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dependent and nondependent harmful drinkers ., receive or not to receive diagnostic information and counseling directives on, binary logistic regression, Physician prompting, dependent drinking, recent disorder activity, physician counseling and improvements
85206_task2
Sentence: A program of screening and prompting improves short-term physician counseling of dependent and nondependent harmful drinkers . BACKGROUND Physicians in the general medical setting commonly encounter but rarely counsel patients with dependent or harmful drinking behaviors . We tested whether providing physicians with their patients ' results on the alcohol module of the Diagnostic Interview Schedule and counseling directives would prompt them to counsel these patients . METHODS We randomly assigned 83 first- , second- , and third-year medical residents to receive or not to receive diagnostic information and counseling directives on 214 patients who reported at least one symptom of alcohol impairment as defined in the Diagnostic and Statistical Manual of Mental Disorders , Third Edition . Using binary logistic regression , we examined the effect of specific covariables on rates of physician counseling . These variables included physician information status , patient gender , and drinking disorder severity and recency . We also examined the effect of physician prompting on counseling of female patients , patients with inactive disorders , and nondependent but harmful drinkers . We determined counseling by post-visit patient interviews . RESULTS Physician prompting , dependent drinking , and recent disorder activity were significant correlates of physician counseling ( P < .05 ) , while male gender was a marginally significant correlate ( P = .08 ) . Informed physicians counseled female patients , harmful but nondependent drinkers , and patients with inactive disorders more often than their uninformed colleagues , although only the last variable achieved statistical significance . CONCLUSIONS Providing physicians with the results of the Diagnostic Interview Schedule and counseling directives resulted in short-term improvement in their rates of counseling patients with a history of dependent or nondependent but harmful drinking . Further research is necessary to determine long-term gains in rates of physician counseling and improvements in the course of these patients . Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "O", "B-Outcome_Mental", "I-Outcome_Mental", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O" ]
A program of screening and prompting improves short-term physician counseling of dependent and nondependent harmful drinkers . BACKGROUND Physicians in the general medical setting commonly encounter but rarely counsel patients with dependent or harmful drinking behaviors . We tested whether providing physicians with their patients ' results on the alcohol module of the Diagnostic Interview Schedule and counseling directives would prompt them to counsel these patients . METHODS We randomly assigned 83 first- , second- , and third-year medical residents to receive or not to receive diagnostic information and counseling directives on 214 patients who reported at least one symptom of alcohol impairment as defined in the Diagnostic and Statistical Manual of Mental Disorders , Third Edition . Using binary logistic regression , we examined the effect of specific covariables on rates of physician counseling . These variables included physician information status , patient gender , and drinking disorder severity and recency . We also examined the effect of physician prompting on counseling of female patients , patients with inactive disorders , and nondependent but harmful drinkers . We determined counseling by post-visit patient interviews . RESULTS Physician prompting , dependent drinking , and recent disorder activity were significant correlates of physician counseling ( P < .05 ) , while male gender was a marginally significant correlate ( P = .08 ) . Informed physicians counseled female patients , harmful but nondependent drinkers , and patients with inactive disorders more often than their uninformed colleagues , although only the last variable achieved statistical significance . CONCLUSIONS Providing physicians with the results of the Diagnostic Interview Schedule and counseling directives resulted in short-term improvement in their rates of counseling patients with a history of dependent or nondependent but harmful drinking . Further research is necessary to determine long-term gains in rates of physician counseling and improvements in the course of these patients .
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[ "Intervention_Educational", "Participant_Condition", "Outcome_Mental" ]
Immunsystems is an umlsterm, Trauma is an umlsterm, Verletzung is an umlsterm, Makrophagen is an umlsterm, Noxen is an umlsterm, Therapie is an umlsterm, Tiermodelluntersuchungen is an umlsterm, Komplikationen is an umlsterm, Therapiestrategien is an umlsterm, Patient is an umlsterm, Verletzung is an umlsterm
DerUnfallchirurg.71000324.ger.abstr_task0
Sentence: Die Antwort des Immunsystems auf ein Trauma beginnt im Augenblick der Verletzung ; Makrophagen werden aktiviert und produzieren proinflammatorische Mediatoren . Alle Noxen und Stimuli des Zytokinsystems muenden in einer gemeinsamen Endstrecke und bieten einen therapeutischen Ansatz . Jeder Versuch einer Strategie zur Therapie mit Zytokinen ist ein zweischneidiges Schwert . Es gibt viel Information aus In-vitro- und Tiermodelluntersuchungen . Einordnung und klinische Umsetzung sind jedoch schwer . Obwohl einige der vorliegenden Strategien und Konzepte fuer die Zukunft erfolgversprechend erscheinen , muessen die Vorteile und Komplikationen sorgfaeltig abgewogen werden . Ziel aller Therapiestrategien muss es sein , die Abwehrlage zu unterstuetzen oder positiv zu modulieren . Dabei ist immer der Patient , die Erkrankung oder Verletzung zu behandeln nicht aber nur die Mediatoren . Der Weisheit letzter Schluss ist hier noch nicht gefunden . Ansaetze sind vorhanden , der Weg ist allerdings noch weit , steinig und schwierig . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Die Antwort des Immunsystems auf ein Trauma beginnt im Augenblick der Verletzung ; Makrophagen werden aktiviert und produzieren proinflammatorische Mediatoren . Alle Noxen und Stimuli des Zytokinsystems muenden in einer gemeinsamen Endstrecke und bieten einen therapeutischen Ansatz . Jeder Versuch einer Strategie zur Therapie mit Zytokinen ist ein zweischneidiges Schwert . Es gibt viel Information aus In-vitro- und Tiermodelluntersuchungen . Einordnung und klinische Umsetzung sind jedoch schwer . Obwohl einige der vorliegenden Strategien und Konzepte fuer die Zukunft erfolgversprechend erscheinen , muessen die Vorteile und Komplikationen sorgfaeltig abgewogen werden . Ziel aller Therapiestrategien muss es sein , die Abwehrlage zu unterstuetzen oder positiv zu modulieren . Dabei ist immer der Patient , die Erkrankung oder Verletzung zu behandeln nicht aber nur die Mediatoren . Der Weisheit letzter Schluss ist hier noch nicht gefunden . Ansaetze sind vorhanden , der Weg ist allerdings noch weit , steinig und schwierig .
[ "Die", "Antwort", "des", "Immunsystems", "auf", "ein", "Trauma", "beginnt", "im", "Augenblick", "der", "Verletzung", ";", "Makrophagen", "werden", "aktiviert", "und", "produzieren", "proinflammatorische", "Mediatoren", ".", "Alle", "Noxen", "und", "Stimuli", "des", "Zytokinsystems", "muenden", "in", "einer", "gemeinsamen", "Endstrecke", "und", "bieten", "einen", "therapeutischen", "Ansatz", ".", "Jeder", "Versuch", "einer", "Strategie", "zur", "Therapie", "mit", "Zytokinen", "ist", "ein", "zweischneidiges", "Schwert", ".", "Es", "gibt", "viel", "Information", "aus", "In", "-", "vitro-", "und", "Tiermodelluntersuchungen", ".", "Einordnung", "und", "klinische", "Umsetzung", "sind", "jedoch", "schwer", ".", "Obwohl", "einige", "der", "vorliegenden", "Strategien", "und", "Konzepte", "fuer", "die", "Zukunft", "erfolgversprechend", "erscheinen", ",", "muessen", "die", "Vorteile", "und", "Komplikationen", "sorgfaeltig", "abgewogen", "werden", ".", "Ziel", "aller", "Therapiestrategien", "muss", "es", "sein", ",", "die", "Abwehrlage", "zu", "unterstuetzen", "oder", "positiv", "zu", "modulieren", ".", "Dabei", "ist", "immer", "der", "Patient", ",", "die", "Erkrankung", "oder", "Verletzung", "zu", "behandeln", "nicht", "aber", "nur", "die", "Mediatoren", ".", "Der", "Weisheit", "letzter", "Schluss", "ist", "hier", "noch", "nicht", "gefunden", ".", "Ansaetze", "sind", "vorhanden", ",", "der", "Weg", "ist", "allerdings", "noch", "weit", ",", "steinig", "und", "schwierig", "." ]
[ "umlsterm" ]
Immunsystems is an umlsterm, Trauma is an umlsterm, Verletzung is an umlsterm, Makrophagen is an umlsterm, Noxen is an umlsterm, Therapie is an umlsterm, Tiermodelluntersuchungen is an umlsterm, Komplikationen is an umlsterm, Therapiestrategien is an umlsterm, Patient is an umlsterm, Verletzung is an umlsterm
DerUnfallchirurg.71000324.ger.abstr_task1
Sentence: Die Antwort des Immunsystems auf ein Trauma beginnt im Augenblick der Verletzung ; Makrophagen werden aktiviert und produzieren proinflammatorische Mediatoren . Alle Noxen und Stimuli des Zytokinsystems muenden in einer gemeinsamen Endstrecke und bieten einen therapeutischen Ansatz . Jeder Versuch einer Strategie zur Therapie mit Zytokinen ist ein zweischneidiges Schwert . Es gibt viel Information aus In-vitro- und Tiermodelluntersuchungen . Einordnung und klinische Umsetzung sind jedoch schwer . Obwohl einige der vorliegenden Strategien und Konzepte fuer die Zukunft erfolgversprechend erscheinen , muessen die Vorteile und Komplikationen sorgfaeltig abgewogen werden . Ziel aller Therapiestrategien muss es sein , die Abwehrlage zu unterstuetzen oder positiv zu modulieren . Dabei ist immer der Patient , die Erkrankung oder Verletzung zu behandeln nicht aber nur die Mediatoren . Der Weisheit letzter Schluss ist hier noch nicht gefunden . Ansaetze sind vorhanden , der Weg ist allerdings noch weit , steinig und schwierig . Instructions: please typing these entity words according to sentence: Immunsystems, Trauma, Verletzung, Makrophagen, Noxen, Therapie, Tiermodelluntersuchungen, Komplikationen, Therapiestrategien, Patient, Verletzung Options: umlsterm
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Die Antwort des Immunsystems auf ein Trauma beginnt im Augenblick der Verletzung ; Makrophagen werden aktiviert und produzieren proinflammatorische Mediatoren . Alle Noxen und Stimuli des Zytokinsystems muenden in einer gemeinsamen Endstrecke und bieten einen therapeutischen Ansatz . Jeder Versuch einer Strategie zur Therapie mit Zytokinen ist ein zweischneidiges Schwert . Es gibt viel Information aus In-vitro- und Tiermodelluntersuchungen . Einordnung und klinische Umsetzung sind jedoch schwer . Obwohl einige der vorliegenden Strategien und Konzepte fuer die Zukunft erfolgversprechend erscheinen , muessen die Vorteile und Komplikationen sorgfaeltig abgewogen werden . Ziel aller Therapiestrategien muss es sein , die Abwehrlage zu unterstuetzen oder positiv zu modulieren . Dabei ist immer der Patient , die Erkrankung oder Verletzung zu behandeln nicht aber nur die Mediatoren . Der Weisheit letzter Schluss ist hier noch nicht gefunden . Ansaetze sind vorhanden , der Weg ist allerdings noch weit , steinig und schwierig .
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[ "umlsterm" ]
Immunsystems, Trauma, Verletzung, Makrophagen, Noxen, Therapie, Tiermodelluntersuchungen, Komplikationen, Therapiestrategien, Patient, Verletzung
DerUnfallchirurg.71000324.ger.abstr_task2
Sentence: Die Antwort des Immunsystems auf ein Trauma beginnt im Augenblick der Verletzung ; Makrophagen werden aktiviert und produzieren proinflammatorische Mediatoren . Alle Noxen und Stimuli des Zytokinsystems muenden in einer gemeinsamen Endstrecke und bieten einen therapeutischen Ansatz . Jeder Versuch einer Strategie zur Therapie mit Zytokinen ist ein zweischneidiges Schwert . Es gibt viel Information aus In-vitro- und Tiermodelluntersuchungen . Einordnung und klinische Umsetzung sind jedoch schwer . Obwohl einige der vorliegenden Strategien und Konzepte fuer die Zukunft erfolgversprechend erscheinen , muessen die Vorteile und Komplikationen sorgfaeltig abgewogen werden . Ziel aller Therapiestrategien muss es sein , die Abwehrlage zu unterstuetzen oder positiv zu modulieren . Dabei ist immer der Patient , die Erkrankung oder Verletzung zu behandeln nicht aber nur die Mediatoren . Der Weisheit letzter Schluss ist hier noch nicht gefunden . Ansaetze sind vorhanden , der Weg ist allerdings noch weit , steinig und schwierig . Instructions: please extract entity words from the input sentence
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Die Antwort des Immunsystems auf ein Trauma beginnt im Augenblick der Verletzung ; Makrophagen werden aktiviert und produzieren proinflammatorische Mediatoren . Alle Noxen und Stimuli des Zytokinsystems muenden in einer gemeinsamen Endstrecke und bieten einen therapeutischen Ansatz . Jeder Versuch einer Strategie zur Therapie mit Zytokinen ist ein zweischneidiges Schwert . Es gibt viel Information aus In-vitro- und Tiermodelluntersuchungen . Einordnung und klinische Umsetzung sind jedoch schwer . Obwohl einige der vorliegenden Strategien und Konzepte fuer die Zukunft erfolgversprechend erscheinen , muessen die Vorteile und Komplikationen sorgfaeltig abgewogen werden . Ziel aller Therapiestrategien muss es sein , die Abwehrlage zu unterstuetzen oder positiv zu modulieren . Dabei ist immer der Patient , die Erkrankung oder Verletzung zu behandeln nicht aber nur die Mediatoren . Der Weisheit letzter Schluss ist hier noch nicht gefunden . Ansaetze sind vorhanden , der Weg ist allerdings noch weit , steinig und schwierig .
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[ "umlsterm" ]
5-aza-2'-deoxycytidine is a CHEMICAL, fetal hemoglobin is a GENE-N, Fetal hemoglobin is a GENE-N, HbF is a GENE-N, sickle hemoglobin is a GENE-N, HbS is a GENE-N, gamma - globin is a GENE-N, HbF is a GENE-N, cytosine is a CHEMICAL, 5-aza-2'-deoxycytidine is a CHEMICAL, decitabine is a CHEMICAL, DNA methyltransferase is a GENE-N, decitabine is a CHEMICAL, HbF is a GENE-N, hydroxyurea is a CHEMICAL, decitabine is a CHEMICAL, HbF is a GENE-N, hemoglobin is a GENE-N, gamma - Globin gene promoter is a GENE-N, decitabine is a CHEMICAL, HbF is a GENE-N, hemoglobin is a GENE-N, hemoglobin F is a GENE-N, hemoglobin is a GENE-N
17312_task0
Sentence: Effects of 5-aza-2'-deoxycytidine on fetal hemoglobin levels, red cell adhesion, and hematopoietic differentiation in patients with sickle cell disease. Fetal hemoglobin (HbF) decreases polymerization of sickle hemoglobin (HbS) and improves outcomes in sickle cell disease (SSD). Therefore, a therapeutic goal in SSD is pharmacologic reactivation of HbF. Silencing of the gamma-globin (HbF) gene is associated with DNA methylation. The cytosine analog 5-aza-2'-deoxycytidine (decitabine) hypomethylates DNA by inhibiting DNA methyltransferase. We examined if subcutaneous decitabine could increase HbF levels and improve SSD pathophysiology without cytotoxicity. Eight symptomatic SSD patients resistant or intolerant of standard treatment with hydroxyurea received decitabine 0.2 mg/kg subcutaneously 1 to 3 times per week in 2 cycles of 6-week duration. Treatment decreased neutrophils and increased mean HbF (6.5% to 20.4%, P <.0001) and mean total hemoglobin (76 to 96 g/L [7.6 to 9.6 g/dL], P <.001). Features of vaso-occlusive crisis pathophysiology such as red cell adhesion, endothelial damage, and coagulation pathway activity significantly improved. gamma-Globin gene promoter methylation decreased, and platelets and the proportion of megakaryocytes and erythroid cells in the marrow increased without a decrease in marrow cellularity, consistent with a DNA hypomethylating, noncytotoxic mechanism of action. Weekly subcutaneous decitabine produces cumulative increases in HbF and total hemoglobin through a noncytotoxic mechanism of action. Chronic dosing and sustained increases in hemoglobin F and total hemoglobin levels may be possible. Further studies in SSD and thalassemia are indicated. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N, CHEMICAL
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Effects of 5-aza-2'-deoxycytidine on fetal hemoglobin levels, red cell adhesion, and hematopoietic differentiation in patients with sickle cell disease. Fetal hemoglobin (HbF) decreases polymerization of sickle hemoglobin (HbS) and improves outcomes in sickle cell disease (SSD). Therefore, a therapeutic goal in SSD is pharmacologic reactivation of HbF. Silencing of the gamma-globin (HbF) gene is associated with DNA methylation. The cytosine analog 5-aza-2'-deoxycytidine (decitabine) hypomethylates DNA by inhibiting DNA methyltransferase. We examined if subcutaneous decitabine could increase HbF levels and improve SSD pathophysiology without cytotoxicity. Eight symptomatic SSD patients resistant or intolerant of standard treatment with hydroxyurea received decitabine 0.2 mg/kg subcutaneously 1 to 3 times per week in 2 cycles of 6-week duration. Treatment decreased neutrophils and increased mean HbF (6.5% to 20.4%, P <.0001) and mean total hemoglobin (76 to 96 g/L [7.6 to 9.6 g/dL], P <.001). Features of vaso-occlusive crisis pathophysiology such as red cell adhesion, endothelial damage, and coagulation pathway activity significantly improved. gamma-Globin gene promoter methylation decreased, and platelets and the proportion of megakaryocytes and erythroid cells in the marrow increased without a decrease in marrow cellularity, consistent with a DNA hypomethylating, noncytotoxic mechanism of action. Weekly subcutaneous decitabine produces cumulative increases in HbF and total hemoglobin through a noncytotoxic mechanism of action. Chronic dosing and sustained increases in hemoglobin F and total hemoglobin levels may be possible. Further studies in SSD and thalassemia are indicated.
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[ "GENE-N", "CHEMICAL" ]
5-aza-2'-deoxycytidine is a CHEMICAL, fetal hemoglobin is a GENE-N, Fetal hemoglobin is a GENE-N, HbF is a GENE-N, sickle hemoglobin is a GENE-N, HbS is a GENE-N, gamma - globin is a GENE-N, HbF is a GENE-N, cytosine is a CHEMICAL, 5-aza-2'-deoxycytidine is a CHEMICAL, decitabine is a CHEMICAL, DNA methyltransferase is a GENE-N, decitabine is a CHEMICAL, HbF is a GENE-N, hydroxyurea is a CHEMICAL, decitabine is a CHEMICAL, HbF is a GENE-N, hemoglobin is a GENE-N, gamma - Globin gene promoter is a GENE-N, decitabine is a CHEMICAL, HbF is a GENE-N, hemoglobin is a GENE-N, hemoglobin F is a GENE-N, hemoglobin is a GENE-N
17312_task1
Sentence: Effects of 5-aza-2'-deoxycytidine on fetal hemoglobin levels, red cell adhesion, and hematopoietic differentiation in patients with sickle cell disease. Fetal hemoglobin (HbF) decreases polymerization of sickle hemoglobin (HbS) and improves outcomes in sickle cell disease (SSD). Therefore, a therapeutic goal in SSD is pharmacologic reactivation of HbF. Silencing of the gamma-globin (HbF) gene is associated with DNA methylation. The cytosine analog 5-aza-2'-deoxycytidine (decitabine) hypomethylates DNA by inhibiting DNA methyltransferase. We examined if subcutaneous decitabine could increase HbF levels and improve SSD pathophysiology without cytotoxicity. Eight symptomatic SSD patients resistant or intolerant of standard treatment with hydroxyurea received decitabine 0.2 mg/kg subcutaneously 1 to 3 times per week in 2 cycles of 6-week duration. Treatment decreased neutrophils and increased mean HbF (6.5% to 20.4%, P <.0001) and mean total hemoglobin (76 to 96 g/L [7.6 to 9.6 g/dL], P <.001). Features of vaso-occlusive crisis pathophysiology such as red cell adhesion, endothelial damage, and coagulation pathway activity significantly improved. gamma-Globin gene promoter methylation decreased, and platelets and the proportion of megakaryocytes and erythroid cells in the marrow increased without a decrease in marrow cellularity, consistent with a DNA hypomethylating, noncytotoxic mechanism of action. Weekly subcutaneous decitabine produces cumulative increases in HbF and total hemoglobin through a noncytotoxic mechanism of action. Chronic dosing and sustained increases in hemoglobin F and total hemoglobin levels may be possible. Further studies in SSD and thalassemia are indicated. Instructions: please typing these entity words according to sentence: 5-aza-2'-deoxycytidine, fetal hemoglobin, Fetal hemoglobin, HbF, sickle hemoglobin, HbS, gamma - globin, HbF, cytosine, 5-aza-2'-deoxycytidine, decitabine, DNA methyltransferase, decitabine, HbF, hydroxyurea, decitabine, HbF, hemoglobin, gamma - Globin gene promoter, decitabine, HbF, hemoglobin, hemoglobin F, hemoglobin Options: GENE-N, CHEMICAL
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Effects of 5-aza-2'-deoxycytidine on fetal hemoglobin levels, red cell adhesion, and hematopoietic differentiation in patients with sickle cell disease. Fetal hemoglobin (HbF) decreases polymerization of sickle hemoglobin (HbS) and improves outcomes in sickle cell disease (SSD). Therefore, a therapeutic goal in SSD is pharmacologic reactivation of HbF. Silencing of the gamma-globin (HbF) gene is associated with DNA methylation. The cytosine analog 5-aza-2'-deoxycytidine (decitabine) hypomethylates DNA by inhibiting DNA methyltransferase. We examined if subcutaneous decitabine could increase HbF levels and improve SSD pathophysiology without cytotoxicity. Eight symptomatic SSD patients resistant or intolerant of standard treatment with hydroxyurea received decitabine 0.2 mg/kg subcutaneously 1 to 3 times per week in 2 cycles of 6-week duration. Treatment decreased neutrophils and increased mean HbF (6.5% to 20.4%, P <.0001) and mean total hemoglobin (76 to 96 g/L [7.6 to 9.6 g/dL], P <.001). Features of vaso-occlusive crisis pathophysiology such as red cell adhesion, endothelial damage, and coagulation pathway activity significantly improved. gamma-Globin gene promoter methylation decreased, and platelets and the proportion of megakaryocytes and erythroid cells in the marrow increased without a decrease in marrow cellularity, consistent with a DNA hypomethylating, noncytotoxic mechanism of action. Weekly subcutaneous decitabine produces cumulative increases in HbF and total hemoglobin through a noncytotoxic mechanism of action. Chronic dosing and sustained increases in hemoglobin F and total hemoglobin levels may be possible. Further studies in SSD and thalassemia are indicated.
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[ "GENE-N", "CHEMICAL" ]
5-aza-2'-deoxycytidine, fetal hemoglobin, Fetal hemoglobin, HbF, sickle hemoglobin, HbS, gamma - globin, HbF, cytosine, 5-aza-2'-deoxycytidine, decitabine, DNA methyltransferase, decitabine, HbF, hydroxyurea, decitabine, HbF, hemoglobin, gamma - Globin gene promoter, decitabine, HbF, hemoglobin, hemoglobin F, hemoglobin
17312_task2
Sentence: Effects of 5-aza-2'-deoxycytidine on fetal hemoglobin levels, red cell adhesion, and hematopoietic differentiation in patients with sickle cell disease. Fetal hemoglobin (HbF) decreases polymerization of sickle hemoglobin (HbS) and improves outcomes in sickle cell disease (SSD). Therefore, a therapeutic goal in SSD is pharmacologic reactivation of HbF. Silencing of the gamma-globin (HbF) gene is associated with DNA methylation. The cytosine analog 5-aza-2'-deoxycytidine (decitabine) hypomethylates DNA by inhibiting DNA methyltransferase. We examined if subcutaneous decitabine could increase HbF levels and improve SSD pathophysiology without cytotoxicity. Eight symptomatic SSD patients resistant or intolerant of standard treatment with hydroxyurea received decitabine 0.2 mg/kg subcutaneously 1 to 3 times per week in 2 cycles of 6-week duration. Treatment decreased neutrophils and increased mean HbF (6.5% to 20.4%, P <.0001) and mean total hemoglobin (76 to 96 g/L [7.6 to 9.6 g/dL], P <.001). Features of vaso-occlusive crisis pathophysiology such as red cell adhesion, endothelial damage, and coagulation pathway activity significantly improved. gamma-Globin gene promoter methylation decreased, and platelets and the proportion of megakaryocytes and erythroid cells in the marrow increased without a decrease in marrow cellularity, consistent with a DNA hypomethylating, noncytotoxic mechanism of action. Weekly subcutaneous decitabine produces cumulative increases in HbF and total hemoglobin through a noncytotoxic mechanism of action. Chronic dosing and sustained increases in hemoglobin F and total hemoglobin levels may be possible. Further studies in SSD and thalassemia are indicated. Instructions: please extract entity words from the input sentence
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Effects of 5-aza-2'-deoxycytidine on fetal hemoglobin levels, red cell adhesion, and hematopoietic differentiation in patients with sickle cell disease. Fetal hemoglobin (HbF) decreases polymerization of sickle hemoglobin (HbS) and improves outcomes in sickle cell disease (SSD). Therefore, a therapeutic goal in SSD is pharmacologic reactivation of HbF. Silencing of the gamma-globin (HbF) gene is associated with DNA methylation. The cytosine analog 5-aza-2'-deoxycytidine (decitabine) hypomethylates DNA by inhibiting DNA methyltransferase. We examined if subcutaneous decitabine could increase HbF levels and improve SSD pathophysiology without cytotoxicity. Eight symptomatic SSD patients resistant or intolerant of standard treatment with hydroxyurea received decitabine 0.2 mg/kg subcutaneously 1 to 3 times per week in 2 cycles of 6-week duration. Treatment decreased neutrophils and increased mean HbF (6.5% to 20.4%, P <.0001) and mean total hemoglobin (76 to 96 g/L [7.6 to 9.6 g/dL], P <.001). Features of vaso-occlusive crisis pathophysiology such as red cell adhesion, endothelial damage, and coagulation pathway activity significantly improved. gamma-Globin gene promoter methylation decreased, and platelets and the proportion of megakaryocytes and erythroid cells in the marrow increased without a decrease in marrow cellularity, consistent with a DNA hypomethylating, noncytotoxic mechanism of action. Weekly subcutaneous decitabine produces cumulative increases in HbF and total hemoglobin through a noncytotoxic mechanism of action. Chronic dosing and sustained increases in hemoglobin F and total hemoglobin levels may be possible. Further studies in SSD and thalassemia are indicated.
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[ "GENE-N", "CHEMICAL" ]
Dopamine D(2 ) receptor is a GENE-Y, prostaglandin E(2 ) is a CHEMICAL, prostaglandin E(2 ) is a CHEMICAL, PGE(2 ) is a CHEMICAL, arachidonic acid is a CHEMICAL, rat dopamine D(2 ) receptor ( long isoform ) is a GENE-Y, dopamine is a CHEMICAL, PGE(2 ) is a CHEMICAL, D(2 ) is a GENE-Y, eticlopride is a CHEMICAL, pertussis toxin is a GENE-N, Ca(2 + ) is a CHEMICAL, PKC is a GENE-N, cyclooxygenase is a GENE-N, COX is a GENE-N, indomethacin is a CHEMICAL, COX-2 is a GENE-Y, NS-398 is a CHEMICAL, COX-1 is a GENE-Y, valeryl salicylate is a CHEMICAL, phospholipase A(2 ) is a GENE-Y, quinacrine is a CHEMICAL, cPLA(2 ) is a GENE-Y, iPLA(2 ) is a GENE-Y, iPLA(2 ) is a GENE-Y, sPLA(2 ) is a GENE-N, dopamine is a CHEMICAL, dopamine is a CHEMICAL, eicosanoid is a CHEMICAL, D(2 ) receptor is a GENE-Y, cPLA(2 ) is a GENE-Y, COX-2 is a GENE-Y, dopamine is a CHEMICAL, D(2 ) receptor is a GENE-Y
937_task0
Sentence: Dopamine D(2) receptor-induced COX-2-mediated production of prostaglandin E(2) in D(2)-transfected Chinese hamster ovary cells without simultaneous administration of a Ca(2+)-mobilizing agent. We have earlier demonstrated that dopamine stimulates the liberation of the prostaglandin E(2) (PGE(2)) precursor, arachidonic acid, in Chinese hamster ovary cells transfected with the rat dopamine D(2) receptor (long isoform), also without concomitant administration of a Ca(2+)-releasing agent [Nilsson et al., Br J Pharmacol 1998;124:1651-8]. In the present report, we show that dopamine, under the same conditions, also induces a concentration-dependent increase in the production of PGE(2), with a maximal effect of 235% at approximately 100 microM, and with an EC(50) of 794 nM. The effect was counteracted by the D(2) antagonist eticlopride, pertussis toxin, the inhibitor of intracellular Ca(2+) release TMB-8, incubation in Ca(2+)-free experimental medium, and PKC desensitization obtained by chronic pretreatment with the phorbol ester TPA. It was also antagonized by the non-specific cyclooxygenase (COX) inhibitor, indomethacin, and by the selective COX-2 inhibitor, NS-398, but not by the specific COX-1 inhibitor, valeryl salicylate. Both the non-specific phospholipase A(2) inhibitor, quinacrine, and an inhibitor of cPLA(2) and iPLA(2), AACOF3, counteracted the effect; in contrast, a selective iPLA(2) inhibitor, BEL, and a selective sPLA(2) inhibitor, TAPC, were ineffective. No effects of dopamine were obtained in control cells mock-transfected with the p3C vector only. The results reinforce previous assumptions that dopamine may interact with eicosanoid metabolism by means of D(2) receptor activation, and implicate an involvement of cPLA(2) and COX-2 in this effect. It is suggested that measurement of dopamine-induced PGE(2) production may serve as a convenient way to study D(2) receptor function in vitro. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N, GENE-Y, CHEMICAL
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Dopamine D(2) receptor-induced COX-2-mediated production of prostaglandin E(2) in D(2)-transfected Chinese hamster ovary cells without simultaneous administration of a Ca(2+)-mobilizing agent. We have earlier demonstrated that dopamine stimulates the liberation of the prostaglandin E(2) (PGE(2)) precursor, arachidonic acid, in Chinese hamster ovary cells transfected with the rat dopamine D(2) receptor (long isoform), also without concomitant administration of a Ca(2+)-releasing agent [Nilsson et al., Br J Pharmacol 1998;124:1651-8]. In the present report, we show that dopamine, under the same conditions, also induces a concentration-dependent increase in the production of PGE(2), with a maximal effect of 235% at approximately 100 microM, and with an EC(50) of 794 nM. The effect was counteracted by the D(2) antagonist eticlopride, pertussis toxin, the inhibitor of intracellular Ca(2+) release TMB-8, incubation in Ca(2+)-free experimental medium, and PKC desensitization obtained by chronic pretreatment with the phorbol ester TPA. It was also antagonized by the non-specific cyclooxygenase (COX) inhibitor, indomethacin, and by the selective COX-2 inhibitor, NS-398, but not by the specific COX-1 inhibitor, valeryl salicylate. Both the non-specific phospholipase A(2) inhibitor, quinacrine, and an inhibitor of cPLA(2) and iPLA(2), AACOF3, counteracted the effect; in contrast, a selective iPLA(2) inhibitor, BEL, and a selective sPLA(2) inhibitor, TAPC, were ineffective. No effects of dopamine were obtained in control cells mock-transfected with the p3C vector only. The results reinforce previous assumptions that dopamine may interact with eicosanoid metabolism by means of D(2) receptor activation, and implicate an involvement of cPLA(2) and COX-2 in this effect. It is suggested that measurement of dopamine-induced PGE(2) production may serve as a convenient way to study D(2) receptor function in vitro.
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[ "GENE-Y", "CHEMICAL", "GENE-N" ]
Dopamine D(2 ) receptor is a GENE-Y, prostaglandin E(2 ) is a CHEMICAL, prostaglandin E(2 ) is a CHEMICAL, PGE(2 ) is a CHEMICAL, arachidonic acid is a CHEMICAL, rat dopamine D(2 ) receptor ( long isoform ) is a GENE-Y, dopamine is a CHEMICAL, PGE(2 ) is a CHEMICAL, D(2 ) is a GENE-Y, eticlopride is a CHEMICAL, pertussis toxin is a GENE-N, Ca(2 + ) is a CHEMICAL, PKC is a GENE-N, cyclooxygenase is a GENE-N, COX is a GENE-N, indomethacin is a CHEMICAL, COX-2 is a GENE-Y, NS-398 is a CHEMICAL, COX-1 is a GENE-Y, valeryl salicylate is a CHEMICAL, phospholipase A(2 ) is a GENE-Y, quinacrine is a CHEMICAL, cPLA(2 ) is a GENE-Y, iPLA(2 ) is a GENE-Y, iPLA(2 ) is a GENE-Y, sPLA(2 ) is a GENE-N, dopamine is a CHEMICAL, dopamine is a CHEMICAL, eicosanoid is a CHEMICAL, D(2 ) receptor is a GENE-Y, cPLA(2 ) is a GENE-Y, COX-2 is a GENE-Y, dopamine is a CHEMICAL, D(2 ) receptor is a GENE-Y
937_task1
Sentence: Dopamine D(2) receptor-induced COX-2-mediated production of prostaglandin E(2) in D(2)-transfected Chinese hamster ovary cells without simultaneous administration of a Ca(2+)-mobilizing agent. We have earlier demonstrated that dopamine stimulates the liberation of the prostaglandin E(2) (PGE(2)) precursor, arachidonic acid, in Chinese hamster ovary cells transfected with the rat dopamine D(2) receptor (long isoform), also without concomitant administration of a Ca(2+)-releasing agent [Nilsson et al., Br J Pharmacol 1998;124:1651-8]. In the present report, we show that dopamine, under the same conditions, also induces a concentration-dependent increase in the production of PGE(2), with a maximal effect of 235% at approximately 100 microM, and with an EC(50) of 794 nM. The effect was counteracted by the D(2) antagonist eticlopride, pertussis toxin, the inhibitor of intracellular Ca(2+) release TMB-8, incubation in Ca(2+)-free experimental medium, and PKC desensitization obtained by chronic pretreatment with the phorbol ester TPA. It was also antagonized by the non-specific cyclooxygenase (COX) inhibitor, indomethacin, and by the selective COX-2 inhibitor, NS-398, but not by the specific COX-1 inhibitor, valeryl salicylate. Both the non-specific phospholipase A(2) inhibitor, quinacrine, and an inhibitor of cPLA(2) and iPLA(2), AACOF3, counteracted the effect; in contrast, a selective iPLA(2) inhibitor, BEL, and a selective sPLA(2) inhibitor, TAPC, were ineffective. No effects of dopamine were obtained in control cells mock-transfected with the p3C vector only. The results reinforce previous assumptions that dopamine may interact with eicosanoid metabolism by means of D(2) receptor activation, and implicate an involvement of cPLA(2) and COX-2 in this effect. It is suggested that measurement of dopamine-induced PGE(2) production may serve as a convenient way to study D(2) receptor function in vitro. Instructions: please typing these entity words according to sentence: Dopamine D(2 ) receptor, prostaglandin E(2 ), prostaglandin E(2 ), PGE(2 ), arachidonic acid, rat dopamine D(2 ) receptor ( long isoform ), dopamine, PGE(2 ), D(2 ), eticlopride, pertussis toxin, Ca(2 + ), PKC, cyclooxygenase, COX, indomethacin, COX-2, NS-398, COX-1, valeryl salicylate, phospholipase A(2 ), quinacrine, cPLA(2 ), iPLA(2 ), iPLA(2 ), sPLA(2 ), dopamine, dopamine, eicosanoid, D(2 ) receptor, cPLA(2 ), COX-2, dopamine, D(2 ) receptor Options: GENE-N, GENE-Y, CHEMICAL
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Dopamine D(2) receptor-induced COX-2-mediated production of prostaglandin E(2) in D(2)-transfected Chinese hamster ovary cells without simultaneous administration of a Ca(2+)-mobilizing agent. We have earlier demonstrated that dopamine stimulates the liberation of the prostaglandin E(2) (PGE(2)) precursor, arachidonic acid, in Chinese hamster ovary cells transfected with the rat dopamine D(2) receptor (long isoform), also without concomitant administration of a Ca(2+)-releasing agent [Nilsson et al., Br J Pharmacol 1998;124:1651-8]. In the present report, we show that dopamine, under the same conditions, also induces a concentration-dependent increase in the production of PGE(2), with a maximal effect of 235% at approximately 100 microM, and with an EC(50) of 794 nM. The effect was counteracted by the D(2) antagonist eticlopride, pertussis toxin, the inhibitor of intracellular Ca(2+) release TMB-8, incubation in Ca(2+)-free experimental medium, and PKC desensitization obtained by chronic pretreatment with the phorbol ester TPA. It was also antagonized by the non-specific cyclooxygenase (COX) inhibitor, indomethacin, and by the selective COX-2 inhibitor, NS-398, but not by the specific COX-1 inhibitor, valeryl salicylate. Both the non-specific phospholipase A(2) inhibitor, quinacrine, and an inhibitor of cPLA(2) and iPLA(2), AACOF3, counteracted the effect; in contrast, a selective iPLA(2) inhibitor, BEL, and a selective sPLA(2) inhibitor, TAPC, were ineffective. No effects of dopamine were obtained in control cells mock-transfected with the p3C vector only. The results reinforce previous assumptions that dopamine may interact with eicosanoid metabolism by means of D(2) receptor activation, and implicate an involvement of cPLA(2) and COX-2 in this effect. It is suggested that measurement of dopamine-induced PGE(2) production may serve as a convenient way to study D(2) receptor function in vitro.
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[ "GENE-Y", "CHEMICAL", "GENE-N" ]
Dopamine D(2 ) receptor, prostaglandin E(2 ), prostaglandin E(2 ), PGE(2 ), arachidonic acid, rat dopamine D(2 ) receptor ( long isoform ), dopamine, PGE(2 ), D(2 ), eticlopride, pertussis toxin, Ca(2 + ), PKC, cyclooxygenase, COX, indomethacin, COX-2, NS-398, COX-1, valeryl salicylate, phospholipase A(2 ), quinacrine, cPLA(2 ), iPLA(2 ), iPLA(2 ), sPLA(2 ), dopamine, dopamine, eicosanoid, D(2 ) receptor, cPLA(2 ), COX-2, dopamine, D(2 ) receptor
937_task2
Sentence: Dopamine D(2) receptor-induced COX-2-mediated production of prostaglandin E(2) in D(2)-transfected Chinese hamster ovary cells without simultaneous administration of a Ca(2+)-mobilizing agent. We have earlier demonstrated that dopamine stimulates the liberation of the prostaglandin E(2) (PGE(2)) precursor, arachidonic acid, in Chinese hamster ovary cells transfected with the rat dopamine D(2) receptor (long isoform), also without concomitant administration of a Ca(2+)-releasing agent [Nilsson et al., Br J Pharmacol 1998;124:1651-8]. In the present report, we show that dopamine, under the same conditions, also induces a concentration-dependent increase in the production of PGE(2), with a maximal effect of 235% at approximately 100 microM, and with an EC(50) of 794 nM. The effect was counteracted by the D(2) antagonist eticlopride, pertussis toxin, the inhibitor of intracellular Ca(2+) release TMB-8, incubation in Ca(2+)-free experimental medium, and PKC desensitization obtained by chronic pretreatment with the phorbol ester TPA. It was also antagonized by the non-specific cyclooxygenase (COX) inhibitor, indomethacin, and by the selective COX-2 inhibitor, NS-398, but not by the specific COX-1 inhibitor, valeryl salicylate. Both the non-specific phospholipase A(2) inhibitor, quinacrine, and an inhibitor of cPLA(2) and iPLA(2), AACOF3, counteracted the effect; in contrast, a selective iPLA(2) inhibitor, BEL, and a selective sPLA(2) inhibitor, TAPC, were ineffective. No effects of dopamine were obtained in control cells mock-transfected with the p3C vector only. The results reinforce previous assumptions that dopamine may interact with eicosanoid metabolism by means of D(2) receptor activation, and implicate an involvement of cPLA(2) and COX-2 in this effect. It is suggested that measurement of dopamine-induced PGE(2) production may serve as a convenient way to study D(2) receptor function in vitro. Instructions: please extract entity words from the input sentence
[ "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "B-CHEMICAL", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "B-GENE-N", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O" ]
Dopamine D(2) receptor-induced COX-2-mediated production of prostaglandin E(2) in D(2)-transfected Chinese hamster ovary cells without simultaneous administration of a Ca(2+)-mobilizing agent. We have earlier demonstrated that dopamine stimulates the liberation of the prostaglandin E(2) (PGE(2)) precursor, arachidonic acid, in Chinese hamster ovary cells transfected with the rat dopamine D(2) receptor (long isoform), also without concomitant administration of a Ca(2+)-releasing agent [Nilsson et al., Br J Pharmacol 1998;124:1651-8]. In the present report, we show that dopamine, under the same conditions, also induces a concentration-dependent increase in the production of PGE(2), with a maximal effect of 235% at approximately 100 microM, and with an EC(50) of 794 nM. The effect was counteracted by the D(2) antagonist eticlopride, pertussis toxin, the inhibitor of intracellular Ca(2+) release TMB-8, incubation in Ca(2+)-free experimental medium, and PKC desensitization obtained by chronic pretreatment with the phorbol ester TPA. It was also antagonized by the non-specific cyclooxygenase (COX) inhibitor, indomethacin, and by the selective COX-2 inhibitor, NS-398, but not by the specific COX-1 inhibitor, valeryl salicylate. Both the non-specific phospholipase A(2) inhibitor, quinacrine, and an inhibitor of cPLA(2) and iPLA(2), AACOF3, counteracted the effect; in contrast, a selective iPLA(2) inhibitor, BEL, and a selective sPLA(2) inhibitor, TAPC, were ineffective. No effects of dopamine were obtained in control cells mock-transfected with the p3C vector only. The results reinforce previous assumptions that dopamine may interact with eicosanoid metabolism by means of D(2) receptor activation, and implicate an involvement of cPLA(2) and COX-2 in this effect. It is suggested that measurement of dopamine-induced PGE(2) production may serve as a convenient way to study D(2) receptor function in vitro.
[ "Dopamine", "D(2", ")", "receptor", "-", "induced", "COX-2-mediated", "production", "of", "prostaglandin", "E(2", ")", "in", "D(2)-transfected", "Chinese", "hamster", "ovary", "cells", "without", "simultaneous", "administration", "of", "a", "Ca(2+)-mobilizing", "agent", ".", "\n", "We", "have", "earlier", "demonstrated", "that", "dopamine", "stimulates", "the", "liberation", "of", "the", "prostaglandin", "E(2", ")", "(", "PGE(2", ")", ")", "precursor", ",", "arachidonic", "acid", ",", "in", "Chinese", "hamster", "ovary", "cells", "transfected", "with", "the", "rat", "dopamine", "D(2", ")", "receptor", "(", "long", "isoform", ")", ",", "also", "without", "concomitant", "administration", "of", "a", "Ca(2+)-releasing", "agent", "[", "Nilsson", "et", "al", ".", ",", "Br", "J", "Pharmacol", "1998;124:1651", "-", "8", "]", ".", "In", "the", "present", "report", ",", "we", "show", "that", "dopamine", ",", "under", "the", "same", "conditions", ",", "also", "induces", "a", "concentration", "-", "dependent", "increase", "in", "the", "production", "of", "PGE(2", ")", ",", "with", "a", "maximal", "effect", "of", "235", "%", "at", "approximately", "100", "microM", ",", "and", "with", "an", "EC(50", ")", "of", "794", "nM.", "The", "effect", "was", "counteracted", "by", "the", "D(2", ")", "antagonist", "eticlopride", ",", "pertussis", "toxin", ",", "the", "inhibitor", "of", "intracellular", "Ca(2", "+", ")", "release", "TMB-8", ",", "incubation", "in", "Ca(2+)-free", "experimental", "medium", ",", "and", "PKC", "desensitization", "obtained", "by", "chronic", "pretreatment", "with", "the", "phorbol", "ester", "TPA", ".", "It", "was", "also", "antagonized", "by", "the", "non", "-", "specific", "cyclooxygenase", "(", "COX", ")", "inhibitor", ",", "indomethacin", ",", "and", "by", "the", "selective", "COX-2", "inhibitor", ",", "NS-398", ",", "but", "not", "by", "the", "specific", "COX-1", "inhibitor", ",", "valeryl", "salicylate", ".", "Both", "the", "non", "-", "specific", "phospholipase", "A(2", ")", "inhibitor", ",", "quinacrine", ",", "and", "an", "inhibitor", "of", "cPLA(2", ")", "and", "iPLA(2", ")", ",", "AACOF3", ",", "counteracted", "the", "effect", ";", "in", "contrast", ",", "a", "selective", "iPLA(2", ")", "inhibitor", ",", "BEL", ",", "and", "a", "selective", "sPLA(2", ")", "inhibitor", ",", "TAPC", ",", "were", "ineffective", ".", "No", "effects", "of", "dopamine", "were", "obtained", "in", "control", "cells", "mock", "-", "transfected", "with", "the", "p3C", "vector", "only", ".", "The", "results", "reinforce", "previous", "assumptions", "that", "dopamine", "may", "interact", "with", "eicosanoid", "metabolism", "by", "means", "of", "D(2", ")", "receptor", "activation", ",", "and", "implicate", "an", "involvement", "of", "cPLA(2", ")", "and", "COX-2", "in", "this", "effect", ".", "It", "is", "suggested", "that", "measurement", "of", "dopamine", "-", "induced", "PGE(2", ")", "production", "may", "serve", "as", "a", "convenient", "way", "to", "study", "D(2", ")", "receptor", "function", "in", "vitro", "." ]
[ "GENE-Y", "CHEMICAL", "GENE-N" ]
NRG-1 is a protein, kainate is a compound, carbachol is a compound
DS.d542_task0
Sentence: Here we show that NRG-1 selectively increases the power of kainate-induced, but not carbachol-induced, gamma oscillations in acute hippocampal slices. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein
[ "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Here we show that NRG-1 selectively increases the power of kainate-induced, but not carbachol-induced, gamma oscillations in acute hippocampal slices.
[ "Here", "we", "show", "that", "NRG-1", "selectively", "increases", "the", "power", "of", "kainate", "-", "induced", ",", "but", "not", "carbachol", "-", "induced", ",", "gamma", "oscillations", "in", "acute", "hippocampal", "slices", "." ]
[ "compound", "protein" ]
NRG-1 is a protein, kainate is a compound, carbachol is a compound
DS.d542_task1
Sentence: Here we show that NRG-1 selectively increases the power of kainate-induced, but not carbachol-induced, gamma oscillations in acute hippocampal slices. Instructions: please typing these entity words according to sentence: NRG-1, kainate, carbachol Options: compound, protein
[ "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Here we show that NRG-1 selectively increases the power of kainate-induced, but not carbachol-induced, gamma oscillations in acute hippocampal slices.
[ "Here", "we", "show", "that", "NRG-1", "selectively", "increases", "the", "power", "of", "kainate", "-", "induced", ",", "but", "not", "carbachol", "-", "induced", ",", "gamma", "oscillations", "in", "acute", "hippocampal", "slices", "." ]
[ "compound", "protein" ]
NRG-1, kainate, carbachol
DS.d542_task2
Sentence: Here we show that NRG-1 selectively increases the power of kainate-induced, but not carbachol-induced, gamma oscillations in acute hippocampal slices. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Here we show that NRG-1 selectively increases the power of kainate-induced, but not carbachol-induced, gamma oscillations in acute hippocampal slices.
[ "Here", "we", "show", "that", "NRG-1", "selectively", "increases", "the", "power", "of", "kainate", "-", "induced", ",", "but", "not", "carbachol", "-", "induced", ",", "gamma", "oscillations", "in", "acute", "hippocampal", "slices", "." ]
[ "compound", "protein" ]
fascin is a protein, beta - catenin is a protein-family, LLC - PK1 cells is a cell, fascin is a protein
1.0alpha7.train.886_task0
Sentence: This result suggests that the binding between fascin and beta-catenin may not be significant in these cell lines, LLC-PK1 cells, and fascin transfectants. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: protein-family, cell, protein
[ "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein-family", "I-protein-family", "I-protein-family", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-cell", "I-cell", "I-cell", "I-cell", "O", "O", "O", "B-protein", "O", "O" ]
This result suggests that the binding between fascin and beta-catenin may not be significant in these cell lines, LLC-PK1 cells, and fascin transfectants.
[ "This", "result", "suggests", "that", "the", "binding", "between", " ", "fascin", "and", " ", "beta", "-", "catenin", "may", "not", "be", "significant", "in", "these", "cell", "lines", ",", " ", "LLC", "-", "PK1", "cells", ",", "and", " ", "fascin", "transfectants", "." ]
[ "cell", "protein-family", "protein" ]
fascin is a protein, beta - catenin is a protein-family, LLC - PK1 cells is a cell, fascin is a protein
1.0alpha7.train.886_task1
Sentence: This result suggests that the binding between fascin and beta-catenin may not be significant in these cell lines, LLC-PK1 cells, and fascin transfectants. Instructions: please typing these entity words according to sentence: fascin, beta - catenin, LLC - PK1 cells, fascin Options: protein-family, cell, protein
[ "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein-family", "I-protein-family", "I-protein-family", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-cell", "I-cell", "I-cell", "I-cell", "O", "O", "O", "B-protein", "O", "O" ]
This result suggests that the binding between fascin and beta-catenin may not be significant in these cell lines, LLC-PK1 cells, and fascin transfectants.
[ "This", "result", "suggests", "that", "the", "binding", "between", " ", "fascin", "and", " ", "beta", "-", "catenin", "may", "not", "be", "significant", "in", "these", "cell", "lines", ",", " ", "LLC", "-", "PK1", "cells", ",", "and", " ", "fascin", "transfectants", "." ]
[ "cell", "protein-family", "protein" ]
fascin, beta - catenin, LLC - PK1 cells, fascin
1.0alpha7.train.886_task2
Sentence: This result suggests that the binding between fascin and beta-catenin may not be significant in these cell lines, LLC-PK1 cells, and fascin transfectants. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein-family", "I-protein-family", "I-protein-family", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-cell", "I-cell", "I-cell", "I-cell", "O", "O", "O", "B-protein", "O", "O" ]
This result suggests that the binding between fascin and beta-catenin may not be significant in these cell lines, LLC-PK1 cells, and fascin transfectants.
[ "This", "result", "suggests", "that", "the", "binding", "between", " ", "fascin", "and", " ", "beta", "-", "catenin", "may", "not", "be", "significant", "in", "these", "cell", "lines", ",", " ", "LLC", "-", "PK1", "cells", ",", "and", " ", "fascin", "transfectants", "." ]
[ "cell", "protein-family", "protein" ]
polycystic ovaries is a Participant_Condition, in - vitro fertilization . is a Outcome_Physical, in - vitro fertilization and embryo transfer ( IVF - ET ) is a Intervention_Physical, 76 is a Participant_Sample-size, PCO is a Participant_Condition, human menopausal gonadotrophin ( HMG ) is a Intervention_Physical, serum oestradiol levels is a Outcome_Physical, chorionic gonadotrophin is a Intervention_Physical, follicles is a Outcome_Physical, oocytes is a Outcome_Physical, fertilization rates is a Outcome_Physical, cleavage rates . is a Outcome_Physical, pregnancy rate / embryo transfer is a Outcome_Physical, group with normal ovaries is a Participant_Condition, ovarian hyperstimulation syndrome ( OHSS ) is a Outcome_Physical, pregnancy and livebirth rates . is a Outcome_Physical
86106_task0
Sentence: A controlled study comparing patients with and without polycystic ovaries undergoing in-vitro fertilization . The outcome of in-vitro fertilization and embryo transfer ( IVF-ET ) was compared in 76 patients with polycystic ovaries ( PCO ) diagnosed on pre-treatment ultrasound scan , and 76 control patients who had normal ovaries and were matched for age , cause of infertility and stimulation regimen . Despite receiving significantly less human menopausal gonadotrophin ( HMG ) , patients with PCO , as compared with controls , had significantly higher serum oestradiol levels on the day of human chorionic gonadotrophin administration ( 5940 +/- 255 versus 4370 +/- 240 pmol/l , P < 0.001 ) , developed more follicles ( 14.9 +/- 0.7 versus 9.8 +/- 0.6 , P < 0.001 ) and produced more oocytes ( 9.3 +/- 0.6 versus 6.8 +/- 0.5 , P = 0.003 ) . However , fertilization rates were reduced in the PCO patients ( 52.8 +/- 3.4 % versus 66.1 +/- 3.4 % , P = 0.007 ) . There was no significant difference in cleavage rates . The pregnancy rate/embryo transfer was 25.4 % in the PCO group and 23.0 % in the group with normal ovaries . There were three high order multiple pregnancies in the PCO group compared with none in the group with normal ovaries . Of the PCO patients , 10.5 % developed moderate/severe ovarian hyperstimulation syndrome ( OHSS ) compared with none of the controls ( P = 0.006 ) . Patients with and without PCO undergoing IVF have comparable pregnancy and livebirth rates . However , it is important to diagnose PCO before ovarian stimulation is initiated as these patients are more likely to develop moderate or severe OHSS following IVF-ET . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Physical, Outcome_Physical, Participant_Condition, Participant_Sample-size
[ "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "O", "O", "B-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
A controlled study comparing patients with and without polycystic ovaries undergoing in-vitro fertilization . The outcome of in-vitro fertilization and embryo transfer ( IVF-ET ) was compared in 76 patients with polycystic ovaries ( PCO ) diagnosed on pre-treatment ultrasound scan , and 76 control patients who had normal ovaries and were matched for age , cause of infertility and stimulation regimen . Despite receiving significantly less human menopausal gonadotrophin ( HMG ) , patients with PCO , as compared with controls , had significantly higher serum oestradiol levels on the day of human chorionic gonadotrophin administration ( 5940 +/- 255 versus 4370 +/- 240 pmol/l , P < 0.001 ) , developed more follicles ( 14.9 +/- 0.7 versus 9.8 +/- 0.6 , P < 0.001 ) and produced more oocytes ( 9.3 +/- 0.6 versus 6.8 +/- 0.5 , P = 0.003 ) . However , fertilization rates were reduced in the PCO patients ( 52.8 +/- 3.4 % versus 66.1 +/- 3.4 % , P = 0.007 ) . There was no significant difference in cleavage rates . The pregnancy rate/embryo transfer was 25.4 % in the PCO group and 23.0 % in the group with normal ovaries . There were three high order multiple pregnancies in the PCO group compared with none in the group with normal ovaries . Of the PCO patients , 10.5 % developed moderate/severe ovarian hyperstimulation syndrome ( OHSS ) compared with none of the controls ( P = 0.006 ) . Patients with and without PCO undergoing IVF have comparable pregnancy and livebirth rates . However , it is important to diagnose PCO before ovarian stimulation is initiated as these patients are more likely to develop moderate or severe OHSS following IVF-ET .
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[ "Intervention_Physical", "Outcome_Physical", "Participant_Condition", "Participant_Sample-size" ]
polycystic ovaries is a Participant_Condition, in - vitro fertilization . is a Outcome_Physical, in - vitro fertilization and embryo transfer ( IVF - ET ) is a Intervention_Physical, 76 is a Participant_Sample-size, PCO is a Participant_Condition, human menopausal gonadotrophin ( HMG ) is a Intervention_Physical, serum oestradiol levels is a Outcome_Physical, chorionic gonadotrophin is a Intervention_Physical, follicles is a Outcome_Physical, oocytes is a Outcome_Physical, fertilization rates is a Outcome_Physical, cleavage rates . is a Outcome_Physical, pregnancy rate / embryo transfer is a Outcome_Physical, group with normal ovaries is a Participant_Condition, ovarian hyperstimulation syndrome ( OHSS ) is a Outcome_Physical, pregnancy and livebirth rates . is a Outcome_Physical
86106_task1
Sentence: A controlled study comparing patients with and without polycystic ovaries undergoing in-vitro fertilization . The outcome of in-vitro fertilization and embryo transfer ( IVF-ET ) was compared in 76 patients with polycystic ovaries ( PCO ) diagnosed on pre-treatment ultrasound scan , and 76 control patients who had normal ovaries and were matched for age , cause of infertility and stimulation regimen . Despite receiving significantly less human menopausal gonadotrophin ( HMG ) , patients with PCO , as compared with controls , had significantly higher serum oestradiol levels on the day of human chorionic gonadotrophin administration ( 5940 +/- 255 versus 4370 +/- 240 pmol/l , P < 0.001 ) , developed more follicles ( 14.9 +/- 0.7 versus 9.8 +/- 0.6 , P < 0.001 ) and produced more oocytes ( 9.3 +/- 0.6 versus 6.8 +/- 0.5 , P = 0.003 ) . However , fertilization rates were reduced in the PCO patients ( 52.8 +/- 3.4 % versus 66.1 +/- 3.4 % , P = 0.007 ) . There was no significant difference in cleavage rates . The pregnancy rate/embryo transfer was 25.4 % in the PCO group and 23.0 % in the group with normal ovaries . There were three high order multiple pregnancies in the PCO group compared with none in the group with normal ovaries . Of the PCO patients , 10.5 % developed moderate/severe ovarian hyperstimulation syndrome ( OHSS ) compared with none of the controls ( P = 0.006 ) . Patients with and without PCO undergoing IVF have comparable pregnancy and livebirth rates . However , it is important to diagnose PCO before ovarian stimulation is initiated as these patients are more likely to develop moderate or severe OHSS following IVF-ET . Instructions: please typing these entity words according to sentence: polycystic ovaries, in - vitro fertilization ., in - vitro fertilization and embryo transfer ( IVF - ET ), 76, PCO, human menopausal gonadotrophin ( HMG ), serum oestradiol levels, chorionic gonadotrophin, follicles, oocytes, fertilization rates, cleavage rates ., pregnancy rate / embryo transfer, group with normal ovaries, ovarian hyperstimulation syndrome ( OHSS ), pregnancy and livebirth rates . Options: Intervention_Physical, Outcome_Physical, Participant_Condition, Participant_Sample-size
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A controlled study comparing patients with and without polycystic ovaries undergoing in-vitro fertilization . The outcome of in-vitro fertilization and embryo transfer ( IVF-ET ) was compared in 76 patients with polycystic ovaries ( PCO ) diagnosed on pre-treatment ultrasound scan , and 76 control patients who had normal ovaries and were matched for age , cause of infertility and stimulation regimen . Despite receiving significantly less human menopausal gonadotrophin ( HMG ) , patients with PCO , as compared with controls , had significantly higher serum oestradiol levels on the day of human chorionic gonadotrophin administration ( 5940 +/- 255 versus 4370 +/- 240 pmol/l , P < 0.001 ) , developed more follicles ( 14.9 +/- 0.7 versus 9.8 +/- 0.6 , P < 0.001 ) and produced more oocytes ( 9.3 +/- 0.6 versus 6.8 +/- 0.5 , P = 0.003 ) . However , fertilization rates were reduced in the PCO patients ( 52.8 +/- 3.4 % versus 66.1 +/- 3.4 % , P = 0.007 ) . There was no significant difference in cleavage rates . The pregnancy rate/embryo transfer was 25.4 % in the PCO group and 23.0 % in the group with normal ovaries . There were three high order multiple pregnancies in the PCO group compared with none in the group with normal ovaries . Of the PCO patients , 10.5 % developed moderate/severe ovarian hyperstimulation syndrome ( OHSS ) compared with none of the controls ( P = 0.006 ) . Patients with and without PCO undergoing IVF have comparable pregnancy and livebirth rates . However , it is important to diagnose PCO before ovarian stimulation is initiated as these patients are more likely to develop moderate or severe OHSS following IVF-ET .
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[ "Intervention_Physical", "Outcome_Physical", "Participant_Condition", "Participant_Sample-size" ]
polycystic ovaries, in - vitro fertilization ., in - vitro fertilization and embryo transfer ( IVF - ET ), 76, PCO, human menopausal gonadotrophin ( HMG ), serum oestradiol levels, chorionic gonadotrophin, follicles, oocytes, fertilization rates, cleavage rates ., pregnancy rate / embryo transfer, group with normal ovaries, ovarian hyperstimulation syndrome ( OHSS ), pregnancy and livebirth rates .
86106_task2
Sentence: A controlled study comparing patients with and without polycystic ovaries undergoing in-vitro fertilization . The outcome of in-vitro fertilization and embryo transfer ( IVF-ET ) was compared in 76 patients with polycystic ovaries ( PCO ) diagnosed on pre-treatment ultrasound scan , and 76 control patients who had normal ovaries and were matched for age , cause of infertility and stimulation regimen . Despite receiving significantly less human menopausal gonadotrophin ( HMG ) , patients with PCO , as compared with controls , had significantly higher serum oestradiol levels on the day of human chorionic gonadotrophin administration ( 5940 +/- 255 versus 4370 +/- 240 pmol/l , P < 0.001 ) , developed more follicles ( 14.9 +/- 0.7 versus 9.8 +/- 0.6 , P < 0.001 ) and produced more oocytes ( 9.3 +/- 0.6 versus 6.8 +/- 0.5 , P = 0.003 ) . However , fertilization rates were reduced in the PCO patients ( 52.8 +/- 3.4 % versus 66.1 +/- 3.4 % , P = 0.007 ) . There was no significant difference in cleavage rates . The pregnancy rate/embryo transfer was 25.4 % in the PCO group and 23.0 % in the group with normal ovaries . There were three high order multiple pregnancies in the PCO group compared with none in the group with normal ovaries . Of the PCO patients , 10.5 % developed moderate/severe ovarian hyperstimulation syndrome ( OHSS ) compared with none of the controls ( P = 0.006 ) . Patients with and without PCO undergoing IVF have comparable pregnancy and livebirth rates . However , it is important to diagnose PCO before ovarian stimulation is initiated as these patients are more likely to develop moderate or severe OHSS following IVF-ET . Instructions: please extract entity words from the input sentence
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A controlled study comparing patients with and without polycystic ovaries undergoing in-vitro fertilization . The outcome of in-vitro fertilization and embryo transfer ( IVF-ET ) was compared in 76 patients with polycystic ovaries ( PCO ) diagnosed on pre-treatment ultrasound scan , and 76 control patients who had normal ovaries and were matched for age , cause of infertility and stimulation regimen . Despite receiving significantly less human menopausal gonadotrophin ( HMG ) , patients with PCO , as compared with controls , had significantly higher serum oestradiol levels on the day of human chorionic gonadotrophin administration ( 5940 +/- 255 versus 4370 +/- 240 pmol/l , P < 0.001 ) , developed more follicles ( 14.9 +/- 0.7 versus 9.8 +/- 0.6 , P < 0.001 ) and produced more oocytes ( 9.3 +/- 0.6 versus 6.8 +/- 0.5 , P = 0.003 ) . However , fertilization rates were reduced in the PCO patients ( 52.8 +/- 3.4 % versus 66.1 +/- 3.4 % , P = 0.007 ) . There was no significant difference in cleavage rates . The pregnancy rate/embryo transfer was 25.4 % in the PCO group and 23.0 % in the group with normal ovaries . There were three high order multiple pregnancies in the PCO group compared with none in the group with normal ovaries . Of the PCO patients , 10.5 % developed moderate/severe ovarian hyperstimulation syndrome ( OHSS ) compared with none of the controls ( P = 0.006 ) . Patients with and without PCO undergoing IVF have comparable pregnancy and livebirth rates . However , it is important to diagnose PCO before ovarian stimulation is initiated as these patients are more likely to develop moderate or severe OHSS following IVF-ET .
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[ "Intervention_Physical", "Outcome_Physical", "Participant_Condition", "Participant_Sample-size" ]
Electromyography - Driven Neuromuscular Electrical Stimulation Robot is a Intervention_Physical, Stroke is a Participant_Condition, Augmented physical training with assistance from robot and neuromuscular electrical stimulation ( NMES ) is a Intervention_Educational, chronic stroke is a Participant_Condition, NMES robot - assisted wrist training is a Intervention_Educational, robot - assisted training . is a Intervention_Educational, Twenty - six is a Participant_Sample-size, hemiplegic is a Participant_Condition, 20-session wrist training with an electromyography ( EMG ) -driven NMES robot is a Intervention_Educational, EMG - driven robot is a Intervention_Physical, Fugl - Meyer Assessment ( FMA ) is a Outcome_Physical, Modified Ashworth Score ( MAS ) is a Outcome_Physical, Action Research Arm Test ( ARAT ) is a Outcome_Physical, improvement in FMA ( shoulder / elbow , wrist / hand ) is a Outcome_Physical, better performance is a Outcome_Other, releasing muscle co - contraction is a Outcome_Physical
69541_task0
Sentence: Wrist Rehabilitation Assisted by an Electromyography-Driven Neuromuscular Electrical Stimulation Robot After Stroke . BACKGROUND Augmented physical training with assistance from robot and neuromuscular electrical stimulation ( NMES ) may introduce intensive motor improvement in chronic stroke . OBJECTIVE To compare the rehabilitation effectiveness achieved by NMES robot-assisted wrist training and that by robot-assisted training . METHODS This study was a single-blinded randomized controlled trial with a 3-month follow-up . Twenty-six hemiplegic subjects with chronic stroke were randomly assigned to receive 20-session wrist training with an electromyography ( EMG ) -driven NMES robot ( NMES robot group , n = 11 ) and with an EMG-driven robot ( robot group , n = 15 ) , completed within 7 consecutive weeks . Clinical scores , Fugl-Meyer Assessment ( FMA ) , Modified Ashworth Score ( MAS ) , and Action Research Arm Test ( ARAT ) were used to evaluate the training effects before and after the training , as well as 3 months later . An EMG parameter , muscle co-contraction index , was also applied to investigate the session-by-session variation in muscular coordination patterns during the training . RESULTS The improvement in FMA ( shoulder/elbow , wrist/hand ) obtained in the NMES robot group was more significant than the robot group ( P < .05 ) . Significant improvement in ARAT was achieved in the NMES robot group ( P < .05 ) but absent in the robot group . NMES robot-assisted training showed better performance in releasing muscle co-contraction than the robot-assisted across the training sessions ( P < .05 ) . CONCLUSIONS The NMES robot-assisted wrist training was more effective than the pure robot . The additional NMES application in the treatment could bring more improvements in the distal motor functions and faster rehabilitation progress . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Physical, Participant_Condition, Intervention_Educational, Outcome_Physical, Participant_Sample-size, Outcome_Other
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Wrist Rehabilitation Assisted by an Electromyography-Driven Neuromuscular Electrical Stimulation Robot After Stroke . BACKGROUND Augmented physical training with assistance from robot and neuromuscular electrical stimulation ( NMES ) may introduce intensive motor improvement in chronic stroke . OBJECTIVE To compare the rehabilitation effectiveness achieved by NMES robot-assisted wrist training and that by robot-assisted training . METHODS This study was a single-blinded randomized controlled trial with a 3-month follow-up . Twenty-six hemiplegic subjects with chronic stroke were randomly assigned to receive 20-session wrist training with an electromyography ( EMG ) -driven NMES robot ( NMES robot group , n = 11 ) and with an EMG-driven robot ( robot group , n = 15 ) , completed within 7 consecutive weeks . Clinical scores , Fugl-Meyer Assessment ( FMA ) , Modified Ashworth Score ( MAS ) , and Action Research Arm Test ( ARAT ) were used to evaluate the training effects before and after the training , as well as 3 months later . An EMG parameter , muscle co-contraction index , was also applied to investigate the session-by-session variation in muscular coordination patterns during the training . RESULTS The improvement in FMA ( shoulder/elbow , wrist/hand ) obtained in the NMES robot group was more significant than the robot group ( P < .05 ) . Significant improvement in ARAT was achieved in the NMES robot group ( P < .05 ) but absent in the robot group . NMES robot-assisted training showed better performance in releasing muscle co-contraction than the robot-assisted across the training sessions ( P < .05 ) . CONCLUSIONS The NMES robot-assisted wrist training was more effective than the pure robot . The additional NMES application in the treatment could bring more improvements in the distal motor functions and faster rehabilitation progress .
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[ "Intervention_Educational", "Intervention_Physical", "Outcome_Physical", "Outcome_Other", "Participant_Condition", "Participant_Sample-size" ]
Electromyography - Driven Neuromuscular Electrical Stimulation Robot is a Intervention_Physical, Stroke is a Participant_Condition, Augmented physical training with assistance from robot and neuromuscular electrical stimulation ( NMES ) is a Intervention_Educational, chronic stroke is a Participant_Condition, NMES robot - assisted wrist training is a Intervention_Educational, robot - assisted training . is a Intervention_Educational, Twenty - six is a Participant_Sample-size, hemiplegic is a Participant_Condition, 20-session wrist training with an electromyography ( EMG ) -driven NMES robot is a Intervention_Educational, EMG - driven robot is a Intervention_Physical, Fugl - Meyer Assessment ( FMA ) is a Outcome_Physical, Modified Ashworth Score ( MAS ) is a Outcome_Physical, Action Research Arm Test ( ARAT ) is a Outcome_Physical, improvement in FMA ( shoulder / elbow , wrist / hand ) is a Outcome_Physical, better performance is a Outcome_Other, releasing muscle co - contraction is a Outcome_Physical
69541_task1
Sentence: Wrist Rehabilitation Assisted by an Electromyography-Driven Neuromuscular Electrical Stimulation Robot After Stroke . BACKGROUND Augmented physical training with assistance from robot and neuromuscular electrical stimulation ( NMES ) may introduce intensive motor improvement in chronic stroke . OBJECTIVE To compare the rehabilitation effectiveness achieved by NMES robot-assisted wrist training and that by robot-assisted training . METHODS This study was a single-blinded randomized controlled trial with a 3-month follow-up . Twenty-six hemiplegic subjects with chronic stroke were randomly assigned to receive 20-session wrist training with an electromyography ( EMG ) -driven NMES robot ( NMES robot group , n = 11 ) and with an EMG-driven robot ( robot group , n = 15 ) , completed within 7 consecutive weeks . Clinical scores , Fugl-Meyer Assessment ( FMA ) , Modified Ashworth Score ( MAS ) , and Action Research Arm Test ( ARAT ) were used to evaluate the training effects before and after the training , as well as 3 months later . An EMG parameter , muscle co-contraction index , was also applied to investigate the session-by-session variation in muscular coordination patterns during the training . RESULTS The improvement in FMA ( shoulder/elbow , wrist/hand ) obtained in the NMES robot group was more significant than the robot group ( P < .05 ) . Significant improvement in ARAT was achieved in the NMES robot group ( P < .05 ) but absent in the robot group . NMES robot-assisted training showed better performance in releasing muscle co-contraction than the robot-assisted across the training sessions ( P < .05 ) . CONCLUSIONS The NMES robot-assisted wrist training was more effective than the pure robot . The additional NMES application in the treatment could bring more improvements in the distal motor functions and faster rehabilitation progress . Instructions: please typing these entity words according to sentence: Electromyography - Driven Neuromuscular Electrical Stimulation Robot, Stroke, Augmented physical training with assistance from robot and neuromuscular electrical stimulation ( NMES ), chronic stroke, NMES robot - assisted wrist training, robot - assisted training ., Twenty - six, hemiplegic, 20-session wrist training with an electromyography ( EMG ) -driven NMES robot, EMG - driven robot, Fugl - Meyer Assessment ( FMA ), Modified Ashworth Score ( MAS ), Action Research Arm Test ( ARAT ), improvement in FMA ( shoulder / elbow , wrist / hand ), better performance, releasing muscle co - contraction Options: Intervention_Physical, Participant_Condition, Intervention_Educational, Outcome_Physical, Participant_Sample-size, Outcome_Other
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Wrist Rehabilitation Assisted by an Electromyography-Driven Neuromuscular Electrical Stimulation Robot After Stroke . BACKGROUND Augmented physical training with assistance from robot and neuromuscular electrical stimulation ( NMES ) may introduce intensive motor improvement in chronic stroke . OBJECTIVE To compare the rehabilitation effectiveness achieved by NMES robot-assisted wrist training and that by robot-assisted training . METHODS This study was a single-blinded randomized controlled trial with a 3-month follow-up . Twenty-six hemiplegic subjects with chronic stroke were randomly assigned to receive 20-session wrist training with an electromyography ( EMG ) -driven NMES robot ( NMES robot group , n = 11 ) and with an EMG-driven robot ( robot group , n = 15 ) , completed within 7 consecutive weeks . Clinical scores , Fugl-Meyer Assessment ( FMA ) , Modified Ashworth Score ( MAS ) , and Action Research Arm Test ( ARAT ) were used to evaluate the training effects before and after the training , as well as 3 months later . An EMG parameter , muscle co-contraction index , was also applied to investigate the session-by-session variation in muscular coordination patterns during the training . RESULTS The improvement in FMA ( shoulder/elbow , wrist/hand ) obtained in the NMES robot group was more significant than the robot group ( P < .05 ) . Significant improvement in ARAT was achieved in the NMES robot group ( P < .05 ) but absent in the robot group . NMES robot-assisted training showed better performance in releasing muscle co-contraction than the robot-assisted across the training sessions ( P < .05 ) . CONCLUSIONS The NMES robot-assisted wrist training was more effective than the pure robot . The additional NMES application in the treatment could bring more improvements in the distal motor functions and faster rehabilitation progress .
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[ "Intervention_Educational", "Intervention_Physical", "Outcome_Physical", "Outcome_Other", "Participant_Condition", "Participant_Sample-size" ]
Electromyography - Driven Neuromuscular Electrical Stimulation Robot, Stroke, Augmented physical training with assistance from robot and neuromuscular electrical stimulation ( NMES ), chronic stroke, NMES robot - assisted wrist training, robot - assisted training ., Twenty - six, hemiplegic, 20-session wrist training with an electromyography ( EMG ) -driven NMES robot, EMG - driven robot, Fugl - Meyer Assessment ( FMA ), Modified Ashworth Score ( MAS ), Action Research Arm Test ( ARAT ), improvement in FMA ( shoulder / elbow , wrist / hand ), better performance, releasing muscle co - contraction
69541_task2
Sentence: Wrist Rehabilitation Assisted by an Electromyography-Driven Neuromuscular Electrical Stimulation Robot After Stroke . BACKGROUND Augmented physical training with assistance from robot and neuromuscular electrical stimulation ( NMES ) may introduce intensive motor improvement in chronic stroke . OBJECTIVE To compare the rehabilitation effectiveness achieved by NMES robot-assisted wrist training and that by robot-assisted training . METHODS This study was a single-blinded randomized controlled trial with a 3-month follow-up . Twenty-six hemiplegic subjects with chronic stroke were randomly assigned to receive 20-session wrist training with an electromyography ( EMG ) -driven NMES robot ( NMES robot group , n = 11 ) and with an EMG-driven robot ( robot group , n = 15 ) , completed within 7 consecutive weeks . Clinical scores , Fugl-Meyer Assessment ( FMA ) , Modified Ashworth Score ( MAS ) , and Action Research Arm Test ( ARAT ) were used to evaluate the training effects before and after the training , as well as 3 months later . An EMG parameter , muscle co-contraction index , was also applied to investigate the session-by-session variation in muscular coordination patterns during the training . RESULTS The improvement in FMA ( shoulder/elbow , wrist/hand ) obtained in the NMES robot group was more significant than the robot group ( P < .05 ) . Significant improvement in ARAT was achieved in the NMES robot group ( P < .05 ) but absent in the robot group . NMES robot-assisted training showed better performance in releasing muscle co-contraction than the robot-assisted across the training sessions ( P < .05 ) . CONCLUSIONS The NMES robot-assisted wrist training was more effective than the pure robot . The additional NMES application in the treatment could bring more improvements in the distal motor functions and faster rehabilitation progress . Instructions: please extract entity words from the input sentence
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Wrist Rehabilitation Assisted by an Electromyography-Driven Neuromuscular Electrical Stimulation Robot After Stroke . BACKGROUND Augmented physical training with assistance from robot and neuromuscular electrical stimulation ( NMES ) may introduce intensive motor improvement in chronic stroke . OBJECTIVE To compare the rehabilitation effectiveness achieved by NMES robot-assisted wrist training and that by robot-assisted training . METHODS This study was a single-blinded randomized controlled trial with a 3-month follow-up . Twenty-six hemiplegic subjects with chronic stroke were randomly assigned to receive 20-session wrist training with an electromyography ( EMG ) -driven NMES robot ( NMES robot group , n = 11 ) and with an EMG-driven robot ( robot group , n = 15 ) , completed within 7 consecutive weeks . Clinical scores , Fugl-Meyer Assessment ( FMA ) , Modified Ashworth Score ( MAS ) , and Action Research Arm Test ( ARAT ) were used to evaluate the training effects before and after the training , as well as 3 months later . An EMG parameter , muscle co-contraction index , was also applied to investigate the session-by-session variation in muscular coordination patterns during the training . RESULTS The improvement in FMA ( shoulder/elbow , wrist/hand ) obtained in the NMES robot group was more significant than the robot group ( P < .05 ) . Significant improvement in ARAT was achieved in the NMES robot group ( P < .05 ) but absent in the robot group . NMES robot-assisted training showed better performance in releasing muscle co-contraction than the robot-assisted across the training sessions ( P < .05 ) . CONCLUSIONS The NMES robot-assisted wrist training was more effective than the pure robot . The additional NMES application in the treatment could bring more improvements in the distal motor functions and faster rehabilitation progress .
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[ "Intervention_Educational", "Intervention_Physical", "Outcome_Physical", "Outcome_Other", "Participant_Condition", "Participant_Sample-size" ]
beta - subunit is a Protein, alpha is a Protein, beta subunits is a Protein, beta subunit is a Protein, asparagine is a Entity, tryptophan is a Entity, lutropin - beta is a Protein
316_task0
Sentence: Human pituitary lutropin. Isolation, properties, and the complete amino acid sequence of the beta-subunit. The separation of alpha and beta subunits from human pituitary lutropin is described, and the complete amino acid sequence of the beta subunit is proposed. It consists of 115 amino acids with serine and glycine at the amino and carboxyl termini, respectively. The single carbohydrate moiety is linked to asparagine in position 30 and the single tryptophan of the lutropin molecule is located at position 8. The two methionine residues in lutropin-beta are in positions 41 and 42. In addition to COOH-terminal heterogeneity, evidence for internal peptide cleavages was observed. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Entity, Protein
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Human pituitary lutropin. Isolation, properties, and the complete amino acid sequence of the beta-subunit. The separation of alpha and beta subunits from human pituitary lutropin is described, and the complete amino acid sequence of the beta subunit is proposed. It consists of 115 amino acids with serine and glycine at the amino and carboxyl termini, respectively. The single carbohydrate moiety is linked to asparagine in position 30 and the single tryptophan of the lutropin molecule is located at position 8. The two methionine residues in lutropin-beta are in positions 41 and 42. In addition to COOH-terminal heterogeneity, evidence for internal peptide cleavages was observed.
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[ "Protein", "Entity" ]
beta - subunit is a Protein, alpha is a Protein, beta subunits is a Protein, beta subunit is a Protein, asparagine is a Entity, tryptophan is a Entity, lutropin - beta is a Protein
316_task1
Sentence: Human pituitary lutropin. Isolation, properties, and the complete amino acid sequence of the beta-subunit. The separation of alpha and beta subunits from human pituitary lutropin is described, and the complete amino acid sequence of the beta subunit is proposed. It consists of 115 amino acids with serine and glycine at the amino and carboxyl termini, respectively. The single carbohydrate moiety is linked to asparagine in position 30 and the single tryptophan of the lutropin molecule is located at position 8. The two methionine residues in lutropin-beta are in positions 41 and 42. In addition to COOH-terminal heterogeneity, evidence for internal peptide cleavages was observed. Instructions: please typing these entity words according to sentence: beta - subunit, alpha, beta subunits, beta subunit, asparagine, tryptophan, lutropin - beta Options: Entity, Protein
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Human pituitary lutropin. Isolation, properties, and the complete amino acid sequence of the beta-subunit. The separation of alpha and beta subunits from human pituitary lutropin is described, and the complete amino acid sequence of the beta subunit is proposed. It consists of 115 amino acids with serine and glycine at the amino and carboxyl termini, respectively. The single carbohydrate moiety is linked to asparagine in position 30 and the single tryptophan of the lutropin molecule is located at position 8. The two methionine residues in lutropin-beta are in positions 41 and 42. In addition to COOH-terminal heterogeneity, evidence for internal peptide cleavages was observed.
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[ "Protein", "Entity" ]
beta - subunit, alpha, beta subunits, beta subunit, asparagine, tryptophan, lutropin - beta
316_task2
Sentence: Human pituitary lutropin. Isolation, properties, and the complete amino acid sequence of the beta-subunit. The separation of alpha and beta subunits from human pituitary lutropin is described, and the complete amino acid sequence of the beta subunit is proposed. It consists of 115 amino acids with serine and glycine at the amino and carboxyl termini, respectively. The single carbohydrate moiety is linked to asparagine in position 30 and the single tryptophan of the lutropin molecule is located at position 8. The two methionine residues in lutropin-beta are in positions 41 and 42. In addition to COOH-terminal heterogeneity, evidence for internal peptide cleavages was observed. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Human pituitary lutropin. Isolation, properties, and the complete amino acid sequence of the beta-subunit. The separation of alpha and beta subunits from human pituitary lutropin is described, and the complete amino acid sequence of the beta subunit is proposed. It consists of 115 amino acids with serine and glycine at the amino and carboxyl termini, respectively. The single carbohydrate moiety is linked to asparagine in position 30 and the single tryptophan of the lutropin molecule is located at position 8. The two methionine residues in lutropin-beta are in positions 41 and 42. In addition to COOH-terminal heterogeneity, evidence for internal peptide cleavages was observed.
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[ "Protein", "Entity" ]
measurements is an umlsterm, X - ray is an umlsterm, calcification is an umlsterm, vertebral fractures is an umlsterm, diseases is an umlsterm, bone density is an umlsterm, measurements is an umlsterm, spine is an umlsterm, femur is an umlsterm, Measurements is an umlsterm, lat is an umlsterm, Ward 's is an umlsterm, patients is an umlsterm, measurements is an umlsterm, diseases is an umlsterm, patients is an umlsterm, diagnosis is an umlsterm, osteoarthrosis is an umlsterm, osteoporosis is an umlsterm, rheumatoid arthritis is an umlsterm, control group is an umlsterm, variation is an umlsterm, measure is an umlsterm, measurements is an umlsterm, variation is an umlsterm, value is an umlsterm, lat is an umlsterm, Ward 's is an umlsterm, variation is an umlsterm, osteoporosis is an umlsterm, patients is an umlsterm, control group is an umlsterm, measurements is an umlsterm, measurements is an umlsterm, measurements is an umlsterm, Ward 's is an umlsterm, documentation is an umlsterm, bone density is an umlsterm
ZfuerRheumatologie.90580283.eng.abstr_task0
Sentence: Precision of osteodensitometric measurements using dual energy X-ray absorptiometry ( DEXA ) depends on various known factors , such as positioning , aortic calcification or vertebral fractures . The purpose of this study was to investigate the influence of various diseases or bone density on the reproducibility of measurements in the lumbar spine and the proximal femur . Measurements in the LWS p.a. , LWS lat . and at Ward's triangle were made in a total of 100 patients . The subjects were repositioned between measurements . In order to be able to determine the influence of various diseases , four groups of 25 patients each were formed : three with the diagnosis osteoarthrosis , osteoporosis and rheumatoid arthritis and one control group . The mean percentual difference and coefficient of variation were calculated as the measure for reproducibility . Mean percentual differences of 0.18 to 2.6% were found in the four groups at the three measurements sites . After calculation of coefficient of variation , a value between 1.2 and 2.7% was found for LWS p.a. , between 7.1 and 15.7% for LWS lat . and between 4.1 and 9.9% at Ward's triangle . It was also conspicuous that the difference in coefficient of variation in osteoporosis patients was nearly double that in the control group in all measured areas . Conclusion : Lateral lumbar spinal measurements using DEXA cannot presently be recommended . LWS p.a. measurements and , with limitations , measurements at Ward's triangle have good precision and could be used for course documentation of bone density . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Precision of osteodensitometric measurements using dual energy X-ray absorptiometry ( DEXA ) depends on various known factors , such as positioning , aortic calcification or vertebral fractures . The purpose of this study was to investigate the influence of various diseases or bone density on the reproducibility of measurements in the lumbar spine and the proximal femur . Measurements in the LWS p.a. , LWS lat . and at Ward's triangle were made in a total of 100 patients . The subjects were repositioned between measurements . In order to be able to determine the influence of various diseases , four groups of 25 patients each were formed : three with the diagnosis osteoarthrosis , osteoporosis and rheumatoid arthritis and one control group . The mean percentual difference and coefficient of variation were calculated as the measure for reproducibility . Mean percentual differences of 0.18 to 2.6% were found in the four groups at the three measurements sites . After calculation of coefficient of variation , a value between 1.2 and 2.7% was found for LWS p.a. , between 7.1 and 15.7% for LWS lat . and between 4.1 and 9.9% at Ward's triangle . It was also conspicuous that the difference in coefficient of variation in osteoporosis patients was nearly double that in the control group in all measured areas . Conclusion : Lateral lumbar spinal measurements using DEXA cannot presently be recommended . LWS p.a. measurements and , with limitations , measurements at Ward's triangle have good precision and could be used for course documentation of bone density .
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[ "umlsterm" ]
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ZfuerRheumatologie.90580283.eng.abstr_task1
Sentence: Precision of osteodensitometric measurements using dual energy X-ray absorptiometry ( DEXA ) depends on various known factors , such as positioning , aortic calcification or vertebral fractures . The purpose of this study was to investigate the influence of various diseases or bone density on the reproducibility of measurements in the lumbar spine and the proximal femur . Measurements in the LWS p.a. , LWS lat . and at Ward's triangle were made in a total of 100 patients . The subjects were repositioned between measurements . In order to be able to determine the influence of various diseases , four groups of 25 patients each were formed : three with the diagnosis osteoarthrosis , osteoporosis and rheumatoid arthritis and one control group . The mean percentual difference and coefficient of variation were calculated as the measure for reproducibility . Mean percentual differences of 0.18 to 2.6% were found in the four groups at the three measurements sites . After calculation of coefficient of variation , a value between 1.2 and 2.7% was found for LWS p.a. , between 7.1 and 15.7% for LWS lat . and between 4.1 and 9.9% at Ward's triangle . It was also conspicuous that the difference in coefficient of variation in osteoporosis patients was nearly double that in the control group in all measured areas . Conclusion : Lateral lumbar spinal measurements using DEXA cannot presently be recommended . LWS p.a. measurements and , with limitations , measurements at Ward's triangle have good precision and could be used for course documentation of bone density . Instructions: please typing these entity words according to sentence: measurements, X - ray, calcification, vertebral fractures, diseases, bone density, measurements, spine, femur, Measurements, lat, Ward 's, patients, measurements, diseases, patients, diagnosis, osteoarthrosis, osteoporosis, rheumatoid arthritis, control group, variation, measure, measurements, variation, value, lat, Ward 's, variation, osteoporosis, patients, control group, measurements, measurements, measurements, Ward 's, documentation, bone density Options: umlsterm
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Precision of osteodensitometric measurements using dual energy X-ray absorptiometry ( DEXA ) depends on various known factors , such as positioning , aortic calcification or vertebral fractures . The purpose of this study was to investigate the influence of various diseases or bone density on the reproducibility of measurements in the lumbar spine and the proximal femur . Measurements in the LWS p.a. , LWS lat . and at Ward's triangle were made in a total of 100 patients . The subjects were repositioned between measurements . In order to be able to determine the influence of various diseases , four groups of 25 patients each were formed : three with the diagnosis osteoarthrosis , osteoporosis and rheumatoid arthritis and one control group . The mean percentual difference and coefficient of variation were calculated as the measure for reproducibility . Mean percentual differences of 0.18 to 2.6% were found in the four groups at the three measurements sites . After calculation of coefficient of variation , a value between 1.2 and 2.7% was found for LWS p.a. , between 7.1 and 15.7% for LWS lat . and between 4.1 and 9.9% at Ward's triangle . It was also conspicuous that the difference in coefficient of variation in osteoporosis patients was nearly double that in the control group in all measured areas . Conclusion : Lateral lumbar spinal measurements using DEXA cannot presently be recommended . LWS p.a. measurements and , with limitations , measurements at Ward's triangle have good precision and could be used for course documentation of bone density .
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[ "umlsterm" ]
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ZfuerRheumatologie.90580283.eng.abstr_task2
Sentence: Precision of osteodensitometric measurements using dual energy X-ray absorptiometry ( DEXA ) depends on various known factors , such as positioning , aortic calcification or vertebral fractures . The purpose of this study was to investigate the influence of various diseases or bone density on the reproducibility of measurements in the lumbar spine and the proximal femur . Measurements in the LWS p.a. , LWS lat . and at Ward's triangle were made in a total of 100 patients . The subjects were repositioned between measurements . In order to be able to determine the influence of various diseases , four groups of 25 patients each were formed : three with the diagnosis osteoarthrosis , osteoporosis and rheumatoid arthritis and one control group . The mean percentual difference and coefficient of variation were calculated as the measure for reproducibility . Mean percentual differences of 0.18 to 2.6% were found in the four groups at the three measurements sites . After calculation of coefficient of variation , a value between 1.2 and 2.7% was found for LWS p.a. , between 7.1 and 15.7% for LWS lat . and between 4.1 and 9.9% at Ward's triangle . It was also conspicuous that the difference in coefficient of variation in osteoporosis patients was nearly double that in the control group in all measured areas . Conclusion : Lateral lumbar spinal measurements using DEXA cannot presently be recommended . LWS p.a. measurements and , with limitations , measurements at Ward's triangle have good precision and could be used for course documentation of bone density . Instructions: please extract entity words from the input sentence
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Precision of osteodensitometric measurements using dual energy X-ray absorptiometry ( DEXA ) depends on various known factors , such as positioning , aortic calcification or vertebral fractures . The purpose of this study was to investigate the influence of various diseases or bone density on the reproducibility of measurements in the lumbar spine and the proximal femur . Measurements in the LWS p.a. , LWS lat . and at Ward's triangle were made in a total of 100 patients . The subjects were repositioned between measurements . In order to be able to determine the influence of various diseases , four groups of 25 patients each were formed : three with the diagnosis osteoarthrosis , osteoporosis and rheumatoid arthritis and one control group . The mean percentual difference and coefficient of variation were calculated as the measure for reproducibility . Mean percentual differences of 0.18 to 2.6% were found in the four groups at the three measurements sites . After calculation of coefficient of variation , a value between 1.2 and 2.7% was found for LWS p.a. , between 7.1 and 15.7% for LWS lat . and between 4.1 and 9.9% at Ward's triangle . It was also conspicuous that the difference in coefficient of variation in osteoporosis patients was nearly double that in the control group in all measured areas . Conclusion : Lateral lumbar spinal measurements using DEXA cannot presently be recommended . LWS p.a. measurements and , with limitations , measurements at Ward's triangle have good precision and could be used for course documentation of bone density .
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[ "umlsterm" ]
long - term exogenous subclinical hyperthyroid is a Intervention_Physical, cardiovascular morbidity . is a Outcome_Physical, myocardial is a Outcome_Physical, exogenous subclinical hyperthyroidism is a Intervention_Physical, two - dimensional speckle tracking echocardiography imaging ( 2D - STE ) is a Intervention_Physical, TSH - suppressive l - T ( 4 ) substitution is a Intervention_Pharmacological, restoration of euthyroidism is a Intervention_Pharmacological, normal left ventricular ( LV ) systolic function is a Outcome_Physical, impaired diastolic function is a Outcome_Physical, subclinical LV systolic and diastolic dysfunction is a Outcome_Physical, impaired circumferential and longitudinal strain and strain rate is a Outcome_Physical, improvement in LV systolic and diastolic function is a Outcome_Physical, Prolonged subclinical hyperthyroidism is a Intervention_Physical
46389_task0
Sentence: Abnormal cardiac contractility in long-term exogenous subclinical hyperthyroid patients as demonstrated by two-dimensional echocardiography speckle tracking imaging . BACKGROUND Subclinical hyperthyroidism is associated with cardiovascular morbidity . Recent advances in echocardiography imaging have allowed sophisticated evaluation of myocardial tissue properties . OBJECTIVE To investigate the myocardial effects of long-term exogenous subclinical hyperthyroidism using two-dimensional speckle tracking echocardiography imaging ( 2D-STE ) . DESIGN Prospective , single-blinded , placebo-controlled randomized trial of 6 months duration with two parallel groups . PATIENTS AND METHODS Totally 25 patients with a history of differentiated thyroid carcinoma on long-term TSH-suppressive levothyroxine ( l-T ( 4 ) ) substitution were randomized to persistent TSH-suppressive l-T ( 4 ) substitution ( low-TSH group ) or restoration of euthyroidism . Additionally 40 euthyroid controls were studied . RESULTS ( PROPOSAL ) : At baseline , the group of patients showed normal left ventricular ( LV ) systolic function but impaired diastolic function as assessed with conventional echocardiographic parameters . Importantly , 2D-STE analysis demonstrated the presence of subclinical LV systolic and diastolic dysfunction with impaired circumferential and longitudinal strain and strain rate at the isovolumic relaxation time . After restoration of euthyroidism , a significant improvement in LV systolic and diastolic function as assessed with 2D-STE strain was observed . CONCLUSION Prolonged subclinical hyperthyroidism leads to systolic and diastolic dysfunction , which is reversible after restoration of euthyroidism . 2D-STE is a more sensitive technique to evaluate subtle changes in LV performance of these patients . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Physical, Intervention_Pharmacological, Outcome_Physical
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Abnormal cardiac contractility in long-term exogenous subclinical hyperthyroid patients as demonstrated by two-dimensional echocardiography speckle tracking imaging . BACKGROUND Subclinical hyperthyroidism is associated with cardiovascular morbidity . Recent advances in echocardiography imaging have allowed sophisticated evaluation of myocardial tissue properties . OBJECTIVE To investigate the myocardial effects of long-term exogenous subclinical hyperthyroidism using two-dimensional speckle tracking echocardiography imaging ( 2D-STE ) . DESIGN Prospective , single-blinded , placebo-controlled randomized trial of 6 months duration with two parallel groups . PATIENTS AND METHODS Totally 25 patients with a history of differentiated thyroid carcinoma on long-term TSH-suppressive levothyroxine ( l-T ( 4 ) ) substitution were randomized to persistent TSH-suppressive l-T ( 4 ) substitution ( low-TSH group ) or restoration of euthyroidism . Additionally 40 euthyroid controls were studied . RESULTS ( PROPOSAL ) : At baseline , the group of patients showed normal left ventricular ( LV ) systolic function but impaired diastolic function as assessed with conventional echocardiographic parameters . Importantly , 2D-STE analysis demonstrated the presence of subclinical LV systolic and diastolic dysfunction with impaired circumferential and longitudinal strain and strain rate at the isovolumic relaxation time . After restoration of euthyroidism , a significant improvement in LV systolic and diastolic function as assessed with 2D-STE strain was observed . CONCLUSION Prolonged subclinical hyperthyroidism leads to systolic and diastolic dysfunction , which is reversible after restoration of euthyroidism . 2D-STE is a more sensitive technique to evaluate subtle changes in LV performance of these patients .
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[ "Intervention_Physical", "Outcome_Physical", "Intervention_Pharmacological", "Participant_Condition" ]
long - term exogenous subclinical hyperthyroid is a Intervention_Physical, cardiovascular morbidity . is a Outcome_Physical, myocardial is a Outcome_Physical, exogenous subclinical hyperthyroidism is a Intervention_Physical, two - dimensional speckle tracking echocardiography imaging ( 2D - STE ) is a Intervention_Physical, TSH - suppressive l - T ( 4 ) substitution is a Intervention_Pharmacological, restoration of euthyroidism is a Intervention_Pharmacological, normal left ventricular ( LV ) systolic function is a Outcome_Physical, impaired diastolic function is a Outcome_Physical, subclinical LV systolic and diastolic dysfunction is a Outcome_Physical, impaired circumferential and longitudinal strain and strain rate is a Outcome_Physical, improvement in LV systolic and diastolic function is a Outcome_Physical, Prolonged subclinical hyperthyroidism is a Intervention_Physical
46389_task1
Sentence: Abnormal cardiac contractility in long-term exogenous subclinical hyperthyroid patients as demonstrated by two-dimensional echocardiography speckle tracking imaging . BACKGROUND Subclinical hyperthyroidism is associated with cardiovascular morbidity . Recent advances in echocardiography imaging have allowed sophisticated evaluation of myocardial tissue properties . OBJECTIVE To investigate the myocardial effects of long-term exogenous subclinical hyperthyroidism using two-dimensional speckle tracking echocardiography imaging ( 2D-STE ) . DESIGN Prospective , single-blinded , placebo-controlled randomized trial of 6 months duration with two parallel groups . PATIENTS AND METHODS Totally 25 patients with a history of differentiated thyroid carcinoma on long-term TSH-suppressive levothyroxine ( l-T ( 4 ) ) substitution were randomized to persistent TSH-suppressive l-T ( 4 ) substitution ( low-TSH group ) or restoration of euthyroidism . Additionally 40 euthyroid controls were studied . RESULTS ( PROPOSAL ) : At baseline , the group of patients showed normal left ventricular ( LV ) systolic function but impaired diastolic function as assessed with conventional echocardiographic parameters . Importantly , 2D-STE analysis demonstrated the presence of subclinical LV systolic and diastolic dysfunction with impaired circumferential and longitudinal strain and strain rate at the isovolumic relaxation time . After restoration of euthyroidism , a significant improvement in LV systolic and diastolic function as assessed with 2D-STE strain was observed . CONCLUSION Prolonged subclinical hyperthyroidism leads to systolic and diastolic dysfunction , which is reversible after restoration of euthyroidism . 2D-STE is a more sensitive technique to evaluate subtle changes in LV performance of these patients . Instructions: please typing these entity words according to sentence: long - term exogenous subclinical hyperthyroid, cardiovascular morbidity ., myocardial, exogenous subclinical hyperthyroidism, two - dimensional speckle tracking echocardiography imaging ( 2D - STE ), TSH - suppressive l - T ( 4 ) substitution, restoration of euthyroidism, normal left ventricular ( LV ) systolic function, impaired diastolic function, subclinical LV systolic and diastolic dysfunction, impaired circumferential and longitudinal strain and strain rate, improvement in LV systolic and diastolic function, Prolonged subclinical hyperthyroidism Options: Intervention_Physical, Intervention_Pharmacological, Outcome_Physical
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Abnormal cardiac contractility in long-term exogenous subclinical hyperthyroid patients as demonstrated by two-dimensional echocardiography speckle tracking imaging . BACKGROUND Subclinical hyperthyroidism is associated with cardiovascular morbidity . Recent advances in echocardiography imaging have allowed sophisticated evaluation of myocardial tissue properties . OBJECTIVE To investigate the myocardial effects of long-term exogenous subclinical hyperthyroidism using two-dimensional speckle tracking echocardiography imaging ( 2D-STE ) . DESIGN Prospective , single-blinded , placebo-controlled randomized trial of 6 months duration with two parallel groups . PATIENTS AND METHODS Totally 25 patients with a history of differentiated thyroid carcinoma on long-term TSH-suppressive levothyroxine ( l-T ( 4 ) ) substitution were randomized to persistent TSH-suppressive l-T ( 4 ) substitution ( low-TSH group ) or restoration of euthyroidism . Additionally 40 euthyroid controls were studied . RESULTS ( PROPOSAL ) : At baseline , the group of patients showed normal left ventricular ( LV ) systolic function but impaired diastolic function as assessed with conventional echocardiographic parameters . Importantly , 2D-STE analysis demonstrated the presence of subclinical LV systolic and diastolic dysfunction with impaired circumferential and longitudinal strain and strain rate at the isovolumic relaxation time . After restoration of euthyroidism , a significant improvement in LV systolic and diastolic function as assessed with 2D-STE strain was observed . CONCLUSION Prolonged subclinical hyperthyroidism leads to systolic and diastolic dysfunction , which is reversible after restoration of euthyroidism . 2D-STE is a more sensitive technique to evaluate subtle changes in LV performance of these patients .
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[ "Intervention_Physical", "Outcome_Physical", "Intervention_Pharmacological", "Participant_Condition" ]
long - term exogenous subclinical hyperthyroid, cardiovascular morbidity ., myocardial, exogenous subclinical hyperthyroidism, two - dimensional speckle tracking echocardiography imaging ( 2D - STE ), TSH - suppressive l - T ( 4 ) substitution, restoration of euthyroidism, normal left ventricular ( LV ) systolic function, impaired diastolic function, subclinical LV systolic and diastolic dysfunction, impaired circumferential and longitudinal strain and strain rate, improvement in LV systolic and diastolic function, Prolonged subclinical hyperthyroidism
46389_task2
Sentence: Abnormal cardiac contractility in long-term exogenous subclinical hyperthyroid patients as demonstrated by two-dimensional echocardiography speckle tracking imaging . BACKGROUND Subclinical hyperthyroidism is associated with cardiovascular morbidity . Recent advances in echocardiography imaging have allowed sophisticated evaluation of myocardial tissue properties . OBJECTIVE To investigate the myocardial effects of long-term exogenous subclinical hyperthyroidism using two-dimensional speckle tracking echocardiography imaging ( 2D-STE ) . DESIGN Prospective , single-blinded , placebo-controlled randomized trial of 6 months duration with two parallel groups . PATIENTS AND METHODS Totally 25 patients with a history of differentiated thyroid carcinoma on long-term TSH-suppressive levothyroxine ( l-T ( 4 ) ) substitution were randomized to persistent TSH-suppressive l-T ( 4 ) substitution ( low-TSH group ) or restoration of euthyroidism . Additionally 40 euthyroid controls were studied . RESULTS ( PROPOSAL ) : At baseline , the group of patients showed normal left ventricular ( LV ) systolic function but impaired diastolic function as assessed with conventional echocardiographic parameters . Importantly , 2D-STE analysis demonstrated the presence of subclinical LV systolic and diastolic dysfunction with impaired circumferential and longitudinal strain and strain rate at the isovolumic relaxation time . After restoration of euthyroidism , a significant improvement in LV systolic and diastolic function as assessed with 2D-STE strain was observed . CONCLUSION Prolonged subclinical hyperthyroidism leads to systolic and diastolic dysfunction , which is reversible after restoration of euthyroidism . 2D-STE is a more sensitive technique to evaluate subtle changes in LV performance of these patients . Instructions: please extract entity words from the input sentence
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Abnormal cardiac contractility in long-term exogenous subclinical hyperthyroid patients as demonstrated by two-dimensional echocardiography speckle tracking imaging . BACKGROUND Subclinical hyperthyroidism is associated with cardiovascular morbidity . Recent advances in echocardiography imaging have allowed sophisticated evaluation of myocardial tissue properties . OBJECTIVE To investigate the myocardial effects of long-term exogenous subclinical hyperthyroidism using two-dimensional speckle tracking echocardiography imaging ( 2D-STE ) . DESIGN Prospective , single-blinded , placebo-controlled randomized trial of 6 months duration with two parallel groups . PATIENTS AND METHODS Totally 25 patients with a history of differentiated thyroid carcinoma on long-term TSH-suppressive levothyroxine ( l-T ( 4 ) ) substitution were randomized to persistent TSH-suppressive l-T ( 4 ) substitution ( low-TSH group ) or restoration of euthyroidism . Additionally 40 euthyroid controls were studied . RESULTS ( PROPOSAL ) : At baseline , the group of patients showed normal left ventricular ( LV ) systolic function but impaired diastolic function as assessed with conventional echocardiographic parameters . Importantly , 2D-STE analysis demonstrated the presence of subclinical LV systolic and diastolic dysfunction with impaired circumferential and longitudinal strain and strain rate at the isovolumic relaxation time . After restoration of euthyroidism , a significant improvement in LV systolic and diastolic function as assessed with 2D-STE strain was observed . CONCLUSION Prolonged subclinical hyperthyroidism leads to systolic and diastolic dysfunction , which is reversible after restoration of euthyroidism . 2D-STE is a more sensitive technique to evaluate subtle changes in LV performance of these patients .
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[ "Intervention_Physical", "Outcome_Physical", "Intervention_Pharmacological", "Participant_Condition" ]
DGAT1 is a protein, leptin is a protein, growth hormone is a protein, beta - hydroxybutyrate is a compound, glucose is a compound
DS.d1363_task0
Sentence: The objective of this study was to examine the impact of polymorphisms in the acyl-CoA:diacylglycerol acyltransferase (DGAT1), leptin and growth hormone receptor genes on body energy (body condition score, total body energy content and cumulative effective energy balance) and blood metabolic traits (levels of beta-hydroxybutyrate, glucose and non-esterified fatty acids), measured once before the first calving and then repeatedly throughout first lactation in 497 Holstein cows. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein
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The objective of this study was to examine the impact of polymorphisms in the acyl-CoA:diacylglycerol acyltransferase (DGAT1), leptin and growth hormone receptor genes on body energy (body condition score, total body energy content and cumulative effective energy balance) and blood metabolic traits (levels of beta-hydroxybutyrate, glucose and non-esterified fatty acids), measured once before the first calving and then repeatedly throughout first lactation in 497 Holstein cows.
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[ "compound", "protein" ]
DGAT1 is a protein, leptin is a protein, growth hormone is a protein, beta - hydroxybutyrate is a compound, glucose is a compound
DS.d1363_task1
Sentence: The objective of this study was to examine the impact of polymorphisms in the acyl-CoA:diacylglycerol acyltransferase (DGAT1), leptin and growth hormone receptor genes on body energy (body condition score, total body energy content and cumulative effective energy balance) and blood metabolic traits (levels of beta-hydroxybutyrate, glucose and non-esterified fatty acids), measured once before the first calving and then repeatedly throughout first lactation in 497 Holstein cows. Instructions: please typing these entity words according to sentence: DGAT1, leptin, growth hormone, beta - hydroxybutyrate, glucose Options: compound, protein
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The objective of this study was to examine the impact of polymorphisms in the acyl-CoA:diacylglycerol acyltransferase (DGAT1), leptin and growth hormone receptor genes on body energy (body condition score, total body energy content and cumulative effective energy balance) and blood metabolic traits (levels of beta-hydroxybutyrate, glucose and non-esterified fatty acids), measured once before the first calving and then repeatedly throughout first lactation in 497 Holstein cows.
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[ "compound", "protein" ]
DGAT1, leptin, growth hormone, beta - hydroxybutyrate, glucose
DS.d1363_task2
Sentence: The objective of this study was to examine the impact of polymorphisms in the acyl-CoA:diacylglycerol acyltransferase (DGAT1), leptin and growth hormone receptor genes on body energy (body condition score, total body energy content and cumulative effective energy balance) and blood metabolic traits (levels of beta-hydroxybutyrate, glucose and non-esterified fatty acids), measured once before the first calving and then repeatedly throughout first lactation in 497 Holstein cows. Instructions: please extract entity words from the input sentence
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The objective of this study was to examine the impact of polymorphisms in the acyl-CoA:diacylglycerol acyltransferase (DGAT1), leptin and growth hormone receptor genes on body energy (body condition score, total body energy content and cumulative effective energy balance) and blood metabolic traits (levels of beta-hydroxybutyrate, glucose and non-esterified fatty acids), measured once before the first calving and then repeatedly throughout first lactation in 497 Holstein cows.
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[ "compound", "protein" ]
Ueberdruckbeatmung is an umlsterm, unerwuenschten Nebenwirkungen is an umlsterm, Patient is an umlsterm, Atemarbeit is an umlsterm, Technik is an umlsterm, Atemarbeit is an umlsterm
IntensiveMedizin.90360220.ger.abstr_task0
Sentence: Kontrollierte mechanische Ueberdruckbeatmung hat eine Reihe von unerwuenschten Nebenwirkungen , die durch den Einsatz unterstuetzender Spontanatmungsverfahren teilweise vermieden werden koennen . Deshalb werden heute assistierende Verfahren zur Beatmung eingesetzt , und zwar nicht nur in der Phase der Entwoehnung von der Beatmung , sondern bereits im akuten Krankheitsverlauf . Ziel assistierender Beatmungsformen ist es moeglichst eine optimale Synchronisation zwischen Patient und Maschine und eine Reduzierung der Atemarbeit zu erreichen . Zur Optimierung der bekannten Verfahren wird einerseits eine Technik beschrieben , die den durch den Tubus bedingt erhoehten Atemwiderstand ausgleicht bzw. kompensiert ( automatische Tubuskompensation ( ATC ) ) . Darueber hinaus stellt die proportional assistierende Beatmung ( PAV ) eine Beatmungsform dar , bei der nicht nur der Atemwiderstand durch die Beatmungsmaschine in variablem Ausmass kompensiert wird , sondern auch elastische Widerstandkomponenten der Atemarbeit kompensiert werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]
Kontrollierte mechanische Ueberdruckbeatmung hat eine Reihe von unerwuenschten Nebenwirkungen , die durch den Einsatz unterstuetzender Spontanatmungsverfahren teilweise vermieden werden koennen . Deshalb werden heute assistierende Verfahren zur Beatmung eingesetzt , und zwar nicht nur in der Phase der Entwoehnung von der Beatmung , sondern bereits im akuten Krankheitsverlauf . Ziel assistierender Beatmungsformen ist es moeglichst eine optimale Synchronisation zwischen Patient und Maschine und eine Reduzierung der Atemarbeit zu erreichen . Zur Optimierung der bekannten Verfahren wird einerseits eine Technik beschrieben , die den durch den Tubus bedingt erhoehten Atemwiderstand ausgleicht bzw. kompensiert ( automatische Tubuskompensation ( ATC ) ) . Darueber hinaus stellt die proportional assistierende Beatmung ( PAV ) eine Beatmungsform dar , bei der nicht nur der Atemwiderstand durch die Beatmungsmaschine in variablem Ausmass kompensiert wird , sondern auch elastische Widerstandkomponenten der Atemarbeit kompensiert werden .
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[ "umlsterm" ]
Ueberdruckbeatmung is an umlsterm, unerwuenschten Nebenwirkungen is an umlsterm, Patient is an umlsterm, Atemarbeit is an umlsterm, Technik is an umlsterm, Atemarbeit is an umlsterm
IntensiveMedizin.90360220.ger.abstr_task1
Sentence: Kontrollierte mechanische Ueberdruckbeatmung hat eine Reihe von unerwuenschten Nebenwirkungen , die durch den Einsatz unterstuetzender Spontanatmungsverfahren teilweise vermieden werden koennen . Deshalb werden heute assistierende Verfahren zur Beatmung eingesetzt , und zwar nicht nur in der Phase der Entwoehnung von der Beatmung , sondern bereits im akuten Krankheitsverlauf . Ziel assistierender Beatmungsformen ist es moeglichst eine optimale Synchronisation zwischen Patient und Maschine und eine Reduzierung der Atemarbeit zu erreichen . Zur Optimierung der bekannten Verfahren wird einerseits eine Technik beschrieben , die den durch den Tubus bedingt erhoehten Atemwiderstand ausgleicht bzw. kompensiert ( automatische Tubuskompensation ( ATC ) ) . Darueber hinaus stellt die proportional assistierende Beatmung ( PAV ) eine Beatmungsform dar , bei der nicht nur der Atemwiderstand durch die Beatmungsmaschine in variablem Ausmass kompensiert wird , sondern auch elastische Widerstandkomponenten der Atemarbeit kompensiert werden . Instructions: please typing these entity words according to sentence: Ueberdruckbeatmung, unerwuenschten Nebenwirkungen, Patient, Atemarbeit, Technik, Atemarbeit Options: umlsterm
[ "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]
Kontrollierte mechanische Ueberdruckbeatmung hat eine Reihe von unerwuenschten Nebenwirkungen , die durch den Einsatz unterstuetzender Spontanatmungsverfahren teilweise vermieden werden koennen . Deshalb werden heute assistierende Verfahren zur Beatmung eingesetzt , und zwar nicht nur in der Phase der Entwoehnung von der Beatmung , sondern bereits im akuten Krankheitsverlauf . Ziel assistierender Beatmungsformen ist es moeglichst eine optimale Synchronisation zwischen Patient und Maschine und eine Reduzierung der Atemarbeit zu erreichen . Zur Optimierung der bekannten Verfahren wird einerseits eine Technik beschrieben , die den durch den Tubus bedingt erhoehten Atemwiderstand ausgleicht bzw. kompensiert ( automatische Tubuskompensation ( ATC ) ) . Darueber hinaus stellt die proportional assistierende Beatmung ( PAV ) eine Beatmungsform dar , bei der nicht nur der Atemwiderstand durch die Beatmungsmaschine in variablem Ausmass kompensiert wird , sondern auch elastische Widerstandkomponenten der Atemarbeit kompensiert werden .
[ "Kontrollierte", "mechanische", "Ueberdruckbeatmung", "hat", "eine", "Reihe", "von", "unerwuenschten", "Nebenwirkungen", ",", "die", "durch", "den", "Einsatz", "unterstuetzender", "Spontanatmungsverfahren", "teilweise", "vermieden", "werden", "koennen", ".", "Deshalb", "werden", "heute", "assistierende", "Verfahren", "zur", "Beatmung", "eingesetzt", ",", "und", "zwar", "nicht", "nur", "in", "der", "Phase", "der", "Entwoehnung", "von", "der", "Beatmung", ",", "sondern", "bereits", "im", "akuten", "Krankheitsverlauf", ".", "Ziel", "assistierender", "Beatmungsformen", "ist", "es", "moeglichst", "eine", "optimale", "Synchronisation", "zwischen", "Patient", "und", "Maschine", "und", "eine", "Reduzierung", "der", "Atemarbeit", "zu", "erreichen", ".", "Zur", "Optimierung", "der", "bekannten", "Verfahren", "wird", "einerseits", "eine", "Technik", "beschrieben", ",", "die", "den", "durch", "den", "Tubus", "bedingt", "erhoehten", "Atemwiderstand", "ausgleicht", "bzw", ".", "kompensiert", "(", "automatische", "Tubuskompensation", "(", "ATC", ")", ")", ".", "Darueber", "hinaus", "stellt", "die", "proportional", "assistierende", "Beatmung", "(", "PAV", ")", "eine", "Beatmungsform", "dar", ",", "bei", "der", "nicht", "nur", "der", "Atemwiderstand", "durch", "die", "Beatmungsmaschine", "in", "variablem", "Ausmass", "kompensiert", "wird", ",", "sondern", "auch", "elastische", "Widerstandkomponenten", "der", "Atemarbeit", "kompensiert", "werden", "." ]
[ "umlsterm" ]
Ueberdruckbeatmung, unerwuenschten Nebenwirkungen, Patient, Atemarbeit, Technik, Atemarbeit
IntensiveMedizin.90360220.ger.abstr_task2
Sentence: Kontrollierte mechanische Ueberdruckbeatmung hat eine Reihe von unerwuenschten Nebenwirkungen , die durch den Einsatz unterstuetzender Spontanatmungsverfahren teilweise vermieden werden koennen . Deshalb werden heute assistierende Verfahren zur Beatmung eingesetzt , und zwar nicht nur in der Phase der Entwoehnung von der Beatmung , sondern bereits im akuten Krankheitsverlauf . Ziel assistierender Beatmungsformen ist es moeglichst eine optimale Synchronisation zwischen Patient und Maschine und eine Reduzierung der Atemarbeit zu erreichen . Zur Optimierung der bekannten Verfahren wird einerseits eine Technik beschrieben , die den durch den Tubus bedingt erhoehten Atemwiderstand ausgleicht bzw. kompensiert ( automatische Tubuskompensation ( ATC ) ) . Darueber hinaus stellt die proportional assistierende Beatmung ( PAV ) eine Beatmungsform dar , bei der nicht nur der Atemwiderstand durch die Beatmungsmaschine in variablem Ausmass kompensiert wird , sondern auch elastische Widerstandkomponenten der Atemarbeit kompensiert werden . Instructions: please extract entity words from the input sentence
[ "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]
Kontrollierte mechanische Ueberdruckbeatmung hat eine Reihe von unerwuenschten Nebenwirkungen , die durch den Einsatz unterstuetzender Spontanatmungsverfahren teilweise vermieden werden koennen . Deshalb werden heute assistierende Verfahren zur Beatmung eingesetzt , und zwar nicht nur in der Phase der Entwoehnung von der Beatmung , sondern bereits im akuten Krankheitsverlauf . Ziel assistierender Beatmungsformen ist es moeglichst eine optimale Synchronisation zwischen Patient und Maschine und eine Reduzierung der Atemarbeit zu erreichen . Zur Optimierung der bekannten Verfahren wird einerseits eine Technik beschrieben , die den durch den Tubus bedingt erhoehten Atemwiderstand ausgleicht bzw. kompensiert ( automatische Tubuskompensation ( ATC ) ) . Darueber hinaus stellt die proportional assistierende Beatmung ( PAV ) eine Beatmungsform dar , bei der nicht nur der Atemwiderstand durch die Beatmungsmaschine in variablem Ausmass kompensiert wird , sondern auch elastische Widerstandkomponenten der Atemarbeit kompensiert werden .
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[ "umlsterm" ]
Everolimus is a CHEMICAL, Exemestane is a CHEMICAL, Hormone Receptor is a GENE-N
23529824_task0
Sentence: Everolimus in Combination with Exemestane: A Review of its Use in the Treatment of Patients with Postmenopausal Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N, CHEMICAL
[ "B-CHEMICAL", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O" ]
Everolimus in Combination with Exemestane: A Review of its Use in the Treatment of Patients with Postmenopausal Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer.
[ "Everolimus", "in", "Combination", "with", "Exemestane", ":", "A", "Review", "of", "its", "Use", "in", "the", "Treatment", "of", "Patients", "with", "Postmenopausal", "Hormone", "Receptor", "-", "Positive", ",", "HER2-Negative", "Advanced", "Breast", "Cancer", "." ]
[ "GENE-Y", "GENE-N", "CHEMICAL" ]
Everolimus is a CHEMICAL, Exemestane is a CHEMICAL, Hormone Receptor is a GENE-N
23529824_task1
Sentence: Everolimus in Combination with Exemestane: A Review of its Use in the Treatment of Patients with Postmenopausal Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer. Instructions: please typing these entity words according to sentence: Everolimus, Exemestane, Hormone Receptor Options: GENE-N, CHEMICAL
[ "B-CHEMICAL", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O" ]
Everolimus in Combination with Exemestane: A Review of its Use in the Treatment of Patients with Postmenopausal Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer.
[ "Everolimus", "in", "Combination", "with", "Exemestane", ":", "A", "Review", "of", "its", "Use", "in", "the", "Treatment", "of", "Patients", "with", "Postmenopausal", "Hormone", "Receptor", "-", "Positive", ",", "HER2-Negative", "Advanced", "Breast", "Cancer", "." ]
[ "GENE-Y", "GENE-N", "CHEMICAL" ]
Everolimus, Exemestane, Hormone Receptor
23529824_task2
Sentence: Everolimus in Combination with Exemestane: A Review of its Use in the Treatment of Patients with Postmenopausal Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer. Instructions: please extract entity words from the input sentence
[ "B-CHEMICAL", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O" ]
Everolimus in Combination with Exemestane: A Review of its Use in the Treatment of Patients with Postmenopausal Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer.
[ "Everolimus", "in", "Combination", "with", "Exemestane", ":", "A", "Review", "of", "its", "Use", "in", "the", "Treatment", "of", "Patients", "with", "Postmenopausal", "Hormone", "Receptor", "-", "Positive", ",", "HER2-Negative", "Advanced", "Breast", "Cancer", "." ]
[ "GENE-Y", "GENE-N", "CHEMICAL" ]
acetylcholinesterase is a Gene, Acetylcholinesterase is a Gene, AChE is a Gene, AChE is a Gene, AChE is a Gene
105_task0
Sentence: The human gene encoding acetylcholinesterase is located on the long arm of chromosome 7. Acetylcholinesterase (AChE) is a secreted enzyme essential for regulating cholinergic neurotransmission at neuronal and neuromuscular synapses. In view of the altered expression of AChE in some central neurological and neuromuscular disorders with a probable genetic basis, we have identified the chromosomal location of the gene encoding AChE. Chromosomal in situ suppression hybridization analysis revealed a single gene to be at 7q22, a result which was confirmed by PCR analysis of genomic DNA from a human/hamster somatic cell hybrid containing a single human chromosome 7. The AChE gene thus maps to the same region in which frequent nonrandom chromosome 7 deletions occur in leukemias of myeloid cell precursors known to express the enzyme during normal differentiation. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Gene
[ "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
The human gene encoding acetylcholinesterase is located on the long arm of chromosome 7. Acetylcholinesterase (AChE) is a secreted enzyme essential for regulating cholinergic neurotransmission at neuronal and neuromuscular synapses. In view of the altered expression of AChE in some central neurological and neuromuscular disorders with a probable genetic basis, we have identified the chromosomal location of the gene encoding AChE. Chromosomal in situ suppression hybridization analysis revealed a single gene to be at 7q22, a result which was confirmed by PCR analysis of genomic DNA from a human/hamster somatic cell hybrid containing a single human chromosome 7. The AChE gene thus maps to the same region in which frequent nonrandom chromosome 7 deletions occur in leukemias of myeloid cell precursors known to express the enzyme during normal differentiation.
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[ "Gene" ]
acetylcholinesterase is a Gene, Acetylcholinesterase is a Gene, AChE is a Gene, AChE is a Gene, AChE is a Gene
105_task1
Sentence: The human gene encoding acetylcholinesterase is located on the long arm of chromosome 7. Acetylcholinesterase (AChE) is a secreted enzyme essential for regulating cholinergic neurotransmission at neuronal and neuromuscular synapses. In view of the altered expression of AChE in some central neurological and neuromuscular disorders with a probable genetic basis, we have identified the chromosomal location of the gene encoding AChE. Chromosomal in situ suppression hybridization analysis revealed a single gene to be at 7q22, a result which was confirmed by PCR analysis of genomic DNA from a human/hamster somatic cell hybrid containing a single human chromosome 7. The AChE gene thus maps to the same region in which frequent nonrandom chromosome 7 deletions occur in leukemias of myeloid cell precursors known to express the enzyme during normal differentiation. Instructions: please typing these entity words according to sentence: acetylcholinesterase, Acetylcholinesterase, AChE, AChE, AChE Options: Gene
[ "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
The human gene encoding acetylcholinesterase is located on the long arm of chromosome 7. Acetylcholinesterase (AChE) is a secreted enzyme essential for regulating cholinergic neurotransmission at neuronal and neuromuscular synapses. In view of the altered expression of AChE in some central neurological and neuromuscular disorders with a probable genetic basis, we have identified the chromosomal location of the gene encoding AChE. Chromosomal in situ suppression hybridization analysis revealed a single gene to be at 7q22, a result which was confirmed by PCR analysis of genomic DNA from a human/hamster somatic cell hybrid containing a single human chromosome 7. The AChE gene thus maps to the same region in which frequent nonrandom chromosome 7 deletions occur in leukemias of myeloid cell precursors known to express the enzyme during normal differentiation.
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[ "Gene" ]
acetylcholinesterase, Acetylcholinesterase, AChE, AChE, AChE
105_task2
Sentence: The human gene encoding acetylcholinesterase is located on the long arm of chromosome 7. Acetylcholinesterase (AChE) is a secreted enzyme essential for regulating cholinergic neurotransmission at neuronal and neuromuscular synapses. In view of the altered expression of AChE in some central neurological and neuromuscular disorders with a probable genetic basis, we have identified the chromosomal location of the gene encoding AChE. Chromosomal in situ suppression hybridization analysis revealed a single gene to be at 7q22, a result which was confirmed by PCR analysis of genomic DNA from a human/hamster somatic cell hybrid containing a single human chromosome 7. The AChE gene thus maps to the same region in which frequent nonrandom chromosome 7 deletions occur in leukemias of myeloid cell precursors known to express the enzyme during normal differentiation. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
The human gene encoding acetylcholinesterase is located on the long arm of chromosome 7. Acetylcholinesterase (AChE) is a secreted enzyme essential for regulating cholinergic neurotransmission at neuronal and neuromuscular synapses. In view of the altered expression of AChE in some central neurological and neuromuscular disorders with a probable genetic basis, we have identified the chromosomal location of the gene encoding AChE. Chromosomal in situ suppression hybridization analysis revealed a single gene to be at 7q22, a result which was confirmed by PCR analysis of genomic DNA from a human/hamster somatic cell hybrid containing a single human chromosome 7. The AChE gene thus maps to the same region in which frequent nonrandom chromosome 7 deletions occur in leukemias of myeloid cell precursors known to express the enzyme during normal differentiation.
[ "The", "human", "gene", "encoding", "acetylcholinesterase", "is", "located", "on", "the", "long", "arm", "of", "chromosome", "7", ".", "Acetylcholinesterase", "(", "AChE", ")", "is", "a", "secreted", "enzyme", "essential", "for", "regulating", "cholinergic", "neurotransmission", "at", "neuronal", "and", "neuromuscular", "synapses", ".", "In", "view", "of", "the", "altered", "expression", "of", "AChE", "in", "some", "central", "neurological", "and", "neuromuscular", "disorders", "with", "a", "probable", "genetic", "basis", ",", "we", "have", "identified", "the", "chromosomal", "location", "of", "the", "gene", "encoding", "AChE.", "Chromosomal", "in", "situ", "suppression", "hybridization", "analysis", "revealed", "a", "single", "gene", "to", "be", "at", "7q22", ",", "a", "result", "which", "was", "confirmed", "by", "PCR", "analysis", "of", "genomic", "DNA", "from", "a", "human", "/", "hamster", "somatic", "cell", "hybrid", "containing", "a", "single", "human", "chromosome", "7", ".", "The", "AChE", "gene", "thus", "maps", "to", "the", "same", "region", "in", "which", "frequent", "nonrandom", "chromosome", "7", "deletions", "occur", "in", "leukemias", "of", "myeloid", "cell", "precursors", "known", "to", "express", "the", "enzyme", "during", "normal", "differentiation", ".", "\n" ]
[ "Gene" ]
zero - balanced ultrafiltration is a Intervention_Physical, modified ultrafiltration is a Intervention_Physical, after cardiac surgery is a Participant_Condition, infants is a Participant_Age, infants ' is a Participant_Age, Sixty is a Participant_Sample-size, congenital heart diseases is a Participant_Condition, 3 groups : a zero - balanced ultrafiltration group ( Z group ) is a Intervention_Physical, a modified ultrafiltration group ( M group ) is a Intervention_Physical, a zero - balanced ultrafiltration with modified ultrafiltration group ( Z+M group ) is a Intervention_Physical
67191_task0
Sentence: [ Effect of zero-balanced ultrafiltration and modified ultrafiltration on pulmonary function after cardiac surgery in infants ] . OBJECTIVE To determine the protective effect of zero-balanced ultrafiltration and modified ultrafiltration on infants ' pulmonary function after cardiac surgery . METHODS Sixty infants with congenital heart diseases were randomly divided into 3 groups : a zero-balanced ultrafiltration group ( Z group ) , a modified ultrafiltration group ( M group ) and a zero-balanced ultrafiltration with modified ultrafiltration group ( Z+M group ) . Oxygenation index ( OI ) , difference of alveoli-arterial oxygen pressure ( P ( A-α ) O2 ) , static lung compliance ( Cstat ) , and airway resistance ( Raw ) were measured before caridopulmonary bypass ( CPB , T1 ) , 20 minutes after the CPB ( T2 ) , 2 h after the operation ( T3 ) , 6 h after the operation ( T4 ) and 12 h after the operation ( T5 ) . The time of mechanical ventilation was also monitored . RESULTS After the CPB , OI and Cstat in all groups decreased significantly , while Raw and P ( A-α ) O2 increased significantly . At T3 , T4 and T5 , OI and Cstat in the Z+M group were significantly higher than those in the Z group and the M group ( P < 0.05 ) , Raw and P ( A-α ) O2 in the Z+M group were significantly lower than those in the Z group and the M group ( P < 0.05 ) . The ventilation time in the Z+M group was significantly shorter than that in the Z group and the M group ( P < 0.05 ) . CONCLUSION Zero-balanced ultrafiltration and modified ultrafiltration can effectively promote the pulmonary function after cardiac surgery in infants . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Physical, Participant_Age, Participant_Condition, Participant_Sample-size
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[ Effect of zero-balanced ultrafiltration and modified ultrafiltration on pulmonary function after cardiac surgery in infants ] . OBJECTIVE To determine the protective effect of zero-balanced ultrafiltration and modified ultrafiltration on infants ' pulmonary function after cardiac surgery . METHODS Sixty infants with congenital heart diseases were randomly divided into 3 groups : a zero-balanced ultrafiltration group ( Z group ) , a modified ultrafiltration group ( M group ) and a zero-balanced ultrafiltration with modified ultrafiltration group ( Z+M group ) . Oxygenation index ( OI ) , difference of alveoli-arterial oxygen pressure ( P ( A-α ) O2 ) , static lung compliance ( Cstat ) , and airway resistance ( Raw ) were measured before caridopulmonary bypass ( CPB , T1 ) , 20 minutes after the CPB ( T2 ) , 2 h after the operation ( T3 ) , 6 h after the operation ( T4 ) and 12 h after the operation ( T5 ) . The time of mechanical ventilation was also monitored . RESULTS After the CPB , OI and Cstat in all groups decreased significantly , while Raw and P ( A-α ) O2 increased significantly . At T3 , T4 and T5 , OI and Cstat in the Z+M group were significantly higher than those in the Z group and the M group ( P < 0.05 ) , Raw and P ( A-α ) O2 in the Z+M group were significantly lower than those in the Z group and the M group ( P < 0.05 ) . The ventilation time in the Z+M group was significantly shorter than that in the Z group and the M group ( P < 0.05 ) . CONCLUSION Zero-balanced ultrafiltration and modified ultrafiltration can effectively promote the pulmonary function after cardiac surgery in infants .
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[ "Intervention_Physical", "Participant_Condition", "Participant_Age", "Participant_Sample-size" ]
zero - balanced ultrafiltration is a Intervention_Physical, modified ultrafiltration is a Intervention_Physical, after cardiac surgery is a Participant_Condition, infants is a Participant_Age, infants ' is a Participant_Age, Sixty is a Participant_Sample-size, congenital heart diseases is a Participant_Condition, 3 groups : a zero - balanced ultrafiltration group ( Z group ) is a Intervention_Physical, a modified ultrafiltration group ( M group ) is a Intervention_Physical, a zero - balanced ultrafiltration with modified ultrafiltration group ( Z+M group ) is a Intervention_Physical
67191_task1
Sentence: [ Effect of zero-balanced ultrafiltration and modified ultrafiltration on pulmonary function after cardiac surgery in infants ] . OBJECTIVE To determine the protective effect of zero-balanced ultrafiltration and modified ultrafiltration on infants ' pulmonary function after cardiac surgery . METHODS Sixty infants with congenital heart diseases were randomly divided into 3 groups : a zero-balanced ultrafiltration group ( Z group ) , a modified ultrafiltration group ( M group ) and a zero-balanced ultrafiltration with modified ultrafiltration group ( Z+M group ) . Oxygenation index ( OI ) , difference of alveoli-arterial oxygen pressure ( P ( A-α ) O2 ) , static lung compliance ( Cstat ) , and airway resistance ( Raw ) were measured before caridopulmonary bypass ( CPB , T1 ) , 20 minutes after the CPB ( T2 ) , 2 h after the operation ( T3 ) , 6 h after the operation ( T4 ) and 12 h after the operation ( T5 ) . The time of mechanical ventilation was also monitored . RESULTS After the CPB , OI and Cstat in all groups decreased significantly , while Raw and P ( A-α ) O2 increased significantly . At T3 , T4 and T5 , OI and Cstat in the Z+M group were significantly higher than those in the Z group and the M group ( P < 0.05 ) , Raw and P ( A-α ) O2 in the Z+M group were significantly lower than those in the Z group and the M group ( P < 0.05 ) . The ventilation time in the Z+M group was significantly shorter than that in the Z group and the M group ( P < 0.05 ) . CONCLUSION Zero-balanced ultrafiltration and modified ultrafiltration can effectively promote the pulmonary function after cardiac surgery in infants . Instructions: please typing these entity words according to sentence: zero - balanced ultrafiltration, modified ultrafiltration, after cardiac surgery, infants, infants ', Sixty, congenital heart diseases, 3 groups : a zero - balanced ultrafiltration group ( Z group ), a modified ultrafiltration group ( M group ), a zero - balanced ultrafiltration with modified ultrafiltration group ( Z+M group ) Options: Intervention_Physical, Participant_Age, Participant_Condition, Participant_Sample-size
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[ Effect of zero-balanced ultrafiltration and modified ultrafiltration on pulmonary function after cardiac surgery in infants ] . OBJECTIVE To determine the protective effect of zero-balanced ultrafiltration and modified ultrafiltration on infants ' pulmonary function after cardiac surgery . METHODS Sixty infants with congenital heart diseases were randomly divided into 3 groups : a zero-balanced ultrafiltration group ( Z group ) , a modified ultrafiltration group ( M group ) and a zero-balanced ultrafiltration with modified ultrafiltration group ( Z+M group ) . Oxygenation index ( OI ) , difference of alveoli-arterial oxygen pressure ( P ( A-α ) O2 ) , static lung compliance ( Cstat ) , and airway resistance ( Raw ) were measured before caridopulmonary bypass ( CPB , T1 ) , 20 minutes after the CPB ( T2 ) , 2 h after the operation ( T3 ) , 6 h after the operation ( T4 ) and 12 h after the operation ( T5 ) . The time of mechanical ventilation was also monitored . RESULTS After the CPB , OI and Cstat in all groups decreased significantly , while Raw and P ( A-α ) O2 increased significantly . At T3 , T4 and T5 , OI and Cstat in the Z+M group were significantly higher than those in the Z group and the M group ( P < 0.05 ) , Raw and P ( A-α ) O2 in the Z+M group were significantly lower than those in the Z group and the M group ( P < 0.05 ) . The ventilation time in the Z+M group was significantly shorter than that in the Z group and the M group ( P < 0.05 ) . CONCLUSION Zero-balanced ultrafiltration and modified ultrafiltration can effectively promote the pulmonary function after cardiac surgery in infants .
[ "[", "Effect", "of", "zero", "-", "balanced", "ultrafiltration", "and", "modified", "ultrafiltration", "on", "pulmonary", "function", "after", "cardiac", "surgery", "in", "infants", "]", ".", "OBJECTIVE", "To", "determine", "the", "protective", "effect", "of", "zero", "-", "balanced", "ultrafiltration", "and", "modified", "ultrafiltration", "on", "infants", "'", "pulmonary", "function", "after", "cardiac", "surgery", ".", "METHODS", "Sixty", "infants", "with", "congenital", "heart", "diseases", "were", "randomly", "divided", "into", "3", "groups", ":", "a", "zero", "-", "balanced", "ultrafiltration", "group", "(", "Z", "group", ")", ",", "a", "modified", "ultrafiltration", "group", "(", "M", "group", ")", "and", "a", "zero", "-", "balanced", "ultrafiltration", "with", "modified", "ultrafiltration", "group", "(", "Z+M", "group", ")", ".", "Oxygenation", "index", "(", "OI", ")", ",", "difference", "of", "alveoli", "-", "arterial", "oxygen", "pressure", "(", "P", "(", "A", "-", "α", ")", "O2", ")", ",", "static", "lung", "compliance", "(", "Cstat", ")", ",", "and", "airway", "resistance", "(", "Raw", ")", "were", "measured", "before", "caridopulmonary", "bypass", "(", "CPB", ",", "T1", ")", ",", "20", "minutes", "after", "the", "CPB", "(", "T2", ")", ",", "2", "h", "after", "the", "operation", "(", "T3", ")", ",", "6", "h", "after", "the", "operation", "(", "T4", ")", "and", "12", "h", "after", "the", "operation", "(", "T5", ")", ".", "The", "time", "of", "mechanical", "ventilation", "was", "also", "monitored", ".", "RESULTS", "After", "the", "CPB", ",", "OI", "and", "Cstat", "in", "all", "groups", "decreased", "significantly", ",", "while", "Raw", "and", "P", "(", "A", "-", "α", ")", "O2", "increased", "significantly", ".", "At", "T3", ",", "T4", "and", "T5", ",", "OI", "and", "Cstat", "in", "the", "Z+M", "group", "were", "significantly", "higher", "than", "those", "in", "the", "Z", "group", "and", "the", "M", "group", "(", "P", "<", "0.05", ")", ",", "Raw", "and", "P", "(", "A", "-", "α", ")", "O2", "in", "the", "Z+M", "group", "were", "significantly", "lower", "than", "those", "in", "the", "Z", "group", "and", "the", "M", "group", "(", "P", "<", "0.05", ")", ".", "The", "ventilation", "time", "in", "the", "Z+M", "group", "was", "significantly", "shorter", "than", "that", "in", "the", "Z", "group", "and", "the", "M", "group", "(", "P", "<", "0.05", ")", ".", "CONCLUSION", "Zero", "-", "balanced", "ultrafiltration", "and", "modified", "ultrafiltration", "can", "effectively", "promote", "the", "pulmonary", "function", "after", "cardiac", "surgery", "in", "infants", "." ]
[ "Intervention_Physical", "Participant_Condition", "Participant_Age", "Participant_Sample-size" ]
zero - balanced ultrafiltration, modified ultrafiltration, after cardiac surgery, infants, infants ', Sixty, congenital heart diseases, 3 groups : a zero - balanced ultrafiltration group ( Z group ), a modified ultrafiltration group ( M group ), a zero - balanced ultrafiltration with modified ultrafiltration group ( Z+M group )
67191_task2
Sentence: [ Effect of zero-balanced ultrafiltration and modified ultrafiltration on pulmonary function after cardiac surgery in infants ] . OBJECTIVE To determine the protective effect of zero-balanced ultrafiltration and modified ultrafiltration on infants ' pulmonary function after cardiac surgery . METHODS Sixty infants with congenital heart diseases were randomly divided into 3 groups : a zero-balanced ultrafiltration group ( Z group ) , a modified ultrafiltration group ( M group ) and a zero-balanced ultrafiltration with modified ultrafiltration group ( Z+M group ) . Oxygenation index ( OI ) , difference of alveoli-arterial oxygen pressure ( P ( A-α ) O2 ) , static lung compliance ( Cstat ) , and airway resistance ( Raw ) were measured before caridopulmonary bypass ( CPB , T1 ) , 20 minutes after the CPB ( T2 ) , 2 h after the operation ( T3 ) , 6 h after the operation ( T4 ) and 12 h after the operation ( T5 ) . The time of mechanical ventilation was also monitored . RESULTS After the CPB , OI and Cstat in all groups decreased significantly , while Raw and P ( A-α ) O2 increased significantly . At T3 , T4 and T5 , OI and Cstat in the Z+M group were significantly higher than those in the Z group and the M group ( P < 0.05 ) , Raw and P ( A-α ) O2 in the Z+M group were significantly lower than those in the Z group and the M group ( P < 0.05 ) . The ventilation time in the Z+M group was significantly shorter than that in the Z group and the M group ( P < 0.05 ) . CONCLUSION Zero-balanced ultrafiltration and modified ultrafiltration can effectively promote the pulmonary function after cardiac surgery in infants . Instructions: please extract entity words from the input sentence
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[ Effect of zero-balanced ultrafiltration and modified ultrafiltration on pulmonary function after cardiac surgery in infants ] . OBJECTIVE To determine the protective effect of zero-balanced ultrafiltration and modified ultrafiltration on infants ' pulmonary function after cardiac surgery . METHODS Sixty infants with congenital heart diseases were randomly divided into 3 groups : a zero-balanced ultrafiltration group ( Z group ) , a modified ultrafiltration group ( M group ) and a zero-balanced ultrafiltration with modified ultrafiltration group ( Z+M group ) . Oxygenation index ( OI ) , difference of alveoli-arterial oxygen pressure ( P ( A-α ) O2 ) , static lung compliance ( Cstat ) , and airway resistance ( Raw ) were measured before caridopulmonary bypass ( CPB , T1 ) , 20 minutes after the CPB ( T2 ) , 2 h after the operation ( T3 ) , 6 h after the operation ( T4 ) and 12 h after the operation ( T5 ) . The time of mechanical ventilation was also monitored . RESULTS After the CPB , OI and Cstat in all groups decreased significantly , while Raw and P ( A-α ) O2 increased significantly . At T3 , T4 and T5 , OI and Cstat in the Z+M group were significantly higher than those in the Z group and the M group ( P < 0.05 ) , Raw and P ( A-α ) O2 in the Z+M group were significantly lower than those in the Z group and the M group ( P < 0.05 ) . The ventilation time in the Z+M group was significantly shorter than that in the Z group and the M group ( P < 0.05 ) . CONCLUSION Zero-balanced ultrafiltration and modified ultrafiltration can effectively promote the pulmonary function after cardiac surgery in infants .
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[ "Intervention_Physical", "Participant_Condition", "Participant_Age", "Participant_Sample-size" ]
mu and kappa opioid receptor is a GENE-N, Opioid receptors is a GENE-N, morphine is a CHEMICAL, fentanyl is a CHEMICAL, endogenous opioid peptides is a GENE-N, enkephalins is a CHEMICAL, endorphins is a GENE-N, mu and the kappa opioid receptors is a GENE-N, mu receptor is a GENE-Y, Oprm is a GENE-Y, kappa receptor is a GENE-Y, Oprk1 is a GENE-Y, opioid receptors is a GENE-N
10719_task0
Sentence: Murine chromosomal location of the mu and kappa opioid receptor genes. Opioid receptors are the membrane proteins that mediate the pain-relieving effect of opioid drugs, such as morphine and fentanyl as well as endogenous opioid peptides enkephalins and endorphins. Using cDNAs for the mu and the kappa opioid receptors, we mapped the chromosomal locations of their genes in mouse. Multilocus cross analysis located the mu receptor gene Oprm on Chr 10 and the kappa receptor gene Oprk1 on Chr 1. Both genes are near centromere, with no markers more centromeric. These data indicate that the two opioid receptors are different gene products, ruling out the possibility that they may be differential splicing products from the same gene. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, GENE-N, CHEMICAL
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Murine chromosomal location of the mu and kappa opioid receptor genes. Opioid receptors are the membrane proteins that mediate the pain-relieving effect of opioid drugs, such as morphine and fentanyl as well as endogenous opioid peptides enkephalins and endorphins. Using cDNAs for the mu and the kappa opioid receptors, we mapped the chromosomal locations of their genes in mouse. Multilocus cross analysis located the mu receptor gene Oprm on Chr 10 and the kappa receptor gene Oprk1 on Chr 1. Both genes are near centromere, with no markers more centromeric. These data indicate that the two opioid receptors are different gene products, ruling out the possibility that they may be differential splicing products from the same gene.
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[ "GENE-N", "GENE-Y", "CHEMICAL" ]
mu and kappa opioid receptor is a GENE-N, Opioid receptors is a GENE-N, morphine is a CHEMICAL, fentanyl is a CHEMICAL, endogenous opioid peptides is a GENE-N, enkephalins is a CHEMICAL, endorphins is a GENE-N, mu and the kappa opioid receptors is a GENE-N, mu receptor is a GENE-Y, Oprm is a GENE-Y, kappa receptor is a GENE-Y, Oprk1 is a GENE-Y, opioid receptors is a GENE-N
10719_task1
Sentence: Murine chromosomal location of the mu and kappa opioid receptor genes. Opioid receptors are the membrane proteins that mediate the pain-relieving effect of opioid drugs, such as morphine and fentanyl as well as endogenous opioid peptides enkephalins and endorphins. Using cDNAs for the mu and the kappa opioid receptors, we mapped the chromosomal locations of their genes in mouse. Multilocus cross analysis located the mu receptor gene Oprm on Chr 10 and the kappa receptor gene Oprk1 on Chr 1. Both genes are near centromere, with no markers more centromeric. These data indicate that the two opioid receptors are different gene products, ruling out the possibility that they may be differential splicing products from the same gene. Instructions: please typing these entity words according to sentence: mu and kappa opioid receptor, Opioid receptors, morphine, fentanyl, endogenous opioid peptides, enkephalins, endorphins, mu and the kappa opioid receptors, mu receptor, Oprm, kappa receptor, Oprk1, opioid receptors Options: GENE-Y, GENE-N, CHEMICAL
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Murine chromosomal location of the mu and kappa opioid receptor genes. Opioid receptors are the membrane proteins that mediate the pain-relieving effect of opioid drugs, such as morphine and fentanyl as well as endogenous opioid peptides enkephalins and endorphins. Using cDNAs for the mu and the kappa opioid receptors, we mapped the chromosomal locations of their genes in mouse. Multilocus cross analysis located the mu receptor gene Oprm on Chr 10 and the kappa receptor gene Oprk1 on Chr 1. Both genes are near centromere, with no markers more centromeric. These data indicate that the two opioid receptors are different gene products, ruling out the possibility that they may be differential splicing products from the same gene.
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[ "GENE-N", "GENE-Y", "CHEMICAL" ]
mu and kappa opioid receptor, Opioid receptors, morphine, fentanyl, endogenous opioid peptides, enkephalins, endorphins, mu and the kappa opioid receptors, mu receptor, Oprm, kappa receptor, Oprk1, opioid receptors
10719_task2
Sentence: Murine chromosomal location of the mu and kappa opioid receptor genes. Opioid receptors are the membrane proteins that mediate the pain-relieving effect of opioid drugs, such as morphine and fentanyl as well as endogenous opioid peptides enkephalins and endorphins. Using cDNAs for the mu and the kappa opioid receptors, we mapped the chromosomal locations of their genes in mouse. Multilocus cross analysis located the mu receptor gene Oprm on Chr 10 and the kappa receptor gene Oprk1 on Chr 1. Both genes are near centromere, with no markers more centromeric. These data indicate that the two opioid receptors are different gene products, ruling out the possibility that they may be differential splicing products from the same gene. Instructions: please extract entity words from the input sentence
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Murine chromosomal location of the mu and kappa opioid receptor genes. Opioid receptors are the membrane proteins that mediate the pain-relieving effect of opioid drugs, such as morphine and fentanyl as well as endogenous opioid peptides enkephalins and endorphins. Using cDNAs for the mu and the kappa opioid receptors, we mapped the chromosomal locations of their genes in mouse. Multilocus cross analysis located the mu receptor gene Oprm on Chr 10 and the kappa receptor gene Oprk1 on Chr 1. Both genes are near centromere, with no markers more centromeric. These data indicate that the two opioid receptors are different gene products, ruling out the possibility that they may be differential splicing products from the same gene.
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[ "GENE-N", "GENE-Y", "CHEMICAL" ]
cervical intraepithelial neoplasia is a Participant_Condition, human papillomavirus ( HPV ) is a Outcome_Physical, women is a Participant_Sex, CIN3 is a Participant_Condition, cervical precancer is a Participant_Condition, equivocal ( ASCUS ) or mildly abnormal ( LSIL ) Pap tests is a Participant_Condition, 608 is a Participant_Sample-size, PCR - based HPV genotyping results is a Intervention_Physical, carcinogenic HPV . HPV16 is a Outcome_Physical, HPV31 is a Outcome_Physical, HPV52 is a Outcome_Physical, HPV51 is a Outcome_Physical, HPV18 is a Outcome_Physical, Younger age , consensus histologic confirmation is a Outcome_Physical, testing HPV 16 positive is a Outcome_Physical, HPV16-positive CIN3 is a Outcome_Physical, CIN3 positive is a Outcome_Physical, carcinogenic HPV genotypes is a Outcome_Physical, HPV16 ( and HPV18 ) is a Intervention_Physical
46539_task0
Sentence: Human papillomavirus genotypes in cervical intraepithelial neoplasia grade 3 . BACKGROUND There are few large case series describing the human papillomavirus ( HPV ) genotypes found in women diagnosed with rigorously reviewed cervical intraepithelial neoplasia grade 3 ( CIN3 ) , cervical precancer . METHODS The Atypical Squamous Cells of Undetermined Significance ( ASCUS ) and Low-Grade Squamous Intraepithelial Lesion ( LSIL ) Triage Study ( ALTS ) was a clinical trial to evaluate the best management strategies for women with equivocal ( ASCUS ) or mildly abnormal ( LSIL ) Pap tests . During enrollment and the 2-year follow-up , 608 women had a histopathologic diagnosis of CIN3 and PCR-based HPV genotyping results on cervical specimens . The genotyping results were ranked hierarchically according to cancer risk : HPV16 > other carcinogenic HPV > noncarcinogenic HPV > PCR negative . RESULTS Among the 608 women diagnosed with CIN3 , 601 ( 98.8 % ) cases were positive for any HPV genotype and 95.4 % for any carcinogenic HPV . HPV16 ( 59.9 % ) , HPV31 ( 18.1 % ) , HPV52 ( 14.8 % ) , HPV51 ( 14.0 % ) , and HPV18 ( 13.2 % ) were the five most common HPV genotypes detected . Younger age , consensus histologic confirmation , smoking , and multiparity increased the likelihood of testing HPV 16 positive . Specifically , HPV16-positive CIN3 occurred at a younger age than CIN3 positive for other carcinogenic HPV genotypes ( median of 23.5 years versus 25 years , respectively ; P = 0.0003 , Kruskal-Wallis ) . CONCLUSIONS HPV16-positive CIN3 was more commonly diagnosed in younger women ( versus older women ) , with consensus diagnosis ( versus some disagreement between reviewers ) , and in smokers ( versus nonsmokers ) , and was less commonly diagnosed in multiparous women compared CIN3 positive for other carcinogenic HPV genotypes . IMPACT In populations vaccinated against HPV16 ( and HPV18 ) , the median age of CIN3 in women with ASCUS and LSIL cytology should shift to older ages , possibly permitting later age at first screening . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Physical, Participant_Sex, Participant_Condition, Outcome_Physical, Participant_Sample-size
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Human papillomavirus genotypes in cervical intraepithelial neoplasia grade 3 . BACKGROUND There are few large case series describing the human papillomavirus ( HPV ) genotypes found in women diagnosed with rigorously reviewed cervical intraepithelial neoplasia grade 3 ( CIN3 ) , cervical precancer . METHODS The Atypical Squamous Cells of Undetermined Significance ( ASCUS ) and Low-Grade Squamous Intraepithelial Lesion ( LSIL ) Triage Study ( ALTS ) was a clinical trial to evaluate the best management strategies for women with equivocal ( ASCUS ) or mildly abnormal ( LSIL ) Pap tests . During enrollment and the 2-year follow-up , 608 women had a histopathologic diagnosis of CIN3 and PCR-based HPV genotyping results on cervical specimens . The genotyping results were ranked hierarchically according to cancer risk : HPV16 > other carcinogenic HPV > noncarcinogenic HPV > PCR negative . RESULTS Among the 608 women diagnosed with CIN3 , 601 ( 98.8 % ) cases were positive for any HPV genotype and 95.4 % for any carcinogenic HPV . HPV16 ( 59.9 % ) , HPV31 ( 18.1 % ) , HPV52 ( 14.8 % ) , HPV51 ( 14.0 % ) , and HPV18 ( 13.2 % ) were the five most common HPV genotypes detected . Younger age , consensus histologic confirmation , smoking , and multiparity increased the likelihood of testing HPV 16 positive . Specifically , HPV16-positive CIN3 occurred at a younger age than CIN3 positive for other carcinogenic HPV genotypes ( median of 23.5 years versus 25 years , respectively ; P = 0.0003 , Kruskal-Wallis ) . CONCLUSIONS HPV16-positive CIN3 was more commonly diagnosed in younger women ( versus older women ) , with consensus diagnosis ( versus some disagreement between reviewers ) , and in smokers ( versus nonsmokers ) , and was less commonly diagnosed in multiparous women compared CIN3 positive for other carcinogenic HPV genotypes . IMPACT In populations vaccinated against HPV16 ( and HPV18 ) , the median age of CIN3 in women with ASCUS and LSIL cytology should shift to older ages , possibly permitting later age at first screening .
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[ "Participant_Condition", "Outcome_Physical", "Intervention_Physical", "Participant_Sex", "Participant_Sample-size" ]
cervical intraepithelial neoplasia is a Participant_Condition, human papillomavirus ( HPV ) is a Outcome_Physical, women is a Participant_Sex, CIN3 is a Participant_Condition, cervical precancer is a Participant_Condition, equivocal ( ASCUS ) or mildly abnormal ( LSIL ) Pap tests is a Participant_Condition, 608 is a Participant_Sample-size, PCR - based HPV genotyping results is a Intervention_Physical, carcinogenic HPV . HPV16 is a Outcome_Physical, HPV31 is a Outcome_Physical, HPV52 is a Outcome_Physical, HPV51 is a Outcome_Physical, HPV18 is a Outcome_Physical, Younger age , consensus histologic confirmation is a Outcome_Physical, testing HPV 16 positive is a Outcome_Physical, HPV16-positive CIN3 is a Outcome_Physical, CIN3 positive is a Outcome_Physical, carcinogenic HPV genotypes is a Outcome_Physical, HPV16 ( and HPV18 ) is a Intervention_Physical
46539_task1
Sentence: Human papillomavirus genotypes in cervical intraepithelial neoplasia grade 3 . BACKGROUND There are few large case series describing the human papillomavirus ( HPV ) genotypes found in women diagnosed with rigorously reviewed cervical intraepithelial neoplasia grade 3 ( CIN3 ) , cervical precancer . METHODS The Atypical Squamous Cells of Undetermined Significance ( ASCUS ) and Low-Grade Squamous Intraepithelial Lesion ( LSIL ) Triage Study ( ALTS ) was a clinical trial to evaluate the best management strategies for women with equivocal ( ASCUS ) or mildly abnormal ( LSIL ) Pap tests . During enrollment and the 2-year follow-up , 608 women had a histopathologic diagnosis of CIN3 and PCR-based HPV genotyping results on cervical specimens . The genotyping results were ranked hierarchically according to cancer risk : HPV16 > other carcinogenic HPV > noncarcinogenic HPV > PCR negative . RESULTS Among the 608 women diagnosed with CIN3 , 601 ( 98.8 % ) cases were positive for any HPV genotype and 95.4 % for any carcinogenic HPV . HPV16 ( 59.9 % ) , HPV31 ( 18.1 % ) , HPV52 ( 14.8 % ) , HPV51 ( 14.0 % ) , and HPV18 ( 13.2 % ) were the five most common HPV genotypes detected . Younger age , consensus histologic confirmation , smoking , and multiparity increased the likelihood of testing HPV 16 positive . Specifically , HPV16-positive CIN3 occurred at a younger age than CIN3 positive for other carcinogenic HPV genotypes ( median of 23.5 years versus 25 years , respectively ; P = 0.0003 , Kruskal-Wallis ) . CONCLUSIONS HPV16-positive CIN3 was more commonly diagnosed in younger women ( versus older women ) , with consensus diagnosis ( versus some disagreement between reviewers ) , and in smokers ( versus nonsmokers ) , and was less commonly diagnosed in multiparous women compared CIN3 positive for other carcinogenic HPV genotypes . IMPACT In populations vaccinated against HPV16 ( and HPV18 ) , the median age of CIN3 in women with ASCUS and LSIL cytology should shift to older ages , possibly permitting later age at first screening . Instructions: please typing these entity words according to sentence: cervical intraepithelial neoplasia, human papillomavirus ( HPV ), women, CIN3, cervical precancer, equivocal ( ASCUS ) or mildly abnormal ( LSIL ) Pap tests, 608, PCR - based HPV genotyping results, carcinogenic HPV . HPV16, HPV31, HPV52, HPV51, HPV18, Younger age , consensus histologic confirmation, testing HPV 16 positive, HPV16-positive CIN3, CIN3 positive, carcinogenic HPV genotypes, HPV16 ( and HPV18 ) Options: Intervention_Physical, Participant_Sex, Participant_Condition, Outcome_Physical, Participant_Sample-size
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Human papillomavirus genotypes in cervical intraepithelial neoplasia grade 3 . BACKGROUND There are few large case series describing the human papillomavirus ( HPV ) genotypes found in women diagnosed with rigorously reviewed cervical intraepithelial neoplasia grade 3 ( CIN3 ) , cervical precancer . METHODS The Atypical Squamous Cells of Undetermined Significance ( ASCUS ) and Low-Grade Squamous Intraepithelial Lesion ( LSIL ) Triage Study ( ALTS ) was a clinical trial to evaluate the best management strategies for women with equivocal ( ASCUS ) or mildly abnormal ( LSIL ) Pap tests . During enrollment and the 2-year follow-up , 608 women had a histopathologic diagnosis of CIN3 and PCR-based HPV genotyping results on cervical specimens . The genotyping results were ranked hierarchically according to cancer risk : HPV16 > other carcinogenic HPV > noncarcinogenic HPV > PCR negative . RESULTS Among the 608 women diagnosed with CIN3 , 601 ( 98.8 % ) cases were positive for any HPV genotype and 95.4 % for any carcinogenic HPV . HPV16 ( 59.9 % ) , HPV31 ( 18.1 % ) , HPV52 ( 14.8 % ) , HPV51 ( 14.0 % ) , and HPV18 ( 13.2 % ) were the five most common HPV genotypes detected . Younger age , consensus histologic confirmation , smoking , and multiparity increased the likelihood of testing HPV 16 positive . Specifically , HPV16-positive CIN3 occurred at a younger age than CIN3 positive for other carcinogenic HPV genotypes ( median of 23.5 years versus 25 years , respectively ; P = 0.0003 , Kruskal-Wallis ) . CONCLUSIONS HPV16-positive CIN3 was more commonly diagnosed in younger women ( versus older women ) , with consensus diagnosis ( versus some disagreement between reviewers ) , and in smokers ( versus nonsmokers ) , and was less commonly diagnosed in multiparous women compared CIN3 positive for other carcinogenic HPV genotypes . IMPACT In populations vaccinated against HPV16 ( and HPV18 ) , the median age of CIN3 in women with ASCUS and LSIL cytology should shift to older ages , possibly permitting later age at first screening .
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[ "Participant_Condition", "Outcome_Physical", "Intervention_Physical", "Participant_Sex", "Participant_Sample-size" ]
cervical intraepithelial neoplasia, human papillomavirus ( HPV ), women, CIN3, cervical precancer, equivocal ( ASCUS ) or mildly abnormal ( LSIL ) Pap tests, 608, PCR - based HPV genotyping results, carcinogenic HPV . HPV16, HPV31, HPV52, HPV51, HPV18, Younger age , consensus histologic confirmation, testing HPV 16 positive, HPV16-positive CIN3, CIN3 positive, carcinogenic HPV genotypes, HPV16 ( and HPV18 )
46539_task2
Sentence: Human papillomavirus genotypes in cervical intraepithelial neoplasia grade 3 . BACKGROUND There are few large case series describing the human papillomavirus ( HPV ) genotypes found in women diagnosed with rigorously reviewed cervical intraepithelial neoplasia grade 3 ( CIN3 ) , cervical precancer . METHODS The Atypical Squamous Cells of Undetermined Significance ( ASCUS ) and Low-Grade Squamous Intraepithelial Lesion ( LSIL ) Triage Study ( ALTS ) was a clinical trial to evaluate the best management strategies for women with equivocal ( ASCUS ) or mildly abnormal ( LSIL ) Pap tests . During enrollment and the 2-year follow-up , 608 women had a histopathologic diagnosis of CIN3 and PCR-based HPV genotyping results on cervical specimens . The genotyping results were ranked hierarchically according to cancer risk : HPV16 > other carcinogenic HPV > noncarcinogenic HPV > PCR negative . RESULTS Among the 608 women diagnosed with CIN3 , 601 ( 98.8 % ) cases were positive for any HPV genotype and 95.4 % for any carcinogenic HPV . HPV16 ( 59.9 % ) , HPV31 ( 18.1 % ) , HPV52 ( 14.8 % ) , HPV51 ( 14.0 % ) , and HPV18 ( 13.2 % ) were the five most common HPV genotypes detected . Younger age , consensus histologic confirmation , smoking , and multiparity increased the likelihood of testing HPV 16 positive . Specifically , HPV16-positive CIN3 occurred at a younger age than CIN3 positive for other carcinogenic HPV genotypes ( median of 23.5 years versus 25 years , respectively ; P = 0.0003 , Kruskal-Wallis ) . CONCLUSIONS HPV16-positive CIN3 was more commonly diagnosed in younger women ( versus older women ) , with consensus diagnosis ( versus some disagreement between reviewers ) , and in smokers ( versus nonsmokers ) , and was less commonly diagnosed in multiparous women compared CIN3 positive for other carcinogenic HPV genotypes . IMPACT In populations vaccinated against HPV16 ( and HPV18 ) , the median age of CIN3 in women with ASCUS and LSIL cytology should shift to older ages , possibly permitting later age at first screening . Instructions: please extract entity words from the input sentence
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Human papillomavirus genotypes in cervical intraepithelial neoplasia grade 3 . BACKGROUND There are few large case series describing the human papillomavirus ( HPV ) genotypes found in women diagnosed with rigorously reviewed cervical intraepithelial neoplasia grade 3 ( CIN3 ) , cervical precancer . METHODS The Atypical Squamous Cells of Undetermined Significance ( ASCUS ) and Low-Grade Squamous Intraepithelial Lesion ( LSIL ) Triage Study ( ALTS ) was a clinical trial to evaluate the best management strategies for women with equivocal ( ASCUS ) or mildly abnormal ( LSIL ) Pap tests . During enrollment and the 2-year follow-up , 608 women had a histopathologic diagnosis of CIN3 and PCR-based HPV genotyping results on cervical specimens . The genotyping results were ranked hierarchically according to cancer risk : HPV16 > other carcinogenic HPV > noncarcinogenic HPV > PCR negative . RESULTS Among the 608 women diagnosed with CIN3 , 601 ( 98.8 % ) cases were positive for any HPV genotype and 95.4 % for any carcinogenic HPV . HPV16 ( 59.9 % ) , HPV31 ( 18.1 % ) , HPV52 ( 14.8 % ) , HPV51 ( 14.0 % ) , and HPV18 ( 13.2 % ) were the five most common HPV genotypes detected . Younger age , consensus histologic confirmation , smoking , and multiparity increased the likelihood of testing HPV 16 positive . Specifically , HPV16-positive CIN3 occurred at a younger age than CIN3 positive for other carcinogenic HPV genotypes ( median of 23.5 years versus 25 years , respectively ; P = 0.0003 , Kruskal-Wallis ) . CONCLUSIONS HPV16-positive CIN3 was more commonly diagnosed in younger women ( versus older women ) , with consensus diagnosis ( versus some disagreement between reviewers ) , and in smokers ( versus nonsmokers ) , and was less commonly diagnosed in multiparous women compared CIN3 positive for other carcinogenic HPV genotypes . IMPACT In populations vaccinated against HPV16 ( and HPV18 ) , the median age of CIN3 in women with ASCUS and LSIL cytology should shift to older ages , possibly permitting later age at first screening .
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[ "Participant_Condition", "Outcome_Physical", "Intervention_Physical", "Participant_Sex", "Participant_Sample-size" ]
Tailored , iterative , printed dietary feedback is a Intervention_Educational, middle - aged adults is a Participant_Age, cardiovascular risk factors is a Participant_Condition, tailored , iterative , printed dietary feedback ( TF ) is a Intervention_Educational, nutrition education sessions is a Intervention_Educational, dietary measures and socio - demographic questionnaires is a Intervention_Educational, saturated fat intake ( g ) is a Outcome_Mental, intake of fruit ( serves ) , vegetables ( serves ) , grain and cereals is a Outcome_Mental, total and wholegrain ( serves ) is a Outcome_Mental, fruit intake is a Outcome_Mental, total saturated fat intake is a Outcome_Mental, mean vegetable intake is a Outcome_Mental
50335_task0
Sentence: Tailored , iterative , printed dietary feedback is as effective as group education in improving dietary behaviours : results from a randomised control trial in middle-aged adults with cardiovascular risk factors . BACKGROUND Tailored nutrition interventions have been shown to be more effective than non-tailored materials in changing dietary behaviours , particularly fat intake and fruit and vegetable intake . But further research examining efficacy of tailored nutrition education in comparison to other nutrition education methods and across a wider range of dietary behaviours is needed . The Stages to Healthy Eating Patterns Study ( STEPs ) was an intervention study , in middle-aged adults with cardiovascular risk factors , to examine the effectiveness of printed , tailored , iterative dietary feedback delivered by mail in improving short-term dietary behaviour in the areas of saturated fat , fruit , vegetable and grain and cereal intake . METHODS STEPs was a 3-month randomised controlled trial with a pre and post-test design . There were three experimental conditions : 1 ) tailored , iterative , printed dietary feedback ( TF ) with three instalments mail-delivered over a 3-month period that were re-tailored to most recent assessment of dietary intake , intention to change and assessment of self-adequacy of dietary intake . Tailoring for dietary intake was performed on data from a validated 63-item combination FFQ designed for the purpose 2 ) small group nutrition education sessions ( GE ) : consisting of two 90-minute dietitian-led small group nutrition education sessions and 3 ) and a wait-listed control ( C ) group who completed the dietary measures and socio-demographic questionnaires at baseline and 3-months later . Dietary outcome measures in the areas of saturated fat intake ( g ) , and the intake of fruit ( serves ) , vegetables ( serves ) , grain and cereals as total and wholegrain ( serves ) were collected using 7-day estimated dietary records . Descriptive statistics , paired t-tests and general linear models adjusted for baseline dietary intake , age and gender were used to examine the effectiveness of different nutrition interventions . RESULTS The TF group reported a significantly greater increase in fruit intake ( 0.3 serves/d P = 0.031 ) in comparison to GE and the C group . All three intervention groups showed a reduction in total saturated fat intake . GE also had a within-group increase in mean vegetable intake after 3 months , but this increase was not different from changes in the other groups . CONCLUSIONS In this study , printed , tailored , iterative dietary feedback was more effective than small group nutrition education in improving the short-term fruit intake behaviour , and as effective in improving saturated fat intake of middle-aged adults with cardiovascular risk factors . This showed that a low-level dietary intervention could achieve modest dietary behaviour changes that are of public health significance . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Educational, Participant_Age, Participant_Condition, Outcome_Mental
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Tailored , iterative , printed dietary feedback is as effective as group education in improving dietary behaviours : results from a randomised control trial in middle-aged adults with cardiovascular risk factors . BACKGROUND Tailored nutrition interventions have been shown to be more effective than non-tailored materials in changing dietary behaviours , particularly fat intake and fruit and vegetable intake . But further research examining efficacy of tailored nutrition education in comparison to other nutrition education methods and across a wider range of dietary behaviours is needed . The Stages to Healthy Eating Patterns Study ( STEPs ) was an intervention study , in middle-aged adults with cardiovascular risk factors , to examine the effectiveness of printed , tailored , iterative dietary feedback delivered by mail in improving short-term dietary behaviour in the areas of saturated fat , fruit , vegetable and grain and cereal intake . METHODS STEPs was a 3-month randomised controlled trial with a pre and post-test design . There were three experimental conditions : 1 ) tailored , iterative , printed dietary feedback ( TF ) with three instalments mail-delivered over a 3-month period that were re-tailored to most recent assessment of dietary intake , intention to change and assessment of self-adequacy of dietary intake . Tailoring for dietary intake was performed on data from a validated 63-item combination FFQ designed for the purpose 2 ) small group nutrition education sessions ( GE ) : consisting of two 90-minute dietitian-led small group nutrition education sessions and 3 ) and a wait-listed control ( C ) group who completed the dietary measures and socio-demographic questionnaires at baseline and 3-months later . Dietary outcome measures in the areas of saturated fat intake ( g ) , and the intake of fruit ( serves ) , vegetables ( serves ) , grain and cereals as total and wholegrain ( serves ) were collected using 7-day estimated dietary records . Descriptive statistics , paired t-tests and general linear models adjusted for baseline dietary intake , age and gender were used to examine the effectiveness of different nutrition interventions . RESULTS The TF group reported a significantly greater increase in fruit intake ( 0.3 serves/d P = 0.031 ) in comparison to GE and the C group . All three intervention groups showed a reduction in total saturated fat intake . GE also had a within-group increase in mean vegetable intake after 3 months , but this increase was not different from changes in the other groups . CONCLUSIONS In this study , printed , tailored , iterative dietary feedback was more effective than small group nutrition education in improving the short-term fruit intake behaviour , and as effective in improving saturated fat intake of middle-aged adults with cardiovascular risk factors . This showed that a low-level dietary intervention could achieve modest dietary behaviour changes that are of public health significance .
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[ "Outcome_Mental", "Intervention_Educational", "Participant_Condition", "Participant_Age" ]
Tailored , iterative , printed dietary feedback is a Intervention_Educational, middle - aged adults is a Participant_Age, cardiovascular risk factors is a Participant_Condition, tailored , iterative , printed dietary feedback ( TF ) is a Intervention_Educational, nutrition education sessions is a Intervention_Educational, dietary measures and socio - demographic questionnaires is a Intervention_Educational, saturated fat intake ( g ) is a Outcome_Mental, intake of fruit ( serves ) , vegetables ( serves ) , grain and cereals is a Outcome_Mental, total and wholegrain ( serves ) is a Outcome_Mental, fruit intake is a Outcome_Mental, total saturated fat intake is a Outcome_Mental, mean vegetable intake is a Outcome_Mental
50335_task1
Sentence: Tailored , iterative , printed dietary feedback is as effective as group education in improving dietary behaviours : results from a randomised control trial in middle-aged adults with cardiovascular risk factors . BACKGROUND Tailored nutrition interventions have been shown to be more effective than non-tailored materials in changing dietary behaviours , particularly fat intake and fruit and vegetable intake . But further research examining efficacy of tailored nutrition education in comparison to other nutrition education methods and across a wider range of dietary behaviours is needed . The Stages to Healthy Eating Patterns Study ( STEPs ) was an intervention study , in middle-aged adults with cardiovascular risk factors , to examine the effectiveness of printed , tailored , iterative dietary feedback delivered by mail in improving short-term dietary behaviour in the areas of saturated fat , fruit , vegetable and grain and cereal intake . METHODS STEPs was a 3-month randomised controlled trial with a pre and post-test design . There were three experimental conditions : 1 ) tailored , iterative , printed dietary feedback ( TF ) with three instalments mail-delivered over a 3-month period that were re-tailored to most recent assessment of dietary intake , intention to change and assessment of self-adequacy of dietary intake . Tailoring for dietary intake was performed on data from a validated 63-item combination FFQ designed for the purpose 2 ) small group nutrition education sessions ( GE ) : consisting of two 90-minute dietitian-led small group nutrition education sessions and 3 ) and a wait-listed control ( C ) group who completed the dietary measures and socio-demographic questionnaires at baseline and 3-months later . Dietary outcome measures in the areas of saturated fat intake ( g ) , and the intake of fruit ( serves ) , vegetables ( serves ) , grain and cereals as total and wholegrain ( serves ) were collected using 7-day estimated dietary records . Descriptive statistics , paired t-tests and general linear models adjusted for baseline dietary intake , age and gender were used to examine the effectiveness of different nutrition interventions . RESULTS The TF group reported a significantly greater increase in fruit intake ( 0.3 serves/d P = 0.031 ) in comparison to GE and the C group . All three intervention groups showed a reduction in total saturated fat intake . GE also had a within-group increase in mean vegetable intake after 3 months , but this increase was not different from changes in the other groups . CONCLUSIONS In this study , printed , tailored , iterative dietary feedback was more effective than small group nutrition education in improving the short-term fruit intake behaviour , and as effective in improving saturated fat intake of middle-aged adults with cardiovascular risk factors . This showed that a low-level dietary intervention could achieve modest dietary behaviour changes that are of public health significance . Instructions: please typing these entity words according to sentence: Tailored , iterative , printed dietary feedback, middle - aged adults, cardiovascular risk factors, tailored , iterative , printed dietary feedback ( TF ), nutrition education sessions, dietary measures and socio - demographic questionnaires, saturated fat intake ( g ), intake of fruit ( serves ) , vegetables ( serves ) , grain and cereals, total and wholegrain ( serves ), fruit intake, total saturated fat intake, mean vegetable intake Options: Intervention_Educational, Participant_Age, Participant_Condition, Outcome_Mental
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Tailored , iterative , printed dietary feedback is as effective as group education in improving dietary behaviours : results from a randomised control trial in middle-aged adults with cardiovascular risk factors . BACKGROUND Tailored nutrition interventions have been shown to be more effective than non-tailored materials in changing dietary behaviours , particularly fat intake and fruit and vegetable intake . But further research examining efficacy of tailored nutrition education in comparison to other nutrition education methods and across a wider range of dietary behaviours is needed . The Stages to Healthy Eating Patterns Study ( STEPs ) was an intervention study , in middle-aged adults with cardiovascular risk factors , to examine the effectiveness of printed , tailored , iterative dietary feedback delivered by mail in improving short-term dietary behaviour in the areas of saturated fat , fruit , vegetable and grain and cereal intake . METHODS STEPs was a 3-month randomised controlled trial with a pre and post-test design . There were three experimental conditions : 1 ) tailored , iterative , printed dietary feedback ( TF ) with three instalments mail-delivered over a 3-month period that were re-tailored to most recent assessment of dietary intake , intention to change and assessment of self-adequacy of dietary intake . Tailoring for dietary intake was performed on data from a validated 63-item combination FFQ designed for the purpose 2 ) small group nutrition education sessions ( GE ) : consisting of two 90-minute dietitian-led small group nutrition education sessions and 3 ) and a wait-listed control ( C ) group who completed the dietary measures and socio-demographic questionnaires at baseline and 3-months later . Dietary outcome measures in the areas of saturated fat intake ( g ) , and the intake of fruit ( serves ) , vegetables ( serves ) , grain and cereals as total and wholegrain ( serves ) were collected using 7-day estimated dietary records . Descriptive statistics , paired t-tests and general linear models adjusted for baseline dietary intake , age and gender were used to examine the effectiveness of different nutrition interventions . RESULTS The TF group reported a significantly greater increase in fruit intake ( 0.3 serves/d P = 0.031 ) in comparison to GE and the C group . All three intervention groups showed a reduction in total saturated fat intake . GE also had a within-group increase in mean vegetable intake after 3 months , but this increase was not different from changes in the other groups . CONCLUSIONS In this study , printed , tailored , iterative dietary feedback was more effective than small group nutrition education in improving the short-term fruit intake behaviour , and as effective in improving saturated fat intake of middle-aged adults with cardiovascular risk factors . This showed that a low-level dietary intervention could achieve modest dietary behaviour changes that are of public health significance .
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[ "Outcome_Mental", "Intervention_Educational", "Participant_Condition", "Participant_Age" ]
Tailored , iterative , printed dietary feedback, middle - aged adults, cardiovascular risk factors, tailored , iterative , printed dietary feedback ( TF ), nutrition education sessions, dietary measures and socio - demographic questionnaires, saturated fat intake ( g ), intake of fruit ( serves ) , vegetables ( serves ) , grain and cereals, total and wholegrain ( serves ), fruit intake, total saturated fat intake, mean vegetable intake
50335_task2
Sentence: Tailored , iterative , printed dietary feedback is as effective as group education in improving dietary behaviours : results from a randomised control trial in middle-aged adults with cardiovascular risk factors . BACKGROUND Tailored nutrition interventions have been shown to be more effective than non-tailored materials in changing dietary behaviours , particularly fat intake and fruit and vegetable intake . But further research examining efficacy of tailored nutrition education in comparison to other nutrition education methods and across a wider range of dietary behaviours is needed . The Stages to Healthy Eating Patterns Study ( STEPs ) was an intervention study , in middle-aged adults with cardiovascular risk factors , to examine the effectiveness of printed , tailored , iterative dietary feedback delivered by mail in improving short-term dietary behaviour in the areas of saturated fat , fruit , vegetable and grain and cereal intake . METHODS STEPs was a 3-month randomised controlled trial with a pre and post-test design . There were three experimental conditions : 1 ) tailored , iterative , printed dietary feedback ( TF ) with three instalments mail-delivered over a 3-month period that were re-tailored to most recent assessment of dietary intake , intention to change and assessment of self-adequacy of dietary intake . Tailoring for dietary intake was performed on data from a validated 63-item combination FFQ designed for the purpose 2 ) small group nutrition education sessions ( GE ) : consisting of two 90-minute dietitian-led small group nutrition education sessions and 3 ) and a wait-listed control ( C ) group who completed the dietary measures and socio-demographic questionnaires at baseline and 3-months later . Dietary outcome measures in the areas of saturated fat intake ( g ) , and the intake of fruit ( serves ) , vegetables ( serves ) , grain and cereals as total and wholegrain ( serves ) were collected using 7-day estimated dietary records . Descriptive statistics , paired t-tests and general linear models adjusted for baseline dietary intake , age and gender were used to examine the effectiveness of different nutrition interventions . RESULTS The TF group reported a significantly greater increase in fruit intake ( 0.3 serves/d P = 0.031 ) in comparison to GE and the C group . All three intervention groups showed a reduction in total saturated fat intake . GE also had a within-group increase in mean vegetable intake after 3 months , but this increase was not different from changes in the other groups . CONCLUSIONS In this study , printed , tailored , iterative dietary feedback was more effective than small group nutrition education in improving the short-term fruit intake behaviour , and as effective in improving saturated fat intake of middle-aged adults with cardiovascular risk factors . This showed that a low-level dietary intervention could achieve modest dietary behaviour changes that are of public health significance . Instructions: please extract entity words from the input sentence
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Tailored , iterative , printed dietary feedback is as effective as group education in improving dietary behaviours : results from a randomised control trial in middle-aged adults with cardiovascular risk factors . BACKGROUND Tailored nutrition interventions have been shown to be more effective than non-tailored materials in changing dietary behaviours , particularly fat intake and fruit and vegetable intake . But further research examining efficacy of tailored nutrition education in comparison to other nutrition education methods and across a wider range of dietary behaviours is needed . The Stages to Healthy Eating Patterns Study ( STEPs ) was an intervention study , in middle-aged adults with cardiovascular risk factors , to examine the effectiveness of printed , tailored , iterative dietary feedback delivered by mail in improving short-term dietary behaviour in the areas of saturated fat , fruit , vegetable and grain and cereal intake . METHODS STEPs was a 3-month randomised controlled trial with a pre and post-test design . There were three experimental conditions : 1 ) tailored , iterative , printed dietary feedback ( TF ) with three instalments mail-delivered over a 3-month period that were re-tailored to most recent assessment of dietary intake , intention to change and assessment of self-adequacy of dietary intake . Tailoring for dietary intake was performed on data from a validated 63-item combination FFQ designed for the purpose 2 ) small group nutrition education sessions ( GE ) : consisting of two 90-minute dietitian-led small group nutrition education sessions and 3 ) and a wait-listed control ( C ) group who completed the dietary measures and socio-demographic questionnaires at baseline and 3-months later . Dietary outcome measures in the areas of saturated fat intake ( g ) , and the intake of fruit ( serves ) , vegetables ( serves ) , grain and cereals as total and wholegrain ( serves ) were collected using 7-day estimated dietary records . Descriptive statistics , paired t-tests and general linear models adjusted for baseline dietary intake , age and gender were used to examine the effectiveness of different nutrition interventions . RESULTS The TF group reported a significantly greater increase in fruit intake ( 0.3 serves/d P = 0.031 ) in comparison to GE and the C group . All three intervention groups showed a reduction in total saturated fat intake . GE also had a within-group increase in mean vegetable intake after 3 months , but this increase was not different from changes in the other groups . CONCLUSIONS In this study , printed , tailored , iterative dietary feedback was more effective than small group nutrition education in improving the short-term fruit intake behaviour , and as effective in improving saturated fat intake of middle-aged adults with cardiovascular risk factors . This showed that a low-level dietary intervention could achieve modest dietary behaviour changes that are of public health significance .
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[ "Outcome_Mental", "Intervention_Educational", "Participant_Condition", "Participant_Age" ]
catheter is an umlsterm, surgical is an umlsterm, myocardium is an umlsterm, thoracotomy is an umlsterm, Cardiopulmonary bypass is an umlsterm, drainage is an umlsterm, femoral vein is an umlsterm, cannulation is an umlsterm, descending aorta is an umlsterm, femoral artery is an umlsterm, internal mammary artery is an umlsterm, grafts is an umlsterm, technique is an umlsterm, descending aorta is an umlsterm, aorta is an umlsterm, administration is an umlsterm, solution is an umlsterm, heart is an umlsterm, catheter is an umlsterm, technique is an umlsterm, catheter is an umlsterm, aortic valve is an umlsterm, ascending aorta is an umlsterm, control is an umlsterm, Cardioplegic solution is an umlsterm, arteries is an umlsterm, aortic valve is an umlsterm, drainage is an umlsterm, technique is an umlsterm, patient is an umlsterm, date is an umlsterm, administration is an umlsterm, solution is an umlsterm
ZfuerHerzThoraxGefaesschirurgie.90130049.eng.abstr_task0
Sentence: In cooperation with Ruesch Inc. , we developed a new catheter for complete surgical revascularisation of myocardium with both arterial and venous bypass grafts using a left lateral thoracotomy . Cardiopulmonary bypass was instituted by drainage of the femoral vein and cannulation of either the descending aorta or the femoral artery . The left internal mammary artery was prepared and connected in the traditional fashion . Peripheral anastomoses of the venous grafts were made in the traditional technique , while the central anastomoses originated from the descending aorta . Occlusion of the aorta by an intraaortic balloon , administration of cardioplegic solution , and decompression of the heart were accomplished with the newly developed catheter technique . The tri-lumen catheter is balloon-tipped and is inserted at the left ventricular apex . Then , the balloon is advanced through the left chamber and the aortic valve to securely occlude the ascending aorta under echocardiographic control . Cardioplegic solution is instilled into the coronary arteries through a second lumen which is directed above the aortic valve . The third lumen opens into the left ventricular cavity and is used as a vent drainage . The new technique was used in one patient to date , and allows for both the administration of cardioplegic solution and complete cardiac decompression . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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In cooperation with Ruesch Inc. , we developed a new catheter for complete surgical revascularisation of myocardium with both arterial and venous bypass grafts using a left lateral thoracotomy . Cardiopulmonary bypass was instituted by drainage of the femoral vein and cannulation of either the descending aorta or the femoral artery . The left internal mammary artery was prepared and connected in the traditional fashion . Peripheral anastomoses of the venous grafts were made in the traditional technique , while the central anastomoses originated from the descending aorta . Occlusion of the aorta by an intraaortic balloon , administration of cardioplegic solution , and decompression of the heart were accomplished with the newly developed catheter technique . The tri-lumen catheter is balloon-tipped and is inserted at the left ventricular apex . Then , the balloon is advanced through the left chamber and the aortic valve to securely occlude the ascending aorta under echocardiographic control . Cardioplegic solution is instilled into the coronary arteries through a second lumen which is directed above the aortic valve . The third lumen opens into the left ventricular cavity and is used as a vent drainage . The new technique was used in one patient to date , and allows for both the administration of cardioplegic solution and complete cardiac decompression .
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[ "umlsterm" ]
catheter is an umlsterm, surgical is an umlsterm, myocardium is an umlsterm, thoracotomy is an umlsterm, Cardiopulmonary bypass is an umlsterm, drainage is an umlsterm, femoral vein is an umlsterm, cannulation is an umlsterm, descending aorta is an umlsterm, femoral artery is an umlsterm, internal mammary artery is an umlsterm, grafts is an umlsterm, technique is an umlsterm, descending aorta is an umlsterm, aorta is an umlsterm, administration is an umlsterm, solution is an umlsterm, heart is an umlsterm, catheter is an umlsterm, technique is an umlsterm, catheter is an umlsterm, aortic valve is an umlsterm, ascending aorta is an umlsterm, control is an umlsterm, Cardioplegic solution is an umlsterm, arteries is an umlsterm, aortic valve is an umlsterm, drainage is an umlsterm, technique is an umlsterm, patient is an umlsterm, date is an umlsterm, administration is an umlsterm, solution is an umlsterm
ZfuerHerzThoraxGefaesschirurgie.90130049.eng.abstr_task1
Sentence: In cooperation with Ruesch Inc. , we developed a new catheter for complete surgical revascularisation of myocardium with both arterial and venous bypass grafts using a left lateral thoracotomy . Cardiopulmonary bypass was instituted by drainage of the femoral vein and cannulation of either the descending aorta or the femoral artery . The left internal mammary artery was prepared and connected in the traditional fashion . Peripheral anastomoses of the venous grafts were made in the traditional technique , while the central anastomoses originated from the descending aorta . Occlusion of the aorta by an intraaortic balloon , administration of cardioplegic solution , and decompression of the heart were accomplished with the newly developed catheter technique . The tri-lumen catheter is balloon-tipped and is inserted at the left ventricular apex . Then , the balloon is advanced through the left chamber and the aortic valve to securely occlude the ascending aorta under echocardiographic control . Cardioplegic solution is instilled into the coronary arteries through a second lumen which is directed above the aortic valve . The third lumen opens into the left ventricular cavity and is used as a vent drainage . The new technique was used in one patient to date , and allows for both the administration of cardioplegic solution and complete cardiac decompression . Instructions: please typing these entity words according to sentence: catheter, surgical, myocardium, thoracotomy, Cardiopulmonary bypass, drainage, femoral vein, cannulation, descending aorta, femoral artery, internal mammary artery, grafts, technique, descending aorta, aorta, administration, solution, heart, catheter, technique, catheter, aortic valve, ascending aorta, control, Cardioplegic solution, arteries, aortic valve, drainage, technique, patient, date, administration, solution Options: umlsterm
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In cooperation with Ruesch Inc. , we developed a new catheter for complete surgical revascularisation of myocardium with both arterial and venous bypass grafts using a left lateral thoracotomy . Cardiopulmonary bypass was instituted by drainage of the femoral vein and cannulation of either the descending aorta or the femoral artery . The left internal mammary artery was prepared and connected in the traditional fashion . Peripheral anastomoses of the venous grafts were made in the traditional technique , while the central anastomoses originated from the descending aorta . Occlusion of the aorta by an intraaortic balloon , administration of cardioplegic solution , and decompression of the heart were accomplished with the newly developed catheter technique . The tri-lumen catheter is balloon-tipped and is inserted at the left ventricular apex . Then , the balloon is advanced through the left chamber and the aortic valve to securely occlude the ascending aorta under echocardiographic control . Cardioplegic solution is instilled into the coronary arteries through a second lumen which is directed above the aortic valve . The third lumen opens into the left ventricular cavity and is used as a vent drainage . The new technique was used in one patient to date , and allows for both the administration of cardioplegic solution and complete cardiac decompression .
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[ "umlsterm" ]
catheter, surgical, myocardium, thoracotomy, Cardiopulmonary bypass, drainage, femoral vein, cannulation, descending aorta, femoral artery, internal mammary artery, grafts, technique, descending aorta, aorta, administration, solution, heart, catheter, technique, catheter, aortic valve, ascending aorta, control, Cardioplegic solution, arteries, aortic valve, drainage, technique, patient, date, administration, solution
ZfuerHerzThoraxGefaesschirurgie.90130049.eng.abstr_task2
Sentence: In cooperation with Ruesch Inc. , we developed a new catheter for complete surgical revascularisation of myocardium with both arterial and venous bypass grafts using a left lateral thoracotomy . Cardiopulmonary bypass was instituted by drainage of the femoral vein and cannulation of either the descending aorta or the femoral artery . The left internal mammary artery was prepared and connected in the traditional fashion . Peripheral anastomoses of the venous grafts were made in the traditional technique , while the central anastomoses originated from the descending aorta . Occlusion of the aorta by an intraaortic balloon , administration of cardioplegic solution , and decompression of the heart were accomplished with the newly developed catheter technique . The tri-lumen catheter is balloon-tipped and is inserted at the left ventricular apex . Then , the balloon is advanced through the left chamber and the aortic valve to securely occlude the ascending aorta under echocardiographic control . Cardioplegic solution is instilled into the coronary arteries through a second lumen which is directed above the aortic valve . The third lumen opens into the left ventricular cavity and is used as a vent drainage . The new technique was used in one patient to date , and allows for both the administration of cardioplegic solution and complete cardiac decompression . Instructions: please extract entity words from the input sentence
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In cooperation with Ruesch Inc. , we developed a new catheter for complete surgical revascularisation of myocardium with both arterial and venous bypass grafts using a left lateral thoracotomy . Cardiopulmonary bypass was instituted by drainage of the femoral vein and cannulation of either the descending aorta or the femoral artery . The left internal mammary artery was prepared and connected in the traditional fashion . Peripheral anastomoses of the venous grafts were made in the traditional technique , while the central anastomoses originated from the descending aorta . Occlusion of the aorta by an intraaortic balloon , administration of cardioplegic solution , and decompression of the heart were accomplished with the newly developed catheter technique . The tri-lumen catheter is balloon-tipped and is inserted at the left ventricular apex . Then , the balloon is advanced through the left chamber and the aortic valve to securely occlude the ascending aorta under echocardiographic control . Cardioplegic solution is instilled into the coronary arteries through a second lumen which is directed above the aortic valve . The third lumen opens into the left ventricular cavity and is used as a vent drainage . The new technique was used in one patient to date , and allows for both the administration of cardioplegic solution and complete cardiac decompression .
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[ "umlsterm" ]
TCL1 oncogene expression is an other_name, AIDS - related lymphomas is a tissue, lymphoid tissues is a tissue
32948_task0
Sentence: TCL1 oncogene expression in AIDS-related lymphomas and lymphoid tissues. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: tissue, other_name
[ "B-other_name", "I-other_name", "I-other_name", "O", "B-tissue", "I-tissue", "I-tissue", "I-tissue", "O", "B-tissue", "I-tissue", "O" ]
TCL1 oncogene expression in AIDS-related lymphomas and lymphoid tissues.
[ "TCL1", "oncogene", "expression", "in", "AIDS", "-", "related", "lymphomas", "and", "lymphoid", "tissues", "." ]
[ "other_name", "DNA_family_or_group", "cell_type", "tissue", "virus", "body_part", "cell_line", "DNA_domain_or_region", "protein_molecule" ]
TCL1 oncogene expression is an other_name, AIDS - related lymphomas is a tissue, lymphoid tissues is a tissue
32948_task1
Sentence: TCL1 oncogene expression in AIDS-related lymphomas and lymphoid tissues. Instructions: please typing these entity words according to sentence: TCL1 oncogene expression, AIDS - related lymphomas, lymphoid tissues Options: tissue, other_name
[ "B-other_name", "I-other_name", "I-other_name", "O", "B-tissue", "I-tissue", "I-tissue", "I-tissue", "O", "B-tissue", "I-tissue", "O" ]
TCL1 oncogene expression in AIDS-related lymphomas and lymphoid tissues.
[ "TCL1", "oncogene", "expression", "in", "AIDS", "-", "related", "lymphomas", "and", "lymphoid", "tissues", "." ]
[ "other_name", "DNA_family_or_group", "cell_type", "tissue", "virus", "body_part", "cell_line", "DNA_domain_or_region", "protein_molecule" ]
TCL1 oncogene expression, AIDS - related lymphomas, lymphoid tissues
32948_task2
Sentence: TCL1 oncogene expression in AIDS-related lymphomas and lymphoid tissues. Instructions: please extract entity words from the input sentence
[ "B-other_name", "I-other_name", "I-other_name", "O", "B-tissue", "I-tissue", "I-tissue", "I-tissue", "O", "B-tissue", "I-tissue", "O" ]
TCL1 oncogene expression in AIDS-related lymphomas and lymphoid tissues.
[ "TCL1", "oncogene", "expression", "in", "AIDS", "-", "related", "lymphomas", "and", "lymphoid", "tissues", "." ]
[ "other_name", "DNA_family_or_group", "cell_type", "tissue", "virus", "body_part", "cell_line", "DNA_domain_or_region", "protein_molecule" ]
Zeit is an umlsterm, Behandlung is an umlsterm, Medikamentes is an umlsterm, Lithium is an umlsterm, Carbamazepin is an umlsterm, Maniebehandlung is an umlsterm, Affektstabilisierung is an umlsterm, Maniebehandlung is an umlsterm, Literatur is an umlsterm, Deutschland is an umlsterm, Patienten is an umlsterm, Patientengruppe is an umlsterm, Pharmakotherapie is an umlsterm
DerNervenarzt.90700662.ger.abstr_task0
Sentence: Trotz der Vielzahl der in juengerer Zeit entdeckten pharmakotherapeutischen Moeglichkeiten gestaltet sich die Behandlung der akuten Manie im Einzelfall oft schwierig . Unabhaengig von der Auswahl des zunaechst eingesetzten Medikamentes , sei es ein Neuroleptikum , Lithium , Carbamazepin oder Valproat , betraegt die Ansprechquote im Schnitt doch nur maximal 50-70% . Oft ist daher die Maniebehandlung durch eine Vielzahl monotherapeutischer und additiver Behandlungsversuche ueber mehrere Monate gekennzeichnet , bis sich eine hinreichende Affektstabilisierung zeigt . Anhand der hier beschriebenen Kasuistik soll daher an die Moeglichkeit der Elektrokonvulsionstherapie ( EKT ) in der Maniebehandlung erinnert werden , die trotz der in der angelsaechsischen Literatur berichteten hohen Erfolgsquote in Deutschland stark in den Hintergrund getreten ist . Wie die Kasuistik aufzeigt , kann sie gerade bei pharmakotherapeutisch nur schwer zu behandelnden und zugleich auch internistisch erkrankten Patienten einen schnellen Heilungserfolg bringen , und sollte daher auch bei dieser Patientengruppe fruehzeitiger erwogen werden . Wie die Kasuistik aber auch zeigt , laesst sich , sofern die Option der Erhaltungs-EKT nicht umsetzbar ist , der Behandlungserfolg in der Regel nur durch eine ueberlappend einsetzende Pharmakotherapie aufrecht erhalten . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]
Trotz der Vielzahl der in juengerer Zeit entdeckten pharmakotherapeutischen Moeglichkeiten gestaltet sich die Behandlung der akuten Manie im Einzelfall oft schwierig . Unabhaengig von der Auswahl des zunaechst eingesetzten Medikamentes , sei es ein Neuroleptikum , Lithium , Carbamazepin oder Valproat , betraegt die Ansprechquote im Schnitt doch nur maximal 50-70% . Oft ist daher die Maniebehandlung durch eine Vielzahl monotherapeutischer und additiver Behandlungsversuche ueber mehrere Monate gekennzeichnet , bis sich eine hinreichende Affektstabilisierung zeigt . Anhand der hier beschriebenen Kasuistik soll daher an die Moeglichkeit der Elektrokonvulsionstherapie ( EKT ) in der Maniebehandlung erinnert werden , die trotz der in der angelsaechsischen Literatur berichteten hohen Erfolgsquote in Deutschland stark in den Hintergrund getreten ist . Wie die Kasuistik aufzeigt , kann sie gerade bei pharmakotherapeutisch nur schwer zu behandelnden und zugleich auch internistisch erkrankten Patienten einen schnellen Heilungserfolg bringen , und sollte daher auch bei dieser Patientengruppe fruehzeitiger erwogen werden . Wie die Kasuistik aber auch zeigt , laesst sich , sofern die Option der Erhaltungs-EKT nicht umsetzbar ist , der Behandlungserfolg in der Regel nur durch eine ueberlappend einsetzende Pharmakotherapie aufrecht erhalten .
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[ "umlsterm" ]
Zeit is an umlsterm, Behandlung is an umlsterm, Medikamentes is an umlsterm, Lithium is an umlsterm, Carbamazepin is an umlsterm, Maniebehandlung is an umlsterm, Affektstabilisierung is an umlsterm, Maniebehandlung is an umlsterm, Literatur is an umlsterm, Deutschland is an umlsterm, Patienten is an umlsterm, Patientengruppe is an umlsterm, Pharmakotherapie is an umlsterm
DerNervenarzt.90700662.ger.abstr_task1
Sentence: Trotz der Vielzahl der in juengerer Zeit entdeckten pharmakotherapeutischen Moeglichkeiten gestaltet sich die Behandlung der akuten Manie im Einzelfall oft schwierig . Unabhaengig von der Auswahl des zunaechst eingesetzten Medikamentes , sei es ein Neuroleptikum , Lithium , Carbamazepin oder Valproat , betraegt die Ansprechquote im Schnitt doch nur maximal 50-70% . Oft ist daher die Maniebehandlung durch eine Vielzahl monotherapeutischer und additiver Behandlungsversuche ueber mehrere Monate gekennzeichnet , bis sich eine hinreichende Affektstabilisierung zeigt . Anhand der hier beschriebenen Kasuistik soll daher an die Moeglichkeit der Elektrokonvulsionstherapie ( EKT ) in der Maniebehandlung erinnert werden , die trotz der in der angelsaechsischen Literatur berichteten hohen Erfolgsquote in Deutschland stark in den Hintergrund getreten ist . Wie die Kasuistik aufzeigt , kann sie gerade bei pharmakotherapeutisch nur schwer zu behandelnden und zugleich auch internistisch erkrankten Patienten einen schnellen Heilungserfolg bringen , und sollte daher auch bei dieser Patientengruppe fruehzeitiger erwogen werden . Wie die Kasuistik aber auch zeigt , laesst sich , sofern die Option der Erhaltungs-EKT nicht umsetzbar ist , der Behandlungserfolg in der Regel nur durch eine ueberlappend einsetzende Pharmakotherapie aufrecht erhalten . Instructions: please typing these entity words according to sentence: Zeit, Behandlung, Medikamentes, Lithium, Carbamazepin, Maniebehandlung, Affektstabilisierung, Maniebehandlung, Literatur, Deutschland, Patienten, Patientengruppe, Pharmakotherapie Options: umlsterm
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Trotz der Vielzahl der in juengerer Zeit entdeckten pharmakotherapeutischen Moeglichkeiten gestaltet sich die Behandlung der akuten Manie im Einzelfall oft schwierig . Unabhaengig von der Auswahl des zunaechst eingesetzten Medikamentes , sei es ein Neuroleptikum , Lithium , Carbamazepin oder Valproat , betraegt die Ansprechquote im Schnitt doch nur maximal 50-70% . Oft ist daher die Maniebehandlung durch eine Vielzahl monotherapeutischer und additiver Behandlungsversuche ueber mehrere Monate gekennzeichnet , bis sich eine hinreichende Affektstabilisierung zeigt . Anhand der hier beschriebenen Kasuistik soll daher an die Moeglichkeit der Elektrokonvulsionstherapie ( EKT ) in der Maniebehandlung erinnert werden , die trotz der in der angelsaechsischen Literatur berichteten hohen Erfolgsquote in Deutschland stark in den Hintergrund getreten ist . Wie die Kasuistik aufzeigt , kann sie gerade bei pharmakotherapeutisch nur schwer zu behandelnden und zugleich auch internistisch erkrankten Patienten einen schnellen Heilungserfolg bringen , und sollte daher auch bei dieser Patientengruppe fruehzeitiger erwogen werden . Wie die Kasuistik aber auch zeigt , laesst sich , sofern die Option der Erhaltungs-EKT nicht umsetzbar ist , der Behandlungserfolg in der Regel nur durch eine ueberlappend einsetzende Pharmakotherapie aufrecht erhalten .
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[ "umlsterm" ]
Zeit, Behandlung, Medikamentes, Lithium, Carbamazepin, Maniebehandlung, Affektstabilisierung, Maniebehandlung, Literatur, Deutschland, Patienten, Patientengruppe, Pharmakotherapie
DerNervenarzt.90700662.ger.abstr_task2
Sentence: Trotz der Vielzahl der in juengerer Zeit entdeckten pharmakotherapeutischen Moeglichkeiten gestaltet sich die Behandlung der akuten Manie im Einzelfall oft schwierig . Unabhaengig von der Auswahl des zunaechst eingesetzten Medikamentes , sei es ein Neuroleptikum , Lithium , Carbamazepin oder Valproat , betraegt die Ansprechquote im Schnitt doch nur maximal 50-70% . Oft ist daher die Maniebehandlung durch eine Vielzahl monotherapeutischer und additiver Behandlungsversuche ueber mehrere Monate gekennzeichnet , bis sich eine hinreichende Affektstabilisierung zeigt . Anhand der hier beschriebenen Kasuistik soll daher an die Moeglichkeit der Elektrokonvulsionstherapie ( EKT ) in der Maniebehandlung erinnert werden , die trotz der in der angelsaechsischen Literatur berichteten hohen Erfolgsquote in Deutschland stark in den Hintergrund getreten ist . Wie die Kasuistik aufzeigt , kann sie gerade bei pharmakotherapeutisch nur schwer zu behandelnden und zugleich auch internistisch erkrankten Patienten einen schnellen Heilungserfolg bringen , und sollte daher auch bei dieser Patientengruppe fruehzeitiger erwogen werden . Wie die Kasuistik aber auch zeigt , laesst sich , sofern die Option der Erhaltungs-EKT nicht umsetzbar ist , der Behandlungserfolg in der Regel nur durch eine ueberlappend einsetzende Pharmakotherapie aufrecht erhalten . Instructions: please extract entity words from the input sentence
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Trotz der Vielzahl der in juengerer Zeit entdeckten pharmakotherapeutischen Moeglichkeiten gestaltet sich die Behandlung der akuten Manie im Einzelfall oft schwierig . Unabhaengig von der Auswahl des zunaechst eingesetzten Medikamentes , sei es ein Neuroleptikum , Lithium , Carbamazepin oder Valproat , betraegt die Ansprechquote im Schnitt doch nur maximal 50-70% . Oft ist daher die Maniebehandlung durch eine Vielzahl monotherapeutischer und additiver Behandlungsversuche ueber mehrere Monate gekennzeichnet , bis sich eine hinreichende Affektstabilisierung zeigt . Anhand der hier beschriebenen Kasuistik soll daher an die Moeglichkeit der Elektrokonvulsionstherapie ( EKT ) in der Maniebehandlung erinnert werden , die trotz der in der angelsaechsischen Literatur berichteten hohen Erfolgsquote in Deutschland stark in den Hintergrund getreten ist . Wie die Kasuistik aufzeigt , kann sie gerade bei pharmakotherapeutisch nur schwer zu behandelnden und zugleich auch internistisch erkrankten Patienten einen schnellen Heilungserfolg bringen , und sollte daher auch bei dieser Patientengruppe fruehzeitiger erwogen werden . Wie die Kasuistik aber auch zeigt , laesst sich , sofern die Option der Erhaltungs-EKT nicht umsetzbar ist , der Behandlungserfolg in der Regel nur durch eine ueberlappend einsetzende Pharmakotherapie aufrecht erhalten .
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[ "umlsterm" ]
Cochlear implantation is an umlsterm, therapy is an umlsterm, treatment is an umlsterm, deafness is an umlsterm, patients is an umlsterm, life is an umlsterm, deafness is an umlsterm, inner ear is an umlsterm, prostheses is an umlsterm, persons is an umlsterm, sound is an umlsterm, therapy is an umlsterm, life is an umlsterm, cultural is an umlsterm, society is an umlsterm, deaf is an umlsterm, community is an umlsterm, rejection is an umlsterm, cochlear implants is an umlsterm, analysis is an umlsterm, deaf is an umlsterm, community is an umlsterm, Knowledge is an umlsterm, cochlear implant is an umlsterm
HNO.80460524.eng.abstr_task0
Sentence: Cochlear implantation has evolved from its experimental state into a safe and effective therapy for the treatment of profound deafness . Although not applicable to all patients , it offers an alternative to a life in silence . In particular , in early detected and treated deafness in childhood inner ear prostheses have enabled affected persons to be integrated into the world of sound . In addition to the significant impact that therapy has on the life of the individual , there is a social and cultural consequence for society . This is epitomized in the criticism by the deaf community that has resulted in the total rejection of cochlear implants . A critical analysis reveals different personal images prevailing in the deaf community . Knowledge of these differences and their relevance is important for all clinicians involved in counselling a cochlear implant candidate . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Cochlear implantation has evolved from its experimental state into a safe and effective therapy for the treatment of profound deafness . Although not applicable to all patients , it offers an alternative to a life in silence . In particular , in early detected and treated deafness in childhood inner ear prostheses have enabled affected persons to be integrated into the world of sound . In addition to the significant impact that therapy has on the life of the individual , there is a social and cultural consequence for society . This is epitomized in the criticism by the deaf community that has resulted in the total rejection of cochlear implants . A critical analysis reveals different personal images prevailing in the deaf community . Knowledge of these differences and their relevance is important for all clinicians involved in counselling a cochlear implant candidate .
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[ "umlsterm" ]
Cochlear implantation is an umlsterm, therapy is an umlsterm, treatment is an umlsterm, deafness is an umlsterm, patients is an umlsterm, life is an umlsterm, deafness is an umlsterm, inner ear is an umlsterm, prostheses is an umlsterm, persons is an umlsterm, sound is an umlsterm, therapy is an umlsterm, life is an umlsterm, cultural is an umlsterm, society is an umlsterm, deaf is an umlsterm, community is an umlsterm, rejection is an umlsterm, cochlear implants is an umlsterm, analysis is an umlsterm, deaf is an umlsterm, community is an umlsterm, Knowledge is an umlsterm, cochlear implant is an umlsterm
HNO.80460524.eng.abstr_task1
Sentence: Cochlear implantation has evolved from its experimental state into a safe and effective therapy for the treatment of profound deafness . Although not applicable to all patients , it offers an alternative to a life in silence . In particular , in early detected and treated deafness in childhood inner ear prostheses have enabled affected persons to be integrated into the world of sound . In addition to the significant impact that therapy has on the life of the individual , there is a social and cultural consequence for society . This is epitomized in the criticism by the deaf community that has resulted in the total rejection of cochlear implants . A critical analysis reveals different personal images prevailing in the deaf community . Knowledge of these differences and their relevance is important for all clinicians involved in counselling a cochlear implant candidate . Instructions: please typing these entity words according to sentence: Cochlear implantation, therapy, treatment, deafness, patients, life, deafness, inner ear, prostheses, persons, sound, therapy, life, cultural, society, deaf, community, rejection, cochlear implants, analysis, deaf, community, Knowledge, cochlear implant Options: umlsterm
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Cochlear implantation has evolved from its experimental state into a safe and effective therapy for the treatment of profound deafness . Although not applicable to all patients , it offers an alternative to a life in silence . In particular , in early detected and treated deafness in childhood inner ear prostheses have enabled affected persons to be integrated into the world of sound . In addition to the significant impact that therapy has on the life of the individual , there is a social and cultural consequence for society . This is epitomized in the criticism by the deaf community that has resulted in the total rejection of cochlear implants . A critical analysis reveals different personal images prevailing in the deaf community . Knowledge of these differences and their relevance is important for all clinicians involved in counselling a cochlear implant candidate .
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[ "umlsterm" ]
Cochlear implantation, therapy, treatment, deafness, patients, life, deafness, inner ear, prostheses, persons, sound, therapy, life, cultural, society, deaf, community, rejection, cochlear implants, analysis, deaf, community, Knowledge, cochlear implant
HNO.80460524.eng.abstr_task2
Sentence: Cochlear implantation has evolved from its experimental state into a safe and effective therapy for the treatment of profound deafness . Although not applicable to all patients , it offers an alternative to a life in silence . In particular , in early detected and treated deafness in childhood inner ear prostheses have enabled affected persons to be integrated into the world of sound . In addition to the significant impact that therapy has on the life of the individual , there is a social and cultural consequence for society . This is epitomized in the criticism by the deaf community that has resulted in the total rejection of cochlear implants . A critical analysis reveals different personal images prevailing in the deaf community . Knowledge of these differences and their relevance is important for all clinicians involved in counselling a cochlear implant candidate . Instructions: please extract entity words from the input sentence
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Cochlear implantation has evolved from its experimental state into a safe and effective therapy for the treatment of profound deafness . Although not applicable to all patients , it offers an alternative to a life in silence . In particular , in early detected and treated deafness in childhood inner ear prostheses have enabled affected persons to be integrated into the world of sound . In addition to the significant impact that therapy has on the life of the individual , there is a social and cultural consequence for society . This is epitomized in the criticism by the deaf community that has resulted in the total rejection of cochlear implants . A critical analysis reveals different personal images prevailing in the deaf community . Knowledge of these differences and their relevance is important for all clinicians involved in counselling a cochlear implant candidate .
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[ "umlsterm" ]
thalidomide is a compound, tumor necrosis factor is a protein, TNF - alpha is a protein
DS.d510_task0
Sentence: The immunomodulatory effects of thalidomide are at least partially mediated through its ability to down-regulate the pathogenic over-production of tumor necrosis factor-alpha (TNF-alpha). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein
[ "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "I-protein", "I-protein", "O", "O", "O", "B-protein", "I-protein", "I-protein", "O", "O" ]
The immunomodulatory effects of thalidomide are at least partially mediated through its ability to down-regulate the pathogenic over-production of tumor necrosis factor-alpha (TNF-alpha).
[ "The", "immunomodulatory", "effects", "of", "thalidomide", "are", "at", "least", "partially", "mediated", "through", "its", "ability", "to", "down", "-", "regulate", "the", "pathogenic", "over", "-", "production", "of", "tumor", "necrosis", "factor", "-", "alpha", "(", "TNF", "-", "alpha", ")", "." ]
[ "protein", "compound" ]
thalidomide is a compound, tumor necrosis factor is a protein, TNF - alpha is a protein
DS.d510_task1
Sentence: The immunomodulatory effects of thalidomide are at least partially mediated through its ability to down-regulate the pathogenic over-production of tumor necrosis factor-alpha (TNF-alpha). Instructions: please typing these entity words according to sentence: thalidomide, tumor necrosis factor, TNF - alpha Options: compound, protein
[ "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "I-protein", "I-protein", "O", "O", "O", "B-protein", "I-protein", "I-protein", "O", "O" ]
The immunomodulatory effects of thalidomide are at least partially mediated through its ability to down-regulate the pathogenic over-production of tumor necrosis factor-alpha (TNF-alpha).
[ "The", "immunomodulatory", "effects", "of", "thalidomide", "are", "at", "least", "partially", "mediated", "through", "its", "ability", "to", "down", "-", "regulate", "the", "pathogenic", "over", "-", "production", "of", "tumor", "necrosis", "factor", "-", "alpha", "(", "TNF", "-", "alpha", ")", "." ]
[ "protein", "compound" ]
thalidomide, tumor necrosis factor, TNF - alpha
DS.d510_task2
Sentence: The immunomodulatory effects of thalidomide are at least partially mediated through its ability to down-regulate the pathogenic over-production of tumor necrosis factor-alpha (TNF-alpha). Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "B-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "I-protein", "I-protein", "O", "O", "O", "B-protein", "I-protein", "I-protein", "O", "O" ]
The immunomodulatory effects of thalidomide are at least partially mediated through its ability to down-regulate the pathogenic over-production of tumor necrosis factor-alpha (TNF-alpha).
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[ "protein", "compound" ]
Asp506Gly is a ProteinMutation
0_task0
Sentence: A novel missense mutation Asp506Gly in Exon 13 of the F11 gene in an asymptomatic Korean woman with mild factor XI deficiency. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: ProteinMutation
[ "O", "O", "O", "O", "B-ProteinMutation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
A novel missense mutation Asp506Gly in Exon 13 of the F11 gene in an asymptomatic Korean woman with mild factor XI deficiency.
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[ "ProteinMutation", "DNAMutation" ]
Asp506Gly is a ProteinMutation
0_task1
Sentence: A novel missense mutation Asp506Gly in Exon 13 of the F11 gene in an asymptomatic Korean woman with mild factor XI deficiency. Instructions: please typing these entity words according to sentence: Asp506Gly Options: ProteinMutation
[ "O", "O", "O", "O", "B-ProteinMutation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
A novel missense mutation Asp506Gly in Exon 13 of the F11 gene in an asymptomatic Korean woman with mild factor XI deficiency.
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[ "ProteinMutation", "DNAMutation" ]
Asp506Gly
0_task2
Sentence: A novel missense mutation Asp506Gly in Exon 13 of the F11 gene in an asymptomatic Korean woman with mild factor XI deficiency. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "B-ProteinMutation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
A novel missense mutation Asp506Gly in Exon 13 of the F11 gene in an asymptomatic Korean woman with mild factor XI deficiency.
[ "A", "novel", "missense", "mutation", "Asp506Gly", "in", "Exon", "13", "of", "the", "F11", "gene", "in", "an", "asymptomatic", "Korean", "woman", "with", "mild", "factor", "XI", "deficiency", "." ]
[ "ProteinMutation", "DNAMutation" ]
Thrombendarteriektomie is an umlsterm, Patienten is an umlsterm, Mortalitaet is an umlsterm, Infarktraten is an umlsterm, Literatur is an umlsterm, Patienten is an umlsterm, Frauen is an umlsterm, Maenner is an umlsterm, Koronararterie is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Stenosen is an umlsterm, Patienten is an umlsterm, Thrombendarteriektomie is an umlsterm, Patienten is an umlsterm
ZfuerHerzThoraxGefaesschirurgie.90130095.ger.abstr_task0
Sentence: Die koronare Thrombendarteriektomie ( TEA ) stellt bei Patienten mit schwerer diffuser Dreigefaesserkrankung zusaetzlich zur aortokoronaren Bypassanlage eine Moeglichkeit der koronaren Revaskularisation dar und wird wegen hoher operativer Mortalitaet und Infarktraten in der Literatur unterschiedlich beurteilt . 86 Patienten ( 19 Frauen und 67 Maenner ) wurden im Rahmen einer koronaren Revaskularisationsoperation thrombendarteriektomiert . 29 TEA des Ramus interventricularis anterior ( RIVA ) und 57 TEA der rechten Koronararterie ( Right coronary artery-RCA ) wurden durchgefuehrt . Die 30-Tage-Mortalitaet war deutlich hoeher als nach koronarer Revaskularisation ohne TEA ( 7% vs. 1,8% ) . Alle thrombendarteriektomierten Patienten ( n=86) wurden nach 18 Monaten kardiologisch untersucht und in ausgewaehlten Faellen kontrollangiographiert . 45 Patienten lebten noch und befanden sich zu 70% im NYHA-Stadium1. Die Patienten nach TEA des RIVA zeigten bis auf eine Ausnahme erneute Stenosen oder Verschluesse ( 70% der Patienten ) . Aus unseren Ergebnissen laesst sich ableiten , dass die koronare Thrombendarteriektomie fuer den Patienten eine erhoehte perioperative Gefaehrdung darstellt , ohne die Durchgaengigkeit des Gefaesses langfristig wiederherzustellen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Die koronare Thrombendarteriektomie ( TEA ) stellt bei Patienten mit schwerer diffuser Dreigefaesserkrankung zusaetzlich zur aortokoronaren Bypassanlage eine Moeglichkeit der koronaren Revaskularisation dar und wird wegen hoher operativer Mortalitaet und Infarktraten in der Literatur unterschiedlich beurteilt . 86 Patienten ( 19 Frauen und 67 Maenner ) wurden im Rahmen einer koronaren Revaskularisationsoperation thrombendarteriektomiert . 29 TEA des Ramus interventricularis anterior ( RIVA ) und 57 TEA der rechten Koronararterie ( Right coronary artery-RCA ) wurden durchgefuehrt . Die 30-Tage-Mortalitaet war deutlich hoeher als nach koronarer Revaskularisation ohne TEA ( 7% vs. 1,8% ) . Alle thrombendarteriektomierten Patienten ( n=86) wurden nach 18 Monaten kardiologisch untersucht und in ausgewaehlten Faellen kontrollangiographiert . 45 Patienten lebten noch und befanden sich zu 70% im NYHA-Stadium1. Die Patienten nach TEA des RIVA zeigten bis auf eine Ausnahme erneute Stenosen oder Verschluesse ( 70% der Patienten ) . Aus unseren Ergebnissen laesst sich ableiten , dass die koronare Thrombendarteriektomie fuer den Patienten eine erhoehte perioperative Gefaehrdung darstellt , ohne die Durchgaengigkeit des Gefaesses langfristig wiederherzustellen .
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[ "umlsterm" ]
Thrombendarteriektomie is an umlsterm, Patienten is an umlsterm, Mortalitaet is an umlsterm, Infarktraten is an umlsterm, Literatur is an umlsterm, Patienten is an umlsterm, Frauen is an umlsterm, Maenner is an umlsterm, Koronararterie is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Stenosen is an umlsterm, Patienten is an umlsterm, Thrombendarteriektomie is an umlsterm, Patienten is an umlsterm
ZfuerHerzThoraxGefaesschirurgie.90130095.ger.abstr_task1
Sentence: Die koronare Thrombendarteriektomie ( TEA ) stellt bei Patienten mit schwerer diffuser Dreigefaesserkrankung zusaetzlich zur aortokoronaren Bypassanlage eine Moeglichkeit der koronaren Revaskularisation dar und wird wegen hoher operativer Mortalitaet und Infarktraten in der Literatur unterschiedlich beurteilt . 86 Patienten ( 19 Frauen und 67 Maenner ) wurden im Rahmen einer koronaren Revaskularisationsoperation thrombendarteriektomiert . 29 TEA des Ramus interventricularis anterior ( RIVA ) und 57 TEA der rechten Koronararterie ( Right coronary artery-RCA ) wurden durchgefuehrt . Die 30-Tage-Mortalitaet war deutlich hoeher als nach koronarer Revaskularisation ohne TEA ( 7% vs. 1,8% ) . Alle thrombendarteriektomierten Patienten ( n=86) wurden nach 18 Monaten kardiologisch untersucht und in ausgewaehlten Faellen kontrollangiographiert . 45 Patienten lebten noch und befanden sich zu 70% im NYHA-Stadium1. Die Patienten nach TEA des RIVA zeigten bis auf eine Ausnahme erneute Stenosen oder Verschluesse ( 70% der Patienten ) . Aus unseren Ergebnissen laesst sich ableiten , dass die koronare Thrombendarteriektomie fuer den Patienten eine erhoehte perioperative Gefaehrdung darstellt , ohne die Durchgaengigkeit des Gefaesses langfristig wiederherzustellen . Instructions: please typing these entity words according to sentence: Thrombendarteriektomie, Patienten, Mortalitaet, Infarktraten, Literatur, Patienten, Frauen, Maenner, Koronararterie, Patienten, Patienten, Patienten, Stenosen, Patienten, Thrombendarteriektomie, Patienten Options: umlsterm
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Die koronare Thrombendarteriektomie ( TEA ) stellt bei Patienten mit schwerer diffuser Dreigefaesserkrankung zusaetzlich zur aortokoronaren Bypassanlage eine Moeglichkeit der koronaren Revaskularisation dar und wird wegen hoher operativer Mortalitaet und Infarktraten in der Literatur unterschiedlich beurteilt . 86 Patienten ( 19 Frauen und 67 Maenner ) wurden im Rahmen einer koronaren Revaskularisationsoperation thrombendarteriektomiert . 29 TEA des Ramus interventricularis anterior ( RIVA ) und 57 TEA der rechten Koronararterie ( Right coronary artery-RCA ) wurden durchgefuehrt . Die 30-Tage-Mortalitaet war deutlich hoeher als nach koronarer Revaskularisation ohne TEA ( 7% vs. 1,8% ) . Alle thrombendarteriektomierten Patienten ( n=86) wurden nach 18 Monaten kardiologisch untersucht und in ausgewaehlten Faellen kontrollangiographiert . 45 Patienten lebten noch und befanden sich zu 70% im NYHA-Stadium1. Die Patienten nach TEA des RIVA zeigten bis auf eine Ausnahme erneute Stenosen oder Verschluesse ( 70% der Patienten ) . Aus unseren Ergebnissen laesst sich ableiten , dass die koronare Thrombendarteriektomie fuer den Patienten eine erhoehte perioperative Gefaehrdung darstellt , ohne die Durchgaengigkeit des Gefaesses langfristig wiederherzustellen .
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[ "umlsterm" ]
Thrombendarteriektomie, Patienten, Mortalitaet, Infarktraten, Literatur, Patienten, Frauen, Maenner, Koronararterie, Patienten, Patienten, Patienten, Stenosen, Patienten, Thrombendarteriektomie, Patienten
ZfuerHerzThoraxGefaesschirurgie.90130095.ger.abstr_task2
Sentence: Die koronare Thrombendarteriektomie ( TEA ) stellt bei Patienten mit schwerer diffuser Dreigefaesserkrankung zusaetzlich zur aortokoronaren Bypassanlage eine Moeglichkeit der koronaren Revaskularisation dar und wird wegen hoher operativer Mortalitaet und Infarktraten in der Literatur unterschiedlich beurteilt . 86 Patienten ( 19 Frauen und 67 Maenner ) wurden im Rahmen einer koronaren Revaskularisationsoperation thrombendarteriektomiert . 29 TEA des Ramus interventricularis anterior ( RIVA ) und 57 TEA der rechten Koronararterie ( Right coronary artery-RCA ) wurden durchgefuehrt . Die 30-Tage-Mortalitaet war deutlich hoeher als nach koronarer Revaskularisation ohne TEA ( 7% vs. 1,8% ) . Alle thrombendarteriektomierten Patienten ( n=86) wurden nach 18 Monaten kardiologisch untersucht und in ausgewaehlten Faellen kontrollangiographiert . 45 Patienten lebten noch und befanden sich zu 70% im NYHA-Stadium1. Die Patienten nach TEA des RIVA zeigten bis auf eine Ausnahme erneute Stenosen oder Verschluesse ( 70% der Patienten ) . Aus unseren Ergebnissen laesst sich ableiten , dass die koronare Thrombendarteriektomie fuer den Patienten eine erhoehte perioperative Gefaehrdung darstellt , ohne die Durchgaengigkeit des Gefaesses langfristig wiederherzustellen . Instructions: please extract entity words from the input sentence
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Die koronare Thrombendarteriektomie ( TEA ) stellt bei Patienten mit schwerer diffuser Dreigefaesserkrankung zusaetzlich zur aortokoronaren Bypassanlage eine Moeglichkeit der koronaren Revaskularisation dar und wird wegen hoher operativer Mortalitaet und Infarktraten in der Literatur unterschiedlich beurteilt . 86 Patienten ( 19 Frauen und 67 Maenner ) wurden im Rahmen einer koronaren Revaskularisationsoperation thrombendarteriektomiert . 29 TEA des Ramus interventricularis anterior ( RIVA ) und 57 TEA der rechten Koronararterie ( Right coronary artery-RCA ) wurden durchgefuehrt . Die 30-Tage-Mortalitaet war deutlich hoeher als nach koronarer Revaskularisation ohne TEA ( 7% vs. 1,8% ) . Alle thrombendarteriektomierten Patienten ( n=86) wurden nach 18 Monaten kardiologisch untersucht und in ausgewaehlten Faellen kontrollangiographiert . 45 Patienten lebten noch und befanden sich zu 70% im NYHA-Stadium1. Die Patienten nach TEA des RIVA zeigten bis auf eine Ausnahme erneute Stenosen oder Verschluesse ( 70% der Patienten ) . Aus unseren Ergebnissen laesst sich ableiten , dass die koronare Thrombendarteriektomie fuer den Patienten eine erhoehte perioperative Gefaehrdung darstellt , ohne die Durchgaengigkeit des Gefaesses langfristig wiederherzustellen .
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[ "umlsterm" ]
Kosteneffizienz is an umlsterm, Gesundheitsausgaben is an umlsterm, Gesundheitswesen is an umlsterm, Wissenschaft is an umlsterm, Wissenschaft is an umlsterm, medizinischen Versorgung is an umlsterm
ZfuerRheumatologie.80570340.ger.abstr_task0
Sentence: Begriffe wie " Kostensenkung " , " Kosteneffizienz Wirtschaftlichkeit " oder " Verbesserung " , " der Ressourcenallokation " sind zentrale Begriffe in der aktuellen gesundheitspolitischen Diskussion . Dagegen wird der Terminus " Rationierung " weitgehend vermieden . Unverkennbar stellt die implizite Rationierung ( z.B. bei der Festlegung von Gesamtbudgets fuer Gesundheitsausgaben oder bei der Festlegung von Niederlassungssperren fuer Fachaerzte ) jedoch eine allgegenwaertige Gestaltungsgeste im deutschen Gesundheitswesen dar . Nur in geringem Masse stuetzen sich Rationierungsentscheidungen bislang auf empirische Grundlagen . Eine wesentliche Aufgabe der Wissenschaft ist die Bereitstellung von Daten zu Kosten und Effekten medizinischer Interventionen im Rahmen soziooekonomischer Untersuchungen . Mit Hilfe entscheidungsanalytischer Verfahren lassen sich diese Daten fuer konkrete Entscheidungsprozesse aufbereiten . Auf Ebene der Wissenschaft ist hierfuer eine Zusammenfuehrung klinischer und oekonomischer Kompetenzen von herausragender Bedeutung . Dagegen sind seitens der Forschungsfoerderer oeffentlich getragene Projekte , die der Komplexitaet soziooekonomischer Fragestellungen in der medizinischen Versorgung Rechnung tragen , dringend erforderlich . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Begriffe wie " Kostensenkung " , " Kosteneffizienz Wirtschaftlichkeit " oder " Verbesserung " , " der Ressourcenallokation " sind zentrale Begriffe in der aktuellen gesundheitspolitischen Diskussion . Dagegen wird der Terminus " Rationierung " weitgehend vermieden . Unverkennbar stellt die implizite Rationierung ( z.B. bei der Festlegung von Gesamtbudgets fuer Gesundheitsausgaben oder bei der Festlegung von Niederlassungssperren fuer Fachaerzte ) jedoch eine allgegenwaertige Gestaltungsgeste im deutschen Gesundheitswesen dar . Nur in geringem Masse stuetzen sich Rationierungsentscheidungen bislang auf empirische Grundlagen . Eine wesentliche Aufgabe der Wissenschaft ist die Bereitstellung von Daten zu Kosten und Effekten medizinischer Interventionen im Rahmen soziooekonomischer Untersuchungen . Mit Hilfe entscheidungsanalytischer Verfahren lassen sich diese Daten fuer konkrete Entscheidungsprozesse aufbereiten . Auf Ebene der Wissenschaft ist hierfuer eine Zusammenfuehrung klinischer und oekonomischer Kompetenzen von herausragender Bedeutung . Dagegen sind seitens der Forschungsfoerderer oeffentlich getragene Projekte , die der Komplexitaet soziooekonomischer Fragestellungen in der medizinischen Versorgung Rechnung tragen , dringend erforderlich .
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[ "umlsterm" ]
Kosteneffizienz is an umlsterm, Gesundheitsausgaben is an umlsterm, Gesundheitswesen is an umlsterm, Wissenschaft is an umlsterm, Wissenschaft is an umlsterm, medizinischen Versorgung is an umlsterm
ZfuerRheumatologie.80570340.ger.abstr_task1
Sentence: Begriffe wie " Kostensenkung " , " Kosteneffizienz Wirtschaftlichkeit " oder " Verbesserung " , " der Ressourcenallokation " sind zentrale Begriffe in der aktuellen gesundheitspolitischen Diskussion . Dagegen wird der Terminus " Rationierung " weitgehend vermieden . Unverkennbar stellt die implizite Rationierung ( z.B. bei der Festlegung von Gesamtbudgets fuer Gesundheitsausgaben oder bei der Festlegung von Niederlassungssperren fuer Fachaerzte ) jedoch eine allgegenwaertige Gestaltungsgeste im deutschen Gesundheitswesen dar . Nur in geringem Masse stuetzen sich Rationierungsentscheidungen bislang auf empirische Grundlagen . Eine wesentliche Aufgabe der Wissenschaft ist die Bereitstellung von Daten zu Kosten und Effekten medizinischer Interventionen im Rahmen soziooekonomischer Untersuchungen . Mit Hilfe entscheidungsanalytischer Verfahren lassen sich diese Daten fuer konkrete Entscheidungsprozesse aufbereiten . Auf Ebene der Wissenschaft ist hierfuer eine Zusammenfuehrung klinischer und oekonomischer Kompetenzen von herausragender Bedeutung . Dagegen sind seitens der Forschungsfoerderer oeffentlich getragene Projekte , die der Komplexitaet soziooekonomischer Fragestellungen in der medizinischen Versorgung Rechnung tragen , dringend erforderlich . Instructions: please typing these entity words according to sentence: Kosteneffizienz, Gesundheitsausgaben, Gesundheitswesen, Wissenschaft, Wissenschaft, medizinischen Versorgung Options: umlsterm
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Begriffe wie " Kostensenkung " , " Kosteneffizienz Wirtschaftlichkeit " oder " Verbesserung " , " der Ressourcenallokation " sind zentrale Begriffe in der aktuellen gesundheitspolitischen Diskussion . Dagegen wird der Terminus " Rationierung " weitgehend vermieden . Unverkennbar stellt die implizite Rationierung ( z.B. bei der Festlegung von Gesamtbudgets fuer Gesundheitsausgaben oder bei der Festlegung von Niederlassungssperren fuer Fachaerzte ) jedoch eine allgegenwaertige Gestaltungsgeste im deutschen Gesundheitswesen dar . Nur in geringem Masse stuetzen sich Rationierungsentscheidungen bislang auf empirische Grundlagen . Eine wesentliche Aufgabe der Wissenschaft ist die Bereitstellung von Daten zu Kosten und Effekten medizinischer Interventionen im Rahmen soziooekonomischer Untersuchungen . Mit Hilfe entscheidungsanalytischer Verfahren lassen sich diese Daten fuer konkrete Entscheidungsprozesse aufbereiten . Auf Ebene der Wissenschaft ist hierfuer eine Zusammenfuehrung klinischer und oekonomischer Kompetenzen von herausragender Bedeutung . Dagegen sind seitens der Forschungsfoerderer oeffentlich getragene Projekte , die der Komplexitaet soziooekonomischer Fragestellungen in der medizinischen Versorgung Rechnung tragen , dringend erforderlich .
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[ "umlsterm" ]
Kosteneffizienz, Gesundheitsausgaben, Gesundheitswesen, Wissenschaft, Wissenschaft, medizinischen Versorgung
ZfuerRheumatologie.80570340.ger.abstr_task2
Sentence: Begriffe wie " Kostensenkung " , " Kosteneffizienz Wirtschaftlichkeit " oder " Verbesserung " , " der Ressourcenallokation " sind zentrale Begriffe in der aktuellen gesundheitspolitischen Diskussion . Dagegen wird der Terminus " Rationierung " weitgehend vermieden . Unverkennbar stellt die implizite Rationierung ( z.B. bei der Festlegung von Gesamtbudgets fuer Gesundheitsausgaben oder bei der Festlegung von Niederlassungssperren fuer Fachaerzte ) jedoch eine allgegenwaertige Gestaltungsgeste im deutschen Gesundheitswesen dar . Nur in geringem Masse stuetzen sich Rationierungsentscheidungen bislang auf empirische Grundlagen . Eine wesentliche Aufgabe der Wissenschaft ist die Bereitstellung von Daten zu Kosten und Effekten medizinischer Interventionen im Rahmen soziooekonomischer Untersuchungen . Mit Hilfe entscheidungsanalytischer Verfahren lassen sich diese Daten fuer konkrete Entscheidungsprozesse aufbereiten . Auf Ebene der Wissenschaft ist hierfuer eine Zusammenfuehrung klinischer und oekonomischer Kompetenzen von herausragender Bedeutung . Dagegen sind seitens der Forschungsfoerderer oeffentlich getragene Projekte , die der Komplexitaet soziooekonomischer Fragestellungen in der medizinischen Versorgung Rechnung tragen , dringend erforderlich . Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O" ]
Begriffe wie " Kostensenkung " , " Kosteneffizienz Wirtschaftlichkeit " oder " Verbesserung " , " der Ressourcenallokation " sind zentrale Begriffe in der aktuellen gesundheitspolitischen Diskussion . Dagegen wird der Terminus " Rationierung " weitgehend vermieden . Unverkennbar stellt die implizite Rationierung ( z.B. bei der Festlegung von Gesamtbudgets fuer Gesundheitsausgaben oder bei der Festlegung von Niederlassungssperren fuer Fachaerzte ) jedoch eine allgegenwaertige Gestaltungsgeste im deutschen Gesundheitswesen dar . Nur in geringem Masse stuetzen sich Rationierungsentscheidungen bislang auf empirische Grundlagen . Eine wesentliche Aufgabe der Wissenschaft ist die Bereitstellung von Daten zu Kosten und Effekten medizinischer Interventionen im Rahmen soziooekonomischer Untersuchungen . Mit Hilfe entscheidungsanalytischer Verfahren lassen sich diese Daten fuer konkrete Entscheidungsprozesse aufbereiten . Auf Ebene der Wissenschaft ist hierfuer eine Zusammenfuehrung klinischer und oekonomischer Kompetenzen von herausragender Bedeutung . Dagegen sind seitens der Forschungsfoerderer oeffentlich getragene Projekte , die der Komplexitaet soziooekonomischer Fragestellungen in der medizinischen Versorgung Rechnung tragen , dringend erforderlich .
[ "Begriffe", "wie", "\"", "Kostensenkung", "\"", ",", "\"", "Kosteneffizienz", "Wirtschaftlichkeit", "\"", "oder", "\"", "Verbesserung", "\"", ",", "\"", "der", "Ressourcenallokation", "\"", "sind", "zentrale", "Begriffe", "in", "der", "aktuellen", "gesundheitspolitischen", "Diskussion", ".", "Dagegen", "wird", "der", "Terminus", "\"", "Rationierung", "\"", "weitgehend", "vermieden", ".", "Unverkennbar", "stellt", "die", "implizite", "Rationierung", "(", "z.", "B.", "bei", "der", "Festlegung", "von", "Gesamtbudgets", "fuer", "Gesundheitsausgaben", "oder", "bei", "der", "Festlegung", "von", "Niederlassungssperren", "fuer", "Fachaerzte", ")", "jedoch", "eine", "allgegenwaertige", "Gestaltungsgeste", "im", "deutschen", "Gesundheitswesen", "dar", ".", "Nur", "in", "geringem", "Masse", "stuetzen", "sich", "Rationierungsentscheidungen", "bislang", "auf", "empirische", "Grundlagen", ".", "Eine", "wesentliche", "Aufgabe", "der", "Wissenschaft", "ist", "die", "Bereitstellung", "von", "Daten", "zu", "Kosten", "und", "Effekten", "medizinischer", "Interventionen", "im", "Rahmen", "soziooekonomischer", "Untersuchungen", ".", "Mit", "Hilfe", "entscheidungsanalytischer", "Verfahren", "lassen", "sich", "diese", "Daten", "fuer", "konkrete", "Entscheidungsprozesse", "aufbereiten", ".", "Auf", "Ebene", "der", "Wissenschaft", "ist", "hierfuer", "eine", "Zusammenfuehrung", "klinischer", "und", "oekonomischer", "Kompetenzen", "von", "herausragender", "Bedeutung", ".", "Dagegen", "sind", "seitens", "der", "Forschungsfoerderer", "oeffentlich", "getragene", "Projekte", ",", "die", "der", "Komplexitaet", "soziooekonomischer", "Fragestellungen", "in", "der", "medizinischen", "Versorgung", "Rechnung", "tragen", ",", "dringend", "erforderlich", "." ]
[ "umlsterm" ]
cellular is a Cell, embryonic is a Developing_anatomical_structure, leukemia is a Cancer, hematopoietic is a Cell, leukemia is a Cancer
PMID-16250015_task0
Sentence: Normal and transforming functions of RUNX1: a perspective. Converging studies from many investigators indicate that RUNX1 has a critical role in the correct maintenance of essential cellular functions during embryonic development and after birth. The discovery that this gene is also frequently mutated in human leukemia has increased the interest in the role that RUNX1 plays in both normal and transforming pathways. Here, we provide an overview of the many roles of RUNX1 in hematopoietic self-renewal and differentiation and summarize the information that is currently available on the many mechanisms of RUNX1 deregulation in human leukemia. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Developing_anatomical_structure, Cancer, Cell
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "O", "O", "B-Developing_anatomical_structure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cancer", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cancer", "O", "O" ]
Normal and transforming functions of RUNX1: a perspective. Converging studies from many investigators indicate that RUNX1 has a critical role in the correct maintenance of essential cellular functions during embryonic development and after birth. The discovery that this gene is also frequently mutated in human leukemia has increased the interest in the role that RUNX1 plays in both normal and transforming pathways. Here, we provide an overview of the many roles of RUNX1 in hematopoietic self-renewal and differentiation and summarize the information that is currently available on the many mechanisms of RUNX1 deregulation in human leukemia.
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[ "Cell", "Developing_anatomical_structure", "Cancer" ]
cellular is a Cell, embryonic is a Developing_anatomical_structure, leukemia is a Cancer, hematopoietic is a Cell, leukemia is a Cancer
PMID-16250015_task1
Sentence: Normal and transforming functions of RUNX1: a perspective. Converging studies from many investigators indicate that RUNX1 has a critical role in the correct maintenance of essential cellular functions during embryonic development and after birth. The discovery that this gene is also frequently mutated in human leukemia has increased the interest in the role that RUNX1 plays in both normal and transforming pathways. Here, we provide an overview of the many roles of RUNX1 in hematopoietic self-renewal and differentiation and summarize the information that is currently available on the many mechanisms of RUNX1 deregulation in human leukemia. Instructions: please typing these entity words according to sentence: cellular, embryonic, leukemia, hematopoietic, leukemia Options: Developing_anatomical_structure, Cancer, Cell
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "O", "O", "B-Developing_anatomical_structure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cancer", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cancer", "O", "O" ]
Normal and transforming functions of RUNX1: a perspective. Converging studies from many investigators indicate that RUNX1 has a critical role in the correct maintenance of essential cellular functions during embryonic development and after birth. The discovery that this gene is also frequently mutated in human leukemia has increased the interest in the role that RUNX1 plays in both normal and transforming pathways. Here, we provide an overview of the many roles of RUNX1 in hematopoietic self-renewal and differentiation and summarize the information that is currently available on the many mechanisms of RUNX1 deregulation in human leukemia.
[ "Normal", "and", "transforming", "functions", "of", "RUNX1", ":", "a", "perspective", ".", "\n", "Converging", "studies", "from", "many", "investigators", "indicate", "that", "RUNX1", "has", "a", "critical", "role", "in", "the", "correct", "maintenance", "of", "essential", "cellular", "functions", "during", "embryonic", "development", "and", "after", "birth", ".", "The", "discovery", "that", "this", "gene", "is", "also", "frequently", "mutated", "in", "human", "leukemia", "has", "increased", "the", "interest", "in", "the", "role", "that", "RUNX1", "plays", "in", "both", "normal", "and", "transforming", "pathways", ".", "Here", ",", "we", "provide", "an", "overview", "of", "the", "many", "roles", "of", "RUNX1", "in", "hematopoietic", "self", "-", "renewal", "and", "differentiation", "and", "summarize", "the", "information", "that", "is", "currently", "available", "on", "the", "many", "mechanisms", "of", "RUNX1", "deregulation", "in", "human", "leukemia", ".", "\n" ]
[ "Cell", "Developing_anatomical_structure", "Cancer" ]
cellular, embryonic, leukemia, hematopoietic, leukemia
PMID-16250015_task2
Sentence: Normal and transforming functions of RUNX1: a perspective. Converging studies from many investigators indicate that RUNX1 has a critical role in the correct maintenance of essential cellular functions during embryonic development and after birth. The discovery that this gene is also frequently mutated in human leukemia has increased the interest in the role that RUNX1 plays in both normal and transforming pathways. Here, we provide an overview of the many roles of RUNX1 in hematopoietic self-renewal and differentiation and summarize the information that is currently available on the many mechanisms of RUNX1 deregulation in human leukemia. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "O", "O", "B-Developing_anatomical_structure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cancer", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cancer", "O", "O" ]
Normal and transforming functions of RUNX1: a perspective. Converging studies from many investigators indicate that RUNX1 has a critical role in the correct maintenance of essential cellular functions during embryonic development and after birth. The discovery that this gene is also frequently mutated in human leukemia has increased the interest in the role that RUNX1 plays in both normal and transforming pathways. Here, we provide an overview of the many roles of RUNX1 in hematopoietic self-renewal and differentiation and summarize the information that is currently available on the many mechanisms of RUNX1 deregulation in human leukemia.
[ "Normal", "and", "transforming", "functions", "of", "RUNX1", ":", "a", "perspective", ".", "\n", "Converging", "studies", "from", "many", "investigators", "indicate", "that", "RUNX1", "has", "a", "critical", "role", "in", "the", "correct", "maintenance", "of", "essential", "cellular", "functions", "during", "embryonic", "development", "and", "after", "birth", ".", "The", "discovery", "that", "this", "gene", "is", "also", "frequently", "mutated", "in", "human", "leukemia", "has", "increased", "the", "interest", "in", "the", "role", "that", "RUNX1", "plays", "in", "both", "normal", "and", "transforming", "pathways", ".", "Here", ",", "we", "provide", "an", "overview", "of", "the", "many", "roles", "of", "RUNX1", "in", "hematopoietic", "self", "-", "renewal", "and", "differentiation", "and", "summarize", "the", "information", "that", "is", "currently", "available", "on", "the", "many", "mechanisms", "of", "RUNX1", "deregulation", "in", "human", "leukemia", ".", "\n" ]
[ "Cell", "Developing_anatomical_structure", "Cancer" ]
cofilin is a Individual_protein, actin - binding protein is a Protein_family_or_group, cofilin is a Individual_protein, actin is a Individual_protein
90_task0
Sentence: Purification of cofilin, a 21,000 molecular weight actin-binding protein, from porcine kidney and identification of the cofilin-binding site in the actin sequence. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Individual_protein, Protein_family_or_group
[ "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "B-Protein_family_or_group", "I-Protein_family_or_group", "I-Protein_family_or_group", "I-Protein_family_or_group", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O" ]
Purification of cofilin, a 21,000 molecular weight actin-binding protein, from porcine kidney and identification of the cofilin-binding site in the actin sequence.
[ "Purification", "of", "cofilin", ",", "a", "21,000", "molecular", "weight", "actin", "-", "binding", "protein", ",", "from", "porcine", "kidney", "and", "identification", "of", "the", "cofilin", "-", "binding", "site", "in", "the", "actin", "sequence", "." ]
[ "Protein_family_or_group", "Individual_protein" ]
cofilin is a Individual_protein, actin - binding protein is a Protein_family_or_group, cofilin is a Individual_protein, actin is a Individual_protein
90_task1
Sentence: Purification of cofilin, a 21,000 molecular weight actin-binding protein, from porcine kidney and identification of the cofilin-binding site in the actin sequence. Instructions: please typing these entity words according to sentence: cofilin, actin - binding protein, cofilin, actin Options: Individual_protein, Protein_family_or_group
[ "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "B-Protein_family_or_group", "I-Protein_family_or_group", "I-Protein_family_or_group", "I-Protein_family_or_group", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O" ]
Purification of cofilin, a 21,000 molecular weight actin-binding protein, from porcine kidney and identification of the cofilin-binding site in the actin sequence.
[ "Purification", "of", "cofilin", ",", "a", "21,000", "molecular", "weight", "actin", "-", "binding", "protein", ",", "from", "porcine", "kidney", "and", "identification", "of", "the", "cofilin", "-", "binding", "site", "in", "the", "actin", "sequence", "." ]
[ "Protein_family_or_group", "Individual_protein" ]
cofilin, actin - binding protein, cofilin, actin
90_task2
Sentence: Purification of cofilin, a 21,000 molecular weight actin-binding protein, from porcine kidney and identification of the cofilin-binding site in the actin sequence. Instructions: please extract entity words from the input sentence
[ "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "B-Protein_family_or_group", "I-Protein_family_or_group", "I-Protein_family_or_group", "I-Protein_family_or_group", "O", "O", "O", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O", "O", "O", "O", "B-Individual_protein", "O", "O" ]
Purification of cofilin, a 21,000 molecular weight actin-binding protein, from porcine kidney and identification of the cofilin-binding site in the actin sequence.
[ "Purification", "of", "cofilin", ",", "a", "21,000", "molecular", "weight", "actin", "-", "binding", "protein", ",", "from", "porcine", "kidney", "and", "identification", "of", "the", "cofilin", "-", "binding", "site", "in", "the", "actin", "sequence", "." ]
[ "Protein_family_or_group", "Individual_protein" ]
adipocytokines is a GENE-N
23497878_task0
Sentence: The influence of Goishi tea on adipocytokines in obese mice. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N
[ "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O" ]
The influence of Goishi tea on adipocytokines in obese mice.
[ "The", "influence", "of", "Goishi", "tea", "on", "adipocytokines", "in", "obese", "mice", "." ]
[ "GENE-Y", "GENE-N", "CHEMICAL" ]
adipocytokines is a GENE-N
23497878_task1
Sentence: The influence of Goishi tea on adipocytokines in obese mice. Instructions: please typing these entity words according to sentence: adipocytokines Options: GENE-N
[ "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O" ]
The influence of Goishi tea on adipocytokines in obese mice.
[ "The", "influence", "of", "Goishi", "tea", "on", "adipocytokines", "in", "obese", "mice", "." ]
[ "GENE-Y", "GENE-N", "CHEMICAL" ]
adipocytokines
23497878_task2
Sentence: The influence of Goishi tea on adipocytokines in obese mice. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "O" ]
The influence of Goishi tea on adipocytokines in obese mice.
[ "The", "influence", "of", "Goishi", "tea", "on", "adipocytokines", "in", "obese", "mice", "." ]
[ "GENE-Y", "GENE-N", "CHEMICAL" ]
sperm is an umlsterm, reproduction is an umlsterm, procedure is an umlsterm, sperm is an umlsterm, aspiration is an umlsterm, sperm is an umlsterm, procedures is an umlsterm, azoospermia is an umlsterm, azoospermia is an umlsterm, techniques is an umlsterm, sperm is an umlsterm, aspiration is an umlsterm, sperm is an umlsterm, northern Europe is an umlsterm, spermatozoa is an umlsterm, injury is an umlsterm, blind is an umlsterm, puncture is an umlsterm
Reproduktionsmedizin.90150435.eng.abstr_task0
Sentence: Nowadays operative sperm retrieval in connection with assisted reproduction is a well-established procedure in urological-gynecological cooperative groups . Microsurgical epididymal sperm aspiration ( MESA ) and testicular sperm extraction ( TESE ) are the fundamental procedures in cases of non-reconstructable obstructive azoospermia or testicular azoospermia . As they are often favored percutaneous techniques such as percutaneous epididymal sperm aspiration ( PESA ) or percutaneous testicular sperm extraction ( PTESE ) , need to be in Anglo-American countries and the countries of northern Europe , discussed regarding their efficacy ( number of retrieved spermatozoa ) and possible testicular injury due to blind or ultrasound-guided puncture . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O" ]
Nowadays operative sperm retrieval in connection with assisted reproduction is a well-established procedure in urological-gynecological cooperative groups . Microsurgical epididymal sperm aspiration ( MESA ) and testicular sperm extraction ( TESE ) are the fundamental procedures in cases of non-reconstructable obstructive azoospermia or testicular azoospermia . As they are often favored percutaneous techniques such as percutaneous epididymal sperm aspiration ( PESA ) or percutaneous testicular sperm extraction ( PTESE ) , need to be in Anglo-American countries and the countries of northern Europe , discussed regarding their efficacy ( number of retrieved spermatozoa ) and possible testicular injury due to blind or ultrasound-guided puncture .
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[ "umlsterm" ]
sperm is an umlsterm, reproduction is an umlsterm, procedure is an umlsterm, sperm is an umlsterm, aspiration is an umlsterm, sperm is an umlsterm, procedures is an umlsterm, azoospermia is an umlsterm, azoospermia is an umlsterm, techniques is an umlsterm, sperm is an umlsterm, aspiration is an umlsterm, sperm is an umlsterm, northern Europe is an umlsterm, spermatozoa is an umlsterm, injury is an umlsterm, blind is an umlsterm, puncture is an umlsterm
Reproduktionsmedizin.90150435.eng.abstr_task1
Sentence: Nowadays operative sperm retrieval in connection with assisted reproduction is a well-established procedure in urological-gynecological cooperative groups . Microsurgical epididymal sperm aspiration ( MESA ) and testicular sperm extraction ( TESE ) are the fundamental procedures in cases of non-reconstructable obstructive azoospermia or testicular azoospermia . As they are often favored percutaneous techniques such as percutaneous epididymal sperm aspiration ( PESA ) or percutaneous testicular sperm extraction ( PTESE ) , need to be in Anglo-American countries and the countries of northern Europe , discussed regarding their efficacy ( number of retrieved spermatozoa ) and possible testicular injury due to blind or ultrasound-guided puncture . Instructions: please typing these entity words according to sentence: sperm, reproduction, procedure, sperm, aspiration, sperm, procedures, azoospermia, azoospermia, techniques, sperm, aspiration, sperm, northern Europe, spermatozoa, injury, blind, puncture Options: umlsterm
[ "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O" ]
Nowadays operative sperm retrieval in connection with assisted reproduction is a well-established procedure in urological-gynecological cooperative groups . Microsurgical epididymal sperm aspiration ( MESA ) and testicular sperm extraction ( TESE ) are the fundamental procedures in cases of non-reconstructable obstructive azoospermia or testicular azoospermia . As they are often favored percutaneous techniques such as percutaneous epididymal sperm aspiration ( PESA ) or percutaneous testicular sperm extraction ( PTESE ) , need to be in Anglo-American countries and the countries of northern Europe , discussed regarding their efficacy ( number of retrieved spermatozoa ) and possible testicular injury due to blind or ultrasound-guided puncture .
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[ "umlsterm" ]
sperm, reproduction, procedure, sperm, aspiration, sperm, procedures, azoospermia, azoospermia, techniques, sperm, aspiration, sperm, northern Europe, spermatozoa, injury, blind, puncture
Reproduktionsmedizin.90150435.eng.abstr_task2
Sentence: Nowadays operative sperm retrieval in connection with assisted reproduction is a well-established procedure in urological-gynecological cooperative groups . Microsurgical epididymal sperm aspiration ( MESA ) and testicular sperm extraction ( TESE ) are the fundamental procedures in cases of non-reconstructable obstructive azoospermia or testicular azoospermia . As they are often favored percutaneous techniques such as percutaneous epididymal sperm aspiration ( PESA ) or percutaneous testicular sperm extraction ( PTESE ) , need to be in Anglo-American countries and the countries of northern Europe , discussed regarding their efficacy ( number of retrieved spermatozoa ) and possible testicular injury due to blind or ultrasound-guided puncture . Instructions: please extract entity words from the input sentence
[ "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O" ]
Nowadays operative sperm retrieval in connection with assisted reproduction is a well-established procedure in urological-gynecological cooperative groups . Microsurgical epididymal sperm aspiration ( MESA ) and testicular sperm extraction ( TESE ) are the fundamental procedures in cases of non-reconstructable obstructive azoospermia or testicular azoospermia . As they are often favored percutaneous techniques such as percutaneous epididymal sperm aspiration ( PESA ) or percutaneous testicular sperm extraction ( PTESE ) , need to be in Anglo-American countries and the countries of northern Europe , discussed regarding their efficacy ( number of retrieved spermatozoa ) and possible testicular injury due to blind or ultrasound-guided puncture .
[ "Nowadays", "operative", "sperm", "retrieval", "in", "connection", "with", "assisted", "reproduction", "is", "a", "well", "-", "established", "procedure", "in", "urological", "-", "gynecological", "cooperative", "groups", ".", "Microsurgical", "epididymal", "sperm", "aspiration", "(", "MESA", ")", "and", "testicular", "sperm", "extraction", "(", "TESE", ")", "are", "the", "fundamental", "procedures", "in", "cases", "of", "non", "-", "reconstructable", "obstructive", "azoospermia", "or", "testicular", "azoospermia", ".", "As", "they", "are", "often", "favored", "percutaneous", "techniques", "such", "as", "percutaneous", "epididymal", "sperm", "aspiration", "(", "PESA", ")", "or", "percutaneous", "testicular", "sperm", "extraction", "(", "PTESE", ")", ",", "need", "to", "be", "in", "Anglo", "-", "American", "countries", "and", "the", "countries", "of", "northern", "Europe", ",", "discussed", "regarding", "their", "efficacy", "(", "number", "of", "retrieved", "spermatozoa", ")", "and", "possible", "testicular", "injury", "due", "to", "blind", "or", "ultrasound", "-", "guided", "puncture", "." ]
[ "umlsterm" ]
chromosomal is a Chromosome, sterol 12alpha - hydroxylase gene is a Gene, CYP8B1 is a Gene, human is a Eukaryote, mouse is a Eukaryote, eukaryotic is a Eukaryote, cytochrome P-450 gene is a Gene, introns is a Intron, Sterol 12alpha - hydroxylase is a Enzyme, CYP8B1 is a Enzyme, hepatic is a Tissue, cytochrome P-450 is a Protein, cholic acid is a OrganicChemical, chenodeoxycholic acid is a OrganicChemical, cholesterol is a Lipid, human is a Eukaryote, mouse is a Eukaryote, CYP8B1 is a Gene, complementary DNA is a DNA, gene is a Gene, genomic DNA is a DNA, introns is a Intron, transcript is a Transcript, human is a Eukaryote, gene is a Gene, promoter is a Promoter, murine is a Eukaryote, gene is a Gene, human is a Eukaryote, CYP8B1 gene is a Gene, chromosome is a Chromosome, murine is a Eukaryote, chromosome is a Chromosome, human is a Eukaryote, chromosome is a Chromosome, chromosome is a Chromosome, gene is a Gene, mouse is a Eukaryote, human is a Eukaryote, CYP8B1 genes is a Gene, TATA box is a TATAbox, promoter is a Promoter, mouse is a Eukaryote, human is a Eukaryote, CYP8B1 is a Gene, mRNA is a MessengerRNA, mice is a Eukaryote, promoter is a Promoter, cis - acting elements is a RegulatoryDNARegion, human is a Eukaryote, promoter is a Promoter, cis - acting regions is a RegulatoryDNARegion, COS cells is a Cell, human is a Eukaryote, coding region is a ProteinCodingRegion, mRNA is a MessengerRNA, enzymatic activity is a CatalyticActivity, 12alpha - hydroxylase is a Enzyme, mammalian is a Eukaryote, cytochrome P-450 gene is a Gene, introns is a Intron, gene is a Gene
45_task0
Sentence: Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns. Sterol 12alpha-hydroxylase (CYP8B1) is a hepatic cytochrome P-450 that controls the ratio of cholic acid over chenodeoxycholic acid in bile and thus controls the solubility of cholesterol. Both the human and the mouse CYP8B1 complementary DNA and gene were cloned and structurally characterized. Surprisingly, the genomic DNA from both species was found to lack introns. The major transcript of the human gene was estimated to be 3950 bp, and the putative promoter region was estimated to be at least 1360 bp. The murine structural gene was found to span approximately 3 kb. By using FISH and radiation hybrid mapping techniques, the human CYP8B1 gene was located to chromosome 3p21.3-p22, whereas FISH mapped the murine counterpart to chromosome 9qF4, a region that is homologous to the third human chromosome. The results from the chromosome mapping and Southern blotting indicated that the gene is present in a single copy. Transcription of the mouse and human CYP8B1 genes was initiated from a position situated 51 and 35 bases, respectively, downstream of a consensus TATA box. A homology of 21% for the promoter regions of mouse and human may indicate differences in transcriptional regulation. Although a potent induction of CYP8B1 mRNA was observed upon starvation of mice, the mechanism behind this effect was not revealed by analysis of the promoter for potential cis-acting elements. In the human promoter, several possible cis-acting regions were identified but none of them could be directly related to bile acid metabolism. After transfection of COS cells with the human coding region, mRNA and enzymatic activity for the 12alpha-hydroxylase were identified. This is the first mammalian cytochrome P-450 gene reported to lack introns. The importance of this structural feature for evolution and gene regulation is discussed. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: ProteinCodingRegion, DNA, Tissue, Cell, CatalyticActivity, Promoter, Enzyme, Chromosome, TATAbox, Gene, Transcript, MessengerRNA, Lipid, RegulatoryDNARegion, Eukaryote, Intron, Protein, OrganicChemical
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Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns. Sterol 12alpha-hydroxylase (CYP8B1) is a hepatic cytochrome P-450 that controls the ratio of cholic acid over chenodeoxycholic acid in bile and thus controls the solubility of cholesterol. Both the human and the mouse CYP8B1 complementary DNA and gene were cloned and structurally characterized. Surprisingly, the genomic DNA from both species was found to lack introns. The major transcript of the human gene was estimated to be 3950 bp, and the putative promoter region was estimated to be at least 1360 bp. The murine structural gene was found to span approximately 3 kb. By using FISH and radiation hybrid mapping techniques, the human CYP8B1 gene was located to chromosome 3p21.3-p22, whereas FISH mapped the murine counterpart to chromosome 9qF4, a region that is homologous to the third human chromosome. The results from the chromosome mapping and Southern blotting indicated that the gene is present in a single copy. Transcription of the mouse and human CYP8B1 genes was initiated from a position situated 51 and 35 bases, respectively, downstream of a consensus TATA box. A homology of 21% for the promoter regions of mouse and human may indicate differences in transcriptional regulation. Although a potent induction of CYP8B1 mRNA was observed upon starvation of mice, the mechanism behind this effect was not revealed by analysis of the promoter for potential cis-acting elements. In the human promoter, several possible cis-acting regions were identified but none of them could be directly related to bile acid metabolism. After transfection of COS cells with the human coding region, mRNA and enzymatic activity for the 12alpha-hydroxylase were identified. This is the first mammalian cytochrome P-450 gene reported to lack introns. The importance of this structural feature for evolution and gene regulation is discussed.
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[ "Gene", "Enzyme", "OrganicChemical", "RegulatoryDNARegion", "CatalyticActivity", "DNA", "Protein", "ProteinCodingRegion", "Chromosome", "Lipid", "Eukaryote", "Transcript", "Cell", "Promoter", "TATAbox", "Intron", "Tissue", "MessengerRNA" ]
chromosomal is a Chromosome, sterol 12alpha - hydroxylase gene is a Gene, CYP8B1 is a Gene, human is a Eukaryote, mouse is a Eukaryote, eukaryotic is a Eukaryote, cytochrome P-450 gene is a Gene, introns is a Intron, Sterol 12alpha - hydroxylase is a Enzyme, CYP8B1 is a Enzyme, hepatic is a Tissue, cytochrome P-450 is a Protein, cholic acid is a OrganicChemical, chenodeoxycholic acid is a OrganicChemical, cholesterol is a Lipid, human is a Eukaryote, mouse is a Eukaryote, CYP8B1 is a Gene, complementary DNA is a DNA, gene is a Gene, genomic DNA is a DNA, introns is a Intron, transcript is a Transcript, human is a Eukaryote, gene is a Gene, promoter is a Promoter, murine is a Eukaryote, gene is a Gene, human is a Eukaryote, CYP8B1 gene is a Gene, chromosome is a Chromosome, murine is a Eukaryote, chromosome is a Chromosome, human is a Eukaryote, chromosome is a Chromosome, chromosome is a Chromosome, gene is a Gene, mouse is a Eukaryote, human is a Eukaryote, CYP8B1 genes is a Gene, TATA box is a TATAbox, promoter is a Promoter, mouse is a Eukaryote, human is a Eukaryote, CYP8B1 is a Gene, mRNA is a MessengerRNA, mice is a Eukaryote, promoter is a Promoter, cis - acting elements is a RegulatoryDNARegion, human is a Eukaryote, promoter is a Promoter, cis - acting regions is a RegulatoryDNARegion, COS cells is a Cell, human is a Eukaryote, coding region is a ProteinCodingRegion, mRNA is a MessengerRNA, enzymatic activity is a CatalyticActivity, 12alpha - hydroxylase is a Enzyme, mammalian is a Eukaryote, cytochrome P-450 gene is a Gene, introns is a Intron, gene is a Gene
45_task1
Sentence: Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns. Sterol 12alpha-hydroxylase (CYP8B1) is a hepatic cytochrome P-450 that controls the ratio of cholic acid over chenodeoxycholic acid in bile and thus controls the solubility of cholesterol. Both the human and the mouse CYP8B1 complementary DNA and gene were cloned and structurally characterized. Surprisingly, the genomic DNA from both species was found to lack introns. The major transcript of the human gene was estimated to be 3950 bp, and the putative promoter region was estimated to be at least 1360 bp. The murine structural gene was found to span approximately 3 kb. By using FISH and radiation hybrid mapping techniques, the human CYP8B1 gene was located to chromosome 3p21.3-p22, whereas FISH mapped the murine counterpart to chromosome 9qF4, a region that is homologous to the third human chromosome. The results from the chromosome mapping and Southern blotting indicated that the gene is present in a single copy. Transcription of the mouse and human CYP8B1 genes was initiated from a position situated 51 and 35 bases, respectively, downstream of a consensus TATA box. A homology of 21% for the promoter regions of mouse and human may indicate differences in transcriptional regulation. Although a potent induction of CYP8B1 mRNA was observed upon starvation of mice, the mechanism behind this effect was not revealed by analysis of the promoter for potential cis-acting elements. In the human promoter, several possible cis-acting regions were identified but none of them could be directly related to bile acid metabolism. After transfection of COS cells with the human coding region, mRNA and enzymatic activity for the 12alpha-hydroxylase were identified. This is the first mammalian cytochrome P-450 gene reported to lack introns. The importance of this structural feature for evolution and gene regulation is discussed. Instructions: please typing these entity words according to sentence: chromosomal, sterol 12alpha - hydroxylase gene, CYP8B1, human, mouse, eukaryotic, cytochrome P-450 gene, introns, Sterol 12alpha - hydroxylase, CYP8B1, hepatic, cytochrome P-450, cholic acid, chenodeoxycholic acid, cholesterol, human, mouse, CYP8B1, complementary DNA, gene, genomic DNA, introns, transcript, human, gene, promoter, murine, gene, human, CYP8B1 gene, chromosome, murine, chromosome, human, chromosome, chromosome, gene, mouse, human, CYP8B1 genes, TATA box, promoter, mouse, human, CYP8B1, mRNA, mice, promoter, cis - acting elements, human, promoter, cis - acting regions, COS cells, human, coding region, mRNA, enzymatic activity, 12alpha - hydroxylase, mammalian, cytochrome P-450 gene, introns, gene Options: ProteinCodingRegion, DNA, Tissue, Cell, CatalyticActivity, Promoter, Enzyme, Chromosome, TATAbox, Gene, Transcript, MessengerRNA, Lipid, RegulatoryDNARegion, Eukaryote, Intron, Protein, OrganicChemical
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Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns. Sterol 12alpha-hydroxylase (CYP8B1) is a hepatic cytochrome P-450 that controls the ratio of cholic acid over chenodeoxycholic acid in bile and thus controls the solubility of cholesterol. Both the human and the mouse CYP8B1 complementary DNA and gene were cloned and structurally characterized. Surprisingly, the genomic DNA from both species was found to lack introns. The major transcript of the human gene was estimated to be 3950 bp, and the putative promoter region was estimated to be at least 1360 bp. The murine structural gene was found to span approximately 3 kb. By using FISH and radiation hybrid mapping techniques, the human CYP8B1 gene was located to chromosome 3p21.3-p22, whereas FISH mapped the murine counterpart to chromosome 9qF4, a region that is homologous to the third human chromosome. The results from the chromosome mapping and Southern blotting indicated that the gene is present in a single copy. Transcription of the mouse and human CYP8B1 genes was initiated from a position situated 51 and 35 bases, respectively, downstream of a consensus TATA box. A homology of 21% for the promoter regions of mouse and human may indicate differences in transcriptional regulation. Although a potent induction of CYP8B1 mRNA was observed upon starvation of mice, the mechanism behind this effect was not revealed by analysis of the promoter for potential cis-acting elements. In the human promoter, several possible cis-acting regions were identified but none of them could be directly related to bile acid metabolism. After transfection of COS cells with the human coding region, mRNA and enzymatic activity for the 12alpha-hydroxylase were identified. This is the first mammalian cytochrome P-450 gene reported to lack introns. The importance of this structural feature for evolution and gene regulation is discussed.
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[ "Gene", "Enzyme", "OrganicChemical", "RegulatoryDNARegion", "CatalyticActivity", "DNA", "Protein", "ProteinCodingRegion", "Chromosome", "Lipid", "Eukaryote", "Transcript", "Cell", "Promoter", "TATAbox", "Intron", "Tissue", "MessengerRNA" ]
chromosomal, sterol 12alpha - hydroxylase gene, CYP8B1, human, mouse, eukaryotic, cytochrome P-450 gene, introns, Sterol 12alpha - hydroxylase, CYP8B1, hepatic, cytochrome P-450, cholic acid, chenodeoxycholic acid, cholesterol, human, mouse, CYP8B1, complementary DNA, gene, genomic DNA, introns, transcript, human, gene, promoter, murine, gene, human, CYP8B1 gene, chromosome, murine, chromosome, human, chromosome, chromosome, gene, mouse, human, CYP8B1 genes, TATA box, promoter, mouse, human, CYP8B1, mRNA, mice, promoter, cis - acting elements, human, promoter, cis - acting regions, COS cells, human, coding region, mRNA, enzymatic activity, 12alpha - hydroxylase, mammalian, cytochrome P-450 gene, introns, gene
45_task2
Sentence: Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns. Sterol 12alpha-hydroxylase (CYP8B1) is a hepatic cytochrome P-450 that controls the ratio of cholic acid over chenodeoxycholic acid in bile and thus controls the solubility of cholesterol. Both the human and the mouse CYP8B1 complementary DNA and gene were cloned and structurally characterized. Surprisingly, the genomic DNA from both species was found to lack introns. The major transcript of the human gene was estimated to be 3950 bp, and the putative promoter region was estimated to be at least 1360 bp. The murine structural gene was found to span approximately 3 kb. By using FISH and radiation hybrid mapping techniques, the human CYP8B1 gene was located to chromosome 3p21.3-p22, whereas FISH mapped the murine counterpart to chromosome 9qF4, a region that is homologous to the third human chromosome. The results from the chromosome mapping and Southern blotting indicated that the gene is present in a single copy. Transcription of the mouse and human CYP8B1 genes was initiated from a position situated 51 and 35 bases, respectively, downstream of a consensus TATA box. A homology of 21% for the promoter regions of mouse and human may indicate differences in transcriptional regulation. Although a potent induction of CYP8B1 mRNA was observed upon starvation of mice, the mechanism behind this effect was not revealed by analysis of the promoter for potential cis-acting elements. In the human promoter, several possible cis-acting regions were identified but none of them could be directly related to bile acid metabolism. After transfection of COS cells with the human coding region, mRNA and enzymatic activity for the 12alpha-hydroxylase were identified. This is the first mammalian cytochrome P-450 gene reported to lack introns. The importance of this structural feature for evolution and gene regulation is discussed. Instructions: please extract entity words from the input sentence
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Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns. Sterol 12alpha-hydroxylase (CYP8B1) is a hepatic cytochrome P-450 that controls the ratio of cholic acid over chenodeoxycholic acid in bile and thus controls the solubility of cholesterol. Both the human and the mouse CYP8B1 complementary DNA and gene were cloned and structurally characterized. Surprisingly, the genomic DNA from both species was found to lack introns. The major transcript of the human gene was estimated to be 3950 bp, and the putative promoter region was estimated to be at least 1360 bp. The murine structural gene was found to span approximately 3 kb. By using FISH and radiation hybrid mapping techniques, the human CYP8B1 gene was located to chromosome 3p21.3-p22, whereas FISH mapped the murine counterpart to chromosome 9qF4, a region that is homologous to the third human chromosome. The results from the chromosome mapping and Southern blotting indicated that the gene is present in a single copy. Transcription of the mouse and human CYP8B1 genes was initiated from a position situated 51 and 35 bases, respectively, downstream of a consensus TATA box. A homology of 21% for the promoter regions of mouse and human may indicate differences in transcriptional regulation. Although a potent induction of CYP8B1 mRNA was observed upon starvation of mice, the mechanism behind this effect was not revealed by analysis of the promoter for potential cis-acting elements. In the human promoter, several possible cis-acting regions were identified but none of them could be directly related to bile acid metabolism. After transfection of COS cells with the human coding region, mRNA and enzymatic activity for the 12alpha-hydroxylase were identified. This is the first mammalian cytochrome P-450 gene reported to lack introns. The importance of this structural feature for evolution and gene regulation is discussed.
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[ "Gene", "Enzyme", "OrganicChemical", "RegulatoryDNARegion", "CatalyticActivity", "DNA", "Protein", "ProteinCodingRegion", "Chromosome", "Lipid", "Eukaryote", "Transcript", "Cell", "Promoter", "TATAbox", "Intron", "Tissue", "MessengerRNA" ]
hydrogenase is a protein, sulfur is a compound
DS.d1_task0
Sentence: The absorption spectrum of the hydrogenase enzyme showed an absorption peak at 425nm indicating that the enzyme had iron-sulfur clusters. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein
[ "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O" ]
The absorption spectrum of the hydrogenase enzyme showed an absorption peak at 425nm indicating that the enzyme had iron-sulfur clusters.
[ "The", "absorption", "spectrum", "of", "the", "hydrogenase", "enzyme", "showed", "an", "absorption", "peak", "at", "425", "nm", "indicating", "that", "the", "enzyme", "had", "iron", "-", "sulfur", "clusters", "." ]
[ "protein", "compound" ]
hydrogenase is a protein, sulfur is a compound
DS.d1_task1
Sentence: The absorption spectrum of the hydrogenase enzyme showed an absorption peak at 425nm indicating that the enzyme had iron-sulfur clusters. Instructions: please typing these entity words according to sentence: hydrogenase, sulfur Options: compound, protein
[ "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O" ]
The absorption spectrum of the hydrogenase enzyme showed an absorption peak at 425nm indicating that the enzyme had iron-sulfur clusters.
[ "The", "absorption", "spectrum", "of", "the", "hydrogenase", "enzyme", "showed", "an", "absorption", "peak", "at", "425", "nm", "indicating", "that", "the", "enzyme", "had", "iron", "-", "sulfur", "clusters", "." ]
[ "protein", "compound" ]
hydrogenase, sulfur
DS.d1_task2
Sentence: The absorption spectrum of the hydrogenase enzyme showed an absorption peak at 425nm indicating that the enzyme had iron-sulfur clusters. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "O", "O" ]
The absorption spectrum of the hydrogenase enzyme showed an absorption peak at 425nm indicating that the enzyme had iron-sulfur clusters.
[ "The", "absorption", "spectrum", "of", "the", "hydrogenase", "enzyme", "showed", "an", "absorption", "peak", "at", "425", "nm", "indicating", "that", "the", "enzyme", "had", "iron", "-", "sulfur", "clusters", "." ]
[ "protein", "compound" ]
Infektion is an umlsterm, Intensivstationen is an umlsterm, Standardhygienemassnahmen is an umlsterm, Personal is an umlsterm, Personalschulungen is an umlsterm, Pneumonierate is an umlsterm
IntensiveMedizin.80350087.ger.abstr_task0
Sentence: Die Beatmungspneumonie ist die wichtigste nosokomiale Infektion auf Intensivstationen . Fuer deren Praevention sind vor allem Standardhygienemassnahmen auf hohem Niveau , qualifiziertes Personal und regelmaessige Personalschulungen wichtig . Weitere Massnahmen , die zu einer Reduktion der Pneumonierate beitragen koennen , sind : ... Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]
Die Beatmungspneumonie ist die wichtigste nosokomiale Infektion auf Intensivstationen . Fuer deren Praevention sind vor allem Standardhygienemassnahmen auf hohem Niveau , qualifiziertes Personal und regelmaessige Personalschulungen wichtig . Weitere Massnahmen , die zu einer Reduktion der Pneumonierate beitragen koennen , sind : ...
[ "Die", "Beatmungspneumonie", "ist", "die", "wichtigste", "nosokomiale", "Infektion", "auf", "Intensivstationen", ".", "Fuer", "deren", "Praevention", "sind", "vor", "allem", "Standardhygienemassnahmen", "auf", "hohem", "Niveau", ",", "qualifiziertes", "Personal", "und", "regelmaessige", "Personalschulungen", "wichtig", ".", "Weitere", "Massnahmen", ",", "die", "zu", "einer", "Reduktion", "der", "Pneumonierate", "beitragen", "koennen", ",", "sind", ":", "..." ]
[ "umlsterm" ]
Infektion is an umlsterm, Intensivstationen is an umlsterm, Standardhygienemassnahmen is an umlsterm, Personal is an umlsterm, Personalschulungen is an umlsterm, Pneumonierate is an umlsterm
IntensiveMedizin.80350087.ger.abstr_task1
Sentence: Die Beatmungspneumonie ist die wichtigste nosokomiale Infektion auf Intensivstationen . Fuer deren Praevention sind vor allem Standardhygienemassnahmen auf hohem Niveau , qualifiziertes Personal und regelmaessige Personalschulungen wichtig . Weitere Massnahmen , die zu einer Reduktion der Pneumonierate beitragen koennen , sind : ... Instructions: please typing these entity words according to sentence: Infektion, Intensivstationen, Standardhygienemassnahmen, Personal, Personalschulungen, Pneumonierate Options: umlsterm
[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]
Die Beatmungspneumonie ist die wichtigste nosokomiale Infektion auf Intensivstationen . Fuer deren Praevention sind vor allem Standardhygienemassnahmen auf hohem Niveau , qualifiziertes Personal und regelmaessige Personalschulungen wichtig . Weitere Massnahmen , die zu einer Reduktion der Pneumonierate beitragen koennen , sind : ...
[ "Die", "Beatmungspneumonie", "ist", "die", "wichtigste", "nosokomiale", "Infektion", "auf", "Intensivstationen", ".", "Fuer", "deren", "Praevention", "sind", "vor", "allem", "Standardhygienemassnahmen", "auf", "hohem", "Niveau", ",", "qualifiziertes", "Personal", "und", "regelmaessige", "Personalschulungen", "wichtig", ".", "Weitere", "Massnahmen", ",", "die", "zu", "einer", "Reduktion", "der", "Pneumonierate", "beitragen", "koennen", ",", "sind", ":", "..." ]
[ "umlsterm" ]
Infektion, Intensivstationen, Standardhygienemassnahmen, Personal, Personalschulungen, Pneumonierate
IntensiveMedizin.80350087.ger.abstr_task2
Sentence: Die Beatmungspneumonie ist die wichtigste nosokomiale Infektion auf Intensivstationen . Fuer deren Praevention sind vor allem Standardhygienemassnahmen auf hohem Niveau , qualifiziertes Personal und regelmaessige Personalschulungen wichtig . Weitere Massnahmen , die zu einer Reduktion der Pneumonierate beitragen koennen , sind : ... Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]
Die Beatmungspneumonie ist die wichtigste nosokomiale Infektion auf Intensivstationen . Fuer deren Praevention sind vor allem Standardhygienemassnahmen auf hohem Niveau , qualifiziertes Personal und regelmaessige Personalschulungen wichtig . Weitere Massnahmen , die zu einer Reduktion der Pneumonierate beitragen koennen , sind : ...
[ "Die", "Beatmungspneumonie", "ist", "die", "wichtigste", "nosokomiale", "Infektion", "auf", "Intensivstationen", ".", "Fuer", "deren", "Praevention", "sind", "vor", "allem", "Standardhygienemassnahmen", "auf", "hohem", "Niveau", ",", "qualifiziertes", "Personal", "und", "regelmaessige", "Personalschulungen", "wichtig", ".", "Weitere", "Massnahmen", ",", "die", "zu", "einer", "Reduktion", "der", "Pneumonierate", "beitragen", "koennen", ",", "sind", ":", "..." ]
[ "umlsterm" ]