm; peso 38,6 kg; IMC 13,4 kg/m2; TA 120/80 mmHg; FC 116 lpm; saturación 97%. Mandíbula en farol. Tiroides grado 0. AC y AP normal. Abdomen blando y depresible, no doloroso, sin masas ni megalias. MMII sin edemas y pulsos periféricos conservados. Sensibilidad vibratoria, con monofilamento y reflejos osteotendinosos conservados. Lesiones eritematosas y pruriginosas en región vulvar y perianal sugestivas de candidiasis. Paroniquia en cuarto dedo mano derecha. Dermopatía diabética extensa en piernas y brazos. Pruebas complementarias: Hemograma normal, VSG 35 mm/h, glucosa 552 mg/dL, Cr 0,8 mg/mL, colesterol total 205 mg/dL, c-LDL 125 mg/dL, cHDL 58 mg/dL. Perfil hepático normal salvo GOT 54 UI (7-32), GPT 63 UI (5-31) y GGT 59 (7-32). Cociente albúmina/creatinina: 0,6µg/mgr. Glucosa orina 5567 mg/dL. Metilcetona en orina 50 mg/dL. HbA1c 16,2%. Péptido C basal 166 pmol/L (298-2350). Anticuerpos anti-GAD 0,2 KU/L (0-0,9), anti-IA2 0,2 KU/L (0-1) y anti-insulina (IAA) 77,2 nU/mL (N<40). Anticuerpos IgA antitransglutaminasa 0,82 KU/L (0-10). Anticuerpos anti-TG 149 (0-40) y anti-TPO 13,3 (0-35). TSH 3,1 Exploración ginecológica: útero bicorne. Exploración del fondo de ojo y retinografía normal. TC abdominopélvico con contaste: agenesia dorsal del páncreas. ECO abdominal: en riñón izquierdo múltiples quistes corticales de tamaño menor de 1 cm, difusos por todo el parénquima renal izquierdo sin evidencia de dilatación del sistema pielocalicial ni otros hallazgos. Riñón derecho normal. Ausencia de cuerpo y cola pancreática. Cultivo de exudado del panadizo creció Klebsiella oxytoca y el cultivo vulvovaginal fue positivo para Candida albicans. Con la sospecha de diabetes tipo MODY se solicitó estudio genético mediante PCR semicuantitativa fluorescente, detectándose delección en heterozigosis de, al menos, los exones del 1 al 8 del gen HNF1 β que se asocia al tipo 5. Se comenzó tratamiento con insulina glargina e insulina aspart 1,3 U/kg. Se administró fluconazol vía oral 100 mg/día (10 días) y un óvulo vaginal en dosis única de clotrimazol 400 mg, desapareciendo las lesiones micóticas. En los controles realizados posteriormente se detectan niveles de HbA1c menores del 6% con disminución progresiva de insulina hasta 0,5 U/kg a los 6 meses del ingreso. A los ocho meses desapareció la dermopatía diabética y a los 18 meses del ingreso, la paciente ha recuperado el peso inicial y los requerimientos de insulina se mantienen en 0,5 U/kg. La función renal se ha mantenido dentro de límites normales y microalbuminuria negativa. Únicamente mantiene un ligero aumento de transaminasas. Instructions: please typing these entity words according to sentence: HbA1c, glucosa, Cr, colesterol, c - LDL, cHDL, GOT, GPT, GGT, albúmina, creatinina, Glucosa, Metilcetona, HbA1c, Péptido C, Anticuerpos anti - GAD, anti - IA2, anti - insulina, IAA, Anticuerpos IgA antitransglutaminasa, Anticuerpos anti - TG, anti - TPO, TSH, HNF1 β, insulina glargina, insulina aspart, fluconazol, clotrimazol, HbA1c, insulina, insulina, transaminasas Options: NORMALIZABLES, PROTEINAS

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Se trata de una paciente de 25 años, natural de Ucrania, diagnosticada de diabetes secundaria a agenesia pancreática desde hace 5 años, ingresada en nuestro servicio procedente del servicio de Urgencias por una descompensación hiperglucémica cetósica no acidótica. La paciente desde el diagnóstico ha tenido un control metabólico aceptable con HbA1c menores de 7% con tratamiento dietético y ejercicio. Entre los antecedentes familiares tiene un bisabuelo diabético y padres y hermanos sanos. En la anamnesis, al ingreso la paciente refiere mal control metabólico desde hace dos meses, coincidiendo con el inicio de episodios frecuentes de infecciones urinarias, y últimamente, agravado por candidiasis vulvovaginal y paroniquia en dedos de las manos, con clínica de polidipsia, poliuria intensa y pérdida de 6,4 kg de peso durante este periodo. En la exploración física destaca: talla 167 cm; peso 38,6 kg; IMC 13,4 kg/m2; TA 120/80 mmHg; FC 116 lpm; saturación 97%. Mandíbula en farol. Tiroides grado 0. AC y AP normal. Abdomen blando y depresible, no doloroso, sin masas ni megalias. MMII sin edemas y pulsos periféricos conservados. Sensibilidad vibratoria, con monofilamento y reflejos osteotendinosos conservados. Lesiones eritematosas y pruriginosas en región vulvar y perianal sugestivas de candidiasis. Paroniquia en cuarto dedo mano derecha. Dermopatía diabética extensa en piernas y brazos. Pruebas complementarias: Hemograma normal, VSG 35 mm/h, glucosa 552 mg/dL, Cr 0,8 mg/mL, colesterol total 205 mg/dL, c-LDL 125 mg/dL, cHDL 58 mg/dL. Perfil hepático normal salvo GOT 54 UI (7-32), GPT 63 UI (5-31) y GGT 59 (7-32). Cociente albúmina/creatinina: 0,6µg/mgr. Glucosa orina 5567 mg/dL. Metilcetona en orina 50 mg/dL. HbA1c 16,2%. Péptido C basal 166 pmol/L (298-2350). Anticuerpos anti-GAD 0,2 KU/L (0-0,9), anti-IA2 0,2 KU/L (0-1) y anti-insulina (IAA) 77,2 nU/mL (N<40). Anticuerpos IgA antitransglutaminasa 0,82 KU/L (0-10). Anticuerpos anti-TG 149 (0-40) y anti-TPO 13,3 (0-35). TSH 3,1 Exploración ginecológica: útero bicorne. Exploración del fondo de ojo y retinografía normal. TC abdominopélvico con contaste: agenesia dorsal del páncreas. ECO abdominal: en riñón izquierdo múltiples quistes corticales de tamaño menor de 1 cm, difusos por todo el parénquima renal izquierdo sin evidencia de dilatación del sistema pielocalicial ni otros hallazgos. Riñón derecho normal. Ausencia de cuerpo y cola pancreática. Cultivo de exudado del panadizo creció Klebsiella oxytoca y el cultivo vulvovaginal fue positivo para Candida albicans. Con la sospecha de diabetes tipo MODY se solicitó estudio genético mediante PCR semicuantitativa fluorescente, detectándose delección en heterozigosis de, al menos, los exones del 1 al 8 del gen HNF1 β que se asocia al tipo 5. Se comenzó tratamiento con insulina glargina e insulina aspart 1,3 U/kg. Se administró fluconazol vía oral 100 mg/día (10 días) y un óvulo vaginal en dosis única de clotrimazol 400 mg, desapareciendo las lesiones micóticas. En los controles realizados posteriormente se detectan niveles de HbA1c menores del 6% con disminución progresiva de insulina hasta 0,5 U/kg a los 6 meses del ingreso. A los ocho meses desapareció la dermopatía diabética y a los 18 meses del ingreso, la paciente ha recuperado el peso inicial y los requerimientos de insulina se mantienen en 0,5 U/kg. La función renal se ha mantenido dentro de límites normales y microalbuminuria negativa. Únicamente mantiene un ligero aumento de transaminasas.

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[ "PROTEINAS", "NORMALIZABLES" ]

HbA1c, glucosa, Cr, colesterol, c - LDL, cHDL, GOT, GPT, GGT, albúmina, creatinina, Glucosa, Metilcetona, HbA1c, Péptido C, Anticuerpos anti - GAD, anti - IA2, anti - insulina, IAA, Anticuerpos IgA antitransglutaminasa, Anticuerpos anti - TG, anti - TPO, TSH, HNF1 β, insulina glargina, insulina aspart, fluconazol, clotrimazol, HbA1c, insulina, insulina, transaminasas

416_task2

Sentence: Se trata de una paciente de 25 años, natural de Ucrania, diagnosticada de diabetes secundaria a agenesia pancreática desde hace 5 años, ingresada en nuestro servicio procedente del servicio de Urgencias por una descompensación hiperglucémica cetósica no acidótica. La paciente desde el diagnóstico ha tenido un control metabólico aceptable con HbA1c menores de 7% con tratamiento dietético y ejercicio. Entre los antecedentes familiares tiene un bisabuelo diabético y padres y hermanos sanos. En la anamnesis, al ingreso la paciente refiere mal control metabólico desde hace dos meses, coincidiendo con el inicio de episodios frecuentes de infecciones urinarias, y últimamente, agravado por candidiasis vulvovaginal y paroniquia en dedos de las manos, con clínica de polidipsia, poliuria intensa y pérdida de 6,4 kg de peso durante este periodo. En la exploración física destaca: talla 167 cm; peso 38,6 kg; IMC 13,4 kg/m2; TA 120/80 mmHg; FC 116 lpm; saturación 97%. Mandíbula en farol. Tiroides grado 0. AC y AP normal. Abdomen blando y depresible, no doloroso, sin masas ni megalias. MMII sin edemas y pulsos periféricos conservados. Sensibilidad vibratoria, con monofilamento y reflejos osteotendinosos conservados. Lesiones eritematosas y pruriginosas en región vulvar y perianal sugestivas de candidiasis. Paroniquia en cuarto dedo mano derecha. Dermopatía diabética extensa en piernas y brazos. Pruebas complementarias: Hemograma normal, VSG 35 mm/h, glucosa 552 mg/dL, Cr 0,8 mg/mL, colesterol total 205 mg/dL, c-LDL 125 mg/dL, cHDL 58 mg/dL. Perfil hepático normal salvo GOT 54 UI (7-32), GPT 63 UI (5-31) y GGT 59 (7-32). Cociente albúmina/creatinina: 0,6µg/mgr. Glucosa orina 5567 mg/dL. Metilcetona en orina 50 mg/dL. HbA1c 16,2%. Péptido C basal 166 pmol/L (298-2350). Anticuerpos anti-GAD 0,2 KU/L (0-0,9), anti-IA2 0,2 KU/L (0-1) y anti-insulina (IAA) 77,2 nU/mL (N<40). Anticuerpos IgA antitransglutaminasa 0,82 KU/L (0-10). Anticuerpos anti-TG 149 (0-40) y anti-TPO 13,3 (0-35). TSH 3,1 Exploración ginecológica: útero bicorne. Exploración del fondo de ojo y retinografía normal. TC abdominopélvico con contaste: agenesia dorsal del páncreas. ECO abdominal: en riñón izquierdo múltiples quistes corticales de tamaño menor de 1 cm, difusos por todo el parénquima renal izquierdo sin evidencia de dilatación del sistema pielocalicial ni otros hallazgos. Riñón derecho normal. Ausencia de cuerpo y cola pancreática. Cultivo de exudado del panadizo creció Klebsiella oxytoca y el cultivo vulvovaginal fue positivo para Candida albicans. Con la sospecha de diabetes tipo MODY se solicitó estudio genético mediante PCR semicuantitativa fluorescente, detectándose delección en heterozigosis de, al menos, los exones del 1 al 8 del gen HNF1 β que se asocia al tipo 5. Se comenzó tratamiento con insulina glargina e insulina aspart 1,3 U/kg. Se administró fluconazol vía oral 100 mg/día (10 días) y un óvulo vaginal en dosis única de clotrimazol 400 mg, desapareciendo las lesiones micóticas. En los controles realizados posteriormente se detectan niveles de HbA1c menores del 6% con disminución progresiva de insulina hasta 0,5 U/kg a los 6 meses del ingreso. A los ocho meses desapareció la dermopatía diabética y a los 18 meses del ingreso, la paciente ha recuperado el peso inicial y los requerimientos de insulina se mantienen en 0,5 U/kg. La función renal se ha mantenido dentro de límites normales y microalbuminuria negativa. Únicamente mantiene un ligero aumento de transaminasas. Instructions: please extract entity words from the input sentence

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Se trata de una paciente de 25 años, natural de Ucrania, diagnosticada de diabetes secundaria a agenesia pancreática desde hace 5 años, ingresada en nuestro servicio procedente del servicio de Urgencias por una descompensación hiperglucémica cetósica no acidótica. La paciente desde el diagnóstico ha tenido un control metabólico aceptable con HbA1c menores de 7% con tratamiento dietético y ejercicio. Entre los antecedentes familiares tiene un bisabuelo diabético y padres y hermanos sanos. En la anamnesis, al ingreso la paciente refiere mal control metabólico desde hace dos meses, coincidiendo con el inicio de episodios frecuentes de infecciones urinarias, y últimamente, agravado por candidiasis vulvovaginal y paroniquia en dedos de las manos, con clínica de polidipsia, poliuria intensa y pérdida de 6,4 kg de peso durante este periodo. En la exploración física destaca: talla 167 cm; peso 38,6 kg; IMC 13,4 kg/m2; TA 120/80 mmHg; FC 116 lpm; saturación 97%. Mandíbula en farol. Tiroides grado 0. AC y AP normal. Abdomen blando y depresible, no doloroso, sin masas ni megalias. MMII sin edemas y pulsos periféricos conservados. Sensibilidad vibratoria, con monofilamento y reflejos osteotendinosos conservados. Lesiones eritematosas y pruriginosas en región vulvar y perianal sugestivas de candidiasis. Paroniquia en cuarto dedo mano derecha. Dermopatía diabética extensa en piernas y brazos. Pruebas complementarias: Hemograma normal, VSG 35 mm/h, glucosa 552 mg/dL, Cr 0,8 mg/mL, colesterol total 205 mg/dL, c-LDL 125 mg/dL, cHDL 58 mg/dL. Perfil hepático normal salvo GOT 54 UI (7-32), GPT 63 UI (5-31) y GGT 59 (7-32). Cociente albúmina/creatinina: 0,6µg/mgr. Glucosa orina 5567 mg/dL. Metilcetona en orina 50 mg/dL. HbA1c 16,2%. Péptido C basal 166 pmol/L (298-2350). Anticuerpos anti-GAD 0,2 KU/L (0-0,9), anti-IA2 0,2 KU/L (0-1) y anti-insulina (IAA) 77,2 nU/mL (N<40). Anticuerpos IgA antitransglutaminasa 0,82 KU/L (0-10). Anticuerpos anti-TG 149 (0-40) y anti-TPO 13,3 (0-35). TSH 3,1 Exploración ginecológica: útero bicorne. Exploración del fondo de ojo y retinografía normal. TC abdominopélvico con contaste: agenesia dorsal del páncreas. ECO abdominal: en riñón izquierdo múltiples quistes corticales de tamaño menor de 1 cm, difusos por todo el parénquima renal izquierdo sin evidencia de dilatación del sistema pielocalicial ni otros hallazgos. Riñón derecho normal. Ausencia de cuerpo y cola pancreática. Cultivo de exudado del panadizo creció Klebsiella oxytoca y el cultivo vulvovaginal fue positivo para Candida albicans. Con la sospecha de diabetes tipo MODY se solicitó estudio genético mediante PCR semicuantitativa fluorescente, detectándose delección en heterozigosis de, al menos, los exones del 1 al 8 del gen HNF1 β que se asocia al tipo 5. Se comenzó tratamiento con insulina glargina e insulina aspart 1,3 U/kg. Se administró fluconazol vía oral 100 mg/día (10 días) y un óvulo vaginal en dosis única de clotrimazol 400 mg, desapareciendo las lesiones micóticas. En los controles realizados posteriormente se detectan niveles de HbA1c menores del 6% con disminución progresiva de insulina hasta 0,5 U/kg a los 6 meses del ingreso. A los ocho meses desapareció la dermopatía diabética y a los 18 meses del ingreso, la paciente ha recuperado el peso inicial y los requerimientos de insulina se mantienen en 0,5 U/kg. La función renal se ha mantenido dentro de límites normales y microalbuminuria negativa. Únicamente mantiene un ligero aumento de transaminasas.

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[ "PROTEINAS", "NORMALIZABLES" ]

alexithymia is a Intervention_Other, emotion regulation measures is a Intervention_Psychological, 12-week cognitive - behavioral intervention for alcohol dependence is a Intervention_Psychological, poorer emotion regulation skills is a Outcome_Mental, fewer percent days abstinent is a Outcome_Mental, greater alcohol dependence severity is a Outcome_Mental, several high - risk drinking situations is a Outcome_Mental, those seeking treatment for alcohol dependence . is a Participant_Condition

53474_task0

Sentence: The relationship of alexithymia to emotional dysregulation within an alcohol dependent treatment sample . Difficulties regulating emotions have implications for the development , maintenance , and recovery from alcohol problems . One construct thought to impede the regulation of emotion is alexithymia . Alexithymia is characterized by difficulties identifying , differentiating and expressing feelings , a limited imagination and fantasy life , and an externally-oriented thinking style ( e.g. , prefer talking about daily activities rather than feelings ) . Given that poor emotion regulation skills have been found to predict posttreatment levels of alcohol use , and that several defining characteristics of alexithymia bear similarity to deficits in emotion regulation skills , it is possible that alexithymia may predict poorer alcohol treatment outcomes . Thus , the present study first examined the relationship of alexithymia to several other emotion regulation measures and then investigated the impact of alexithymia on attrition and alcohol treatment outcomes in men and women ( N=77 ) enrolled in a 12-week cognitive-behavioral intervention for alcohol dependence . At baseline , higher scores on alexithymia were associated poorer emotion regulation skills , fewer percent days abstinent , greater alcohol dependence severity , and several high-risk drinking situations . Alexithymia was unrelated to attrition and to level of alcohol consumption at posttreatment . Overall , the construct of alexithymia is shown to be related to several theoretically-related constructs ( e.g. , emotion regulation , mindfulness ) but demonstrated a limited relationship to drinking outcomes in those seeking treatment for alcohol dependence . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Psychological, Intervention_Other, Participant_Condition, Outcome_Mental

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The relationship of alexithymia to emotional dysregulation within an alcohol dependent treatment sample . Difficulties regulating emotions have implications for the development , maintenance , and recovery from alcohol problems . One construct thought to impede the regulation of emotion is alexithymia . Alexithymia is characterized by difficulties identifying , differentiating and expressing feelings , a limited imagination and fantasy life , and an externally-oriented thinking style ( e.g. , prefer talking about daily activities rather than feelings ) . Given that poor emotion regulation skills have been found to predict posttreatment levels of alcohol use , and that several defining characteristics of alexithymia bear similarity to deficits in emotion regulation skills , it is possible that alexithymia may predict poorer alcohol treatment outcomes . Thus , the present study first examined the relationship of alexithymia to several other emotion regulation measures and then investigated the impact of alexithymia on attrition and alcohol treatment outcomes in men and women ( N=77 ) enrolled in a 12-week cognitive-behavioral intervention for alcohol dependence . At baseline , higher scores on alexithymia were associated poorer emotion regulation skills , fewer percent days abstinent , greater alcohol dependence severity , and several high-risk drinking situations . Alexithymia was unrelated to attrition and to level of alcohol consumption at posttreatment . Overall , the construct of alexithymia is shown to be related to several theoretically-related constructs ( e.g. , emotion regulation , mindfulness ) but demonstrated a limited relationship to drinking outcomes in those seeking treatment for alcohol dependence .

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[ "Intervention_Psychological", "Participant_Condition", "Outcome_Mental", "Intervention_Other" ]

alexithymia is a Intervention_Other, emotion regulation measures is a Intervention_Psychological, 12-week cognitive - behavioral intervention for alcohol dependence is a Intervention_Psychological, poorer emotion regulation skills is a Outcome_Mental, fewer percent days abstinent is a Outcome_Mental, greater alcohol dependence severity is a Outcome_Mental, several high - risk drinking situations is a Outcome_Mental, those seeking treatment for alcohol dependence . is a Participant_Condition

53474_task1

Sentence: The relationship of alexithymia to emotional dysregulation within an alcohol dependent treatment sample . Difficulties regulating emotions have implications for the development , maintenance , and recovery from alcohol problems . One construct thought to impede the regulation of emotion is alexithymia . Alexithymia is characterized by difficulties identifying , differentiating and expressing feelings , a limited imagination and fantasy life , and an externally-oriented thinking style ( e.g. , prefer talking about daily activities rather than feelings ) . Given that poor emotion regulation skills have been found to predict posttreatment levels of alcohol use , and that several defining characteristics of alexithymia bear similarity to deficits in emotion regulation skills , it is possible that alexithymia may predict poorer alcohol treatment outcomes . Thus , the present study first examined the relationship of alexithymia to several other emotion regulation measures and then investigated the impact of alexithymia on attrition and alcohol treatment outcomes in men and women ( N=77 ) enrolled in a 12-week cognitive-behavioral intervention for alcohol dependence . At baseline , higher scores on alexithymia were associated poorer emotion regulation skills , fewer percent days abstinent , greater alcohol dependence severity , and several high-risk drinking situations . Alexithymia was unrelated to attrition and to level of alcohol consumption at posttreatment . Overall , the construct of alexithymia is shown to be related to several theoretically-related constructs ( e.g. , emotion regulation , mindfulness ) but demonstrated a limited relationship to drinking outcomes in those seeking treatment for alcohol dependence . Instructions: please typing these entity words according to sentence: alexithymia, emotion regulation measures, 12-week cognitive - behavioral intervention for alcohol dependence, poorer emotion regulation skills, fewer percent days abstinent, greater alcohol dependence severity, several high - risk drinking situations, those seeking treatment for alcohol dependence . Options: Intervention_Psychological, Intervention_Other, Participant_Condition, Outcome_Mental

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The relationship of alexithymia to emotional dysregulation within an alcohol dependent treatment sample . Difficulties regulating emotions have implications for the development , maintenance , and recovery from alcohol problems . One construct thought to impede the regulation of emotion is alexithymia . Alexithymia is characterized by difficulties identifying , differentiating and expressing feelings , a limited imagination and fantasy life , and an externally-oriented thinking style ( e.g. , prefer talking about daily activities rather than feelings ) . Given that poor emotion regulation skills have been found to predict posttreatment levels of alcohol use , and that several defining characteristics of alexithymia bear similarity to deficits in emotion regulation skills , it is possible that alexithymia may predict poorer alcohol treatment outcomes . Thus , the present study first examined the relationship of alexithymia to several other emotion regulation measures and then investigated the impact of alexithymia on attrition and alcohol treatment outcomes in men and women ( N=77 ) enrolled in a 12-week cognitive-behavioral intervention for alcohol dependence . At baseline , higher scores on alexithymia were associated poorer emotion regulation skills , fewer percent days abstinent , greater alcohol dependence severity , and several high-risk drinking situations . Alexithymia was unrelated to attrition and to level of alcohol consumption at posttreatment . Overall , the construct of alexithymia is shown to be related to several theoretically-related constructs ( e.g. , emotion regulation , mindfulness ) but demonstrated a limited relationship to drinking outcomes in those seeking treatment for alcohol dependence .

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[ "Intervention_Psychological", "Participant_Condition", "Outcome_Mental", "Intervention_Other" ]

alexithymia, emotion regulation measures, 12-week cognitive - behavioral intervention for alcohol dependence, poorer emotion regulation skills, fewer percent days abstinent, greater alcohol dependence severity, several high - risk drinking situations, those seeking treatment for alcohol dependence .

53474_task2

Sentence: The relationship of alexithymia to emotional dysregulation within an alcohol dependent treatment sample . Difficulties regulating emotions have implications for the development , maintenance , and recovery from alcohol problems . One construct thought to impede the regulation of emotion is alexithymia . Alexithymia is characterized by difficulties identifying , differentiating and expressing feelings , a limited imagination and fantasy life , and an externally-oriented thinking style ( e.g. , prefer talking about daily activities rather than feelings ) . Given that poor emotion regulation skills have been found to predict posttreatment levels of alcohol use , and that several defining characteristics of alexithymia bear similarity to deficits in emotion regulation skills , it is possible that alexithymia may predict poorer alcohol treatment outcomes . Thus , the present study first examined the relationship of alexithymia to several other emotion regulation measures and then investigated the impact of alexithymia on attrition and alcohol treatment outcomes in men and women ( N=77 ) enrolled in a 12-week cognitive-behavioral intervention for alcohol dependence . At baseline , higher scores on alexithymia were associated poorer emotion regulation skills , fewer percent days abstinent , greater alcohol dependence severity , and several high-risk drinking situations . Alexithymia was unrelated to attrition and to level of alcohol consumption at posttreatment . Overall , the construct of alexithymia is shown to be related to several theoretically-related constructs ( e.g. , emotion regulation , mindfulness ) but demonstrated a limited relationship to drinking outcomes in those seeking treatment for alcohol dependence . Instructions: please extract entity words from the input sentence

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The relationship of alexithymia to emotional dysregulation within an alcohol dependent treatment sample . Difficulties regulating emotions have implications for the development , maintenance , and recovery from alcohol problems . One construct thought to impede the regulation of emotion is alexithymia . Alexithymia is characterized by difficulties identifying , differentiating and expressing feelings , a limited imagination and fantasy life , and an externally-oriented thinking style ( e.g. , prefer talking about daily activities rather than feelings ) . Given that poor emotion regulation skills have been found to predict posttreatment levels of alcohol use , and that several defining characteristics of alexithymia bear similarity to deficits in emotion regulation skills , it is possible that alexithymia may predict poorer alcohol treatment outcomes . Thus , the present study first examined the relationship of alexithymia to several other emotion regulation measures and then investigated the impact of alexithymia on attrition and alcohol treatment outcomes in men and women ( N=77 ) enrolled in a 12-week cognitive-behavioral intervention for alcohol dependence . At baseline , higher scores on alexithymia were associated poorer emotion regulation skills , fewer percent days abstinent , greater alcohol dependence severity , and several high-risk drinking situations . Alexithymia was unrelated to attrition and to level of alcohol consumption at posttreatment . Overall , the construct of alexithymia is shown to be related to several theoretically-related constructs ( e.g. , emotion regulation , mindfulness ) but demonstrated a limited relationship to drinking outcomes in those seeking treatment for alcohol dependence .

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[ "Intervention_Psychological", "Participant_Condition", "Outcome_Mental", "Intervention_Other" ]

Risikofaktoren is an umlsterm, Faehigkeit is an umlsterm, Leistungen is an umlsterm, Beurteilung is an umlsterm, geschulten is an umlsterm, Aerzten is an umlsterm

DerOrthopaede.80270846.ger.abstr_task0

Sentence: Voraussetzung fuer die neuropsychiatrische Begutachtung nach Beschleunigungsverletzung der HWS sind die genaue Kenntnis der Symptome und Risikofaktoren eines verzoegerten Heilverlaufs sowie die Faehigkeit zur Evaluation des Schmerzerlebens und des Krankheitsverhaltens bzw. der kognitiven Leistungen . Diese Kenntnisse ermoeglichen eine integrative Beurteilung , welche vorzugsweise von Psychiatern oder psychosomatisch geschulten Aerzten uebernommen werden soll . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O" ]

Voraussetzung fuer die neuropsychiatrische Begutachtung nach Beschleunigungsverletzung der HWS sind die genaue Kenntnis der Symptome und Risikofaktoren eines verzoegerten Heilverlaufs sowie die Faehigkeit zur Evaluation des Schmerzerlebens und des Krankheitsverhaltens bzw. der kognitiven Leistungen . Diese Kenntnisse ermoeglichen eine integrative Beurteilung , welche vorzugsweise von Psychiatern oder psychosomatisch geschulten Aerzten uebernommen werden soll .

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[ "umlsterm" ]

Risikofaktoren is an umlsterm, Faehigkeit is an umlsterm, Leistungen is an umlsterm, Beurteilung is an umlsterm, geschulten is an umlsterm, Aerzten is an umlsterm

DerOrthopaede.80270846.ger.abstr_task1

Sentence: Voraussetzung fuer die neuropsychiatrische Begutachtung nach Beschleunigungsverletzung der HWS sind die genaue Kenntnis der Symptome und Risikofaktoren eines verzoegerten Heilverlaufs sowie die Faehigkeit zur Evaluation des Schmerzerlebens und des Krankheitsverhaltens bzw. der kognitiven Leistungen . Diese Kenntnisse ermoeglichen eine integrative Beurteilung , welche vorzugsweise von Psychiatern oder psychosomatisch geschulten Aerzten uebernommen werden soll . Instructions: please typing these entity words according to sentence: Risikofaktoren, Faehigkeit, Leistungen, Beurteilung, geschulten, Aerzten Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O" ]

Voraussetzung fuer die neuropsychiatrische Begutachtung nach Beschleunigungsverletzung der HWS sind die genaue Kenntnis der Symptome und Risikofaktoren eines verzoegerten Heilverlaufs sowie die Faehigkeit zur Evaluation des Schmerzerlebens und des Krankheitsverhaltens bzw. der kognitiven Leistungen . Diese Kenntnisse ermoeglichen eine integrative Beurteilung , welche vorzugsweise von Psychiatern oder psychosomatisch geschulten Aerzten uebernommen werden soll .

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[ "umlsterm" ]

Risikofaktoren, Faehigkeit, Leistungen, Beurteilung, geschulten, Aerzten

DerOrthopaede.80270846.ger.abstr_task2

Sentence: Voraussetzung fuer die neuropsychiatrische Begutachtung nach Beschleunigungsverletzung der HWS sind die genaue Kenntnis der Symptome und Risikofaktoren eines verzoegerten Heilverlaufs sowie die Faehigkeit zur Evaluation des Schmerzerlebens und des Krankheitsverhaltens bzw. der kognitiven Leistungen . Diese Kenntnisse ermoeglichen eine integrative Beurteilung , welche vorzugsweise von Psychiatern oder psychosomatisch geschulten Aerzten uebernommen werden soll . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O" ]

Voraussetzung fuer die neuropsychiatrische Begutachtung nach Beschleunigungsverletzung der HWS sind die genaue Kenntnis der Symptome und Risikofaktoren eines verzoegerten Heilverlaufs sowie die Faehigkeit zur Evaluation des Schmerzerlebens und des Krankheitsverhaltens bzw. der kognitiven Leistungen . Diese Kenntnisse ermoeglichen eine integrative Beurteilung , welche vorzugsweise von Psychiatern oder psychosomatisch geschulten Aerzten uebernommen werden soll .

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[ "umlsterm" ]

17beta - estradiol is a compound, Akt is a protein, GSK-3beta is a protein

DS.d815_task0

Sentence: Both 17alpha- and 17beta-estradiol elicited rapid phosphorylation of p42/44MAPK, Akt, and GSK-3beta within 8 min. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein

[ "O", "O", "O", "B-compound", "I-compound", "I-compound", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein", "O", "O", "O", "O" ]

Both 17alpha- and 17beta-estradiol elicited rapid phosphorylation of p42/44MAPK, Akt, and GSK-3beta within 8 min.

[ "Both", "17alpha-", "and", "17beta", "-", "estradiol", "elicited", "rapid", "phosphorylation", "of", "p42/44MAPK", ",", "Akt", ",", "and", "GSK-3beta", "within", "8", "min", "." ]

[ "compound", "protein" ]

17beta - estradiol is a compound, Akt is a protein, GSK-3beta is a protein

DS.d815_task1

Sentence: Both 17alpha- and 17beta-estradiol elicited rapid phosphorylation of p42/44MAPK, Akt, and GSK-3beta within 8 min. Instructions: please typing these entity words according to sentence: 17beta - estradiol, Akt, GSK-3beta Options: compound, protein

[ "O", "O", "O", "B-compound", "I-compound", "I-compound", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein", "O", "O", "O", "O" ]

Both 17alpha- and 17beta-estradiol elicited rapid phosphorylation of p42/44MAPK, Akt, and GSK-3beta within 8 min.

[ "Both", "17alpha-", "and", "17beta", "-", "estradiol", "elicited", "rapid", "phosphorylation", "of", "p42/44MAPK", ",", "Akt", ",", "and", "GSK-3beta", "within", "8", "min", "." ]

[ "compound", "protein" ]

17beta - estradiol, Akt, GSK-3beta

DS.d815_task2

Sentence: Both 17alpha- and 17beta-estradiol elicited rapid phosphorylation of p42/44MAPK, Akt, and GSK-3beta within 8 min. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "B-compound", "I-compound", "I-compound", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein", "O", "O", "O", "O" ]

Both 17alpha- and 17beta-estradiol elicited rapid phosphorylation of p42/44MAPK, Akt, and GSK-3beta within 8 min.

[ "Both", "17alpha-", "and", "17beta", "-", "estradiol", "elicited", "rapid", "phosphorylation", "of", "p42/44MAPK", ",", "Akt", ",", "and", "GSK-3beta", "within", "8", "min", "." ]

[ "compound", "protein" ]

Relaxing retinotomy with silicone oil or long - acting gas is a Intervention_Physical, proliferative vitreoretinopathy is a Outcome_Physical, 117 is a Participant_Sample-size, 404 is a Participant_Sample-size, vitrectomy is a Intervention_Pharmacological, relaxing retinotomy is a Intervention_Surgical, treatment with long - acting gas or silicone oil is a Intervention_Pharmacological, Forty - six is a Participant_Sample-size, better anatomic ( six months ) is a Outcome_Physical, visual ( six and 24 months ) outcomes is a Outcome_Physical, hypotony is a Outcome_Physical, perflouropropane is a Intervention_Pharmacological, equally effective is a Outcome_Other

84781_task0

Sentence: Relaxing retinotomy with silicone oil or long-acting gas in eyes with severe proliferative vitreoretinopathy . Silicone Study Report 5 . The Silicone Study Group . In the Silicone Study , 117 of 404 eyes ( 29 % ) with severe proliferative vitreoretinopathy ( > or = C-3 , full-thickness retinal folds in three or more quadrants ) enrolled in the study were treated with vitrectomy , underwent a relaxing retinotomy , and were randomly assigned to treatment with long-acting gas or silicone oil . Forty-six eyes ( 20 % ) had undergone no previous vitrectomy ( group 1 ) ; 71 eyes ( 42 % ) had undergone previous vitrectomy ( group 2 ) with intraocular gas tamponade ( P < .001 ) . Group 1 eyes not undergoing retinotomy had better anatomic ( six months ) and visual ( six and 24 months ) outcomes and less hypotony ( six months ) than eyes that did regardless of tamponade ( P < .05 ) . For eyes undergoing retinotomy , silicone oil decreased the likelihood of hypotony ( six months , P < .05 ) . These differences were not found in group 2 eyes . We conclude that eyes undergoing a vitreous operation for the first time for the treatment of proliferative vitreoretinopathy can in most instances be successfully treated by conventional techniques without the need for relaxing retinotomy . Retinotomy may be required more often in patients undergoing repeat vitreous surgery for proliferative vitreoretinopathy , in which case both silicone oil and long-acting perflouropropane gas appear to be equally effective . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Intervention_Physical, Outcome_Physical, Participant_Sample-size, Outcome_Other, Intervention_Surgical

[ "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "B-Intervention_Surgical", "I-Intervention_Surgical", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O" ]

Relaxing retinotomy with silicone oil or long-acting gas in eyes with severe proliferative vitreoretinopathy . Silicone Study Report 5 . The Silicone Study Group . In the Silicone Study , 117 of 404 eyes ( 29 % ) with severe proliferative vitreoretinopathy ( > or = C-3 , full-thickness retinal folds in three or more quadrants ) enrolled in the study were treated with vitrectomy , underwent a relaxing retinotomy , and were randomly assigned to treatment with long-acting gas or silicone oil . Forty-six eyes ( 20 % ) had undergone no previous vitrectomy ( group 1 ) ; 71 eyes ( 42 % ) had undergone previous vitrectomy ( group 2 ) with intraocular gas tamponade ( P < .001 ) . Group 1 eyes not undergoing retinotomy had better anatomic ( six months ) and visual ( six and 24 months ) outcomes and less hypotony ( six months ) than eyes that did regardless of tamponade ( P < .05 ) . For eyes undergoing retinotomy , silicone oil decreased the likelihood of hypotony ( six months , P < .05 ) . These differences were not found in group 2 eyes . We conclude that eyes undergoing a vitreous operation for the first time for the treatment of proliferative vitreoretinopathy can in most instances be successfully treated by conventional techniques without the need for relaxing retinotomy . Retinotomy may be required more often in patients undergoing repeat vitreous surgery for proliferative vitreoretinopathy , in which case both silicone oil and long-acting perflouropropane gas appear to be equally effective .

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[ "Intervention_Physical", "Intervention_Pharmacological", "Outcome_Physical", "Participant_Condition", "Intervention_Surgical", "Outcome_Other", "Participant_Sample-size" ]

Relaxing retinotomy with silicone oil or long - acting gas is a Intervention_Physical, proliferative vitreoretinopathy is a Outcome_Physical, 117 is a Participant_Sample-size, 404 is a Participant_Sample-size, vitrectomy is a Intervention_Pharmacological, relaxing retinotomy is a Intervention_Surgical, treatment with long - acting gas or silicone oil is a Intervention_Pharmacological, Forty - six is a Participant_Sample-size, better anatomic ( six months ) is a Outcome_Physical, visual ( six and 24 months ) outcomes is a Outcome_Physical, hypotony is a Outcome_Physical, perflouropropane is a Intervention_Pharmacological, equally effective is a Outcome_Other

84781_task1

Sentence: Relaxing retinotomy with silicone oil or long-acting gas in eyes with severe proliferative vitreoretinopathy . Silicone Study Report 5 . The Silicone Study Group . In the Silicone Study , 117 of 404 eyes ( 29 % ) with severe proliferative vitreoretinopathy ( > or = C-3 , full-thickness retinal folds in three or more quadrants ) enrolled in the study were treated with vitrectomy , underwent a relaxing retinotomy , and were randomly assigned to treatment with long-acting gas or silicone oil . Forty-six eyes ( 20 % ) had undergone no previous vitrectomy ( group 1 ) ; 71 eyes ( 42 % ) had undergone previous vitrectomy ( group 2 ) with intraocular gas tamponade ( P < .001 ) . Group 1 eyes not undergoing retinotomy had better anatomic ( six months ) and visual ( six and 24 months ) outcomes and less hypotony ( six months ) than eyes that did regardless of tamponade ( P < .05 ) . For eyes undergoing retinotomy , silicone oil decreased the likelihood of hypotony ( six months , P < .05 ) . These differences were not found in group 2 eyes . We conclude that eyes undergoing a vitreous operation for the first time for the treatment of proliferative vitreoretinopathy can in most instances be successfully treated by conventional techniques without the need for relaxing retinotomy . Retinotomy may be required more often in patients undergoing repeat vitreous surgery for proliferative vitreoretinopathy , in which case both silicone oil and long-acting perflouropropane gas appear to be equally effective . Instructions: please typing these entity words according to sentence: Relaxing retinotomy with silicone oil or long - acting gas, proliferative vitreoretinopathy, 117, 404, vitrectomy, relaxing retinotomy, treatment with long - acting gas or silicone oil, Forty - six, better anatomic ( six months ), visual ( six and 24 months ) outcomes, hypotony, perflouropropane, equally effective Options: Intervention_Pharmacological, Intervention_Physical, Outcome_Physical, Participant_Sample-size, Outcome_Other, Intervention_Surgical

[ "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "B-Intervention_Surgical", "I-Intervention_Surgical", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O" ]

Relaxing retinotomy with silicone oil or long-acting gas in eyes with severe proliferative vitreoretinopathy . Silicone Study Report 5 . The Silicone Study Group . In the Silicone Study , 117 of 404 eyes ( 29 % ) with severe proliferative vitreoretinopathy ( > or = C-3 , full-thickness retinal folds in three or more quadrants ) enrolled in the study were treated with vitrectomy , underwent a relaxing retinotomy , and were randomly assigned to treatment with long-acting gas or silicone oil . Forty-six eyes ( 20 % ) had undergone no previous vitrectomy ( group 1 ) ; 71 eyes ( 42 % ) had undergone previous vitrectomy ( group 2 ) with intraocular gas tamponade ( P < .001 ) . Group 1 eyes not undergoing retinotomy had better anatomic ( six months ) and visual ( six and 24 months ) outcomes and less hypotony ( six months ) than eyes that did regardless of tamponade ( P < .05 ) . For eyes undergoing retinotomy , silicone oil decreased the likelihood of hypotony ( six months , P < .05 ) . These differences were not found in group 2 eyes . We conclude that eyes undergoing a vitreous operation for the first time for the treatment of proliferative vitreoretinopathy can in most instances be successfully treated by conventional techniques without the need for relaxing retinotomy . Retinotomy may be required more often in patients undergoing repeat vitreous surgery for proliferative vitreoretinopathy , in which case both silicone oil and long-acting perflouropropane gas appear to be equally effective .

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[ "Intervention_Physical", "Intervention_Pharmacological", "Outcome_Physical", "Participant_Condition", "Intervention_Surgical", "Outcome_Other", "Participant_Sample-size" ]

Relaxing retinotomy with silicone oil or long - acting gas, proliferative vitreoretinopathy, 117, 404, vitrectomy, relaxing retinotomy, treatment with long - acting gas or silicone oil, Forty - six, better anatomic ( six months ), visual ( six and 24 months ) outcomes, hypotony, perflouropropane, equally effective

84781_task2

Sentence: Relaxing retinotomy with silicone oil or long-acting gas in eyes with severe proliferative vitreoretinopathy . Silicone Study Report 5 . The Silicone Study Group . In the Silicone Study , 117 of 404 eyes ( 29 % ) with severe proliferative vitreoretinopathy ( > or = C-3 , full-thickness retinal folds in three or more quadrants ) enrolled in the study were treated with vitrectomy , underwent a relaxing retinotomy , and were randomly assigned to treatment with long-acting gas or silicone oil . Forty-six eyes ( 20 % ) had undergone no previous vitrectomy ( group 1 ) ; 71 eyes ( 42 % ) had undergone previous vitrectomy ( group 2 ) with intraocular gas tamponade ( P < .001 ) . Group 1 eyes not undergoing retinotomy had better anatomic ( six months ) and visual ( six and 24 months ) outcomes and less hypotony ( six months ) than eyes that did regardless of tamponade ( P < .05 ) . For eyes undergoing retinotomy , silicone oil decreased the likelihood of hypotony ( six months , P < .05 ) . These differences were not found in group 2 eyes . We conclude that eyes undergoing a vitreous operation for the first time for the treatment of proliferative vitreoretinopathy can in most instances be successfully treated by conventional techniques without the need for relaxing retinotomy . Retinotomy may be required more often in patients undergoing repeat vitreous surgery for proliferative vitreoretinopathy , in which case both silicone oil and long-acting perflouropropane gas appear to be equally effective . Instructions: please extract entity words from the input sentence

[ "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "B-Intervention_Surgical", "I-Intervention_Surgical", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O" ]

Relaxing retinotomy with silicone oil or long-acting gas in eyes with severe proliferative vitreoretinopathy . Silicone Study Report 5 . The Silicone Study Group . In the Silicone Study , 117 of 404 eyes ( 29 % ) with severe proliferative vitreoretinopathy ( > or = C-3 , full-thickness retinal folds in three or more quadrants ) enrolled in the study were treated with vitrectomy , underwent a relaxing retinotomy , and were randomly assigned to treatment with long-acting gas or silicone oil . Forty-six eyes ( 20 % ) had undergone no previous vitrectomy ( group 1 ) ; 71 eyes ( 42 % ) had undergone previous vitrectomy ( group 2 ) with intraocular gas tamponade ( P < .001 ) . Group 1 eyes not undergoing retinotomy had better anatomic ( six months ) and visual ( six and 24 months ) outcomes and less hypotony ( six months ) than eyes that did regardless of tamponade ( P < .05 ) . For eyes undergoing retinotomy , silicone oil decreased the likelihood of hypotony ( six months , P < .05 ) . These differences were not found in group 2 eyes . We conclude that eyes undergoing a vitreous operation for the first time for the treatment of proliferative vitreoretinopathy can in most instances be successfully treated by conventional techniques without the need for relaxing retinotomy . Retinotomy may be required more often in patients undergoing repeat vitreous surgery for proliferative vitreoretinopathy , in which case both silicone oil and long-acting perflouropropane gas appear to be equally effective .

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[ "Intervention_Physical", "Intervention_Pharmacological", "Outcome_Physical", "Participant_Condition", "Intervention_Surgical", "Outcome_Other", "Participant_Sample-size" ]

dihydroergotamine is a CHEMICAL, 5-HT2B is a GENE-Y, 5-HT2C is a GENE-Y

12970106_task0

Sentence: Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, CHEMICAL

[ "O", "O", "O", "B-CHEMICAL", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy.

[ "Agonist", "actions", "of", "dihydroergotamine", "at", "5-HT2B", "and", "5-HT2C", "receptors", "and", "their", "possible", "relevance", "to", "antimigraine", "efficacy", "." ]

[ "CHEMICAL", "GENE-N", "GENE-Y" ]

dihydroergotamine is a CHEMICAL, 5-HT2B is a GENE-Y, 5-HT2C is a GENE-Y

12970106_task1

Sentence: Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy. Instructions: please typing these entity words according to sentence: dihydroergotamine, 5-HT2B, 5-HT2C Options: GENE-Y, CHEMICAL

[ "O", "O", "O", "B-CHEMICAL", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy.

[ "Agonist", "actions", "of", "dihydroergotamine", "at", "5-HT2B", "and", "5-HT2C", "receptors", "and", "their", "possible", "relevance", "to", "antimigraine", "efficacy", "." ]

[ "CHEMICAL", "GENE-N", "GENE-Y" ]

dihydroergotamine, 5-HT2B, 5-HT2C

12970106_task2

Sentence: Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "B-CHEMICAL", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy.

[ "Agonist", "actions", "of", "dihydroergotamine", "at", "5-HT2B", "and", "5-HT2C", "receptors", "and", "their", "possible", "relevance", "to", "antimigraine", "efficacy", "." ]

[ "CHEMICAL", "GENE-N", "GENE-Y" ]

guanine nucleotide is a Entity, p21ras is a Protein, p21ras is a Protein, p21ras is a Protein, GTP is a Entity, p21ras is a Protein, p21ras is a Protein, p21ras is a Protein, GDP is a Entity, / GTP is a Entity, cysteine residue is a Entity, p21ras is a Protein, NF - kappa B is a Entity, p21ras is a Protein, p21ras is a Protein, p21ras is a Protein, p21ras is a Protein

169_task0

Sentence: Nitric oxide-stimulated guanine nucleotide exchange on p21ras. The protooncogene p21ras, a monomeric G protein family member, plays a critical role in converting extracellular signals into intracellular biochemical events. Here, we report that nitric oxide (NO) activates p21ras in human T cells as evidenced by an increase in GTP-bound p21ras. In vitro studies using pure recombinant p21ras demonstrate that the activation is direct and reversible. Circular dichroism analysis reveals that NO induces a profound conformational change in p21ras in association with GDP/GTP exchange. The mechanism of activation is due to S-nitrosylation of a critical cysteine residue which stimulates guanine nucleotide exchange. Furthermore, we demonstrate that p21ras is essential for NO-induced downstream signaling, such as NF-kappa B activation, and that endogenous NO can activate p21ras in the same cell. These studies identify p21ras as a target of the same cell. These studies identify p21ras as a target of NO in T cells and suggest that NO activates p21ras by an action which mimics that of guanine nucleotide exchange factors. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Entity, Protein

[ "O", "O", "O", "O", "B-Entity", "I-Entity", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "B-Entity", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Nitric oxide-stimulated guanine nucleotide exchange on p21ras. The protooncogene p21ras, a monomeric G protein family member, plays a critical role in converting extracellular signals into intracellular biochemical events. Here, we report that nitric oxide (NO) activates p21ras in human T cells as evidenced by an increase in GTP-bound p21ras. In vitro studies using pure recombinant p21ras demonstrate that the activation is direct and reversible. Circular dichroism analysis reveals that NO induces a profound conformational change in p21ras in association with GDP/GTP exchange. The mechanism of activation is due to S-nitrosylation of a critical cysteine residue which stimulates guanine nucleotide exchange. Furthermore, we demonstrate that p21ras is essential for NO-induced downstream signaling, such as NF-kappa B activation, and that endogenous NO can activate p21ras in the same cell. These studies identify p21ras as a target of the same cell. These studies identify p21ras as a target of NO in T cells and suggest that NO activates p21ras by an action which mimics that of guanine nucleotide exchange factors.

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[ "Entity", "Protein" ]

guanine nucleotide is a Entity, p21ras is a Protein, p21ras is a Protein, p21ras is a Protein, GTP is a Entity, p21ras is a Protein, p21ras is a Protein, p21ras is a Protein, GDP is a Entity, / GTP is a Entity, cysteine residue is a Entity, p21ras is a Protein, NF - kappa B is a Entity, p21ras is a Protein, p21ras is a Protein, p21ras is a Protein, p21ras is a Protein

169_task1

Sentence: Nitric oxide-stimulated guanine nucleotide exchange on p21ras. The protooncogene p21ras, a monomeric G protein family member, plays a critical role in converting extracellular signals into intracellular biochemical events. Here, we report that nitric oxide (NO) activates p21ras in human T cells as evidenced by an increase in GTP-bound p21ras. In vitro studies using pure recombinant p21ras demonstrate that the activation is direct and reversible. Circular dichroism analysis reveals that NO induces a profound conformational change in p21ras in association with GDP/GTP exchange. The mechanism of activation is due to S-nitrosylation of a critical cysteine residue which stimulates guanine nucleotide exchange. Furthermore, we demonstrate that p21ras is essential for NO-induced downstream signaling, such as NF-kappa B activation, and that endogenous NO can activate p21ras in the same cell. These studies identify p21ras as a target of the same cell. These studies identify p21ras as a target of NO in T cells and suggest that NO activates p21ras by an action which mimics that of guanine nucleotide exchange factors. Instructions: please typing these entity words according to sentence: guanine nucleotide, p21ras, p21ras, p21ras, GTP, p21ras, p21ras, p21ras, GDP, / GTP, cysteine residue, p21ras, NF - kappa B, p21ras, p21ras, p21ras, p21ras Options: Entity, Protein

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Nitric oxide-stimulated guanine nucleotide exchange on p21ras. The protooncogene p21ras, a monomeric G protein family member, plays a critical role in converting extracellular signals into intracellular biochemical events. Here, we report that nitric oxide (NO) activates p21ras in human T cells as evidenced by an increase in GTP-bound p21ras. In vitro studies using pure recombinant p21ras demonstrate that the activation is direct and reversible. Circular dichroism analysis reveals that NO induces a profound conformational change in p21ras in association with GDP/GTP exchange. The mechanism of activation is due to S-nitrosylation of a critical cysteine residue which stimulates guanine nucleotide exchange. Furthermore, we demonstrate that p21ras is essential for NO-induced downstream signaling, such as NF-kappa B activation, and that endogenous NO can activate p21ras in the same cell. These studies identify p21ras as a target of the same cell. These studies identify p21ras as a target of NO in T cells and suggest that NO activates p21ras by an action which mimics that of guanine nucleotide exchange factors.

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[ "Entity", "Protein" ]

guanine nucleotide, p21ras, p21ras, p21ras, GTP, p21ras, p21ras, p21ras, GDP, / GTP, cysteine residue, p21ras, NF - kappa B, p21ras, p21ras, p21ras, p21ras

169_task2

Sentence: Nitric oxide-stimulated guanine nucleotide exchange on p21ras. The protooncogene p21ras, a monomeric G protein family member, plays a critical role in converting extracellular signals into intracellular biochemical events. Here, we report that nitric oxide (NO) activates p21ras in human T cells as evidenced by an increase in GTP-bound p21ras. In vitro studies using pure recombinant p21ras demonstrate that the activation is direct and reversible. Circular dichroism analysis reveals that NO induces a profound conformational change in p21ras in association with GDP/GTP exchange. The mechanism of activation is due to S-nitrosylation of a critical cysteine residue which stimulates guanine nucleotide exchange. Furthermore, we demonstrate that p21ras is essential for NO-induced downstream signaling, such as NF-kappa B activation, and that endogenous NO can activate p21ras in the same cell. These studies identify p21ras as a target of the same cell. These studies identify p21ras as a target of NO in T cells and suggest that NO activates p21ras by an action which mimics that of guanine nucleotide exchange factors. Instructions: please extract entity words from the input sentence

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Nitric oxide-stimulated guanine nucleotide exchange on p21ras. The protooncogene p21ras, a monomeric G protein family member, plays a critical role in converting extracellular signals into intracellular biochemical events. Here, we report that nitric oxide (NO) activates p21ras in human T cells as evidenced by an increase in GTP-bound p21ras. In vitro studies using pure recombinant p21ras demonstrate that the activation is direct and reversible. Circular dichroism analysis reveals that NO induces a profound conformational change in p21ras in association with GDP/GTP exchange. The mechanism of activation is due to S-nitrosylation of a critical cysteine residue which stimulates guanine nucleotide exchange. Furthermore, we demonstrate that p21ras is essential for NO-induced downstream signaling, such as NF-kappa B activation, and that endogenous NO can activate p21ras in the same cell. These studies identify p21ras as a target of the same cell. These studies identify p21ras as a target of NO in T cells and suggest that NO activates p21ras by an action which mimics that of guanine nucleotide exchange factors.

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[ "Entity", "Protein" ]

atresia is an umlsterm, perfusion is an umlsterm, blood is an umlsterm, ascending aorta is an umlsterm, patients is an umlsterm, ascending aorta is an umlsterm, atresia is an umlsterm, patient is an umlsterm, hypoplastic left heart is an umlsterm, syndrome is an umlsterm, atresia is an umlsterm, mitral stenosis is an umlsterm, foramen ovale is an umlsterm, angiography is an umlsterm, sole is an umlsterm, oxygenation is an umlsterm, patient is an umlsterm, congenital is an umlsterm, heart disease is an umlsterm, atresia is an umlsterm, ascending aorta is an umlsterm, fistula is an umlsterm, perfusion is an umlsterm, blood is an umlsterm, ascending aorta is an umlsterm, atresia is an umlsterm

ZfuerKardiologie.00890502.eng.abstr_task0

Sentence: In aortic atresia , coronary perfusion normally occurs through retrograde blood flow in the ascending aorta . We report on two patients with antegrade flow in the ascending aorta despite aortic atresia . In one patient with hypoplastic left heart syndrome ( aortic atresia , severe mitral stenosis ) , an intact interatrial septum/premature closure of the foramen ovale was found . While no other way of left atrial or ventricular decompression was found , echocardiography , angiography and the post-mortem examination showed left ventricular to coronary sinusoids as the sole pathway for systemic oxygenation . In a second patient with complex congenital heart disease , including aortic atresia , antegrade flow in the ascending aorta was through a left coronary fistula with shunt flow originating from the pulmonary trunc . This report describes systemic perfusion depending on retrograde coronary flow due to coronary-cameral ( sinusoids ) and coronary arterio-venous fistulas leading to the phenomenon of antegrade blood flow in the ascending aorta despite aortic atresia . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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In aortic atresia , coronary perfusion normally occurs through retrograde blood flow in the ascending aorta . We report on two patients with antegrade flow in the ascending aorta despite aortic atresia . In one patient with hypoplastic left heart syndrome ( aortic atresia , severe mitral stenosis ) , an intact interatrial septum/premature closure of the foramen ovale was found . While no other way of left atrial or ventricular decompression was found , echocardiography , angiography and the post-mortem examination showed left ventricular to coronary sinusoids as the sole pathway for systemic oxygenation . In a second patient with complex congenital heart disease , including aortic atresia , antegrade flow in the ascending aorta was through a left coronary fistula with shunt flow originating from the pulmonary trunc . This report describes systemic perfusion depending on retrograde coronary flow due to coronary-cameral ( sinusoids ) and coronary arterio-venous fistulas leading to the phenomenon of antegrade blood flow in the ascending aorta despite aortic atresia .

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[ "umlsterm" ]

atresia is an umlsterm, perfusion is an umlsterm, blood is an umlsterm, ascending aorta is an umlsterm, patients is an umlsterm, ascending aorta is an umlsterm, atresia is an umlsterm, patient is an umlsterm, hypoplastic left heart is an umlsterm, syndrome is an umlsterm, atresia is an umlsterm, mitral stenosis is an umlsterm, foramen ovale is an umlsterm, angiography is an umlsterm, sole is an umlsterm, oxygenation is an umlsterm, patient is an umlsterm, congenital is an umlsterm, heart disease is an umlsterm, atresia is an umlsterm, ascending aorta is an umlsterm, fistula is an umlsterm, perfusion is an umlsterm, blood is an umlsterm, ascending aorta is an umlsterm, atresia is an umlsterm

ZfuerKardiologie.00890502.eng.abstr_task1

Sentence: In aortic atresia , coronary perfusion normally occurs through retrograde blood flow in the ascending aorta . We report on two patients with antegrade flow in the ascending aorta despite aortic atresia . In one patient with hypoplastic left heart syndrome ( aortic atresia , severe mitral stenosis ) , an intact interatrial septum/premature closure of the foramen ovale was found . While no other way of left atrial or ventricular decompression was found , echocardiography , angiography and the post-mortem examination showed left ventricular to coronary sinusoids as the sole pathway for systemic oxygenation . In a second patient with complex congenital heart disease , including aortic atresia , antegrade flow in the ascending aorta was through a left coronary fistula with shunt flow originating from the pulmonary trunc . This report describes systemic perfusion depending on retrograde coronary flow due to coronary-cameral ( sinusoids ) and coronary arterio-venous fistulas leading to the phenomenon of antegrade blood flow in the ascending aorta despite aortic atresia . Instructions: please typing these entity words according to sentence: atresia, perfusion, blood, ascending aorta, patients, ascending aorta, atresia, patient, hypoplastic left heart, syndrome, atresia, mitral stenosis, foramen ovale, angiography, sole, oxygenation, patient, congenital, heart disease, atresia, ascending aorta, fistula, perfusion, blood, ascending aorta, atresia Options: umlsterm

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In aortic atresia , coronary perfusion normally occurs through retrograde blood flow in the ascending aorta . We report on two patients with antegrade flow in the ascending aorta despite aortic atresia . In one patient with hypoplastic left heart syndrome ( aortic atresia , severe mitral stenosis ) , an intact interatrial septum/premature closure of the foramen ovale was found . While no other way of left atrial or ventricular decompression was found , echocardiography , angiography and the post-mortem examination showed left ventricular to coronary sinusoids as the sole pathway for systemic oxygenation . In a second patient with complex congenital heart disease , including aortic atresia , antegrade flow in the ascending aorta was through a left coronary fistula with shunt flow originating from the pulmonary trunc . This report describes systemic perfusion depending on retrograde coronary flow due to coronary-cameral ( sinusoids ) and coronary arterio-venous fistulas leading to the phenomenon of antegrade blood flow in the ascending aorta despite aortic atresia .

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[ "umlsterm" ]

atresia, perfusion, blood, ascending aorta, patients, ascending aorta, atresia, patient, hypoplastic left heart, syndrome, atresia, mitral stenosis, foramen ovale, angiography, sole, oxygenation, patient, congenital, heart disease, atresia, ascending aorta, fistula, perfusion, blood, ascending aorta, atresia

ZfuerKardiologie.00890502.eng.abstr_task2

Sentence: In aortic atresia , coronary perfusion normally occurs through retrograde blood flow in the ascending aorta . We report on two patients with antegrade flow in the ascending aorta despite aortic atresia . In one patient with hypoplastic left heart syndrome ( aortic atresia , severe mitral stenosis ) , an intact interatrial septum/premature closure of the foramen ovale was found . While no other way of left atrial or ventricular decompression was found , echocardiography , angiography and the post-mortem examination showed left ventricular to coronary sinusoids as the sole pathway for systemic oxygenation . In a second patient with complex congenital heart disease , including aortic atresia , antegrade flow in the ascending aorta was through a left coronary fistula with shunt flow originating from the pulmonary trunc . This report describes systemic perfusion depending on retrograde coronary flow due to coronary-cameral ( sinusoids ) and coronary arterio-venous fistulas leading to the phenomenon of antegrade blood flow in the ascending aorta despite aortic atresia . Instructions: please extract entity words from the input sentence

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In aortic atresia , coronary perfusion normally occurs through retrograde blood flow in the ascending aorta . We report on two patients with antegrade flow in the ascending aorta despite aortic atresia . In one patient with hypoplastic left heart syndrome ( aortic atresia , severe mitral stenosis ) , an intact interatrial septum/premature closure of the foramen ovale was found . While no other way of left atrial or ventricular decompression was found , echocardiography , angiography and the post-mortem examination showed left ventricular to coronary sinusoids as the sole pathway for systemic oxygenation . In a second patient with complex congenital heart disease , including aortic atresia , antegrade flow in the ascending aorta was through a left coronary fistula with shunt flow originating from the pulmonary trunc . This report describes systemic perfusion depending on retrograde coronary flow due to coronary-cameral ( sinusoids ) and coronary arterio-venous fistulas leading to the phenomenon of antegrade blood flow in the ascending aorta despite aortic atresia .

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[ "umlsterm" ]

aversive stimulation and failure is a Intervention_Physical, aversive stimulus and simultaneous failure on a bogus intelligence test is a Intervention_Physical, aggressive reactions is a Outcome_Mental, subject ' s fist clenching is a Participant_Condition, indicator of aggression is a Outcome_Mental, aversive or nonaversive is a Intervention_Physical, aversive or nonaversive acoustic signal is a Intervention_Physical, autonomic arousal , is a Outcome_Mental, speed of clenching is a Outcome_Mental, tendencies to aggression is a Outcome_Mental

3472_task0

Sentence: Human motor responses to simultaneous aversive stimulation and failure on a valued task . The effects of presentation of an aversive stimulus and simultaneous failure on a bogus intelligence test upon a subject 's aggressive reactions were studied . The subject 's fist clenching was used as an indicator of aggression . Four conditions , generated by the combinations of two kinds of stimulus delivered to the subjects ( aversive or nonaversive ) and two outcomes of the task ( failure or success ) , were investigated . 20 female and 20 male students ( ages : 17-34 years ) were instructed , upon the reception of an aversive or nonaversive acoustic signal , to press with the right hand a device that displayed a slide . Each slide presented an item from an intelligence test , to which the subjects were either allowed to answer successfully ( success ) or not ( failure ) . Failure increased the subject 's autonomic arousal , as measured by photoplethysmographic sensors , in all stimulation conditions , but only the condition with aversive stimulation increased the speed of clenching . This was interpreted as indicating subject 's tendencies to aggression . These results are discussed in relation to the effects of frustration . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Physical, Participant_Condition, Outcome_Mental

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Human motor responses to simultaneous aversive stimulation and failure on a valued task . The effects of presentation of an aversive stimulus and simultaneous failure on a bogus intelligence test upon a subject 's aggressive reactions were studied . The subject 's fist clenching was used as an indicator of aggression . Four conditions , generated by the combinations of two kinds of stimulus delivered to the subjects ( aversive or nonaversive ) and two outcomes of the task ( failure or success ) , were investigated . 20 female and 20 male students ( ages : 17-34 years ) were instructed , upon the reception of an aversive or nonaversive acoustic signal , to press with the right hand a device that displayed a slide . Each slide presented an item from an intelligence test , to which the subjects were either allowed to answer successfully ( success ) or not ( failure ) . Failure increased the subject 's autonomic arousal , as measured by photoplethysmographic sensors , in all stimulation conditions , but only the condition with aversive stimulation increased the speed of clenching . This was interpreted as indicating subject 's tendencies to aggression . These results are discussed in relation to the effects of frustration .

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[ "Intervention_Physical", "Participant_Condition", "Outcome_Mental" ]

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3472_task1

Sentence: Human motor responses to simultaneous aversive stimulation and failure on a valued task . The effects of presentation of an aversive stimulus and simultaneous failure on a bogus intelligence test upon a subject 's aggressive reactions were studied . The subject 's fist clenching was used as an indicator of aggression . Four conditions , generated by the combinations of two kinds of stimulus delivered to the subjects ( aversive or nonaversive ) and two outcomes of the task ( failure or success ) , were investigated . 20 female and 20 male students ( ages : 17-34 years ) were instructed , upon the reception of an aversive or nonaversive acoustic signal , to press with the right hand a device that displayed a slide . Each slide presented an item from an intelligence test , to which the subjects were either allowed to answer successfully ( success ) or not ( failure ) . Failure increased the subject 's autonomic arousal , as measured by photoplethysmographic sensors , in all stimulation conditions , but only the condition with aversive stimulation increased the speed of clenching . This was interpreted as indicating subject 's tendencies to aggression . These results are discussed in relation to the effects of frustration . Instructions: please typing these entity words according to sentence: aversive stimulation and failure, aversive stimulus and simultaneous failure on a bogus intelligence test, aggressive reactions, subject ' s fist clenching, indicator of aggression, aversive or nonaversive, aversive or nonaversive acoustic signal, autonomic arousal ,, speed of clenching, tendencies to aggression Options: Intervention_Physical, Participant_Condition, Outcome_Mental

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Human motor responses to simultaneous aversive stimulation and failure on a valued task . The effects of presentation of an aversive stimulus and simultaneous failure on a bogus intelligence test upon a subject 's aggressive reactions were studied . The subject 's fist clenching was used as an indicator of aggression . Four conditions , generated by the combinations of two kinds of stimulus delivered to the subjects ( aversive or nonaversive ) and two outcomes of the task ( failure or success ) , were investigated . 20 female and 20 male students ( ages : 17-34 years ) were instructed , upon the reception of an aversive or nonaversive acoustic signal , to press with the right hand a device that displayed a slide . Each slide presented an item from an intelligence test , to which the subjects were either allowed to answer successfully ( success ) or not ( failure ) . Failure increased the subject 's autonomic arousal , as measured by photoplethysmographic sensors , in all stimulation conditions , but only the condition with aversive stimulation increased the speed of clenching . This was interpreted as indicating subject 's tendencies to aggression . These results are discussed in relation to the effects of frustration .

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[ "Intervention_Physical", "Participant_Condition", "Outcome_Mental" ]

aversive stimulation and failure, aversive stimulus and simultaneous failure on a bogus intelligence test, aggressive reactions, subject ' s fist clenching, indicator of aggression, aversive or nonaversive, aversive or nonaversive acoustic signal, autonomic arousal ,, speed of clenching, tendencies to aggression

3472_task2

Sentence: Human motor responses to simultaneous aversive stimulation and failure on a valued task . The effects of presentation of an aversive stimulus and simultaneous failure on a bogus intelligence test upon a subject 's aggressive reactions were studied . The subject 's fist clenching was used as an indicator of aggression . Four conditions , generated by the combinations of two kinds of stimulus delivered to the subjects ( aversive or nonaversive ) and two outcomes of the task ( failure or success ) , were investigated . 20 female and 20 male students ( ages : 17-34 years ) were instructed , upon the reception of an aversive or nonaversive acoustic signal , to press with the right hand a device that displayed a slide . Each slide presented an item from an intelligence test , to which the subjects were either allowed to answer successfully ( success ) or not ( failure ) . Failure increased the subject 's autonomic arousal , as measured by photoplethysmographic sensors , in all stimulation conditions , but only the condition with aversive stimulation increased the speed of clenching . This was interpreted as indicating subject 's tendencies to aggression . These results are discussed in relation to the effects of frustration . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Human motor responses to simultaneous aversive stimulation and failure on a valued task . The effects of presentation of an aversive stimulus and simultaneous failure on a bogus intelligence test upon a subject 's aggressive reactions were studied . The subject 's fist clenching was used as an indicator of aggression . Four conditions , generated by the combinations of two kinds of stimulus delivered to the subjects ( aversive or nonaversive ) and two outcomes of the task ( failure or success ) , were investigated . 20 female and 20 male students ( ages : 17-34 years ) were instructed , upon the reception of an aversive or nonaversive acoustic signal , to press with the right hand a device that displayed a slide . Each slide presented an item from an intelligence test , to which the subjects were either allowed to answer successfully ( success ) or not ( failure ) . Failure increased the subject 's autonomic arousal , as measured by photoplethysmographic sensors , in all stimulation conditions , but only the condition with aversive stimulation increased the speed of clenching . This was interpreted as indicating subject 's tendencies to aggression . These results are discussed in relation to the effects of frustration .

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[ "Intervention_Physical", "Participant_Condition", "Outcome_Mental" ]

complicated UTI is a Condition, temperature > 38 ° C , loin tenderness is a Scope, conditions is a Condition, complicated infections is a Condition, renal diseases , patients with urinary catheter is a Scope, self - medication is a Qualifier, UU preparations is a Drug, z. B. Cystinol ® , Uvalysat ® , Arctuvan ® is a Scope, antibiotic is a Drug, last 7 days is a Temporal, UTI is a Condition, past 2 weeks is a Temporal, pyelonephritis is a Condition, contraindications for is a Mood, trial is a Qualifier, drugs is a Drug, serious is a Qualifier, diseases is a Condition

NCT03151603_exc_task0

Sentence: signs of complicated UTI (e. g. temperature > 38°C, loin tenderness) conditions that may lead to complicated infections (i.e. renal diseases, patients with urinary catheter) pregnancy/ breastfeeding current self-medication with UU preparations e.g. z.B. Cystinol®, Uvalysat®, Arctuvan® antibiotic use in the last 7 days previous UTI in the past 2 weeks history of pyelonephritis contraindications for trial drugs serious diseases inability to understand trial Information current participation in another clinical trial or participation in another clinical trial within the last 4 weeks Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Temporal, Condition, Qualifier, Scope, Mood, Drug

[ "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "B-Condition", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "O", "B-Drug", "I-Drug", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Drug", "O", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Condition", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "B-Condition", "O", "B-Mood", "I-Mood", "B-Qualifier", "B-Drug", "O", "B-Qualifier", "B-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

signs of complicated UTI (e. g. temperature > 38°C, loin tenderness) conditions that may lead to complicated infections (i.e. renal diseases, patients with urinary catheter) pregnancy/ breastfeeding current self-medication with UU preparations e.g. z.B. Cystinol®, Uvalysat®, Arctuvan® antibiotic use in the last 7 days previous UTI in the past 2 weeks history of pyelonephritis contraindications for trial drugs serious diseases inability to understand trial Information current participation in another clinical trial or participation in another clinical trial within the last 4 weeks

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[ "Scope", "Condition", "Mood", "Device", "Drug", "Qualifier", "Temporal", "Measurement", "Person", "Value" ]

complicated UTI is a Condition, temperature > 38 ° C , loin tenderness is a Scope, conditions is a Condition, complicated infections is a Condition, renal diseases , patients with urinary catheter is a Scope, self - medication is a Qualifier, UU preparations is a Drug, z. B. Cystinol ® , Uvalysat ® , Arctuvan ® is a Scope, antibiotic is a Drug, last 7 days is a Temporal, UTI is a Condition, past 2 weeks is a Temporal, pyelonephritis is a Condition, contraindications for is a Mood, trial is a Qualifier, drugs is a Drug, serious is a Qualifier, diseases is a Condition

NCT03151603_exc_task1

Sentence: signs of complicated UTI (e. g. temperature > 38°C, loin tenderness) conditions that may lead to complicated infections (i.e. renal diseases, patients with urinary catheter) pregnancy/ breastfeeding current self-medication with UU preparations e.g. z.B. Cystinol®, Uvalysat®, Arctuvan® antibiotic use in the last 7 days previous UTI in the past 2 weeks history of pyelonephritis contraindications for trial drugs serious diseases inability to understand trial Information current participation in another clinical trial or participation in another clinical trial within the last 4 weeks Instructions: please typing these entity words according to sentence: complicated UTI, temperature > 38 ° C , loin tenderness, conditions, complicated infections, renal diseases , patients with urinary catheter, self - medication, UU preparations, z. B. Cystinol ® , Uvalysat ® , Arctuvan ®, antibiotic, last 7 days, UTI, past 2 weeks, pyelonephritis, contraindications for, trial, drugs, serious, diseases Options: Temporal, Condition, Qualifier, Scope, Mood, Drug

[ "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "B-Condition", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "O", "B-Drug", "I-Drug", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Drug", "O", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Condition", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "B-Condition", "O", "B-Mood", "I-Mood", "B-Qualifier", "B-Drug", "O", "B-Qualifier", "B-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

signs of complicated UTI (e. g. temperature > 38°C, loin tenderness) conditions that may lead to complicated infections (i.e. renal diseases, patients with urinary catheter) pregnancy/ breastfeeding current self-medication with UU preparations e.g. z.B. Cystinol®, Uvalysat®, Arctuvan® antibiotic use in the last 7 days previous UTI in the past 2 weeks history of pyelonephritis contraindications for trial drugs serious diseases inability to understand trial Information current participation in another clinical trial or participation in another clinical trial within the last 4 weeks

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[ "Scope", "Condition", "Mood", "Device", "Drug", "Qualifier", "Temporal", "Measurement", "Person", "Value" ]

complicated UTI, temperature > 38 ° C , loin tenderness, conditions, complicated infections, renal diseases , patients with urinary catheter, self - medication, UU preparations, z. B. Cystinol ® , Uvalysat ® , Arctuvan ®, antibiotic, last 7 days, UTI, past 2 weeks, pyelonephritis, contraindications for, trial, drugs, serious, diseases

NCT03151603_exc_task2

Sentence: signs of complicated UTI (e. g. temperature > 38°C, loin tenderness) conditions that may lead to complicated infections (i.e. renal diseases, patients with urinary catheter) pregnancy/ breastfeeding current self-medication with UU preparations e.g. z.B. Cystinol®, Uvalysat®, Arctuvan® antibiotic use in the last 7 days previous UTI in the past 2 weeks history of pyelonephritis contraindications for trial drugs serious diseases inability to understand trial Information current participation in another clinical trial or participation in another clinical trial within the last 4 weeks Instructions: please extract entity words from the input sentence

[ "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "B-Condition", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "O", "B-Drug", "I-Drug", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Drug", "O", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Condition", "O", "O", "B-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "B-Condition", "O", "B-Mood", "I-Mood", "B-Qualifier", "B-Drug", "O", "B-Qualifier", "B-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

signs of complicated UTI (e. g. temperature > 38°C, loin tenderness) conditions that may lead to complicated infections (i.e. renal diseases, patients with urinary catheter) pregnancy/ breastfeeding current self-medication with UU preparations e.g. z.B. Cystinol®, Uvalysat®, Arctuvan® antibiotic use in the last 7 days previous UTI in the past 2 weeks history of pyelonephritis contraindications for trial drugs serious diseases inability to understand trial Information current participation in another clinical trial or participation in another clinical trial within the last 4 weeks

[ "signs", "of", "complicated", "UTI", "(", "e.", "g.", "temperature", ">", "38", "°", "C", ",", "loin", "tenderness", ")", "\n", "conditions", "that", "may", "lead", "to", "complicated", "infections", "(", "i.e", ".", "renal", "diseases", ",", "patients", "with", "urinary", "catheter", ")", "\n", "pregnancy/", "breastfeeding", "\n", "current", "self", "-", "medication", "with", "UU", "preparations", "e.g", ".", "z.", "B.", "Cystinol", "®", ",", "Uvalysat", "®", ",", "Arctuvan", "®", "\n", "antibiotic", "use", "in", "the", "last", "7", "days", "\n", "previous", "UTI", "in", "the", "past", "2", "weeks", "\n", "history", "of", "pyelonephritis", "\n", "contraindications", "for", "trial", "drugs", "\n", "serious", "diseases", "\n", "inability", "to", "understand", "trial", "Information", "\n", "current", "participation", "in", "another", "clinical", "trial", "or", "participation", "in", "another", "clinical", "trial", "within", "the", "last", "4", "weeks", "\n" ]

[ "Scope", "Condition", "Mood", "Device", "Drug", "Qualifier", "Temporal", "Measurement", "Person", "Value" ]

Bayesian adaptive comparative effectiveness trial is an intervention, status epilepticus is a participant

292_task0

Sentence: We present a novel Bayesian adaptive comparative effectiveness trial comparing three treatments for status epilepticus that uses adaptive randomization with potential early stopping . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: intervention, participant

[ "O", "O", "O", "O", "B-intervention", "I-intervention", "I-intervention", "I-intervention", "I-intervention", "O", "O", "O", "O", "B-participant", "I-participant", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

We present a novel Bayesian adaptive comparative effectiveness trial comparing three treatments for status epilepticus that uses adaptive randomization with potential early stopping .

[ "We", "present", "a", "novel", "Bayesian", "adaptive", "comparative", "effectiveness", "trial", "comparing", "three", "treatments", "for", "status", "epilepticus", "that", "uses", "adaptive", "randomization", "with", "potential", "early", "stopping", "." ]

[ "intervention", "participant", "outcome" ]

Bayesian adaptive comparative effectiveness trial is an intervention, status epilepticus is a participant

292_task1

Sentence: We present a novel Bayesian adaptive comparative effectiveness trial comparing three treatments for status epilepticus that uses adaptive randomization with potential early stopping . Instructions: please typing these entity words according to sentence: Bayesian adaptive comparative effectiveness trial, status epilepticus Options: intervention, participant

[ "O", "O", "O", "O", "B-intervention", "I-intervention", "I-intervention", "I-intervention", "I-intervention", "O", "O", "O", "O", "B-participant", "I-participant", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

We present a novel Bayesian adaptive comparative effectiveness trial comparing three treatments for status epilepticus that uses adaptive randomization with potential early stopping .

[ "We", "present", "a", "novel", "Bayesian", "adaptive", "comparative", "effectiveness", "trial", "comparing", "three", "treatments", "for", "status", "epilepticus", "that", "uses", "adaptive", "randomization", "with", "potential", "early", "stopping", "." ]

[ "intervention", "participant", "outcome" ]

Bayesian adaptive comparative effectiveness trial, status epilepticus

292_task2

Sentence: We present a novel Bayesian adaptive comparative effectiveness trial comparing three treatments for status epilepticus that uses adaptive randomization with potential early stopping . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "B-intervention", "I-intervention", "I-intervention", "I-intervention", "I-intervention", "O", "O", "O", "O", "B-participant", "I-participant", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

We present a novel Bayesian adaptive comparative effectiveness trial comparing three treatments for status epilepticus that uses adaptive randomization with potential early stopping .

[ "We", "present", "a", "novel", "Bayesian", "adaptive", "comparative", "effectiveness", "trial", "comparing", "three", "treatments", "for", "status", "epilepticus", "that", "uses", "adaptive", "randomization", "with", "potential", "early", "stopping", "." ]

[ "intervention", "participant", "outcome" ]

Patienten is an umlsterm, Tumorprophylaxe is an umlsterm, Hypertriglyzeridaemie is an umlsterm, Hautveraenderungen is an umlsterm, Restkeratosen is an umlsterm, Langzeitergebnisse is an umlsterm

DerHautarzt.80490586.ger.abstr_task0

Sentence: Wir berichten ueber einen Patienten mit kongenitaler Poikilodermie Typ Dowling , bei dem seit dem 52. Lebensjahr wiederholt M. Bowen und initiale Spinaliome in den Arealen der verruziformen Hyperkeratosen aufgetreten und exzidiert worden sind . Da eine laengerfristige Tumorprophylaxe mit Retinoiden wegen einer Hypertriglyzeridaemie Typ IV ( nach Frederickson ) nicht durchfuehrbar war , entschlossen wir uns zu einem Behandlungsversuch mittels Dermabrasio . In einem Nachbeobachtungszeitraum von 12 Monaten zeigten sich mehrere komplett abgeheilte Hautveraenderungen , daneben in einigen Arealen noch kleinere verbliebene Restkeratosen . Langzeitergebnisse stehen noch aus . Anhand des vorgestellten Falles wird das heterogene Krankheitsbild der kongenitalen Poikilodermie Typ Dowling diskutiert und auf das hohe Entartungsrisiko hingewiesen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Wir berichten ueber einen Patienten mit kongenitaler Poikilodermie Typ Dowling , bei dem seit dem 52. Lebensjahr wiederholt M. Bowen und initiale Spinaliome in den Arealen der verruziformen Hyperkeratosen aufgetreten und exzidiert worden sind . Da eine laengerfristige Tumorprophylaxe mit Retinoiden wegen einer Hypertriglyzeridaemie Typ IV ( nach Frederickson ) nicht durchfuehrbar war , entschlossen wir uns zu einem Behandlungsversuch mittels Dermabrasio . In einem Nachbeobachtungszeitraum von 12 Monaten zeigten sich mehrere komplett abgeheilte Hautveraenderungen , daneben in einigen Arealen noch kleinere verbliebene Restkeratosen . Langzeitergebnisse stehen noch aus . Anhand des vorgestellten Falles wird das heterogene Krankheitsbild der kongenitalen Poikilodermie Typ Dowling diskutiert und auf das hohe Entartungsrisiko hingewiesen .

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