bio-datasets/bigbio-ner-merged · Datasets at Hugging Face

answer stringlengths 1 16.1k	id stringlengths 7 56	instruction stringlengths 106 72.6k	ner_tags list	text stringlengths 5 72.4k	tokens list	types list
Skelettdysplasien is an umlsterm, Sklerose is an umlsterm, Schaedels is an umlsterm, Diagnosestellung is an umlsterm, maennliches is an umlsterm, Kleinkind is an umlsterm, Hypertelorismus is an umlsterm, Zahnirregularitaeten is an umlsterm, Mutter is an umlsterm, Patienten is an umlsterm, Stigmata is an umlsterm, Roentgenaufnahmen is an umlsterm, Schaedel is an umlsterm, Femur is an umlsterm, Patient is an umlsterm, Mutter is an umlsterm, Diagnose is an umlsterm, Knochenstoffwechsels is an umlsterm, Kindes is an umlsterm, Osteoblasten is an umlsterm, Hirnnervenkompression is an umlsterm, Komplikation is an umlsterm, Vomer is an umlsterm, Diagnosestellung is an umlsterm, Komplikationen is an umlsterm	MonatsschriftKinderheilkunde.61441073.ger.abstr_task0	Sentence: Die kraniometaphysaere Dysplasie stellt eine seltene Unterform der sklerosierenden Skelettdysplasien mit klinischer Manifestation im fruehen Kleinkindesalter dar , die mit einer deutlichen Sklerose des gesamten Schaedels und mit einer Aufweitung der Metaphysen der langen Roehrenknochen einhergeht . Wir berichten ueber ein zum Zeitpunkt der Diagnosestellung 18 Monate altes maennliches Kleinkind , das mit zunehmendem Makrozephalus , chronischer Nasenatmungsbehinderung und einer Gesichtsdysmorphie ( Hypertelorismus , breite Nasenwurzel , Zahnirregularitaeten ) auffaellig wurde . Die Mutter des Patienten wies aehnliche Stigmata auf . Durch Roentgenaufnahmen von Schaedel und Femur bei Patient und Mutter konnte die Diagnose gestellt werden . Untersuchungen des Knochenstoffwechsels des betroffenen Kindes weisen auf eine Ueberaktivitaet der Osteoblasten hin . Eine Hirnnervenkompression als typische Komplikation des Krankheitsbilds konnte ausgeschlossen werden . Die krankheitsbedingte Nasenatmungsbehinderung machte jedoch eine Choanalerweiterung durch Resektion des posterioren Vomer notwendig . Die Kenntnis dieses Krankheitsbilds erlaubt eine rechtzeitige Diagnosestellung und Intervention bei Komplikationen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O" ]	Die kraniometaphysaere Dysplasie stellt eine seltene Unterform der sklerosierenden Skelettdysplasien mit klinischer Manifestation im fruehen Kleinkindesalter dar , die mit einer deutlichen Sklerose des gesamten Schaedels und mit einer Aufweitung der Metaphysen der langen Roehrenknochen einhergeht . Wir berichten ueber ein zum Zeitpunkt der Diagnosestellung 18 Monate altes maennliches Kleinkind , das mit zunehmendem Makrozephalus , chronischer Nasenatmungsbehinderung und einer Gesichtsdysmorphie ( Hypertelorismus , breite Nasenwurzel , Zahnirregularitaeten ) auffaellig wurde . Die Mutter des Patienten wies aehnliche Stigmata auf . Durch Roentgenaufnahmen von Schaedel und Femur bei Patient und Mutter konnte die Diagnose gestellt werden . Untersuchungen des Knochenstoffwechsels des betroffenen Kindes weisen auf eine Ueberaktivitaet der Osteoblasten hin . Eine Hirnnervenkompression als typische Komplikation des Krankheitsbilds konnte ausgeschlossen werden . Die krankheitsbedingte Nasenatmungsbehinderung machte jedoch eine Choanalerweiterung durch Resektion des posterioren Vomer notwendig . Die Kenntnis dieses Krankheitsbilds erlaubt eine rechtzeitige Diagnosestellung und Intervention bei Komplikationen .	[ "Die", "kraniometaphysaere", "Dysplasie", "stellt", "eine", "seltene", "Unterform", "der", "sklerosierenden", "Skelettdysplasien", "mit", "klinischer", "Manifestation", "im", "fruehen", "Kleinkindesalter", "dar", ",", "die", "mit", "einer", "deutlichen", "Sklerose", "des", "gesamten", "Schaedels", "und", "mit", "einer", "Aufweitung", "der", "Metaphysen", "der", "langen", "Roehrenknochen", "einhergeht", ".", "Wir", "berichten", "ueber", "ein", "zum", "Zeitpunkt", "der", "Diagnosestellung", "18", "Monate", "altes", "maennliches", "Kleinkind", ",", "das", "mit", "zunehmendem", "Makrozephalus", ",", "chronischer", "Nasenatmungsbehinderung", "und", "einer", "Gesichtsdysmorphie", "(", "Hypertelorismus", ",", "breite", "Nasenwurzel", ",", "Zahnirregularitaeten", ")", "auffaellig", "wurde", ".", "Die", "Mutter", "des", "Patienten", "wies", "aehnliche", "Stigmata", "auf", ".", "Durch", "Roentgenaufnahmen", "von", "Schaedel", "und", "Femur", "bei", "Patient", "und", "Mutter", "konnte", "die", "Diagnose", "gestellt", "werden", ".", "Untersuchungen", "des", "Knochenstoffwechsels", "des", "betroffenen", "Kindes", "weisen", "auf", "eine", "Ueberaktivitaet", "der", "Osteoblasten", "hin", ".", "Eine", "Hirnnervenkompression", "als", "typische", "Komplikation", "des", "Krankheitsbilds", "konnte", "ausgeschlossen", "werden", ".", "Die", "krankheitsbedingte", "Nasenatmungsbehinderung", "machte", "jedoch", "eine", "Choanalerweiterung", "durch", "Resektion", "des", "posterioren", "Vomer", "notwendig", ".", "Die", "Kenntnis", "dieses", "Krankheitsbilds", "erlaubt", "eine", "rechtzeitige", "Diagnosestellung", "und", "Intervention", "bei", "Komplikationen", "." ]	[ "umlsterm" ]
Skelettdysplasien is an umlsterm, Sklerose is an umlsterm, Schaedels is an umlsterm, Diagnosestellung is an umlsterm, maennliches is an umlsterm, Kleinkind is an umlsterm, Hypertelorismus is an umlsterm, Zahnirregularitaeten is an umlsterm, Mutter is an umlsterm, Patienten is an umlsterm, Stigmata is an umlsterm, Roentgenaufnahmen is an umlsterm, Schaedel is an umlsterm, Femur is an umlsterm, Patient is an umlsterm, Mutter is an umlsterm, Diagnose is an umlsterm, Knochenstoffwechsels is an umlsterm, Kindes is an umlsterm, Osteoblasten is an umlsterm, Hirnnervenkompression is an umlsterm, Komplikation is an umlsterm, Vomer is an umlsterm, Diagnosestellung is an umlsterm, Komplikationen is an umlsterm	MonatsschriftKinderheilkunde.61441073.ger.abstr_task1	Sentence: Die kraniometaphysaere Dysplasie stellt eine seltene Unterform der sklerosierenden Skelettdysplasien mit klinischer Manifestation im fruehen Kleinkindesalter dar , die mit einer deutlichen Sklerose des gesamten Schaedels und mit einer Aufweitung der Metaphysen der langen Roehrenknochen einhergeht . Wir berichten ueber ein zum Zeitpunkt der Diagnosestellung 18 Monate altes maennliches Kleinkind , das mit zunehmendem Makrozephalus , chronischer Nasenatmungsbehinderung und einer Gesichtsdysmorphie ( Hypertelorismus , breite Nasenwurzel , Zahnirregularitaeten ) auffaellig wurde . Die Mutter des Patienten wies aehnliche Stigmata auf . Durch Roentgenaufnahmen von Schaedel und Femur bei Patient und Mutter konnte die Diagnose gestellt werden . Untersuchungen des Knochenstoffwechsels des betroffenen Kindes weisen auf eine Ueberaktivitaet der Osteoblasten hin . Eine Hirnnervenkompression als typische Komplikation des Krankheitsbilds konnte ausgeschlossen werden . Die krankheitsbedingte Nasenatmungsbehinderung machte jedoch eine Choanalerweiterung durch Resektion des posterioren Vomer notwendig . Die Kenntnis dieses Krankheitsbilds erlaubt eine rechtzeitige Diagnosestellung und Intervention bei Komplikationen . Instructions: please typing these entity words according to sentence: Skelettdysplasien, Sklerose, Schaedels, Diagnosestellung, maennliches, Kleinkind, Hypertelorismus, Zahnirregularitaeten, Mutter, Patienten, Stigmata, Roentgenaufnahmen, Schaedel, Femur, Patient, Mutter, Diagnose, Knochenstoffwechsels, Kindes, Osteoblasten, Hirnnervenkompression, Komplikation, Vomer, Diagnosestellung, Komplikationen Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O" ]	Die kraniometaphysaere Dysplasie stellt eine seltene Unterform der sklerosierenden Skelettdysplasien mit klinischer Manifestation im fruehen Kleinkindesalter dar , die mit einer deutlichen Sklerose des gesamten Schaedels und mit einer Aufweitung der Metaphysen der langen Roehrenknochen einhergeht . Wir berichten ueber ein zum Zeitpunkt der Diagnosestellung 18 Monate altes maennliches Kleinkind , das mit zunehmendem Makrozephalus , chronischer Nasenatmungsbehinderung und einer Gesichtsdysmorphie ( Hypertelorismus , breite Nasenwurzel , Zahnirregularitaeten ) auffaellig wurde . Die Mutter des Patienten wies aehnliche Stigmata auf . Durch Roentgenaufnahmen von Schaedel und Femur bei Patient und Mutter konnte die Diagnose gestellt werden . Untersuchungen des Knochenstoffwechsels des betroffenen Kindes weisen auf eine Ueberaktivitaet der Osteoblasten hin . Eine Hirnnervenkompression als typische Komplikation des Krankheitsbilds konnte ausgeschlossen werden . Die krankheitsbedingte Nasenatmungsbehinderung machte jedoch eine Choanalerweiterung durch Resektion des posterioren Vomer notwendig . Die Kenntnis dieses Krankheitsbilds erlaubt eine rechtzeitige Diagnosestellung und Intervention bei Komplikationen .	[ "Die", "kraniometaphysaere", "Dysplasie", "stellt", "eine", "seltene", "Unterform", "der", "sklerosierenden", "Skelettdysplasien", "mit", "klinischer", "Manifestation", "im", "fruehen", "Kleinkindesalter", "dar", ",", "die", "mit", "einer", "deutlichen", "Sklerose", "des", "gesamten", "Schaedels", "und", "mit", "einer", "Aufweitung", "der", "Metaphysen", "der", "langen", "Roehrenknochen", "einhergeht", ".", "Wir", "berichten", "ueber", "ein", "zum", "Zeitpunkt", "der", "Diagnosestellung", "18", "Monate", "altes", "maennliches", "Kleinkind", ",", "das", "mit", "zunehmendem", "Makrozephalus", ",", "chronischer", "Nasenatmungsbehinderung", "und", "einer", "Gesichtsdysmorphie", "(", "Hypertelorismus", ",", "breite", "Nasenwurzel", ",", "Zahnirregularitaeten", ")", "auffaellig", "wurde", ".", "Die", "Mutter", "des", "Patienten", "wies", "aehnliche", "Stigmata", "auf", ".", "Durch", "Roentgenaufnahmen", "von", "Schaedel", "und", "Femur", "bei", "Patient", "und", "Mutter", "konnte", "die", "Diagnose", "gestellt", "werden", ".", "Untersuchungen", "des", "Knochenstoffwechsels", "des", "betroffenen", "Kindes", "weisen", "auf", "eine", "Ueberaktivitaet", "der", "Osteoblasten", "hin", ".", "Eine", "Hirnnervenkompression", "als", "typische", "Komplikation", "des", "Krankheitsbilds", "konnte", "ausgeschlossen", "werden", ".", "Die", "krankheitsbedingte", "Nasenatmungsbehinderung", "machte", "jedoch", "eine", "Choanalerweiterung", "durch", "Resektion", "des", "posterioren", "Vomer", "notwendig", ".", "Die", "Kenntnis", "dieses", "Krankheitsbilds", "erlaubt", "eine", "rechtzeitige", "Diagnosestellung", "und", "Intervention", "bei", "Komplikationen", "." ]	[ "umlsterm" ]
Skelettdysplasien, Sklerose, Schaedels, Diagnosestellung, maennliches, Kleinkind, Hypertelorismus, Zahnirregularitaeten, Mutter, Patienten, Stigmata, Roentgenaufnahmen, Schaedel, Femur, Patient, Mutter, Diagnose, Knochenstoffwechsels, Kindes, Osteoblasten, Hirnnervenkompression, Komplikation, Vomer, Diagnosestellung, Komplikationen	MonatsschriftKinderheilkunde.61441073.ger.abstr_task2	Sentence: Die kraniometaphysaere Dysplasie stellt eine seltene Unterform der sklerosierenden Skelettdysplasien mit klinischer Manifestation im fruehen Kleinkindesalter dar , die mit einer deutlichen Sklerose des gesamten Schaedels und mit einer Aufweitung der Metaphysen der langen Roehrenknochen einhergeht . Wir berichten ueber ein zum Zeitpunkt der Diagnosestellung 18 Monate altes maennliches Kleinkind , das mit zunehmendem Makrozephalus , chronischer Nasenatmungsbehinderung und einer Gesichtsdysmorphie ( Hypertelorismus , breite Nasenwurzel , Zahnirregularitaeten ) auffaellig wurde . Die Mutter des Patienten wies aehnliche Stigmata auf . Durch Roentgenaufnahmen von Schaedel und Femur bei Patient und Mutter konnte die Diagnose gestellt werden . Untersuchungen des Knochenstoffwechsels des betroffenen Kindes weisen auf eine Ueberaktivitaet der Osteoblasten hin . Eine Hirnnervenkompression als typische Komplikation des Krankheitsbilds konnte ausgeschlossen werden . Die krankheitsbedingte Nasenatmungsbehinderung machte jedoch eine Choanalerweiterung durch Resektion des posterioren Vomer notwendig . Die Kenntnis dieses Krankheitsbilds erlaubt eine rechtzeitige Diagnosestellung und Intervention bei Komplikationen . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O" ]	Die kraniometaphysaere Dysplasie stellt eine seltene Unterform der sklerosierenden Skelettdysplasien mit klinischer Manifestation im fruehen Kleinkindesalter dar , die mit einer deutlichen Sklerose des gesamten Schaedels und mit einer Aufweitung der Metaphysen der langen Roehrenknochen einhergeht . Wir berichten ueber ein zum Zeitpunkt der Diagnosestellung 18 Monate altes maennliches Kleinkind , das mit zunehmendem Makrozephalus , chronischer Nasenatmungsbehinderung und einer Gesichtsdysmorphie ( Hypertelorismus , breite Nasenwurzel , Zahnirregularitaeten ) auffaellig wurde . Die Mutter des Patienten wies aehnliche Stigmata auf . Durch Roentgenaufnahmen von Schaedel und Femur bei Patient und Mutter konnte die Diagnose gestellt werden . Untersuchungen des Knochenstoffwechsels des betroffenen Kindes weisen auf eine Ueberaktivitaet der Osteoblasten hin . Eine Hirnnervenkompression als typische Komplikation des Krankheitsbilds konnte ausgeschlossen werden . Die krankheitsbedingte Nasenatmungsbehinderung machte jedoch eine Choanalerweiterung durch Resektion des posterioren Vomer notwendig . Die Kenntnis dieses Krankheitsbilds erlaubt eine rechtzeitige Diagnosestellung und Intervention bei Komplikationen .	[ "Die", "kraniometaphysaere", "Dysplasie", "stellt", "eine", "seltene", "Unterform", "der", "sklerosierenden", "Skelettdysplasien", "mit", "klinischer", "Manifestation", "im", "fruehen", "Kleinkindesalter", "dar", ",", "die", "mit", "einer", "deutlichen", "Sklerose", "des", "gesamten", "Schaedels", "und", "mit", "einer", "Aufweitung", "der", "Metaphysen", "der", "langen", "Roehrenknochen", "einhergeht", ".", "Wir", "berichten", "ueber", "ein", "zum", "Zeitpunkt", "der", "Diagnosestellung", "18", "Monate", "altes", "maennliches", "Kleinkind", ",", "das", "mit", "zunehmendem", "Makrozephalus", ",", "chronischer", "Nasenatmungsbehinderung", "und", "einer", "Gesichtsdysmorphie", "(", "Hypertelorismus", ",", "breite", "Nasenwurzel", ",", "Zahnirregularitaeten", ")", "auffaellig", "wurde", ".", "Die", "Mutter", "des", "Patienten", "wies", "aehnliche", "Stigmata", "auf", ".", "Durch", "Roentgenaufnahmen", "von", "Schaedel", "und", "Femur", "bei", "Patient", "und", "Mutter", "konnte", "die", "Diagnose", "gestellt", "werden", ".", "Untersuchungen", "des", "Knochenstoffwechsels", "des", "betroffenen", "Kindes", "weisen", "auf", "eine", "Ueberaktivitaet", "der", "Osteoblasten", "hin", ".", "Eine", "Hirnnervenkompression", "als", "typische", "Komplikation", "des", "Krankheitsbilds", "konnte", "ausgeschlossen", "werden", ".", "Die", "krankheitsbedingte", "Nasenatmungsbehinderung", "machte", "jedoch", "eine", "Choanalerweiterung", "durch", "Resektion", "des", "posterioren", "Vomer", "notwendig", ".", "Die", "Kenntnis", "dieses", "Krankheitsbilds", "erlaubt", "eine", "rechtzeitige", "Diagnosestellung", "und", "Intervention", "bei", "Komplikationen", "." ]	[ "umlsterm" ]
assay is an umlsterm, glucose is an umlsterm, ketones is an umlsterm, in urine is an umlsterm, test is an umlsterm, ketones is an umlsterm, autopsy is an umlsterm, hypothermia is an umlsterm, glucose is an umlsterm, urine is an umlsterm, urine is an umlsterm, acetone is an umlsterm, concentrations is an umlsterm, gas chromatography is an umlsterm, test is an umlsterm, ketones is an umlsterm, glucose is an umlsterm, in urine is an umlsterm, diagnosis is an umlsterm, death is an umlsterm, hyperthermia is an umlsterm	Rechtsmedizin.80080186.eng.abstr_task0	Sentence: The Keto-Diabur-Test 5000 ( Boehringer Mannheim ) is an assay for glucose and ketones in urine samples . Positive test results for ketones were obtained during the autopsy of three corpses who probably died following hypothermia , whereas the glucose levels in the urine samples were normal . In all of the three urine samples extremely high acetone concentrations of 140 , 1004 and 2703 mg/L were detected by headspace gas chromatography . A positive test for ketones using the Keto-Diabur-Test 5000 despite of normal glucose levels in urine can support the diagnosis of death due to hyperthermia . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]	The Keto-Diabur-Test 5000 ( Boehringer Mannheim ) is an assay for glucose and ketones in urine samples . Positive test results for ketones were obtained during the autopsy of three corpses who probably died following hypothermia , whereas the glucose levels in the urine samples were normal . In all of the three urine samples extremely high acetone concentrations of 140 , 1004 and 2703 mg/L were detected by headspace gas chromatography . A positive test for ketones using the Keto-Diabur-Test 5000 despite of normal glucose levels in urine can support the diagnosis of death due to hyperthermia .	[ "The", "Keto", "-", "Diabur", "-", "Test", "5000", "(", "Boehringer", "Mannheim", ")", "is", "an", "assay", "for", "glucose", "and", "ketones", "in", "urine", "samples", ".", "Positive", "test", "results", "for", "ketones", "were", "obtained", "during", "the", "autopsy", "of", "three", "corpses", "who", "probably", "died", "following", "hypothermia", ",", "whereas", "the", "glucose", "levels", "in", "the", "urine", "samples", "were", "normal", ".", "In", "all", "of", "the", "three", "urine", "samples", "extremely", "high", "acetone", "concentrations", "of", "140", ",", "1004", "and", "2703", "mg", "/", "L", "were", "detected", "by", "headspace", "gas", "chromatography", ".", "A", "positive", "test", "for", "ketones", "using", "the", "Keto", "-", "Diabur", "-", "Test", "5000", "despite", "of", "normal", "glucose", "levels", "in", "urine", "can", "support", "the", "diagnosis", "of", "death", "due", "to", "hyperthermia", "." ]	[ "umlsterm" ]
assay is an umlsterm, glucose is an umlsterm, ketones is an umlsterm, in urine is an umlsterm, test is an umlsterm, ketones is an umlsterm, autopsy is an umlsterm, hypothermia is an umlsterm, glucose is an umlsterm, urine is an umlsterm, urine is an umlsterm, acetone is an umlsterm, concentrations is an umlsterm, gas chromatography is an umlsterm, test is an umlsterm, ketones is an umlsterm, glucose is an umlsterm, in urine is an umlsterm, diagnosis is an umlsterm, death is an umlsterm, hyperthermia is an umlsterm	Rechtsmedizin.80080186.eng.abstr_task1	Sentence: The Keto-Diabur-Test 5000 ( Boehringer Mannheim ) is an assay for glucose and ketones in urine samples . Positive test results for ketones were obtained during the autopsy of three corpses who probably died following hypothermia , whereas the glucose levels in the urine samples were normal . In all of the three urine samples extremely high acetone concentrations of 140 , 1004 and 2703 mg/L were detected by headspace gas chromatography . A positive test for ketones using the Keto-Diabur-Test 5000 despite of normal glucose levels in urine can support the diagnosis of death due to hyperthermia . Instructions: please typing these entity words according to sentence: assay, glucose, ketones, in urine, test, ketones, autopsy, hypothermia, glucose, urine, urine, acetone, concentrations, gas chromatography, test, ketones, glucose, in urine, diagnosis, death, hyperthermia Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]	The Keto-Diabur-Test 5000 ( Boehringer Mannheim ) is an assay for glucose and ketones in urine samples . Positive test results for ketones were obtained during the autopsy of three corpses who probably died following hypothermia , whereas the glucose levels in the urine samples were normal . In all of the three urine samples extremely high acetone concentrations of 140 , 1004 and 2703 mg/L were detected by headspace gas chromatography . A positive test for ketones using the Keto-Diabur-Test 5000 despite of normal glucose levels in urine can support the diagnosis of death due to hyperthermia .	[ "The", "Keto", "-", "Diabur", "-", "Test", "5000", "(", "Boehringer", "Mannheim", ")", "is", "an", "assay", "for", "glucose", "and", "ketones", "in", "urine", "samples", ".", "Positive", "test", "results", "for", "ketones", "were", "obtained", "during", "the", "autopsy", "of", "three", "corpses", "who", "probably", "died", "following", "hypothermia", ",", "whereas", "the", "glucose", "levels", "in", "the", "urine", "samples", "were", "normal", ".", "In", "all", "of", "the", "three", "urine", "samples", "extremely", "high", "acetone", "concentrations", "of", "140", ",", "1004", "and", "2703", "mg", "/", "L", "were", "detected", "by", "headspace", "gas", "chromatography", ".", "A", "positive", "test", "for", "ketones", "using", "the", "Keto", "-", "Diabur", "-", "Test", "5000", "despite", "of", "normal", "glucose", "levels", "in", "urine", "can", "support", "the", "diagnosis", "of", "death", "due", "to", "hyperthermia", "." ]	[ "umlsterm" ]
assay, glucose, ketones, in urine, test, ketones, autopsy, hypothermia, glucose, urine, urine, acetone, concentrations, gas chromatography, test, ketones, glucose, in urine, diagnosis, death, hyperthermia	Rechtsmedizin.80080186.eng.abstr_task2	Sentence: The Keto-Diabur-Test 5000 ( Boehringer Mannheim ) is an assay for glucose and ketones in urine samples . Positive test results for ketones were obtained during the autopsy of three corpses who probably died following hypothermia , whereas the glucose levels in the urine samples were normal . In all of the three urine samples extremely high acetone concentrations of 140 , 1004 and 2703 mg/L were detected by headspace gas chromatography . A positive test for ketones using the Keto-Diabur-Test 5000 despite of normal glucose levels in urine can support the diagnosis of death due to hyperthermia . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]	The Keto-Diabur-Test 5000 ( Boehringer Mannheim ) is an assay for glucose and ketones in urine samples . Positive test results for ketones were obtained during the autopsy of three corpses who probably died following hypothermia , whereas the glucose levels in the urine samples were normal . In all of the three urine samples extremely high acetone concentrations of 140 , 1004 and 2703 mg/L were detected by headspace gas chromatography . A positive test for ketones using the Keto-Diabur-Test 5000 despite of normal glucose levels in urine can support the diagnosis of death due to hyperthermia .	[ "The", "Keto", "-", "Diabur", "-", "Test", "5000", "(", "Boehringer", "Mannheim", ")", "is", "an", "assay", "for", "glucose", "and", "ketones", "in", "urine", "samples", ".", "Positive", "test", "results", "for", "ketones", "were", "obtained", "during", "the", "autopsy", "of", "three", "corpses", "who", "probably", "died", "following", "hypothermia", ",", "whereas", "the", "glucose", "levels", "in", "the", "urine", "samples", "were", "normal", ".", "In", "all", "of", "the", "three", "urine", "samples", "extremely", "high", "acetone", "concentrations", "of", "140", ",", "1004", "and", "2703", "mg", "/", "L", "were", "detected", "by", "headspace", "gas", "chromatography", ".", "A", "positive", "test", "for", "ketones", "using", "the", "Keto", "-", "Diabur", "-", "Test", "5000", "despite", "of", "normal", "glucose", "levels", "in", "urine", "can", "support", "the", "diagnosis", "of", "death", "due", "to", "hyperthermia", "." ]	[ "umlsterm" ]
Purpura fulminans is an umlsterm, emergency is an umlsterm, internal medicine is an umlsterm, dermatology is an umlsterm, development is an umlsterm, skin is an umlsterm, necrosis is an umlsterm, disseminated intravascular coagulation is an umlsterm, consumption is an umlsterm, anticoagulant is an umlsterm, signs is an umlsterm, shock is an umlsterm, Purpura fulminans is an umlsterm, form is an umlsterm, protein C deficiency is an umlsterm, causes is an umlsterm, ecchymosis is an umlsterm, blebs is an umlsterm, necrosis is an umlsterm, erythrocytes is an umlsterm, thrombosis is an umlsterm, vessels is an umlsterm, Thrombocytopenia is an umlsterm, coagulation factors is an umlsterm, fibrinogen split products is an umlsterm, erythrocytes is an umlsterm, blood is an umlsterm, diagnosis is an umlsterm, therapy is an umlsterm, plasma is an umlsterm, heparin is an umlsterm, antibiotics is an umlsterm, surgical is an umlsterm, debridement is an umlsterm, disease is an umlsterm, mortality rate is an umlsterm, life is an umlsterm, patient is an umlsterm	DerHautarzt.60470541.eng.abstr_task0	Sentence: Purpura fulminans must be treated as an emergency in internal medicine and dermatology . Its characteristic features are the sudden development of progressively enlarging haemorrhagic skin necrosis , severe disseminated intravascular coagulation with consumption of anticoagulant factors , and signs of shock . Purpura fulminans can be classified into a neonatal form with inherited protein C deficiency and an acquired type for which multiple causes are known . Clinically it is characterized by massive ecchymosis with haemorrhagic blebs and acral necrosis . Histologically the lesions show widespread extravasation of erythrocytes and thrombosis of small vessels . Thrombocytopenia , decrease of coagulation factors , the presence of fibrinogen split products and fragmented erythrocytes in the blood smear help to confirm the diagnosis . The therapy includes fresh-frozen plasma , heparin , antibiotics and surgical debridement of necrotic areas . It is important to recognize the disease promptly because the mortality rate is about 30-40% and only quick intervention helps to save the life of the patient . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]	Purpura fulminans must be treated as an emergency in internal medicine and dermatology . Its characteristic features are the sudden development of progressively enlarging haemorrhagic skin necrosis , severe disseminated intravascular coagulation with consumption of anticoagulant factors , and signs of shock . Purpura fulminans can be classified into a neonatal form with inherited protein C deficiency and an acquired type for which multiple causes are known . Clinically it is characterized by massive ecchymosis with haemorrhagic blebs and acral necrosis . Histologically the lesions show widespread extravasation of erythrocytes and thrombosis of small vessels . Thrombocytopenia , decrease of coagulation factors , the presence of fibrinogen split products and fragmented erythrocytes in the blood smear help to confirm the diagnosis . The therapy includes fresh-frozen plasma , heparin , antibiotics and surgical debridement of necrotic areas . It is important to recognize the disease promptly because the mortality rate is about 30-40% and only quick intervention helps to save the life of the patient .	[ "Purpura", "fulminans", "must", "be", "treated", "as", "an", "emergency", "in", "internal", "medicine", "and", "dermatology", ".", "Its", "characteristic", "features", "are", "the", "sudden", "development", "of", "progressively", "enlarging", "haemorrhagic", "skin", "necrosis", ",", "severe", "disseminated", "intravascular", "coagulation", "with", "consumption", "of", "anticoagulant", "factors", ",", "and", "signs", "of", "shock", ".", "Purpura", "fulminans", "can", "be", "classified", "into", "a", "neonatal", "form", "with", "inherited", "protein", "C", "deficiency", "and", "an", "acquired", "type", "for", "which", "multiple", "causes", "are", "known", ".", "Clinically", "it", "is", "characterized", "by", "massive", "ecchymosis", "with", "haemorrhagic", "blebs", "and", "acral", "necrosis", ".", "Histologically", "the", "lesions", "show", "widespread", "extravasation", "of", "erythrocytes", "and", "thrombosis", "of", "small", "vessels", ".", "Thrombocytopenia", ",", "decrease", "of", "coagulation", "factors", ",", "the", "presence", "of", "fibrinogen", "split", "products", "and", "fragmented", "erythrocytes", "in", "the", "blood", "smear", "help", "to", "confirm", "the", "diagnosis", ".", "The", "therapy", "includes", "fresh", "-", "frozen", "plasma", ",", "heparin", ",", "antibiotics", "and", "surgical", "debridement", "of", "necrotic", "areas", ".", "It", "is", "important", "to", "recognize", "the", "disease", "promptly", "because", "the", "mortality", "rate", "is", "about", "30", "-", "40", "%", "and", "only", "quick", "intervention", "helps", "to", "save", "the", "life", "of", "the", "patient", "." ]	[ "umlsterm" ]
Purpura fulminans is an umlsterm, emergency is an umlsterm, internal medicine is an umlsterm, dermatology is an umlsterm, development is an umlsterm, skin is an umlsterm, necrosis is an umlsterm, disseminated intravascular coagulation is an umlsterm, consumption is an umlsterm, anticoagulant is an umlsterm, signs is an umlsterm, shock is an umlsterm, Purpura fulminans is an umlsterm, form is an umlsterm, protein C deficiency is an umlsterm, causes is an umlsterm, ecchymosis is an umlsterm, blebs is an umlsterm, necrosis is an umlsterm, erythrocytes is an umlsterm, thrombosis is an umlsterm, vessels is an umlsterm, Thrombocytopenia is an umlsterm, coagulation factors is an umlsterm, fibrinogen split products is an umlsterm, erythrocytes is an umlsterm, blood is an umlsterm, diagnosis is an umlsterm, therapy is an umlsterm, plasma is an umlsterm, heparin is an umlsterm, antibiotics is an umlsterm, surgical is an umlsterm, debridement is an umlsterm, disease is an umlsterm, mortality rate is an umlsterm, life is an umlsterm, patient is an umlsterm	DerHautarzt.60470541.eng.abstr_task1	Sentence: Purpura fulminans must be treated as an emergency in internal medicine and dermatology . Its characteristic features are the sudden development of progressively enlarging haemorrhagic skin necrosis , severe disseminated intravascular coagulation with consumption of anticoagulant factors , and signs of shock . Purpura fulminans can be classified into a neonatal form with inherited protein C deficiency and an acquired type for which multiple causes are known . Clinically it is characterized by massive ecchymosis with haemorrhagic blebs and acral necrosis . Histologically the lesions show widespread extravasation of erythrocytes and thrombosis of small vessels . Thrombocytopenia , decrease of coagulation factors , the presence of fibrinogen split products and fragmented erythrocytes in the blood smear help to confirm the diagnosis . The therapy includes fresh-frozen plasma , heparin , antibiotics and surgical debridement of necrotic areas . It is important to recognize the disease promptly because the mortality rate is about 30-40% and only quick intervention helps to save the life of the patient . Instructions: please typing these entity words according to sentence: Purpura fulminans, emergency, internal medicine, dermatology, development, skin, necrosis, disseminated intravascular coagulation, consumption, anticoagulant, signs, shock, Purpura fulminans, form, protein C deficiency, causes, ecchymosis, blebs, necrosis, erythrocytes, thrombosis, vessels, Thrombocytopenia, coagulation factors, fibrinogen split products, erythrocytes, blood, diagnosis, therapy, plasma, heparin, antibiotics, surgical, debridement, disease, mortality rate, life, patient Options: umlsterm	[ "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]	Purpura fulminans must be treated as an emergency in internal medicine and dermatology . Its characteristic features are the sudden development of progressively enlarging haemorrhagic skin necrosis , severe disseminated intravascular coagulation with consumption of anticoagulant factors , and signs of shock . Purpura fulminans can be classified into a neonatal form with inherited protein C deficiency and an acquired type for which multiple causes are known . Clinically it is characterized by massive ecchymosis with haemorrhagic blebs and acral necrosis . Histologically the lesions show widespread extravasation of erythrocytes and thrombosis of small vessels . Thrombocytopenia , decrease of coagulation factors , the presence of fibrinogen split products and fragmented erythrocytes in the blood smear help to confirm the diagnosis . The therapy includes fresh-frozen plasma , heparin , antibiotics and surgical debridement of necrotic areas . It is important to recognize the disease promptly because the mortality rate is about 30-40% and only quick intervention helps to save the life of the patient .	[ "Purpura", "fulminans", "must", "be", "treated", "as", "an", "emergency", "in", "internal", "medicine", "and", "dermatology", ".", "Its", "characteristic", "features", "are", "the", "sudden", "development", "of", "progressively", "enlarging", "haemorrhagic", "skin", "necrosis", ",", "severe", "disseminated", "intravascular", "coagulation", "with", "consumption", "of", "anticoagulant", "factors", ",", "and", "signs", "of", "shock", ".", "Purpura", "fulminans", "can", "be", "classified", "into", "a", "neonatal", "form", "with", "inherited", "protein", "C", "deficiency", "and", "an", "acquired", "type", "for", "which", "multiple", "causes", "are", "known", ".", "Clinically", "it", "is", "characterized", "by", "massive", "ecchymosis", "with", "haemorrhagic", "blebs", "and", "acral", "necrosis", ".", "Histologically", "the", "lesions", "show", "widespread", "extravasation", "of", "erythrocytes", "and", "thrombosis", "of", "small", "vessels", ".", "Thrombocytopenia", ",", "decrease", "of", "coagulation", "factors", ",", "the", "presence", "of", "fibrinogen", "split", "products", "and", "fragmented", "erythrocytes", "in", "the", "blood", "smear", "help", "to", "confirm", "the", "diagnosis", ".", "The", "therapy", "includes", "fresh", "-", "frozen", "plasma", ",", "heparin", ",", "antibiotics", "and", "surgical", "debridement", "of", "necrotic", "areas", ".", "It", "is", "important", "to", "recognize", "the", "disease", "promptly", "because", "the", "mortality", "rate", "is", "about", "30", "-", "40", "%", "and", "only", "quick", "intervention", "helps", "to", "save", "the", "life", "of", "the", "patient", "." ]	[ "umlsterm" ]
Purpura fulminans, emergency, internal medicine, dermatology, development, skin, necrosis, disseminated intravascular coagulation, consumption, anticoagulant, signs, shock, Purpura fulminans, form, protein C deficiency, causes, ecchymosis, blebs, necrosis, erythrocytes, thrombosis, vessels, Thrombocytopenia, coagulation factors, fibrinogen split products, erythrocytes, blood, diagnosis, therapy, plasma, heparin, antibiotics, surgical, debridement, disease, mortality rate, life, patient	DerHautarzt.60470541.eng.abstr_task2	Sentence: Purpura fulminans must be treated as an emergency in internal medicine and dermatology . Its characteristic features are the sudden development of progressively enlarging haemorrhagic skin necrosis , severe disseminated intravascular coagulation with consumption of anticoagulant factors , and signs of shock . Purpura fulminans can be classified into a neonatal form with inherited protein C deficiency and an acquired type for which multiple causes are known . Clinically it is characterized by massive ecchymosis with haemorrhagic blebs and acral necrosis . Histologically the lesions show widespread extravasation of erythrocytes and thrombosis of small vessels . Thrombocytopenia , decrease of coagulation factors , the presence of fibrinogen split products and fragmented erythrocytes in the blood smear help to confirm the diagnosis . The therapy includes fresh-frozen plasma , heparin , antibiotics and surgical debridement of necrotic areas . It is important to recognize the disease promptly because the mortality rate is about 30-40% and only quick intervention helps to save the life of the patient . Instructions: please extract entity words from the input sentence	[ "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]	Purpura fulminans must be treated as an emergency in internal medicine and dermatology . Its characteristic features are the sudden development of progressively enlarging haemorrhagic skin necrosis , severe disseminated intravascular coagulation with consumption of anticoagulant factors , and signs of shock . Purpura fulminans can be classified into a neonatal form with inherited protein C deficiency and an acquired type for which multiple causes are known . Clinically it is characterized by massive ecchymosis with haemorrhagic blebs and acral necrosis . Histologically the lesions show widespread extravasation of erythrocytes and thrombosis of small vessels . Thrombocytopenia , decrease of coagulation factors , the presence of fibrinogen split products and fragmented erythrocytes in the blood smear help to confirm the diagnosis . The therapy includes fresh-frozen plasma , heparin , antibiotics and surgical debridement of necrotic areas . It is important to recognize the disease promptly because the mortality rate is about 30-40% and only quick intervention helps to save the life of the patient .	[ "Purpura", "fulminans", "must", "be", "treated", "as", "an", "emergency", "in", "internal", "medicine", "and", "dermatology", ".", "Its", "characteristic", "features", "are", "the", "sudden", "development", "of", "progressively", "enlarging", "haemorrhagic", "skin", "necrosis", ",", "severe", "disseminated", "intravascular", "coagulation", "with", "consumption", "of", "anticoagulant", "factors", ",", "and", "signs", "of", "shock", ".", "Purpura", "fulminans", "can", "be", "classified", "into", "a", "neonatal", "form", "with", "inherited", "protein", "C", "deficiency", "and", "an", "acquired", "type", "for", "which", "multiple", "causes", "are", "known", ".", "Clinically", "it", "is", "characterized", "by", "massive", "ecchymosis", "with", "haemorrhagic", "blebs", "and", "acral", "necrosis", ".", "Histologically", "the", "lesions", "show", "widespread", "extravasation", "of", "erythrocytes", "and", "thrombosis", "of", "small", "vessels", ".", "Thrombocytopenia", ",", "decrease", "of", "coagulation", "factors", ",", "the", "presence", "of", "fibrinogen", "split", "products", "and", "fragmented", "erythrocytes", "in", "the", "blood", "smear", "help", "to", "confirm", "the", "diagnosis", ".", "The", "therapy", "includes", "fresh", "-", "frozen", "plasma", ",", "heparin", ",", "antibiotics", "and", "surgical", "debridement", "of", "necrotic", "areas", ".", "It", "is", "important", "to", "recognize", "the", "disease", "promptly", "because", "the", "mortality", "rate", "is", "about", "30", "-", "40", "%", "and", "only", "quick", "intervention", "helps", "to", "save", "the", "life", "of", "the", "patient", "." ]	[ "umlsterm" ]
nuclear T cell protein is a protein_family_or_group, TCF-1 is a protein_molecule, TCF-1 knock - out mice is an other_artificial_source	3589_task0	Sentence: Circumvention of tolerance for the nuclear T cell protein TCF-1 by immunization of TCF-1 knock-out mice. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: protein_family_or_group, other_artificial_source, protein_molecule	[ "O", "O", "O", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "B-protein_molecule", "O", "O", "O", "B-other_artificial_source", "I-other_artificial_source", "I-other_artificial_source", "I-other_artificial_source", "I-other_artificial_source", "O" ]	Circumvention of tolerance for the nuclear T cell protein TCF-1 by immunization of TCF-1 knock-out mice.	[ "Circumvention", "of", "tolerance", "for", "the", "nuclear", "T", "cell", "protein", "TCF-1", "by", "immunization", "of", "TCF-1", "knock", "-", "out", "mice", "." ]	[ "(AND protein_N/A protein_N/A)", "other_name", "protein_family_or_group", "cell_type", "cell_line", "other_artificial_source", "protein_molecule", "", "body_part", "multi_cell" ]
nuclear T cell protein is a protein_family_or_group, TCF-1 is a protein_molecule, TCF-1 knock - out mice is an other_artificial_source	3589_task1	Sentence: Circumvention of tolerance for the nuclear T cell protein TCF-1 by immunization of TCF-1 knock-out mice. Instructions: please typing these entity words according to sentence: nuclear T cell protein, TCF-1, TCF-1 knock - out mice Options: protein_family_or_group, other_artificial_source, protein_molecule	[ "O", "O", "O", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "B-protein_molecule", "O", "O", "O", "B-other_artificial_source", "I-other_artificial_source", "I-other_artificial_source", "I-other_artificial_source", "I-other_artificial_source", "O" ]	Circumvention of tolerance for the nuclear T cell protein TCF-1 by immunization of TCF-1 knock-out mice.	[ "Circumvention", "of", "tolerance", "for", "the", "nuclear", "T", "cell", "protein", "TCF-1", "by", "immunization", "of", "TCF-1", "knock", "-", "out", "mice", "." ]	[ "(AND protein_N/A protein_N/A)", "other_name", "protein_family_or_group", "cell_type", "cell_line", "other_artificial_source", "protein_molecule", "", "body_part", "multi_cell" ]
nuclear T cell protein, TCF-1, TCF-1 knock - out mice	3589_task2	Sentence: Circumvention of tolerance for the nuclear T cell protein TCF-1 by immunization of TCF-1 knock-out mice. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "B-protein_molecule", "O", "O", "O", "B-other_artificial_source", "I-other_artificial_source", "I-other_artificial_source", "I-other_artificial_source", "I-other_artificial_source", "O" ]	Circumvention of tolerance for the nuclear T cell protein TCF-1 by immunization of TCF-1 knock-out mice.	[ "Circumvention", "of", "tolerance", "for", "the", "nuclear", "T", "cell", "protein", "TCF-1", "by", "immunization", "of", "TCF-1", "knock", "-", "out", "mice", "." ]	[ "(AND protein_N/A protein_N/A)", "other_name", "protein_family_or_group", "cell_type", "cell_line", "other_artificial_source", "protein_molecule", "", "body_part", "multi_cell" ]
Glutathione peroxidases is a GENE-N, glutathione peroxidases is a GENE-N, GPxs is a GENE-N, cytosolic GPx is a GENE-N, cGPx is a GENE-N, GPx1 is a GENE-N, phospholipid hydroperoxide GPx is a GENE-N, PHGPX is a GENE-N, GPx4 is a GENE-N, plasma GPx is a GENE-N, pGPX is a GENE-N, GPx3 is a GENE-N, gastrointestinal GPx is a GENE-N, GI - GPx is a GENE-N, GPx2 is a GENE-N, humans , GPx6 is a GENE-Y, GPxs is a GENE-N, alcohols is a CHEMICAL, glutathione is a CHEMICAL, GSH is a CHEMICAL, GPxs is a GENE-N, cGPx is a GENE-Y, PHGPx is a GENE-N, NF - kappaB is a GENE-N, interleukin-1 is a GENE-N, leukotriene is a CHEMICAL, prostanoid is a CHEMICAL, COX-2 is a GENE-Y, GI - GPx is a GENE-N, GI - GPx is a GENE-N, Nrf2 is a GENE-Y, PHGPx is a GENE-N, cGPx is a GENE-Y, PHGPx is a GENE-N, GI - GPx is a GENE-N, GPxs is a GENE-N	2969_task0	Sentence: Glutathione peroxidases and redox-regulated transcription factors. Analysis of the selenoproteome identified five glutathione peroxidases (GPxs) in mammals: cytosolic GPx (cGPx, GPx1), phospholipid hydroperoxide GPx (PHGPX, GPx4), plasma GPx (pGPX, GPx3), gastrointestinal GPx (GI-GPx, GPx2) and, in humans, GPx6, which is restricted to the olfactory system. GPxs reduce hydroperoxides to the corresponding alcohols by means of glutathione (GSH). They have long been considered to only act as antioxidant enzymes. Increasing evidence, however, suggests that nature has not created redundant GPxs just to detoxify hydroperoxides. cGPx clearly acts as an antioxidant, as convincingly demonstrated in GPx1-knockout mice. PHGPx specifically interferes with NF-kappaB activation by interleukin-1, reduces leukotriene and prostanoid biosynthesis, prevents COX-2 expression, and is indispensable for sperm maturation and embryogenesis. GI-GPx, which is not exclusively expressed in the gastrointestinal system, is upregulated in colon and skin cancers and in certain cultured cancer cells. GI-GPx is a target for Nrf2, and thus is part of the adaptive response by itself, while PHGPx might prevent cancer by interfering with inflammatory pathways. In conclusion, cGPx, PHGPx and GI-GPx have distinct roles, particularly in cellular defence mechanisms. Redox sensing and redox regulation of metabolic events have become attractive paradigms to unravel the specific and in part still enigmatic roles of GPxs. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, GENE-N, CHEMICAL	[ "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "B-GENE-N", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "B-GENE-N", "O", "O", "B-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "B-GENE-N", "O", "O", "B-GENE-N", "I-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "B-GENE-N", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "B-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O" ]	Glutathione peroxidases and redox-regulated transcription factors. Analysis of the selenoproteome identified five glutathione peroxidases (GPxs) in mammals: cytosolic GPx (cGPx, GPx1), phospholipid hydroperoxide GPx (PHGPX, GPx4), plasma GPx (pGPX, GPx3), gastrointestinal GPx (GI-GPx, GPx2) and, in humans, GPx6, which is restricted to the olfactory system. GPxs reduce hydroperoxides to the corresponding alcohols by means of glutathione (GSH). They have long been considered to only act as antioxidant enzymes. Increasing evidence, however, suggests that nature has not created redundant GPxs just to detoxify hydroperoxides. cGPx clearly acts as an antioxidant, as convincingly demonstrated in GPx1-knockout mice. PHGPx specifically interferes with NF-kappaB activation by interleukin-1, reduces leukotriene and prostanoid biosynthesis, prevents COX-2 expression, and is indispensable for sperm maturation and embryogenesis. GI-GPx, which is not exclusively expressed in the gastrointestinal system, is upregulated in colon and skin cancers and in certain cultured cancer cells. GI-GPx is a target for Nrf2, and thus is part of the adaptive response by itself, while PHGPx might prevent cancer by interfering with inflammatory pathways. In conclusion, cGPx, PHGPx and GI-GPx have distinct roles, particularly in cellular defence mechanisms. Redox sensing and redox regulation of metabolic events have become attractive paradigms to unravel the specific and in part still enigmatic roles of GPxs.	[ "Glutathione", "peroxidases", "and", "redox", "-", "regulated", "transcription", "factors", ".", "\n", "Analysis", "of", "the", "selenoproteome", "identified", "five", "glutathione", "peroxidases", "(", "GPxs", ")", "in", "mammals", ":", "cytosolic", "GPx", "(", "cGPx", ",", "GPx1", ")", ",", "phospholipid", "hydroperoxide", "GPx", "(", "PHGPX", ",", "GPx4", ")", ",", "plasma", "GPx", "(", "pGPX", ",", "GPx3", ")", ",", "gastrointestinal", "GPx", "(", "GI", "-", "GPx", ",", "GPx2", ")", "and", ",", "in", "humans", ",", "GPx6", ",", "which", "is", "restricted", "to", "the", "olfactory", "system", ".", "GPxs", "reduce", "hydroperoxides", "to", "the", "corresponding", "alcohols", "by", "means", "of", "glutathione", "(", "GSH", ")", ".", "They", "have", "long", "been", "considered", "to", "only", "act", "as", "antioxidant", "enzymes", ".", "Increasing", "evidence", ",", "however", ",", "suggests", "that", "nature", "has", "not", "created", "redundant", "GPxs", "just", "to", "detoxify", "hydroperoxides", ".", "cGPx", "clearly", "acts", "as", "an", "antioxidant", ",", "as", "convincingly", "demonstrated", "in", "GPx1-knockout", "mice", ".", "PHGPx", "specifically", "interferes", "with", "NF", "-", "kappaB", "activation", "by", "interleukin-1", ",", "reduces", "leukotriene", "and", "prostanoid", "biosynthesis", ",", "prevents", "COX-2", "expression", ",", "and", "is", "indispensable", "for", "sperm", "maturation", "and", "embryogenesis", ".", "GI", "-", "GPx", ",", "which", "is", "not", "exclusively", "expressed", "in", "the", "gastrointestinal", "system", ",", "is", "upregulated", "in", "colon", "and", "skin", "cancers", "and", "in", "certain", "cultured", "cancer", "cells", ".", "GI", "-", "GPx", "is", "a", "target", "for", "Nrf2", ",", "and", "thus", "is", "part", "of", "the", "adaptive", "response", "by", "itself", ",", "while", "PHGPx", "might", "prevent", "cancer", "by", "interfering", "with", "inflammatory", "pathways", ".", "In", "conclusion", ",", "cGPx", ",", "PHGPx", "and", "GI", "-", "GPx", "have", "distinct", "roles", ",", "particularly", "in", "cellular", "defence", "mechanisms", ".", "Redox", "sensing", "and", "redox", "regulation", "of", "metabolic", "events", "have", "become", "attractive", "paradigms", "to", "unravel", "the", "specific", "and", "in", "part", "still", "enigmatic", "roles", "of", "GPxs", "." ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
Glutathione peroxidases is a GENE-N, glutathione peroxidases is a GENE-N, GPxs is a GENE-N, cytosolic GPx is a GENE-N, cGPx is a GENE-N, GPx1 is a GENE-N, phospholipid hydroperoxide GPx is a GENE-N, PHGPX is a GENE-N, GPx4 is a GENE-N, plasma GPx is a GENE-N, pGPX is a GENE-N, GPx3 is a GENE-N, gastrointestinal GPx is a GENE-N, GI - GPx is a GENE-N, GPx2 is a GENE-N, humans , GPx6 is a GENE-Y, GPxs is a GENE-N, alcohols is a CHEMICAL, glutathione is a CHEMICAL, GSH is a CHEMICAL, GPxs is a GENE-N, cGPx is a GENE-Y, PHGPx is a GENE-N, NF - kappaB is a GENE-N, interleukin-1 is a GENE-N, leukotriene is a CHEMICAL, prostanoid is a CHEMICAL, COX-2 is a GENE-Y, GI - GPx is a GENE-N, GI - GPx is a GENE-N, Nrf2 is a GENE-Y, PHGPx is a GENE-N, cGPx is a GENE-Y, PHGPx is a GENE-N, GI - GPx is a GENE-N, GPxs is a GENE-N	2969_task1	Sentence: Glutathione peroxidases and redox-regulated transcription factors. Analysis of the selenoproteome identified five glutathione peroxidases (GPxs) in mammals: cytosolic GPx (cGPx, GPx1), phospholipid hydroperoxide GPx (PHGPX, GPx4), plasma GPx (pGPX, GPx3), gastrointestinal GPx (GI-GPx, GPx2) and, in humans, GPx6, which is restricted to the olfactory system. GPxs reduce hydroperoxides to the corresponding alcohols by means of glutathione (GSH). They have long been considered to only act as antioxidant enzymes. Increasing evidence, however, suggests that nature has not created redundant GPxs just to detoxify hydroperoxides. cGPx clearly acts as an antioxidant, as convincingly demonstrated in GPx1-knockout mice. PHGPx specifically interferes with NF-kappaB activation by interleukin-1, reduces leukotriene and prostanoid biosynthesis, prevents COX-2 expression, and is indispensable for sperm maturation and embryogenesis. GI-GPx, which is not exclusively expressed in the gastrointestinal system, is upregulated in colon and skin cancers and in certain cultured cancer cells. GI-GPx is a target for Nrf2, and thus is part of the adaptive response by itself, while PHGPx might prevent cancer by interfering with inflammatory pathways. In conclusion, cGPx, PHGPx and GI-GPx have distinct roles, particularly in cellular defence mechanisms. Redox sensing and redox regulation of metabolic events have become attractive paradigms to unravel the specific and in part still enigmatic roles of GPxs. Instructions: please typing these entity words according to sentence: Glutathione peroxidases, glutathione peroxidases, GPxs, cytosolic GPx, cGPx, GPx1, phospholipid hydroperoxide GPx, PHGPX, GPx4, plasma GPx, pGPX, GPx3, gastrointestinal GPx, GI - GPx, GPx2, humans , GPx6, GPxs, alcohols, glutathione, GSH, GPxs, cGPx, PHGPx, NF - kappaB, interleukin-1, leukotriene, prostanoid, COX-2, GI - GPx, GI - GPx, Nrf2, PHGPx, cGPx, PHGPx, GI - GPx, GPxs Options: GENE-Y, GENE-N, CHEMICAL	[ "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "B-GENE-N", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "B-GENE-N", "O", "O", "B-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "B-GENE-N", "O", "O", "B-GENE-N", "I-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "B-GENE-N", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "B-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O" ]	Glutathione peroxidases and redox-regulated transcription factors. Analysis of the selenoproteome identified five glutathione peroxidases (GPxs) in mammals: cytosolic GPx (cGPx, GPx1), phospholipid hydroperoxide GPx (PHGPX, GPx4), plasma GPx (pGPX, GPx3), gastrointestinal GPx (GI-GPx, GPx2) and, in humans, GPx6, which is restricted to the olfactory system. GPxs reduce hydroperoxides to the corresponding alcohols by means of glutathione (GSH). They have long been considered to only act as antioxidant enzymes. Increasing evidence, however, suggests that nature has not created redundant GPxs just to detoxify hydroperoxides. cGPx clearly acts as an antioxidant, as convincingly demonstrated in GPx1-knockout mice. PHGPx specifically interferes with NF-kappaB activation by interleukin-1, reduces leukotriene and prostanoid biosynthesis, prevents COX-2 expression, and is indispensable for sperm maturation and embryogenesis. GI-GPx, which is not exclusively expressed in the gastrointestinal system, is upregulated in colon and skin cancers and in certain cultured cancer cells. GI-GPx is a target for Nrf2, and thus is part of the adaptive response by itself, while PHGPx might prevent cancer by interfering with inflammatory pathways. In conclusion, cGPx, PHGPx and GI-GPx have distinct roles, particularly in cellular defence mechanisms. Redox sensing and redox regulation of metabolic events have become attractive paradigms to unravel the specific and in part still enigmatic roles of GPxs.	[ "Glutathione", "peroxidases", "and", "redox", "-", "regulated", "transcription", "factors", ".", "\n", "Analysis", "of", "the", "selenoproteome", "identified", "five", "glutathione", "peroxidases", "(", "GPxs", ")", "in", "mammals", ":", "cytosolic", "GPx", "(", "cGPx", ",", "GPx1", ")", ",", "phospholipid", "hydroperoxide", "GPx", "(", "PHGPX", ",", "GPx4", ")", ",", "plasma", "GPx", "(", "pGPX", ",", "GPx3", ")", ",", "gastrointestinal", "GPx", "(", "GI", "-", "GPx", ",", "GPx2", ")", "and", ",", "in", "humans", ",", "GPx6", ",", "which", "is", "restricted", "to", "the", "olfactory", "system", ".", "GPxs", "reduce", "hydroperoxides", "to", "the", "corresponding", "alcohols", "by", "means", "of", "glutathione", "(", "GSH", ")", ".", "They", "have", "long", "been", "considered", "to", "only", "act", "as", "antioxidant", "enzymes", ".", "Increasing", "evidence", ",", "however", ",", "suggests", "that", "nature", "has", "not", "created", "redundant", "GPxs", "just", "to", "detoxify", "hydroperoxides", ".", "cGPx", "clearly", "acts", "as", "an", "antioxidant", ",", "as", "convincingly", "demonstrated", "in", "GPx1-knockout", "mice", ".", "PHGPx", "specifically", "interferes", "with", "NF", "-", "kappaB", "activation", "by", "interleukin-1", ",", "reduces", "leukotriene", "and", "prostanoid", "biosynthesis", ",", "prevents", "COX-2", "expression", ",", "and", "is", "indispensable", "for", "sperm", "maturation", "and", "embryogenesis", ".", "GI", "-", "GPx", ",", "which", "is", "not", "exclusively", "expressed", "in", "the", "gastrointestinal", "system", ",", "is", "upregulated", "in", "colon", "and", "skin", "cancers", "and", "in", "certain", "cultured", "cancer", "cells", ".", "GI", "-", "GPx", "is", "a", "target", "for", "Nrf2", ",", "and", "thus", "is", "part", "of", "the", "adaptive", "response", "by", "itself", ",", "while", "PHGPx", "might", "prevent", "cancer", "by", "interfering", "with", "inflammatory", "pathways", ".", "In", "conclusion", ",", "cGPx", ",", "PHGPx", "and", "GI", "-", "GPx", "have", "distinct", "roles", ",", "particularly", "in", "cellular", "defence", "mechanisms", ".", "Redox", "sensing", "and", "redox", "regulation", "of", "metabolic", "events", "have", "become", "attractive", "paradigms", "to", "unravel", "the", "specific", "and", "in", "part", "still", "enigmatic", "roles", "of", "GPxs", "." ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
Glutathione peroxidases, glutathione peroxidases, GPxs, cytosolic GPx, cGPx, GPx1, phospholipid hydroperoxide GPx, PHGPX, GPx4, plasma GPx, pGPX, GPx3, gastrointestinal GPx, GI - GPx, GPx2, humans , GPx6, GPxs, alcohols, glutathione, GSH, GPxs, cGPx, PHGPx, NF - kappaB, interleukin-1, leukotriene, prostanoid, COX-2, GI - GPx, GI - GPx, Nrf2, PHGPx, cGPx, PHGPx, GI - GPx, GPxs	2969_task2	Sentence: Glutathione peroxidases and redox-regulated transcription factors. Analysis of the selenoproteome identified five glutathione peroxidases (GPxs) in mammals: cytosolic GPx (cGPx, GPx1), phospholipid hydroperoxide GPx (PHGPX, GPx4), plasma GPx (pGPX, GPx3), gastrointestinal GPx (GI-GPx, GPx2) and, in humans, GPx6, which is restricted to the olfactory system. GPxs reduce hydroperoxides to the corresponding alcohols by means of glutathione (GSH). They have long been considered to only act as antioxidant enzymes. Increasing evidence, however, suggests that nature has not created redundant GPxs just to detoxify hydroperoxides. cGPx clearly acts as an antioxidant, as convincingly demonstrated in GPx1-knockout mice. PHGPx specifically interferes with NF-kappaB activation by interleukin-1, reduces leukotriene and prostanoid biosynthesis, prevents COX-2 expression, and is indispensable for sperm maturation and embryogenesis. GI-GPx, which is not exclusively expressed in the gastrointestinal system, is upregulated in colon and skin cancers and in certain cultured cancer cells. GI-GPx is a target for Nrf2, and thus is part of the adaptive response by itself, while PHGPx might prevent cancer by interfering with inflammatory pathways. In conclusion, cGPx, PHGPx and GI-GPx have distinct roles, particularly in cellular defence mechanisms. Redox sensing and redox regulation of metabolic events have become attractive paradigms to unravel the specific and in part still enigmatic roles of GPxs. Instructions: please extract entity words from the input sentence	[ "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "B-GENE-N", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "B-GENE-N", "O", "O", "B-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "B-GENE-N", "O", "O", "B-GENE-N", "I-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "B-GENE-N", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "B-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O" ]	Glutathione peroxidases and redox-regulated transcription factors. Analysis of the selenoproteome identified five glutathione peroxidases (GPxs) in mammals: cytosolic GPx (cGPx, GPx1), phospholipid hydroperoxide GPx (PHGPX, GPx4), plasma GPx (pGPX, GPx3), gastrointestinal GPx (GI-GPx, GPx2) and, in humans, GPx6, which is restricted to the olfactory system. GPxs reduce hydroperoxides to the corresponding alcohols by means of glutathione (GSH). They have long been considered to only act as antioxidant enzymes. Increasing evidence, however, suggests that nature has not created redundant GPxs just to detoxify hydroperoxides. cGPx clearly acts as an antioxidant, as convincingly demonstrated in GPx1-knockout mice. PHGPx specifically interferes with NF-kappaB activation by interleukin-1, reduces leukotriene and prostanoid biosynthesis, prevents COX-2 expression, and is indispensable for sperm maturation and embryogenesis. GI-GPx, which is not exclusively expressed in the gastrointestinal system, is upregulated in colon and skin cancers and in certain cultured cancer cells. GI-GPx is a target for Nrf2, and thus is part of the adaptive response by itself, while PHGPx might prevent cancer by interfering with inflammatory pathways. In conclusion, cGPx, PHGPx and GI-GPx have distinct roles, particularly in cellular defence mechanisms. Redox sensing and redox regulation of metabolic events have become attractive paradigms to unravel the specific and in part still enigmatic roles of GPxs.	[ "Glutathione", "peroxidases", "and", "redox", "-", "regulated", "transcription", "factors", ".", "\n", "Analysis", "of", "the", "selenoproteome", "identified", "five", "glutathione", "peroxidases", "(", "GPxs", ")", "in", "mammals", ":", "cytosolic", "GPx", "(", "cGPx", ",", "GPx1", ")", ",", "phospholipid", "hydroperoxide", "GPx", "(", "PHGPX", ",", "GPx4", ")", ",", "plasma", "GPx", "(", "pGPX", ",", "GPx3", ")", ",", "gastrointestinal", "GPx", "(", "GI", "-", "GPx", ",", "GPx2", ")", "and", ",", "in", "humans", ",", "GPx6", ",", "which", "is", "restricted", "to", "the", "olfactory", "system", ".", "GPxs", "reduce", "hydroperoxides", "to", "the", "corresponding", "alcohols", "by", "means", "of", "glutathione", "(", "GSH", ")", ".", "They", "have", "long", "been", "considered", "to", "only", "act", "as", "antioxidant", "enzymes", ".", "Increasing", "evidence", ",", "however", ",", "suggests", "that", "nature", "has", "not", "created", "redundant", "GPxs", "just", "to", "detoxify", "hydroperoxides", ".", "cGPx", "clearly", "acts", "as", "an", "antioxidant", ",", "as", "convincingly", "demonstrated", "in", "GPx1-knockout", "mice", ".", "PHGPx", "specifically", "interferes", "with", "NF", "-", "kappaB", "activation", "by", "interleukin-1", ",", "reduces", "leukotriene", "and", "prostanoid", "biosynthesis", ",", "prevents", "COX-2", "expression", ",", "and", "is", "indispensable", "for", "sperm", "maturation", "and", "embryogenesis", ".", "GI", "-", "GPx", ",", "which", "is", "not", "exclusively", "expressed", "in", "the", "gastrointestinal", "system", ",", "is", "upregulated", "in", "colon", "and", "skin", "cancers", "and", "in", "certain", "cultured", "cancer", "cells", ".", "GI", "-", "GPx", "is", "a", "target", "for", "Nrf2", ",", "and", "thus", "is", "part", "of", "the", "adaptive", "response", "by", "itself", ",", "while", "PHGPx", "might", "prevent", "cancer", "by", "interfering", "with", "inflammatory", "pathways", ".", "In", "conclusion", ",", "cGPx", ",", "PHGPx", "and", "GI", "-", "GPx", "have", "distinct", "roles", ",", "particularly", "in", "cellular", "defence", "mechanisms", ".", "Redox", "sensing", "and", "redox", "regulation", "of", "metabolic", "events", "have", "become", "attractive", "paradigms", "to", "unravel", "the", "specific", "and", "in", "part", "still", "enigmatic", "roles", "of", "GPxs", "." ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
Suizide is an umlsterm, Suizide is an umlsterm, Suizid is an umlsterm, Sterbehilfeorganisation is an umlsterm, Analyse is an umlsterm, Sterbehilfeorganisation is an umlsterm, Kranken is an umlsterm, Suizid is an umlsterm	DerNervenarzt.90701014.ger.abstr_task0	Sentence: In der Region Basel wurden zwischen 1992 und 1997 43 begleitete Suizide erfasst . Das sind rund 8% aller Suizide in der Region . Die Beihilfe zum Suizid erfolgte durch die Sterbehilfeorganisation Exit . Bei 6 Suizidentinnen und Suizidenten ( 14% ) war eine psychiatrische Vorgeschichte bekannt . Bei 4 von ihnen bestanden gleichzeitig schwere koerperliche Erkrankungen . Die kasuistische Analyse prueft die Frage , ob und unter welchen Bedingungen die Sterbehilfeorganisation Exit bei psychisch Kranken Beihilfe zum Suizid leistet und welche Probleme daraus erwachsen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]	In der Region Basel wurden zwischen 1992 und 1997 43 begleitete Suizide erfasst . Das sind rund 8% aller Suizide in der Region . Die Beihilfe zum Suizid erfolgte durch die Sterbehilfeorganisation Exit . Bei 6 Suizidentinnen und Suizidenten ( 14% ) war eine psychiatrische Vorgeschichte bekannt . Bei 4 von ihnen bestanden gleichzeitig schwere koerperliche Erkrankungen . Die kasuistische Analyse prueft die Frage , ob und unter welchen Bedingungen die Sterbehilfeorganisation Exit bei psychisch Kranken Beihilfe zum Suizid leistet und welche Probleme daraus erwachsen .	[ "In", "der", "Region", "Basel", "wurden", "zwischen", "1992", "und", "1997", "43", "begleitete", "Suizide", "erfasst", ".", "Das", "sind", "rund", "8", "%", "aller", "Suizide", "in", "der", "Region", ".", "Die", "Beihilfe", "zum", "Suizid", "erfolgte", "durch", "die", "Sterbehilfeorganisation", "Exit", ".", "Bei", "6", "Suizidentinnen", "und", "Suizidenten", "(", "14", "%", ")", "war", "eine", "psychiatrische", "Vorgeschichte", "bekannt", ".", "Bei", "4", "von", "ihnen", "bestanden", "gleichzeitig", "schwere", "koerperliche", "Erkrankungen", ".", "Die", "kasuistische", "Analyse", "prueft", "die", "Frage", ",", "ob", "und", "unter", "welchen", "Bedingungen", "die", "Sterbehilfeorganisation", "Exit", "bei", "psychisch", "Kranken", "Beihilfe", "zum", "Suizid", "leistet", "und", "welche", "Probleme", "daraus", "erwachsen", "." ]	[ "umlsterm" ]
Suizide is an umlsterm, Suizide is an umlsterm, Suizid is an umlsterm, Sterbehilfeorganisation is an umlsterm, Analyse is an umlsterm, Sterbehilfeorganisation is an umlsterm, Kranken is an umlsterm, Suizid is an umlsterm	DerNervenarzt.90701014.ger.abstr_task1	Sentence: In der Region Basel wurden zwischen 1992 und 1997 43 begleitete Suizide erfasst . Das sind rund 8% aller Suizide in der Region . Die Beihilfe zum Suizid erfolgte durch die Sterbehilfeorganisation Exit . Bei 6 Suizidentinnen und Suizidenten ( 14% ) war eine psychiatrische Vorgeschichte bekannt . Bei 4 von ihnen bestanden gleichzeitig schwere koerperliche Erkrankungen . Die kasuistische Analyse prueft die Frage , ob und unter welchen Bedingungen die Sterbehilfeorganisation Exit bei psychisch Kranken Beihilfe zum Suizid leistet und welche Probleme daraus erwachsen . Instructions: please typing these entity words according to sentence: Suizide, Suizide, Suizid, Sterbehilfeorganisation, Analyse, Sterbehilfeorganisation, Kranken, Suizid Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]	In der Region Basel wurden zwischen 1992 und 1997 43 begleitete Suizide erfasst . Das sind rund 8% aller Suizide in der Region . Die Beihilfe zum Suizid erfolgte durch die Sterbehilfeorganisation Exit . Bei 6 Suizidentinnen und Suizidenten ( 14% ) war eine psychiatrische Vorgeschichte bekannt . Bei 4 von ihnen bestanden gleichzeitig schwere koerperliche Erkrankungen . Die kasuistische Analyse prueft die Frage , ob und unter welchen Bedingungen die Sterbehilfeorganisation Exit bei psychisch Kranken Beihilfe zum Suizid leistet und welche Probleme daraus erwachsen .	[ "In", "der", "Region", "Basel", "wurden", "zwischen", "1992", "und", "1997", "43", "begleitete", "Suizide", "erfasst", ".", "Das", "sind", "rund", "8", "%", "aller", "Suizide", "in", "der", "Region", ".", "Die", "Beihilfe", "zum", "Suizid", "erfolgte", "durch", "die", "Sterbehilfeorganisation", "Exit", ".", "Bei", "6", "Suizidentinnen", "und", "Suizidenten", "(", "14", "%", ")", "war", "eine", "psychiatrische", "Vorgeschichte", "bekannt", ".", "Bei", "4", "von", "ihnen", "bestanden", "gleichzeitig", "schwere", "koerperliche", "Erkrankungen", ".", "Die", "kasuistische", "Analyse", "prueft", "die", "Frage", ",", "ob", "und", "unter", "welchen", "Bedingungen", "die", "Sterbehilfeorganisation", "Exit", "bei", "psychisch", "Kranken", "Beihilfe", "zum", "Suizid", "leistet", "und", "welche", "Probleme", "daraus", "erwachsen", "." ]	[ "umlsterm" ]
Suizide, Suizide, Suizid, Sterbehilfeorganisation, Analyse, Sterbehilfeorganisation, Kranken, Suizid	DerNervenarzt.90701014.ger.abstr_task2	Sentence: In der Region Basel wurden zwischen 1992 und 1997 43 begleitete Suizide erfasst . Das sind rund 8% aller Suizide in der Region . Die Beihilfe zum Suizid erfolgte durch die Sterbehilfeorganisation Exit . Bei 6 Suizidentinnen und Suizidenten ( 14% ) war eine psychiatrische Vorgeschichte bekannt . Bei 4 von ihnen bestanden gleichzeitig schwere koerperliche Erkrankungen . Die kasuistische Analyse prueft die Frage , ob und unter welchen Bedingungen die Sterbehilfeorganisation Exit bei psychisch Kranken Beihilfe zum Suizid leistet und welche Probleme daraus erwachsen . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]	In der Region Basel wurden zwischen 1992 und 1997 43 begleitete Suizide erfasst . Das sind rund 8% aller Suizide in der Region . Die Beihilfe zum Suizid erfolgte durch die Sterbehilfeorganisation Exit . Bei 6 Suizidentinnen und Suizidenten ( 14% ) war eine psychiatrische Vorgeschichte bekannt . Bei 4 von ihnen bestanden gleichzeitig schwere koerperliche Erkrankungen . Die kasuistische Analyse prueft die Frage , ob und unter welchen Bedingungen die Sterbehilfeorganisation Exit bei psychisch Kranken Beihilfe zum Suizid leistet und welche Probleme daraus erwachsen .	[ "In", "der", "Region", "Basel", "wurden", "zwischen", "1992", "und", "1997", "43", "begleitete", "Suizide", "erfasst", ".", "Das", "sind", "rund", "8", "%", "aller", "Suizide", "in", "der", "Region", ".", "Die", "Beihilfe", "zum", "Suizid", "erfolgte", "durch", "die", "Sterbehilfeorganisation", "Exit", ".", "Bei", "6", "Suizidentinnen", "und", "Suizidenten", "(", "14", "%", ")", "war", "eine", "psychiatrische", "Vorgeschichte", "bekannt", ".", "Bei", "4", "von", "ihnen", "bestanden", "gleichzeitig", "schwere", "koerperliche", "Erkrankungen", ".", "Die", "kasuistische", "Analyse", "prueft", "die", "Frage", ",", "ob", "und", "unter", "welchen", "Bedingungen", "die", "Sterbehilfeorganisation", "Exit", "bei", "psychisch", "Kranken", "Beihilfe", "zum", "Suizid", "leistet", "und", "welche", "Probleme", "daraus", "erwachsen", "." ]	[ "umlsterm" ]
6-OHDA is a CHEMICAL, Nrf2 is a GENE-Y, NF - κB is a GENE-N	23274087_task0	Sentence: 6-OHDA-induced apoptosis and mitochondrial dysfunction are mediated by early modulation of intracellular signals and interaction of Nrf2 and NF-κB factors. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N, GENE-Y, CHEMICAL	[ "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O" ]	6-OHDA-induced apoptosis and mitochondrial dysfunction are mediated by early modulation of intracellular signals and interaction of Nrf2 and NF-κB factors.	[ "6-OHDA", "-", "induced", "apoptosis", "and", "mitochondrial", "dysfunction", "are", "mediated", "by", "early", "modulation", "of", "intracellular", "signals", "and", "interaction", "of", "Nrf2", "and", "NF", "-", "κB", "factors", "." ]	[ "GENE-Y", "GENE-N", "CHEMICAL" ]
6-OHDA is a CHEMICAL, Nrf2 is a GENE-Y, NF - κB is a GENE-N	23274087_task1	Sentence: 6-OHDA-induced apoptosis and mitochondrial dysfunction are mediated by early modulation of intracellular signals and interaction of Nrf2 and NF-κB factors. Instructions: please typing these entity words according to sentence: 6-OHDA, Nrf2, NF - κB Options: GENE-N, GENE-Y, CHEMICAL	[ "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O" ]	6-OHDA-induced apoptosis and mitochondrial dysfunction are mediated by early modulation of intracellular signals and interaction of Nrf2 and NF-κB factors.	[ "6-OHDA", "-", "induced", "apoptosis", "and", "mitochondrial", "dysfunction", "are", "mediated", "by", "early", "modulation", "of", "intracellular", "signals", "and", "interaction", "of", "Nrf2", "and", "NF", "-", "κB", "factors", "." ]	[ "GENE-Y", "GENE-N", "CHEMICAL" ]
6-OHDA, Nrf2, NF - κB	23274087_task2	Sentence: 6-OHDA-induced apoptosis and mitochondrial dysfunction are mediated by early modulation of intracellular signals and interaction of Nrf2 and NF-κB factors. Instructions: please extract entity words from the input sentence	[ "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O" ]	6-OHDA-induced apoptosis and mitochondrial dysfunction are mediated by early modulation of intracellular signals and interaction of Nrf2 and NF-κB factors.	[ "6-OHDA", "-", "induced", "apoptosis", "and", "mitochondrial", "dysfunction", "are", "mediated", "by", "early", "modulation", "of", "intracellular", "signals", "and", "interaction", "of", "Nrf2", "and", "NF", "-", "κB", "factors", "." ]	[ "GENE-Y", "GENE-N", "CHEMICAL" ]
family is an umlsterm, signs is an umlsterm, syndrome is an umlsterm, hearing loss is an umlsterm, leukocyte is an umlsterm, inclusion bodies is an umlsterm, eye anomalies is an umlsterm, nephritis is an umlsterm	HNO.00480616.eng.abstr_task0	Sentence: In this article , we report on a family in which five examined members showed clinical signs of Fechtner syndrome , a condition which consists of hearing loss ( 49% ) , macrothrombocytopenia ( 100% ) , leukocyte inclusion bodies ( 100% ) , eye anomalies ( 54.3% ) , and nephritis ( 38.7% ) . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	In this article , we report on a family in which five examined members showed clinical signs of Fechtner syndrome , a condition which consists of hearing loss ( 49% ) , macrothrombocytopenia ( 100% ) , leukocyte inclusion bodies ( 100% ) , eye anomalies ( 54.3% ) , and nephritis ( 38.7% ) .	[ "In", "this", "article", ",", "we", "report", "on", "a", "family", "in", "which", "five", "examined", "members", "showed", "clinical", "signs", "of", "Fechtner", "syndrome", ",", "a", "condition", "which", "consists", "of", "hearing", "loss", "(", "49", "%", ")", ",", "macrothrombocytopenia", "(", "100", "%", ")", ",", "leukocyte", "inclusion", "bodies", "(", "100", "%", ")", ",", "eye", "anomalies", "(", "54.3", "%", ")", ",", "and", "nephritis", "(", "38.7", "%", ")", "." ]	[ "umlsterm" ]
family is an umlsterm, signs is an umlsterm, syndrome is an umlsterm, hearing loss is an umlsterm, leukocyte is an umlsterm, inclusion bodies is an umlsterm, eye anomalies is an umlsterm, nephritis is an umlsterm	HNO.00480616.eng.abstr_task1	Sentence: In this article , we report on a family in which five examined members showed clinical signs of Fechtner syndrome , a condition which consists of hearing loss ( 49% ) , macrothrombocytopenia ( 100% ) , leukocyte inclusion bodies ( 100% ) , eye anomalies ( 54.3% ) , and nephritis ( 38.7% ) . Instructions: please typing these entity words according to sentence: family, signs, syndrome, hearing loss, leukocyte, inclusion bodies, eye anomalies, nephritis Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	In this article , we report on a family in which five examined members showed clinical signs of Fechtner syndrome , a condition which consists of hearing loss ( 49% ) , macrothrombocytopenia ( 100% ) , leukocyte inclusion bodies ( 100% ) , eye anomalies ( 54.3% ) , and nephritis ( 38.7% ) .	[ "In", "this", "article", ",", "we", "report", "on", "a", "family", "in", "which", "five", "examined", "members", "showed", "clinical", "signs", "of", "Fechtner", "syndrome", ",", "a", "condition", "which", "consists", "of", "hearing", "loss", "(", "49", "%", ")", ",", "macrothrombocytopenia", "(", "100", "%", ")", ",", "leukocyte", "inclusion", "bodies", "(", "100", "%", ")", ",", "eye", "anomalies", "(", "54.3", "%", ")", ",", "and", "nephritis", "(", "38.7", "%", ")", "." ]	[ "umlsterm" ]
family, signs, syndrome, hearing loss, leukocyte, inclusion bodies, eye anomalies, nephritis	HNO.00480616.eng.abstr_task2	Sentence: In this article , we report on a family in which five examined members showed clinical signs of Fechtner syndrome , a condition which consists of hearing loss ( 49% ) , macrothrombocytopenia ( 100% ) , leukocyte inclusion bodies ( 100% ) , eye anomalies ( 54.3% ) , and nephritis ( 38.7% ) . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	In this article , we report on a family in which five examined members showed clinical signs of Fechtner syndrome , a condition which consists of hearing loss ( 49% ) , macrothrombocytopenia ( 100% ) , leukocyte inclusion bodies ( 100% ) , eye anomalies ( 54.3% ) , and nephritis ( 38.7% ) .	[ "In", "this", "article", ",", "we", "report", "on", "a", "family", "in", "which", "five", "examined", "members", "showed", "clinical", "signs", "of", "Fechtner", "syndrome", ",", "a", "condition", "which", "consists", "of", "hearing", "loss", "(", "49", "%", ")", ",", "macrothrombocytopenia", "(", "100", "%", ")", ",", "leukocyte", "inclusion", "bodies", "(", "100", "%", ")", ",", "eye", "anomalies", "(", "54.3", "%", ")", ",", "and", "nephritis", "(", "38.7", "%", ")", "." ]	[ "umlsterm" ]
phrenic nerve is a Participant_Condition, pneumonectomy is a Intervention_Surgical, 10 is a Participant_Sample-size, lung cancer is a Participant_Condition, ultrasonographic is a Intervention_Other	61358_task0	Sentence: Effect of phrenic nerve palsy on early postoperative lung function after pneumonectomy : a prospective study . BACKGROUND The issue of phrenic nerve preservation during pneumonectomy is still an unanswered question . So far , its direct effect on immediate postoperative pulmonary lung function has never been evaluated in a prospective trial . METHODS We conducted a prospective crossover study including 10 patients undergoing pneumonectomy for lung cancer between July 2011 and July 2012 . After written informed consent , all consecutive patients who agreed to take part in the study and in whom preservation of the phrenic nerve during operation was possible , were included in the study . Upon completion of lung resection , a catheter was placed in the proximal paraphrenic tissue on the pericardial surface . After an initial phase of recovery of 5 days all patients underwent ultrasonographic assessment of diaphragmatic motion followed by lung function testing with and without induced phrenic nerve palsy . The controlled , temporary paralysis of the ipsilateral hemidiaphragm was achieved by local administration of lidocaine 1 % at a rate of 3 mL/h ( 30 mg/h ) via the above-mentioned catheter . RESULTS Temporary phrenic nerve palsy was accomplished in all but 1 patient with suspected catheter dislocation . Spirometry showed a significant decrease in dynamic lung volumes ( forced expiratory volume in 1 second and forced vital capacity ; p < 0.05 ) with the paralyzed hemidiaphragm . Blood oxygen saturation levels did not change significantly . CONCLUSIONS Our results show that phrenic nerve palsy causes a significant impairment of dynamic lung volumes during the early postoperative period after pneumonectomy . Therefore , in these already compromised patients , intraoperative phrenic nerve injury should be avoided whenever possible . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Other, Intervention_Surgical, Participant_Condition, Participant_Sample-size	[ "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Surgical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Effect of phrenic nerve palsy on early postoperative lung function after pneumonectomy : a prospective study . BACKGROUND The issue of phrenic nerve preservation during pneumonectomy is still an unanswered question . So far , its direct effect on immediate postoperative pulmonary lung function has never been evaluated in a prospective trial . METHODS We conducted a prospective crossover study including 10 patients undergoing pneumonectomy for lung cancer between July 2011 and July 2012 . After written informed consent , all consecutive patients who agreed to take part in the study and in whom preservation of the phrenic nerve during operation was possible , were included in the study . Upon completion of lung resection , a catheter was placed in the proximal paraphrenic tissue on the pericardial surface . After an initial phase of recovery of 5 days all patients underwent ultrasonographic assessment of diaphragmatic motion followed by lung function testing with and without induced phrenic nerve palsy . The controlled , temporary paralysis of the ipsilateral hemidiaphragm was achieved by local administration of lidocaine 1 % at a rate of 3 mL/h ( 30 mg/h ) via the above-mentioned catheter . RESULTS Temporary phrenic nerve palsy was accomplished in all but 1 patient with suspected catheter dislocation . Spirometry showed a significant decrease in dynamic lung volumes ( forced expiratory volume in 1 second and forced vital capacity ; p < 0.05 ) with the paralyzed hemidiaphragm . Blood oxygen saturation levels did not change significantly . CONCLUSIONS Our results show that phrenic nerve palsy causes a significant impairment of dynamic lung volumes during the early postoperative period after pneumonectomy . Therefore , in these already compromised patients , intraoperative phrenic nerve injury should be avoided whenever possible .	[ "Effect", "of", "phrenic", "nerve", "palsy", "on", "early", "postoperative", "lung", "function", "after", "pneumonectomy", ":", "a", "prospective", "study", ".", "BACKGROUND", "The", "issue", "of", "phrenic", "nerve", "preservation", "during", "pneumonectomy", "is", "still", "an", "unanswered", "question", ".", "So", "far", ",", "its", "direct", "effect", "on", "immediate", "postoperative", "pulmonary", "lung", "function", "has", "never", "been", "evaluated", "in", "a", "prospective", "trial", ".", "METHODS", "We", "conducted", "a", "prospective", "crossover", "study", "including", "10", "patients", "undergoing", "pneumonectomy", "for", "lung", "cancer", "between", "July", "2011", "and", "July", "2012", ".", "After", "written", "informed", "consent", ",", "all", "consecutive", "patients", "who", "agreed", "to", "take", "part", "in", "the", "study", "and", "in", "whom", "preservation", "of", "the", "phrenic", "nerve", "during", "operation", "was", "possible", ",", "were", "included", "in", "the", "study", ".", "Upon", "completion", "of", "lung", "resection", ",", "a", "catheter", "was", "placed", "in", "the", "proximal", "paraphrenic", "tissue", "on", "the", "pericardial", "surface", ".", "After", "an", "initial", "phase", "of", "recovery", "of", "5", "days", "all", "patients", "underwent", "ultrasonographic", "assessment", "of", "diaphragmatic", "motion", "followed", "by", "lung", "function", "testing", "with", "and", "without", "induced", "phrenic", "nerve", "palsy", ".", "The", "controlled", ",", "temporary", "paralysis", "of", "the", "ipsilateral", "hemidiaphragm", "was", "achieved", "by", "local", "administration", "of", "lidocaine", "1", "%", "at", "a", "rate", "of", "3", "mL", "/", "h", "(", "30", "mg", "/", "h", ")", "via", "the", "above", "-", "mentioned", "catheter", ".", "RESULTS", "Temporary", "phrenic", "nerve", "palsy", "was", "accomplished", "in", "all", "but", "1", "patient", "with", "suspected", "catheter", "dislocation", ".", "Spirometry", "showed", "a", "significant", "decrease", "in", "dynamic", "lung", "volumes", "(", "forced", "expiratory", "volume", "in", "1", "second", "and", "forced", "vital", "capacity", ";", "p", "<", "0.05", ")", "with", "the", "paralyzed", "hemidiaphragm", ".", "Blood", "oxygen", "saturation", "levels", "did", "not", "change", "significantly", ".", "CONCLUSIONS", "Our", "results", "show", "that", "phrenic", "nerve", "palsy", "causes", "a", "significant", "impairment", "of", "dynamic", "lung", "volumes", "during", "the", "early", "postoperative", "period", "after", "pneumonectomy", ".", "Therefore", ",", "in", "these", "already", "compromised", "patients", ",", "intraoperative", "phrenic", "nerve", "injury", "should", "be", "avoided", "whenever", "possible", "." ]	[ "Intervention_Other", "Intervention_Surgical", "Participant_Condition", "Participant_Sample-size" ]
phrenic nerve is a Participant_Condition, pneumonectomy is a Intervention_Surgical, 10 is a Participant_Sample-size, lung cancer is a Participant_Condition, ultrasonographic is a Intervention_Other	61358_task1	Sentence: Effect of phrenic nerve palsy on early postoperative lung function after pneumonectomy : a prospective study . BACKGROUND The issue of phrenic nerve preservation during pneumonectomy is still an unanswered question . So far , its direct effect on immediate postoperative pulmonary lung function has never been evaluated in a prospective trial . METHODS We conducted a prospective crossover study including 10 patients undergoing pneumonectomy for lung cancer between July 2011 and July 2012 . After written informed consent , all consecutive patients who agreed to take part in the study and in whom preservation of the phrenic nerve during operation was possible , were included in the study . Upon completion of lung resection , a catheter was placed in the proximal paraphrenic tissue on the pericardial surface . After an initial phase of recovery of 5 days all patients underwent ultrasonographic assessment of diaphragmatic motion followed by lung function testing with and without induced phrenic nerve palsy . The controlled , temporary paralysis of the ipsilateral hemidiaphragm was achieved by local administration of lidocaine 1 % at a rate of 3 mL/h ( 30 mg/h ) via the above-mentioned catheter . RESULTS Temporary phrenic nerve palsy was accomplished in all but 1 patient with suspected catheter dislocation . Spirometry showed a significant decrease in dynamic lung volumes ( forced expiratory volume in 1 second and forced vital capacity ; p < 0.05 ) with the paralyzed hemidiaphragm . Blood oxygen saturation levels did not change significantly . CONCLUSIONS Our results show that phrenic nerve palsy causes a significant impairment of dynamic lung volumes during the early postoperative period after pneumonectomy . Therefore , in these already compromised patients , intraoperative phrenic nerve injury should be avoided whenever possible . Instructions: please typing these entity words according to sentence: phrenic nerve, pneumonectomy, 10, lung cancer, ultrasonographic Options: Intervention_Other, Intervention_Surgical, Participant_Condition, Participant_Sample-size	[ "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Surgical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Effect of phrenic nerve palsy on early postoperative lung function after pneumonectomy : a prospective study . BACKGROUND The issue of phrenic nerve preservation during pneumonectomy is still an unanswered question . So far , its direct effect on immediate postoperative pulmonary lung function has never been evaluated in a prospective trial . METHODS We conducted a prospective crossover study including 10 patients undergoing pneumonectomy for lung cancer between July 2011 and July 2012 . After written informed consent , all consecutive patients who agreed to take part in the study and in whom preservation of the phrenic nerve during operation was possible , were included in the study . Upon completion of lung resection , a catheter was placed in the proximal paraphrenic tissue on the pericardial surface . After an initial phase of recovery of 5 days all patients underwent ultrasonographic assessment of diaphragmatic motion followed by lung function testing with and without induced phrenic nerve palsy . The controlled , temporary paralysis of the ipsilateral hemidiaphragm was achieved by local administration of lidocaine 1 % at a rate of 3 mL/h ( 30 mg/h ) via the above-mentioned catheter . RESULTS Temporary phrenic nerve palsy was accomplished in all but 1 patient with suspected catheter dislocation . Spirometry showed a significant decrease in dynamic lung volumes ( forced expiratory volume in 1 second and forced vital capacity ; p < 0.05 ) with the paralyzed hemidiaphragm . Blood oxygen saturation levels did not change significantly . CONCLUSIONS Our results show that phrenic nerve palsy causes a significant impairment of dynamic lung volumes during the early postoperative period after pneumonectomy . Therefore , in these already compromised patients , intraoperative phrenic nerve injury should be avoided whenever possible .	[ "Effect", "of", "phrenic", "nerve", "palsy", "on", "early", "postoperative", "lung", "function", "after", "pneumonectomy", ":", "a", "prospective", "study", ".", "BACKGROUND", "The", "issue", "of", "phrenic", "nerve", "preservation", "during", "pneumonectomy", "is", "still", "an", "unanswered", "question", ".", "So", "far", ",", "its", "direct", "effect", "on", "immediate", "postoperative", "pulmonary", "lung", "function", "has", "never", "been", "evaluated", "in", "a", "prospective", "trial", ".", "METHODS", "We", "conducted", "a", "prospective", "crossover", "study", "including", "10", "patients", "undergoing", "pneumonectomy", "for", "lung", "cancer", "between", "July", "2011", "and", "July", "2012", ".", "After", "written", "informed", "consent", ",", "all", "consecutive", "patients", "who", "agreed", "to", "take", "part", "in", "the", "study", "and", "in", "whom", "preservation", "of", "the", "phrenic", "nerve", "during", "operation", "was", "possible", ",", "were", "included", "in", "the", "study", ".", "Upon", "completion", "of", "lung", "resection", ",", "a", "catheter", "was", "placed", "in", "the", "proximal", "paraphrenic", "tissue", "on", "the", "pericardial", "surface", ".", "After", "an", "initial", "phase", "of", "recovery", "of", "5", "days", "all", "patients", "underwent", "ultrasonographic", "assessment", "of", "diaphragmatic", "motion", "followed", "by", "lung", "function", "testing", "with", "and", "without", "induced", "phrenic", "nerve", "palsy", ".", "The", "controlled", ",", "temporary", "paralysis", "of", "the", "ipsilateral", "hemidiaphragm", "was", "achieved", "by", "local", "administration", "of", "lidocaine", "1", "%", "at", "a", "rate", "of", "3", "mL", "/", "h", "(", "30", "mg", "/", "h", ")", "via", "the", "above", "-", "mentioned", "catheter", ".", "RESULTS", "Temporary", "phrenic", "nerve", "palsy", "was", "accomplished", "in", "all", "but", "1", "patient", "with", "suspected", "catheter", "dislocation", ".", "Spirometry", "showed", "a", "significant", "decrease", "in", "dynamic", "lung", "volumes", "(", "forced", "expiratory", "volume", "in", "1", "second", "and", "forced", "vital", "capacity", ";", "p", "<", "0.05", ")", "with", "the", "paralyzed", "hemidiaphragm", ".", "Blood", "oxygen", "saturation", "levels", "did", "not", "change", "significantly", ".", "CONCLUSIONS", "Our", "results", "show", "that", "phrenic", "nerve", "palsy", "causes", "a", "significant", "impairment", "of", "dynamic", "lung", "volumes", "during", "the", "early", "postoperative", "period", "after", "pneumonectomy", ".", "Therefore", ",", "in", "these", "already", "compromised", "patients", ",", "intraoperative", "phrenic", "nerve", "injury", "should", "be", "avoided", "whenever", "possible", "." ]	[ "Intervention_Other", "Intervention_Surgical", "Participant_Condition", "Participant_Sample-size" ]
phrenic nerve, pneumonectomy, 10, lung cancer, ultrasonographic	61358_task2	Sentence: Effect of phrenic nerve palsy on early postoperative lung function after pneumonectomy : a prospective study . BACKGROUND The issue of phrenic nerve preservation during pneumonectomy is still an unanswered question . So far , its direct effect on immediate postoperative pulmonary lung function has never been evaluated in a prospective trial . METHODS We conducted a prospective crossover study including 10 patients undergoing pneumonectomy for lung cancer between July 2011 and July 2012 . After written informed consent , all consecutive patients who agreed to take part in the study and in whom preservation of the phrenic nerve during operation was possible , were included in the study . Upon completion of lung resection , a catheter was placed in the proximal paraphrenic tissue on the pericardial surface . After an initial phase of recovery of 5 days all patients underwent ultrasonographic assessment of diaphragmatic motion followed by lung function testing with and without induced phrenic nerve palsy . The controlled , temporary paralysis of the ipsilateral hemidiaphragm was achieved by local administration of lidocaine 1 % at a rate of 3 mL/h ( 30 mg/h ) via the above-mentioned catheter . RESULTS Temporary phrenic nerve palsy was accomplished in all but 1 patient with suspected catheter dislocation . Spirometry showed a significant decrease in dynamic lung volumes ( forced expiratory volume in 1 second and forced vital capacity ; p < 0.05 ) with the paralyzed hemidiaphragm . Blood oxygen saturation levels did not change significantly . CONCLUSIONS Our results show that phrenic nerve palsy causes a significant impairment of dynamic lung volumes during the early postoperative period after pneumonectomy . Therefore , in these already compromised patients , intraoperative phrenic nerve injury should be avoided whenever possible . Instructions: please extract entity words from the input sentence	[ "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Surgical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Effect of phrenic nerve palsy on early postoperative lung function after pneumonectomy : a prospective study . BACKGROUND The issue of phrenic nerve preservation during pneumonectomy is still an unanswered question . So far , its direct effect on immediate postoperative pulmonary lung function has never been evaluated in a prospective trial . METHODS We conducted a prospective crossover study including 10 patients undergoing pneumonectomy for lung cancer between July 2011 and July 2012 . After written informed consent , all consecutive patients who agreed to take part in the study and in whom preservation of the phrenic nerve during operation was possible , were included in the study . Upon completion of lung resection , a catheter was placed in the proximal paraphrenic tissue on the pericardial surface . After an initial phase of recovery of 5 days all patients underwent ultrasonographic assessment of diaphragmatic motion followed by lung function testing with and without induced phrenic nerve palsy . The controlled , temporary paralysis of the ipsilateral hemidiaphragm was achieved by local administration of lidocaine 1 % at a rate of 3 mL/h ( 30 mg/h ) via the above-mentioned catheter . RESULTS Temporary phrenic nerve palsy was accomplished in all but 1 patient with suspected catheter dislocation . Spirometry showed a significant decrease in dynamic lung volumes ( forced expiratory volume in 1 second and forced vital capacity ; p < 0.05 ) with the paralyzed hemidiaphragm . Blood oxygen saturation levels did not change significantly . CONCLUSIONS Our results show that phrenic nerve palsy causes a significant impairment of dynamic lung volumes during the early postoperative period after pneumonectomy . Therefore , in these already compromised patients , intraoperative phrenic nerve injury should be avoided whenever possible .	[ "Effect", "of", "phrenic", "nerve", "palsy", "on", "early", "postoperative", "lung", "function", "after", "pneumonectomy", ":", "a", "prospective", "study", ".", "BACKGROUND", "The", "issue", "of", "phrenic", "nerve", "preservation", "during", "pneumonectomy", "is", "still", "an", "unanswered", "question", ".", "So", "far", ",", "its", "direct", "effect", "on", "immediate", "postoperative", "pulmonary", "lung", "function", "has", "never", "been", "evaluated", "in", "a", "prospective", "trial", ".", "METHODS", "We", "conducted", "a", "prospective", "crossover", "study", "including", "10", "patients", "undergoing", "pneumonectomy", "for", "lung", "cancer", "between", "July", "2011", "and", "July", "2012", ".", "After", "written", "informed", "consent", ",", "all", "consecutive", "patients", "who", "agreed", "to", "take", "part", "in", "the", "study", "and", "in", "whom", "preservation", "of", "the", "phrenic", "nerve", "during", "operation", "was", "possible", ",", "were", "included", "in", "the", "study", ".", "Upon", "completion", "of", "lung", "resection", ",", "a", "catheter", "was", "placed", "in", "the", "proximal", "paraphrenic", "tissue", "on", "the", "pericardial", "surface", ".", "After", "an", "initial", "phase", "of", "recovery", "of", "5", "days", "all", "patients", "underwent", "ultrasonographic", "assessment", "of", "diaphragmatic", "motion", "followed", "by", "lung", "function", "testing", "with", "and", "without", "induced", "phrenic", "nerve", "palsy", ".", "The", "controlled", ",", "temporary", "paralysis", "of", "the", "ipsilateral", "hemidiaphragm", "was", "achieved", "by", "local", "administration", "of", "lidocaine", "1", "%", "at", "a", "rate", "of", "3", "mL", "/", "h", "(", "30", "mg", "/", "h", ")", "via", "the", "above", "-", "mentioned", "catheter", ".", "RESULTS", "Temporary", "phrenic", "nerve", "palsy", "was", "accomplished", "in", "all", "but", "1", "patient", "with", "suspected", "catheter", "dislocation", ".", "Spirometry", "showed", "a", "significant", "decrease", "in", "dynamic", "lung", "volumes", "(", "forced", "expiratory", "volume", "in", "1", "second", "and", "forced", "vital", "capacity", ";", "p", "<", "0.05", ")", "with", "the", "paralyzed", "hemidiaphragm", ".", "Blood", "oxygen", "saturation", "levels", "did", "not", "change", "significantly", ".", "CONCLUSIONS", "Our", "results", "show", "that", "phrenic", "nerve", "palsy", "causes", "a", "significant", "impairment", "of", "dynamic", "lung", "volumes", "during", "the", "early", "postoperative", "period", "after", "pneumonectomy", ".", "Therefore", ",", "in", "these", "already", "compromised", "patients", ",", "intraoperative", "phrenic", "nerve", "injury", "should", "be", "avoided", "whenever", "possible", "." ]	[ "Intervention_Other", "Intervention_Surgical", "Participant_Condition", "Participant_Sample-size" ]
gelsolin is a Individual_protein, profilin is a Individual_protein, actin is a Individual_protein	546_task0	Sentence: The colocalization of gelsolin and profilin in motile, microfilament-rich areas supports the hypothesis that they synergistically regulate the actin dynamics that underlie neurite growth. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Individual_protein	[ "O", "O", "O", "B-Individual_protein", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O" ]	The colocalization of gelsolin and profilin in motile, microfilament-rich areas supports the hypothesis that they synergistically regulate the actin dynamics that underlie neurite growth.	[ "The", "colocalization", "of", "gelsolin", "and", "profilin", "in", "motile", ",", "microfilament", "-", "rich", "areas", "supports", "the", "hypothesis", "that", "they", "synergistically", "regulate", "the", "actin", "dynamics", "that", "underlie", "neurite", "growth", "." ]	[ "Individual_protein" ]
gelsolin is a Individual_protein, profilin is a Individual_protein, actin is a Individual_protein	546_task1	Sentence: The colocalization of gelsolin and profilin in motile, microfilament-rich areas supports the hypothesis that they synergistically regulate the actin dynamics that underlie neurite growth. Instructions: please typing these entity words according to sentence: gelsolin, profilin, actin Options: Individual_protein	[ "O", "O", "O", "B-Individual_protein", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O" ]	The colocalization of gelsolin and profilin in motile, microfilament-rich areas supports the hypothesis that they synergistically regulate the actin dynamics that underlie neurite growth.	[ "The", "colocalization", "of", "gelsolin", "and", "profilin", "in", "motile", ",", "microfilament", "-", "rich", "areas", "supports", "the", "hypothesis", "that", "they", "synergistically", "regulate", "the", "actin", "dynamics", "that", "underlie", "neurite", "growth", "." ]	[ "Individual_protein" ]
gelsolin, profilin, actin	546_task2	Sentence: The colocalization of gelsolin and profilin in motile, microfilament-rich areas supports the hypothesis that they synergistically regulate the actin dynamics that underlie neurite growth. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-Individual_protein", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O" ]	The colocalization of gelsolin and profilin in motile, microfilament-rich areas supports the hypothesis that they synergistically regulate the actin dynamics that underlie neurite growth.	[ "The", "colocalization", "of", "gelsolin", "and", "profilin", "in", "motile", ",", "microfilament", "-", "rich", "areas", "supports", "the", "hypothesis", "that", "they", "synergistically", "regulate", "the", "actin", "dynamics", "that", "underlie", "neurite", "growth", "." ]	[ "Individual_protein" ]
Pregnancy is a Condition, breast feeding is a Observation, Estimated life expectancy is a Observation, < 12 months is a Value, Scheduled is a Mood, major surgery is a Procedure, in the next 6 months is a Temporal, Inability to follow the protocol is a Observation, Previous is a Temporal, enrolment in this study is a Observation, treatment with an investigational drug is a Procedure, device is a Device, WHO is a Measurement, group II , III , IV , V is a Value, PH is a Condition, Severe Renal dysfunction is a Scope, Systematical inflammation is a Condition, Tricuspid valve stenosis is a Condition, Supra - pulmonary valve stenosis is a Condition, Allergic is a Condition, studied drugs or metal materials is a Scope	NCT02284737_exc_task0	Sentence: Pregnancy and breast feeding mother; Estimated life expectancy <12 months; Scheduled major surgery in the next 6 months; Inability to follow the protocol and comply with follow-up requirements or any other reason that the investigator feels would place the patient at increased risk; Previous enrolment in this study or treatment with an investigational drug or device under another study protocol in the past 30 days. WHO group II, III, IV, V PH Severe Renal dysfunction (Ccr<30 ml/min) Blood platelet count<100,000/L Expected life span<6-month Systematical inflammation Malignant cancer(s) Tricuspid valve stenosis, Supra-pulmonary valve stenosis Allergic to studied drugs or metal materials. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Temporal, Condition, Measurement, Value, Observation, Procedure, Scope, Device, Mood	[ "B-Condition", "O", "B-Observation", "I-Observation", "O", "O", "O", "B-Observation", "I-Observation", "I-Observation", "B-Value", "I-Value", "I-Value", "O", "O", "B-Mood", "B-Procedure", "I-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "B-Device", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O" ]	Pregnancy and breast feeding mother; Estimated life expectancy <12 months; Scheduled major surgery in the next 6 months; Inability to follow the protocol and comply with follow-up requirements or any other reason that the investigator feels would place the patient at increased risk; Previous enrolment in this study or treatment with an investigational drug or device under another study protocol in the past 30 days. WHO group II, III, IV, V PH Severe Renal dysfunction (Ccr<30 ml/min) Blood platelet count<100,000/L Expected life span<6-month Systematical inflammation Malignant cancer(s) Tricuspid valve stenosis, Supra-pulmonary valve stenosis Allergic to studied drugs or metal materials.	[ "Pregnancy", "and", "breast", "feeding", "mother", ";", "\n", "Estimated", "life", "expectancy", "<", "12", "months", ";", "\n", "Scheduled", "major", "surgery", "in", "the", "next", "6", "months", ";", "\n", "Inability", "to", "follow", "the", "protocol", "and", "comply", "with", "follow", "-", "up", "requirements", "or", "any", "other", "reason", "that", "the", "investigator", "feels", "would", "place", "the", "patient", "at", "increased", "risk", ";", "\n", "Previous", "enrolment", "in", "this", "study", "or", "treatment", "with", "an", "investigational", "drug", "or", "device", "under", "another", "study", "protocol", "in", "the", "past", "30", "days", ".", "\n", "WHO", "group", "II", ",", "III", ",", "IV", ",", "V", "PH", "\n", "Severe", "Renal", "dysfunction", "(", "Ccr<30", "ml", "/", "min", ")", "\n", "Blood", "platelet", "count<100,000", "/", "L", "\n", "Expected", "life", "span<6-month", "\n", "Systematical", "inflammation", "\n", "Malignant", "cancer(s", ")", "\n", "Tricuspid", "valve", "stenosis", ",", "Supra", "-", "pulmonary", "valve", "stenosis", "\n", "Allergic", "to", "studied", "drugs", "or", "metal", "materials", ".", "\n" ]	[ "Procedure", "Scope", "Observation", "Condition", "Temporal", "Value", "Measurement", "Drug", "Mood", "Qualifier", "Device" ]
Pregnancy is a Condition, breast feeding is a Observation, Estimated life expectancy is a Observation, < 12 months is a Value, Scheduled is a Mood, major surgery is a Procedure, in the next 6 months is a Temporal, Inability to follow the protocol is a Observation, Previous is a Temporal, enrolment in this study is a Observation, treatment with an investigational drug is a Procedure, device is a Device, WHO is a Measurement, group II , III , IV , V is a Value, PH is a Condition, Severe Renal dysfunction is a Scope, Systematical inflammation is a Condition, Tricuspid valve stenosis is a Condition, Supra - pulmonary valve stenosis is a Condition, Allergic is a Condition, studied drugs or metal materials is a Scope	NCT02284737_exc_task1	Sentence: Pregnancy and breast feeding mother; Estimated life expectancy <12 months; Scheduled major surgery in the next 6 months; Inability to follow the protocol and comply with follow-up requirements or any other reason that the investigator feels would place the patient at increased risk; Previous enrolment in this study or treatment with an investigational drug or device under another study protocol in the past 30 days. WHO group II, III, IV, V PH Severe Renal dysfunction (Ccr<30 ml/min) Blood platelet count<100,000/L Expected life span<6-month Systematical inflammation Malignant cancer(s) Tricuspid valve stenosis, Supra-pulmonary valve stenosis Allergic to studied drugs or metal materials. Instructions: please typing these entity words according to sentence: Pregnancy, breast feeding, Estimated life expectancy, < 12 months, Scheduled, major surgery, in the next 6 months, Inability to follow the protocol, Previous, enrolment in this study, treatment with an investigational drug, device, WHO, group II , III , IV , V, PH, Severe Renal dysfunction, Systematical inflammation, Tricuspid valve stenosis, Supra - pulmonary valve stenosis, Allergic, studied drugs or metal materials Options: Temporal, Condition, Measurement, Value, Observation, Procedure, Scope, Device, Mood	[ "B-Condition", "O", "B-Observation", "I-Observation", "O", "O", "O", "B-Observation", "I-Observation", "I-Observation", "B-Value", "I-Value", "I-Value", "O", "O", "B-Mood", "B-Procedure", "I-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "B-Device", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O" ]	Pregnancy and breast feeding mother; Estimated life expectancy <12 months; Scheduled major surgery in the next 6 months; Inability to follow the protocol and comply with follow-up requirements or any other reason that the investigator feels would place the patient at increased risk; Previous enrolment in this study or treatment with an investigational drug or device under another study protocol in the past 30 days. WHO group II, III, IV, V PH Severe Renal dysfunction (Ccr<30 ml/min) Blood platelet count<100,000/L Expected life span<6-month Systematical inflammation Malignant cancer(s) Tricuspid valve stenosis, Supra-pulmonary valve stenosis Allergic to studied drugs or metal materials.	[ "Pregnancy", "and", "breast", "feeding", "mother", ";", "\n", "Estimated", "life", "expectancy", "<", "12", "months", ";", "\n", "Scheduled", "major", "surgery", "in", "the", "next", "6", "months", ";", "\n", "Inability", "to", "follow", "the", "protocol", "and", "comply", "with", "follow", "-", "up", "requirements", "or", "any", "other", "reason", "that", "the", "investigator", "feels", "would", "place", "the", "patient", "at", "increased", "risk", ";", "\n", "Previous", "enrolment", "in", "this", "study", "or", "treatment", "with", "an", "investigational", "drug", "or", "device", "under", "another", "study", "protocol", "in", "the", "past", "30", "days", ".", "\n", "WHO", "group", "II", ",", "III", ",", "IV", ",", "V", "PH", "\n", "Severe", "Renal", "dysfunction", "(", "Ccr<30", "ml", "/", "min", ")", "\n", "Blood", "platelet", "count<100,000", "/", "L", "\n", "Expected", "life", "span<6-month", "\n", "Systematical", "inflammation", "\n", "Malignant", "cancer(s", ")", "\n", "Tricuspid", "valve", "stenosis", ",", "Supra", "-", "pulmonary", "valve", "stenosis", "\n", "Allergic", "to", "studied", "drugs", "or", "metal", "materials", ".", "\n" ]	[ "Procedure", "Scope", "Observation", "Condition", "Temporal", "Value", "Measurement", "Drug", "Mood", "Qualifier", "Device" ]
Pregnancy, breast feeding, Estimated life expectancy, < 12 months, Scheduled, major surgery, in the next 6 months, Inability to follow the protocol, Previous, enrolment in this study, treatment with an investigational drug, device, WHO, group II , III , IV , V, PH, Severe Renal dysfunction, Systematical inflammation, Tricuspid valve stenosis, Supra - pulmonary valve stenosis, Allergic, studied drugs or metal materials	NCT02284737_exc_task2	Sentence: Pregnancy and breast feeding mother; Estimated life expectancy <12 months; Scheduled major surgery in the next 6 months; Inability to follow the protocol and comply with follow-up requirements or any other reason that the investigator feels would place the patient at increased risk; Previous enrolment in this study or treatment with an investigational drug or device under another study protocol in the past 30 days. WHO group II, III, IV, V PH Severe Renal dysfunction (Ccr<30 ml/min) Blood platelet count<100,000/L Expected life span<6-month Systematical inflammation Malignant cancer(s) Tricuspid valve stenosis, Supra-pulmonary valve stenosis Allergic to studied drugs or metal materials. Instructions: please extract entity words from the input sentence	[ "B-Condition", "O", "B-Observation", "I-Observation", "O", "O", "O", "B-Observation", "I-Observation", "I-Observation", "B-Value", "I-Value", "I-Value", "O", "O", "B-Mood", "B-Procedure", "I-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "B-Device", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O" ]	Pregnancy and breast feeding mother; Estimated life expectancy <12 months; Scheduled major surgery in the next 6 months; Inability to follow the protocol and comply with follow-up requirements or any other reason that the investigator feels would place the patient at increased risk; Previous enrolment in this study or treatment with an investigational drug or device under another study protocol in the past 30 days. WHO group II, III, IV, V PH Severe Renal dysfunction (Ccr<30 ml/min) Blood platelet count<100,000/L Expected life span<6-month Systematical inflammation Malignant cancer(s) Tricuspid valve stenosis, Supra-pulmonary valve stenosis Allergic to studied drugs or metal materials.	[ "Pregnancy", "and", "breast", "feeding", "mother", ";", "\n", "Estimated", "life", "expectancy", "<", "12", "months", ";", "\n", "Scheduled", "major", "surgery", "in", "the", "next", "6", "months", ";", "\n", "Inability", "to", "follow", "the", "protocol", "and", "comply", "with", "follow", "-", "up", "requirements", "or", "any", "other", "reason", "that", "the", "investigator", "feels", "would", "place", "the", "patient", "at", "increased", "risk", ";", "\n", "Previous", "enrolment", "in", "this", "study", "or", "treatment", "with", "an", "investigational", "drug", "or", "device", "under", "another", "study", "protocol", "in", "the", "past", "30", "days", ".", "\n", "WHO", "group", "II", ",", "III", ",", "IV", ",", "V", "PH", "\n", "Severe", "Renal", "dysfunction", "(", "Ccr<30", "ml", "/", "min", ")", "\n", "Blood", "platelet", "count<100,000", "/", "L", "\n", "Expected", "life", "span<6-month", "\n", "Systematical", "inflammation", "\n", "Malignant", "cancer(s", ")", "\n", "Tricuspid", "valve", "stenosis", ",", "Supra", "-", "pulmonary", "valve", "stenosis", "\n", "Allergic", "to", "studied", "drugs", "or", "metal", "materials", ".", "\n" ]	[ "Procedure", "Scope", "Observation", "Condition", "Temporal", "Value", "Measurement", "Drug", "Mood", "Qualifier", "Device" ]
Medikamente is an umlsterm, Blutfluss is an umlsterm, Blutflussveraenderungen is an umlsterm, Uvea is an umlsterm, Literatur is an umlsterm, Blutfluss is an umlsterm, Augenpols is an umlsterm, Zeit is an umlsterm, Placebo - kontrollierte is an umlsterm, Blutfluss is an umlsterm	DerOpthalmologe.90960706.ger.abstr_task0	Sentence: Hintergrund : Viele der antiglaukomatoesen Medikamente beeinflussen den okulaeren Blutfluss . Die Blutflussveraenderungen in der vorderen Uvea sind in der Literatur beschrieben . Ueber den Effekt von Antiglaukomatosa auf den Blutfluss des hinteren Augenpols wird in neuerer Zeit vermehrt berichtet . Wir praesentieren eine Placebo-kontrollierte Studie mit Blick auf den kurz- und mittelfristigen Einfluss von topisch appliziertem Dipivefrin 0,1 % auf den retinalen und papillaeren Blutfluss . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Hintergrund : Viele der antiglaukomatoesen Medikamente beeinflussen den okulaeren Blutfluss . Die Blutflussveraenderungen in der vorderen Uvea sind in der Literatur beschrieben . Ueber den Effekt von Antiglaukomatosa auf den Blutfluss des hinteren Augenpols wird in neuerer Zeit vermehrt berichtet . Wir praesentieren eine Placebo-kontrollierte Studie mit Blick auf den kurz- und mittelfristigen Einfluss von topisch appliziertem Dipivefrin 0,1 % auf den retinalen und papillaeren Blutfluss .	[ "Hintergrund", ":", "Viele", "der", "antiglaukomatoesen", "Medikamente", "beeinflussen", "den", "okulaeren", "Blutfluss", ".", "Die", "Blutflussveraenderungen", "in", "der", "vorderen", "Uvea", "sind", "in", "der", "Literatur", "beschrieben", ".", "Ueber", "den", "Effekt", "von", "Antiglaukomatosa", "auf", "den", "Blutfluss", "des", "hinteren", "Augenpols", "wird", "in", "neuerer", "Zeit", "vermehrt", "berichtet", ".", "Wir", "praesentieren", "eine", "Placebo", "-", "kontrollierte", "Studie", "mit", "Blick", "auf", "den", "kurz-", "und", "mittelfristigen", "Einfluss", "von", "topisch", "appliziertem", "Dipivefrin", "0,1", "%", "auf", "den", "retinalen", "und", "papillaeren", "Blutfluss", "." ]	[ "umlsterm" ]
Medikamente is an umlsterm, Blutfluss is an umlsterm, Blutflussveraenderungen is an umlsterm, Uvea is an umlsterm, Literatur is an umlsterm, Blutfluss is an umlsterm, Augenpols is an umlsterm, Zeit is an umlsterm, Placebo - kontrollierte is an umlsterm, Blutfluss is an umlsterm	DerOpthalmologe.90960706.ger.abstr_task1	Sentence: Hintergrund : Viele der antiglaukomatoesen Medikamente beeinflussen den okulaeren Blutfluss . Die Blutflussveraenderungen in der vorderen Uvea sind in der Literatur beschrieben . Ueber den Effekt von Antiglaukomatosa auf den Blutfluss des hinteren Augenpols wird in neuerer Zeit vermehrt berichtet . Wir praesentieren eine Placebo-kontrollierte Studie mit Blick auf den kurz- und mittelfristigen Einfluss von topisch appliziertem Dipivefrin 0,1 % auf den retinalen und papillaeren Blutfluss . Instructions: please typing these entity words according to sentence: Medikamente, Blutfluss, Blutflussveraenderungen, Uvea, Literatur, Blutfluss, Augenpols, Zeit, Placebo - kontrollierte, Blutfluss Options: umlsterm	[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Hintergrund : Viele der antiglaukomatoesen Medikamente beeinflussen den okulaeren Blutfluss . Die Blutflussveraenderungen in der vorderen Uvea sind in der Literatur beschrieben . Ueber den Effekt von Antiglaukomatosa auf den Blutfluss des hinteren Augenpols wird in neuerer Zeit vermehrt berichtet . Wir praesentieren eine Placebo-kontrollierte Studie mit Blick auf den kurz- und mittelfristigen Einfluss von topisch appliziertem Dipivefrin 0,1 % auf den retinalen und papillaeren Blutfluss .	[ "Hintergrund", ":", "Viele", "der", "antiglaukomatoesen", "Medikamente", "beeinflussen", "den", "okulaeren", "Blutfluss", ".", "Die", "Blutflussveraenderungen", "in", "der", "vorderen", "Uvea", "sind", "in", "der", "Literatur", "beschrieben", ".", "Ueber", "den", "Effekt", "von", "Antiglaukomatosa", "auf", "den", "Blutfluss", "des", "hinteren", "Augenpols", "wird", "in", "neuerer", "Zeit", "vermehrt", "berichtet", ".", "Wir", "praesentieren", "eine", "Placebo", "-", "kontrollierte", "Studie", "mit", "Blick", "auf", "den", "kurz-", "und", "mittelfristigen", "Einfluss", "von", "topisch", "appliziertem", "Dipivefrin", "0,1", "%", "auf", "den", "retinalen", "und", "papillaeren", "Blutfluss", "." ]	[ "umlsterm" ]
Medikamente, Blutfluss, Blutflussveraenderungen, Uvea, Literatur, Blutfluss, Augenpols, Zeit, Placebo - kontrollierte, Blutfluss	DerOpthalmologe.90960706.ger.abstr_task2	Sentence: Hintergrund : Viele der antiglaukomatoesen Medikamente beeinflussen den okulaeren Blutfluss . Die Blutflussveraenderungen in der vorderen Uvea sind in der Literatur beschrieben . Ueber den Effekt von Antiglaukomatosa auf den Blutfluss des hinteren Augenpols wird in neuerer Zeit vermehrt berichtet . Wir praesentieren eine Placebo-kontrollierte Studie mit Blick auf den kurz- und mittelfristigen Einfluss von topisch appliziertem Dipivefrin 0,1 % auf den retinalen und papillaeren Blutfluss . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Hintergrund : Viele der antiglaukomatoesen Medikamente beeinflussen den okulaeren Blutfluss . Die Blutflussveraenderungen in der vorderen Uvea sind in der Literatur beschrieben . Ueber den Effekt von Antiglaukomatosa auf den Blutfluss des hinteren Augenpols wird in neuerer Zeit vermehrt berichtet . Wir praesentieren eine Placebo-kontrollierte Studie mit Blick auf den kurz- und mittelfristigen Einfluss von topisch appliziertem Dipivefrin 0,1 % auf den retinalen und papillaeren Blutfluss .	[ "Hintergrund", ":", "Viele", "der", "antiglaukomatoesen", "Medikamente", "beeinflussen", "den", "okulaeren", "Blutfluss", ".", "Die", "Blutflussveraenderungen", "in", "der", "vorderen", "Uvea", "sind", "in", "der", "Literatur", "beschrieben", ".", "Ueber", "den", "Effekt", "von", "Antiglaukomatosa", "auf", "den", "Blutfluss", "des", "hinteren", "Augenpols", "wird", "in", "neuerer", "Zeit", "vermehrt", "berichtet", ".", "Wir", "praesentieren", "eine", "Placebo", "-", "kontrollierte", "Studie", "mit", "Blick", "auf", "den", "kurz-", "und", "mittelfristigen", "Einfluss", "von", "topisch", "appliziertem", "Dipivefrin", "0,1", "%", "auf", "den", "retinalen", "und", "papillaeren", "Blutfluss", "." ]	[ "umlsterm" ]
syndrome is an umlsterm, fibromas is an umlsterm, colonic polyps is an umlsterm, literature is an umlsterm, fibromas is an umlsterm, mother is an umlsterm, daughter is an umlsterm, mother is an umlsterm, colonic polyps is an umlsterm, syndrome is an umlsterm, syndrome is an umlsterm, syndrome is an umlsterm, fibromas is an umlsterm, sequelae is an umlsterm, acne is an umlsterm, patient is an umlsterm, colonic polyps is an umlsterm, cancer is an umlsterm, screening is an umlsterm	DerHautarzt.60470304.eng.abstr_task0	Sentence: The syndrome of perifollicular fibromas and colonic polyps was delineated 20 years ago by Hornstein and Knickenberg ; it probably occurs more frequently than suggested by the literature . Multiple perifollicular fibromas were found in a mother and daughter . The mother also had colonic polyps . This dermo-intestinal syndrome varies in its clinical manifestations , but it is probably an autosomal dominant trait . We believe that the Hornstein-Knickenberg syndrome and the Birt-Hogg-Dubé syndrome are identical . If perifollicular fibromas are observed and cannot be explained as postinflammatory sequelae of acne , the patient should be examined for colonic polyps as an appropriate form of cancer screening . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O" ]	The syndrome of perifollicular fibromas and colonic polyps was delineated 20 years ago by Hornstein and Knickenberg ; it probably occurs more frequently than suggested by the literature . Multiple perifollicular fibromas were found in a mother and daughter . The mother also had colonic polyps . This dermo-intestinal syndrome varies in its clinical manifestations , but it is probably an autosomal dominant trait . We believe that the Hornstein-Knickenberg syndrome and the Birt-Hogg-Dubé syndrome are identical . If perifollicular fibromas are observed and cannot be explained as postinflammatory sequelae of acne , the patient should be examined for colonic polyps as an appropriate form of cancer screening .	[ "The", "syndrome", "of", "perifollicular", "fibromas", "and", "colonic", "polyps", "was", "delineated", "20", "years", "ago", "by", "Hornstein", "and", "Knickenberg", ";", "it", "probably", "occurs", "more", "frequently", "than", "suggested", "by", "the", "literature", ".", "Multiple", "perifollicular", "fibromas", "were", "found", "in", "a", "mother", "and", "daughter", ".", "The", "mother", "also", "had", "colonic", "polyps", ".", "This", "dermo", "-", "intestinal", "syndrome", "varies", "in", "its", "clinical", "manifestations", ",", "but", "it", "is", "probably", "an", "autosomal", "dominant", "trait", ".", "We", "believe", "that", "the", "Hornstein", "-", "Knickenberg", "syndrome", "and", "the", "Birt", "-", "Hogg", "-", "Dubé", "syndrome", "are", "identical", ".", "If", "perifollicular", "fibromas", "are", "observed", "and", "cannot", "be", "explained", "as", "postinflammatory", "sequelae", "of", "acne", ",", "the", "patient", "should", "be", "examined", "for", "colonic", "polyps", "as", "an", "appropriate", "form", "of", "cancer", "screening", "." ]	[ "umlsterm" ]
syndrome is an umlsterm, fibromas is an umlsterm, colonic polyps is an umlsterm, literature is an umlsterm, fibromas is an umlsterm, mother is an umlsterm, daughter is an umlsterm, mother is an umlsterm, colonic polyps is an umlsterm, syndrome is an umlsterm, syndrome is an umlsterm, syndrome is an umlsterm, fibromas is an umlsterm, sequelae is an umlsterm, acne is an umlsterm, patient is an umlsterm, colonic polyps is an umlsterm, cancer is an umlsterm, screening is an umlsterm	DerHautarzt.60470304.eng.abstr_task1	Sentence: The syndrome of perifollicular fibromas and colonic polyps was delineated 20 years ago by Hornstein and Knickenberg ; it probably occurs more frequently than suggested by the literature . Multiple perifollicular fibromas were found in a mother and daughter . The mother also had colonic polyps . This dermo-intestinal syndrome varies in its clinical manifestations , but it is probably an autosomal dominant trait . We believe that the Hornstein-Knickenberg syndrome and the Birt-Hogg-Dubé syndrome are identical . If perifollicular fibromas are observed and cannot be explained as postinflammatory sequelae of acne , the patient should be examined for colonic polyps as an appropriate form of cancer screening . Instructions: please typing these entity words according to sentence: syndrome, fibromas, colonic polyps, literature, fibromas, mother, daughter, mother, colonic polyps, syndrome, syndrome, syndrome, fibromas, sequelae, acne, patient, colonic polyps, cancer, screening Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O" ]	The syndrome of perifollicular fibromas and colonic polyps was delineated 20 years ago by Hornstein and Knickenberg ; it probably occurs more frequently than suggested by the literature . Multiple perifollicular fibromas were found in a mother and daughter . The mother also had colonic polyps . This dermo-intestinal syndrome varies in its clinical manifestations , but it is probably an autosomal dominant trait . We believe that the Hornstein-Knickenberg syndrome and the Birt-Hogg-Dubé syndrome are identical . If perifollicular fibromas are observed and cannot be explained as postinflammatory sequelae of acne , the patient should be examined for colonic polyps as an appropriate form of cancer screening .	[ "The", "syndrome", "of", "perifollicular", "fibromas", "and", "colonic", "polyps", "was", "delineated", "20", "years", "ago", "by", "Hornstein", "and", "Knickenberg", ";", "it", "probably", "occurs", "more", "frequently", "than", "suggested", "by", "the", "literature", ".", "Multiple", "perifollicular", "fibromas", "were", "found", "in", "a", "mother", "and", "daughter", ".", "The", "mother", "also", "had", "colonic", "polyps", ".", "This", "dermo", "-", "intestinal", "syndrome", "varies", "in", "its", "clinical", "manifestations", ",", "but", "it", "is", "probably", "an", "autosomal", "dominant", "trait", ".", "We", "believe", "that", "the", "Hornstein", "-", "Knickenberg", "syndrome", "and", "the", "Birt", "-", "Hogg", "-", "Dubé", "syndrome", "are", "identical", ".", "If", "perifollicular", "fibromas", "are", "observed", "and", "cannot", "be", "explained", "as", "postinflammatory", "sequelae", "of", "acne", ",", "the", "patient", "should", "be", "examined", "for", "colonic", "polyps", "as", "an", "appropriate", "form", "of", "cancer", "screening", "." ]	[ "umlsterm" ]
syndrome, fibromas, colonic polyps, literature, fibromas, mother, daughter, mother, colonic polyps, syndrome, syndrome, syndrome, fibromas, sequelae, acne, patient, colonic polyps, cancer, screening	DerHautarzt.60470304.eng.abstr_task2	Sentence: The syndrome of perifollicular fibromas and colonic polyps was delineated 20 years ago by Hornstein and Knickenberg ; it probably occurs more frequently than suggested by the literature . Multiple perifollicular fibromas were found in a mother and daughter . The mother also had colonic polyps . This dermo-intestinal syndrome varies in its clinical manifestations , but it is probably an autosomal dominant trait . We believe that the Hornstein-Knickenberg syndrome and the Birt-Hogg-Dubé syndrome are identical . If perifollicular fibromas are observed and cannot be explained as postinflammatory sequelae of acne , the patient should be examined for colonic polyps as an appropriate form of cancer screening . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O" ]	The syndrome of perifollicular fibromas and colonic polyps was delineated 20 years ago by Hornstein and Knickenberg ; it probably occurs more frequently than suggested by the literature . Multiple perifollicular fibromas were found in a mother and daughter . The mother also had colonic polyps . This dermo-intestinal syndrome varies in its clinical manifestations , but it is probably an autosomal dominant trait . We believe that the Hornstein-Knickenberg syndrome and the Birt-Hogg-Dubé syndrome are identical . If perifollicular fibromas are observed and cannot be explained as postinflammatory sequelae of acne , the patient should be examined for colonic polyps as an appropriate form of cancer screening .	[ "The", "syndrome", "of", "perifollicular", "fibromas", "and", "colonic", "polyps", "was", "delineated", "20", "years", "ago", "by", "Hornstein", "and", "Knickenberg", ";", "it", "probably", "occurs", "more", "frequently", "than", "suggested", "by", "the", "literature", ".", "Multiple", "perifollicular", "fibromas", "were", "found", "in", "a", "mother", "and", "daughter", ".", "The", "mother", "also", "had", "colonic", "polyps", ".", "This", "dermo", "-", "intestinal", "syndrome", "varies", "in", "its", "clinical", "manifestations", ",", "but", "it", "is", "probably", "an", "autosomal", "dominant", "trait", ".", "We", "believe", "that", "the", "Hornstein", "-", "Knickenberg", "syndrome", "and", "the", "Birt", "-", "Hogg", "-", "Dubé", "syndrome", "are", "identical", ".", "If", "perifollicular", "fibromas", "are", "observed", "and", "cannot", "be", "explained", "as", "postinflammatory", "sequelae", "of", "acne", ",", "the", "patient", "should", "be", "examined", "for", "colonic", "polyps", "as", "an", "appropriate", "form", "of", "cancer", "screening", "." ]	[ "umlsterm" ]
Mateo is a NOMBRE_SUJETO_ASISTENCIA, Sanchez Rivas is a NOMBRE_SUJETO_ASISTENCIA, 7806239 is a ID_SUJETO_ASISTENCIA, Almeria is a TERRITORIO, 04201 is a TERRITORIO, 21/08/2001 is a FECHAS, España is a PAIS, 16 años is a EDAD_SUJETO_ASISTENCIA, 01/04/2018 is a FECHAS, Ana Cristina Cis Spoturno is a NOMBRE_PERSONAL_SANITARIO, 04 04 52302 is a ID_TITULACION_PERSONAL_SANITARIO, adolescente is a ID_SUJETO_ASISTENCIA, 16 años is a EDAD_SUJETO_ASISTENCIA, jugador de baloncesto de competición is a ID_SUJETO_ASISTENCIA, 5 años is a EDAD_SUJETO_ASISTENCIA, Centro Andaluz de Medicina del Deporte ( CAMD ) is a INSTITUCION, Almería is a TERRITORIO, 9 años is a EDAD_SUJETO_ASISTENCIA, tío paterno is a FAMILIARES_SUJETO_ASISTENCIA, padres is a FAMILIARES_SUJETO_ASISTENCIA, Ana Cristina Cis Spoturno is a NOMBRE_PERSONAL_SANITARIO, Centro Médico Deportivo is a INSTITUCION, Federico Garcia Lorca 50 is a CALLE, 04006 is a TERRITORIO, Almeria is a TERRITORIO, España is a PAIS, cmedicodeportivo@gmail.com is a CORREO_ELECTRONICO	497_task0	Sentence: Datos del paciente. Nombre: Mateo. Apellidos: Sanchez Rivas. NHC: 7806239. Domicilio: Calle Sancho Martin, 34, 2 A. Localidad/ Provincia: Almeria. CP: 04201. Datos asistenciales. Fecha de nacimiento: 21/08/2001. País: España. Edad: 16 años Sexo: H. Fecha de Ingreso: 01/04/2018. Médico: Ana Cristina Cis Spoturno NºCol: 04 04 52302. Informe clínico del paciente: adolescente de 16 años, jugador de baloncesto de competición desde los 5 años, que acudió al Centro Andaluz de Medicina del Deporte (CAMD) de Almería, para realizar un examen médico solicitado por su Federación. En la anamnesis refiere episodios de palpitaciones, cortos y autolimitados, durante el reposo y el esfuerzo. En el ECG de reposo se detectó un intervalo entre ondas P y R (intervalo PR) muy corto con onda delta, compatible con preexcitación por lo que fue derivado para valoración cardiológica. Destacan entre sus antecedentes personales una evaluación previa a los 9 años, en un paciente asintomático, con un ECG normal y la referencia de un tío paterno, afectado con una arritmia recientemente ablacionado. Un nuevo ECG de reposo confirmó un ritmo sinusal preexcitado, compatible con vía anteroseptal derecha y se descartó cardiopatía estructural mediante ecocardiografía. En el holter de ritmo de 24 horas, mantuvo preexcitación permanente y sin arritmias. La prueba de esfuerzo en cinta, con protocolo de Bruce fue concluyente y libre de arritmias, manteniendo el WPW a frecuencias cardíacas máximas. Considerando los datos previos y su condición de deportista de competición, fue enviado para estudio electrofisiológico (EEF) y ablación de vía anómala. El procedimiento fue realizado con dos electrocatéteres: uno para diagnóstico con registro del His y otro para mapeo y ablación en región septal perihisiana. En ritmo sinusal se indujo taquicardia ortodrómica y se aplicó radiofrecuencia (RF) sobre la vía accesoria auriculo-ventricular (AV) de conducción bidireccional. Se interrumpe la taquicardia y la preexcitación, finalizando el procedimiento. Quedó con bloqueo de rama derecha (BRD), de probable origen traumático. No hay descripción de período refractario efectivo de la vía anómala. En el primer control posterior, el paciente refiere la misma clínica anterior a la ablación y su manejo para interrumpir las taquicardias. El ECG basal y el holter de 24 horas, mantienen el patrón sinusal con WPW, sin documentarse taquicardias. Se ha planteado a los padres realizar nueva consulta al especialista en electrofisiología para ofrecerle las mejores opciones de tratamiento en relación a la práctica deportiva. Remitido por: Dra. Ana Cristina Cis Spoturno Centro Médico Deportivo Federico Garcia Lorca 50 04006 Almeria. España Correo electrónico: cmedicodeportivo@gmail.com Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: TERRITORIO, ID_SUJETO_ASISTENCIA, FECHAS, FAMILIARES_SUJETO_ASISTENCIA, CALLE, CORREO_ELECTRONICO, PAIS, EDAD_SUJETO_ASISTENCIA, INSTITUCION, ID_TITULACION_PERSONAL_SANITARIO, NOMBRE_SUJETO_ASISTENCIA, NOMBRE_PERSONAL_SANITARIO	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-NOMBRE_SUJETO_ASISTENCIA", "O", "O", "O", "O", "B-NOMBRE_SUJETO_ASISTENCIA", "I-NOMBRE_SUJETO_ASISTENCIA", "O", "O", "O", "O", "B-ID_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-TERRITORIO", "O", "O", "O", "O", "B-TERRITORIO", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-FECHAS", "O", "O", "O", "O", "B-PAIS", "O", "O", "O", "O", "B-EDAD_SUJETO_ASISTENCIA", "I-EDAD_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "B-FECHAS", "O", "O", "O", "O", "O", "B-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "O", "O", "B-ID_TITULACION_PERSONAL_SANITARIO", "I-ID_TITULACION_PERSONAL_SANITARIO", "I-ID_TITULACION_PERSONAL_SANITARIO", "O", "O", "O", "O", "O", "O", "O", "B-ID_SUJETO_ASISTENCIA", "O", "B-EDAD_SUJETO_ASISTENCIA", "I-EDAD_SUJETO_ASISTENCIA", "O", "B-ID_SUJETO_ASISTENCIA", "I-ID_SUJETO_ASISTENCIA", "I-ID_SUJETO_ASISTENCIA", "I-ID_SUJETO_ASISTENCIA", "I-ID_SUJETO_ASISTENCIA", "O", "O", "B-EDAD_SUJETO_ASISTENCIA", "I-EDAD_SUJETO_ASISTENCIA", "O", "O", "O", "O", "B-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "O", "B-TERRITORIO", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-EDAD_SUJETO_ASISTENCIA", "I-EDAD_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-FAMILIARES_SUJETO_ASISTENCIA", "I-FAMILIARES_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-FAMILIARES_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "B-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "B-CALLE", "I-CALLE", "I-CALLE", "I-CALLE", "B-TERRITORIO", "B-TERRITORIO", "O", "B-PAIS", "O", "O", "O", "B-CORREO_ELECTRONICO", "O" ]	Datos del paciente. Nombre: Mateo. Apellidos: Sanchez Rivas. NHC: 7806239. Domicilio: Calle Sancho Martin, 34, 2 A. Localidad/ Provincia: Almeria. CP: 04201. Datos asistenciales. Fecha de nacimiento: 21/08/2001. País: España. Edad: 16 años Sexo: H. Fecha de Ingreso: 01/04/2018. Médico: Ana Cristina Cis Spoturno NºCol: 04 04 52302. Informe clínico del paciente: adolescente de 16 años, jugador de baloncesto de competición desde los 5 años, que acudió al Centro Andaluz de Medicina del Deporte (CAMD) de Almería, para realizar un examen médico solicitado por su Federación. En la anamnesis refiere episodios de palpitaciones, cortos y autolimitados, durante el reposo y el esfuerzo. En el ECG de reposo se detectó un intervalo entre ondas P y R (intervalo PR) muy corto con onda delta, compatible con preexcitación por lo que fue derivado para valoración cardiológica. Destacan entre sus antecedentes personales una evaluación previa a los 9 años, en un paciente asintomático, con un ECG normal y la referencia de un tío paterno, afectado con una arritmia recientemente ablacionado. Un nuevo ECG de reposo confirmó un ritmo sinusal preexcitado, compatible con vía anteroseptal derecha y se descartó cardiopatía estructural mediante ecocardiografía. En el holter de ritmo de 24 horas, mantuvo preexcitación permanente y sin arritmias. La prueba de esfuerzo en cinta, con protocolo de Bruce fue concluyente y libre de arritmias, manteniendo el WPW a frecuencias cardíacas máximas. Considerando los datos previos y su condición de deportista de competición, fue enviado para estudio electrofisiológico (EEF) y ablación de vía anómala. El procedimiento fue realizado con dos electrocatéteres: uno para diagnóstico con registro del His y otro para mapeo y ablación en región septal perihisiana. En ritmo sinusal se indujo taquicardia ortodrómica y se aplicó radiofrecuencia (RF) sobre la vía accesoria auriculo-ventricular (AV) de conducción bidireccional. Se interrumpe la taquicardia y la preexcitación, finalizando el procedimiento. Quedó con bloqueo de rama derecha (BRD), de probable origen traumático. No hay descripción de período refractario efectivo de la vía anómala. En el primer control posterior, el paciente refiere la misma clínica anterior a la ablación y su manejo para interrumpir las taquicardias. El ECG basal y el holter de 24 horas, mantienen el patrón sinusal con WPW, sin documentarse taquicardias. Se ha planteado a los padres realizar nueva consulta al especialista en electrofisiología para ofrecerle las mejores opciones de tratamiento en relación a la práctica deportiva. Remitido por: Dra. Ana Cristina Cis Spoturno Centro Médico Deportivo Federico Garcia Lorca 50 04006 Almeria. España Correo electrónico: cmedicodeportivo@gmail.com	[ "Datos", "del", "paciente", ".", "\n", "Nombre", ":", " ", "Mateo", ".", "\n", "Apellidos", ":", "Sanchez", "Rivas", ".", "\n", "NHC", ":", "7806239", ".", "\n", "Domicilio", ":", "Calle", "Sancho", "Martin", ",", "34", ",", "2", "A.", "\n", "Localidad/", "Provincia", ":", "Almeria", ".", "\n", "CP", ":", "04201", ".", "\n", "Datos", "asistenciales", ".", "\n", "Fecha", "de", "nacimiento", ":", "21/08/2001", ".", "\n", "País", ":", "España", ".", "\n", "Edad", ":", "16", "años", "Sexo", ":", "H.", "\n", "Fecha", "de", "Ingreso", ":", "01/04/2018", ".", "\n", "Médico", ":", " ", "Ana", "Cristina", "Cis", "Spoturno", "NºCol", ":", "04", "04", "52302", ".", "\n", "Informe", "clínico", "del", "paciente", ":", "adolescente", "de", "16", "años", ",", "jugador", "de", "baloncesto", "de", "competición", "desde", "los", "5", "años", ",", "que", "acudió", "al", "Centro", "Andaluz", "de", "Medicina", "del", "Deporte", "(", "CAMD", ")", "de", "Almería", ",", "para", "realizar", "un", "examen", "médico", "solicitado", "por", "su", "Federación", ".", "En", "la", "anamnesis", "refiere", "episodios", "de", "palpitaciones", ",", "cortos", "y", "autolimitados", ",", "durante", "el", "reposo", "y", "el", "esfuerzo", ".", "En", "el", "ECG", "de", "reposo", "se", "detectó", "un", "intervalo", "entre", "ondas", "P", "y", "R", "(", "intervalo", "PR", ")", "muy", "corto", "con", "onda", "delta", ",", "compatible", "con", "preexcitación", "por", "lo", "que", "fue", "derivado", "para", "valoración", "cardiológica", ".", "\n", "Destacan", "entre", "sus", "antecedentes", "personales", "una", "evaluación", "previa", "a", "los", "9", "años", ",", "en", "un", "paciente", "asintomático", ",", "con", "un", "ECG", "normal", "y", "la", "referencia", "de", "un", "tío", "paterno", ",", "afectado", "con", "una", "arritmia", "recientemente", "ablacionado", ".", "\n", "Un", "nuevo", "ECG", "de", "reposo", "confirmó", "un", "ritmo", "sinusal", "preexcitado", ",", "compatible", "con", "vía", "anteroseptal", "derecha", "y", "se", "descartó", "cardiopatía", "estructural", "mediante", "ecocardiografía", ".", "En", "el", "holter", "de", "ritmo", "de", "24", "horas", ",", "mantuvo", "preexcitación", "permanente", "y", "sin", "arritmias", ".", "La", "prueba", "de", "esfuerzo", "en", "cinta", ",", "con", "protocolo", "de", "Bruce", "fue", "concluyente", "y", "libre", "de", "arritmias", ",", "manteniendo", "el", "WPW", "a", "frecuencias", "cardíacas", "máximas", ".", "\n", "Considerando", "los", "datos", "previos", "y", "su", "condición", "de", "deportista", "de", "competición", ",", "fue", "enviado", "para", "estudio", "electrofisiológico", "(", "EEF", ")", "y", "ablación", "de", "vía", "anómala", ".", "\n", "El", "procedimiento", "fue", "realizado", "con", "dos", "electrocatéteres", ":", "uno", "para", "diagnóstico", "con", "registro", "del", "His", "y", "otro", "para", "mapeo", "y", "ablación", "en", "región", "septal", "perihisiana", ".", "En", "ritmo", "sinusal", "se", "indujo", "taquicardia", "ortodrómica", "y", "se", "aplicó", "radiofrecuencia", "(", "RF", ")", "sobre", "la", "vía", "accesoria", "auriculo", "-", "ventricular", "(", "AV", ")", "de", "conducción", "bidireccional", ".", "Se", "interrumpe", "la", "taquicardia", "y", "la", "preexcitación", ",", "finalizando", "el", "procedimiento", ".", "Quedó", "con", "bloqueo", "de", "rama", "derecha", "(", "BRD", ")", ",", "de", "probable", "origen", "traumático", ".", "No", "hay", "descripción", "de", "período", "refractario", "efectivo", "de", "la", "vía", "anómala", ".", "\n", "En", "el", "primer", "control", "posterior", ",", "el", "paciente", "refiere", "la", "misma", "clínica", "anterior", "a", "la", "ablación", "y", "su", "manejo", "para", "interrumpir", "las", "taquicardias", ".", "El", "ECG", "basal", "y", "el", "holter", "de", "24", "horas", ",", "mantienen", "el", "patrón", "sinusal", "con", "WPW", ",", "sin", "documentarse", "taquicardias", ".", "\n", "Se", "ha", "planteado", "a", "los", "padres", "realizar", "nueva", "consulta", "al", "especialista", "en", "electrofisiología", "para", "ofrecerle", "las", "mejores", "opciones", "de", "tratamiento", "en", "relación", "a", "la", "práctica", "deportiva", ".", "\n", "Remitido", "por", ":", "Dra", ".", "Ana", "Cristina", "Cis", "Spoturno", "Centro", "Médico", "Deportivo", "Federico", "Garcia", "Lorca", "50", "04006", "Almeria", ".", "España", "Correo", "electrónico", ":", "cmedicodeportivo@gmail.com", "\n" ]	[ "INSTITUCION", "ID_SUJETO_ASISTENCIA", "CALLE", "CORREO_ELECTRONICO", "NOMBRE_PERSONAL_SANITARIO", "NOMBRE_SUJETO_ASISTENCIA", "FAMILIARES_SUJETO_ASISTENCIA", "ID_TITULACION_PERSONAL_SANITARIO", "FECHAS", "TERRITORIO", "EDAD_SUJETO_ASISTENCIA", "PAIS", "SEXO_SUJETO_ASISTENCIA" ]
Mateo is a NOMBRE_SUJETO_ASISTENCIA, Sanchez Rivas is a NOMBRE_SUJETO_ASISTENCIA, 7806239 is a ID_SUJETO_ASISTENCIA, Almeria is a TERRITORIO, 04201 is a TERRITORIO, 21/08/2001 is a FECHAS, España is a PAIS, 16 años is a EDAD_SUJETO_ASISTENCIA, 01/04/2018 is a FECHAS, Ana Cristina Cis Spoturno is a NOMBRE_PERSONAL_SANITARIO, 04 04 52302 is a ID_TITULACION_PERSONAL_SANITARIO, adolescente is a ID_SUJETO_ASISTENCIA, 16 años is a EDAD_SUJETO_ASISTENCIA, jugador de baloncesto de competición is a ID_SUJETO_ASISTENCIA, 5 años is a EDAD_SUJETO_ASISTENCIA, Centro Andaluz de Medicina del Deporte ( CAMD ) is a INSTITUCION, Almería is a TERRITORIO, 9 años is a EDAD_SUJETO_ASISTENCIA, tío paterno is a FAMILIARES_SUJETO_ASISTENCIA, padres is a FAMILIARES_SUJETO_ASISTENCIA, Ana Cristina Cis Spoturno is a NOMBRE_PERSONAL_SANITARIO, Centro Médico Deportivo is a INSTITUCION, Federico Garcia Lorca 50 is a CALLE, 04006 is a TERRITORIO, Almeria is a TERRITORIO, España is a PAIS, cmedicodeportivo@gmail.com is a CORREO_ELECTRONICO	497_task1	Sentence: Datos del paciente. Nombre: Mateo. Apellidos: Sanchez Rivas. NHC: 7806239. Domicilio: Calle Sancho Martin, 34, 2 A. Localidad/ Provincia: Almeria. CP: 04201. Datos asistenciales. Fecha de nacimiento: 21/08/2001. País: España. Edad: 16 años Sexo: H. Fecha de Ingreso: 01/04/2018. Médico: Ana Cristina Cis Spoturno NºCol: 04 04 52302. Informe clínico del paciente: adolescente de 16 años, jugador de baloncesto de competición desde los 5 años, que acudió al Centro Andaluz de Medicina del Deporte (CAMD) de Almería, para realizar un examen médico solicitado por su Federación. En la anamnesis refiere episodios de palpitaciones, cortos y autolimitados, durante el reposo y el esfuerzo. En el ECG de reposo se detectó un intervalo entre ondas P y R (intervalo PR) muy corto con onda delta, compatible con preexcitación por lo que fue derivado para valoración cardiológica. Destacan entre sus antecedentes personales una evaluación previa a los 9 años, en un paciente asintomático, con un ECG normal y la referencia de un tío paterno, afectado con una arritmia recientemente ablacionado. Un nuevo ECG de reposo confirmó un ritmo sinusal preexcitado, compatible con vía anteroseptal derecha y se descartó cardiopatía estructural mediante ecocardiografía. En el holter de ritmo de 24 horas, mantuvo preexcitación permanente y sin arritmias. La prueba de esfuerzo en cinta, con protocolo de Bruce fue concluyente y libre de arritmias, manteniendo el WPW a frecuencias cardíacas máximas. Considerando los datos previos y su condición de deportista de competición, fue enviado para estudio electrofisiológico (EEF) y ablación de vía anómala. El procedimiento fue realizado con dos electrocatéteres: uno para diagnóstico con registro del His y otro para mapeo y ablación en región septal perihisiana. En ritmo sinusal se indujo taquicardia ortodrómica y se aplicó radiofrecuencia (RF) sobre la vía accesoria auriculo-ventricular (AV) de conducción bidireccional. Se interrumpe la taquicardia y la preexcitación, finalizando el procedimiento. Quedó con bloqueo de rama derecha (BRD), de probable origen traumático. No hay descripción de período refractario efectivo de la vía anómala. En el primer control posterior, el paciente refiere la misma clínica anterior a la ablación y su manejo para interrumpir las taquicardias. El ECG basal y el holter de 24 horas, mantienen el patrón sinusal con WPW, sin documentarse taquicardias. Se ha planteado a los padres realizar nueva consulta al especialista en electrofisiología para ofrecerle las mejores opciones de tratamiento en relación a la práctica deportiva. Remitido por: Dra. Ana Cristina Cis Spoturno Centro Médico Deportivo Federico Garcia Lorca 50 04006 Almeria. España Correo electrónico: cmedicodeportivo@gmail.com Instructions: please typing these entity words according to sentence: Mateo, Sanchez Rivas, 7806239, Almeria, 04201, 21/08/2001, España, 16 años, 01/04/2018, Ana Cristina Cis Spoturno, 04 04 52302, adolescente, 16 años, jugador de baloncesto de competición, 5 años, Centro Andaluz de Medicina del Deporte ( CAMD ), Almería, 9 años, tío paterno, padres, Ana Cristina Cis Spoturno, Centro Médico Deportivo, Federico Garcia Lorca 50, 04006, Almeria, España, cmedicodeportivo@gmail.com Options: TERRITORIO, ID_SUJETO_ASISTENCIA, FECHAS, FAMILIARES_SUJETO_ASISTENCIA, CALLE, CORREO_ELECTRONICO, PAIS, EDAD_SUJETO_ASISTENCIA, INSTITUCION, ID_TITULACION_PERSONAL_SANITARIO, NOMBRE_SUJETO_ASISTENCIA, NOMBRE_PERSONAL_SANITARIO	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-NOMBRE_SUJETO_ASISTENCIA", "O", "O", "O", "O", "B-NOMBRE_SUJETO_ASISTENCIA", "I-NOMBRE_SUJETO_ASISTENCIA", "O", "O", "O", "O", "B-ID_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-TERRITORIO", "O", "O", "O", "O", "B-TERRITORIO", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-FECHAS", "O", "O", "O", "O", "B-PAIS", "O", "O", "O", "O", "B-EDAD_SUJETO_ASISTENCIA", "I-EDAD_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "B-FECHAS", "O", "O", "O", "O", "O", "B-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "O", "O", "B-ID_TITULACION_PERSONAL_SANITARIO", "I-ID_TITULACION_PERSONAL_SANITARIO", "I-ID_TITULACION_PERSONAL_SANITARIO", "O", "O", "O", "O", "O", "O", "O", "B-ID_SUJETO_ASISTENCIA", "O", "B-EDAD_SUJETO_ASISTENCIA", "I-EDAD_SUJETO_ASISTENCIA", "O", "B-ID_SUJETO_ASISTENCIA", "I-ID_SUJETO_ASISTENCIA", "I-ID_SUJETO_ASISTENCIA", "I-ID_SUJETO_ASISTENCIA", "I-ID_SUJETO_ASISTENCIA", "O", "O", "B-EDAD_SUJETO_ASISTENCIA", "I-EDAD_SUJETO_ASISTENCIA", "O", "O", "O", "O", "B-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "O", "B-TERRITORIO", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-EDAD_SUJETO_ASISTENCIA", "I-EDAD_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-FAMILIARES_SUJETO_ASISTENCIA", "I-FAMILIARES_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-FAMILIARES_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "B-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "B-CALLE", "I-CALLE", "I-CALLE", "I-CALLE", "B-TERRITORIO", "B-TERRITORIO", "O", "B-PAIS", "O", "O", "O", "B-CORREO_ELECTRONICO", "O" ]	Datos del paciente. Nombre: Mateo. Apellidos: Sanchez Rivas. NHC: 7806239. Domicilio: Calle Sancho Martin, 34, 2 A. Localidad/ Provincia: Almeria. CP: 04201. Datos asistenciales. Fecha de nacimiento: 21/08/2001. País: España. Edad: 16 años Sexo: H. Fecha de Ingreso: 01/04/2018. Médico: Ana Cristina Cis Spoturno NºCol: 04 04 52302. Informe clínico del paciente: adolescente de 16 años, jugador de baloncesto de competición desde los 5 años, que acudió al Centro Andaluz de Medicina del Deporte (CAMD) de Almería, para realizar un examen médico solicitado por su Federación. En la anamnesis refiere episodios de palpitaciones, cortos y autolimitados, durante el reposo y el esfuerzo. En el ECG de reposo se detectó un intervalo entre ondas P y R (intervalo PR) muy corto con onda delta, compatible con preexcitación por lo que fue derivado para valoración cardiológica. Destacan entre sus antecedentes personales una evaluación previa a los 9 años, en un paciente asintomático, con un ECG normal y la referencia de un tío paterno, afectado con una arritmia recientemente ablacionado. Un nuevo ECG de reposo confirmó un ritmo sinusal preexcitado, compatible con vía anteroseptal derecha y se descartó cardiopatía estructural mediante ecocardiografía. En el holter de ritmo de 24 horas, mantuvo preexcitación permanente y sin arritmias. La prueba de esfuerzo en cinta, con protocolo de Bruce fue concluyente y libre de arritmias, manteniendo el WPW a frecuencias cardíacas máximas. Considerando los datos previos y su condición de deportista de competición, fue enviado para estudio electrofisiológico (EEF) y ablación de vía anómala. El procedimiento fue realizado con dos electrocatéteres: uno para diagnóstico con registro del His y otro para mapeo y ablación en región septal perihisiana. En ritmo sinusal se indujo taquicardia ortodrómica y se aplicó radiofrecuencia (RF) sobre la vía accesoria auriculo-ventricular (AV) de conducción bidireccional. Se interrumpe la taquicardia y la preexcitación, finalizando el procedimiento. Quedó con bloqueo de rama derecha (BRD), de probable origen traumático. No hay descripción de período refractario efectivo de la vía anómala. En el primer control posterior, el paciente refiere la misma clínica anterior a la ablación y su manejo para interrumpir las taquicardias. El ECG basal y el holter de 24 horas, mantienen el patrón sinusal con WPW, sin documentarse taquicardias. Se ha planteado a los padres realizar nueva consulta al especialista en electrofisiología para ofrecerle las mejores opciones de tratamiento en relación a la práctica deportiva. Remitido por: Dra. Ana Cristina Cis Spoturno Centro Médico Deportivo Federico Garcia Lorca 50 04006 Almeria. España Correo electrónico: cmedicodeportivo@gmail.com	[ "Datos", "del", "paciente", ".", "\n", "Nombre", ":", " ", "Mateo", ".", "\n", "Apellidos", ":", "Sanchez", "Rivas", ".", "\n", "NHC", ":", "7806239", ".", "\n", "Domicilio", ":", "Calle", "Sancho", "Martin", ",", "34", ",", "2", "A.", "\n", "Localidad/", "Provincia", ":", "Almeria", ".", "\n", "CP", ":", "04201", ".", "\n", "Datos", "asistenciales", ".", "\n", "Fecha", "de", "nacimiento", ":", "21/08/2001", ".", "\n", "País", ":", "España", ".", "\n", "Edad", ":", "16", "años", "Sexo", ":", "H.", "\n", "Fecha", "de", "Ingreso", ":", "01/04/2018", ".", "\n", "Médico", ":", " ", "Ana", "Cristina", "Cis", "Spoturno", "NºCol", ":", "04", "04", "52302", ".", "\n", "Informe", "clínico", "del", "paciente", ":", "adolescente", "de", "16", "años", ",", "jugador", "de", "baloncesto", "de", "competición", "desde", "los", "5", "años", ",", "que", "acudió", "al", "Centro", "Andaluz", "de", "Medicina", "del", "Deporte", "(", "CAMD", ")", "de", "Almería", ",", "para", "realizar", "un", "examen", "médico", "solicitado", "por", "su", "Federación", ".", "En", "la", "anamnesis", "refiere", "episodios", "de", "palpitaciones", ",", "cortos", "y", "autolimitados", ",", "durante", "el", "reposo", "y", "el", "esfuerzo", ".", "En", "el", "ECG", "de", "reposo", "se", "detectó", "un", "intervalo", "entre", "ondas", "P", "y", "R", "(", "intervalo", "PR", ")", "muy", "corto", "con", "onda", "delta", ",", "compatible", "con", "preexcitación", "por", "lo", "que", "fue", "derivado", "para", "valoración", "cardiológica", ".", "\n", "Destacan", "entre", "sus", "antecedentes", "personales", "una", "evaluación", "previa", "a", "los", "9", "años", ",", "en", "un", "paciente", "asintomático", ",", "con", "un", "ECG", "normal", "y", "la", "referencia", "de", "un", "tío", "paterno", ",", "afectado", "con", "una", "arritmia", "recientemente", "ablacionado", ".", "\n", "Un", "nuevo", "ECG", "de", "reposo", "confirmó", "un", "ritmo", "sinusal", "preexcitado", ",", "compatible", "con", "vía", "anteroseptal", "derecha", "y", "se", "descartó", "cardiopatía", "estructural", "mediante", "ecocardiografía", ".", "En", "el", "holter", "de", "ritmo", "de", "24", "horas", ",", "mantuvo", "preexcitación", "permanente", "y", "sin", "arritmias", ".", "La", "prueba", "de", "esfuerzo", "en", "cinta", ",", "con", "protocolo", "de", "Bruce", "fue", "concluyente", "y", "libre", "de", "arritmias", ",", "manteniendo", "el", "WPW", "a", "frecuencias", "cardíacas", "máximas", ".", "\n", "Considerando", "los", "datos", "previos", "y", "su", "condición", "de", "deportista", "de", "competición", ",", "fue", "enviado", "para", "estudio", "electrofisiológico", "(", "EEF", ")", "y", "ablación", "de", "vía", "anómala", ".", "\n", "El", "procedimiento", "fue", "realizado", "con", "dos", "electrocatéteres", ":", "uno", "para", "diagnóstico", "con", "registro", "del", "His", "y", "otro", "para", "mapeo", "y", "ablación", "en", "región", "septal", "perihisiana", ".", "En", "ritmo", "sinusal", "se", "indujo", "taquicardia", "ortodrómica", "y", "se", "aplicó", "radiofrecuencia", "(", "RF", ")", "sobre", "la", "vía", "accesoria", "auriculo", "-", "ventricular", "(", "AV", ")", "de", "conducción", "bidireccional", ".", "Se", "interrumpe", "la", "taquicardia", "y", "la", "preexcitación", ",", "finalizando", "el", "procedimiento", ".", "Quedó", "con", "bloqueo", "de", "rama", "derecha", "(", "BRD", ")", ",", "de", "probable", "origen", "traumático", ".", "No", "hay", "descripción", "de", "período", "refractario", "efectivo", "de", "la", "vía", "anómala", ".", "\n", "En", "el", "primer", "control", "posterior", ",", "el", "paciente", "refiere", "la", "misma", "clínica", "anterior", "a", "la", "ablación", "y", "su", "manejo", "para", "interrumpir", "las", "taquicardias", ".", "El", "ECG", "basal", "y", "el", "holter", "de", "24", "horas", ",", "mantienen", "el", "patrón", "sinusal", "con", "WPW", ",", "sin", "documentarse", "taquicardias", ".", "\n", "Se", "ha", "planteado", "a", "los", "padres", "realizar", "nueva", "consulta", "al", "especialista", "en", "electrofisiología", "para", "ofrecerle", "las", "mejores", "opciones", "de", "tratamiento", "en", "relación", "a", "la", "práctica", "deportiva", ".", "\n", "Remitido", "por", ":", "Dra", ".", "Ana", "Cristina", "Cis", "Spoturno", "Centro", "Médico", "Deportivo", "Federico", "Garcia", "Lorca", "50", "04006", "Almeria", ".", "España", "Correo", "electrónico", ":", "cmedicodeportivo@gmail.com", "\n" ]	[ "INSTITUCION", "ID_SUJETO_ASISTENCIA", "CALLE", "CORREO_ELECTRONICO", "NOMBRE_PERSONAL_SANITARIO", "NOMBRE_SUJETO_ASISTENCIA", "FAMILIARES_SUJETO_ASISTENCIA", "ID_TITULACION_PERSONAL_SANITARIO", "FECHAS", "TERRITORIO", "EDAD_SUJETO_ASISTENCIA", "PAIS", "SEXO_SUJETO_ASISTENCIA" ]
Mateo, Sanchez Rivas, 7806239, Almeria, 04201, 21/08/2001, España, 16 años, 01/04/2018, Ana Cristina Cis Spoturno, 04 04 52302, adolescente, 16 años, jugador de baloncesto de competición, 5 años, Centro Andaluz de Medicina del Deporte ( CAMD ), Almería, 9 años, tío paterno, padres, Ana Cristina Cis Spoturno, Centro Médico Deportivo, Federico Garcia Lorca 50, 04006, Almeria, España, cmedicodeportivo@gmail.com	497_task2	Sentence: Datos del paciente. Nombre: Mateo. Apellidos: Sanchez Rivas. NHC: 7806239. Domicilio: Calle Sancho Martin, 34, 2 A. Localidad/ Provincia: Almeria. CP: 04201. Datos asistenciales. Fecha de nacimiento: 21/08/2001. País: España. Edad: 16 años Sexo: H. Fecha de Ingreso: 01/04/2018. Médico: Ana Cristina Cis Spoturno NºCol: 04 04 52302. Informe clínico del paciente: adolescente de 16 años, jugador de baloncesto de competición desde los 5 años, que acudió al Centro Andaluz de Medicina del Deporte (CAMD) de Almería, para realizar un examen médico solicitado por su Federación. En la anamnesis refiere episodios de palpitaciones, cortos y autolimitados, durante el reposo y el esfuerzo. En el ECG de reposo se detectó un intervalo entre ondas P y R (intervalo PR) muy corto con onda delta, compatible con preexcitación por lo que fue derivado para valoración cardiológica. Destacan entre sus antecedentes personales una evaluación previa a los 9 años, en un paciente asintomático, con un ECG normal y la referencia de un tío paterno, afectado con una arritmia recientemente ablacionado. Un nuevo ECG de reposo confirmó un ritmo sinusal preexcitado, compatible con vía anteroseptal derecha y se descartó cardiopatía estructural mediante ecocardiografía. En el holter de ritmo de 24 horas, mantuvo preexcitación permanente y sin arritmias. La prueba de esfuerzo en cinta, con protocolo de Bruce fue concluyente y libre de arritmias, manteniendo el WPW a frecuencias cardíacas máximas. Considerando los datos previos y su condición de deportista de competición, fue enviado para estudio electrofisiológico (EEF) y ablación de vía anómala. El procedimiento fue realizado con dos electrocatéteres: uno para diagnóstico con registro del His y otro para mapeo y ablación en región septal perihisiana. En ritmo sinusal se indujo taquicardia ortodrómica y se aplicó radiofrecuencia (RF) sobre la vía accesoria auriculo-ventricular (AV) de conducción bidireccional. Se interrumpe la taquicardia y la preexcitación, finalizando el procedimiento. Quedó con bloqueo de rama derecha (BRD), de probable origen traumático. No hay descripción de período refractario efectivo de la vía anómala. En el primer control posterior, el paciente refiere la misma clínica anterior a la ablación y su manejo para interrumpir las taquicardias. El ECG basal y el holter de 24 horas, mantienen el patrón sinusal con WPW, sin documentarse taquicardias. Se ha planteado a los padres realizar nueva consulta al especialista en electrofisiología para ofrecerle las mejores opciones de tratamiento en relación a la práctica deportiva. Remitido por: Dra. Ana Cristina Cis Spoturno Centro Médico Deportivo Federico Garcia Lorca 50 04006 Almeria. España Correo electrónico: cmedicodeportivo@gmail.com Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-NOMBRE_SUJETO_ASISTENCIA", "O", "O", "O", "O", "B-NOMBRE_SUJETO_ASISTENCIA", "I-NOMBRE_SUJETO_ASISTENCIA", "O", "O", "O", "O", "B-ID_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-TERRITORIO", "O", "O", "O", "O", "B-TERRITORIO", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-FECHAS", "O", "O", "O", "O", "B-PAIS", "O", "O", "O", "O", "B-EDAD_SUJETO_ASISTENCIA", "I-EDAD_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "B-FECHAS", "O", "O", "O", "O", "O", "B-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "O", "O", "B-ID_TITULACION_PERSONAL_SANITARIO", "I-ID_TITULACION_PERSONAL_SANITARIO", "I-ID_TITULACION_PERSONAL_SANITARIO", "O", "O", "O", "O", "O", "O", "O", "B-ID_SUJETO_ASISTENCIA", "O", "B-EDAD_SUJETO_ASISTENCIA", "I-EDAD_SUJETO_ASISTENCIA", "O", "B-ID_SUJETO_ASISTENCIA", "I-ID_SUJETO_ASISTENCIA", "I-ID_SUJETO_ASISTENCIA", "I-ID_SUJETO_ASISTENCIA", "I-ID_SUJETO_ASISTENCIA", "O", "O", "B-EDAD_SUJETO_ASISTENCIA", "I-EDAD_SUJETO_ASISTENCIA", "O", "O", "O", "O", "B-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "O", "B-TERRITORIO", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-EDAD_SUJETO_ASISTENCIA", "I-EDAD_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-FAMILIARES_SUJETO_ASISTENCIA", "I-FAMILIARES_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-FAMILIARES_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "B-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "B-CALLE", "I-CALLE", "I-CALLE", "I-CALLE", "B-TERRITORIO", "B-TERRITORIO", "O", "B-PAIS", "O", "O", "O", "B-CORREO_ELECTRONICO", "O" ]	Datos del paciente. Nombre: Mateo. Apellidos: Sanchez Rivas. NHC: 7806239. Domicilio: Calle Sancho Martin, 34, 2 A. Localidad/ Provincia: Almeria. CP: 04201. Datos asistenciales. Fecha de nacimiento: 21/08/2001. País: España. Edad: 16 años Sexo: H. Fecha de Ingreso: 01/04/2018. Médico: Ana Cristina Cis Spoturno NºCol: 04 04 52302. Informe clínico del paciente: adolescente de 16 años, jugador de baloncesto de competición desde los 5 años, que acudió al Centro Andaluz de Medicina del Deporte (CAMD) de Almería, para realizar un examen médico solicitado por su Federación. En la anamnesis refiere episodios de palpitaciones, cortos y autolimitados, durante el reposo y el esfuerzo. En el ECG de reposo se detectó un intervalo entre ondas P y R (intervalo PR) muy corto con onda delta, compatible con preexcitación por lo que fue derivado para valoración cardiológica. Destacan entre sus antecedentes personales una evaluación previa a los 9 años, en un paciente asintomático, con un ECG normal y la referencia de un tío paterno, afectado con una arritmia recientemente ablacionado. Un nuevo ECG de reposo confirmó un ritmo sinusal preexcitado, compatible con vía anteroseptal derecha y se descartó cardiopatía estructural mediante ecocardiografía. En el holter de ritmo de 24 horas, mantuvo preexcitación permanente y sin arritmias. La prueba de esfuerzo en cinta, con protocolo de Bruce fue concluyente y libre de arritmias, manteniendo el WPW a frecuencias cardíacas máximas. Considerando los datos previos y su condición de deportista de competición, fue enviado para estudio electrofisiológico (EEF) y ablación de vía anómala. El procedimiento fue realizado con dos electrocatéteres: uno para diagnóstico con registro del His y otro para mapeo y ablación en región septal perihisiana. En ritmo sinusal se indujo taquicardia ortodrómica y se aplicó radiofrecuencia (RF) sobre la vía accesoria auriculo-ventricular (AV) de conducción bidireccional. Se interrumpe la taquicardia y la preexcitación, finalizando el procedimiento. Quedó con bloqueo de rama derecha (BRD), de probable origen traumático. No hay descripción de período refractario efectivo de la vía anómala. En el primer control posterior, el paciente refiere la misma clínica anterior a la ablación y su manejo para interrumpir las taquicardias. El ECG basal y el holter de 24 horas, mantienen el patrón sinusal con WPW, sin documentarse taquicardias. Se ha planteado a los padres realizar nueva consulta al especialista en electrofisiología para ofrecerle las mejores opciones de tratamiento en relación a la práctica deportiva. Remitido por: Dra. Ana Cristina Cis Spoturno Centro Médico Deportivo Federico Garcia Lorca 50 04006 Almeria. España Correo electrónico: cmedicodeportivo@gmail.com	[ "Datos", "del", "paciente", ".", "\n", "Nombre", ":", " ", "Mateo", ".", "\n", "Apellidos", ":", "Sanchez", "Rivas", ".", "\n", "NHC", ":", "7806239", ".", "\n", "Domicilio", ":", "Calle", "Sancho", "Martin", ",", "34", ",", "2", "A.", "\n", "Localidad/", "Provincia", ":", "Almeria", ".", "\n", "CP", ":", "04201", ".", "\n", "Datos", "asistenciales", ".", "\n", "Fecha", "de", "nacimiento", ":", "21/08/2001", ".", "\n", "País", ":", "España", ".", "\n", "Edad", ":", "16", "años", "Sexo", ":", "H.", "\n", "Fecha", "de", "Ingreso", ":", "01/04/2018", ".", "\n", "Médico", ":", " ", "Ana", "Cristina", "Cis", "Spoturno", "NºCol", ":", "04", "04", "52302", ".", "\n", "Informe", "clínico", "del", "paciente", ":", "adolescente", "de", "16", "años", ",", "jugador", "de", "baloncesto", "de", "competición", "desde", "los", "5", "años", ",", "que", "acudió", "al", "Centro", "Andaluz", "de", "Medicina", "del", "Deporte", "(", "CAMD", ")", "de", "Almería", ",", "para", "realizar", "un", "examen", "médico", "solicitado", "por", "su", "Federación", ".", "En", "la", "anamnesis", "refiere", "episodios", "de", "palpitaciones", ",", "cortos", "y", "autolimitados", ",", "durante", "el", "reposo", "y", "el", "esfuerzo", ".", "En", "el", "ECG", "de", "reposo", "se", "detectó", "un", "intervalo", "entre", "ondas", "P", "y", "R", "(", "intervalo", "PR", ")", "muy", "corto", "con", "onda", "delta", ",", "compatible", "con", "preexcitación", "por", "lo", "que", "fue", "derivado", "para", "valoración", "cardiológica", ".", "\n", "Destacan", "entre", "sus", "antecedentes", "personales", "una", "evaluación", "previa", "a", "los", "9", "años", ",", "en", "un", "paciente", "asintomático", ",", "con", "un", "ECG", "normal", "y", "la", "referencia", "de", "un", "tío", "paterno", ",", "afectado", "con", "una", "arritmia", "recientemente", "ablacionado", ".", "\n", "Un", "nuevo", "ECG", "de", "reposo", "confirmó", "un", "ritmo", "sinusal", "preexcitado", ",", "compatible", "con", "vía", "anteroseptal", "derecha", "y", "se", "descartó", "cardiopatía", "estructural", "mediante", "ecocardiografía", ".", "En", "el", "holter", "de", "ritmo", "de", "24", "horas", ",", "mantuvo", "preexcitación", "permanente", "y", "sin", "arritmias", ".", "La", "prueba", "de", "esfuerzo", "en", "cinta", ",", "con", "protocolo", "de", "Bruce", "fue", "concluyente", "y", "libre", "de", "arritmias", ",", "manteniendo", "el", "WPW", "a", "frecuencias", "cardíacas", "máximas", ".", "\n", "Considerando", "los", "datos", "previos", "y", "su", "condición", "de", "deportista", "de", "competición", ",", "fue", "enviado", "para", "estudio", "electrofisiológico", "(", "EEF", ")", "y", "ablación", "de", "vía", "anómala", ".", "\n", "El", "procedimiento", "fue", "realizado", "con", "dos", "electrocatéteres", ":", "uno", "para", "diagnóstico", "con", "registro", "del", "His", "y", "otro", "para", "mapeo", "y", "ablación", "en", "región", "septal", "perihisiana", ".", "En", "ritmo", "sinusal", "se", "indujo", "taquicardia", "ortodrómica", "y", "se", "aplicó", "radiofrecuencia", "(", "RF", ")", "sobre", "la", "vía", "accesoria", "auriculo", "-", "ventricular", "(", "AV", ")", "de", "conducción", "bidireccional", ".", "Se", "interrumpe", "la", "taquicardia", "y", "la", "preexcitación", ",", "finalizando", "el", "procedimiento", ".", "Quedó", "con", "bloqueo", "de", "rama", "derecha", "(", "BRD", ")", ",", "de", "probable", "origen", "traumático", ".", "No", "hay", "descripción", "de", "período", "refractario", "efectivo", "de", "la", "vía", "anómala", ".", "\n", "En", "el", "primer", "control", "posterior", ",", "el", "paciente", "refiere", "la", "misma", "clínica", "anterior", "a", "la", "ablación", "y", "su", "manejo", "para", "interrumpir", "las", "taquicardias", ".", "El", "ECG", "basal", "y", "el", "holter", "de", "24", "horas", ",", "mantienen", "el", "patrón", "sinusal", "con", "WPW", ",", "sin", "documentarse", "taquicardias", ".", "\n", "Se", "ha", "planteado", "a", "los", "padres", "realizar", "nueva", "consulta", "al", "especialista", "en", "electrofisiología", "para", "ofrecerle", "las", "mejores", "opciones", "de", "tratamiento", "en", "relación", "a", "la", "práctica", "deportiva", ".", "\n", "Remitido", "por", ":", "Dra", ".", "Ana", "Cristina", "Cis", "Spoturno", "Centro", "Médico", "Deportivo", "Federico", "Garcia", "Lorca", "50", "04006", "Almeria", ".", "España", "Correo", "electrónico", ":", "cmedicodeportivo@gmail.com", "\n" ]	[ "INSTITUCION", "ID_SUJETO_ASISTENCIA", "CALLE", "CORREO_ELECTRONICO", "NOMBRE_PERSONAL_SANITARIO", "NOMBRE_SUJETO_ASISTENCIA", "FAMILIARES_SUJETO_ASISTENCIA", "ID_TITULACION_PERSONAL_SANITARIO", "FECHAS", "TERRITORIO", "EDAD_SUJETO_ASISTENCIA", "PAIS", "SEXO_SUJETO_ASISTENCIA" ]
balloon angioplasty is an umlsterm, PTA is an umlsterm, treatment is an umlsterm, disease is an umlsterm	DerRadiologe.90390144.eng.abstr_task0	Sentence: Purpose : To evaluate whether primary stenting is superior to balloon angioplasty ( PTA ) alone in the treatment of femoropopliteal obstructive disease . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O" ]	Purpose : To evaluate whether primary stenting is superior to balloon angioplasty ( PTA ) alone in the treatment of femoropopliteal obstructive disease .	[ "Purpose", ":", "To", "evaluate", "whether", "primary", "stenting", "is", "superior", "to", "balloon", "angioplasty", "(", "PTA", ")", "alone", "in", "the", "treatment", "of", "femoropopliteal", "obstructive", "disease", "." ]	[ "umlsterm" ]
balloon angioplasty is an umlsterm, PTA is an umlsterm, treatment is an umlsterm, disease is an umlsterm	DerRadiologe.90390144.eng.abstr_task1	Sentence: Purpose : To evaluate whether primary stenting is superior to balloon angioplasty ( PTA ) alone in the treatment of femoropopliteal obstructive disease . Instructions: please typing these entity words according to sentence: balloon angioplasty, PTA, treatment, disease Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O" ]	Purpose : To evaluate whether primary stenting is superior to balloon angioplasty ( PTA ) alone in the treatment of femoropopliteal obstructive disease .	[ "Purpose", ":", "To", "evaluate", "whether", "primary", "stenting", "is", "superior", "to", "balloon", "angioplasty", "(", "PTA", ")", "alone", "in", "the", "treatment", "of", "femoropopliteal", "obstructive", "disease", "." ]	[ "umlsterm" ]
balloon angioplasty, PTA, treatment, disease	DerRadiologe.90390144.eng.abstr_task2	Sentence: Purpose : To evaluate whether primary stenting is superior to balloon angioplasty ( PTA ) alone in the treatment of femoropopliteal obstructive disease . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O" ]	Purpose : To evaluate whether primary stenting is superior to balloon angioplasty ( PTA ) alone in the treatment of femoropopliteal obstructive disease .	[ "Purpose", ":", "To", "evaluate", "whether", "primary", "stenting", "is", "superior", "to", "balloon", "angioplasty", "(", "PTA", ")", "alone", "in", "the", "treatment", "of", "femoropopliteal", "obstructive", "disease", "." ]	[ "umlsterm" ]
gunshot wounds is an umlsterm, head is an umlsterm, neck is an umlsterm, injuries is an umlsterm, head is an umlsterm, neck is an umlsterm, therapeutic is an umlsterm, injuries is an umlsterm, treatment is an umlsterm, choice is an umlsterm, conventional surgery is an umlsterm, stress is an umlsterm, patient is an umlsterm	MundKieferGesichtschirurgie.90030102.eng.abstr_task0	Sentence: Internal gunshot wounds in the head and neck region are complicated . Two cases of such injuries in the head and neck region are introduced and therapeutic approaches are discussed . If there are no severe additional injuries , the treatment of choice is the endoscopic removal of the projectile . Alternatively , the projectile has to be taken out by conventional surgery , using the approach which induces the least stress for the patient . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]	Internal gunshot wounds in the head and neck region are complicated . Two cases of such injuries in the head and neck region are introduced and therapeutic approaches are discussed . If there are no severe additional injuries , the treatment of choice is the endoscopic removal of the projectile . Alternatively , the projectile has to be taken out by conventional surgery , using the approach which induces the least stress for the patient .	[ "Internal", "gunshot", "wounds", "in", "the", "head", "and", "neck", "region", "are", "complicated", ".", "Two", "cases", "of", "such", "injuries", "in", "the", "head", "and", "neck", "region", "are", "introduced", "and", "therapeutic", "approaches", "are", "discussed", ".", "If", "there", "are", "no", "severe", "additional", "injuries", ",", "the", "treatment", "of", "choice", "is", "the", "endoscopic", "removal", "of", "the", "projectile", ".", "Alternatively", ",", "the", "projectile", "has", "to", "be", "taken", "out", "by", "conventional", "surgery", ",", "using", "the", "approach", "which", "induces", "the", "least", "stress", "for", "the", "patient", "." ]	[ "umlsterm" ]
gunshot wounds is an umlsterm, head is an umlsterm, neck is an umlsterm, injuries is an umlsterm, head is an umlsterm, neck is an umlsterm, therapeutic is an umlsterm, injuries is an umlsterm, treatment is an umlsterm, choice is an umlsterm, conventional surgery is an umlsterm, stress is an umlsterm, patient is an umlsterm	MundKieferGesichtschirurgie.90030102.eng.abstr_task1	Sentence: Internal gunshot wounds in the head and neck region are complicated . Two cases of such injuries in the head and neck region are introduced and therapeutic approaches are discussed . If there are no severe additional injuries , the treatment of choice is the endoscopic removal of the projectile . Alternatively , the projectile has to be taken out by conventional surgery , using the approach which induces the least stress for the patient . Instructions: please typing these entity words according to sentence: gunshot wounds, head, neck, injuries, head, neck, therapeutic, injuries, treatment, choice, conventional surgery, stress, patient Options: umlsterm	[ "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]	Internal gunshot wounds in the head and neck region are complicated . Two cases of such injuries in the head and neck region are introduced and therapeutic approaches are discussed . If there are no severe additional injuries , the treatment of choice is the endoscopic removal of the projectile . Alternatively , the projectile has to be taken out by conventional surgery , using the approach which induces the least stress for the patient .	[ "Internal", "gunshot", "wounds", "in", "the", "head", "and", "neck", "region", "are", "complicated", ".", "Two", "cases", "of", "such", "injuries", "in", "the", "head", "and", "neck", "region", "are", "introduced", "and", "therapeutic", "approaches", "are", "discussed", ".", "If", "there", "are", "no", "severe", "additional", "injuries", ",", "the", "treatment", "of", "choice", "is", "the", "endoscopic", "removal", "of", "the", "projectile", ".", "Alternatively", ",", "the", "projectile", "has", "to", "be", "taken", "out", "by", "conventional", "surgery", ",", "using", "the", "approach", "which", "induces", "the", "least", "stress", "for", "the", "patient", "." ]	[ "umlsterm" ]
gunshot wounds, head, neck, injuries, head, neck, therapeutic, injuries, treatment, choice, conventional surgery, stress, patient	MundKieferGesichtschirurgie.90030102.eng.abstr_task2	Sentence: Internal gunshot wounds in the head and neck region are complicated . Two cases of such injuries in the head and neck region are introduced and therapeutic approaches are discussed . If there are no severe additional injuries , the treatment of choice is the endoscopic removal of the projectile . Alternatively , the projectile has to be taken out by conventional surgery , using the approach which induces the least stress for the patient . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]	Internal gunshot wounds in the head and neck region are complicated . Two cases of such injuries in the head and neck region are introduced and therapeutic approaches are discussed . If there are no severe additional injuries , the treatment of choice is the endoscopic removal of the projectile . Alternatively , the projectile has to be taken out by conventional surgery , using the approach which induces the least stress for the patient .	[ "Internal", "gunshot", "wounds", "in", "the", "head", "and", "neck", "region", "are", "complicated", ".", "Two", "cases", "of", "such", "injuries", "in", "the", "head", "and", "neck", "region", "are", "introduced", "and", "therapeutic", "approaches", "are", "discussed", ".", "If", "there", "are", "no", "severe", "additional", "injuries", ",", "the", "treatment", "of", "choice", "is", "the", "endoscopic", "removal", "of", "the", "projectile", ".", "Alternatively", ",", "the", "projectile", "has", "to", "be", "taken", "out", "by", "conventional", "surgery", ",", "using", "the", "approach", "which", "induces", "the", "least", "stress", "for", "the", "patient", "." ]	[ "umlsterm" ]
tumor is a MORFOLOGIA_NEOPLASIA, tumoral is a MORFOLOGIA_NEOPLASIA, timoma tipo B1 is a MORFOLOGIA_NEOPLASIA, progresión pleural is a MORFOLOGIA_NEOPLASIA, lesiones pleurales is a MORFOLOGIA_NEOPLASIA, enfermedad a nivel pleural is a MORFOLOGIA_NEOPLASIA, enfermedad locorregional y pleural is a MORFOLOGIA_NEOPLASIA, timoma tipo B2 invasor is a MORFOLOGIA_NEOPLASIA, progresión a nivel pleuropulmonar is a MORFOLOGIA_NEOPLASIA, implantes intraabdominales is a MORFOLOGIA_NEOPLASIA, timoma is a MORFOLOGIA_NEOPLASIA, tumor is a MORFOLOGIA_NEOPLASIA	391_task0	Sentence: Anamnesis Mujer de 39 años, sin antecedentes de interés. En diciembre de 2012 inicia estudio en su país de origen por cuadro de disnea de un año de evolución asociado a dolor torácico. La TC objetiva un tumor de 92 x 74 mm que ocupa el mediastino anterior y que invade pericardio, porción ascendente del cayado aórtico y tronco de la arteria pulmonar. Se realiza resección tumoral parcial en enero de 2013, obteniendo el diagnóstico anatomopatológico de timoma tipo B1 con infiltración capsular. Posteriormente, la paciente es derivada a consultas de Oncología, donde se plantea quimioterapia complementaria según esquema Descripción epirrubicina-"platamina", del que recibe 4 ciclos (último en mayo 2013). Tras progresión locorregional en septiembre 2013 y tras haber comentado caso en comité de tumores torácicos, se decide tratamiento con quimio-radioterapia concomitante con cisplatino (21 sesiones de radioterapia). Posteriormente la paciente inicia seguimiento y se traslada a nuestro país. En agosto de 2014 presenta nueva progresión pleural y pararrenal izquierda, iniciando nueva línea de tratamiento según esquema Ifosfamida 1,5 mg/m2 durante 5 días, del que sólo pudo recibir un ciclo por neutropenia grado IV mantenida, requiriendo modificar esquema a TAXOL semanal (2 on y 1 off) y del que recibe 6 ciclos con estabilización de la enfermedad. Posteriormente se realiza radioterapia de consolidación sobre lesiones pleurales y pararrenal izquierda, finalizando el tratamiento en agosto 2015. En marzo de 2016 se evidencia en TC nueva recaída de la enfermedad a nivel pleural y se reinicia TAXOL semanal, recibiendo sólo 3 ciclos por presentar de nuevo toxicidad hematológica. Mantiene estabilidad de la enfermedad hasta enero de 2017, donde progresa de nuevo a nivel pleural y ganglionar. Ante el antecedente de toxicidad previa, se inicia tratamiento con pemetrexed 500 mg/m2 día 1 cada 21 días, recibiendo un total de 6 ciclos desde marzo a septiembre 2017 e iniciando de nuevo seguimiento (se decide stop de tratamiento por estabilidad de la enfermedad y toxicidad acumulada). En diciembre 2017 se evidencia progresión de la enfermedad locorregional y pleural comentándose caso en comité de tumores y decidiéndose resección parcial de la enfermedad, que se realiza en febrero 2018. La Anatomía Patológica fue de timoma tipo B2 invasor con alto índice proliferativo (Ki 67 de 40-50 %) y alta expresión de PDL1 (80 %). Tras la cirugía, la enfermedad se mantendría estable hasta septiembre de 2018, donde se objetiva nueva progresión a nivel pleuropulmonar, pararrenal y nuevos implantes intraabdominales. Se vuelve a comentar caso en sesión y ante hallazgos de Anatomía Patológica y toxicidad previa a quimioterapia, se solicita inmunoterapia con nivolumab como uso compasivo, iniciando ciclo 1 el 26 de septiembre de 2018. El día 5 de octubre consulta en el Servicio de Urgencias por cuadro de 3-4 días de evolución de astenia, debilidad muscular proximal, ptosis y diplopía. Exploración física » Consciente, orientada, afebril, eupneica en reposo. » NRL: funciones superiores conservadas. Pupilas "normocóricas" y normorreactivas, ptosis bilateral, oftalmoparesia para la aducción de ambos rectos internos en mirada lateral. » Balance motor: deltoides basal 4+/5 bilateral, tras 10 repeticiones fatiga y 4-/5 derecho y 3/5 izquierdo. Flexores de cuello basal 4/5, tras 5 repeticiones 3-/5. » Test del hielo en consulta positivo: mejoría notable de la oftalmoparesia y la ptosis. Pruebas complementarias » » Analítica con bioquímica, hemograma y coagulación rigurosamente normal. » » Se realiza TC de cráneo en el que no se objetivan hallazgos patológicos. » Se extrae analítica para estudio de perfil autoinmune (anticuerpos anti-AChR, anti-Musk y anti-músculo estriado). Diagnóstico Sospecha de miastenia gravis en paciente con timoma tras primer ciclo de nivolumab. Tratamiento » Piridostigmina 60 mg cada 8 horas. » Prednisona 60 mg cada 24 horas. Evolución Tras alta a domicilio con piridostigmina y corticoides, la paciente consulta de nuevo en Urgencias a los 5 días por el mismo cuadro, asociando, además, disnea y tos de 24-48 horas de evolución, sin fiebre. Se realiza angio-TC de tórax, la cual descarta progresión de la enfermedad, TEP, neumonía o neumonitis por toxicidad a inmunoterapia. Se traslada a sala de observación para iniciar tratamiento intravenoso con inmunoglobulinas y, ante la no mejoría del cuadro y la inestabilización de la paciente, termina ingresando en UCI. La paciente requiere intubación orotraqueal y tratamiento mediante plasmaféresis. Tras la primera semana, en la que no se había obtenido respuesta al tratamiento, se reciben los resultados de los anticuerpos solicitados: anti-AChR > 20 (0-0,45) y anti-Musk < 0,4 (0-0,4). En aquel momento se considera el diagnóstico de crisis miasténica Osserman grado 5 en relación a síndrome paraneoplásico del tumor primario, por lo que se presenta el caso en comité de tumores y se decide iniciar quimioterapia según esquema cisplatino, doxorrubicina y ciclofosfamida (CAP). Tras el primer ciclo, parece existir una ligera respuesta durante las primeras 48 horas. Sin embargo, y a pesar de un segundo ciclo de tratamiento, el cuadro continuaría progresando hasta finalmente producir la muerte de la paciente tras 38 días de ingreso en UCI. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: MORFOLOGIA_NEOPLASIA	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Anamnesis Mujer de 39 años, sin antecedentes de interés. En diciembre de 2012 inicia estudio en su país de origen por cuadro de disnea de un año de evolución asociado a dolor torácico. La TC objetiva un tumor de 92 x 74 mm que ocupa el mediastino anterior y que invade pericardio, porción ascendente del cayado aórtico y tronco de la arteria pulmonar. Se realiza resección tumoral parcial en enero de 2013, obteniendo el diagnóstico anatomopatológico de timoma tipo B1 con infiltración capsular. Posteriormente, la paciente es derivada a consultas de Oncología, donde se plantea quimioterapia complementaria según esquema Descripción epirrubicina-"platamina", del que recibe 4 ciclos (último en mayo 2013). Tras progresión locorregional en septiembre 2013 y tras haber comentado caso en comité de tumores torácicos, se decide tratamiento con quimio-radioterapia concomitante con cisplatino (21 sesiones de radioterapia). Posteriormente la paciente inicia seguimiento y se traslada a nuestro país. En agosto de 2014 presenta nueva progresión pleural y pararrenal izquierda, iniciando nueva línea de tratamiento según esquema Ifosfamida 1,5 mg/m2 durante 5 días, del que sólo pudo recibir un ciclo por neutropenia grado IV mantenida, requiriendo modificar esquema a TAXOL semanal (2 on y 1 off) y del que recibe 6 ciclos con estabilización de la enfermedad. Posteriormente se realiza radioterapia de consolidación sobre lesiones pleurales y pararrenal izquierda, finalizando el tratamiento en agosto 2015. En marzo de 2016 se evidencia en TC nueva recaída de la enfermedad a nivel pleural y se reinicia TAXOL semanal, recibiendo sólo 3 ciclos por presentar de nuevo toxicidad hematológica. Mantiene estabilidad de la enfermedad hasta enero de 2017, donde progresa de nuevo a nivel pleural y ganglionar. Ante el antecedente de toxicidad previa, se inicia tratamiento con pemetrexed 500 mg/m2 día 1 cada 21 días, recibiendo un total de 6 ciclos desde marzo a septiembre 2017 e iniciando de nuevo seguimiento (se decide stop de tratamiento por estabilidad de la enfermedad y toxicidad acumulada). En diciembre 2017 se evidencia progresión de la enfermedad locorregional y pleural comentándose caso en comité de tumores y decidiéndose resección parcial de la enfermedad, que se realiza en febrero 2018. La Anatomía Patológica fue de timoma tipo B2 invasor con alto índice proliferativo (Ki 67 de 40-50 %) y alta expresión de PDL1 (80 %). Tras la cirugía, la enfermedad se mantendría estable hasta septiembre de 2018, donde se objetiva nueva progresión a nivel pleuropulmonar, pararrenal y nuevos implantes intraabdominales. Se vuelve a comentar caso en sesión y ante hallazgos de Anatomía Patológica y toxicidad previa a quimioterapia, se solicita inmunoterapia con nivolumab como uso compasivo, iniciando ciclo 1 el 26 de septiembre de 2018. El día 5 de octubre consulta en el Servicio de Urgencias por cuadro de 3-4 días de evolución de astenia, debilidad muscular proximal, ptosis y diplopía. Exploración física » Consciente, orientada, afebril, eupneica en reposo. » NRL: funciones superiores conservadas. Pupilas "normocóricas" y normorreactivas, ptosis bilateral, oftalmoparesia para la aducción de ambos rectos internos en mirada lateral. » Balance motor: deltoides basal 4+/5 bilateral, tras 10 repeticiones fatiga y 4-/5 derecho y 3/5 izquierdo. Flexores de cuello basal 4/5, tras 5 repeticiones 3-/5. » Test del hielo en consulta positivo: mejoría notable de la oftalmoparesia y la ptosis. Pruebas complementarias » » Analítica con bioquímica, hemograma y coagulación rigurosamente normal. » » Se realiza TC de cráneo en el que no se objetivan hallazgos patológicos. » Se extrae analítica para estudio de perfil autoinmune (anticuerpos anti-AChR, anti-Musk y anti-músculo estriado). Diagnóstico Sospecha de miastenia gravis en paciente con timoma tras primer ciclo de nivolumab. Tratamiento » Piridostigmina 60 mg cada 8 horas. » Prednisona 60 mg cada 24 horas. Evolución Tras alta a domicilio con piridostigmina y corticoides, la paciente consulta de nuevo en Urgencias a los 5 días por el mismo cuadro, asociando, además, disnea y tos de 24-48 horas de evolución, sin fiebre. Se realiza angio-TC de tórax, la cual descarta progresión de la enfermedad, TEP, neumonía o neumonitis por toxicidad a inmunoterapia. Se traslada a sala de observación para iniciar tratamiento intravenoso con inmunoglobulinas y, ante la no mejoría del cuadro y la inestabilización de la paciente, termina ingresando en UCI. La paciente requiere intubación orotraqueal y tratamiento mediante plasmaféresis. Tras la primera semana, en la que no se había obtenido respuesta al tratamiento, se reciben los resultados de los anticuerpos solicitados: anti-AChR > 20 (0-0,45) y anti-Musk < 0,4 (0-0,4). En aquel momento se considera el diagnóstico de crisis miasténica Osserman grado 5 en relación a síndrome paraneoplásico del tumor primario, por lo que se presenta el caso en comité de tumores y se decide iniciar quimioterapia según esquema cisplatino, doxorrubicina y ciclofosfamida (CAP). Tras el primer ciclo, parece existir una ligera respuesta durante las primeras 48 horas. Sin embargo, y a pesar de un segundo ciclo de tratamiento, el cuadro continuaría progresando hasta finalmente producir la muerte de la paciente tras 38 días de ingreso en UCI.	[ "Anamnesis", "\n", "Mujer", "de", "39", "años", ",", "sin", "antecedentes", "de", "interés", ".", "\n", "En", "diciembre", "de", "2012", "inicia", "estudio", "en", "su", "país", "de", "origen", "por", "cuadro", "de", "disnea", "de", "un", "año", "de", "evolución", "asociado", "a", "dolor", "torácico", ".", "La", "TC", "objetiva", "un", "tumor", "de", "92", "x", "74", "mm", "que", "ocupa", "el", "mediastino", "anterior", "y", "que", "invade", "pericardio", ",", "porción", "ascendente", "del", "cayado", "aórtico", "y", "tronco", "de", "la", "arteria", "pulmonar", ".", "Se", "realiza", "resección", "tumoral", "parcial", "en", "enero", "de", "2013", ",", "obteniendo", "el", "diagnóstico", "anatomopatológico", "de", "timoma", "tipo", "B1", "con", "infiltración", "capsular", ".", "\n", "Posteriormente", ",", "la", "paciente", "es", "derivada", "a", "consultas", "de", "Oncología", ",", "donde", "se", "plantea", "quimioterapia", "complementaria", "según", "esquema", "Descripción", "epirrubicina-\"platamina", "\"", ",", "del", "que", "recibe", "4", "ciclos", "(", "último", "en", "mayo", "2013", ")", ".", "\n", "Tras", "progresión", "locorregional", "en", "septiembre", "2013", "y", "tras", "haber", "comentado", "caso", "en", "comité", "de", "tumores", "torácicos", ",", "se", "decide", "tratamiento", "con", "quimio", "-", "radioterapia", "concomitante", "con", "cisplatino", "(", "21", "sesiones", "de", "radioterapia", ")", ".", "Posteriormente", "la", "paciente", "inicia", "seguimiento", "y", "se", "traslada", "a", "nuestro", "país", ".", "\n", "En", "agosto", "de", "2014", "presenta", "nueva", "progresión", "pleural", "y", "pararrenal", "izquierda", ",", "iniciando", "nueva", "línea", "de", "tratamiento", "según", "esquema", "Ifosfamida", "1,5", "mg", "/", "m2", "durante", "5", "días", ",", "del", "que", "sólo", "pudo", "recibir", "un", "ciclo", "por", "neutropenia", "grado", "IV", "mantenida", ",", "requiriendo", "modificar", "esquema", "a", "TAXOL", "semanal", "(", "2", "on", "y", "1", "off", ")", "y", "del", "que", "recibe", "6", "ciclos", "con", "estabilización", "de", "la", "enfermedad", ".", "Posteriormente", "se", "realiza", "radioterapia", "de", "consolidación", "sobre", "lesiones", "pleurales", "y", "pararrenal", "izquierda", ",", "finalizando", "el", "tratamiento", "en", "agosto", "2015", ".", "\n", "En", "marzo", "de", "2016", "se", "evidencia", "en", "TC", "nueva", "recaída", "de", "la", "enfermedad", "a", "nivel", "pleural", "y", "se", "reinicia", "TAXOL", "semanal", ",", "recibiendo", "sólo", "3", "ciclos", "por", "presentar", "de", "nuevo", "toxicidad", "hematológica", ".", "Mantiene", "estabilidad", "de", "la", "enfermedad", "hasta", "enero", "de", "2017", ",", "donde", "progresa", "de", "nuevo", "a", "nivel", "pleural", "y", "ganglionar", ".", "Ante", "el", "antecedente", "de", "toxicidad", "previa", ",", "se", "inicia", "tratamiento", "con", "pemetrexed", "500", "mg", "/", "m2", "día", "1", "cada", "21", "días", ",", "recibiendo", "un", "total", "de", "6", "ciclos", "desde", "marzo", "a", "septiembre", "2017", "e", "iniciando", "de", "nuevo", "seguimiento", "(", "se", "decide", "stop", "de", "tratamiento", "por", "estabilidad", "de", "la", "enfermedad", "y", "toxicidad", "acumulada", ")", ".", "\n", "En", "diciembre", "2017", "se", "evidencia", "progresión", "de", "la", "enfermedad", "locorregional", "y", "pleural", "comentándose", "caso", "en", "comité", "de", "tumores", "y", "decidiéndose", "resección", "parcial", "de", "la", "enfermedad", ",", "que", "se", "realiza", "en", "febrero", "2018", ".", "La", "Anatomía", "Patológica", "fue", "de", "timoma", "tipo", "B2", "invasor", "con", "alto", "índice", "proliferativo", "(", "Ki", "67", "de", "40", "-", "50", "%", ")", "y", "alta", "expresión", "de", "PDL1", "(", "80", "%", ")", ".", "\n", "Tras", "la", "cirugía", ",", "la", "enfermedad", "se", "mantendría", "estable", "hasta", "septiembre", "de", "2018", ",", "donde", "se", "objetiva", "nueva", "progresión", "a", "nivel", "pleuropulmonar", ",", "pararrenal", "y", "nuevos", "implantes", "intraabdominales", ".", "Se", "vuelve", "a", "comentar", "caso", "en", "sesión", "y", "ante", "hallazgos", "de", "Anatomía", "Patológica", "y", "toxicidad", "previa", "a", "quimioterapia", ",", "se", "solicita", "inmunoterapia", "con", "nivolumab", "como", "uso", "compasivo", ",", "iniciando", "ciclo", "1", "el", "26", "de", "septiembre", "de", "2018", ".", "\n", "El", "día", "5", "de", "octubre", "consulta", "en", "el", "Servicio", "de", "Urgencias", "por", "cuadro", "de", "3", "-", "4", "días", "de", "evolución", "de", "astenia", ",", "debilidad", "muscular", "proximal", ",", "ptosis", "y", "diplopía", ".", "\n\n", "Exploración", "física", "\n", "»", "Consciente", ",", "orientada", ",", "afebril", ",", "eupneica", "en", "reposo", ".", "\n", "»", "NRL", ":", "funciones", "superiores", "conservadas", ".", "Pupilas", "\"", "normocóricas", "\"", "y", "normorreactivas", ",", "ptosis", "bilateral", ",", "oftalmoparesia", "para", "la", "aducción", "de", "ambos", "rectos", "internos", "en", "mirada", "lateral", ".", "\n", "»", "Balance", "motor", ":", "deltoides", "basal", "4+/5", "bilateral", ",", "tras", "10", "repeticiones", "fatiga", "y", "4-/5", "derecho", "y", "3/5", "izquierdo", ".", "Flexores", "de", "cuello", "basal", "4/5", ",", "tras", "5", "repeticiones", "3-/5", ".", "\n", "»", "Test", "del", "hielo", "en", "consulta", "positivo", ":", "mejoría", "notable", "de", "la", "oftalmoparesia", "y", "la", "ptosis", ".", "\n\n", "Pruebas", "complementarias", "\n", "»", "»", "Analítica", "con", "bioquímica", ",", "hemograma", "y", "coagulación", "rigurosamente", "normal", ".", "\n", "»", "»", "Se", "realiza", "TC", "de", "cráneo", "en", "el", "que", "no", "se", "objetivan", "hallazgos", "patológicos", ".", "\n", "»", "Se", "extrae", "analítica", "para", "estudio", "de", "perfil", "autoinmune", "(", "anticuerpos", "anti", "-", "AChR", ",", "anti", "-", "Musk", "y", "anti", "-", "músculo", "estriado", ")", ".", "\n\n", "Diagnóstico", "\n", "Sospecha", "de", "miastenia", "gravis", "en", "paciente", "con", "timoma", "tras", "primer", "ciclo", "de", "nivolumab", ".", "\n\n", "Tratamiento", "\n", "»", "Piridostigmina", "60", "mg", "cada", "8", "horas", ".", "\n", "»", "Prednisona", "60", "mg", "cada", "24", "horas", ".", "\n\n", "Evolución", "\n", "Tras", "alta", "a", "domicilio", "con", "piridostigmina", "y", "corticoides", ",", "la", "paciente", "consulta", "de", "nuevo", "en", "Urgencias", "a", "los", "5", "días", "por", "el", "mismo", "cuadro", ",", "asociando", ",", "además", ",", "disnea", "y", "tos", "de", "24", "-", "48", "horas", "de", "evolución", ",", "sin", "fiebre", ".", "Se", "realiza", "angio", "-", "TC", "de", "tórax", ",", "la", "cual", "descarta", "progresión", "de", "la", "enfermedad", ",", "TEP", ",", "neumonía", "o", "neumonitis", "por", "toxicidad", "a", "inmunoterapia", ".", "Se", "traslada", "a", "sala", "de", "observación", "para", "iniciar", "tratamiento", "intravenoso", "con", "inmunoglobulinas", "y", ",", "ante", "la", "no", "mejoría", "del", "cuadro", "y", "la", "inestabilización", "de", "la", "paciente", ",", "termina", "ingresando", "en", "UCI", ".", "\n", "La", "paciente", "requiere", "intubación", "orotraqueal", "y", "tratamiento", "mediante", "plasmaféresis", ".", "Tras", "la", "primera", "semana", ",", "en", "la", "que", "no", "se", "había", "obtenido", "respuesta", "al", "tratamiento", ",", "se", "reciben", "los", "resultados", "de", "los", "anticuerpos", "solicitados", ":", "anti", "-", "AChR", ">", "20", "(", "0", "-", "0,45", ")", "y", "anti", "-", "Musk", "<", "0,4", "(", "0", "-", "0,4", ")", ".", "\n", "En", "aquel", "momento", "se", "considera", "el", "diagnóstico", "de", "crisis", "miasténica", "Osserman", "grado", "5", "en", "relación", "a", "síndrome", "paraneoplásico", "del", "tumor", "primario", ",", "por", "lo", "que", "se", "presenta", "el", "caso", "en", "comité", "de", "tumores", "y", "se", "decide", "iniciar", "quimioterapia", "según", "esquema", "cisplatino", ",", "doxorrubicina", "y", "ciclofosfamida", "(", "CAP", ")", ".", "\n", "Tras", "el", "primer", "ciclo", ",", "parece", "existir", "una", "ligera", "respuesta", "durante", "las", "primeras", "48", "horas", ".", "Sin", "embargo", ",", "y", "a", "pesar", "de", "un", "segundo", "ciclo", "de", "tratamiento", ",", "el", "cuadro", "continuaría", "progresando", "hasta", "finalmente", "producir", "la", "muerte", "de", "la", "paciente", "tras", "38", "días", "de", "ingreso", "en", "UCI", "." ]	[ "MORFOLOGIA_NEOPLASIA" ]
tumor is a MORFOLOGIA_NEOPLASIA, tumoral is a MORFOLOGIA_NEOPLASIA, timoma tipo B1 is a MORFOLOGIA_NEOPLASIA, progresión pleural is a MORFOLOGIA_NEOPLASIA, lesiones pleurales is a MORFOLOGIA_NEOPLASIA, enfermedad a nivel pleural is a MORFOLOGIA_NEOPLASIA, enfermedad locorregional y pleural is a MORFOLOGIA_NEOPLASIA, timoma tipo B2 invasor is a MORFOLOGIA_NEOPLASIA, progresión a nivel pleuropulmonar is a MORFOLOGIA_NEOPLASIA, implantes intraabdominales is a MORFOLOGIA_NEOPLASIA, timoma is a MORFOLOGIA_NEOPLASIA, tumor is a MORFOLOGIA_NEOPLASIA	391_task1	Sentence: Anamnesis Mujer de 39 años, sin antecedentes de interés. En diciembre de 2012 inicia estudio en su país de origen por cuadro de disnea de un año de evolución asociado a dolor torácico. La TC objetiva un tumor de 92 x 74 mm que ocupa el mediastino anterior y que invade pericardio, porción ascendente del cayado aórtico y tronco de la arteria pulmonar. Se realiza resección tumoral parcial en enero de 2013, obteniendo el diagnóstico anatomopatológico de timoma tipo B1 con infiltración capsular. Posteriormente, la paciente es derivada a consultas de Oncología, donde se plantea quimioterapia complementaria según esquema Descripción epirrubicina-"platamina", del que recibe 4 ciclos (último en mayo 2013). Tras progresión locorregional en septiembre 2013 y tras haber comentado caso en comité de tumores torácicos, se decide tratamiento con quimio-radioterapia concomitante con cisplatino (21 sesiones de radioterapia). Posteriormente la paciente inicia seguimiento y se traslada a nuestro país. En agosto de 2014 presenta nueva progresión pleural y pararrenal izquierda, iniciando nueva línea de tratamiento según esquema Ifosfamida 1,5 mg/m2 durante 5 días, del que sólo pudo recibir un ciclo por neutropenia grado IV mantenida, requiriendo modificar esquema a TAXOL semanal (2 on y 1 off) y del que recibe 6 ciclos con estabilización de la enfermedad. Posteriormente se realiza radioterapia de consolidación sobre lesiones pleurales y pararrenal izquierda, finalizando el tratamiento en agosto 2015. En marzo de 2016 se evidencia en TC nueva recaída de la enfermedad a nivel pleural y se reinicia TAXOL semanal, recibiendo sólo 3 ciclos por presentar de nuevo toxicidad hematológica. Mantiene estabilidad de la enfermedad hasta enero de 2017, donde progresa de nuevo a nivel pleural y ganglionar. Ante el antecedente de toxicidad previa, se inicia tratamiento con pemetrexed 500 mg/m2 día 1 cada 21 días, recibiendo un total de 6 ciclos desde marzo a septiembre 2017 e iniciando de nuevo seguimiento (se decide stop de tratamiento por estabilidad de la enfermedad y toxicidad acumulada). En diciembre 2017 se evidencia progresión de la enfermedad locorregional y pleural comentándose caso en comité de tumores y decidiéndose resección parcial de la enfermedad, que se realiza en febrero 2018. La Anatomía Patológica fue de timoma tipo B2 invasor con alto índice proliferativo (Ki 67 de 40-50 %) y alta expresión de PDL1 (80 %). Tras la cirugía, la enfermedad se mantendría estable hasta septiembre de 2018, donde se objetiva nueva progresión a nivel pleuropulmonar, pararrenal y nuevos implantes intraabdominales. Se vuelve a comentar caso en sesión y ante hallazgos de Anatomía Patológica y toxicidad previa a quimioterapia, se solicita inmunoterapia con nivolumab como uso compasivo, iniciando ciclo 1 el 26 de septiembre de 2018. El día 5 de octubre consulta en el Servicio de Urgencias por cuadro de 3-4 días de evolución de astenia, debilidad muscular proximal, ptosis y diplopía. Exploración física » Consciente, orientada, afebril, eupneica en reposo. » NRL: funciones superiores conservadas. Pupilas "normocóricas" y normorreactivas, ptosis bilateral, oftalmoparesia para la aducción de ambos rectos internos en mirada lateral. » Balance motor: deltoides basal 4+/5 bilateral, tras 10 repeticiones fatiga y 4-/5 derecho y 3/5 izquierdo. Flexores de cuello basal 4/5, tras 5 repeticiones 3-/5. » Test del hielo en consulta positivo: mejoría notable de la oftalmoparesia y la ptosis. Pruebas complementarias » » Analítica con bioquímica, hemograma y coagulación rigurosamente normal. » » Se realiza TC de cráneo en el que no se objetivan hallazgos patológicos. » Se extrae analítica para estudio de perfil autoinmune (anticuerpos anti-AChR, anti-Musk y anti-músculo estriado). Diagnóstico Sospecha de miastenia gravis en paciente con timoma tras primer ciclo de nivolumab. Tratamiento » Piridostigmina 60 mg cada 8 horas. » Prednisona 60 mg cada 24 horas. Evolución Tras alta a domicilio con piridostigmina y corticoides, la paciente consulta de nuevo en Urgencias a los 5 días por el mismo cuadro, asociando, además, disnea y tos de 24-48 horas de evolución, sin fiebre. Se realiza angio-TC de tórax, la cual descarta progresión de la enfermedad, TEP, neumonía o neumonitis por toxicidad a inmunoterapia. Se traslada a sala de observación para iniciar tratamiento intravenoso con inmunoglobulinas y, ante la no mejoría del cuadro y la inestabilización de la paciente, termina ingresando en UCI. La paciente requiere intubación orotraqueal y tratamiento mediante plasmaféresis. Tras la primera semana, en la que no se había obtenido respuesta al tratamiento, se reciben los resultados de los anticuerpos solicitados: anti-AChR > 20 (0-0,45) y anti-Musk < 0,4 (0-0,4). En aquel momento se considera el diagnóstico de crisis miasténica Osserman grado 5 en relación a síndrome paraneoplásico del tumor primario, por lo que se presenta el caso en comité de tumores y se decide iniciar quimioterapia según esquema cisplatino, doxorrubicina y ciclofosfamida (CAP). Tras el primer ciclo, parece existir una ligera respuesta durante las primeras 48 horas. Sin embargo, y a pesar de un segundo ciclo de tratamiento, el cuadro continuaría progresando hasta finalmente producir la muerte de la paciente tras 38 días de ingreso en UCI. Instructions: please typing these entity words according to sentence: tumor, tumoral, timoma tipo B1, progresión pleural, lesiones pleurales, enfermedad a nivel pleural, enfermedad locorregional y pleural, timoma tipo B2 invasor, progresión a nivel pleuropulmonar, implantes intraabdominales, timoma, tumor Options: MORFOLOGIA_NEOPLASIA	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Anamnesis Mujer de 39 años, sin antecedentes de interés. En diciembre de 2012 inicia estudio en su país de origen por cuadro de disnea de un año de evolución asociado a dolor torácico. La TC objetiva un tumor de 92 x 74 mm que ocupa el mediastino anterior y que invade pericardio, porción ascendente del cayado aórtico y tronco de la arteria pulmonar. Se realiza resección tumoral parcial en enero de 2013, obteniendo el diagnóstico anatomopatológico de timoma tipo B1 con infiltración capsular. Posteriormente, la paciente es derivada a consultas de Oncología, donde se plantea quimioterapia complementaria según esquema Descripción epirrubicina-"platamina", del que recibe 4 ciclos (último en mayo 2013). Tras progresión locorregional en septiembre 2013 y tras haber comentado caso en comité de tumores torácicos, se decide tratamiento con quimio-radioterapia concomitante con cisplatino (21 sesiones de radioterapia). Posteriormente la paciente inicia seguimiento y se traslada a nuestro país. En agosto de 2014 presenta nueva progresión pleural y pararrenal izquierda, iniciando nueva línea de tratamiento según esquema Ifosfamida 1,5 mg/m2 durante 5 días, del que sólo pudo recibir un ciclo por neutropenia grado IV mantenida, requiriendo modificar esquema a TAXOL semanal (2 on y 1 off) y del que recibe 6 ciclos con estabilización de la enfermedad. Posteriormente se realiza radioterapia de consolidación sobre lesiones pleurales y pararrenal izquierda, finalizando el tratamiento en agosto 2015. En marzo de 2016 se evidencia en TC nueva recaída de la enfermedad a nivel pleural y se reinicia TAXOL semanal, recibiendo sólo 3 ciclos por presentar de nuevo toxicidad hematológica. Mantiene estabilidad de la enfermedad hasta enero de 2017, donde progresa de nuevo a nivel pleural y ganglionar. Ante el antecedente de toxicidad previa, se inicia tratamiento con pemetrexed 500 mg/m2 día 1 cada 21 días, recibiendo un total de 6 ciclos desde marzo a septiembre 2017 e iniciando de nuevo seguimiento (se decide stop de tratamiento por estabilidad de la enfermedad y toxicidad acumulada). En diciembre 2017 se evidencia progresión de la enfermedad locorregional y pleural comentándose caso en comité de tumores y decidiéndose resección parcial de la enfermedad, que se realiza en febrero 2018. La Anatomía Patológica fue de timoma tipo B2 invasor con alto índice proliferativo (Ki 67 de 40-50 %) y alta expresión de PDL1 (80 %). Tras la cirugía, la enfermedad se mantendría estable hasta septiembre de 2018, donde se objetiva nueva progresión a nivel pleuropulmonar, pararrenal y nuevos implantes intraabdominales. Se vuelve a comentar caso en sesión y ante hallazgos de Anatomía Patológica y toxicidad previa a quimioterapia, se solicita inmunoterapia con nivolumab como uso compasivo, iniciando ciclo 1 el 26 de septiembre de 2018. El día 5 de octubre consulta en el Servicio de Urgencias por cuadro de 3-4 días de evolución de astenia, debilidad muscular proximal, ptosis y diplopía. Exploración física » Consciente, orientada, afebril, eupneica en reposo. » NRL: funciones superiores conservadas. Pupilas "normocóricas" y normorreactivas, ptosis bilateral, oftalmoparesia para la aducción de ambos rectos internos en mirada lateral. » Balance motor: deltoides basal 4+/5 bilateral, tras 10 repeticiones fatiga y 4-/5 derecho y 3/5 izquierdo. Flexores de cuello basal 4/5, tras 5 repeticiones 3-/5. » Test del hielo en consulta positivo: mejoría notable de la oftalmoparesia y la ptosis. Pruebas complementarias » » Analítica con bioquímica, hemograma y coagulación rigurosamente normal. » » Se realiza TC de cráneo en el que no se objetivan hallazgos patológicos. » Se extrae analítica para estudio de perfil autoinmune (anticuerpos anti-AChR, anti-Musk y anti-músculo estriado). Diagnóstico Sospecha de miastenia gravis en paciente con timoma tras primer ciclo de nivolumab. Tratamiento » Piridostigmina 60 mg cada 8 horas. » Prednisona 60 mg cada 24 horas. Evolución Tras alta a domicilio con piridostigmina y corticoides, la paciente consulta de nuevo en Urgencias a los 5 días por el mismo cuadro, asociando, además, disnea y tos de 24-48 horas de evolución, sin fiebre. Se realiza angio-TC de tórax, la cual descarta progresión de la enfermedad, TEP, neumonía o neumonitis por toxicidad a inmunoterapia. Se traslada a sala de observación para iniciar tratamiento intravenoso con inmunoglobulinas y, ante la no mejoría del cuadro y la inestabilización de la paciente, termina ingresando en UCI. La paciente requiere intubación orotraqueal y tratamiento mediante plasmaféresis. Tras la primera semana, en la que no se había obtenido respuesta al tratamiento, se reciben los resultados de los anticuerpos solicitados: anti-AChR > 20 (0-0,45) y anti-Musk < 0,4 (0-0,4). En aquel momento se considera el diagnóstico de crisis miasténica Osserman grado 5 en relación a síndrome paraneoplásico del tumor primario, por lo que se presenta el caso en comité de tumores y se decide iniciar quimioterapia según esquema cisplatino, doxorrubicina y ciclofosfamida (CAP). Tras el primer ciclo, parece existir una ligera respuesta durante las primeras 48 horas. Sin embargo, y a pesar de un segundo ciclo de tratamiento, el cuadro continuaría progresando hasta finalmente producir la muerte de la paciente tras 38 días de ingreso en UCI.	[ "Anamnesis", "\n", "Mujer", "de", "39", "años", ",", "sin", "antecedentes", "de", "interés", ".", "\n", "En", "diciembre", "de", "2012", "inicia", "estudio", "en", "su", "país", "de", "origen", "por", "cuadro", "de", "disnea", "de", "un", "año", "de", "evolución", "asociado", "a", "dolor", "torácico", ".", "La", "TC", "objetiva", "un", "tumor", "de", "92", "x", "74", "mm", "que", "ocupa", "el", "mediastino", "anterior", "y", "que", "invade", "pericardio", ",", "porción", "ascendente", "del", "cayado", "aórtico", "y", "tronco", "de", "la", "arteria", "pulmonar", ".", "Se", "realiza", "resección", "tumoral", "parcial", "en", "enero", "de", "2013", ",", "obteniendo", "el", "diagnóstico", "anatomopatológico", "de", "timoma", "tipo", "B1", "con", "infiltración", "capsular", ".", "\n", "Posteriormente", ",", "la", "paciente", "es", "derivada", "a", "consultas", "de", "Oncología", ",", "donde", "se", "plantea", "quimioterapia", "complementaria", "según", "esquema", "Descripción", "epirrubicina-\"platamina", "\"", ",", "del", "que", "recibe", "4", "ciclos", "(", "último", "en", "mayo", "2013", ")", ".", "\n", "Tras", "progresión", "locorregional", "en", "septiembre", "2013", "y", "tras", "haber", "comentado", "caso", "en", "comité", "de", "tumores", "torácicos", ",", "se", "decide", "tratamiento", "con", "quimio", "-", "radioterapia", "concomitante", "con", "cisplatino", "(", "21", "sesiones", "de", "radioterapia", ")", ".", "Posteriormente", "la", "paciente", "inicia", "seguimiento", "y", "se", "traslada", "a", "nuestro", "país", ".", "\n", "En", "agosto", "de", "2014", "presenta", "nueva", "progresión", "pleural", "y", "pararrenal", "izquierda", ",", "iniciando", "nueva", "línea", "de", "tratamiento", "según", "esquema", "Ifosfamida", "1,5", "mg", "/", "m2", "durante", "5", "días", ",", "del", "que", "sólo", "pudo", "recibir", "un", "ciclo", "por", "neutropenia", "grado", "IV", "mantenida", ",", "requiriendo", "modificar", "esquema", "a", "TAXOL", "semanal", "(", "2", "on", "y", "1", "off", ")", "y", "del", "que", "recibe", "6", "ciclos", "con", "estabilización", "de", "la", "enfermedad", ".", "Posteriormente", "se", "realiza", "radioterapia", "de", "consolidación", "sobre", "lesiones", "pleurales", "y", "pararrenal", "izquierda", ",", "finalizando", "el", "tratamiento", "en", "agosto", "2015", ".", "\n", "En", "marzo", "de", "2016", "se", "evidencia", "en", "TC", "nueva", "recaída", "de", "la", "enfermedad", "a", "nivel", "pleural", "y", "se", "reinicia", "TAXOL", "semanal", ",", "recibiendo", "sólo", "3", "ciclos", "por", "presentar", "de", "nuevo", "toxicidad", "hematológica", ".", "Mantiene", "estabilidad", "de", "la", "enfermedad", "hasta", "enero", "de", "2017", ",", "donde", "progresa", "de", "nuevo", "a", "nivel", "pleural", "y", "ganglionar", ".", "Ante", "el", "antecedente", "de", "toxicidad", "previa", ",", "se", "inicia", "tratamiento", "con", "pemetrexed", "500", "mg", "/", "m2", "día", "1", "cada", "21", "días", ",", "recibiendo", "un", "total", "de", "6", "ciclos", "desde", "marzo", "a", "septiembre", "2017", "e", "iniciando", "de", "nuevo", "seguimiento", "(", "se", "decide", "stop", "de", "tratamiento", "por", "estabilidad", "de", "la", "enfermedad", "y", "toxicidad", "acumulada", ")", ".", "\n", "En", "diciembre", "2017", "se", "evidencia", "progresión", "de", "la", "enfermedad", "locorregional", "y", "pleural", "comentándose", "caso", "en", "comité", "de", "tumores", "y", "decidiéndose", "resección", "parcial", "de", "la", "enfermedad", ",", "que", "se", "realiza", "en", "febrero", "2018", ".", "La", "Anatomía", "Patológica", "fue", "de", "timoma", "tipo", "B2", "invasor", "con", "alto", "índice", "proliferativo", "(", "Ki", "67", "de", "40", "-", "50", "%", ")", "y", "alta", "expresión", "de", "PDL1", "(", "80", "%", ")", ".", "\n", "Tras", "la", "cirugía", ",", "la", "enfermedad", "se", "mantendría", "estable", "hasta", "septiembre", "de", "2018", ",", "donde", "se", "objetiva", "nueva", "progresión", "a", "nivel", "pleuropulmonar", ",", "pararrenal", "y", "nuevos", "implantes", "intraabdominales", ".", "Se", "vuelve", "a", "comentar", "caso", "en", "sesión", "y", "ante", "hallazgos", "de", "Anatomía", "Patológica", "y", "toxicidad", "previa", "a", "quimioterapia", ",", "se", "solicita", "inmunoterapia", "con", "nivolumab", "como", "uso", "compasivo", ",", "iniciando", "ciclo", "1", "el", "26", "de", "septiembre", "de", "2018", ".", "\n", "El", "día", "5", "de", "octubre", "consulta", "en", "el", "Servicio", "de", "Urgencias", "por", "cuadro", "de", "3", "-", "4", "días", "de", "evolución", "de", "astenia", ",", "debilidad", "muscular", "proximal", ",", "ptosis", "y", "diplopía", ".", "\n\n", "Exploración", "física", "\n", "»", "Consciente", ",", "orientada", ",", "afebril", ",", "eupneica", "en", "reposo", ".", "\n", "»", "NRL", ":", "funciones", "superiores", "conservadas", ".", "Pupilas", "\"", "normocóricas", "\"", "y", "normorreactivas", ",", "ptosis", "bilateral", ",", "oftalmoparesia", "para", "la", "aducción", "de", "ambos", "rectos", "internos", "en", "mirada", "lateral", ".", "\n", "»", "Balance", "motor", ":", "deltoides", "basal", "4+/5", "bilateral", ",", "tras", "10", "repeticiones", "fatiga", "y", "4-/5", "derecho", "y", "3/5", "izquierdo", ".", "Flexores", "de", "cuello", "basal", "4/5", ",", "tras", "5", "repeticiones", "3-/5", ".", "\n", "»", "Test", "del", "hielo", "en", "consulta", "positivo", ":", "mejoría", "notable", "de", "la", "oftalmoparesia", "y", "la", "ptosis", ".", "\n\n", "Pruebas", "complementarias", "\n", "»", "»", "Analítica", "con", "bioquímica", ",", "hemograma", "y", "coagulación", "rigurosamente", "normal", ".", "\n", "»", "»", "Se", "realiza", "TC", "de", "cráneo", "en", "el", "que", "no", "se", "objetivan", "hallazgos", "patológicos", ".", "\n", "»", "Se", "extrae", "analítica", "para", "estudio", "de", "perfil", "autoinmune", "(", "anticuerpos", "anti", "-", "AChR", ",", "anti", "-", "Musk", "y", "anti", "-", "músculo", "estriado", ")", ".", "\n\n", "Diagnóstico", "\n", "Sospecha", "de", "miastenia", "gravis", "en", "paciente", "con", "timoma", "tras", "primer", "ciclo", "de", "nivolumab", ".", "\n\n", "Tratamiento", "\n", "»", "Piridostigmina", "60", "mg", "cada", "8", "horas", ".", "\n", "»", "Prednisona", "60", "mg", "cada", "24", "horas", ".", "\n\n", "Evolución", "\n", "Tras", "alta", "a", "domicilio", "con", "piridostigmina", "y", "corticoides", ",", "la", "paciente", "consulta", "de", "nuevo", "en", "Urgencias", "a", "los", "5", "días", "por", "el", "mismo", "cuadro", ",", "asociando", ",", "además", ",", "disnea", "y", "tos", "de", "24", "-", "48", "horas", "de", "evolución", ",", "sin", "fiebre", ".", "Se", "realiza", "angio", "-", "TC", "de", "tórax", ",", "la", "cual", "descarta", "progresión", "de", "la", "enfermedad", ",", "TEP", ",", "neumonía", "o", "neumonitis", "por", "toxicidad", "a", "inmunoterapia", ".", "Se", "traslada", "a", "sala", "de", "observación", "para", "iniciar", "tratamiento", "intravenoso", "con", "inmunoglobulinas", "y", ",", "ante", "la", "no", "mejoría", "del", "cuadro", "y", "la", "inestabilización", "de", "la", "paciente", ",", "termina", "ingresando", "en", "UCI", ".", "\n", "La", "paciente", "requiere", "intubación", "orotraqueal", "y", "tratamiento", "mediante", "plasmaféresis", ".", "Tras", "la", "primera", "semana", ",", "en", "la", "que", "no", "se", "había", "obtenido", "respuesta", "al", "tratamiento", ",", "se", "reciben", "los", "resultados", "de", "los", "anticuerpos", "solicitados", ":", "anti", "-", "AChR", ">", "20", "(", "0", "-", "0,45", ")", "y", "anti", "-", "Musk", "<", "0,4", "(", "0", "-", "0,4", ")", ".", "\n", "En", "aquel", "momento", "se", "considera", "el", "diagnóstico", "de", "crisis", "miasténica", "Osserman", "grado", "5", "en", "relación", "a", "síndrome", "paraneoplásico", "del", "tumor", "primario", ",", "por", "lo", "que", "se", "presenta", "el", "caso", "en", "comité", "de", "tumores", "y", "se", "decide", "iniciar", "quimioterapia", "según", "esquema", "cisplatino", ",", "doxorrubicina", "y", "ciclofosfamida", "(", "CAP", ")", ".", "\n", "Tras", "el", "primer", "ciclo", ",", "parece", "existir", "una", "ligera", "respuesta", "durante", "las", "primeras", "48", "horas", ".", "Sin", "embargo", ",", "y", "a", "pesar", "de", "un", "segundo", "ciclo", "de", "tratamiento", ",", "el", "cuadro", "continuaría", "progresando", "hasta", "finalmente", "producir", "la", "muerte", "de", "la", "paciente", "tras", "38", "días", "de", "ingreso", "en", "UCI", "." ]	[ "MORFOLOGIA_NEOPLASIA" ]
tumor, tumoral, timoma tipo B1, progresión pleural, lesiones pleurales, enfermedad a nivel pleural, enfermedad locorregional y pleural, timoma tipo B2 invasor, progresión a nivel pleuropulmonar, implantes intraabdominales, timoma, tumor	391_task2	Sentence: Anamnesis Mujer de 39 años, sin antecedentes de interés. En diciembre de 2012 inicia estudio en su país de origen por cuadro de disnea de un año de evolución asociado a dolor torácico. La TC objetiva un tumor de 92 x 74 mm que ocupa el mediastino anterior y que invade pericardio, porción ascendente del cayado aórtico y tronco de la arteria pulmonar. Se realiza resección tumoral parcial en enero de 2013, obteniendo el diagnóstico anatomopatológico de timoma tipo B1 con infiltración capsular. Posteriormente, la paciente es derivada a consultas de Oncología, donde se plantea quimioterapia complementaria según esquema Descripción epirrubicina-"platamina", del que recibe 4 ciclos (último en mayo 2013). Tras progresión locorregional en septiembre 2013 y tras haber comentado caso en comité de tumores torácicos, se decide tratamiento con quimio-radioterapia concomitante con cisplatino (21 sesiones de radioterapia). Posteriormente la paciente inicia seguimiento y se traslada a nuestro país. En agosto de 2014 presenta nueva progresión pleural y pararrenal izquierda, iniciando nueva línea de tratamiento según esquema Ifosfamida 1,5 mg/m2 durante 5 días, del que sólo pudo recibir un ciclo por neutropenia grado IV mantenida, requiriendo modificar esquema a TAXOL semanal (2 on y 1 off) y del que recibe 6 ciclos con estabilización de la enfermedad. Posteriormente se realiza radioterapia de consolidación sobre lesiones pleurales y pararrenal izquierda, finalizando el tratamiento en agosto 2015. En marzo de 2016 se evidencia en TC nueva recaída de la enfermedad a nivel pleural y se reinicia TAXOL semanal, recibiendo sólo 3 ciclos por presentar de nuevo toxicidad hematológica. Mantiene estabilidad de la enfermedad hasta enero de 2017, donde progresa de nuevo a nivel pleural y ganglionar. Ante el antecedente de toxicidad previa, se inicia tratamiento con pemetrexed 500 mg/m2 día 1 cada 21 días, recibiendo un total de 6 ciclos desde marzo a septiembre 2017 e iniciando de nuevo seguimiento (se decide stop de tratamiento por estabilidad de la enfermedad y toxicidad acumulada). En diciembre 2017 se evidencia progresión de la enfermedad locorregional y pleural comentándose caso en comité de tumores y decidiéndose resección parcial de la enfermedad, que se realiza en febrero 2018. La Anatomía Patológica fue de timoma tipo B2 invasor con alto índice proliferativo (Ki 67 de 40-50 %) y alta expresión de PDL1 (80 %). Tras la cirugía, la enfermedad se mantendría estable hasta septiembre de 2018, donde se objetiva nueva progresión a nivel pleuropulmonar, pararrenal y nuevos implantes intraabdominales. Se vuelve a comentar caso en sesión y ante hallazgos de Anatomía Patológica y toxicidad previa a quimioterapia, se solicita inmunoterapia con nivolumab como uso compasivo, iniciando ciclo 1 el 26 de septiembre de 2018. El día 5 de octubre consulta en el Servicio de Urgencias por cuadro de 3-4 días de evolución de astenia, debilidad muscular proximal, ptosis y diplopía. Exploración física » Consciente, orientada, afebril, eupneica en reposo. » NRL: funciones superiores conservadas. Pupilas "normocóricas" y normorreactivas, ptosis bilateral, oftalmoparesia para la aducción de ambos rectos internos en mirada lateral. » Balance motor: deltoides basal 4+/5 bilateral, tras 10 repeticiones fatiga y 4-/5 derecho y 3/5 izquierdo. Flexores de cuello basal 4/5, tras 5 repeticiones 3-/5. » Test del hielo en consulta positivo: mejoría notable de la oftalmoparesia y la ptosis. Pruebas complementarias » » Analítica con bioquímica, hemograma y coagulación rigurosamente normal. » » Se realiza TC de cráneo en el que no se objetivan hallazgos patológicos. » Se extrae analítica para estudio de perfil autoinmune (anticuerpos anti-AChR, anti-Musk y anti-músculo estriado). Diagnóstico Sospecha de miastenia gravis en paciente con timoma tras primer ciclo de nivolumab. Tratamiento » Piridostigmina 60 mg cada 8 horas. » Prednisona 60 mg cada 24 horas. Evolución Tras alta a domicilio con piridostigmina y corticoides, la paciente consulta de nuevo en Urgencias a los 5 días por el mismo cuadro, asociando, además, disnea y tos de 24-48 horas de evolución, sin fiebre. Se realiza angio-TC de tórax, la cual descarta progresión de la enfermedad, TEP, neumonía o neumonitis por toxicidad a inmunoterapia. Se traslada a sala de observación para iniciar tratamiento intravenoso con inmunoglobulinas y, ante la no mejoría del cuadro y la inestabilización de la paciente, termina ingresando en UCI. La paciente requiere intubación orotraqueal y tratamiento mediante plasmaféresis. Tras la primera semana, en la que no se había obtenido respuesta al tratamiento, se reciben los resultados de los anticuerpos solicitados: anti-AChR > 20 (0-0,45) y anti-Musk < 0,4 (0-0,4). En aquel momento se considera el diagnóstico de crisis miasténica Osserman grado 5 en relación a síndrome paraneoplásico del tumor primario, por lo que se presenta el caso en comité de tumores y se decide iniciar quimioterapia según esquema cisplatino, doxorrubicina y ciclofosfamida (CAP). Tras el primer ciclo, parece existir una ligera respuesta durante las primeras 48 horas. Sin embargo, y a pesar de un segundo ciclo de tratamiento, el cuadro continuaría progresando hasta finalmente producir la muerte de la paciente tras 38 días de ingreso en UCI. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Anamnesis Mujer de 39 años, sin antecedentes de interés. En diciembre de 2012 inicia estudio en su país de origen por cuadro de disnea de un año de evolución asociado a dolor torácico. La TC objetiva un tumor de 92 x 74 mm que ocupa el mediastino anterior y que invade pericardio, porción ascendente del cayado aórtico y tronco de la arteria pulmonar. Se realiza resección tumoral parcial en enero de 2013, obteniendo el diagnóstico anatomopatológico de timoma tipo B1 con infiltración capsular. Posteriormente, la paciente es derivada a consultas de Oncología, donde se plantea quimioterapia complementaria según esquema Descripción epirrubicina-"platamina", del que recibe 4 ciclos (último en mayo 2013). Tras progresión locorregional en septiembre 2013 y tras haber comentado caso en comité de tumores torácicos, se decide tratamiento con quimio-radioterapia concomitante con cisplatino (21 sesiones de radioterapia). Posteriormente la paciente inicia seguimiento y se traslada a nuestro país. En agosto de 2014 presenta nueva progresión pleural y pararrenal izquierda, iniciando nueva línea de tratamiento según esquema Ifosfamida 1,5 mg/m2 durante 5 días, del que sólo pudo recibir un ciclo por neutropenia grado IV mantenida, requiriendo modificar esquema a TAXOL semanal (2 on y 1 off) y del que recibe 6 ciclos con estabilización de la enfermedad. Posteriormente se realiza radioterapia de consolidación sobre lesiones pleurales y pararrenal izquierda, finalizando el tratamiento en agosto 2015. En marzo de 2016 se evidencia en TC nueva recaída de la enfermedad a nivel pleural y se reinicia TAXOL semanal, recibiendo sólo 3 ciclos por presentar de nuevo toxicidad hematológica. Mantiene estabilidad de la enfermedad hasta enero de 2017, donde progresa de nuevo a nivel pleural y ganglionar. Ante el antecedente de toxicidad previa, se inicia tratamiento con pemetrexed 500 mg/m2 día 1 cada 21 días, recibiendo un total de 6 ciclos desde marzo a septiembre 2017 e iniciando de nuevo seguimiento (se decide stop de tratamiento por estabilidad de la enfermedad y toxicidad acumulada). En diciembre 2017 se evidencia progresión de la enfermedad locorregional y pleural comentándose caso en comité de tumores y decidiéndose resección parcial de la enfermedad, que se realiza en febrero 2018. La Anatomía Patológica fue de timoma tipo B2 invasor con alto índice proliferativo (Ki 67 de 40-50 %) y alta expresión de PDL1 (80 %). Tras la cirugía, la enfermedad se mantendría estable hasta septiembre de 2018, donde se objetiva nueva progresión a nivel pleuropulmonar, pararrenal y nuevos implantes intraabdominales. Se vuelve a comentar caso en sesión y ante hallazgos de Anatomía Patológica y toxicidad previa a quimioterapia, se solicita inmunoterapia con nivolumab como uso compasivo, iniciando ciclo 1 el 26 de septiembre de 2018. El día 5 de octubre consulta en el Servicio de Urgencias por cuadro de 3-4 días de evolución de astenia, debilidad muscular proximal, ptosis y diplopía. Exploración física » Consciente, orientada, afebril, eupneica en reposo. » NRL: funciones superiores conservadas. Pupilas "normocóricas" y normorreactivas, ptosis bilateral, oftalmoparesia para la aducción de ambos rectos internos en mirada lateral. » Balance motor: deltoides basal 4+/5 bilateral, tras 10 repeticiones fatiga y 4-/5 derecho y 3/5 izquierdo. Flexores de cuello basal 4/5, tras 5 repeticiones 3-/5. » Test del hielo en consulta positivo: mejoría notable de la oftalmoparesia y la ptosis. Pruebas complementarias » » Analítica con bioquímica, hemograma y coagulación rigurosamente normal. » » Se realiza TC de cráneo en el que no se objetivan hallazgos patológicos. » Se extrae analítica para estudio de perfil autoinmune (anticuerpos anti-AChR, anti-Musk y anti-músculo estriado). Diagnóstico Sospecha de miastenia gravis en paciente con timoma tras primer ciclo de nivolumab. Tratamiento » Piridostigmina 60 mg cada 8 horas. » Prednisona 60 mg cada 24 horas. Evolución Tras alta a domicilio con piridostigmina y corticoides, la paciente consulta de nuevo en Urgencias a los 5 días por el mismo cuadro, asociando, además, disnea y tos de 24-48 horas de evolución, sin fiebre. Se realiza angio-TC de tórax, la cual descarta progresión de la enfermedad, TEP, neumonía o neumonitis por toxicidad a inmunoterapia. Se traslada a sala de observación para iniciar tratamiento intravenoso con inmunoglobulinas y, ante la no mejoría del cuadro y la inestabilización de la paciente, termina ingresando en UCI. La paciente requiere intubación orotraqueal y tratamiento mediante plasmaféresis. Tras la primera semana, en la que no se había obtenido respuesta al tratamiento, se reciben los resultados de los anticuerpos solicitados: anti-AChR > 20 (0-0,45) y anti-Musk < 0,4 (0-0,4). En aquel momento se considera el diagnóstico de crisis miasténica Osserman grado 5 en relación a síndrome paraneoplásico del tumor primario, por lo que se presenta el caso en comité de tumores y se decide iniciar quimioterapia según esquema cisplatino, doxorrubicina y ciclofosfamida (CAP). Tras el primer ciclo, parece existir una ligera respuesta durante las primeras 48 horas. Sin embargo, y a pesar de un segundo ciclo de tratamiento, el cuadro continuaría progresando hasta finalmente producir la muerte de la paciente tras 38 días de ingreso en UCI.	[ "Anamnesis", "\n", "Mujer", "de", "39", "años", ",", "sin", "antecedentes", "de", "interés", ".", "\n", "En", "diciembre", "de", "2012", "inicia", "estudio", "en", "su", "país", "de", "origen", "por", "cuadro", "de", "disnea", "de", "un", "año", "de", "evolución", "asociado", "a", "dolor", "torácico", ".", "La", "TC", "objetiva", "un", "tumor", "de", "92", "x", "74", "mm", "que", "ocupa", "el", "mediastino", "anterior", "y", "que", "invade", "pericardio", ",", "porción", "ascendente", "del", "cayado", "aórtico", "y", "tronco", "de", "la", "arteria", "pulmonar", ".", "Se", "realiza", "resección", "tumoral", "parcial", "en", "enero", "de", "2013", ",", "obteniendo", "el", "diagnóstico", "anatomopatológico", "de", "timoma", "tipo", "B1", "con", "infiltración", "capsular", ".", "\n", "Posteriormente", ",", "la", "paciente", "es", "derivada", "a", "consultas", "de", "Oncología", ",", "donde", "se", "plantea", "quimioterapia", "complementaria", "según", "esquema", "Descripción", "epirrubicina-\"platamina", "\"", ",", "del", "que", "recibe", "4", "ciclos", "(", "último", "en", "mayo", "2013", ")", ".", "\n", "Tras", "progresión", "locorregional", "en", "septiembre", "2013", "y", "tras", "haber", "comentado", "caso", "en", "comité", "de", "tumores", "torácicos", ",", "se", "decide", "tratamiento", "con", "quimio", "-", "radioterapia", "concomitante", "con", "cisplatino", "(", "21", "sesiones", "de", "radioterapia", ")", ".", "Posteriormente", "la", "paciente", "inicia", "seguimiento", "y", "se", "traslada", "a", "nuestro", "país", ".", "\n", "En", "agosto", "de", "2014", "presenta", "nueva", "progresión", "pleural", "y", "pararrenal", "izquierda", ",", "iniciando", "nueva", "línea", "de", "tratamiento", "según", "esquema", "Ifosfamida", "1,5", "mg", "/", "m2", "durante", "5", "días", ",", "del", "que", "sólo", "pudo", "recibir", "un", "ciclo", "por", "neutropenia", "grado", "IV", "mantenida", ",", "requiriendo", "modificar", "esquema", "a", "TAXOL", "semanal", "(", "2", "on", "y", "1", "off", ")", "y", "del", "que", "recibe", "6", "ciclos", "con", "estabilización", "de", "la", "enfermedad", ".", "Posteriormente", "se", "realiza", "radioterapia", "de", "consolidación", "sobre", "lesiones", "pleurales", "y", "pararrenal", "izquierda", ",", "finalizando", "el", "tratamiento", "en", "agosto", "2015", ".", "\n", "En", "marzo", "de", "2016", "se", "evidencia", "en", "TC", "nueva", "recaída", "de", "la", "enfermedad", "a", "nivel", "pleural", "y", "se", "reinicia", "TAXOL", "semanal", ",", "recibiendo", "sólo", "3", "ciclos", "por", "presentar", "de", "nuevo", "toxicidad", "hematológica", ".", "Mantiene", "estabilidad", "de", "la", "enfermedad", "hasta", "enero", "de", "2017", ",", "donde", "progresa", "de", "nuevo", "a", "nivel", "pleural", "y", "ganglionar", ".", "Ante", "el", "antecedente", "de", "toxicidad", "previa", ",", "se", "inicia", "tratamiento", "con", "pemetrexed", "500", "mg", "/", "m2", "día", "1", "cada", "21", "días", ",", "recibiendo", "un", "total", "de", "6", "ciclos", "desde", "marzo", "a", "septiembre", "2017", "e", "iniciando", "de", "nuevo", "seguimiento", "(", "se", "decide", "stop", "de", "tratamiento", "por", "estabilidad", "de", "la", "enfermedad", "y", "toxicidad", "acumulada", ")", ".", "\n", "En", "diciembre", "2017", "se", "evidencia", "progresión", "de", "la", "enfermedad", "locorregional", "y", "pleural", "comentándose", "caso", "en", "comité", "de", "tumores", "y", "decidiéndose", "resección", "parcial", "de", "la", "enfermedad", ",", "que", "se", "realiza", "en", "febrero", "2018", ".", "La", "Anatomía", "Patológica", "fue", "de", "timoma", "tipo", "B2", "invasor", "con", "alto", "índice", "proliferativo", "(", "Ki", "67", "de", "40", "-", "50", "%", ")", "y", "alta", "expresión", "de", "PDL1", "(", "80", "%", ")", ".", "\n", "Tras", "la", "cirugía", ",", "la", "enfermedad", "se", "mantendría", "estable", "hasta", "septiembre", "de", "2018", ",", "donde", "se", "objetiva", "nueva", "progresión", "a", "nivel", "pleuropulmonar", ",", "pararrenal", "y", "nuevos", "implantes", "intraabdominales", ".", "Se", "vuelve", "a", "comentar", "caso", "en", "sesión", "y", "ante", "hallazgos", "de", "Anatomía", "Patológica", "y", "toxicidad", "previa", "a", "quimioterapia", ",", "se", "solicita", "inmunoterapia", "con", "nivolumab", "como", "uso", "compasivo", ",", "iniciando", "ciclo", "1", "el", "26", "de", "septiembre", "de", "2018", ".", "\n", "El", "día", "5", "de", "octubre", "consulta", "en", "el", "Servicio", "de", "Urgencias", "por", "cuadro", "de", "3", "-", "4", "días", "de", "evolución", "de", "astenia", ",", "debilidad", "muscular", "proximal", ",", "ptosis", "y", "diplopía", ".", "\n\n", "Exploración", "física", "\n", "»", "Consciente", ",", "orientada", ",", "afebril", ",", "eupneica", "en", "reposo", ".", "\n", "»", "NRL", ":", "funciones", "superiores", "conservadas", ".", "Pupilas", "\"", "normocóricas", "\"", "y", "normorreactivas", ",", "ptosis", "bilateral", ",", "oftalmoparesia", "para", "la", "aducción", "de", "ambos", "rectos", "internos", "en", "mirada", "lateral", ".", "\n", "»", "Balance", "motor", ":", "deltoides", "basal", "4+/5", "bilateral", ",", "tras", "10", "repeticiones", "fatiga", "y", "4-/5", "derecho", "y", "3/5", "izquierdo", ".", "Flexores", "de", "cuello", "basal", "4/5", ",", "tras", "5", "repeticiones", "3-/5", ".", "\n", "»", "Test", "del", "hielo", "en", "consulta", "positivo", ":", "mejoría", "notable", "de", "la", "oftalmoparesia", "y", "la", "ptosis", ".", "\n\n", "Pruebas", "complementarias", "\n", "»", "»", "Analítica", "con", "bioquímica", ",", "hemograma", "y", "coagulación", "rigurosamente", "normal", ".", "\n", "»", "»", "Se", "realiza", "TC", "de", "cráneo", "en", "el", "que", "no", "se", "objetivan", "hallazgos", "patológicos", ".", "\n", "»", "Se", "extrae", "analítica", "para", "estudio", "de", "perfil", "autoinmune", "(", "anticuerpos", "anti", "-", "AChR", ",", "anti", "-", "Musk", "y", "anti", "-", "músculo", "estriado", ")", ".", "\n\n", "Diagnóstico", "\n", "Sospecha", "de", "miastenia", "gravis", "en", "paciente", "con", "timoma", "tras", "primer", "ciclo", "de", "nivolumab", ".", "\n\n", "Tratamiento", "\n", "»", "Piridostigmina", "60", "mg", "cada", "8", "horas", ".", "\n", "»", "Prednisona", "60", "mg", "cada", "24", "horas", ".", "\n\n", "Evolución", "\n", "Tras", "alta", "a", "domicilio", "con", "piridostigmina", "y", "corticoides", ",", "la", "paciente", "consulta", "de", "nuevo", "en", "Urgencias", "a", "los", "5", "días", "por", "el", "mismo", "cuadro", ",", "asociando", ",", "además", ",", "disnea", "y", "tos", "de", "24", "-", "48", "horas", "de", "evolución", ",", "sin", "fiebre", ".", "Se", "realiza", "angio", "-", "TC", "de", "tórax", ",", "la", "cual", "descarta", "progresión", "de", "la", "enfermedad", ",", "TEP", ",", "neumonía", "o", "neumonitis", "por", "toxicidad", "a", "inmunoterapia", ".", "Se", "traslada", "a", "sala", "de", "observación", "para", "iniciar", "tratamiento", "intravenoso", "con", "inmunoglobulinas", "y", ",", "ante", "la", "no", "mejoría", "del", "cuadro", "y", "la", "inestabilización", "de", "la", "paciente", ",", "termina", "ingresando", "en", "UCI", ".", "\n", "La", "paciente", "requiere", "intubación", "orotraqueal", "y", "tratamiento", "mediante", "plasmaféresis", ".", "Tras", "la", "primera", "semana", ",", "en", "la", "que", "no", "se", "había", "obtenido", "respuesta", "al", "tratamiento", ",", "se", "reciben", "los", "resultados", "de", "los", "anticuerpos", "solicitados", ":", "anti", "-", "AChR", ">", "20", "(", "0", "-", "0,45", ")", "y", "anti", "-", "Musk", "<", "0,4", "(", "0", "-", "0,4", ")", ".", "\n", "En", "aquel", "momento", "se", "considera", "el", "diagnóstico", "de", "crisis", "miasténica", "Osserman", "grado", "5", "en", "relación", "a", "síndrome", "paraneoplásico", "del", "tumor", "primario", ",", "por", "lo", "que", "se", "presenta", "el", "caso", "en", "comité", "de", "tumores", "y", "se", "decide", "iniciar", "quimioterapia", "según", "esquema", "cisplatino", ",", "doxorrubicina", "y", "ciclofosfamida", "(", "CAP", ")", ".", "\n", "Tras", "el", "primer", "ciclo", ",", "parece", "existir", "una", "ligera", "respuesta", "durante", "las", "primeras", "48", "horas", ".", "Sin", "embargo", ",", "y", "a", "pesar", "de", "un", "segundo", "ciclo", "de", "tratamiento", ",", "el", "cuadro", "continuaría", "progresando", "hasta", "finalmente", "producir", "la", "muerte", "de", "la", "paciente", "tras", "38", "días", "de", "ingreso", "en", "UCI", "." ]	[ "MORFOLOGIA_NEOPLASIA" ]
Epithelabloesung is an umlsterm, Frauen is an umlsterm, Mann is an umlsterm, Gebrauch is an umlsterm, Zahnpasta is an umlsterm, Samtweiss is an umlsterm, Methoden is an umlsterm, Patienten is an umlsterm, Epithels is an umlsterm, Schleimhaut is an umlsterm, Gingiva is an umlsterm, Membranen is an umlsterm, Blutungen is an umlsterm, Epithelproben is an umlsterm, Membranen is an umlsterm, Epithels is an umlsterm, Patienten is an umlsterm, Natriumlaurylsulfat is an umlsterm	MundKieferGesichtschirurgie.90030078.ger.abstr_task0	Sentence: Fragestellung : Ein ungewoehnliches klinisches Bild von Epithelabloesung bei 6 Frauen und 1 Mann nach Gebrauch einer neuen Zahnpasta Odol-med 3 Samtweiss wird beschrieben . Material und Methoden : 7 Patienten im Alter zwischen 31 und 72 Jahren litten an einer allgemeinen Abloesung des Epithels der oralen Schleimhaut . In allen Bereichen der Mundhoehle einschliesslich der Gingiva propria wurde eine leukoedemartige Schicht gefunden , die sich spontan abloeste oder in Membranen von 1 cm2 leicht mit der Pinzette abgeloest werden konnte . Es traten keine Blutungen , jedoch in 2 Faellen schmerzhafte Erosionen auf . Epithelproben wurden histologisch und mikrobiologisch , insbesondere auf Candidaspezies untersucht . Ergebnisse und Diskussion : Die abgeloesten Membranen erwiesen sich histologisch als die obersten 2-15 Zellschichten des Epithels ohne Dysplasie oder Vesikel . Eine normale Flora wurde isoliert . Alle Patienten hatten 2-4 Wochen zuvor begonnen , die neue Zahnpaste zu gebrauchen . Nach Absetzen des Praeparats verschwanden die Veraenderungen . Moegliche Ursachen der Epitheliolyse ( Natriumlaurylsulfat Natriumtripolyphosphat ) , werden diskutiert . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]	Fragestellung : Ein ungewoehnliches klinisches Bild von Epithelabloesung bei 6 Frauen und 1 Mann nach Gebrauch einer neuen Zahnpasta Odol-med 3 Samtweiss wird beschrieben . Material und Methoden : 7 Patienten im Alter zwischen 31 und 72 Jahren litten an einer allgemeinen Abloesung des Epithels der oralen Schleimhaut . In allen Bereichen der Mundhoehle einschliesslich der Gingiva propria wurde eine leukoedemartige Schicht gefunden , die sich spontan abloeste oder in Membranen von 1 cm2 leicht mit der Pinzette abgeloest werden konnte . Es traten keine Blutungen , jedoch in 2 Faellen schmerzhafte Erosionen auf . Epithelproben wurden histologisch und mikrobiologisch , insbesondere auf Candidaspezies untersucht . Ergebnisse und Diskussion : Die abgeloesten Membranen erwiesen sich histologisch als die obersten 2-15 Zellschichten des Epithels ohne Dysplasie oder Vesikel . Eine normale Flora wurde isoliert . Alle Patienten hatten 2-4 Wochen zuvor begonnen , die neue Zahnpaste zu gebrauchen . Nach Absetzen des Praeparats verschwanden die Veraenderungen . Moegliche Ursachen der Epitheliolyse ( Natriumlaurylsulfat Natriumtripolyphosphat ) , werden diskutiert .	[ "Fragestellung", ":", "Ein", "ungewoehnliches", "klinisches", "Bild", "von", "Epithelabloesung", "bei", "6", "Frauen", "und", "1", "Mann", "nach", "Gebrauch", "einer", "neuen", "Zahnpasta", "Odol", "-", "med", "3", "Samtweiss", "wird", "beschrieben", ".", "Material", "und", "Methoden", ":", "7", "Patienten", "im", "Alter", "zwischen", "31", "und", "72", "Jahren", "litten", "an", "einer", "allgemeinen", "Abloesung", "des", "Epithels", "der", "oralen", "Schleimhaut", ".", "In", "allen", "Bereichen", "der", "Mundhoehle", "einschliesslich", "der", "Gingiva", "propria", "wurde", "eine", "leukoedemartige", "Schicht", "gefunden", ",", "die", "sich", "spontan", "abloeste", "oder", "in", "Membranen", "von", "1", "cm2", "leicht", "mit", "der", "Pinzette", "abgeloest", "werden", "konnte", ".", "Es", "traten", "keine", "Blutungen", ",", "jedoch", "in", "2", "Faellen", "schmerzhafte", "Erosionen", "auf", ".", "Epithelproben", "wurden", "histologisch", "und", "mikrobiologisch", ",", "insbesondere", "auf", "Candidaspezies", "untersucht", ".", "Ergebnisse", "und", "Diskussion", ":", "Die", "abgeloesten", "Membranen", "erwiesen", "sich", "histologisch", "als", "die", "obersten", "2", "-", "15", "Zellschichten", "des", "Epithels", "ohne", "Dysplasie", "oder", "Vesikel", ".", "Eine", "normale", "Flora", "wurde", "isoliert", ".", "Alle", "Patienten", "hatten", "2", "-", "4", "Wochen", "zuvor", "begonnen", ",", "die", "neue", "Zahnpaste", "zu", "gebrauchen", ".", "Nach", "Absetzen", "des", "Praeparats", "verschwanden", "die", "Veraenderungen", ".", "Moegliche", "Ursachen", "der", "Epitheliolyse", "(", "Natriumlaurylsulfat", "Natriumtripolyphosphat", ")", ",", "werden", "diskutiert", "." ]	[ "umlsterm" ]
Epithelabloesung is an umlsterm, Frauen is an umlsterm, Mann is an umlsterm, Gebrauch is an umlsterm, Zahnpasta is an umlsterm, Samtweiss is an umlsterm, Methoden is an umlsterm, Patienten is an umlsterm, Epithels is an umlsterm, Schleimhaut is an umlsterm, Gingiva is an umlsterm, Membranen is an umlsterm, Blutungen is an umlsterm, Epithelproben is an umlsterm, Membranen is an umlsterm, Epithels is an umlsterm, Patienten is an umlsterm, Natriumlaurylsulfat is an umlsterm	MundKieferGesichtschirurgie.90030078.ger.abstr_task1	Sentence: Fragestellung : Ein ungewoehnliches klinisches Bild von Epithelabloesung bei 6 Frauen und 1 Mann nach Gebrauch einer neuen Zahnpasta Odol-med 3 Samtweiss wird beschrieben . Material und Methoden : 7 Patienten im Alter zwischen 31 und 72 Jahren litten an einer allgemeinen Abloesung des Epithels der oralen Schleimhaut . In allen Bereichen der Mundhoehle einschliesslich der Gingiva propria wurde eine leukoedemartige Schicht gefunden , die sich spontan abloeste oder in Membranen von 1 cm2 leicht mit der Pinzette abgeloest werden konnte . Es traten keine Blutungen , jedoch in 2 Faellen schmerzhafte Erosionen auf . Epithelproben wurden histologisch und mikrobiologisch , insbesondere auf Candidaspezies untersucht . Ergebnisse und Diskussion : Die abgeloesten Membranen erwiesen sich histologisch als die obersten 2-15 Zellschichten des Epithels ohne Dysplasie oder Vesikel . Eine normale Flora wurde isoliert . Alle Patienten hatten 2-4 Wochen zuvor begonnen , die neue Zahnpaste zu gebrauchen . Nach Absetzen des Praeparats verschwanden die Veraenderungen . Moegliche Ursachen der Epitheliolyse ( Natriumlaurylsulfat Natriumtripolyphosphat ) , werden diskutiert . Instructions: please typing these entity words according to sentence: Epithelabloesung, Frauen, Mann, Gebrauch, Zahnpasta, Samtweiss, Methoden, Patienten, Epithels, Schleimhaut, Gingiva, Membranen, Blutungen, Epithelproben, Membranen, Epithels, Patienten, Natriumlaurylsulfat Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]	Fragestellung : Ein ungewoehnliches klinisches Bild von Epithelabloesung bei 6 Frauen und 1 Mann nach Gebrauch einer neuen Zahnpasta Odol-med 3 Samtweiss wird beschrieben . Material und Methoden : 7 Patienten im Alter zwischen 31 und 72 Jahren litten an einer allgemeinen Abloesung des Epithels der oralen Schleimhaut . In allen Bereichen der Mundhoehle einschliesslich der Gingiva propria wurde eine leukoedemartige Schicht gefunden , die sich spontan abloeste oder in Membranen von 1 cm2 leicht mit der Pinzette abgeloest werden konnte . Es traten keine Blutungen , jedoch in 2 Faellen schmerzhafte Erosionen auf . Epithelproben wurden histologisch und mikrobiologisch , insbesondere auf Candidaspezies untersucht . Ergebnisse und Diskussion : Die abgeloesten Membranen erwiesen sich histologisch als die obersten 2-15 Zellschichten des Epithels ohne Dysplasie oder Vesikel . Eine normale Flora wurde isoliert . Alle Patienten hatten 2-4 Wochen zuvor begonnen , die neue Zahnpaste zu gebrauchen . Nach Absetzen des Praeparats verschwanden die Veraenderungen . Moegliche Ursachen der Epitheliolyse ( Natriumlaurylsulfat Natriumtripolyphosphat ) , werden diskutiert .	[ "Fragestellung", ":", "Ein", "ungewoehnliches", "klinisches", "Bild", "von", "Epithelabloesung", "bei", "6", "Frauen", "und", "1", "Mann", "nach", "Gebrauch", "einer", "neuen", "Zahnpasta", "Odol", "-", "med", "3", "Samtweiss", "wird", "beschrieben", ".", "Material", "und", "Methoden", ":", "7", "Patienten", "im", "Alter", "zwischen", "31", "und", "72", "Jahren", "litten", "an", "einer", "allgemeinen", "Abloesung", "des", "Epithels", "der", "oralen", "Schleimhaut", ".", "In", "allen", "Bereichen", "der", "Mundhoehle", "einschliesslich", "der", "Gingiva", "propria", "wurde", "eine", "leukoedemartige", "Schicht", "gefunden", ",", "die", "sich", "spontan", "abloeste", "oder", "in", "Membranen", "von", "1", "cm2", "leicht", "mit", "der", "Pinzette", "abgeloest", "werden", "konnte", ".", "Es", "traten", "keine", "Blutungen", ",", "jedoch", "in", "2", "Faellen", "schmerzhafte", "Erosionen", "auf", ".", "Epithelproben", "wurden", "histologisch", "und", "mikrobiologisch", ",", "insbesondere", "auf", "Candidaspezies", "untersucht", ".", "Ergebnisse", "und", "Diskussion", ":", "Die", "abgeloesten", "Membranen", "erwiesen", "sich", "histologisch", "als", "die", "obersten", "2", "-", "15", "Zellschichten", "des", "Epithels", "ohne", "Dysplasie", "oder", "Vesikel", ".", "Eine", "normale", "Flora", "wurde", "isoliert", ".", "Alle", "Patienten", "hatten", "2", "-", "4", "Wochen", "zuvor", "begonnen", ",", "die", "neue", "Zahnpaste", "zu", "gebrauchen", ".", "Nach", "Absetzen", "des", "Praeparats", "verschwanden", "die", "Veraenderungen", ".", "Moegliche", "Ursachen", "der", "Epitheliolyse", "(", "Natriumlaurylsulfat", "Natriumtripolyphosphat", ")", ",", "werden", "diskutiert", "." ]	[ "umlsterm" ]
Epithelabloesung, Frauen, Mann, Gebrauch, Zahnpasta, Samtweiss, Methoden, Patienten, Epithels, Schleimhaut, Gingiva, Membranen, Blutungen, Epithelproben, Membranen, Epithels, Patienten, Natriumlaurylsulfat	MundKieferGesichtschirurgie.90030078.ger.abstr_task2	Sentence: Fragestellung : Ein ungewoehnliches klinisches Bild von Epithelabloesung bei 6 Frauen und 1 Mann nach Gebrauch einer neuen Zahnpasta Odol-med 3 Samtweiss wird beschrieben . Material und Methoden : 7 Patienten im Alter zwischen 31 und 72 Jahren litten an einer allgemeinen Abloesung des Epithels der oralen Schleimhaut . In allen Bereichen der Mundhoehle einschliesslich der Gingiva propria wurde eine leukoedemartige Schicht gefunden , die sich spontan abloeste oder in Membranen von 1 cm2 leicht mit der Pinzette abgeloest werden konnte . Es traten keine Blutungen , jedoch in 2 Faellen schmerzhafte Erosionen auf . Epithelproben wurden histologisch und mikrobiologisch , insbesondere auf Candidaspezies untersucht . Ergebnisse und Diskussion : Die abgeloesten Membranen erwiesen sich histologisch als die obersten 2-15 Zellschichten des Epithels ohne Dysplasie oder Vesikel . Eine normale Flora wurde isoliert . Alle Patienten hatten 2-4 Wochen zuvor begonnen , die neue Zahnpaste zu gebrauchen . Nach Absetzen des Praeparats verschwanden die Veraenderungen . Moegliche Ursachen der Epitheliolyse ( Natriumlaurylsulfat Natriumtripolyphosphat ) , werden diskutiert . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]	Fragestellung : Ein ungewoehnliches klinisches Bild von Epithelabloesung bei 6 Frauen und 1 Mann nach Gebrauch einer neuen Zahnpasta Odol-med 3 Samtweiss wird beschrieben . Material und Methoden : 7 Patienten im Alter zwischen 31 und 72 Jahren litten an einer allgemeinen Abloesung des Epithels der oralen Schleimhaut . In allen Bereichen der Mundhoehle einschliesslich der Gingiva propria wurde eine leukoedemartige Schicht gefunden , die sich spontan abloeste oder in Membranen von 1 cm2 leicht mit der Pinzette abgeloest werden konnte . Es traten keine Blutungen , jedoch in 2 Faellen schmerzhafte Erosionen auf . Epithelproben wurden histologisch und mikrobiologisch , insbesondere auf Candidaspezies untersucht . Ergebnisse und Diskussion : Die abgeloesten Membranen erwiesen sich histologisch als die obersten 2-15 Zellschichten des Epithels ohne Dysplasie oder Vesikel . Eine normale Flora wurde isoliert . Alle Patienten hatten 2-4 Wochen zuvor begonnen , die neue Zahnpaste zu gebrauchen . Nach Absetzen des Praeparats verschwanden die Veraenderungen . Moegliche Ursachen der Epitheliolyse ( Natriumlaurylsulfat Natriumtripolyphosphat ) , werden diskutiert .	[ "Fragestellung", ":", "Ein", "ungewoehnliches", "klinisches", "Bild", "von", "Epithelabloesung", "bei", "6", "Frauen", "und", "1", "Mann", "nach", "Gebrauch", "einer", "neuen", "Zahnpasta", "Odol", "-", "med", "3", "Samtweiss", "wird", "beschrieben", ".", "Material", "und", "Methoden", ":", "7", "Patienten", "im", "Alter", "zwischen", "31", "und", "72", "Jahren", "litten", "an", "einer", "allgemeinen", "Abloesung", "des", "Epithels", "der", "oralen", "Schleimhaut", ".", "In", "allen", "Bereichen", "der", "Mundhoehle", "einschliesslich", "der", "Gingiva", "propria", "wurde", "eine", "leukoedemartige", "Schicht", "gefunden", ",", "die", "sich", "spontan", "abloeste", "oder", "in", "Membranen", "von", "1", "cm2", "leicht", "mit", "der", "Pinzette", "abgeloest", "werden", "konnte", ".", "Es", "traten", "keine", "Blutungen", ",", "jedoch", "in", "2", "Faellen", "schmerzhafte", "Erosionen", "auf", ".", "Epithelproben", "wurden", "histologisch", "und", "mikrobiologisch", ",", "insbesondere", "auf", "Candidaspezies", "untersucht", ".", "Ergebnisse", "und", "Diskussion", ":", "Die", "abgeloesten", "Membranen", "erwiesen", "sich", "histologisch", "als", "die", "obersten", "2", "-", "15", "Zellschichten", "des", "Epithels", "ohne", "Dysplasie", "oder", "Vesikel", ".", "Eine", "normale", "Flora", "wurde", "isoliert", ".", "Alle", "Patienten", "hatten", "2", "-", "4", "Wochen", "zuvor", "begonnen", ",", "die", "neue", "Zahnpaste", "zu", "gebrauchen", ".", "Nach", "Absetzen", "des", "Praeparats", "verschwanden", "die", "Veraenderungen", ".", "Moegliche", "Ursachen", "der", "Epitheliolyse", "(", "Natriumlaurylsulfat", "Natriumtripolyphosphat", ")", ",", "werden", "diskutiert", "." ]	[ "umlsterm" ]
p27KIP1 is a protein, D - type cyclins is a protein-family, CDK4 is a protein, cyclin E is a protein-family, CDK2 is a protein, p27KIP1 is a protein, cyclin D - CDK4 is a protein-complex, cyclin E - CDK2 is a protein-complex	1.0alpha7.train.157_task0	Sentence: Second, it is now believed that p27KIP1 interacts mostly with D-type cyclins and CDK4 and more weakly with cyclin E and CDK2, and that binding of p27KIP1 to cyclin D-CDK4 would allow the activation of cyclin E-CDK2 complexes at the G1-S transition (54, 55, 56). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: protein-family, protein, protein-complex	[ "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "B-protein-family", "I-protein-family", "I-protein-family", "I-protein-family", "O", "B-protein", "O", "O", "O", "O", "B-protein-family", "I-protein-family", "O", "B-protein", "O", "O", "O", "O", "O", "B-protein", "O", "B-protein-complex", "I-protein-complex", "I-protein-complex", "I-protein-complex", "O", "O", "O", "O", "O", "B-protein-complex", "I-protein-complex", "I-protein-complex", "I-protein-complex", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Second, it is now believed that p27KIP1 interacts mostly with D-type cyclins and CDK4 and more weakly with cyclin E and CDK2, and that binding of p27KIP1 to cyclin D-CDK4 would allow the activation of cyclin E-CDK2 complexes at the G1-S transition (54, 55, 56).	[ "Second", ",", "it", "is", "now", "believed", "that", "p27KIP1", "interacts", "mostly", "with", "D", "-", "type", "cyclins", "and", "CDK4", "and", "more", "weakly", "with", "cyclin", "E", "and", "CDK2", ",", "and", "that", "binding", "of", "p27KIP1", "to", "cyclin", "D", "-", "CDK4", "would", "allow", "the", "activation", "of", "cyclin", "E", "-", "CDK2", "complexes", "at", "the", "G1-S", "transition", "(", "54", ",", "55", ",", "56", ")", "." ]	[ "protein-family", "protein-complex", "protein" ]
p27KIP1 is a protein, D - type cyclins is a protein-family, CDK4 is a protein, cyclin E is a protein-family, CDK2 is a protein, p27KIP1 is a protein, cyclin D - CDK4 is a protein-complex, cyclin E - CDK2 is a protein-complex	1.0alpha7.train.157_task1	Sentence: Second, it is now believed that p27KIP1 interacts mostly with D-type cyclins and CDK4 and more weakly with cyclin E and CDK2, and that binding of p27KIP1 to cyclin D-CDK4 would allow the activation of cyclin E-CDK2 complexes at the G1-S transition (54, 55, 56). Instructions: please typing these entity words according to sentence: p27KIP1, D - type cyclins, CDK4, cyclin E, CDK2, p27KIP1, cyclin D - CDK4, cyclin E - CDK2 Options: protein-family, protein, protein-complex	[ "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "B-protein-family", "I-protein-family", "I-protein-family", "I-protein-family", "O", "B-protein", "O", "O", "O", "O", "B-protein-family", "I-protein-family", "O", "B-protein", "O", "O", "O", "O", "O", "B-protein", "O", "B-protein-complex", "I-protein-complex", "I-protein-complex", "I-protein-complex", "O", "O", "O", "O", "O", "B-protein-complex", "I-protein-complex", "I-protein-complex", "I-protein-complex", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Second, it is now believed that p27KIP1 interacts mostly with D-type cyclins and CDK4 and more weakly with cyclin E and CDK2, and that binding of p27KIP1 to cyclin D-CDK4 would allow the activation of cyclin E-CDK2 complexes at the G1-S transition (54, 55, 56).	[ "Second", ",", "it", "is", "now", "believed", "that", "p27KIP1", "interacts", "mostly", "with", "D", "-", "type", "cyclins", "and", "CDK4", "and", "more", "weakly", "with", "cyclin", "E", "and", "CDK2", ",", "and", "that", "binding", "of", "p27KIP1", "to", "cyclin", "D", "-", "CDK4", "would", "allow", "the", "activation", "of", "cyclin", "E", "-", "CDK2", "complexes", "at", "the", "G1-S", "transition", "(", "54", ",", "55", ",", "56", ")", "." ]	[ "protein-family", "protein-complex", "protein" ]
p27KIP1, D - type cyclins, CDK4, cyclin E, CDK2, p27KIP1, cyclin D - CDK4, cyclin E - CDK2	1.0alpha7.train.157_task2	Sentence: Second, it is now believed that p27KIP1 interacts mostly with D-type cyclins and CDK4 and more weakly with cyclin E and CDK2, and that binding of p27KIP1 to cyclin D-CDK4 would allow the activation of cyclin E-CDK2 complexes at the G1-S transition (54, 55, 56). Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "B-protein-family", "I-protein-family", "I-protein-family", "I-protein-family", "O", "B-protein", "O", "O", "O", "O", "B-protein-family", "I-protein-family", "O", "B-protein", "O", "O", "O", "O", "O", "B-protein", "O", "B-protein-complex", "I-protein-complex", "I-protein-complex", "I-protein-complex", "O", "O", "O", "O", "O", "B-protein-complex", "I-protein-complex", "I-protein-complex", "I-protein-complex", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Second, it is now believed that p27KIP1 interacts mostly with D-type cyclins and CDK4 and more weakly with cyclin E and CDK2, and that binding of p27KIP1 to cyclin D-CDK4 would allow the activation of cyclin E-CDK2 complexes at the G1-S transition (54, 55, 56).	[ "Second", ",", "it", "is", "now", "believed", "that", "p27KIP1", "interacts", "mostly", "with", "D", "-", "type", "cyclins", "and", "CDK4", "and", "more", "weakly", "with", "cyclin", "E", "and", "CDK2", ",", "and", "that", "binding", "of", "p27KIP1", "to", "cyclin", "D", "-", "CDK4", "would", "allow", "the", "activation", "of", "cyclin", "E", "-", "CDK2", "complexes", "at", "the", "G1-S", "transition", "(", "54", ",", "55", ",", "56", ")", "." ]	[ "protein-family", "protein-complex", "protein" ]
Gelenke is an umlsterm, Nervenfasern is an umlsterm, Nozizeptoren is an umlsterm, gewebeschaedigender is an umlsterm, Noxen is an umlsterm, Erregung is an umlsterm, Nozizeptoren is an umlsterm, Menschen is an umlsterm, Schmerzen is an umlsterm, Nozizeptoren is an umlsterm, Gewebe is an umlsterm, Nozizeptoren is an umlsterm, Schmerzen is an umlsterm, Nozizeptoren is an umlsterm, Entzuendungsmediatoren is an umlsterm, Bradykinin is an umlsterm, Prostaglandine is an umlsterm, Nozizeptoren is an umlsterm, Substanz P is an umlsterm, Gewebe is an umlsterm, neurogene Entzuendung is an umlsterm, Nozizeptoren is an umlsterm, Gewebeveraenderungen is an umlsterm	ManuelleMedizin.70350077.ger.abstr_task0	Sentence: Gelenke werden von nozizeptiven Nervenfasern ( Nozizeptoren ) innerviert , die ausschliesslich bei Einwirkung gewebeschaedigender Reize ( Noxen ) aktiviert werden . In der Regel fuehrt die Erregung von Nozizeptoren beim wachen Menschen zu Schmerzen . Besonders bei entzuendlichen Vorgaengen werden die sensorischen Endigungen vieler Nozizeptoren im Gewebe sensibilisiert . Unter diesen Bedingungen genuegen bereits normalerweise nichtnoxische bzw. nichtschmerzhafte Reize , um die Nozizeptoren zu aktivieren und Schmerzen auszuloesen . Fuer die Sensibilisierung von Nozizeptoren ist die Wirkung von Entzuendungsmediatoren wie Bradykinin und Prostaglandine wichtig . Neben ihrer sensorischen Funktion besitzen viele Nozizeptoren auch eine efferente Funktion . Durch die Freisetzung von Neuropeptiden wie Substanz P und Calcitonin-gene-related-Peptide im Gewebe bewirken sie eine neurogene Entzuendung . Diese efferente Wirkung der Nozizeptoren traegt zur Entstehung entzuendlicher Gewebeveraenderungen bei . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Gelenke werden von nozizeptiven Nervenfasern ( Nozizeptoren ) innerviert , die ausschliesslich bei Einwirkung gewebeschaedigender Reize ( Noxen ) aktiviert werden . In der Regel fuehrt die Erregung von Nozizeptoren beim wachen Menschen zu Schmerzen . Besonders bei entzuendlichen Vorgaengen werden die sensorischen Endigungen vieler Nozizeptoren im Gewebe sensibilisiert . Unter diesen Bedingungen genuegen bereits normalerweise nichtnoxische bzw. nichtschmerzhafte Reize , um die Nozizeptoren zu aktivieren und Schmerzen auszuloesen . Fuer die Sensibilisierung von Nozizeptoren ist die Wirkung von Entzuendungsmediatoren wie Bradykinin und Prostaglandine wichtig . Neben ihrer sensorischen Funktion besitzen viele Nozizeptoren auch eine efferente Funktion . Durch die Freisetzung von Neuropeptiden wie Substanz P und Calcitonin-gene-related-Peptide im Gewebe bewirken sie eine neurogene Entzuendung . Diese efferente Wirkung der Nozizeptoren traegt zur Entstehung entzuendlicher Gewebeveraenderungen bei .	[ "Gelenke", "werden", "von", "nozizeptiven", "Nervenfasern", "(", "Nozizeptoren", ")", "innerviert", ",", "die", "ausschliesslich", "bei", "Einwirkung", "gewebeschaedigender", "Reize", "(", "Noxen", ")", "aktiviert", "werden", ".", "In", "der", "Regel", "fuehrt", "die", "Erregung", "von", "Nozizeptoren", "beim", "wachen", "Menschen", "zu", "Schmerzen", ".", "Besonders", "bei", "entzuendlichen", "Vorgaengen", "werden", "die", "sensorischen", "Endigungen", "vieler", "Nozizeptoren", "im", "Gewebe", "sensibilisiert", ".", "Unter", "diesen", "Bedingungen", "genuegen", "bereits", "normalerweise", "nichtnoxische", "bzw", ".", "nichtschmerzhafte", "Reize", ",", "um", "die", "Nozizeptoren", "zu", "aktivieren", "und", "Schmerzen", "auszuloesen", ".", "Fuer", "die", "Sensibilisierung", "von", "Nozizeptoren", "ist", "die", "Wirkung", "von", "Entzuendungsmediatoren", "wie", "Bradykinin", "und", "Prostaglandine", "wichtig", ".", "Neben", "ihrer", "sensorischen", "Funktion", "besitzen", "viele", "Nozizeptoren", "auch", "eine", "efferente", "Funktion", ".", "Durch", "die", "Freisetzung", "von", "Neuropeptiden", "wie", "Substanz", "P", "und", "Calcitonin", "-", "gene", "-", "related", "-", "Peptide", "im", "Gewebe", "bewirken", "sie", "eine", "neurogene", "Entzuendung", ".", "Diese", "efferente", "Wirkung", "der", "Nozizeptoren", "traegt", "zur", "Entstehung", "entzuendlicher", "Gewebeveraenderungen", "bei", "." ]	[ "umlsterm" ]
Gelenke is an umlsterm, Nervenfasern is an umlsterm, Nozizeptoren is an umlsterm, gewebeschaedigender is an umlsterm, Noxen is an umlsterm, Erregung is an umlsterm, Nozizeptoren is an umlsterm, Menschen is an umlsterm, Schmerzen is an umlsterm, Nozizeptoren is an umlsterm, Gewebe is an umlsterm, Nozizeptoren is an umlsterm, Schmerzen is an umlsterm, Nozizeptoren is an umlsterm, Entzuendungsmediatoren is an umlsterm, Bradykinin is an umlsterm, Prostaglandine is an umlsterm, Nozizeptoren is an umlsterm, Substanz P is an umlsterm, Gewebe is an umlsterm, neurogene Entzuendung is an umlsterm, Nozizeptoren is an umlsterm, Gewebeveraenderungen is an umlsterm	ManuelleMedizin.70350077.ger.abstr_task1	Sentence: Gelenke werden von nozizeptiven Nervenfasern ( Nozizeptoren ) innerviert , die ausschliesslich bei Einwirkung gewebeschaedigender Reize ( Noxen ) aktiviert werden . In der Regel fuehrt die Erregung von Nozizeptoren beim wachen Menschen zu Schmerzen . Besonders bei entzuendlichen Vorgaengen werden die sensorischen Endigungen vieler Nozizeptoren im Gewebe sensibilisiert . Unter diesen Bedingungen genuegen bereits normalerweise nichtnoxische bzw. nichtschmerzhafte Reize , um die Nozizeptoren zu aktivieren und Schmerzen auszuloesen . Fuer die Sensibilisierung von Nozizeptoren ist die Wirkung von Entzuendungsmediatoren wie Bradykinin und Prostaglandine wichtig . Neben ihrer sensorischen Funktion besitzen viele Nozizeptoren auch eine efferente Funktion . Durch die Freisetzung von Neuropeptiden wie Substanz P und Calcitonin-gene-related-Peptide im Gewebe bewirken sie eine neurogene Entzuendung . Diese efferente Wirkung der Nozizeptoren traegt zur Entstehung entzuendlicher Gewebeveraenderungen bei . Instructions: please typing these entity words according to sentence: Gelenke, Nervenfasern, Nozizeptoren, gewebeschaedigender, Noxen, Erregung, Nozizeptoren, Menschen, Schmerzen, Nozizeptoren, Gewebe, Nozizeptoren, Schmerzen, Nozizeptoren, Entzuendungsmediatoren, Bradykinin, Prostaglandine, Nozizeptoren, Substanz P, Gewebe, neurogene Entzuendung, Nozizeptoren, Gewebeveraenderungen Options: umlsterm	[ "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Gelenke werden von nozizeptiven Nervenfasern ( Nozizeptoren ) innerviert , die ausschliesslich bei Einwirkung gewebeschaedigender Reize ( Noxen ) aktiviert werden . In der Regel fuehrt die Erregung von Nozizeptoren beim wachen Menschen zu Schmerzen . Besonders bei entzuendlichen Vorgaengen werden die sensorischen Endigungen vieler Nozizeptoren im Gewebe sensibilisiert . Unter diesen Bedingungen genuegen bereits normalerweise nichtnoxische bzw. nichtschmerzhafte Reize , um die Nozizeptoren zu aktivieren und Schmerzen auszuloesen . Fuer die Sensibilisierung von Nozizeptoren ist die Wirkung von Entzuendungsmediatoren wie Bradykinin und Prostaglandine wichtig . Neben ihrer sensorischen Funktion besitzen viele Nozizeptoren auch eine efferente Funktion . Durch die Freisetzung von Neuropeptiden wie Substanz P und Calcitonin-gene-related-Peptide im Gewebe bewirken sie eine neurogene Entzuendung . Diese efferente Wirkung der Nozizeptoren traegt zur Entstehung entzuendlicher Gewebeveraenderungen bei .	[ "Gelenke", "werden", "von", "nozizeptiven", "Nervenfasern", "(", "Nozizeptoren", ")", "innerviert", ",", "die", "ausschliesslich", "bei", "Einwirkung", "gewebeschaedigender", "Reize", "(", "Noxen", ")", "aktiviert", "werden", ".", "In", "der", "Regel", "fuehrt", "die", "Erregung", "von", "Nozizeptoren", "beim", "wachen", "Menschen", "zu", "Schmerzen", ".", "Besonders", "bei", "entzuendlichen", "Vorgaengen", "werden", "die", "sensorischen", "Endigungen", "vieler", "Nozizeptoren", "im", "Gewebe", "sensibilisiert", ".", "Unter", "diesen", "Bedingungen", "genuegen", "bereits", "normalerweise", "nichtnoxische", "bzw", ".", "nichtschmerzhafte", "Reize", ",", "um", "die", "Nozizeptoren", "zu", "aktivieren", "und", "Schmerzen", "auszuloesen", ".", "Fuer", "die", "Sensibilisierung", "von", "Nozizeptoren", "ist", "die", "Wirkung", "von", "Entzuendungsmediatoren", "wie", "Bradykinin", "und", "Prostaglandine", "wichtig", ".", "Neben", "ihrer", "sensorischen", "Funktion", "besitzen", "viele", "Nozizeptoren", "auch", "eine", "efferente", "Funktion", ".", "Durch", "die", "Freisetzung", "von", "Neuropeptiden", "wie", "Substanz", "P", "und", "Calcitonin", "-", "gene", "-", "related", "-", "Peptide", "im", "Gewebe", "bewirken", "sie", "eine", "neurogene", "Entzuendung", ".", "Diese", "efferente", "Wirkung", "der", "Nozizeptoren", "traegt", "zur", "Entstehung", "entzuendlicher", "Gewebeveraenderungen", "bei", "." ]	[ "umlsterm" ]
Gelenke, Nervenfasern, Nozizeptoren, gewebeschaedigender, Noxen, Erregung, Nozizeptoren, Menschen, Schmerzen, Nozizeptoren, Gewebe, Nozizeptoren, Schmerzen, Nozizeptoren, Entzuendungsmediatoren, Bradykinin, Prostaglandine, Nozizeptoren, Substanz P, Gewebe, neurogene Entzuendung, Nozizeptoren, Gewebeveraenderungen	ManuelleMedizin.70350077.ger.abstr_task2	Sentence: Gelenke werden von nozizeptiven Nervenfasern ( Nozizeptoren ) innerviert , die ausschliesslich bei Einwirkung gewebeschaedigender Reize ( Noxen ) aktiviert werden . In der Regel fuehrt die Erregung von Nozizeptoren beim wachen Menschen zu Schmerzen . Besonders bei entzuendlichen Vorgaengen werden die sensorischen Endigungen vieler Nozizeptoren im Gewebe sensibilisiert . Unter diesen Bedingungen genuegen bereits normalerweise nichtnoxische bzw. nichtschmerzhafte Reize , um die Nozizeptoren zu aktivieren und Schmerzen auszuloesen . Fuer die Sensibilisierung von Nozizeptoren ist die Wirkung von Entzuendungsmediatoren wie Bradykinin und Prostaglandine wichtig . Neben ihrer sensorischen Funktion besitzen viele Nozizeptoren auch eine efferente Funktion . Durch die Freisetzung von Neuropeptiden wie Substanz P und Calcitonin-gene-related-Peptide im Gewebe bewirken sie eine neurogene Entzuendung . Diese efferente Wirkung der Nozizeptoren traegt zur Entstehung entzuendlicher Gewebeveraenderungen bei . Instructions: please extract entity words from the input sentence	[ "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Gelenke werden von nozizeptiven Nervenfasern ( Nozizeptoren ) innerviert , die ausschliesslich bei Einwirkung gewebeschaedigender Reize ( Noxen ) aktiviert werden . In der Regel fuehrt die Erregung von Nozizeptoren beim wachen Menschen zu Schmerzen . Besonders bei entzuendlichen Vorgaengen werden die sensorischen Endigungen vieler Nozizeptoren im Gewebe sensibilisiert . Unter diesen Bedingungen genuegen bereits normalerweise nichtnoxische bzw. nichtschmerzhafte Reize , um die Nozizeptoren zu aktivieren und Schmerzen auszuloesen . Fuer die Sensibilisierung von Nozizeptoren ist die Wirkung von Entzuendungsmediatoren wie Bradykinin und Prostaglandine wichtig . Neben ihrer sensorischen Funktion besitzen viele Nozizeptoren auch eine efferente Funktion . Durch die Freisetzung von Neuropeptiden wie Substanz P und Calcitonin-gene-related-Peptide im Gewebe bewirken sie eine neurogene Entzuendung . Diese efferente Wirkung der Nozizeptoren traegt zur Entstehung entzuendlicher Gewebeveraenderungen bei .	[ "Gelenke", "werden", "von", "nozizeptiven", "Nervenfasern", "(", "Nozizeptoren", ")", "innerviert", ",", "die", "ausschliesslich", "bei", "Einwirkung", "gewebeschaedigender", "Reize", "(", "Noxen", ")", "aktiviert", "werden", ".", "In", "der", "Regel", "fuehrt", "die", "Erregung", "von", "Nozizeptoren", "beim", "wachen", "Menschen", "zu", "Schmerzen", ".", "Besonders", "bei", "entzuendlichen", "Vorgaengen", "werden", "die", "sensorischen", "Endigungen", "vieler", "Nozizeptoren", "im", "Gewebe", "sensibilisiert", ".", "Unter", "diesen", "Bedingungen", "genuegen", "bereits", "normalerweise", "nichtnoxische", "bzw", ".", "nichtschmerzhafte", "Reize", ",", "um", "die", "Nozizeptoren", "zu", "aktivieren", "und", "Schmerzen", "auszuloesen", ".", "Fuer", "die", "Sensibilisierung", "von", "Nozizeptoren", "ist", "die", "Wirkung", "von", "Entzuendungsmediatoren", "wie", "Bradykinin", "und", "Prostaglandine", "wichtig", ".", "Neben", "ihrer", "sensorischen", "Funktion", "besitzen", "viele", "Nozizeptoren", "auch", "eine", "efferente", "Funktion", ".", "Durch", "die", "Freisetzung", "von", "Neuropeptiden", "wie", "Substanz", "P", "und", "Calcitonin", "-", "gene", "-", "related", "-", "Peptide", "im", "Gewebe", "bewirken", "sie", "eine", "neurogene", "Entzuendung", ".", "Diese", "efferente", "Wirkung", "der", "Nozizeptoren", "traegt", "zur", "Entstehung", "entzuendlicher", "Gewebeveraenderungen", "bei", "." ]	[ "umlsterm" ]
implantation is an umlsterm, inguinal hernia is an umlsterm, surgery is an umlsterm, man is an umlsterm, syndrome is an umlsterm, pain is an umlsterm, TAPP is an umlsterm, procedure is an umlsterm, inguinal hernia is an umlsterm, reoperation is an umlsterm, removement is an umlsterm, clips is an umlsterm, nerve is an umlsterm, operation is an umlsterm, Prolene is an umlsterm, inguinal hernia is an umlsterm, surgery is an umlsterm	DerChirurg.70681297.eng.abstr_task0	Sentence: The implantation of a mesh is an essential step in laparoscopic inguinal hernia surgery . We present the case of a 22-year-old man who developed an unspecific and refractory syndrome of inguinal pain after a TAPP procedure for a primary inguinal hernia . Repeated reoperation for removement of clips and nerve transection were unsuccessful . By a transinguinal approach , 18 months after the first operation we removed a preperitoneal Prolene mesh which had shrunk and folded to 30 % of its original size . The problem of biocompatibility of meshes currently used in inguinal hernia surgery is discussed . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O" ]	The implantation of a mesh is an essential step in laparoscopic inguinal hernia surgery . We present the case of a 22-year-old man who developed an unspecific and refractory syndrome of inguinal pain after a TAPP procedure for a primary inguinal hernia . Repeated reoperation for removement of clips and nerve transection were unsuccessful . By a transinguinal approach , 18 months after the first operation we removed a preperitoneal Prolene mesh which had shrunk and folded to 30 % of its original size . The problem of biocompatibility of meshes currently used in inguinal hernia surgery is discussed .	[ "The", "implantation", "of", "a", "mesh", "is", "an", "essential", "step", "in", "laparoscopic", "inguinal", "hernia", "surgery", ".", "We", "present", "the", "case", "of", "a", "22-year", "-", "old", "man", "who", "developed", "an", "unspecific", "and", "refractory", "syndrome", "of", "inguinal", "pain", "after", "a", "TAPP", "procedure", "for", "a", "primary", "inguinal", "hernia", ".", "Repeated", "reoperation", "for", "removement", "of", "clips", "and", "nerve", "transection", "were", "unsuccessful", ".", "By", "a", "transinguinal", "approach", ",", "18", "months", "after", "the", "first", "operation", "we", "removed", "a", "preperitoneal", "Prolene", "mesh", "which", "had", "shrunk", "and", "folded", "to", "30", "%", "of", "its", "original", "size", ".", "The", "problem", "of", "biocompatibility", "of", "meshes", "currently", "used", "in", "inguinal", "hernia", "surgery", "is", "discussed", "." ]	[ "umlsterm" ]
implantation is an umlsterm, inguinal hernia is an umlsterm, surgery is an umlsterm, man is an umlsterm, syndrome is an umlsterm, pain is an umlsterm, TAPP is an umlsterm, procedure is an umlsterm, inguinal hernia is an umlsterm, reoperation is an umlsterm, removement is an umlsterm, clips is an umlsterm, nerve is an umlsterm, operation is an umlsterm, Prolene is an umlsterm, inguinal hernia is an umlsterm, surgery is an umlsterm	DerChirurg.70681297.eng.abstr_task1	Sentence: The implantation of a mesh is an essential step in laparoscopic inguinal hernia surgery . We present the case of a 22-year-old man who developed an unspecific and refractory syndrome of inguinal pain after a TAPP procedure for a primary inguinal hernia . Repeated reoperation for removement of clips and nerve transection were unsuccessful . By a transinguinal approach , 18 months after the first operation we removed a preperitoneal Prolene mesh which had shrunk and folded to 30 % of its original size . The problem of biocompatibility of meshes currently used in inguinal hernia surgery is discussed . Instructions: please typing these entity words according to sentence: implantation, inguinal hernia, surgery, man, syndrome, pain, TAPP, procedure, inguinal hernia, reoperation, removement, clips, nerve, operation, Prolene, inguinal hernia, surgery Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O" ]	The implantation of a mesh is an essential step in laparoscopic inguinal hernia surgery . We present the case of a 22-year-old man who developed an unspecific and refractory syndrome of inguinal pain after a TAPP procedure for a primary inguinal hernia . Repeated reoperation for removement of clips and nerve transection were unsuccessful . By a transinguinal approach , 18 months after the first operation we removed a preperitoneal Prolene mesh which had shrunk and folded to 30 % of its original size . The problem of biocompatibility of meshes currently used in inguinal hernia surgery is discussed .	[ "The", "implantation", "of", "a", "mesh", "is", "an", "essential", "step", "in", "laparoscopic", "inguinal", "hernia", "surgery", ".", "We", "present", "the", "case", "of", "a", "22-year", "-", "old", "man", "who", "developed", "an", "unspecific", "and", "refractory", "syndrome", "of", "inguinal", "pain", "after", "a", "TAPP", "procedure", "for", "a", "primary", "inguinal", "hernia", ".", "Repeated", "reoperation", "for", "removement", "of", "clips", "and", "nerve", "transection", "were", "unsuccessful", ".", "By", "a", "transinguinal", "approach", ",", "18", "months", "after", "the", "first", "operation", "we", "removed", "a", "preperitoneal", "Prolene", "mesh", "which", "had", "shrunk", "and", "folded", "to", "30", "%", "of", "its", "original", "size", ".", "The", "problem", "of", "biocompatibility", "of", "meshes", "currently", "used", "in", "inguinal", "hernia", "surgery", "is", "discussed", "." ]	[ "umlsterm" ]
implantation, inguinal hernia, surgery, man, syndrome, pain, TAPP, procedure, inguinal hernia, reoperation, removement, clips, nerve, operation, Prolene, inguinal hernia, surgery	DerChirurg.70681297.eng.abstr_task2	Sentence: The implantation of a mesh is an essential step in laparoscopic inguinal hernia surgery . We present the case of a 22-year-old man who developed an unspecific and refractory syndrome of inguinal pain after a TAPP procedure for a primary inguinal hernia . Repeated reoperation for removement of clips and nerve transection were unsuccessful . By a transinguinal approach , 18 months after the first operation we removed a preperitoneal Prolene mesh which had shrunk and folded to 30 % of its original size . The problem of biocompatibility of meshes currently used in inguinal hernia surgery is discussed . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O" ]	The implantation of a mesh is an essential step in laparoscopic inguinal hernia surgery . We present the case of a 22-year-old man who developed an unspecific and refractory syndrome of inguinal pain after a TAPP procedure for a primary inguinal hernia . Repeated reoperation for removement of clips and nerve transection were unsuccessful . By a transinguinal approach , 18 months after the first operation we removed a preperitoneal Prolene mesh which had shrunk and folded to 30 % of its original size . The problem of biocompatibility of meshes currently used in inguinal hernia surgery is discussed .	[ "The", "implantation", "of", "a", "mesh", "is", "an", "essential", "step", "in", "laparoscopic", "inguinal", "hernia", "surgery", ".", "We", "present", "the", "case", "of", "a", "22-year", "-", "old", "man", "who", "developed", "an", "unspecific", "and", "refractory", "syndrome", "of", "inguinal", "pain", "after", "a", "TAPP", "procedure", "for", "a", "primary", "inguinal", "hernia", ".", "Repeated", "reoperation", "for", "removement", "of", "clips", "and", "nerve", "transection", "were", "unsuccessful", ".", "By", "a", "transinguinal", "approach", ",", "18", "months", "after", "the", "first", "operation", "we", "removed", "a", "preperitoneal", "Prolene", "mesh", "which", "had", "shrunk", "and", "folded", "to", "30", "%", "of", "its", "original", "size", ".", "The", "problem", "of", "biocompatibility", "of", "meshes", "currently", "used", "in", "inguinal", "hernia", "surgery", "is", "discussed", "." ]	[ "umlsterm" ]
Therapiestrategien is an umlsterm, Pankreaskarzinom is an umlsterm, Karzinome is an umlsterm, Selbst is an umlsterm, Karzinome is an umlsterm, Radiotherapie is an umlsterm, Analyse is an umlsterm, Morbiditaet is an umlsterm, Radiotherapie is an umlsterm, Morbiditaet is an umlsterm, Behandlung is an umlsterm, Tumorkontrolle is an umlsterm, Schmerzbesserung is an umlsterm, Patienten is an umlsterm, Gesamtprognose is an umlsterm, Karzinomen is an umlsterm, Risiko is an umlsterm, Gastrointestinalblutung is an umlsterm	DerRadiologe.60360441.ger.abstr_task0	Sentence: Therapiestrategien beim Pankreaskarzinom werden bestimmt durch den hohen Anteil primaer nicht resektabler Karzinome , der hohen relativen Strahlenresistenz und der hohen Fernmetastasierungsrate . Selbst kurativ resezierte Karzinome erfordern durch ihre hohe lokale Tumorzellpersistenz eine lokal effektive adjuvante Behandlungsmassnahme . Die Effektivitaet einer Radiotherapie ist dosisabhaengig . Aus der Analyse publizierter Daten wird eine Dosis von > 50 Gy , welche bei der alleinigen perkutanen Bestrahlung mit einer hohen Morbiditaet verbunden ist , empfohlen . Mit der intraoperativen Radiotherapie ist eine lokal begrenzte Dosiseskalation ohne erhoehte perioperative Morbiditaet moeglich . Sowohl in der adjuvanten als auch in der primaeren Behandlung kann die lokale Tumorkontrolle deutlich verbessert werden ( 70-90 % ) . Unter palliativen Gesichtspunkten wird eine rasche und langandauernde Schmerzbesserung bei ueber 60 % der Patienten erreicht . Die Gesamtprognose wird jedoch durch die unveraendert hohe Fernmetastasierungsrate sowohl nach kurativer Resektion als auch bei primaerer Inoperabilitaet relativiert . Die weitere Dosiseskalation ist bei inoperablen Karzinomen durch das hohe Risiko ( 20-30 % ) einer Gastrointestinalblutung limitiert . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Therapiestrategien beim Pankreaskarzinom werden bestimmt durch den hohen Anteil primaer nicht resektabler Karzinome , der hohen relativen Strahlenresistenz und der hohen Fernmetastasierungsrate . Selbst kurativ resezierte Karzinome erfordern durch ihre hohe lokale Tumorzellpersistenz eine lokal effektive adjuvante Behandlungsmassnahme . Die Effektivitaet einer Radiotherapie ist dosisabhaengig . Aus der Analyse publizierter Daten wird eine Dosis von > 50 Gy , welche bei der alleinigen perkutanen Bestrahlung mit einer hohen Morbiditaet verbunden ist , empfohlen . Mit der intraoperativen Radiotherapie ist eine lokal begrenzte Dosiseskalation ohne erhoehte perioperative Morbiditaet moeglich . Sowohl in der adjuvanten als auch in der primaeren Behandlung kann die lokale Tumorkontrolle deutlich verbessert werden ( 70-90 % ) . Unter palliativen Gesichtspunkten wird eine rasche und langandauernde Schmerzbesserung bei ueber 60 % der Patienten erreicht . Die Gesamtprognose wird jedoch durch die unveraendert hohe Fernmetastasierungsrate sowohl nach kurativer Resektion als auch bei primaerer Inoperabilitaet relativiert . Die weitere Dosiseskalation ist bei inoperablen Karzinomen durch das hohe Risiko ( 20-30 % ) einer Gastrointestinalblutung limitiert .	[ "Therapiestrategien", "beim", "Pankreaskarzinom", "werden", "bestimmt", "durch", "den", "hohen", "Anteil", "primaer", "nicht", "resektabler", "Karzinome", ",", "der", "hohen", "relativen", "Strahlenresistenz", "und", "der", "hohen", "Fernmetastasierungsrate", ".", "Selbst", "kurativ", "resezierte", "Karzinome", "erfordern", "durch", "ihre", "hohe", "lokale", "Tumorzellpersistenz", "eine", "lokal", "effektive", "adjuvante", "Behandlungsmassnahme", ".", "Die", "Effektivitaet", "einer", "Radiotherapie", "ist", "dosisabhaengig", ".", "Aus", "der", "Analyse", "publizierter", "Daten", "wird", "eine", "Dosis", "von", ">", "50", "Gy", ",", "welche", "bei", "der", "alleinigen", "perkutanen", "Bestrahlung", "mit", "einer", "hohen", "Morbiditaet", "verbunden", "ist", ",", "empfohlen", ".", "Mit", "der", "intraoperativen", "Radiotherapie", "ist", "eine", "lokal", "begrenzte", "Dosiseskalation", "ohne", "erhoehte", "perioperative", "Morbiditaet", "moeglich", ".", "Sowohl", "in", "der", "adjuvanten", "als", "auch", "in", "der", "primaeren", "Behandlung", "kann", "die", "lokale", "Tumorkontrolle", "deutlich", "verbessert", "werden", "(", "70", "-", "90", "%", ")", ".", "Unter", "palliativen", "Gesichtspunkten", "wird", "eine", "rasche", "und", "langandauernde", "Schmerzbesserung", "bei", "ueber", "60", "%", "der", "Patienten", "erreicht", ".", "Die", "Gesamtprognose", "wird", "jedoch", "durch", "die", "unveraendert", "hohe", "Fernmetastasierungsrate", "sowohl", "nach", "kurativer", "Resektion", "als", "auch", "bei", "primaerer", "Inoperabilitaet", "relativiert", ".", "Die", "weitere", "Dosiseskalation", "ist", "bei", "inoperablen", "Karzinomen", "durch", "das", "hohe", "Risiko", "(", "20", "-", "30", "%", ")", "einer", "Gastrointestinalblutung", "limitiert", "." ]	[ "umlsterm" ]
Therapiestrategien is an umlsterm, Pankreaskarzinom is an umlsterm, Karzinome is an umlsterm, Selbst is an umlsterm, Karzinome is an umlsterm, Radiotherapie is an umlsterm, Analyse is an umlsterm, Morbiditaet is an umlsterm, Radiotherapie is an umlsterm, Morbiditaet is an umlsterm, Behandlung is an umlsterm, Tumorkontrolle is an umlsterm, Schmerzbesserung is an umlsterm, Patienten is an umlsterm, Gesamtprognose is an umlsterm, Karzinomen is an umlsterm, Risiko is an umlsterm, Gastrointestinalblutung is an umlsterm	DerRadiologe.60360441.ger.abstr_task1	Sentence: Therapiestrategien beim Pankreaskarzinom werden bestimmt durch den hohen Anteil primaer nicht resektabler Karzinome , der hohen relativen Strahlenresistenz und der hohen Fernmetastasierungsrate . Selbst kurativ resezierte Karzinome erfordern durch ihre hohe lokale Tumorzellpersistenz eine lokal effektive adjuvante Behandlungsmassnahme . Die Effektivitaet einer Radiotherapie ist dosisabhaengig . Aus der Analyse publizierter Daten wird eine Dosis von > 50 Gy , welche bei der alleinigen perkutanen Bestrahlung mit einer hohen Morbiditaet verbunden ist , empfohlen . Mit der intraoperativen Radiotherapie ist eine lokal begrenzte Dosiseskalation ohne erhoehte perioperative Morbiditaet moeglich . Sowohl in der adjuvanten als auch in der primaeren Behandlung kann die lokale Tumorkontrolle deutlich verbessert werden ( 70-90 % ) . Unter palliativen Gesichtspunkten wird eine rasche und langandauernde Schmerzbesserung bei ueber 60 % der Patienten erreicht . Die Gesamtprognose wird jedoch durch die unveraendert hohe Fernmetastasierungsrate sowohl nach kurativer Resektion als auch bei primaerer Inoperabilitaet relativiert . Die weitere Dosiseskalation ist bei inoperablen Karzinomen durch das hohe Risiko ( 20-30 % ) einer Gastrointestinalblutung limitiert . Instructions: please typing these entity words according to sentence: Therapiestrategien, Pankreaskarzinom, Karzinome, Selbst, Karzinome, Radiotherapie, Analyse, Morbiditaet, Radiotherapie, Morbiditaet, Behandlung, Tumorkontrolle, Schmerzbesserung, Patienten, Gesamtprognose, Karzinomen, Risiko, Gastrointestinalblutung Options: umlsterm	[ "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Therapiestrategien beim Pankreaskarzinom werden bestimmt durch den hohen Anteil primaer nicht resektabler Karzinome , der hohen relativen Strahlenresistenz und der hohen Fernmetastasierungsrate . Selbst kurativ resezierte Karzinome erfordern durch ihre hohe lokale Tumorzellpersistenz eine lokal effektive adjuvante Behandlungsmassnahme . Die Effektivitaet einer Radiotherapie ist dosisabhaengig . Aus der Analyse publizierter Daten wird eine Dosis von > 50 Gy , welche bei der alleinigen perkutanen Bestrahlung mit einer hohen Morbiditaet verbunden ist , empfohlen . Mit der intraoperativen Radiotherapie ist eine lokal begrenzte Dosiseskalation ohne erhoehte perioperative Morbiditaet moeglich . Sowohl in der adjuvanten als auch in der primaeren Behandlung kann die lokale Tumorkontrolle deutlich verbessert werden ( 70-90 % ) . Unter palliativen Gesichtspunkten wird eine rasche und langandauernde Schmerzbesserung bei ueber 60 % der Patienten erreicht . Die Gesamtprognose wird jedoch durch die unveraendert hohe Fernmetastasierungsrate sowohl nach kurativer Resektion als auch bei primaerer Inoperabilitaet relativiert . Die weitere Dosiseskalation ist bei inoperablen Karzinomen durch das hohe Risiko ( 20-30 % ) einer Gastrointestinalblutung limitiert .	[ "Therapiestrategien", "beim", "Pankreaskarzinom", "werden", "bestimmt", "durch", "den", "hohen", "Anteil", "primaer", "nicht", "resektabler", "Karzinome", ",", "der", "hohen", "relativen", "Strahlenresistenz", "und", "der", "hohen", "Fernmetastasierungsrate", ".", "Selbst", "kurativ", "resezierte", "Karzinome", "erfordern", "durch", "ihre", "hohe", "lokale", "Tumorzellpersistenz", "eine", "lokal", "effektive", "adjuvante", "Behandlungsmassnahme", ".", "Die", "Effektivitaet", "einer", "Radiotherapie", "ist", "dosisabhaengig", ".", "Aus", "der", "Analyse", "publizierter", "Daten", "wird", "eine", "Dosis", "von", ">", "50", "Gy", ",", "welche", "bei", "der", "alleinigen", "perkutanen", "Bestrahlung", "mit", "einer", "hohen", "Morbiditaet", "verbunden", "ist", ",", "empfohlen", ".", "Mit", "der", "intraoperativen", "Radiotherapie", "ist", "eine", "lokal", "begrenzte", "Dosiseskalation", "ohne", "erhoehte", "perioperative", "Morbiditaet", "moeglich", ".", "Sowohl", "in", "der", "adjuvanten", "als", "auch", "in", "der", "primaeren", "Behandlung", "kann", "die", "lokale", "Tumorkontrolle", "deutlich", "verbessert", "werden", "(", "70", "-", "90", "%", ")", ".", "Unter", "palliativen", "Gesichtspunkten", "wird", "eine", "rasche", "und", "langandauernde", "Schmerzbesserung", "bei", "ueber", "60", "%", "der", "Patienten", "erreicht", ".", "Die", "Gesamtprognose", "wird", "jedoch", "durch", "die", "unveraendert", "hohe", "Fernmetastasierungsrate", "sowohl", "nach", "kurativer", "Resektion", "als", "auch", "bei", "primaerer", "Inoperabilitaet", "relativiert", ".", "Die", "weitere", "Dosiseskalation", "ist", "bei", "inoperablen", "Karzinomen", "durch", "das", "hohe", "Risiko", "(", "20", "-", "30", "%", ")", "einer", "Gastrointestinalblutung", "limitiert", "." ]	[ "umlsterm" ]
Therapiestrategien, Pankreaskarzinom, Karzinome, Selbst, Karzinome, Radiotherapie, Analyse, Morbiditaet, Radiotherapie, Morbiditaet, Behandlung, Tumorkontrolle, Schmerzbesserung, Patienten, Gesamtprognose, Karzinomen, Risiko, Gastrointestinalblutung	DerRadiologe.60360441.ger.abstr_task2	Sentence: Therapiestrategien beim Pankreaskarzinom werden bestimmt durch den hohen Anteil primaer nicht resektabler Karzinome , der hohen relativen Strahlenresistenz und der hohen Fernmetastasierungsrate . Selbst kurativ resezierte Karzinome erfordern durch ihre hohe lokale Tumorzellpersistenz eine lokal effektive adjuvante Behandlungsmassnahme . Die Effektivitaet einer Radiotherapie ist dosisabhaengig . Aus der Analyse publizierter Daten wird eine Dosis von > 50 Gy , welche bei der alleinigen perkutanen Bestrahlung mit einer hohen Morbiditaet verbunden ist , empfohlen . Mit der intraoperativen Radiotherapie ist eine lokal begrenzte Dosiseskalation ohne erhoehte perioperative Morbiditaet moeglich . Sowohl in der adjuvanten als auch in der primaeren Behandlung kann die lokale Tumorkontrolle deutlich verbessert werden ( 70-90 % ) . Unter palliativen Gesichtspunkten wird eine rasche und langandauernde Schmerzbesserung bei ueber 60 % der Patienten erreicht . Die Gesamtprognose wird jedoch durch die unveraendert hohe Fernmetastasierungsrate sowohl nach kurativer Resektion als auch bei primaerer Inoperabilitaet relativiert . Die weitere Dosiseskalation ist bei inoperablen Karzinomen durch das hohe Risiko ( 20-30 % ) einer Gastrointestinalblutung limitiert . Instructions: please extract entity words from the input sentence	[ "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Therapiestrategien beim Pankreaskarzinom werden bestimmt durch den hohen Anteil primaer nicht resektabler Karzinome , der hohen relativen Strahlenresistenz und der hohen Fernmetastasierungsrate . Selbst kurativ resezierte Karzinome erfordern durch ihre hohe lokale Tumorzellpersistenz eine lokal effektive adjuvante Behandlungsmassnahme . Die Effektivitaet einer Radiotherapie ist dosisabhaengig . Aus der Analyse publizierter Daten wird eine Dosis von > 50 Gy , welche bei der alleinigen perkutanen Bestrahlung mit einer hohen Morbiditaet verbunden ist , empfohlen . Mit der intraoperativen Radiotherapie ist eine lokal begrenzte Dosiseskalation ohne erhoehte perioperative Morbiditaet moeglich . Sowohl in der adjuvanten als auch in der primaeren Behandlung kann die lokale Tumorkontrolle deutlich verbessert werden ( 70-90 % ) . Unter palliativen Gesichtspunkten wird eine rasche und langandauernde Schmerzbesserung bei ueber 60 % der Patienten erreicht . Die Gesamtprognose wird jedoch durch die unveraendert hohe Fernmetastasierungsrate sowohl nach kurativer Resektion als auch bei primaerer Inoperabilitaet relativiert . Die weitere Dosiseskalation ist bei inoperablen Karzinomen durch das hohe Risiko ( 20-30 % ) einer Gastrointestinalblutung limitiert .	[ "Therapiestrategien", "beim", "Pankreaskarzinom", "werden", "bestimmt", "durch", "den", "hohen", "Anteil", "primaer", "nicht", "resektabler", "Karzinome", ",", "der", "hohen", "relativen", "Strahlenresistenz", "und", "der", "hohen", "Fernmetastasierungsrate", ".", "Selbst", "kurativ", "resezierte", "Karzinome", "erfordern", "durch", "ihre", "hohe", "lokale", "Tumorzellpersistenz", "eine", "lokal", "effektive", "adjuvante", "Behandlungsmassnahme", ".", "Die", "Effektivitaet", "einer", "Radiotherapie", "ist", "dosisabhaengig", ".", "Aus", "der", "Analyse", "publizierter", "Daten", "wird", "eine", "Dosis", "von", ">", "50", "Gy", ",", "welche", "bei", "der", "alleinigen", "perkutanen", "Bestrahlung", "mit", "einer", "hohen", "Morbiditaet", "verbunden", "ist", ",", "empfohlen", ".", "Mit", "der", "intraoperativen", "Radiotherapie", "ist", "eine", "lokal", "begrenzte", "Dosiseskalation", "ohne", "erhoehte", "perioperative", "Morbiditaet", "moeglich", ".", "Sowohl", "in", "der", "adjuvanten", "als", "auch", "in", "der", "primaeren", "Behandlung", "kann", "die", "lokale", "Tumorkontrolle", "deutlich", "verbessert", "werden", "(", "70", "-", "90", "%", ")", ".", "Unter", "palliativen", "Gesichtspunkten", "wird", "eine", "rasche", "und", "langandauernde", "Schmerzbesserung", "bei", "ueber", "60", "%", "der", "Patienten", "erreicht", ".", "Die", "Gesamtprognose", "wird", "jedoch", "durch", "die", "unveraendert", "hohe", "Fernmetastasierungsrate", "sowohl", "nach", "kurativer", "Resektion", "als", "auch", "bei", "primaerer", "Inoperabilitaet", "relativiert", ".", "Die", "weitere", "Dosiseskalation", "ist", "bei", "inoperablen", "Karzinomen", "durch", "das", "hohe", "Risiko", "(", "20", "-", "30", "%", ")", "einer", "Gastrointestinalblutung", "limitiert", "." ]	[ "umlsterm" ]
sklerafixierten is an umlsterm, Hinterkammerlinse is an umlsterm, Auge is an umlsterm	DerOpthalmologe.80950564.ger.abstr_task0	Sentence: Hintergrund : Die Positionierung einer sklerafixierten Hinterkammerlinse im vitrektomierten Auge stellt wegen der mangelnden Stabilitaet des Bulbus ein chirurgisches Problem dar . Es wird haeufig mit Hilfe eines Flieringa-Ringes zu loesen versucht , Perfluorkarbon scheint demgegenueber aber Vorteile zu bieten . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Hintergrund : Die Positionierung einer sklerafixierten Hinterkammerlinse im vitrektomierten Auge stellt wegen der mangelnden Stabilitaet des Bulbus ein chirurgisches Problem dar . Es wird haeufig mit Hilfe eines Flieringa-Ringes zu loesen versucht , Perfluorkarbon scheint demgegenueber aber Vorteile zu bieten .	[ "Hintergrund", ":", "Die", "Positionierung", "einer", "sklerafixierten", "Hinterkammerlinse", "im", "vitrektomierten", "Auge", "stellt", "wegen", "der", "mangelnden", "Stabilitaet", "des", "Bulbus", "ein", "chirurgisches", "Problem", "dar", ".", "Es", "wird", "haeufig", "mit", "Hilfe", "eines", "Flieringa", "-", "Ringes", "zu", "loesen", "versucht", ",", "Perfluorkarbon", "scheint", "demgegenueber", "aber", "Vorteile", "zu", "bieten", "." ]	[ "umlsterm" ]
sklerafixierten is an umlsterm, Hinterkammerlinse is an umlsterm, Auge is an umlsterm	DerOpthalmologe.80950564.ger.abstr_task1	Sentence: Hintergrund : Die Positionierung einer sklerafixierten Hinterkammerlinse im vitrektomierten Auge stellt wegen der mangelnden Stabilitaet des Bulbus ein chirurgisches Problem dar . Es wird haeufig mit Hilfe eines Flieringa-Ringes zu loesen versucht , Perfluorkarbon scheint demgegenueber aber Vorteile zu bieten . Instructions: please typing these entity words according to sentence: sklerafixierten, Hinterkammerlinse, Auge Options: umlsterm	[ "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Hintergrund : Die Positionierung einer sklerafixierten Hinterkammerlinse im vitrektomierten Auge stellt wegen der mangelnden Stabilitaet des Bulbus ein chirurgisches Problem dar . Es wird haeufig mit Hilfe eines Flieringa-Ringes zu loesen versucht , Perfluorkarbon scheint demgegenueber aber Vorteile zu bieten .	[ "Hintergrund", ":", "Die", "Positionierung", "einer", "sklerafixierten", "Hinterkammerlinse", "im", "vitrektomierten", "Auge", "stellt", "wegen", "der", "mangelnden", "Stabilitaet", "des", "Bulbus", "ein", "chirurgisches", "Problem", "dar", ".", "Es", "wird", "haeufig", "mit", "Hilfe", "eines", "Flieringa", "-", "Ringes", "zu", "loesen", "versucht", ",", "Perfluorkarbon", "scheint", "demgegenueber", "aber", "Vorteile", "zu", "bieten", "." ]	[ "umlsterm" ]
sklerafixierten, Hinterkammerlinse, Auge	DerOpthalmologe.80950564.ger.abstr_task2	Sentence: Hintergrund : Die Positionierung einer sklerafixierten Hinterkammerlinse im vitrektomierten Auge stellt wegen der mangelnden Stabilitaet des Bulbus ein chirurgisches Problem dar . Es wird haeufig mit Hilfe eines Flieringa-Ringes zu loesen versucht , Perfluorkarbon scheint demgegenueber aber Vorteile zu bieten . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Hintergrund : Die Positionierung einer sklerafixierten Hinterkammerlinse im vitrektomierten Auge stellt wegen der mangelnden Stabilitaet des Bulbus ein chirurgisches Problem dar . Es wird haeufig mit Hilfe eines Flieringa-Ringes zu loesen versucht , Perfluorkarbon scheint demgegenueber aber Vorteile zu bieten .	[ "Hintergrund", ":", "Die", "Positionierung", "einer", "sklerafixierten", "Hinterkammerlinse", "im", "vitrektomierten", "Auge", "stellt", "wegen", "der", "mangelnden", "Stabilitaet", "des", "Bulbus", "ein", "chirurgisches", "Problem", "dar", ".", "Es", "wird", "haeufig", "mit", "Hilfe", "eines", "Flieringa", "-", "Ringes", "zu", "loesen", "versucht", ",", "Perfluorkarbon", "scheint", "demgegenueber", "aber", "Vorteile", "zu", "bieten", "." ]	[ "umlsterm" ]
amoxicilina / ácido clavulánico is a NORMALIZABLES, tobramicina is a NORMALIZABLES, aciclovir is a NORMALIZABLES, látex is a NORMALIZABLES, fibrina is a PROTEINAS, PAS is a NORMALIZABLES	440_task0	Sentence: Niño de ocho años natural y residente en Sierra Leona que consultó al hospital Saint John of God en Sierra Leona por una tumoración en el párpado inferior del ojo izquierdo con un tiempo de evolución de alrededor de un mes. El padre refería un antecedente de contacto con hojas de la papaya. Durante la exploración presentaba una tumoración dura que ocupaba los dos tercios externos del párpado inferior izquierdo, con ulceraciones en la superficie cutánea y en la mucosa de dicho párpado. También existían adenopatías en ambos lados del cuello. El resto de la exploración no presentaba datos relevantes. La imposibilidad de realizar cultivos microbiológicos en el terreno obligó a administrar una cobertura antibiótica sistémica y local como primera opción terapéutica por si se trataba de un proceso infeccioso. Se administró amoxicilina/ácido clavulánico por vía oral, y tobramicina y aciclovir tópicos. Pero el síntoma que más destacaba era la consistencia pétrea de la tumoración, junto con las adenopatías regionales que sugerían un proceso neoformativo. Finalmente, el contacto con la papaya hizo considerar la posibilidad de que se tratara de una dermatitis de contacto al látex que exudan estos frutos cuando están verdes1. Se realizó una biopsia cutánea, que se envió a un hospital de referencia. El estudio anatomopatológico mostró un exudado con fibrina y polinucleares en la zona superficial de la úlcera y un tejido de granulación en las regiones profundas, donde se identificaron histiocitos con inclusiones intranucleares de tipo herpético y células multinucleadas gigantes con núcleos que conenían cuerpos de inclusión intranucleares. El músculo esquelético de la zona más profunda de la biopsia mostraba una reacción inflamatoria focal no específica. La tinción de PAS fue negativa. El diagnóstico fue: lesión ulcerada de características compatibles con infección por herpes virus, acompañada de sobreinfección probablemente bacteriana. A las tres semanas, la tumoración del párpado inferior empezó a disminuir de tamaño, así como la induración, al tiempo que cicatrizaron las ulceraciones. Al mes y medio, la reparación era total. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: NORMALIZABLES, PROTEINAS	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "I-NORMALIZABLES", "I-NORMALIZABLES", "I-NORMALIZABLES", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Niño de ocho años natural y residente en Sierra Leona que consultó al hospital Saint John of God en Sierra Leona por una tumoración en el párpado inferior del ojo izquierdo con un tiempo de evolución de alrededor de un mes. El padre refería un antecedente de contacto con hojas de la papaya. Durante la exploración presentaba una tumoración dura que ocupaba los dos tercios externos del párpado inferior izquierdo, con ulceraciones en la superficie cutánea y en la mucosa de dicho párpado. También existían adenopatías en ambos lados del cuello. El resto de la exploración no presentaba datos relevantes. La imposibilidad de realizar cultivos microbiológicos en el terreno obligó a administrar una cobertura antibiótica sistémica y local como primera opción terapéutica por si se trataba de un proceso infeccioso. Se administró amoxicilina/ácido clavulánico por vía oral, y tobramicina y aciclovir tópicos. Pero el síntoma que más destacaba era la consistencia pétrea de la tumoración, junto con las adenopatías regionales que sugerían un proceso neoformativo. Finalmente, el contacto con la papaya hizo considerar la posibilidad de que se tratara de una dermatitis de contacto al látex que exudan estos frutos cuando están verdes1. Se realizó una biopsia cutánea, que se envió a un hospital de referencia. El estudio anatomopatológico mostró un exudado con fibrina y polinucleares en la zona superficial de la úlcera y un tejido de granulación en las regiones profundas, donde se identificaron histiocitos con inclusiones intranucleares de tipo herpético y células multinucleadas gigantes con núcleos que conenían cuerpos de inclusión intranucleares. El músculo esquelético de la zona más profunda de la biopsia mostraba una reacción inflamatoria focal no específica. La tinción de PAS fue negativa. El diagnóstico fue: lesión ulcerada de características compatibles con infección por herpes virus, acompañada de sobreinfección probablemente bacteriana. A las tres semanas, la tumoración del párpado inferior empezó a disminuir de tamaño, así como la induración, al tiempo que cicatrizaron las ulceraciones. Al mes y medio, la reparación era total.	[ "Niño", "de", "ocho", "años", "natural", "y", "residente", "en", "Sierra", "Leona", "que", "consultó", "al", "hospital", "Saint", "John", "of", "God", "en", "Sierra", "Leona", "por", "una", "tumoración", "en", "el", "párpado", "inferior", "del", "ojo", "izquierdo", "con", "un", "tiempo", "de", "evolución", "de", "alrededor", "de", "un", "mes", ".", "El", "padre", "refería", "un", "antecedente", "de", "contacto", "con", "hojas", "de", "la", "papaya", ".", "\n", "Durante", "la", "exploración", "presentaba", "una", "tumoración", "dura", "que", "ocupaba", "los", "dos", "tercios", "externos", "del", "párpado", "inferior", "izquierdo", ",", "con", "ulceraciones", "en", "la", "superficie", "cutánea", "y", "en", "la", "mucosa", "de", "dicho", "párpado", ".", "También", "existían", "adenopatías", "en", "ambos", "lados", "del", "cuello", ".", "El", "resto", "de", "la", "exploración", "no", "presentaba", "datos", "relevantes", ".", "\n\n", "La", "imposibilidad", "de", "realizar", "cultivos", "microbiológicos", "en", "el", "terreno", "obligó", "a", "administrar", "una", "cobertura", "antibiótica", "sistémica", "y", "local", "como", "primera", "opción", "terapéutica", "por", "si", "se", "trataba", "de", "un", "proceso", "infeccioso", ".", "Se", "administró", "amoxicilina", "/", "ácido", "clavulánico", "por", "vía", "oral", ",", "y", "tobramicina", "y", "aciclovir", "tópicos", ".", "Pero", "el", "síntoma", "que", "más", "destacaba", "era", "la", "consistencia", "pétrea", "de", "la", "tumoración", ",", "junto", "con", "las", "adenopatías", "regionales", "que", "sugerían", "un", "proceso", "neoformativo", ".", "Finalmente", ",", "el", "contacto", "con", "la", "papaya", "hizo", "considerar", "la", "posibilidad", "de", "que", "se", "tratara", "de", "una", "dermatitis", "de", "contacto", "al", "látex", "que", "exudan", "estos", "frutos", "cuando", "están", "verdes1", ".", "Se", "realizó", "una", "biopsia", "cutánea", ",", "que", "se", "envió", "a", "un", "hospital", "de", "referencia", ".", "\n", "El", "estudio", "anatomopatológico", "mostró", "un", "exudado", "con", "fibrina", "y", "polinucleares", "en", "la", "zona", "superficial", "de", "la", "úlcera", "y", "un", "tejido", "de", "granulación", "en", "las", "regiones", "profundas", ",", "donde", "se", "identificaron", "histiocitos", "con", "inclusiones", "intranucleares", "de", "tipo", "herpético", "y", "células", "multinucleadas", "gigantes", "con", "núcleos", "que", "conenían", "cuerpos", "de", "inclusión", "intranucleares", ".", "El", "músculo", "esquelético", "de", "la", "zona", "más", "profunda", "de", "la", "biopsia", "mostraba", "una", "reacción", "inflamatoria", "focal", "no", "específica", ".", "La", "tinción", "de", "PAS", "fue", "negativa", ".", "El", "diagnóstico", "fue", ":", "lesión", "ulcerada", "de", "características", "compatibles", "con", "infección", "por", "herpes", "virus", ",", "acompañada", "de", "sobreinfección", "probablemente", "bacteriana", ".", "\n\n", "A", "las", "tres", "semanas", ",", "la", "tumoración", "del", "párpado", "inferior", "empezó", "a", "disminuir", "de", "tamaño", ",", "así", "como", "la", "induración", ",", "al", "tiempo", "que", "cicatrizaron", "las", "ulceraciones", ".", "Al", "mes", "y", "medio", ",", "la", "reparación", "era", "total", ".", "\n\n" ]	[ "NORMALIZABLES", "PROTEINAS" ]
amoxicilina / ácido clavulánico is a NORMALIZABLES, tobramicina is a NORMALIZABLES, aciclovir is a NORMALIZABLES, látex is a NORMALIZABLES, fibrina is a PROTEINAS, PAS is a NORMALIZABLES	440_task1	Sentence: Niño de ocho años natural y residente en Sierra Leona que consultó al hospital Saint John of God en Sierra Leona por una tumoración en el párpado inferior del ojo izquierdo con un tiempo de evolución de alrededor de un mes. El padre refería un antecedente de contacto con hojas de la papaya. Durante la exploración presentaba una tumoración dura que ocupaba los dos tercios externos del párpado inferior izquierdo, con ulceraciones en la superficie cutánea y en la mucosa de dicho párpado. También existían adenopatías en ambos lados del cuello. El resto de la exploración no presentaba datos relevantes. La imposibilidad de realizar cultivos microbiológicos en el terreno obligó a administrar una cobertura antibiótica sistémica y local como primera opción terapéutica por si se trataba de un proceso infeccioso. Se administró amoxicilina/ácido clavulánico por vía oral, y tobramicina y aciclovir tópicos. Pero el síntoma que más destacaba era la consistencia pétrea de la tumoración, junto con las adenopatías regionales que sugerían un proceso neoformativo. Finalmente, el contacto con la papaya hizo considerar la posibilidad de que se tratara de una dermatitis de contacto al látex que exudan estos frutos cuando están verdes1. Se realizó una biopsia cutánea, que se envió a un hospital de referencia. El estudio anatomopatológico mostró un exudado con fibrina y polinucleares en la zona superficial de la úlcera y un tejido de granulación en las regiones profundas, donde se identificaron histiocitos con inclusiones intranucleares de tipo herpético y células multinucleadas gigantes con núcleos que conenían cuerpos de inclusión intranucleares. El músculo esquelético de la zona más profunda de la biopsia mostraba una reacción inflamatoria focal no específica. La tinción de PAS fue negativa. El diagnóstico fue: lesión ulcerada de características compatibles con infección por herpes virus, acompañada de sobreinfección probablemente bacteriana. A las tres semanas, la tumoración del párpado inferior empezó a disminuir de tamaño, así como la induración, al tiempo que cicatrizaron las ulceraciones. Al mes y medio, la reparación era total. Instructions: please typing these entity words according to sentence: amoxicilina / ácido clavulánico, tobramicina, aciclovir, látex, fibrina, PAS Options: NORMALIZABLES, PROTEINAS	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "I-NORMALIZABLES", "I-NORMALIZABLES", "I-NORMALIZABLES", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Niño de ocho años natural y residente en Sierra Leona que consultó al hospital Saint John of God en Sierra Leona por una tumoración en el párpado inferior del ojo izquierdo con un tiempo de evolución de alrededor de un mes. El padre refería un antecedente de contacto con hojas de la papaya. Durante la exploración presentaba una tumoración dura que ocupaba los dos tercios externos del párpado inferior izquierdo, con ulceraciones en la superficie cutánea y en la mucosa de dicho párpado. También existían adenopatías en ambos lados del cuello. El resto de la exploración no presentaba datos relevantes. La imposibilidad de realizar cultivos microbiológicos en el terreno obligó a administrar una cobertura antibiótica sistémica y local como primera opción terapéutica por si se trataba de un proceso infeccioso. Se administró amoxicilina/ácido clavulánico por vía oral, y tobramicina y aciclovir tópicos. Pero el síntoma que más destacaba era la consistencia pétrea de la tumoración, junto con las adenopatías regionales que sugerían un proceso neoformativo. Finalmente, el contacto con la papaya hizo considerar la posibilidad de que se tratara de una dermatitis de contacto al látex que exudan estos frutos cuando están verdes1. Se realizó una biopsia cutánea, que se envió a un hospital de referencia. El estudio anatomopatológico mostró un exudado con fibrina y polinucleares en la zona superficial de la úlcera y un tejido de granulación en las regiones profundas, donde se identificaron histiocitos con inclusiones intranucleares de tipo herpético y células multinucleadas gigantes con núcleos que conenían cuerpos de inclusión intranucleares. El músculo esquelético de la zona más profunda de la biopsia mostraba una reacción inflamatoria focal no específica. La tinción de PAS fue negativa. El diagnóstico fue: lesión ulcerada de características compatibles con infección por herpes virus, acompañada de sobreinfección probablemente bacteriana. A las tres semanas, la tumoración del párpado inferior empezó a disminuir de tamaño, así como la induración, al tiempo que cicatrizaron las ulceraciones. Al mes y medio, la reparación era total.	[ "Niño", "de", "ocho", "años", "natural", "y", "residente", "en", "Sierra", "Leona", "que", "consultó", "al", "hospital", "Saint", "John", "of", "God", "en", "Sierra", "Leona", "por", "una", "tumoración", "en", "el", "párpado", "inferior", "del", "ojo", "izquierdo", "con", "un", "tiempo", "de", "evolución", "de", "alrededor", "de", "un", "mes", ".", "El", "padre", "refería", "un", "antecedente", "de", "contacto", "con", "hojas", "de", "la", "papaya", ".", "\n", "Durante", "la", "exploración", "presentaba", "una", "tumoración", "dura", "que", "ocupaba", "los", "dos", "tercios", "externos", "del", "párpado", "inferior", "izquierdo", ",", "con", "ulceraciones", "en", "la", "superficie", "cutánea", "y", "en", "la", "mucosa", "de", "dicho", "párpado", ".", "También", "existían", "adenopatías", "en", "ambos", "lados", "del", "cuello", ".", "El", "resto", "de", "la", "exploración", "no", "presentaba", "datos", "relevantes", ".", "\n\n", "La", "imposibilidad", "de", "realizar", "cultivos", "microbiológicos", "en", "el", "terreno", "obligó", "a", "administrar", "una", "cobertura", "antibiótica", "sistémica", "y", "local", "como", "primera", "opción", "terapéutica", "por", "si", "se", "trataba", "de", "un", "proceso", "infeccioso", ".", "Se", "administró", "amoxicilina", "/", "ácido", "clavulánico", "por", "vía", "oral", ",", "y", "tobramicina", "y", "aciclovir", "tópicos", ".", "Pero", "el", "síntoma", "que", "más", "destacaba", "era", "la", "consistencia", "pétrea", "de", "la", "tumoración", ",", "junto", "con", "las", "adenopatías", "regionales", "que", "sugerían", "un", "proceso", "neoformativo", ".", "Finalmente", ",", "el", "contacto", "con", "la", "papaya", "hizo", "considerar", "la", "posibilidad", "de", "que", "se", "tratara", "de", "una", "dermatitis", "de", "contacto", "al", "látex", "que", "exudan", "estos", "frutos", "cuando", "están", "verdes1", ".", "Se", "realizó", "una", "biopsia", "cutánea", ",", "que", "se", "envió", "a", "un", "hospital", "de", "referencia", ".", "\n", "El", "estudio", "anatomopatológico", "mostró", "un", "exudado", "con", "fibrina", "y", "polinucleares", "en", "la", "zona", "superficial", "de", "la", "úlcera", "y", "un", "tejido", "de", "granulación", "en", "las", "regiones", "profundas", ",", "donde", "se", "identificaron", "histiocitos", "con", "inclusiones", "intranucleares", "de", "tipo", "herpético", "y", "células", "multinucleadas", "gigantes", "con", "núcleos", "que", "conenían", "cuerpos", "de", "inclusión", "intranucleares", ".", "El", "músculo", "esquelético", "de", "la", "zona", "más", "profunda", "de", "la", "biopsia", "mostraba", "una", "reacción", "inflamatoria", "focal", "no", "específica", ".", "La", "tinción", "de", "PAS", "fue", "negativa", ".", "El", "diagnóstico", "fue", ":", "lesión", "ulcerada", "de", "características", "compatibles", "con", "infección", "por", "herpes", "virus", ",", "acompañada", "de", "sobreinfección", "probablemente", "bacteriana", ".", "\n\n", "A", "las", "tres", "semanas", ",", "la", "tumoración", "del", "párpado", "inferior", "empezó", "a", "disminuir", "de", "tamaño", ",", "así", "como", "la", "induración", ",", "al", "tiempo", "que", "cicatrizaron", "las", "ulceraciones", ".", "Al", "mes", "y", "medio", ",", "la", "reparación", "era", "total", ".", "\n\n" ]	[ "NORMALIZABLES", "PROTEINAS" ]
amoxicilina / ácido clavulánico, tobramicina, aciclovir, látex, fibrina, PAS	440_task2	Sentence: Niño de ocho años natural y residente en Sierra Leona que consultó al hospital Saint John of God en Sierra Leona por una tumoración en el párpado inferior del ojo izquierdo con un tiempo de evolución de alrededor de un mes. El padre refería un antecedente de contacto con hojas de la papaya. Durante la exploración presentaba una tumoración dura que ocupaba los dos tercios externos del párpado inferior izquierdo, con ulceraciones en la superficie cutánea y en la mucosa de dicho párpado. También existían adenopatías en ambos lados del cuello. El resto de la exploración no presentaba datos relevantes. La imposibilidad de realizar cultivos microbiológicos en el terreno obligó a administrar una cobertura antibiótica sistémica y local como primera opción terapéutica por si se trataba de un proceso infeccioso. Se administró amoxicilina/ácido clavulánico por vía oral, y tobramicina y aciclovir tópicos. Pero el síntoma que más destacaba era la consistencia pétrea de la tumoración, junto con las adenopatías regionales que sugerían un proceso neoformativo. Finalmente, el contacto con la papaya hizo considerar la posibilidad de que se tratara de una dermatitis de contacto al látex que exudan estos frutos cuando están verdes1. Se realizó una biopsia cutánea, que se envió a un hospital de referencia. El estudio anatomopatológico mostró un exudado con fibrina y polinucleares en la zona superficial de la úlcera y un tejido de granulación en las regiones profundas, donde se identificaron histiocitos con inclusiones intranucleares de tipo herpético y células multinucleadas gigantes con núcleos que conenían cuerpos de inclusión intranucleares. El músculo esquelético de la zona más profunda de la biopsia mostraba una reacción inflamatoria focal no específica. La tinción de PAS fue negativa. El diagnóstico fue: lesión ulcerada de características compatibles con infección por herpes virus, acompañada de sobreinfección probablemente bacteriana. A las tres semanas, la tumoración del párpado inferior empezó a disminuir de tamaño, así como la induración, al tiempo que cicatrizaron las ulceraciones. Al mes y medio, la reparación era total. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "I-NORMALIZABLES", "I-NORMALIZABLES", "I-NORMALIZABLES", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Niño de ocho años natural y residente en Sierra Leona que consultó al hospital Saint John of God en Sierra Leona por una tumoración en el párpado inferior del ojo izquierdo con un tiempo de evolución de alrededor de un mes. El padre refería un antecedente de contacto con hojas de la papaya. Durante la exploración presentaba una tumoración dura que ocupaba los dos tercios externos del párpado inferior izquierdo, con ulceraciones en la superficie cutánea y en la mucosa de dicho párpado. También existían adenopatías en ambos lados del cuello. El resto de la exploración no presentaba datos relevantes. La imposibilidad de realizar cultivos microbiológicos en el terreno obligó a administrar una cobertura antibiótica sistémica y local como primera opción terapéutica por si se trataba de un proceso infeccioso. Se administró amoxicilina/ácido clavulánico por vía oral, y tobramicina y aciclovir tópicos. Pero el síntoma que más destacaba era la consistencia pétrea de la tumoración, junto con las adenopatías regionales que sugerían un proceso neoformativo. Finalmente, el contacto con la papaya hizo considerar la posibilidad de que se tratara de una dermatitis de contacto al látex que exudan estos frutos cuando están verdes1. Se realizó una biopsia cutánea, que se envió a un hospital de referencia. El estudio anatomopatológico mostró un exudado con fibrina y polinucleares en la zona superficial de la úlcera y un tejido de granulación en las regiones profundas, donde se identificaron histiocitos con inclusiones intranucleares de tipo herpético y células multinucleadas gigantes con núcleos que conenían cuerpos de inclusión intranucleares. El músculo esquelético de la zona más profunda de la biopsia mostraba una reacción inflamatoria focal no específica. La tinción de PAS fue negativa. El diagnóstico fue: lesión ulcerada de características compatibles con infección por herpes virus, acompañada de sobreinfección probablemente bacteriana. A las tres semanas, la tumoración del párpado inferior empezó a disminuir de tamaño, así como la induración, al tiempo que cicatrizaron las ulceraciones. Al mes y medio, la reparación era total.	[ "Niño", "de", "ocho", "años", "natural", "y", "residente", "en", "Sierra", "Leona", "que", "consultó", "al", "hospital", "Saint", "John", "of", "God", "en", "Sierra", "Leona", "por", "una", "tumoración", "en", "el", "párpado", "inferior", "del", "ojo", "izquierdo", "con", "un", "tiempo", "de", "evolución", "de", "alrededor", "de", "un", "mes", ".", "El", "padre", "refería", "un", "antecedente", "de", "contacto", "con", "hojas", "de", "la", "papaya", ".", "\n", "Durante", "la", "exploración", "presentaba", "una", "tumoración", "dura", "que", "ocupaba", "los", "dos", "tercios", "externos", "del", "párpado", "inferior", "izquierdo", ",", "con", "ulceraciones", "en", "la", "superficie", "cutánea", "y", "en", "la", "mucosa", "de", "dicho", "párpado", ".", "También", "existían", "adenopatías", "en", "ambos", "lados", "del", "cuello", ".", "El", "resto", "de", "la", "exploración", "no", "presentaba", "datos", "relevantes", ".", "\n\n", "La", "imposibilidad", "de", "realizar", "cultivos", "microbiológicos", "en", "el", "terreno", "obligó", "a", "administrar", "una", "cobertura", "antibiótica", "sistémica", "y", "local", "como", "primera", "opción", "terapéutica", "por", "si", "se", "trataba", "de", "un", "proceso", "infeccioso", ".", "Se", "administró", "amoxicilina", "/", "ácido", "clavulánico", "por", "vía", "oral", ",", "y", "tobramicina", "y", "aciclovir", "tópicos", ".", "Pero", "el", "síntoma", "que", "más", "destacaba", "era", "la", "consistencia", "pétrea", "de", "la", "tumoración", ",", "junto", "con", "las", "adenopatías", "regionales", "que", "sugerían", "un", "proceso", "neoformativo", ".", "Finalmente", ",", "el", "contacto", "con", "la", "papaya", "hizo", "considerar", "la", "posibilidad", "de", "que", "se", "tratara", "de", "una", "dermatitis", "de", "contacto", "al", "látex", "que", "exudan", "estos", "frutos", "cuando", "están", "verdes1", ".", "Se", "realizó", "una", "biopsia", "cutánea", ",", "que", "se", "envió", "a", "un", "hospital", "de", "referencia", ".", "\n", "El", "estudio", "anatomopatológico", "mostró", "un", "exudado", "con", "fibrina", "y", "polinucleares", "en", "la", "zona", "superficial", "de", "la", "úlcera", "y", "un", "tejido", "de", "granulación", "en", "las", "regiones", "profundas", ",", "donde", "se", "identificaron", "histiocitos", "con", "inclusiones", "intranucleares", "de", "tipo", "herpético", "y", "células", "multinucleadas", "gigantes", "con", "núcleos", "que", "conenían", "cuerpos", "de", "inclusión", "intranucleares", ".", "El", "músculo", "esquelético", "de", "la", "zona", "más", "profunda", "de", "la", "biopsia", "mostraba", "una", "reacción", "inflamatoria", "focal", "no", "específica", ".", "La", "tinción", "de", "PAS", "fue", "negativa", ".", "El", "diagnóstico", "fue", ":", "lesión", "ulcerada", "de", "características", "compatibles", "con", "infección", "por", "herpes", "virus", ",", "acompañada", "de", "sobreinfección", "probablemente", "bacteriana", ".", "\n\n", "A", "las", "tres", "semanas", ",", "la", "tumoración", "del", "párpado", "inferior", "empezó", "a", "disminuir", "de", "tamaño", ",", "así", "como", "la", "induración", ",", "al", "tiempo", "que", "cicatrizaron", "las", "ulceraciones", ".", "Al", "mes", "y", "medio", ",", "la", "reparación", "era", "total", ".", "\n\n" ]	[ "NORMALIZABLES", "PROTEINAS" ]
Age is a Person, 18 to 75 years old is a Value, male or female is a Scope, posterior or posterolateral is a Scope, disc herniations is a Condition, one level between L1 and S1 is a Qualifier, radiographic confirmation is a Qualifier, neural compression is a Condition, CT and / or MRI is a Scope, At least six ( 6 ) weeks is a Multiplier, failed is a Qualifier, conservative is a Qualifier, treatment is a Procedure, prior to surgery is a Temporal, immediate is a Qualifier, surgery is a Procedure, prevent is a Mood, permanent disability is a Condition, posterior disc height is a Measurement, index level(s ) is a Qualifier, Lower back pain and / or sciatica is a Scope, spinal claudication is a Condition, Oswestry Questionnaire score is a Measurement, at least 40/100 is a Value, at baseline is a Temporal, VAS leg pain is a Measurement, at least 40/100 is a Value, at baseline is a Temporal	NCT03366779_inc_task0	Sentence: Age 18 to 75 years old (male or female). Patients with posterior or posterolateral disc herniations at one level between L1 and S1 with radiographic confirmation of neural compression using CT and/or MRI. At least six (6) weeks of failed, conservative treatment prior to surgery, or requires immediate surgery to prevent permanent disability. Minimum posterior disc height of 5mm at the index level(s). Lower back pain and/or sciatica with or without spinal claudication. Oswestry Questionnaire score of at least 40/100 at baseline. VAS leg pain of at least 40/100 at baseline. Psychosocially, mentally and physically able to fully comply with the clinical protocol and willing to adhere to follow-up schedule and requirements. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Temporal, Condition, Qualifier, Value, Person, Multiplier, Procedure, Scope, Measurement, Mood	[ "B-Person", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "B-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "B-Condition", "I-Condition", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "B-Qualifier", "I-Qualifier", "O", "B-Condition", "I-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "B-Multiplier", "I-Multiplier", "I-Multiplier", "I-Multiplier", "I-Multiplier", "I-Multiplier", "I-Multiplier", "O", "B-Qualifier", "O", "B-Qualifier", "B-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "B-Qualifier", "B-Procedure", "O", "B-Mood", "B-Condition", "I-Condition", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "O", "O", "O", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "I-Value", "B-Temporal", "I-Temporal", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "I-Value", "B-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Age 18 to 75 years old (male or female). Patients with posterior or posterolateral disc herniations at one level between L1 and S1 with radiographic confirmation of neural compression using CT and/or MRI. At least six (6) weeks of failed, conservative treatment prior to surgery, or requires immediate surgery to prevent permanent disability. Minimum posterior disc height of 5mm at the index level(s). Lower back pain and/or sciatica with or without spinal claudication. Oswestry Questionnaire score of at least 40/100 at baseline. VAS leg pain of at least 40/100 at baseline. Psychosocially, mentally and physically able to fully comply with the clinical protocol and willing to adhere to follow-up schedule and requirements.	[ "Age", "18", "to", "75", "years", "old", "(", "male", "or", "female", ")", ".", "\n", "Patients", "with", "posterior", "or", "posterolateral", "disc", "herniations", "at", "one", "level", "between", "L1", "and", "S1", "with", "radiographic", "confirmation", "of", "neural", "compression", "using", "CT", "and", "/", "or", "MRI", ".", "\n", "At", "least", "six", "(", "6", ")", "weeks", "of", "failed", ",", "conservative", "treatment", "prior", "to", "surgery", ",", "or", "requires", "immediate", "surgery", "to", "prevent", "permanent", "disability", ".", "\n", "Minimum", "posterior", "disc", "height", "of", "5", "mm", "at", "the", "index", "level(s", ")", ".", "\n", "Lower", "back", "pain", "and", "/", "or", "sciatica", "with", "or", "without", "spinal", "claudication", ".", "\n", "Oswestry", "Questionnaire", "score", "of", "at", "least", "40/100", "at", "baseline", ".", "\n", "VAS", "leg", "pain", "of", "at", "least", "40/100", "at", "baseline", ".", "\n", "Psychosocially", ",", "mentally", "and", "physically", "able", "to", "fully", "comply", "with", "the", "clinical", "protocol", "and", "willing", "to", "adhere", "to", "follow", "-", "up", "schedule", "and", "requirements", ".", "\n" ]	[ "Scope", "Measurement", "Qualifier", "Multiplier", "Condition", "Value", "Temporal", "Procedure", "Mood", "Person" ]
Age is a Person, 18 to 75 years old is a Value, male or female is a Scope, posterior or posterolateral is a Scope, disc herniations is a Condition, one level between L1 and S1 is a Qualifier, radiographic confirmation is a Qualifier, neural compression is a Condition, CT and / or MRI is a Scope, At least six ( 6 ) weeks is a Multiplier, failed is a Qualifier, conservative is a Qualifier, treatment is a Procedure, prior to surgery is a Temporal, immediate is a Qualifier, surgery is a Procedure, prevent is a Mood, permanent disability is a Condition, posterior disc height is a Measurement, index level(s ) is a Qualifier, Lower back pain and / or sciatica is a Scope, spinal claudication is a Condition, Oswestry Questionnaire score is a Measurement, at least 40/100 is a Value, at baseline is a Temporal, VAS leg pain is a Measurement, at least 40/100 is a Value, at baseline is a Temporal	NCT03366779_inc_task1	Sentence: Age 18 to 75 years old (male or female). Patients with posterior or posterolateral disc herniations at one level between L1 and S1 with radiographic confirmation of neural compression using CT and/or MRI. At least six (6) weeks of failed, conservative treatment prior to surgery, or requires immediate surgery to prevent permanent disability. Minimum posterior disc height of 5mm at the index level(s). Lower back pain and/or sciatica with or without spinal claudication. Oswestry Questionnaire score of at least 40/100 at baseline. VAS leg pain of at least 40/100 at baseline. Psychosocially, mentally and physically able to fully comply with the clinical protocol and willing to adhere to follow-up schedule and requirements. Instructions: please typing these entity words according to sentence: Age, 18 to 75 years old, male or female, posterior or posterolateral, disc herniations, one level between L1 and S1, radiographic confirmation, neural compression, CT and / or MRI, At least six ( 6 ) weeks, failed, conservative, treatment, prior to surgery, immediate, surgery, prevent, permanent disability, posterior disc height, index level(s ), Lower back pain and / or sciatica, spinal claudication, Oswestry Questionnaire score, at least 40/100, at baseline, VAS leg pain, at least 40/100, at baseline Options: Temporal, Condition, Qualifier, Value, Person, Multiplier, Procedure, Scope, Measurement, Mood	[ "B-Person", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "B-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "B-Condition", "I-Condition", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "B-Qualifier", "I-Qualifier", "O", "B-Condition", "I-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "B-Multiplier", "I-Multiplier", "I-Multiplier", "I-Multiplier", "I-Multiplier", "I-Multiplier", "I-Multiplier", "O", "B-Qualifier", "O", "B-Qualifier", "B-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "B-Qualifier", "B-Procedure", "O", "B-Mood", "B-Condition", "I-Condition", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "O", "O", "O", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "I-Value", "B-Temporal", "I-Temporal", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "I-Value", "B-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Age 18 to 75 years old (male or female). Patients with posterior or posterolateral disc herniations at one level between L1 and S1 with radiographic confirmation of neural compression using CT and/or MRI. At least six (6) weeks of failed, conservative treatment prior to surgery, or requires immediate surgery to prevent permanent disability. Minimum posterior disc height of 5mm at the index level(s). Lower back pain and/or sciatica with or without spinal claudication. Oswestry Questionnaire score of at least 40/100 at baseline. VAS leg pain of at least 40/100 at baseline. Psychosocially, mentally and physically able to fully comply with the clinical protocol and willing to adhere to follow-up schedule and requirements.	[ "Age", "18", "to", "75", "years", "old", "(", "male", "or", "female", ")", ".", "\n", "Patients", "with", "posterior", "or", "posterolateral", "disc", "herniations", "at", "one", "level", "between", "L1", "and", "S1", "with", "radiographic", "confirmation", "of", "neural", "compression", "using", "CT", "and", "/", "or", "MRI", ".", "\n", "At", "least", "six", "(", "6", ")", "weeks", "of", "failed", ",", "conservative", "treatment", "prior", "to", "surgery", ",", "or", "requires", "immediate", "surgery", "to", "prevent", "permanent", "disability", ".", "\n", "Minimum", "posterior", "disc", "height", "of", "5", "mm", "at", "the", "index", "level(s", ")", ".", "\n", "Lower", "back", "pain", "and", "/", "or", "sciatica", "with", "or", "without", "spinal", "claudication", ".", "\n", "Oswestry", "Questionnaire", "score", "of", "at", "least", "40/100", "at", "baseline", ".", "\n", "VAS", "leg", "pain", "of", "at", "least", "40/100", "at", "baseline", ".", "\n", "Psychosocially", ",", "mentally", "and", "physically", "able", "to", "fully", "comply", "with", "the", "clinical", "protocol", "and", "willing", "to", "adhere", "to", "follow", "-", "up", "schedule", "and", "requirements", ".", "\n" ]	[ "Scope", "Measurement", "Qualifier", "Multiplier", "Condition", "Value", "Temporal", "Procedure", "Mood", "Person" ]
Age, 18 to 75 years old, male or female, posterior or posterolateral, disc herniations, one level between L1 and S1, radiographic confirmation, neural compression, CT and / or MRI, At least six ( 6 ) weeks, failed, conservative, treatment, prior to surgery, immediate, surgery, prevent, permanent disability, posterior disc height, index level(s ), Lower back pain and / or sciatica, spinal claudication, Oswestry Questionnaire score, at least 40/100, at baseline, VAS leg pain, at least 40/100, at baseline	NCT03366779_inc_task2	Sentence: Age 18 to 75 years old (male or female). Patients with posterior or posterolateral disc herniations at one level between L1 and S1 with radiographic confirmation of neural compression using CT and/or MRI. At least six (6) weeks of failed, conservative treatment prior to surgery, or requires immediate surgery to prevent permanent disability. Minimum posterior disc height of 5mm at the index level(s). Lower back pain and/or sciatica with or without spinal claudication. Oswestry Questionnaire score of at least 40/100 at baseline. VAS leg pain of at least 40/100 at baseline. Psychosocially, mentally and physically able to fully comply with the clinical protocol and willing to adhere to follow-up schedule and requirements. Instructions: please extract entity words from the input sentence	[ "B-Person", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "B-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "B-Condition", "I-Condition", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "B-Qualifier", "I-Qualifier", "O", "B-Condition", "I-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "B-Multiplier", "I-Multiplier", "I-Multiplier", "I-Multiplier", "I-Multiplier", "I-Multiplier", "I-Multiplier", "O", "B-Qualifier", "O", "B-Qualifier", "B-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "B-Qualifier", "B-Procedure", "O", "B-Mood", "B-Condition", "I-Condition", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "O", "O", "O", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "I-Value", "B-Temporal", "I-Temporal", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "I-Value", "B-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Age 18 to 75 years old (male or female). Patients with posterior or posterolateral disc herniations at one level between L1 and S1 with radiographic confirmation of neural compression using CT and/or MRI. At least six (6) weeks of failed, conservative treatment prior to surgery, or requires immediate surgery to prevent permanent disability. Minimum posterior disc height of 5mm at the index level(s). Lower back pain and/or sciatica with or without spinal claudication. Oswestry Questionnaire score of at least 40/100 at baseline. VAS leg pain of at least 40/100 at baseline. Psychosocially, mentally and physically able to fully comply with the clinical protocol and willing to adhere to follow-up schedule and requirements.	[ "Age", "18", "to", "75", "years", "old", "(", "male", "or", "female", ")", ".", "\n", "Patients", "with", "posterior", "or", "posterolateral", "disc", "herniations", "at", "one", "level", "between", "L1", "and", "S1", "with", "radiographic", "confirmation", "of", "neural", "compression", "using", "CT", "and", "/", "or", "MRI", ".", "\n", "At", "least", "six", "(", "6", ")", "weeks", "of", "failed", ",", "conservative", "treatment", "prior", "to", "surgery", ",", "or", "requires", "immediate", "surgery", "to", "prevent", "permanent", "disability", ".", "\n", "Minimum", "posterior", "disc", "height", "of", "5", "mm", "at", "the", "index", "level(s", ")", ".", "\n", "Lower", "back", "pain", "and", "/", "or", "sciatica", "with", "or", "without", "spinal", "claudication", ".", "\n", "Oswestry", "Questionnaire", "score", "of", "at", "least", "40/100", "at", "baseline", ".", "\n", "VAS", "leg", "pain", "of", "at", "least", "40/100", "at", "baseline", ".", "\n", "Psychosocially", ",", "mentally", "and", "physically", "able", "to", "fully", "comply", "with", "the", "clinical", "protocol", "and", "willing", "to", "adhere", "to", "follow", "-", "up", "schedule", "and", "requirements", ".", "\n" ]	[ "Scope", "Measurement", "Qualifier", "Multiplier", "Condition", "Value", "Temporal", "Procedure", "Mood", "Person" ]
Kopf - Hals - Bereich is an umlsterm, radiologischen is an umlsterm, Diagnostik is an umlsterm, Kopf - Hals - Radiologie is an umlsterm, Persoenlichkeiten is an umlsterm, Geschichte is an umlsterm, Roentgenstrahlen is an umlsterm, Schaedelinnere is an umlsterm, Halsstrukturen is an umlsterm, Spezialprojektionen is an umlsterm, Tomographie is an umlsterm, Computertomographie is an umlsterm, Magnetresonanztomographie is an umlsterm, Arbeit is an umlsterm, Fortbildung is an umlsterm, Kopf is an umlsterm, Hals is an umlsterm	DerRadiologe.60360175.ger.abstr_task0	Sentence: Der Kopf-Hals-Bereich ist im Vergleich zu den anderen Regionen der radiologischen Diagnostik ein begrenztes Gebiet . Trotzdem hat die Kopf-Hals-Radiologie eine lange , interessante und von hervorragenden medizinischen Persoenlichkeiten gepraegte Geschichte . Wenn man beruecksichtigt , dass vor der Entdeckung der Roentgenstrahlen Einblicke in das Schaedelinnere und die Halsstrukturen ohne Sektion oder Operation ueberhaupt nicht moeglich waren , bedeutete bereits die Einfuehrung der Summationsaufnahmen und die Erarbeitung von Spezialprojektionen ein entscheidender Schritt . Ein zweiter diagnostischer Durchbruch erfolgte in den 50er Jahren dieses Jahrhunderts durch die Entwicklung der Schnittbildverfahren . Diese fuehrten zunaechst als konventionelle Tomographie , dann als Computertomographie und Magnetresonanztomographie zu erstaunlichen und unerwarteten Ergebnissen . Im MRT-Bereich ist diese Entwicklung noch nicht abgeschlossen . Intensivere medizinisch-wissenschaftliche Arbeit und gezieltere Fortbildung , auch in europaeischem Rahmen , erscheinen erforderlich , um dieser Entwicklung gerade im Spezialbereich Kopf und Hals gerecht zu werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O" ]	Der Kopf-Hals-Bereich ist im Vergleich zu den anderen Regionen der radiologischen Diagnostik ein begrenztes Gebiet . Trotzdem hat die Kopf-Hals-Radiologie eine lange , interessante und von hervorragenden medizinischen Persoenlichkeiten gepraegte Geschichte . Wenn man beruecksichtigt , dass vor der Entdeckung der Roentgenstrahlen Einblicke in das Schaedelinnere und die Halsstrukturen ohne Sektion oder Operation ueberhaupt nicht moeglich waren , bedeutete bereits die Einfuehrung der Summationsaufnahmen und die Erarbeitung von Spezialprojektionen ein entscheidender Schritt . Ein zweiter diagnostischer Durchbruch erfolgte in den 50er Jahren dieses Jahrhunderts durch die Entwicklung der Schnittbildverfahren . Diese fuehrten zunaechst als konventionelle Tomographie , dann als Computertomographie und Magnetresonanztomographie zu erstaunlichen und unerwarteten Ergebnissen . Im MRT-Bereich ist diese Entwicklung noch nicht abgeschlossen . Intensivere medizinisch-wissenschaftliche Arbeit und gezieltere Fortbildung , auch in europaeischem Rahmen , erscheinen erforderlich , um dieser Entwicklung gerade im Spezialbereich Kopf und Hals gerecht zu werden .	[ "Der", "Kopf", "-", "Hals", "-", "Bereich", "ist", "im", "Vergleich", "zu", "den", "anderen", "Regionen", "der", "radiologischen", "Diagnostik", "ein", "begrenztes", "Gebiet", ".", "Trotzdem", "hat", "die", "Kopf", "-", "Hals", "-", "Radiologie", "eine", "lange", ",", "interessante", "und", "von", "hervorragenden", "medizinischen", "Persoenlichkeiten", "gepraegte", "Geschichte", ".", "Wenn", "man", "beruecksichtigt", ",", "dass", "vor", "der", "Entdeckung", "der", "Roentgenstrahlen", "Einblicke", "in", "das", "Schaedelinnere", "und", "die", "Halsstrukturen", "ohne", "Sektion", "oder", "Operation", "ueberhaupt", "nicht", "moeglich", "waren", ",", "bedeutete", "bereits", "die", "Einfuehrung", "der", "Summationsaufnahmen", "und", "die", "Erarbeitung", "von", "Spezialprojektionen", "ein", "entscheidender", "Schritt", ".", "Ein", "zweiter", "diagnostischer", "Durchbruch", "erfolgte", "in", "den", "50er", "Jahren", "dieses", "Jahrhunderts", "durch", "die", "Entwicklung", "der", "Schnittbildverfahren", ".", "Diese", "fuehrten", "zunaechst", "als", "konventionelle", "Tomographie", ",", "dann", "als", "Computertomographie", "und", "Magnetresonanztomographie", "zu", "erstaunlichen", "und", "unerwarteten", "Ergebnissen", ".", "Im", "MRT", "-", "Bereich", "ist", "diese", "Entwicklung", "noch", "nicht", "abgeschlossen", ".", "Intensivere", "medizinisch", "-", "wissenschaftliche", "Arbeit", "und", "gezieltere", "Fortbildung", ",", "auch", "in", "europaeischem", "Rahmen", ",", "erscheinen", "erforderlich", ",", "um", "dieser", "Entwicklung", "gerade", "im", "Spezialbereich", "Kopf", "und", "Hals", "gerecht", "zu", "werden", "." ]	[ "umlsterm" ]
Kopf - Hals - Bereich is an umlsterm, radiologischen is an umlsterm, Diagnostik is an umlsterm, Kopf - Hals - Radiologie is an umlsterm, Persoenlichkeiten is an umlsterm, Geschichte is an umlsterm, Roentgenstrahlen is an umlsterm, Schaedelinnere is an umlsterm, Halsstrukturen is an umlsterm, Spezialprojektionen is an umlsterm, Tomographie is an umlsterm, Computertomographie is an umlsterm, Magnetresonanztomographie is an umlsterm, Arbeit is an umlsterm, Fortbildung is an umlsterm, Kopf is an umlsterm, Hals is an umlsterm	DerRadiologe.60360175.ger.abstr_task1	Sentence: Der Kopf-Hals-Bereich ist im Vergleich zu den anderen Regionen der radiologischen Diagnostik ein begrenztes Gebiet . Trotzdem hat die Kopf-Hals-Radiologie eine lange , interessante und von hervorragenden medizinischen Persoenlichkeiten gepraegte Geschichte . Wenn man beruecksichtigt , dass vor der Entdeckung der Roentgenstrahlen Einblicke in das Schaedelinnere und die Halsstrukturen ohne Sektion oder Operation ueberhaupt nicht moeglich waren , bedeutete bereits die Einfuehrung der Summationsaufnahmen und die Erarbeitung von Spezialprojektionen ein entscheidender Schritt . Ein zweiter diagnostischer Durchbruch erfolgte in den 50er Jahren dieses Jahrhunderts durch die Entwicklung der Schnittbildverfahren . Diese fuehrten zunaechst als konventionelle Tomographie , dann als Computertomographie und Magnetresonanztomographie zu erstaunlichen und unerwarteten Ergebnissen . Im MRT-Bereich ist diese Entwicklung noch nicht abgeschlossen . Intensivere medizinisch-wissenschaftliche Arbeit und gezieltere Fortbildung , auch in europaeischem Rahmen , erscheinen erforderlich , um dieser Entwicklung gerade im Spezialbereich Kopf und Hals gerecht zu werden . Instructions: please typing these entity words according to sentence: Kopf - Hals - Bereich, radiologischen, Diagnostik, Kopf - Hals - Radiologie, Persoenlichkeiten, Geschichte, Roentgenstrahlen, Schaedelinnere, Halsstrukturen, Spezialprojektionen, Tomographie, Computertomographie, Magnetresonanztomographie, Arbeit, Fortbildung, Kopf, Hals Options: umlsterm	[ "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O" ]	Der Kopf-Hals-Bereich ist im Vergleich zu den anderen Regionen der radiologischen Diagnostik ein begrenztes Gebiet . Trotzdem hat die Kopf-Hals-Radiologie eine lange , interessante und von hervorragenden medizinischen Persoenlichkeiten gepraegte Geschichte . Wenn man beruecksichtigt , dass vor der Entdeckung der Roentgenstrahlen Einblicke in das Schaedelinnere und die Halsstrukturen ohne Sektion oder Operation ueberhaupt nicht moeglich waren , bedeutete bereits die Einfuehrung der Summationsaufnahmen und die Erarbeitung von Spezialprojektionen ein entscheidender Schritt . Ein zweiter diagnostischer Durchbruch erfolgte in den 50er Jahren dieses Jahrhunderts durch die Entwicklung der Schnittbildverfahren . Diese fuehrten zunaechst als konventionelle Tomographie , dann als Computertomographie und Magnetresonanztomographie zu erstaunlichen und unerwarteten Ergebnissen . Im MRT-Bereich ist diese Entwicklung noch nicht abgeschlossen . Intensivere medizinisch-wissenschaftliche Arbeit und gezieltere Fortbildung , auch in europaeischem Rahmen , erscheinen erforderlich , um dieser Entwicklung gerade im Spezialbereich Kopf und Hals gerecht zu werden .	[ "Der", "Kopf", "-", "Hals", "-", "Bereich", "ist", "im", "Vergleich", "zu", "den", "anderen", "Regionen", "der", "radiologischen", "Diagnostik", "ein", "begrenztes", "Gebiet", ".", "Trotzdem", "hat", "die", "Kopf", "-", "Hals", "-", "Radiologie", "eine", "lange", ",", "interessante", "und", "von", "hervorragenden", "medizinischen", "Persoenlichkeiten", "gepraegte", "Geschichte", ".", "Wenn", "man", "beruecksichtigt", ",", "dass", "vor", "der", "Entdeckung", "der", "Roentgenstrahlen", "Einblicke", "in", "das", "Schaedelinnere", "und", "die", "Halsstrukturen", "ohne", "Sektion", "oder", "Operation", "ueberhaupt", "nicht", "moeglich", "waren", ",", "bedeutete", "bereits", "die", "Einfuehrung", "der", "Summationsaufnahmen", "und", "die", "Erarbeitung", "von", "Spezialprojektionen", "ein", "entscheidender", "Schritt", ".", "Ein", "zweiter", "diagnostischer", "Durchbruch", "erfolgte", "in", "den", "50er", "Jahren", "dieses", "Jahrhunderts", "durch", "die", "Entwicklung", "der", "Schnittbildverfahren", ".", "Diese", "fuehrten", "zunaechst", "als", "konventionelle", "Tomographie", ",", "dann", "als", "Computertomographie", "und", "Magnetresonanztomographie", "zu", "erstaunlichen", "und", "unerwarteten", "Ergebnissen", ".", "Im", "MRT", "-", "Bereich", "ist", "diese", "Entwicklung", "noch", "nicht", "abgeschlossen", ".", "Intensivere", "medizinisch", "-", "wissenschaftliche", "Arbeit", "und", "gezieltere", "Fortbildung", ",", "auch", "in", "europaeischem", "Rahmen", ",", "erscheinen", "erforderlich", ",", "um", "dieser", "Entwicklung", "gerade", "im", "Spezialbereich", "Kopf", "und", "Hals", "gerecht", "zu", "werden", "." ]	[ "umlsterm" ]
Kopf - Hals - Bereich, radiologischen, Diagnostik, Kopf - Hals - Radiologie, Persoenlichkeiten, Geschichte, Roentgenstrahlen, Schaedelinnere, Halsstrukturen, Spezialprojektionen, Tomographie, Computertomographie, Magnetresonanztomographie, Arbeit, Fortbildung, Kopf, Hals	DerRadiologe.60360175.ger.abstr_task2	Sentence: Der Kopf-Hals-Bereich ist im Vergleich zu den anderen Regionen der radiologischen Diagnostik ein begrenztes Gebiet . Trotzdem hat die Kopf-Hals-Radiologie eine lange , interessante und von hervorragenden medizinischen Persoenlichkeiten gepraegte Geschichte . Wenn man beruecksichtigt , dass vor der Entdeckung der Roentgenstrahlen Einblicke in das Schaedelinnere und die Halsstrukturen ohne Sektion oder Operation ueberhaupt nicht moeglich waren , bedeutete bereits die Einfuehrung der Summationsaufnahmen und die Erarbeitung von Spezialprojektionen ein entscheidender Schritt . Ein zweiter diagnostischer Durchbruch erfolgte in den 50er Jahren dieses Jahrhunderts durch die Entwicklung der Schnittbildverfahren . Diese fuehrten zunaechst als konventionelle Tomographie , dann als Computertomographie und Magnetresonanztomographie zu erstaunlichen und unerwarteten Ergebnissen . Im MRT-Bereich ist diese Entwicklung noch nicht abgeschlossen . Intensivere medizinisch-wissenschaftliche Arbeit und gezieltere Fortbildung , auch in europaeischem Rahmen , erscheinen erforderlich , um dieser Entwicklung gerade im Spezialbereich Kopf und Hals gerecht zu werden . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O" ]	Der Kopf-Hals-Bereich ist im Vergleich zu den anderen Regionen der radiologischen Diagnostik ein begrenztes Gebiet . Trotzdem hat die Kopf-Hals-Radiologie eine lange , interessante und von hervorragenden medizinischen Persoenlichkeiten gepraegte Geschichte . Wenn man beruecksichtigt , dass vor der Entdeckung der Roentgenstrahlen Einblicke in das Schaedelinnere und die Halsstrukturen ohne Sektion oder Operation ueberhaupt nicht moeglich waren , bedeutete bereits die Einfuehrung der Summationsaufnahmen und die Erarbeitung von Spezialprojektionen ein entscheidender Schritt . Ein zweiter diagnostischer Durchbruch erfolgte in den 50er Jahren dieses Jahrhunderts durch die Entwicklung der Schnittbildverfahren . Diese fuehrten zunaechst als konventionelle Tomographie , dann als Computertomographie und Magnetresonanztomographie zu erstaunlichen und unerwarteten Ergebnissen . Im MRT-Bereich ist diese Entwicklung noch nicht abgeschlossen . Intensivere medizinisch-wissenschaftliche Arbeit und gezieltere Fortbildung , auch in europaeischem Rahmen , erscheinen erforderlich , um dieser Entwicklung gerade im Spezialbereich Kopf und Hals gerecht zu werden .	[ "Der", "Kopf", "-", "Hals", "-", "Bereich", "ist", "im", "Vergleich", "zu", "den", "anderen", "Regionen", "der", "radiologischen", "Diagnostik", "ein", "begrenztes", "Gebiet", ".", "Trotzdem", "hat", "die", "Kopf", "-", "Hals", "-", "Radiologie", "eine", "lange", ",", "interessante", "und", "von", "hervorragenden", "medizinischen", "Persoenlichkeiten", "gepraegte", "Geschichte", ".", "Wenn", "man", "beruecksichtigt", ",", "dass", "vor", "der", "Entdeckung", "der", "Roentgenstrahlen", "Einblicke", "in", "das", "Schaedelinnere", "und", "die", "Halsstrukturen", "ohne", "Sektion", "oder", "Operation", "ueberhaupt", "nicht", "moeglich", "waren", ",", "bedeutete", "bereits", "die", "Einfuehrung", "der", "Summationsaufnahmen", "und", "die", "Erarbeitung", "von", "Spezialprojektionen", "ein", "entscheidender", "Schritt", ".", "Ein", "zweiter", "diagnostischer", "Durchbruch", "erfolgte", "in", "den", "50er", "Jahren", "dieses", "Jahrhunderts", "durch", "die", "Entwicklung", "der", "Schnittbildverfahren", ".", "Diese", "fuehrten", "zunaechst", "als", "konventionelle", "Tomographie", ",", "dann", "als", "Computertomographie", "und", "Magnetresonanztomographie", "zu", "erstaunlichen", "und", "unerwarteten", "Ergebnissen", ".", "Im", "MRT", "-", "Bereich", "ist", "diese", "Entwicklung", "noch", "nicht", "abgeschlossen", ".", "Intensivere", "medizinisch", "-", "wissenschaftliche", "Arbeit", "und", "gezieltere", "Fortbildung", ",", "auch", "in", "europaeischem", "Rahmen", ",", "erscheinen", "erforderlich", ",", "um", "dieser", "Entwicklung", "gerade", "im", "Spezialbereich", "Kopf", "und", "Hals", "gerecht", "zu", "werden", "." ]	[ "umlsterm" ]
CONSTANS is a Protein, COP1 is a Protein, FLOWERING LOCUS T is a Protein, FT is a Protein, CONSTANS is a Protein, CO is a Protein, FT is a Protein, CO is a Protein, CO is a Protein, COP1 is a Protein, COP1 is a Protein, CO is a Protein, CO is a Protein, CO is a Protein, COP1 is a Protein, ubiquitin is a Protein, CO is a Protein, COP1 is a Protein, CO is a Protein, FT is a Protein	305_task0	Sentence: COP1-mediated ubiquitination of CONSTANS is implicated in cryptochrome regulation of flowering in Arabidopsis. In Arabidopsis thaliana, the blue light photoreceptor cryptochromes (CRY) act to promote photomorphogenic development and the transition from vegetative to floral development in long days (LDs). We previously proposed that one of the mechanisms by which CRY regulates light responses is via its physical interaction with COP1, a RING motif-containing E3 ligase. Under LDs, the transcription of FLOWERING LOCUS T (FT) is activated by CONSTANS (CO) in leaf, and the FT protein moves to the shoot apex to induce flowering. CO protein is degraded in darkness, whereas it is stabilized by the CRY-mediated signal. However, the mechanism underlying this process is unknown. We show in this report that CO acts genetically downstream of COP1 and CRY to regulate flowering time. In addition, COP1 physically interacts with CO and functions as an E3 ligase, ubiquitinating CO in vitro and reducing CO levels in vivo. These results suggest that COP1 acts as a repressor of flowering by promoting the ubiquitin-mediated proteolysis of CO in darkness and that CRY-mediated signal may negatively regulate COP1, thereby stabilizing CO, activating FT transcription, and inducing flowering. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein	[ "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O" ]	COP1-mediated ubiquitination of CONSTANS is implicated in cryptochrome regulation of flowering in Arabidopsis. In Arabidopsis thaliana, the blue light photoreceptor cryptochromes (CRY) act to promote photomorphogenic development and the transition from vegetative to floral development in long days (LDs). We previously proposed that one of the mechanisms by which CRY regulates light responses is via its physical interaction with COP1, a RING motif-containing E3 ligase. Under LDs, the transcription of FLOWERING LOCUS T (FT) is activated by CONSTANS (CO) in leaf, and the FT protein moves to the shoot apex to induce flowering. CO protein is degraded in darkness, whereas it is stabilized by the CRY-mediated signal. However, the mechanism underlying this process is unknown. We show in this report that CO acts genetically downstream of COP1 and CRY to regulate flowering time. In addition, COP1 physically interacts with CO and functions as an E3 ligase, ubiquitinating CO in vitro and reducing CO levels in vivo. These results suggest that COP1 acts as a repressor of flowering by promoting the ubiquitin-mediated proteolysis of CO in darkness and that CRY-mediated signal may negatively regulate COP1, thereby stabilizing CO, activating FT transcription, and inducing flowering.	[ "COP1-mediated", "ubiquitination", "of", "CONSTANS", "is", "implicated", "in", "cryptochrome", "regulation", "of", "flowering", "in", "Arabidopsis", ".", "\n", "In", "Arabidopsis", "thaliana", ",", "the", "blue", "light", "photoreceptor", "cryptochromes", "(", "CRY", ")", "act", "to", "promote", "photomorphogenic", "development", "and", "the", "transition", "from", "vegetative", "to", "floral", "development", "in", "long", "days", "(", "LDs", ")", ".", "We", "previously", "proposed", "that", "one", "of", "the", "mechanisms", "by", "which", "CRY", "regulates", "light", "responses", "is", "via", "its", "physical", "interaction", "with", "COP1", ",", "a", "RING", "motif", "-", "containing", "E3", "ligase", ".", "Under", "LDs", ",", "the", "transcription", "of", "FLOWERING", "LOCUS", "T", "(", "FT", ")", "is", "activated", "by", "CONSTANS", "(", "CO", ")", "in", "leaf", ",", "and", "the", "FT", "protein", "moves", "to", "the", "shoot", "apex", "to", "induce", "flowering", ".", "CO", "protein", "is", "degraded", "in", "darkness", ",", "whereas", "it", "is", "stabilized", "by", "the", "CRY", "-", "mediated", "signal", ".", "However", ",", "the", "mechanism", "underlying", "this", "process", "is", "unknown", ".", "We", "show", "in", "this", "report", "that", "CO", "acts", "genetically", "downstream", "of", "COP1", "and", "CRY", "to", "regulate", "flowering", "time", ".", "In", "addition", ",", "COP1", "physically", "interacts", "with", "CO", "and", "functions", "as", "an", "E3", "ligase", ",", "ubiquitinating", "CO", "in", "vitro", "and", "reducing", "CO", "levels", "in", "vivo", ".", "These", "results", "suggest", "that", "COP1", "acts", "as", "a", "repressor", "of", "flowering", "by", "promoting", "the", "ubiquitin", "-", "mediated", "proteolysis", "of", "CO", "in", "darkness", "and", "that", "CRY", "-", "mediated", "signal", "may", "negatively", "regulate", "COP1", ",", "thereby", "stabilizing", "CO", ",", "activating", "FT", "transcription", ",", "and", "inducing", "flowering", ".", "\n" ]	[ "Protein" ]
CONSTANS is a Protein, COP1 is a Protein, FLOWERING LOCUS T is a Protein, FT is a Protein, CONSTANS is a Protein, CO is a Protein, FT is a Protein, CO is a Protein, CO is a Protein, COP1 is a Protein, COP1 is a Protein, CO is a Protein, CO is a Protein, CO is a Protein, COP1 is a Protein, ubiquitin is a Protein, CO is a Protein, COP1 is a Protein, CO is a Protein, FT is a Protein	305_task1	Sentence: COP1-mediated ubiquitination of CONSTANS is implicated in cryptochrome regulation of flowering in Arabidopsis. In Arabidopsis thaliana, the blue light photoreceptor cryptochromes (CRY) act to promote photomorphogenic development and the transition from vegetative to floral development in long days (LDs). We previously proposed that one of the mechanisms by which CRY regulates light responses is via its physical interaction with COP1, a RING motif-containing E3 ligase. Under LDs, the transcription of FLOWERING LOCUS T (FT) is activated by CONSTANS (CO) in leaf, and the FT protein moves to the shoot apex to induce flowering. CO protein is degraded in darkness, whereas it is stabilized by the CRY-mediated signal. However, the mechanism underlying this process is unknown. We show in this report that CO acts genetically downstream of COP1 and CRY to regulate flowering time. In addition, COP1 physically interacts with CO and functions as an E3 ligase, ubiquitinating CO in vitro and reducing CO levels in vivo. These results suggest that COP1 acts as a repressor of flowering by promoting the ubiquitin-mediated proteolysis of CO in darkness and that CRY-mediated signal may negatively regulate COP1, thereby stabilizing CO, activating FT transcription, and inducing flowering. Instructions: please typing these entity words according to sentence: CONSTANS, COP1, FLOWERING LOCUS T, FT, CONSTANS, CO, FT, CO, CO, COP1, COP1, CO, CO, CO, COP1, ubiquitin, CO, COP1, CO, FT Options: Protein	[ "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O" ]	COP1-mediated ubiquitination of CONSTANS is implicated in cryptochrome regulation of flowering in Arabidopsis. In Arabidopsis thaliana, the blue light photoreceptor cryptochromes (CRY) act to promote photomorphogenic development and the transition from vegetative to floral development in long days (LDs). We previously proposed that one of the mechanisms by which CRY regulates light responses is via its physical interaction with COP1, a RING motif-containing E3 ligase. Under LDs, the transcription of FLOWERING LOCUS T (FT) is activated by CONSTANS (CO) in leaf, and the FT protein moves to the shoot apex to induce flowering. CO protein is degraded in darkness, whereas it is stabilized by the CRY-mediated signal. However, the mechanism underlying this process is unknown. We show in this report that CO acts genetically downstream of COP1 and CRY to regulate flowering time. In addition, COP1 physically interacts with CO and functions as an E3 ligase, ubiquitinating CO in vitro and reducing CO levels in vivo. These results suggest that COP1 acts as a repressor of flowering by promoting the ubiquitin-mediated proteolysis of CO in darkness and that CRY-mediated signal may negatively regulate COP1, thereby stabilizing CO, activating FT transcription, and inducing flowering.	[ "COP1-mediated", "ubiquitination", "of", "CONSTANS", "is", "implicated", "in", "cryptochrome", "regulation", "of", "flowering", "in", "Arabidopsis", ".", "\n", "In", "Arabidopsis", "thaliana", ",", "the", "blue", "light", "photoreceptor", "cryptochromes", "(", "CRY", ")", "act", "to", "promote", "photomorphogenic", "development", "and", "the", "transition", "from", "vegetative", "to", "floral", "development", "in", "long", "days", "(", "LDs", ")", ".", "We", "previously", "proposed", "that", "one", "of", "the", "mechanisms", "by", "which", "CRY", "regulates", "light", "responses", "is", "via", "its", "physical", "interaction", "with", "COP1", ",", "a", "RING", "motif", "-", "containing", "E3", "ligase", ".", "Under", "LDs", ",", "the", "transcription", "of", "FLOWERING", "LOCUS", "T", "(", "FT", ")", "is", "activated", "by", "CONSTANS", "(", "CO", ")", "in", "leaf", ",", "and", "the", "FT", "protein", "moves", "to", "the", "shoot", "apex", "to", "induce", "flowering", ".", "CO", "protein", "is", "degraded", "in", "darkness", ",", "whereas", "it", "is", "stabilized", "by", "the", "CRY", "-", "mediated", "signal", ".", "However", ",", "the", "mechanism", "underlying", "this", "process", "is", "unknown", ".", "We", "show", "in", "this", "report", "that", "CO", "acts", "genetically", "downstream", "of", "COP1", "and", "CRY", "to", "regulate", "flowering", "time", ".", "In", "addition", ",", "COP1", "physically", "interacts", "with", "CO", "and", "functions", "as", "an", "E3", "ligase", ",", "ubiquitinating", "CO", "in", "vitro", "and", "reducing", "CO", "levels", "in", "vivo", ".", "These", "results", "suggest", "that", "COP1", "acts", "as", "a", "repressor", "of", "flowering", "by", "promoting", "the", "ubiquitin", "-", "mediated", "proteolysis", "of", "CO", "in", "darkness", "and", "that", "CRY", "-", "mediated", "signal", "may", "negatively", "regulate", "COP1", ",", "thereby", "stabilizing", "CO", ",", "activating", "FT", "transcription", ",", "and", "inducing", "flowering", ".", "\n" ]	[ "Protein" ]
CONSTANS, COP1, FLOWERING LOCUS T, FT, CONSTANS, CO, FT, CO, CO, COP1, COP1, CO, CO, CO, COP1, ubiquitin, CO, COP1, CO, FT	305_task2	Sentence: COP1-mediated ubiquitination of CONSTANS is implicated in cryptochrome regulation of flowering in Arabidopsis. In Arabidopsis thaliana, the blue light photoreceptor cryptochromes (CRY) act to promote photomorphogenic development and the transition from vegetative to floral development in long days (LDs). We previously proposed that one of the mechanisms by which CRY regulates light responses is via its physical interaction with COP1, a RING motif-containing E3 ligase. Under LDs, the transcription of FLOWERING LOCUS T (FT) is activated by CONSTANS (CO) in leaf, and the FT protein moves to the shoot apex to induce flowering. CO protein is degraded in darkness, whereas it is stabilized by the CRY-mediated signal. However, the mechanism underlying this process is unknown. We show in this report that CO acts genetically downstream of COP1 and CRY to regulate flowering time. In addition, COP1 physically interacts with CO and functions as an E3 ligase, ubiquitinating CO in vitro and reducing CO levels in vivo. These results suggest that COP1 acts as a repressor of flowering by promoting the ubiquitin-mediated proteolysis of CO in darkness and that CRY-mediated signal may negatively regulate COP1, thereby stabilizing CO, activating FT transcription, and inducing flowering. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O" ]	COP1-mediated ubiquitination of CONSTANS is implicated in cryptochrome regulation of flowering in Arabidopsis. In Arabidopsis thaliana, the blue light photoreceptor cryptochromes (CRY) act to promote photomorphogenic development and the transition from vegetative to floral development in long days (LDs). We previously proposed that one of the mechanisms by which CRY regulates light responses is via its physical interaction with COP1, a RING motif-containing E3 ligase. Under LDs, the transcription of FLOWERING LOCUS T (FT) is activated by CONSTANS (CO) in leaf, and the FT protein moves to the shoot apex to induce flowering. CO protein is degraded in darkness, whereas it is stabilized by the CRY-mediated signal. However, the mechanism underlying this process is unknown. We show in this report that CO acts genetically downstream of COP1 and CRY to regulate flowering time. In addition, COP1 physically interacts with CO and functions as an E3 ligase, ubiquitinating CO in vitro and reducing CO levels in vivo. These results suggest that COP1 acts as a repressor of flowering by promoting the ubiquitin-mediated proteolysis of CO in darkness and that CRY-mediated signal may negatively regulate COP1, thereby stabilizing CO, activating FT transcription, and inducing flowering.	[ "COP1-mediated", "ubiquitination", "of", "CONSTANS", "is", "implicated", "in", "cryptochrome", "regulation", "of", "flowering", "in", "Arabidopsis", ".", "\n", "In", "Arabidopsis", "thaliana", ",", "the", "blue", "light", "photoreceptor", "cryptochromes", "(", "CRY", ")", "act", "to", "promote", "photomorphogenic", "development", "and", "the", "transition", "from", "vegetative", "to", "floral", "development", "in", "long", "days", "(", "LDs", ")", ".", "We", "previously", "proposed", "that", "one", "of", "the", "mechanisms", "by", "which", "CRY", "regulates", "light", "responses", "is", "via", "its", "physical", "interaction", "with", "COP1", ",", "a", "RING", "motif", "-", "containing", "E3", "ligase", ".", "Under", "LDs", ",", "the", "transcription", "of", "FLOWERING", "LOCUS", "T", "(", "FT", ")", "is", "activated", "by", "CONSTANS", "(", "CO", ")", "in", "leaf", ",", "and", "the", "FT", "protein", "moves", "to", "the", "shoot", "apex", "to", "induce", "flowering", ".", "CO", "protein", "is", "degraded", "in", "darkness", ",", "whereas", "it", "is", "stabilized", "by", "the", "CRY", "-", "mediated", "signal", ".", "However", ",", "the", "mechanism", "underlying", "this", "process", "is", "unknown", ".", "We", "show", "in", "this", "report", "that", "CO", "acts", "genetically", "downstream", "of", "COP1", "and", "CRY", "to", "regulate", "flowering", "time", ".", "In", "addition", ",", "COP1", "physically", "interacts", "with", "CO", "and", "functions", "as", "an", "E3", "ligase", ",", "ubiquitinating", "CO", "in", "vitro", "and", "reducing", "CO", "levels", "in", "vivo", ".", "These", "results", "suggest", "that", "COP1", "acts", "as", "a", "repressor", "of", "flowering", "by", "promoting", "the", "ubiquitin", "-", "mediated", "proteolysis", "of", "CO", "in", "darkness", "and", "that", "CRY", "-", "mediated", "signal", "may", "negatively", "regulate", "COP1", ",", "thereby", "stabilizing", "CO", ",", "activating", "FT", "transcription", ",", "and", "inducing", "flowering", ".", "\n" ]	[ "Protein" ]
low - fat , high - fiber diet is a Intervention_Physical, recurrence of colorectal adenomas is a Outcome_Physical, development of recurrent colorectal adenomas is a Outcome_Physical, 2079 is a Participant_Sample-size, women is a Participant_Sex, 35 is a Participant_Age, diet that was low in fat is a Intervention_Educational, high in fiber ( 18 g of dietary fiber per 1000 kcal ) is a Intervention_Educational, fruits and vegetables is a Intervention_Educational, 1905 is a Participant_Sample-size, one recurrent adenoma is a Outcome_Physical, unadjusted risk ratio is a Outcome_Physical, number of such lesions is a Outcome_Physical, recurrence of large adenomas is a Outcome_Physical, advanced adenomas is a Outcome_Physical, risk of recurrence is a Outcome_Physical	3452_task0	Sentence: Lack of effect of a low-fat , high-fiber diet on the recurrence of colorectal adenomas . Polyp Prevention Trial Study Group . BACKGROUND We tested the hypothesis that dietary intervention can inhibit the development of recurrent colorectal adenomas , which are precursors of most large-bowel cancers . METHODS We randomly assigned 2079 men and women who were 35 years of age or older and who had had one or more histologically confirmed colorectal adenomas removed within six months before randomization to one of two groups : an intervention group given intensive counseling and assigned to follow a diet that was low in fat ( 20 percent of total calories ) and high in fiber ( 18 g of dietary fiber per 1000 kcal ) and fruits and vegetables ( 3.5 servings per 1000 kcal ) , and a control group given a standard brochure on healthy eating and assigned to follow their usual diet . Subjects entered the study after undergoing complete colonoscopy and removal of adenomatous polyps ; they remained in the study for approximately four years , undergoing colonoscopy one and four years after randomization . RESULTS A total of 1905 of the randomized subjects ( 91.6 percent ) completed the study . Of the 958 subjects in the intervention group and the 947 in the control group who completed the study , 39.7 percent and 39.5 percent , respectively , had at least one recurrent adenoma ; the unadjusted risk ratio was 1.00 ( 95 percent confidence interval , 0.90 to 1.12 ) . Among subjects with recurrent adenomas , the mean ( +/-SE ) number of such lesions was 1.85+/-0.08 in the intervention group and 1.84+/-0.07 in the control group . The rate of recurrence of large adenomas ( with a maximal diameter of at least 1 cm ) and advanced adenomas ( defined as lesions that had a maximal diameter of at least 1 cm or at least 25 percent villous elements or evidence of high-grade dysplasia , including carcinoma ) did not differ significantly between the two groups . CONCLUSIONS Adopting a diet that is low in fat and high in fiber , fruits , and vegetables does not influence the risk of recurrence of colorectal adenomas . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Physical, Participant_Sex, Intervention_Educational, Participant_Age, Outcome_Physical, Participant_Sample-size	[ "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "B-Participant_Sex", "O", "O", "B-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O" ]	Lack of effect of a low-fat , high-fiber diet on the recurrence of colorectal adenomas . Polyp Prevention Trial Study Group . BACKGROUND We tested the hypothesis that dietary intervention can inhibit the development of recurrent colorectal adenomas , which are precursors of most large-bowel cancers . METHODS We randomly assigned 2079 men and women who were 35 years of age or older and who had had one or more histologically confirmed colorectal adenomas removed within six months before randomization to one of two groups : an intervention group given intensive counseling and assigned to follow a diet that was low in fat ( 20 percent of total calories ) and high in fiber ( 18 g of dietary fiber per 1000 kcal ) and fruits and vegetables ( 3.5 servings per 1000 kcal ) , and a control group given a standard brochure on healthy eating and assigned to follow their usual diet . Subjects entered the study after undergoing complete colonoscopy and removal of adenomatous polyps ; they remained in the study for approximately four years , undergoing colonoscopy one and four years after randomization . RESULTS A total of 1905 of the randomized subjects ( 91.6 percent ) completed the study . Of the 958 subjects in the intervention group and the 947 in the control group who completed the study , 39.7 percent and 39.5 percent , respectively , had at least one recurrent adenoma ; the unadjusted risk ratio was 1.00 ( 95 percent confidence interval , 0.90 to 1.12 ) . Among subjects with recurrent adenomas , the mean ( +/-SE ) number of such lesions was 1.85+/-0.08 in the intervention group and 1.84+/-0.07 in the control group . The rate of recurrence of large adenomas ( with a maximal diameter of at least 1 cm ) and advanced adenomas ( defined as lesions that had a maximal diameter of at least 1 cm or at least 25 percent villous elements or evidence of high-grade dysplasia , including carcinoma ) did not differ significantly between the two groups . CONCLUSIONS Adopting a diet that is low in fat and high in fiber , fruits , and vegetables does not influence the risk of recurrence of colorectal adenomas .	[ "Lack", "of", "effect", "of", "a", "low", "-", "fat", ",", "high", "-", "fiber", "diet", "on", "the", "recurrence", "of", "colorectal", "adenomas", ".", "Polyp", "Prevention", "Trial", "Study", "Group", ".", "BACKGROUND", "We", "tested", "the", "hypothesis", "that", "dietary", "intervention", "can", "inhibit", "the", "development", "of", "recurrent", "colorectal", "adenomas", ",", "which", "are", "precursors", "of", "most", "large", "-", "bowel", "cancers", ".", "METHODS", "We", "randomly", "assigned", "2079", "men", "and", "women", "who", "were", "35", "years", "of", "age", "or", "older", "and", "who", "had", "had", "one", "or", "more", "histologically", "confirmed", "colorectal", "adenomas", "removed", "within", "six", "months", "before", "randomization", "to", "one", "of", "two", "groups", ":", "an", "intervention", "group", "given", "intensive", "counseling", "and", "assigned", "to", "follow", "a", "diet", "that", "was", "low", "in", "fat", "(", "20", "percent", "of", "total", "calories", ")", "and", "high", "in", "fiber", "(", "18", "g", "of", "dietary", "fiber", "per", "1000", "kcal", ")", "and", "fruits", "and", "vegetables", "(", "3.5", "servings", "per", "1000", "kcal", ")", ",", "and", "a", "control", "group", "given", "a", "standard", "brochure", "on", "healthy", "eating", "and", "assigned", "to", "follow", "their", "usual", "diet", ".", "Subjects", "entered", "the", "study", "after", "undergoing", "complete", "colonoscopy", "and", "removal", "of", "adenomatous", "polyps", ";", "they", "remained", "in", "the", "study", "for", "approximately", "four", "years", ",", "undergoing", "colonoscopy", "one", "and", "four", "years", "after", "randomization", ".", "RESULTS", "A", "total", "of", "1905", "of", "the", "randomized", "subjects", "(", "91.6", "percent", ")", "completed", "the", "study", ".", "Of", "the", "958", "subjects", "in", "the", "intervention", "group", "and", "the", "947", "in", "the", "control", "group", "who", "completed", "the", "study", ",", "39.7", "percent", "and", "39.5", "percent", ",", "respectively", ",", "had", "at", "least", "one", "recurrent", "adenoma", ";", "the", "unadjusted", "risk", "ratio", "was", "1.00", "(", "95", "percent", "confidence", "interval", ",", "0.90", "to", "1.12", ")", ".", "Among", "subjects", "with", "recurrent", "adenomas", ",", "the", "mean", "(", "+", "/-SE", ")", "number", "of", "such", "lesions", "was", "1.85+/-0.08", "in", "the", "intervention", "group", "and", "1.84+/-0.07", "in", "the", "control", "group", ".", "The", "rate", "of", "recurrence", "of", "large", "adenomas", "(", "with", "a", "maximal", "diameter", "of", "at", "least", "1", "cm", ")", "and", "advanced", "adenomas", "(", "defined", "as", "lesions", "that", "had", "a", "maximal", "diameter", "of", "at", "least", "1", "cm", "or", "at", "least", "25", "percent", "villous", "elements", "or", "evidence", "of", "high", "-", "grade", "dysplasia", ",", "including", "carcinoma", ")", "did", "not", "differ", "significantly", "between", "the", "two", "groups", ".", "CONCLUSIONS", "Adopting", "a", "diet", "that", "is", "low", "in", "fat", "and", "high", "in", "fiber", ",", "fruits", ",", "and", "vegetables", "does", "not", "influence", "the", "risk", "of", "recurrence", "of", "colorectal", "adenomas", "." ]	[ "Intervention_Educational", "Outcome_Physical", "Intervention_Physical", "Participant_Condition", "Participant_Sex", "Participant_Sample-size", "Participant_Age" ]
low - fat , high - fiber diet is a Intervention_Physical, recurrence of colorectal adenomas is a Outcome_Physical, development of recurrent colorectal adenomas is a Outcome_Physical, 2079 is a Participant_Sample-size, women is a Participant_Sex, 35 is a Participant_Age, diet that was low in fat is a Intervention_Educational, high in fiber ( 18 g of dietary fiber per 1000 kcal ) is a Intervention_Educational, fruits and vegetables is a Intervention_Educational, 1905 is a Participant_Sample-size, one recurrent adenoma is a Outcome_Physical, unadjusted risk ratio is a Outcome_Physical, number of such lesions is a Outcome_Physical, recurrence of large adenomas is a Outcome_Physical, advanced adenomas is a Outcome_Physical, risk of recurrence is a Outcome_Physical	3452_task1	Sentence: Lack of effect of a low-fat , high-fiber diet on the recurrence of colorectal adenomas . Polyp Prevention Trial Study Group . BACKGROUND We tested the hypothesis that dietary intervention can inhibit the development of recurrent colorectal adenomas , which are precursors of most large-bowel cancers . METHODS We randomly assigned 2079 men and women who were 35 years of age or older and who had had one or more histologically confirmed colorectal adenomas removed within six months before randomization to one of two groups : an intervention group given intensive counseling and assigned to follow a diet that was low in fat ( 20 percent of total calories ) and high in fiber ( 18 g of dietary fiber per 1000 kcal ) and fruits and vegetables ( 3.5 servings per 1000 kcal ) , and a control group given a standard brochure on healthy eating and assigned to follow their usual diet . Subjects entered the study after undergoing complete colonoscopy and removal of adenomatous polyps ; they remained in the study for approximately four years , undergoing colonoscopy one and four years after randomization . RESULTS A total of 1905 of the randomized subjects ( 91.6 percent ) completed the study . Of the 958 subjects in the intervention group and the 947 in the control group who completed the study , 39.7 percent and 39.5 percent , respectively , had at least one recurrent adenoma ; the unadjusted risk ratio was 1.00 ( 95 percent confidence interval , 0.90 to 1.12 ) . Among subjects with recurrent adenomas , the mean ( +/-SE ) number of such lesions was 1.85+/-0.08 in the intervention group and 1.84+/-0.07 in the control group . The rate of recurrence of large adenomas ( with a maximal diameter of at least 1 cm ) and advanced adenomas ( defined as lesions that had a maximal diameter of at least 1 cm or at least 25 percent villous elements or evidence of high-grade dysplasia , including carcinoma ) did not differ significantly between the two groups . CONCLUSIONS Adopting a diet that is low in fat and high in fiber , fruits , and vegetables does not influence the risk of recurrence of colorectal adenomas . Instructions: please typing these entity words according to sentence: low - fat , high - fiber diet, recurrence of colorectal adenomas, development of recurrent colorectal adenomas, 2079, women, 35, diet that was low in fat, high in fiber ( 18 g of dietary fiber per 1000 kcal ), fruits and vegetables, 1905, one recurrent adenoma, unadjusted risk ratio, number of such lesions, recurrence of large adenomas, advanced adenomas, risk of recurrence Options: Intervention_Physical, Participant_Sex, Intervention_Educational, Participant_Age, Outcome_Physical, Participant_Sample-size	[ "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "B-Participant_Sex", "O", "O", "B-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O" ]	Lack of effect of a low-fat , high-fiber diet on the recurrence of colorectal adenomas . Polyp Prevention Trial Study Group . BACKGROUND We tested the hypothesis that dietary intervention can inhibit the development of recurrent colorectal adenomas , which are precursors of most large-bowel cancers . METHODS We randomly assigned 2079 men and women who were 35 years of age or older and who had had one or more histologically confirmed colorectal adenomas removed within six months before randomization to one of two groups : an intervention group given intensive counseling and assigned to follow a diet that was low in fat ( 20 percent of total calories ) and high in fiber ( 18 g of dietary fiber per 1000 kcal ) and fruits and vegetables ( 3.5 servings per 1000 kcal ) , and a control group given a standard brochure on healthy eating and assigned to follow their usual diet . Subjects entered the study after undergoing complete colonoscopy and removal of adenomatous polyps ; they remained in the study for approximately four years , undergoing colonoscopy one and four years after randomization . RESULTS A total of 1905 of the randomized subjects ( 91.6 percent ) completed the study . Of the 958 subjects in the intervention group and the 947 in the control group who completed the study , 39.7 percent and 39.5 percent , respectively , had at least one recurrent adenoma ; the unadjusted risk ratio was 1.00 ( 95 percent confidence interval , 0.90 to 1.12 ) . Among subjects with recurrent adenomas , the mean ( +/-SE ) number of such lesions was 1.85+/-0.08 in the intervention group and 1.84+/-0.07 in the control group . The rate of recurrence of large adenomas ( with a maximal diameter of at least 1 cm ) and advanced adenomas ( defined as lesions that had a maximal diameter of at least 1 cm or at least 25 percent villous elements or evidence of high-grade dysplasia , including carcinoma ) did not differ significantly between the two groups . CONCLUSIONS Adopting a diet that is low in fat and high in fiber , fruits , and vegetables does not influence the risk of recurrence of colorectal adenomas .	[ "Lack", "of", "effect", "of", "a", "low", "-", "fat", ",", "high", "-", "fiber", "diet", "on", "the", "recurrence", "of", "colorectal", "adenomas", ".", "Polyp", "Prevention", "Trial", "Study", "Group", ".", "BACKGROUND", "We", "tested", "the", "hypothesis", "that", "dietary", "intervention", "can", "inhibit", "the", "development", "of", "recurrent", "colorectal", "adenomas", ",", "which", "are", "precursors", "of", "most", "large", "-", "bowel", "cancers", ".", "METHODS", "We", "randomly", "assigned", "2079", "men", "and", "women", "who", "were", "35", "years", "of", "age", "or", "older", "and", "who", "had", "had", "one", "or", "more", "histologically", "confirmed", "colorectal", "adenomas", "removed", "within", "six", "months", "before", "randomization", "to", "one", "of", "two", "groups", ":", "an", "intervention", "group", "given", "intensive", "counseling", "and", "assigned", "to", "follow", "a", "diet", "that", "was", "low", "in", "fat", "(", "20", "percent", "of", "total", "calories", ")", "and", "high", "in", "fiber", "(", "18", "g", "of", "dietary", "fiber", "per", "1000", "kcal", ")", "and", "fruits", "and", "vegetables", "(", "3.5", "servings", "per", "1000", "kcal", ")", ",", "and", "a", "control", "group", "given", "a", "standard", "brochure", "on", "healthy", "eating", "and", "assigned", "to", "follow", "their", "usual", "diet", ".", "Subjects", "entered", "the", "study", "after", "undergoing", "complete", "colonoscopy", "and", "removal", "of", "adenomatous", "polyps", ";", "they", "remained", "in", "the", "study", "for", "approximately", "four", "years", ",", "undergoing", "colonoscopy", "one", "and", "four", "years", "after", "randomization", ".", "RESULTS", "A", "total", "of", "1905", "of", "the", "randomized", "subjects", "(", "91.6", "percent", ")", "completed", "the", "study", ".", "Of", "the", "958", "subjects", "in", "the", "intervention", "group", "and", "the", "947", "in", "the", "control", "group", "who", "completed", "the", "study", ",", "39.7", "percent", "and", "39.5", "percent", ",", "respectively", ",", "had", "at", "least", "one", "recurrent", "adenoma", ";", "the", "unadjusted", "risk", "ratio", "was", "1.00", "(", "95", "percent", "confidence", "interval", ",", "0.90", "to", "1.12", ")", ".", "Among", "subjects", "with", "recurrent", "adenomas", ",", "the", "mean", "(", "+", "/-SE", ")", "number", "of", "such", "lesions", "was", "1.85+/-0.08", "in", "the", "intervention", "group", "and", "1.84+/-0.07", "in", "the", "control", "group", ".", "The", "rate", "of", "recurrence", "of", "large", "adenomas", "(", "with", "a", "maximal", "diameter", "of", "at", "least", "1", "cm", ")", "and", "advanced", "adenomas", "(", "defined", "as", "lesions", "that", "had", "a", "maximal", "diameter", "of", "at", "least", "1", "cm", "or", "at", "least", "25", "percent", "villous", "elements", "or", "evidence", "of", "high", "-", "grade", "dysplasia", ",", "including", "carcinoma", ")", "did", "not", "differ", "significantly", "between", "the", "two", "groups", ".", "CONCLUSIONS", "Adopting", "a", "diet", "that", "is", "low", "in", "fat", "and", "high", "in", "fiber", ",", "fruits", ",", "and", "vegetables", "does", "not", "influence", "the", "risk", "of", "recurrence", "of", "colorectal", "adenomas", "." ]	[ "Intervention_Educational", "Outcome_Physical", "Intervention_Physical", "Participant_Condition", "Participant_Sex", "Participant_Sample-size", "Participant_Age" ]
low - fat , high - fiber diet, recurrence of colorectal adenomas, development of recurrent colorectal adenomas, 2079, women, 35, diet that was low in fat, high in fiber ( 18 g of dietary fiber per 1000 kcal ), fruits and vegetables, 1905, one recurrent adenoma, unadjusted risk ratio, number of such lesions, recurrence of large adenomas, advanced adenomas, risk of recurrence	3452_task2	Sentence: Lack of effect of a low-fat , high-fiber diet on the recurrence of colorectal adenomas . Polyp Prevention Trial Study Group . BACKGROUND We tested the hypothesis that dietary intervention can inhibit the development of recurrent colorectal adenomas , which are precursors of most large-bowel cancers . METHODS We randomly assigned 2079 men and women who were 35 years of age or older and who had had one or more histologically confirmed colorectal adenomas removed within six months before randomization to one of two groups : an intervention group given intensive counseling and assigned to follow a diet that was low in fat ( 20 percent of total calories ) and high in fiber ( 18 g of dietary fiber per 1000 kcal ) and fruits and vegetables ( 3.5 servings per 1000 kcal ) , and a control group given a standard brochure on healthy eating and assigned to follow their usual diet . Subjects entered the study after undergoing complete colonoscopy and removal of adenomatous polyps ; they remained in the study for approximately four years , undergoing colonoscopy one and four years after randomization . RESULTS A total of 1905 of the randomized subjects ( 91.6 percent ) completed the study . Of the 958 subjects in the intervention group and the 947 in the control group who completed the study , 39.7 percent and 39.5 percent , respectively , had at least one recurrent adenoma ; the unadjusted risk ratio was 1.00 ( 95 percent confidence interval , 0.90 to 1.12 ) . Among subjects with recurrent adenomas , the mean ( +/-SE ) number of such lesions was 1.85+/-0.08 in the intervention group and 1.84+/-0.07 in the control group . The rate of recurrence of large adenomas ( with a maximal diameter of at least 1 cm ) and advanced adenomas ( defined as lesions that had a maximal diameter of at least 1 cm or at least 25 percent villous elements or evidence of high-grade dysplasia , including carcinoma ) did not differ significantly between the two groups . CONCLUSIONS Adopting a diet that is low in fat and high in fiber , fruits , and vegetables does not influence the risk of recurrence of colorectal adenomas . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "B-Participant_Sex", "O", "O", "B-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O" ]	Lack of effect of a low-fat , high-fiber diet on the recurrence of colorectal adenomas . Polyp Prevention Trial Study Group . BACKGROUND We tested the hypothesis that dietary intervention can inhibit the development of recurrent colorectal adenomas , which are precursors of most large-bowel cancers . METHODS We randomly assigned 2079 men and women who were 35 years of age or older and who had had one or more histologically confirmed colorectal adenomas removed within six months before randomization to one of two groups : an intervention group given intensive counseling and assigned to follow a diet that was low in fat ( 20 percent of total calories ) and high in fiber ( 18 g of dietary fiber per 1000 kcal ) and fruits and vegetables ( 3.5 servings per 1000 kcal ) , and a control group given a standard brochure on healthy eating and assigned to follow their usual diet . Subjects entered the study after undergoing complete colonoscopy and removal of adenomatous polyps ; they remained in the study for approximately four years , undergoing colonoscopy one and four years after randomization . RESULTS A total of 1905 of the randomized subjects ( 91.6 percent ) completed the study . Of the 958 subjects in the intervention group and the 947 in the control group who completed the study , 39.7 percent and 39.5 percent , respectively , had at least one recurrent adenoma ; the unadjusted risk ratio was 1.00 ( 95 percent confidence interval , 0.90 to 1.12 ) . Among subjects with recurrent adenomas , the mean ( +/-SE ) number of such lesions was 1.85+/-0.08 in the intervention group and 1.84+/-0.07 in the control group . The rate of recurrence of large adenomas ( with a maximal diameter of at least 1 cm ) and advanced adenomas ( defined as lesions that had a maximal diameter of at least 1 cm or at least 25 percent villous elements or evidence of high-grade dysplasia , including carcinoma ) did not differ significantly between the two groups . CONCLUSIONS Adopting a diet that is low in fat and high in fiber , fruits , and vegetables does not influence the risk of recurrence of colorectal adenomas .	[ "Lack", "of", "effect", "of", "a", "low", "-", "fat", ",", "high", "-", "fiber", "diet", "on", "the", "recurrence", "of", "colorectal", "adenomas", ".", "Polyp", "Prevention", "Trial", "Study", "Group", ".", "BACKGROUND", "We", "tested", "the", "hypothesis", "that", "dietary", "intervention", "can", "inhibit", "the", "development", "of", "recurrent", "colorectal", "adenomas", ",", "which", "are", "precursors", "of", "most", "large", "-", "bowel", "cancers", ".", "METHODS", "We", "randomly", "assigned", "2079", "men", "and", "women", "who", "were", "35", "years", "of", "age", "or", "older", "and", "who", "had", "had", "one", "or", "more", "histologically", "confirmed", "colorectal", "adenomas", "removed", "within", "six", "months", "before", "randomization", "to", "one", "of", "two", "groups", ":", "an", "intervention", "group", "given", "intensive", "counseling", "and", "assigned", "to", "follow", "a", "diet", "that", "was", "low", "in", "fat", "(", "20", "percent", "of", "total", "calories", ")", "and", "high", "in", "fiber", "(", "18", "g", "of", "dietary", "fiber", "per", "1000", "kcal", ")", "and", "fruits", "and", "vegetables", "(", "3.5", "servings", "per", "1000", "kcal", ")", ",", "and", "a", "control", "group", "given", "a", "standard", "brochure", "on", "healthy", "eating", "and", "assigned", "to", "follow", "their", "usual", "diet", ".", "Subjects", "entered", "the", "study", "after", "undergoing", "complete", "colonoscopy", "and", "removal", "of", "adenomatous", "polyps", ";", "they", "remained", "in", "the", "study", "for", "approximately", "four", "years", ",", "undergoing", "colonoscopy", "one", "and", "four", "years", "after", "randomization", ".", "RESULTS", "A", "total", "of", "1905", "of", "the", "randomized", "subjects", "(", "91.6", "percent", ")", "completed", "the", "study", ".", "Of", "the", "958", "subjects", "in", "the", "intervention", "group", "and", "the", "947", "in", "the", "control", "group", "who", "completed", "the", "study", ",", "39.7", "percent", "and", "39.5", "percent", ",", "respectively", ",", "had", "at", "least", "one", "recurrent", "adenoma", ";", "the", "unadjusted", "risk", "ratio", "was", "1.00", "(", "95", "percent", "confidence", "interval", ",", "0.90", "to", "1.12", ")", ".", "Among", "subjects", "with", "recurrent", "adenomas", ",", "the", "mean", "(", "+", "/-SE", ")", "number", "of", "such", "lesions", "was", "1.85+/-0.08", "in", "the", "intervention", "group", "and", "1.84+/-0.07", "in", "the", "control", "group", ".", "The", "rate", "of", "recurrence", "of", "large", "adenomas", "(", "with", "a", "maximal", "diameter", "of", "at", "least", "1", "cm", ")", "and", "advanced", "adenomas", "(", "defined", "as", "lesions", "that", "had", "a", "maximal", "diameter", "of", "at", "least", "1", "cm", "or", "at", "least", "25", "percent", "villous", "elements", "or", "evidence", "of", "high", "-", "grade", "dysplasia", ",", "including", "carcinoma", ")", "did", "not", "differ", "significantly", "between", "the", "two", "groups", ".", "CONCLUSIONS", "Adopting", "a", "diet", "that", "is", "low", "in", "fat", "and", "high", "in", "fiber", ",", "fruits", ",", "and", "vegetables", "does", "not", "influence", "the", "risk", "of", "recurrence", "of", "colorectal", "adenomas", "." ]	[ "Intervention_Educational", "Outcome_Physical", "Intervention_Physical", "Participant_Condition", "Participant_Sex", "Participant_Sample-size", "Participant_Age" ]
Psychiatrie is an umlsterm, Psychotherapie is an umlsterm, Therapieverfahren is an umlsterm, Praxis is an umlsterm, Methode is an umlsterm	DerNervenarzt.00710173.ger.abstr_task0	Sentence: In der Psychiatrie und Psychotherapie finden weiterhin viele Therapieverfahren Anwendung ohne dass ein empirischer Nachweis ihrer Wirksamkeit vorliegt . Die aus dem angloamerikanischen Sprachraum stammende " Evidence-based Medicine " bietet ein Konzept , medizinische Entscheidungen auf der Basis der besten zz . Verfuegbaren externen Evidenz in Verbindung mit der individuellen klinischen Erfahrung zu treffen . In diesem Beitrag werden zunaechst Beispiele einer Non-evidence-based Psychiatry " " aufgezeigt , ein klinisches Beispiel soll das Konzept einer Evidence-based Psychiatry " " vorstellen , am Ende schliesslich steht die Betrachtung ihrer Anwendung , Grenzen und Moeglichkeiten in der Praxis . Zum einen wird der Stellenwert dieser Methode fuer den klinisch taetigen Psychiater und Psychotherapeuten dargestellt . Zum anderen werden moegliche Konsequenzen diskutiert . Diese ergeben sich fuer Aufbereitung und Bereitstellung der Evidenz in Form von Datenbanken und systematischen Uebersichtsarbeiten und in der Notwendigkeit von Umbauprozessen fuer die einzelne Institution wie auch fuer das Gesundheitssystem als Ganzes . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	In der Psychiatrie und Psychotherapie finden weiterhin viele Therapieverfahren Anwendung ohne dass ein empirischer Nachweis ihrer Wirksamkeit vorliegt . Die aus dem angloamerikanischen Sprachraum stammende " Evidence-based Medicine " bietet ein Konzept , medizinische Entscheidungen auf der Basis der besten zz . Verfuegbaren externen Evidenz in Verbindung mit der individuellen klinischen Erfahrung zu treffen . In diesem Beitrag werden zunaechst Beispiele einer Non-evidence-based Psychiatry " " aufgezeigt , ein klinisches Beispiel soll das Konzept einer Evidence-based Psychiatry " " vorstellen , am Ende schliesslich steht die Betrachtung ihrer Anwendung , Grenzen und Moeglichkeiten in der Praxis . Zum einen wird der Stellenwert dieser Methode fuer den klinisch taetigen Psychiater und Psychotherapeuten dargestellt . Zum anderen werden moegliche Konsequenzen diskutiert . Diese ergeben sich fuer Aufbereitung und Bereitstellung der Evidenz in Form von Datenbanken und systematischen Uebersichtsarbeiten und in der Notwendigkeit von Umbauprozessen fuer die einzelne Institution wie auch fuer das Gesundheitssystem als Ganzes .	[ "In", "der", "Psychiatrie", "und", "Psychotherapie", "finden", "weiterhin", "viele", "Therapieverfahren", "Anwendung", "ohne", "dass", "ein", "empirischer", "Nachweis", "ihrer", "Wirksamkeit", "vorliegt", ".", "Die", "aus", "dem", "angloamerikanischen", "Sprachraum", "stammende", "\"", "Evidence", "-", "based", "Medicine", "\"", "bietet", "ein", "Konzept", ",", "medizinische", "Entscheidungen", "auf", "der", "Basis", "der", "besten", "zz", ".", "Verfuegbaren", "externen", "Evidenz", "in", "Verbindung", "mit", "der", "individuellen", "klinischen", "Erfahrung", "zu", "treffen", ".", "In", "diesem", "Beitrag", "werden", "zunaechst", "Beispiele", "einer", "Non", "-", "evidence", "-", "based", "Psychiatry", "\"", "\"", "aufgezeigt", ",", "ein", "klinisches", "Beispiel", "soll", "das", "Konzept", "einer", "Evidence", "-", "based", "Psychiatry", "\"", "\"", "vorstellen", ",", "am", "Ende", "schliesslich", "steht", "die", "Betrachtung", "ihrer", "Anwendung", ",", "Grenzen", "und", "Moeglichkeiten", "in", "der", "Praxis", ".", "Zum", "einen", "wird", "der", "Stellenwert", "dieser", "Methode", "fuer", "den", "klinisch", "taetigen", "Psychiater", "und", "Psychotherapeuten", "dargestellt", ".", "Zum", "anderen", "werden", "moegliche", "Konsequenzen", "diskutiert", ".", "Diese", "ergeben", "sich", "fuer", "Aufbereitung", "und", "Bereitstellung", "der", "Evidenz", "in", "Form", "von", "Datenbanken", "und", "systematischen", "Uebersichtsarbeiten", "und", "in", "der", "Notwendigkeit", "von", "Umbauprozessen", "fuer", "die", "einzelne", "Institution", "wie", "auch", "fuer", "das", "Gesundheitssystem", "als", "Ganzes", "." ]	[ "umlsterm" ]
Psychiatrie is an umlsterm, Psychotherapie is an umlsterm, Therapieverfahren is an umlsterm, Praxis is an umlsterm, Methode is an umlsterm	DerNervenarzt.00710173.ger.abstr_task1	Sentence: In der Psychiatrie und Psychotherapie finden weiterhin viele Therapieverfahren Anwendung ohne dass ein empirischer Nachweis ihrer Wirksamkeit vorliegt . Die aus dem angloamerikanischen Sprachraum stammende " Evidence-based Medicine " bietet ein Konzept , medizinische Entscheidungen auf der Basis der besten zz . Verfuegbaren externen Evidenz in Verbindung mit der individuellen klinischen Erfahrung zu treffen . In diesem Beitrag werden zunaechst Beispiele einer Non-evidence-based Psychiatry " " aufgezeigt , ein klinisches Beispiel soll das Konzept einer Evidence-based Psychiatry " " vorstellen , am Ende schliesslich steht die Betrachtung ihrer Anwendung , Grenzen und Moeglichkeiten in der Praxis . Zum einen wird der Stellenwert dieser Methode fuer den klinisch taetigen Psychiater und Psychotherapeuten dargestellt . Zum anderen werden moegliche Konsequenzen diskutiert . Diese ergeben sich fuer Aufbereitung und Bereitstellung der Evidenz in Form von Datenbanken und systematischen Uebersichtsarbeiten und in der Notwendigkeit von Umbauprozessen fuer die einzelne Institution wie auch fuer das Gesundheitssystem als Ganzes . Instructions: please typing these entity words according to sentence: Psychiatrie, Psychotherapie, Therapieverfahren, Praxis, Methode Options: umlsterm	[ "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	In der Psychiatrie und Psychotherapie finden weiterhin viele Therapieverfahren Anwendung ohne dass ein empirischer Nachweis ihrer Wirksamkeit vorliegt . Die aus dem angloamerikanischen Sprachraum stammende " Evidence-based Medicine " bietet ein Konzept , medizinische Entscheidungen auf der Basis der besten zz . Verfuegbaren externen Evidenz in Verbindung mit der individuellen klinischen Erfahrung zu treffen . In diesem Beitrag werden zunaechst Beispiele einer Non-evidence-based Psychiatry " " aufgezeigt , ein klinisches Beispiel soll das Konzept einer Evidence-based Psychiatry " " vorstellen , am Ende schliesslich steht die Betrachtung ihrer Anwendung , Grenzen und Moeglichkeiten in der Praxis . Zum einen wird der Stellenwert dieser Methode fuer den klinisch taetigen Psychiater und Psychotherapeuten dargestellt . Zum anderen werden moegliche Konsequenzen diskutiert . Diese ergeben sich fuer Aufbereitung und Bereitstellung der Evidenz in Form von Datenbanken und systematischen Uebersichtsarbeiten und in der Notwendigkeit von Umbauprozessen fuer die einzelne Institution wie auch fuer das Gesundheitssystem als Ganzes .	[ "In", "der", "Psychiatrie", "und", "Psychotherapie", "finden", "weiterhin", "viele", "Therapieverfahren", "Anwendung", "ohne", "dass", "ein", "empirischer", "Nachweis", "ihrer", "Wirksamkeit", "vorliegt", ".", "Die", "aus", "dem", "angloamerikanischen", "Sprachraum", "stammende", "\"", "Evidence", "-", "based", "Medicine", "\"", "bietet", "ein", "Konzept", ",", "medizinische", "Entscheidungen", "auf", "der", "Basis", "der", "besten", "zz", ".", "Verfuegbaren", "externen", "Evidenz", "in", "Verbindung", "mit", "der", "individuellen", "klinischen", "Erfahrung", "zu", "treffen", ".", "In", "diesem", "Beitrag", "werden", "zunaechst", "Beispiele", "einer", "Non", "-", "evidence", "-", "based", "Psychiatry", "\"", "\"", "aufgezeigt", ",", "ein", "klinisches", "Beispiel", "soll", "das", "Konzept", "einer", "Evidence", "-", "based", "Psychiatry", "\"", "\"", "vorstellen", ",", "am", "Ende", "schliesslich", "steht", "die", "Betrachtung", "ihrer", "Anwendung", ",", "Grenzen", "und", "Moeglichkeiten", "in", "der", "Praxis", ".", "Zum", "einen", "wird", "der", "Stellenwert", "dieser", "Methode", "fuer", "den", "klinisch", "taetigen", "Psychiater", "und", "Psychotherapeuten", "dargestellt", ".", "Zum", "anderen", "werden", "moegliche", "Konsequenzen", "diskutiert", ".", "Diese", "ergeben", "sich", "fuer", "Aufbereitung", "und", "Bereitstellung", "der", "Evidenz", "in", "Form", "von", "Datenbanken", "und", "systematischen", "Uebersichtsarbeiten", "und", "in", "der", "Notwendigkeit", "von", "Umbauprozessen", "fuer", "die", "einzelne", "Institution", "wie", "auch", "fuer", "das", "Gesundheitssystem", "als", "Ganzes", "." ]	[ "umlsterm" ]
Psychiatrie, Psychotherapie, Therapieverfahren, Praxis, Methode	DerNervenarzt.00710173.ger.abstr_task2	Sentence: In der Psychiatrie und Psychotherapie finden weiterhin viele Therapieverfahren Anwendung ohne dass ein empirischer Nachweis ihrer Wirksamkeit vorliegt . Die aus dem angloamerikanischen Sprachraum stammende " Evidence-based Medicine " bietet ein Konzept , medizinische Entscheidungen auf der Basis der besten zz . Verfuegbaren externen Evidenz in Verbindung mit der individuellen klinischen Erfahrung zu treffen . In diesem Beitrag werden zunaechst Beispiele einer Non-evidence-based Psychiatry " " aufgezeigt , ein klinisches Beispiel soll das Konzept einer Evidence-based Psychiatry " " vorstellen , am Ende schliesslich steht die Betrachtung ihrer Anwendung , Grenzen und Moeglichkeiten in der Praxis . Zum einen wird der Stellenwert dieser Methode fuer den klinisch taetigen Psychiater und Psychotherapeuten dargestellt . Zum anderen werden moegliche Konsequenzen diskutiert . Diese ergeben sich fuer Aufbereitung und Bereitstellung der Evidenz in Form von Datenbanken und systematischen Uebersichtsarbeiten und in der Notwendigkeit von Umbauprozessen fuer die einzelne Institution wie auch fuer das Gesundheitssystem als Ganzes . Instructions: please extract entity words from the input sentence	[ "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	In der Psychiatrie und Psychotherapie finden weiterhin viele Therapieverfahren Anwendung ohne dass ein empirischer Nachweis ihrer Wirksamkeit vorliegt . Die aus dem angloamerikanischen Sprachraum stammende " Evidence-based Medicine " bietet ein Konzept , medizinische Entscheidungen auf der Basis der besten zz . Verfuegbaren externen Evidenz in Verbindung mit der individuellen klinischen Erfahrung zu treffen . In diesem Beitrag werden zunaechst Beispiele einer Non-evidence-based Psychiatry " " aufgezeigt , ein klinisches Beispiel soll das Konzept einer Evidence-based Psychiatry " " vorstellen , am Ende schliesslich steht die Betrachtung ihrer Anwendung , Grenzen und Moeglichkeiten in der Praxis . Zum einen wird der Stellenwert dieser Methode fuer den klinisch taetigen Psychiater und Psychotherapeuten dargestellt . Zum anderen werden moegliche Konsequenzen diskutiert . Diese ergeben sich fuer Aufbereitung und Bereitstellung der Evidenz in Form von Datenbanken und systematischen Uebersichtsarbeiten und in der Notwendigkeit von Umbauprozessen fuer die einzelne Institution wie auch fuer das Gesundheitssystem als Ganzes .	[ "In", "der", "Psychiatrie", "und", "Psychotherapie", "finden", "weiterhin", "viele", "Therapieverfahren", "Anwendung", "ohne", "dass", "ein", "empirischer", "Nachweis", "ihrer", "Wirksamkeit", "vorliegt", ".", "Die", "aus", "dem", "angloamerikanischen", "Sprachraum", "stammende", "\"", "Evidence", "-", "based", "Medicine", "\"", "bietet", "ein", "Konzept", ",", "medizinische", "Entscheidungen", "auf", "der", "Basis", "der", "besten", "zz", ".", "Verfuegbaren", "externen", "Evidenz", "in", "Verbindung", "mit", "der", "individuellen", "klinischen", "Erfahrung", "zu", "treffen", ".", "In", "diesem", "Beitrag", "werden", "zunaechst", "Beispiele", "einer", "Non", "-", "evidence", "-", "based", "Psychiatry", "\"", "\"", "aufgezeigt", ",", "ein", "klinisches", "Beispiel", "soll", "das", "Konzept", "einer", "Evidence", "-", "based", "Psychiatry", "\"", "\"", "vorstellen", ",", "am", "Ende", "schliesslich", "steht", "die", "Betrachtung", "ihrer", "Anwendung", ",", "Grenzen", "und", "Moeglichkeiten", "in", "der", "Praxis", ".", "Zum", "einen", "wird", "der", "Stellenwert", "dieser", "Methode", "fuer", "den", "klinisch", "taetigen", "Psychiater", "und", "Psychotherapeuten", "dargestellt", ".", "Zum", "anderen", "werden", "moegliche", "Konsequenzen", "diskutiert", ".", "Diese", "ergeben", "sich", "fuer", "Aufbereitung", "und", "Bereitstellung", "der", "Evidenz", "in", "Form", "von", "Datenbanken", "und", "systematischen", "Uebersichtsarbeiten", "und", "in", "der", "Notwendigkeit", "von", "Umbauprozessen", "fuer", "die", "einzelne", "Institution", "wie", "auch", "fuer", "das", "Gesundheitssystem", "als", "Ganzes", "." ]	[ "umlsterm" ]
neurofibromatosis is a MORFOLOGIA_NEOPLASIA, neurofibromas múltiples is a MORFOLOGIA_NEOPLASIA, cáncer is a MORFOLOGIA_NEOPLASIA, neurofibromatosis is a MORFOLOGIA_NEOPLASIA, tumoración is a MORFOLOGIA_NEOPLASIA, neurofibroma is a MORFOLOGIA_NEOPLASIA, sarcoma pleomorfico de alto grado is a MORFOLOGIA_NEOPLASIA, tumor maligno de la vaina nerviosa periférica is a MORFOLOGIA_NEOPLASIA, TMVNP is a MORFOLOGIA_NEOPLASIA, tumoración is a MORFOLOGIA_NEOPLASIA, neurofibromas múltiples is a MORFOLOGIA_NEOPLASIA, neurofibromas is a MORFOLOGIA_NEOPLASIA, TMVNP is a MORFOLOGIA_NEOPLASIA, tumoración is a MORFOLOGIA_NEOPLASIA, extensión local y a distancia is a MORFOLOGIA_NEOPLASIA, tumor is a MORFOLOGIA_NEOPLASIA, tumoración is a MORFOLOGIA_NEOPLASIA, TMVNP con diferenciación rabdomiosarcomatosa is a MORFOLOGIA_NEOPLASIA, tumor de tritón is a MORFOLOGIA_NEOPLASIA, nódulo pulmonar is a MORFOLOGIA_NEOPLASIA, metástasis única con tumor is a MORFOLOGIA_NEOPLASIA, TMVNP is a MORFOLOGIA_NEOPLASIA	679_task0	Sentence: Anamnesis Se trata de una mujer de 45 años de edad, como único antecedente patológico destaca una neurofibromatosis tipo 1 diagnosticada en la infancia en forma de neurofibromas múltiples subcutáneos, efélides axilares y manchas cafe-au-lait; no había habido afectación neurológica, ósea ni ocular. Su madre fue diagnosticada de un cáncer de colon a la edad de 67 años, pero no había antecedentes familiares de neurofibromatosis. Exploración física La paciente acudió inicialmente a su Hospital de referencia en Enero de 2013 con clínica de más de un año de evolución consistente en dolor y en la aparición de una tumoración en la escápula derecha. Se realizaron estudios de imagen con ecografía de tejidos blandos donde se apreciaba una masa solida de 45 mm con vascularización y características típicas de neurofibroma y posteriormente una resonancia de escapula derecha que describió una gran masa de 15 cm con necrosis central y signos de vascularización de "características benignas", con lo cual se procedió a realizar una resección marginal en de la lesión en diciembre de 2013. Desgraciadamente, el estudio patológico informó de un sarcoma pleomorfico de alto grado, compatible con un tumor maligno de la vaina nerviosa periférica (TMVNP). Con los datos de anatomía patológica y la cirugía no compartimental sin criterios oncológicos realizada, se procede a remitir a la paciente a nuestro hospital. En ese momento la paciente se encontraba bien, aunque refería rápida reaparición del dolor en el hombro tras la cirugía; en la exploración se aprecia una tumoración fija y gomosa en la escápula derecha. Se apreciaban múltiples neurofibromas múltiples subcutáneos, efélides axilares y manchas cafe-au-lait. Pruebas complementarias » PET-TAC de extensión en febrero de 2014: muestra una masa de partes blandas de 6,2 x 2,8 cm con intenso hipermetabolismo patológico (SUVmáx 20,2 g/ml) que erosiona la escápula derecha, sugestivo de comportamiento agresivo, además se observan múltiples nódulos en la piel, todos ametabólicos, que corresponden a neurofibromas cutáneos. Diagnóstico Expuesto el caso con estos datos en la comisión de tumores, se consideró que la paciente era candidata a tratamiento QT neoadyuvante (para disminuir la extensión de la lesión y con ello la morbilidad de la cirugía) seguida de cirugía con criterios radicales y radioterapia adyuvante. La paciente es incluida en el ensayo clínico GEIS 25 de QT neoadyuvante adaptada al histiotipo (epirrubicina-ifosfamida frente a ifosfamida-VP16 en el caso de TMVNP). La paciente recibe tres ciclos de ifosfamida-VP16 entre marzo y mayo de 2014, con evidente respuesta clínica desde el primer ciclo. La evaluación tras tres ciclos mostró una reducción muy significativa, mayor del 90 % de la tumoración, que se limita prácticamente a la fosa infraespinosa, con zonas avasculares en su interior sugestivas de necrosis, y ausencia de extensión local y a distancia. Vista la excelente respuesta parcial mayor tras la QT, se procede a la planificación de la cirugía con criterios oncológicos por parte del equipo de tumores óseos, realizando escapulectomía subtotal a través del cuello de la escápula manteniendo junto a la pieza extirpada el subescapular, supraespinoso, infraespinoso y redondo menor en junio de 2014. El resultado patológico de la pieza quirúrgica muestra una celularidad mayoritariamente pleomórfica con otras áreas de morfología fusocelular pura y estroma amplio mixoide, zonas de necrosis con células espumosas y células inflamatorias mononucleadas en aproximadamente el 50% del volumen total del tumor. En el estudio inmunohistoquímico las células pleomórficas expresan diferenciación muscular estriada (vimentina + desmina + calponina + miogenina + nuclear, MYOD1 + nuclear). Las fusiformes son focalmente positivas para MyoD1, CD34, y pS100. EMA, beta-catenina, AE1/3, actina. Los bordes de resección estaban libres de tumoración. Todos estos hallazgos eran compatibles con un TMVNP con diferenciación rabdomiosarcomatosa (tumor de tritón). Se complementa el tratamiento con RT externa adyuvante para una dosis total de 66 Gy. Tratamiento QTT neoadyuvante seguida de cirugía con criterios radicales y RT adyuvante. Evolución La paciente inicia seguimiento en nuestras consultas. En enero de 2015, seis meses tras la cirugía radical, se aprecia en la TC un nódulo pulmonar posterobasal derecho que mide aproximadamente 20 mm de diámetro. La PET-TC confirma la presencia de un nódulo redondeado de 26 x 26 x 29 mm hipermetabólico (SUVmáx 5,8 g/ml) en la base del LID, que ha crecido con respecto al estudio TC previa y que no aparecía en el estudio inicial. La paciente permanecía clínicamente asintomática. Dada la presencia de metástasis única con tumor primario controlado, remitimos a la paciente a cirugía torácica para valoración de metastasectomía pulmonar. Se procedió a una cirugía exploradora en febrero de 2015, apreciándose un nódulo de gran tamaño ocupando prácticamente toda la pirámide basal con adenopatías en cisura perivasculares; se practica una lobectomía inferior derecha y una disección ganglionar paratraqueal derecha, localizando además otra adenopatía precava (también resecada). La biopsia confirma la proliferación celular mesenquimal atípica bien delimitada, no encapsulada, formando haces entrecruzados en alternancia con zonas de necrosis y degeneración de aspecto mixoide, además una población celular mayoritaria conformada por elementos fusiformes, sugestiva de TMVNP, aunque no se observa diferenciación rabdomiosarcomatosa. Los bordes quirúrgicos y las adenopatías están libres. Se considera que no hay criterios para tratamiento con QT pseudoadyuvante y la paciente sigue controles en nuestras consultas sin evidencia de enfermedad activa en el momento actual. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: MORFOLOGIA_NEOPLASIA	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Anamnesis Se trata de una mujer de 45 años de edad, como único antecedente patológico destaca una neurofibromatosis tipo 1 diagnosticada en la infancia en forma de neurofibromas múltiples subcutáneos, efélides axilares y manchas cafe-au-lait; no había habido afectación neurológica, ósea ni ocular. Su madre fue diagnosticada de un cáncer de colon a la edad de 67 años, pero no había antecedentes familiares de neurofibromatosis. Exploración física La paciente acudió inicialmente a su Hospital de referencia en Enero de 2013 con clínica de más de un año de evolución consistente en dolor y en la aparición de una tumoración en la escápula derecha. Se realizaron estudios de imagen con ecografía de tejidos blandos donde se apreciaba una masa solida de 45 mm con vascularización y características típicas de neurofibroma y posteriormente una resonancia de escapula derecha que describió una gran masa de 15 cm con necrosis central y signos de vascularización de "características benignas", con lo cual se procedió a realizar una resección marginal en de la lesión en diciembre de 2013. Desgraciadamente, el estudio patológico informó de un sarcoma pleomorfico de alto grado, compatible con un tumor maligno de la vaina nerviosa periférica (TMVNP). Con los datos de anatomía patológica y la cirugía no compartimental sin criterios oncológicos realizada, se procede a remitir a la paciente a nuestro hospital. En ese momento la paciente se encontraba bien, aunque refería rápida reaparición del dolor en el hombro tras la cirugía; en la exploración se aprecia una tumoración fija y gomosa en la escápula derecha. Se apreciaban múltiples neurofibromas múltiples subcutáneos, efélides axilares y manchas cafe-au-lait. Pruebas complementarias » PET-TAC de extensión en febrero de 2014: muestra una masa de partes blandas de 6,2 x 2,8 cm con intenso hipermetabolismo patológico (SUVmáx 20,2 g/ml) que erosiona la escápula derecha, sugestivo de comportamiento agresivo, además se observan múltiples nódulos en la piel, todos ametabólicos, que corresponden a neurofibromas cutáneos. Diagnóstico Expuesto el caso con estos datos en la comisión de tumores, se consideró que la paciente era candidata a tratamiento QT neoadyuvante (para disminuir la extensión de la lesión y con ello la morbilidad de la cirugía) seguida de cirugía con criterios radicales y radioterapia adyuvante. La paciente es incluida en el ensayo clínico GEIS 25 de QT neoadyuvante adaptada al histiotipo (epirrubicina-ifosfamida frente a ifosfamida-VP16 en el caso de TMVNP). La paciente recibe tres ciclos de ifosfamida-VP16 entre marzo y mayo de 2014, con evidente respuesta clínica desde el primer ciclo. La evaluación tras tres ciclos mostró una reducción muy significativa, mayor del 90 % de la tumoración, que se limita prácticamente a la fosa infraespinosa, con zonas avasculares en su interior sugestivas de necrosis, y ausencia de extensión local y a distancia. Vista la excelente respuesta parcial mayor tras la QT, se procede a la planificación de la cirugía con criterios oncológicos por parte del equipo de tumores óseos, realizando escapulectomía subtotal a través del cuello de la escápula manteniendo junto a la pieza extirpada el subescapular, supraespinoso, infraespinoso y redondo menor en junio de 2014. El resultado patológico de la pieza quirúrgica muestra una celularidad mayoritariamente pleomórfica con otras áreas de morfología fusocelular pura y estroma amplio mixoide, zonas de necrosis con células espumosas y células inflamatorias mononucleadas en aproximadamente el 50% del volumen total del tumor. En el estudio inmunohistoquímico las células pleomórficas expresan diferenciación muscular estriada (vimentina + desmina + calponina + miogenina + nuclear, MYOD1 + nuclear). Las fusiformes son focalmente positivas para MyoD1, CD34, y pS100. EMA, beta-catenina, AE1/3, actina. Los bordes de resección estaban libres de tumoración. Todos estos hallazgos eran compatibles con un TMVNP con diferenciación rabdomiosarcomatosa (tumor de tritón). Se complementa el tratamiento con RT externa adyuvante para una dosis total de 66 Gy. Tratamiento QTT neoadyuvante seguida de cirugía con criterios radicales y RT adyuvante. Evolución La paciente inicia seguimiento en nuestras consultas. En enero de 2015, seis meses tras la cirugía radical, se aprecia en la TC un nódulo pulmonar posterobasal derecho que mide aproximadamente 20 mm de diámetro. La PET-TC confirma la presencia de un nódulo redondeado de 26 x 26 x 29 mm hipermetabólico (SUVmáx 5,8 g/ml) en la base del LID, que ha crecido con respecto al estudio TC previa y que no aparecía en el estudio inicial. La paciente permanecía clínicamente asintomática. Dada la presencia de metástasis única con tumor primario controlado, remitimos a la paciente a cirugía torácica para valoración de metastasectomía pulmonar. Se procedió a una cirugía exploradora en febrero de 2015, apreciándose un nódulo de gran tamaño ocupando prácticamente toda la pirámide basal con adenopatías en cisura perivasculares; se practica una lobectomía inferior derecha y una disección ganglionar paratraqueal derecha, localizando además otra adenopatía precava (también resecada). La biopsia confirma la proliferación celular mesenquimal atípica bien delimitada, no encapsulada, formando haces entrecruzados en alternancia con zonas de necrosis y degeneración de aspecto mixoide, además una población celular mayoritaria conformada por elementos fusiformes, sugestiva de TMVNP, aunque no se observa diferenciación rabdomiosarcomatosa. Los bordes quirúrgicos y las adenopatías están libres. Se considera que no hay criterios para tratamiento con QT pseudoadyuvante y la paciente sigue controles en nuestras consultas sin evidencia de enfermedad activa en el momento actual.	[ "Anamnesis", "\n", "Se", "trata", "de", "una", "mujer", "de", "45", "años", "de", "edad", ",", "como", "único", "antecedente", "patológico", "destaca", "una", "neurofibromatosis", "tipo", "1", "diagnosticada", "en", "la", "infancia", "en", "forma", "de", "neurofibromas", "múltiples", "subcutáneos", ",", "efélides", "axilares", "y", "manchas", "cafe", "-", "au", "-", "lait", ";", "no", "había", "habido", "afectación", "neurológica", ",", "ósea", "ni", "ocular", ".", "Su", "madre", "fue", "diagnosticada", "de", "un", "cáncer", "de", "colon", "a", "la", "edad", "de", "67", "años", ",", "pero", "no", "había", "antecedentes", "familiares", "de", "neurofibromatosis", ".", "\n\n", "Exploración", "física", "\n", "La", "paciente", "acudió", "inicialmente", "a", "su", "Hospital", "de", "referencia", "en", "Enero", "de", "2013", "con", "clínica", "de", "más", "de", "un", "año", "de", "evolución", "consistente", "en", "dolor", "y", "en", "la", "aparición", "de", "una", "tumoración", "en", "la", "escápula", "derecha", ".", "Se", "realizaron", "estudios", "de", "imagen", "con", "ecografía", "de", "tejidos", "blandos", "donde", "se", "apreciaba", "una", "masa", "solida", "de", "45", "mm", "con", "vascularización", "y", "características", "típicas", "de", "neurofibroma", "y", "posteriormente", "una", "resonancia", "de", "escapula", "derecha", "que", "describió", "una", "gran", "masa", "de", "15", "cm", "con", "necrosis", "central", "y", "signos", "de", "vascularización", "de", "\"", "características", "benignas", "\"", ",", "con", "lo", "cual", "se", "procedió", "a", "realizar", "una", "resección", "marginal", "en", "de", "la", "lesión", "en", "diciembre", "de", "2013", ".", "Desgraciadamente", ",", "el", "estudio", "patológico", "informó", "de", "un", "sarcoma", "pleomorfico", "de", "alto", "grado", ",", "compatible", "con", "un", "tumor", "maligno", "de", "la", "vaina", "nerviosa", "periférica", "(", "TMVNP", ")", ".", "\n\n", "Con", "los", "datos", "de", "anatomía", "patológica", "y", "la", "cirugía", "no", "compartimental", "sin", "criterios", "oncológicos", "realizada", ",", "se", "procede", "a", "remitir", "a", "la", "paciente", "a", "nuestro", "hospital", ".", "En", "ese", "momento", "la", "paciente", "se", "encontraba", "bien", ",", "aunque", "refería", "rápida", "reaparición", "del", "dolor", "en", "el", "hombro", "tras", "la", "cirugía", ";", "en", "la", "exploración", "se", "aprecia", "una", "tumoración", "fija", "y", "gomosa", "en", "la", "escápula", "derecha", ".", "Se", "apreciaban", "múltiples", "neurofibromas", "múltiples", "subcutáneos", ",", "efélides", "axilares", "y", "manchas", "cafe", "-", "au", "-", "lait", ".", "\n\n", "Pruebas", "complementarias", "\n", "»", "PET", "-", "TAC", "de", "extensión", "en", "febrero", "de", "2014", ":", "muestra", "una", "masa", "de", "partes", "blandas", "de", "6,2", "x", "2,8", "cm", "con", "intenso", "hipermetabolismo", "patológico", "(", "SUVmáx", "20,2", "g", "/", "ml", ")", "que", "erosiona", "la", "escápula", "derecha", ",", "sugestivo", "de", "comportamiento", "agresivo", ",", "además", "se", "observan", "múltiples", "nódulos", "en", "la", "piel", ",", "todos", "ametabólicos", ",", "que", "corresponden", "a", "neurofibromas", "cutáneos", ".", "\n\n", "Diagnóstico", "\n", "Expuesto", "el", "caso", "con", "estos", "datos", "en", "la", "comisión", "de", "tumores", ",", "se", "consideró", "que", "la", "paciente", "era", "candidata", "a", "tratamiento", "QT", "neoadyuvante", "(", "para", "disminuir", "la", "extensión", "de", "la", "lesión", "y", "con", "ello", "la", "morbilidad", "de", "la", "cirugía", ")", "seguida", "de", "cirugía", "con", "criterios", "radicales", "y", "radioterapia", "adyuvante", ".", "\n\n", "La", "paciente", "es", "incluida", "en", "el", "ensayo", "clínico", "GEIS", "25", "de", "QT", "neoadyuvante", "adaptada", "al", "histiotipo", "(", "epirrubicina", "-", "ifosfamida", "frente", "a", "ifosfamida", "-", "VP16", "en", "el", "caso", "de", "TMVNP", ")", ".", "La", "paciente", "recibe", "tres", "ciclos", "de", "ifosfamida", "-", "VP16", "entre", "marzo", "y", "mayo", "de", "2014", ",", "con", "evidente", "respuesta", "clínica", "desde", "el", "primer", "ciclo", ".", "La", "evaluación", "tras", "tres", "ciclos", "mostró", "una", "reducción", "muy", "significativa", ",", "mayor", "del", "90", "%", "de", "la", "tumoración", ",", "que", "se", "limita", "prácticamente", "a", "la", "fosa", "infraespinosa", ",", "con", "zonas", "avasculares", "en", "su", "interior", "sugestivas", "de", "necrosis", ",", "y", "ausencia", "de", "extensión", "local", "y", "a", "distancia", ".", "\n\n", "Vista", "la", "excelente", "respuesta", "parcial", "mayor", "tras", "la", "QT", ",", "se", "procede", "a", "la", "planificación", "de", "la", "cirugía", "con", "criterios", "oncológicos", "por", "parte", "del", "equipo", "de", "tumores", "óseos", ",", "realizando", "escapulectomía", "subtotal", "a", "través", "del", "cuello", "de", "la", "escápula", "manteniendo", "junto", "a", "la", "pieza", "extirpada", "el", "subescapular", ",", "supraespinoso", ",", "infraespinoso", "y", "redondo", "menor", "en", "junio", "de", "2014", ".", "\n\n", "El", "resultado", "patológico", "de", "la", "pieza", "quirúrgica", "muestra", "una", "celularidad", "mayoritariamente", "pleomórfica", "con", "otras", "áreas", "de", "morfología", "fusocelular", "pura", "y", "estroma", "amplio", "mixoide", ",", "zonas", "de", "necrosis", "con", "células", "espumosas", "y", "células", "inflamatorias", "mononucleadas", "en", "aproximadamente", "el", "50", "%", "del", "volumen", "total", "del", "tumor", ".", "En", "el", "estudio", "inmunohistoquímico", "las", "células", "pleomórficas", "expresan", "diferenciación", "muscular", "estriada", "(", "vimentina", "+", "desmina", "+", "calponina", "+", "miogenina", "+", "nuclear", ",", "MYOD1", "+", "nuclear", ")", ".", "Las", "fusiformes", "son", "focalmente", "positivas", "para", "MyoD1", ",", "CD34", ",", "y", "pS100", ".", "EMA", ",", "beta", "-", "catenina", ",", "AE1/3", ",", "actina", ".", "Los", "bordes", "de", "resección", "estaban", "libres", "de", "tumoración", ".", "Todos", "estos", "hallazgos", "eran", "compatibles", "con", "un", "TMVNP", "con", "diferenciación", "rabdomiosarcomatosa", "(", "tumor", "de", "tritón", ")", ".", "\n\n", "Se", "complementa", "el", "tratamiento", "con", "RT", "externa", "adyuvante", "para", "una", "dosis", "total", "de", "66", "Gy", ".", "\n\n", "Tratamiento", "\n", "QTT", "neoadyuvante", "seguida", "de", "cirugía", "con", "criterios", "radicales", "y", "RT", "adyuvante", ".", "\n\n", "Evolución", "\n", "La", "paciente", "inicia", "seguimiento", "en", "nuestras", "consultas", ".", "En", "enero", "de", "2015", ",", "seis", "meses", "tras", "la", "cirugía", "radical", ",", "se", "aprecia", "en", "la", "TC", "un", "nódulo", "pulmonar", "posterobasal", "derecho", "que", "mide", "aproximadamente", "20", "mm", "de", "diámetro", ".", "La", "PET", "-", "TC", "confirma", "la", "presencia", "de", "un", "nódulo", "redondeado", "de", "26", "x", "26", "x", "29", "mm", "hipermetabólico", "(", "SUVmáx", "5,8", "g", "/", "ml", ")", "en", "la", "base", "del", "LID", ",", "que", "ha", "crecido", "con", "respecto", "al", "estudio", "TC", "previa", "y", "que", "no", "aparecía", "en", "el", "estudio", "inicial", ".", "La", "paciente", "permanecía", "clínicamente", "asintomática", ".", "\n\n", "Dada", "la", "presencia", "de", "metástasis", "única", "con", "tumor", "primario", "controlado", ",", "remitimos", "a", "la", "paciente", "a", "cirugía", "torácica", "para", "valoración", "de", "metastasectomía", "pulmonar", ".", "\n\n", "Se", "procedió", "a", "una", "cirugía", "exploradora", "en", "febrero", "de", "2015", ",", "apreciándose", "un", "nódulo", "de", "gran", "tamaño", "ocupando", "prácticamente", "toda", "la", "pirámide", "basal", "con", "adenopatías", "en", "cisura", "perivasculares", ";", "se", "practica", "una", "lobectomía", "inferior", "derecha", "y", "una", "disección", "ganglionar", "paratraqueal", "derecha", ",", "localizando", "además", "otra", "adenopatía", "precava", "(", "también", "resecada", ")", ".", "La", "biopsia", "confirma", "la", "proliferación", "celular", "mesenquimal", "atípica", "bien", "delimitada", ",", "no", "encapsulada", ",", "formando", "haces", "entrecruzados", "en", "alternancia", "con", "zonas", "de", "necrosis", "y", "degeneración", "de", "aspecto", "mixoide", ",", "además", "una", "población", "celular", "mayoritaria", "conformada", "por", "elementos", "fusiformes", ",", "sugestiva", "de", "TMVNP", ",", "aunque", "no", "se", "observa", "diferenciación", "rabdomiosarcomatosa", ".", "Los", "bordes", "quirúrgicos", "y", "las", "adenopatías", "están", "libres", ".", "\n\n", "Se", "considera", "que", "no", "hay", "criterios", "para", "tratamiento", "con", "QT", "pseudoadyuvante", "y", "la", "paciente", "sigue", "controles", "en", "nuestras", "consultas", "sin", "evidencia", "de", "enfermedad", "activa", "en", "el", "momento", "actual", "." ]	[ "MORFOLOGIA_NEOPLASIA" ]
neurofibromatosis is a MORFOLOGIA_NEOPLASIA, neurofibromas múltiples is a MORFOLOGIA_NEOPLASIA, cáncer is a MORFOLOGIA_NEOPLASIA, neurofibromatosis is a MORFOLOGIA_NEOPLASIA, tumoración is a MORFOLOGIA_NEOPLASIA, neurofibroma is a MORFOLOGIA_NEOPLASIA, sarcoma pleomorfico de alto grado is a MORFOLOGIA_NEOPLASIA, tumor maligno de la vaina nerviosa periférica is a MORFOLOGIA_NEOPLASIA, TMVNP is a MORFOLOGIA_NEOPLASIA, tumoración is a MORFOLOGIA_NEOPLASIA, neurofibromas múltiples is a MORFOLOGIA_NEOPLASIA, neurofibromas is a MORFOLOGIA_NEOPLASIA, TMVNP is a MORFOLOGIA_NEOPLASIA, tumoración is a MORFOLOGIA_NEOPLASIA, extensión local y a distancia is a MORFOLOGIA_NEOPLASIA, tumor is a MORFOLOGIA_NEOPLASIA, tumoración is a MORFOLOGIA_NEOPLASIA, TMVNP con diferenciación rabdomiosarcomatosa is a MORFOLOGIA_NEOPLASIA, tumor de tritón is a MORFOLOGIA_NEOPLASIA, nódulo pulmonar is a MORFOLOGIA_NEOPLASIA, metástasis única con tumor is a MORFOLOGIA_NEOPLASIA, TMVNP is a MORFOLOGIA_NEOPLASIA	679_task1	Sentence: Anamnesis Se trata de una mujer de 45 años de edad, como único antecedente patológico destaca una neurofibromatosis tipo 1 diagnosticada en la infancia en forma de neurofibromas múltiples subcutáneos, efélides axilares y manchas cafe-au-lait; no había habido afectación neurológica, ósea ni ocular. Su madre fue diagnosticada de un cáncer de colon a la edad de 67 años, pero no había antecedentes familiares de neurofibromatosis. Exploración física La paciente acudió inicialmente a su Hospital de referencia en Enero de 2013 con clínica de más de un año de evolución consistente en dolor y en la aparición de una tumoración en la escápula derecha. Se realizaron estudios de imagen con ecografía de tejidos blandos donde se apreciaba una masa solida de 45 mm con vascularización y características típicas de neurofibroma y posteriormente una resonancia de escapula derecha que describió una gran masa de 15 cm con necrosis central y signos de vascularización de "características benignas", con lo cual se procedió a realizar una resección marginal en de la lesión en diciembre de 2013. Desgraciadamente, el estudio patológico informó de un sarcoma pleomorfico de alto grado, compatible con un tumor maligno de la vaina nerviosa periférica (TMVNP). Con los datos de anatomía patológica y la cirugía no compartimental sin criterios oncológicos realizada, se procede a remitir a la paciente a nuestro hospital. En ese momento la paciente se encontraba bien, aunque refería rápida reaparición del dolor en el hombro tras la cirugía; en la exploración se aprecia una tumoración fija y gomosa en la escápula derecha. Se apreciaban múltiples neurofibromas múltiples subcutáneos, efélides axilares y manchas cafe-au-lait. Pruebas complementarias » PET-TAC de extensión en febrero de 2014: muestra una masa de partes blandas de 6,2 x 2,8 cm con intenso hipermetabolismo patológico (SUVmáx 20,2 g/ml) que erosiona la escápula derecha, sugestivo de comportamiento agresivo, además se observan múltiples nódulos en la piel, todos ametabólicos, que corresponden a neurofibromas cutáneos. Diagnóstico Expuesto el caso con estos datos en la comisión de tumores, se consideró que la paciente era candidata a tratamiento QT neoadyuvante (para disminuir la extensión de la lesión y con ello la morbilidad de la cirugía) seguida de cirugía con criterios radicales y radioterapia adyuvante. La paciente es incluida en el ensayo clínico GEIS 25 de QT neoadyuvante adaptada al histiotipo (epirrubicina-ifosfamida frente a ifosfamida-VP16 en el caso de TMVNP). La paciente recibe tres ciclos de ifosfamida-VP16 entre marzo y mayo de 2014, con evidente respuesta clínica desde el primer ciclo. La evaluación tras tres ciclos mostró una reducción muy significativa, mayor del 90 % de la tumoración, que se limita prácticamente a la fosa infraespinosa, con zonas avasculares en su interior sugestivas de necrosis, y ausencia de extensión local y a distancia. Vista la excelente respuesta parcial mayor tras la QT, se procede a la planificación de la cirugía con criterios oncológicos por parte del equipo de tumores óseos, realizando escapulectomía subtotal a través del cuello de la escápula manteniendo junto a la pieza extirpada el subescapular, supraespinoso, infraespinoso y redondo menor en junio de 2014. El resultado patológico de la pieza quirúrgica muestra una celularidad mayoritariamente pleomórfica con otras áreas de morfología fusocelular pura y estroma amplio mixoide, zonas de necrosis con células espumosas y células inflamatorias mononucleadas en aproximadamente el 50% del volumen total del tumor. En el estudio inmunohistoquímico las células pleomórficas expresan diferenciación muscular estriada (vimentina + desmina + calponina + miogenina + nuclear, MYOD1 + nuclear). Las fusiformes son focalmente positivas para MyoD1, CD34, y pS100. EMA, beta-catenina, AE1/3, actina. Los bordes de resección estaban libres de tumoración. Todos estos hallazgos eran compatibles con un TMVNP con diferenciación rabdomiosarcomatosa (tumor de tritón). Se complementa el tratamiento con RT externa adyuvante para una dosis total de 66 Gy. Tratamiento QTT neoadyuvante seguida de cirugía con criterios radicales y RT adyuvante. Evolución La paciente inicia seguimiento en nuestras consultas. En enero de 2015, seis meses tras la cirugía radical, se aprecia en la TC un nódulo pulmonar posterobasal derecho que mide aproximadamente 20 mm de diámetro. La PET-TC confirma la presencia de un nódulo redondeado de 26 x 26 x 29 mm hipermetabólico (SUVmáx 5,8 g/ml) en la base del LID, que ha crecido con respecto al estudio TC previa y que no aparecía en el estudio inicial. La paciente permanecía clínicamente asintomática. Dada la presencia de metástasis única con tumor primario controlado, remitimos a la paciente a cirugía torácica para valoración de metastasectomía pulmonar. Se procedió a una cirugía exploradora en febrero de 2015, apreciándose un nódulo de gran tamaño ocupando prácticamente toda la pirámide basal con adenopatías en cisura perivasculares; se practica una lobectomía inferior derecha y una disección ganglionar paratraqueal derecha, localizando además otra adenopatía precava (también resecada). La biopsia confirma la proliferación celular mesenquimal atípica bien delimitada, no encapsulada, formando haces entrecruzados en alternancia con zonas de necrosis y degeneración de aspecto mixoide, además una población celular mayoritaria conformada por elementos fusiformes, sugestiva de TMVNP, aunque no se observa diferenciación rabdomiosarcomatosa. Los bordes quirúrgicos y las adenopatías están libres. Se considera que no hay criterios para tratamiento con QT pseudoadyuvante y la paciente sigue controles en nuestras consultas sin evidencia de enfermedad activa en el momento actual. Instructions: please typing these entity words according to sentence: neurofibromatosis, neurofibromas múltiples, cáncer, neurofibromatosis, tumoración, neurofibroma, sarcoma pleomorfico de alto grado, tumor maligno de la vaina nerviosa periférica, TMVNP, tumoración, neurofibromas múltiples, neurofibromas, TMVNP, tumoración, extensión local y a distancia, tumor, tumoración, TMVNP con diferenciación rabdomiosarcomatosa, tumor de tritón, nódulo pulmonar, metástasis única con tumor, TMVNP Options: MORFOLOGIA_NEOPLASIA	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Anamnesis Se trata de una mujer de 45 años de edad, como único antecedente patológico destaca una neurofibromatosis tipo 1 diagnosticada en la infancia en forma de neurofibromas múltiples subcutáneos, efélides axilares y manchas cafe-au-lait; no había habido afectación neurológica, ósea ni ocular. Su madre fue diagnosticada de un cáncer de colon a la edad de 67 años, pero no había antecedentes familiares de neurofibromatosis. Exploración física La paciente acudió inicialmente a su Hospital de referencia en Enero de 2013 con clínica de más de un año de evolución consistente en dolor y en la aparición de una tumoración en la escápula derecha. Se realizaron estudios de imagen con ecografía de tejidos blandos donde se apreciaba una masa solida de 45 mm con vascularización y características típicas de neurofibroma y posteriormente una resonancia de escapula derecha que describió una gran masa de 15 cm con necrosis central y signos de vascularización de "características benignas", con lo cual se procedió a realizar una resección marginal en de la lesión en diciembre de 2013. Desgraciadamente, el estudio patológico informó de un sarcoma pleomorfico de alto grado, compatible con un tumor maligno de la vaina nerviosa periférica (TMVNP). Con los datos de anatomía patológica y la cirugía no compartimental sin criterios oncológicos realizada, se procede a remitir a la paciente a nuestro hospital. En ese momento la paciente se encontraba bien, aunque refería rápida reaparición del dolor en el hombro tras la cirugía; en la exploración se aprecia una tumoración fija y gomosa en la escápula derecha. Se apreciaban múltiples neurofibromas múltiples subcutáneos, efélides axilares y manchas cafe-au-lait. Pruebas complementarias » PET-TAC de extensión en febrero de 2014: muestra una masa de partes blandas de 6,2 x 2,8 cm con intenso hipermetabolismo patológico (SUVmáx 20,2 g/ml) que erosiona la escápula derecha, sugestivo de comportamiento agresivo, además se observan múltiples nódulos en la piel, todos ametabólicos, que corresponden a neurofibromas cutáneos. Diagnóstico Expuesto el caso con estos datos en la comisión de tumores, se consideró que la paciente era candidata a tratamiento QT neoadyuvante (para disminuir la extensión de la lesión y con ello la morbilidad de la cirugía) seguida de cirugía con criterios radicales y radioterapia adyuvante. La paciente es incluida en el ensayo clínico GEIS 25 de QT neoadyuvante adaptada al histiotipo (epirrubicina-ifosfamida frente a ifosfamida-VP16 en el caso de TMVNP). La paciente recibe tres ciclos de ifosfamida-VP16 entre marzo y mayo de 2014, con evidente respuesta clínica desde el primer ciclo. La evaluación tras tres ciclos mostró una reducción muy significativa, mayor del 90 % de la tumoración, que se limita prácticamente a la fosa infraespinosa, con zonas avasculares en su interior sugestivas de necrosis, y ausencia de extensión local y a distancia. Vista la excelente respuesta parcial mayor tras la QT, se procede a la planificación de la cirugía con criterios oncológicos por parte del equipo de tumores óseos, realizando escapulectomía subtotal a través del cuello de la escápula manteniendo junto a la pieza extirpada el subescapular, supraespinoso, infraespinoso y redondo menor en junio de 2014. El resultado patológico de la pieza quirúrgica muestra una celularidad mayoritariamente pleomórfica con otras áreas de morfología fusocelular pura y estroma amplio mixoide, zonas de necrosis con células espumosas y células inflamatorias mononucleadas en aproximadamente el 50% del volumen total del tumor. En el estudio inmunohistoquímico las células pleomórficas expresan diferenciación muscular estriada (vimentina + desmina + calponina + miogenina + nuclear, MYOD1 + nuclear). Las fusiformes son focalmente positivas para MyoD1, CD34, y pS100. EMA, beta-catenina, AE1/3, actina. Los bordes de resección estaban libres de tumoración. Todos estos hallazgos eran compatibles con un TMVNP con diferenciación rabdomiosarcomatosa (tumor de tritón). Se complementa el tratamiento con RT externa adyuvante para una dosis total de 66 Gy. Tratamiento QTT neoadyuvante seguida de cirugía con criterios radicales y RT adyuvante. Evolución La paciente inicia seguimiento en nuestras consultas. En enero de 2015, seis meses tras la cirugía radical, se aprecia en la TC un nódulo pulmonar posterobasal derecho que mide aproximadamente 20 mm de diámetro. La PET-TC confirma la presencia de un nódulo redondeado de 26 x 26 x 29 mm hipermetabólico (SUVmáx 5,8 g/ml) en la base del LID, que ha crecido con respecto al estudio TC previa y que no aparecía en el estudio inicial. La paciente permanecía clínicamente asintomática. Dada la presencia de metástasis única con tumor primario controlado, remitimos a la paciente a cirugía torácica para valoración de metastasectomía pulmonar. Se procedió a una cirugía exploradora en febrero de 2015, apreciándose un nódulo de gran tamaño ocupando prácticamente toda la pirámide basal con adenopatías en cisura perivasculares; se practica una lobectomía inferior derecha y una disección ganglionar paratraqueal derecha, localizando además otra adenopatía precava (también resecada). La biopsia confirma la proliferación celular mesenquimal atípica bien delimitada, no encapsulada, formando haces entrecruzados en alternancia con zonas de necrosis y degeneración de aspecto mixoide, además una población celular mayoritaria conformada por elementos fusiformes, sugestiva de TMVNP, aunque no se observa diferenciación rabdomiosarcomatosa. Los bordes quirúrgicos y las adenopatías están libres. Se considera que no hay criterios para tratamiento con QT pseudoadyuvante y la paciente sigue controles en nuestras consultas sin evidencia de enfermedad activa en el momento actual.	[ "Anamnesis", "\n", "Se", "trata", "de", "una", "mujer", "de", "45", "años", "de", "edad", ",", "como", "único", "antecedente", "patológico", "destaca", "una", "neurofibromatosis", "tipo", "1", "diagnosticada", "en", "la", "infancia", "en", "forma", "de", "neurofibromas", "múltiples", "subcutáneos", ",", "efélides", "axilares", "y", "manchas", "cafe", "-", "au", "-", "lait", ";", "no", "había", "habido", "afectación", "neurológica", ",", "ósea", "ni", "ocular", ".", "Su", "madre", "fue", "diagnosticada", "de", "un", "cáncer", "de", "colon", "a", "la", "edad", "de", "67", "años", ",", "pero", "no", "había", "antecedentes", "familiares", "de", "neurofibromatosis", ".", "\n\n", "Exploración", "física", "\n", "La", "paciente", "acudió", "inicialmente", "a", "su", "Hospital", "de", "referencia", "en", "Enero", "de", "2013", "con", "clínica", "de", "más", "de", "un", "año", "de", "evolución", "consistente", "en", "dolor", "y", "en", "la", "aparición", "de", "una", "tumoración", "en", "la", "escápula", "derecha", ".", "Se", "realizaron", "estudios", "de", "imagen", "con", "ecografía", "de", "tejidos", "blandos", "donde", "se", "apreciaba", "una", "masa", "solida", "de", "45", "mm", "con", "vascularización", "y", "características", "típicas", "de", "neurofibroma", "y", "posteriormente", "una", "resonancia", "de", "escapula", "derecha", "que", "describió", "una", "gran", "masa", "de", "15", "cm", "con", "necrosis", "central", "y", "signos", "de", "vascularización", "de", "\"", "características", "benignas", "\"", ",", "con", "lo", "cual", "se", "procedió", "a", "realizar", "una", "resección", "marginal", "en", "de", "la", "lesión", "en", "diciembre", "de", "2013", ".", "Desgraciadamente", ",", "el", "estudio", "patológico", "informó", "de", "un", "sarcoma", "pleomorfico", "de", "alto", "grado", ",", "compatible", "con", "un", "tumor", "maligno", "de", "la", "vaina", "nerviosa", "periférica", "(", "TMVNP", ")", ".", "\n\n", "Con", "los", "datos", "de", "anatomía", "patológica", "y", "la", "cirugía", "no", "compartimental", "sin", "criterios", "oncológicos", "realizada", ",", "se", "procede", "a", "remitir", "a", "la", "paciente", "a", "nuestro", "hospital", ".", "En", "ese", "momento", "la", "paciente", "se", "encontraba", "bien", ",", "aunque", "refería", "rápida", "reaparición", "del", "dolor", "en", "el", "hombro", "tras", "la", "cirugía", ";", "en", "la", "exploración", "se", "aprecia", "una", "tumoración", "fija", "y", "gomosa", "en", "la", "escápula", "derecha", ".", "Se", "apreciaban", "múltiples", "neurofibromas", "múltiples", "subcutáneos", ",", "efélides", "axilares", "y", "manchas", "cafe", "-", "au", "-", "lait", ".", "\n\n", "Pruebas", "complementarias", "\n", "»", "PET", "-", "TAC", "de", "extensión", "en", "febrero", "de", "2014", ":", "muestra", "una", "masa", "de", "partes", "blandas", "de", "6,2", "x", "2,8", "cm", "con", "intenso", "hipermetabolismo", "patológico", "(", "SUVmáx", "20,2", "g", "/", "ml", ")", "que", "erosiona", "la", "escápula", "derecha", ",", "sugestivo", "de", "comportamiento", "agresivo", ",", "además", "se", "observan", "múltiples", "nódulos", "en", "la", "piel", ",", "todos", "ametabólicos", ",", "que", "corresponden", "a", "neurofibromas", "cutáneos", ".", "\n\n", "Diagnóstico", "\n", "Expuesto", "el", "caso", "con", "estos", "datos", "en", "la", "comisión", "de", "tumores", ",", "se", "consideró", "que", "la", "paciente", "era", "candidata", "a", "tratamiento", "QT", "neoadyuvante", "(", "para", "disminuir", "la", "extensión", "de", "la", "lesión", "y", "con", "ello", "la", "morbilidad", "de", "la", "cirugía", ")", "seguida", "de", "cirugía", "con", "criterios", "radicales", "y", "radioterapia", "adyuvante", ".", "\n\n", "La", "paciente", "es", "incluida", "en", "el", "ensayo", "clínico", "GEIS", "25", "de", "QT", "neoadyuvante", "adaptada", "al", "histiotipo", "(", "epirrubicina", "-", "ifosfamida", "frente", "a", "ifosfamida", "-", "VP16", "en", "el", "caso", "de", "TMVNP", ")", ".", "La", "paciente", "recibe", "tres", "ciclos", "de", "ifosfamida", "-", "VP16", "entre", "marzo", "y", "mayo", "de", "2014", ",", "con", "evidente", "respuesta", "clínica", "desde", "el", "primer", "ciclo", ".", "La", "evaluación", "tras", "tres", "ciclos", "mostró", "una", "reducción", "muy", "significativa", ",", "mayor", "del", "90", "%", "de", "la", "tumoración", ",", "que", "se", "limita", "prácticamente", "a", "la", "fosa", "infraespinosa", ",", "con", "zonas", "avasculares", "en", "su", "interior", "sugestivas", "de", "necrosis", ",", "y", "ausencia", "de", "extensión", "local", "y", "a", "distancia", ".", "\n\n", "Vista", "la", "excelente", "respuesta", "parcial", "mayor", "tras", "la", "QT", ",", "se", "procede", "a", "la", "planificación", "de", "la", "cirugía", "con", "criterios", "oncológicos", "por", "parte", "del", "equipo", "de", "tumores", "óseos", ",", "realizando", "escapulectomía", "subtotal", "a", "través", "del", "cuello", "de", "la", "escápula", "manteniendo", "junto", "a", "la", "pieza", "extirpada", "el", "subescapular", ",", "supraespinoso", ",", "infraespinoso", "y", "redondo", "menor", "en", "junio", "de", "2014", ".", "\n\n", "El", "resultado", "patológico", "de", "la", "pieza", "quirúrgica", "muestra", "una", "celularidad", "mayoritariamente", "pleomórfica", "con", "otras", "áreas", "de", "morfología", "fusocelular", "pura", "y", "estroma", "amplio", "mixoide", ",", "zonas", "de", "necrosis", "con", "células", "espumosas", "y", "células", "inflamatorias", "mononucleadas", "en", "aproximadamente", "el", "50", "%", "del", "volumen", "total", "del", "tumor", ".", "En", "el", "estudio", "inmunohistoquímico", "las", "células", "pleomórficas", "expresan", "diferenciación", "muscular", "estriada", "(", "vimentina", "+", "desmina", "+", "calponina", "+", "miogenina", "+", "nuclear", ",", "MYOD1", "+", "nuclear", ")", ".", "Las", "fusiformes", "son", "focalmente", "positivas", "para", "MyoD1", ",", "CD34", ",", "y", "pS100", ".", "EMA", ",", "beta", "-", "catenina", ",", "AE1/3", ",", "actina", ".", "Los", "bordes", "de", "resección", "estaban", "libres", "de", "tumoración", ".", "Todos", "estos", "hallazgos", "eran", "compatibles", "con", "un", "TMVNP", "con", "diferenciación", "rabdomiosarcomatosa", "(", "tumor", "de", "tritón", ")", ".", "\n\n", "Se", "complementa", "el", "tratamiento", "con", "RT", "externa", "adyuvante", "para", "una", "dosis", "total", "de", "66", "Gy", ".", "\n\n", "Tratamiento", "\n", "QTT", "neoadyuvante", "seguida", "de", "cirugía", "con", "criterios", "radicales", "y", "RT", "adyuvante", ".", "\n\n", "Evolución", "\n", "La", "paciente", "inicia", "seguimiento", "en", "nuestras", "consultas", ".", "En", "enero", "de", "2015", ",", "seis", "meses", "tras", "la", "cirugía", "radical", ",", "se", "aprecia", "en", "la", "TC", "un", "nódulo", "pulmonar", "posterobasal", "derecho", "que", "mide", "aproximadamente", "20", "mm", "de", "diámetro", ".", "La", "PET", "-", "TC", "confirma", "la", "presencia", "de", "un", "nódulo", "redondeado", "de", "26", "x", "26", "x", "29", "mm", "hipermetabólico", "(", "SUVmáx", "5,8", "g", "/", "ml", ")", "en", "la", "base", "del", "LID", ",", "que", "ha", "crecido", "con", "respecto", "al", "estudio", "TC", "previa", "y", "que", "no", "aparecía", "en", "el", "estudio", "inicial", ".", "La", "paciente", "permanecía", "clínicamente", "asintomática", ".", "\n\n", "Dada", "la", "presencia", "de", "metástasis", "única", "con", "tumor", "primario", "controlado", ",", "remitimos", "a", "la", "paciente", "a", "cirugía", "torácica", "para", "valoración", "de", "metastasectomía", "pulmonar", ".", "\n\n", "Se", "procedió", "a", "una", "cirugía", "exploradora", "en", "febrero", "de", "2015", ",", "apreciándose", "un", "nódulo", "de", "gran", "tamaño", "ocupando", "prácticamente", "toda", "la", "pirámide", "basal", "con", "adenopatías", "en", "cisura", "perivasculares", ";", "se", "practica", "una", "lobectomía", "inferior", "derecha", "y", "una", "disección", "ganglionar", "paratraqueal", "derecha", ",", "localizando", "además", "otra", "adenopatía", "precava", "(", "también", "resecada", ")", ".", "La", "biopsia", "confirma", "la", "proliferación", "celular", "mesenquimal", "atípica", "bien", "delimitada", ",", "no", "encapsulada", ",", "formando", "haces", "entrecruzados", "en", "alternancia", "con", "zonas", "de", "necrosis", "y", "degeneración", "de", "aspecto", "mixoide", ",", "además", "una", "población", "celular", "mayoritaria", "conformada", "por", "elementos", "fusiformes", ",", "sugestiva", "de", "TMVNP", ",", "aunque", "no", "se", "observa", "diferenciación", "rabdomiosarcomatosa", ".", "Los", "bordes", "quirúrgicos", "y", "las", "adenopatías", "están", "libres", ".", "\n\n", "Se", "considera", "que", "no", "hay", "criterios", "para", "tratamiento", "con", "QT", "pseudoadyuvante", "y", "la", "paciente", "sigue", "controles", "en", "nuestras", "consultas", "sin", "evidencia", "de", "enfermedad", "activa", "en", "el", "momento", "actual", "." ]	[ "MORFOLOGIA_NEOPLASIA" ]
neurofibromatosis, neurofibromas múltiples, cáncer, neurofibromatosis, tumoración, neurofibroma, sarcoma pleomorfico de alto grado, tumor maligno de la vaina nerviosa periférica, TMVNP, tumoración, neurofibromas múltiples, neurofibromas, TMVNP, tumoración, extensión local y a distancia, tumor, tumoración, TMVNP con diferenciación rabdomiosarcomatosa, tumor de tritón, nódulo pulmonar, metástasis única con tumor, TMVNP	679_task2	Sentence: Anamnesis Se trata de una mujer de 45 años de edad, como único antecedente patológico destaca una neurofibromatosis tipo 1 diagnosticada en la infancia en forma de neurofibromas múltiples subcutáneos, efélides axilares y manchas cafe-au-lait; no había habido afectación neurológica, ósea ni ocular. Su madre fue diagnosticada de un cáncer de colon a la edad de 67 años, pero no había antecedentes familiares de neurofibromatosis. Exploración física La paciente acudió inicialmente a su Hospital de referencia en Enero de 2013 con clínica de más de un año de evolución consistente en dolor y en la aparición de una tumoración en la escápula derecha. Se realizaron estudios de imagen con ecografía de tejidos blandos donde se apreciaba una masa solida de 45 mm con vascularización y características típicas de neurofibroma y posteriormente una resonancia de escapula derecha que describió una gran masa de 15 cm con necrosis central y signos de vascularización de "características benignas", con lo cual se procedió a realizar una resección marginal en de la lesión en diciembre de 2013. Desgraciadamente, el estudio patológico informó de un sarcoma pleomorfico de alto grado, compatible con un tumor maligno de la vaina nerviosa periférica (TMVNP). Con los datos de anatomía patológica y la cirugía no compartimental sin criterios oncológicos realizada, se procede a remitir a la paciente a nuestro hospital. En ese momento la paciente se encontraba bien, aunque refería rápida reaparición del dolor en el hombro tras la cirugía; en la exploración se aprecia una tumoración fija y gomosa en la escápula derecha. Se apreciaban múltiples neurofibromas múltiples subcutáneos, efélides axilares y manchas cafe-au-lait. Pruebas complementarias » PET-TAC de extensión en febrero de 2014: muestra una masa de partes blandas de 6,2 x 2,8 cm con intenso hipermetabolismo patológico (SUVmáx 20,2 g/ml) que erosiona la escápula derecha, sugestivo de comportamiento agresivo, además se observan múltiples nódulos en la piel, todos ametabólicos, que corresponden a neurofibromas cutáneos. Diagnóstico Expuesto el caso con estos datos en la comisión de tumores, se consideró que la paciente era candidata a tratamiento QT neoadyuvante (para disminuir la extensión de la lesión y con ello la morbilidad de la cirugía) seguida de cirugía con criterios radicales y radioterapia adyuvante. La paciente es incluida en el ensayo clínico GEIS 25 de QT neoadyuvante adaptada al histiotipo (epirrubicina-ifosfamida frente a ifosfamida-VP16 en el caso de TMVNP). La paciente recibe tres ciclos de ifosfamida-VP16 entre marzo y mayo de 2014, con evidente respuesta clínica desde el primer ciclo. La evaluación tras tres ciclos mostró una reducción muy significativa, mayor del 90 % de la tumoración, que se limita prácticamente a la fosa infraespinosa, con zonas avasculares en su interior sugestivas de necrosis, y ausencia de extensión local y a distancia. Vista la excelente respuesta parcial mayor tras la QT, se procede a la planificación de la cirugía con criterios oncológicos por parte del equipo de tumores óseos, realizando escapulectomía subtotal a través del cuello de la escápula manteniendo junto a la pieza extirpada el subescapular, supraespinoso, infraespinoso y redondo menor en junio de 2014. El resultado patológico de la pieza quirúrgica muestra una celularidad mayoritariamente pleomórfica con otras áreas de morfología fusocelular pura y estroma amplio mixoide, zonas de necrosis con células espumosas y células inflamatorias mononucleadas en aproximadamente el 50% del volumen total del tumor. En el estudio inmunohistoquímico las células pleomórficas expresan diferenciación muscular estriada (vimentina + desmina + calponina + miogenina + nuclear, MYOD1 + nuclear). Las fusiformes son focalmente positivas para MyoD1, CD34, y pS100. EMA, beta-catenina, AE1/3, actina. Los bordes de resección estaban libres de tumoración. Todos estos hallazgos eran compatibles con un TMVNP con diferenciación rabdomiosarcomatosa (tumor de tritón). Se complementa el tratamiento con RT externa adyuvante para una dosis total de 66 Gy. Tratamiento QTT neoadyuvante seguida de cirugía con criterios radicales y RT adyuvante. Evolución La paciente inicia seguimiento en nuestras consultas. En enero de 2015, seis meses tras la cirugía radical, se aprecia en la TC un nódulo pulmonar posterobasal derecho que mide aproximadamente 20 mm de diámetro. La PET-TC confirma la presencia de un nódulo redondeado de 26 x 26 x 29 mm hipermetabólico (SUVmáx 5,8 g/ml) en la base del LID, que ha crecido con respecto al estudio TC previa y que no aparecía en el estudio inicial. La paciente permanecía clínicamente asintomática. Dada la presencia de metástasis única con tumor primario controlado, remitimos a la paciente a cirugía torácica para valoración de metastasectomía pulmonar. Se procedió a una cirugía exploradora en febrero de 2015, apreciándose un nódulo de gran tamaño ocupando prácticamente toda la pirámide basal con adenopatías en cisura perivasculares; se practica una lobectomía inferior derecha y una disección ganglionar paratraqueal derecha, localizando además otra adenopatía precava (también resecada). La biopsia confirma la proliferación celular mesenquimal atípica bien delimitada, no encapsulada, formando haces entrecruzados en alternancia con zonas de necrosis y degeneración de aspecto mixoide, además una población celular mayoritaria conformada por elementos fusiformes, sugestiva de TMVNP, aunque no se observa diferenciación rabdomiosarcomatosa. Los bordes quirúrgicos y las adenopatías están libres. Se considera que no hay criterios para tratamiento con QT pseudoadyuvante y la paciente sigue controles en nuestras consultas sin evidencia de enfermedad activa en el momento actual. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Anamnesis Se trata de una mujer de 45 años de edad, como único antecedente patológico destaca una neurofibromatosis tipo 1 diagnosticada en la infancia en forma de neurofibromas múltiples subcutáneos, efélides axilares y manchas cafe-au-lait; no había habido afectación neurológica, ósea ni ocular. Su madre fue diagnosticada de un cáncer de colon a la edad de 67 años, pero no había antecedentes familiares de neurofibromatosis. Exploración física La paciente acudió inicialmente a su Hospital de referencia en Enero de 2013 con clínica de más de un año de evolución consistente en dolor y en la aparición de una tumoración en la escápula derecha. Se realizaron estudios de imagen con ecografía de tejidos blandos donde se apreciaba una masa solida de 45 mm con vascularización y características típicas de neurofibroma y posteriormente una resonancia de escapula derecha que describió una gran masa de 15 cm con necrosis central y signos de vascularización de "características benignas", con lo cual se procedió a realizar una resección marginal en de la lesión en diciembre de 2013. Desgraciadamente, el estudio patológico informó de un sarcoma pleomorfico de alto grado, compatible con un tumor maligno de la vaina nerviosa periférica (TMVNP). Con los datos de anatomía patológica y la cirugía no compartimental sin criterios oncológicos realizada, se procede a remitir a la paciente a nuestro hospital. En ese momento la paciente se encontraba bien, aunque refería rápida reaparición del dolor en el hombro tras la cirugía; en la exploración se aprecia una tumoración fija y gomosa en la escápula derecha. Se apreciaban múltiples neurofibromas múltiples subcutáneos, efélides axilares y manchas cafe-au-lait. Pruebas complementarias » PET-TAC de extensión en febrero de 2014: muestra una masa de partes blandas de 6,2 x 2,8 cm con intenso hipermetabolismo patológico (SUVmáx 20,2 g/ml) que erosiona la escápula derecha, sugestivo de comportamiento agresivo, además se observan múltiples nódulos en la piel, todos ametabólicos, que corresponden a neurofibromas cutáneos. Diagnóstico Expuesto el caso con estos datos en la comisión de tumores, se consideró que la paciente era candidata a tratamiento QT neoadyuvante (para disminuir la extensión de la lesión y con ello la morbilidad de la cirugía) seguida de cirugía con criterios radicales y radioterapia adyuvante. La paciente es incluida en el ensayo clínico GEIS 25 de QT neoadyuvante adaptada al histiotipo (epirrubicina-ifosfamida frente a ifosfamida-VP16 en el caso de TMVNP). La paciente recibe tres ciclos de ifosfamida-VP16 entre marzo y mayo de 2014, con evidente respuesta clínica desde el primer ciclo. La evaluación tras tres ciclos mostró una reducción muy significativa, mayor del 90 % de la tumoración, que se limita prácticamente a la fosa infraespinosa, con zonas avasculares en su interior sugestivas de necrosis, y ausencia de extensión local y a distancia. Vista la excelente respuesta parcial mayor tras la QT, se procede a la planificación de la cirugía con criterios oncológicos por parte del equipo de tumores óseos, realizando escapulectomía subtotal a través del cuello de la escápula manteniendo junto a la pieza extirpada el subescapular, supraespinoso, infraespinoso y redondo menor en junio de 2014. El resultado patológico de la pieza quirúrgica muestra una celularidad mayoritariamente pleomórfica con otras áreas de morfología fusocelular pura y estroma amplio mixoide, zonas de necrosis con células espumosas y células inflamatorias mononucleadas en aproximadamente el 50% del volumen total del tumor. En el estudio inmunohistoquímico las células pleomórficas expresan diferenciación muscular estriada (vimentina + desmina + calponina + miogenina + nuclear, MYOD1 + nuclear). Las fusiformes son focalmente positivas para MyoD1, CD34, y pS100. EMA, beta-catenina, AE1/3, actina. Los bordes de resección estaban libres de tumoración. Todos estos hallazgos eran compatibles con un TMVNP con diferenciación rabdomiosarcomatosa (tumor de tritón). Se complementa el tratamiento con RT externa adyuvante para una dosis total de 66 Gy. Tratamiento QTT neoadyuvante seguida de cirugía con criterios radicales y RT adyuvante. Evolución La paciente inicia seguimiento en nuestras consultas. En enero de 2015, seis meses tras la cirugía radical, se aprecia en la TC un nódulo pulmonar posterobasal derecho que mide aproximadamente 20 mm de diámetro. La PET-TC confirma la presencia de un nódulo redondeado de 26 x 26 x 29 mm hipermetabólico (SUVmáx 5,8 g/ml) en la base del LID, que ha crecido con respecto al estudio TC previa y que no aparecía en el estudio inicial. La paciente permanecía clínicamente asintomática. Dada la presencia de metástasis única con tumor primario controlado, remitimos a la paciente a cirugía torácica para valoración de metastasectomía pulmonar. Se procedió a una cirugía exploradora en febrero de 2015, apreciándose un nódulo de gran tamaño ocupando prácticamente toda la pirámide basal con adenopatías en cisura perivasculares; se practica una lobectomía inferior derecha y una disección ganglionar paratraqueal derecha, localizando además otra adenopatía precava (también resecada). La biopsia confirma la proliferación celular mesenquimal atípica bien delimitada, no encapsulada, formando haces entrecruzados en alternancia con zonas de necrosis y degeneración de aspecto mixoide, además una población celular mayoritaria conformada por elementos fusiformes, sugestiva de TMVNP, aunque no se observa diferenciación rabdomiosarcomatosa. Los bordes quirúrgicos y las adenopatías están libres. Se considera que no hay criterios para tratamiento con QT pseudoadyuvante y la paciente sigue controles en nuestras consultas sin evidencia de enfermedad activa en el momento actual.	[ "Anamnesis", "\n", "Se", "trata", "de", "una", "mujer", "de", "45", "años", "de", "edad", ",", "como", "único", "antecedente", "patológico", "destaca", "una", "neurofibromatosis", "tipo", "1", "diagnosticada", "en", "la", "infancia", "en", "forma", "de", "neurofibromas", "múltiples", "subcutáneos", ",", "efélides", "axilares", "y", "manchas", "cafe", "-", "au", "-", "lait", ";", "no", "había", "habido", "afectación", "neurológica", ",", "ósea", "ni", "ocular", ".", "Su", "madre", "fue", "diagnosticada", "de", "un", "cáncer", "de", "colon", "a", "la", "edad", "de", "67", "años", ",", "pero", "no", "había", "antecedentes", "familiares", "de", "neurofibromatosis", ".", "\n\n", "Exploración", "física", "\n", "La", "paciente", "acudió", "inicialmente", "a", "su", "Hospital", "de", "referencia", "en", "Enero", "de", "2013", "con", "clínica", "de", "más", "de", "un", "año", "de", "evolución", "consistente", "en", "dolor", "y", "en", "la", "aparición", "de", "una", "tumoración", "en", "la", "escápula", "derecha", ".", "Se", "realizaron", "estudios", "de", "imagen", "con", "ecografía", "de", "tejidos", "blandos", "donde", "se", "apreciaba", "una", "masa", "solida", "de", "45", "mm", "con", "vascularización", "y", "características", "típicas", "de", "neurofibroma", "y", "posteriormente", "una", "resonancia", "de", "escapula", "derecha", "que", "describió", "una", "gran", "masa", "de", "15", "cm", "con", "necrosis", "central", "y", "signos", "de", "vascularización", "de", "\"", "características", "benignas", "\"", ",", "con", "lo", "cual", "se", "procedió", "a", "realizar", "una", "resección", "marginal", "en", "de", "la", "lesión", "en", "diciembre", "de", "2013", ".", "Desgraciadamente", ",", "el", "estudio", "patológico", "informó", "de", "un", "sarcoma", "pleomorfico", "de", "alto", "grado", ",", "compatible", "con", "un", "tumor", "maligno", "de", "la", "vaina", "nerviosa", "periférica", "(", "TMVNP", ")", ".", "\n\n", "Con", "los", "datos", "de", "anatomía", "patológica", "y", "la", "cirugía", "no", "compartimental", "sin", "criterios", "oncológicos", "realizada", ",", "se", "procede", "a", "remitir", "a", "la", "paciente", "a", "nuestro", "hospital", ".", "En", "ese", "momento", "la", "paciente", "se", "encontraba", "bien", ",", "aunque", "refería", "rápida", "reaparición", "del", "dolor", "en", "el", "hombro", "tras", "la", "cirugía", ";", "en", "la", "exploración", "se", "aprecia", "una", "tumoración", "fija", "y", "gomosa", "en", "la", "escápula", "derecha", ".", "Se", "apreciaban", "múltiples", "neurofibromas", "múltiples", "subcutáneos", ",", "efélides", "axilares", "y", "manchas", "cafe", "-", "au", "-", "lait", ".", "\n\n", "Pruebas", "complementarias", "\n", "»", "PET", "-", "TAC", "de", "extensión", "en", "febrero", "de", "2014", ":", "muestra", "una", "masa", "de", "partes", "blandas", "de", "6,2", "x", "2,8", "cm", "con", "intenso", "hipermetabolismo", "patológico", "(", "SUVmáx", "20,2", "g", "/", "ml", ")", "que", "erosiona", "la", "escápula", "derecha", ",", "sugestivo", "de", "comportamiento", "agresivo", ",", "además", "se", "observan", "múltiples", "nódulos", "en", "la", "piel", ",", "todos", "ametabólicos", ",", "que", "corresponden", "a", "neurofibromas", "cutáneos", ".", "\n\n", "Diagnóstico", "\n", "Expuesto", "el", "caso", "con", "estos", "datos", "en", "la", "comisión", "de", "tumores", ",", "se", "consideró", "que", "la", "paciente", "era", "candidata", "a", "tratamiento", "QT", "neoadyuvante", "(", "para", "disminuir", "la", "extensión", "de", "la", "lesión", "y", "con", "ello", "la", "morbilidad", "de", "la", "cirugía", ")", "seguida", "de", "cirugía", "con", "criterios", "radicales", "y", "radioterapia", "adyuvante", ".", "\n\n", "La", "paciente", "es", "incluida", "en", "el", "ensayo", "clínico", "GEIS", "25", "de", "QT", "neoadyuvante", "adaptada", "al", "histiotipo", "(", "epirrubicina", "-", "ifosfamida", "frente", "a", "ifosfamida", "-", "VP16", "en", "el", "caso", "de", "TMVNP", ")", ".", "La", "paciente", "recibe", "tres", "ciclos", "de", "ifosfamida", "-", "VP16", "entre", "marzo", "y", "mayo", "de", "2014", ",", "con", "evidente", "respuesta", "clínica", "desde", "el", "primer", "ciclo", ".", "La", "evaluación", "tras", "tres", "ciclos", "mostró", "una", "reducción", "muy", "significativa", ",", "mayor", "del", "90", "%", "de", "la", "tumoración", ",", "que", "se", "limita", "prácticamente", "a", "la", "fosa", "infraespinosa", ",", "con", "zonas", "avasculares", "en", "su", "interior", "sugestivas", "de", "necrosis", ",", "y", "ausencia", "de", "extensión", "local", "y", "a", "distancia", ".", "\n\n", "Vista", "la", "excelente", "respuesta", "parcial", "mayor", "tras", "la", "QT", ",", "se", "procede", "a", "la", "planificación", "de", "la", "cirugía", "con", "criterios", "oncológicos", "por", "parte", "del", "equipo", "de", "tumores", "óseos", ",", "realizando", "escapulectomía", "subtotal", "a", "través", "del", "cuello", "de", "la", "escápula", "manteniendo", "junto", "a", "la", "pieza", "extirpada", "el", "subescapular", ",", "supraespinoso", ",", "infraespinoso", "y", "redondo", "menor", "en", "junio", "de", "2014", ".", "\n\n", "El", "resultado", "patológico", "de", "la", "pieza", "quirúrgica", "muestra", "una", "celularidad", "mayoritariamente", "pleomórfica", "con", "otras", "áreas", "de", "morfología", "fusocelular", "pura", "y", "estroma", "amplio", "mixoide", ",", "zonas", "de", "necrosis", "con", "células", "espumosas", "y", "células", "inflamatorias", "mononucleadas", "en", "aproximadamente", "el", "50", "%", "del", "volumen", "total", "del", "tumor", ".", "En", "el", "estudio", "inmunohistoquímico", "las", "células", "pleomórficas", "expresan", "diferenciación", "muscular", "estriada", "(", "vimentina", "+", "desmina", "+", "calponina", "+", "miogenina", "+", "nuclear", ",", "MYOD1", "+", "nuclear", ")", ".", "Las", "fusiformes", "son", "focalmente", "positivas", "para", "MyoD1", ",", "CD34", ",", "y", "pS100", ".", "EMA", ",", "beta", "-", "catenina", ",", "AE1/3", ",", "actina", ".", "Los", "bordes", "de", "resección", "estaban", "libres", "de", "tumoración", ".", "Todos", "estos", "hallazgos", "eran", "compatibles", "con", "un", "TMVNP", "con", "diferenciación", "rabdomiosarcomatosa", "(", "tumor", "de", "tritón", ")", ".", "\n\n", "Se", "complementa", "el", "tratamiento", "con", "RT", "externa", "adyuvante", "para", "una", "dosis", "total", "de", "66", "Gy", ".", "\n\n", "Tratamiento", "\n", "QTT", "neoadyuvante", "seguida", "de", "cirugía", "con", "criterios", "radicales", "y", "RT", "adyuvante", ".", "\n\n", "Evolución", "\n", "La", "paciente", "inicia", "seguimiento", "en", "nuestras", "consultas", ".", "En", "enero", "de", "2015", ",", "seis", "meses", "tras", "la", "cirugía", "radical", ",", "se", "aprecia", "en", "la", "TC", "un", "nódulo", "pulmonar", "posterobasal", "derecho", "que", "mide", "aproximadamente", "20", "mm", "de", "diámetro", ".", "La", "PET", "-", "TC", "confirma", "la", "presencia", "de", "un", "nódulo", "redondeado", "de", "26", "x", "26", "x", "29", "mm", "hipermetabólico", "(", "SUVmáx", "5,8", "g", "/", "ml", ")", "en", "la", "base", "del", "LID", ",", "que", "ha", "crecido", "con", "respecto", "al", "estudio", "TC", "previa", "y", "que", "no", "aparecía", "en", "el", "estudio", "inicial", ".", "La", "paciente", "permanecía", "clínicamente", "asintomática", ".", "\n\n", "Dada", "la", "presencia", "de", "metástasis", "única", "con", "tumor", "primario", "controlado", ",", "remitimos", "a", "la", "paciente", "a", "cirugía", "torácica", "para", "valoración", "de", "metastasectomía", "pulmonar", ".", "\n\n", "Se", "procedió", "a", "una", "cirugía", "exploradora", "en", "febrero", "de", "2015", ",", "apreciándose", "un", "nódulo", "de", "gran", "tamaño", "ocupando", "prácticamente", "toda", "la", "pirámide", "basal", "con", "adenopatías", "en", "cisura", "perivasculares", ";", "se", "practica", "una", "lobectomía", "inferior", "derecha", "y", "una", "disección", "ganglionar", "paratraqueal", "derecha", ",", "localizando", "además", "otra", "adenopatía", "precava", "(", "también", "resecada", ")", ".", "La", "biopsia", "confirma", "la", "proliferación", "celular", "mesenquimal", "atípica", "bien", "delimitada", ",", "no", "encapsulada", ",", "formando", "haces", "entrecruzados", "en", "alternancia", "con", "zonas", "de", "necrosis", "y", "degeneración", "de", "aspecto", "mixoide", ",", "además", "una", "población", "celular", "mayoritaria", "conformada", "por", "elementos", "fusiformes", ",", "sugestiva", "de", "TMVNP", ",", "aunque", "no", "se", "observa", "diferenciación", "rabdomiosarcomatosa", ".", "Los", "bordes", "quirúrgicos", "y", "las", "adenopatías", "están", "libres", ".", "\n\n", "Se", "considera", "que", "no", "hay", "criterios", "para", "tratamiento", "con", "QT", "pseudoadyuvante", "y", "la", "paciente", "sigue", "controles", "en", "nuestras", "consultas", "sin", "evidencia", "de", "enfermedad", "activa", "en", "el", "momento", "actual", "." ]	[ "MORFOLOGIA_NEOPLASIA" ]
Nitric oxide is a compound, IL-6 is a protein	DS.d1467_task0	Sentence: Nitric oxide (NO) and interlukin-6 (IL-6) are highly reactive mediators that have been shown to play different roles in a variety of different biological process. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein	[ "B-compound", "I-compound", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Nitric oxide (NO) and interlukin-6 (IL-6) are highly reactive mediators that have been shown to play different roles in a variety of different biological process.	[ "Nitric", "oxide", "(", "NO", ")", "and", "interlukin-6", "(", "IL-6", ")", "are", "highly", "reactive", "mediators", "that", "have", "been", "shown", "to", "play", "different", "roles", "in", "a", "variety", "of", "different", "biological", "process", "." ]	[ "compound", "protein" ]
Nitric oxide is a compound, IL-6 is a protein	DS.d1467_task1	Sentence: Nitric oxide (NO) and interlukin-6 (IL-6) are highly reactive mediators that have been shown to play different roles in a variety of different biological process. Instructions: please typing these entity words according to sentence: Nitric oxide, IL-6 Options: compound, protein	[ "B-compound", "I-compound", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Nitric oxide (NO) and interlukin-6 (IL-6) are highly reactive mediators that have been shown to play different roles in a variety of different biological process.	[ "Nitric", "oxide", "(", "NO", ")", "and", "interlukin-6", "(", "IL-6", ")", "are", "highly", "reactive", "mediators", "that", "have", "been", "shown", "to", "play", "different", "roles", "in", "a", "variety", "of", "different", "biological", "process", "." ]	[ "compound", "protein" ]
Nitric oxide, IL-6	DS.d1467_task2	Sentence: Nitric oxide (NO) and interlukin-6 (IL-6) are highly reactive mediators that have been shown to play different roles in a variety of different biological process. Instructions: please extract entity words from the input sentence	[ "B-compound", "I-compound", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Nitric oxide (NO) and interlukin-6 (IL-6) are highly reactive mediators that have been shown to play different roles in a variety of different biological process.	[ "Nitric", "oxide", "(", "NO", ")", "and", "interlukin-6", "(", "IL-6", ")", "are", "highly", "reactive", "mediators", "that", "have", "been", "shown", "to", "play", "different", "roles", "in", "a", "variety", "of", "different", "biological", "process", "." ]	[ "compound", "protein" ]
profilin is a Individual_protein, actin is a Individual_protein	404_task0	Sentence: In Acanthamoeba, the two isoforms of profilin may have specialized functions on the basis of their identical (approximately 10 microM) affinities for actin monomers and different affinities for PIP2. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Individual_protein	[ "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O" ]	In Acanthamoeba, the two isoforms of profilin may have specialized functions on the basis of their identical (approximately 10 microM) affinities for actin monomers and different affinities for PIP2.	[ "In", "Acanthamoeba", ",", "the", "two", "isoforms", "of", "profilin", "may", "have", "specialized", "functions", "on", "the", "basis", "of", "their", "identical", "(", "approximately", "10", "microM", ")", "affinities", "for", "actin", "monomers", "and", "different", "affinities", "for", "PIP2", "." ]	[ "Individual_protein" ]
profilin is a Individual_protein, actin is a Individual_protein	404_task1	Sentence: In Acanthamoeba, the two isoforms of profilin may have specialized functions on the basis of their identical (approximately 10 microM) affinities for actin monomers and different affinities for PIP2. Instructions: please typing these entity words according to sentence: profilin, actin Options: Individual_protein	[ "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O" ]	In Acanthamoeba, the two isoforms of profilin may have specialized functions on the basis of their identical (approximately 10 microM) affinities for actin monomers and different affinities for PIP2.	[ "In", "Acanthamoeba", ",", "the", "two", "isoforms", "of", "profilin", "may", "have", "specialized", "functions", "on", "the", "basis", "of", "their", "identical", "(", "approximately", "10", "microM", ")", "affinities", "for", "actin", "monomers", "and", "different", "affinities", "for", "PIP2", "." ]	[ "Individual_protein" ]
profilin, actin	404_task2	Sentence: In Acanthamoeba, the two isoforms of profilin may have specialized functions on the basis of their identical (approximately 10 microM) affinities for actin monomers and different affinities for PIP2. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O" ]	In Acanthamoeba, the two isoforms of profilin may have specialized functions on the basis of their identical (approximately 10 microM) affinities for actin monomers and different affinities for PIP2.	[ "In", "Acanthamoeba", ",", "the", "two", "isoforms", "of", "profilin", "may", "have", "specialized", "functions", "on", "the", "basis", "of", "their", "identical", "(", "approximately", "10", "microM", ")", "affinities", "for", "actin", "monomers", "and", "different", "affinities", "for", "PIP2", "." ]	[ "Individual_protein" ]
temozolomide is a compound, Fas is a protein	DS.d421_task0	Sentence: This additive effect was not observed when glioma cells were pre-treated with temozolomide, which was unable to increase Fas expression in tumor. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O" ]	This additive effect was not observed when glioma cells were pre-treated with temozolomide, which was unable to increase Fas expression in tumor.	[ "This", "additive", "effect", "was", "not", "observed", "when", "glioma", "cells", "were", "pre", "-", "treated", "with", "temozolomide", ",", "which", "was", "unable", "to", "increase", "Fas", "expression", "in", "tumor", "." ]	[ "compound", "protein" ]
temozolomide is a compound, Fas is a protein	DS.d421_task1	Sentence: This additive effect was not observed when glioma cells were pre-treated with temozolomide, which was unable to increase Fas expression in tumor. Instructions: please typing these entity words according to sentence: temozolomide, Fas Options: compound, protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O" ]	This additive effect was not observed when glioma cells were pre-treated with temozolomide, which was unable to increase Fas expression in tumor.	[ "This", "additive", "effect", "was", "not", "observed", "when", "glioma", "cells", "were", "pre", "-", "treated", "with", "temozolomide", ",", "which", "was", "unable", "to", "increase", "Fas", "expression", "in", "tumor", "." ]	[ "compound", "protein" ]
temozolomide, Fas	DS.d421_task2	Sentence: This additive effect was not observed when glioma cells were pre-treated with temozolomide, which was unable to increase Fas expression in tumor. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O" ]	This additive effect was not observed when glioma cells were pre-treated with temozolomide, which was unable to increase Fas expression in tumor.	[ "This", "additive", "effect", "was", "not", "observed", "when", "glioma", "cells", "were", "pre", "-", "treated", "with", "temozolomide", ",", "which", "was", "unable", "to", "increase", "Fas", "expression", "in", "tumor", "." ]	[ "compound", "protein" ]
Kindes- is an umlsterm, Jugendlichenalter is an umlsterm, -Syndrom is an umlsterm, supraventrikulaere Tachykardien is an umlsterm, Synkope is an umlsterm, Herz - Kreislauf - Stillstand is an umlsterm, Reanimation is an umlsterm	MonatsschriftKinderheilkunde.71450020.ger.abstr_task0	Sentence: Im Kindes- und Jugendlichenalter manifestiert sich das Wolff-Parkinson-White ( WPW ) -Syndrom fast ausschliesslich durch paroxysmale supraventrikulaere Tachykardien . Ursache einer Synkope bei einem 15 Jahre alten , zuvor voellig asymptomatischen Jugendlichen war ein durch Kammerflattern bedingter Herz-Kreislauf-Stillstand . Nach erfolgreicher Reanimation zeigte sich im Elektrokardiogramm ein klassisches Praeexzitationsmuster . Bei der elektrophysiologischen Untersuchung fand sich eine linksposterior lokalisierte akzessorische Leitungsbahn , die dann durch Hochfrequenzapplikation erfolgreich abladiert wurde . Seither ist der Junge beschwerdefrei . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Im Kindes- und Jugendlichenalter manifestiert sich das Wolff-Parkinson-White ( WPW ) -Syndrom fast ausschliesslich durch paroxysmale supraventrikulaere Tachykardien . Ursache einer Synkope bei einem 15 Jahre alten , zuvor voellig asymptomatischen Jugendlichen war ein durch Kammerflattern bedingter Herz-Kreislauf-Stillstand . Nach erfolgreicher Reanimation zeigte sich im Elektrokardiogramm ein klassisches Praeexzitationsmuster . Bei der elektrophysiologischen Untersuchung fand sich eine linksposterior lokalisierte akzessorische Leitungsbahn , die dann durch Hochfrequenzapplikation erfolgreich abladiert wurde . Seither ist der Junge beschwerdefrei .	[ "Im", "Kindes-", "und", "Jugendlichenalter", "manifestiert", "sich", "das", "Wolff", "-", "Parkinson", "-", "White", "(", "WPW", ")", "-Syndrom", "fast", "ausschliesslich", "durch", "paroxysmale", "supraventrikulaere", "Tachykardien", ".", "Ursache", "einer", "Synkope", "bei", "einem", "15", "Jahre", "alten", ",", "zuvor", "voellig", "asymptomatischen", "Jugendlichen", "war", "ein", "durch", "Kammerflattern", "bedingter", "Herz", "-", "Kreislauf", "-", "Stillstand", ".", "Nach", "erfolgreicher", "Reanimation", "zeigte", "sich", "im", "Elektrokardiogramm", "ein", "klassisches", "Praeexzitationsmuster", ".", "Bei", "der", "elektrophysiologischen", "Untersuchung", "fand", "sich", "eine", "linksposterior", "lokalisierte", "akzessorische", "Leitungsbahn", ",", "die", "dann", "durch", "Hochfrequenzapplikation", "erfolgreich", "abladiert", "wurde", ".", "Seither", "ist", "der", "Junge", "beschwerdefrei", "." ]	[ "umlsterm" ]

Skelettdysplasien is an umlsterm, Sklerose is an umlsterm, Schaedels is an umlsterm, Diagnosestellung is an umlsterm, maennliches is an umlsterm, Kleinkind is an umlsterm, Hypertelorismus is an umlsterm, Zahnirregularitaeten is an umlsterm, Mutter is an umlsterm, Patienten is an umlsterm, Stigmata is an umlsterm, Roentgenaufnahmen is an umlsterm, Schaedel is an umlsterm, Femur is an umlsterm, Patient is an umlsterm, Mutter is an umlsterm, Diagnose is an umlsterm, Knochenstoffwechsels is an umlsterm, Kindes is an umlsterm, Osteoblasten is an umlsterm, Hirnnervenkompression is an umlsterm, Komplikation is an umlsterm, Vomer is an umlsterm, Diagnosestellung is an umlsterm, Komplikationen is an umlsterm

MonatsschriftKinderheilkunde.61441073.ger.abstr_task0

Sentence: Die kraniometaphysaere Dysplasie stellt eine seltene Unterform der sklerosierenden Skelettdysplasien mit klinischer Manifestation im fruehen Kleinkindesalter dar , die mit einer deutlichen Sklerose des gesamten Schaedels und mit einer Aufweitung der Metaphysen der langen Roehrenknochen einhergeht . Wir berichten ueber ein zum Zeitpunkt der Diagnosestellung 18 Monate altes maennliches Kleinkind , das mit zunehmendem Makrozephalus , chronischer Nasenatmungsbehinderung und einer Gesichtsdysmorphie ( Hypertelorismus , breite Nasenwurzel , Zahnirregularitaeten ) auffaellig wurde . Die Mutter des Patienten wies aehnliche Stigmata auf . Durch Roentgenaufnahmen von Schaedel und Femur bei Patient und Mutter konnte die Diagnose gestellt werden . Untersuchungen des Knochenstoffwechsels des betroffenen Kindes weisen auf eine Ueberaktivitaet der Osteoblasten hin . Eine Hirnnervenkompression als typische Komplikation des Krankheitsbilds konnte ausgeschlossen werden . Die krankheitsbedingte Nasenatmungsbehinderung machte jedoch eine Choanalerweiterung durch Resektion des posterioren Vomer notwendig . Die Kenntnis dieses Krankheitsbilds erlaubt eine rechtzeitige Diagnosestellung und Intervention bei Komplikationen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O" ]

Die kraniometaphysaere Dysplasie stellt eine seltene Unterform der sklerosierenden Skelettdysplasien mit klinischer Manifestation im fruehen Kleinkindesalter dar , die mit einer deutlichen Sklerose des gesamten Schaedels und mit einer Aufweitung der Metaphysen der langen Roehrenknochen einhergeht . Wir berichten ueber ein zum Zeitpunkt der Diagnosestellung 18 Monate altes maennliches Kleinkind , das mit zunehmendem Makrozephalus , chronischer Nasenatmungsbehinderung und einer Gesichtsdysmorphie ( Hypertelorismus , breite Nasenwurzel , Zahnirregularitaeten ) auffaellig wurde . Die Mutter des Patienten wies aehnliche Stigmata auf . Durch Roentgenaufnahmen von Schaedel und Femur bei Patient und Mutter konnte die Diagnose gestellt werden . Untersuchungen des Knochenstoffwechsels des betroffenen Kindes weisen auf eine Ueberaktivitaet der Osteoblasten hin . Eine Hirnnervenkompression als typische Komplikation des Krankheitsbilds konnte ausgeschlossen werden . Die krankheitsbedingte Nasenatmungsbehinderung machte jedoch eine Choanalerweiterung durch Resektion des posterioren Vomer notwendig . Die Kenntnis dieses Krankheitsbilds erlaubt eine rechtzeitige Diagnosestellung und Intervention bei Komplikationen .

[ "Die", "kraniometaphysaere", "Dysplasie", "stellt", "eine", "seltene", "Unterform", "der", "sklerosierenden", "Skelettdysplasien", "mit", "klinischer", "Manifestation", "im", "fruehen", "Kleinkindesalter", "dar", ",", "die", "mit", "einer", "deutlichen", "Sklerose", "des", "gesamten", "Schaedels", "und", "mit", "einer", "Aufweitung", "der", "Metaphysen", "der", "langen", "Roehrenknochen", "einhergeht", ".", "Wir", "berichten", "ueber", "ein", "zum", "Zeitpunkt", "der", "Diagnosestellung", "18", "Monate", "altes", "maennliches", "Kleinkind", ",", "das", "mit", "zunehmendem", "Makrozephalus", ",", "chronischer", "Nasenatmungsbehinderung", "und", "einer", "Gesichtsdysmorphie", "(", "Hypertelorismus", ",", "breite", "Nasenwurzel", ",", "Zahnirregularitaeten", ")", "auffaellig", "wurde", ".", "Die", "Mutter", "des", "Patienten", "wies", "aehnliche", "Stigmata", "auf", ".", "Durch", "Roentgenaufnahmen", "von", "Schaedel", "und", "Femur", "bei", "Patient", "und", "Mutter", "konnte", "die", "Diagnose", "gestellt", "werden", ".", "Untersuchungen", "des", "Knochenstoffwechsels", "des", "betroffenen", "Kindes", "weisen", "auf", "eine", "Ueberaktivitaet", "der", "Osteoblasten", "hin", ".", "Eine", "Hirnnervenkompression", "als", "typische", "Komplikation", "des", "Krankheitsbilds", "konnte", "ausgeschlossen", "werden", ".", "Die", "krankheitsbedingte", "Nasenatmungsbehinderung", "machte", "jedoch", "eine", "Choanalerweiterung", "durch", "Resektion", "des", "posterioren", "Vomer", "notwendig", ".", "Die", "Kenntnis", "dieses", "Krankheitsbilds", "erlaubt", "eine", "rechtzeitige", "Diagnosestellung", "und", "Intervention", "bei", "Komplikationen", "." ]

[ "umlsterm" ]

Skelettdysplasien is an umlsterm, Sklerose is an umlsterm, Schaedels is an umlsterm, Diagnosestellung is an umlsterm, maennliches is an umlsterm, Kleinkind is an umlsterm, Hypertelorismus is an umlsterm, Zahnirregularitaeten is an umlsterm, Mutter is an umlsterm, Patienten is an umlsterm, Stigmata is an umlsterm, Roentgenaufnahmen is an umlsterm, Schaedel is an umlsterm, Femur is an umlsterm, Patient is an umlsterm, Mutter is an umlsterm, Diagnose is an umlsterm, Knochenstoffwechsels is an umlsterm, Kindes is an umlsterm, Osteoblasten is an umlsterm, Hirnnervenkompression is an umlsterm, Komplikation is an umlsterm, Vomer is an umlsterm, Diagnosestellung is an umlsterm, Komplikationen is an umlsterm

MonatsschriftKinderheilkunde.61441073.ger.abstr_task1

Sentence: Die kraniometaphysaere Dysplasie stellt eine seltene Unterform der sklerosierenden Skelettdysplasien mit klinischer Manifestation im fruehen Kleinkindesalter dar , die mit einer deutlichen Sklerose des gesamten Schaedels und mit einer Aufweitung der Metaphysen der langen Roehrenknochen einhergeht . Wir berichten ueber ein zum Zeitpunkt der Diagnosestellung 18 Monate altes maennliches Kleinkind , das mit zunehmendem Makrozephalus , chronischer Nasenatmungsbehinderung und einer Gesichtsdysmorphie ( Hypertelorismus , breite Nasenwurzel , Zahnirregularitaeten ) auffaellig wurde . Die Mutter des Patienten wies aehnliche Stigmata auf . Durch Roentgenaufnahmen von Schaedel und Femur bei Patient und Mutter konnte die Diagnose gestellt werden . Untersuchungen des Knochenstoffwechsels des betroffenen Kindes weisen auf eine Ueberaktivitaet der Osteoblasten hin . Eine Hirnnervenkompression als typische Komplikation des Krankheitsbilds konnte ausgeschlossen werden . Die krankheitsbedingte Nasenatmungsbehinderung machte jedoch eine Choanalerweiterung durch Resektion des posterioren Vomer notwendig . Die Kenntnis dieses Krankheitsbilds erlaubt eine rechtzeitige Diagnosestellung und Intervention bei Komplikationen . Instructions: please typing these entity words according to sentence: Skelettdysplasien, Sklerose, Schaedels, Diagnosestellung, maennliches, Kleinkind, Hypertelorismus, Zahnirregularitaeten, Mutter, Patienten, Stigmata, Roentgenaufnahmen, Schaedel, Femur, Patient, Mutter, Diagnose, Knochenstoffwechsels, Kindes, Osteoblasten, Hirnnervenkompression, Komplikation, Vomer, Diagnosestellung, Komplikationen Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O" ]

Die kraniometaphysaere Dysplasie stellt eine seltene Unterform der sklerosierenden Skelettdysplasien mit klinischer Manifestation im fruehen Kleinkindesalter dar , die mit einer deutlichen Sklerose des gesamten Schaedels und mit einer Aufweitung der Metaphysen der langen Roehrenknochen einhergeht . Wir berichten ueber ein zum Zeitpunkt der Diagnosestellung 18 Monate altes maennliches Kleinkind , das mit zunehmendem Makrozephalus , chronischer Nasenatmungsbehinderung und einer Gesichtsdysmorphie ( Hypertelorismus , breite Nasenwurzel , Zahnirregularitaeten ) auffaellig wurde . Die Mutter des Patienten wies aehnliche Stigmata auf . Durch Roentgenaufnahmen von Schaedel und Femur bei Patient und Mutter konnte die Diagnose gestellt werden . Untersuchungen des Knochenstoffwechsels des betroffenen Kindes weisen auf eine Ueberaktivitaet der Osteoblasten hin . Eine Hirnnervenkompression als typische Komplikation des Krankheitsbilds konnte ausgeschlossen werden . Die krankheitsbedingte Nasenatmungsbehinderung machte jedoch eine Choanalerweiterung durch Resektion des posterioren Vomer notwendig . Die Kenntnis dieses Krankheitsbilds erlaubt eine rechtzeitige Diagnosestellung und Intervention bei Komplikationen .

[ "Die", "kraniometaphysaere", "Dysplasie", "stellt", "eine", "seltene", "Unterform", "der", "sklerosierenden", "Skelettdysplasien", "mit", "klinischer", "Manifestation", "im", "fruehen", "Kleinkindesalter", "dar", ",", "die", "mit", "einer", "deutlichen", "Sklerose", "des", "gesamten", "Schaedels", "und", "mit", "einer", "Aufweitung", "der", "Metaphysen", "der", "langen", "Roehrenknochen", "einhergeht", ".", "Wir", "berichten", "ueber", "ein", "zum", "Zeitpunkt", "der", "Diagnosestellung", "18", "Monate", "altes", "maennliches", "Kleinkind", ",", "das", "mit", "zunehmendem", "Makrozephalus", ",", "chronischer", "Nasenatmungsbehinderung", "und", "einer", "Gesichtsdysmorphie", "(", "Hypertelorismus", ",", "breite", "Nasenwurzel", ",", "Zahnirregularitaeten", ")", "auffaellig", "wurde", ".", "Die", "Mutter", "des", "Patienten", "wies", "aehnliche", "Stigmata", "auf", ".", "Durch", "Roentgenaufnahmen", "von", "Schaedel", "und", "Femur", "bei", "Patient", "und", "Mutter", "konnte", "die", "Diagnose", "gestellt", "werden", ".", "Untersuchungen", "des", "Knochenstoffwechsels", "des", "betroffenen", "Kindes", "weisen", "auf", "eine", "Ueberaktivitaet", "der", "Osteoblasten", "hin", ".", "Eine", "Hirnnervenkompression", "als", "typische", "Komplikation", "des", "Krankheitsbilds", "konnte", "ausgeschlossen", "werden", ".", "Die", "krankheitsbedingte", "Nasenatmungsbehinderung", "machte", "jedoch", "eine", "Choanalerweiterung", "durch", "Resektion", "des", "posterioren", "Vomer", "notwendig", ".", "Die", "Kenntnis", "dieses", "Krankheitsbilds", "erlaubt", "eine", "rechtzeitige", "Diagnosestellung", "und", "Intervention", "bei", "Komplikationen", "." ]

[ "umlsterm" ]

Skelettdysplasien, Sklerose, Schaedels, Diagnosestellung, maennliches, Kleinkind, Hypertelorismus, Zahnirregularitaeten, Mutter, Patienten, Stigmata, Roentgenaufnahmen, Schaedel, Femur, Patient, Mutter, Diagnose, Knochenstoffwechsels, Kindes, Osteoblasten, Hirnnervenkompression, Komplikation, Vomer, Diagnosestellung, Komplikationen

MonatsschriftKinderheilkunde.61441073.ger.abstr_task2

Sentence: Die kraniometaphysaere Dysplasie stellt eine seltene Unterform der sklerosierenden Skelettdysplasien mit klinischer Manifestation im fruehen Kleinkindesalter dar , die mit einer deutlichen Sklerose des gesamten Schaedels und mit einer Aufweitung der Metaphysen der langen Roehrenknochen einhergeht . Wir berichten ueber ein zum Zeitpunkt der Diagnosestellung 18 Monate altes maennliches Kleinkind , das mit zunehmendem Makrozephalus , chronischer Nasenatmungsbehinderung und einer Gesichtsdysmorphie ( Hypertelorismus , breite Nasenwurzel , Zahnirregularitaeten ) auffaellig wurde . Die Mutter des Patienten wies aehnliche Stigmata auf . Durch Roentgenaufnahmen von Schaedel und Femur bei Patient und Mutter konnte die Diagnose gestellt werden . Untersuchungen des Knochenstoffwechsels des betroffenen Kindes weisen auf eine Ueberaktivitaet der Osteoblasten hin . Eine Hirnnervenkompression als typische Komplikation des Krankheitsbilds konnte ausgeschlossen werden . Die krankheitsbedingte Nasenatmungsbehinderung machte jedoch eine Choanalerweiterung durch Resektion des posterioren Vomer notwendig . Die Kenntnis dieses Krankheitsbilds erlaubt eine rechtzeitige Diagnosestellung und Intervention bei Komplikationen . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O" ]

Die kraniometaphysaere Dysplasie stellt eine seltene Unterform der sklerosierenden Skelettdysplasien mit klinischer Manifestation im fruehen Kleinkindesalter dar , die mit einer deutlichen Sklerose des gesamten Schaedels und mit einer Aufweitung der Metaphysen der langen Roehrenknochen einhergeht . Wir berichten ueber ein zum Zeitpunkt der Diagnosestellung 18 Monate altes maennliches Kleinkind , das mit zunehmendem Makrozephalus , chronischer Nasenatmungsbehinderung und einer Gesichtsdysmorphie ( Hypertelorismus , breite Nasenwurzel , Zahnirregularitaeten ) auffaellig wurde . Die Mutter des Patienten wies aehnliche Stigmata auf . Durch Roentgenaufnahmen von Schaedel und Femur bei Patient und Mutter konnte die Diagnose gestellt werden . Untersuchungen des Knochenstoffwechsels des betroffenen Kindes weisen auf eine Ueberaktivitaet der Osteoblasten hin . Eine Hirnnervenkompression als typische Komplikation des Krankheitsbilds konnte ausgeschlossen werden . Die krankheitsbedingte Nasenatmungsbehinderung machte jedoch eine Choanalerweiterung durch Resektion des posterioren Vomer notwendig . Die Kenntnis dieses Krankheitsbilds erlaubt eine rechtzeitige Diagnosestellung und Intervention bei Komplikationen .

[ "Die", "kraniometaphysaere", "Dysplasie", "stellt", "eine", "seltene", "Unterform", "der", "sklerosierenden", "Skelettdysplasien", "mit", "klinischer", "Manifestation", "im", "fruehen", "Kleinkindesalter", "dar", ",", "die", "mit", "einer", "deutlichen", "Sklerose", "des", "gesamten", "Schaedels", "und", "mit", "einer", "Aufweitung", "der", "Metaphysen", "der", "langen", "Roehrenknochen", "einhergeht", ".", "Wir", "berichten", "ueber", "ein", "zum", "Zeitpunkt", "der", "Diagnosestellung", "18", "Monate", "altes", "maennliches", "Kleinkind", ",", "das", "mit", "zunehmendem", "Makrozephalus", ",", "chronischer", "Nasenatmungsbehinderung", "und", "einer", "Gesichtsdysmorphie", "(", "Hypertelorismus", ",", "breite", "Nasenwurzel", ",", "Zahnirregularitaeten", ")", "auffaellig", "wurde", ".", "Die", "Mutter", "des", "Patienten", "wies", "aehnliche", "Stigmata", "auf", ".", "Durch", "Roentgenaufnahmen", "von", "Schaedel", "und", "Femur", "bei", "Patient", "und", "Mutter", "konnte", "die", "Diagnose", "gestellt", "werden", ".", "Untersuchungen", "des", "Knochenstoffwechsels", "des", "betroffenen", "Kindes", "weisen", "auf", "eine", "Ueberaktivitaet", "der", "Osteoblasten", "hin", ".", "Eine", "Hirnnervenkompression", "als", "typische", "Komplikation", "des", "Krankheitsbilds", "konnte", "ausgeschlossen", "werden", ".", "Die", "krankheitsbedingte", "Nasenatmungsbehinderung", "machte", "jedoch", "eine", "Choanalerweiterung", "durch", "Resektion", "des", "posterioren", "Vomer", "notwendig", ".", "Die", "Kenntnis", "dieses", "Krankheitsbilds", "erlaubt", "eine", "rechtzeitige", "Diagnosestellung", "und", "Intervention", "bei", "Komplikationen", "." ]

[ "umlsterm" ]

assay is an umlsterm, glucose is an umlsterm, ketones is an umlsterm, in urine is an umlsterm, test is an umlsterm, ketones is an umlsterm, autopsy is an umlsterm, hypothermia is an umlsterm, glucose is an umlsterm, urine is an umlsterm, urine is an umlsterm, acetone is an umlsterm, concentrations is an umlsterm, gas chromatography is an umlsterm, test is an umlsterm, ketones is an umlsterm, glucose is an umlsterm, in urine is an umlsterm, diagnosis is an umlsterm, death is an umlsterm, hyperthermia is an umlsterm

Rechtsmedizin.80080186.eng.abstr_task0

Sentence: The Keto-Diabur-Test 5000 ( Boehringer Mannheim ) is an assay for glucose and ketones in urine samples . Positive test results for ketones were obtained during the autopsy of three corpses who probably died following hypothermia , whereas the glucose levels in the urine samples were normal . In all of the three urine samples extremely high acetone concentrations of 140 , 1004 and 2703 mg/L were detected by headspace gas chromatography . A positive test for ketones using the Keto-Diabur-Test 5000 despite of normal glucose levels in urine can support the diagnosis of death due to hyperthermia . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]

The Keto-Diabur-Test 5000 ( Boehringer Mannheim ) is an assay for glucose and ketones in urine samples . Positive test results for ketones were obtained during the autopsy of three corpses who probably died following hypothermia , whereas the glucose levels in the urine samples were normal . In all of the three urine samples extremely high acetone concentrations of 140 , 1004 and 2703 mg/L were detected by headspace gas chromatography . A positive test for ketones using the Keto-Diabur-Test 5000 despite of normal glucose levels in urine can support the diagnosis of death due to hyperthermia .

[ "The", "Keto", "-", "Diabur", "-", "Test", "5000", "(", "Boehringer", "Mannheim", ")", "is", "an", "assay", "for", "glucose", "and", "ketones", "in", "urine", "samples", ".", "Positive", "test", "results", "for", "ketones", "were", "obtained", "during", "the", "autopsy", "of", "three", "corpses", "who", "probably", "died", "following", "hypothermia", ",", "whereas", "the", "glucose", "levels", "in", "the", "urine", "samples", "were", "normal", ".", "In", "all", "of", "the", "three", "urine", "samples", "extremely", "high", "acetone", "concentrations", "of", "140", ",", "1004", "and", "2703", "mg", "/", "L", "were", "detected", "by", "headspace", "gas", "chromatography", ".", "A", "positive", "test", "for", "ketones", "using", "the", "Keto", "-", "Diabur", "-", "Test", "5000", "despite", "of", "normal", "glucose", "levels", "in", "urine", "can", "support", "the", "diagnosis", "of", "death", "due", "to", "hyperthermia", "." ]

[ "umlsterm" ]

assay is an umlsterm, glucose is an umlsterm, ketones is an umlsterm, in urine is an umlsterm, test is an umlsterm, ketones is an umlsterm, autopsy is an umlsterm, hypothermia is an umlsterm, glucose is an umlsterm, urine is an umlsterm, urine is an umlsterm, acetone is an umlsterm, concentrations is an umlsterm, gas chromatography is an umlsterm, test is an umlsterm, ketones is an umlsterm, glucose is an umlsterm, in urine is an umlsterm, diagnosis is an umlsterm, death is an umlsterm, hyperthermia is an umlsterm

Rechtsmedizin.80080186.eng.abstr_task1

Sentence: The Keto-Diabur-Test 5000 ( Boehringer Mannheim ) is an assay for glucose and ketones in urine samples . Positive test results for ketones were obtained during the autopsy of three corpses who probably died following hypothermia , whereas the glucose levels in the urine samples were normal . In all of the three urine samples extremely high acetone concentrations of 140 , 1004 and 2703 mg/L were detected by headspace gas chromatography . A positive test for ketones using the Keto-Diabur-Test 5000 despite of normal glucose levels in urine can support the diagnosis of death due to hyperthermia . Instructions: please typing these entity words according to sentence: assay, glucose, ketones, in urine, test, ketones, autopsy, hypothermia, glucose, urine, urine, acetone, concentrations, gas chromatography, test, ketones, glucose, in urine, diagnosis, death, hyperthermia Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]

The Keto-Diabur-Test 5000 ( Boehringer Mannheim ) is an assay for glucose and ketones in urine samples . Positive test results for ketones were obtained during the autopsy of three corpses who probably died following hypothermia , whereas the glucose levels in the urine samples were normal . In all of the three urine samples extremely high acetone concentrations of 140 , 1004 and 2703 mg/L were detected by headspace gas chromatography . A positive test for ketones using the Keto-Diabur-Test 5000 despite of normal glucose levels in urine can support the diagnosis of death due to hyperthermia .

[ "The", "Keto", "-", "Diabur", "-", "Test", "5000", "(", "Boehringer", "Mannheim", ")", "is", "an", "assay", "for", "glucose", "and", "ketones", "in", "urine", "samples", ".", "Positive", "test", "results", "for", "ketones", "were", "obtained", "during", "the", "autopsy", "of", "three", "corpses", "who", "probably", "died", "following", "hypothermia", ",", "whereas", "the", "glucose", "levels", "in", "the", "urine", "samples", "were", "normal", ".", "In", "all", "of", "the", "three", "urine", "samples", "extremely", "high", "acetone", "concentrations", "of", "140", ",", "1004", "and", "2703", "mg", "/", "L", "were", "detected", "by", "headspace", "gas", "chromatography", ".", "A", "positive", "test", "for", "ketones", "using", "the", "Keto", "-", "Diabur", "-", "Test", "5000", "despite", "of", "normal", "glucose", "levels", "in", "urine", "can", "support", "the", "diagnosis", "of", "death", "due", "to", "hyperthermia", "." ]

[ "umlsterm" ]

assay, glucose, ketones, in urine, test, ketones, autopsy, hypothermia, glucose, urine, urine, acetone, concentrations, gas chromatography, test, ketones, glucose, in urine, diagnosis, death, hyperthermia

Rechtsmedizin.80080186.eng.abstr_task2

Sentence: The Keto-Diabur-Test 5000 ( Boehringer Mannheim ) is an assay for glucose and ketones in urine samples . Positive test results for ketones were obtained during the autopsy of three corpses who probably died following hypothermia , whereas the glucose levels in the urine samples were normal . In all of the three urine samples extremely high acetone concentrations of 140 , 1004 and 2703 mg/L were detected by headspace gas chromatography . A positive test for ketones using the Keto-Diabur-Test 5000 despite of normal glucose levels in urine can support the diagnosis of death due to hyperthermia . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]

The Keto-Diabur-Test 5000 ( Boehringer Mannheim ) is an assay for glucose and ketones in urine samples . Positive test results for ketones were obtained during the autopsy of three corpses who probably died following hypothermia , whereas the glucose levels in the urine samples were normal . In all of the three urine samples extremely high acetone concentrations of 140 , 1004 and 2703 mg/L were detected by headspace gas chromatography . A positive test for ketones using the Keto-Diabur-Test 5000 despite of normal glucose levels in urine can support the diagnosis of death due to hyperthermia .

[ "The", "Keto", "-", "Diabur", "-", "Test", "5000", "(", "Boehringer", "Mannheim", ")", "is", "an", "assay", "for", "glucose", "and", "ketones", "in", "urine", "samples", ".", "Positive", "test", "results", "for", "ketones", "were", "obtained", "during", "the", "autopsy", "of", "three", "corpses", "who", "probably", "died", "following", "hypothermia", ",", "whereas", "the", "glucose", "levels", "in", "the", "urine", "samples", "were", "normal", ".", "In", "all", "of", "the", "three", "urine", "samples", "extremely", "high", "acetone", "concentrations", "of", "140", ",", "1004", "and", "2703", "mg", "/", "L", "were", "detected", "by", "headspace", "gas", "chromatography", ".", "A", "positive", "test", "for", "ketones", "using", "the", "Keto", "-", "Diabur", "-", "Test", "5000", "despite", "of", "normal", "glucose", "levels", "in", "urine", "can", "support", "the", "diagnosis", "of", "death", "due", "to", "hyperthermia", "." ]

[ "umlsterm" ]

Purpura fulminans is an umlsterm, emergency is an umlsterm, internal medicine is an umlsterm, dermatology is an umlsterm, development is an umlsterm, skin is an umlsterm, necrosis is an umlsterm, disseminated intravascular coagulation is an umlsterm, consumption is an umlsterm, anticoagulant is an umlsterm, signs is an umlsterm, shock is an umlsterm, Purpura fulminans is an umlsterm, form is an umlsterm, protein C deficiency is an umlsterm, causes is an umlsterm, ecchymosis is an umlsterm, blebs is an umlsterm, necrosis is an umlsterm, erythrocytes is an umlsterm, thrombosis is an umlsterm, vessels is an umlsterm, Thrombocytopenia is an umlsterm, coagulation factors is an umlsterm, fibrinogen split products is an umlsterm, erythrocytes is an umlsterm, blood is an umlsterm, diagnosis is an umlsterm, therapy is an umlsterm, plasma is an umlsterm, heparin is an umlsterm, antibiotics is an umlsterm, surgical is an umlsterm, debridement is an umlsterm, disease is an umlsterm, mortality rate is an umlsterm, life is an umlsterm, patient is an umlsterm

DerHautarzt.60470541.eng.abstr_task0

Sentence: Purpura fulminans must be treated as an emergency in internal medicine and dermatology . Its characteristic features are the sudden development of progressively enlarging haemorrhagic skin necrosis , severe disseminated intravascular coagulation with consumption of anticoagulant factors , and signs of shock . Purpura fulminans can be classified into a neonatal form with inherited protein C deficiency and an acquired type for which multiple causes are known . Clinically it is characterized by massive ecchymosis with haemorrhagic blebs and acral necrosis . Histologically the lesions show widespread extravasation of erythrocytes and thrombosis of small vessels . Thrombocytopenia , decrease of coagulation factors , the presence of fibrinogen split products and fragmented erythrocytes in the blood smear help to confirm the diagnosis . The therapy includes fresh-frozen plasma , heparin , antibiotics and surgical debridement of necrotic areas . It is important to recognize the disease promptly because the mortality rate is about 30-40% and only quick intervention helps to save the life of the patient . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]

Purpura fulminans must be treated as an emergency in internal medicine and dermatology . Its characteristic features are the sudden development of progressively enlarging haemorrhagic skin necrosis , severe disseminated intravascular coagulation with consumption of anticoagulant factors , and signs of shock . Purpura fulminans can be classified into a neonatal form with inherited protein C deficiency and an acquired type for which multiple causes are known . Clinically it is characterized by massive ecchymosis with haemorrhagic blebs and acral necrosis . Histologically the lesions show widespread extravasation of erythrocytes and thrombosis of small vessels . Thrombocytopenia , decrease of coagulation factors , the presence of fibrinogen split products and fragmented erythrocytes in the blood smear help to confirm the diagnosis . The therapy includes fresh-frozen plasma , heparin , antibiotics and surgical debridement of necrotic areas . It is important to recognize the disease promptly because the mortality rate is about 30-40% and only quick intervention helps to save the life of the patient .

[ "Purpura", "fulminans", "must", "be", "treated", "as", "an", "emergency", "in", "internal", "medicine", "and", "dermatology", ".", "Its", "characteristic", "features", "are", "the", "sudden", "development", "of", "progressively", "enlarging", "haemorrhagic", "skin", "necrosis", ",", "severe", "disseminated", "intravascular", "coagulation", "with", "consumption", "of", "anticoagulant", "factors", ",", "and", "signs", "of", "shock", ".", "Purpura", "fulminans", "can", "be", "classified", "into", "a", "neonatal", "form", "with", "inherited", "protein", "C", "deficiency", "and", "an", "acquired", "type", "for", "which", "multiple", "causes", "are", "known", ".", "Clinically", "it", "is", "characterized", "by", "massive", "ecchymosis", "with", "haemorrhagic", "blebs", "and", "acral", "necrosis", ".", "Histologically", "the", "lesions", "show", "widespread", "extravasation", "of", "erythrocytes", "and", "thrombosis", "of", "small", "vessels", ".", "Thrombocytopenia", ",", "decrease", "of", "coagulation", "factors", ",", "the", "presence", "of", "fibrinogen", "split", "products", "and", "fragmented", "erythrocytes", "in", "the", "blood", "smear", "help", "to", "confirm", "the", "diagnosis", ".", "The", "therapy", "includes", "fresh", "-", "frozen", "plasma", ",", "heparin", ",", "antibiotics", "and", "surgical", "debridement", "of", "necrotic", "areas", ".", "It", "is", "important", "to", "recognize", "the", "disease", "promptly", "because", "the", "mortality", "rate", "is", "about", "30", "-", "40", "%", "and", "only", "quick", "intervention", "helps", "to", "save", "the", "life", "of", "the", "patient", "." ]

[ "umlsterm" ]

Purpura fulminans is an umlsterm, emergency is an umlsterm, internal medicine is an umlsterm, dermatology is an umlsterm, development is an umlsterm, skin is an umlsterm, necrosis is an umlsterm, disseminated intravascular coagulation is an umlsterm, consumption is an umlsterm, anticoagulant is an umlsterm, signs is an umlsterm, shock is an umlsterm, Purpura fulminans is an umlsterm, form is an umlsterm, protein C deficiency is an umlsterm, causes is an umlsterm, ecchymosis is an umlsterm, blebs is an umlsterm, necrosis is an umlsterm, erythrocytes is an umlsterm, thrombosis is an umlsterm, vessels is an umlsterm, Thrombocytopenia is an umlsterm, coagulation factors is an umlsterm, fibrinogen split products is an umlsterm, erythrocytes is an umlsterm, blood is an umlsterm, diagnosis is an umlsterm, therapy is an umlsterm, plasma is an umlsterm, heparin is an umlsterm, antibiotics is an umlsterm, surgical is an umlsterm, debridement is an umlsterm, disease is an umlsterm, mortality rate is an umlsterm, life is an umlsterm, patient is an umlsterm

DerHautarzt.60470541.eng.abstr_task1

Sentence: Purpura fulminans must be treated as an emergency in internal medicine and dermatology . Its characteristic features are the sudden development of progressively enlarging haemorrhagic skin necrosis , severe disseminated intravascular coagulation with consumption of anticoagulant factors , and signs of shock . Purpura fulminans can be classified into a neonatal form with inherited protein C deficiency and an acquired type for which multiple causes are known . Clinically it is characterized by massive ecchymosis with haemorrhagic blebs and acral necrosis . Histologically the lesions show widespread extravasation of erythrocytes and thrombosis of small vessels . Thrombocytopenia , decrease of coagulation factors , the presence of fibrinogen split products and fragmented erythrocytes in the blood smear help to confirm the diagnosis . The therapy includes fresh-frozen plasma , heparin , antibiotics and surgical debridement of necrotic areas . It is important to recognize the disease promptly because the mortality rate is about 30-40% and only quick intervention helps to save the life of the patient . Instructions: please typing these entity words according to sentence: Purpura fulminans, emergency, internal medicine, dermatology, development, skin, necrosis, disseminated intravascular coagulation, consumption, anticoagulant, signs, shock, Purpura fulminans, form, protein C deficiency, causes, ecchymosis, blebs, necrosis, erythrocytes, thrombosis, vessels, Thrombocytopenia, coagulation factors, fibrinogen split products, erythrocytes, blood, diagnosis, therapy, plasma, heparin, antibiotics, surgical, debridement, disease, mortality rate, life, patient Options: umlsterm

[ "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]

Purpura fulminans must be treated as an emergency in internal medicine and dermatology . Its characteristic features are the sudden development of progressively enlarging haemorrhagic skin necrosis , severe disseminated intravascular coagulation with consumption of anticoagulant factors , and signs of shock . Purpura fulminans can be classified into a neonatal form with inherited protein C deficiency and an acquired type for which multiple causes are known . Clinically it is characterized by massive ecchymosis with haemorrhagic blebs and acral necrosis . Histologically the lesions show widespread extravasation of erythrocytes and thrombosis of small vessels . Thrombocytopenia , decrease of coagulation factors , the presence of fibrinogen split products and fragmented erythrocytes in the blood smear help to confirm the diagnosis . The therapy includes fresh-frozen plasma , heparin , antibiotics and surgical debridement of necrotic areas . It is important to recognize the disease promptly because the mortality rate is about 30-40% and only quick intervention helps to save the life of the patient .

[ "Purpura", "fulminans", "must", "be", "treated", "as", "an", "emergency", "in", "internal", "medicine", "and", "dermatology", ".", "Its", "characteristic", "features", "are", "the", "sudden", "development", "of", "progressively", "enlarging", "haemorrhagic", "skin", "necrosis", ",", "severe", "disseminated", "intravascular", "coagulation", "with", "consumption", "of", "anticoagulant", "factors", ",", "and", "signs", "of", "shock", ".", "Purpura", "fulminans", "can", "be", "classified", "into", "a", "neonatal", "form", "with", "inherited", "protein", "C", "deficiency", "and", "an", "acquired", "type", "for", "which", "multiple", "causes", "are", "known", ".", "Clinically", "it", "is", "characterized", "by", "massive", "ecchymosis", "with", "haemorrhagic", "blebs", "and", "acral", "necrosis", ".", "Histologically", "the", "lesions", "show", "widespread", "extravasation", "of", "erythrocytes", "and", "thrombosis", "of", "small", "vessels", ".", "Thrombocytopenia", ",", "decrease", "of", "coagulation", "factors", ",", "the", "presence", "of", "fibrinogen", "split", "products", "and", "fragmented", "erythrocytes", "in", "the", "blood", "smear", "help", "to", "confirm", "the", "diagnosis", ".", "The", "therapy", "includes", "fresh", "-", "frozen", "plasma", ",", "heparin", ",", "antibiotics", "and", "surgical", "debridement", "of", "necrotic", "areas", ".", "It", "is", "important", "to", "recognize", "the", "disease", "promptly", "because", "the", "mortality", "rate", "is", "about", "30", "-", "40", "%", "and", "only", "quick", "intervention", "helps", "to", "save", "the", "life", "of", "the", "patient", "." ]

[ "umlsterm" ]

Purpura fulminans, emergency, internal medicine, dermatology, development, skin, necrosis, disseminated intravascular coagulation, consumption, anticoagulant, signs, shock, Purpura fulminans, form, protein C deficiency, causes, ecchymosis, blebs, necrosis, erythrocytes, thrombosis, vessels, Thrombocytopenia, coagulation factors, fibrinogen split products, erythrocytes, blood, diagnosis, therapy, plasma, heparin, antibiotics, surgical, debridement, disease, mortality rate, life, patient

DerHautarzt.60470541.eng.abstr_task2

Sentence: Purpura fulminans must be treated as an emergency in internal medicine and dermatology . Its characteristic features are the sudden development of progressively enlarging haemorrhagic skin necrosis , severe disseminated intravascular coagulation with consumption of anticoagulant factors , and signs of shock . Purpura fulminans can be classified into a neonatal form with inherited protein C deficiency and an acquired type for which multiple causes are known . Clinically it is characterized by massive ecchymosis with haemorrhagic blebs and acral necrosis . Histologically the lesions show widespread extravasation of erythrocytes and thrombosis of small vessels . Thrombocytopenia , decrease of coagulation factors , the presence of fibrinogen split products and fragmented erythrocytes in the blood smear help to confirm the diagnosis . The therapy includes fresh-frozen plasma , heparin , antibiotics and surgical debridement of necrotic areas . It is important to recognize the disease promptly because the mortality rate is about 30-40% and only quick intervention helps to save the life of the patient . Instructions: please extract entity words from the input sentence

[ "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]

Purpura fulminans must be treated as an emergency in internal medicine and dermatology . Its characteristic features are the sudden development of progressively enlarging haemorrhagic skin necrosis , severe disseminated intravascular coagulation with consumption of anticoagulant factors , and signs of shock . Purpura fulminans can be classified into a neonatal form with inherited protein C deficiency and an acquired type for which multiple causes are known . Clinically it is characterized by massive ecchymosis with haemorrhagic blebs and acral necrosis . Histologically the lesions show widespread extravasation of erythrocytes and thrombosis of small vessels . Thrombocytopenia , decrease of coagulation factors , the presence of fibrinogen split products and fragmented erythrocytes in the blood smear help to confirm the diagnosis . The therapy includes fresh-frozen plasma , heparin , antibiotics and surgical debridement of necrotic areas . It is important to recognize the disease promptly because the mortality rate is about 30-40% and only quick intervention helps to save the life of the patient .

[ "Purpura", "fulminans", "must", "be", "treated", "as", "an", "emergency", "in", "internal", "medicine", "and", "dermatology", ".", "Its", "characteristic", "features", "are", "the", "sudden", "development", "of", "progressively", "enlarging", "haemorrhagic", "skin", "necrosis", ",", "severe", "disseminated", "intravascular", "coagulation", "with", "consumption", "of", "anticoagulant", "factors", ",", "and", "signs", "of", "shock", ".", "Purpura", "fulminans", "can", "be", "classified", "into", "a", "neonatal", "form", "with", "inherited", "protein", "C", "deficiency", "and", "an", "acquired", "type", "for", "which", "multiple", "causes", "are", "known", ".", "Clinically", "it", "is", "characterized", "by", "massive", "ecchymosis", "with", "haemorrhagic", "blebs", "and", "acral", "necrosis", ".", "Histologically", "the", "lesions", "show", "widespread", "extravasation", "of", "erythrocytes", "and", "thrombosis", "of", "small", "vessels", ".", "Thrombocytopenia", ",", "decrease", "of", "coagulation", "factors", ",", "the", "presence", "of", "fibrinogen", "split", "products", "and", "fragmented", "erythrocytes", "in", "the", "blood", "smear", "help", "to", "confirm", "the", "diagnosis", ".", "The", "therapy", "includes", "fresh", "-", "frozen", "plasma", ",", "heparin", ",", "antibiotics", "and", "surgical", "debridement", "of", "necrotic", "areas", ".", "It", "is", "important", "to", "recognize", "the", "disease", "promptly", "because", "the", "mortality", "rate", "is", "about", "30", "-", "40", "%", "and", "only", "quick", "intervention", "helps", "to", "save", "the", "life", "of", "the", "patient", "." ]

[ "umlsterm" ]

nuclear T cell protein is a protein_family_or_group, TCF-1 is a protein_molecule, TCF-1 knock - out mice is an other_artificial_source

3589_task0

Sentence: Circumvention of tolerance for the nuclear T cell protein TCF-1 by immunization of TCF-1 knock-out mice. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: protein_family_or_group, other_artificial_source, protein_molecule

[ "O", "O", "O", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "B-protein_molecule", "O", "O", "O", "B-other_artificial_source", "I-other_artificial_source", "I-other_artificial_source", "I-other_artificial_source", "I-other_artificial_source", "O" ]

Circumvention of tolerance for the nuclear T cell protein TCF-1 by immunization of TCF-1 knock-out mice.

[ "Circumvention", "of", "tolerance", "for", "the", "nuclear", "T", "cell", "protein", "TCF-1", "by", "immunization", "of", "TCF-1", "knock", "-", "out", "mice", "." ]

[ "(AND protein_N/A protein_N/A)", "other_name", "protein_family_or_group", "cell_type", "cell_line", "other_artificial_source", "protein_molecule", "", "body_part", "multi_cell" ]

nuclear T cell protein is a protein_family_or_group, TCF-1 is a protein_molecule, TCF-1 knock - out mice is an other_artificial_source

3589_task1

Sentence: Circumvention of tolerance for the nuclear T cell protein TCF-1 by immunization of TCF-1 knock-out mice. Instructions: please typing these entity words according to sentence: nuclear T cell protein, TCF-1, TCF-1 knock - out mice Options: protein_family_or_group, other_artificial_source, protein_molecule

[ "O", "O", "O", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "B-protein_molecule", "O", "O", "O", "B-other_artificial_source", "I-other_artificial_source", "I-other_artificial_source", "I-other_artificial_source", "I-other_artificial_source", "O" ]

Circumvention of tolerance for the nuclear T cell protein TCF-1 by immunization of TCF-1 knock-out mice.

[ "Circumvention", "of", "tolerance", "for", "the", "nuclear", "T", "cell", "protein", "TCF-1", "by", "immunization", "of", "TCF-1", "knock", "-", "out", "mice", "." ]

[ "(AND protein_N/A protein_N/A)", "other_name", "protein_family_or_group", "cell_type", "cell_line", "other_artificial_source", "protein_molecule", "", "body_part", "multi_cell" ]

nuclear T cell protein, TCF-1, TCF-1 knock - out mice

3589_task2

Sentence: Circumvention of tolerance for the nuclear T cell protein TCF-1 by immunization of TCF-1 knock-out mice. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "B-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "I-protein_family_or_group", "B-protein_molecule", "O", "O", "O", "B-other_artificial_source", "I-other_artificial_source", "I-other_artificial_source", "I-other_artificial_source", "I-other_artificial_source", "O" ]

Circumvention of tolerance for the nuclear T cell protein TCF-1 by immunization of TCF-1 knock-out mice.

[ "Circumvention", "of", "tolerance", "for", "the", "nuclear", "T", "cell", "protein", "TCF-1", "by", "immunization", "of", "TCF-1", "knock", "-", "out", "mice", "." ]

[ "(AND protein_N/A protein_N/A)", "other_name", "protein_family_or_group", "cell_type", "cell_line", "other_artificial_source", "protein_molecule", "", "body_part", "multi_cell" ]

Glutathione peroxidases is a GENE-N, glutathione peroxidases is a GENE-N, GPxs is a GENE-N, cytosolic GPx is a GENE-N, cGPx is a GENE-N, GPx1 is a GENE-N, phospholipid hydroperoxide GPx is a GENE-N, PHGPX is a GENE-N, GPx4 is a GENE-N, plasma GPx is a GENE-N, pGPX is a GENE-N, GPx3 is a GENE-N, gastrointestinal GPx is a GENE-N, GI - GPx is a GENE-N, GPx2 is a GENE-N, humans , GPx6 is a GENE-Y, GPxs is a GENE-N, alcohols is a CHEMICAL, glutathione is a CHEMICAL, GSH is a CHEMICAL, GPxs is a GENE-N, cGPx is a GENE-Y, PHGPx is a GENE-N, NF - kappaB is a GENE-N, interleukin-1 is a GENE-N, leukotriene is a CHEMICAL, prostanoid is a CHEMICAL, COX-2 is a GENE-Y, GI - GPx is a GENE-N, GI - GPx is a GENE-N, Nrf2 is a GENE-Y, PHGPx is a GENE-N, cGPx is a GENE-Y, PHGPx is a GENE-N, GI - GPx is a GENE-N, GPxs is a GENE-N

2969_task0

Sentence: Glutathione peroxidases and redox-regulated transcription factors. Analysis of the selenoproteome identified five glutathione peroxidases (GPxs) in mammals: cytosolic GPx (cGPx, GPx1), phospholipid hydroperoxide GPx (PHGPX, GPx4), plasma GPx (pGPX, GPx3), gastrointestinal GPx (GI-GPx, GPx2) and, in humans, GPx6, which is restricted to the olfactory system. GPxs reduce hydroperoxides to the corresponding alcohols by means of glutathione (GSH). They have long been considered to only act as antioxidant enzymes. Increasing evidence, however, suggests that nature has not created redundant GPxs just to detoxify hydroperoxides. cGPx clearly acts as an antioxidant, as convincingly demonstrated in GPx1-knockout mice. PHGPx specifically interferes with NF-kappaB activation by interleukin-1, reduces leukotriene and prostanoid biosynthesis, prevents COX-2 expression, and is indispensable for sperm maturation and embryogenesis. GI-GPx, which is not exclusively expressed in the gastrointestinal system, is upregulated in colon and skin cancers and in certain cultured cancer cells. GI-GPx is a target for Nrf2, and thus is part of the adaptive response by itself, while PHGPx might prevent cancer by interfering with inflammatory pathways. In conclusion, cGPx, PHGPx and GI-GPx have distinct roles, particularly in cellular defence mechanisms. Redox sensing and redox regulation of metabolic events have become attractive paradigms to unravel the specific and in part still enigmatic roles of GPxs. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, GENE-N, CHEMICAL

[ "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "B-GENE-N", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "B-GENE-N", "O", "O", "B-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "B-GENE-N", "O", "O", "B-GENE-N", "I-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "B-GENE-N", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "B-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O" ]

Glutathione peroxidases and redox-regulated transcription factors. Analysis of the selenoproteome identified five glutathione peroxidases (GPxs) in mammals: cytosolic GPx (cGPx, GPx1), phospholipid hydroperoxide GPx (PHGPX, GPx4), plasma GPx (pGPX, GPx3), gastrointestinal GPx (GI-GPx, GPx2) and, in humans, GPx6, which is restricted to the olfactory system. GPxs reduce hydroperoxides to the corresponding alcohols by means of glutathione (GSH). They have long been considered to only act as antioxidant enzymes. Increasing evidence, however, suggests that nature has not created redundant GPxs just to detoxify hydroperoxides. cGPx clearly acts as an antioxidant, as convincingly demonstrated in GPx1-knockout mice. PHGPx specifically interferes with NF-kappaB activation by interleukin-1, reduces leukotriene and prostanoid biosynthesis, prevents COX-2 expression, and is indispensable for sperm maturation and embryogenesis. GI-GPx, which is not exclusively expressed in the gastrointestinal system, is upregulated in colon and skin cancers and in certain cultured cancer cells. GI-GPx is a target for Nrf2, and thus is part of the adaptive response by itself, while PHGPx might prevent cancer by interfering with inflammatory pathways. In conclusion, cGPx, PHGPx and GI-GPx have distinct roles, particularly in cellular defence mechanisms. Redox sensing and redox regulation of metabolic events have become attractive paradigms to unravel the specific and in part still enigmatic roles of GPxs.

[ "Glutathione", "peroxidases", "and", "redox", "-", "regulated", "transcription", "factors", ".", "\n", "Analysis", "of", "the", "selenoproteome", "identified", "five", "glutathione", "peroxidases", "(", "GPxs", ")", "in", "mammals", ":", "cytosolic", "GPx", "(", "cGPx", ",", "GPx1", ")", ",", "phospholipid", "hydroperoxide", "GPx", "(", "PHGPX", ",", "GPx4", ")", ",", "plasma", "GPx", "(", "pGPX", ",", "GPx3", ")", ",", "gastrointestinal", "GPx", "(", "GI", "-", "GPx", ",", "GPx2", ")", "and", ",", "in", "humans", ",", "GPx6", ",", "which", "is", "restricted", "to", "the", "olfactory", "system", ".", "GPxs", "reduce", "hydroperoxides", "to", "the", "corresponding", "alcohols", "by", "means", "of", "glutathione", "(", "GSH", ")", ".", "They", "have", "long", "been", "considered", "to", "only", "act", "as", "antioxidant", "enzymes", ".", "Increasing", "evidence", ",", "however", ",", "suggests", "that", "nature", "has", "not", "created", "redundant", "GPxs", "just", "to", "detoxify", "hydroperoxides", ".", "cGPx", "clearly", "acts", "as", "an", "antioxidant", ",", "as", "convincingly", "demonstrated", "in", "GPx1-knockout", "mice", ".", "PHGPx", "specifically", "interferes", "with", "NF", "-", "kappaB", "activation", "by", "interleukin-1", ",", "reduces", "leukotriene", "and", "prostanoid", "biosynthesis", ",", "prevents", "COX-2", "expression", ",", "and", "is", "indispensable", "for", "sperm", "maturation", "and", "embryogenesis", ".", "GI", "-", "GPx", ",", "which", "is", "not", "exclusively", "expressed", "in", "the", "gastrointestinal", "system", ",", "is", "upregulated", "in", "colon", "and", "skin", "cancers", "and", "in", "certain", "cultured", "cancer", "cells", ".", "GI", "-", "GPx", "is", "a", "target", "for", "Nrf2", ",", "and", "thus", "is", "part", "of", "the", "adaptive", "response", "by", "itself", ",", "while", "PHGPx", "might", "prevent", "cancer", "by", "interfering", "with", "inflammatory", "pathways", ".", "In", "conclusion", ",", "cGPx", ",", "PHGPx", "and", "GI", "-", "GPx", "have", "distinct", "roles", ",", "particularly", "in", "cellular", "defence", "mechanisms", ".", "Redox", "sensing", "and", "redox", "regulation", "of", "metabolic", "events", "have", "become", "attractive", "paradigms", "to", "unravel", "the", "specific", "and", "in", "part", "still", "enigmatic", "roles", "of", "GPxs", "." ]

[ "GENE-N", "GENE-Y", "CHEMICAL" ]

Glutathione peroxidases is a GENE-N, glutathione peroxidases is a GENE-N, GPxs is a GENE-N, cytosolic GPx is a GENE-N, cGPx is a GENE-N, GPx1 is a GENE-N, phospholipid hydroperoxide GPx is a GENE-N, PHGPX is a GENE-N, GPx4 is a GENE-N, plasma GPx is a GENE-N, pGPX is a GENE-N, GPx3 is a GENE-N, gastrointestinal GPx is a GENE-N, GI - GPx is a GENE-N, GPx2 is a GENE-N, humans , GPx6 is a GENE-Y, GPxs is a GENE-N, alcohols is a CHEMICAL, glutathione is a CHEMICAL, GSH is a CHEMICAL, GPxs is a GENE-N, cGPx is a GENE-Y, PHGPx is a GENE-N, NF - kappaB is a GENE-N, interleukin-1 is a GENE-N, leukotriene is a CHEMICAL, prostanoid is a CHEMICAL, COX-2 is a GENE-Y, GI - GPx is a GENE-N, GI - GPx is a GENE-N, Nrf2 is a GENE-Y, PHGPx is a GENE-N, cGPx is a GENE-Y, PHGPx is a GENE-N, GI - GPx is a GENE-N, GPxs is a GENE-N

2969_task1

Sentence: Glutathione peroxidases and redox-regulated transcription factors. Analysis of the selenoproteome identified five glutathione peroxidases (GPxs) in mammals: cytosolic GPx (cGPx, GPx1), phospholipid hydroperoxide GPx (PHGPX, GPx4), plasma GPx (pGPX, GPx3), gastrointestinal GPx (GI-GPx, GPx2) and, in humans, GPx6, which is restricted to the olfactory system. GPxs reduce hydroperoxides to the corresponding alcohols by means of glutathione (GSH). They have long been considered to only act as antioxidant enzymes. Increasing evidence, however, suggests that nature has not created redundant GPxs just to detoxify hydroperoxides. cGPx clearly acts as an antioxidant, as convincingly demonstrated in GPx1-knockout mice. PHGPx specifically interferes with NF-kappaB activation by interleukin-1, reduces leukotriene and prostanoid biosynthesis, prevents COX-2 expression, and is indispensable for sperm maturation and embryogenesis. GI-GPx, which is not exclusively expressed in the gastrointestinal system, is upregulated in colon and skin cancers and in certain cultured cancer cells. GI-GPx is a target for Nrf2, and thus is part of the adaptive response by itself, while PHGPx might prevent cancer by interfering with inflammatory pathways. In conclusion, cGPx, PHGPx and GI-GPx have distinct roles, particularly in cellular defence mechanisms. Redox sensing and redox regulation of metabolic events have become attractive paradigms to unravel the specific and in part still enigmatic roles of GPxs. Instructions: please typing these entity words according to sentence: Glutathione peroxidases, glutathione peroxidases, GPxs, cytosolic GPx, cGPx, GPx1, phospholipid hydroperoxide GPx, PHGPX, GPx4, plasma GPx, pGPX, GPx3, gastrointestinal GPx, GI - GPx, GPx2, humans , GPx6, GPxs, alcohols, glutathione, GSH, GPxs, cGPx, PHGPx, NF - kappaB, interleukin-1, leukotriene, prostanoid, COX-2, GI - GPx, GI - GPx, Nrf2, PHGPx, cGPx, PHGPx, GI - GPx, GPxs Options: GENE-Y, GENE-N, CHEMICAL

[ "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "B-GENE-N", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "B-GENE-N", "O", "O", "B-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "B-GENE-N", "O", "O", "B-GENE-N", "I-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "B-GENE-N", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "B-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O" ]

Glutathione peroxidases and redox-regulated transcription factors. Analysis of the selenoproteome identified five glutathione peroxidases (GPxs) in mammals: cytosolic GPx (cGPx, GPx1), phospholipid hydroperoxide GPx (PHGPX, GPx4), plasma GPx (pGPX, GPx3), gastrointestinal GPx (GI-GPx, GPx2) and, in humans, GPx6, which is restricted to the olfactory system. GPxs reduce hydroperoxides to the corresponding alcohols by means of glutathione (GSH). They have long been considered to only act as antioxidant enzymes. Increasing evidence, however, suggests that nature has not created redundant GPxs just to detoxify hydroperoxides. cGPx clearly acts as an antioxidant, as convincingly demonstrated in GPx1-knockout mice. PHGPx specifically interferes with NF-kappaB activation by interleukin-1, reduces leukotriene and prostanoid biosynthesis, prevents COX-2 expression, and is indispensable for sperm maturation and embryogenesis. GI-GPx, which is not exclusively expressed in the gastrointestinal system, is upregulated in colon and skin cancers and in certain cultured cancer cells. GI-GPx is a target for Nrf2, and thus is part of the adaptive response by itself, while PHGPx might prevent cancer by interfering with inflammatory pathways. In conclusion, cGPx, PHGPx and GI-GPx have distinct roles, particularly in cellular defence mechanisms. Redox sensing and redox regulation of metabolic events have become attractive paradigms to unravel the specific and in part still enigmatic roles of GPxs.

[ "Glutathione", "peroxidases", "and", "redox", "-", "regulated", "transcription", "factors", ".", "\n", "Analysis", "of", "the", "selenoproteome", "identified", "five", "glutathione", "peroxidases", "(", "GPxs", ")", "in", "mammals", ":", "cytosolic", "GPx", "(", "cGPx", ",", "GPx1", ")", ",", "phospholipid", "hydroperoxide", "GPx", "(", "PHGPX", ",", "GPx4", ")", ",", "plasma", "GPx", "(", "pGPX", ",", "GPx3", ")", ",", "gastrointestinal", "GPx", "(", "GI", "-", "GPx", ",", "GPx2", ")", "and", ",", "in", "humans", ",", "GPx6", ",", "which", "is", "restricted", "to", "the", "olfactory", "system", ".", "GPxs", "reduce", "hydroperoxides", "to", "the", "corresponding", "alcohols", "by", "means", "of", "glutathione", "(", "GSH", ")", ".", "They", "have", "long", "been", "considered", "to", "only", "act", "as", "antioxidant", "enzymes", ".", "Increasing", "evidence", ",", "however", ",", "suggests", "that", "nature", "has", "not", "created", "redundant", "GPxs", "just", "to", "detoxify", "hydroperoxides", ".", "cGPx", "clearly", "acts", "as", "an", "antioxidant", ",", "as", "convincingly", "demonstrated", "in", "GPx1-knockout", "mice", ".", "PHGPx", "specifically", "interferes", "with", "NF", "-", "kappaB", "activation", "by", "interleukin-1", ",", "reduces", "leukotriene", "and", "prostanoid", "biosynthesis", ",", "prevents", "COX-2", "expression", ",", "and", "is", "indispensable", "for", "sperm", "maturation", "and", "embryogenesis", ".", "GI", "-", "GPx", ",", "which", "is", "not", "exclusively", "expressed", "in", "the", "gastrointestinal", "system", ",", "is", "upregulated", "in", "colon", "and", "skin", "cancers", "and", "in", "certain", "cultured", "cancer", "cells", ".", "GI", "-", "GPx", "is", "a", "target", "for", "Nrf2", ",", "and", "thus", "is", "part", "of", "the", "adaptive", "response", "by", "itself", ",", "while", "PHGPx", "might", "prevent", "cancer", "by", "interfering", "with", "inflammatory", "pathways", ".", "In", "conclusion", ",", "cGPx", ",", "PHGPx", "and", "GI", "-", "GPx", "have", "distinct", "roles", ",", "particularly", "in", "cellular", "defence", "mechanisms", ".", "Redox", "sensing", "and", "redox", "regulation", "of", "metabolic", "events", "have", "become", "attractive", "paradigms", "to", "unravel", "the", "specific", "and", "in", "part", "still", "enigmatic", "roles", "of", "GPxs", "." ]

[ "GENE-N", "GENE-Y", "CHEMICAL" ]

Glutathione peroxidases, glutathione peroxidases, GPxs, cytosolic GPx, cGPx, GPx1, phospholipid hydroperoxide GPx, PHGPX, GPx4, plasma GPx, pGPX, GPx3, gastrointestinal GPx, GI - GPx, GPx2, humans , GPx6, GPxs, alcohols, glutathione, GSH, GPxs, cGPx, PHGPx, NF - kappaB, interleukin-1, leukotriene, prostanoid, COX-2, GI - GPx, GI - GPx, Nrf2, PHGPx, cGPx, PHGPx, GI - GPx, GPxs

2969_task2

Sentence: Glutathione peroxidases and redox-regulated transcription factors. Analysis of the selenoproteome identified five glutathione peroxidases (GPxs) in mammals: cytosolic GPx (cGPx, GPx1), phospholipid hydroperoxide GPx (PHGPX, GPx4), plasma GPx (pGPX, GPx3), gastrointestinal GPx (GI-GPx, GPx2) and, in humans, GPx6, which is restricted to the olfactory system. GPxs reduce hydroperoxides to the corresponding alcohols by means of glutathione (GSH). They have long been considered to only act as antioxidant enzymes. Increasing evidence, however, suggests that nature has not created redundant GPxs just to detoxify hydroperoxides. cGPx clearly acts as an antioxidant, as convincingly demonstrated in GPx1-knockout mice. PHGPx specifically interferes with NF-kappaB activation by interleukin-1, reduces leukotriene and prostanoid biosynthesis, prevents COX-2 expression, and is indispensable for sperm maturation and embryogenesis. GI-GPx, which is not exclusively expressed in the gastrointestinal system, is upregulated in colon and skin cancers and in certain cultured cancer cells. GI-GPx is a target for Nrf2, and thus is part of the adaptive response by itself, while PHGPx might prevent cancer by interfering with inflammatory pathways. In conclusion, cGPx, PHGPx and GI-GPx have distinct roles, particularly in cellular defence mechanisms. Redox sensing and redox regulation of metabolic events have become attractive paradigms to unravel the specific and in part still enigmatic roles of GPxs. Instructions: please extract entity words from the input sentence

[ "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "B-GENE-N", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "B-GENE-N", "O", "O", "B-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "B-GENE-N", "O", "O", "B-GENE-N", "I-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-N", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "B-GENE-N", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "B-GENE-N", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O" ]

Glutathione peroxidases and redox-regulated transcription factors. Analysis of the selenoproteome identified five glutathione peroxidases (GPxs) in mammals: cytosolic GPx (cGPx, GPx1), phospholipid hydroperoxide GPx (PHGPX, GPx4), plasma GPx (pGPX, GPx3), gastrointestinal GPx (GI-GPx, GPx2) and, in humans, GPx6, which is restricted to the olfactory system. GPxs reduce hydroperoxides to the corresponding alcohols by means of glutathione (GSH). They have long been considered to only act as antioxidant enzymes. Increasing evidence, however, suggests that nature has not created redundant GPxs just to detoxify hydroperoxides. cGPx clearly acts as an antioxidant, as convincingly demonstrated in GPx1-knockout mice. PHGPx specifically interferes with NF-kappaB activation by interleukin-1, reduces leukotriene and prostanoid biosynthesis, prevents COX-2 expression, and is indispensable for sperm maturation and embryogenesis. GI-GPx, which is not exclusively expressed in the gastrointestinal system, is upregulated in colon and skin cancers and in certain cultured cancer cells. GI-GPx is a target for Nrf2, and thus is part of the adaptive response by itself, while PHGPx might prevent cancer by interfering with inflammatory pathways. In conclusion, cGPx, PHGPx and GI-GPx have distinct roles, particularly in cellular defence mechanisms. Redox sensing and redox regulation of metabolic events have become attractive paradigms to unravel the specific and in part still enigmatic roles of GPxs.

[ "Glutathione", "peroxidases", "and", "redox", "-", "regulated", "transcription", "factors", ".", "\n", "Analysis", "of", "the", "selenoproteome", "identified", "five", "glutathione", "peroxidases", "(", "GPxs", ")", "in", "mammals", ":", "cytosolic", "GPx", "(", "cGPx", ",", "GPx1", ")", ",", "phospholipid", "hydroperoxide", "GPx", "(", "PHGPX", ",", "GPx4", ")", ",", "plasma", "GPx", "(", "pGPX", ",", "GPx3", ")", ",", "gastrointestinal", "GPx", "(", "GI", "-", "GPx", ",", "GPx2", ")", "and", ",", "in", "humans", ",", "GPx6", ",", "which", "is", "restricted", "to", "the", "olfactory", "system", ".", "GPxs", "reduce", "hydroperoxides", "to", "the", "corresponding", "alcohols", "by", "means", "of", "glutathione", "(", "GSH", ")", ".", "They", "have", "long", "been", "considered", "to", "only", "act", "as", "antioxidant", "enzymes", ".", "Increasing", "evidence", ",", "however", ",", "suggests", "that", "nature", "has", "not", "created", "redundant", "GPxs", "just", "to", "detoxify", "hydroperoxides", ".", "cGPx", "clearly", "acts", "as", "an", "antioxidant", ",", "as", "convincingly", "demonstrated", "in", "GPx1-knockout", "mice", ".", "PHGPx", "specifically", "interferes", "with", "NF", "-", "kappaB", "activation", "by", "interleukin-1", ",", "reduces", "leukotriene", "and", "prostanoid", "biosynthesis", ",", "prevents", "COX-2", "expression", ",", "and", "is", "indispensable", "for", "sperm", "maturation", "and", "embryogenesis", ".", "GI", "-", "GPx", ",", "which", "is", "not", "exclusively", "expressed", "in", "the", "gastrointestinal", "system", ",", "is", "upregulated", "in", "colon", "and", "skin", "cancers", "and", "in", "certain", "cultured", "cancer", "cells", ".", "GI", "-", "GPx", "is", "a", "target", "for", "Nrf2", ",", "and", "thus", "is", "part", "of", "the", "adaptive", "response", "by", "itself", ",", "while", "PHGPx", "might", "prevent", "cancer", "by", "interfering", "with", "inflammatory", "pathways", ".", "In", "conclusion", ",", "cGPx", ",", "PHGPx", "and", "GI", "-", "GPx", "have", "distinct", "roles", ",", "particularly", "in", "cellular", "defence", "mechanisms", ".", "Redox", "sensing", "and", "redox", "regulation", "of", "metabolic", "events", "have", "become", "attractive", "paradigms", "to", "unravel", "the", "specific", "and", "in", "part", "still", "enigmatic", "roles", "of", "GPxs", "." ]

[ "GENE-N", "GENE-Y", "CHEMICAL" ]

Suizide is an umlsterm, Suizide is an umlsterm, Suizid is an umlsterm, Sterbehilfeorganisation is an umlsterm, Analyse is an umlsterm, Sterbehilfeorganisation is an umlsterm, Kranken is an umlsterm, Suizid is an umlsterm

DerNervenarzt.90701014.ger.abstr_task0

Sentence: In der Region Basel wurden zwischen 1992 und 1997 43 begleitete Suizide erfasst . Das sind rund 8% aller Suizide in der Region . Die Beihilfe zum Suizid erfolgte durch die Sterbehilfeorganisation Exit . Bei 6 Suizidentinnen und Suizidenten ( 14% ) war eine psychiatrische Vorgeschichte bekannt . Bei 4 von ihnen bestanden gleichzeitig schwere koerperliche Erkrankungen . Die kasuistische Analyse prueft die Frage , ob und unter welchen Bedingungen die Sterbehilfeorganisation Exit bei psychisch Kranken Beihilfe zum Suizid leistet und welche Probleme daraus erwachsen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]

In der Region Basel wurden zwischen 1992 und 1997 43 begleitete Suizide erfasst . Das sind rund 8% aller Suizide in der Region . Die Beihilfe zum Suizid erfolgte durch die Sterbehilfeorganisation Exit . Bei 6 Suizidentinnen und Suizidenten ( 14% ) war eine psychiatrische Vorgeschichte bekannt . Bei 4 von ihnen bestanden gleichzeitig schwere koerperliche Erkrankungen . Die kasuistische Analyse prueft die Frage , ob und unter welchen Bedingungen die Sterbehilfeorganisation Exit bei psychisch Kranken Beihilfe zum Suizid leistet und welche Probleme daraus erwachsen .

[ "In", "der", "Region", "Basel", "wurden", "zwischen", "1992", "und", "1997", "43", "begleitete", "Suizide", "erfasst", ".", "Das", "sind", "rund", "8", "%", "aller", "Suizide", "in", "der", "Region", ".", "Die", "Beihilfe", "zum", "Suizid", "erfolgte", "durch", "die", "Sterbehilfeorganisation", "Exit", ".", "Bei", "6", "Suizidentinnen", "und", "Suizidenten", "(", "14", "%", ")", "war", "eine", "psychiatrische", "Vorgeschichte", "bekannt", ".", "Bei", "4", "von", "ihnen", "bestanden", "gleichzeitig", "schwere", "koerperliche", "Erkrankungen", ".", "Die", "kasuistische", "Analyse", "prueft", "die", "Frage", ",", "ob", "und", "unter", "welchen", "Bedingungen", "die", "Sterbehilfeorganisation", "Exit", "bei", "psychisch", "Kranken", "Beihilfe", "zum", "Suizid", "leistet", "und", "welche", "Probleme", "daraus", "erwachsen", "." ]

[ "umlsterm" ]

Suizide is an umlsterm, Suizide is an umlsterm, Suizid is an umlsterm, Sterbehilfeorganisation is an umlsterm, Analyse is an umlsterm, Sterbehilfeorganisation is an umlsterm, Kranken is an umlsterm, Suizid is an umlsterm

DerNervenarzt.90701014.ger.abstr_task1

Sentence: In der Region Basel wurden zwischen 1992 und 1997 43 begleitete Suizide erfasst . Das sind rund 8% aller Suizide in der Region . Die Beihilfe zum Suizid erfolgte durch die Sterbehilfeorganisation Exit . Bei 6 Suizidentinnen und Suizidenten ( 14% ) war eine psychiatrische Vorgeschichte bekannt . Bei 4 von ihnen bestanden gleichzeitig schwere koerperliche Erkrankungen . Die kasuistische Analyse prueft die Frage , ob und unter welchen Bedingungen die Sterbehilfeorganisation Exit bei psychisch Kranken Beihilfe zum Suizid leistet und welche Probleme daraus erwachsen . Instructions: please typing these entity words according to sentence: Suizide, Suizide, Suizid, Sterbehilfeorganisation, Analyse, Sterbehilfeorganisation, Kranken, Suizid Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]

In der Region Basel wurden zwischen 1992 und 1997 43 begleitete Suizide erfasst . Das sind rund 8% aller Suizide in der Region . Die Beihilfe zum Suizid erfolgte durch die Sterbehilfeorganisation Exit . Bei 6 Suizidentinnen und Suizidenten ( 14% ) war eine psychiatrische Vorgeschichte bekannt . Bei 4 von ihnen bestanden gleichzeitig schwere koerperliche Erkrankungen . Die kasuistische Analyse prueft die Frage , ob und unter welchen Bedingungen die Sterbehilfeorganisation Exit bei psychisch Kranken Beihilfe zum Suizid leistet und welche Probleme daraus erwachsen .

[ "In", "der", "Region", "Basel", "wurden", "zwischen", "1992", "und", "1997", "43", "begleitete", "Suizide", "erfasst", ".", "Das", "sind", "rund", "8", "%", "aller", "Suizide", "in", "der", "Region", ".", "Die", "Beihilfe", "zum", "Suizid", "erfolgte", "durch", "die", "Sterbehilfeorganisation", "Exit", ".", "Bei", "6", "Suizidentinnen", "und", "Suizidenten", "(", "14", "%", ")", "war", "eine", "psychiatrische", "Vorgeschichte", "bekannt", ".", "Bei", "4", "von", "ihnen", "bestanden", "gleichzeitig", "schwere", "koerperliche", "Erkrankungen", ".", "Die", "kasuistische", "Analyse", "prueft", "die", "Frage", ",", "ob", "und", "unter", "welchen", "Bedingungen", "die", "Sterbehilfeorganisation", "Exit", "bei", "psychisch", "Kranken", "Beihilfe", "zum", "Suizid", "leistet", "und", "welche", "Probleme", "daraus", "erwachsen", "." ]

[ "umlsterm" ]

Suizide, Suizide, Suizid, Sterbehilfeorganisation, Analyse, Sterbehilfeorganisation, Kranken, Suizid

DerNervenarzt.90701014.ger.abstr_task2

Sentence: In der Region Basel wurden zwischen 1992 und 1997 43 begleitete Suizide erfasst . Das sind rund 8% aller Suizide in der Region . Die Beihilfe zum Suizid erfolgte durch die Sterbehilfeorganisation Exit . Bei 6 Suizidentinnen und Suizidenten ( 14% ) war eine psychiatrische Vorgeschichte bekannt . Bei 4 von ihnen bestanden gleichzeitig schwere koerperliche Erkrankungen . Die kasuistische Analyse prueft die Frage , ob und unter welchen Bedingungen die Sterbehilfeorganisation Exit bei psychisch Kranken Beihilfe zum Suizid leistet und welche Probleme daraus erwachsen . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]

In der Region Basel wurden zwischen 1992 und 1997 43 begleitete Suizide erfasst . Das sind rund 8% aller Suizide in der Region . Die Beihilfe zum Suizid erfolgte durch die Sterbehilfeorganisation Exit . Bei 6 Suizidentinnen und Suizidenten ( 14% ) war eine psychiatrische Vorgeschichte bekannt . Bei 4 von ihnen bestanden gleichzeitig schwere koerperliche Erkrankungen . Die kasuistische Analyse prueft die Frage , ob und unter welchen Bedingungen die Sterbehilfeorganisation Exit bei psychisch Kranken Beihilfe zum Suizid leistet und welche Probleme daraus erwachsen .

[ "In", "der", "Region", "Basel", "wurden", "zwischen", "1992", "und", "1997", "43", "begleitete", "Suizide", "erfasst", ".", "Das", "sind", "rund", "8", "%", "aller", "Suizide", "in", "der", "Region", ".", "Die", "Beihilfe", "zum", "Suizid", "erfolgte", "durch", "die", "Sterbehilfeorganisation", "Exit", ".", "Bei", "6", "Suizidentinnen", "und", "Suizidenten", "(", "14", "%", ")", "war", "eine", "psychiatrische", "Vorgeschichte", "bekannt", ".", "Bei", "4", "von", "ihnen", "bestanden", "gleichzeitig", "schwere", "koerperliche", "Erkrankungen", ".", "Die", "kasuistische", "Analyse", "prueft", "die", "Frage", ",", "ob", "und", "unter", "welchen", "Bedingungen", "die", "Sterbehilfeorganisation", "Exit", "bei", "psychisch", "Kranken", "Beihilfe", "zum", "Suizid", "leistet", "und", "welche", "Probleme", "daraus", "erwachsen", "." ]

[ "umlsterm" ]

6-OHDA is a CHEMICAL, Nrf2 is a GENE-Y, NF - κB is a GENE-N

23274087_task0

Sentence: 6-OHDA-induced apoptosis and mitochondrial dysfunction are mediated by early modulation of intracellular signals and interaction of Nrf2 and NF-κB factors. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N, GENE-Y, CHEMICAL

[ "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O" ]

6-OHDA-induced apoptosis and mitochondrial dysfunction are mediated by early modulation of intracellular signals and interaction of Nrf2 and NF-κB factors.

[ "6-OHDA", "-", "induced", "apoptosis", "and", "mitochondrial", "dysfunction", "are", "mediated", "by", "early", "modulation", "of", "intracellular", "signals", "and", "interaction", "of", "Nrf2", "and", "NF", "-", "κB", "factors", "." ]

[ "GENE-Y", "GENE-N", "CHEMICAL" ]

6-OHDA is a CHEMICAL, Nrf2 is a GENE-Y, NF - κB is a GENE-N

23274087_task1

Sentence: 6-OHDA-induced apoptosis and mitochondrial dysfunction are mediated by early modulation of intracellular signals and interaction of Nrf2 and NF-κB factors. Instructions: please typing these entity words according to sentence: 6-OHDA, Nrf2, NF - κB Options: GENE-N, GENE-Y, CHEMICAL

[ "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O" ]

6-OHDA-induced apoptosis and mitochondrial dysfunction are mediated by early modulation of intracellular signals and interaction of Nrf2 and NF-κB factors.

[ "6-OHDA", "-", "induced", "apoptosis", "and", "mitochondrial", "dysfunction", "are", "mediated", "by", "early", "modulation", "of", "intracellular", "signals", "and", "interaction", "of", "Nrf2", "and", "NF", "-", "κB", "factors", "." ]

[ "GENE-Y", "GENE-N", "CHEMICAL" ]

6-OHDA, Nrf2, NF - κB

23274087_task2

Sentence: 6-OHDA-induced apoptosis and mitochondrial dysfunction are mediated by early modulation of intracellular signals and interaction of Nrf2 and NF-κB factors. Instructions: please extract entity words from the input sentence

[ "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O" ]

6-OHDA-induced apoptosis and mitochondrial dysfunction are mediated by early modulation of intracellular signals and interaction of Nrf2 and NF-κB factors.

[ "6-OHDA", "-", "induced", "apoptosis", "and", "mitochondrial", "dysfunction", "are", "mediated", "by", "early", "modulation", "of", "intracellular", "signals", "and", "interaction", "of", "Nrf2", "and", "NF", "-", "κB", "factors", "." ]

[ "GENE-Y", "GENE-N", "CHEMICAL" ]

family is an umlsterm, signs is an umlsterm, syndrome is an umlsterm, hearing loss is an umlsterm, leukocyte is an umlsterm, inclusion bodies is an umlsterm, eye anomalies is an umlsterm, nephritis is an umlsterm

HNO.00480616.eng.abstr_task0

Sentence: In this article , we report on a family in which five examined members showed clinical signs of Fechtner syndrome , a condition which consists of hearing loss ( 49% ) , macrothrombocytopenia ( 100% ) , leukocyte inclusion bodies ( 100% ) , eye anomalies ( 54.3% ) , and nephritis ( 38.7% ) . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]

In this article , we report on a family in which five examined members showed clinical signs of Fechtner syndrome , a condition which consists of hearing loss ( 49% ) , macrothrombocytopenia ( 100% ) , leukocyte inclusion bodies ( 100% ) , eye anomalies ( 54.3% ) , and nephritis ( 38.7% ) .

[ "In", "this", "article", ",", "we", "report", "on", "a", "family", "in", "which", "five", "examined", "members", "showed", "clinical", "signs", "of", "Fechtner", "syndrome", ",", "a", "condition", "which", "consists", "of", "hearing", "loss", "(", "49", "%", ")", ",", "macrothrombocytopenia", "(", "100", "%", ")", ",", "leukocyte", "inclusion", "bodies", "(", "100", "%", ")", ",", "eye", "anomalies", "(", "54.3", "%", ")", ",", "and", "nephritis", "(", "38.7", "%", ")", "." ]

[ "umlsterm" ]

family is an umlsterm, signs is an umlsterm, syndrome is an umlsterm, hearing loss is an umlsterm, leukocyte is an umlsterm, inclusion bodies is an umlsterm, eye anomalies is an umlsterm, nephritis is an umlsterm

HNO.00480616.eng.abstr_task1

Sentence: In this article , we report on a family in which five examined members showed clinical signs of Fechtner syndrome , a condition which consists of hearing loss ( 49% ) , macrothrombocytopenia ( 100% ) , leukocyte inclusion bodies ( 100% ) , eye anomalies ( 54.3% ) , and nephritis ( 38.7% ) . Instructions: please typing these entity words according to sentence: family, signs, syndrome, hearing loss, leukocyte, inclusion bodies, eye anomalies, nephritis Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]

In this article , we report on a family in which five examined members showed clinical signs of Fechtner syndrome , a condition which consists of hearing loss ( 49% ) , macrothrombocytopenia ( 100% ) , leukocyte inclusion bodies ( 100% ) , eye anomalies ( 54.3% ) , and nephritis ( 38.7% ) .

[ "In", "this", "article", ",", "we", "report", "on", "a", "family", "in", "which", "five", "examined", "members", "showed", "clinical", "signs", "of", "Fechtner", "syndrome", ",", "a", "condition", "which", "consists", "of", "hearing", "loss", "(", "49", "%", ")", ",", "macrothrombocytopenia", "(", "100", "%", ")", ",", "leukocyte", "inclusion", "bodies", "(", "100", "%", ")", ",", "eye", "anomalies", "(", "54.3", "%", ")", ",", "and", "nephritis", "(", "38.7", "%", ")", "." ]

[ "umlsterm" ]

family, signs, syndrome, hearing loss, leukocyte, inclusion bodies, eye anomalies, nephritis

HNO.00480616.eng.abstr_task2

Sentence: In this article , we report on a family in which five examined members showed clinical signs of Fechtner syndrome , a condition which consists of hearing loss ( 49% ) , macrothrombocytopenia ( 100% ) , leukocyte inclusion bodies ( 100% ) , eye anomalies ( 54.3% ) , and nephritis ( 38.7% ) . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]

In this article , we report on a family in which five examined members showed clinical signs of Fechtner syndrome , a condition which consists of hearing loss ( 49% ) , macrothrombocytopenia ( 100% ) , leukocyte inclusion bodies ( 100% ) , eye anomalies ( 54.3% ) , and nephritis ( 38.7% ) .

[ "In", "this", "article", ",", "we", "report", "on", "a", "family", "in", "which", "five", "examined", "members", "showed", "clinical", "signs", "of", "Fechtner", "syndrome", ",", "a", "condition", "which", "consists", "of", "hearing", "loss", "(", "49", "%", ")", ",", "macrothrombocytopenia", "(", "100", "%", ")", ",", "leukocyte", "inclusion", "bodies", "(", "100", "%", ")", ",", "eye", "anomalies", "(", "54.3", "%", ")", ",", "and", "nephritis", "(", "38.7", "%", ")", "." ]

[ "umlsterm" ]

phrenic nerve is a Participant_Condition, pneumonectomy is a Intervention_Surgical, 10 is a Participant_Sample-size, lung cancer is a Participant_Condition, ultrasonographic is a Intervention_Other

61358_task0

Sentence: Effect of phrenic nerve palsy on early postoperative lung function after pneumonectomy : a prospective study . BACKGROUND The issue of phrenic nerve preservation during pneumonectomy is still an unanswered question . So far , its direct effect on immediate postoperative pulmonary lung function has never been evaluated in a prospective trial . METHODS We conducted a prospective crossover study including 10 patients undergoing pneumonectomy for lung cancer between July 2011 and July 2012 . After written informed consent , all consecutive patients who agreed to take part in the study and in whom preservation of the phrenic nerve during operation was possible , were included in the study . Upon completion of lung resection , a catheter was placed in the proximal paraphrenic tissue on the pericardial surface . After an initial phase of recovery of 5 days all patients underwent ultrasonographic assessment of diaphragmatic motion followed by lung function testing with and without induced phrenic nerve palsy . The controlled , temporary paralysis of the ipsilateral hemidiaphragm was achieved by local administration of lidocaine 1 % at a rate of 3 mL/h ( 30 mg/h ) via the above-mentioned catheter . RESULTS Temporary phrenic nerve palsy was accomplished in all but 1 patient with suspected catheter dislocation . Spirometry showed a significant decrease in dynamic lung volumes ( forced expiratory volume in 1 second and forced vital capacity ; p < 0.05 ) with the paralyzed hemidiaphragm . Blood oxygen saturation levels did not change significantly . CONCLUSIONS Our results show that phrenic nerve palsy causes a significant impairment of dynamic lung volumes during the early postoperative period after pneumonectomy . Therefore , in these already compromised patients , intraoperative phrenic nerve injury should be avoided whenever possible . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Other, Intervention_Surgical, Participant_Condition, Participant_Sample-size

[ "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Surgical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Effect of phrenic nerve palsy on early postoperative lung function after pneumonectomy : a prospective study . BACKGROUND The issue of phrenic nerve preservation during pneumonectomy is still an unanswered question . So far , its direct effect on immediate postoperative pulmonary lung function has never been evaluated in a prospective trial . METHODS We conducted a prospective crossover study including 10 patients undergoing pneumonectomy for lung cancer between July 2011 and July 2012 . After written informed consent , all consecutive patients who agreed to take part in the study and in whom preservation of the phrenic nerve during operation was possible , were included in the study . Upon completion of lung resection , a catheter was placed in the proximal paraphrenic tissue on the pericardial surface . After an initial phase of recovery of 5 days all patients underwent ultrasonographic assessment of diaphragmatic motion followed by lung function testing with and without induced phrenic nerve palsy . The controlled , temporary paralysis of the ipsilateral hemidiaphragm was achieved by local administration of lidocaine 1 % at a rate of 3 mL/h ( 30 mg/h ) via the above-mentioned catheter . RESULTS Temporary phrenic nerve palsy was accomplished in all but 1 patient with suspected catheter dislocation . Spirometry showed a significant decrease in dynamic lung volumes ( forced expiratory volume in 1 second and forced vital capacity ; p < 0.05 ) with the paralyzed hemidiaphragm . Blood oxygen saturation levels did not change significantly . CONCLUSIONS Our results show that phrenic nerve palsy causes a significant impairment of dynamic lung volumes during the early postoperative period after pneumonectomy . Therefore , in these already compromised patients , intraoperative phrenic nerve injury should be avoided whenever possible .

[ "Effect", "of", "phrenic", "nerve", "palsy", "on", "early", "postoperative", "lung", "function", "after", "pneumonectomy", ":", "a", "prospective", "study", ".", "BACKGROUND", "The", "issue", "of", "phrenic", "nerve", "preservation", "during", "pneumonectomy", "is", "still", "an", "unanswered", "question", ".", "So", "far", ",", "its", "direct", "effect", "on", "immediate", "postoperative", "pulmonary", "lung", "function", "has", "never", "been", "evaluated", "in", "a", "prospective", "trial", ".", "METHODS", "We", "conducted", "a", "prospective", "crossover", "study", "including", "10", "patients", "undergoing", "pneumonectomy", "for", "lung", "cancer", "between", "July", "2011", "and", "July", "2012", ".", "After", "written", "informed", "consent", ",", "all", "consecutive", "patients", "who", "agreed", "to", "take", "part", "in", "the", "study", "and", "in", "whom", "preservation", "of", "the", "phrenic", "nerve", "during", "operation", "was", "possible", ",", "were", "included", "in", "the", "study", ".", "Upon", "completion", "of", "lung", "resection", ",", "a", "catheter", "was", "placed", "in", "the", "proximal", "paraphrenic", "tissue", "on", "the", "pericardial", "surface", ".", "After", "an", "initial", "phase", "of", "recovery", "of", "5", "days", "all", "patients", "underwent", "ultrasonographic", "assessment", "of", "diaphragmatic", "motion", "followed", "by", "lung", "function", "testing", "with", "and", "without", "induced", "phrenic", "nerve", "palsy", ".", "The", "controlled", ",", "temporary", "paralysis", "of", "the", "ipsilateral", "hemidiaphragm", "was", "achieved", "by", "local", "administration", "of", "lidocaine", "1", "%", "at", "a", "rate", "of", "3", "mL", "/", "h", "(", "30", "mg", "/", "h", ")", "via", "the", "above", "-", "mentioned", "catheter", ".", "RESULTS", "Temporary", "phrenic", "nerve", "palsy", "was", "accomplished", "in", "all", "but", "1", "patient", "with", "suspected", "catheter", "dislocation", ".", "Spirometry", "showed", "a", "significant", "decrease", "in", "dynamic", "lung", "volumes", "(", "forced", "expiratory", "volume", "in", "1", "second", "and", "forced", "vital", "capacity", ";", "p", "<", "0.05", ")", "with", "the", "paralyzed", "hemidiaphragm", ".", "Blood", "oxygen", "saturation", "levels", "did", "not", "change", "significantly", ".", "CONCLUSIONS", "Our", "results", "show", "that", "phrenic", "nerve", "palsy", "causes", "a", "significant", "impairment", "of", "dynamic", "lung", "volumes", "during", "the", "early", "postoperative", "period", "after", "pneumonectomy", ".", "Therefore", ",", "in", "these", "already", "compromised", "patients", ",", "intraoperative", "phrenic", "nerve", "injury", "should", "be", "avoided", "whenever", "possible", "." ]

[ "Intervention_Other", "Intervention_Surgical", "Participant_Condition", "Participant_Sample-size" ]

phrenic nerve is a Participant_Condition, pneumonectomy is a Intervention_Surgical, 10 is a Participant_Sample-size, lung cancer is a Participant_Condition, ultrasonographic is a Intervention_Other

61358_task1

Sentence: Effect of phrenic nerve palsy on early postoperative lung function after pneumonectomy : a prospective study . BACKGROUND The issue of phrenic nerve preservation during pneumonectomy is still an unanswered question . So far , its direct effect on immediate postoperative pulmonary lung function has never been evaluated in a prospective trial . METHODS We conducted a prospective crossover study including 10 patients undergoing pneumonectomy for lung cancer between July 2011 and July 2012 . After written informed consent , all consecutive patients who agreed to take part in the study and in whom preservation of the phrenic nerve during operation was possible , were included in the study . Upon completion of lung resection , a catheter was placed in the proximal paraphrenic tissue on the pericardial surface . After an initial phase of recovery of 5 days all patients underwent ultrasonographic assessment of diaphragmatic motion followed by lung function testing with and without induced phrenic nerve palsy . The controlled , temporary paralysis of the ipsilateral hemidiaphragm was achieved by local administration of lidocaine 1 % at a rate of 3 mL/h ( 30 mg/h ) via the above-mentioned catheter . RESULTS Temporary phrenic nerve palsy was accomplished in all but 1 patient with suspected catheter dislocation . Spirometry showed a significant decrease in dynamic lung volumes ( forced expiratory volume in 1 second and forced vital capacity ; p < 0.05 ) with the paralyzed hemidiaphragm . Blood oxygen saturation levels did not change significantly . CONCLUSIONS Our results show that phrenic nerve palsy causes a significant impairment of dynamic lung volumes during the early postoperative period after pneumonectomy . Therefore , in these already compromised patients , intraoperative phrenic nerve injury should be avoided whenever possible . Instructions: please typing these entity words according to sentence: phrenic nerve, pneumonectomy, 10, lung cancer, ultrasonographic Options: Intervention_Other, Intervention_Surgical, Participant_Condition, Participant_Sample-size

[ "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Surgical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Effect of phrenic nerve palsy on early postoperative lung function after pneumonectomy : a prospective study . BACKGROUND The issue of phrenic nerve preservation during pneumonectomy is still an unanswered question . So far , its direct effect on immediate postoperative pulmonary lung function has never been evaluated in a prospective trial . METHODS We conducted a prospective crossover study including 10 patients undergoing pneumonectomy for lung cancer between July 2011 and July 2012 . After written informed consent , all consecutive patients who agreed to take part in the study and in whom preservation of the phrenic nerve during operation was possible , were included in the study . Upon completion of lung resection , a catheter was placed in the proximal paraphrenic tissue on the pericardial surface . After an initial phase of recovery of 5 days all patients underwent ultrasonographic assessment of diaphragmatic motion followed by lung function testing with and without induced phrenic nerve palsy . The controlled , temporary paralysis of the ipsilateral hemidiaphragm was achieved by local administration of lidocaine 1 % at a rate of 3 mL/h ( 30 mg/h ) via the above-mentioned catheter . RESULTS Temporary phrenic nerve palsy was accomplished in all but 1 patient with suspected catheter dislocation . Spirometry showed a significant decrease in dynamic lung volumes ( forced expiratory volume in 1 second and forced vital capacity ; p < 0.05 ) with the paralyzed hemidiaphragm . Blood oxygen saturation levels did not change significantly . CONCLUSIONS Our results show that phrenic nerve palsy causes a significant impairment of dynamic lung volumes during the early postoperative period after pneumonectomy . Therefore , in these already compromised patients , intraoperative phrenic nerve injury should be avoided whenever possible .

[ "Effect", "of", "phrenic", "nerve", "palsy", "on", "early", "postoperative", "lung", "function", "after", "pneumonectomy", ":", "a", "prospective", "study", ".", "BACKGROUND", "The", "issue", "of", "phrenic", "nerve", "preservation", "during", "pneumonectomy", "is", "still", "an", "unanswered", "question", ".", "So", "far", ",", "its", "direct", "effect", "on", "immediate", "postoperative", "pulmonary", "lung", "function", "has", "never", "been", "evaluated", "in", "a", "prospective", "trial", ".", "METHODS", "We", "conducted", "a", "prospective", "crossover", "study", "including", "10", "patients", "undergoing", "pneumonectomy", "for", "lung", "cancer", "between", "July", "2011", "and", "July", "2012", ".", "After", "written", "informed", "consent", ",", "all", "consecutive", "patients", "who", "agreed", "to", "take", "part", "in", "the", "study", "and", "in", "whom", "preservation", "of", "the", "phrenic", "nerve", "during", "operation", "was", "possible", ",", "were", "included", "in", "the", "study", ".", "Upon", "completion", "of", "lung", "resection", ",", "a", "catheter", "was", "placed", "in", "the", "proximal", "paraphrenic", "tissue", "on", "the", "pericardial", "surface", ".", "After", "an", "initial", "phase", "of", "recovery", "of", "5", "days", "all", "patients", "underwent", "ultrasonographic", "assessment", "of", "diaphragmatic", "motion", "followed", "by", "lung", "function", "testing", "with", "and", "without", "induced", "phrenic", "nerve", "palsy", ".", "The", "controlled", ",", "temporary", "paralysis", "of", "the", "ipsilateral", "hemidiaphragm", "was", "achieved", "by", "local", "administration", "of", "lidocaine", "1", "%", "at", "a", "rate", "of", "3", "mL", "/", "h", "(", "30", "mg", "/", "h", ")", "via", "the", "above", "-", "mentioned", "catheter", ".", "RESULTS", "Temporary", "phrenic", "nerve", "palsy", "was", "accomplished", "in", "all", "but", "1", "patient", "with", "suspected", "catheter", "dislocation", ".", "Spirometry", "showed", "a", "significant", "decrease", "in", "dynamic", "lung", "volumes", "(", "forced", "expiratory", "volume", "in", "1", "second", "and", "forced", "vital", "capacity", ";", "p", "<", "0.05", ")", "with", "the", "paralyzed", "hemidiaphragm", ".", "Blood", "oxygen", "saturation", "levels", "did", "not", "change", "significantly", ".", "CONCLUSIONS", "Our", "results", "show", "that", "phrenic", "nerve", "palsy", "causes", "a", "significant", "impairment", "of", "dynamic", "lung", "volumes", "during", "the", "early", "postoperative", "period", "after", "pneumonectomy", ".", "Therefore", ",", "in", "these", "already", "compromised", "patients", ",", "intraoperative", "phrenic", "nerve", "injury", "should", "be", "avoided", "whenever", "possible", "." ]

[ "Intervention_Other", "Intervention_Surgical", "Participant_Condition", "Participant_Sample-size" ]

phrenic nerve, pneumonectomy, 10, lung cancer, ultrasonographic

61358_task2

Sentence: Effect of phrenic nerve palsy on early postoperative lung function after pneumonectomy : a prospective study . BACKGROUND The issue of phrenic nerve preservation during pneumonectomy is still an unanswered question . So far , its direct effect on immediate postoperative pulmonary lung function has never been evaluated in a prospective trial . METHODS We conducted a prospective crossover study including 10 patients undergoing pneumonectomy for lung cancer between July 2011 and July 2012 . After written informed consent , all consecutive patients who agreed to take part in the study and in whom preservation of the phrenic nerve during operation was possible , were included in the study . Upon completion of lung resection , a catheter was placed in the proximal paraphrenic tissue on the pericardial surface . After an initial phase of recovery of 5 days all patients underwent ultrasonographic assessment of diaphragmatic motion followed by lung function testing with and without induced phrenic nerve palsy . The controlled , temporary paralysis of the ipsilateral hemidiaphragm was achieved by local administration of lidocaine 1 % at a rate of 3 mL/h ( 30 mg/h ) via the above-mentioned catheter . RESULTS Temporary phrenic nerve palsy was accomplished in all but 1 patient with suspected catheter dislocation . Spirometry showed a significant decrease in dynamic lung volumes ( forced expiratory volume in 1 second and forced vital capacity ; p < 0.05 ) with the paralyzed hemidiaphragm . Blood oxygen saturation levels did not change significantly . CONCLUSIONS Our results show that phrenic nerve palsy causes a significant impairment of dynamic lung volumes during the early postoperative period after pneumonectomy . Therefore , in these already compromised patients , intraoperative phrenic nerve injury should be avoided whenever possible . Instructions: please extract entity words from the input sentence

[ "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Surgical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Effect of phrenic nerve palsy on early postoperative lung function after pneumonectomy : a prospective study . BACKGROUND The issue of phrenic nerve preservation during pneumonectomy is still an unanswered question . So far , its direct effect on immediate postoperative pulmonary lung function has never been evaluated in a prospective trial . METHODS We conducted a prospective crossover study including 10 patients undergoing pneumonectomy for lung cancer between July 2011 and July 2012 . After written informed consent , all consecutive patients who agreed to take part in the study and in whom preservation of the phrenic nerve during operation was possible , were included in the study . Upon completion of lung resection , a catheter was placed in the proximal paraphrenic tissue on the pericardial surface . After an initial phase of recovery of 5 days all patients underwent ultrasonographic assessment of diaphragmatic motion followed by lung function testing with and without induced phrenic nerve palsy . The controlled , temporary paralysis of the ipsilateral hemidiaphragm was achieved by local administration of lidocaine 1 % at a rate of 3 mL/h ( 30 mg/h ) via the above-mentioned catheter . RESULTS Temporary phrenic nerve palsy was accomplished in all but 1 patient with suspected catheter dislocation . Spirometry showed a significant decrease in dynamic lung volumes ( forced expiratory volume in 1 second and forced vital capacity ; p < 0.05 ) with the paralyzed hemidiaphragm . Blood oxygen saturation levels did not change significantly . CONCLUSIONS Our results show that phrenic nerve palsy causes a significant impairment of dynamic lung volumes during the early postoperative period after pneumonectomy . Therefore , in these already compromised patients , intraoperative phrenic nerve injury should be avoided whenever possible .

[ "Effect", "of", "phrenic", "nerve", "palsy", "on", "early", "postoperative", "lung", "function", "after", "pneumonectomy", ":", "a", "prospective", "study", ".", "BACKGROUND", "The", "issue", "of", "phrenic", "nerve", "preservation", "during", "pneumonectomy", "is", "still", "an", "unanswered", "question", ".", "So", "far", ",", "its", "direct", "effect", "on", "immediate", "postoperative", "pulmonary", "lung", "function", "has", "never", "been", "evaluated", "in", "a", "prospective", "trial", ".", "METHODS", "We", "conducted", "a", "prospective", "crossover", "study", "including", "10", "patients", "undergoing", "pneumonectomy", "for", "lung", "cancer", "between", "July", "2011", "and", "July", "2012", ".", "After", "written", "informed", "consent", ",", "all", "consecutive", "patients", "who", "agreed", "to", "take", "part", "in", "the", "study", "and", "in", "whom", "preservation", "of", "the", "phrenic", "nerve", "during", "operation", "was", "possible", ",", "were", "included", "in", "the", "study", ".", "Upon", "completion", "of", "lung", "resection", ",", "a", "catheter", "was", "placed", "in", "the", "proximal", "paraphrenic", "tissue", "on", "the", "pericardial", "surface", ".", "After", "an", "initial", "phase", "of", "recovery", "of", "5", "days", "all", "patients", "underwent", "ultrasonographic", "assessment", "of", "diaphragmatic", "motion", "followed", "by", "lung", "function", "testing", "with", "and", "without", "induced", "phrenic", "nerve", "palsy", ".", "The", "controlled", ",", "temporary", "paralysis", "of", "the", "ipsilateral", "hemidiaphragm", "was", "achieved", "by", "local", "administration", "of", "lidocaine", "1", "%", "at", "a", "rate", "of", "3", "mL", "/", "h", "(", "30", "mg", "/", "h", ")", "via", "the", "above", "-", "mentioned", "catheter", ".", "RESULTS", "Temporary", "phrenic", "nerve", "palsy", "was", "accomplished", "in", "all", "but", "1", "patient", "with", "suspected", "catheter", "dislocation", ".", "Spirometry", "showed", "a", "significant", "decrease", "in", "dynamic", "lung", "volumes", "(", "forced", "expiratory", "volume", "in", "1", "second", "and", "forced", "vital", "capacity", ";", "p", "<", "0.05", ")", "with", "the", "paralyzed", "hemidiaphragm", ".", "Blood", "oxygen", "saturation", "levels", "did", "not", "change", "significantly", ".", "CONCLUSIONS", "Our", "results", "show", "that", "phrenic", "nerve", "palsy", "causes", "a", "significant", "impairment", "of", "dynamic", "lung", "volumes", "during", "the", "early", "postoperative", "period", "after", "pneumonectomy", ".", "Therefore", ",", "in", "these", "already", "compromised", "patients", ",", "intraoperative", "phrenic", "nerve", "injury", "should", "be", "avoided", "whenever", "possible", "." ]

[ "Intervention_Other", "Intervention_Surgical", "Participant_Condition", "Participant_Sample-size" ]

gelsolin is a Individual_protein, profilin is a Individual_protein, actin is a Individual_protein

546_task0

Sentence: The colocalization of gelsolin and profilin in motile, microfilament-rich areas supports the hypothesis that they synergistically regulate the actin dynamics that underlie neurite growth. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Individual_protein

[ "O", "O", "O", "B-Individual_protein", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O" ]

The colocalization of gelsolin and profilin in motile, microfilament-rich areas supports the hypothesis that they synergistically regulate the actin dynamics that underlie neurite growth.

[ "The", "colocalization", "of", "gelsolin", "and", "profilin", "in", "motile", ",", "microfilament", "-", "rich", "areas", "supports", "the", "hypothesis", "that", "they", "synergistically", "regulate", "the", "actin", "dynamics", "that", "underlie", "neurite", "growth", "." ]

[ "Individual_protein" ]

gelsolin is a Individual_protein, profilin is a Individual_protein, actin is a Individual_protein

546_task1

Sentence: The colocalization of gelsolin and profilin in motile, microfilament-rich areas supports the hypothesis that they synergistically regulate the actin dynamics that underlie neurite growth. Instructions: please typing these entity words according to sentence: gelsolin, profilin, actin Options: Individual_protein

[ "O", "O", "O", "B-Individual_protein", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O" ]

The colocalization of gelsolin and profilin in motile, microfilament-rich areas supports the hypothesis that they synergistically regulate the actin dynamics that underlie neurite growth.

[ "The", "colocalization", "of", "gelsolin", "and", "profilin", "in", "motile", ",", "microfilament", "-", "rich", "areas", "supports", "the", "hypothesis", "that", "they", "synergistically", "regulate", "the", "actin", "dynamics", "that", "underlie", "neurite", "growth", "." ]

[ "Individual_protein" ]

gelsolin, profilin, actin

546_task2

Sentence: The colocalization of gelsolin and profilin in motile, microfilament-rich areas supports the hypothesis that they synergistically regulate the actin dynamics that underlie neurite growth. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "B-Individual_protein", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O" ]

The colocalization of gelsolin and profilin in motile, microfilament-rich areas supports the hypothesis that they synergistically regulate the actin dynamics that underlie neurite growth.

[ "The", "colocalization", "of", "gelsolin", "and", "profilin", "in", "motile", ",", "microfilament", "-", "rich", "areas", "supports", "the", "hypothesis", "that", "they", "synergistically", "regulate", "the", "actin", "dynamics", "that", "underlie", "neurite", "growth", "." ]

[ "Individual_protein" ]

Pregnancy is a Condition, breast feeding is a Observation, Estimated life expectancy is a Observation, < 12 months is a Value, Scheduled is a Mood, major surgery is a Procedure, in the next 6 months is a Temporal, Inability to follow the protocol is a Observation, Previous is a Temporal, enrolment in this study is a Observation, treatment with an investigational drug is a Procedure, device is a Device, WHO is a Measurement, group II , III , IV , V is a Value, PH is a Condition, Severe Renal dysfunction is a Scope, Systematical inflammation is a Condition, Tricuspid valve stenosis is a Condition, Supra - pulmonary valve stenosis is a Condition, Allergic is a Condition, studied drugs or metal materials is a Scope

NCT02284737_exc_task0

Sentence: Pregnancy and breast feeding mother; Estimated life expectancy <12 months; Scheduled major surgery in the next 6 months; Inability to follow the protocol and comply with follow-up requirements or any other reason that the investigator feels would place the patient at increased risk; Previous enrolment in this study or treatment with an investigational drug or device under another study protocol in the past 30 days. WHO group II, III, IV, V PH Severe Renal dysfunction (Ccr<30 ml/min) Blood platelet count<100,000/L Expected life span<6-month Systematical inflammation Malignant cancer(s) Tricuspid valve stenosis, Supra-pulmonary valve stenosis Allergic to studied drugs or metal materials. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Temporal, Condition, Measurement, Value, Observation, Procedure, Scope, Device, Mood

[ "B-Condition", "O", "B-Observation", "I-Observation", "O", "O", "O", "B-Observation", "I-Observation", "I-Observation", "B-Value", "I-Value", "I-Value", "O", "O", "B-Mood", "B-Procedure", "I-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "B-Device", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O" ]

Pregnancy and breast feeding mother; Estimated life expectancy <12 months; Scheduled major surgery in the next 6 months; Inability to follow the protocol and comply with follow-up requirements or any other reason that the investigator feels would place the patient at increased risk; Previous enrolment in this study or treatment with an investigational drug or device under another study protocol in the past 30 days. WHO group II, III, IV, V PH Severe Renal dysfunction (Ccr<30 ml/min) Blood platelet count<100,000/L Expected life span<6-month Systematical inflammation Malignant cancer(s) Tricuspid valve stenosis, Supra-pulmonary valve stenosis Allergic to studied drugs or metal materials.

[ "Pregnancy", "and", "breast", "feeding", "mother", ";", "\n", "Estimated", "life", "expectancy", "<", "12", "months", ";", "\n", "Scheduled", "major", "surgery", "in", "the", "next", "6", "months", ";", "\n", "Inability", "to", "follow", "the", "protocol", "and", "comply", "with", "follow", "-", "up", "requirements", "or", "any", "other", "reason", "that", "the", "investigator", "feels", "would", "place", "the", "patient", "at", "increased", "risk", ";", "\n", "Previous", "enrolment", "in", "this", "study", "or", "treatment", "with", "an", "investigational", "drug", "or", "device", "under", "another", "study", "protocol", "in", "the", "past", "30", "days", ".", "\n", "WHO", "group", "II", ",", "III", ",", "IV", ",", "V", "PH", "\n", "Severe", "Renal", "dysfunction", "(", "Ccr<30", "ml", "/", "min", ")", "\n", "Blood", "platelet", "count<100,000", "/", "L", "\n", "Expected", "life", "span<6-month", "\n", "Systematical", "inflammation", "\n", "Malignant", "cancer(s", ")", "\n", "Tricuspid", "valve", "stenosis", ",", "Supra", "-", "pulmonary", "valve", "stenosis", "\n", "Allergic", "to", "studied", "drugs", "or", "metal", "materials", ".", "\n" ]

[ "Procedure", "Scope", "Observation", "Condition", "Temporal", "Value", "Measurement", "Drug", "Mood", "Qualifier", "Device" ]

Pregnancy is a Condition, breast feeding is a Observation, Estimated life expectancy is a Observation, < 12 months is a Value, Scheduled is a Mood, major surgery is a Procedure, in the next 6 months is a Temporal, Inability to follow the protocol is a Observation, Previous is a Temporal, enrolment in this study is a Observation, treatment with an investigational drug is a Procedure, device is a Device, WHO is a Measurement, group II , III , IV , V is a Value, PH is a Condition, Severe Renal dysfunction is a Scope, Systematical inflammation is a Condition, Tricuspid valve stenosis is a Condition, Supra - pulmonary valve stenosis is a Condition, Allergic is a Condition, studied drugs or metal materials is a Scope

NCT02284737_exc_task1

Sentence: Pregnancy and breast feeding mother; Estimated life expectancy <12 months; Scheduled major surgery in the next 6 months; Inability to follow the protocol and comply with follow-up requirements or any other reason that the investigator feels would place the patient at increased risk; Previous enrolment in this study or treatment with an investigational drug or device under another study protocol in the past 30 days. WHO group II, III, IV, V PH Severe Renal dysfunction (Ccr<30 ml/min) Blood platelet count<100,000/L Expected life span<6-month Systematical inflammation Malignant cancer(s) Tricuspid valve stenosis, Supra-pulmonary valve stenosis Allergic to studied drugs or metal materials. Instructions: please typing these entity words according to sentence: Pregnancy, breast feeding, Estimated life expectancy, < 12 months, Scheduled, major surgery, in the next 6 months, Inability to follow the protocol, Previous, enrolment in this study, treatment with an investigational drug, device, WHO, group II , III , IV , V, PH, Severe Renal dysfunction, Systematical inflammation, Tricuspid valve stenosis, Supra - pulmonary valve stenosis, Allergic, studied drugs or metal materials Options: Temporal, Condition, Measurement, Value, Observation, Procedure, Scope, Device, Mood

[ "B-Condition", "O", "B-Observation", "I-Observation", "O", "O", "O", "B-Observation", "I-Observation", "I-Observation", "B-Value", "I-Value", "I-Value", "O", "O", "B-Mood", "B-Procedure", "I-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "B-Device", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O" ]

Pregnancy and breast feeding mother; Estimated life expectancy <12 months; Scheduled major surgery in the next 6 months; Inability to follow the protocol and comply with follow-up requirements or any other reason that the investigator feels would place the patient at increased risk; Previous enrolment in this study or treatment with an investigational drug or device under another study protocol in the past 30 days. WHO group II, III, IV, V PH Severe Renal dysfunction (Ccr<30 ml/min) Blood platelet count<100,000/L Expected life span<6-month Systematical inflammation Malignant cancer(s) Tricuspid valve stenosis, Supra-pulmonary valve stenosis Allergic to studied drugs or metal materials.

[ "Pregnancy", "and", "breast", "feeding", "mother", ";", "\n", "Estimated", "life", "expectancy", "<", "12", "months", ";", "\n", "Scheduled", "major", "surgery", "in", "the", "next", "6", "months", ";", "\n", "Inability", "to", "follow", "the", "protocol", "and", "comply", "with", "follow", "-", "up", "requirements", "or", "any", "other", "reason", "that", "the", "investigator", "feels", "would", "place", "the", "patient", "at", "increased", "risk", ";", "\n", "Previous", "enrolment", "in", "this", "study", "or", "treatment", "with", "an", "investigational", "drug", "or", "device", "under", "another", "study", "protocol", "in", "the", "past", "30", "days", ".", "\n", "WHO", "group", "II", ",", "III", ",", "IV", ",", "V", "PH", "\n", "Severe", "Renal", "dysfunction", "(", "Ccr<30", "ml", "/", "min", ")", "\n", "Blood", "platelet", "count<100,000", "/", "L", "\n", "Expected", "life", "span<6-month", "\n", "Systematical", "inflammation", "\n", "Malignant", "cancer(s", ")", "\n", "Tricuspid", "valve", "stenosis", ",", "Supra", "-", "pulmonary", "valve", "stenosis", "\n", "Allergic", "to", "studied", "drugs", "or", "metal", "materials", ".", "\n" ]

[ "Procedure", "Scope", "Observation", "Condition", "Temporal", "Value", "Measurement", "Drug", "Mood", "Qualifier", "Device" ]

Pregnancy, breast feeding, Estimated life expectancy, < 12 months, Scheduled, major surgery, in the next 6 months, Inability to follow the protocol, Previous, enrolment in this study, treatment with an investigational drug, device, WHO, group II , III , IV , V, PH, Severe Renal dysfunction, Systematical inflammation, Tricuspid valve stenosis, Supra - pulmonary valve stenosis, Allergic, studied drugs or metal materials

NCT02284737_exc_task2

Sentence: Pregnancy and breast feeding mother; Estimated life expectancy <12 months; Scheduled major surgery in the next 6 months; Inability to follow the protocol and comply with follow-up requirements or any other reason that the investigator feels would place the patient at increased risk; Previous enrolment in this study or treatment with an investigational drug or device under another study protocol in the past 30 days. WHO group II, III, IV, V PH Severe Renal dysfunction (Ccr<30 ml/min) Blood platelet count<100,000/L Expected life span<6-month Systematical inflammation Malignant cancer(s) Tricuspid valve stenosis, Supra-pulmonary valve stenosis Allergic to studied drugs or metal materials. Instructions: please extract entity words from the input sentence

[ "B-Condition", "O", "B-Observation", "I-Observation", "O", "O", "O", "B-Observation", "I-Observation", "I-Observation", "B-Value", "I-Value", "I-Value", "O", "O", "B-Mood", "B-Procedure", "I-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Temporal", "B-Observation", "I-Observation", "I-Observation", "I-Observation", "O", "B-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "I-Procedure", "O", "B-Device", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "B-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "O", "O", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O" ]

Pregnancy and breast feeding mother; Estimated life expectancy <12 months; Scheduled major surgery in the next 6 months; Inability to follow the protocol and comply with follow-up requirements or any other reason that the investigator feels would place the patient at increased risk; Previous enrolment in this study or treatment with an investigational drug or device under another study protocol in the past 30 days. WHO group II, III, IV, V PH Severe Renal dysfunction (Ccr<30 ml/min) Blood platelet count<100,000/L Expected life span<6-month Systematical inflammation Malignant cancer(s) Tricuspid valve stenosis, Supra-pulmonary valve stenosis Allergic to studied drugs or metal materials.

[ "Pregnancy", "and", "breast", "feeding", "mother", ";", "\n", "Estimated", "life", "expectancy", "<", "12", "months", ";", "\n", "Scheduled", "major", "surgery", "in", "the", "next", "6", "months", ";", "\n", "Inability", "to", "follow", "the", "protocol", "and", "comply", "with", "follow", "-", "up", "requirements", "or", "any", "other", "reason", "that", "the", "investigator", "feels", "would", "place", "the", "patient", "at", "increased", "risk", ";", "\n", "Previous", "enrolment", "in", "this", "study", "or", "treatment", "with", "an", "investigational", "drug", "or", "device", "under", "another", "study", "protocol", "in", "the", "past", "30", "days", ".", "\n", "WHO", "group", "II", ",", "III", ",", "IV", ",", "V", "PH", "\n", "Severe", "Renal", "dysfunction", "(", "Ccr<30", "ml", "/", "min", ")", "\n", "Blood", "platelet", "count<100,000", "/", "L", "\n", "Expected", "life", "span<6-month", "\n", "Systematical", "inflammation", "\n", "Malignant", "cancer(s", ")", "\n", "Tricuspid", "valve", "stenosis", ",", "Supra", "-", "pulmonary", "valve", "stenosis", "\n", "Allergic", "to", "studied", "drugs", "or", "metal", "materials", ".", "\n" ]

[ "Procedure", "Scope", "Observation", "Condition", "Temporal", "Value", "Measurement", "Drug", "Mood", "Qualifier", "Device" ]

Medikamente is an umlsterm, Blutfluss is an umlsterm, Blutflussveraenderungen is an umlsterm, Uvea is an umlsterm, Literatur is an umlsterm, Blutfluss is an umlsterm, Augenpols is an umlsterm, Zeit is an umlsterm, Placebo - kontrollierte is an umlsterm, Blutfluss is an umlsterm

DerOpthalmologe.90960706.ger.abstr_task0

Sentence: Hintergrund : Viele der antiglaukomatoesen Medikamente beeinflussen den okulaeren Blutfluss . Die Blutflussveraenderungen in der vorderen Uvea sind in der Literatur beschrieben . Ueber den Effekt von Antiglaukomatosa auf den Blutfluss des hinteren Augenpols wird in neuerer Zeit vermehrt berichtet . Wir praesentieren eine Placebo-kontrollierte Studie mit Blick auf den kurz- und mittelfristigen Einfluss von topisch appliziertem Dipivefrin 0,1 % auf den retinalen und papillaeren Blutfluss . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

Hintergrund : Viele der antiglaukomatoesen Medikamente beeinflussen den okulaeren Blutfluss . Die Blutflussveraenderungen in der vorderen Uvea sind in der Literatur beschrieben . Ueber den Effekt von Antiglaukomatosa auf den Blutfluss des hinteren Augenpols wird in neuerer Zeit vermehrt berichtet . Wir praesentieren eine Placebo-kontrollierte Studie mit Blick auf den kurz- und mittelfristigen Einfluss von topisch appliziertem Dipivefrin 0,1 % auf den retinalen und papillaeren Blutfluss .

[ "Hintergrund", ":", "Viele", "der", "antiglaukomatoesen", "Medikamente", "beeinflussen", "den", "okulaeren", "Blutfluss", ".", "Die", "Blutflussveraenderungen", "in", "der", "vorderen", "Uvea", "sind", "in", "der", "Literatur", "beschrieben", ".", "Ueber", "den", "Effekt", "von", "Antiglaukomatosa", "auf", "den", "Blutfluss", "des", "hinteren", "Augenpols", "wird", "in", "neuerer", "Zeit", "vermehrt", "berichtet", ".", "Wir", "praesentieren", "eine", "Placebo", "-", "kontrollierte", "Studie", "mit", "Blick", "auf", "den", "kurz-", "und", "mittelfristigen", "Einfluss", "von", "topisch", "appliziertem", "Dipivefrin", "0,1", "%", "auf", "den", "retinalen", "und", "papillaeren", "Blutfluss", "." ]

[ "umlsterm" ]

Medikamente is an umlsterm, Blutfluss is an umlsterm, Blutflussveraenderungen is an umlsterm, Uvea is an umlsterm, Literatur is an umlsterm, Blutfluss is an umlsterm, Augenpols is an umlsterm, Zeit is an umlsterm, Placebo - kontrollierte is an umlsterm, Blutfluss is an umlsterm

DerOpthalmologe.90960706.ger.abstr_task1

Sentence: Hintergrund : Viele der antiglaukomatoesen Medikamente beeinflussen den okulaeren Blutfluss . Die Blutflussveraenderungen in der vorderen Uvea sind in der Literatur beschrieben . Ueber den Effekt von Antiglaukomatosa auf den Blutfluss des hinteren Augenpols wird in neuerer Zeit vermehrt berichtet . Wir praesentieren eine Placebo-kontrollierte Studie mit Blick auf den kurz- und mittelfristigen Einfluss von topisch appliziertem Dipivefrin 0,1 % auf den retinalen und papillaeren Blutfluss . Instructions: please typing these entity words according to sentence: Medikamente, Blutfluss, Blutflussveraenderungen, Uvea, Literatur, Blutfluss, Augenpols, Zeit, Placebo - kontrollierte, Blutfluss Options: umlsterm

[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

Hintergrund : Viele der antiglaukomatoesen Medikamente beeinflussen den okulaeren Blutfluss . Die Blutflussveraenderungen in der vorderen Uvea sind in der Literatur beschrieben . Ueber den Effekt von Antiglaukomatosa auf den Blutfluss des hinteren Augenpols wird in neuerer Zeit vermehrt berichtet . Wir praesentieren eine Placebo-kontrollierte Studie mit Blick auf den kurz- und mittelfristigen Einfluss von topisch appliziertem Dipivefrin 0,1 % auf den retinalen und papillaeren Blutfluss .

[ "Hintergrund", ":", "Viele", "der", "antiglaukomatoesen", "Medikamente", "beeinflussen", "den", "okulaeren", "Blutfluss", ".", "Die", "Blutflussveraenderungen", "in", "der", "vorderen", "Uvea", "sind", "in", "der", "Literatur", "beschrieben", ".", "Ueber", "den", "Effekt", "von", "Antiglaukomatosa", "auf", "den", "Blutfluss", "des", "hinteren", "Augenpols", "wird", "in", "neuerer", "Zeit", "vermehrt", "berichtet", ".", "Wir", "praesentieren", "eine", "Placebo", "-", "kontrollierte", "Studie", "mit", "Blick", "auf", "den", "kurz-", "und", "mittelfristigen", "Einfluss", "von", "topisch", "appliziertem", "Dipivefrin", "0,1", "%", "auf", "den", "retinalen", "und", "papillaeren", "Blutfluss", "." ]

[ "umlsterm" ]

Medikamente, Blutfluss, Blutflussveraenderungen, Uvea, Literatur, Blutfluss, Augenpols, Zeit, Placebo - kontrollierte, Blutfluss

DerOpthalmologe.90960706.ger.abstr_task2

Sentence: Hintergrund : Viele der antiglaukomatoesen Medikamente beeinflussen den okulaeren Blutfluss . Die Blutflussveraenderungen in der vorderen Uvea sind in der Literatur beschrieben . Ueber den Effekt von Antiglaukomatosa auf den Blutfluss des hinteren Augenpols wird in neuerer Zeit vermehrt berichtet . Wir praesentieren eine Placebo-kontrollierte Studie mit Blick auf den kurz- und mittelfristigen Einfluss von topisch appliziertem Dipivefrin 0,1 % auf den retinalen und papillaeren Blutfluss . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

Hintergrund : Viele der antiglaukomatoesen Medikamente beeinflussen den okulaeren Blutfluss . Die Blutflussveraenderungen in der vorderen Uvea sind in der Literatur beschrieben . Ueber den Effekt von Antiglaukomatosa auf den Blutfluss des hinteren Augenpols wird in neuerer Zeit vermehrt berichtet . Wir praesentieren eine Placebo-kontrollierte Studie mit Blick auf den kurz- und mittelfristigen Einfluss von topisch appliziertem Dipivefrin 0,1 % auf den retinalen und papillaeren Blutfluss .

[ "Hintergrund", ":", "Viele", "der", "antiglaukomatoesen", "Medikamente", "beeinflussen", "den", "okulaeren", "Blutfluss", ".", "Die", "Blutflussveraenderungen", "in", "der", "vorderen", "Uvea", "sind", "in", "der", "Literatur", "beschrieben", ".", "Ueber", "den", "Effekt", "von", "Antiglaukomatosa", "auf", "den", "Blutfluss", "des", "hinteren", "Augenpols", "wird", "in", "neuerer", "Zeit", "vermehrt", "berichtet", ".", "Wir", "praesentieren", "eine", "Placebo", "-", "kontrollierte", "Studie", "mit", "Blick", "auf", "den", "kurz-", "und", "mittelfristigen", "Einfluss", "von", "topisch", "appliziertem", "Dipivefrin", "0,1", "%", "auf", "den", "retinalen", "und", "papillaeren", "Blutfluss", "." ]

[ "umlsterm" ]

syndrome is an umlsterm, fibromas is an umlsterm, colonic polyps is an umlsterm, literature is an umlsterm, fibromas is an umlsterm, mother is an umlsterm, daughter is an umlsterm, mother is an umlsterm, colonic polyps is an umlsterm, syndrome is an umlsterm, syndrome is an umlsterm, syndrome is an umlsterm, fibromas is an umlsterm, sequelae is an umlsterm, acne is an umlsterm, patient is an umlsterm, colonic polyps is an umlsterm, cancer is an umlsterm, screening is an umlsterm

DerHautarzt.60470304.eng.abstr_task0

Sentence: The syndrome of perifollicular fibromas and colonic polyps was delineated 20 years ago by Hornstein and Knickenberg ; it probably occurs more frequently than suggested by the literature . Multiple perifollicular fibromas were found in a mother and daughter . The mother also had colonic polyps . This dermo-intestinal syndrome varies in its clinical manifestations , but it is probably an autosomal dominant trait . We believe that the Hornstein-Knickenberg syndrome and the Birt-Hogg-Dubé syndrome are identical . If perifollicular fibromas are observed and cannot be explained as postinflammatory sequelae of acne , the patient should be examined for colonic polyps as an appropriate form of cancer screening . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O" ]

The syndrome of perifollicular fibromas and colonic polyps was delineated 20 years ago by Hornstein and Knickenberg ; it probably occurs more frequently than suggested by the literature . Multiple perifollicular fibromas were found in a mother and daughter . The mother also had colonic polyps . This dermo-intestinal syndrome varies in its clinical manifestations , but it is probably an autosomal dominant trait . We believe that the Hornstein-Knickenberg syndrome and the Birt-Hogg-Dubé syndrome are identical . If perifollicular fibromas are observed and cannot be explained as postinflammatory sequelae of acne , the patient should be examined for colonic polyps as an appropriate form of cancer screening .

[ "The", "syndrome", "of", "perifollicular", "fibromas", "and", "colonic", "polyps", "was", "delineated", "20", "years", "ago", "by", "Hornstein", "and", "Knickenberg", ";", "it", "probably", "occurs", "more", "frequently", "than", "suggested", "by", "the", "literature", ".", "Multiple", "perifollicular", "fibromas", "were", "found", "in", "a", "mother", "and", "daughter", ".", "The", "mother", "also", "had", "colonic", "polyps", ".", "This", "dermo", "-", "intestinal", "syndrome", "varies", "in", "its", "clinical", "manifestations", ",", "but", "it", "is", "probably", "an", "autosomal", "dominant", "trait", ".", "We", "believe", "that", "the", "Hornstein", "-", "Knickenberg", "syndrome", "and", "the", "Birt", "-", "Hogg", "-", "Dubé", "syndrome", "are", "identical", ".", "If", "perifollicular", "fibromas", "are", "observed", "and", "cannot", "be", "explained", "as", "postinflammatory", "sequelae", "of", "acne", ",", "the", "patient", "should", "be", "examined", "for", "colonic", "polyps", "as", "an", "appropriate", "form", "of", "cancer", "screening", "." ]

[ "umlsterm" ]

syndrome is an umlsterm, fibromas is an umlsterm, colonic polyps is an umlsterm, literature is an umlsterm, fibromas is an umlsterm, mother is an umlsterm, daughter is an umlsterm, mother is an umlsterm, colonic polyps is an umlsterm, syndrome is an umlsterm, syndrome is an umlsterm, syndrome is an umlsterm, fibromas is an umlsterm, sequelae is an umlsterm, acne is an umlsterm, patient is an umlsterm, colonic polyps is an umlsterm, cancer is an umlsterm, screening is an umlsterm

DerHautarzt.60470304.eng.abstr_task1

Sentence: The syndrome of perifollicular fibromas and colonic polyps was delineated 20 years ago by Hornstein and Knickenberg ; it probably occurs more frequently than suggested by the literature . Multiple perifollicular fibromas were found in a mother and daughter . The mother also had colonic polyps . This dermo-intestinal syndrome varies in its clinical manifestations , but it is probably an autosomal dominant trait . We believe that the Hornstein-Knickenberg syndrome and the Birt-Hogg-Dubé syndrome are identical . If perifollicular fibromas are observed and cannot be explained as postinflammatory sequelae of acne , the patient should be examined for colonic polyps as an appropriate form of cancer screening . Instructions: please typing these entity words according to sentence: syndrome, fibromas, colonic polyps, literature, fibromas, mother, daughter, mother, colonic polyps, syndrome, syndrome, syndrome, fibromas, sequelae, acne, patient, colonic polyps, cancer, screening Options: umlsterm

[ "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O" ]

The syndrome of perifollicular fibromas and colonic polyps was delineated 20 years ago by Hornstein and Knickenberg ; it probably occurs more frequently than suggested by the literature . Multiple perifollicular fibromas were found in a mother and daughter . The mother also had colonic polyps . This dermo-intestinal syndrome varies in its clinical manifestations , but it is probably an autosomal dominant trait . We believe that the Hornstein-Knickenberg syndrome and the Birt-Hogg-Dubé syndrome are identical . If perifollicular fibromas are observed and cannot be explained as postinflammatory sequelae of acne , the patient should be examined for colonic polyps as an appropriate form of cancer screening .

[ "The", "syndrome", "of", "perifollicular", "fibromas", "and", "colonic", "polyps", "was", "delineated", "20", "years", "ago", "by", "Hornstein", "and", "Knickenberg", ";", "it", "probably", "occurs", "more", "frequently", "than", "suggested", "by", "the", "literature", ".", "Multiple", "perifollicular", "fibromas", "were", "found", "in", "a", "mother", "and", "daughter", ".", "The", "mother", "also", "had", "colonic", "polyps", ".", "This", "dermo", "-", "intestinal", "syndrome", "varies", "in", "its", "clinical", "manifestations", ",", "but", "it", "is", "probably", "an", "autosomal", "dominant", "trait", ".", "We", "believe", "that", "the", "Hornstein", "-", "Knickenberg", "syndrome", "and", "the", "Birt", "-", "Hogg", "-", "Dubé", "syndrome", "are", "identical", ".", "If", "perifollicular", "fibromas", "are", "observed", "and", "cannot", "be", "explained", "as", "postinflammatory", "sequelae", "of", "acne", ",", "the", "patient", "should", "be", "examined", "for", "colonic", "polyps", "as", "an", "appropriate", "form", "of", "cancer", "screening", "." ]

[ "umlsterm" ]

syndrome, fibromas, colonic polyps, literature, fibromas, mother, daughter, mother, colonic polyps, syndrome, syndrome, syndrome, fibromas, sequelae, acne, patient, colonic polyps, cancer, screening

DerHautarzt.60470304.eng.abstr_task2

Sentence: The syndrome of perifollicular fibromas and colonic polyps was delineated 20 years ago by Hornstein and Knickenberg ; it probably occurs more frequently than suggested by the literature . Multiple perifollicular fibromas were found in a mother and daughter . The mother also had colonic polyps . This dermo-intestinal syndrome varies in its clinical manifestations , but it is probably an autosomal dominant trait . We believe that the Hornstein-Knickenberg syndrome and the Birt-Hogg-Dubé syndrome are identical . If perifollicular fibromas are observed and cannot be explained as postinflammatory sequelae of acne , the patient should be examined for colonic polyps as an appropriate form of cancer screening . Instructions: please extract entity words from the input sentence

[ "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O" ]

The syndrome of perifollicular fibromas and colonic polyps was delineated 20 years ago by Hornstein and Knickenberg ; it probably occurs more frequently than suggested by the literature . Multiple perifollicular fibromas were found in a mother and daughter . The mother also had colonic polyps . This dermo-intestinal syndrome varies in its clinical manifestations , but it is probably an autosomal dominant trait . We believe that the Hornstein-Knickenberg syndrome and the Birt-Hogg-Dubé syndrome are identical . If perifollicular fibromas are observed and cannot be explained as postinflammatory sequelae of acne , the patient should be examined for colonic polyps as an appropriate form of cancer screening .

[ "The", "syndrome", "of", "perifollicular", "fibromas", "and", "colonic", "polyps", "was", "delineated", "20", "years", "ago", "by", "Hornstein", "and", "Knickenberg", ";", "it", "probably", "occurs", "more", "frequently", "than", "suggested", "by", "the", "literature", ".", "Multiple", "perifollicular", "fibromas", "were", "found", "in", "a", "mother", "and", "daughter", ".", "The", "mother", "also", "had", "colonic", "polyps", ".", "This", "dermo", "-", "intestinal", "syndrome", "varies", "in", "its", "clinical", "manifestations", ",", "but", "it", "is", "probably", "an", "autosomal", "dominant", "trait", ".", "We", "believe", "that", "the", "Hornstein", "-", "Knickenberg", "syndrome", "and", "the", "Birt", "-", "Hogg", "-", "Dubé", "syndrome", "are", "identical", ".", "If", "perifollicular", "fibromas", "are", "observed", "and", "cannot", "be", "explained", "as", "postinflammatory", "sequelae", "of", "acne", ",", "the", "patient", "should", "be", "examined", "for", "colonic", "polyps", "as", "an", "appropriate", "form", "of", "cancer", "screening", "." ]

[ "umlsterm" ]

Mateo is a NOMBRE_SUJETO_ASISTENCIA, Sanchez Rivas is a NOMBRE_SUJETO_ASISTENCIA, 7806239 is a ID_SUJETO_ASISTENCIA, Almeria is a TERRITORIO, 04201 is a TERRITORIO, 21/08/2001 is a FECHAS, España is a PAIS, 16 años is a EDAD_SUJETO_ASISTENCIA, 01/04/2018 is a FECHAS, Ana Cristina Cis Spoturno is a NOMBRE_PERSONAL_SANITARIO, 04 04 52302 is a ID_TITULACION_PERSONAL_SANITARIO, adolescente is a ID_SUJETO_ASISTENCIA, 16 años is a EDAD_SUJETO_ASISTENCIA, jugador de baloncesto de competición is a ID_SUJETO_ASISTENCIA, 5 años is a EDAD_SUJETO_ASISTENCIA, Centro Andaluz de Medicina del Deporte ( CAMD ) is a INSTITUCION, Almería is a TERRITORIO, 9 años is a EDAD_SUJETO_ASISTENCIA, tío paterno is a FAMILIARES_SUJETO_ASISTENCIA, padres is a FAMILIARES_SUJETO_ASISTENCIA, Ana Cristina Cis Spoturno is a NOMBRE_PERSONAL_SANITARIO, Centro Médico Deportivo is a INSTITUCION, Federico Garcia Lorca 50 is a CALLE, 04006 is a TERRITORIO, Almeria is a TERRITORIO, España is a PAIS, cmedicodeportivo@gmail.com is a CORREO_ELECTRONICO

497_task0

Sentence: Datos del paciente. Nombre: Mateo. Apellidos: Sanchez Rivas. NHC: 7806239. Domicilio: Calle Sancho Martin, 34, 2 A. Localidad/ Provincia: Almeria. CP: 04201. Datos asistenciales. Fecha de nacimiento: 21/08/2001. País: España. Edad: 16 años Sexo: H. Fecha de Ingreso: 01/04/2018. Médico: Ana Cristina Cis Spoturno NºCol: 04 04 52302. Informe clínico del paciente: adolescente de 16 años, jugador de baloncesto de competición desde los 5 años, que acudió al Centro Andaluz de Medicina del Deporte (CAMD) de Almería, para realizar un examen médico solicitado por su Federación. En la anamnesis refiere episodios de palpitaciones, cortos y autolimitados, durante el reposo y el esfuerzo. En el ECG de reposo se detectó un intervalo entre ondas P y R (intervalo PR) muy corto con onda delta, compatible con preexcitación por lo que fue derivado para valoración cardiológica. Destacan entre sus antecedentes personales una evaluación previa a los 9 años, en un paciente asintomático, con un ECG normal y la referencia de un tío paterno, afectado con una arritmia recientemente ablacionado. Un nuevo ECG de reposo confirmó un ritmo sinusal preexcitado, compatible con vía anteroseptal derecha y se descartó cardiopatía estructural mediante ecocardiografía. En el holter de ritmo de 24 horas, mantuvo preexcitación permanente y sin arritmias. La prueba de esfuerzo en cinta, con protocolo de Bruce fue concluyente y libre de arritmias, manteniendo el WPW a frecuencias cardíacas máximas. Considerando los datos previos y su condición de deportista de competición, fue enviado para estudio electrofisiológico (EEF) y ablación de vía anómala. El procedimiento fue realizado con dos electrocatéteres: uno para diagnóstico con registro del His y otro para mapeo y ablación en región septal perihisiana. En ritmo sinusal se indujo taquicardia ortodrómica y se aplicó radiofrecuencia (RF) sobre la vía accesoria auriculo-ventricular (AV) de conducción bidireccional. Se interrumpe la taquicardia y la preexcitación, finalizando el procedimiento. Quedó con bloqueo de rama derecha (BRD), de probable origen traumático. No hay descripción de período refractario efectivo de la vía anómala. En el primer control posterior, el paciente refiere la misma clínica anterior a la ablación y su manejo para interrumpir las taquicardias. El ECG basal y el holter de 24 horas, mantienen el patrón sinusal con WPW, sin documentarse taquicardias. Se ha planteado a los padres realizar nueva consulta al especialista en electrofisiología para ofrecerle las mejores opciones de tratamiento en relación a la práctica deportiva. Remitido por: Dra. Ana Cristina Cis Spoturno Centro Médico Deportivo Federico Garcia Lorca 50 04006 Almeria. España Correo electrónico: cmedicodeportivo@gmail.com Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: TERRITORIO, ID_SUJETO_ASISTENCIA, FECHAS, FAMILIARES_SUJETO_ASISTENCIA, CALLE, CORREO_ELECTRONICO, PAIS, EDAD_SUJETO_ASISTENCIA, INSTITUCION, ID_TITULACION_PERSONAL_SANITARIO, NOMBRE_SUJETO_ASISTENCIA, NOMBRE_PERSONAL_SANITARIO

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-NOMBRE_SUJETO_ASISTENCIA", "O", "O", "O", "O", "B-NOMBRE_SUJETO_ASISTENCIA", "I-NOMBRE_SUJETO_ASISTENCIA", "O", "O", "O", "O", "B-ID_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-TERRITORIO", "O", "O", "O", "O", "B-TERRITORIO", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-FECHAS", "O", "O", "O", "O", "B-PAIS", "O", "O", "O", "O", "B-EDAD_SUJETO_ASISTENCIA", "I-EDAD_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "B-FECHAS", "O", "O", "O", "O", "O", "B-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "O", "O", "B-ID_TITULACION_PERSONAL_SANITARIO", "I-ID_TITULACION_PERSONAL_SANITARIO", "I-ID_TITULACION_PERSONAL_SANITARIO", "O", "O", "O", "O", "O", "O", "O", "B-ID_SUJETO_ASISTENCIA", "O", "B-EDAD_SUJETO_ASISTENCIA", "I-EDAD_SUJETO_ASISTENCIA", "O", "B-ID_SUJETO_ASISTENCIA", "I-ID_SUJETO_ASISTENCIA", "I-ID_SUJETO_ASISTENCIA", "I-ID_SUJETO_ASISTENCIA", "I-ID_SUJETO_ASISTENCIA", "O", "O", "B-EDAD_SUJETO_ASISTENCIA", "I-EDAD_SUJETO_ASISTENCIA", "O", "O", "O", "O", "B-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "O", "B-TERRITORIO", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-EDAD_SUJETO_ASISTENCIA", "I-EDAD_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-FAMILIARES_SUJETO_ASISTENCIA", "I-FAMILIARES_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-FAMILIARES_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "B-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "B-CALLE", "I-CALLE", "I-CALLE", "I-CALLE", "B-TERRITORIO", "B-TERRITORIO", "O", "B-PAIS", "O", "O", "O", "B-CORREO_ELECTRONICO", "O" ]

Datos del paciente. Nombre: Mateo. Apellidos: Sanchez Rivas. NHC: 7806239. Domicilio: Calle Sancho Martin, 34, 2 A. Localidad/ Provincia: Almeria. CP: 04201. Datos asistenciales. Fecha de nacimiento: 21/08/2001. País: España. Edad: 16 años Sexo: H. Fecha de Ingreso: 01/04/2018. Médico: Ana Cristina Cis Spoturno NºCol: 04 04 52302. Informe clínico del paciente: adolescente de 16 años, jugador de baloncesto de competición desde los 5 años, que acudió al Centro Andaluz de Medicina del Deporte (CAMD) de Almería, para realizar un examen médico solicitado por su Federación. En la anamnesis refiere episodios de palpitaciones, cortos y autolimitados, durante el reposo y el esfuerzo. En el ECG de reposo se detectó un intervalo entre ondas P y R (intervalo PR) muy corto con onda delta, compatible con preexcitación por lo que fue derivado para valoración cardiológica. Destacan entre sus antecedentes personales una evaluación previa a los 9 años, en un paciente asintomático, con un ECG normal y la referencia de un tío paterno, afectado con una arritmia recientemente ablacionado. Un nuevo ECG de reposo confirmó un ritmo sinusal preexcitado, compatible con vía anteroseptal derecha y se descartó cardiopatía estructural mediante ecocardiografía. En el holter de ritmo de 24 horas, mantuvo preexcitación permanente y sin arritmias. La prueba de esfuerzo en cinta, con protocolo de Bruce fue concluyente y libre de arritmias, manteniendo el WPW a frecuencias cardíacas máximas. Considerando los datos previos y su condición de deportista de competición, fue enviado para estudio electrofisiológico (EEF) y ablación de vía anómala. El procedimiento fue realizado con dos electrocatéteres: uno para diagnóstico con registro del His y otro para mapeo y ablación en región septal perihisiana. En ritmo sinusal se indujo taquicardia ortodrómica y se aplicó radiofrecuencia (RF) sobre la vía accesoria auriculo-ventricular (AV) de conducción bidireccional. Se interrumpe la taquicardia y la preexcitación, finalizando el procedimiento. Quedó con bloqueo de rama derecha (BRD), de probable origen traumático. No hay descripción de período refractario efectivo de la vía anómala. En el primer control posterior, el paciente refiere la misma clínica anterior a la ablación y su manejo para interrumpir las taquicardias. El ECG basal y el holter de 24 horas, mantienen el patrón sinusal con WPW, sin documentarse taquicardias. Se ha planteado a los padres realizar nueva consulta al especialista en electrofisiología para ofrecerle las mejores opciones de tratamiento en relación a la práctica deportiva. Remitido por: Dra. Ana Cristina Cis Spoturno Centro Médico Deportivo Federico Garcia Lorca 50 04006 Almeria. España Correo electrónico: cmedicodeportivo@gmail.com

[ "Datos", "del", "paciente", ".", "\n", "Nombre", ":", " ", "Mateo", ".", "\n", "Apellidos", ":", "Sanchez", "Rivas", ".", "\n", "NHC", ":", "7806239", ".", "\n", "Domicilio", ":", "Calle", "Sancho", "Martin", ",", "34", ",", "2", "A.", "\n", "Localidad/", "Provincia", ":", "Almeria", ".", "\n", "CP", ":", "04201", ".", "\n", "Datos", "asistenciales", ".", "\n", "Fecha", "de", "nacimiento", ":", "21/08/2001", ".", "\n", "País", ":", "España", ".", "\n", "Edad", ":", "16", "años", "Sexo", ":", "H.", "\n", "Fecha", "de", "Ingreso", ":", "01/04/2018", ".", "\n", "Médico", ":", " ", "Ana", "Cristina", "Cis", "Spoturno", "NºCol", ":", "04", "04", "52302", ".", "\n", "Informe", "clínico", "del", "paciente", ":", "adolescente", "de", "16", "años", ",", "jugador", "de", "baloncesto", "de", "competición", "desde", "los", "5", "años", ",", "que", "acudió", "al", "Centro", "Andaluz", "de", "Medicina", "del", "Deporte", "(", "CAMD", ")", "de", "Almería", ",", "para", "realizar", "un", "examen", "médico", "solicitado", "por", "su", "Federación", ".", "En", "la", "anamnesis", "refiere", "episodios", "de", "palpitaciones", ",", "cortos", "y", "autolimitados", ",", "durante", "el", "reposo", "y", "el", "esfuerzo", ".", "En", "el", "ECG", "de", "reposo", "se", "detectó", "un", "intervalo", "entre", "ondas", "P", "y", "R", "(", "intervalo", "PR", ")", "muy", "corto", "con", "onda", "delta", ",", "compatible", "con", "preexcitación", "por", "lo", "que", "fue", "derivado", "para", "valoración", "cardiológica", ".", "\n", "Destacan", "entre", "sus", "antecedentes", "personales", "una", "evaluación", "previa", "a", "los", "9", "años", ",", "en", "un", "paciente", "asintomático", ",", "con", "un", "ECG", "normal", "y", "la", "referencia", "de", "un", "tío", "paterno", ",", "afectado", "con", "una", "arritmia", "recientemente", "ablacionado", ".", "\n", "Un", "nuevo", "ECG", "de", "reposo", "confirmó", "un", "ritmo", "sinusal", "preexcitado", ",", "compatible", "con", "vía", "anteroseptal", "derecha", "y", "se", "descartó", "cardiopatía", "estructural", "mediante", "ecocardiografía", ".", "En", "el", "holter", "de", "ritmo", "de", "24", "horas", ",", "mantuvo", "preexcitación", "permanente", "y", "sin", "arritmias", ".", "La", "prueba", "de", "esfuerzo", "en", "cinta", ",", "con", "protocolo", "de", "Bruce", "fue", "concluyente", "y", "libre", "de", "arritmias", ",", "manteniendo", "el", "WPW", "a", "frecuencias", "cardíacas", "máximas", ".", "\n", "Considerando", "los", "datos", "previos", "y", "su", "condición", "de", "deportista", "de", "competición", ",", "fue", "enviado", "para", "estudio", "electrofisiológico", "(", "EEF", ")", "y", "ablación", "de", "vía", "anómala", ".", "\n", "El", "procedimiento", "fue", "realizado", "con", "dos", "electrocatéteres", ":", "uno", "para", "diagnóstico", "con", "registro", "del", "His", "y", "otro", "para", "mapeo", "y", "ablación", "en", "región", "septal", "perihisiana", ".", "En", "ritmo", "sinusal", "se", "indujo", "taquicardia", "ortodrómica", "y", "se", "aplicó", "radiofrecuencia", "(", "RF", ")", "sobre", "la", "vía", "accesoria", "auriculo", "-", "ventricular", "(", "AV", ")", "de", "conducción", "bidireccional", ".", "Se", "interrumpe", "la", "taquicardia", "y", "la", "preexcitación", ",", "finalizando", "el", "procedimiento", ".", "Quedó", "con", "bloqueo", "de", "rama", "derecha", "(", "BRD", ")", ",", "de", "probable", "origen", "traumático", ".", "No", "hay", "descripción", "de", "período", "refractario", "efectivo", "de", "la", "vía", "anómala", ".", "\n", "En", "el", "primer", "control", "posterior", ",", "el", "paciente", "refiere", "la", "misma", "clínica", "anterior", "a", "la", "ablación", "y", "su", "manejo", "para", "interrumpir", "las", "taquicardias", ".", "El", "ECG", "basal", "y", "el", "holter", "de", "24", "horas", ",", "mantienen", "el", "patrón", "sinusal", "con", "WPW", ",", "sin", "documentarse", "taquicardias", ".", "\n", "Se", "ha", "planteado", "a", "los", "padres", "realizar", "nueva", "consulta", "al", "especialista", "en", "electrofisiología", "para", "ofrecerle", "las", "mejores", "opciones", "de", "tratamiento", "en", "relación", "a", "la", "práctica", "deportiva", ".", "\n", "Remitido", "por", ":", "Dra", ".", "Ana", "Cristina", "Cis", "Spoturno", "Centro", "Médico", "Deportivo", "Federico", "Garcia", "Lorca", "50", "04006", "Almeria", ".", "España", "Correo", "electrónico", ":", "cmedicodeportivo@gmail.com", "\n" ]

[ "INSTITUCION", "ID_SUJETO_ASISTENCIA", "CALLE", "CORREO_ELECTRONICO", "NOMBRE_PERSONAL_SANITARIO", "NOMBRE_SUJETO_ASISTENCIA", "FAMILIARES_SUJETO_ASISTENCIA", "ID_TITULACION_PERSONAL_SANITARIO", "FECHAS", "TERRITORIO", "EDAD_SUJETO_ASISTENCIA", "PAIS", "SEXO_SUJETO_ASISTENCIA" ]

Mateo is a NOMBRE_SUJETO_ASISTENCIA, Sanchez Rivas is a NOMBRE_SUJETO_ASISTENCIA, 7806239 is a ID_SUJETO_ASISTENCIA, Almeria is a TERRITORIO, 04201 is a TERRITORIO, 21/08/2001 is a FECHAS, España is a PAIS, 16 años is a EDAD_SUJETO_ASISTENCIA, 01/04/2018 is a FECHAS, Ana Cristina Cis Spoturno is a NOMBRE_PERSONAL_SANITARIO, 04 04 52302 is a ID_TITULACION_PERSONAL_SANITARIO, adolescente is a ID_SUJETO_ASISTENCIA, 16 años is a EDAD_SUJETO_ASISTENCIA, jugador de baloncesto de competición is a ID_SUJETO_ASISTENCIA, 5 años is a EDAD_SUJETO_ASISTENCIA, Centro Andaluz de Medicina del Deporte ( CAMD ) is a INSTITUCION, Almería is a TERRITORIO, 9 años is a EDAD_SUJETO_ASISTENCIA, tío paterno is a FAMILIARES_SUJETO_ASISTENCIA, padres is a FAMILIARES_SUJETO_ASISTENCIA, Ana Cristina Cis Spoturno is a NOMBRE_PERSONAL_SANITARIO, Centro Médico Deportivo is a INSTITUCION, Federico Garcia Lorca 50 is a CALLE, 04006 is a TERRITORIO, Almeria is a TERRITORIO, España is a PAIS, cmedicodeportivo@gmail.com is a CORREO_ELECTRONICO

497_task1

Sentence: Datos del paciente. Nombre: Mateo. Apellidos: Sanchez Rivas. NHC: 7806239. Domicilio: Calle Sancho Martin, 34, 2 A. Localidad/ Provincia: Almeria. CP: 04201. Datos asistenciales. Fecha de nacimiento: 21/08/2001. País: España. Edad: 16 años Sexo: H. Fecha de Ingreso: 01/04/2018. Médico: Ana Cristina Cis Spoturno NºCol: 04 04 52302. Informe clínico del paciente: adolescente de 16 años, jugador de baloncesto de competición desde los 5 años, que acudió al Centro Andaluz de Medicina del Deporte (CAMD) de Almería, para realizar un examen médico solicitado por su Federación. En la anamnesis refiere episodios de palpitaciones, cortos y autolimitados, durante el reposo y el esfuerzo. En el ECG de reposo se detectó un intervalo entre ondas P y R (intervalo PR) muy corto con onda delta, compatible con preexcitación por lo que fue derivado para valoración cardiológica. Destacan entre sus antecedentes personales una evaluación previa a los 9 años, en un paciente asintomático, con un ECG normal y la referencia de un tío paterno, afectado con una arritmia recientemente ablacionado. Un nuevo ECG de reposo confirmó un ritmo sinusal preexcitado, compatible con vía anteroseptal derecha y se descartó cardiopatía estructural mediante ecocardiografía. En el holter de ritmo de 24 horas, mantuvo preexcitación permanente y sin arritmias. La prueba de esfuerzo en cinta, con protocolo de Bruce fue concluyente y libre de arritmias, manteniendo el WPW a frecuencias cardíacas máximas. Considerando los datos previos y su condición de deportista de competición, fue enviado para estudio electrofisiológico (EEF) y ablación de vía anómala. El procedimiento fue realizado con dos electrocatéteres: uno para diagnóstico con registro del His y otro para mapeo y ablación en región septal perihisiana. En ritmo sinusal se indujo taquicardia ortodrómica y se aplicó radiofrecuencia (RF) sobre la vía accesoria auriculo-ventricular (AV) de conducción bidireccional. Se interrumpe la taquicardia y la preexcitación, finalizando el procedimiento. Quedó con bloqueo de rama derecha (BRD), de probable origen traumático. No hay descripción de período refractario efectivo de la vía anómala. En el primer control posterior, el paciente refiere la misma clínica anterior a la ablación y su manejo para interrumpir las taquicardias. El ECG basal y el holter de 24 horas, mantienen el patrón sinusal con WPW, sin documentarse taquicardias. Se ha planteado a los padres realizar nueva consulta al especialista en electrofisiología para ofrecerle las mejores opciones de tratamiento en relación a la práctica deportiva. Remitido por: Dra. Ana Cristina Cis Spoturno Centro Médico Deportivo Federico Garcia Lorca 50 04006 Almeria. España Correo electrónico: cmedicodeportivo@gmail.com Instructions: please typing these entity words according to sentence: Mateo, Sanchez Rivas, 7806239, Almeria, 04201, 21/08/2001, España, 16 años, 01/04/2018, Ana Cristina Cis Spoturno, 04 04 52302, adolescente, 16 años, jugador de baloncesto de competición, 5 años, Centro Andaluz de Medicina del Deporte ( CAMD ), Almería, 9 años, tío paterno, padres, Ana Cristina Cis Spoturno, Centro Médico Deportivo, Federico Garcia Lorca 50, 04006, Almeria, España, cmedicodeportivo@gmail.com Options: TERRITORIO, ID_SUJETO_ASISTENCIA, FECHAS, FAMILIARES_SUJETO_ASISTENCIA, CALLE, CORREO_ELECTRONICO, PAIS, EDAD_SUJETO_ASISTENCIA, INSTITUCION, ID_TITULACION_PERSONAL_SANITARIO, NOMBRE_SUJETO_ASISTENCIA, NOMBRE_PERSONAL_SANITARIO

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-NOMBRE_SUJETO_ASISTENCIA", "O", "O", "O", "O", "B-NOMBRE_SUJETO_ASISTENCIA", "I-NOMBRE_SUJETO_ASISTENCIA", "O", "O", "O", "O", "B-ID_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-TERRITORIO", "O", "O", "O", "O", "B-TERRITORIO", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-FECHAS", "O", "O", "O", "O", "B-PAIS", "O", "O", "O", "O", "B-EDAD_SUJETO_ASISTENCIA", "I-EDAD_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "B-FECHAS", "O", "O", "O", "O", "O", "B-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "O", "O", "B-ID_TITULACION_PERSONAL_SANITARIO", "I-ID_TITULACION_PERSONAL_SANITARIO", "I-ID_TITULACION_PERSONAL_SANITARIO", "O", "O", "O", "O", "O", "O", "O", "B-ID_SUJETO_ASISTENCIA", "O", "B-EDAD_SUJETO_ASISTENCIA", "I-EDAD_SUJETO_ASISTENCIA", "O", "B-ID_SUJETO_ASISTENCIA", "I-ID_SUJETO_ASISTENCIA", "I-ID_SUJETO_ASISTENCIA", "I-ID_SUJETO_ASISTENCIA", "I-ID_SUJETO_ASISTENCIA", "O", "O", "B-EDAD_SUJETO_ASISTENCIA", "I-EDAD_SUJETO_ASISTENCIA", "O", "O", "O", "O", "B-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "O", "B-TERRITORIO", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-EDAD_SUJETO_ASISTENCIA", "I-EDAD_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-FAMILIARES_SUJETO_ASISTENCIA", "I-FAMILIARES_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-FAMILIARES_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "B-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "B-CALLE", "I-CALLE", "I-CALLE", "I-CALLE", "B-TERRITORIO", "B-TERRITORIO", "O", "B-PAIS", "O", "O", "O", "B-CORREO_ELECTRONICO", "O" ]

Datos del paciente. Nombre: Mateo. Apellidos: Sanchez Rivas. NHC: 7806239. Domicilio: Calle Sancho Martin, 34, 2 A. Localidad/ Provincia: Almeria. CP: 04201. Datos asistenciales. Fecha de nacimiento: 21/08/2001. País: España. Edad: 16 años Sexo: H. Fecha de Ingreso: 01/04/2018. Médico: Ana Cristina Cis Spoturno NºCol: 04 04 52302. Informe clínico del paciente: adolescente de 16 años, jugador de baloncesto de competición desde los 5 años, que acudió al Centro Andaluz de Medicina del Deporte (CAMD) de Almería, para realizar un examen médico solicitado por su Federación. En la anamnesis refiere episodios de palpitaciones, cortos y autolimitados, durante el reposo y el esfuerzo. En el ECG de reposo se detectó un intervalo entre ondas P y R (intervalo PR) muy corto con onda delta, compatible con preexcitación por lo que fue derivado para valoración cardiológica. Destacan entre sus antecedentes personales una evaluación previa a los 9 años, en un paciente asintomático, con un ECG normal y la referencia de un tío paterno, afectado con una arritmia recientemente ablacionado. Un nuevo ECG de reposo confirmó un ritmo sinusal preexcitado, compatible con vía anteroseptal derecha y se descartó cardiopatía estructural mediante ecocardiografía. En el holter de ritmo de 24 horas, mantuvo preexcitación permanente y sin arritmias. La prueba de esfuerzo en cinta, con protocolo de Bruce fue concluyente y libre de arritmias, manteniendo el WPW a frecuencias cardíacas máximas. Considerando los datos previos y su condición de deportista de competición, fue enviado para estudio electrofisiológico (EEF) y ablación de vía anómala. El procedimiento fue realizado con dos electrocatéteres: uno para diagnóstico con registro del His y otro para mapeo y ablación en región septal perihisiana. En ritmo sinusal se indujo taquicardia ortodrómica y se aplicó radiofrecuencia (RF) sobre la vía accesoria auriculo-ventricular (AV) de conducción bidireccional. Se interrumpe la taquicardia y la preexcitación, finalizando el procedimiento. Quedó con bloqueo de rama derecha (BRD), de probable origen traumático. No hay descripción de período refractario efectivo de la vía anómala. En el primer control posterior, el paciente refiere la misma clínica anterior a la ablación y su manejo para interrumpir las taquicardias. El ECG basal y el holter de 24 horas, mantienen el patrón sinusal con WPW, sin documentarse taquicardias. Se ha planteado a los padres realizar nueva consulta al especialista en electrofisiología para ofrecerle las mejores opciones de tratamiento en relación a la práctica deportiva. Remitido por: Dra. Ana Cristina Cis Spoturno Centro Médico Deportivo Federico Garcia Lorca 50 04006 Almeria. España Correo electrónico: cmedicodeportivo@gmail.com

[ "Datos", "del", "paciente", ".", "\n", "Nombre", ":", " ", "Mateo", ".", "\n", "Apellidos", ":", "Sanchez", "Rivas", ".", "\n", "NHC", ":", "7806239", ".", "\n", "Domicilio", ":", "Calle", "Sancho", "Martin", ",", "34", ",", "2", "A.", "\n", "Localidad/", "Provincia", ":", "Almeria", ".", "\n", "CP", ":", "04201", ".", "\n", "Datos", "asistenciales", ".", "\n", "Fecha", "de", "nacimiento", ":", "21/08/2001", ".", "\n", "País", ":", "España", ".", "\n", "Edad", ":", "16", "años", "Sexo", ":", "H.", "\n", "Fecha", "de", "Ingreso", ":", "01/04/2018", ".", "\n", "Médico", ":", " ", "Ana", "Cristina", "Cis", "Spoturno", "NºCol", ":", "04", "04", "52302", ".", "\n", "Informe", "clínico", "del", "paciente", ":", "adolescente", "de", "16", "años", ",", "jugador", "de", "baloncesto", "de", "competición", "desde", "los", "5", "años", ",", "que", "acudió", "al", "Centro", "Andaluz", "de", "Medicina", "del", "Deporte", "(", "CAMD", ")", "de", "Almería", ",", "para", "realizar", "un", "examen", "médico", "solicitado", "por", "su", "Federación", ".", "En", "la", "anamnesis", "refiere", "episodios", "de", "palpitaciones", ",", "cortos", "y", "autolimitados", ",", "durante", "el", "reposo", "y", "el", "esfuerzo", ".", "En", "el", "ECG", "de", "reposo", "se", "detectó", "un", "intervalo", "entre", "ondas", "P", "y", "R", "(", "intervalo", "PR", ")", "muy", "corto", "con", "onda", "delta", ",", "compatible", "con", "preexcitación", "por", "lo", "que", "fue", "derivado", "para", "valoración", "cardiológica", ".", "\n", "Destacan", "entre", "sus", "antecedentes", "personales", "una", "evaluación", "previa", "a", "los", "9", "años", ",", "en", "un", "paciente", "asintomático", ",", "con", "un", "ECG", "normal", "y", "la", "referencia", "de", "un", "tío", "paterno", ",", "afectado", "con", "una", "arritmia", "recientemente", "ablacionado", ".", "\n", "Un", "nuevo", "ECG", "de", "reposo", "confirmó", "un", "ritmo", "sinusal", "preexcitado", ",", "compatible", "con", "vía", "anteroseptal", "derecha", "y", "se", "descartó", "cardiopatía", "estructural", "mediante", "ecocardiografía", ".", "En", "el", "holter", "de", "ritmo", "de", "24", "horas", ",", "mantuvo", "preexcitación", "permanente", "y", "sin", "arritmias", ".", "La", "prueba", "de", "esfuerzo", "en", "cinta", ",", "con", "protocolo", "de", "Bruce", "fue", "concluyente", "y", "libre", "de", "arritmias", ",", "manteniendo", "el", "WPW", "a", "frecuencias", "cardíacas", "máximas", ".", "\n", "Considerando", "los", "datos", "previos", "y", "su", "condición", "de", "deportista", "de", "competición", ",", "fue", "enviado", "para", "estudio", "electrofisiológico", "(", "EEF", ")", "y", "ablación", "de", "vía", "anómala", ".", "\n", "El", "procedimiento", "fue", "realizado", "con", "dos", "electrocatéteres", ":", "uno", "para", "diagnóstico", "con", "registro", "del", "His", "y", "otro", "para", "mapeo", "y", "ablación", "en", "región", "septal", "perihisiana", ".", "En", "ritmo", "sinusal", "se", "indujo", "taquicardia", "ortodrómica", "y", "se", "aplicó", "radiofrecuencia", "(", "RF", ")", "sobre", "la", "vía", "accesoria", "auriculo", "-", "ventricular", "(", "AV", ")", "de", "conducción", "bidireccional", ".", "Se", "interrumpe", "la", "taquicardia", "y", "la", "preexcitación", ",", "finalizando", "el", "procedimiento", ".", "Quedó", "con", "bloqueo", "de", "rama", "derecha", "(", "BRD", ")", ",", "de", "probable", "origen", "traumático", ".", "No", "hay", "descripción", "de", "período", "refractario", "efectivo", "de", "la", "vía", "anómala", ".", "\n", "En", "el", "primer", "control", "posterior", ",", "el", "paciente", "refiere", "la", "misma", "clínica", "anterior", "a", "la", "ablación", "y", "su", "manejo", "para", "interrumpir", "las", "taquicardias", ".", "El", "ECG", "basal", "y", "el", "holter", "de", "24", "horas", ",", "mantienen", "el", "patrón", "sinusal", "con", "WPW", ",", "sin", "documentarse", "taquicardias", ".", "\n", "Se", "ha", "planteado", "a", "los", "padres", "realizar", "nueva", "consulta", "al", "especialista", "en", "electrofisiología", "para", "ofrecerle", "las", "mejores", "opciones", "de", "tratamiento", "en", "relación", "a", "la", "práctica", "deportiva", ".", "\n", "Remitido", "por", ":", "Dra", ".", "Ana", "Cristina", "Cis", "Spoturno", "Centro", "Médico", "Deportivo", "Federico", "Garcia", "Lorca", "50", "04006", "Almeria", ".", "España", "Correo", "electrónico", ":", "cmedicodeportivo@gmail.com", "\n" ]

[ "INSTITUCION", "ID_SUJETO_ASISTENCIA", "CALLE", "CORREO_ELECTRONICO", "NOMBRE_PERSONAL_SANITARIO", "NOMBRE_SUJETO_ASISTENCIA", "FAMILIARES_SUJETO_ASISTENCIA", "ID_TITULACION_PERSONAL_SANITARIO", "FECHAS", "TERRITORIO", "EDAD_SUJETO_ASISTENCIA", "PAIS", "SEXO_SUJETO_ASISTENCIA" ]

Mateo, Sanchez Rivas, 7806239, Almeria, 04201, 21/08/2001, España, 16 años, 01/04/2018, Ana Cristina Cis Spoturno, 04 04 52302, adolescente, 16 años, jugador de baloncesto de competición, 5 años, Centro Andaluz de Medicina del Deporte ( CAMD ), Almería, 9 años, tío paterno, padres, Ana Cristina Cis Spoturno, Centro Médico Deportivo, Federico Garcia Lorca 50, 04006, Almeria, España, cmedicodeportivo@gmail.com

497_task2

Sentence: Datos del paciente. Nombre: Mateo. Apellidos: Sanchez Rivas. NHC: 7806239. Domicilio: Calle Sancho Martin, 34, 2 A. Localidad/ Provincia: Almeria. CP: 04201. Datos asistenciales. Fecha de nacimiento: 21/08/2001. País: España. Edad: 16 años Sexo: H. Fecha de Ingreso: 01/04/2018. Médico: Ana Cristina Cis Spoturno NºCol: 04 04 52302. Informe clínico del paciente: adolescente de 16 años, jugador de baloncesto de competición desde los 5 años, que acudió al Centro Andaluz de Medicina del Deporte (CAMD) de Almería, para realizar un examen médico solicitado por su Federación. En la anamnesis refiere episodios de palpitaciones, cortos y autolimitados, durante el reposo y el esfuerzo. En el ECG de reposo se detectó un intervalo entre ondas P y R (intervalo PR) muy corto con onda delta, compatible con preexcitación por lo que fue derivado para valoración cardiológica. Destacan entre sus antecedentes personales una evaluación previa a los 9 años, en un paciente asintomático, con un ECG normal y la referencia de un tío paterno, afectado con una arritmia recientemente ablacionado. Un nuevo ECG de reposo confirmó un ritmo sinusal preexcitado, compatible con vía anteroseptal derecha y se descartó cardiopatía estructural mediante ecocardiografía. En el holter de ritmo de 24 horas, mantuvo preexcitación permanente y sin arritmias. La prueba de esfuerzo en cinta, con protocolo de Bruce fue concluyente y libre de arritmias, manteniendo el WPW a frecuencias cardíacas máximas. Considerando los datos previos y su condición de deportista de competición, fue enviado para estudio electrofisiológico (EEF) y ablación de vía anómala. El procedimiento fue realizado con dos electrocatéteres: uno para diagnóstico con registro del His y otro para mapeo y ablación en región septal perihisiana. En ritmo sinusal se indujo taquicardia ortodrómica y se aplicó radiofrecuencia (RF) sobre la vía accesoria auriculo-ventricular (AV) de conducción bidireccional. Se interrumpe la taquicardia y la preexcitación, finalizando el procedimiento. Quedó con bloqueo de rama derecha (BRD), de probable origen traumático. No hay descripción de período refractario efectivo de la vía anómala. En el primer control posterior, el paciente refiere la misma clínica anterior a la ablación y su manejo para interrumpir las taquicardias. El ECG basal y el holter de 24 horas, mantienen el patrón sinusal con WPW, sin documentarse taquicardias. Se ha planteado a los padres realizar nueva consulta al especialista en electrofisiología para ofrecerle las mejores opciones de tratamiento en relación a la práctica deportiva. Remitido por: Dra. Ana Cristina Cis Spoturno Centro Médico Deportivo Federico Garcia Lorca 50 04006 Almeria. España Correo electrónico: cmedicodeportivo@gmail.com Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-NOMBRE_SUJETO_ASISTENCIA", "O", "O", "O", "O", "B-NOMBRE_SUJETO_ASISTENCIA", "I-NOMBRE_SUJETO_ASISTENCIA", "O", "O", "O", "O", "B-ID_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-TERRITORIO", "O", "O", "O", "O", "B-TERRITORIO", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-FECHAS", "O", "O", "O", "O", "B-PAIS", "O", "O", "O", "O", "B-EDAD_SUJETO_ASISTENCIA", "I-EDAD_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "B-FECHAS", "O", "O", "O", "O", "O", "B-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "O", "O", "B-ID_TITULACION_PERSONAL_SANITARIO", "I-ID_TITULACION_PERSONAL_SANITARIO", "I-ID_TITULACION_PERSONAL_SANITARIO", "O", "O", "O", "O", "O", "O", "O", "B-ID_SUJETO_ASISTENCIA", "O", "B-EDAD_SUJETO_ASISTENCIA", "I-EDAD_SUJETO_ASISTENCIA", "O", "B-ID_SUJETO_ASISTENCIA", "I-ID_SUJETO_ASISTENCIA", "I-ID_SUJETO_ASISTENCIA", "I-ID_SUJETO_ASISTENCIA", "I-ID_SUJETO_ASISTENCIA", "O", "O", "B-EDAD_SUJETO_ASISTENCIA", "I-EDAD_SUJETO_ASISTENCIA", "O", "O", "O", "O", "B-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "O", "B-TERRITORIO", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-EDAD_SUJETO_ASISTENCIA", "I-EDAD_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-FAMILIARES_SUJETO_ASISTENCIA", "I-FAMILIARES_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-FAMILIARES_SUJETO_ASISTENCIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "I-NOMBRE_PERSONAL_SANITARIO", "B-INSTITUCION", "I-INSTITUCION", "I-INSTITUCION", "B-CALLE", "I-CALLE", "I-CALLE", "I-CALLE", "B-TERRITORIO", "B-TERRITORIO", "O", "B-PAIS", "O", "O", "O", "B-CORREO_ELECTRONICO", "O" ]

Datos del paciente. Nombre: Mateo. Apellidos: Sanchez Rivas. NHC: 7806239. Domicilio: Calle Sancho Martin, 34, 2 A. Localidad/ Provincia: Almeria. CP: 04201. Datos asistenciales. Fecha de nacimiento: 21/08/2001. País: España. Edad: 16 años Sexo: H. Fecha de Ingreso: 01/04/2018. Médico: Ana Cristina Cis Spoturno NºCol: 04 04 52302. Informe clínico del paciente: adolescente de 16 años, jugador de baloncesto de competición desde los 5 años, que acudió al Centro Andaluz de Medicina del Deporte (CAMD) de Almería, para realizar un examen médico solicitado por su Federación. En la anamnesis refiere episodios de palpitaciones, cortos y autolimitados, durante el reposo y el esfuerzo. En el ECG de reposo se detectó un intervalo entre ondas P y R (intervalo PR) muy corto con onda delta, compatible con preexcitación por lo que fue derivado para valoración cardiológica. Destacan entre sus antecedentes personales una evaluación previa a los 9 años, en un paciente asintomático, con un ECG normal y la referencia de un tío paterno, afectado con una arritmia recientemente ablacionado. Un nuevo ECG de reposo confirmó un ritmo sinusal preexcitado, compatible con vía anteroseptal derecha y se descartó cardiopatía estructural mediante ecocardiografía. En el holter de ritmo de 24 horas, mantuvo preexcitación permanente y sin arritmias. La prueba de esfuerzo en cinta, con protocolo de Bruce fue concluyente y libre de arritmias, manteniendo el WPW a frecuencias cardíacas máximas. Considerando los datos previos y su condición de deportista de competición, fue enviado para estudio electrofisiológico (EEF) y ablación de vía anómala. El procedimiento fue realizado con dos electrocatéteres: uno para diagnóstico con registro del His y otro para mapeo y ablación en región septal perihisiana. En ritmo sinusal se indujo taquicardia ortodrómica y se aplicó radiofrecuencia (RF) sobre la vía accesoria auriculo-ventricular (AV) de conducción bidireccional. Se interrumpe la taquicardia y la preexcitación, finalizando el procedimiento. Quedó con bloqueo de rama derecha (BRD), de probable origen traumático. No hay descripción de período refractario efectivo de la vía anómala. En el primer control posterior, el paciente refiere la misma clínica anterior a la ablación y su manejo para interrumpir las taquicardias. El ECG basal y el holter de 24 horas, mantienen el patrón sinusal con WPW, sin documentarse taquicardias. Se ha planteado a los padres realizar nueva consulta al especialista en electrofisiología para ofrecerle las mejores opciones de tratamiento en relación a la práctica deportiva. Remitido por: Dra. Ana Cristina Cis Spoturno Centro Médico Deportivo Federico Garcia Lorca 50 04006 Almeria. España Correo electrónico: cmedicodeportivo@gmail.com

[ "Datos", "del", "paciente", ".", "\n", "Nombre", ":", " ", "Mateo", ".", "\n", "Apellidos", ":", "Sanchez", "Rivas", ".", "\n", "NHC", ":", "7806239", ".", "\n", "Domicilio", ":", "Calle", "Sancho", "Martin", ",", "34", ",", "2", "A.", "\n", "Localidad/", "Provincia", ":", "Almeria", ".", "\n", "CP", ":", "04201", ".", "\n", "Datos", "asistenciales", ".", "\n", "Fecha", "de", "nacimiento", ":", "21/08/2001", ".", "\n", "País", ":", "España", ".", "\n", "Edad", ":", "16", "años", "Sexo", ":", "H.", "\n", "Fecha", "de", "Ingreso", ":", "01/04/2018", ".", "\n", "Médico", ":", " ", "Ana", "Cristina", "Cis", "Spoturno", "NºCol", ":", "04", "04", "52302", ".", "\n", "Informe", "clínico", "del", "paciente", ":", "adolescente", "de", "16", "años", ",", "jugador", "de", "baloncesto", "de", "competición", "desde", "los", "5", "años", ",", "que", "acudió", "al", "Centro", "Andaluz", "de", "Medicina", "del", "Deporte", "(", "CAMD", ")", "de", "Almería", ",", "para", "realizar", "un", "examen", "médico", "solicitado", "por", "su", "Federación", ".", "En", "la", "anamnesis", "refiere", "episodios", "de", "palpitaciones", ",", "cortos", "y", "autolimitados", ",", "durante", "el", "reposo", "y", "el", "esfuerzo", ".", "En", "el", "ECG", "de", "reposo", "se", "detectó", "un", "intervalo", "entre", "ondas", "P", "y", "R", "(", "intervalo", "PR", ")", "muy", "corto", "con", "onda", "delta", ",", "compatible", "con", "preexcitación", "por", "lo", "que", "fue", "derivado", "para", "valoración", "cardiológica", ".", "\n", "Destacan", "entre", "sus", "antecedentes", "personales", "una", "evaluación", "previa", "a", "los", "9", "años", ",", "en", "un", "paciente", "asintomático", ",", "con", "un", "ECG", "normal", "y", "la", "referencia", "de", "un", "tío", "paterno", ",", "afectado", "con", "una", "arritmia", "recientemente", "ablacionado", ".", "\n", "Un", "nuevo", "ECG", "de", "reposo", "confirmó", "un", "ritmo", "sinusal", "preexcitado", ",", "compatible", "con", "vía", "anteroseptal", "derecha", "y", "se", "descartó", "cardiopatía", "estructural", "mediante", "ecocardiografía", ".", "En", "el", "holter", "de", "ritmo", "de", "24", "horas", ",", "mantuvo", "preexcitación", "permanente", "y", "sin", "arritmias", ".", "La", "prueba", "de", "esfuerzo", "en", "cinta", ",", "con", "protocolo", "de", "Bruce", "fue", "concluyente", "y", "libre", "de", "arritmias", ",", "manteniendo", "el", "WPW", "a", "frecuencias", "cardíacas", "máximas", ".", "\n", "Considerando", "los", "datos", "previos", "y", "su", "condición", "de", "deportista", "de", "competición", ",", "fue", "enviado", "para", "estudio", "electrofisiológico", "(", "EEF", ")", "y", "ablación", "de", "vía", "anómala", ".", "\n", "El", "procedimiento", "fue", "realizado", "con", "dos", "electrocatéteres", ":", "uno", "para", "diagnóstico", "con", "registro", "del", "His", "y", "otro", "para", "mapeo", "y", "ablación", "en", "región", "septal", "perihisiana", ".", "En", "ritmo", "sinusal", "se", "indujo", "taquicardia", "ortodrómica", "y", "se", "aplicó", "radiofrecuencia", "(", "RF", ")", "sobre", "la", "vía", "accesoria", "auriculo", "-", "ventricular", "(", "AV", ")", "de", "conducción", "bidireccional", ".", "Se", "interrumpe", "la", "taquicardia", "y", "la", "preexcitación", ",", "finalizando", "el", "procedimiento", ".", "Quedó", "con", "bloqueo", "de", "rama", "derecha", "(", "BRD", ")", ",", "de", "probable", "origen", "traumático", ".", "No", "hay", "descripción", "de", "período", "refractario", "efectivo", "de", "la", "vía", "anómala", ".", "\n", "En", "el", "primer", "control", "posterior", ",", "el", "paciente", "refiere", "la", "misma", "clínica", "anterior", "a", "la", "ablación", "y", "su", "manejo", "para", "interrumpir", "las", "taquicardias", ".", "El", "ECG", "basal", "y", "el", "holter", "de", "24", "horas", ",", "mantienen", "el", "patrón", "sinusal", "con", "WPW", ",", "sin", "documentarse", "taquicardias", ".", "\n", "Se", "ha", "planteado", "a", "los", "padres", "realizar", "nueva", "consulta", "al", "especialista", "en", "electrofisiología", "para", "ofrecerle", "las", "mejores", "opciones", "de", "tratamiento", "en", "relación", "a", "la", "práctica", "deportiva", ".", "\n", "Remitido", "por", ":", "Dra", ".", "Ana", "Cristina", "Cis", "Spoturno", "Centro", "Médico", "Deportivo", "Federico", "Garcia", "Lorca", "50", "04006", "Almeria", ".", "España", "Correo", "electrónico", ":", "cmedicodeportivo@gmail.com", "\n" ]

[ "INSTITUCION", "ID_SUJETO_ASISTENCIA", "CALLE", "CORREO_ELECTRONICO", "NOMBRE_PERSONAL_SANITARIO", "NOMBRE_SUJETO_ASISTENCIA", "FAMILIARES_SUJETO_ASISTENCIA", "ID_TITULACION_PERSONAL_SANITARIO", "FECHAS", "TERRITORIO", "EDAD_SUJETO_ASISTENCIA", "PAIS", "SEXO_SUJETO_ASISTENCIA" ]

balloon angioplasty is an umlsterm, PTA is an umlsterm, treatment is an umlsterm, disease is an umlsterm

DerRadiologe.90390144.eng.abstr_task0

Sentence: Purpose : To evaluate whether primary stenting is superior to balloon angioplasty ( PTA ) alone in the treatment of femoropopliteal obstructive disease . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O" ]

Purpose : To evaluate whether primary stenting is superior to balloon angioplasty ( PTA ) alone in the treatment of femoropopliteal obstructive disease .

[ "Purpose", ":", "To", "evaluate", "whether", "primary", "stenting", "is", "superior", "to", "balloon", "angioplasty", "(", "PTA", ")", "alone", "in", "the", "treatment", "of", "femoropopliteal", "obstructive", "disease", "." ]

[ "umlsterm" ]

balloon angioplasty is an umlsterm, PTA is an umlsterm, treatment is an umlsterm, disease is an umlsterm

DerRadiologe.90390144.eng.abstr_task1

Sentence: Purpose : To evaluate whether primary stenting is superior to balloon angioplasty ( PTA ) alone in the treatment of femoropopliteal obstructive disease . Instructions: please typing these entity words according to sentence: balloon angioplasty, PTA, treatment, disease Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O" ]

Purpose : To evaluate whether primary stenting is superior to balloon angioplasty ( PTA ) alone in the treatment of femoropopliteal obstructive disease .

[ "Purpose", ":", "To", "evaluate", "whether", "primary", "stenting", "is", "superior", "to", "balloon", "angioplasty", "(", "PTA", ")", "alone", "in", "the", "treatment", "of", "femoropopliteal", "obstructive", "disease", "." ]

[ "umlsterm" ]

balloon angioplasty, PTA, treatment, disease

DerRadiologe.90390144.eng.abstr_task2

Sentence: Purpose : To evaluate whether primary stenting is superior to balloon angioplasty ( PTA ) alone in the treatment of femoropopliteal obstructive disease . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O" ]

Purpose : To evaluate whether primary stenting is superior to balloon angioplasty ( PTA ) alone in the treatment of femoropopliteal obstructive disease .

[ "Purpose", ":", "To", "evaluate", "whether", "primary", "stenting", "is", "superior", "to", "balloon", "angioplasty", "(", "PTA", ")", "alone", "in", "the", "treatment", "of", "femoropopliteal", "obstructive", "disease", "." ]

[ "umlsterm" ]

gunshot wounds is an umlsterm, head is an umlsterm, neck is an umlsterm, injuries is an umlsterm, head is an umlsterm, neck is an umlsterm, therapeutic is an umlsterm, injuries is an umlsterm, treatment is an umlsterm, choice is an umlsterm, conventional surgery is an umlsterm, stress is an umlsterm, patient is an umlsterm

MundKieferGesichtschirurgie.90030102.eng.abstr_task0

Sentence: Internal gunshot wounds in the head and neck region are complicated . Two cases of such injuries in the head and neck region are introduced and therapeutic approaches are discussed . If there are no severe additional injuries , the treatment of choice is the endoscopic removal of the projectile . Alternatively , the projectile has to be taken out by conventional surgery , using the approach which induces the least stress for the patient . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]

Internal gunshot wounds in the head and neck region are complicated . Two cases of such injuries in the head and neck region are introduced and therapeutic approaches are discussed . If there are no severe additional injuries , the treatment of choice is the endoscopic removal of the projectile . Alternatively , the projectile has to be taken out by conventional surgery , using the approach which induces the least stress for the patient .

[ "Internal", "gunshot", "wounds", "in", "the", "head", "and", "neck", "region", "are", "complicated", ".", "Two", "cases", "of", "such", "injuries", "in", "the", "head", "and", "neck", "region", "are", "introduced", "and", "therapeutic", "approaches", "are", "discussed", ".", "If", "there", "are", "no", "severe", "additional", "injuries", ",", "the", "treatment", "of", "choice", "is", "the", "endoscopic", "removal", "of", "the", "projectile", ".", "Alternatively", ",", "the", "projectile", "has", "to", "be", "taken", "out", "by", "conventional", "surgery", ",", "using", "the", "approach", "which", "induces", "the", "least", "stress", "for", "the", "patient", "." ]

[ "umlsterm" ]

gunshot wounds is an umlsterm, head is an umlsterm, neck is an umlsterm, injuries is an umlsterm, head is an umlsterm, neck is an umlsterm, therapeutic is an umlsterm, injuries is an umlsterm, treatment is an umlsterm, choice is an umlsterm, conventional surgery is an umlsterm, stress is an umlsterm, patient is an umlsterm

MundKieferGesichtschirurgie.90030102.eng.abstr_task1

Sentence: Internal gunshot wounds in the head and neck region are complicated . Two cases of such injuries in the head and neck region are introduced and therapeutic approaches are discussed . If there are no severe additional injuries , the treatment of choice is the endoscopic removal of the projectile . Alternatively , the projectile has to be taken out by conventional surgery , using the approach which induces the least stress for the patient . Instructions: please typing these entity words according to sentence: gunshot wounds, head, neck, injuries, head, neck, therapeutic, injuries, treatment, choice, conventional surgery, stress, patient Options: umlsterm

[ "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]

Internal gunshot wounds in the head and neck region are complicated . Two cases of such injuries in the head and neck region are introduced and therapeutic approaches are discussed . If there are no severe additional injuries , the treatment of choice is the endoscopic removal of the projectile . Alternatively , the projectile has to be taken out by conventional surgery , using the approach which induces the least stress for the patient .

[ "Internal", "gunshot", "wounds", "in", "the", "head", "and", "neck", "region", "are", "complicated", ".", "Two", "cases", "of", "such", "injuries", "in", "the", "head", "and", "neck", "region", "are", "introduced", "and", "therapeutic", "approaches", "are", "discussed", ".", "If", "there", "are", "no", "severe", "additional", "injuries", ",", "the", "treatment", "of", "choice", "is", "the", "endoscopic", "removal", "of", "the", "projectile", ".", "Alternatively", ",", "the", "projectile", "has", "to", "be", "taken", "out", "by", "conventional", "surgery", ",", "using", "the", "approach", "which", "induces", "the", "least", "stress", "for", "the", "patient", "." ]

[ "umlsterm" ]

gunshot wounds, head, neck, injuries, head, neck, therapeutic, injuries, treatment, choice, conventional surgery, stress, patient

MundKieferGesichtschirurgie.90030102.eng.abstr_task2

Sentence: Internal gunshot wounds in the head and neck region are complicated . Two cases of such injuries in the head and neck region are introduced and therapeutic approaches are discussed . If there are no severe additional injuries , the treatment of choice is the endoscopic removal of the projectile . Alternatively , the projectile has to be taken out by conventional surgery , using the approach which induces the least stress for the patient . Instructions: please extract entity words from the input sentence

[ "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]

Internal gunshot wounds in the head and neck region are complicated . Two cases of such injuries in the head and neck region are introduced and therapeutic approaches are discussed . If there are no severe additional injuries , the treatment of choice is the endoscopic removal of the projectile . Alternatively , the projectile has to be taken out by conventional surgery , using the approach which induces the least stress for the patient .

[ "Internal", "gunshot", "wounds", "in", "the", "head", "and", "neck", "region", "are", "complicated", ".", "Two", "cases", "of", "such", "injuries", "in", "the", "head", "and", "neck", "region", "are", "introduced", "and", "therapeutic", "approaches", "are", "discussed", ".", "If", "there", "are", "no", "severe", "additional", "injuries", ",", "the", "treatment", "of", "choice", "is", "the", "endoscopic", "removal", "of", "the", "projectile", ".", "Alternatively", ",", "the", "projectile", "has", "to", "be", "taken", "out", "by", "conventional", "surgery", ",", "using", "the", "approach", "which", "induces", "the", "least", "stress", "for", "the", "patient", "." ]

[ "umlsterm" ]

tumor is a MORFOLOGIA_NEOPLASIA, tumoral is a MORFOLOGIA_NEOPLASIA, timoma tipo B1 is a MORFOLOGIA_NEOPLASIA, progresión pleural is a MORFOLOGIA_NEOPLASIA, lesiones pleurales is a MORFOLOGIA_NEOPLASIA, enfermedad a nivel pleural is a MORFOLOGIA_NEOPLASIA, enfermedad locorregional y pleural is a MORFOLOGIA_NEOPLASIA, timoma tipo B2 invasor is a MORFOLOGIA_NEOPLASIA, progresión a nivel pleuropulmonar is a MORFOLOGIA_NEOPLASIA, implantes intraabdominales is a MORFOLOGIA_NEOPLASIA, timoma is a MORFOLOGIA_NEOPLASIA, tumor is a MORFOLOGIA_NEOPLASIA

391_task0

Sentence: Anamnesis Mujer de 39 años, sin antecedentes de interés. En diciembre de 2012 inicia estudio en su país de origen por cuadro de disnea de un año de evolución asociado a dolor torácico. La TC objetiva un tumor de 92 x 74 mm que ocupa el mediastino anterior y que invade pericardio, porción ascendente del cayado aórtico y tronco de la arteria pulmonar. Se realiza resección tumoral parcial en enero de 2013, obteniendo el diagnóstico anatomopatológico de timoma tipo B1 con infiltración capsular. Posteriormente, la paciente es derivada a consultas de Oncología, donde se plantea quimioterapia complementaria según esquema Descripción epirrubicina-"platamina", del que recibe 4 ciclos (último en mayo 2013). Tras progresión locorregional en septiembre 2013 y tras haber comentado caso en comité de tumores torácicos, se decide tratamiento con quimio-radioterapia concomitante con cisplatino (21 sesiones de radioterapia). Posteriormente la paciente inicia seguimiento y se traslada a nuestro país. En agosto de 2014 presenta nueva progresión pleural y pararrenal izquierda, iniciando nueva línea de tratamiento según esquema Ifosfamida 1,5 mg/m2 durante 5 días, del que sólo pudo recibir un ciclo por neutropenia grado IV mantenida, requiriendo modificar esquema a TAXOL semanal (2 on y 1 off) y del que recibe 6 ciclos con estabilización de la enfermedad. Posteriormente se realiza radioterapia de consolidación sobre lesiones pleurales y pararrenal izquierda, finalizando el tratamiento en agosto 2015. En marzo de 2016 se evidencia en TC nueva recaída de la enfermedad a nivel pleural y se reinicia TAXOL semanal, recibiendo sólo 3 ciclos por presentar de nuevo toxicidad hematológica. Mantiene estabilidad de la enfermedad hasta enero de 2017, donde progresa de nuevo a nivel pleural y ganglionar. Ante el antecedente de toxicidad previa, se inicia tratamiento con pemetrexed 500 mg/m2 día 1 cada 21 días, recibiendo un total de 6 ciclos desde marzo a septiembre 2017 e iniciando de nuevo seguimiento (se decide stop de tratamiento por estabilidad de la enfermedad y toxicidad acumulada). En diciembre 2017 se evidencia progresión de la enfermedad locorregional y pleural comentándose caso en comité de tumores y decidiéndose resección parcial de la enfermedad, que se realiza en febrero 2018. La Anatomía Patológica fue de timoma tipo B2 invasor con alto índice proliferativo (Ki 67 de 40-50 %) y alta expresión de PDL1 (80 %). Tras la cirugía, la enfermedad se mantendría estable hasta septiembre de 2018, donde se objetiva nueva progresión a nivel pleuropulmonar, pararrenal y nuevos implantes intraabdominales. Se vuelve a comentar caso en sesión y ante hallazgos de Anatomía Patológica y toxicidad previa a quimioterapia, se solicita inmunoterapia con nivolumab como uso compasivo, iniciando ciclo 1 el 26 de septiembre de 2018. El día 5 de octubre consulta en el Servicio de Urgencias por cuadro de 3-4 días de evolución de astenia, debilidad muscular proximal, ptosis y diplopía. Exploración física » Consciente, orientada, afebril, eupneica en reposo. » NRL: funciones superiores conservadas. Pupilas "normocóricas" y normorreactivas, ptosis bilateral, oftalmoparesia para la aducción de ambos rectos internos en mirada lateral. » Balance motor: deltoides basal 4+/5 bilateral, tras 10 repeticiones fatiga y 4-/5 derecho y 3/5 izquierdo. Flexores de cuello basal 4/5, tras 5 repeticiones 3-/5. » Test del hielo en consulta positivo: mejoría notable de la oftalmoparesia y la ptosis. Pruebas complementarias » » Analítica con bioquímica, hemograma y coagulación rigurosamente normal. » » Se realiza TC de cráneo en el que no se objetivan hallazgos patológicos. » Se extrae analítica para estudio de perfil autoinmune (anticuerpos anti-AChR, anti-Musk y anti-músculo estriado). Diagnóstico Sospecha de miastenia gravis en paciente con timoma tras primer ciclo de nivolumab. Tratamiento » Piridostigmina 60 mg cada 8 horas. » Prednisona 60 mg cada 24 horas. Evolución Tras alta a domicilio con piridostigmina y corticoides, la paciente consulta de nuevo en Urgencias a los 5 días por el mismo cuadro, asociando, además, disnea y tos de 24-48 horas de evolución, sin fiebre. Se realiza angio-TC de tórax, la cual descarta progresión de la enfermedad, TEP, neumonía o neumonitis por toxicidad a inmunoterapia. Se traslada a sala de observación para iniciar tratamiento intravenoso con inmunoglobulinas y, ante la no mejoría del cuadro y la inestabilización de la paciente, termina ingresando en UCI. La paciente requiere intubación orotraqueal y tratamiento mediante plasmaféresis. Tras la primera semana, en la que no se había obtenido respuesta al tratamiento, se reciben los resultados de los anticuerpos solicitados: anti-AChR > 20 (0-0,45) y anti-Musk < 0,4 (0-0,4). En aquel momento se considera el diagnóstico de crisis miasténica Osserman grado 5 en relación a síndrome paraneoplásico del tumor primario, por lo que se presenta el caso en comité de tumores y se decide iniciar quimioterapia según esquema cisplatino, doxorrubicina y ciclofosfamida (CAP). Tras el primer ciclo, parece existir una ligera respuesta durante las primeras 48 horas. Sin embargo, y a pesar de un segundo ciclo de tratamiento, el cuadro continuaría progresando hasta finalmente producir la muerte de la paciente tras 38 días de ingreso en UCI. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: MORFOLOGIA_NEOPLASIA

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Anamnesis Mujer de 39 años, sin antecedentes de interés. En diciembre de 2012 inicia estudio en su país de origen por cuadro de disnea de un año de evolución asociado a dolor torácico. La TC objetiva un tumor de 92 x 74 mm que ocupa el mediastino anterior y que invade pericardio, porción ascendente del cayado aórtico y tronco de la arteria pulmonar. Se realiza resección tumoral parcial en enero de 2013, obteniendo el diagnóstico anatomopatológico de timoma tipo B1 con infiltración capsular. Posteriormente, la paciente es derivada a consultas de Oncología, donde se plantea quimioterapia complementaria según esquema Descripción epirrubicina-"platamina", del que recibe 4 ciclos (último en mayo 2013). Tras progresión locorregional en septiembre 2013 y tras haber comentado caso en comité de tumores torácicos, se decide tratamiento con quimio-radioterapia concomitante con cisplatino (21 sesiones de radioterapia). Posteriormente la paciente inicia seguimiento y se traslada a nuestro país. En agosto de 2014 presenta nueva progresión pleural y pararrenal izquierda, iniciando nueva línea de tratamiento según esquema Ifosfamida 1,5 mg/m2 durante 5 días, del que sólo pudo recibir un ciclo por neutropenia grado IV mantenida, requiriendo modificar esquema a TAXOL semanal (2 on y 1 off) y del que recibe 6 ciclos con estabilización de la enfermedad. Posteriormente se realiza radioterapia de consolidación sobre lesiones pleurales y pararrenal izquierda, finalizando el tratamiento en agosto 2015. En marzo de 2016 se evidencia en TC nueva recaída de la enfermedad a nivel pleural y se reinicia TAXOL semanal, recibiendo sólo 3 ciclos por presentar de nuevo toxicidad hematológica. Mantiene estabilidad de la enfermedad hasta enero de 2017, donde progresa de nuevo a nivel pleural y ganglionar. Ante el antecedente de toxicidad previa, se inicia tratamiento con pemetrexed 500 mg/m2 día 1 cada 21 días, recibiendo un total de 6 ciclos desde marzo a septiembre 2017 e iniciando de nuevo seguimiento (se decide stop de tratamiento por estabilidad de la enfermedad y toxicidad acumulada). En diciembre 2017 se evidencia progresión de la enfermedad locorregional y pleural comentándose caso en comité de tumores y decidiéndose resección parcial de la enfermedad, que se realiza en febrero 2018. La Anatomía Patológica fue de timoma tipo B2 invasor con alto índice proliferativo (Ki 67 de 40-50 %) y alta expresión de PDL1 (80 %). Tras la cirugía, la enfermedad se mantendría estable hasta septiembre de 2018, donde se objetiva nueva progresión a nivel pleuropulmonar, pararrenal y nuevos implantes intraabdominales. Se vuelve a comentar caso en sesión y ante hallazgos de Anatomía Patológica y toxicidad previa a quimioterapia, se solicita inmunoterapia con nivolumab como uso compasivo, iniciando ciclo 1 el 26 de septiembre de 2018. El día 5 de octubre consulta en el Servicio de Urgencias por cuadro de 3-4 días de evolución de astenia, debilidad muscular proximal, ptosis y diplopía. Exploración física » Consciente, orientada, afebril, eupneica en reposo. » NRL: funciones superiores conservadas. Pupilas "normocóricas" y normorreactivas, ptosis bilateral, oftalmoparesia para la aducción de ambos rectos internos en mirada lateral. » Balance motor: deltoides basal 4+/5 bilateral, tras 10 repeticiones fatiga y 4-/5 derecho y 3/5 izquierdo. Flexores de cuello basal 4/5, tras 5 repeticiones 3-/5. » Test del hielo en consulta positivo: mejoría notable de la oftalmoparesia y la ptosis. Pruebas complementarias » » Analítica con bioquímica, hemograma y coagulación rigurosamente normal. » » Se realiza TC de cráneo en el que no se objetivan hallazgos patológicos. » Se extrae analítica para estudio de perfil autoinmune (anticuerpos anti-AChR, anti-Musk y anti-músculo estriado). Diagnóstico Sospecha de miastenia gravis en paciente con timoma tras primer ciclo de nivolumab. Tratamiento » Piridostigmina 60 mg cada 8 horas. » Prednisona 60 mg cada 24 horas. Evolución Tras alta a domicilio con piridostigmina y corticoides, la paciente consulta de nuevo en Urgencias a los 5 días por el mismo cuadro, asociando, además, disnea y tos de 24-48 horas de evolución, sin fiebre. Se realiza angio-TC de tórax, la cual descarta progresión de la enfermedad, TEP, neumonía o neumonitis por toxicidad a inmunoterapia. Se traslada a sala de observación para iniciar tratamiento intravenoso con inmunoglobulinas y, ante la no mejoría del cuadro y la inestabilización de la paciente, termina ingresando en UCI. La paciente requiere intubación orotraqueal y tratamiento mediante plasmaféresis. Tras la primera semana, en la que no se había obtenido respuesta al tratamiento, se reciben los resultados de los anticuerpos solicitados: anti-AChR > 20 (0-0,45) y anti-Musk < 0,4 (0-0,4). En aquel momento se considera el diagnóstico de crisis miasténica Osserman grado 5 en relación a síndrome paraneoplásico del tumor primario, por lo que se presenta el caso en comité de tumores y se decide iniciar quimioterapia según esquema cisplatino, doxorrubicina y ciclofosfamida (CAP). Tras el primer ciclo, parece existir una ligera respuesta durante las primeras 48 horas. Sin embargo, y a pesar de un segundo ciclo de tratamiento, el cuadro continuaría progresando hasta finalmente producir la muerte de la paciente tras 38 días de ingreso en UCI.

[ "Anamnesis", "\n", "Mujer", "de", "39", "años", ",", "sin", "antecedentes", "de", "interés", ".", "\n", "En", "diciembre", "de", "2012", "inicia", "estudio", "en", "su", "país", "de", "origen", "por", "cuadro", "de", "disnea", "de", "un", "año", "de", "evolución", "asociado", "a", "dolor", "torácico", ".", "La", "TC", "objetiva", "un", "tumor", "de", "92", "x", "74", "mm", "que", "ocupa", "el", "mediastino", "anterior", "y", "que", "invade", "pericardio", ",", "porción", "ascendente", "del", "cayado", "aórtico", "y", "tronco", "de", "la", "arteria", "pulmonar", ".", "Se", "realiza", "resección", "tumoral", "parcial", "en", "enero", "de", "2013", ",", "obteniendo", "el", "diagnóstico", "anatomopatológico", "de", "timoma", "tipo", "B1", "con", "infiltración", "capsular", ".", "\n", "Posteriormente", ",", "la", "paciente", "es", "derivada", "a", "consultas", "de", "Oncología", ",", "donde", "se", "plantea", "quimioterapia", "complementaria", "según", "esquema", "Descripción", "epirrubicina-\"platamina", "\"", ",", "del", "que", "recibe", "4", "ciclos", "(", "último", "en", "mayo", "2013", ")", ".", "\n", "Tras", "progresión", "locorregional", "en", "septiembre", "2013", "y", "tras", "haber", "comentado", "caso", "en", "comité", "de", "tumores", "torácicos", ",", "se", "decide", "tratamiento", "con", "quimio", "-", "radioterapia", "concomitante", "con", "cisplatino", "(", "21", "sesiones", "de", "radioterapia", ")", ".", "Posteriormente", "la", "paciente", "inicia", "seguimiento", "y", "se", "traslada", "a", "nuestro", "país", ".", "\n", "En", "agosto", "de", "2014", "presenta", "nueva", "progresión", "pleural", "y", "pararrenal", "izquierda", ",", "iniciando", "nueva", "línea", "de", "tratamiento", "según", "esquema", "Ifosfamida", "1,5", "mg", "/", "m2", "durante", "5", "días", ",", "del", "que", "sólo", "pudo", "recibir", "un", "ciclo", "por", "neutropenia", "grado", "IV", "mantenida", ",", "requiriendo", "modificar", "esquema", "a", "TAXOL", "semanal", "(", "2", "on", "y", "1", "off", ")", "y", "del", "que", "recibe", "6", "ciclos", "con", "estabilización", "de", "la", "enfermedad", ".", "Posteriormente", "se", "realiza", "radioterapia", "de", "consolidación", "sobre", "lesiones", "pleurales", "y", "pararrenal", "izquierda", ",", "finalizando", "el", "tratamiento", "en", "agosto", "2015", ".", "\n", "En", "marzo", "de", "2016", "se", "evidencia", "en", "TC", "nueva", "recaída", "de", "la", "enfermedad", "a", "nivel", "pleural", "y", "se", "reinicia", "TAXOL", "semanal", ",", "recibiendo", "sólo", "3", "ciclos", "por", "presentar", "de", "nuevo", "toxicidad", "hematológica", ".", "Mantiene", "estabilidad", "de", "la", "enfermedad", "hasta", "enero", "de", "2017", ",", "donde", "progresa", "de", "nuevo", "a", "nivel", "pleural", "y", "ganglionar", ".", "Ante", "el", "antecedente", "de", "toxicidad", "previa", ",", "se", "inicia", "tratamiento", "con", "pemetrexed", "500", "mg", "/", "m2", "día", "1", "cada", "21", "días", ",", "recibiendo", "un", "total", "de", "6", "ciclos", "desde", "marzo", "a", "septiembre", "2017", "e", "iniciando", "de", "nuevo", "seguimiento", "(", "se", "decide", "stop", "de", "tratamiento", "por", "estabilidad", "de", "la", "enfermedad", "y", "toxicidad", "acumulada", ")", ".", "\n", "En", "diciembre", "2017", "se", "evidencia", "progresión", "de", "la", "enfermedad", "locorregional", "y", "pleural", "comentándose", "caso", "en", "comité", "de", "tumores", "y", "decidiéndose", "resección", "parcial", "de", "la", "enfermedad", ",", "que", "se", "realiza", "en", "febrero", "2018", ".", "La", "Anatomía", "Patológica", "fue", "de", "timoma", "tipo", "B2", "invasor", "con", "alto", "índice", "proliferativo", "(", "Ki", "67", "de", "40", "-", "50", "%", ")", "y", "alta", "expresión", "de", "PDL1", "(", "80", "%", ")", ".", "\n", "Tras", "la", "cirugía", ",", "la", "enfermedad", "se", "mantendría", "estable", "hasta", "septiembre", "de", "2018", ",", "donde", "se", "objetiva", "nueva", "progresión", "a", "nivel", "pleuropulmonar", ",", "pararrenal", "y", "nuevos", "implantes", "intraabdominales", ".", "Se", "vuelve", "a", "comentar", "caso", "en", "sesión", "y", "ante", "hallazgos", "de", "Anatomía", "Patológica", "y", "toxicidad", "previa", "a", "quimioterapia", ",", "se", "solicita", "inmunoterapia", "con", "nivolumab", "como", "uso", "compasivo", ",", "iniciando", "ciclo", "1", "el", "26", "de", "septiembre", "de", "2018", ".", "\n", "El", "día", "5", "de", "octubre", "consulta", "en", "el", "Servicio", "de", "Urgencias", "por", "cuadro", "de", "3", "-", "4", "días", "de", "evolución", "de", "astenia", ",", "debilidad", "muscular", "proximal", ",", "ptosis", "y", "diplopía", ".", "\n\n", "Exploración", "física", "\n", "»", "Consciente", ",", "orientada", ",", "afebril", ",", "eupneica", "en", "reposo", ".", "\n", "»", "NRL", ":", "funciones", "superiores", "conservadas", ".", "Pupilas", "\"", "normocóricas", "\"", "y", "normorreactivas", ",", "ptosis", "bilateral", ",", "oftalmoparesia", "para", "la", "aducción", "de", "ambos", "rectos", "internos", "en", "mirada", "lateral", ".", "\n", "»", "Balance", "motor", ":", "deltoides", "basal", "4+/5", "bilateral", ",", "tras", "10", "repeticiones", "fatiga", "y", "4-/5", "derecho", "y", "3/5", "izquierdo", ".", "Flexores", "de", "cuello", "basal", "4/5", ",", "tras", "5", "repeticiones", "3-/5", ".", "\n", "»", "Test", "del", "hielo", "en", "consulta", "positivo", ":", "mejoría", "notable", "de", "la", "oftalmoparesia", "y", "la", "ptosis", ".", "\n\n", "Pruebas", "complementarias", "\n", "»", "»", "Analítica", "con", "bioquímica", ",", "hemograma", "y", "coagulación", "rigurosamente", "normal", ".", "\n", "»", "»", "Se", "realiza", "TC", "de", "cráneo", "en", "el", "que", "no", "se", "objetivan", "hallazgos", "patológicos", ".", "\n", "»", "Se", "extrae", "analítica", "para", "estudio", "de", "perfil", "autoinmune", "(", "anticuerpos", "anti", "-", "AChR", ",", "anti", "-", "Musk", "y", "anti", "-", "músculo", "estriado", ")", ".", "\n\n", "Diagnóstico", "\n", "Sospecha", "de", "miastenia", "gravis", "en", "paciente", "con", "timoma", "tras", "primer", "ciclo", "de", "nivolumab", ".", "\n\n", "Tratamiento", "\n", "»", "Piridostigmina", "60", "mg", "cada", "8", "horas", ".", "\n", "»", "Prednisona", "60", "mg", "cada", "24", "horas", ".", "\n\n", "Evolución", "\n", "Tras", "alta", "a", "domicilio", "con", "piridostigmina", "y", "corticoides", ",", "la", "paciente", "consulta", "de", "nuevo", "en", "Urgencias", "a", "los", "5", "días", "por", "el", "mismo", "cuadro", ",", "asociando", ",", "además", ",", "disnea", "y", "tos", "de", "24", "-", "48", "horas", "de", "evolución", ",", "sin", "fiebre", ".", "Se", "realiza", "angio", "-", "TC", "de", "tórax", ",", "la", "cual", "descarta", "progresión", "de", "la", "enfermedad", ",", "TEP", ",", "neumonía", "o", "neumonitis", "por", "toxicidad", "a", "inmunoterapia", ".", "Se", "traslada", "a", "sala", "de", "observación", "para", "iniciar", "tratamiento", "intravenoso", "con", "inmunoglobulinas", "y", ",", "ante", "la", "no", "mejoría", "del", "cuadro", "y", "la", "inestabilización", "de", "la", "paciente", ",", "termina", "ingresando", "en", "UCI", ".", "\n", "La", "paciente", "requiere", "intubación", "orotraqueal", "y", "tratamiento", "mediante", "plasmaféresis", ".", "Tras", "la", "primera", "semana", ",", "en", "la", "que", "no", "se", "había", "obtenido", "respuesta", "al", "tratamiento", ",", "se", "reciben", "los", "resultados", "de", "los", "anticuerpos", "solicitados", ":", "anti", "-", "AChR", ">", "20", "(", "0", "-", "0,45", ")", "y", "anti", "-", "Musk", "<", "0,4", "(", "0", "-", "0,4", ")", ".", "\n", "En", "aquel", "momento", "se", "considera", "el", "diagnóstico", "de", "crisis", "miasténica", "Osserman", "grado", "5", "en", "relación", "a", "síndrome", "paraneoplásico", "del", "tumor", "primario", ",", "por", "lo", "que", "se", "presenta", "el", "caso", "en", "comité", "de", "tumores", "y", "se", "decide", "iniciar", "quimioterapia", "según", "esquema", "cisplatino", ",", "doxorrubicina", "y", "ciclofosfamida", "(", "CAP", ")", ".", "\n", "Tras", "el", "primer", "ciclo", ",", "parece", "existir", "una", "ligera", "respuesta", "durante", "las", "primeras", "48", "horas", ".", "Sin", "embargo", ",", "y", "a", "pesar", "de", "un", "segundo", "ciclo", "de", "tratamiento", ",", "el", "cuadro", "continuaría", "progresando", "hasta", "finalmente", "producir", "la", "muerte", "de", "la", "paciente", "tras", "38", "días", "de", "ingreso", "en", "UCI", "." ]

[ "MORFOLOGIA_NEOPLASIA" ]

tumor is a MORFOLOGIA_NEOPLASIA, tumoral is a MORFOLOGIA_NEOPLASIA, timoma tipo B1 is a MORFOLOGIA_NEOPLASIA, progresión pleural is a MORFOLOGIA_NEOPLASIA, lesiones pleurales is a MORFOLOGIA_NEOPLASIA, enfermedad a nivel pleural is a MORFOLOGIA_NEOPLASIA, enfermedad locorregional y pleural is a MORFOLOGIA_NEOPLASIA, timoma tipo B2 invasor is a MORFOLOGIA_NEOPLASIA, progresión a nivel pleuropulmonar is a MORFOLOGIA_NEOPLASIA, implantes intraabdominales is a MORFOLOGIA_NEOPLASIA, timoma is a MORFOLOGIA_NEOPLASIA, tumor is a MORFOLOGIA_NEOPLASIA

391_task1

Sentence: Anamnesis Mujer de 39 años, sin antecedentes de interés. En diciembre de 2012 inicia estudio en su país de origen por cuadro de disnea de un año de evolución asociado a dolor torácico. La TC objetiva un tumor de 92 x 74 mm que ocupa el mediastino anterior y que invade pericardio, porción ascendente del cayado aórtico y tronco de la arteria pulmonar. Se realiza resección tumoral parcial en enero de 2013, obteniendo el diagnóstico anatomopatológico de timoma tipo B1 con infiltración capsular. Posteriormente, la paciente es derivada a consultas de Oncología, donde se plantea quimioterapia complementaria según esquema Descripción epirrubicina-"platamina", del que recibe 4 ciclos (último en mayo 2013). Tras progresión locorregional en septiembre 2013 y tras haber comentado caso en comité de tumores torácicos, se decide tratamiento con quimio-radioterapia concomitante con cisplatino (21 sesiones de radioterapia). Posteriormente la paciente inicia seguimiento y se traslada a nuestro país. En agosto de 2014 presenta nueva progresión pleural y pararrenal izquierda, iniciando nueva línea de tratamiento según esquema Ifosfamida 1,5 mg/m2 durante 5 días, del que sólo pudo recibir un ciclo por neutropenia grado IV mantenida, requiriendo modificar esquema a TAXOL semanal (2 on y 1 off) y del que recibe 6 ciclos con estabilización de la enfermedad. Posteriormente se realiza radioterapia de consolidación sobre lesiones pleurales y pararrenal izquierda, finalizando el tratamiento en agosto 2015. En marzo de 2016 se evidencia en TC nueva recaída de la enfermedad a nivel pleural y se reinicia TAXOL semanal, recibiendo sólo 3 ciclos por presentar de nuevo toxicidad hematológica. Mantiene estabilidad de la enfermedad hasta enero de 2017, donde progresa de nuevo a nivel pleural y ganglionar. Ante el antecedente de toxicidad previa, se inicia tratamiento con pemetrexed 500 mg/m2 día 1 cada 21 días, recibiendo un total de 6 ciclos desde marzo a septiembre 2017 e iniciando de nuevo seguimiento (se decide stop de tratamiento por estabilidad de la enfermedad y toxicidad acumulada). En diciembre 2017 se evidencia progresión de la enfermedad locorregional y pleural comentándose caso en comité de tumores y decidiéndose resección parcial de la enfermedad, que se realiza en febrero 2018. La Anatomía Patológica fue de timoma tipo B2 invasor con alto índice proliferativo (Ki 67 de 40-50 %) y alta expresión de PDL1 (80 %). Tras la cirugía, la enfermedad se mantendría estable hasta septiembre de 2018, donde se objetiva nueva progresión a nivel pleuropulmonar, pararrenal y nuevos implantes intraabdominales. Se vuelve a comentar caso en sesión y ante hallazgos de Anatomía Patológica y toxicidad previa a quimioterapia, se solicita inmunoterapia con nivolumab como uso compasivo, iniciando ciclo 1 el 26 de septiembre de 2018. El día 5 de octubre consulta en el Servicio de Urgencias por cuadro de 3-4 días de evolución de astenia, debilidad muscular proximal, ptosis y diplopía. Exploración física » Consciente, orientada, afebril, eupneica en reposo. » NRL: funciones superiores conservadas. Pupilas "normocóricas" y normorreactivas, ptosis bilateral, oftalmoparesia para la aducción de ambos rectos internos en mirada lateral. » Balance motor: deltoides basal 4+/5 bilateral, tras 10 repeticiones fatiga y 4-/5 derecho y 3/5 izquierdo. Flexores de cuello basal 4/5, tras 5 repeticiones 3-/5. » Test del hielo en consulta positivo: mejoría notable de la oftalmoparesia y la ptosis. Pruebas complementarias » » Analítica con bioquímica, hemograma y coagulación rigurosamente normal. » » Se realiza TC de cráneo en el que no se objetivan hallazgos patológicos. » Se extrae analítica para estudio de perfil autoinmune (anticuerpos anti-AChR, anti-Musk y anti-músculo estriado). Diagnóstico Sospecha de miastenia gravis en paciente con timoma tras primer ciclo de nivolumab. Tratamiento » Piridostigmina 60 mg cada 8 horas. » Prednisona 60 mg cada 24 horas. Evolución Tras alta a domicilio con piridostigmina y corticoides, la paciente consulta de nuevo en Urgencias a los 5 días por el mismo cuadro, asociando, además, disnea y tos de 24-48 horas de evolución, sin fiebre. Se realiza angio-TC de tórax, la cual descarta progresión de la enfermedad, TEP, neumonía o neumonitis por toxicidad a inmunoterapia. Se traslada a sala de observación para iniciar tratamiento intravenoso con inmunoglobulinas y, ante la no mejoría del cuadro y la inestabilización de la paciente, termina ingresando en UCI. La paciente requiere intubación orotraqueal y tratamiento mediante plasmaféresis. Tras la primera semana, en la que no se había obtenido respuesta al tratamiento, se reciben los resultados de los anticuerpos solicitados: anti-AChR > 20 (0-0,45) y anti-Musk < 0,4 (0-0,4). En aquel momento se considera el diagnóstico de crisis miasténica Osserman grado 5 en relación a síndrome paraneoplásico del tumor primario, por lo que se presenta el caso en comité de tumores y se decide iniciar quimioterapia según esquema cisplatino, doxorrubicina y ciclofosfamida (CAP). Tras el primer ciclo, parece existir una ligera respuesta durante las primeras 48 horas. Sin embargo, y a pesar de un segundo ciclo de tratamiento, el cuadro continuaría progresando hasta finalmente producir la muerte de la paciente tras 38 días de ingreso en UCI. Instructions: please typing these entity words according to sentence: tumor, tumoral, timoma tipo B1, progresión pleural, lesiones pleurales, enfermedad a nivel pleural, enfermedad locorregional y pleural, timoma tipo B2 invasor, progresión a nivel pleuropulmonar, implantes intraabdominales, timoma, tumor Options: MORFOLOGIA_NEOPLASIA

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Anamnesis Mujer de 39 años, sin antecedentes de interés. En diciembre de 2012 inicia estudio en su país de origen por cuadro de disnea de un año de evolución asociado a dolor torácico. La TC objetiva un tumor de 92 x 74 mm que ocupa el mediastino anterior y que invade pericardio, porción ascendente del cayado aórtico y tronco de la arteria pulmonar. Se realiza resección tumoral parcial en enero de 2013, obteniendo el diagnóstico anatomopatológico de timoma tipo B1 con infiltración capsular. Posteriormente, la paciente es derivada a consultas de Oncología, donde se plantea quimioterapia complementaria según esquema Descripción epirrubicina-"platamina", del que recibe 4 ciclos (último en mayo 2013). Tras progresión locorregional en septiembre 2013 y tras haber comentado caso en comité de tumores torácicos, se decide tratamiento con quimio-radioterapia concomitante con cisplatino (21 sesiones de radioterapia). Posteriormente la paciente inicia seguimiento y se traslada a nuestro país. En agosto de 2014 presenta nueva progresión pleural y pararrenal izquierda, iniciando nueva línea de tratamiento según esquema Ifosfamida 1,5 mg/m2 durante 5 días, del que sólo pudo recibir un ciclo por neutropenia grado IV mantenida, requiriendo modificar esquema a TAXOL semanal (2 on y 1 off) y del que recibe 6 ciclos con estabilización de la enfermedad. Posteriormente se realiza radioterapia de consolidación sobre lesiones pleurales y pararrenal izquierda, finalizando el tratamiento en agosto 2015. En marzo de 2016 se evidencia en TC nueva recaída de la enfermedad a nivel pleural y se reinicia TAXOL semanal, recibiendo sólo 3 ciclos por presentar de nuevo toxicidad hematológica. Mantiene estabilidad de la enfermedad hasta enero de 2017, donde progresa de nuevo a nivel pleural y ganglionar. Ante el antecedente de toxicidad previa, se inicia tratamiento con pemetrexed 500 mg/m2 día 1 cada 21 días, recibiendo un total de 6 ciclos desde marzo a septiembre 2017 e iniciando de nuevo seguimiento (se decide stop de tratamiento por estabilidad de la enfermedad y toxicidad acumulada). En diciembre 2017 se evidencia progresión de la enfermedad locorregional y pleural comentándose caso en comité de tumores y decidiéndose resección parcial de la enfermedad, que se realiza en febrero 2018. La Anatomía Patológica fue de timoma tipo B2 invasor con alto índice proliferativo (Ki 67 de 40-50 %) y alta expresión de PDL1 (80 %). Tras la cirugía, la enfermedad se mantendría estable hasta septiembre de 2018, donde se objetiva nueva progresión a nivel pleuropulmonar, pararrenal y nuevos implantes intraabdominales. Se vuelve a comentar caso en sesión y ante hallazgos de Anatomía Patológica y toxicidad previa a quimioterapia, se solicita inmunoterapia con nivolumab como uso compasivo, iniciando ciclo 1 el 26 de septiembre de 2018. El día 5 de octubre consulta en el Servicio de Urgencias por cuadro de 3-4 días de evolución de astenia, debilidad muscular proximal, ptosis y diplopía. Exploración física » Consciente, orientada, afebril, eupneica en reposo. » NRL: funciones superiores conservadas. Pupilas "normocóricas" y normorreactivas, ptosis bilateral, oftalmoparesia para la aducción de ambos rectos internos en mirada lateral. » Balance motor: deltoides basal 4+/5 bilateral, tras 10 repeticiones fatiga y 4-/5 derecho y 3/5 izquierdo. Flexores de cuello basal 4/5, tras 5 repeticiones 3-/5. » Test del hielo en consulta positivo: mejoría notable de la oftalmoparesia y la ptosis. Pruebas complementarias » » Analítica con bioquímica, hemograma y coagulación rigurosamente normal. » » Se realiza TC de cráneo en el que no se objetivan hallazgos patológicos. » Se extrae analítica para estudio de perfil autoinmune (anticuerpos anti-AChR, anti-Musk y anti-músculo estriado). Diagnóstico Sospecha de miastenia gravis en paciente con timoma tras primer ciclo de nivolumab. Tratamiento » Piridostigmina 60 mg cada 8 horas. » Prednisona 60 mg cada 24 horas. Evolución Tras alta a domicilio con piridostigmina y corticoides, la paciente consulta de nuevo en Urgencias a los 5 días por el mismo cuadro, asociando, además, disnea y tos de 24-48 horas de evolución, sin fiebre. Se realiza angio-TC de tórax, la cual descarta progresión de la enfermedad, TEP, neumonía o neumonitis por toxicidad a inmunoterapia. Se traslada a sala de observación para iniciar tratamiento intravenoso con inmunoglobulinas y, ante la no mejoría del cuadro y la inestabilización de la paciente, termina ingresando en UCI. La paciente requiere intubación orotraqueal y tratamiento mediante plasmaféresis. Tras la primera semana, en la que no se había obtenido respuesta al tratamiento, se reciben los resultados de los anticuerpos solicitados: anti-AChR > 20 (0-0,45) y anti-Musk < 0,4 (0-0,4). En aquel momento se considera el diagnóstico de crisis miasténica Osserman grado 5 en relación a síndrome paraneoplásico del tumor primario, por lo que se presenta el caso en comité de tumores y se decide iniciar quimioterapia según esquema cisplatino, doxorrubicina y ciclofosfamida (CAP). Tras el primer ciclo, parece existir una ligera respuesta durante las primeras 48 horas. Sin embargo, y a pesar de un segundo ciclo de tratamiento, el cuadro continuaría progresando hasta finalmente producir la muerte de la paciente tras 38 días de ingreso en UCI.

[ "Anamnesis", "\n", "Mujer", "de", "39", "años", ",", "sin", "antecedentes", "de", "interés", ".", "\n", "En", "diciembre", "de", "2012", "inicia", "estudio", "en", "su", "país", "de", "origen", "por", "cuadro", "de", "disnea", "de", "un", "año", "de", "evolución", "asociado", "a", "dolor", "torácico", ".", "La", "TC", "objetiva", "un", "tumor", "de", "92", "x", "74", "mm", "que", "ocupa", "el", "mediastino", "anterior", "y", "que", "invade", "pericardio", ",", "porción", "ascendente", "del", "cayado", "aórtico", "y", "tronco", "de", "la", "arteria", "pulmonar", ".", "Se", "realiza", "resección", "tumoral", "parcial", "en", "enero", "de", "2013", ",", "obteniendo", "el", "diagnóstico", "anatomopatológico", "de", "timoma", "tipo", "B1", "con", "infiltración", "capsular", ".", "\n", "Posteriormente", ",", "la", "paciente", "es", "derivada", "a", "consultas", "de", "Oncología", ",", "donde", "se", "plantea", "quimioterapia", "complementaria", "según", "esquema", "Descripción", "epirrubicina-\"platamina", "\"", ",", "del", "que", "recibe", "4", "ciclos", "(", "último", "en", "mayo", "2013", ")", ".", "\n", "Tras", "progresión", "locorregional", "en", "septiembre", "2013", "y", "tras", "haber", "comentado", "caso", "en", "comité", "de", "tumores", "torácicos", ",", "se", "decide", "tratamiento", "con", "quimio", "-", "radioterapia", "concomitante", "con", "cisplatino", "(", "21", "sesiones", "de", "radioterapia", ")", ".", "Posteriormente", "la", "paciente", "inicia", "seguimiento", "y", "se", "traslada", "a", "nuestro", "país", ".", "\n", "En", "agosto", "de", "2014", "presenta", "nueva", "progresión", "pleural", "y", "pararrenal", "izquierda", ",", "iniciando", "nueva", "línea", "de", "tratamiento", "según", "esquema", "Ifosfamida", "1,5", "mg", "/", "m2", "durante", "5", "días", ",", "del", "que", "sólo", "pudo", "recibir", "un", "ciclo", "por", "neutropenia", "grado", "IV", "mantenida", ",", "requiriendo", "modificar", "esquema", "a", "TAXOL", "semanal", "(", "2", "on", "y", "1", "off", ")", "y", "del", "que", "recibe", "6", "ciclos", "con", "estabilización", "de", "la", "enfermedad", ".", "Posteriormente", "se", "realiza", "radioterapia", "de", "consolidación", "sobre", "lesiones", "pleurales", "y", "pararrenal", "izquierda", ",", "finalizando", "el", "tratamiento", "en", "agosto", "2015", ".", "\n", "En", "marzo", "de", "2016", "se", "evidencia", "en", "TC", "nueva", "recaída", "de", "la", "enfermedad", "a", "nivel", "pleural", "y", "se", "reinicia", "TAXOL", "semanal", ",", "recibiendo", "sólo", "3", "ciclos", "por", "presentar", "de", "nuevo", "toxicidad", "hematológica", ".", "Mantiene", "estabilidad", "de", "la", "enfermedad", "hasta", "enero", "de", "2017", ",", "donde", "progresa", "de", "nuevo", "a", "nivel", "pleural", "y", "ganglionar", ".", "Ante", "el", "antecedente", "de", "toxicidad", "previa", ",", "se", "inicia", "tratamiento", "con", "pemetrexed", "500", "mg", "/", "m2", "día", "1", "cada", "21", "días", ",", "recibiendo", "un", "total", "de", "6", "ciclos", "desde", "marzo", "a", "septiembre", "2017", "e", "iniciando", "de", "nuevo", "seguimiento", "(", "se", "decide", "stop", "de", "tratamiento", "por", "estabilidad", "de", "la", "enfermedad", "y", "toxicidad", "acumulada", ")", ".", "\n", "En", "diciembre", "2017", "se", "evidencia", "progresión", "de", "la", "enfermedad", "locorregional", "y", "pleural", "comentándose", "caso", "en", "comité", "de", "tumores", "y", "decidiéndose", "resección", "parcial", "de", "la", "enfermedad", ",", "que", "se", "realiza", "en", "febrero", "2018", ".", "La", "Anatomía", "Patológica", "fue", "de", "timoma", "tipo", "B2", "invasor", "con", "alto", "índice", "proliferativo", "(", "Ki", "67", "de", "40", "-", "50", "%", ")", "y", "alta", "expresión", "de", "PDL1", "(", "80", "%", ")", ".", "\n", "Tras", "la", "cirugía", ",", "la", "enfermedad", "se", "mantendría", "estable", "hasta", "septiembre", "de", "2018", ",", "donde", "se", "objetiva", "nueva", "progresión", "a", "nivel", "pleuropulmonar", ",", "pararrenal", "y", "nuevos", "implantes", "intraabdominales", ".", "Se", "vuelve", "a", "comentar", "caso", "en", "sesión", "y", "ante", "hallazgos", "de", "Anatomía", "Patológica", "y", "toxicidad", "previa", "a", "quimioterapia", ",", "se", "solicita", "inmunoterapia", "con", "nivolumab", "como", "uso", "compasivo", ",", "iniciando", "ciclo", "1", "el", "26", "de", "septiembre", "de", "2018", ".", "\n", "El", "día", "5", "de", "octubre", "consulta", "en", "el", "Servicio", "de", "Urgencias", "por", "cuadro", "de", "3", "-", "4", "días", "de", "evolución", "de", "astenia", ",", "debilidad", "muscular", "proximal", ",", "ptosis", "y", "diplopía", ".", "\n\n", "Exploración", "física", "\n", "»", "Consciente", ",", "orientada", ",", "afebril", ",", "eupneica", "en", "reposo", ".", "\n", "»", "NRL", ":", "funciones", "superiores", "conservadas", ".", "Pupilas", "\"", "normocóricas", "\"", "y", "normorreactivas", ",", "ptosis", "bilateral", ",", "oftalmoparesia", "para", "la", "aducción", "de", "ambos", "rectos", "internos", "en", "mirada", "lateral", ".", "\n", "»", "Balance", "motor", ":", "deltoides", "basal", "4+/5", "bilateral", ",", "tras", "10", "repeticiones", "fatiga", "y", "4-/5", "derecho", "y", "3/5", "izquierdo", ".", "Flexores", "de", "cuello", "basal", "4/5", ",", "tras", "5", "repeticiones", "3-/5", ".", "\n", "»", "Test", "del", "hielo", "en", "consulta", "positivo", ":", "mejoría", "notable", "de", "la", "oftalmoparesia", "y", "la", "ptosis", ".", "\n\n", "Pruebas", "complementarias", "\n", "»", "»", "Analítica", "con", "bioquímica", ",", "hemograma", "y", "coagulación", "rigurosamente", "normal", ".", "\n", "»", "»", "Se", "realiza", "TC", "de", "cráneo", "en", "el", "que", "no", "se", "objetivan", "hallazgos", "patológicos", ".", "\n", "»", "Se", "extrae", "analítica", "para", "estudio", "de", "perfil", "autoinmune", "(", "anticuerpos", "anti", "-", "AChR", ",", "anti", "-", "Musk", "y", "anti", "-", "músculo", "estriado", ")", ".", "\n\n", "Diagnóstico", "\n", "Sospecha", "de", "miastenia", "gravis", "en", "paciente", "con", "timoma", "tras", "primer", "ciclo", "de", "nivolumab", ".", "\n\n", "Tratamiento", "\n", "»", "Piridostigmina", "60", "mg", "cada", "8", "horas", ".", "\n", "»", "Prednisona", "60", "mg", "cada", "24", "horas", ".", "\n\n", "Evolución", "\n", "Tras", "alta", "a", "domicilio", "con", "piridostigmina", "y", "corticoides", ",", "la", "paciente", "consulta", "de", "nuevo", "en", "Urgencias", "a", "los", "5", "días", "por", "el", "mismo", "cuadro", ",", "asociando", ",", "además", ",", "disnea", "y", "tos", "de", "24", "-", "48", "horas", "de", "evolución", ",", "sin", "fiebre", ".", "Se", "realiza", "angio", "-", "TC", "de", "tórax", ",", "la", "cual", "descarta", "progresión", "de", "la", "enfermedad", ",", "TEP", ",", "neumonía", "o", "neumonitis", "por", "toxicidad", "a", "inmunoterapia", ".", "Se", "traslada", "a", "sala", "de", "observación", "para", "iniciar", "tratamiento", "intravenoso", "con", "inmunoglobulinas", "y", ",", "ante", "la", "no", "mejoría", "del", "cuadro", "y", "la", "inestabilización", "de", "la", "paciente", ",", "termina", "ingresando", "en", "UCI", ".", "\n", "La", "paciente", "requiere", "intubación", "orotraqueal", "y", "tratamiento", "mediante", "plasmaféresis", ".", "Tras", "la", "primera", "semana", ",", "en", "la", "que", "no", "se", "había", "obtenido", "respuesta", "al", "tratamiento", ",", "se", "reciben", "los", "resultados", "de", "los", "anticuerpos", "solicitados", ":", "anti", "-", "AChR", ">", "20", "(", "0", "-", "0,45", ")", "y", "anti", "-", "Musk", "<", "0,4", "(", "0", "-", "0,4", ")", ".", "\n", "En", "aquel", "momento", "se", "considera", "el", "diagnóstico", "de", "crisis", "miasténica", "Osserman", "grado", "5", "en", "relación", "a", "síndrome", "paraneoplásico", "del", "tumor", "primario", ",", "por", "lo", "que", "se", "presenta", "el", "caso", "en", "comité", "de", "tumores", "y", "se", "decide", "iniciar", "quimioterapia", "según", "esquema", "cisplatino", ",", "doxorrubicina", "y", "ciclofosfamida", "(", "CAP", ")", ".", "\n", "Tras", "el", "primer", "ciclo", ",", "parece", "existir", "una", "ligera", "respuesta", "durante", "las", "primeras", "48", "horas", ".", "Sin", "embargo", ",", "y", "a", "pesar", "de", "un", "segundo", "ciclo", "de", "tratamiento", ",", "el", "cuadro", "continuaría", "progresando", "hasta", "finalmente", "producir", "la", "muerte", "de", "la", "paciente", "tras", "38", "días", "de", "ingreso", "en", "UCI", "." ]

[ "MORFOLOGIA_NEOPLASIA" ]

tumor, tumoral, timoma tipo B1, progresión pleural, lesiones pleurales, enfermedad a nivel pleural, enfermedad locorregional y pleural, timoma tipo B2 invasor, progresión a nivel pleuropulmonar, implantes intraabdominales, timoma, tumor

391_task2

Sentence: Anamnesis Mujer de 39 años, sin antecedentes de interés. En diciembre de 2012 inicia estudio en su país de origen por cuadro de disnea de un año de evolución asociado a dolor torácico. La TC objetiva un tumor de 92 x 74 mm que ocupa el mediastino anterior y que invade pericardio, porción ascendente del cayado aórtico y tronco de la arteria pulmonar. Se realiza resección tumoral parcial en enero de 2013, obteniendo el diagnóstico anatomopatológico de timoma tipo B1 con infiltración capsular. Posteriormente, la paciente es derivada a consultas de Oncología, donde se plantea quimioterapia complementaria según esquema Descripción epirrubicina-"platamina", del que recibe 4 ciclos (último en mayo 2013). Tras progresión locorregional en septiembre 2013 y tras haber comentado caso en comité de tumores torácicos, se decide tratamiento con quimio-radioterapia concomitante con cisplatino (21 sesiones de radioterapia). Posteriormente la paciente inicia seguimiento y se traslada a nuestro país. En agosto de 2014 presenta nueva progresión pleural y pararrenal izquierda, iniciando nueva línea de tratamiento según esquema Ifosfamida 1,5 mg/m2 durante 5 días, del que sólo pudo recibir un ciclo por neutropenia grado IV mantenida, requiriendo modificar esquema a TAXOL semanal (2 on y 1 off) y del que recibe 6 ciclos con estabilización de la enfermedad. Posteriormente se realiza radioterapia de consolidación sobre lesiones pleurales y pararrenal izquierda, finalizando el tratamiento en agosto 2015. En marzo de 2016 se evidencia en TC nueva recaída de la enfermedad a nivel pleural y se reinicia TAXOL semanal, recibiendo sólo 3 ciclos por presentar de nuevo toxicidad hematológica. Mantiene estabilidad de la enfermedad hasta enero de 2017, donde progresa de nuevo a nivel pleural y ganglionar. Ante el antecedente de toxicidad previa, se inicia tratamiento con pemetrexed 500 mg/m2 día 1 cada 21 días, recibiendo un total de 6 ciclos desde marzo a septiembre 2017 e iniciando de nuevo seguimiento (se decide stop de tratamiento por estabilidad de la enfermedad y toxicidad acumulada). En diciembre 2017 se evidencia progresión de la enfermedad locorregional y pleural comentándose caso en comité de tumores y decidiéndose resección parcial de la enfermedad, que se realiza en febrero 2018. La Anatomía Patológica fue de timoma tipo B2 invasor con alto índice proliferativo (Ki 67 de 40-50 %) y alta expresión de PDL1 (80 %). Tras la cirugía, la enfermedad se mantendría estable hasta septiembre de 2018, donde se objetiva nueva progresión a nivel pleuropulmonar, pararrenal y nuevos implantes intraabdominales. Se vuelve a comentar caso en sesión y ante hallazgos de Anatomía Patológica y toxicidad previa a quimioterapia, se solicita inmunoterapia con nivolumab como uso compasivo, iniciando ciclo 1 el 26 de septiembre de 2018. El día 5 de octubre consulta en el Servicio de Urgencias por cuadro de 3-4 días de evolución de astenia, debilidad muscular proximal, ptosis y diplopía. Exploración física » Consciente, orientada, afebril, eupneica en reposo. » NRL: funciones superiores conservadas. Pupilas "normocóricas" y normorreactivas, ptosis bilateral, oftalmoparesia para la aducción de ambos rectos internos en mirada lateral. » Balance motor: deltoides basal 4+/5 bilateral, tras 10 repeticiones fatiga y 4-/5 derecho y 3/5 izquierdo. Flexores de cuello basal 4/5, tras 5 repeticiones 3-/5. » Test del hielo en consulta positivo: mejoría notable de la oftalmoparesia y la ptosis. Pruebas complementarias » » Analítica con bioquímica, hemograma y coagulación rigurosamente normal. » » Se realiza TC de cráneo en el que no se objetivan hallazgos patológicos. » Se extrae analítica para estudio de perfil autoinmune (anticuerpos anti-AChR, anti-Musk y anti-músculo estriado). Diagnóstico Sospecha de miastenia gravis en paciente con timoma tras primer ciclo de nivolumab. Tratamiento » Piridostigmina 60 mg cada 8 horas. » Prednisona 60 mg cada 24 horas. Evolución Tras alta a domicilio con piridostigmina y corticoides, la paciente consulta de nuevo en Urgencias a los 5 días por el mismo cuadro, asociando, además, disnea y tos de 24-48 horas de evolución, sin fiebre. Se realiza angio-TC de tórax, la cual descarta progresión de la enfermedad, TEP, neumonía o neumonitis por toxicidad a inmunoterapia. Se traslada a sala de observación para iniciar tratamiento intravenoso con inmunoglobulinas y, ante la no mejoría del cuadro y la inestabilización de la paciente, termina ingresando en UCI. La paciente requiere intubación orotraqueal y tratamiento mediante plasmaféresis. Tras la primera semana, en la que no se había obtenido respuesta al tratamiento, se reciben los resultados de los anticuerpos solicitados: anti-AChR > 20 (0-0,45) y anti-Musk < 0,4 (0-0,4). En aquel momento se considera el diagnóstico de crisis miasténica Osserman grado 5 en relación a síndrome paraneoplásico del tumor primario, por lo que se presenta el caso en comité de tumores y se decide iniciar quimioterapia según esquema cisplatino, doxorrubicina y ciclofosfamida (CAP). Tras el primer ciclo, parece existir una ligera respuesta durante las primeras 48 horas. Sin embargo, y a pesar de un segundo ciclo de tratamiento, el cuadro continuaría progresando hasta finalmente producir la muerte de la paciente tras 38 días de ingreso en UCI. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Anamnesis Mujer de 39 años, sin antecedentes de interés. En diciembre de 2012 inicia estudio en su país de origen por cuadro de disnea de un año de evolución asociado a dolor torácico. La TC objetiva un tumor de 92 x 74 mm que ocupa el mediastino anterior y que invade pericardio, porción ascendente del cayado aórtico y tronco de la arteria pulmonar. Se realiza resección tumoral parcial en enero de 2013, obteniendo el diagnóstico anatomopatológico de timoma tipo B1 con infiltración capsular. Posteriormente, la paciente es derivada a consultas de Oncología, donde se plantea quimioterapia complementaria según esquema Descripción epirrubicina-"platamina", del que recibe 4 ciclos (último en mayo 2013). Tras progresión locorregional en septiembre 2013 y tras haber comentado caso en comité de tumores torácicos, se decide tratamiento con quimio-radioterapia concomitante con cisplatino (21 sesiones de radioterapia). Posteriormente la paciente inicia seguimiento y se traslada a nuestro país. En agosto de 2014 presenta nueva progresión pleural y pararrenal izquierda, iniciando nueva línea de tratamiento según esquema Ifosfamida 1,5 mg/m2 durante 5 días, del que sólo pudo recibir un ciclo por neutropenia grado IV mantenida, requiriendo modificar esquema a TAXOL semanal (2 on y 1 off) y del que recibe 6 ciclos con estabilización de la enfermedad. Posteriormente se realiza radioterapia de consolidación sobre lesiones pleurales y pararrenal izquierda, finalizando el tratamiento en agosto 2015. En marzo de 2016 se evidencia en TC nueva recaída de la enfermedad a nivel pleural y se reinicia TAXOL semanal, recibiendo sólo 3 ciclos por presentar de nuevo toxicidad hematológica. Mantiene estabilidad de la enfermedad hasta enero de 2017, donde progresa de nuevo a nivel pleural y ganglionar. Ante el antecedente de toxicidad previa, se inicia tratamiento con pemetrexed 500 mg/m2 día 1 cada 21 días, recibiendo un total de 6 ciclos desde marzo a septiembre 2017 e iniciando de nuevo seguimiento (se decide stop de tratamiento por estabilidad de la enfermedad y toxicidad acumulada). En diciembre 2017 se evidencia progresión de la enfermedad locorregional y pleural comentándose caso en comité de tumores y decidiéndose resección parcial de la enfermedad, que se realiza en febrero 2018. La Anatomía Patológica fue de timoma tipo B2 invasor con alto índice proliferativo (Ki 67 de 40-50 %) y alta expresión de PDL1 (80 %). Tras la cirugía, la enfermedad se mantendría estable hasta septiembre de 2018, donde se objetiva nueva progresión a nivel pleuropulmonar, pararrenal y nuevos implantes intraabdominales. Se vuelve a comentar caso en sesión y ante hallazgos de Anatomía Patológica y toxicidad previa a quimioterapia, se solicita inmunoterapia con nivolumab como uso compasivo, iniciando ciclo 1 el 26 de septiembre de 2018. El día 5 de octubre consulta en el Servicio de Urgencias por cuadro de 3-4 días de evolución de astenia, debilidad muscular proximal, ptosis y diplopía. Exploración física » Consciente, orientada, afebril, eupneica en reposo. » NRL: funciones superiores conservadas. Pupilas "normocóricas" y normorreactivas, ptosis bilateral, oftalmoparesia para la aducción de ambos rectos internos en mirada lateral. » Balance motor: deltoides basal 4+/5 bilateral, tras 10 repeticiones fatiga y 4-/5 derecho y 3/5 izquierdo. Flexores de cuello basal 4/5, tras 5 repeticiones 3-/5. » Test del hielo en consulta positivo: mejoría notable de la oftalmoparesia y la ptosis. Pruebas complementarias » » Analítica con bioquímica, hemograma y coagulación rigurosamente normal. » » Se realiza TC de cráneo en el que no se objetivan hallazgos patológicos. » Se extrae analítica para estudio de perfil autoinmune (anticuerpos anti-AChR, anti-Musk y anti-músculo estriado). Diagnóstico Sospecha de miastenia gravis en paciente con timoma tras primer ciclo de nivolumab. Tratamiento » Piridostigmina 60 mg cada 8 horas. » Prednisona 60 mg cada 24 horas. Evolución Tras alta a domicilio con piridostigmina y corticoides, la paciente consulta de nuevo en Urgencias a los 5 días por el mismo cuadro, asociando, además, disnea y tos de 24-48 horas de evolución, sin fiebre. Se realiza angio-TC de tórax, la cual descarta progresión de la enfermedad, TEP, neumonía o neumonitis por toxicidad a inmunoterapia. Se traslada a sala de observación para iniciar tratamiento intravenoso con inmunoglobulinas y, ante la no mejoría del cuadro y la inestabilización de la paciente, termina ingresando en UCI. La paciente requiere intubación orotraqueal y tratamiento mediante plasmaféresis. Tras la primera semana, en la que no se había obtenido respuesta al tratamiento, se reciben los resultados de los anticuerpos solicitados: anti-AChR > 20 (0-0,45) y anti-Musk < 0,4 (0-0,4). En aquel momento se considera el diagnóstico de crisis miasténica Osserman grado 5 en relación a síndrome paraneoplásico del tumor primario, por lo que se presenta el caso en comité de tumores y se decide iniciar quimioterapia según esquema cisplatino, doxorrubicina y ciclofosfamida (CAP). Tras el primer ciclo, parece existir una ligera respuesta durante las primeras 48 horas. Sin embargo, y a pesar de un segundo ciclo de tratamiento, el cuadro continuaría progresando hasta finalmente producir la muerte de la paciente tras 38 días de ingreso en UCI.

[ "Anamnesis", "\n", "Mujer", "de", "39", "años", ",", "sin", "antecedentes", "de", "interés", ".", "\n", "En", "diciembre", "de", "2012", "inicia", "estudio", "en", "su", "país", "de", "origen", "por", "cuadro", "de", "disnea", "de", "un", "año", "de", "evolución", "asociado", "a", "dolor", "torácico", ".", "La", "TC", "objetiva", "un", "tumor", "de", "92", "x", "74", "mm", "que", "ocupa", "el", "mediastino", "anterior", "y", "que", "invade", "pericardio", ",", "porción", "ascendente", "del", "cayado", "aórtico", "y", "tronco", "de", "la", "arteria", "pulmonar", ".", "Se", "realiza", "resección", "tumoral", "parcial", "en", "enero", "de", "2013", ",", "obteniendo", "el", "diagnóstico", "anatomopatológico", "de", "timoma", "tipo", "B1", "con", "infiltración", "capsular", ".", "\n", "Posteriormente", ",", "la", "paciente", "es", "derivada", "a", "consultas", "de", "Oncología", ",", "donde", "se", "plantea", "quimioterapia", "complementaria", "según", "esquema", "Descripción", "epirrubicina-\"platamina", "\"", ",", "del", "que", "recibe", "4", "ciclos", "(", "último", "en", "mayo", "2013", ")", ".", "\n", "Tras", "progresión", "locorregional", "en", "septiembre", "2013", "y", "tras", "haber", "comentado", "caso", "en", "comité", "de", "tumores", "torácicos", ",", "se", "decide", "tratamiento", "con", "quimio", "-", "radioterapia", "concomitante", "con", "cisplatino", "(", "21", "sesiones", "de", "radioterapia", ")", ".", "Posteriormente", "la", "paciente", "inicia", "seguimiento", "y", "se", "traslada", "a", "nuestro", "país", ".", "\n", "En", "agosto", "de", "2014", "presenta", "nueva", "progresión", "pleural", "y", "pararrenal", "izquierda", ",", "iniciando", "nueva", "línea", "de", "tratamiento", "según", "esquema", "Ifosfamida", "1,5", "mg", "/", "m2", "durante", "5", "días", ",", "del", "que", "sólo", "pudo", "recibir", "un", "ciclo", "por", "neutropenia", "grado", "IV", "mantenida", ",", "requiriendo", "modificar", "esquema", "a", "TAXOL", "semanal", "(", "2", "on", "y", "1", "off", ")", "y", "del", "que", "recibe", "6", "ciclos", "con", "estabilización", "de", "la", "enfermedad", ".", "Posteriormente", "se", "realiza", "radioterapia", "de", "consolidación", "sobre", "lesiones", "pleurales", "y", "pararrenal", "izquierda", ",", "finalizando", "el", "tratamiento", "en", "agosto", "2015", ".", "\n", "En", "marzo", "de", "2016", "se", "evidencia", "en", "TC", "nueva", "recaída", "de", "la", "enfermedad", "a", "nivel", "pleural", "y", "se", "reinicia", "TAXOL", "semanal", ",", "recibiendo", "sólo", "3", "ciclos", "por", "presentar", "de", "nuevo", "toxicidad", "hematológica", ".", "Mantiene", "estabilidad", "de", "la", "enfermedad", "hasta", "enero", "de", "2017", ",", "donde", "progresa", "de", "nuevo", "a", "nivel", "pleural", "y", "ganglionar", ".", "Ante", "el", "antecedente", "de", "toxicidad", "previa", ",", "se", "inicia", "tratamiento", "con", "pemetrexed", "500", "mg", "/", "m2", "día", "1", "cada", "21", "días", ",", "recibiendo", "un", "total", "de", "6", "ciclos", "desde", "marzo", "a", "septiembre", "2017", "e", "iniciando", "de", "nuevo", "seguimiento", "(", "se", "decide", "stop", "de", "tratamiento", "por", "estabilidad", "de", "la", "enfermedad", "y", "toxicidad", "acumulada", ")", ".", "\n", "En", "diciembre", "2017", "se", "evidencia", "progresión", "de", "la", "enfermedad", "locorregional", "y", "pleural", "comentándose", "caso", "en", "comité", "de", "tumores", "y", "decidiéndose", "resección", "parcial", "de", "la", "enfermedad", ",", "que", "se", "realiza", "en", "febrero", "2018", ".", "La", "Anatomía", "Patológica", "fue", "de", "timoma", "tipo", "B2", "invasor", "con", "alto", "índice", "proliferativo", "(", "Ki", "67", "de", "40", "-", "50", "%", ")", "y", "alta", "expresión", "de", "PDL1", "(", "80", "%", ")", ".", "\n", "Tras", "la", "cirugía", ",", "la", "enfermedad", "se", "mantendría", "estable", "hasta", "septiembre", "de", "2018", ",", "donde", "se", "objetiva", "nueva", "progresión", "a", "nivel", "pleuropulmonar", ",", "pararrenal", "y", "nuevos", "implantes", "intraabdominales", ".", "Se", "vuelve", "a", "comentar", "caso", "en", "sesión", "y", "ante", "hallazgos", "de", "Anatomía", "Patológica", "y", "toxicidad", "previa", "a", "quimioterapia", ",", "se", "solicita", "inmunoterapia", "con", "nivolumab", "como", "uso", "compasivo", ",", "iniciando", "ciclo", "1", "el", "26", "de", "septiembre", "de", "2018", ".", "\n", "El", "día", "5", "de", "octubre", "consulta", "en", "el", "Servicio", "de", "Urgencias", "por", "cuadro", "de", "3", "-", "4", "días", "de", "evolución", "de", "astenia", ",", "debilidad", "muscular", "proximal", ",", "ptosis", "y", "diplopía", ".", "\n\n", "Exploración", "física", "\n", "»", "Consciente", ",", "orientada", ",", "afebril", ",", "eupneica", "en", "reposo", ".", "\n", "»", "NRL", ":", "funciones", "superiores", "conservadas", ".", "Pupilas", "\"", "normocóricas", "\"", "y", "normorreactivas", ",", "ptosis", "bilateral", ",", "oftalmoparesia", "para", "la", "aducción", "de", "ambos", "rectos", "internos", "en", "mirada", "lateral", ".", "\n", "»", "Balance", "motor", ":", "deltoides", "basal", "4+/5", "bilateral", ",", "tras", "10", "repeticiones", "fatiga", "y", "4-/5", "derecho", "y", "3/5", "izquierdo", ".", "Flexores", "de", "cuello", "basal", "4/5", ",", "tras", "5", "repeticiones", "3-/5", ".", "\n", "»", "Test", "del", "hielo", "en", "consulta", "positivo", ":", "mejoría", "notable", "de", "la", "oftalmoparesia", "y", "la", "ptosis", ".", "\n\n", "Pruebas", "complementarias", "\n", "»", "»", "Analítica", "con", "bioquímica", ",", "hemograma", "y", "coagulación", "rigurosamente", "normal", ".", "\n", "»", "»", "Se", "realiza", "TC", "de", "cráneo", "en", "el", "que", "no", "se", "objetivan", "hallazgos", "patológicos", ".", "\n", "»", "Se", "extrae", "analítica", "para", "estudio", "de", "perfil", "autoinmune", "(", "anticuerpos", "anti", "-", "AChR", ",", "anti", "-", "Musk", "y", "anti", "-", "músculo", "estriado", ")", ".", "\n\n", "Diagnóstico", "\n", "Sospecha", "de", "miastenia", "gravis", "en", "paciente", "con", "timoma", "tras", "primer", "ciclo", "de", "nivolumab", ".", "\n\n", "Tratamiento", "\n", "»", "Piridostigmina", "60", "mg", "cada", "8", "horas", ".", "\n", "»", "Prednisona", "60", "mg", "cada", "24", "horas", ".", "\n\n", "Evolución", "\n", "Tras", "alta", "a", "domicilio", "con", "piridostigmina", "y", "corticoides", ",", "la", "paciente", "consulta", "de", "nuevo", "en", "Urgencias", "a", "los", "5", "días", "por", "el", "mismo", "cuadro", ",", "asociando", ",", "además", ",", "disnea", "y", "tos", "de", "24", "-", "48", "horas", "de", "evolución", ",", "sin", "fiebre", ".", "Se", "realiza", "angio", "-", "TC", "de", "tórax", ",", "la", "cual", "descarta", "progresión", "de", "la", "enfermedad", ",", "TEP", ",", "neumonía", "o", "neumonitis", "por", "toxicidad", "a", "inmunoterapia", ".", "Se", "traslada", "a", "sala", "de", "observación", "para", "iniciar", "tratamiento", "intravenoso", "con", "inmunoglobulinas", "y", ",", "ante", "la", "no", "mejoría", "del", "cuadro", "y", "la", "inestabilización", "de", "la", "paciente", ",", "termina", "ingresando", "en", "UCI", ".", "\n", "La", "paciente", "requiere", "intubación", "orotraqueal", "y", "tratamiento", "mediante", "plasmaféresis", ".", "Tras", "la", "primera", "semana", ",", "en", "la", "que", "no", "se", "había", "obtenido", "respuesta", "al", "tratamiento", ",", "se", "reciben", "los", "resultados", "de", "los", "anticuerpos", "solicitados", ":", "anti", "-", "AChR", ">", "20", "(", "0", "-", "0,45", ")", "y", "anti", "-", "Musk", "<", "0,4", "(", "0", "-", "0,4", ")", ".", "\n", "En", "aquel", "momento", "se", "considera", "el", "diagnóstico", "de", "crisis", "miasténica", "Osserman", "grado", "5", "en", "relación", "a", "síndrome", "paraneoplásico", "del", "tumor", "primario", ",", "por", "lo", "que", "se", "presenta", "el", "caso", "en", "comité", "de", "tumores", "y", "se", "decide", "iniciar", "quimioterapia", "según", "esquema", "cisplatino", ",", "doxorrubicina", "y", "ciclofosfamida", "(", "CAP", ")", ".", "\n", "Tras", "el", "primer", "ciclo", ",", "parece", "existir", "una", "ligera", "respuesta", "durante", "las", "primeras", "48", "horas", ".", "Sin", "embargo", ",", "y", "a", "pesar", "de", "un", "segundo", "ciclo", "de", "tratamiento", ",", "el", "cuadro", "continuaría", "progresando", "hasta", "finalmente", "producir", "la", "muerte", "de", "la", "paciente", "tras", "38", "días", "de", "ingreso", "en", "UCI", "." ]

[ "MORFOLOGIA_NEOPLASIA" ]

Epithelabloesung is an umlsterm, Frauen is an umlsterm, Mann is an umlsterm, Gebrauch is an umlsterm, Zahnpasta is an umlsterm, Samtweiss is an umlsterm, Methoden is an umlsterm, Patienten is an umlsterm, Epithels is an umlsterm, Schleimhaut is an umlsterm, Gingiva is an umlsterm, Membranen is an umlsterm, Blutungen is an umlsterm, Epithelproben is an umlsterm, Membranen is an umlsterm, Epithels is an umlsterm, Patienten is an umlsterm, Natriumlaurylsulfat is an umlsterm

MundKieferGesichtschirurgie.90030078.ger.abstr_task0

Sentence: Fragestellung : Ein ungewoehnliches klinisches Bild von Epithelabloesung bei 6 Frauen und 1 Mann nach Gebrauch einer neuen Zahnpasta Odol-med 3 Samtweiss wird beschrieben . Material und Methoden : 7 Patienten im Alter zwischen 31 und 72 Jahren litten an einer allgemeinen Abloesung des Epithels der oralen Schleimhaut . In allen Bereichen der Mundhoehle einschliesslich der Gingiva propria wurde eine leukoedemartige Schicht gefunden , die sich spontan abloeste oder in Membranen von 1 cm2 leicht mit der Pinzette abgeloest werden konnte . Es traten keine Blutungen , jedoch in 2 Faellen schmerzhafte Erosionen auf . Epithelproben wurden histologisch und mikrobiologisch , insbesondere auf Candidaspezies untersucht . Ergebnisse und Diskussion : Die abgeloesten Membranen erwiesen sich histologisch als die obersten 2-15 Zellschichten des Epithels ohne Dysplasie oder Vesikel . Eine normale Flora wurde isoliert . Alle Patienten hatten 2-4 Wochen zuvor begonnen , die neue Zahnpaste zu gebrauchen . Nach Absetzen des Praeparats verschwanden die Veraenderungen . Moegliche Ursachen der Epitheliolyse ( Natriumlaurylsulfat Natriumtripolyphosphat ) , werden diskutiert . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]

Fragestellung : Ein ungewoehnliches klinisches Bild von Epithelabloesung bei 6 Frauen und 1 Mann nach Gebrauch einer neuen Zahnpasta Odol-med 3 Samtweiss wird beschrieben . Material und Methoden : 7 Patienten im Alter zwischen 31 und 72 Jahren litten an einer allgemeinen Abloesung des Epithels der oralen Schleimhaut . In allen Bereichen der Mundhoehle einschliesslich der Gingiva propria wurde eine leukoedemartige Schicht gefunden , die sich spontan abloeste oder in Membranen von 1 cm2 leicht mit der Pinzette abgeloest werden konnte . Es traten keine Blutungen , jedoch in 2 Faellen schmerzhafte Erosionen auf . Epithelproben wurden histologisch und mikrobiologisch , insbesondere auf Candidaspezies untersucht . Ergebnisse und Diskussion : Die abgeloesten Membranen erwiesen sich histologisch als die obersten 2-15 Zellschichten des Epithels ohne Dysplasie oder Vesikel . Eine normale Flora wurde isoliert . Alle Patienten hatten 2-4 Wochen zuvor begonnen , die neue Zahnpaste zu gebrauchen . Nach Absetzen des Praeparats verschwanden die Veraenderungen . Moegliche Ursachen der Epitheliolyse ( Natriumlaurylsulfat Natriumtripolyphosphat ) , werden diskutiert .

[ "Fragestellung", ":", "Ein", "ungewoehnliches", "klinisches", "Bild", "von", "Epithelabloesung", "bei", "6", "Frauen", "und", "1", "Mann", "nach", "Gebrauch", "einer", "neuen", "Zahnpasta", "Odol", "-", "med", "3", "Samtweiss", "wird", "beschrieben", ".", "Material", "und", "Methoden", ":", "7", "Patienten", "im", "Alter", "zwischen", "31", "und", "72", "Jahren", "litten", "an", "einer", "allgemeinen", "Abloesung", "des", "Epithels", "der", "oralen", "Schleimhaut", ".", "In", "allen", "Bereichen", "der", "Mundhoehle", "einschliesslich", "der", "Gingiva", "propria", "wurde", "eine", "leukoedemartige", "Schicht", "gefunden", ",", "die", "sich", "spontan", "abloeste", "oder", "in", "Membranen", "von", "1", "cm2", "leicht", "mit", "der", "Pinzette", "abgeloest", "werden", "konnte", ".", "Es", "traten", "keine", "Blutungen", ",", "jedoch", "in", "2", "Faellen", "schmerzhafte", "Erosionen", "auf", ".", "Epithelproben", "wurden", "histologisch", "und", "mikrobiologisch", ",", "insbesondere", "auf", "Candidaspezies", "untersucht", ".", "Ergebnisse", "und", "Diskussion", ":", "Die", "abgeloesten", "Membranen", "erwiesen", "sich", "histologisch", "als", "die", "obersten", "2", "-", "15", "Zellschichten", "des", "Epithels", "ohne", "Dysplasie", "oder", "Vesikel", ".", "Eine", "normale", "Flora", "wurde", "isoliert", ".", "Alle", "Patienten", "hatten", "2", "-", "4", "Wochen", "zuvor", "begonnen", ",", "die", "neue", "Zahnpaste", "zu", "gebrauchen", ".", "Nach", "Absetzen", "des", "Praeparats", "verschwanden", "die", "Veraenderungen", ".", "Moegliche", "Ursachen", "der", "Epitheliolyse", "(", "Natriumlaurylsulfat", "Natriumtripolyphosphat", ")", ",", "werden", "diskutiert", "." ]

[ "umlsterm" ]

Epithelabloesung is an umlsterm, Frauen is an umlsterm, Mann is an umlsterm, Gebrauch is an umlsterm, Zahnpasta is an umlsterm, Samtweiss is an umlsterm, Methoden is an umlsterm, Patienten is an umlsterm, Epithels is an umlsterm, Schleimhaut is an umlsterm, Gingiva is an umlsterm, Membranen is an umlsterm, Blutungen is an umlsterm, Epithelproben is an umlsterm, Membranen is an umlsterm, Epithels is an umlsterm, Patienten is an umlsterm, Natriumlaurylsulfat is an umlsterm

MundKieferGesichtschirurgie.90030078.ger.abstr_task1

Sentence: Fragestellung : Ein ungewoehnliches klinisches Bild von Epithelabloesung bei 6 Frauen und 1 Mann nach Gebrauch einer neuen Zahnpasta Odol-med 3 Samtweiss wird beschrieben . Material und Methoden : 7 Patienten im Alter zwischen 31 und 72 Jahren litten an einer allgemeinen Abloesung des Epithels der oralen Schleimhaut . In allen Bereichen der Mundhoehle einschliesslich der Gingiva propria wurde eine leukoedemartige Schicht gefunden , die sich spontan abloeste oder in Membranen von 1 cm2 leicht mit der Pinzette abgeloest werden konnte . Es traten keine Blutungen , jedoch in 2 Faellen schmerzhafte Erosionen auf . Epithelproben wurden histologisch und mikrobiologisch , insbesondere auf Candidaspezies untersucht . Ergebnisse und Diskussion : Die abgeloesten Membranen erwiesen sich histologisch als die obersten 2-15 Zellschichten des Epithels ohne Dysplasie oder Vesikel . Eine normale Flora wurde isoliert . Alle Patienten hatten 2-4 Wochen zuvor begonnen , die neue Zahnpaste zu gebrauchen . Nach Absetzen des Praeparats verschwanden die Veraenderungen . Moegliche Ursachen der Epitheliolyse ( Natriumlaurylsulfat Natriumtripolyphosphat ) , werden diskutiert . Instructions: please typing these entity words according to sentence: Epithelabloesung, Frauen, Mann, Gebrauch, Zahnpasta, Samtweiss, Methoden, Patienten, Epithels, Schleimhaut, Gingiva, Membranen, Blutungen, Epithelproben, Membranen, Epithels, Patienten, Natriumlaurylsulfat Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]

Fragestellung : Ein ungewoehnliches klinisches Bild von Epithelabloesung bei 6 Frauen und 1 Mann nach Gebrauch einer neuen Zahnpasta Odol-med 3 Samtweiss wird beschrieben . Material und Methoden : 7 Patienten im Alter zwischen 31 und 72 Jahren litten an einer allgemeinen Abloesung des Epithels der oralen Schleimhaut . In allen Bereichen der Mundhoehle einschliesslich der Gingiva propria wurde eine leukoedemartige Schicht gefunden , die sich spontan abloeste oder in Membranen von 1 cm2 leicht mit der Pinzette abgeloest werden konnte . Es traten keine Blutungen , jedoch in 2 Faellen schmerzhafte Erosionen auf . Epithelproben wurden histologisch und mikrobiologisch , insbesondere auf Candidaspezies untersucht . Ergebnisse und Diskussion : Die abgeloesten Membranen erwiesen sich histologisch als die obersten 2-15 Zellschichten des Epithels ohne Dysplasie oder Vesikel . Eine normale Flora wurde isoliert . Alle Patienten hatten 2-4 Wochen zuvor begonnen , die neue Zahnpaste zu gebrauchen . Nach Absetzen des Praeparats verschwanden die Veraenderungen . Moegliche Ursachen der Epitheliolyse ( Natriumlaurylsulfat Natriumtripolyphosphat ) , werden diskutiert .

[ "Fragestellung", ":", "Ein", "ungewoehnliches", "klinisches", "Bild", "von", "Epithelabloesung", "bei", "6", "Frauen", "und", "1", "Mann", "nach", "Gebrauch", "einer", "neuen", "Zahnpasta", "Odol", "-", "med", "3", "Samtweiss", "wird", "beschrieben", ".", "Material", "und", "Methoden", ":", "7", "Patienten", "im", "Alter", "zwischen", "31", "und", "72", "Jahren", "litten", "an", "einer", "allgemeinen", "Abloesung", "des", "Epithels", "der", "oralen", "Schleimhaut", ".", "In", "allen", "Bereichen", "der", "Mundhoehle", "einschliesslich", "der", "Gingiva", "propria", "wurde", "eine", "leukoedemartige", "Schicht", "gefunden", ",", "die", "sich", "spontan", "abloeste", "oder", "in", "Membranen", "von", "1", "cm2", "leicht", "mit", "der", "Pinzette", "abgeloest", "werden", "konnte", ".", "Es", "traten", "keine", "Blutungen", ",", "jedoch", "in", "2", "Faellen", "schmerzhafte", "Erosionen", "auf", ".", "Epithelproben", "wurden", "histologisch", "und", "mikrobiologisch", ",", "insbesondere", "auf", "Candidaspezies", "untersucht", ".", "Ergebnisse", "und", "Diskussion", ":", "Die", "abgeloesten", "Membranen", "erwiesen", "sich", "histologisch", "als", "die", "obersten", "2", "-", "15", "Zellschichten", "des", "Epithels", "ohne", "Dysplasie", "oder", "Vesikel", ".", "Eine", "normale", "Flora", "wurde", "isoliert", ".", "Alle", "Patienten", "hatten", "2", "-", "4", "Wochen", "zuvor", "begonnen", ",", "die", "neue", "Zahnpaste", "zu", "gebrauchen", ".", "Nach", "Absetzen", "des", "Praeparats", "verschwanden", "die", "Veraenderungen", ".", "Moegliche", "Ursachen", "der", "Epitheliolyse", "(", "Natriumlaurylsulfat", "Natriumtripolyphosphat", ")", ",", "werden", "diskutiert", "." ]

[ "umlsterm" ]

Epithelabloesung, Frauen, Mann, Gebrauch, Zahnpasta, Samtweiss, Methoden, Patienten, Epithels, Schleimhaut, Gingiva, Membranen, Blutungen, Epithelproben, Membranen, Epithels, Patienten, Natriumlaurylsulfat

MundKieferGesichtschirurgie.90030078.ger.abstr_task2

Sentence: Fragestellung : Ein ungewoehnliches klinisches Bild von Epithelabloesung bei 6 Frauen und 1 Mann nach Gebrauch einer neuen Zahnpasta Odol-med 3 Samtweiss wird beschrieben . Material und Methoden : 7 Patienten im Alter zwischen 31 und 72 Jahren litten an einer allgemeinen Abloesung des Epithels der oralen Schleimhaut . In allen Bereichen der Mundhoehle einschliesslich der Gingiva propria wurde eine leukoedemartige Schicht gefunden , die sich spontan abloeste oder in Membranen von 1 cm2 leicht mit der Pinzette abgeloest werden konnte . Es traten keine Blutungen , jedoch in 2 Faellen schmerzhafte Erosionen auf . Epithelproben wurden histologisch und mikrobiologisch , insbesondere auf Candidaspezies untersucht . Ergebnisse und Diskussion : Die abgeloesten Membranen erwiesen sich histologisch als die obersten 2-15 Zellschichten des Epithels ohne Dysplasie oder Vesikel . Eine normale Flora wurde isoliert . Alle Patienten hatten 2-4 Wochen zuvor begonnen , die neue Zahnpaste zu gebrauchen . Nach Absetzen des Praeparats verschwanden die Veraenderungen . Moegliche Ursachen der Epitheliolyse ( Natriumlaurylsulfat Natriumtripolyphosphat ) , werden diskutiert . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]

Fragestellung : Ein ungewoehnliches klinisches Bild von Epithelabloesung bei 6 Frauen und 1 Mann nach Gebrauch einer neuen Zahnpasta Odol-med 3 Samtweiss wird beschrieben . Material und Methoden : 7 Patienten im Alter zwischen 31 und 72 Jahren litten an einer allgemeinen Abloesung des Epithels der oralen Schleimhaut . In allen Bereichen der Mundhoehle einschliesslich der Gingiva propria wurde eine leukoedemartige Schicht gefunden , die sich spontan abloeste oder in Membranen von 1 cm2 leicht mit der Pinzette abgeloest werden konnte . Es traten keine Blutungen , jedoch in 2 Faellen schmerzhafte Erosionen auf . Epithelproben wurden histologisch und mikrobiologisch , insbesondere auf Candidaspezies untersucht . Ergebnisse und Diskussion : Die abgeloesten Membranen erwiesen sich histologisch als die obersten 2-15 Zellschichten des Epithels ohne Dysplasie oder Vesikel . Eine normale Flora wurde isoliert . Alle Patienten hatten 2-4 Wochen zuvor begonnen , die neue Zahnpaste zu gebrauchen . Nach Absetzen des Praeparats verschwanden die Veraenderungen . Moegliche Ursachen der Epitheliolyse ( Natriumlaurylsulfat Natriumtripolyphosphat ) , werden diskutiert .

[ "Fragestellung", ":", "Ein", "ungewoehnliches", "klinisches", "Bild", "von", "Epithelabloesung", "bei", "6", "Frauen", "und", "1", "Mann", "nach", "Gebrauch", "einer", "neuen", "Zahnpasta", "Odol", "-", "med", "3", "Samtweiss", "wird", "beschrieben", ".", "Material", "und", "Methoden", ":", "7", "Patienten", "im", "Alter", "zwischen", "31", "und", "72", "Jahren", "litten", "an", "einer", "allgemeinen", "Abloesung", "des", "Epithels", "der", "oralen", "Schleimhaut", ".", "In", "allen", "Bereichen", "der", "Mundhoehle", "einschliesslich", "der", "Gingiva", "propria", "wurde", "eine", "leukoedemartige", "Schicht", "gefunden", ",", "die", "sich", "spontan", "abloeste", "oder", "in", "Membranen", "von", "1", "cm2", "leicht", "mit", "der", "Pinzette", "abgeloest", "werden", "konnte", ".", "Es", "traten", "keine", "Blutungen", ",", "jedoch", "in", "2", "Faellen", "schmerzhafte", "Erosionen", "auf", ".", "Epithelproben", "wurden", "histologisch", "und", "mikrobiologisch", ",", "insbesondere", "auf", "Candidaspezies", "untersucht", ".", "Ergebnisse", "und", "Diskussion", ":", "Die", "abgeloesten", "Membranen", "erwiesen", "sich", "histologisch", "als", "die", "obersten", "2", "-", "15", "Zellschichten", "des", "Epithels", "ohne", "Dysplasie", "oder", "Vesikel", ".", "Eine", "normale", "Flora", "wurde", "isoliert", ".", "Alle", "Patienten", "hatten", "2", "-", "4", "Wochen", "zuvor", "begonnen", ",", "die", "neue", "Zahnpaste", "zu", "gebrauchen", ".", "Nach", "Absetzen", "des", "Praeparats", "verschwanden", "die", "Veraenderungen", ".", "Moegliche", "Ursachen", "der", "Epitheliolyse", "(", "Natriumlaurylsulfat", "Natriumtripolyphosphat", ")", ",", "werden", "diskutiert", "." ]

[ "umlsterm" ]

p27KIP1 is a protein, D - type cyclins is a protein-family, CDK4 is a protein, cyclin E is a protein-family, CDK2 is a protein, p27KIP1 is a protein, cyclin D - CDK4 is a protein-complex, cyclin E - CDK2 is a protein-complex

1.0alpha7.train.157_task0

Sentence: Second, it is now believed that p27KIP1 interacts mostly with D-type cyclins and CDK4 and more weakly with cyclin E and CDK2, and that binding of p27KIP1 to cyclin D-CDK4 would allow the activation of cyclin E-CDK2 complexes at the G1-S transition (54, 55, 56). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: protein-family, protein, protein-complex

[ "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "B-protein-family", "I-protein-family", "I-protein-family", "I-protein-family", "O", "B-protein", "O", "O", "O", "O", "B-protein-family", "I-protein-family", "O", "B-protein", "O", "O", "O", "O", "O", "B-protein", "O", "B-protein-complex", "I-protein-complex", "I-protein-complex", "I-protein-complex", "O", "O", "O", "O", "O", "B-protein-complex", "I-protein-complex", "I-protein-complex", "I-protein-complex", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Second, it is now believed that p27KIP1 interacts mostly with D-type cyclins and CDK4 and more weakly with cyclin E and CDK2, and that binding of p27KIP1 to cyclin D-CDK4 would allow the activation of cyclin E-CDK2 complexes at the G1-S transition (54, 55, 56).

[ "Second", ",", "it", "is", "now", "believed", "that", "p27KIP1", "interacts", "mostly", "with", "D", "-", "type", "cyclins", "and", "CDK4", "and", "more", "weakly", "with", "cyclin", "E", "and", "CDK2", ",", "and", "that", "binding", "of", "p27KIP1", "to", "cyclin", "D", "-", "CDK4", "would", "allow", "the", "activation", "of", "cyclin", "E", "-", "CDK2", "complexes", "at", "the", "G1-S", "transition", "(", "54", ",", "55", ",", "56", ")", "." ]

[ "protein-family", "protein-complex", "protein" ]

p27KIP1 is a protein, D - type cyclins is a protein-family, CDK4 is a protein, cyclin E is a protein-family, CDK2 is a protein, p27KIP1 is a protein, cyclin D - CDK4 is a protein-complex, cyclin E - CDK2 is a protein-complex

1.0alpha7.train.157_task1

Sentence: Second, it is now believed that p27KIP1 interacts mostly with D-type cyclins and CDK4 and more weakly with cyclin E and CDK2, and that binding of p27KIP1 to cyclin D-CDK4 would allow the activation of cyclin E-CDK2 complexes at the G1-S transition (54, 55, 56). Instructions: please typing these entity words according to sentence: p27KIP1, D - type cyclins, CDK4, cyclin E, CDK2, p27KIP1, cyclin D - CDK4, cyclin E - CDK2 Options: protein-family, protein, protein-complex

[ "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "B-protein-family", "I-protein-family", "I-protein-family", "I-protein-family", "O", "B-protein", "O", "O", "O", "O", "B-protein-family", "I-protein-family", "O", "B-protein", "O", "O", "O", "O", "O", "B-protein", "O", "B-protein-complex", "I-protein-complex", "I-protein-complex", "I-protein-complex", "O", "O", "O", "O", "O", "B-protein-complex", "I-protein-complex", "I-protein-complex", "I-protein-complex", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Second, it is now believed that p27KIP1 interacts mostly with D-type cyclins and CDK4 and more weakly with cyclin E and CDK2, and that binding of p27KIP1 to cyclin D-CDK4 would allow the activation of cyclin E-CDK2 complexes at the G1-S transition (54, 55, 56).

[ "Second", ",", "it", "is", "now", "believed", "that", "p27KIP1", "interacts", "mostly", "with", "D", "-", "type", "cyclins", "and", "CDK4", "and", "more", "weakly", "with", "cyclin", "E", "and", "CDK2", ",", "and", "that", "binding", "of", "p27KIP1", "to", "cyclin", "D", "-", "CDK4", "would", "allow", "the", "activation", "of", "cyclin", "E", "-", "CDK2", "complexes", "at", "the", "G1-S", "transition", "(", "54", ",", "55", ",", "56", ")", "." ]

[ "protein-family", "protein-complex", "protein" ]

p27KIP1, D - type cyclins, CDK4, cyclin E, CDK2, p27KIP1, cyclin D - CDK4, cyclin E - CDK2

1.0alpha7.train.157_task2

Sentence: Second, it is now believed that p27KIP1 interacts mostly with D-type cyclins and CDK4 and more weakly with cyclin E and CDK2, and that binding of p27KIP1 to cyclin D-CDK4 would allow the activation of cyclin E-CDK2 complexes at the G1-S transition (54, 55, 56). Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "B-protein-family", "I-protein-family", "I-protein-family", "I-protein-family", "O", "B-protein", "O", "O", "O", "O", "B-protein-family", "I-protein-family", "O", "B-protein", "O", "O", "O", "O", "O", "B-protein", "O", "B-protein-complex", "I-protein-complex", "I-protein-complex", "I-protein-complex", "O", "O", "O", "O", "O", "B-protein-complex", "I-protein-complex", "I-protein-complex", "I-protein-complex", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Second, it is now believed that p27KIP1 interacts mostly with D-type cyclins and CDK4 and more weakly with cyclin E and CDK2, and that binding of p27KIP1 to cyclin D-CDK4 would allow the activation of cyclin E-CDK2 complexes at the G1-S transition (54, 55, 56).

[ "Second", ",", "it", "is", "now", "believed", "that", "p27KIP1", "interacts", "mostly", "with", "D", "-", "type", "cyclins", "and", "CDK4", "and", "more", "weakly", "with", "cyclin", "E", "and", "CDK2", ",", "and", "that", "binding", "of", "p27KIP1", "to", "cyclin", "D", "-", "CDK4", "would", "allow", "the", "activation", "of", "cyclin", "E", "-", "CDK2", "complexes", "at", "the", "G1-S", "transition", "(", "54", ",", "55", ",", "56", ")", "." ]

[ "protein-family", "protein-complex", "protein" ]

Gelenke is an umlsterm, Nervenfasern is an umlsterm, Nozizeptoren is an umlsterm, gewebeschaedigender is an umlsterm, Noxen is an umlsterm, Erregung is an umlsterm, Nozizeptoren is an umlsterm, Menschen is an umlsterm, Schmerzen is an umlsterm, Nozizeptoren is an umlsterm, Gewebe is an umlsterm, Nozizeptoren is an umlsterm, Schmerzen is an umlsterm, Nozizeptoren is an umlsterm, Entzuendungsmediatoren is an umlsterm, Bradykinin is an umlsterm, Prostaglandine is an umlsterm, Nozizeptoren is an umlsterm, Substanz P is an umlsterm, Gewebe is an umlsterm, neurogene Entzuendung is an umlsterm, Nozizeptoren is an umlsterm, Gewebeveraenderungen is an umlsterm

ManuelleMedizin.70350077.ger.abstr_task0

Sentence: Gelenke werden von nozizeptiven Nervenfasern ( Nozizeptoren ) innerviert , die ausschliesslich bei Einwirkung gewebeschaedigender Reize ( Noxen ) aktiviert werden . In der Regel fuehrt die Erregung von Nozizeptoren beim wachen Menschen zu Schmerzen . Besonders bei entzuendlichen Vorgaengen werden die sensorischen Endigungen vieler Nozizeptoren im Gewebe sensibilisiert . Unter diesen Bedingungen genuegen bereits normalerweise nichtnoxische bzw. nichtschmerzhafte Reize , um die Nozizeptoren zu aktivieren und Schmerzen auszuloesen . Fuer die Sensibilisierung von Nozizeptoren ist die Wirkung von Entzuendungsmediatoren wie Bradykinin und Prostaglandine wichtig . Neben ihrer sensorischen Funktion besitzen viele Nozizeptoren auch eine efferente Funktion . Durch die Freisetzung von Neuropeptiden wie Substanz P und Calcitonin-gene-related-Peptide im Gewebe bewirken sie eine neurogene Entzuendung . Diese efferente Wirkung der Nozizeptoren traegt zur Entstehung entzuendlicher Gewebeveraenderungen bei . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]

Gelenke werden von nozizeptiven Nervenfasern ( Nozizeptoren ) innerviert , die ausschliesslich bei Einwirkung gewebeschaedigender Reize ( Noxen ) aktiviert werden . In der Regel fuehrt die Erregung von Nozizeptoren beim wachen Menschen zu Schmerzen . Besonders bei entzuendlichen Vorgaengen werden die sensorischen Endigungen vieler Nozizeptoren im Gewebe sensibilisiert . Unter diesen Bedingungen genuegen bereits normalerweise nichtnoxische bzw. nichtschmerzhafte Reize , um die Nozizeptoren zu aktivieren und Schmerzen auszuloesen . Fuer die Sensibilisierung von Nozizeptoren ist die Wirkung von Entzuendungsmediatoren wie Bradykinin und Prostaglandine wichtig . Neben ihrer sensorischen Funktion besitzen viele Nozizeptoren auch eine efferente Funktion . Durch die Freisetzung von Neuropeptiden wie Substanz P und Calcitonin-gene-related-Peptide im Gewebe bewirken sie eine neurogene Entzuendung . Diese efferente Wirkung der Nozizeptoren traegt zur Entstehung entzuendlicher Gewebeveraenderungen bei .

[ "Gelenke", "werden", "von", "nozizeptiven", "Nervenfasern", "(", "Nozizeptoren", ")", "innerviert", ",", "die", "ausschliesslich", "bei", "Einwirkung", "gewebeschaedigender", "Reize", "(", "Noxen", ")", "aktiviert", "werden", ".", "In", "der", "Regel", "fuehrt", "die", "Erregung", "von", "Nozizeptoren", "beim", "wachen", "Menschen", "zu", "Schmerzen", ".", "Besonders", "bei", "entzuendlichen", "Vorgaengen", "werden", "die", "sensorischen", "Endigungen", "vieler", "Nozizeptoren", "im", "Gewebe", "sensibilisiert", ".", "Unter", "diesen", "Bedingungen", "genuegen", "bereits", "normalerweise", "nichtnoxische", "bzw", ".", "nichtschmerzhafte", "Reize", ",", "um", "die", "Nozizeptoren", "zu", "aktivieren", "und", "Schmerzen", "auszuloesen", ".", "Fuer", "die", "Sensibilisierung", "von", "Nozizeptoren", "ist", "die", "Wirkung", "von", "Entzuendungsmediatoren", "wie", "Bradykinin", "und", "Prostaglandine", "wichtig", ".", "Neben", "ihrer", "sensorischen", "Funktion", "besitzen", "viele", "Nozizeptoren", "auch", "eine", "efferente", "Funktion", ".", "Durch", "die", "Freisetzung", "von", "Neuropeptiden", "wie", "Substanz", "P", "und", "Calcitonin", "-", "gene", "-", "related", "-", "Peptide", "im", "Gewebe", "bewirken", "sie", "eine", "neurogene", "Entzuendung", ".", "Diese", "efferente", "Wirkung", "der", "Nozizeptoren", "traegt", "zur", "Entstehung", "entzuendlicher", "Gewebeveraenderungen", "bei", "." ]

[ "umlsterm" ]

Gelenke is an umlsterm, Nervenfasern is an umlsterm, Nozizeptoren is an umlsterm, gewebeschaedigender is an umlsterm, Noxen is an umlsterm, Erregung is an umlsterm, Nozizeptoren is an umlsterm, Menschen is an umlsterm, Schmerzen is an umlsterm, Nozizeptoren is an umlsterm, Gewebe is an umlsterm, Nozizeptoren is an umlsterm, Schmerzen is an umlsterm, Nozizeptoren is an umlsterm, Entzuendungsmediatoren is an umlsterm, Bradykinin is an umlsterm, Prostaglandine is an umlsterm, Nozizeptoren is an umlsterm, Substanz P is an umlsterm, Gewebe is an umlsterm, neurogene Entzuendung is an umlsterm, Nozizeptoren is an umlsterm, Gewebeveraenderungen is an umlsterm

ManuelleMedizin.70350077.ger.abstr_task1

Sentence: Gelenke werden von nozizeptiven Nervenfasern ( Nozizeptoren ) innerviert , die ausschliesslich bei Einwirkung gewebeschaedigender Reize ( Noxen ) aktiviert werden . In der Regel fuehrt die Erregung von Nozizeptoren beim wachen Menschen zu Schmerzen . Besonders bei entzuendlichen Vorgaengen werden die sensorischen Endigungen vieler Nozizeptoren im Gewebe sensibilisiert . Unter diesen Bedingungen genuegen bereits normalerweise nichtnoxische bzw. nichtschmerzhafte Reize , um die Nozizeptoren zu aktivieren und Schmerzen auszuloesen . Fuer die Sensibilisierung von Nozizeptoren ist die Wirkung von Entzuendungsmediatoren wie Bradykinin und Prostaglandine wichtig . Neben ihrer sensorischen Funktion besitzen viele Nozizeptoren auch eine efferente Funktion . Durch die Freisetzung von Neuropeptiden wie Substanz P und Calcitonin-gene-related-Peptide im Gewebe bewirken sie eine neurogene Entzuendung . Diese efferente Wirkung der Nozizeptoren traegt zur Entstehung entzuendlicher Gewebeveraenderungen bei . Instructions: please typing these entity words according to sentence: Gelenke, Nervenfasern, Nozizeptoren, gewebeschaedigender, Noxen, Erregung, Nozizeptoren, Menschen, Schmerzen, Nozizeptoren, Gewebe, Nozizeptoren, Schmerzen, Nozizeptoren, Entzuendungsmediatoren, Bradykinin, Prostaglandine, Nozizeptoren, Substanz P, Gewebe, neurogene Entzuendung, Nozizeptoren, Gewebeveraenderungen Options: umlsterm

[ "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]

Gelenke werden von nozizeptiven Nervenfasern ( Nozizeptoren ) innerviert , die ausschliesslich bei Einwirkung gewebeschaedigender Reize ( Noxen ) aktiviert werden . In der Regel fuehrt die Erregung von Nozizeptoren beim wachen Menschen zu Schmerzen . Besonders bei entzuendlichen Vorgaengen werden die sensorischen Endigungen vieler Nozizeptoren im Gewebe sensibilisiert . Unter diesen Bedingungen genuegen bereits normalerweise nichtnoxische bzw. nichtschmerzhafte Reize , um die Nozizeptoren zu aktivieren und Schmerzen auszuloesen . Fuer die Sensibilisierung von Nozizeptoren ist die Wirkung von Entzuendungsmediatoren wie Bradykinin und Prostaglandine wichtig . Neben ihrer sensorischen Funktion besitzen viele Nozizeptoren auch eine efferente Funktion . Durch die Freisetzung von Neuropeptiden wie Substanz P und Calcitonin-gene-related-Peptide im Gewebe bewirken sie eine neurogene Entzuendung . Diese efferente Wirkung der Nozizeptoren traegt zur Entstehung entzuendlicher Gewebeveraenderungen bei .

[ "Gelenke", "werden", "von", "nozizeptiven", "Nervenfasern", "(", "Nozizeptoren", ")", "innerviert", ",", "die", "ausschliesslich", "bei", "Einwirkung", "gewebeschaedigender", "Reize", "(", "Noxen", ")", "aktiviert", "werden", ".", "In", "der", "Regel", "fuehrt", "die", "Erregung", "von", "Nozizeptoren", "beim", "wachen", "Menschen", "zu", "Schmerzen", ".", "Besonders", "bei", "entzuendlichen", "Vorgaengen", "werden", "die", "sensorischen", "Endigungen", "vieler", "Nozizeptoren", "im", "Gewebe", "sensibilisiert", ".", "Unter", "diesen", "Bedingungen", "genuegen", "bereits", "normalerweise", "nichtnoxische", "bzw", ".", "nichtschmerzhafte", "Reize", ",", "um", "die", "Nozizeptoren", "zu", "aktivieren", "und", "Schmerzen", "auszuloesen", ".", "Fuer", "die", "Sensibilisierung", "von", "Nozizeptoren", "ist", "die", "Wirkung", "von", "Entzuendungsmediatoren", "wie", "Bradykinin", "und", "Prostaglandine", "wichtig", ".", "Neben", "ihrer", "sensorischen", "Funktion", "besitzen", "viele", "Nozizeptoren", "auch", "eine", "efferente", "Funktion", ".", "Durch", "die", "Freisetzung", "von", "Neuropeptiden", "wie", "Substanz", "P", "und", "Calcitonin", "-", "gene", "-", "related", "-", "Peptide", "im", "Gewebe", "bewirken", "sie", "eine", "neurogene", "Entzuendung", ".", "Diese", "efferente", "Wirkung", "der", "Nozizeptoren", "traegt", "zur", "Entstehung", "entzuendlicher", "Gewebeveraenderungen", "bei", "." ]

[ "umlsterm" ]

Gelenke, Nervenfasern, Nozizeptoren, gewebeschaedigender, Noxen, Erregung, Nozizeptoren, Menschen, Schmerzen, Nozizeptoren, Gewebe, Nozizeptoren, Schmerzen, Nozizeptoren, Entzuendungsmediatoren, Bradykinin, Prostaglandine, Nozizeptoren, Substanz P, Gewebe, neurogene Entzuendung, Nozizeptoren, Gewebeveraenderungen

ManuelleMedizin.70350077.ger.abstr_task2

Sentence: Gelenke werden von nozizeptiven Nervenfasern ( Nozizeptoren ) innerviert , die ausschliesslich bei Einwirkung gewebeschaedigender Reize ( Noxen ) aktiviert werden . In der Regel fuehrt die Erregung von Nozizeptoren beim wachen Menschen zu Schmerzen . Besonders bei entzuendlichen Vorgaengen werden die sensorischen Endigungen vieler Nozizeptoren im Gewebe sensibilisiert . Unter diesen Bedingungen genuegen bereits normalerweise nichtnoxische bzw. nichtschmerzhafte Reize , um die Nozizeptoren zu aktivieren und Schmerzen auszuloesen . Fuer die Sensibilisierung von Nozizeptoren ist die Wirkung von Entzuendungsmediatoren wie Bradykinin und Prostaglandine wichtig . Neben ihrer sensorischen Funktion besitzen viele Nozizeptoren auch eine efferente Funktion . Durch die Freisetzung von Neuropeptiden wie Substanz P und Calcitonin-gene-related-Peptide im Gewebe bewirken sie eine neurogene Entzuendung . Diese efferente Wirkung der Nozizeptoren traegt zur Entstehung entzuendlicher Gewebeveraenderungen bei . Instructions: please extract entity words from the input sentence

[ "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]

Gelenke werden von nozizeptiven Nervenfasern ( Nozizeptoren ) innerviert , die ausschliesslich bei Einwirkung gewebeschaedigender Reize ( Noxen ) aktiviert werden . In der Regel fuehrt die Erregung von Nozizeptoren beim wachen Menschen zu Schmerzen . Besonders bei entzuendlichen Vorgaengen werden die sensorischen Endigungen vieler Nozizeptoren im Gewebe sensibilisiert . Unter diesen Bedingungen genuegen bereits normalerweise nichtnoxische bzw. nichtschmerzhafte Reize , um die Nozizeptoren zu aktivieren und Schmerzen auszuloesen . Fuer die Sensibilisierung von Nozizeptoren ist die Wirkung von Entzuendungsmediatoren wie Bradykinin und Prostaglandine wichtig . Neben ihrer sensorischen Funktion besitzen viele Nozizeptoren auch eine efferente Funktion . Durch die Freisetzung von Neuropeptiden wie Substanz P und Calcitonin-gene-related-Peptide im Gewebe bewirken sie eine neurogene Entzuendung . Diese efferente Wirkung der Nozizeptoren traegt zur Entstehung entzuendlicher Gewebeveraenderungen bei .

[ "Gelenke", "werden", "von", "nozizeptiven", "Nervenfasern", "(", "Nozizeptoren", ")", "innerviert", ",", "die", "ausschliesslich", "bei", "Einwirkung", "gewebeschaedigender", "Reize", "(", "Noxen", ")", "aktiviert", "werden", ".", "In", "der", "Regel", "fuehrt", "die", "Erregung", "von", "Nozizeptoren", "beim", "wachen", "Menschen", "zu", "Schmerzen", ".", "Besonders", "bei", "entzuendlichen", "Vorgaengen", "werden", "die", "sensorischen", "Endigungen", "vieler", "Nozizeptoren", "im", "Gewebe", "sensibilisiert", ".", "Unter", "diesen", "Bedingungen", "genuegen", "bereits", "normalerweise", "nichtnoxische", "bzw", ".", "nichtschmerzhafte", "Reize", ",", "um", "die", "Nozizeptoren", "zu", "aktivieren", "und", "Schmerzen", "auszuloesen", ".", "Fuer", "die", "Sensibilisierung", "von", "Nozizeptoren", "ist", "die", "Wirkung", "von", "Entzuendungsmediatoren", "wie", "Bradykinin", "und", "Prostaglandine", "wichtig", ".", "Neben", "ihrer", "sensorischen", "Funktion", "besitzen", "viele", "Nozizeptoren", "auch", "eine", "efferente", "Funktion", ".", "Durch", "die", "Freisetzung", "von", "Neuropeptiden", "wie", "Substanz", "P", "und", "Calcitonin", "-", "gene", "-", "related", "-", "Peptide", "im", "Gewebe", "bewirken", "sie", "eine", "neurogene", "Entzuendung", ".", "Diese", "efferente", "Wirkung", "der", "Nozizeptoren", "traegt", "zur", "Entstehung", "entzuendlicher", "Gewebeveraenderungen", "bei", "." ]

[ "umlsterm" ]

implantation is an umlsterm, inguinal hernia is an umlsterm, surgery is an umlsterm, man is an umlsterm, syndrome is an umlsterm, pain is an umlsterm, TAPP is an umlsterm, procedure is an umlsterm, inguinal hernia is an umlsterm, reoperation is an umlsterm, removement is an umlsterm, clips is an umlsterm, nerve is an umlsterm, operation is an umlsterm, Prolene is an umlsterm, inguinal hernia is an umlsterm, surgery is an umlsterm

DerChirurg.70681297.eng.abstr_task0

Sentence: The implantation of a mesh is an essential step in laparoscopic inguinal hernia surgery . We present the case of a 22-year-old man who developed an unspecific and refractory syndrome of inguinal pain after a TAPP procedure for a primary inguinal hernia . Repeated reoperation for removement of clips and nerve transection were unsuccessful . By a transinguinal approach , 18 months after the first operation we removed a preperitoneal Prolene mesh which had shrunk and folded to 30 % of its original size . The problem of biocompatibility of meshes currently used in inguinal hernia surgery is discussed . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O" ]

The implantation of a mesh is an essential step in laparoscopic inguinal hernia surgery . We present the case of a 22-year-old man who developed an unspecific and refractory syndrome of inguinal pain after a TAPP procedure for a primary inguinal hernia . Repeated reoperation for removement of clips and nerve transection were unsuccessful . By a transinguinal approach , 18 months after the first operation we removed a preperitoneal Prolene mesh which had shrunk and folded to 30 % of its original size . The problem of biocompatibility of meshes currently used in inguinal hernia surgery is discussed .

[ "The", "implantation", "of", "a", "mesh", "is", "an", "essential", "step", "in", "laparoscopic", "inguinal", "hernia", "surgery", ".", "We", "present", "the", "case", "of", "a", "22-year", "-", "old", "man", "who", "developed", "an", "unspecific", "and", "refractory", "syndrome", "of", "inguinal", "pain", "after", "a", "TAPP", "procedure", "for", "a", "primary", "inguinal", "hernia", ".", "Repeated", "reoperation", "for", "removement", "of", "clips", "and", "nerve", "transection", "were", "unsuccessful", ".", "By", "a", "transinguinal", "approach", ",", "18", "months", "after", "the", "first", "operation", "we", "removed", "a", "preperitoneal", "Prolene", "mesh", "which", "had", "shrunk", "and", "folded", "to", "30", "%", "of", "its", "original", "size", ".", "The", "problem", "of", "biocompatibility", "of", "meshes", "currently", "used", "in", "inguinal", "hernia", "surgery", "is", "discussed", "." ]

[ "umlsterm" ]

implantation is an umlsterm, inguinal hernia is an umlsterm, surgery is an umlsterm, man is an umlsterm, syndrome is an umlsterm, pain is an umlsterm, TAPP is an umlsterm, procedure is an umlsterm, inguinal hernia is an umlsterm, reoperation is an umlsterm, removement is an umlsterm, clips is an umlsterm, nerve is an umlsterm, operation is an umlsterm, Prolene is an umlsterm, inguinal hernia is an umlsterm, surgery is an umlsterm

DerChirurg.70681297.eng.abstr_task1

Sentence: The implantation of a mesh is an essential step in laparoscopic inguinal hernia surgery . We present the case of a 22-year-old man who developed an unspecific and refractory syndrome of inguinal pain after a TAPP procedure for a primary inguinal hernia . Repeated reoperation for removement of clips and nerve transection were unsuccessful . By a transinguinal approach , 18 months after the first operation we removed a preperitoneal Prolene mesh which had shrunk and folded to 30 % of its original size . The problem of biocompatibility of meshes currently used in inguinal hernia surgery is discussed . Instructions: please typing these entity words according to sentence: implantation, inguinal hernia, surgery, man, syndrome, pain, TAPP, procedure, inguinal hernia, reoperation, removement, clips, nerve, operation, Prolene, inguinal hernia, surgery Options: umlsterm

[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O" ]

The implantation of a mesh is an essential step in laparoscopic inguinal hernia surgery . We present the case of a 22-year-old man who developed an unspecific and refractory syndrome of inguinal pain after a TAPP procedure for a primary inguinal hernia . Repeated reoperation for removement of clips and nerve transection were unsuccessful . By a transinguinal approach , 18 months after the first operation we removed a preperitoneal Prolene mesh which had shrunk and folded to 30 % of its original size . The problem of biocompatibility of meshes currently used in inguinal hernia surgery is discussed .

[ "The", "implantation", "of", "a", "mesh", "is", "an", "essential", "step", "in", "laparoscopic", "inguinal", "hernia", "surgery", ".", "We", "present", "the", "case", "of", "a", "22-year", "-", "old", "man", "who", "developed", "an", "unspecific", "and", "refractory", "syndrome", "of", "inguinal", "pain", "after", "a", "TAPP", "procedure", "for", "a", "primary", "inguinal", "hernia", ".", "Repeated", "reoperation", "for", "removement", "of", "clips", "and", "nerve", "transection", "were", "unsuccessful", ".", "By", "a", "transinguinal", "approach", ",", "18", "months", "after", "the", "first", "operation", "we", "removed", "a", "preperitoneal", "Prolene", "mesh", "which", "had", "shrunk", "and", "folded", "to", "30", "%", "of", "its", "original", "size", ".", "The", "problem", "of", "biocompatibility", "of", "meshes", "currently", "used", "in", "inguinal", "hernia", "surgery", "is", "discussed", "." ]

[ "umlsterm" ]

implantation, inguinal hernia, surgery, man, syndrome, pain, TAPP, procedure, inguinal hernia, reoperation, removement, clips, nerve, operation, Prolene, inguinal hernia, surgery

DerChirurg.70681297.eng.abstr_task2

Sentence: The implantation of a mesh is an essential step in laparoscopic inguinal hernia surgery . We present the case of a 22-year-old man who developed an unspecific and refractory syndrome of inguinal pain after a TAPP procedure for a primary inguinal hernia . Repeated reoperation for removement of clips and nerve transection were unsuccessful . By a transinguinal approach , 18 months after the first operation we removed a preperitoneal Prolene mesh which had shrunk and folded to 30 % of its original size . The problem of biocompatibility of meshes currently used in inguinal hernia surgery is discussed . Instructions: please extract entity words from the input sentence

[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O" ]

The implantation of a mesh is an essential step in laparoscopic inguinal hernia surgery . We present the case of a 22-year-old man who developed an unspecific and refractory syndrome of inguinal pain after a TAPP procedure for a primary inguinal hernia . Repeated reoperation for removement of clips and nerve transection were unsuccessful . By a transinguinal approach , 18 months after the first operation we removed a preperitoneal Prolene mesh which had shrunk and folded to 30 % of its original size . The problem of biocompatibility of meshes currently used in inguinal hernia surgery is discussed .

[ "The", "implantation", "of", "a", "mesh", "is", "an", "essential", "step", "in", "laparoscopic", "inguinal", "hernia", "surgery", ".", "We", "present", "the", "case", "of", "a", "22-year", "-", "old", "man", "who", "developed", "an", "unspecific", "and", "refractory", "syndrome", "of", "inguinal", "pain", "after", "a", "TAPP", "procedure", "for", "a", "primary", "inguinal", "hernia", ".", "Repeated", "reoperation", "for", "removement", "of", "clips", "and", "nerve", "transection", "were", "unsuccessful", ".", "By", "a", "transinguinal", "approach", ",", "18", "months", "after", "the", "first", "operation", "we", "removed", "a", "preperitoneal", "Prolene", "mesh", "which", "had", "shrunk", "and", "folded", "to", "30", "%", "of", "its", "original", "size", ".", "The", "problem", "of", "biocompatibility", "of", "meshes", "currently", "used", "in", "inguinal", "hernia", "surgery", "is", "discussed", "." ]

[ "umlsterm" ]

Therapiestrategien is an umlsterm, Pankreaskarzinom is an umlsterm, Karzinome is an umlsterm, Selbst is an umlsterm, Karzinome is an umlsterm, Radiotherapie is an umlsterm, Analyse is an umlsterm, Morbiditaet is an umlsterm, Radiotherapie is an umlsterm, Morbiditaet is an umlsterm, Behandlung is an umlsterm, Tumorkontrolle is an umlsterm, Schmerzbesserung is an umlsterm, Patienten is an umlsterm, Gesamtprognose is an umlsterm, Karzinomen is an umlsterm, Risiko is an umlsterm, Gastrointestinalblutung is an umlsterm

DerRadiologe.60360441.ger.abstr_task0

Sentence: Therapiestrategien beim Pankreaskarzinom werden bestimmt durch den hohen Anteil primaer nicht resektabler Karzinome , der hohen relativen Strahlenresistenz und der hohen Fernmetastasierungsrate . Selbst kurativ resezierte Karzinome erfordern durch ihre hohe lokale Tumorzellpersistenz eine lokal effektive adjuvante Behandlungsmassnahme . Die Effektivitaet einer Radiotherapie ist dosisabhaengig . Aus der Analyse publizierter Daten wird eine Dosis von > 50 Gy , welche bei der alleinigen perkutanen Bestrahlung mit einer hohen Morbiditaet verbunden ist , empfohlen . Mit der intraoperativen Radiotherapie ist eine lokal begrenzte Dosiseskalation ohne erhoehte perioperative Morbiditaet moeglich . Sowohl in der adjuvanten als auch in der primaeren Behandlung kann die lokale Tumorkontrolle deutlich verbessert werden ( 70-90 % ) . Unter palliativen Gesichtspunkten wird eine rasche und langandauernde Schmerzbesserung bei ueber 60 % der Patienten erreicht . Die Gesamtprognose wird jedoch durch die unveraendert hohe Fernmetastasierungsrate sowohl nach kurativer Resektion als auch bei primaerer Inoperabilitaet relativiert . Die weitere Dosiseskalation ist bei inoperablen Karzinomen durch das hohe Risiko ( 20-30 % ) einer Gastrointestinalblutung limitiert . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]

Therapiestrategien beim Pankreaskarzinom werden bestimmt durch den hohen Anteil primaer nicht resektabler Karzinome , der hohen relativen Strahlenresistenz und der hohen Fernmetastasierungsrate . Selbst kurativ resezierte Karzinome erfordern durch ihre hohe lokale Tumorzellpersistenz eine lokal effektive adjuvante Behandlungsmassnahme . Die Effektivitaet einer Radiotherapie ist dosisabhaengig . Aus der Analyse publizierter Daten wird eine Dosis von > 50 Gy , welche bei der alleinigen perkutanen Bestrahlung mit einer hohen Morbiditaet verbunden ist , empfohlen . Mit der intraoperativen Radiotherapie ist eine lokal begrenzte Dosiseskalation ohne erhoehte perioperative Morbiditaet moeglich . Sowohl in der adjuvanten als auch in der primaeren Behandlung kann die lokale Tumorkontrolle deutlich verbessert werden ( 70-90 % ) . Unter palliativen Gesichtspunkten wird eine rasche und langandauernde Schmerzbesserung bei ueber 60 % der Patienten erreicht . Die Gesamtprognose wird jedoch durch die unveraendert hohe Fernmetastasierungsrate sowohl nach kurativer Resektion als auch bei primaerer Inoperabilitaet relativiert . Die weitere Dosiseskalation ist bei inoperablen Karzinomen durch das hohe Risiko ( 20-30 % ) einer Gastrointestinalblutung limitiert .

[ "Therapiestrategien", "beim", "Pankreaskarzinom", "werden", "bestimmt", "durch", "den", "hohen", "Anteil", "primaer", "nicht", "resektabler", "Karzinome", ",", "der", "hohen", "relativen", "Strahlenresistenz", "und", "der", "hohen", "Fernmetastasierungsrate", ".", "Selbst", "kurativ", "resezierte", "Karzinome", "erfordern", "durch", "ihre", "hohe", "lokale", "Tumorzellpersistenz", "eine", "lokal", "effektive", "adjuvante", "Behandlungsmassnahme", ".", "Die", "Effektivitaet", "einer", "Radiotherapie", "ist", "dosisabhaengig", ".", "Aus", "der", "Analyse", "publizierter", "Daten", "wird", "eine", "Dosis", "von", ">", "50", "Gy", ",", "welche", "bei", "der", "alleinigen", "perkutanen", "Bestrahlung", "mit", "einer", "hohen", "Morbiditaet", "verbunden", "ist", ",", "empfohlen", ".", "Mit", "der", "intraoperativen", "Radiotherapie", "ist", "eine", "lokal", "begrenzte", "Dosiseskalation", "ohne", "erhoehte", "perioperative", "Morbiditaet", "moeglich", ".", "Sowohl", "in", "der", "adjuvanten", "als", "auch", "in", "der", "primaeren", "Behandlung", "kann", "die", "lokale", "Tumorkontrolle", "deutlich", "verbessert", "werden", "(", "70", "-", "90", "%", ")", ".", "Unter", "palliativen", "Gesichtspunkten", "wird", "eine", "rasche", "und", "langandauernde", "Schmerzbesserung", "bei", "ueber", "60", "%", "der", "Patienten", "erreicht", ".", "Die", "Gesamtprognose", "wird", "jedoch", "durch", "die", "unveraendert", "hohe", "Fernmetastasierungsrate", "sowohl", "nach", "kurativer", "Resektion", "als", "auch", "bei", "primaerer", "Inoperabilitaet", "relativiert", ".", "Die", "weitere", "Dosiseskalation", "ist", "bei", "inoperablen", "Karzinomen", "durch", "das", "hohe", "Risiko", "(", "20", "-", "30", "%", ")", "einer", "Gastrointestinalblutung", "limitiert", "." ]

[ "umlsterm" ]

Therapiestrategien is an umlsterm, Pankreaskarzinom is an umlsterm, Karzinome is an umlsterm, Selbst is an umlsterm, Karzinome is an umlsterm, Radiotherapie is an umlsterm, Analyse is an umlsterm, Morbiditaet is an umlsterm, Radiotherapie is an umlsterm, Morbiditaet is an umlsterm, Behandlung is an umlsterm, Tumorkontrolle is an umlsterm, Schmerzbesserung is an umlsterm, Patienten is an umlsterm, Gesamtprognose is an umlsterm, Karzinomen is an umlsterm, Risiko is an umlsterm, Gastrointestinalblutung is an umlsterm

DerRadiologe.60360441.ger.abstr_task1

Sentence: Therapiestrategien beim Pankreaskarzinom werden bestimmt durch den hohen Anteil primaer nicht resektabler Karzinome , der hohen relativen Strahlenresistenz und der hohen Fernmetastasierungsrate . Selbst kurativ resezierte Karzinome erfordern durch ihre hohe lokale Tumorzellpersistenz eine lokal effektive adjuvante Behandlungsmassnahme . Die Effektivitaet einer Radiotherapie ist dosisabhaengig . Aus der Analyse publizierter Daten wird eine Dosis von > 50 Gy , welche bei der alleinigen perkutanen Bestrahlung mit einer hohen Morbiditaet verbunden ist , empfohlen . Mit der intraoperativen Radiotherapie ist eine lokal begrenzte Dosiseskalation ohne erhoehte perioperative Morbiditaet moeglich . Sowohl in der adjuvanten als auch in der primaeren Behandlung kann die lokale Tumorkontrolle deutlich verbessert werden ( 70-90 % ) . Unter palliativen Gesichtspunkten wird eine rasche und langandauernde Schmerzbesserung bei ueber 60 % der Patienten erreicht . Die Gesamtprognose wird jedoch durch die unveraendert hohe Fernmetastasierungsrate sowohl nach kurativer Resektion als auch bei primaerer Inoperabilitaet relativiert . Die weitere Dosiseskalation ist bei inoperablen Karzinomen durch das hohe Risiko ( 20-30 % ) einer Gastrointestinalblutung limitiert . Instructions: please typing these entity words according to sentence: Therapiestrategien, Pankreaskarzinom, Karzinome, Selbst, Karzinome, Radiotherapie, Analyse, Morbiditaet, Radiotherapie, Morbiditaet, Behandlung, Tumorkontrolle, Schmerzbesserung, Patienten, Gesamtprognose, Karzinomen, Risiko, Gastrointestinalblutung Options: umlsterm

[ "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]

Therapiestrategien beim Pankreaskarzinom werden bestimmt durch den hohen Anteil primaer nicht resektabler Karzinome , der hohen relativen Strahlenresistenz und der hohen Fernmetastasierungsrate . Selbst kurativ resezierte Karzinome erfordern durch ihre hohe lokale Tumorzellpersistenz eine lokal effektive adjuvante Behandlungsmassnahme . Die Effektivitaet einer Radiotherapie ist dosisabhaengig . Aus der Analyse publizierter Daten wird eine Dosis von > 50 Gy , welche bei der alleinigen perkutanen Bestrahlung mit einer hohen Morbiditaet verbunden ist , empfohlen . Mit der intraoperativen Radiotherapie ist eine lokal begrenzte Dosiseskalation ohne erhoehte perioperative Morbiditaet moeglich . Sowohl in der adjuvanten als auch in der primaeren Behandlung kann die lokale Tumorkontrolle deutlich verbessert werden ( 70-90 % ) . Unter palliativen Gesichtspunkten wird eine rasche und langandauernde Schmerzbesserung bei ueber 60 % der Patienten erreicht . Die Gesamtprognose wird jedoch durch die unveraendert hohe Fernmetastasierungsrate sowohl nach kurativer Resektion als auch bei primaerer Inoperabilitaet relativiert . Die weitere Dosiseskalation ist bei inoperablen Karzinomen durch das hohe Risiko ( 20-30 % ) einer Gastrointestinalblutung limitiert .

[ "Therapiestrategien", "beim", "Pankreaskarzinom", "werden", "bestimmt", "durch", "den", "hohen", "Anteil", "primaer", "nicht", "resektabler", "Karzinome", ",", "der", "hohen", "relativen", "Strahlenresistenz", "und", "der", "hohen", "Fernmetastasierungsrate", ".", "Selbst", "kurativ", "resezierte", "Karzinome", "erfordern", "durch", "ihre", "hohe", "lokale", "Tumorzellpersistenz", "eine", "lokal", "effektive", "adjuvante", "Behandlungsmassnahme", ".", "Die", "Effektivitaet", "einer", "Radiotherapie", "ist", "dosisabhaengig", ".", "Aus", "der", "Analyse", "publizierter", "Daten", "wird", "eine", "Dosis", "von", ">", "50", "Gy", ",", "welche", "bei", "der", "alleinigen", "perkutanen", "Bestrahlung", "mit", "einer", "hohen", "Morbiditaet", "verbunden", "ist", ",", "empfohlen", ".", "Mit", "der", "intraoperativen", "Radiotherapie", "ist", "eine", "lokal", "begrenzte", "Dosiseskalation", "ohne", "erhoehte", "perioperative", "Morbiditaet", "moeglich", ".", "Sowohl", "in", "der", "adjuvanten", "als", "auch", "in", "der", "primaeren", "Behandlung", "kann", "die", "lokale", "Tumorkontrolle", "deutlich", "verbessert", "werden", "(", "70", "-", "90", "%", ")", ".", "Unter", "palliativen", "Gesichtspunkten", "wird", "eine", "rasche", "und", "langandauernde", "Schmerzbesserung", "bei", "ueber", "60", "%", "der", "Patienten", "erreicht", ".", "Die", "Gesamtprognose", "wird", "jedoch", "durch", "die", "unveraendert", "hohe", "Fernmetastasierungsrate", "sowohl", "nach", "kurativer", "Resektion", "als", "auch", "bei", "primaerer", "Inoperabilitaet", "relativiert", ".", "Die", "weitere", "Dosiseskalation", "ist", "bei", "inoperablen", "Karzinomen", "durch", "das", "hohe", "Risiko", "(", "20", "-", "30", "%", ")", "einer", "Gastrointestinalblutung", "limitiert", "." ]

[ "umlsterm" ]

Therapiestrategien, Pankreaskarzinom, Karzinome, Selbst, Karzinome, Radiotherapie, Analyse, Morbiditaet, Radiotherapie, Morbiditaet, Behandlung, Tumorkontrolle, Schmerzbesserung, Patienten, Gesamtprognose, Karzinomen, Risiko, Gastrointestinalblutung

DerRadiologe.60360441.ger.abstr_task2

Sentence: Therapiestrategien beim Pankreaskarzinom werden bestimmt durch den hohen Anteil primaer nicht resektabler Karzinome , der hohen relativen Strahlenresistenz und der hohen Fernmetastasierungsrate . Selbst kurativ resezierte Karzinome erfordern durch ihre hohe lokale Tumorzellpersistenz eine lokal effektive adjuvante Behandlungsmassnahme . Die Effektivitaet einer Radiotherapie ist dosisabhaengig . Aus der Analyse publizierter Daten wird eine Dosis von > 50 Gy , welche bei der alleinigen perkutanen Bestrahlung mit einer hohen Morbiditaet verbunden ist , empfohlen . Mit der intraoperativen Radiotherapie ist eine lokal begrenzte Dosiseskalation ohne erhoehte perioperative Morbiditaet moeglich . Sowohl in der adjuvanten als auch in der primaeren Behandlung kann die lokale Tumorkontrolle deutlich verbessert werden ( 70-90 % ) . Unter palliativen Gesichtspunkten wird eine rasche und langandauernde Schmerzbesserung bei ueber 60 % der Patienten erreicht . Die Gesamtprognose wird jedoch durch die unveraendert hohe Fernmetastasierungsrate sowohl nach kurativer Resektion als auch bei primaerer Inoperabilitaet relativiert . Die weitere Dosiseskalation ist bei inoperablen Karzinomen durch das hohe Risiko ( 20-30 % ) einer Gastrointestinalblutung limitiert . Instructions: please extract entity words from the input sentence

[ "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]

Therapiestrategien beim Pankreaskarzinom werden bestimmt durch den hohen Anteil primaer nicht resektabler Karzinome , der hohen relativen Strahlenresistenz und der hohen Fernmetastasierungsrate . Selbst kurativ resezierte Karzinome erfordern durch ihre hohe lokale Tumorzellpersistenz eine lokal effektive adjuvante Behandlungsmassnahme . Die Effektivitaet einer Radiotherapie ist dosisabhaengig . Aus der Analyse publizierter Daten wird eine Dosis von > 50 Gy , welche bei der alleinigen perkutanen Bestrahlung mit einer hohen Morbiditaet verbunden ist , empfohlen . Mit der intraoperativen Radiotherapie ist eine lokal begrenzte Dosiseskalation ohne erhoehte perioperative Morbiditaet moeglich . Sowohl in der adjuvanten als auch in der primaeren Behandlung kann die lokale Tumorkontrolle deutlich verbessert werden ( 70-90 % ) . Unter palliativen Gesichtspunkten wird eine rasche und langandauernde Schmerzbesserung bei ueber 60 % der Patienten erreicht . Die Gesamtprognose wird jedoch durch die unveraendert hohe Fernmetastasierungsrate sowohl nach kurativer Resektion als auch bei primaerer Inoperabilitaet relativiert . Die weitere Dosiseskalation ist bei inoperablen Karzinomen durch das hohe Risiko ( 20-30 % ) einer Gastrointestinalblutung limitiert .

[ "Therapiestrategien", "beim", "Pankreaskarzinom", "werden", "bestimmt", "durch", "den", "hohen", "Anteil", "primaer", "nicht", "resektabler", "Karzinome", ",", "der", "hohen", "relativen", "Strahlenresistenz", "und", "der", "hohen", "Fernmetastasierungsrate", ".", "Selbst", "kurativ", "resezierte", "Karzinome", "erfordern", "durch", "ihre", "hohe", "lokale", "Tumorzellpersistenz", "eine", "lokal", "effektive", "adjuvante", "Behandlungsmassnahme", ".", "Die", "Effektivitaet", "einer", "Radiotherapie", "ist", "dosisabhaengig", ".", "Aus", "der", "Analyse", "publizierter", "Daten", "wird", "eine", "Dosis", "von", ">", "50", "Gy", ",", "welche", "bei", "der", "alleinigen", "perkutanen", "Bestrahlung", "mit", "einer", "hohen", "Morbiditaet", "verbunden", "ist", ",", "empfohlen", ".", "Mit", "der", "intraoperativen", "Radiotherapie", "ist", "eine", "lokal", "begrenzte", "Dosiseskalation", "ohne", "erhoehte", "perioperative", "Morbiditaet", "moeglich", ".", "Sowohl", "in", "der", "adjuvanten", "als", "auch", "in", "der", "primaeren", "Behandlung", "kann", "die", "lokale", "Tumorkontrolle", "deutlich", "verbessert", "werden", "(", "70", "-", "90", "%", ")", ".", "Unter", "palliativen", "Gesichtspunkten", "wird", "eine", "rasche", "und", "langandauernde", "Schmerzbesserung", "bei", "ueber", "60", "%", "der", "Patienten", "erreicht", ".", "Die", "Gesamtprognose", "wird", "jedoch", "durch", "die", "unveraendert", "hohe", "Fernmetastasierungsrate", "sowohl", "nach", "kurativer", "Resektion", "als", "auch", "bei", "primaerer", "Inoperabilitaet", "relativiert", ".", "Die", "weitere", "Dosiseskalation", "ist", "bei", "inoperablen", "Karzinomen", "durch", "das", "hohe", "Risiko", "(", "20", "-", "30", "%", ")", "einer", "Gastrointestinalblutung", "limitiert", "." ]

[ "umlsterm" ]

sklerafixierten is an umlsterm, Hinterkammerlinse is an umlsterm, Auge is an umlsterm

DerOpthalmologe.80950564.ger.abstr_task0

Sentence: Hintergrund : Die Positionierung einer sklerafixierten Hinterkammerlinse im vitrektomierten Auge stellt wegen der mangelnden Stabilitaet des Bulbus ein chirurgisches Problem dar . Es wird haeufig mit Hilfe eines Flieringa-Ringes zu loesen versucht , Perfluorkarbon scheint demgegenueber aber Vorteile zu bieten . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Hintergrund : Die Positionierung einer sklerafixierten Hinterkammerlinse im vitrektomierten Auge stellt wegen der mangelnden Stabilitaet des Bulbus ein chirurgisches Problem dar . Es wird haeufig mit Hilfe eines Flieringa-Ringes zu loesen versucht , Perfluorkarbon scheint demgegenueber aber Vorteile zu bieten .

[ "Hintergrund", ":", "Die", "Positionierung", "einer", "sklerafixierten", "Hinterkammerlinse", "im", "vitrektomierten", "Auge", "stellt", "wegen", "der", "mangelnden", "Stabilitaet", "des", "Bulbus", "ein", "chirurgisches", "Problem", "dar", ".", "Es", "wird", "haeufig", "mit", "Hilfe", "eines", "Flieringa", "-", "Ringes", "zu", "loesen", "versucht", ",", "Perfluorkarbon", "scheint", "demgegenueber", "aber", "Vorteile", "zu", "bieten", "." ]

[ "umlsterm" ]

sklerafixierten is an umlsterm, Hinterkammerlinse is an umlsterm, Auge is an umlsterm

DerOpthalmologe.80950564.ger.abstr_task1

Sentence: Hintergrund : Die Positionierung einer sklerafixierten Hinterkammerlinse im vitrektomierten Auge stellt wegen der mangelnden Stabilitaet des Bulbus ein chirurgisches Problem dar . Es wird haeufig mit Hilfe eines Flieringa-Ringes zu loesen versucht , Perfluorkarbon scheint demgegenueber aber Vorteile zu bieten . Instructions: please typing these entity words according to sentence: sklerafixierten, Hinterkammerlinse, Auge Options: umlsterm

[ "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Hintergrund : Die Positionierung einer sklerafixierten Hinterkammerlinse im vitrektomierten Auge stellt wegen der mangelnden Stabilitaet des Bulbus ein chirurgisches Problem dar . Es wird haeufig mit Hilfe eines Flieringa-Ringes zu loesen versucht , Perfluorkarbon scheint demgegenueber aber Vorteile zu bieten .

[ "Hintergrund", ":", "Die", "Positionierung", "einer", "sklerafixierten", "Hinterkammerlinse", "im", "vitrektomierten", "Auge", "stellt", "wegen", "der", "mangelnden", "Stabilitaet", "des", "Bulbus", "ein", "chirurgisches", "Problem", "dar", ".", "Es", "wird", "haeufig", "mit", "Hilfe", "eines", "Flieringa", "-", "Ringes", "zu", "loesen", "versucht", ",", "Perfluorkarbon", "scheint", "demgegenueber", "aber", "Vorteile", "zu", "bieten", "." ]

[ "umlsterm" ]

sklerafixierten, Hinterkammerlinse, Auge

DerOpthalmologe.80950564.ger.abstr_task2

Sentence: Hintergrund : Die Positionierung einer sklerafixierten Hinterkammerlinse im vitrektomierten Auge stellt wegen der mangelnden Stabilitaet des Bulbus ein chirurgisches Problem dar . Es wird haeufig mit Hilfe eines Flieringa-Ringes zu loesen versucht , Perfluorkarbon scheint demgegenueber aber Vorteile zu bieten . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Hintergrund : Die Positionierung einer sklerafixierten Hinterkammerlinse im vitrektomierten Auge stellt wegen der mangelnden Stabilitaet des Bulbus ein chirurgisches Problem dar . Es wird haeufig mit Hilfe eines Flieringa-Ringes zu loesen versucht , Perfluorkarbon scheint demgegenueber aber Vorteile zu bieten .

[ "Hintergrund", ":", "Die", "Positionierung", "einer", "sklerafixierten", "Hinterkammerlinse", "im", "vitrektomierten", "Auge", "stellt", "wegen", "der", "mangelnden", "Stabilitaet", "des", "Bulbus", "ein", "chirurgisches", "Problem", "dar", ".", "Es", "wird", "haeufig", "mit", "Hilfe", "eines", "Flieringa", "-", "Ringes", "zu", "loesen", "versucht", ",", "Perfluorkarbon", "scheint", "demgegenueber", "aber", "Vorteile", "zu", "bieten", "." ]

[ "umlsterm" ]

amoxicilina / ácido clavulánico is a NORMALIZABLES, tobramicina is a NORMALIZABLES, aciclovir is a NORMALIZABLES, látex is a NORMALIZABLES, fibrina is a PROTEINAS, PAS is a NORMALIZABLES

440_task0

Sentence: Niño de ocho años natural y residente en Sierra Leona que consultó al hospital Saint John of God en Sierra Leona por una tumoración en el párpado inferior del ojo izquierdo con un tiempo de evolución de alrededor de un mes. El padre refería un antecedente de contacto con hojas de la papaya. Durante la exploración presentaba una tumoración dura que ocupaba los dos tercios externos del párpado inferior izquierdo, con ulceraciones en la superficie cutánea y en la mucosa de dicho párpado. También existían adenopatías en ambos lados del cuello. El resto de la exploración no presentaba datos relevantes. La imposibilidad de realizar cultivos microbiológicos en el terreno obligó a administrar una cobertura antibiótica sistémica y local como primera opción terapéutica por si se trataba de un proceso infeccioso. Se administró amoxicilina/ácido clavulánico por vía oral, y tobramicina y aciclovir tópicos. Pero el síntoma que más destacaba era la consistencia pétrea de la tumoración, junto con las adenopatías regionales que sugerían un proceso neoformativo. Finalmente, el contacto con la papaya hizo considerar la posibilidad de que se tratara de una dermatitis de contacto al látex que exudan estos frutos cuando están verdes1. Se realizó una biopsia cutánea, que se envió a un hospital de referencia. El estudio anatomopatológico mostró un exudado con fibrina y polinucleares en la zona superficial de la úlcera y un tejido de granulación en las regiones profundas, donde se identificaron histiocitos con inclusiones intranucleares de tipo herpético y células multinucleadas gigantes con núcleos que conenían cuerpos de inclusión intranucleares. El músculo esquelético de la zona más profunda de la biopsia mostraba una reacción inflamatoria focal no específica. La tinción de PAS fue negativa. El diagnóstico fue: lesión ulcerada de características compatibles con infección por herpes virus, acompañada de sobreinfección probablemente bacteriana. A las tres semanas, la tumoración del párpado inferior empezó a disminuir de tamaño, así como la induración, al tiempo que cicatrizaron las ulceraciones. Al mes y medio, la reparación era total. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: NORMALIZABLES, PROTEINAS

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "I-NORMALIZABLES", "I-NORMALIZABLES", "I-NORMALIZABLES", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Niño de ocho años natural y residente en Sierra Leona que consultó al hospital Saint John of God en Sierra Leona por una tumoración en el párpado inferior del ojo izquierdo con un tiempo de evolución de alrededor de un mes. El padre refería un antecedente de contacto con hojas de la papaya. Durante la exploración presentaba una tumoración dura que ocupaba los dos tercios externos del párpado inferior izquierdo, con ulceraciones en la superficie cutánea y en la mucosa de dicho párpado. También existían adenopatías en ambos lados del cuello. El resto de la exploración no presentaba datos relevantes. La imposibilidad de realizar cultivos microbiológicos en el terreno obligó a administrar una cobertura antibiótica sistémica y local como primera opción terapéutica por si se trataba de un proceso infeccioso. Se administró amoxicilina/ácido clavulánico por vía oral, y tobramicina y aciclovir tópicos. Pero el síntoma que más destacaba era la consistencia pétrea de la tumoración, junto con las adenopatías regionales que sugerían un proceso neoformativo. Finalmente, el contacto con la papaya hizo considerar la posibilidad de que se tratara de una dermatitis de contacto al látex que exudan estos frutos cuando están verdes1. Se realizó una biopsia cutánea, que se envió a un hospital de referencia. El estudio anatomopatológico mostró un exudado con fibrina y polinucleares en la zona superficial de la úlcera y un tejido de granulación en las regiones profundas, donde se identificaron histiocitos con inclusiones intranucleares de tipo herpético y células multinucleadas gigantes con núcleos que conenían cuerpos de inclusión intranucleares. El músculo esquelético de la zona más profunda de la biopsia mostraba una reacción inflamatoria focal no específica. La tinción de PAS fue negativa. El diagnóstico fue: lesión ulcerada de características compatibles con infección por herpes virus, acompañada de sobreinfección probablemente bacteriana. A las tres semanas, la tumoración del párpado inferior empezó a disminuir de tamaño, así como la induración, al tiempo que cicatrizaron las ulceraciones. Al mes y medio, la reparación era total.

[ "Niño", "de", "ocho", "años", "natural", "y", "residente", "en", "Sierra", "Leona", "que", "consultó", "al", "hospital", "Saint", "John", "of", "God", "en", "Sierra", "Leona", "por", "una", "tumoración", "en", "el", "párpado", "inferior", "del", "ojo", "izquierdo", "con", "un", "tiempo", "de", "evolución", "de", "alrededor", "de", "un", "mes", ".", "El", "padre", "refería", "un", "antecedente", "de", "contacto", "con", "hojas", "de", "la", "papaya", ".", "\n", "Durante", "la", "exploración", "presentaba", "una", "tumoración", "dura", "que", "ocupaba", "los", "dos", "tercios", "externos", "del", "párpado", "inferior", "izquierdo", ",", "con", "ulceraciones", "en", "la", "superficie", "cutánea", "y", "en", "la", "mucosa", "de", "dicho", "párpado", ".", "También", "existían", "adenopatías", "en", "ambos", "lados", "del", "cuello", ".", "El", "resto", "de", "la", "exploración", "no", "presentaba", "datos", "relevantes", ".", "\n\n", "La", "imposibilidad", "de", "realizar", "cultivos", "microbiológicos", "en", "el", "terreno", "obligó", "a", "administrar", "una", "cobertura", "antibiótica", "sistémica", "y", "local", "como", "primera", "opción", "terapéutica", "por", "si", "se", "trataba", "de", "un", "proceso", "infeccioso", ".", "Se", "administró", "amoxicilina", "/", "ácido", "clavulánico", "por", "vía", "oral", ",", "y", "tobramicina", "y", "aciclovir", "tópicos", ".", "Pero", "el", "síntoma", "que", "más", "destacaba", "era", "la", "consistencia", "pétrea", "de", "la", "tumoración", ",", "junto", "con", "las", "adenopatías", "regionales", "que", "sugerían", "un", "proceso", "neoformativo", ".", "Finalmente", ",", "el", "contacto", "con", "la", "papaya", "hizo", "considerar", "la", "posibilidad", "de", "que", "se", "tratara", "de", "una", "dermatitis", "de", "contacto", "al", "látex", "que", "exudan", "estos", "frutos", "cuando", "están", "verdes1", ".", "Se", "realizó", "una", "biopsia", "cutánea", ",", "que", "se", "envió", "a", "un", "hospital", "de", "referencia", ".", "\n", "El", "estudio", "anatomopatológico", "mostró", "un", "exudado", "con", "fibrina", "y", "polinucleares", "en", "la", "zona", "superficial", "de", "la", "úlcera", "y", "un", "tejido", "de", "granulación", "en", "las", "regiones", "profundas", ",", "donde", "se", "identificaron", "histiocitos", "con", "inclusiones", "intranucleares", "de", "tipo", "herpético", "y", "células", "multinucleadas", "gigantes", "con", "núcleos", "que", "conenían", "cuerpos", "de", "inclusión", "intranucleares", ".", "El", "músculo", "esquelético", "de", "la", "zona", "más", "profunda", "de", "la", "biopsia", "mostraba", "una", "reacción", "inflamatoria", "focal", "no", "específica", ".", "La", "tinción", "de", "PAS", "fue", "negativa", ".", "El", "diagnóstico", "fue", ":", "lesión", "ulcerada", "de", "características", "compatibles", "con", "infección", "por", "herpes", "virus", ",", "acompañada", "de", "sobreinfección", "probablemente", "bacteriana", ".", "\n\n", "A", "las", "tres", "semanas", ",", "la", "tumoración", "del", "párpado", "inferior", "empezó", "a", "disminuir", "de", "tamaño", ",", "así", "como", "la", "induración", ",", "al", "tiempo", "que", "cicatrizaron", "las", "ulceraciones", ".", "Al", "mes", "y", "medio", ",", "la", "reparación", "era", "total", ".", "\n\n" ]

[ "NORMALIZABLES", "PROTEINAS" ]

amoxicilina / ácido clavulánico is a NORMALIZABLES, tobramicina is a NORMALIZABLES, aciclovir is a NORMALIZABLES, látex is a NORMALIZABLES, fibrina is a PROTEINAS, PAS is a NORMALIZABLES

440_task1

Sentence: Niño de ocho años natural y residente en Sierra Leona que consultó al hospital Saint John of God en Sierra Leona por una tumoración en el párpado inferior del ojo izquierdo con un tiempo de evolución de alrededor de un mes. El padre refería un antecedente de contacto con hojas de la papaya. Durante la exploración presentaba una tumoración dura que ocupaba los dos tercios externos del párpado inferior izquierdo, con ulceraciones en la superficie cutánea y en la mucosa de dicho párpado. También existían adenopatías en ambos lados del cuello. El resto de la exploración no presentaba datos relevantes. La imposibilidad de realizar cultivos microbiológicos en el terreno obligó a administrar una cobertura antibiótica sistémica y local como primera opción terapéutica por si se trataba de un proceso infeccioso. Se administró amoxicilina/ácido clavulánico por vía oral, y tobramicina y aciclovir tópicos. Pero el síntoma que más destacaba era la consistencia pétrea de la tumoración, junto con las adenopatías regionales que sugerían un proceso neoformativo. Finalmente, el contacto con la papaya hizo considerar la posibilidad de que se tratara de una dermatitis de contacto al látex que exudan estos frutos cuando están verdes1. Se realizó una biopsia cutánea, que se envió a un hospital de referencia. El estudio anatomopatológico mostró un exudado con fibrina y polinucleares en la zona superficial de la úlcera y un tejido de granulación en las regiones profundas, donde se identificaron histiocitos con inclusiones intranucleares de tipo herpético y células multinucleadas gigantes con núcleos que conenían cuerpos de inclusión intranucleares. El músculo esquelético de la zona más profunda de la biopsia mostraba una reacción inflamatoria focal no específica. La tinción de PAS fue negativa. El diagnóstico fue: lesión ulcerada de características compatibles con infección por herpes virus, acompañada de sobreinfección probablemente bacteriana. A las tres semanas, la tumoración del párpado inferior empezó a disminuir de tamaño, así como la induración, al tiempo que cicatrizaron las ulceraciones. Al mes y medio, la reparación era total. Instructions: please typing these entity words according to sentence: amoxicilina / ácido clavulánico, tobramicina, aciclovir, látex, fibrina, PAS Options: NORMALIZABLES, PROTEINAS

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "I-NORMALIZABLES", "I-NORMALIZABLES", "I-NORMALIZABLES", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Niño de ocho años natural y residente en Sierra Leona que consultó al hospital Saint John of God en Sierra Leona por una tumoración en el párpado inferior del ojo izquierdo con un tiempo de evolución de alrededor de un mes. El padre refería un antecedente de contacto con hojas de la papaya. Durante la exploración presentaba una tumoración dura que ocupaba los dos tercios externos del párpado inferior izquierdo, con ulceraciones en la superficie cutánea y en la mucosa de dicho párpado. También existían adenopatías en ambos lados del cuello. El resto de la exploración no presentaba datos relevantes. La imposibilidad de realizar cultivos microbiológicos en el terreno obligó a administrar una cobertura antibiótica sistémica y local como primera opción terapéutica por si se trataba de un proceso infeccioso. Se administró amoxicilina/ácido clavulánico por vía oral, y tobramicina y aciclovir tópicos. Pero el síntoma que más destacaba era la consistencia pétrea de la tumoración, junto con las adenopatías regionales que sugerían un proceso neoformativo. Finalmente, el contacto con la papaya hizo considerar la posibilidad de que se tratara de una dermatitis de contacto al látex que exudan estos frutos cuando están verdes1. Se realizó una biopsia cutánea, que se envió a un hospital de referencia. El estudio anatomopatológico mostró un exudado con fibrina y polinucleares en la zona superficial de la úlcera y un tejido de granulación en las regiones profundas, donde se identificaron histiocitos con inclusiones intranucleares de tipo herpético y células multinucleadas gigantes con núcleos que conenían cuerpos de inclusión intranucleares. El músculo esquelético de la zona más profunda de la biopsia mostraba una reacción inflamatoria focal no específica. La tinción de PAS fue negativa. El diagnóstico fue: lesión ulcerada de características compatibles con infección por herpes virus, acompañada de sobreinfección probablemente bacteriana. A las tres semanas, la tumoración del párpado inferior empezó a disminuir de tamaño, así como la induración, al tiempo que cicatrizaron las ulceraciones. Al mes y medio, la reparación era total.

[ "Niño", "de", "ocho", "años", "natural", "y", "residente", "en", "Sierra", "Leona", "que", "consultó", "al", "hospital", "Saint", "John", "of", "God", "en", "Sierra", "Leona", "por", "una", "tumoración", "en", "el", "párpado", "inferior", "del", "ojo", "izquierdo", "con", "un", "tiempo", "de", "evolución", "de", "alrededor", "de", "un", "mes", ".", "El", "padre", "refería", "un", "antecedente", "de", "contacto", "con", "hojas", "de", "la", "papaya", ".", "\n", "Durante", "la", "exploración", "presentaba", "una", "tumoración", "dura", "que", "ocupaba", "los", "dos", "tercios", "externos", "del", "párpado", "inferior", "izquierdo", ",", "con", "ulceraciones", "en", "la", "superficie", "cutánea", "y", "en", "la", "mucosa", "de", "dicho", "párpado", ".", "También", "existían", "adenopatías", "en", "ambos", "lados", "del", "cuello", ".", "El", "resto", "de", "la", "exploración", "no", "presentaba", "datos", "relevantes", ".", "\n\n", "La", "imposibilidad", "de", "realizar", "cultivos", "microbiológicos", "en", "el", "terreno", "obligó", "a", "administrar", "una", "cobertura", "antibiótica", "sistémica", "y", "local", "como", "primera", "opción", "terapéutica", "por", "si", "se", "trataba", "de", "un", "proceso", "infeccioso", ".", "Se", "administró", "amoxicilina", "/", "ácido", "clavulánico", "por", "vía", "oral", ",", "y", "tobramicina", "y", "aciclovir", "tópicos", ".", "Pero", "el", "síntoma", "que", "más", "destacaba", "era", "la", "consistencia", "pétrea", "de", "la", "tumoración", ",", "junto", "con", "las", "adenopatías", "regionales", "que", "sugerían", "un", "proceso", "neoformativo", ".", "Finalmente", ",", "el", "contacto", "con", "la", "papaya", "hizo", "considerar", "la", "posibilidad", "de", "que", "se", "tratara", "de", "una", "dermatitis", "de", "contacto", "al", "látex", "que", "exudan", "estos", "frutos", "cuando", "están", "verdes1", ".", "Se", "realizó", "una", "biopsia", "cutánea", ",", "que", "se", "envió", "a", "un", "hospital", "de", "referencia", ".", "\n", "El", "estudio", "anatomopatológico", "mostró", "un", "exudado", "con", "fibrina", "y", "polinucleares", "en", "la", "zona", "superficial", "de", "la", "úlcera", "y", "un", "tejido", "de", "granulación", "en", "las", "regiones", "profundas", ",", "donde", "se", "identificaron", "histiocitos", "con", "inclusiones", "intranucleares", "de", "tipo", "herpético", "y", "células", "multinucleadas", "gigantes", "con", "núcleos", "que", "conenían", "cuerpos", "de", "inclusión", "intranucleares", ".", "El", "músculo", "esquelético", "de", "la", "zona", "más", "profunda", "de", "la", "biopsia", "mostraba", "una", "reacción", "inflamatoria", "focal", "no", "específica", ".", "La", "tinción", "de", "PAS", "fue", "negativa", ".", "El", "diagnóstico", "fue", ":", "lesión", "ulcerada", "de", "características", "compatibles", "con", "infección", "por", "herpes", "virus", ",", "acompañada", "de", "sobreinfección", "probablemente", "bacteriana", ".", "\n\n", "A", "las", "tres", "semanas", ",", "la", "tumoración", "del", "párpado", "inferior", "empezó", "a", "disminuir", "de", "tamaño", ",", "así", "como", "la", "induración", ",", "al", "tiempo", "que", "cicatrizaron", "las", "ulceraciones", ".", "Al", "mes", "y", "medio", ",", "la", "reparación", "era", "total", ".", "\n\n" ]

[ "NORMALIZABLES", "PROTEINAS" ]

amoxicilina / ácido clavulánico, tobramicina, aciclovir, látex, fibrina, PAS

440_task2

Sentence: Niño de ocho años natural y residente en Sierra Leona que consultó al hospital Saint John of God en Sierra Leona por una tumoración en el párpado inferior del ojo izquierdo con un tiempo de evolución de alrededor de un mes. El padre refería un antecedente de contacto con hojas de la papaya. Durante la exploración presentaba una tumoración dura que ocupaba los dos tercios externos del párpado inferior izquierdo, con ulceraciones en la superficie cutánea y en la mucosa de dicho párpado. También existían adenopatías en ambos lados del cuello. El resto de la exploración no presentaba datos relevantes. La imposibilidad de realizar cultivos microbiológicos en el terreno obligó a administrar una cobertura antibiótica sistémica y local como primera opción terapéutica por si se trataba de un proceso infeccioso. Se administró amoxicilina/ácido clavulánico por vía oral, y tobramicina y aciclovir tópicos. Pero el síntoma que más destacaba era la consistencia pétrea de la tumoración, junto con las adenopatías regionales que sugerían un proceso neoformativo. Finalmente, el contacto con la papaya hizo considerar la posibilidad de que se tratara de una dermatitis de contacto al látex que exudan estos frutos cuando están verdes1. Se realizó una biopsia cutánea, que se envió a un hospital de referencia. El estudio anatomopatológico mostró un exudado con fibrina y polinucleares en la zona superficial de la úlcera y un tejido de granulación en las regiones profundas, donde se identificaron histiocitos con inclusiones intranucleares de tipo herpético y células multinucleadas gigantes con núcleos que conenían cuerpos de inclusión intranucleares. El músculo esquelético de la zona más profunda de la biopsia mostraba una reacción inflamatoria focal no específica. La tinción de PAS fue negativa. El diagnóstico fue: lesión ulcerada de características compatibles con infección por herpes virus, acompañada de sobreinfección probablemente bacteriana. A las tres semanas, la tumoración del párpado inferior empezó a disminuir de tamaño, así como la induración, al tiempo que cicatrizaron las ulceraciones. Al mes y medio, la reparación era total. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "I-NORMALIZABLES", "I-NORMALIZABLES", "I-NORMALIZABLES", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PROTEINAS", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-NORMALIZABLES", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Niño de ocho años natural y residente en Sierra Leona que consultó al hospital Saint John of God en Sierra Leona por una tumoración en el párpado inferior del ojo izquierdo con un tiempo de evolución de alrededor de un mes. El padre refería un antecedente de contacto con hojas de la papaya. Durante la exploración presentaba una tumoración dura que ocupaba los dos tercios externos del párpado inferior izquierdo, con ulceraciones en la superficie cutánea y en la mucosa de dicho párpado. También existían adenopatías en ambos lados del cuello. El resto de la exploración no presentaba datos relevantes. La imposibilidad de realizar cultivos microbiológicos en el terreno obligó a administrar una cobertura antibiótica sistémica y local como primera opción terapéutica por si se trataba de un proceso infeccioso. Se administró amoxicilina/ácido clavulánico por vía oral, y tobramicina y aciclovir tópicos. Pero el síntoma que más destacaba era la consistencia pétrea de la tumoración, junto con las adenopatías regionales que sugerían un proceso neoformativo. Finalmente, el contacto con la papaya hizo considerar la posibilidad de que se tratara de una dermatitis de contacto al látex que exudan estos frutos cuando están verdes1. Se realizó una biopsia cutánea, que se envió a un hospital de referencia. El estudio anatomopatológico mostró un exudado con fibrina y polinucleares en la zona superficial de la úlcera y un tejido de granulación en las regiones profundas, donde se identificaron histiocitos con inclusiones intranucleares de tipo herpético y células multinucleadas gigantes con núcleos que conenían cuerpos de inclusión intranucleares. El músculo esquelético de la zona más profunda de la biopsia mostraba una reacción inflamatoria focal no específica. La tinción de PAS fue negativa. El diagnóstico fue: lesión ulcerada de características compatibles con infección por herpes virus, acompañada de sobreinfección probablemente bacteriana. A las tres semanas, la tumoración del párpado inferior empezó a disminuir de tamaño, así como la induración, al tiempo que cicatrizaron las ulceraciones. Al mes y medio, la reparación era total.

[ "Niño", "de", "ocho", "años", "natural", "y", "residente", "en", "Sierra", "Leona", "que", "consultó", "al", "hospital", "Saint", "John", "of", "God", "en", "Sierra", "Leona", "por", "una", "tumoración", "en", "el", "párpado", "inferior", "del", "ojo", "izquierdo", "con", "un", "tiempo", "de", "evolución", "de", "alrededor", "de", "un", "mes", ".", "El", "padre", "refería", "un", "antecedente", "de", "contacto", "con", "hojas", "de", "la", "papaya", ".", "\n", "Durante", "la", "exploración", "presentaba", "una", "tumoración", "dura", "que", "ocupaba", "los", "dos", "tercios", "externos", "del", "párpado", "inferior", "izquierdo", ",", "con", "ulceraciones", "en", "la", "superficie", "cutánea", "y", "en", "la", "mucosa", "de", "dicho", "párpado", ".", "También", "existían", "adenopatías", "en", "ambos", "lados", "del", "cuello", ".", "El", "resto", "de", "la", "exploración", "no", "presentaba", "datos", "relevantes", ".", "\n\n", "La", "imposibilidad", "de", "realizar", "cultivos", "microbiológicos", "en", "el", "terreno", "obligó", "a", "administrar", "una", "cobertura", "antibiótica", "sistémica", "y", "local", "como", "primera", "opción", "terapéutica", "por", "si", "se", "trataba", "de", "un", "proceso", "infeccioso", ".", "Se", "administró", "amoxicilina", "/", "ácido", "clavulánico", "por", "vía", "oral", ",", "y", "tobramicina", "y", "aciclovir", "tópicos", ".", "Pero", "el", "síntoma", "que", "más", "destacaba", "era", "la", "consistencia", "pétrea", "de", "la", "tumoración", ",", "junto", "con", "las", "adenopatías", "regionales", "que", "sugerían", "un", "proceso", "neoformativo", ".", "Finalmente", ",", "el", "contacto", "con", "la", "papaya", "hizo", "considerar", "la", "posibilidad", "de", "que", "se", "tratara", "de", "una", "dermatitis", "de", "contacto", "al", "látex", "que", "exudan", "estos", "frutos", "cuando", "están", "verdes1", ".", "Se", "realizó", "una", "biopsia", "cutánea", ",", "que", "se", "envió", "a", "un", "hospital", "de", "referencia", ".", "\n", "El", "estudio", "anatomopatológico", "mostró", "un", "exudado", "con", "fibrina", "y", "polinucleares", "en", "la", "zona", "superficial", "de", "la", "úlcera", "y", "un", "tejido", "de", "granulación", "en", "las", "regiones", "profundas", ",", "donde", "se", "identificaron", "histiocitos", "con", "inclusiones", "intranucleares", "de", "tipo", "herpético", "y", "células", "multinucleadas", "gigantes", "con", "núcleos", "que", "conenían", "cuerpos", "de", "inclusión", "intranucleares", ".", "El", "músculo", "esquelético", "de", "la", "zona", "más", "profunda", "de", "la", "biopsia", "mostraba", "una", "reacción", "inflamatoria", "focal", "no", "específica", ".", "La", "tinción", "de", "PAS", "fue", "negativa", ".", "El", "diagnóstico", "fue", ":", "lesión", "ulcerada", "de", "características", "compatibles", "con", "infección", "por", "herpes", "virus", ",", "acompañada", "de", "sobreinfección", "probablemente", "bacteriana", ".", "\n\n", "A", "las", "tres", "semanas", ",", "la", "tumoración", "del", "párpado", "inferior", "empezó", "a", "disminuir", "de", "tamaño", ",", "así", "como", "la", "induración", ",", "al", "tiempo", "que", "cicatrizaron", "las", "ulceraciones", ".", "Al", "mes", "y", "medio", ",", "la", "reparación", "era", "total", ".", "\n\n" ]

[ "NORMALIZABLES", "PROTEINAS" ]

Age is a Person, 18 to 75 years old is a Value, male or female is a Scope, posterior or posterolateral is a Scope, disc herniations is a Condition, one level between L1 and S1 is a Qualifier, radiographic confirmation is a Qualifier, neural compression is a Condition, CT and / or MRI is a Scope, At least six ( 6 ) weeks is a Multiplier, failed is a Qualifier, conservative is a Qualifier, treatment is a Procedure, prior to surgery is a Temporal, immediate is a Qualifier, surgery is a Procedure, prevent is a Mood, permanent disability is a Condition, posterior disc height is a Measurement, index level(s ) is a Qualifier, Lower back pain and / or sciatica is a Scope, spinal claudication is a Condition, Oswestry Questionnaire score is a Measurement, at least 40/100 is a Value, at baseline is a Temporal, VAS leg pain is a Measurement, at least 40/100 is a Value, at baseline is a Temporal

NCT03366779_inc_task0

Sentence: Age 18 to 75 years old (male or female). Patients with posterior or posterolateral disc herniations at one level between L1 and S1 with radiographic confirmation of neural compression using CT and/or MRI. At least six (6) weeks of failed, conservative treatment prior to surgery, or requires immediate surgery to prevent permanent disability. Minimum posterior disc height of 5mm at the index level(s). Lower back pain and/or sciatica with or without spinal claudication. Oswestry Questionnaire score of at least 40/100 at baseline. VAS leg pain of at least 40/100 at baseline. Psychosocially, mentally and physically able to fully comply with the clinical protocol and willing to adhere to follow-up schedule and requirements. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Temporal, Condition, Qualifier, Value, Person, Multiplier, Procedure, Scope, Measurement, Mood

[ "B-Person", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "B-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "B-Condition", "I-Condition", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "B-Qualifier", "I-Qualifier", "O", "B-Condition", "I-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "B-Multiplier", "I-Multiplier", "I-Multiplier", "I-Multiplier", "I-Multiplier", "I-Multiplier", "I-Multiplier", "O", "B-Qualifier", "O", "B-Qualifier", "B-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "B-Qualifier", "B-Procedure", "O", "B-Mood", "B-Condition", "I-Condition", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "O", "O", "O", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "I-Value", "B-Temporal", "I-Temporal", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "I-Value", "B-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Age 18 to 75 years old (male or female). Patients with posterior or posterolateral disc herniations at one level between L1 and S1 with radiographic confirmation of neural compression using CT and/or MRI. At least six (6) weeks of failed, conservative treatment prior to surgery, or requires immediate surgery to prevent permanent disability. Minimum posterior disc height of 5mm at the index level(s). Lower back pain and/or sciatica with or without spinal claudication. Oswestry Questionnaire score of at least 40/100 at baseline. VAS leg pain of at least 40/100 at baseline. Psychosocially, mentally and physically able to fully comply with the clinical protocol and willing to adhere to follow-up schedule and requirements.

[ "Age", "18", "to", "75", "years", "old", "(", "male", "or", "female", ")", ".", "\n", "Patients", "with", "posterior", "or", "posterolateral", "disc", "herniations", "at", "one", "level", "between", "L1", "and", "S1", "with", "radiographic", "confirmation", "of", "neural", "compression", "using", "CT", "and", "/", "or", "MRI", ".", "\n", "At", "least", "six", "(", "6", ")", "weeks", "of", "failed", ",", "conservative", "treatment", "prior", "to", "surgery", ",", "or", "requires", "immediate", "surgery", "to", "prevent", "permanent", "disability", ".", "\n", "Minimum", "posterior", "disc", "height", "of", "5", "mm", "at", "the", "index", "level(s", ")", ".", "\n", "Lower", "back", "pain", "and", "/", "or", "sciatica", "with", "or", "without", "spinal", "claudication", ".", "\n", "Oswestry", "Questionnaire", "score", "of", "at", "least", "40/100", "at", "baseline", ".", "\n", "VAS", "leg", "pain", "of", "at", "least", "40/100", "at", "baseline", ".", "\n", "Psychosocially", ",", "mentally", "and", "physically", "able", "to", "fully", "comply", "with", "the", "clinical", "protocol", "and", "willing", "to", "adhere", "to", "follow", "-", "up", "schedule", "and", "requirements", ".", "\n" ]

[ "Scope", "Measurement", "Qualifier", "Multiplier", "Condition", "Value", "Temporal", "Procedure", "Mood", "Person" ]

Age is a Person, 18 to 75 years old is a Value, male or female is a Scope, posterior or posterolateral is a Scope, disc herniations is a Condition, one level between L1 and S1 is a Qualifier, radiographic confirmation is a Qualifier, neural compression is a Condition, CT and / or MRI is a Scope, At least six ( 6 ) weeks is a Multiplier, failed is a Qualifier, conservative is a Qualifier, treatment is a Procedure, prior to surgery is a Temporal, immediate is a Qualifier, surgery is a Procedure, prevent is a Mood, permanent disability is a Condition, posterior disc height is a Measurement, index level(s ) is a Qualifier, Lower back pain and / or sciatica is a Scope, spinal claudication is a Condition, Oswestry Questionnaire score is a Measurement, at least 40/100 is a Value, at baseline is a Temporal, VAS leg pain is a Measurement, at least 40/100 is a Value, at baseline is a Temporal

NCT03366779_inc_task1

Sentence: Age 18 to 75 years old (male or female). Patients with posterior or posterolateral disc herniations at one level between L1 and S1 with radiographic confirmation of neural compression using CT and/or MRI. At least six (6) weeks of failed, conservative treatment prior to surgery, or requires immediate surgery to prevent permanent disability. Minimum posterior disc height of 5mm at the index level(s). Lower back pain and/or sciatica with or without spinal claudication. Oswestry Questionnaire score of at least 40/100 at baseline. VAS leg pain of at least 40/100 at baseline. Psychosocially, mentally and physically able to fully comply with the clinical protocol and willing to adhere to follow-up schedule and requirements. Instructions: please typing these entity words according to sentence: Age, 18 to 75 years old, male or female, posterior or posterolateral, disc herniations, one level between L1 and S1, radiographic confirmation, neural compression, CT and / or MRI, At least six ( 6 ) weeks, failed, conservative, treatment, prior to surgery, immediate, surgery, prevent, permanent disability, posterior disc height, index level(s ), Lower back pain and / or sciatica, spinal claudication, Oswestry Questionnaire score, at least 40/100, at baseline, VAS leg pain, at least 40/100, at baseline Options: Temporal, Condition, Qualifier, Value, Person, Multiplier, Procedure, Scope, Measurement, Mood

[ "B-Person", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "B-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "B-Condition", "I-Condition", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "B-Qualifier", "I-Qualifier", "O", "B-Condition", "I-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "B-Multiplier", "I-Multiplier", "I-Multiplier", "I-Multiplier", "I-Multiplier", "I-Multiplier", "I-Multiplier", "O", "B-Qualifier", "O", "B-Qualifier", "B-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "B-Qualifier", "B-Procedure", "O", "B-Mood", "B-Condition", "I-Condition", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "O", "O", "O", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "I-Value", "B-Temporal", "I-Temporal", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "I-Value", "B-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Age 18 to 75 years old (male or female). Patients with posterior or posterolateral disc herniations at one level between L1 and S1 with radiographic confirmation of neural compression using CT and/or MRI. At least six (6) weeks of failed, conservative treatment prior to surgery, or requires immediate surgery to prevent permanent disability. Minimum posterior disc height of 5mm at the index level(s). Lower back pain and/or sciatica with or without spinal claudication. Oswestry Questionnaire score of at least 40/100 at baseline. VAS leg pain of at least 40/100 at baseline. Psychosocially, mentally and physically able to fully comply with the clinical protocol and willing to adhere to follow-up schedule and requirements.

[ "Age", "18", "to", "75", "years", "old", "(", "male", "or", "female", ")", ".", "\n", "Patients", "with", "posterior", "or", "posterolateral", "disc", "herniations", "at", "one", "level", "between", "L1", "and", "S1", "with", "radiographic", "confirmation", "of", "neural", "compression", "using", "CT", "and", "/", "or", "MRI", ".", "\n", "At", "least", "six", "(", "6", ")", "weeks", "of", "failed", ",", "conservative", "treatment", "prior", "to", "surgery", ",", "or", "requires", "immediate", "surgery", "to", "prevent", "permanent", "disability", ".", "\n", "Minimum", "posterior", "disc", "height", "of", "5", "mm", "at", "the", "index", "level(s", ")", ".", "\n", "Lower", "back", "pain", "and", "/", "or", "sciatica", "with", "or", "without", "spinal", "claudication", ".", "\n", "Oswestry", "Questionnaire", "score", "of", "at", "least", "40/100", "at", "baseline", ".", "\n", "VAS", "leg", "pain", "of", "at", "least", "40/100", "at", "baseline", ".", "\n", "Psychosocially", ",", "mentally", "and", "physically", "able", "to", "fully", "comply", "with", "the", "clinical", "protocol", "and", "willing", "to", "adhere", "to", "follow", "-", "up", "schedule", "and", "requirements", ".", "\n" ]

[ "Scope", "Measurement", "Qualifier", "Multiplier", "Condition", "Value", "Temporal", "Procedure", "Mood", "Person" ]

Age, 18 to 75 years old, male or female, posterior or posterolateral, disc herniations, one level between L1 and S1, radiographic confirmation, neural compression, CT and / or MRI, At least six ( 6 ) weeks, failed, conservative, treatment, prior to surgery, immediate, surgery, prevent, permanent disability, posterior disc height, index level(s ), Lower back pain and / or sciatica, spinal claudication, Oswestry Questionnaire score, at least 40/100, at baseline, VAS leg pain, at least 40/100, at baseline

NCT03366779_inc_task2

Sentence: Age 18 to 75 years old (male or female). Patients with posterior or posterolateral disc herniations at one level between L1 and S1 with radiographic confirmation of neural compression using CT and/or MRI. At least six (6) weeks of failed, conservative treatment prior to surgery, or requires immediate surgery to prevent permanent disability. Minimum posterior disc height of 5mm at the index level(s). Lower back pain and/or sciatica with or without spinal claudication. Oswestry Questionnaire score of at least 40/100 at baseline. VAS leg pain of at least 40/100 at baseline. Psychosocially, mentally and physically able to fully comply with the clinical protocol and willing to adhere to follow-up schedule and requirements. Instructions: please extract entity words from the input sentence

[ "B-Person", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "B-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "B-Condition", "I-Condition", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "B-Qualifier", "I-Qualifier", "O", "B-Condition", "I-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "B-Multiplier", "I-Multiplier", "I-Multiplier", "I-Multiplier", "I-Multiplier", "I-Multiplier", "I-Multiplier", "O", "B-Qualifier", "O", "B-Qualifier", "B-Procedure", "B-Temporal", "I-Temporal", "I-Temporal", "O", "O", "O", "B-Qualifier", "B-Procedure", "O", "B-Mood", "B-Condition", "I-Condition", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "O", "O", "O", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "B-Condition", "I-Condition", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "I-Value", "B-Temporal", "I-Temporal", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "O", "B-Value", "I-Value", "I-Value", "B-Temporal", "I-Temporal", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Age 18 to 75 years old (male or female). Patients with posterior or posterolateral disc herniations at one level between L1 and S1 with radiographic confirmation of neural compression using CT and/or MRI. At least six (6) weeks of failed, conservative treatment prior to surgery, or requires immediate surgery to prevent permanent disability. Minimum posterior disc height of 5mm at the index level(s). Lower back pain and/or sciatica with or without spinal claudication. Oswestry Questionnaire score of at least 40/100 at baseline. VAS leg pain of at least 40/100 at baseline. Psychosocially, mentally and physically able to fully comply with the clinical protocol and willing to adhere to follow-up schedule and requirements.

[ "Age", "18", "to", "75", "years", "old", "(", "male", "or", "female", ")", ".", "\n", "Patients", "with", "posterior", "or", "posterolateral", "disc", "herniations", "at", "one", "level", "between", "L1", "and", "S1", "with", "radiographic", "confirmation", "of", "neural", "compression", "using", "CT", "and", "/", "or", "MRI", ".", "\n", "At", "least", "six", "(", "6", ")", "weeks", "of", "failed", ",", "conservative", "treatment", "prior", "to", "surgery", ",", "or", "requires", "immediate", "surgery", "to", "prevent", "permanent", "disability", ".", "\n", "Minimum", "posterior", "disc", "height", "of", "5", "mm", "at", "the", "index", "level(s", ")", ".", "\n", "Lower", "back", "pain", "and", "/", "or", "sciatica", "with", "or", "without", "spinal", "claudication", ".", "\n", "Oswestry", "Questionnaire", "score", "of", "at", "least", "40/100", "at", "baseline", ".", "\n", "VAS", "leg", "pain", "of", "at", "least", "40/100", "at", "baseline", ".", "\n", "Psychosocially", ",", "mentally", "and", "physically", "able", "to", "fully", "comply", "with", "the", "clinical", "protocol", "and", "willing", "to", "adhere", "to", "follow", "-", "up", "schedule", "and", "requirements", ".", "\n" ]

[ "Scope", "Measurement", "Qualifier", "Multiplier", "Condition", "Value", "Temporal", "Procedure", "Mood", "Person" ]

Kopf - Hals - Bereich is an umlsterm, radiologischen is an umlsterm, Diagnostik is an umlsterm, Kopf - Hals - Radiologie is an umlsterm, Persoenlichkeiten is an umlsterm, Geschichte is an umlsterm, Roentgenstrahlen is an umlsterm, Schaedelinnere is an umlsterm, Halsstrukturen is an umlsterm, Spezialprojektionen is an umlsterm, Tomographie is an umlsterm, Computertomographie is an umlsterm, Magnetresonanztomographie is an umlsterm, Arbeit is an umlsterm, Fortbildung is an umlsterm, Kopf is an umlsterm, Hals is an umlsterm

DerRadiologe.60360175.ger.abstr_task0

Sentence: Der Kopf-Hals-Bereich ist im Vergleich zu den anderen Regionen der radiologischen Diagnostik ein begrenztes Gebiet . Trotzdem hat die Kopf-Hals-Radiologie eine lange , interessante und von hervorragenden medizinischen Persoenlichkeiten gepraegte Geschichte . Wenn man beruecksichtigt , dass vor der Entdeckung der Roentgenstrahlen Einblicke in das Schaedelinnere und die Halsstrukturen ohne Sektion oder Operation ueberhaupt nicht moeglich waren , bedeutete bereits die Einfuehrung der Summationsaufnahmen und die Erarbeitung von Spezialprojektionen ein entscheidender Schritt . Ein zweiter diagnostischer Durchbruch erfolgte in den 50er Jahren dieses Jahrhunderts durch die Entwicklung der Schnittbildverfahren . Diese fuehrten zunaechst als konventionelle Tomographie , dann als Computertomographie und Magnetresonanztomographie zu erstaunlichen und unerwarteten Ergebnissen . Im MRT-Bereich ist diese Entwicklung noch nicht abgeschlossen . Intensivere medizinisch-wissenschaftliche Arbeit und gezieltere Fortbildung , auch in europaeischem Rahmen , erscheinen erforderlich , um dieser Entwicklung gerade im Spezialbereich Kopf und Hals gerecht zu werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O" ]

Der Kopf-Hals-Bereich ist im Vergleich zu den anderen Regionen der radiologischen Diagnostik ein begrenztes Gebiet . Trotzdem hat die Kopf-Hals-Radiologie eine lange , interessante und von hervorragenden medizinischen Persoenlichkeiten gepraegte Geschichte . Wenn man beruecksichtigt , dass vor der Entdeckung der Roentgenstrahlen Einblicke in das Schaedelinnere und die Halsstrukturen ohne Sektion oder Operation ueberhaupt nicht moeglich waren , bedeutete bereits die Einfuehrung der Summationsaufnahmen und die Erarbeitung von Spezialprojektionen ein entscheidender Schritt . Ein zweiter diagnostischer Durchbruch erfolgte in den 50er Jahren dieses Jahrhunderts durch die Entwicklung der Schnittbildverfahren . Diese fuehrten zunaechst als konventionelle Tomographie , dann als Computertomographie und Magnetresonanztomographie zu erstaunlichen und unerwarteten Ergebnissen . Im MRT-Bereich ist diese Entwicklung noch nicht abgeschlossen . Intensivere medizinisch-wissenschaftliche Arbeit und gezieltere Fortbildung , auch in europaeischem Rahmen , erscheinen erforderlich , um dieser Entwicklung gerade im Spezialbereich Kopf und Hals gerecht zu werden .

[ "Der", "Kopf", "-", "Hals", "-", "Bereich", "ist", "im", "Vergleich", "zu", "den", "anderen", "Regionen", "der", "radiologischen", "Diagnostik", "ein", "begrenztes", "Gebiet", ".", "Trotzdem", "hat", "die", "Kopf", "-", "Hals", "-", "Radiologie", "eine", "lange", ",", "interessante", "und", "von", "hervorragenden", "medizinischen", "Persoenlichkeiten", "gepraegte", "Geschichte", ".", "Wenn", "man", "beruecksichtigt", ",", "dass", "vor", "der", "Entdeckung", "der", "Roentgenstrahlen", "Einblicke", "in", "das", "Schaedelinnere", "und", "die", "Halsstrukturen", "ohne", "Sektion", "oder", "Operation", "ueberhaupt", "nicht", "moeglich", "waren", ",", "bedeutete", "bereits", "die", "Einfuehrung", "der", "Summationsaufnahmen", "und", "die", "Erarbeitung", "von", "Spezialprojektionen", "ein", "entscheidender", "Schritt", ".", "Ein", "zweiter", "diagnostischer", "Durchbruch", "erfolgte", "in", "den", "50er", "Jahren", "dieses", "Jahrhunderts", "durch", "die", "Entwicklung", "der", "Schnittbildverfahren", ".", "Diese", "fuehrten", "zunaechst", "als", "konventionelle", "Tomographie", ",", "dann", "als", "Computertomographie", "und", "Magnetresonanztomographie", "zu", "erstaunlichen", "und", "unerwarteten", "Ergebnissen", ".", "Im", "MRT", "-", "Bereich", "ist", "diese", "Entwicklung", "noch", "nicht", "abgeschlossen", ".", "Intensivere", "medizinisch", "-", "wissenschaftliche", "Arbeit", "und", "gezieltere", "Fortbildung", ",", "auch", "in", "europaeischem", "Rahmen", ",", "erscheinen", "erforderlich", ",", "um", "dieser", "Entwicklung", "gerade", "im", "Spezialbereich", "Kopf", "und", "Hals", "gerecht", "zu", "werden", "." ]

[ "umlsterm" ]

Kopf - Hals - Bereich is an umlsterm, radiologischen is an umlsterm, Diagnostik is an umlsterm, Kopf - Hals - Radiologie is an umlsterm, Persoenlichkeiten is an umlsterm, Geschichte is an umlsterm, Roentgenstrahlen is an umlsterm, Schaedelinnere is an umlsterm, Halsstrukturen is an umlsterm, Spezialprojektionen is an umlsterm, Tomographie is an umlsterm, Computertomographie is an umlsterm, Magnetresonanztomographie is an umlsterm, Arbeit is an umlsterm, Fortbildung is an umlsterm, Kopf is an umlsterm, Hals is an umlsterm

DerRadiologe.60360175.ger.abstr_task1

Sentence: Der Kopf-Hals-Bereich ist im Vergleich zu den anderen Regionen der radiologischen Diagnostik ein begrenztes Gebiet . Trotzdem hat die Kopf-Hals-Radiologie eine lange , interessante und von hervorragenden medizinischen Persoenlichkeiten gepraegte Geschichte . Wenn man beruecksichtigt , dass vor der Entdeckung der Roentgenstrahlen Einblicke in das Schaedelinnere und die Halsstrukturen ohne Sektion oder Operation ueberhaupt nicht moeglich waren , bedeutete bereits die Einfuehrung der Summationsaufnahmen und die Erarbeitung von Spezialprojektionen ein entscheidender Schritt . Ein zweiter diagnostischer Durchbruch erfolgte in den 50er Jahren dieses Jahrhunderts durch die Entwicklung der Schnittbildverfahren . Diese fuehrten zunaechst als konventionelle Tomographie , dann als Computertomographie und Magnetresonanztomographie zu erstaunlichen und unerwarteten Ergebnissen . Im MRT-Bereich ist diese Entwicklung noch nicht abgeschlossen . Intensivere medizinisch-wissenschaftliche Arbeit und gezieltere Fortbildung , auch in europaeischem Rahmen , erscheinen erforderlich , um dieser Entwicklung gerade im Spezialbereich Kopf und Hals gerecht zu werden . Instructions: please typing these entity words according to sentence: Kopf - Hals - Bereich, radiologischen, Diagnostik, Kopf - Hals - Radiologie, Persoenlichkeiten, Geschichte, Roentgenstrahlen, Schaedelinnere, Halsstrukturen, Spezialprojektionen, Tomographie, Computertomographie, Magnetresonanztomographie, Arbeit, Fortbildung, Kopf, Hals Options: umlsterm

[ "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O" ]

Der Kopf-Hals-Bereich ist im Vergleich zu den anderen Regionen der radiologischen Diagnostik ein begrenztes Gebiet . Trotzdem hat die Kopf-Hals-Radiologie eine lange , interessante und von hervorragenden medizinischen Persoenlichkeiten gepraegte Geschichte . Wenn man beruecksichtigt , dass vor der Entdeckung der Roentgenstrahlen Einblicke in das Schaedelinnere und die Halsstrukturen ohne Sektion oder Operation ueberhaupt nicht moeglich waren , bedeutete bereits die Einfuehrung der Summationsaufnahmen und die Erarbeitung von Spezialprojektionen ein entscheidender Schritt . Ein zweiter diagnostischer Durchbruch erfolgte in den 50er Jahren dieses Jahrhunderts durch die Entwicklung der Schnittbildverfahren . Diese fuehrten zunaechst als konventionelle Tomographie , dann als Computertomographie und Magnetresonanztomographie zu erstaunlichen und unerwarteten Ergebnissen . Im MRT-Bereich ist diese Entwicklung noch nicht abgeschlossen . Intensivere medizinisch-wissenschaftliche Arbeit und gezieltere Fortbildung , auch in europaeischem Rahmen , erscheinen erforderlich , um dieser Entwicklung gerade im Spezialbereich Kopf und Hals gerecht zu werden .

[ "Der", "Kopf", "-", "Hals", "-", "Bereich", "ist", "im", "Vergleich", "zu", "den", "anderen", "Regionen", "der", "radiologischen", "Diagnostik", "ein", "begrenztes", "Gebiet", ".", "Trotzdem", "hat", "die", "Kopf", "-", "Hals", "-", "Radiologie", "eine", "lange", ",", "interessante", "und", "von", "hervorragenden", "medizinischen", "Persoenlichkeiten", "gepraegte", "Geschichte", ".", "Wenn", "man", "beruecksichtigt", ",", "dass", "vor", "der", "Entdeckung", "der", "Roentgenstrahlen", "Einblicke", "in", "das", "Schaedelinnere", "und", "die", "Halsstrukturen", "ohne", "Sektion", "oder", "Operation", "ueberhaupt", "nicht", "moeglich", "waren", ",", "bedeutete", "bereits", "die", "Einfuehrung", "der", "Summationsaufnahmen", "und", "die", "Erarbeitung", "von", "Spezialprojektionen", "ein", "entscheidender", "Schritt", ".", "Ein", "zweiter", "diagnostischer", "Durchbruch", "erfolgte", "in", "den", "50er", "Jahren", "dieses", "Jahrhunderts", "durch", "die", "Entwicklung", "der", "Schnittbildverfahren", ".", "Diese", "fuehrten", "zunaechst", "als", "konventionelle", "Tomographie", ",", "dann", "als", "Computertomographie", "und", "Magnetresonanztomographie", "zu", "erstaunlichen", "und", "unerwarteten", "Ergebnissen", ".", "Im", "MRT", "-", "Bereich", "ist", "diese", "Entwicklung", "noch", "nicht", "abgeschlossen", ".", "Intensivere", "medizinisch", "-", "wissenschaftliche", "Arbeit", "und", "gezieltere", "Fortbildung", ",", "auch", "in", "europaeischem", "Rahmen", ",", "erscheinen", "erforderlich", ",", "um", "dieser", "Entwicklung", "gerade", "im", "Spezialbereich", "Kopf", "und", "Hals", "gerecht", "zu", "werden", "." ]

[ "umlsterm" ]

Kopf - Hals - Bereich, radiologischen, Diagnostik, Kopf - Hals - Radiologie, Persoenlichkeiten, Geschichte, Roentgenstrahlen, Schaedelinnere, Halsstrukturen, Spezialprojektionen, Tomographie, Computertomographie, Magnetresonanztomographie, Arbeit, Fortbildung, Kopf, Hals

DerRadiologe.60360175.ger.abstr_task2

Sentence: Der Kopf-Hals-Bereich ist im Vergleich zu den anderen Regionen der radiologischen Diagnostik ein begrenztes Gebiet . Trotzdem hat die Kopf-Hals-Radiologie eine lange , interessante und von hervorragenden medizinischen Persoenlichkeiten gepraegte Geschichte . Wenn man beruecksichtigt , dass vor der Entdeckung der Roentgenstrahlen Einblicke in das Schaedelinnere und die Halsstrukturen ohne Sektion oder Operation ueberhaupt nicht moeglich waren , bedeutete bereits die Einfuehrung der Summationsaufnahmen und die Erarbeitung von Spezialprojektionen ein entscheidender Schritt . Ein zweiter diagnostischer Durchbruch erfolgte in den 50er Jahren dieses Jahrhunderts durch die Entwicklung der Schnittbildverfahren . Diese fuehrten zunaechst als konventionelle Tomographie , dann als Computertomographie und Magnetresonanztomographie zu erstaunlichen und unerwarteten Ergebnissen . Im MRT-Bereich ist diese Entwicklung noch nicht abgeschlossen . Intensivere medizinisch-wissenschaftliche Arbeit und gezieltere Fortbildung , auch in europaeischem Rahmen , erscheinen erforderlich , um dieser Entwicklung gerade im Spezialbereich Kopf und Hals gerecht zu werden . Instructions: please extract entity words from the input sentence

[ "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O" ]

Der Kopf-Hals-Bereich ist im Vergleich zu den anderen Regionen der radiologischen Diagnostik ein begrenztes Gebiet . Trotzdem hat die Kopf-Hals-Radiologie eine lange , interessante und von hervorragenden medizinischen Persoenlichkeiten gepraegte Geschichte . Wenn man beruecksichtigt , dass vor der Entdeckung der Roentgenstrahlen Einblicke in das Schaedelinnere und die Halsstrukturen ohne Sektion oder Operation ueberhaupt nicht moeglich waren , bedeutete bereits die Einfuehrung der Summationsaufnahmen und die Erarbeitung von Spezialprojektionen ein entscheidender Schritt . Ein zweiter diagnostischer Durchbruch erfolgte in den 50er Jahren dieses Jahrhunderts durch die Entwicklung der Schnittbildverfahren . Diese fuehrten zunaechst als konventionelle Tomographie , dann als Computertomographie und Magnetresonanztomographie zu erstaunlichen und unerwarteten Ergebnissen . Im MRT-Bereich ist diese Entwicklung noch nicht abgeschlossen . Intensivere medizinisch-wissenschaftliche Arbeit und gezieltere Fortbildung , auch in europaeischem Rahmen , erscheinen erforderlich , um dieser Entwicklung gerade im Spezialbereich Kopf und Hals gerecht zu werden .

[ "Der", "Kopf", "-", "Hals", "-", "Bereich", "ist", "im", "Vergleich", "zu", "den", "anderen", "Regionen", "der", "radiologischen", "Diagnostik", "ein", "begrenztes", "Gebiet", ".", "Trotzdem", "hat", "die", "Kopf", "-", "Hals", "-", "Radiologie", "eine", "lange", ",", "interessante", "und", "von", "hervorragenden", "medizinischen", "Persoenlichkeiten", "gepraegte", "Geschichte", ".", "Wenn", "man", "beruecksichtigt", ",", "dass", "vor", "der", "Entdeckung", "der", "Roentgenstrahlen", "Einblicke", "in", "das", "Schaedelinnere", "und", "die", "Halsstrukturen", "ohne", "Sektion", "oder", "Operation", "ueberhaupt", "nicht", "moeglich", "waren", ",", "bedeutete", "bereits", "die", "Einfuehrung", "der", "Summationsaufnahmen", "und", "die", "Erarbeitung", "von", "Spezialprojektionen", "ein", "entscheidender", "Schritt", ".", "Ein", "zweiter", "diagnostischer", "Durchbruch", "erfolgte", "in", "den", "50er", "Jahren", "dieses", "Jahrhunderts", "durch", "die", "Entwicklung", "der", "Schnittbildverfahren", ".", "Diese", "fuehrten", "zunaechst", "als", "konventionelle", "Tomographie", ",", "dann", "als", "Computertomographie", "und", "Magnetresonanztomographie", "zu", "erstaunlichen", "und", "unerwarteten", "Ergebnissen", ".", "Im", "MRT", "-", "Bereich", "ist", "diese", "Entwicklung", "noch", "nicht", "abgeschlossen", ".", "Intensivere", "medizinisch", "-", "wissenschaftliche", "Arbeit", "und", "gezieltere", "Fortbildung", ",", "auch", "in", "europaeischem", "Rahmen", ",", "erscheinen", "erforderlich", ",", "um", "dieser", "Entwicklung", "gerade", "im", "Spezialbereich", "Kopf", "und", "Hals", "gerecht", "zu", "werden", "." ]

[ "umlsterm" ]

CONSTANS is a Protein, COP1 is a Protein, FLOWERING LOCUS T is a Protein, FT is a Protein, CONSTANS is a Protein, CO is a Protein, FT is a Protein, CO is a Protein, CO is a Protein, COP1 is a Protein, COP1 is a Protein, CO is a Protein, CO is a Protein, CO is a Protein, COP1 is a Protein, ubiquitin is a Protein, CO is a Protein, COP1 is a Protein, CO is a Protein, FT is a Protein

305_task0

Sentence: COP1-mediated ubiquitination of CONSTANS is implicated in cryptochrome regulation of flowering in Arabidopsis. In Arabidopsis thaliana, the blue light photoreceptor cryptochromes (CRY) act to promote photomorphogenic development and the transition from vegetative to floral development in long days (LDs). We previously proposed that one of the mechanisms by which CRY regulates light responses is via its physical interaction with COP1, a RING motif-containing E3 ligase. Under LDs, the transcription of FLOWERING LOCUS T (FT) is activated by CONSTANS (CO) in leaf, and the FT protein moves to the shoot apex to induce flowering. CO protein is degraded in darkness, whereas it is stabilized by the CRY-mediated signal. However, the mechanism underlying this process is unknown. We show in this report that CO acts genetically downstream of COP1 and CRY to regulate flowering time. In addition, COP1 physically interacts with CO and functions as an E3 ligase, ubiquitinating CO in vitro and reducing CO levels in vivo. These results suggest that COP1 acts as a repressor of flowering by promoting the ubiquitin-mediated proteolysis of CO in darkness and that CRY-mediated signal may negatively regulate COP1, thereby stabilizing CO, activating FT transcription, and inducing flowering. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein

[ "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O" ]

COP1-mediated ubiquitination of CONSTANS is implicated in cryptochrome regulation of flowering in Arabidopsis. In Arabidopsis thaliana, the blue light photoreceptor cryptochromes (CRY) act to promote photomorphogenic development and the transition from vegetative to floral development in long days (LDs). We previously proposed that one of the mechanisms by which CRY regulates light responses is via its physical interaction with COP1, a RING motif-containing E3 ligase. Under LDs, the transcription of FLOWERING LOCUS T (FT) is activated by CONSTANS (CO) in leaf, and the FT protein moves to the shoot apex to induce flowering. CO protein is degraded in darkness, whereas it is stabilized by the CRY-mediated signal. However, the mechanism underlying this process is unknown. We show in this report that CO acts genetically downstream of COP1 and CRY to regulate flowering time. In addition, COP1 physically interacts with CO and functions as an E3 ligase, ubiquitinating CO in vitro and reducing CO levels in vivo. These results suggest that COP1 acts as a repressor of flowering by promoting the ubiquitin-mediated proteolysis of CO in darkness and that CRY-mediated signal may negatively regulate COP1, thereby stabilizing CO, activating FT transcription, and inducing flowering.

[ "COP1-mediated", "ubiquitination", "of", "CONSTANS", "is", "implicated", "in", "cryptochrome", "regulation", "of", "flowering", "in", "Arabidopsis", ".", "\n", "In", "Arabidopsis", "thaliana", ",", "the", "blue", "light", "photoreceptor", "cryptochromes", "(", "CRY", ")", "act", "to", "promote", "photomorphogenic", "development", "and", "the", "transition", "from", "vegetative", "to", "floral", "development", "in", "long", "days", "(", "LDs", ")", ".", "We", "previously", "proposed", "that", "one", "of", "the", "mechanisms", "by", "which", "CRY", "regulates", "light", "responses", "is", "via", "its", "physical", "interaction", "with", "COP1", ",", "a", "RING", "motif", "-", "containing", "E3", "ligase", ".", "Under", "LDs", ",", "the", "transcription", "of", "FLOWERING", "LOCUS", "T", "(", "FT", ")", "is", "activated", "by", "CONSTANS", "(", "CO", ")", "in", "leaf", ",", "and", "the", "FT", "protein", "moves", "to", "the", "shoot", "apex", "to", "induce", "flowering", ".", "CO", "protein", "is", "degraded", "in", "darkness", ",", "whereas", "it", "is", "stabilized", "by", "the", "CRY", "-", "mediated", "signal", ".", "However", ",", "the", "mechanism", "underlying", "this", "process", "is", "unknown", ".", "We", "show", "in", "this", "report", "that", "CO", "acts", "genetically", "downstream", "of", "COP1", "and", "CRY", "to", "regulate", "flowering", "time", ".", "In", "addition", ",", "COP1", "physically", "interacts", "with", "CO", "and", "functions", "as", "an", "E3", "ligase", ",", "ubiquitinating", "CO", "in", "vitro", "and", "reducing", "CO", "levels", "in", "vivo", ".", "These", "results", "suggest", "that", "COP1", "acts", "as", "a", "repressor", "of", "flowering", "by", "promoting", "the", "ubiquitin", "-", "mediated", "proteolysis", "of", "CO", "in", "darkness", "and", "that", "CRY", "-", "mediated", "signal", "may", "negatively", "regulate", "COP1", ",", "thereby", "stabilizing", "CO", ",", "activating", "FT", "transcription", ",", "and", "inducing", "flowering", ".", "\n" ]

[ "Protein" ]

CONSTANS is a Protein, COP1 is a Protein, FLOWERING LOCUS T is a Protein, FT is a Protein, CONSTANS is a Protein, CO is a Protein, FT is a Protein, CO is a Protein, CO is a Protein, COP1 is a Protein, COP1 is a Protein, CO is a Protein, CO is a Protein, CO is a Protein, COP1 is a Protein, ubiquitin is a Protein, CO is a Protein, COP1 is a Protein, CO is a Protein, FT is a Protein

305_task1

Sentence: COP1-mediated ubiquitination of CONSTANS is implicated in cryptochrome regulation of flowering in Arabidopsis. In Arabidopsis thaliana, the blue light photoreceptor cryptochromes (CRY) act to promote photomorphogenic development and the transition from vegetative to floral development in long days (LDs). We previously proposed that one of the mechanisms by which CRY regulates light responses is via its physical interaction with COP1, a RING motif-containing E3 ligase. Under LDs, the transcription of FLOWERING LOCUS T (FT) is activated by CONSTANS (CO) in leaf, and the FT protein moves to the shoot apex to induce flowering. CO protein is degraded in darkness, whereas it is stabilized by the CRY-mediated signal. However, the mechanism underlying this process is unknown. We show in this report that CO acts genetically downstream of COP1 and CRY to regulate flowering time. In addition, COP1 physically interacts with CO and functions as an E3 ligase, ubiquitinating CO in vitro and reducing CO levels in vivo. These results suggest that COP1 acts as a repressor of flowering by promoting the ubiquitin-mediated proteolysis of CO in darkness and that CRY-mediated signal may negatively regulate COP1, thereby stabilizing CO, activating FT transcription, and inducing flowering. Instructions: please typing these entity words according to sentence: CONSTANS, COP1, FLOWERING LOCUS T, FT, CONSTANS, CO, FT, CO, CO, COP1, COP1, CO, CO, CO, COP1, ubiquitin, CO, COP1, CO, FT Options: Protein

[ "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O" ]

COP1-mediated ubiquitination of CONSTANS is implicated in cryptochrome regulation of flowering in Arabidopsis. In Arabidopsis thaliana, the blue light photoreceptor cryptochromes (CRY) act to promote photomorphogenic development and the transition from vegetative to floral development in long days (LDs). We previously proposed that one of the mechanisms by which CRY regulates light responses is via its physical interaction with COP1, a RING motif-containing E3 ligase. Under LDs, the transcription of FLOWERING LOCUS T (FT) is activated by CONSTANS (CO) in leaf, and the FT protein moves to the shoot apex to induce flowering. CO protein is degraded in darkness, whereas it is stabilized by the CRY-mediated signal. However, the mechanism underlying this process is unknown. We show in this report that CO acts genetically downstream of COP1 and CRY to regulate flowering time. In addition, COP1 physically interacts with CO and functions as an E3 ligase, ubiquitinating CO in vitro and reducing CO levels in vivo. These results suggest that COP1 acts as a repressor of flowering by promoting the ubiquitin-mediated proteolysis of CO in darkness and that CRY-mediated signal may negatively regulate COP1, thereby stabilizing CO, activating FT transcription, and inducing flowering.

[ "COP1-mediated", "ubiquitination", "of", "CONSTANS", "is", "implicated", "in", "cryptochrome", "regulation", "of", "flowering", "in", "Arabidopsis", ".", "\n", "In", "Arabidopsis", "thaliana", ",", "the", "blue", "light", "photoreceptor", "cryptochromes", "(", "CRY", ")", "act", "to", "promote", "photomorphogenic", "development", "and", "the", "transition", "from", "vegetative", "to", "floral", "development", "in", "long", "days", "(", "LDs", ")", ".", "We", "previously", "proposed", "that", "one", "of", "the", "mechanisms", "by", "which", "CRY", "regulates", "light", "responses", "is", "via", "its", "physical", "interaction", "with", "COP1", ",", "a", "RING", "motif", "-", "containing", "E3", "ligase", ".", "Under", "LDs", ",", "the", "transcription", "of", "FLOWERING", "LOCUS", "T", "(", "FT", ")", "is", "activated", "by", "CONSTANS", "(", "CO", ")", "in", "leaf", ",", "and", "the", "FT", "protein", "moves", "to", "the", "shoot", "apex", "to", "induce", "flowering", ".", "CO", "protein", "is", "degraded", "in", "darkness", ",", "whereas", "it", "is", "stabilized", "by", "the", "CRY", "-", "mediated", "signal", ".", "However", ",", "the", "mechanism", "underlying", "this", "process", "is", "unknown", ".", "We", "show", "in", "this", "report", "that", "CO", "acts", "genetically", "downstream", "of", "COP1", "and", "CRY", "to", "regulate", "flowering", "time", ".", "In", "addition", ",", "COP1", "physically", "interacts", "with", "CO", "and", "functions", "as", "an", "E3", "ligase", ",", "ubiquitinating", "CO", "in", "vitro", "and", "reducing", "CO", "levels", "in", "vivo", ".", "These", "results", "suggest", "that", "COP1", "acts", "as", "a", "repressor", "of", "flowering", "by", "promoting", "the", "ubiquitin", "-", "mediated", "proteolysis", "of", "CO", "in", "darkness", "and", "that", "CRY", "-", "mediated", "signal", "may", "negatively", "regulate", "COP1", ",", "thereby", "stabilizing", "CO", ",", "activating", "FT", "transcription", ",", "and", "inducing", "flowering", ".", "\n" ]

[ "Protein" ]

CONSTANS, COP1, FLOWERING LOCUS T, FT, CONSTANS, CO, FT, CO, CO, COP1, COP1, CO, CO, CO, COP1, ubiquitin, CO, COP1, CO, FT

305_task2

Sentence: COP1-mediated ubiquitination of CONSTANS is implicated in cryptochrome regulation of flowering in Arabidopsis. In Arabidopsis thaliana, the blue light photoreceptor cryptochromes (CRY) act to promote photomorphogenic development and the transition from vegetative to floral development in long days (LDs). We previously proposed that one of the mechanisms by which CRY regulates light responses is via its physical interaction with COP1, a RING motif-containing E3 ligase. Under LDs, the transcription of FLOWERING LOCUS T (FT) is activated by CONSTANS (CO) in leaf, and the FT protein moves to the shoot apex to induce flowering. CO protein is degraded in darkness, whereas it is stabilized by the CRY-mediated signal. However, the mechanism underlying this process is unknown. We show in this report that CO acts genetically downstream of COP1 and CRY to regulate flowering time. In addition, COP1 physically interacts with CO and functions as an E3 ligase, ubiquitinating CO in vitro and reducing CO levels in vivo. These results suggest that COP1 acts as a repressor of flowering by promoting the ubiquitin-mediated proteolysis of CO in darkness and that CRY-mediated signal may negatively regulate COP1, thereby stabilizing CO, activating FT transcription, and inducing flowering. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "B-Protein", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O" ]

COP1-mediated ubiquitination of CONSTANS is implicated in cryptochrome regulation of flowering in Arabidopsis. In Arabidopsis thaliana, the blue light photoreceptor cryptochromes (CRY) act to promote photomorphogenic development and the transition from vegetative to floral development in long days (LDs). We previously proposed that one of the mechanisms by which CRY regulates light responses is via its physical interaction with COP1, a RING motif-containing E3 ligase. Under LDs, the transcription of FLOWERING LOCUS T (FT) is activated by CONSTANS (CO) in leaf, and the FT protein moves to the shoot apex to induce flowering. CO protein is degraded in darkness, whereas it is stabilized by the CRY-mediated signal. However, the mechanism underlying this process is unknown. We show in this report that CO acts genetically downstream of COP1 and CRY to regulate flowering time. In addition, COP1 physically interacts with CO and functions as an E3 ligase, ubiquitinating CO in vitro and reducing CO levels in vivo. These results suggest that COP1 acts as a repressor of flowering by promoting the ubiquitin-mediated proteolysis of CO in darkness and that CRY-mediated signal may negatively regulate COP1, thereby stabilizing CO, activating FT transcription, and inducing flowering.

[ "COP1-mediated", "ubiquitination", "of", "CONSTANS", "is", "implicated", "in", "cryptochrome", "regulation", "of", "flowering", "in", "Arabidopsis", ".", "\n", "In", "Arabidopsis", "thaliana", ",", "the", "blue", "light", "photoreceptor", "cryptochromes", "(", "CRY", ")", "act", "to", "promote", "photomorphogenic", "development", "and", "the", "transition", "from", "vegetative", "to", "floral", "development", "in", "long", "days", "(", "LDs", ")", ".", "We", "previously", "proposed", "that", "one", "of", "the", "mechanisms", "by", "which", "CRY", "regulates", "light", "responses", "is", "via", "its", "physical", "interaction", "with", "COP1", ",", "a", "RING", "motif", "-", "containing", "E3", "ligase", ".", "Under", "LDs", ",", "the", "transcription", "of", "FLOWERING", "LOCUS", "T", "(", "FT", ")", "is", "activated", "by", "CONSTANS", "(", "CO", ")", "in", "leaf", ",", "and", "the", "FT", "protein", "moves", "to", "the", "shoot", "apex", "to", "induce", "flowering", ".", "CO", "protein", "is", "degraded", "in", "darkness", ",", "whereas", "it", "is", "stabilized", "by", "the", "CRY", "-", "mediated", "signal", ".", "However", ",", "the", "mechanism", "underlying", "this", "process", "is", "unknown", ".", "We", "show", "in", "this", "report", "that", "CO", "acts", "genetically", "downstream", "of", "COP1", "and", "CRY", "to", "regulate", "flowering", "time", ".", "In", "addition", ",", "COP1", "physically", "interacts", "with", "CO", "and", "functions", "as", "an", "E3", "ligase", ",", "ubiquitinating", "CO", "in", "vitro", "and", "reducing", "CO", "levels", "in", "vivo", ".", "These", "results", "suggest", "that", "COP1", "acts", "as", "a", "repressor", "of", "flowering", "by", "promoting", "the", "ubiquitin", "-", "mediated", "proteolysis", "of", "CO", "in", "darkness", "and", "that", "CRY", "-", "mediated", "signal", "may", "negatively", "regulate", "COP1", ",", "thereby", "stabilizing", "CO", ",", "activating", "FT", "transcription", ",", "and", "inducing", "flowering", ".", "\n" ]

[ "Protein" ]

low - fat , high - fiber diet is a Intervention_Physical, recurrence of colorectal adenomas is a Outcome_Physical, development of recurrent colorectal adenomas is a Outcome_Physical, 2079 is a Participant_Sample-size, women is a Participant_Sex, 35 is a Participant_Age, diet that was low in fat is a Intervention_Educational, high in fiber ( 18 g of dietary fiber per 1000 kcal ) is a Intervention_Educational, fruits and vegetables is a Intervention_Educational, 1905 is a Participant_Sample-size, one recurrent adenoma is a Outcome_Physical, unadjusted risk ratio is a Outcome_Physical, number of such lesions is a Outcome_Physical, recurrence of large adenomas is a Outcome_Physical, advanced adenomas is a Outcome_Physical, risk of recurrence is a Outcome_Physical

3452_task0

Sentence: Lack of effect of a low-fat , high-fiber diet on the recurrence of colorectal adenomas . Polyp Prevention Trial Study Group . BACKGROUND We tested the hypothesis that dietary intervention can inhibit the development of recurrent colorectal adenomas , which are precursors of most large-bowel cancers . METHODS We randomly assigned 2079 men and women who were 35 years of age or older and who had had one or more histologically confirmed colorectal adenomas removed within six months before randomization to one of two groups : an intervention group given intensive counseling and assigned to follow a diet that was low in fat ( 20 percent of total calories ) and high in fiber ( 18 g of dietary fiber per 1000 kcal ) and fruits and vegetables ( 3.5 servings per 1000 kcal ) , and a control group given a standard brochure on healthy eating and assigned to follow their usual diet . Subjects entered the study after undergoing complete colonoscopy and removal of adenomatous polyps ; they remained in the study for approximately four years , undergoing colonoscopy one and four years after randomization . RESULTS A total of 1905 of the randomized subjects ( 91.6 percent ) completed the study . Of the 958 subjects in the intervention group and the 947 in the control group who completed the study , 39.7 percent and 39.5 percent , respectively , had at least one recurrent adenoma ; the unadjusted risk ratio was 1.00 ( 95 percent confidence interval , 0.90 to 1.12 ) . Among subjects with recurrent adenomas , the mean ( +/-SE ) number of such lesions was 1.85+/-0.08 in the intervention group and 1.84+/-0.07 in the control group . The rate of recurrence of large adenomas ( with a maximal diameter of at least 1 cm ) and advanced adenomas ( defined as lesions that had a maximal diameter of at least 1 cm or at least 25 percent villous elements or evidence of high-grade dysplasia , including carcinoma ) did not differ significantly between the two groups . CONCLUSIONS Adopting a diet that is low in fat and high in fiber , fruits , and vegetables does not influence the risk of recurrence of colorectal adenomas . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Physical, Participant_Sex, Intervention_Educational, Participant_Age, Outcome_Physical, Participant_Sample-size

[ "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "B-Participant_Sex", "O", "O", "B-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O" ]

Lack of effect of a low-fat , high-fiber diet on the recurrence of colorectal adenomas . Polyp Prevention Trial Study Group . BACKGROUND We tested the hypothesis that dietary intervention can inhibit the development of recurrent colorectal adenomas , which are precursors of most large-bowel cancers . METHODS We randomly assigned 2079 men and women who were 35 years of age or older and who had had one or more histologically confirmed colorectal adenomas removed within six months before randomization to one of two groups : an intervention group given intensive counseling and assigned to follow a diet that was low in fat ( 20 percent of total calories ) and high in fiber ( 18 g of dietary fiber per 1000 kcal ) and fruits and vegetables ( 3.5 servings per 1000 kcal ) , and a control group given a standard brochure on healthy eating and assigned to follow their usual diet . Subjects entered the study after undergoing complete colonoscopy and removal of adenomatous polyps ; they remained in the study for approximately four years , undergoing colonoscopy one and four years after randomization . RESULTS A total of 1905 of the randomized subjects ( 91.6 percent ) completed the study . Of the 958 subjects in the intervention group and the 947 in the control group who completed the study , 39.7 percent and 39.5 percent , respectively , had at least one recurrent adenoma ; the unadjusted risk ratio was 1.00 ( 95 percent confidence interval , 0.90 to 1.12 ) . Among subjects with recurrent adenomas , the mean ( +/-SE ) number of such lesions was 1.85+/-0.08 in the intervention group and 1.84+/-0.07 in the control group . The rate of recurrence of large adenomas ( with a maximal diameter of at least 1 cm ) and advanced adenomas ( defined as lesions that had a maximal diameter of at least 1 cm or at least 25 percent villous elements or evidence of high-grade dysplasia , including carcinoma ) did not differ significantly between the two groups . CONCLUSIONS Adopting a diet that is low in fat and high in fiber , fruits , and vegetables does not influence the risk of recurrence of colorectal adenomas .

[ "Lack", "of", "effect", "of", "a", "low", "-", "fat", ",", "high", "-", "fiber", "diet", "on", "the", "recurrence", "of", "colorectal", "adenomas", ".", "Polyp", "Prevention", "Trial", "Study", "Group", ".", "BACKGROUND", "We", "tested", "the", "hypothesis", "that", "dietary", "intervention", "can", "inhibit", "the", "development", "of", "recurrent", "colorectal", "adenomas", ",", "which", "are", "precursors", "of", "most", "large", "-", "bowel", "cancers", ".", "METHODS", "We", "randomly", "assigned", "2079", "men", "and", "women", "who", "were", "35", "years", "of", "age", "or", "older", "and", "who", "had", "had", "one", "or", "more", "histologically", "confirmed", "colorectal", "adenomas", "removed", "within", "six", "months", "before", "randomization", "to", "one", "of", "two", "groups", ":", "an", "intervention", "group", "given", "intensive", "counseling", "and", "assigned", "to", "follow", "a", "diet", "that", "was", "low", "in", "fat", "(", "20", "percent", "of", "total", "calories", ")", "and", "high", "in", "fiber", "(", "18", "g", "of", "dietary", "fiber", "per", "1000", "kcal", ")", "and", "fruits", "and", "vegetables", "(", "3.5", "servings", "per", "1000", "kcal", ")", ",", "and", "a", "control", "group", "given", "a", "standard", "brochure", "on", "healthy", "eating", "and", "assigned", "to", "follow", "their", "usual", "diet", ".", "Subjects", "entered", "the", "study", "after", "undergoing", "complete", "colonoscopy", "and", "removal", "of", "adenomatous", "polyps", ";", "they", "remained", "in", "the", "study", "for", "approximately", "four", "years", ",", "undergoing", "colonoscopy", "one", "and", "four", "years", "after", "randomization", ".", "RESULTS", "A", "total", "of", "1905", "of", "the", "randomized", "subjects", "(", "91.6", "percent", ")", "completed", "the", "study", ".", "Of", "the", "958", "subjects", "in", "the", "intervention", "group", "and", "the", "947", "in", "the", "control", "group", "who", "completed", "the", "study", ",", "39.7", "percent", "and", "39.5", "percent", ",", "respectively", ",", "had", "at", "least", "one", "recurrent", "adenoma", ";", "the", "unadjusted", "risk", "ratio", "was", "1.00", "(", "95", "percent", "confidence", "interval", ",", "0.90", "to", "1.12", ")", ".", "Among", "subjects", "with", "recurrent", "adenomas", ",", "the", "mean", "(", "+", "/-SE", ")", "number", "of", "such", "lesions", "was", "1.85+/-0.08", "in", "the", "intervention", "group", "and", "1.84+/-0.07", "in", "the", "control", "group", ".", "The", "rate", "of", "recurrence", "of", "large", "adenomas", "(", "with", "a", "maximal", "diameter", "of", "at", "least", "1", "cm", ")", "and", "advanced", "adenomas", "(", "defined", "as", "lesions", "that", "had", "a", "maximal", "diameter", "of", "at", "least", "1", "cm", "or", "at", "least", "25", "percent", "villous", "elements", "or", "evidence", "of", "high", "-", "grade", "dysplasia", ",", "including", "carcinoma", ")", "did", "not", "differ", "significantly", "between", "the", "two", "groups", ".", "CONCLUSIONS", "Adopting", "a", "diet", "that", "is", "low", "in", "fat", "and", "high", "in", "fiber", ",", "fruits", ",", "and", "vegetables", "does", "not", "influence", "the", "risk", "of", "recurrence", "of", "colorectal", "adenomas", "." ]

[ "Intervention_Educational", "Outcome_Physical", "Intervention_Physical", "Participant_Condition", "Participant_Sex", "Participant_Sample-size", "Participant_Age" ]

low - fat , high - fiber diet is a Intervention_Physical, recurrence of colorectal adenomas is a Outcome_Physical, development of recurrent colorectal adenomas is a Outcome_Physical, 2079 is a Participant_Sample-size, women is a Participant_Sex, 35 is a Participant_Age, diet that was low in fat is a Intervention_Educational, high in fiber ( 18 g of dietary fiber per 1000 kcal ) is a Intervention_Educational, fruits and vegetables is a Intervention_Educational, 1905 is a Participant_Sample-size, one recurrent adenoma is a Outcome_Physical, unadjusted risk ratio is a Outcome_Physical, number of such lesions is a Outcome_Physical, recurrence of large adenomas is a Outcome_Physical, advanced adenomas is a Outcome_Physical, risk of recurrence is a Outcome_Physical

3452_task1

Sentence: Lack of effect of a low-fat , high-fiber diet on the recurrence of colorectal adenomas . Polyp Prevention Trial Study Group . BACKGROUND We tested the hypothesis that dietary intervention can inhibit the development of recurrent colorectal adenomas , which are precursors of most large-bowel cancers . METHODS We randomly assigned 2079 men and women who were 35 years of age or older and who had had one or more histologically confirmed colorectal adenomas removed within six months before randomization to one of two groups : an intervention group given intensive counseling and assigned to follow a diet that was low in fat ( 20 percent of total calories ) and high in fiber ( 18 g of dietary fiber per 1000 kcal ) and fruits and vegetables ( 3.5 servings per 1000 kcal ) , and a control group given a standard brochure on healthy eating and assigned to follow their usual diet . Subjects entered the study after undergoing complete colonoscopy and removal of adenomatous polyps ; they remained in the study for approximately four years , undergoing colonoscopy one and four years after randomization . RESULTS A total of 1905 of the randomized subjects ( 91.6 percent ) completed the study . Of the 958 subjects in the intervention group and the 947 in the control group who completed the study , 39.7 percent and 39.5 percent , respectively , had at least one recurrent adenoma ; the unadjusted risk ratio was 1.00 ( 95 percent confidence interval , 0.90 to 1.12 ) . Among subjects with recurrent adenomas , the mean ( +/-SE ) number of such lesions was 1.85+/-0.08 in the intervention group and 1.84+/-0.07 in the control group . The rate of recurrence of large adenomas ( with a maximal diameter of at least 1 cm ) and advanced adenomas ( defined as lesions that had a maximal diameter of at least 1 cm or at least 25 percent villous elements or evidence of high-grade dysplasia , including carcinoma ) did not differ significantly between the two groups . CONCLUSIONS Adopting a diet that is low in fat and high in fiber , fruits , and vegetables does not influence the risk of recurrence of colorectal adenomas . Instructions: please typing these entity words according to sentence: low - fat , high - fiber diet, recurrence of colorectal adenomas, development of recurrent colorectal adenomas, 2079, women, 35, diet that was low in fat, high in fiber ( 18 g of dietary fiber per 1000 kcal ), fruits and vegetables, 1905, one recurrent adenoma, unadjusted risk ratio, number of such lesions, recurrence of large adenomas, advanced adenomas, risk of recurrence Options: Intervention_Physical, Participant_Sex, Intervention_Educational, Participant_Age, Outcome_Physical, Participant_Sample-size

[ "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "B-Participant_Sex", "O", "O", "B-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O" ]

Lack of effect of a low-fat , high-fiber diet on the recurrence of colorectal adenomas . Polyp Prevention Trial Study Group . BACKGROUND We tested the hypothesis that dietary intervention can inhibit the development of recurrent colorectal adenomas , which are precursors of most large-bowel cancers . METHODS We randomly assigned 2079 men and women who were 35 years of age or older and who had had one or more histologically confirmed colorectal adenomas removed within six months before randomization to one of two groups : an intervention group given intensive counseling and assigned to follow a diet that was low in fat ( 20 percent of total calories ) and high in fiber ( 18 g of dietary fiber per 1000 kcal ) and fruits and vegetables ( 3.5 servings per 1000 kcal ) , and a control group given a standard brochure on healthy eating and assigned to follow their usual diet . Subjects entered the study after undergoing complete colonoscopy and removal of adenomatous polyps ; they remained in the study for approximately four years , undergoing colonoscopy one and four years after randomization . RESULTS A total of 1905 of the randomized subjects ( 91.6 percent ) completed the study . Of the 958 subjects in the intervention group and the 947 in the control group who completed the study , 39.7 percent and 39.5 percent , respectively , had at least one recurrent adenoma ; the unadjusted risk ratio was 1.00 ( 95 percent confidence interval , 0.90 to 1.12 ) . Among subjects with recurrent adenomas , the mean ( +/-SE ) number of such lesions was 1.85+/-0.08 in the intervention group and 1.84+/-0.07 in the control group . The rate of recurrence of large adenomas ( with a maximal diameter of at least 1 cm ) and advanced adenomas ( defined as lesions that had a maximal diameter of at least 1 cm or at least 25 percent villous elements or evidence of high-grade dysplasia , including carcinoma ) did not differ significantly between the two groups . CONCLUSIONS Adopting a diet that is low in fat and high in fiber , fruits , and vegetables does not influence the risk of recurrence of colorectal adenomas .

[ "Lack", "of", "effect", "of", "a", "low", "-", "fat", ",", "high", "-", "fiber", "diet", "on", "the", "recurrence", "of", "colorectal", "adenomas", ".", "Polyp", "Prevention", "Trial", "Study", "Group", ".", "BACKGROUND", "We", "tested", "the", "hypothesis", "that", "dietary", "intervention", "can", "inhibit", "the", "development", "of", "recurrent", "colorectal", "adenomas", ",", "which", "are", "precursors", "of", "most", "large", "-", "bowel", "cancers", ".", "METHODS", "We", "randomly", "assigned", "2079", "men", "and", "women", "who", "were", "35", "years", "of", "age", "or", "older", "and", "who", "had", "had", "one", "or", "more", "histologically", "confirmed", "colorectal", "adenomas", "removed", "within", "six", "months", "before", "randomization", "to", "one", "of", "two", "groups", ":", "an", "intervention", "group", "given", "intensive", "counseling", "and", "assigned", "to", "follow", "a", "diet", "that", "was", "low", "in", "fat", "(", "20", "percent", "of", "total", "calories", ")", "and", "high", "in", "fiber", "(", "18", "g", "of", "dietary", "fiber", "per", "1000", "kcal", ")", "and", "fruits", "and", "vegetables", "(", "3.5", "servings", "per", "1000", "kcal", ")", ",", "and", "a", "control", "group", "given", "a", "standard", "brochure", "on", "healthy", "eating", "and", "assigned", "to", "follow", "their", "usual", "diet", ".", "Subjects", "entered", "the", "study", "after", "undergoing", "complete", "colonoscopy", "and", "removal", "of", "adenomatous", "polyps", ";", "they", "remained", "in", "the", "study", "for", "approximately", "four", "years", ",", "undergoing", "colonoscopy", "one", "and", "four", "years", "after", "randomization", ".", "RESULTS", "A", "total", "of", "1905", "of", "the", "randomized", "subjects", "(", "91.6", "percent", ")", "completed", "the", "study", ".", "Of", "the", "958", "subjects", "in", "the", "intervention", "group", "and", "the", "947", "in", "the", "control", "group", "who", "completed", "the", "study", ",", "39.7", "percent", "and", "39.5", "percent", ",", "respectively", ",", "had", "at", "least", "one", "recurrent", "adenoma", ";", "the", "unadjusted", "risk", "ratio", "was", "1.00", "(", "95", "percent", "confidence", "interval", ",", "0.90", "to", "1.12", ")", ".", "Among", "subjects", "with", "recurrent", "adenomas", ",", "the", "mean", "(", "+", "/-SE", ")", "number", "of", "such", "lesions", "was", "1.85+/-0.08", "in", "the", "intervention", "group", "and", "1.84+/-0.07", "in", "the", "control", "group", ".", "The", "rate", "of", "recurrence", "of", "large", "adenomas", "(", "with", "a", "maximal", "diameter", "of", "at", "least", "1", "cm", ")", "and", "advanced", "adenomas", "(", "defined", "as", "lesions", "that", "had", "a", "maximal", "diameter", "of", "at", "least", "1", "cm", "or", "at", "least", "25", "percent", "villous", "elements", "or", "evidence", "of", "high", "-", "grade", "dysplasia", ",", "including", "carcinoma", ")", "did", "not", "differ", "significantly", "between", "the", "two", "groups", ".", "CONCLUSIONS", "Adopting", "a", "diet", "that", "is", "low", "in", "fat", "and", "high", "in", "fiber", ",", "fruits", ",", "and", "vegetables", "does", "not", "influence", "the", "risk", "of", "recurrence", "of", "colorectal", "adenomas", "." ]

[ "Intervention_Educational", "Outcome_Physical", "Intervention_Physical", "Participant_Condition", "Participant_Sex", "Participant_Sample-size", "Participant_Age" ]

low - fat , high - fiber diet, recurrence of colorectal adenomas, development of recurrent colorectal adenomas, 2079, women, 35, diet that was low in fat, high in fiber ( 18 g of dietary fiber per 1000 kcal ), fruits and vegetables, 1905, one recurrent adenoma, unadjusted risk ratio, number of such lesions, recurrence of large adenomas, advanced adenomas, risk of recurrence

3452_task2

Sentence: Lack of effect of a low-fat , high-fiber diet on the recurrence of colorectal adenomas . Polyp Prevention Trial Study Group . BACKGROUND We tested the hypothesis that dietary intervention can inhibit the development of recurrent colorectal adenomas , which are precursors of most large-bowel cancers . METHODS We randomly assigned 2079 men and women who were 35 years of age or older and who had had one or more histologically confirmed colorectal adenomas removed within six months before randomization to one of two groups : an intervention group given intensive counseling and assigned to follow a diet that was low in fat ( 20 percent of total calories ) and high in fiber ( 18 g of dietary fiber per 1000 kcal ) and fruits and vegetables ( 3.5 servings per 1000 kcal ) , and a control group given a standard brochure on healthy eating and assigned to follow their usual diet . Subjects entered the study after undergoing complete colonoscopy and removal of adenomatous polyps ; they remained in the study for approximately four years , undergoing colonoscopy one and four years after randomization . RESULTS A total of 1905 of the randomized subjects ( 91.6 percent ) completed the study . Of the 958 subjects in the intervention group and the 947 in the control group who completed the study , 39.7 percent and 39.5 percent , respectively , had at least one recurrent adenoma ; the unadjusted risk ratio was 1.00 ( 95 percent confidence interval , 0.90 to 1.12 ) . Among subjects with recurrent adenomas , the mean ( +/-SE ) number of such lesions was 1.85+/-0.08 in the intervention group and 1.84+/-0.07 in the control group . The rate of recurrence of large adenomas ( with a maximal diameter of at least 1 cm ) and advanced adenomas ( defined as lesions that had a maximal diameter of at least 1 cm or at least 25 percent villous elements or evidence of high-grade dysplasia , including carcinoma ) did not differ significantly between the two groups . CONCLUSIONS Adopting a diet that is low in fat and high in fiber , fruits , and vegetables does not influence the risk of recurrence of colorectal adenomas . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "B-Participant_Sex", "O", "O", "B-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O" ]

Lack of effect of a low-fat , high-fiber diet on the recurrence of colorectal adenomas . Polyp Prevention Trial Study Group . BACKGROUND We tested the hypothesis that dietary intervention can inhibit the development of recurrent colorectal adenomas , which are precursors of most large-bowel cancers . METHODS We randomly assigned 2079 men and women who were 35 years of age or older and who had had one or more histologically confirmed colorectal adenomas removed within six months before randomization to one of two groups : an intervention group given intensive counseling and assigned to follow a diet that was low in fat ( 20 percent of total calories ) and high in fiber ( 18 g of dietary fiber per 1000 kcal ) and fruits and vegetables ( 3.5 servings per 1000 kcal ) , and a control group given a standard brochure on healthy eating and assigned to follow their usual diet . Subjects entered the study after undergoing complete colonoscopy and removal of adenomatous polyps ; they remained in the study for approximately four years , undergoing colonoscopy one and four years after randomization . RESULTS A total of 1905 of the randomized subjects ( 91.6 percent ) completed the study . Of the 958 subjects in the intervention group and the 947 in the control group who completed the study , 39.7 percent and 39.5 percent , respectively , had at least one recurrent adenoma ; the unadjusted risk ratio was 1.00 ( 95 percent confidence interval , 0.90 to 1.12 ) . Among subjects with recurrent adenomas , the mean ( +/-SE ) number of such lesions was 1.85+/-0.08 in the intervention group and 1.84+/-0.07 in the control group . The rate of recurrence of large adenomas ( with a maximal diameter of at least 1 cm ) and advanced adenomas ( defined as lesions that had a maximal diameter of at least 1 cm or at least 25 percent villous elements or evidence of high-grade dysplasia , including carcinoma ) did not differ significantly between the two groups . CONCLUSIONS Adopting a diet that is low in fat and high in fiber , fruits , and vegetables does not influence the risk of recurrence of colorectal adenomas .

[ "Lack", "of", "effect", "of", "a", "low", "-", "fat", ",", "high", "-", "fiber", "diet", "on", "the", "recurrence", "of", "colorectal", "adenomas", ".", "Polyp", "Prevention", "Trial", "Study", "Group", ".", "BACKGROUND", "We", "tested", "the", "hypothesis", "that", "dietary", "intervention", "can", "inhibit", "the", "development", "of", "recurrent", "colorectal", "adenomas", ",", "which", "are", "precursors", "of", "most", "large", "-", "bowel", "cancers", ".", "METHODS", "We", "randomly", "assigned", "2079", "men", "and", "women", "who", "were", "35", "years", "of", "age", "or", "older", "and", "who", "had", "had", "one", "or", "more", "histologically", "confirmed", "colorectal", "adenomas", "removed", "within", "six", "months", "before", "randomization", "to", "one", "of", "two", "groups", ":", "an", "intervention", "group", "given", "intensive", "counseling", "and", "assigned", "to", "follow", "a", "diet", "that", "was", "low", "in", "fat", "(", "20", "percent", "of", "total", "calories", ")", "and", "high", "in", "fiber", "(", "18", "g", "of", "dietary", "fiber", "per", "1000", "kcal", ")", "and", "fruits", "and", "vegetables", "(", "3.5", "servings", "per", "1000", "kcal", ")", ",", "and", "a", "control", "group", "given", "a", "standard", "brochure", "on", "healthy", "eating", "and", "assigned", "to", "follow", "their", "usual", "diet", ".", "Subjects", "entered", "the", "study", "after", "undergoing", "complete", "colonoscopy", "and", "removal", "of", "adenomatous", "polyps", ";", "they", "remained", "in", "the", "study", "for", "approximately", "four", "years", ",", "undergoing", "colonoscopy", "one", "and", "four", "years", "after", "randomization", ".", "RESULTS", "A", "total", "of", "1905", "of", "the", "randomized", "subjects", "(", "91.6", "percent", ")", "completed", "the", "study", ".", "Of", "the", "958", "subjects", "in", "the", "intervention", "group", "and", "the", "947", "in", "the", "control", "group", "who", "completed", "the", "study", ",", "39.7", "percent", "and", "39.5", "percent", ",", "respectively", ",", "had", "at", "least", "one", "recurrent", "adenoma", ";", "the", "unadjusted", "risk", "ratio", "was", "1.00", "(", "95", "percent", "confidence", "interval", ",", "0.90", "to", "1.12", ")", ".", "Among", "subjects", "with", "recurrent", "adenomas", ",", "the", "mean", "(", "+", "/-SE", ")", "number", "of", "such", "lesions", "was", "1.85+/-0.08", "in", "the", "intervention", "group", "and", "1.84+/-0.07", "in", "the", "control", "group", ".", "The", "rate", "of", "recurrence", "of", "large", "adenomas", "(", "with", "a", "maximal", "diameter", "of", "at", "least", "1", "cm", ")", "and", "advanced", "adenomas", "(", "defined", "as", "lesions", "that", "had", "a", "maximal", "diameter", "of", "at", "least", "1", "cm", "or", "at", "least", "25", "percent", "villous", "elements", "or", "evidence", "of", "high", "-", "grade", "dysplasia", ",", "including", "carcinoma", ")", "did", "not", "differ", "significantly", "between", "the", "two", "groups", ".", "CONCLUSIONS", "Adopting", "a", "diet", "that", "is", "low", "in", "fat", "and", "high", "in", "fiber", ",", "fruits", ",", "and", "vegetables", "does", "not", "influence", "the", "risk", "of", "recurrence", "of", "colorectal", "adenomas", "." ]

[ "Intervention_Educational", "Outcome_Physical", "Intervention_Physical", "Participant_Condition", "Participant_Sex", "Participant_Sample-size", "Participant_Age" ]

Psychiatrie is an umlsterm, Psychotherapie is an umlsterm, Therapieverfahren is an umlsterm, Praxis is an umlsterm, Methode is an umlsterm

DerNervenarzt.00710173.ger.abstr_task0

Sentence: In der Psychiatrie und Psychotherapie finden weiterhin viele Therapieverfahren Anwendung ohne dass ein empirischer Nachweis ihrer Wirksamkeit vorliegt . Die aus dem angloamerikanischen Sprachraum stammende " Evidence-based Medicine " bietet ein Konzept , medizinische Entscheidungen auf der Basis der besten zz . Verfuegbaren externen Evidenz in Verbindung mit der individuellen klinischen Erfahrung zu treffen . In diesem Beitrag werden zunaechst Beispiele einer Non-evidence-based Psychiatry " " aufgezeigt , ein klinisches Beispiel soll das Konzept einer Evidence-based Psychiatry " " vorstellen , am Ende schliesslich steht die Betrachtung ihrer Anwendung , Grenzen und Moeglichkeiten in der Praxis . Zum einen wird der Stellenwert dieser Methode fuer den klinisch taetigen Psychiater und Psychotherapeuten dargestellt . Zum anderen werden moegliche Konsequenzen diskutiert . Diese ergeben sich fuer Aufbereitung und Bereitstellung der Evidenz in Form von Datenbanken und systematischen Uebersichtsarbeiten und in der Notwendigkeit von Umbauprozessen fuer die einzelne Institution wie auch fuer das Gesundheitssystem als Ganzes . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

In der Psychiatrie und Psychotherapie finden weiterhin viele Therapieverfahren Anwendung ohne dass ein empirischer Nachweis ihrer Wirksamkeit vorliegt . Die aus dem angloamerikanischen Sprachraum stammende " Evidence-based Medicine " bietet ein Konzept , medizinische Entscheidungen auf der Basis der besten zz . Verfuegbaren externen Evidenz in Verbindung mit der individuellen klinischen Erfahrung zu treffen . In diesem Beitrag werden zunaechst Beispiele einer Non-evidence-based Psychiatry " " aufgezeigt , ein klinisches Beispiel soll das Konzept einer Evidence-based Psychiatry " " vorstellen , am Ende schliesslich steht die Betrachtung ihrer Anwendung , Grenzen und Moeglichkeiten in der Praxis . Zum einen wird der Stellenwert dieser Methode fuer den klinisch taetigen Psychiater und Psychotherapeuten dargestellt . Zum anderen werden moegliche Konsequenzen diskutiert . Diese ergeben sich fuer Aufbereitung und Bereitstellung der Evidenz in Form von Datenbanken und systematischen Uebersichtsarbeiten und in der Notwendigkeit von Umbauprozessen fuer die einzelne Institution wie auch fuer das Gesundheitssystem als Ganzes .

[ "In", "der", "Psychiatrie", "und", "Psychotherapie", "finden", "weiterhin", "viele", "Therapieverfahren", "Anwendung", "ohne", "dass", "ein", "empirischer", "Nachweis", "ihrer", "Wirksamkeit", "vorliegt", ".", "Die", "aus", "dem", "angloamerikanischen", "Sprachraum", "stammende", "\"", "Evidence", "-", "based", "Medicine", "\"", "bietet", "ein", "Konzept", ",", "medizinische", "Entscheidungen", "auf", "der", "Basis", "der", "besten", "zz", ".", "Verfuegbaren", "externen", "Evidenz", "in", "Verbindung", "mit", "der", "individuellen", "klinischen", "Erfahrung", "zu", "treffen", ".", "In", "diesem", "Beitrag", "werden", "zunaechst", "Beispiele", "einer", "Non", "-", "evidence", "-", "based", "Psychiatry", "\"", "\"", "aufgezeigt", ",", "ein", "klinisches", "Beispiel", "soll", "das", "Konzept", "einer", "Evidence", "-", "based", "Psychiatry", "\"", "\"", "vorstellen", ",", "am", "Ende", "schliesslich", "steht", "die", "Betrachtung", "ihrer", "Anwendung", ",", "Grenzen", "und", "Moeglichkeiten", "in", "der", "Praxis", ".", "Zum", "einen", "wird", "der", "Stellenwert", "dieser", "Methode", "fuer", "den", "klinisch", "taetigen", "Psychiater", "und", "Psychotherapeuten", "dargestellt", ".", "Zum", "anderen", "werden", "moegliche", "Konsequenzen", "diskutiert", ".", "Diese", "ergeben", "sich", "fuer", "Aufbereitung", "und", "Bereitstellung", "der", "Evidenz", "in", "Form", "von", "Datenbanken", "und", "systematischen", "Uebersichtsarbeiten", "und", "in", "der", "Notwendigkeit", "von", "Umbauprozessen", "fuer", "die", "einzelne", "Institution", "wie", "auch", "fuer", "das", "Gesundheitssystem", "als", "Ganzes", "." ]

[ "umlsterm" ]

Psychiatrie is an umlsterm, Psychotherapie is an umlsterm, Therapieverfahren is an umlsterm, Praxis is an umlsterm, Methode is an umlsterm

DerNervenarzt.00710173.ger.abstr_task1

Sentence: In der Psychiatrie und Psychotherapie finden weiterhin viele Therapieverfahren Anwendung ohne dass ein empirischer Nachweis ihrer Wirksamkeit vorliegt . Die aus dem angloamerikanischen Sprachraum stammende " Evidence-based Medicine " bietet ein Konzept , medizinische Entscheidungen auf der Basis der besten zz . Verfuegbaren externen Evidenz in Verbindung mit der individuellen klinischen Erfahrung zu treffen . In diesem Beitrag werden zunaechst Beispiele einer Non-evidence-based Psychiatry " " aufgezeigt , ein klinisches Beispiel soll das Konzept einer Evidence-based Psychiatry " " vorstellen , am Ende schliesslich steht die Betrachtung ihrer Anwendung , Grenzen und Moeglichkeiten in der Praxis . Zum einen wird der Stellenwert dieser Methode fuer den klinisch taetigen Psychiater und Psychotherapeuten dargestellt . Zum anderen werden moegliche Konsequenzen diskutiert . Diese ergeben sich fuer Aufbereitung und Bereitstellung der Evidenz in Form von Datenbanken und systematischen Uebersichtsarbeiten und in der Notwendigkeit von Umbauprozessen fuer die einzelne Institution wie auch fuer das Gesundheitssystem als Ganzes . Instructions: please typing these entity words according to sentence: Psychiatrie, Psychotherapie, Therapieverfahren, Praxis, Methode Options: umlsterm

[ "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

In der Psychiatrie und Psychotherapie finden weiterhin viele Therapieverfahren Anwendung ohne dass ein empirischer Nachweis ihrer Wirksamkeit vorliegt . Die aus dem angloamerikanischen Sprachraum stammende " Evidence-based Medicine " bietet ein Konzept , medizinische Entscheidungen auf der Basis der besten zz . Verfuegbaren externen Evidenz in Verbindung mit der individuellen klinischen Erfahrung zu treffen . In diesem Beitrag werden zunaechst Beispiele einer Non-evidence-based Psychiatry " " aufgezeigt , ein klinisches Beispiel soll das Konzept einer Evidence-based Psychiatry " " vorstellen , am Ende schliesslich steht die Betrachtung ihrer Anwendung , Grenzen und Moeglichkeiten in der Praxis . Zum einen wird der Stellenwert dieser Methode fuer den klinisch taetigen Psychiater und Psychotherapeuten dargestellt . Zum anderen werden moegliche Konsequenzen diskutiert . Diese ergeben sich fuer Aufbereitung und Bereitstellung der Evidenz in Form von Datenbanken und systematischen Uebersichtsarbeiten und in der Notwendigkeit von Umbauprozessen fuer die einzelne Institution wie auch fuer das Gesundheitssystem als Ganzes .

[ "In", "der", "Psychiatrie", "und", "Psychotherapie", "finden", "weiterhin", "viele", "Therapieverfahren", "Anwendung", "ohne", "dass", "ein", "empirischer", "Nachweis", "ihrer", "Wirksamkeit", "vorliegt", ".", "Die", "aus", "dem", "angloamerikanischen", "Sprachraum", "stammende", "\"", "Evidence", "-", "based", "Medicine", "\"", "bietet", "ein", "Konzept", ",", "medizinische", "Entscheidungen", "auf", "der", "Basis", "der", "besten", "zz", ".", "Verfuegbaren", "externen", "Evidenz", "in", "Verbindung", "mit", "der", "individuellen", "klinischen", "Erfahrung", "zu", "treffen", ".", "In", "diesem", "Beitrag", "werden", "zunaechst", "Beispiele", "einer", "Non", "-", "evidence", "-", "based", "Psychiatry", "\"", "\"", "aufgezeigt", ",", "ein", "klinisches", "Beispiel", "soll", "das", "Konzept", "einer", "Evidence", "-", "based", "Psychiatry", "\"", "\"", "vorstellen", ",", "am", "Ende", "schliesslich", "steht", "die", "Betrachtung", "ihrer", "Anwendung", ",", "Grenzen", "und", "Moeglichkeiten", "in", "der", "Praxis", ".", "Zum", "einen", "wird", "der", "Stellenwert", "dieser", "Methode", "fuer", "den", "klinisch", "taetigen", "Psychiater", "und", "Psychotherapeuten", "dargestellt", ".", "Zum", "anderen", "werden", "moegliche", "Konsequenzen", "diskutiert", ".", "Diese", "ergeben", "sich", "fuer", "Aufbereitung", "und", "Bereitstellung", "der", "Evidenz", "in", "Form", "von", "Datenbanken", "und", "systematischen", "Uebersichtsarbeiten", "und", "in", "der", "Notwendigkeit", "von", "Umbauprozessen", "fuer", "die", "einzelne", "Institution", "wie", "auch", "fuer", "das", "Gesundheitssystem", "als", "Ganzes", "." ]

[ "umlsterm" ]

Psychiatrie, Psychotherapie, Therapieverfahren, Praxis, Methode

DerNervenarzt.00710173.ger.abstr_task2

Sentence: In der Psychiatrie und Psychotherapie finden weiterhin viele Therapieverfahren Anwendung ohne dass ein empirischer Nachweis ihrer Wirksamkeit vorliegt . Die aus dem angloamerikanischen Sprachraum stammende " Evidence-based Medicine " bietet ein Konzept , medizinische Entscheidungen auf der Basis der besten zz . Verfuegbaren externen Evidenz in Verbindung mit der individuellen klinischen Erfahrung zu treffen . In diesem Beitrag werden zunaechst Beispiele einer Non-evidence-based Psychiatry " " aufgezeigt , ein klinisches Beispiel soll das Konzept einer Evidence-based Psychiatry " " vorstellen , am Ende schliesslich steht die Betrachtung ihrer Anwendung , Grenzen und Moeglichkeiten in der Praxis . Zum einen wird der Stellenwert dieser Methode fuer den klinisch taetigen Psychiater und Psychotherapeuten dargestellt . Zum anderen werden moegliche Konsequenzen diskutiert . Diese ergeben sich fuer Aufbereitung und Bereitstellung der Evidenz in Form von Datenbanken und systematischen Uebersichtsarbeiten und in der Notwendigkeit von Umbauprozessen fuer die einzelne Institution wie auch fuer das Gesundheitssystem als Ganzes . Instructions: please extract entity words from the input sentence

[ "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

In der Psychiatrie und Psychotherapie finden weiterhin viele Therapieverfahren Anwendung ohne dass ein empirischer Nachweis ihrer Wirksamkeit vorliegt . Die aus dem angloamerikanischen Sprachraum stammende " Evidence-based Medicine " bietet ein Konzept , medizinische Entscheidungen auf der Basis der besten zz . Verfuegbaren externen Evidenz in Verbindung mit der individuellen klinischen Erfahrung zu treffen . In diesem Beitrag werden zunaechst Beispiele einer Non-evidence-based Psychiatry " " aufgezeigt , ein klinisches Beispiel soll das Konzept einer Evidence-based Psychiatry " " vorstellen , am Ende schliesslich steht die Betrachtung ihrer Anwendung , Grenzen und Moeglichkeiten in der Praxis . Zum einen wird der Stellenwert dieser Methode fuer den klinisch taetigen Psychiater und Psychotherapeuten dargestellt . Zum anderen werden moegliche Konsequenzen diskutiert . Diese ergeben sich fuer Aufbereitung und Bereitstellung der Evidenz in Form von Datenbanken und systematischen Uebersichtsarbeiten und in der Notwendigkeit von Umbauprozessen fuer die einzelne Institution wie auch fuer das Gesundheitssystem als Ganzes .

[ "In", "der", "Psychiatrie", "und", "Psychotherapie", "finden", "weiterhin", "viele", "Therapieverfahren", "Anwendung", "ohne", "dass", "ein", "empirischer", "Nachweis", "ihrer", "Wirksamkeit", "vorliegt", ".", "Die", "aus", "dem", "angloamerikanischen", "Sprachraum", "stammende", "\"", "Evidence", "-", "based", "Medicine", "\"", "bietet", "ein", "Konzept", ",", "medizinische", "Entscheidungen", "auf", "der", "Basis", "der", "besten", "zz", ".", "Verfuegbaren", "externen", "Evidenz", "in", "Verbindung", "mit", "der", "individuellen", "klinischen", "Erfahrung", "zu", "treffen", ".", "In", "diesem", "Beitrag", "werden", "zunaechst", "Beispiele", "einer", "Non", "-", "evidence", "-", "based", "Psychiatry", "\"", "\"", "aufgezeigt", ",", "ein", "klinisches", "Beispiel", "soll", "das", "Konzept", "einer", "Evidence", "-", "based", "Psychiatry", "\"", "\"", "vorstellen", ",", "am", "Ende", "schliesslich", "steht", "die", "Betrachtung", "ihrer", "Anwendung", ",", "Grenzen", "und", "Moeglichkeiten", "in", "der", "Praxis", ".", "Zum", "einen", "wird", "der", "Stellenwert", "dieser", "Methode", "fuer", "den", "klinisch", "taetigen", "Psychiater", "und", "Psychotherapeuten", "dargestellt", ".", "Zum", "anderen", "werden", "moegliche", "Konsequenzen", "diskutiert", ".", "Diese", "ergeben", "sich", "fuer", "Aufbereitung", "und", "Bereitstellung", "der", "Evidenz", "in", "Form", "von", "Datenbanken", "und", "systematischen", "Uebersichtsarbeiten", "und", "in", "der", "Notwendigkeit", "von", "Umbauprozessen", "fuer", "die", "einzelne", "Institution", "wie", "auch", "fuer", "das", "Gesundheitssystem", "als", "Ganzes", "." ]

[ "umlsterm" ]

neurofibromatosis is a MORFOLOGIA_NEOPLASIA, neurofibromas múltiples is a MORFOLOGIA_NEOPLASIA, cáncer is a MORFOLOGIA_NEOPLASIA, neurofibromatosis is a MORFOLOGIA_NEOPLASIA, tumoración is a MORFOLOGIA_NEOPLASIA, neurofibroma is a MORFOLOGIA_NEOPLASIA, sarcoma pleomorfico de alto grado is a MORFOLOGIA_NEOPLASIA, tumor maligno de la vaina nerviosa periférica is a MORFOLOGIA_NEOPLASIA, TMVNP is a MORFOLOGIA_NEOPLASIA, tumoración is a MORFOLOGIA_NEOPLASIA, neurofibromas múltiples is a MORFOLOGIA_NEOPLASIA, neurofibromas is a MORFOLOGIA_NEOPLASIA, TMVNP is a MORFOLOGIA_NEOPLASIA, tumoración is a MORFOLOGIA_NEOPLASIA, extensión local y a distancia is a MORFOLOGIA_NEOPLASIA, tumor is a MORFOLOGIA_NEOPLASIA, tumoración is a MORFOLOGIA_NEOPLASIA, TMVNP con diferenciación rabdomiosarcomatosa is a MORFOLOGIA_NEOPLASIA, tumor de tritón is a MORFOLOGIA_NEOPLASIA, nódulo pulmonar is a MORFOLOGIA_NEOPLASIA, metástasis única con tumor is a MORFOLOGIA_NEOPLASIA, TMVNP is a MORFOLOGIA_NEOPLASIA

679_task0

Sentence: Anamnesis Se trata de una mujer de 45 años de edad, como único antecedente patológico destaca una neurofibromatosis tipo 1 diagnosticada en la infancia en forma de neurofibromas múltiples subcutáneos, efélides axilares y manchas cafe-au-lait; no había habido afectación neurológica, ósea ni ocular. Su madre fue diagnosticada de un cáncer de colon a la edad de 67 años, pero no había antecedentes familiares de neurofibromatosis. Exploración física La paciente acudió inicialmente a su Hospital de referencia en Enero de 2013 con clínica de más de un año de evolución consistente en dolor y en la aparición de una tumoración en la escápula derecha. Se realizaron estudios de imagen con ecografía de tejidos blandos donde se apreciaba una masa solida de 45 mm con vascularización y características típicas de neurofibroma y posteriormente una resonancia de escapula derecha que describió una gran masa de 15 cm con necrosis central y signos de vascularización de "características benignas", con lo cual se procedió a realizar una resección marginal en de la lesión en diciembre de 2013. Desgraciadamente, el estudio patológico informó de un sarcoma pleomorfico de alto grado, compatible con un tumor maligno de la vaina nerviosa periférica (TMVNP). Con los datos de anatomía patológica y la cirugía no compartimental sin criterios oncológicos realizada, se procede a remitir a la paciente a nuestro hospital. En ese momento la paciente se encontraba bien, aunque refería rápida reaparición del dolor en el hombro tras la cirugía; en la exploración se aprecia una tumoración fija y gomosa en la escápula derecha. Se apreciaban múltiples neurofibromas múltiples subcutáneos, efélides axilares y manchas cafe-au-lait. Pruebas complementarias » PET-TAC de extensión en febrero de 2014: muestra una masa de partes blandas de 6,2 x 2,8 cm con intenso hipermetabolismo patológico (SUVmáx 20,2 g/ml) que erosiona la escápula derecha, sugestivo de comportamiento agresivo, además se observan múltiples nódulos en la piel, todos ametabólicos, que corresponden a neurofibromas cutáneos. Diagnóstico Expuesto el caso con estos datos en la comisión de tumores, se consideró que la paciente era candidata a tratamiento QT neoadyuvante (para disminuir la extensión de la lesión y con ello la morbilidad de la cirugía) seguida de cirugía con criterios radicales y radioterapia adyuvante. La paciente es incluida en el ensayo clínico GEIS 25 de QT neoadyuvante adaptada al histiotipo (epirrubicina-ifosfamida frente a ifosfamida-VP16 en el caso de TMVNP). La paciente recibe tres ciclos de ifosfamida-VP16 entre marzo y mayo de 2014, con evidente respuesta clínica desde el primer ciclo. La evaluación tras tres ciclos mostró una reducción muy significativa, mayor del 90 % de la tumoración, que se limita prácticamente a la fosa infraespinosa, con zonas avasculares en su interior sugestivas de necrosis, y ausencia de extensión local y a distancia. Vista la excelente respuesta parcial mayor tras la QT, se procede a la planificación de la cirugía con criterios oncológicos por parte del equipo de tumores óseos, realizando escapulectomía subtotal a través del cuello de la escápula manteniendo junto a la pieza extirpada el subescapular, supraespinoso, infraespinoso y redondo menor en junio de 2014. El resultado patológico de la pieza quirúrgica muestra una celularidad mayoritariamente pleomórfica con otras áreas de morfología fusocelular pura y estroma amplio mixoide, zonas de necrosis con células espumosas y células inflamatorias mononucleadas en aproximadamente el 50% del volumen total del tumor. En el estudio inmunohistoquímico las células pleomórficas expresan diferenciación muscular estriada (vimentina + desmina + calponina + miogenina + nuclear, MYOD1 + nuclear). Las fusiformes son focalmente positivas para MyoD1, CD34, y pS100. EMA, beta-catenina, AE1/3, actina. Los bordes de resección estaban libres de tumoración. Todos estos hallazgos eran compatibles con un TMVNP con diferenciación rabdomiosarcomatosa (tumor de tritón). Se complementa el tratamiento con RT externa adyuvante para una dosis total de 66 Gy. Tratamiento QTT neoadyuvante seguida de cirugía con criterios radicales y RT adyuvante. Evolución La paciente inicia seguimiento en nuestras consultas. En enero de 2015, seis meses tras la cirugía radical, se aprecia en la TC un nódulo pulmonar posterobasal derecho que mide aproximadamente 20 mm de diámetro. La PET-TC confirma la presencia de un nódulo redondeado de 26 x 26 x 29 mm hipermetabólico (SUVmáx 5,8 g/ml) en la base del LID, que ha crecido con respecto al estudio TC previa y que no aparecía en el estudio inicial. La paciente permanecía clínicamente asintomática. Dada la presencia de metástasis única con tumor primario controlado, remitimos a la paciente a cirugía torácica para valoración de metastasectomía pulmonar. Se procedió a una cirugía exploradora en febrero de 2015, apreciándose un nódulo de gran tamaño ocupando prácticamente toda la pirámide basal con adenopatías en cisura perivasculares; se practica una lobectomía inferior derecha y una disección ganglionar paratraqueal derecha, localizando además otra adenopatía precava (también resecada). La biopsia confirma la proliferación celular mesenquimal atípica bien delimitada, no encapsulada, formando haces entrecruzados en alternancia con zonas de necrosis y degeneración de aspecto mixoide, además una población celular mayoritaria conformada por elementos fusiformes, sugestiva de TMVNP, aunque no se observa diferenciación rabdomiosarcomatosa. Los bordes quirúrgicos y las adenopatías están libres. Se considera que no hay criterios para tratamiento con QT pseudoadyuvante y la paciente sigue controles en nuestras consultas sin evidencia de enfermedad activa en el momento actual. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: MORFOLOGIA_NEOPLASIA

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Anamnesis Se trata de una mujer de 45 años de edad, como único antecedente patológico destaca una neurofibromatosis tipo 1 diagnosticada en la infancia en forma de neurofibromas múltiples subcutáneos, efélides axilares y manchas cafe-au-lait; no había habido afectación neurológica, ósea ni ocular. Su madre fue diagnosticada de un cáncer de colon a la edad de 67 años, pero no había antecedentes familiares de neurofibromatosis. Exploración física La paciente acudió inicialmente a su Hospital de referencia en Enero de 2013 con clínica de más de un año de evolución consistente en dolor y en la aparición de una tumoración en la escápula derecha. Se realizaron estudios de imagen con ecografía de tejidos blandos donde se apreciaba una masa solida de 45 mm con vascularización y características típicas de neurofibroma y posteriormente una resonancia de escapula derecha que describió una gran masa de 15 cm con necrosis central y signos de vascularización de "características benignas", con lo cual se procedió a realizar una resección marginal en de la lesión en diciembre de 2013. Desgraciadamente, el estudio patológico informó de un sarcoma pleomorfico de alto grado, compatible con un tumor maligno de la vaina nerviosa periférica (TMVNP). Con los datos de anatomía patológica y la cirugía no compartimental sin criterios oncológicos realizada, se procede a remitir a la paciente a nuestro hospital. En ese momento la paciente se encontraba bien, aunque refería rápida reaparición del dolor en el hombro tras la cirugía; en la exploración se aprecia una tumoración fija y gomosa en la escápula derecha. Se apreciaban múltiples neurofibromas múltiples subcutáneos, efélides axilares y manchas cafe-au-lait. Pruebas complementarias » PET-TAC de extensión en febrero de 2014: muestra una masa de partes blandas de 6,2 x 2,8 cm con intenso hipermetabolismo patológico (SUVmáx 20,2 g/ml) que erosiona la escápula derecha, sugestivo de comportamiento agresivo, además se observan múltiples nódulos en la piel, todos ametabólicos, que corresponden a neurofibromas cutáneos. Diagnóstico Expuesto el caso con estos datos en la comisión de tumores, se consideró que la paciente era candidata a tratamiento QT neoadyuvante (para disminuir la extensión de la lesión y con ello la morbilidad de la cirugía) seguida de cirugía con criterios radicales y radioterapia adyuvante. La paciente es incluida en el ensayo clínico GEIS 25 de QT neoadyuvante adaptada al histiotipo (epirrubicina-ifosfamida frente a ifosfamida-VP16 en el caso de TMVNP). La paciente recibe tres ciclos de ifosfamida-VP16 entre marzo y mayo de 2014, con evidente respuesta clínica desde el primer ciclo. La evaluación tras tres ciclos mostró una reducción muy significativa, mayor del 90 % de la tumoración, que se limita prácticamente a la fosa infraespinosa, con zonas avasculares en su interior sugestivas de necrosis, y ausencia de extensión local y a distancia. Vista la excelente respuesta parcial mayor tras la QT, se procede a la planificación de la cirugía con criterios oncológicos por parte del equipo de tumores óseos, realizando escapulectomía subtotal a través del cuello de la escápula manteniendo junto a la pieza extirpada el subescapular, supraespinoso, infraespinoso y redondo menor en junio de 2014. El resultado patológico de la pieza quirúrgica muestra una celularidad mayoritariamente pleomórfica con otras áreas de morfología fusocelular pura y estroma amplio mixoide, zonas de necrosis con células espumosas y células inflamatorias mononucleadas en aproximadamente el 50% del volumen total del tumor. En el estudio inmunohistoquímico las células pleomórficas expresan diferenciación muscular estriada (vimentina + desmina + calponina + miogenina + nuclear, MYOD1 + nuclear). Las fusiformes son focalmente positivas para MyoD1, CD34, y pS100. EMA, beta-catenina, AE1/3, actina. Los bordes de resección estaban libres de tumoración. Todos estos hallazgos eran compatibles con un TMVNP con diferenciación rabdomiosarcomatosa (tumor de tritón). Se complementa el tratamiento con RT externa adyuvante para una dosis total de 66 Gy. Tratamiento QTT neoadyuvante seguida de cirugía con criterios radicales y RT adyuvante. Evolución La paciente inicia seguimiento en nuestras consultas. En enero de 2015, seis meses tras la cirugía radical, se aprecia en la TC un nódulo pulmonar posterobasal derecho que mide aproximadamente 20 mm de diámetro. La PET-TC confirma la presencia de un nódulo redondeado de 26 x 26 x 29 mm hipermetabólico (SUVmáx 5,8 g/ml) en la base del LID, que ha crecido con respecto al estudio TC previa y que no aparecía en el estudio inicial. La paciente permanecía clínicamente asintomática. Dada la presencia de metástasis única con tumor primario controlado, remitimos a la paciente a cirugía torácica para valoración de metastasectomía pulmonar. Se procedió a una cirugía exploradora en febrero de 2015, apreciándose un nódulo de gran tamaño ocupando prácticamente toda la pirámide basal con adenopatías en cisura perivasculares; se practica una lobectomía inferior derecha y una disección ganglionar paratraqueal derecha, localizando además otra adenopatía precava (también resecada). La biopsia confirma la proliferación celular mesenquimal atípica bien delimitada, no encapsulada, formando haces entrecruzados en alternancia con zonas de necrosis y degeneración de aspecto mixoide, además una población celular mayoritaria conformada por elementos fusiformes, sugestiva de TMVNP, aunque no se observa diferenciación rabdomiosarcomatosa. Los bordes quirúrgicos y las adenopatías están libres. Se considera que no hay criterios para tratamiento con QT pseudoadyuvante y la paciente sigue controles en nuestras consultas sin evidencia de enfermedad activa en el momento actual.

[ "Anamnesis", "\n", "Se", "trata", "de", "una", "mujer", "de", "45", "años", "de", "edad", ",", "como", "único", "antecedente", "patológico", "destaca", "una", "neurofibromatosis", "tipo", "1", "diagnosticada", "en", "la", "infancia", "en", "forma", "de", "neurofibromas", "múltiples", "subcutáneos", ",", "efélides", "axilares", "y", "manchas", "cafe", "-", "au", "-", "lait", ";", "no", "había", "habido", "afectación", "neurológica", ",", "ósea", "ni", "ocular", ".", "Su", "madre", "fue", "diagnosticada", "de", "un", "cáncer", "de", "colon", "a", "la", "edad", "de", "67", "años", ",", "pero", "no", "había", "antecedentes", "familiares", "de", "neurofibromatosis", ".", "\n\n", "Exploración", "física", "\n", "La", "paciente", "acudió", "inicialmente", "a", "su", "Hospital", "de", "referencia", "en", "Enero", "de", "2013", "con", "clínica", "de", "más", "de", "un", "año", "de", "evolución", "consistente", "en", "dolor", "y", "en", "la", "aparición", "de", "una", "tumoración", "en", "la", "escápula", "derecha", ".", "Se", "realizaron", "estudios", "de", "imagen", "con", "ecografía", "de", "tejidos", "blandos", "donde", "se", "apreciaba", "una", "masa", "solida", "de", "45", "mm", "con", "vascularización", "y", "características", "típicas", "de", "neurofibroma", "y", "posteriormente", "una", "resonancia", "de", "escapula", "derecha", "que", "describió", "una", "gran", "masa", "de", "15", "cm", "con", "necrosis", "central", "y", "signos", "de", "vascularización", "de", "\"", "características", "benignas", "\"", ",", "con", "lo", "cual", "se", "procedió", "a", "realizar", "una", "resección", "marginal", "en", "de", "la", "lesión", "en", "diciembre", "de", "2013", ".", "Desgraciadamente", ",", "el", "estudio", "patológico", "informó", "de", "un", "sarcoma", "pleomorfico", "de", "alto", "grado", ",", "compatible", "con", "un", "tumor", "maligno", "de", "la", "vaina", "nerviosa", "periférica", "(", "TMVNP", ")", ".", "\n\n", "Con", "los", "datos", "de", "anatomía", "patológica", "y", "la", "cirugía", "no", "compartimental", "sin", "criterios", "oncológicos", "realizada", ",", "se", "procede", "a", "remitir", "a", "la", "paciente", "a", "nuestro", "hospital", ".", "En", "ese", "momento", "la", "paciente", "se", "encontraba", "bien", ",", "aunque", "refería", "rápida", "reaparición", "del", "dolor", "en", "el", "hombro", "tras", "la", "cirugía", ";", "en", "la", "exploración", "se", "aprecia", "una", "tumoración", "fija", "y", "gomosa", "en", "la", "escápula", "derecha", ".", "Se", "apreciaban", "múltiples", "neurofibromas", "múltiples", "subcutáneos", ",", "efélides", "axilares", "y", "manchas", "cafe", "-", "au", "-", "lait", ".", "\n\n", "Pruebas", "complementarias", "\n", "»", "PET", "-", "TAC", "de", "extensión", "en", "febrero", "de", "2014", ":", "muestra", "una", "masa", "de", "partes", "blandas", "de", "6,2", "x", "2,8", "cm", "con", "intenso", "hipermetabolismo", "patológico", "(", "SUVmáx", "20,2", "g", "/", "ml", ")", "que", "erosiona", "la", "escápula", "derecha", ",", "sugestivo", "de", "comportamiento", "agresivo", ",", "además", "se", "observan", "múltiples", "nódulos", "en", "la", "piel", ",", "todos", "ametabólicos", ",", "que", "corresponden", "a", "neurofibromas", "cutáneos", ".", "\n\n", "Diagnóstico", "\n", "Expuesto", "el", "caso", "con", "estos", "datos", "en", "la", "comisión", "de", "tumores", ",", "se", "consideró", "que", "la", "paciente", "era", "candidata", "a", "tratamiento", "QT", "neoadyuvante", "(", "para", "disminuir", "la", "extensión", "de", "la", "lesión", "y", "con", "ello", "la", "morbilidad", "de", "la", "cirugía", ")", "seguida", "de", "cirugía", "con", "criterios", "radicales", "y", "radioterapia", "adyuvante", ".", "\n\n", "La", "paciente", "es", "incluida", "en", "el", "ensayo", "clínico", "GEIS", "25", "de", "QT", "neoadyuvante", "adaptada", "al", "histiotipo", "(", "epirrubicina", "-", "ifosfamida", "frente", "a", "ifosfamida", "-", "VP16", "en", "el", "caso", "de", "TMVNP", ")", ".", "La", "paciente", "recibe", "tres", "ciclos", "de", "ifosfamida", "-", "VP16", "entre", "marzo", "y", "mayo", "de", "2014", ",", "con", "evidente", "respuesta", "clínica", "desde", "el", "primer", "ciclo", ".", "La", "evaluación", "tras", "tres", "ciclos", "mostró", "una", "reducción", "muy", "significativa", ",", "mayor", "del", "90", "%", "de", "la", "tumoración", ",", "que", "se", "limita", "prácticamente", "a", "la", "fosa", "infraespinosa", ",", "con", "zonas", "avasculares", "en", "su", "interior", "sugestivas", "de", "necrosis", ",", "y", "ausencia", "de", "extensión", "local", "y", "a", "distancia", ".", "\n\n", "Vista", "la", "excelente", "respuesta", "parcial", "mayor", "tras", "la", "QT", ",", "se", "procede", "a", "la", "planificación", "de", "la", "cirugía", "con", "criterios", "oncológicos", "por", "parte", "del", "equipo", "de", "tumores", "óseos", ",", "realizando", "escapulectomía", "subtotal", "a", "través", "del", "cuello", "de", "la", "escápula", "manteniendo", "junto", "a", "la", "pieza", "extirpada", "el", "subescapular", ",", "supraespinoso", ",", "infraespinoso", "y", "redondo", "menor", "en", "junio", "de", "2014", ".", "\n\n", "El", "resultado", "patológico", "de", "la", "pieza", "quirúrgica", "muestra", "una", "celularidad", "mayoritariamente", "pleomórfica", "con", "otras", "áreas", "de", "morfología", "fusocelular", "pura", "y", "estroma", "amplio", "mixoide", ",", "zonas", "de", "necrosis", "con", "células", "espumosas", "y", "células", "inflamatorias", "mononucleadas", "en", "aproximadamente", "el", "50", "%", "del", "volumen", "total", "del", "tumor", ".", "En", "el", "estudio", "inmunohistoquímico", "las", "células", "pleomórficas", "expresan", "diferenciación", "muscular", "estriada", "(", "vimentina", "+", "desmina", "+", "calponina", "+", "miogenina", "+", "nuclear", ",", "MYOD1", "+", "nuclear", ")", ".", "Las", "fusiformes", "son", "focalmente", "positivas", "para", "MyoD1", ",", "CD34", ",", "y", "pS100", ".", "EMA", ",", "beta", "-", "catenina", ",", "AE1/3", ",", "actina", ".", "Los", "bordes", "de", "resección", "estaban", "libres", "de", "tumoración", ".", "Todos", "estos", "hallazgos", "eran", "compatibles", "con", "un", "TMVNP", "con", "diferenciación", "rabdomiosarcomatosa", "(", "tumor", "de", "tritón", ")", ".", "\n\n", "Se", "complementa", "el", "tratamiento", "con", "RT", "externa", "adyuvante", "para", "una", "dosis", "total", "de", "66", "Gy", ".", "\n\n", "Tratamiento", "\n", "QTT", "neoadyuvante", "seguida", "de", "cirugía", "con", "criterios", "radicales", "y", "RT", "adyuvante", ".", "\n\n", "Evolución", "\n", "La", "paciente", "inicia", "seguimiento", "en", "nuestras", "consultas", ".", "En", "enero", "de", "2015", ",", "seis", "meses", "tras", "la", "cirugía", "radical", ",", "se", "aprecia", "en", "la", "TC", "un", "nódulo", "pulmonar", "posterobasal", "derecho", "que", "mide", "aproximadamente", "20", "mm", "de", "diámetro", ".", "La", "PET", "-", "TC", "confirma", "la", "presencia", "de", "un", "nódulo", "redondeado", "de", "26", "x", "26", "x", "29", "mm", "hipermetabólico", "(", "SUVmáx", "5,8", "g", "/", "ml", ")", "en", "la", "base", "del", "LID", ",", "que", "ha", "crecido", "con", "respecto", "al", "estudio", "TC", "previa", "y", "que", "no", "aparecía", "en", "el", "estudio", "inicial", ".", "La", "paciente", "permanecía", "clínicamente", "asintomática", ".", "\n\n", "Dada", "la", "presencia", "de", "metástasis", "única", "con", "tumor", "primario", "controlado", ",", "remitimos", "a", "la", "paciente", "a", "cirugía", "torácica", "para", "valoración", "de", "metastasectomía", "pulmonar", ".", "\n\n", "Se", "procedió", "a", "una", "cirugía", "exploradora", "en", "febrero", "de", "2015", ",", "apreciándose", "un", "nódulo", "de", "gran", "tamaño", "ocupando", "prácticamente", "toda", "la", "pirámide", "basal", "con", "adenopatías", "en", "cisura", "perivasculares", ";", "se", "practica", "una", "lobectomía", "inferior", "derecha", "y", "una", "disección", "ganglionar", "paratraqueal", "derecha", ",", "localizando", "además", "otra", "adenopatía", "precava", "(", "también", "resecada", ")", ".", "La", "biopsia", "confirma", "la", "proliferación", "celular", "mesenquimal", "atípica", "bien", "delimitada", ",", "no", "encapsulada", ",", "formando", "haces", "entrecruzados", "en", "alternancia", "con", "zonas", "de", "necrosis", "y", "degeneración", "de", "aspecto", "mixoide", ",", "además", "una", "población", "celular", "mayoritaria", "conformada", "por", "elementos", "fusiformes", ",", "sugestiva", "de", "TMVNP", ",", "aunque", "no", "se", "observa", "diferenciación", "rabdomiosarcomatosa", ".", "Los", "bordes", "quirúrgicos", "y", "las", "adenopatías", "están", "libres", ".", "\n\n", "Se", "considera", "que", "no", "hay", "criterios", "para", "tratamiento", "con", "QT", "pseudoadyuvante", "y", "la", "paciente", "sigue", "controles", "en", "nuestras", "consultas", "sin", "evidencia", "de", "enfermedad", "activa", "en", "el", "momento", "actual", "." ]

[ "MORFOLOGIA_NEOPLASIA" ]

neurofibromatosis is a MORFOLOGIA_NEOPLASIA, neurofibromas múltiples is a MORFOLOGIA_NEOPLASIA, cáncer is a MORFOLOGIA_NEOPLASIA, neurofibromatosis is a MORFOLOGIA_NEOPLASIA, tumoración is a MORFOLOGIA_NEOPLASIA, neurofibroma is a MORFOLOGIA_NEOPLASIA, sarcoma pleomorfico de alto grado is a MORFOLOGIA_NEOPLASIA, tumor maligno de la vaina nerviosa periférica is a MORFOLOGIA_NEOPLASIA, TMVNP is a MORFOLOGIA_NEOPLASIA, tumoración is a MORFOLOGIA_NEOPLASIA, neurofibromas múltiples is a MORFOLOGIA_NEOPLASIA, neurofibromas is a MORFOLOGIA_NEOPLASIA, TMVNP is a MORFOLOGIA_NEOPLASIA, tumoración is a MORFOLOGIA_NEOPLASIA, extensión local y a distancia is a MORFOLOGIA_NEOPLASIA, tumor is a MORFOLOGIA_NEOPLASIA, tumoración is a MORFOLOGIA_NEOPLASIA, TMVNP con diferenciación rabdomiosarcomatosa is a MORFOLOGIA_NEOPLASIA, tumor de tritón is a MORFOLOGIA_NEOPLASIA, nódulo pulmonar is a MORFOLOGIA_NEOPLASIA, metástasis única con tumor is a MORFOLOGIA_NEOPLASIA, TMVNP is a MORFOLOGIA_NEOPLASIA

679_task1

Sentence: Anamnesis Se trata de una mujer de 45 años de edad, como único antecedente patológico destaca una neurofibromatosis tipo 1 diagnosticada en la infancia en forma de neurofibromas múltiples subcutáneos, efélides axilares y manchas cafe-au-lait; no había habido afectación neurológica, ósea ni ocular. Su madre fue diagnosticada de un cáncer de colon a la edad de 67 años, pero no había antecedentes familiares de neurofibromatosis. Exploración física La paciente acudió inicialmente a su Hospital de referencia en Enero de 2013 con clínica de más de un año de evolución consistente en dolor y en la aparición de una tumoración en la escápula derecha. Se realizaron estudios de imagen con ecografía de tejidos blandos donde se apreciaba una masa solida de 45 mm con vascularización y características típicas de neurofibroma y posteriormente una resonancia de escapula derecha que describió una gran masa de 15 cm con necrosis central y signos de vascularización de "características benignas", con lo cual se procedió a realizar una resección marginal en de la lesión en diciembre de 2013. Desgraciadamente, el estudio patológico informó de un sarcoma pleomorfico de alto grado, compatible con un tumor maligno de la vaina nerviosa periférica (TMVNP). Con los datos de anatomía patológica y la cirugía no compartimental sin criterios oncológicos realizada, se procede a remitir a la paciente a nuestro hospital. En ese momento la paciente se encontraba bien, aunque refería rápida reaparición del dolor en el hombro tras la cirugía; en la exploración se aprecia una tumoración fija y gomosa en la escápula derecha. Se apreciaban múltiples neurofibromas múltiples subcutáneos, efélides axilares y manchas cafe-au-lait. Pruebas complementarias » PET-TAC de extensión en febrero de 2014: muestra una masa de partes blandas de 6,2 x 2,8 cm con intenso hipermetabolismo patológico (SUVmáx 20,2 g/ml) que erosiona la escápula derecha, sugestivo de comportamiento agresivo, además se observan múltiples nódulos en la piel, todos ametabólicos, que corresponden a neurofibromas cutáneos. Diagnóstico Expuesto el caso con estos datos en la comisión de tumores, se consideró que la paciente era candidata a tratamiento QT neoadyuvante (para disminuir la extensión de la lesión y con ello la morbilidad de la cirugía) seguida de cirugía con criterios radicales y radioterapia adyuvante. La paciente es incluida en el ensayo clínico GEIS 25 de QT neoadyuvante adaptada al histiotipo (epirrubicina-ifosfamida frente a ifosfamida-VP16 en el caso de TMVNP). La paciente recibe tres ciclos de ifosfamida-VP16 entre marzo y mayo de 2014, con evidente respuesta clínica desde el primer ciclo. La evaluación tras tres ciclos mostró una reducción muy significativa, mayor del 90 % de la tumoración, que se limita prácticamente a la fosa infraespinosa, con zonas avasculares en su interior sugestivas de necrosis, y ausencia de extensión local y a distancia. Vista la excelente respuesta parcial mayor tras la QT, se procede a la planificación de la cirugía con criterios oncológicos por parte del equipo de tumores óseos, realizando escapulectomía subtotal a través del cuello de la escápula manteniendo junto a la pieza extirpada el subescapular, supraespinoso, infraespinoso y redondo menor en junio de 2014. El resultado patológico de la pieza quirúrgica muestra una celularidad mayoritariamente pleomórfica con otras áreas de morfología fusocelular pura y estroma amplio mixoide, zonas de necrosis con células espumosas y células inflamatorias mononucleadas en aproximadamente el 50% del volumen total del tumor. En el estudio inmunohistoquímico las células pleomórficas expresan diferenciación muscular estriada (vimentina + desmina + calponina + miogenina + nuclear, MYOD1 + nuclear). Las fusiformes son focalmente positivas para MyoD1, CD34, y pS100. EMA, beta-catenina, AE1/3, actina. Los bordes de resección estaban libres de tumoración. Todos estos hallazgos eran compatibles con un TMVNP con diferenciación rabdomiosarcomatosa (tumor de tritón). Se complementa el tratamiento con RT externa adyuvante para una dosis total de 66 Gy. Tratamiento QTT neoadyuvante seguida de cirugía con criterios radicales y RT adyuvante. Evolución La paciente inicia seguimiento en nuestras consultas. En enero de 2015, seis meses tras la cirugía radical, se aprecia en la TC un nódulo pulmonar posterobasal derecho que mide aproximadamente 20 mm de diámetro. La PET-TC confirma la presencia de un nódulo redondeado de 26 x 26 x 29 mm hipermetabólico (SUVmáx 5,8 g/ml) en la base del LID, que ha crecido con respecto al estudio TC previa y que no aparecía en el estudio inicial. La paciente permanecía clínicamente asintomática. Dada la presencia de metástasis única con tumor primario controlado, remitimos a la paciente a cirugía torácica para valoración de metastasectomía pulmonar. Se procedió a una cirugía exploradora en febrero de 2015, apreciándose un nódulo de gran tamaño ocupando prácticamente toda la pirámide basal con adenopatías en cisura perivasculares; se practica una lobectomía inferior derecha y una disección ganglionar paratraqueal derecha, localizando además otra adenopatía precava (también resecada). La biopsia confirma la proliferación celular mesenquimal atípica bien delimitada, no encapsulada, formando haces entrecruzados en alternancia con zonas de necrosis y degeneración de aspecto mixoide, además una población celular mayoritaria conformada por elementos fusiformes, sugestiva de TMVNP, aunque no se observa diferenciación rabdomiosarcomatosa. Los bordes quirúrgicos y las adenopatías están libres. Se considera que no hay criterios para tratamiento con QT pseudoadyuvante y la paciente sigue controles en nuestras consultas sin evidencia de enfermedad activa en el momento actual. Instructions: please typing these entity words according to sentence: neurofibromatosis, neurofibromas múltiples, cáncer, neurofibromatosis, tumoración, neurofibroma, sarcoma pleomorfico de alto grado, tumor maligno de la vaina nerviosa periférica, TMVNP, tumoración, neurofibromas múltiples, neurofibromas, TMVNP, tumoración, extensión local y a distancia, tumor, tumoración, TMVNP con diferenciación rabdomiosarcomatosa, tumor de tritón, nódulo pulmonar, metástasis única con tumor, TMVNP Options: MORFOLOGIA_NEOPLASIA

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Anamnesis Se trata de una mujer de 45 años de edad, como único antecedente patológico destaca una neurofibromatosis tipo 1 diagnosticada en la infancia en forma de neurofibromas múltiples subcutáneos, efélides axilares y manchas cafe-au-lait; no había habido afectación neurológica, ósea ni ocular. Su madre fue diagnosticada de un cáncer de colon a la edad de 67 años, pero no había antecedentes familiares de neurofibromatosis. Exploración física La paciente acudió inicialmente a su Hospital de referencia en Enero de 2013 con clínica de más de un año de evolución consistente en dolor y en la aparición de una tumoración en la escápula derecha. Se realizaron estudios de imagen con ecografía de tejidos blandos donde se apreciaba una masa solida de 45 mm con vascularización y características típicas de neurofibroma y posteriormente una resonancia de escapula derecha que describió una gran masa de 15 cm con necrosis central y signos de vascularización de "características benignas", con lo cual se procedió a realizar una resección marginal en de la lesión en diciembre de 2013. Desgraciadamente, el estudio patológico informó de un sarcoma pleomorfico de alto grado, compatible con un tumor maligno de la vaina nerviosa periférica (TMVNP). Con los datos de anatomía patológica y la cirugía no compartimental sin criterios oncológicos realizada, se procede a remitir a la paciente a nuestro hospital. En ese momento la paciente se encontraba bien, aunque refería rápida reaparición del dolor en el hombro tras la cirugía; en la exploración se aprecia una tumoración fija y gomosa en la escápula derecha. Se apreciaban múltiples neurofibromas múltiples subcutáneos, efélides axilares y manchas cafe-au-lait. Pruebas complementarias » PET-TAC de extensión en febrero de 2014: muestra una masa de partes blandas de 6,2 x 2,8 cm con intenso hipermetabolismo patológico (SUVmáx 20,2 g/ml) que erosiona la escápula derecha, sugestivo de comportamiento agresivo, además se observan múltiples nódulos en la piel, todos ametabólicos, que corresponden a neurofibromas cutáneos. Diagnóstico Expuesto el caso con estos datos en la comisión de tumores, se consideró que la paciente era candidata a tratamiento QT neoadyuvante (para disminuir la extensión de la lesión y con ello la morbilidad de la cirugía) seguida de cirugía con criterios radicales y radioterapia adyuvante. La paciente es incluida en el ensayo clínico GEIS 25 de QT neoadyuvante adaptada al histiotipo (epirrubicina-ifosfamida frente a ifosfamida-VP16 en el caso de TMVNP). La paciente recibe tres ciclos de ifosfamida-VP16 entre marzo y mayo de 2014, con evidente respuesta clínica desde el primer ciclo. La evaluación tras tres ciclos mostró una reducción muy significativa, mayor del 90 % de la tumoración, que se limita prácticamente a la fosa infraespinosa, con zonas avasculares en su interior sugestivas de necrosis, y ausencia de extensión local y a distancia. Vista la excelente respuesta parcial mayor tras la QT, se procede a la planificación de la cirugía con criterios oncológicos por parte del equipo de tumores óseos, realizando escapulectomía subtotal a través del cuello de la escápula manteniendo junto a la pieza extirpada el subescapular, supraespinoso, infraespinoso y redondo menor en junio de 2014. El resultado patológico de la pieza quirúrgica muestra una celularidad mayoritariamente pleomórfica con otras áreas de morfología fusocelular pura y estroma amplio mixoide, zonas de necrosis con células espumosas y células inflamatorias mononucleadas en aproximadamente el 50% del volumen total del tumor. En el estudio inmunohistoquímico las células pleomórficas expresan diferenciación muscular estriada (vimentina + desmina + calponina + miogenina + nuclear, MYOD1 + nuclear). Las fusiformes son focalmente positivas para MyoD1, CD34, y pS100. EMA, beta-catenina, AE1/3, actina. Los bordes de resección estaban libres de tumoración. Todos estos hallazgos eran compatibles con un TMVNP con diferenciación rabdomiosarcomatosa (tumor de tritón). Se complementa el tratamiento con RT externa adyuvante para una dosis total de 66 Gy. Tratamiento QTT neoadyuvante seguida de cirugía con criterios radicales y RT adyuvante. Evolución La paciente inicia seguimiento en nuestras consultas. En enero de 2015, seis meses tras la cirugía radical, se aprecia en la TC un nódulo pulmonar posterobasal derecho que mide aproximadamente 20 mm de diámetro. La PET-TC confirma la presencia de un nódulo redondeado de 26 x 26 x 29 mm hipermetabólico (SUVmáx 5,8 g/ml) en la base del LID, que ha crecido con respecto al estudio TC previa y que no aparecía en el estudio inicial. La paciente permanecía clínicamente asintomática. Dada la presencia de metástasis única con tumor primario controlado, remitimos a la paciente a cirugía torácica para valoración de metastasectomía pulmonar. Se procedió a una cirugía exploradora en febrero de 2015, apreciándose un nódulo de gran tamaño ocupando prácticamente toda la pirámide basal con adenopatías en cisura perivasculares; se practica una lobectomía inferior derecha y una disección ganglionar paratraqueal derecha, localizando además otra adenopatía precava (también resecada). La biopsia confirma la proliferación celular mesenquimal atípica bien delimitada, no encapsulada, formando haces entrecruzados en alternancia con zonas de necrosis y degeneración de aspecto mixoide, además una población celular mayoritaria conformada por elementos fusiformes, sugestiva de TMVNP, aunque no se observa diferenciación rabdomiosarcomatosa. Los bordes quirúrgicos y las adenopatías están libres. Se considera que no hay criterios para tratamiento con QT pseudoadyuvante y la paciente sigue controles en nuestras consultas sin evidencia de enfermedad activa en el momento actual.

[ "Anamnesis", "\n", "Se", "trata", "de", "una", "mujer", "de", "45", "años", "de", "edad", ",", "como", "único", "antecedente", "patológico", "destaca", "una", "neurofibromatosis", "tipo", "1", "diagnosticada", "en", "la", "infancia", "en", "forma", "de", "neurofibromas", "múltiples", "subcutáneos", ",", "efélides", "axilares", "y", "manchas", "cafe", "-", "au", "-", "lait", ";", "no", "había", "habido", "afectación", "neurológica", ",", "ósea", "ni", "ocular", ".", "Su", "madre", "fue", "diagnosticada", "de", "un", "cáncer", "de", "colon", "a", "la", "edad", "de", "67", "años", ",", "pero", "no", "había", "antecedentes", "familiares", "de", "neurofibromatosis", ".", "\n\n", "Exploración", "física", "\n", "La", "paciente", "acudió", "inicialmente", "a", "su", "Hospital", "de", "referencia", "en", "Enero", "de", "2013", "con", "clínica", "de", "más", "de", "un", "año", "de", "evolución", "consistente", "en", "dolor", "y", "en", "la", "aparición", "de", "una", "tumoración", "en", "la", "escápula", "derecha", ".", "Se", "realizaron", "estudios", "de", "imagen", "con", "ecografía", "de", "tejidos", "blandos", "donde", "se", "apreciaba", "una", "masa", "solida", "de", "45", "mm", "con", "vascularización", "y", "características", "típicas", "de", "neurofibroma", "y", "posteriormente", "una", "resonancia", "de", "escapula", "derecha", "que", "describió", "una", "gran", "masa", "de", "15", "cm", "con", "necrosis", "central", "y", "signos", "de", "vascularización", "de", "\"", "características", "benignas", "\"", ",", "con", "lo", "cual", "se", "procedió", "a", "realizar", "una", "resección", "marginal", "en", "de", "la", "lesión", "en", "diciembre", "de", "2013", ".", "Desgraciadamente", ",", "el", "estudio", "patológico", "informó", "de", "un", "sarcoma", "pleomorfico", "de", "alto", "grado", ",", "compatible", "con", "un", "tumor", "maligno", "de", "la", "vaina", "nerviosa", "periférica", "(", "TMVNP", ")", ".", "\n\n", "Con", "los", "datos", "de", "anatomía", "patológica", "y", "la", "cirugía", "no", "compartimental", "sin", "criterios", "oncológicos", "realizada", ",", "se", "procede", "a", "remitir", "a", "la", "paciente", "a", "nuestro", "hospital", ".", "En", "ese", "momento", "la", "paciente", "se", "encontraba", "bien", ",", "aunque", "refería", "rápida", "reaparición", "del", "dolor", "en", "el", "hombro", "tras", "la", "cirugía", ";", "en", "la", "exploración", "se", "aprecia", "una", "tumoración", "fija", "y", "gomosa", "en", "la", "escápula", "derecha", ".", "Se", "apreciaban", "múltiples", "neurofibromas", "múltiples", "subcutáneos", ",", "efélides", "axilares", "y", "manchas", "cafe", "-", "au", "-", "lait", ".", "\n\n", "Pruebas", "complementarias", "\n", "»", "PET", "-", "TAC", "de", "extensión", "en", "febrero", "de", "2014", ":", "muestra", "una", "masa", "de", "partes", "blandas", "de", "6,2", "x", "2,8", "cm", "con", "intenso", "hipermetabolismo", "patológico", "(", "SUVmáx", "20,2", "g", "/", "ml", ")", "que", "erosiona", "la", "escápula", "derecha", ",", "sugestivo", "de", "comportamiento", "agresivo", ",", "además", "se", "observan", "múltiples", "nódulos", "en", "la", "piel", ",", "todos", "ametabólicos", ",", "que", "corresponden", "a", "neurofibromas", "cutáneos", ".", "\n\n", "Diagnóstico", "\n", "Expuesto", "el", "caso", "con", "estos", "datos", "en", "la", "comisión", "de", "tumores", ",", "se", "consideró", "que", "la", "paciente", "era", "candidata", "a", "tratamiento", "QT", "neoadyuvante", "(", "para", "disminuir", "la", "extensión", "de", "la", "lesión", "y", "con", "ello", "la", "morbilidad", "de", "la", "cirugía", ")", "seguida", "de", "cirugía", "con", "criterios", "radicales", "y", "radioterapia", "adyuvante", ".", "\n\n", "La", "paciente", "es", "incluida", "en", "el", "ensayo", "clínico", "GEIS", "25", "de", "QT", "neoadyuvante", "adaptada", "al", "histiotipo", "(", "epirrubicina", "-", "ifosfamida", "frente", "a", "ifosfamida", "-", "VP16", "en", "el", "caso", "de", "TMVNP", ")", ".", "La", "paciente", "recibe", "tres", "ciclos", "de", "ifosfamida", "-", "VP16", "entre", "marzo", "y", "mayo", "de", "2014", ",", "con", "evidente", "respuesta", "clínica", "desde", "el", "primer", "ciclo", ".", "La", "evaluación", "tras", "tres", "ciclos", "mostró", "una", "reducción", "muy", "significativa", ",", "mayor", "del", "90", "%", "de", "la", "tumoración", ",", "que", "se", "limita", "prácticamente", "a", "la", "fosa", "infraespinosa", ",", "con", "zonas", "avasculares", "en", "su", "interior", "sugestivas", "de", "necrosis", ",", "y", "ausencia", "de", "extensión", "local", "y", "a", "distancia", ".", "\n\n", "Vista", "la", "excelente", "respuesta", "parcial", "mayor", "tras", "la", "QT", ",", "se", "procede", "a", "la", "planificación", "de", "la", "cirugía", "con", "criterios", "oncológicos", "por", "parte", "del", "equipo", "de", "tumores", "óseos", ",", "realizando", "escapulectomía", "subtotal", "a", "través", "del", "cuello", "de", "la", "escápula", "manteniendo", "junto", "a", "la", "pieza", "extirpada", "el", "subescapular", ",", "supraespinoso", ",", "infraespinoso", "y", "redondo", "menor", "en", "junio", "de", "2014", ".", "\n\n", "El", "resultado", "patológico", "de", "la", "pieza", "quirúrgica", "muestra", "una", "celularidad", "mayoritariamente", "pleomórfica", "con", "otras", "áreas", "de", "morfología", "fusocelular", "pura", "y", "estroma", "amplio", "mixoide", ",", "zonas", "de", "necrosis", "con", "células", "espumosas", "y", "células", "inflamatorias", "mononucleadas", "en", "aproximadamente", "el", "50", "%", "del", "volumen", "total", "del", "tumor", ".", "En", "el", "estudio", "inmunohistoquímico", "las", "células", "pleomórficas", "expresan", "diferenciación", "muscular", "estriada", "(", "vimentina", "+", "desmina", "+", "calponina", "+", "miogenina", "+", "nuclear", ",", "MYOD1", "+", "nuclear", ")", ".", "Las", "fusiformes", "son", "focalmente", "positivas", "para", "MyoD1", ",", "CD34", ",", "y", "pS100", ".", "EMA", ",", "beta", "-", "catenina", ",", "AE1/3", ",", "actina", ".", "Los", "bordes", "de", "resección", "estaban", "libres", "de", "tumoración", ".", "Todos", "estos", "hallazgos", "eran", "compatibles", "con", "un", "TMVNP", "con", "diferenciación", "rabdomiosarcomatosa", "(", "tumor", "de", "tritón", ")", ".", "\n\n", "Se", "complementa", "el", "tratamiento", "con", "RT", "externa", "adyuvante", "para", "una", "dosis", "total", "de", "66", "Gy", ".", "\n\n", "Tratamiento", "\n", "QTT", "neoadyuvante", "seguida", "de", "cirugía", "con", "criterios", "radicales", "y", "RT", "adyuvante", ".", "\n\n", "Evolución", "\n", "La", "paciente", "inicia", "seguimiento", "en", "nuestras", "consultas", ".", "En", "enero", "de", "2015", ",", "seis", "meses", "tras", "la", "cirugía", "radical", ",", "se", "aprecia", "en", "la", "TC", "un", "nódulo", "pulmonar", "posterobasal", "derecho", "que", "mide", "aproximadamente", "20", "mm", "de", "diámetro", ".", "La", "PET", "-", "TC", "confirma", "la", "presencia", "de", "un", "nódulo", "redondeado", "de", "26", "x", "26", "x", "29", "mm", "hipermetabólico", "(", "SUVmáx", "5,8", "g", "/", "ml", ")", "en", "la", "base", "del", "LID", ",", "que", "ha", "crecido", "con", "respecto", "al", "estudio", "TC", "previa", "y", "que", "no", "aparecía", "en", "el", "estudio", "inicial", ".", "La", "paciente", "permanecía", "clínicamente", "asintomática", ".", "\n\n", "Dada", "la", "presencia", "de", "metástasis", "única", "con", "tumor", "primario", "controlado", ",", "remitimos", "a", "la", "paciente", "a", "cirugía", "torácica", "para", "valoración", "de", "metastasectomía", "pulmonar", ".", "\n\n", "Se", "procedió", "a", "una", "cirugía", "exploradora", "en", "febrero", "de", "2015", ",", "apreciándose", "un", "nódulo", "de", "gran", "tamaño", "ocupando", "prácticamente", "toda", "la", "pirámide", "basal", "con", "adenopatías", "en", "cisura", "perivasculares", ";", "se", "practica", "una", "lobectomía", "inferior", "derecha", "y", "una", "disección", "ganglionar", "paratraqueal", "derecha", ",", "localizando", "además", "otra", "adenopatía", "precava", "(", "también", "resecada", ")", ".", "La", "biopsia", "confirma", "la", "proliferación", "celular", "mesenquimal", "atípica", "bien", "delimitada", ",", "no", "encapsulada", ",", "formando", "haces", "entrecruzados", "en", "alternancia", "con", "zonas", "de", "necrosis", "y", "degeneración", "de", "aspecto", "mixoide", ",", "además", "una", "población", "celular", "mayoritaria", "conformada", "por", "elementos", "fusiformes", ",", "sugestiva", "de", "TMVNP", ",", "aunque", "no", "se", "observa", "diferenciación", "rabdomiosarcomatosa", ".", "Los", "bordes", "quirúrgicos", "y", "las", "adenopatías", "están", "libres", ".", "\n\n", "Se", "considera", "que", "no", "hay", "criterios", "para", "tratamiento", "con", "QT", "pseudoadyuvante", "y", "la", "paciente", "sigue", "controles", "en", "nuestras", "consultas", "sin", "evidencia", "de", "enfermedad", "activa", "en", "el", "momento", "actual", "." ]

[ "MORFOLOGIA_NEOPLASIA" ]

neurofibromatosis, neurofibromas múltiples, cáncer, neurofibromatosis, tumoración, neurofibroma, sarcoma pleomorfico de alto grado, tumor maligno de la vaina nerviosa periférica, TMVNP, tumoración, neurofibromas múltiples, neurofibromas, TMVNP, tumoración, extensión local y a distancia, tumor, tumoración, TMVNP con diferenciación rabdomiosarcomatosa, tumor de tritón, nódulo pulmonar, metástasis única con tumor, TMVNP

679_task2

Sentence: Anamnesis Se trata de una mujer de 45 años de edad, como único antecedente patológico destaca una neurofibromatosis tipo 1 diagnosticada en la infancia en forma de neurofibromas múltiples subcutáneos, efélides axilares y manchas cafe-au-lait; no había habido afectación neurológica, ósea ni ocular. Su madre fue diagnosticada de un cáncer de colon a la edad de 67 años, pero no había antecedentes familiares de neurofibromatosis. Exploración física La paciente acudió inicialmente a su Hospital de referencia en Enero de 2013 con clínica de más de un año de evolución consistente en dolor y en la aparición de una tumoración en la escápula derecha. Se realizaron estudios de imagen con ecografía de tejidos blandos donde se apreciaba una masa solida de 45 mm con vascularización y características típicas de neurofibroma y posteriormente una resonancia de escapula derecha que describió una gran masa de 15 cm con necrosis central y signos de vascularización de "características benignas", con lo cual se procedió a realizar una resección marginal en de la lesión en diciembre de 2013. Desgraciadamente, el estudio patológico informó de un sarcoma pleomorfico de alto grado, compatible con un tumor maligno de la vaina nerviosa periférica (TMVNP). Con los datos de anatomía patológica y la cirugía no compartimental sin criterios oncológicos realizada, se procede a remitir a la paciente a nuestro hospital. En ese momento la paciente se encontraba bien, aunque refería rápida reaparición del dolor en el hombro tras la cirugía; en la exploración se aprecia una tumoración fija y gomosa en la escápula derecha. Se apreciaban múltiples neurofibromas múltiples subcutáneos, efélides axilares y manchas cafe-au-lait. Pruebas complementarias » PET-TAC de extensión en febrero de 2014: muestra una masa de partes blandas de 6,2 x 2,8 cm con intenso hipermetabolismo patológico (SUVmáx 20,2 g/ml) que erosiona la escápula derecha, sugestivo de comportamiento agresivo, además se observan múltiples nódulos en la piel, todos ametabólicos, que corresponden a neurofibromas cutáneos. Diagnóstico Expuesto el caso con estos datos en la comisión de tumores, se consideró que la paciente era candidata a tratamiento QT neoadyuvante (para disminuir la extensión de la lesión y con ello la morbilidad de la cirugía) seguida de cirugía con criterios radicales y radioterapia adyuvante. La paciente es incluida en el ensayo clínico GEIS 25 de QT neoadyuvante adaptada al histiotipo (epirrubicina-ifosfamida frente a ifosfamida-VP16 en el caso de TMVNP). La paciente recibe tres ciclos de ifosfamida-VP16 entre marzo y mayo de 2014, con evidente respuesta clínica desde el primer ciclo. La evaluación tras tres ciclos mostró una reducción muy significativa, mayor del 90 % de la tumoración, que se limita prácticamente a la fosa infraespinosa, con zonas avasculares en su interior sugestivas de necrosis, y ausencia de extensión local y a distancia. Vista la excelente respuesta parcial mayor tras la QT, se procede a la planificación de la cirugía con criterios oncológicos por parte del equipo de tumores óseos, realizando escapulectomía subtotal a través del cuello de la escápula manteniendo junto a la pieza extirpada el subescapular, supraespinoso, infraespinoso y redondo menor en junio de 2014. El resultado patológico de la pieza quirúrgica muestra una celularidad mayoritariamente pleomórfica con otras áreas de morfología fusocelular pura y estroma amplio mixoide, zonas de necrosis con células espumosas y células inflamatorias mononucleadas en aproximadamente el 50% del volumen total del tumor. En el estudio inmunohistoquímico las células pleomórficas expresan diferenciación muscular estriada (vimentina + desmina + calponina + miogenina + nuclear, MYOD1 + nuclear). Las fusiformes son focalmente positivas para MyoD1, CD34, y pS100. EMA, beta-catenina, AE1/3, actina. Los bordes de resección estaban libres de tumoración. Todos estos hallazgos eran compatibles con un TMVNP con diferenciación rabdomiosarcomatosa (tumor de tritón). Se complementa el tratamiento con RT externa adyuvante para una dosis total de 66 Gy. Tratamiento QTT neoadyuvante seguida de cirugía con criterios radicales y RT adyuvante. Evolución La paciente inicia seguimiento en nuestras consultas. En enero de 2015, seis meses tras la cirugía radical, se aprecia en la TC un nódulo pulmonar posterobasal derecho que mide aproximadamente 20 mm de diámetro. La PET-TC confirma la presencia de un nódulo redondeado de 26 x 26 x 29 mm hipermetabólico (SUVmáx 5,8 g/ml) en la base del LID, que ha crecido con respecto al estudio TC previa y que no aparecía en el estudio inicial. La paciente permanecía clínicamente asintomática. Dada la presencia de metástasis única con tumor primario controlado, remitimos a la paciente a cirugía torácica para valoración de metastasectomía pulmonar. Se procedió a una cirugía exploradora en febrero de 2015, apreciándose un nódulo de gran tamaño ocupando prácticamente toda la pirámide basal con adenopatías en cisura perivasculares; se practica una lobectomía inferior derecha y una disección ganglionar paratraqueal derecha, localizando además otra adenopatía precava (también resecada). La biopsia confirma la proliferación celular mesenquimal atípica bien delimitada, no encapsulada, formando haces entrecruzados en alternancia con zonas de necrosis y degeneración de aspecto mixoide, además una población celular mayoritaria conformada por elementos fusiformes, sugestiva de TMVNP, aunque no se observa diferenciación rabdomiosarcomatosa. Los bordes quirúrgicos y las adenopatías están libres. Se considera que no hay criterios para tratamiento con QT pseudoadyuvante y la paciente sigue controles en nuestras consultas sin evidencia de enfermedad activa en el momento actual. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "I-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-MORFOLOGIA_NEOPLASIA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Anamnesis Se trata de una mujer de 45 años de edad, como único antecedente patológico destaca una neurofibromatosis tipo 1 diagnosticada en la infancia en forma de neurofibromas múltiples subcutáneos, efélides axilares y manchas cafe-au-lait; no había habido afectación neurológica, ósea ni ocular. Su madre fue diagnosticada de un cáncer de colon a la edad de 67 años, pero no había antecedentes familiares de neurofibromatosis. Exploración física La paciente acudió inicialmente a su Hospital de referencia en Enero de 2013 con clínica de más de un año de evolución consistente en dolor y en la aparición de una tumoración en la escápula derecha. Se realizaron estudios de imagen con ecografía de tejidos blandos donde se apreciaba una masa solida de 45 mm con vascularización y características típicas de neurofibroma y posteriormente una resonancia de escapula derecha que describió una gran masa de 15 cm con necrosis central y signos de vascularización de "características benignas", con lo cual se procedió a realizar una resección marginal en de la lesión en diciembre de 2013. Desgraciadamente, el estudio patológico informó de un sarcoma pleomorfico de alto grado, compatible con un tumor maligno de la vaina nerviosa periférica (TMVNP). Con los datos de anatomía patológica y la cirugía no compartimental sin criterios oncológicos realizada, se procede a remitir a la paciente a nuestro hospital. En ese momento la paciente se encontraba bien, aunque refería rápida reaparición del dolor en el hombro tras la cirugía; en la exploración se aprecia una tumoración fija y gomosa en la escápula derecha. Se apreciaban múltiples neurofibromas múltiples subcutáneos, efélides axilares y manchas cafe-au-lait. Pruebas complementarias » PET-TAC de extensión en febrero de 2014: muestra una masa de partes blandas de 6,2 x 2,8 cm con intenso hipermetabolismo patológico (SUVmáx 20,2 g/ml) que erosiona la escápula derecha, sugestivo de comportamiento agresivo, además se observan múltiples nódulos en la piel, todos ametabólicos, que corresponden a neurofibromas cutáneos. Diagnóstico Expuesto el caso con estos datos en la comisión de tumores, se consideró que la paciente era candidata a tratamiento QT neoadyuvante (para disminuir la extensión de la lesión y con ello la morbilidad de la cirugía) seguida de cirugía con criterios radicales y radioterapia adyuvante. La paciente es incluida en el ensayo clínico GEIS 25 de QT neoadyuvante adaptada al histiotipo (epirrubicina-ifosfamida frente a ifosfamida-VP16 en el caso de TMVNP). La paciente recibe tres ciclos de ifosfamida-VP16 entre marzo y mayo de 2014, con evidente respuesta clínica desde el primer ciclo. La evaluación tras tres ciclos mostró una reducción muy significativa, mayor del 90 % de la tumoración, que se limita prácticamente a la fosa infraespinosa, con zonas avasculares en su interior sugestivas de necrosis, y ausencia de extensión local y a distancia. Vista la excelente respuesta parcial mayor tras la QT, se procede a la planificación de la cirugía con criterios oncológicos por parte del equipo de tumores óseos, realizando escapulectomía subtotal a través del cuello de la escápula manteniendo junto a la pieza extirpada el subescapular, supraespinoso, infraespinoso y redondo menor en junio de 2014. El resultado patológico de la pieza quirúrgica muestra una celularidad mayoritariamente pleomórfica con otras áreas de morfología fusocelular pura y estroma amplio mixoide, zonas de necrosis con células espumosas y células inflamatorias mononucleadas en aproximadamente el 50% del volumen total del tumor. En el estudio inmunohistoquímico las células pleomórficas expresan diferenciación muscular estriada (vimentina + desmina + calponina + miogenina + nuclear, MYOD1 + nuclear). Las fusiformes son focalmente positivas para MyoD1, CD34, y pS100. EMA, beta-catenina, AE1/3, actina. Los bordes de resección estaban libres de tumoración. Todos estos hallazgos eran compatibles con un TMVNP con diferenciación rabdomiosarcomatosa (tumor de tritón). Se complementa el tratamiento con RT externa adyuvante para una dosis total de 66 Gy. Tratamiento QTT neoadyuvante seguida de cirugía con criterios radicales y RT adyuvante. Evolución La paciente inicia seguimiento en nuestras consultas. En enero de 2015, seis meses tras la cirugía radical, se aprecia en la TC un nódulo pulmonar posterobasal derecho que mide aproximadamente 20 mm de diámetro. La PET-TC confirma la presencia de un nódulo redondeado de 26 x 26 x 29 mm hipermetabólico (SUVmáx 5,8 g/ml) en la base del LID, que ha crecido con respecto al estudio TC previa y que no aparecía en el estudio inicial. La paciente permanecía clínicamente asintomática. Dada la presencia de metástasis única con tumor primario controlado, remitimos a la paciente a cirugía torácica para valoración de metastasectomía pulmonar. Se procedió a una cirugía exploradora en febrero de 2015, apreciándose un nódulo de gran tamaño ocupando prácticamente toda la pirámide basal con adenopatías en cisura perivasculares; se practica una lobectomía inferior derecha y una disección ganglionar paratraqueal derecha, localizando además otra adenopatía precava (también resecada). La biopsia confirma la proliferación celular mesenquimal atípica bien delimitada, no encapsulada, formando haces entrecruzados en alternancia con zonas de necrosis y degeneración de aspecto mixoide, además una población celular mayoritaria conformada por elementos fusiformes, sugestiva de TMVNP, aunque no se observa diferenciación rabdomiosarcomatosa. Los bordes quirúrgicos y las adenopatías están libres. Se considera que no hay criterios para tratamiento con QT pseudoadyuvante y la paciente sigue controles en nuestras consultas sin evidencia de enfermedad activa en el momento actual.

[ "Anamnesis", "\n", "Se", "trata", "de", "una", "mujer", "de", "45", "años", "de", "edad", ",", "como", "único", "antecedente", "patológico", "destaca", "una", "neurofibromatosis", "tipo", "1", "diagnosticada", "en", "la", "infancia", "en", "forma", "de", "neurofibromas", "múltiples", "subcutáneos", ",", "efélides", "axilares", "y", "manchas", "cafe", "-", "au", "-", "lait", ";", "no", "había", "habido", "afectación", "neurológica", ",", "ósea", "ni", "ocular", ".", "Su", "madre", "fue", "diagnosticada", "de", "un", "cáncer", "de", "colon", "a", "la", "edad", "de", "67", "años", ",", "pero", "no", "había", "antecedentes", "familiares", "de", "neurofibromatosis", ".", "\n\n", "Exploración", "física", "\n", "La", "paciente", "acudió", "inicialmente", "a", "su", "Hospital", "de", "referencia", "en", "Enero", "de", "2013", "con", "clínica", "de", "más", "de", "un", "año", "de", "evolución", "consistente", "en", "dolor", "y", "en", "la", "aparición", "de", "una", "tumoración", "en", "la", "escápula", "derecha", ".", "Se", "realizaron", "estudios", "de", "imagen", "con", "ecografía", "de", "tejidos", "blandos", "donde", "se", "apreciaba", "una", "masa", "solida", "de", "45", "mm", "con", "vascularización", "y", "características", "típicas", "de", "neurofibroma", "y", "posteriormente", "una", "resonancia", "de", "escapula", "derecha", "que", "describió", "una", "gran", "masa", "de", "15", "cm", "con", "necrosis", "central", "y", "signos", "de", "vascularización", "de", "\"", "características", "benignas", "\"", ",", "con", "lo", "cual", "se", "procedió", "a", "realizar", "una", "resección", "marginal", "en", "de", "la", "lesión", "en", "diciembre", "de", "2013", ".", "Desgraciadamente", ",", "el", "estudio", "patológico", "informó", "de", "un", "sarcoma", "pleomorfico", "de", "alto", "grado", ",", "compatible", "con", "un", "tumor", "maligno", "de", "la", "vaina", "nerviosa", "periférica", "(", "TMVNP", ")", ".", "\n\n", "Con", "los", "datos", "de", "anatomía", "patológica", "y", "la", "cirugía", "no", "compartimental", "sin", "criterios", "oncológicos", "realizada", ",", "se", "procede", "a", "remitir", "a", "la", "paciente", "a", "nuestro", "hospital", ".", "En", "ese", "momento", "la", "paciente", "se", "encontraba", "bien", ",", "aunque", "refería", "rápida", "reaparición", "del", "dolor", "en", "el", "hombro", "tras", "la", "cirugía", ";", "en", "la", "exploración", "se", "aprecia", "una", "tumoración", "fija", "y", "gomosa", "en", "la", "escápula", "derecha", ".", "Se", "apreciaban", "múltiples", "neurofibromas", "múltiples", "subcutáneos", ",", "efélides", "axilares", "y", "manchas", "cafe", "-", "au", "-", "lait", ".", "\n\n", "Pruebas", "complementarias", "\n", "»", "PET", "-", "TAC", "de", "extensión", "en", "febrero", "de", "2014", ":", "muestra", "una", "masa", "de", "partes", "blandas", "de", "6,2", "x", "2,8", "cm", "con", "intenso", "hipermetabolismo", "patológico", "(", "SUVmáx", "20,2", "g", "/", "ml", ")", "que", "erosiona", "la", "escápula", "derecha", ",", "sugestivo", "de", "comportamiento", "agresivo", ",", "además", "se", "observan", "múltiples", "nódulos", "en", "la", "piel", ",", "todos", "ametabólicos", ",", "que", "corresponden", "a", "neurofibromas", "cutáneos", ".", "\n\n", "Diagnóstico", "\n", "Expuesto", "el", "caso", "con", "estos", "datos", "en", "la", "comisión", "de", "tumores", ",", "se", "consideró", "que", "la", "paciente", "era", "candidata", "a", "tratamiento", "QT", "neoadyuvante", "(", "para", "disminuir", "la", "extensión", "de", "la", "lesión", "y", "con", "ello", "la", "morbilidad", "de", "la", "cirugía", ")", "seguida", "de", "cirugía", "con", "criterios", "radicales", "y", "radioterapia", "adyuvante", ".", "\n\n", "La", "paciente", "es", "incluida", "en", "el", "ensayo", "clínico", "GEIS", "25", "de", "QT", "neoadyuvante", "adaptada", "al", "histiotipo", "(", "epirrubicina", "-", "ifosfamida", "frente", "a", "ifosfamida", "-", "VP16", "en", "el", "caso", "de", "TMVNP", ")", ".", "La", "paciente", "recibe", "tres", "ciclos", "de", "ifosfamida", "-", "VP16", "entre", "marzo", "y", "mayo", "de", "2014", ",", "con", "evidente", "respuesta", "clínica", "desde", "el", "primer", "ciclo", ".", "La", "evaluación", "tras", "tres", "ciclos", "mostró", "una", "reducción", "muy", "significativa", ",", "mayor", "del", "90", "%", "de", "la", "tumoración", ",", "que", "se", "limita", "prácticamente", "a", "la", "fosa", "infraespinosa", ",", "con", "zonas", "avasculares", "en", "su", "interior", "sugestivas", "de", "necrosis", ",", "y", "ausencia", "de", "extensión", "local", "y", "a", "distancia", ".", "\n\n", "Vista", "la", "excelente", "respuesta", "parcial", "mayor", "tras", "la", "QT", ",", "se", "procede", "a", "la", "planificación", "de", "la", "cirugía", "con", "criterios", "oncológicos", "por", "parte", "del", "equipo", "de", "tumores", "óseos", ",", "realizando", "escapulectomía", "subtotal", "a", "través", "del", "cuello", "de", "la", "escápula", "manteniendo", "junto", "a", "la", "pieza", "extirpada", "el", "subescapular", ",", "supraespinoso", ",", "infraespinoso", "y", "redondo", "menor", "en", "junio", "de", "2014", ".", "\n\n", "El", "resultado", "patológico", "de", "la", "pieza", "quirúrgica", "muestra", "una", "celularidad", "mayoritariamente", "pleomórfica", "con", "otras", "áreas", "de", "morfología", "fusocelular", "pura", "y", "estroma", "amplio", "mixoide", ",", "zonas", "de", "necrosis", "con", "células", "espumosas", "y", "células", "inflamatorias", "mononucleadas", "en", "aproximadamente", "el", "50", "%", "del", "volumen", "total", "del", "tumor", ".", "En", "el", "estudio", "inmunohistoquímico", "las", "células", "pleomórficas", "expresan", "diferenciación", "muscular", "estriada", "(", "vimentina", "+", "desmina", "+", "calponina", "+", "miogenina", "+", "nuclear", ",", "MYOD1", "+", "nuclear", ")", ".", "Las", "fusiformes", "son", "focalmente", "positivas", "para", "MyoD1", ",", "CD34", ",", "y", "pS100", ".", "EMA", ",", "beta", "-", "catenina", ",", "AE1/3", ",", "actina", ".", "Los", "bordes", "de", "resección", "estaban", "libres", "de", "tumoración", ".", "Todos", "estos", "hallazgos", "eran", "compatibles", "con", "un", "TMVNP", "con", "diferenciación", "rabdomiosarcomatosa", "(", "tumor", "de", "tritón", ")", ".", "\n\n", "Se", "complementa", "el", "tratamiento", "con", "RT", "externa", "adyuvante", "para", "una", "dosis", "total", "de", "66", "Gy", ".", "\n\n", "Tratamiento", "\n", "QTT", "neoadyuvante", "seguida", "de", "cirugía", "con", "criterios", "radicales", "y", "RT", "adyuvante", ".", "\n\n", "Evolución", "\n", "La", "paciente", "inicia", "seguimiento", "en", "nuestras", "consultas", ".", "En", "enero", "de", "2015", ",", "seis", "meses", "tras", "la", "cirugía", "radical", ",", "se", "aprecia", "en", "la", "TC", "un", "nódulo", "pulmonar", "posterobasal", "derecho", "que", "mide", "aproximadamente", "20", "mm", "de", "diámetro", ".", "La", "PET", "-", "TC", "confirma", "la", "presencia", "de", "un", "nódulo", "redondeado", "de", "26", "x", "26", "x", "29", "mm", "hipermetabólico", "(", "SUVmáx", "5,8", "g", "/", "ml", ")", "en", "la", "base", "del", "LID", ",", "que", "ha", "crecido", "con", "respecto", "al", "estudio", "TC", "previa", "y", "que", "no", "aparecía", "en", "el", "estudio", "inicial", ".", "La", "paciente", "permanecía", "clínicamente", "asintomática", ".", "\n\n", "Dada", "la", "presencia", "de", "metástasis", "única", "con", "tumor", "primario", "controlado", ",", "remitimos", "a", "la", "paciente", "a", "cirugía", "torácica", "para", "valoración", "de", "metastasectomía", "pulmonar", ".", "\n\n", "Se", "procedió", "a", "una", "cirugía", "exploradora", "en", "febrero", "de", "2015", ",", "apreciándose", "un", "nódulo", "de", "gran", "tamaño", "ocupando", "prácticamente", "toda", "la", "pirámide", "basal", "con", "adenopatías", "en", "cisura", "perivasculares", ";", "se", "practica", "una", "lobectomía", "inferior", "derecha", "y", "una", "disección", "ganglionar", "paratraqueal", "derecha", ",", "localizando", "además", "otra", "adenopatía", "precava", "(", "también", "resecada", ")", ".", "La", "biopsia", "confirma", "la", "proliferación", "celular", "mesenquimal", "atípica", "bien", "delimitada", ",", "no", "encapsulada", ",", "formando", "haces", "entrecruzados", "en", "alternancia", "con", "zonas", "de", "necrosis", "y", "degeneración", "de", "aspecto", "mixoide", ",", "además", "una", "población", "celular", "mayoritaria", "conformada", "por", "elementos", "fusiformes", ",", "sugestiva", "de", "TMVNP", ",", "aunque", "no", "se", "observa", "diferenciación", "rabdomiosarcomatosa", ".", "Los", "bordes", "quirúrgicos", "y", "las", "adenopatías", "están", "libres", ".", "\n\n", "Se", "considera", "que", "no", "hay", "criterios", "para", "tratamiento", "con", "QT", "pseudoadyuvante", "y", "la", "paciente", "sigue", "controles", "en", "nuestras", "consultas", "sin", "evidencia", "de", "enfermedad", "activa", "en", "el", "momento", "actual", "." ]

[ "MORFOLOGIA_NEOPLASIA" ]

Nitric oxide is a compound, IL-6 is a protein

DS.d1467_task0

Sentence: Nitric oxide (NO) and interlukin-6 (IL-6) are highly reactive mediators that have been shown to play different roles in a variety of different biological process. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein

[ "B-compound", "I-compound", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Nitric oxide (NO) and interlukin-6 (IL-6) are highly reactive mediators that have been shown to play different roles in a variety of different biological process.

[ "Nitric", "oxide", "(", "NO", ")", "and", "interlukin-6", "(", "IL-6", ")", "are", "highly", "reactive", "mediators", "that", "have", "been", "shown", "to", "play", "different", "roles", "in", "a", "variety", "of", "different", "biological", "process", "." ]

[ "compound", "protein" ]

Nitric oxide is a compound, IL-6 is a protein

DS.d1467_task1

Sentence: Nitric oxide (NO) and interlukin-6 (IL-6) are highly reactive mediators that have been shown to play different roles in a variety of different biological process. Instructions: please typing these entity words according to sentence: Nitric oxide, IL-6 Options: compound, protein

[ "B-compound", "I-compound", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Nitric oxide (NO) and interlukin-6 (IL-6) are highly reactive mediators that have been shown to play different roles in a variety of different biological process.

[ "Nitric", "oxide", "(", "NO", ")", "and", "interlukin-6", "(", "IL-6", ")", "are", "highly", "reactive", "mediators", "that", "have", "been", "shown", "to", "play", "different", "roles", "in", "a", "variety", "of", "different", "biological", "process", "." ]

[ "compound", "protein" ]

Nitric oxide, IL-6

DS.d1467_task2

Sentence: Nitric oxide (NO) and interlukin-6 (IL-6) are highly reactive mediators that have been shown to play different roles in a variety of different biological process. Instructions: please extract entity words from the input sentence

[ "B-compound", "I-compound", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Nitric oxide (NO) and interlukin-6 (IL-6) are highly reactive mediators that have been shown to play different roles in a variety of different biological process.

[ "Nitric", "oxide", "(", "NO", ")", "and", "interlukin-6", "(", "IL-6", ")", "are", "highly", "reactive", "mediators", "that", "have", "been", "shown", "to", "play", "different", "roles", "in", "a", "variety", "of", "different", "biological", "process", "." ]

[ "compound", "protein" ]

profilin is a Individual_protein, actin is a Individual_protein

404_task0

Sentence: In Acanthamoeba, the two isoforms of profilin may have specialized functions on the basis of their identical (approximately 10 microM) affinities for actin monomers and different affinities for PIP2. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Individual_protein

[ "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O" ]

In Acanthamoeba, the two isoforms of profilin may have specialized functions on the basis of their identical (approximately 10 microM) affinities for actin monomers and different affinities for PIP2.

[ "In", "Acanthamoeba", ",", "the", "two", "isoforms", "of", "profilin", "may", "have", "specialized", "functions", "on", "the", "basis", "of", "their", "identical", "(", "approximately", "10", "microM", ")", "affinities", "for", "actin", "monomers", "and", "different", "affinities", "for", "PIP2", "." ]

[ "Individual_protein" ]

profilin is a Individual_protein, actin is a Individual_protein

404_task1

Sentence: In Acanthamoeba, the two isoforms of profilin may have specialized functions on the basis of their identical (approximately 10 microM) affinities for actin monomers and different affinities for PIP2. Instructions: please typing these entity words according to sentence: profilin, actin Options: Individual_protein

[ "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O" ]

In Acanthamoeba, the two isoforms of profilin may have specialized functions on the basis of their identical (approximately 10 microM) affinities for actin monomers and different affinities for PIP2.

[ "In", "Acanthamoeba", ",", "the", "two", "isoforms", "of", "profilin", "may", "have", "specialized", "functions", "on", "the", "basis", "of", "their", "identical", "(", "approximately", "10", "microM", ")", "affinities", "for", "actin", "monomers", "and", "different", "affinities", "for", "PIP2", "." ]

[ "Individual_protein" ]

profilin, actin

404_task2

Sentence: In Acanthamoeba, the two isoforms of profilin may have specialized functions on the basis of their identical (approximately 10 microM) affinities for actin monomers and different affinities for PIP2. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "O", "O" ]

In Acanthamoeba, the two isoforms of profilin may have specialized functions on the basis of their identical (approximately 10 microM) affinities for actin monomers and different affinities for PIP2.

[ "In", "Acanthamoeba", ",", "the", "two", "isoforms", "of", "profilin", "may", "have", "specialized", "functions", "on", "the", "basis", "of", "their", "identical", "(", "approximately", "10", "microM", ")", "affinities", "for", "actin", "monomers", "and", "different", "affinities", "for", "PIP2", "." ]

[ "Individual_protein" ]

temozolomide is a compound, Fas is a protein

DS.d421_task0

Sentence: This additive effect was not observed when glioma cells were pre-treated with temozolomide, which was unable to increase Fas expression in tumor. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O" ]

This additive effect was not observed when glioma cells were pre-treated with temozolomide, which was unable to increase Fas expression in tumor.

[ "This", "additive", "effect", "was", "not", "observed", "when", "glioma", "cells", "were", "pre", "-", "treated", "with", "temozolomide", ",", "which", "was", "unable", "to", "increase", "Fas", "expression", "in", "tumor", "." ]

[ "compound", "protein" ]

temozolomide is a compound, Fas is a protein

DS.d421_task1

Sentence: This additive effect was not observed when glioma cells were pre-treated with temozolomide, which was unable to increase Fas expression in tumor. Instructions: please typing these entity words according to sentence: temozolomide, Fas Options: compound, protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O" ]

This additive effect was not observed when glioma cells were pre-treated with temozolomide, which was unable to increase Fas expression in tumor.

[ "This", "additive", "effect", "was", "not", "observed", "when", "glioma", "cells", "were", "pre", "-", "treated", "with", "temozolomide", ",", "which", "was", "unable", "to", "increase", "Fas", "expression", "in", "tumor", "." ]

[ "compound", "protein" ]

temozolomide, Fas

DS.d421_task2

Sentence: This additive effect was not observed when glioma cells were pre-treated with temozolomide, which was unable to increase Fas expression in tumor. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O" ]

This additive effect was not observed when glioma cells were pre-treated with temozolomide, which was unable to increase Fas expression in tumor.

[ "This", "additive", "effect", "was", "not", "observed", "when", "glioma", "cells", "were", "pre", "-", "treated", "with", "temozolomide", ",", "which", "was", "unable", "to", "increase", "Fas", "expression", "in", "tumor", "." ]

[ "compound", "protein" ]

Kindes- is an umlsterm, Jugendlichenalter is an umlsterm, -Syndrom is an umlsterm, supraventrikulaere Tachykardien is an umlsterm, Synkope is an umlsterm, Herz - Kreislauf - Stillstand is an umlsterm, Reanimation is an umlsterm

MonatsschriftKinderheilkunde.71450020.ger.abstr_task0

Sentence: Im Kindes- und Jugendlichenalter manifestiert sich das Wolff-Parkinson-White ( WPW ) -Syndrom fast ausschliesslich durch paroxysmale supraventrikulaere Tachykardien . Ursache einer Synkope bei einem 15 Jahre alten , zuvor voellig asymptomatischen Jugendlichen war ein durch Kammerflattern bedingter Herz-Kreislauf-Stillstand . Nach erfolgreicher Reanimation zeigte sich im Elektrokardiogramm ein klassisches Praeexzitationsmuster . Bei der elektrophysiologischen Untersuchung fand sich eine linksposterior lokalisierte akzessorische Leitungsbahn , die dann durch Hochfrequenzapplikation erfolgreich abladiert wurde . Seither ist der Junge beschwerdefrei . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Im Kindes- und Jugendlichenalter manifestiert sich das Wolff-Parkinson-White ( WPW ) -Syndrom fast ausschliesslich durch paroxysmale supraventrikulaere Tachykardien . Ursache einer Synkope bei einem 15 Jahre alten , zuvor voellig asymptomatischen Jugendlichen war ein durch Kammerflattern bedingter Herz-Kreislauf-Stillstand . Nach erfolgreicher Reanimation zeigte sich im Elektrokardiogramm ein klassisches Praeexzitationsmuster . Bei der elektrophysiologischen Untersuchung fand sich eine linksposterior lokalisierte akzessorische Leitungsbahn , die dann durch Hochfrequenzapplikation erfolgreich abladiert wurde . Seither ist der Junge beschwerdefrei .

[ "Im", "Kindes-", "und", "Jugendlichenalter", "manifestiert", "sich", "das", "Wolff", "-", "Parkinson", "-", "White", "(", "WPW", ")", "-Syndrom", "fast", "ausschliesslich", "durch", "paroxysmale", "supraventrikulaere", "Tachykardien", ".", "Ursache", "einer", "Synkope", "bei", "einem", "15", "Jahre", "alten", ",", "zuvor", "voellig", "asymptomatischen", "Jugendlichen", "war", "ein", "durch", "Kammerflattern", "bedingter", "Herz", "-", "Kreislauf", "-", "Stillstand", ".", "Nach", "erfolgreicher", "Reanimation", "zeigte", "sich", "im", "Elektrokardiogramm", "ein", "klassisches", "Praeexzitationsmuster", ".", "Bei", "der", "elektrophysiologischen", "Untersuchung", "fand", "sich", "eine", "linksposterior", "lokalisierte", "akzessorische", "Leitungsbahn", ",", "die", "dann", "durch", "Hochfrequenzapplikation", "erfolgreich", "abladiert", "wurde", ".", "Seither", "ist", "der", "Junge", "beschwerdefrei", "." ]

[ "umlsterm" ]