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Nitrogen, bisphosphonates, Ras, Bim
23085435_task2
Sentence: Nitrogen-containing bisphosphonates induce apoptosis of hematopoietic tumor cells via inhibition of Ras signaling pathways and Bim-mediated activation of the intrinsic apoptotic pathway. Instructions: please extract entity words from the input sentence
[ "B-CHEMICAL", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Nitrogen-containing bisphosphonates induce apoptosis of hematopoietic tumor cells via inhibition of Ras signaling pathways and Bim-mediated activation of the intrinsic apoptotic pathway.
[ "Nitrogen", "-", "containing", "bisphosphonates", "induce", "apoptosis", "of", "hematopoietic", "tumor", "cells", "via", "inhibition", "of", "Ras", "signaling", "pathways", "and", "Bim", "-", "mediated", "activation", "of", "the", "intrinsic", "apoptotic", "pathway", "." ]
[ "GENE-N", "CHEMICAL", "GENE-Y" ]
Pregnancy is a Condition, Hemodynamic instability is a Condition, Body mass index is a Measurement, greater than 40 kg / m2 is a Value, intravenous is a Qualifier, amiodarone or lidocaine is a Scope, in the last 24 hours is a Temporal, Acute coronary syndrome is a Condition, tachycardia is a Condition, supraventricular RR is a Condition, Contraindications is a Condition, study drugs is a Drug
NCT03299517_exc_task0
Sentence: Pregnancy Hemodynamic instability Body mass index greater than 40 kg / m2 Use of intravenous amiodarone or lidocaine in the last 24 hours Acute coronary syndrome Presence of tachycardia with irregular or supraventricular RR Contraindications to study drugs Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Temporal, Condition, Qualifier, Value, Scope, Measurement, Drug
[ "B-Condition", "O", "B-Condition", "I-Condition", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "O", "O", "B-Qualifier", "B-Scope", "I-Scope", "I-Scope", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Condition", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "O", "B-Drug", "I-Drug", "O" ]
Pregnancy Hemodynamic instability Body mass index greater than 40 kg / m2 Use of intravenous amiodarone or lidocaine in the last 24 hours Acute coronary syndrome Presence of tachycardia with irregular or supraventricular RR Contraindications to study drugs
[ "Pregnancy", "\n", "Hemodynamic", "instability", "\n", "Body", "mass", "index", "greater", "than", "40", "kg", "/", "m2", "\n", "Use", "of", "intravenous", "amiodarone", "or", "lidocaine", "in", "the", "last", "24", "hours", "\n", "Acute", "coronary", "syndrome", "\n", "Presence", "of", "tachycardia", "with", "irregular", "or", "supraventricular", "RR", "\n", "Contraindications", "to", "study", "drugs", "\n" ]
[ "Condition", "Value", "Scope", "Temporal", "Measurement", "Qualifier", "Drug" ]
Pregnancy is a Condition, Hemodynamic instability is a Condition, Body mass index is a Measurement, greater than 40 kg / m2 is a Value, intravenous is a Qualifier, amiodarone or lidocaine is a Scope, in the last 24 hours is a Temporal, Acute coronary syndrome is a Condition, tachycardia is a Condition, supraventricular RR is a Condition, Contraindications is a Condition, study drugs is a Drug
NCT03299517_exc_task1
Sentence: Pregnancy Hemodynamic instability Body mass index greater than 40 kg / m2 Use of intravenous amiodarone or lidocaine in the last 24 hours Acute coronary syndrome Presence of tachycardia with irregular or supraventricular RR Contraindications to study drugs Instructions: please typing these entity words according to sentence: Pregnancy, Hemodynamic instability, Body mass index, greater than 40 kg / m2, intravenous, amiodarone or lidocaine, in the last 24 hours, Acute coronary syndrome, tachycardia, supraventricular RR, Contraindications, study drugs Options: Temporal, Condition, Qualifier, Value, Scope, Measurement, Drug
[ "B-Condition", "O", "B-Condition", "I-Condition", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "O", "O", "B-Qualifier", "B-Scope", "I-Scope", "I-Scope", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Condition", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "O", "B-Drug", "I-Drug", "O" ]
Pregnancy Hemodynamic instability Body mass index greater than 40 kg / m2 Use of intravenous amiodarone or lidocaine in the last 24 hours Acute coronary syndrome Presence of tachycardia with irregular or supraventricular RR Contraindications to study drugs
[ "Pregnancy", "\n", "Hemodynamic", "instability", "\n", "Body", "mass", "index", "greater", "than", "40", "kg", "/", "m2", "\n", "Use", "of", "intravenous", "amiodarone", "or", "lidocaine", "in", "the", "last", "24", "hours", "\n", "Acute", "coronary", "syndrome", "\n", "Presence", "of", "tachycardia", "with", "irregular", "or", "supraventricular", "RR", "\n", "Contraindications", "to", "study", "drugs", "\n" ]
[ "Condition", "Value", "Scope", "Temporal", "Measurement", "Qualifier", "Drug" ]
Pregnancy, Hemodynamic instability, Body mass index, greater than 40 kg / m2, intravenous, amiodarone or lidocaine, in the last 24 hours, Acute coronary syndrome, tachycardia, supraventricular RR, Contraindications, study drugs
NCT03299517_exc_task2
Sentence: Pregnancy Hemodynamic instability Body mass index greater than 40 kg / m2 Use of intravenous amiodarone or lidocaine in the last 24 hours Acute coronary syndrome Presence of tachycardia with irregular or supraventricular RR Contraindications to study drugs Instructions: please extract entity words from the input sentence
[ "B-Condition", "O", "B-Condition", "I-Condition", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "I-Value", "I-Value", "I-Value", "O", "O", "O", "B-Qualifier", "B-Scope", "I-Scope", "I-Scope", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "B-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Condition", "O", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "O", "B-Drug", "I-Drug", "O" ]
Pregnancy Hemodynamic instability Body mass index greater than 40 kg / m2 Use of intravenous amiodarone or lidocaine in the last 24 hours Acute coronary syndrome Presence of tachycardia with irregular or supraventricular RR Contraindications to study drugs
[ "Pregnancy", "\n", "Hemodynamic", "instability", "\n", "Body", "mass", "index", "greater", "than", "40", "kg", "/", "m2", "\n", "Use", "of", "intravenous", "amiodarone", "or", "lidocaine", "in", "the", "last", "24", "hours", "\n", "Acute", "coronary", "syndrome", "\n", "Presence", "of", "tachycardia", "with", "irregular", "or", "supraventricular", "RR", "\n", "Contraindications", "to", "study", "drugs", "\n" ]
[ "Condition", "Value", "Scope", "Temporal", "Measurement", "Qualifier", "Drug" ]
praxisorientierte is an umlsterm, Anatomie is an umlsterm, Weiterbildung is an umlsterm, Wilhelms - Universitaet is an umlsterm, Anatomieausbildung is an umlsterm, Anatomie is an umlsterm, Anatomie is an umlsterm, Anatomie is an umlsterm, Praxisseminare is an umlsterm, Anatomie is an umlsterm
DerChirurg.80691324.ger.abstr_task0
Sentence: Zusammenfassung . Verschiedene Konzepte zur Aenderung der Approbationsordnung zielen auf eine engere Verzahnung zwischen Klinik und Vorklinik ab . Vor diesem Hintergrund ist eine staerker praxisorientierte Anatomie in der aerztlichen Aus- , Fort- und Weiterbildung dringend erforderlich . An der Westfaelischen Wilhelms-Universitaet Muenster wird daher eine interdisziplinaere Anatomieausbildung durchgefuehrt , die von erfahrenen Klinikern in Kooperation mit der Anatomie gestaltet wird . Integrativ ist dabei ein Gesamtkonzept " der Klinischen Anatomie " : Dozenten der Anatomie leiten zusammen mit Klinikern verschiedener Fachrichtungen Praxisseminare begleitend zum Kurs der makroskopischen Anatomie . Klinisch fortgebildete Anatomen bilden in thematischer Anlehnung an Veranstaltungen der klinischen Faecher in praktischen Uebungen an speziellen anatomischen Praeparaten aus . Gemeinsam werden aerztliche Fort- und Weiterbildungsveranstaltungen geplant und durchgefuehrt . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Zusammenfassung . Verschiedene Konzepte zur Aenderung der Approbationsordnung zielen auf eine engere Verzahnung zwischen Klinik und Vorklinik ab . Vor diesem Hintergrund ist eine staerker praxisorientierte Anatomie in der aerztlichen Aus- , Fort- und Weiterbildung dringend erforderlich . An der Westfaelischen Wilhelms-Universitaet Muenster wird daher eine interdisziplinaere Anatomieausbildung durchgefuehrt , die von erfahrenen Klinikern in Kooperation mit der Anatomie gestaltet wird . Integrativ ist dabei ein Gesamtkonzept " der Klinischen Anatomie " : Dozenten der Anatomie leiten zusammen mit Klinikern verschiedener Fachrichtungen Praxisseminare begleitend zum Kurs der makroskopischen Anatomie . Klinisch fortgebildete Anatomen bilden in thematischer Anlehnung an Veranstaltungen der klinischen Faecher in praktischen Uebungen an speziellen anatomischen Praeparaten aus . Gemeinsam werden aerztliche Fort- und Weiterbildungsveranstaltungen geplant und durchgefuehrt .
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[ "umlsterm" ]
praxisorientierte is an umlsterm, Anatomie is an umlsterm, Weiterbildung is an umlsterm, Wilhelms - Universitaet is an umlsterm, Anatomieausbildung is an umlsterm, Anatomie is an umlsterm, Anatomie is an umlsterm, Anatomie is an umlsterm, Praxisseminare is an umlsterm, Anatomie is an umlsterm
DerChirurg.80691324.ger.abstr_task1
Sentence: Zusammenfassung . Verschiedene Konzepte zur Aenderung der Approbationsordnung zielen auf eine engere Verzahnung zwischen Klinik und Vorklinik ab . Vor diesem Hintergrund ist eine staerker praxisorientierte Anatomie in der aerztlichen Aus- , Fort- und Weiterbildung dringend erforderlich . An der Westfaelischen Wilhelms-Universitaet Muenster wird daher eine interdisziplinaere Anatomieausbildung durchgefuehrt , die von erfahrenen Klinikern in Kooperation mit der Anatomie gestaltet wird . Integrativ ist dabei ein Gesamtkonzept " der Klinischen Anatomie " : Dozenten der Anatomie leiten zusammen mit Klinikern verschiedener Fachrichtungen Praxisseminare begleitend zum Kurs der makroskopischen Anatomie . Klinisch fortgebildete Anatomen bilden in thematischer Anlehnung an Veranstaltungen der klinischen Faecher in praktischen Uebungen an speziellen anatomischen Praeparaten aus . Gemeinsam werden aerztliche Fort- und Weiterbildungsveranstaltungen geplant und durchgefuehrt . Instructions: please typing these entity words according to sentence: praxisorientierte, Anatomie, Weiterbildung, Wilhelms - Universitaet, Anatomieausbildung, Anatomie, Anatomie, Anatomie, Praxisseminare, Anatomie Options: umlsterm
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Zusammenfassung . Verschiedene Konzepte zur Aenderung der Approbationsordnung zielen auf eine engere Verzahnung zwischen Klinik und Vorklinik ab . Vor diesem Hintergrund ist eine staerker praxisorientierte Anatomie in der aerztlichen Aus- , Fort- und Weiterbildung dringend erforderlich . An der Westfaelischen Wilhelms-Universitaet Muenster wird daher eine interdisziplinaere Anatomieausbildung durchgefuehrt , die von erfahrenen Klinikern in Kooperation mit der Anatomie gestaltet wird . Integrativ ist dabei ein Gesamtkonzept " der Klinischen Anatomie " : Dozenten der Anatomie leiten zusammen mit Klinikern verschiedener Fachrichtungen Praxisseminare begleitend zum Kurs der makroskopischen Anatomie . Klinisch fortgebildete Anatomen bilden in thematischer Anlehnung an Veranstaltungen der klinischen Faecher in praktischen Uebungen an speziellen anatomischen Praeparaten aus . Gemeinsam werden aerztliche Fort- und Weiterbildungsveranstaltungen geplant und durchgefuehrt .
[ "Zusammenfassung", ".", "Verschiedene", "Konzepte", "zur", "Aenderung", "der", "Approbationsordnung", "zielen", "auf", "eine", "engere", "Verzahnung", "zwischen", "Klinik", "und", "Vorklinik", "ab", ".", "Vor", "diesem", "Hintergrund", "ist", "eine", "staerker", "praxisorientierte", "Anatomie", "in", "der", "aerztlichen", "Aus-", ",", "Fort-", "und", "Weiterbildung", "dringend", "erforderlich", ".", "An", "der", "Westfaelischen", "Wilhelms", "-", "Universitaet", "Muenster", "wird", "daher", "eine", "interdisziplinaere", "Anatomieausbildung", "durchgefuehrt", ",", "die", "von", "erfahrenen", "Klinikern", "in", "Kooperation", "mit", "der", "Anatomie", "gestaltet", "wird", ".", "Integrativ", "ist", "dabei", "ein", "Gesamtkonzept", "\"", "der", "Klinischen", "Anatomie", "\"", ":", "Dozenten", "der", "Anatomie", "leiten", "zusammen", "mit", "Klinikern", "verschiedener", "Fachrichtungen", "Praxisseminare", "begleitend", "zum", "Kurs", "der", "makroskopischen", "Anatomie", ".", "Klinisch", "fortgebildete", "Anatomen", "bilden", "in", "thematischer", "Anlehnung", "an", "Veranstaltungen", "der", "klinischen", "Faecher", "in", "praktischen", "Uebungen", "an", "speziellen", "anatomischen", "Praeparaten", "aus", ".", "Gemeinsam", "werden", "aerztliche", "Fort-", "und", "Weiterbildungsveranstaltungen", "geplant", "und", "durchgefuehrt", "." ]
[ "umlsterm" ]
praxisorientierte, Anatomie, Weiterbildung, Wilhelms - Universitaet, Anatomieausbildung, Anatomie, Anatomie, Anatomie, Praxisseminare, Anatomie
DerChirurg.80691324.ger.abstr_task2
Sentence: Zusammenfassung . Verschiedene Konzepte zur Aenderung der Approbationsordnung zielen auf eine engere Verzahnung zwischen Klinik und Vorklinik ab . Vor diesem Hintergrund ist eine staerker praxisorientierte Anatomie in der aerztlichen Aus- , Fort- und Weiterbildung dringend erforderlich . An der Westfaelischen Wilhelms-Universitaet Muenster wird daher eine interdisziplinaere Anatomieausbildung durchgefuehrt , die von erfahrenen Klinikern in Kooperation mit der Anatomie gestaltet wird . Integrativ ist dabei ein Gesamtkonzept " der Klinischen Anatomie " : Dozenten der Anatomie leiten zusammen mit Klinikern verschiedener Fachrichtungen Praxisseminare begleitend zum Kurs der makroskopischen Anatomie . Klinisch fortgebildete Anatomen bilden in thematischer Anlehnung an Veranstaltungen der klinischen Faecher in praktischen Uebungen an speziellen anatomischen Praeparaten aus . Gemeinsam werden aerztliche Fort- und Weiterbildungsveranstaltungen geplant und durchgefuehrt . Instructions: please extract entity words from the input sentence
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Zusammenfassung . Verschiedene Konzepte zur Aenderung der Approbationsordnung zielen auf eine engere Verzahnung zwischen Klinik und Vorklinik ab . Vor diesem Hintergrund ist eine staerker praxisorientierte Anatomie in der aerztlichen Aus- , Fort- und Weiterbildung dringend erforderlich . An der Westfaelischen Wilhelms-Universitaet Muenster wird daher eine interdisziplinaere Anatomieausbildung durchgefuehrt , die von erfahrenen Klinikern in Kooperation mit der Anatomie gestaltet wird . Integrativ ist dabei ein Gesamtkonzept " der Klinischen Anatomie " : Dozenten der Anatomie leiten zusammen mit Klinikern verschiedener Fachrichtungen Praxisseminare begleitend zum Kurs der makroskopischen Anatomie . Klinisch fortgebildete Anatomen bilden in thematischer Anlehnung an Veranstaltungen der klinischen Faecher in praktischen Uebungen an speziellen anatomischen Praeparaten aus . Gemeinsam werden aerztliche Fort- und Weiterbildungsveranstaltungen geplant und durchgefuehrt .
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[ "umlsterm" ]
Abstract is an umlsterm, non - parasitic is an umlsterm, liver is an umlsterm, cysts is an umlsterm, ultrasound is an umlsterm, CT scan is an umlsterm, patient is an umlsterm, obstructive jaundice is an umlsterm, liver is an umlsterm, cyst is an umlsterm, cyst is an umlsterm, liver is an umlsterm, vessels is an umlsterm, hematoma is an umlsterm, operative therapy is an umlsterm, secondary is an umlsterm, complications is an umlsterm, vein thrombosis is an umlsterm, malignant neoplasm is an umlsterm
DerChirurg.00710963.eng.abstr_task0
Sentence: Abstract . Benign , non-parasitic liver cysts are usually asymptomatic and found incidentally by abdominal ultrasound or CT scan . We present the case of a 68-year-old patient who showed obstructive jaundice due to a hemorrhagic liver cyst compressing the choledochal duct . Due to the location of the cyst in the porta hepatis with partial compression of central liver vessels and the meanwhile organized hematoma , operative therapy was preferred in order to prevent secondary complications such as portal vein thrombosis and to exclude a malignant neoplasm . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]
Abstract . Benign , non-parasitic liver cysts are usually asymptomatic and found incidentally by abdominal ultrasound or CT scan . We present the case of a 68-year-old patient who showed obstructive jaundice due to a hemorrhagic liver cyst compressing the choledochal duct . Due to the location of the cyst in the porta hepatis with partial compression of central liver vessels and the meanwhile organized hematoma , operative therapy was preferred in order to prevent secondary complications such as portal vein thrombosis and to exclude a malignant neoplasm .
[ "Abstract", ".", "Benign", ",", "non", "-", "parasitic", "liver", "cysts", "are", "usually", "asymptomatic", "and", "found", "incidentally", "by", "abdominal", "ultrasound", "or", "CT", "scan", ".", "We", "present", "the", "case", "of", "a", "68-year", "-", "old", "patient", "who", "showed", "obstructive", "jaundice", "due", "to", "a", "hemorrhagic", "liver", "cyst", "compressing", "the", "choledochal", "duct", ".", "Due", "to", "the", "location", "of", "the", "cyst", "in", "the", "porta", "hepatis", "with", "partial", "compression", "of", "central", "liver", "vessels", "and", "the", "meanwhile", "organized", "hematoma", ",", "operative", "therapy", "was", "preferred", "in", "order", "to", "prevent", "secondary", "complications", "such", "as", "portal", "vein", "thrombosis", "and", "to", "exclude", "a", "malignant", "neoplasm", "." ]
[ "umlsterm" ]
Abstract is an umlsterm, non - parasitic is an umlsterm, liver is an umlsterm, cysts is an umlsterm, ultrasound is an umlsterm, CT scan is an umlsterm, patient is an umlsterm, obstructive jaundice is an umlsterm, liver is an umlsterm, cyst is an umlsterm, cyst is an umlsterm, liver is an umlsterm, vessels is an umlsterm, hematoma is an umlsterm, operative therapy is an umlsterm, secondary is an umlsterm, complications is an umlsterm, vein thrombosis is an umlsterm, malignant neoplasm is an umlsterm
DerChirurg.00710963.eng.abstr_task1
Sentence: Abstract . Benign , non-parasitic liver cysts are usually asymptomatic and found incidentally by abdominal ultrasound or CT scan . We present the case of a 68-year-old patient who showed obstructive jaundice due to a hemorrhagic liver cyst compressing the choledochal duct . Due to the location of the cyst in the porta hepatis with partial compression of central liver vessels and the meanwhile organized hematoma , operative therapy was preferred in order to prevent secondary complications such as portal vein thrombosis and to exclude a malignant neoplasm . Instructions: please typing these entity words according to sentence: Abstract, non - parasitic, liver, cysts, ultrasound, CT scan, patient, obstructive jaundice, liver, cyst, cyst, liver, vessels, hematoma, operative therapy, secondary, complications, vein thrombosis, malignant neoplasm Options: umlsterm
[ "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]
Abstract . Benign , non-parasitic liver cysts are usually asymptomatic and found incidentally by abdominal ultrasound or CT scan . We present the case of a 68-year-old patient who showed obstructive jaundice due to a hemorrhagic liver cyst compressing the choledochal duct . Due to the location of the cyst in the porta hepatis with partial compression of central liver vessels and the meanwhile organized hematoma , operative therapy was preferred in order to prevent secondary complications such as portal vein thrombosis and to exclude a malignant neoplasm .
[ "Abstract", ".", "Benign", ",", "non", "-", "parasitic", "liver", "cysts", "are", "usually", "asymptomatic", "and", "found", "incidentally", "by", "abdominal", "ultrasound", "or", "CT", "scan", ".", "We", "present", "the", "case", "of", "a", "68-year", "-", "old", "patient", "who", "showed", "obstructive", "jaundice", "due", "to", "a", "hemorrhagic", "liver", "cyst", "compressing", "the", "choledochal", "duct", ".", "Due", "to", "the", "location", "of", "the", "cyst", "in", "the", "porta", "hepatis", "with", "partial", "compression", "of", "central", "liver", "vessels", "and", "the", "meanwhile", "organized", "hematoma", ",", "operative", "therapy", "was", "preferred", "in", "order", "to", "prevent", "secondary", "complications", "such", "as", "portal", "vein", "thrombosis", "and", "to", "exclude", "a", "malignant", "neoplasm", "." ]
[ "umlsterm" ]
Abstract, non - parasitic, liver, cysts, ultrasound, CT scan, patient, obstructive jaundice, liver, cyst, cyst, liver, vessels, hematoma, operative therapy, secondary, complications, vein thrombosis, malignant neoplasm
DerChirurg.00710963.eng.abstr_task2
Sentence: Abstract . Benign , non-parasitic liver cysts are usually asymptomatic and found incidentally by abdominal ultrasound or CT scan . We present the case of a 68-year-old patient who showed obstructive jaundice due to a hemorrhagic liver cyst compressing the choledochal duct . Due to the location of the cyst in the porta hepatis with partial compression of central liver vessels and the meanwhile organized hematoma , operative therapy was preferred in order to prevent secondary complications such as portal vein thrombosis and to exclude a malignant neoplasm . Instructions: please extract entity words from the input sentence
[ "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]
Abstract . Benign , non-parasitic liver cysts are usually asymptomatic and found incidentally by abdominal ultrasound or CT scan . We present the case of a 68-year-old patient who showed obstructive jaundice due to a hemorrhagic liver cyst compressing the choledochal duct . Due to the location of the cyst in the porta hepatis with partial compression of central liver vessels and the meanwhile organized hematoma , operative therapy was preferred in order to prevent secondary complications such as portal vein thrombosis and to exclude a malignant neoplasm .
[ "Abstract", ".", "Benign", ",", "non", "-", "parasitic", "liver", "cysts", "are", "usually", "asymptomatic", "and", "found", "incidentally", "by", "abdominal", "ultrasound", "or", "CT", "scan", ".", "We", "present", "the", "case", "of", "a", "68-year", "-", "old", "patient", "who", "showed", "obstructive", "jaundice", "due", "to", "a", "hemorrhagic", "liver", "cyst", "compressing", "the", "choledochal", "duct", ".", "Due", "to", "the", "location", "of", "the", "cyst", "in", "the", "porta", "hepatis", "with", "partial", "compression", "of", "central", "liver", "vessels", "and", "the", "meanwhile", "organized", "hematoma", ",", "operative", "therapy", "was", "preferred", "in", "order", "to", "prevent", "secondary", "complications", "such", "as", "portal", "vein", "thrombosis", "and", "to", "exclude", "a", "malignant", "neoplasm", "." ]
[ "umlsterm" ]
Abstract is an umlsterm, defects is an umlsterm, patients is an umlsterm, period is an umlsterm, rectus abdominis muscle is an umlsterm, flap is an umlsterm, defects is an umlsterm, osteomyelitis is an umlsterm, surgery is an umlsterm, therapy is an umlsterm, breast cancer is an umlsterm, flaps is an umlsterm, flaps is an umlsterm, axilla is an umlsterm, flaps is an umlsterm, technique is an umlsterm, time is an umlsterm, flap is an umlsterm, defects is an umlsterm, rehabilitation is an umlsterm, patients is an umlsterm, secondary is an umlsterm, defect is an umlsterm, male is an umlsterm, patients died is an umlsterm
DerChirurg.00711156.eng.abstr_task0
Sentence: Abstract . Longitudinal osteocutaneous defects of the sternal region including the caudal third were reconstructed in 15 patients during a 3-year period by using the " vertical ( VRAM ) - and transverse rectus abdominis muscle " ( TRAM ) flap . The majority of the defects resulted from chronic osteomyelitis after previous cardiothoracic surgery or were due to former therapy of breast cancer . Three VRAM/TRAM flaps were primarily transferred as free flaps with microvascular anastomosis in the axilla region . Nine out of 12 pedicled VRAM or TRAM flaps required an additional microvascular anastomosis because of imminent venous or arterial insufficency ( " supercharging " ) . Therefore , operative technique and operating time of the pedicled and free flap for reconstruction of longitudinal sternal defects are comparable . Adequate reconstruction and rehabilitation was achieved in 11 cases . In 2 patients revision and partial secondary defect coverage was required . Two male patients died postoperatively due to their preexisting condition . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Abstract . Longitudinal osteocutaneous defects of the sternal region including the caudal third were reconstructed in 15 patients during a 3-year period by using the " vertical ( VRAM ) - and transverse rectus abdominis muscle " ( TRAM ) flap . The majority of the defects resulted from chronic osteomyelitis after previous cardiothoracic surgery or were due to former therapy of breast cancer . Three VRAM/TRAM flaps were primarily transferred as free flaps with microvascular anastomosis in the axilla region . Nine out of 12 pedicled VRAM or TRAM flaps required an additional microvascular anastomosis because of imminent venous or arterial insufficency ( " supercharging " ) . Therefore , operative technique and operating time of the pedicled and free flap for reconstruction of longitudinal sternal defects are comparable . Adequate reconstruction and rehabilitation was achieved in 11 cases . In 2 patients revision and partial secondary defect coverage was required . Two male patients died postoperatively due to their preexisting condition .
[ "Abstract", ".", "Longitudinal", "osteocutaneous", "defects", "of", "the", "sternal", "region", "including", "the", "caudal", "third", "were", "reconstructed", "in", "15", "patients", "during", "a", "3-year", "period", "by", "using", "the", "\"", "vertical", "(", "VRAM", ")", "-", "and", "transverse", "rectus", "abdominis", "muscle", "\"", "(", "TRAM", ")", "flap", ".", "The", "majority", "of", "the", "defects", "resulted", "from", "chronic", "osteomyelitis", "after", "previous", "cardiothoracic", "surgery", "or", "were", "due", "to", "former", "therapy", "of", "breast", "cancer", ".", "Three", "VRAM", "/", "TRAM", "flaps", "were", "primarily", "transferred", "as", "free", "flaps", "with", "microvascular", "anastomosis", "in", "the", "axilla", "region", ".", "Nine", "out", "of", "12", "pedicled", "VRAM", "or", "TRAM", "flaps", "required", "an", "additional", "microvascular", "anastomosis", "because", "of", "imminent", "venous", "or", "arterial", "insufficency", "(", "\"", "supercharging", "\"", ")", ".", "Therefore", ",", "operative", "technique", "and", "operating", "time", "of", "the", "pedicled", "and", "free", "flap", "for", "reconstruction", "of", "longitudinal", "sternal", "defects", "are", "comparable", ".", "Adequate", "reconstruction", "and", "rehabilitation", "was", "achieved", "in", "11", "cases", ".", "In", "2", "patients", "revision", "and", "partial", "secondary", "defect", "coverage", "was", "required", ".", "Two", "male", "patients", "died", "postoperatively", "due", "to", "their", "preexisting", "condition", "." ]
[ "umlsterm" ]
Abstract is an umlsterm, defects is an umlsterm, patients is an umlsterm, period is an umlsterm, rectus abdominis muscle is an umlsterm, flap is an umlsterm, defects is an umlsterm, osteomyelitis is an umlsterm, surgery is an umlsterm, therapy is an umlsterm, breast cancer is an umlsterm, flaps is an umlsterm, flaps is an umlsterm, axilla is an umlsterm, flaps is an umlsterm, technique is an umlsterm, time is an umlsterm, flap is an umlsterm, defects is an umlsterm, rehabilitation is an umlsterm, patients is an umlsterm, secondary is an umlsterm, defect is an umlsterm, male is an umlsterm, patients died is an umlsterm
DerChirurg.00711156.eng.abstr_task1
Sentence: Abstract . Longitudinal osteocutaneous defects of the sternal region including the caudal third were reconstructed in 15 patients during a 3-year period by using the " vertical ( VRAM ) - and transverse rectus abdominis muscle " ( TRAM ) flap . The majority of the defects resulted from chronic osteomyelitis after previous cardiothoracic surgery or were due to former therapy of breast cancer . Three VRAM/TRAM flaps were primarily transferred as free flaps with microvascular anastomosis in the axilla region . Nine out of 12 pedicled VRAM or TRAM flaps required an additional microvascular anastomosis because of imminent venous or arterial insufficency ( " supercharging " ) . Therefore , operative technique and operating time of the pedicled and free flap for reconstruction of longitudinal sternal defects are comparable . Adequate reconstruction and rehabilitation was achieved in 11 cases . In 2 patients revision and partial secondary defect coverage was required . Two male patients died postoperatively due to their preexisting condition . Instructions: please typing these entity words according to sentence: Abstract, defects, patients, period, rectus abdominis muscle, flap, defects, osteomyelitis, surgery, therapy, breast cancer, flaps, flaps, axilla, flaps, technique, time, flap, defects, rehabilitation, patients, secondary, defect, male, patients died Options: umlsterm
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Abstract . Longitudinal osteocutaneous defects of the sternal region including the caudal third were reconstructed in 15 patients during a 3-year period by using the " vertical ( VRAM ) - and transverse rectus abdominis muscle " ( TRAM ) flap . The majority of the defects resulted from chronic osteomyelitis after previous cardiothoracic surgery or were due to former therapy of breast cancer . Three VRAM/TRAM flaps were primarily transferred as free flaps with microvascular anastomosis in the axilla region . Nine out of 12 pedicled VRAM or TRAM flaps required an additional microvascular anastomosis because of imminent venous or arterial insufficency ( " supercharging " ) . Therefore , operative technique and operating time of the pedicled and free flap for reconstruction of longitudinal sternal defects are comparable . Adequate reconstruction and rehabilitation was achieved in 11 cases . In 2 patients revision and partial secondary defect coverage was required . Two male patients died postoperatively due to their preexisting condition .
[ "Abstract", ".", "Longitudinal", "osteocutaneous", "defects", "of", "the", "sternal", "region", "including", "the", "caudal", "third", "were", "reconstructed", "in", "15", "patients", "during", "a", "3-year", "period", "by", "using", "the", "\"", "vertical", "(", "VRAM", ")", "-", "and", "transverse", "rectus", "abdominis", "muscle", "\"", "(", "TRAM", ")", "flap", ".", "The", "majority", "of", "the", "defects", "resulted", "from", "chronic", "osteomyelitis", "after", "previous", "cardiothoracic", "surgery", "or", "were", "due", "to", "former", "therapy", "of", "breast", "cancer", ".", "Three", "VRAM", "/", "TRAM", "flaps", "were", "primarily", "transferred", "as", "free", "flaps", "with", "microvascular", "anastomosis", "in", "the", "axilla", "region", ".", "Nine", "out", "of", "12", "pedicled", "VRAM", "or", "TRAM", "flaps", "required", "an", "additional", "microvascular", "anastomosis", "because", "of", "imminent", "venous", "or", "arterial", "insufficency", "(", "\"", "supercharging", "\"", ")", ".", "Therefore", ",", "operative", "technique", "and", "operating", "time", "of", "the", "pedicled", "and", "free", "flap", "for", "reconstruction", "of", "longitudinal", "sternal", "defects", "are", "comparable", ".", "Adequate", "reconstruction", "and", "rehabilitation", "was", "achieved", "in", "11", "cases", ".", "In", "2", "patients", "revision", "and", "partial", "secondary", "defect", "coverage", "was", "required", ".", "Two", "male", "patients", "died", "postoperatively", "due", "to", "their", "preexisting", "condition", "." ]
[ "umlsterm" ]
Abstract, defects, patients, period, rectus abdominis muscle, flap, defects, osteomyelitis, surgery, therapy, breast cancer, flaps, flaps, axilla, flaps, technique, time, flap, defects, rehabilitation, patients, secondary, defect, male, patients died
DerChirurg.00711156.eng.abstr_task2
Sentence: Abstract . Longitudinal osteocutaneous defects of the sternal region including the caudal third were reconstructed in 15 patients during a 3-year period by using the " vertical ( VRAM ) - and transverse rectus abdominis muscle " ( TRAM ) flap . The majority of the defects resulted from chronic osteomyelitis after previous cardiothoracic surgery or were due to former therapy of breast cancer . Three VRAM/TRAM flaps were primarily transferred as free flaps with microvascular anastomosis in the axilla region . Nine out of 12 pedicled VRAM or TRAM flaps required an additional microvascular anastomosis because of imminent venous or arterial insufficency ( " supercharging " ) . Therefore , operative technique and operating time of the pedicled and free flap for reconstruction of longitudinal sternal defects are comparable . Adequate reconstruction and rehabilitation was achieved in 11 cases . In 2 patients revision and partial secondary defect coverage was required . Two male patients died postoperatively due to their preexisting condition . Instructions: please extract entity words from the input sentence
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Abstract . Longitudinal osteocutaneous defects of the sternal region including the caudal third were reconstructed in 15 patients during a 3-year period by using the " vertical ( VRAM ) - and transverse rectus abdominis muscle " ( TRAM ) flap . The majority of the defects resulted from chronic osteomyelitis after previous cardiothoracic surgery or were due to former therapy of breast cancer . Three VRAM/TRAM flaps were primarily transferred as free flaps with microvascular anastomosis in the axilla region . Nine out of 12 pedicled VRAM or TRAM flaps required an additional microvascular anastomosis because of imminent venous or arterial insufficency ( " supercharging " ) . Therefore , operative technique and operating time of the pedicled and free flap for reconstruction of longitudinal sternal defects are comparable . Adequate reconstruction and rehabilitation was achieved in 11 cases . In 2 patients revision and partial secondary defect coverage was required . Two male patients died postoperatively due to their preexisting condition .
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[ "umlsterm" ]
organochlorine is a CHEMICAL, organophosphate is a CHEMICAL, carbamate is a CHEMICAL, pyrethroid is a CHEMICAL, chlorocyclodiene is a CHEMICAL, organophosphates is a CHEMICAL, endosulfan is a CHEMICAL, chlorpyrifos is a CHEMICAL, pyrethroids is a CHEMICAL, carbamate is a CHEMICAL, cypermethrin is a CHEMICAL, deltamethrin is a CHEMICAL, methomyl is a CHEMICAL
27313_task0
Sentence: Resistance to conventional insecticides in Pakistani populations of Musca domestica L. (Diptera: Muscidae): a potential ectoparasite of dairy animals. The house fly, Musca domestica L., is an important hygienic pest of humans and dairy animals with the potential to develop resistance to most chemical classes of insecticides. Six adult house fly strains from dairy farms in Punjab, Pakistan were evaluated for resistance to selected insecticides from organochlorine, organophosphate, carbamate and pyrethroid classes. For a chlorocyclodiene and two organophosphates tested, the resistance ratios (RR) at LC50 were in the range of 5.60-22.02 fold for endosulfan, 7.66-23.24 fold for profenofos and 2.47-7.44 fold for chlorpyrifos. For two pyrethroids and one carbamate, the RR values at LC50 were 30.22-70.02 for cypermethrin, 5.73-18.31 for deltamethrin, and 4.39-15.50 for methomyl. This is the first report of resistance to different classes of insecticides in Pakistani dairy populations of house flies. Regular insecticide resistance monitoring programs on dairy farms are needed to prevent field control failures. Moreover, integrated approaches including the judicious use of insecticides are needed to delay the development of insecticide resistance in house flies. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL
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Resistance to conventional insecticides in Pakistani populations of Musca domestica L. (Diptera: Muscidae): a potential ectoparasite of dairy animals. The house fly, Musca domestica L., is an important hygienic pest of humans and dairy animals with the potential to develop resistance to most chemical classes of insecticides. Six adult house fly strains from dairy farms in Punjab, Pakistan were evaluated for resistance to selected insecticides from organochlorine, organophosphate, carbamate and pyrethroid classes. For a chlorocyclodiene and two organophosphates tested, the resistance ratios (RR) at LC50 were in the range of 5.60-22.02 fold for endosulfan, 7.66-23.24 fold for profenofos and 2.47-7.44 fold for chlorpyrifos. For two pyrethroids and one carbamate, the RR values at LC50 were 30.22-70.02 for cypermethrin, 5.73-18.31 for deltamethrin, and 4.39-15.50 for methomyl. This is the first report of resistance to different classes of insecticides in Pakistani dairy populations of house flies. Regular insecticide resistance monitoring programs on dairy farms are needed to prevent field control failures. Moreover, integrated approaches including the judicious use of insecticides are needed to delay the development of insecticide resistance in house flies.
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[ "CHEMICAL" ]
organochlorine is a CHEMICAL, organophosphate is a CHEMICAL, carbamate is a CHEMICAL, pyrethroid is a CHEMICAL, chlorocyclodiene is a CHEMICAL, organophosphates is a CHEMICAL, endosulfan is a CHEMICAL, chlorpyrifos is a CHEMICAL, pyrethroids is a CHEMICAL, carbamate is a CHEMICAL, cypermethrin is a CHEMICAL, deltamethrin is a CHEMICAL, methomyl is a CHEMICAL
27313_task1
Sentence: Resistance to conventional insecticides in Pakistani populations of Musca domestica L. (Diptera: Muscidae): a potential ectoparasite of dairy animals. The house fly, Musca domestica L., is an important hygienic pest of humans and dairy animals with the potential to develop resistance to most chemical classes of insecticides. Six adult house fly strains from dairy farms in Punjab, Pakistan were evaluated for resistance to selected insecticides from organochlorine, organophosphate, carbamate and pyrethroid classes. For a chlorocyclodiene and two organophosphates tested, the resistance ratios (RR) at LC50 were in the range of 5.60-22.02 fold for endosulfan, 7.66-23.24 fold for profenofos and 2.47-7.44 fold for chlorpyrifos. For two pyrethroids and one carbamate, the RR values at LC50 were 30.22-70.02 for cypermethrin, 5.73-18.31 for deltamethrin, and 4.39-15.50 for methomyl. This is the first report of resistance to different classes of insecticides in Pakistani dairy populations of house flies. Regular insecticide resistance monitoring programs on dairy farms are needed to prevent field control failures. Moreover, integrated approaches including the judicious use of insecticides are needed to delay the development of insecticide resistance in house flies. Instructions: please typing these entity words according to sentence: organochlorine, organophosphate, carbamate, pyrethroid, chlorocyclodiene, organophosphates, endosulfan, chlorpyrifos, pyrethroids, carbamate, cypermethrin, deltamethrin, methomyl Options: CHEMICAL
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Resistance to conventional insecticides in Pakistani populations of Musca domestica L. (Diptera: Muscidae): a potential ectoparasite of dairy animals. The house fly, Musca domestica L., is an important hygienic pest of humans and dairy animals with the potential to develop resistance to most chemical classes of insecticides. Six adult house fly strains from dairy farms in Punjab, Pakistan were evaluated for resistance to selected insecticides from organochlorine, organophosphate, carbamate and pyrethroid classes. For a chlorocyclodiene and two organophosphates tested, the resistance ratios (RR) at LC50 were in the range of 5.60-22.02 fold for endosulfan, 7.66-23.24 fold for profenofos and 2.47-7.44 fold for chlorpyrifos. For two pyrethroids and one carbamate, the RR values at LC50 were 30.22-70.02 for cypermethrin, 5.73-18.31 for deltamethrin, and 4.39-15.50 for methomyl. This is the first report of resistance to different classes of insecticides in Pakistani dairy populations of house flies. Regular insecticide resistance monitoring programs on dairy farms are needed to prevent field control failures. Moreover, integrated approaches including the judicious use of insecticides are needed to delay the development of insecticide resistance in house flies.
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[ "CHEMICAL" ]
organochlorine, organophosphate, carbamate, pyrethroid, chlorocyclodiene, organophosphates, endosulfan, chlorpyrifos, pyrethroids, carbamate, cypermethrin, deltamethrin, methomyl
27313_task2
Sentence: Resistance to conventional insecticides in Pakistani populations of Musca domestica L. (Diptera: Muscidae): a potential ectoparasite of dairy animals. The house fly, Musca domestica L., is an important hygienic pest of humans and dairy animals with the potential to develop resistance to most chemical classes of insecticides. Six adult house fly strains from dairy farms in Punjab, Pakistan were evaluated for resistance to selected insecticides from organochlorine, organophosphate, carbamate and pyrethroid classes. For a chlorocyclodiene and two organophosphates tested, the resistance ratios (RR) at LC50 were in the range of 5.60-22.02 fold for endosulfan, 7.66-23.24 fold for profenofos and 2.47-7.44 fold for chlorpyrifos. For two pyrethroids and one carbamate, the RR values at LC50 were 30.22-70.02 for cypermethrin, 5.73-18.31 for deltamethrin, and 4.39-15.50 for methomyl. This is the first report of resistance to different classes of insecticides in Pakistani dairy populations of house flies. Regular insecticide resistance monitoring programs on dairy farms are needed to prevent field control failures. Moreover, integrated approaches including the judicious use of insecticides are needed to delay the development of insecticide resistance in house flies. Instructions: please extract entity words from the input sentence
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Resistance to conventional insecticides in Pakistani populations of Musca domestica L. (Diptera: Muscidae): a potential ectoparasite of dairy animals. The house fly, Musca domestica L., is an important hygienic pest of humans and dairy animals with the potential to develop resistance to most chemical classes of insecticides. Six adult house fly strains from dairy farms in Punjab, Pakistan were evaluated for resistance to selected insecticides from organochlorine, organophosphate, carbamate and pyrethroid classes. For a chlorocyclodiene and two organophosphates tested, the resistance ratios (RR) at LC50 were in the range of 5.60-22.02 fold for endosulfan, 7.66-23.24 fold for profenofos and 2.47-7.44 fold for chlorpyrifos. For two pyrethroids and one carbamate, the RR values at LC50 were 30.22-70.02 for cypermethrin, 5.73-18.31 for deltamethrin, and 4.39-15.50 for methomyl. This is the first report of resistance to different classes of insecticides in Pakistani dairy populations of house flies. Regular insecticide resistance monitoring programs on dairy farms are needed to prevent field control failures. Moreover, integrated approaches including the judicious use of insecticides are needed to delay the development of insecticide resistance in house flies.
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[ "CHEMICAL" ]
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DerRadiologe.60360199.eng.abstr_task0
Sentence: Purpose : Evaluation of frequency-selective fat saturation ( FS ) and short-tau inversion recovery ( STIR ) fat suppression ( FU ) in MRI of patients with malignant head and neck tumors . Methods : Forty-five patients with biopsy-proven carcinomas of the extracranial head and neck were examined with MRI at 1.0 T. A T 2-weighted TSE sequence with and without STIR-FU and a T 1-weighted SE sequence with and without FS were compared in axial slices . Results : STIR-FU was successful in all and FS in 85-88 % of the head examinations ( nasopharynx , sinuses , oropharynx , and oral cavity ) and 33-46 % of the neck examinations ( hypopharynx and larynx ) . When visualization and delineation of tumors were ranked on a four-point scale ( 0-3 ) , respective mean values for images with/without FU or FS were 2.6/1.9 for T 2-TSE in all examinations , 2.2/1.7 ( nasopharynx and sinuses ) and 1.3/1.4-1.6 ( oropharynx , oral cavity , hypopharynx , and larynx ) for T 1-SE without contrast media administration ( CM ) and 2.3/2.1 ( nasopharynx and sinuses ) and 2.4-2.5/1.9-2.0 ( oropharynx , oral cavity , hypopharynx , and larynx ) with CM . Conclusions : STIR-T 2-TSE was a technically reliable pathfinder for localization and extension of both tumors and lymph nodes . FS-T 1-SE was technically unreliable in examinations of the hypopharynx and larynx . With CM , FS-T 1-SE was most useful for MRI of carcinomas of the oral cavity and oropharynx . In the nasopharynx and sinuses , T 1-SE with CM and FS-T 1-SE with or without CM were equal for tu- mor visualization and delineation . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Purpose : Evaluation of frequency-selective fat saturation ( FS ) and short-tau inversion recovery ( STIR ) fat suppression ( FU ) in MRI of patients with malignant head and neck tumors . Methods : Forty-five patients with biopsy-proven carcinomas of the extracranial head and neck were examined with MRI at 1.0 T. A T 2-weighted TSE sequence with and without STIR-FU and a T 1-weighted SE sequence with and without FS were compared in axial slices . Results : STIR-FU was successful in all and FS in 85-88 % of the head examinations ( nasopharynx , sinuses , oropharynx , and oral cavity ) and 33-46 % of the neck examinations ( hypopharynx and larynx ) . When visualization and delineation of tumors were ranked on a four-point scale ( 0-3 ) , respective mean values for images with/without FU or FS were 2.6/1.9 for T 2-TSE in all examinations , 2.2/1.7 ( nasopharynx and sinuses ) and 1.3/1.4-1.6 ( oropharynx , oral cavity , hypopharynx , and larynx ) for T 1-SE without contrast media administration ( CM ) and 2.3/2.1 ( nasopharynx and sinuses ) and 2.4-2.5/1.9-2.0 ( oropharynx , oral cavity , hypopharynx , and larynx ) with CM . Conclusions : STIR-T 2-TSE was a technically reliable pathfinder for localization and extension of both tumors and lymph nodes . FS-T 1-SE was technically unreliable in examinations of the hypopharynx and larynx . With CM , FS-T 1-SE was most useful for MRI of carcinomas of the oral cavity and oropharynx . In the nasopharynx and sinuses , T 1-SE with CM and FS-T 1-SE with or without CM were equal for tu- mor visualization and delineation .
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[ "umlsterm" ]
Evaluation is an umlsterm, frequency - selective is an umlsterm, fat is an umlsterm, inversion is an umlsterm, fat is an umlsterm, MRI is an umlsterm, patients is an umlsterm, malignant is an umlsterm, head is an umlsterm, neck tumors is an umlsterm, Methods is an umlsterm, patients is an umlsterm, biopsy - proven is an umlsterm, carcinomas is an umlsterm, head is an umlsterm, neck is an umlsterm, MRI is an umlsterm, head is an umlsterm, nasopharynx is an umlsterm, sinuses is an umlsterm, oropharynx is an umlsterm, oral cavity is an umlsterm, neck is an umlsterm, hypopharynx is an umlsterm, larynx is an umlsterm, visualization is an umlsterm, tumors is an umlsterm, scale is an umlsterm, values is an umlsterm, nasopharynx is an umlsterm, sinuses is an umlsterm, oropharynx is an umlsterm, oral cavity is an umlsterm, hypopharynx is an umlsterm, larynx is an umlsterm, contrast media is an umlsterm, administration is an umlsterm, nasopharynx is an umlsterm, sinuses is an umlsterm, oropharynx is an umlsterm, oral cavity is an umlsterm, hypopharynx is an umlsterm, larynx is an umlsterm, tumors is an umlsterm, lymph nodes is an umlsterm, hypopharynx is an umlsterm, larynx is an umlsterm, MRI is an umlsterm, carcinomas is an umlsterm, oral cavity is an umlsterm, oropharynx is an umlsterm, nasopharynx is an umlsterm, sinuses is an umlsterm, visualization is an umlsterm
DerRadiologe.60360199.eng.abstr_task1
Sentence: Purpose : Evaluation of frequency-selective fat saturation ( FS ) and short-tau inversion recovery ( STIR ) fat suppression ( FU ) in MRI of patients with malignant head and neck tumors . Methods : Forty-five patients with biopsy-proven carcinomas of the extracranial head and neck were examined with MRI at 1.0 T. A T 2-weighted TSE sequence with and without STIR-FU and a T 1-weighted SE sequence with and without FS were compared in axial slices . Results : STIR-FU was successful in all and FS in 85-88 % of the head examinations ( nasopharynx , sinuses , oropharynx , and oral cavity ) and 33-46 % of the neck examinations ( hypopharynx and larynx ) . When visualization and delineation of tumors were ranked on a four-point scale ( 0-3 ) , respective mean values for images with/without FU or FS were 2.6/1.9 for T 2-TSE in all examinations , 2.2/1.7 ( nasopharynx and sinuses ) and 1.3/1.4-1.6 ( oropharynx , oral cavity , hypopharynx , and larynx ) for T 1-SE without contrast media administration ( CM ) and 2.3/2.1 ( nasopharynx and sinuses ) and 2.4-2.5/1.9-2.0 ( oropharynx , oral cavity , hypopharynx , and larynx ) with CM . Conclusions : STIR-T 2-TSE was a technically reliable pathfinder for localization and extension of both tumors and lymph nodes . FS-T 1-SE was technically unreliable in examinations of the hypopharynx and larynx . With CM , FS-T 1-SE was most useful for MRI of carcinomas of the oral cavity and oropharynx . In the nasopharynx and sinuses , T 1-SE with CM and FS-T 1-SE with or without CM were equal for tu- mor visualization and delineation . Instructions: please typing these entity words according to sentence: Evaluation, frequency - selective, fat, inversion, fat, MRI, patients, malignant, head, neck tumors, Methods, patients, biopsy - proven, carcinomas, head, neck, MRI, head, nasopharynx, sinuses, oropharynx, oral cavity, neck, hypopharynx, larynx, visualization, tumors, scale, values, nasopharynx, sinuses, oropharynx, oral cavity, hypopharynx, larynx, contrast media, administration, nasopharynx, sinuses, oropharynx, oral cavity, hypopharynx, larynx, tumors, lymph nodes, hypopharynx, larynx, MRI, carcinomas, oral cavity, oropharynx, nasopharynx, sinuses, visualization Options: umlsterm
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Purpose : Evaluation of frequency-selective fat saturation ( FS ) and short-tau inversion recovery ( STIR ) fat suppression ( FU ) in MRI of patients with malignant head and neck tumors . Methods : Forty-five patients with biopsy-proven carcinomas of the extracranial head and neck were examined with MRI at 1.0 T. A T 2-weighted TSE sequence with and without STIR-FU and a T 1-weighted SE sequence with and without FS were compared in axial slices . Results : STIR-FU was successful in all and FS in 85-88 % of the head examinations ( nasopharynx , sinuses , oropharynx , and oral cavity ) and 33-46 % of the neck examinations ( hypopharynx and larynx ) . When visualization and delineation of tumors were ranked on a four-point scale ( 0-3 ) , respective mean values for images with/without FU or FS were 2.6/1.9 for T 2-TSE in all examinations , 2.2/1.7 ( nasopharynx and sinuses ) and 1.3/1.4-1.6 ( oropharynx , oral cavity , hypopharynx , and larynx ) for T 1-SE without contrast media administration ( CM ) and 2.3/2.1 ( nasopharynx and sinuses ) and 2.4-2.5/1.9-2.0 ( oropharynx , oral cavity , hypopharynx , and larynx ) with CM . Conclusions : STIR-T 2-TSE was a technically reliable pathfinder for localization and extension of both tumors and lymph nodes . FS-T 1-SE was technically unreliable in examinations of the hypopharynx and larynx . With CM , FS-T 1-SE was most useful for MRI of carcinomas of the oral cavity and oropharynx . In the nasopharynx and sinuses , T 1-SE with CM and FS-T 1-SE with or without CM were equal for tu- mor visualization and delineation .
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[ "umlsterm" ]
Evaluation, frequency - selective, fat, inversion, fat, MRI, patients, malignant, head, neck tumors, Methods, patients, biopsy - proven, carcinomas, head, neck, MRI, head, nasopharynx, sinuses, oropharynx, oral cavity, neck, hypopharynx, larynx, visualization, tumors, scale, values, nasopharynx, sinuses, oropharynx, oral cavity, hypopharynx, larynx, contrast media, administration, nasopharynx, sinuses, oropharynx, oral cavity, hypopharynx, larynx, tumors, lymph nodes, hypopharynx, larynx, MRI, carcinomas, oral cavity, oropharynx, nasopharynx, sinuses, visualization
DerRadiologe.60360199.eng.abstr_task2
Sentence: Purpose : Evaluation of frequency-selective fat saturation ( FS ) and short-tau inversion recovery ( STIR ) fat suppression ( FU ) in MRI of patients with malignant head and neck tumors . Methods : Forty-five patients with biopsy-proven carcinomas of the extracranial head and neck were examined with MRI at 1.0 T. A T 2-weighted TSE sequence with and without STIR-FU and a T 1-weighted SE sequence with and without FS were compared in axial slices . Results : STIR-FU was successful in all and FS in 85-88 % of the head examinations ( nasopharynx , sinuses , oropharynx , and oral cavity ) and 33-46 % of the neck examinations ( hypopharynx and larynx ) . When visualization and delineation of tumors were ranked on a four-point scale ( 0-3 ) , respective mean values for images with/without FU or FS were 2.6/1.9 for T 2-TSE in all examinations , 2.2/1.7 ( nasopharynx and sinuses ) and 1.3/1.4-1.6 ( oropharynx , oral cavity , hypopharynx , and larynx ) for T 1-SE without contrast media administration ( CM ) and 2.3/2.1 ( nasopharynx and sinuses ) and 2.4-2.5/1.9-2.0 ( oropharynx , oral cavity , hypopharynx , and larynx ) with CM . Conclusions : STIR-T 2-TSE was a technically reliable pathfinder for localization and extension of both tumors and lymph nodes . FS-T 1-SE was technically unreliable in examinations of the hypopharynx and larynx . With CM , FS-T 1-SE was most useful for MRI of carcinomas of the oral cavity and oropharynx . In the nasopharynx and sinuses , T 1-SE with CM and FS-T 1-SE with or without CM were equal for tu- mor visualization and delineation . Instructions: please extract entity words from the input sentence
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Purpose : Evaluation of frequency-selective fat saturation ( FS ) and short-tau inversion recovery ( STIR ) fat suppression ( FU ) in MRI of patients with malignant head and neck tumors . Methods : Forty-five patients with biopsy-proven carcinomas of the extracranial head and neck were examined with MRI at 1.0 T. A T 2-weighted TSE sequence with and without STIR-FU and a T 1-weighted SE sequence with and without FS were compared in axial slices . Results : STIR-FU was successful in all and FS in 85-88 % of the head examinations ( nasopharynx , sinuses , oropharynx , and oral cavity ) and 33-46 % of the neck examinations ( hypopharynx and larynx ) . When visualization and delineation of tumors were ranked on a four-point scale ( 0-3 ) , respective mean values for images with/without FU or FS were 2.6/1.9 for T 2-TSE in all examinations , 2.2/1.7 ( nasopharynx and sinuses ) and 1.3/1.4-1.6 ( oropharynx , oral cavity , hypopharynx , and larynx ) for T 1-SE without contrast media administration ( CM ) and 2.3/2.1 ( nasopharynx and sinuses ) and 2.4-2.5/1.9-2.0 ( oropharynx , oral cavity , hypopharynx , and larynx ) with CM . Conclusions : STIR-T 2-TSE was a technically reliable pathfinder for localization and extension of both tumors and lymph nodes . FS-T 1-SE was technically unreliable in examinations of the hypopharynx and larynx . With CM , FS-T 1-SE was most useful for MRI of carcinomas of the oral cavity and oropharynx . In the nasopharynx and sinuses , T 1-SE with CM and FS-T 1-SE with or without CM were equal for tu- mor visualization and delineation .
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[ "umlsterm" ]
papular urticaria in is a Participant_Condition, children is a Participant_Age, . Papular urticaria is a Participant_Condition, placebo is a Intervention_Control, oral vaccine prepared from insect saliva is a Intervention_Pharmacological, placebo ( stable vaccine solvent ) . is a Intervention_Control, Vaccine is a Intervention_Pharmacological, counting active PU lesions is a Outcome_Physical, serum eosinophils is a Outcome_Physical, IgE is a Outcome_Physical
10006_task0
Sentence: Oral desensitization in papular urticaria in children . Papular urticaria ( PU ) is among the commonest skin ailments in children . Induced specific desensitization to insect bites is theoretically an effective means of prevention of PU . In this double blind placebo controlled study , an oral vaccine prepared from insect saliva was compared with placebo ( stable vaccine solvent ) . Vaccine and placebo effectiveness were tested by counting active PU lesions , serum eosinophils , and IgE , before and after 4 months of treatment . Statistically significant differences between oral vaccine and placebo were not found in the clinical or the immunological variables tested . We conclude that , although a lack of oral vaccine efficacy was suspected , larger study samples are needed to strengthen our conclusion . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Intervention_Control, Participant_Condition, Outcome_Physical, Participant_Age
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Oral desensitization in papular urticaria in children . Papular urticaria ( PU ) is among the commonest skin ailments in children . Induced specific desensitization to insect bites is theoretically an effective means of prevention of PU . In this double blind placebo controlled study , an oral vaccine prepared from insect saliva was compared with placebo ( stable vaccine solvent ) . Vaccine and placebo effectiveness were tested by counting active PU lesions , serum eosinophils , and IgE , before and after 4 months of treatment . Statistically significant differences between oral vaccine and placebo were not found in the clinical or the immunological variables tested . We conclude that , although a lack of oral vaccine efficacy was suspected , larger study samples are needed to strengthen our conclusion .
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[ "Intervention_Pharmacological", "Intervention_Control", "Outcome_Physical", "Participant_Condition", "Participant_Age" ]
papular urticaria in is a Participant_Condition, children is a Participant_Age, . Papular urticaria is a Participant_Condition, placebo is a Intervention_Control, oral vaccine prepared from insect saliva is a Intervention_Pharmacological, placebo ( stable vaccine solvent ) . is a Intervention_Control, Vaccine is a Intervention_Pharmacological, counting active PU lesions is a Outcome_Physical, serum eosinophils is a Outcome_Physical, IgE is a Outcome_Physical
10006_task1
Sentence: Oral desensitization in papular urticaria in children . Papular urticaria ( PU ) is among the commonest skin ailments in children . Induced specific desensitization to insect bites is theoretically an effective means of prevention of PU . In this double blind placebo controlled study , an oral vaccine prepared from insect saliva was compared with placebo ( stable vaccine solvent ) . Vaccine and placebo effectiveness were tested by counting active PU lesions , serum eosinophils , and IgE , before and after 4 months of treatment . Statistically significant differences between oral vaccine and placebo were not found in the clinical or the immunological variables tested . We conclude that , although a lack of oral vaccine efficacy was suspected , larger study samples are needed to strengthen our conclusion . Instructions: please typing these entity words according to sentence: papular urticaria in, children, . Papular urticaria, placebo, oral vaccine prepared from insect saliva, placebo ( stable vaccine solvent ) ., Vaccine, counting active PU lesions, serum eosinophils, IgE Options: Intervention_Pharmacological, Intervention_Control, Participant_Condition, Outcome_Physical, Participant_Age
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Oral desensitization in papular urticaria in children . Papular urticaria ( PU ) is among the commonest skin ailments in children . Induced specific desensitization to insect bites is theoretically an effective means of prevention of PU . In this double blind placebo controlled study , an oral vaccine prepared from insect saliva was compared with placebo ( stable vaccine solvent ) . Vaccine and placebo effectiveness were tested by counting active PU lesions , serum eosinophils , and IgE , before and after 4 months of treatment . Statistically significant differences between oral vaccine and placebo were not found in the clinical or the immunological variables tested . We conclude that , although a lack of oral vaccine efficacy was suspected , larger study samples are needed to strengthen our conclusion .
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[ "Intervention_Pharmacological", "Intervention_Control", "Outcome_Physical", "Participant_Condition", "Participant_Age" ]
papular urticaria in, children, . Papular urticaria, placebo, oral vaccine prepared from insect saliva, placebo ( stable vaccine solvent ) ., Vaccine, counting active PU lesions, serum eosinophils, IgE
10006_task2
Sentence: Oral desensitization in papular urticaria in children . Papular urticaria ( PU ) is among the commonest skin ailments in children . Induced specific desensitization to insect bites is theoretically an effective means of prevention of PU . In this double blind placebo controlled study , an oral vaccine prepared from insect saliva was compared with placebo ( stable vaccine solvent ) . Vaccine and placebo effectiveness were tested by counting active PU lesions , serum eosinophils , and IgE , before and after 4 months of treatment . Statistically significant differences between oral vaccine and placebo were not found in the clinical or the immunological variables tested . We conclude that , although a lack of oral vaccine efficacy was suspected , larger study samples are needed to strengthen our conclusion . Instructions: please extract entity words from the input sentence
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Oral desensitization in papular urticaria in children . Papular urticaria ( PU ) is among the commonest skin ailments in children . Induced specific desensitization to insect bites is theoretically an effective means of prevention of PU . In this double blind placebo controlled study , an oral vaccine prepared from insect saliva was compared with placebo ( stable vaccine solvent ) . Vaccine and placebo effectiveness were tested by counting active PU lesions , serum eosinophils , and IgE , before and after 4 months of treatment . Statistically significant differences between oral vaccine and placebo were not found in the clinical or the immunological variables tested . We conclude that , although a lack of oral vaccine efficacy was suspected , larger study samples are needed to strengthen our conclusion .
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[ "Intervention_Pharmacological", "Intervention_Control", "Outcome_Physical", "Participant_Condition", "Participant_Age" ]
Hormone replacement therapy is an umlsterm, risk of is an umlsterm, breast cancer is an umlsterm, treatment is an umlsterm, periods is an umlsterm, risk is an umlsterm, breast cancer is an umlsterm, risks is an umlsterm, patients is an umlsterm, estrogen is an umlsterm, therapy is an umlsterm, breast cancer is an umlsterm, patients is an umlsterm, symptoms is an umlsterm
DerGynaekologe.00330402.eng.abstr_task0
Sentence: Hormone replacement therapy ( HRT ) for up to 5 years does not increase the risk of breast cancer . Longer treatment periods lead to minimal increases in risk . Although the benefits of HRT are clear increases in breast cancer risks have to be discussed with the patients when long-term application of estrogen is performed . After primary therapy of breast cancer HRT ist contraindicated . However , it may be performed in indivudual cases when alternatives have been shown to be ineffective . This group of patients mainly suffers from severe vasomotor symptoms . Nonhormonal alternatives are often without success . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O" ]
Hormone replacement therapy ( HRT ) for up to 5 years does not increase the risk of breast cancer . Longer treatment periods lead to minimal increases in risk . Although the benefits of HRT are clear increases in breast cancer risks have to be discussed with the patients when long-term application of estrogen is performed . After primary therapy of breast cancer HRT ist contraindicated . However , it may be performed in indivudual cases when alternatives have been shown to be ineffective . This group of patients mainly suffers from severe vasomotor symptoms . Nonhormonal alternatives are often without success .
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[ "umlsterm" ]
Hormone replacement therapy is an umlsterm, risk of is an umlsterm, breast cancer is an umlsterm, treatment is an umlsterm, periods is an umlsterm, risk is an umlsterm, breast cancer is an umlsterm, risks is an umlsterm, patients is an umlsterm, estrogen is an umlsterm, therapy is an umlsterm, breast cancer is an umlsterm, patients is an umlsterm, symptoms is an umlsterm
DerGynaekologe.00330402.eng.abstr_task1
Sentence: Hormone replacement therapy ( HRT ) for up to 5 years does not increase the risk of breast cancer . Longer treatment periods lead to minimal increases in risk . Although the benefits of HRT are clear increases in breast cancer risks have to be discussed with the patients when long-term application of estrogen is performed . After primary therapy of breast cancer HRT ist contraindicated . However , it may be performed in indivudual cases when alternatives have been shown to be ineffective . This group of patients mainly suffers from severe vasomotor symptoms . Nonhormonal alternatives are often without success . Instructions: please typing these entity words according to sentence: Hormone replacement therapy, risk of, breast cancer, treatment, periods, risk, breast cancer, risks, patients, estrogen, therapy, breast cancer, patients, symptoms Options: umlsterm
[ "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O" ]
Hormone replacement therapy ( HRT ) for up to 5 years does not increase the risk of breast cancer . Longer treatment periods lead to minimal increases in risk . Although the benefits of HRT are clear increases in breast cancer risks have to be discussed with the patients when long-term application of estrogen is performed . After primary therapy of breast cancer HRT ist contraindicated . However , it may be performed in indivudual cases when alternatives have been shown to be ineffective . This group of patients mainly suffers from severe vasomotor symptoms . Nonhormonal alternatives are often without success .
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[ "umlsterm" ]
Hormone replacement therapy, risk of, breast cancer, treatment, periods, risk, breast cancer, risks, patients, estrogen, therapy, breast cancer, patients, symptoms
DerGynaekologe.00330402.eng.abstr_task2
Sentence: Hormone replacement therapy ( HRT ) for up to 5 years does not increase the risk of breast cancer . Longer treatment periods lead to minimal increases in risk . Although the benefits of HRT are clear increases in breast cancer risks have to be discussed with the patients when long-term application of estrogen is performed . After primary therapy of breast cancer HRT ist contraindicated . However , it may be performed in indivudual cases when alternatives have been shown to be ineffective . This group of patients mainly suffers from severe vasomotor symptoms . Nonhormonal alternatives are often without success . Instructions: please extract entity words from the input sentence
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Hormone replacement therapy ( HRT ) for up to 5 years does not increase the risk of breast cancer . Longer treatment periods lead to minimal increases in risk . Although the benefits of HRT are clear increases in breast cancer risks have to be discussed with the patients when long-term application of estrogen is performed . After primary therapy of breast cancer HRT ist contraindicated . However , it may be performed in indivudual cases when alternatives have been shown to be ineffective . This group of patients mainly suffers from severe vasomotor symptoms . Nonhormonal alternatives are often without success .
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[ "umlsterm" ]
ferredoxin reductase is a Gene, FDXR is a Gene, cyclin - dependent kinase inhibitor 1A is a Gene, CDKN1A is a Gene, FDXR is a Gene
250_task0
Sentence: Genetic variation in radiation-induced expression phenotypes. Studies have demonstrated that natural variation in the expression level of genes at baseline is extensive, and the determinants of this variation can be mapped by a genetic-linkage approach. In this study, we used lymphoblastoid cells to explore the variation in radiation-induced transcriptional changes. We found that, among normal individuals, there is extensive variation in transcriptional response to radiation exposure. By studying monozygotic twins, we demonstrated that there is evidence of a heritable component to this variation. The postradiation variation in the expression level of several genes, including the ferredoxin reductase gene (FDXR) and the cyclin-dependent kinase inhibitor 1A gene (CDKN1A), is significantly greater (P<.001) among twin pairs than within twin pairs. The induction of FDXR by radiation showed a bimodal distribution. Our findings have important implications for understanding the genetic basis of radiation response, which has remained largely unknown due to the lack of family material needed for genetic studies. Our approach, which uses expression phenotypes in cell lines, allows us to expose cells from family members to radiation. Similar study design can be applied to dissect the genetic basis of other complex human traits. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Gene
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Genetic variation in radiation-induced expression phenotypes. Studies have demonstrated that natural variation in the expression level of genes at baseline is extensive, and the determinants of this variation can be mapped by a genetic-linkage approach. In this study, we used lymphoblastoid cells to explore the variation in radiation-induced transcriptional changes. We found that, among normal individuals, there is extensive variation in transcriptional response to radiation exposure. By studying monozygotic twins, we demonstrated that there is evidence of a heritable component to this variation. The postradiation variation in the expression level of several genes, including the ferredoxin reductase gene (FDXR) and the cyclin-dependent kinase inhibitor 1A gene (CDKN1A), is significantly greater (P<.001) among twin pairs than within twin pairs. The induction of FDXR by radiation showed a bimodal distribution. Our findings have important implications for understanding the genetic basis of radiation response, which has remained largely unknown due to the lack of family material needed for genetic studies. Our approach, which uses expression phenotypes in cell lines, allows us to expose cells from family members to radiation. Similar study design can be applied to dissect the genetic basis of other complex human traits.
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[ "Gene" ]
ferredoxin reductase is a Gene, FDXR is a Gene, cyclin - dependent kinase inhibitor 1A is a Gene, CDKN1A is a Gene, FDXR is a Gene
250_task1
Sentence: Genetic variation in radiation-induced expression phenotypes. Studies have demonstrated that natural variation in the expression level of genes at baseline is extensive, and the determinants of this variation can be mapped by a genetic-linkage approach. In this study, we used lymphoblastoid cells to explore the variation in radiation-induced transcriptional changes. We found that, among normal individuals, there is extensive variation in transcriptional response to radiation exposure. By studying monozygotic twins, we demonstrated that there is evidence of a heritable component to this variation. The postradiation variation in the expression level of several genes, including the ferredoxin reductase gene (FDXR) and the cyclin-dependent kinase inhibitor 1A gene (CDKN1A), is significantly greater (P<.001) among twin pairs than within twin pairs. The induction of FDXR by radiation showed a bimodal distribution. Our findings have important implications for understanding the genetic basis of radiation response, which has remained largely unknown due to the lack of family material needed for genetic studies. Our approach, which uses expression phenotypes in cell lines, allows us to expose cells from family members to radiation. Similar study design can be applied to dissect the genetic basis of other complex human traits. Instructions: please typing these entity words according to sentence: ferredoxin reductase, FDXR, cyclin - dependent kinase inhibitor 1A, CDKN1A, FDXR Options: Gene
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Genetic variation in radiation-induced expression phenotypes. Studies have demonstrated that natural variation in the expression level of genes at baseline is extensive, and the determinants of this variation can be mapped by a genetic-linkage approach. In this study, we used lymphoblastoid cells to explore the variation in radiation-induced transcriptional changes. We found that, among normal individuals, there is extensive variation in transcriptional response to radiation exposure. By studying monozygotic twins, we demonstrated that there is evidence of a heritable component to this variation. The postradiation variation in the expression level of several genes, including the ferredoxin reductase gene (FDXR) and the cyclin-dependent kinase inhibitor 1A gene (CDKN1A), is significantly greater (P<.001) among twin pairs than within twin pairs. The induction of FDXR by radiation showed a bimodal distribution. Our findings have important implications for understanding the genetic basis of radiation response, which has remained largely unknown due to the lack of family material needed for genetic studies. Our approach, which uses expression phenotypes in cell lines, allows us to expose cells from family members to radiation. Similar study design can be applied to dissect the genetic basis of other complex human traits.
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[ "Gene" ]
ferredoxin reductase, FDXR, cyclin - dependent kinase inhibitor 1A, CDKN1A, FDXR
250_task2
Sentence: Genetic variation in radiation-induced expression phenotypes. Studies have demonstrated that natural variation in the expression level of genes at baseline is extensive, and the determinants of this variation can be mapped by a genetic-linkage approach. In this study, we used lymphoblastoid cells to explore the variation in radiation-induced transcriptional changes. We found that, among normal individuals, there is extensive variation in transcriptional response to radiation exposure. By studying monozygotic twins, we demonstrated that there is evidence of a heritable component to this variation. The postradiation variation in the expression level of several genes, including the ferredoxin reductase gene (FDXR) and the cyclin-dependent kinase inhibitor 1A gene (CDKN1A), is significantly greater (P<.001) among twin pairs than within twin pairs. The induction of FDXR by radiation showed a bimodal distribution. Our findings have important implications for understanding the genetic basis of radiation response, which has remained largely unknown due to the lack of family material needed for genetic studies. Our approach, which uses expression phenotypes in cell lines, allows us to expose cells from family members to radiation. Similar study design can be applied to dissect the genetic basis of other complex human traits. Instructions: please extract entity words from the input sentence
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Genetic variation in radiation-induced expression phenotypes. Studies have demonstrated that natural variation in the expression level of genes at baseline is extensive, and the determinants of this variation can be mapped by a genetic-linkage approach. In this study, we used lymphoblastoid cells to explore the variation in radiation-induced transcriptional changes. We found that, among normal individuals, there is extensive variation in transcriptional response to radiation exposure. By studying monozygotic twins, we demonstrated that there is evidence of a heritable component to this variation. The postradiation variation in the expression level of several genes, including the ferredoxin reductase gene (FDXR) and the cyclin-dependent kinase inhibitor 1A gene (CDKN1A), is significantly greater (P<.001) among twin pairs than within twin pairs. The induction of FDXR by radiation showed a bimodal distribution. Our findings have important implications for understanding the genetic basis of radiation response, which has remained largely unknown due to the lack of family material needed for genetic studies. Our approach, which uses expression phenotypes in cell lines, allows us to expose cells from family members to radiation. Similar study design can be applied to dissect the genetic basis of other complex human traits.
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[ "Gene" ]
Patienten is an umlsterm, Schmerzen is an umlsterm, Becken is an umlsterm, Beckenverletzung is an umlsterm, Beckenverletzung is an umlsterm, Beckenverletzungen is an umlsterm, Frakturformen is an umlsterm, Komplikationen is an umlsterm, Anatomie is an umlsterm, Beckenrings is an umlsterm, heterotope Ossifikationen is an umlsterm, Beckenanatomie is an umlsterm, Beckens is an umlsterm, Kontrakturen is an umlsterm, Natur is an umlsterm, Beckenknochens is an umlsterm, Verletzung is an umlsterm, Risiko is an umlsterm, Verletzung is an umlsterm, Plexus lumbosacralis is an umlsterm, Beckenfixation is an umlsterm, Beckenringrekonstruktion is an umlsterm, Patient is an umlsterm, Truemmerfraktur is an umlsterm, Ermuedungsfrakturen is an umlsterm, Techniken is an umlsterm
DerOrthopaede.60250441.ger.abstr_task0
Sentence: Beckenpseudarthrosen und Fehlstellungen umfassen ein weites Spektrum von klinischen Problemen , die Patienten leiden sowohl unter den Schmerzen im Becken , der Instabilitaet und der Fehlstellung . Nur ein geringer Anteil dieser Faelle ist Folge einer Beckenverletzung des Typs A oder B , die meisten Fehlstellungen sind Resultate einer instabilen Beckenverletzung des Typs C , die primaer entweder rein konservativ oder nur durch externe Fixation behandelt wurde . Die wichtigste Schlussfolgerung muss deswegen sein , dass die meisten Beckenpseudarthrosen oder Fehlstellungen durch die konsequente fruehzeitige interne Fixation instabiler Beckenverletzungen vermieden werden koennen . Da eine grosse Anzahl von Stabilisationstechniken entwickelt wurde , ist zwischenzeitlich fuer nahezu alle Frakturformen eine effektive Osteosynthesetechnik verfuegbar , auch fuer solche Faelle bei denen die Versorgung durch Komplikationen erschwert wird . Ist die Anatomie des Beckenrings durch das Vorliegen der Fehlstellung , durch heterotope Ossifikationen und Narbengewebe gestoert , ist eine umfassende Kenntnis der Beckenanatomie notwendig . Die Korrektur der Fehlstellung und die Stabilisierung des Beckens sind durch die typischen sehr straffen Kontrakturen und die an sich osteoporotische Natur des Beckenknochens erschwert . In den Faellen , in denen die hintere Fehlstellung das Sakrums mit einschliesst , insbesondere wenn sie als Folge einer transforaminalen Verletzung mit vertikaler oder sagittaler Rotationsfehlstellung aufgetreten ist , muss das Risiko einer iatrogenen Verletzung des Plexus lumbosacralis unbedingt beruecksichtigt werden . In diesen Faellen kann es guenstiger sein , das Sakrum in situ zu stabilisieren und die Fehlstellung durch eine laterale Iliumosteotomie zu korrigieren . Das Konzept der Saeulen " der Beckenfixation " ist hilfreich . In den meisten Faellen der spaeten Beckenringrekonstruktion ist die Fixation der vorderen und mittleren bzw. hinteren Saeule notwendig . Ist der Patient sehr gross , ist er unzuverlaessig , oder besteht eine Truemmerfraktur sollten immer alle 3 Saeulen fixiert werden . Zur Stabilisierung von Ermuedungsfrakturen wird die Fixation der hinteren und mittleren Saeule bevorzugt . Mit den bisher verfuegbaren Techniken laesst sich der Zustand bei den meisten symptomatischen Fehlstellungen oder Pseudarthrosen deutlich verbessern , obwohl haeufig eine exakt anatomische Rekonstruktion nicht erreicht werden kann . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Beckenpseudarthrosen und Fehlstellungen umfassen ein weites Spektrum von klinischen Problemen , die Patienten leiden sowohl unter den Schmerzen im Becken , der Instabilitaet und der Fehlstellung . Nur ein geringer Anteil dieser Faelle ist Folge einer Beckenverletzung des Typs A oder B , die meisten Fehlstellungen sind Resultate einer instabilen Beckenverletzung des Typs C , die primaer entweder rein konservativ oder nur durch externe Fixation behandelt wurde . Die wichtigste Schlussfolgerung muss deswegen sein , dass die meisten Beckenpseudarthrosen oder Fehlstellungen durch die konsequente fruehzeitige interne Fixation instabiler Beckenverletzungen vermieden werden koennen . Da eine grosse Anzahl von Stabilisationstechniken entwickelt wurde , ist zwischenzeitlich fuer nahezu alle Frakturformen eine effektive Osteosynthesetechnik verfuegbar , auch fuer solche Faelle bei denen die Versorgung durch Komplikationen erschwert wird . Ist die Anatomie des Beckenrings durch das Vorliegen der Fehlstellung , durch heterotope Ossifikationen und Narbengewebe gestoert , ist eine umfassende Kenntnis der Beckenanatomie notwendig . Die Korrektur der Fehlstellung und die Stabilisierung des Beckens sind durch die typischen sehr straffen Kontrakturen und die an sich osteoporotische Natur des Beckenknochens erschwert . In den Faellen , in denen die hintere Fehlstellung das Sakrums mit einschliesst , insbesondere wenn sie als Folge einer transforaminalen Verletzung mit vertikaler oder sagittaler Rotationsfehlstellung aufgetreten ist , muss das Risiko einer iatrogenen Verletzung des Plexus lumbosacralis unbedingt beruecksichtigt werden . In diesen Faellen kann es guenstiger sein , das Sakrum in situ zu stabilisieren und die Fehlstellung durch eine laterale Iliumosteotomie zu korrigieren . Das Konzept der Saeulen " der Beckenfixation " ist hilfreich . In den meisten Faellen der spaeten Beckenringrekonstruktion ist die Fixation der vorderen und mittleren bzw. hinteren Saeule notwendig . Ist der Patient sehr gross , ist er unzuverlaessig , oder besteht eine Truemmerfraktur sollten immer alle 3 Saeulen fixiert werden . Zur Stabilisierung von Ermuedungsfrakturen wird die Fixation der hinteren und mittleren Saeule bevorzugt . Mit den bisher verfuegbaren Techniken laesst sich der Zustand bei den meisten symptomatischen Fehlstellungen oder Pseudarthrosen deutlich verbessern , obwohl haeufig eine exakt anatomische Rekonstruktion nicht erreicht werden kann .
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[ "umlsterm" ]
Patienten is an umlsterm, Schmerzen is an umlsterm, Becken is an umlsterm, Beckenverletzung is an umlsterm, Beckenverletzung is an umlsterm, Beckenverletzungen is an umlsterm, Frakturformen is an umlsterm, Komplikationen is an umlsterm, Anatomie is an umlsterm, Beckenrings is an umlsterm, heterotope Ossifikationen is an umlsterm, Beckenanatomie is an umlsterm, Beckens is an umlsterm, Kontrakturen is an umlsterm, Natur is an umlsterm, Beckenknochens is an umlsterm, Verletzung is an umlsterm, Risiko is an umlsterm, Verletzung is an umlsterm, Plexus lumbosacralis is an umlsterm, Beckenfixation is an umlsterm, Beckenringrekonstruktion is an umlsterm, Patient is an umlsterm, Truemmerfraktur is an umlsterm, Ermuedungsfrakturen is an umlsterm, Techniken is an umlsterm
DerOrthopaede.60250441.ger.abstr_task1
Sentence: Beckenpseudarthrosen und Fehlstellungen umfassen ein weites Spektrum von klinischen Problemen , die Patienten leiden sowohl unter den Schmerzen im Becken , der Instabilitaet und der Fehlstellung . Nur ein geringer Anteil dieser Faelle ist Folge einer Beckenverletzung des Typs A oder B , die meisten Fehlstellungen sind Resultate einer instabilen Beckenverletzung des Typs C , die primaer entweder rein konservativ oder nur durch externe Fixation behandelt wurde . Die wichtigste Schlussfolgerung muss deswegen sein , dass die meisten Beckenpseudarthrosen oder Fehlstellungen durch die konsequente fruehzeitige interne Fixation instabiler Beckenverletzungen vermieden werden koennen . Da eine grosse Anzahl von Stabilisationstechniken entwickelt wurde , ist zwischenzeitlich fuer nahezu alle Frakturformen eine effektive Osteosynthesetechnik verfuegbar , auch fuer solche Faelle bei denen die Versorgung durch Komplikationen erschwert wird . Ist die Anatomie des Beckenrings durch das Vorliegen der Fehlstellung , durch heterotope Ossifikationen und Narbengewebe gestoert , ist eine umfassende Kenntnis der Beckenanatomie notwendig . Die Korrektur der Fehlstellung und die Stabilisierung des Beckens sind durch die typischen sehr straffen Kontrakturen und die an sich osteoporotische Natur des Beckenknochens erschwert . In den Faellen , in denen die hintere Fehlstellung das Sakrums mit einschliesst , insbesondere wenn sie als Folge einer transforaminalen Verletzung mit vertikaler oder sagittaler Rotationsfehlstellung aufgetreten ist , muss das Risiko einer iatrogenen Verletzung des Plexus lumbosacralis unbedingt beruecksichtigt werden . In diesen Faellen kann es guenstiger sein , das Sakrum in situ zu stabilisieren und die Fehlstellung durch eine laterale Iliumosteotomie zu korrigieren . Das Konzept der Saeulen " der Beckenfixation " ist hilfreich . In den meisten Faellen der spaeten Beckenringrekonstruktion ist die Fixation der vorderen und mittleren bzw. hinteren Saeule notwendig . Ist der Patient sehr gross , ist er unzuverlaessig , oder besteht eine Truemmerfraktur sollten immer alle 3 Saeulen fixiert werden . Zur Stabilisierung von Ermuedungsfrakturen wird die Fixation der hinteren und mittleren Saeule bevorzugt . Mit den bisher verfuegbaren Techniken laesst sich der Zustand bei den meisten symptomatischen Fehlstellungen oder Pseudarthrosen deutlich verbessern , obwohl haeufig eine exakt anatomische Rekonstruktion nicht erreicht werden kann . Instructions: please typing these entity words according to sentence: Patienten, Schmerzen, Becken, Beckenverletzung, Beckenverletzung, Beckenverletzungen, Frakturformen, Komplikationen, Anatomie, Beckenrings, heterotope Ossifikationen, Beckenanatomie, Beckens, Kontrakturen, Natur, Beckenknochens, Verletzung, Risiko, Verletzung, Plexus lumbosacralis, Beckenfixation, Beckenringrekonstruktion, Patient, Truemmerfraktur, Ermuedungsfrakturen, Techniken Options: umlsterm
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Beckenpseudarthrosen und Fehlstellungen umfassen ein weites Spektrum von klinischen Problemen , die Patienten leiden sowohl unter den Schmerzen im Becken , der Instabilitaet und der Fehlstellung . Nur ein geringer Anteil dieser Faelle ist Folge einer Beckenverletzung des Typs A oder B , die meisten Fehlstellungen sind Resultate einer instabilen Beckenverletzung des Typs C , die primaer entweder rein konservativ oder nur durch externe Fixation behandelt wurde . Die wichtigste Schlussfolgerung muss deswegen sein , dass die meisten Beckenpseudarthrosen oder Fehlstellungen durch die konsequente fruehzeitige interne Fixation instabiler Beckenverletzungen vermieden werden koennen . Da eine grosse Anzahl von Stabilisationstechniken entwickelt wurde , ist zwischenzeitlich fuer nahezu alle Frakturformen eine effektive Osteosynthesetechnik verfuegbar , auch fuer solche Faelle bei denen die Versorgung durch Komplikationen erschwert wird . Ist die Anatomie des Beckenrings durch das Vorliegen der Fehlstellung , durch heterotope Ossifikationen und Narbengewebe gestoert , ist eine umfassende Kenntnis der Beckenanatomie notwendig . Die Korrektur der Fehlstellung und die Stabilisierung des Beckens sind durch die typischen sehr straffen Kontrakturen und die an sich osteoporotische Natur des Beckenknochens erschwert . In den Faellen , in denen die hintere Fehlstellung das Sakrums mit einschliesst , insbesondere wenn sie als Folge einer transforaminalen Verletzung mit vertikaler oder sagittaler Rotationsfehlstellung aufgetreten ist , muss das Risiko einer iatrogenen Verletzung des Plexus lumbosacralis unbedingt beruecksichtigt werden . In diesen Faellen kann es guenstiger sein , das Sakrum in situ zu stabilisieren und die Fehlstellung durch eine laterale Iliumosteotomie zu korrigieren . Das Konzept der Saeulen " der Beckenfixation " ist hilfreich . In den meisten Faellen der spaeten Beckenringrekonstruktion ist die Fixation der vorderen und mittleren bzw. hinteren Saeule notwendig . Ist der Patient sehr gross , ist er unzuverlaessig , oder besteht eine Truemmerfraktur sollten immer alle 3 Saeulen fixiert werden . Zur Stabilisierung von Ermuedungsfrakturen wird die Fixation der hinteren und mittleren Saeule bevorzugt . Mit den bisher verfuegbaren Techniken laesst sich der Zustand bei den meisten symptomatischen Fehlstellungen oder Pseudarthrosen deutlich verbessern , obwohl haeufig eine exakt anatomische Rekonstruktion nicht erreicht werden kann .
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[ "umlsterm" ]
Patienten, Schmerzen, Becken, Beckenverletzung, Beckenverletzung, Beckenverletzungen, Frakturformen, Komplikationen, Anatomie, Beckenrings, heterotope Ossifikationen, Beckenanatomie, Beckens, Kontrakturen, Natur, Beckenknochens, Verletzung, Risiko, Verletzung, Plexus lumbosacralis, Beckenfixation, Beckenringrekonstruktion, Patient, Truemmerfraktur, Ermuedungsfrakturen, Techniken
DerOrthopaede.60250441.ger.abstr_task2
Sentence: Beckenpseudarthrosen und Fehlstellungen umfassen ein weites Spektrum von klinischen Problemen , die Patienten leiden sowohl unter den Schmerzen im Becken , der Instabilitaet und der Fehlstellung . Nur ein geringer Anteil dieser Faelle ist Folge einer Beckenverletzung des Typs A oder B , die meisten Fehlstellungen sind Resultate einer instabilen Beckenverletzung des Typs C , die primaer entweder rein konservativ oder nur durch externe Fixation behandelt wurde . Die wichtigste Schlussfolgerung muss deswegen sein , dass die meisten Beckenpseudarthrosen oder Fehlstellungen durch die konsequente fruehzeitige interne Fixation instabiler Beckenverletzungen vermieden werden koennen . Da eine grosse Anzahl von Stabilisationstechniken entwickelt wurde , ist zwischenzeitlich fuer nahezu alle Frakturformen eine effektive Osteosynthesetechnik verfuegbar , auch fuer solche Faelle bei denen die Versorgung durch Komplikationen erschwert wird . Ist die Anatomie des Beckenrings durch das Vorliegen der Fehlstellung , durch heterotope Ossifikationen und Narbengewebe gestoert , ist eine umfassende Kenntnis der Beckenanatomie notwendig . Die Korrektur der Fehlstellung und die Stabilisierung des Beckens sind durch die typischen sehr straffen Kontrakturen und die an sich osteoporotische Natur des Beckenknochens erschwert . In den Faellen , in denen die hintere Fehlstellung das Sakrums mit einschliesst , insbesondere wenn sie als Folge einer transforaminalen Verletzung mit vertikaler oder sagittaler Rotationsfehlstellung aufgetreten ist , muss das Risiko einer iatrogenen Verletzung des Plexus lumbosacralis unbedingt beruecksichtigt werden . In diesen Faellen kann es guenstiger sein , das Sakrum in situ zu stabilisieren und die Fehlstellung durch eine laterale Iliumosteotomie zu korrigieren . Das Konzept der Saeulen " der Beckenfixation " ist hilfreich . In den meisten Faellen der spaeten Beckenringrekonstruktion ist die Fixation der vorderen und mittleren bzw. hinteren Saeule notwendig . Ist der Patient sehr gross , ist er unzuverlaessig , oder besteht eine Truemmerfraktur sollten immer alle 3 Saeulen fixiert werden . Zur Stabilisierung von Ermuedungsfrakturen wird die Fixation der hinteren und mittleren Saeule bevorzugt . Mit den bisher verfuegbaren Techniken laesst sich der Zustand bei den meisten symptomatischen Fehlstellungen oder Pseudarthrosen deutlich verbessern , obwohl haeufig eine exakt anatomische Rekonstruktion nicht erreicht werden kann . Instructions: please extract entity words from the input sentence
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Beckenpseudarthrosen und Fehlstellungen umfassen ein weites Spektrum von klinischen Problemen , die Patienten leiden sowohl unter den Schmerzen im Becken , der Instabilitaet und der Fehlstellung . Nur ein geringer Anteil dieser Faelle ist Folge einer Beckenverletzung des Typs A oder B , die meisten Fehlstellungen sind Resultate einer instabilen Beckenverletzung des Typs C , die primaer entweder rein konservativ oder nur durch externe Fixation behandelt wurde . Die wichtigste Schlussfolgerung muss deswegen sein , dass die meisten Beckenpseudarthrosen oder Fehlstellungen durch die konsequente fruehzeitige interne Fixation instabiler Beckenverletzungen vermieden werden koennen . Da eine grosse Anzahl von Stabilisationstechniken entwickelt wurde , ist zwischenzeitlich fuer nahezu alle Frakturformen eine effektive Osteosynthesetechnik verfuegbar , auch fuer solche Faelle bei denen die Versorgung durch Komplikationen erschwert wird . Ist die Anatomie des Beckenrings durch das Vorliegen der Fehlstellung , durch heterotope Ossifikationen und Narbengewebe gestoert , ist eine umfassende Kenntnis der Beckenanatomie notwendig . Die Korrektur der Fehlstellung und die Stabilisierung des Beckens sind durch die typischen sehr straffen Kontrakturen und die an sich osteoporotische Natur des Beckenknochens erschwert . In den Faellen , in denen die hintere Fehlstellung das Sakrums mit einschliesst , insbesondere wenn sie als Folge einer transforaminalen Verletzung mit vertikaler oder sagittaler Rotationsfehlstellung aufgetreten ist , muss das Risiko einer iatrogenen Verletzung des Plexus lumbosacralis unbedingt beruecksichtigt werden . In diesen Faellen kann es guenstiger sein , das Sakrum in situ zu stabilisieren und die Fehlstellung durch eine laterale Iliumosteotomie zu korrigieren . Das Konzept der Saeulen " der Beckenfixation " ist hilfreich . In den meisten Faellen der spaeten Beckenringrekonstruktion ist die Fixation der vorderen und mittleren bzw. hinteren Saeule notwendig . Ist der Patient sehr gross , ist er unzuverlaessig , oder besteht eine Truemmerfraktur sollten immer alle 3 Saeulen fixiert werden . Zur Stabilisierung von Ermuedungsfrakturen wird die Fixation der hinteren und mittleren Saeule bevorzugt . Mit den bisher verfuegbaren Techniken laesst sich der Zustand bei den meisten symptomatischen Fehlstellungen oder Pseudarthrosen deutlich verbessern , obwohl haeufig eine exakt anatomische Rekonstruktion nicht erreicht werden kann .
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[ "umlsterm" ]
angiosarcomas is a MORFOLOGIA_NEOPLASIA, neoplasias is a MORFOLOGIA_NEOPLASIA, adenocarcinoma is a MORFOLOGIA_NEOPLASIA, pT2aN0M0 is a MORFOLOGIA_NEOPLASIA, angiosarcoma is a MORFOLOGIA_NEOPLASIA, metastásica is a MORFOLOGIA_NEOPLASIA, tumoración is a MORFOLOGIA_NEOPLASIA, angiosarcoma moderadamente diferenciado is a MORFOLOGIA_NEOPLASIA, angiosarcoma is a MORFOLOGIA_NEOPLASIA, enfermedad a distancia is a MORFOLOGIA_NEOPLASIA
913_task0
Sentence: Anamnesis Los angiosarcomas cutáneos son neoplasias raras que fundamentalmente se diagnostican en cuero cabelludo y región facial en personas con avanzada edad. También pueden desarrollarse en áreas de linfedema crónico secundario a mastectomía radical, denominándose en este caso "Síndrome de Stewart-Treves", y en regiones que han sido irradiadas como parte de tratamientos complementarios. Presentamos el caso de una paciente de 72 años en la actualidad, natural de Elche, diagnosticada en 2012 de un adenocarcinoma de endocérvix pT2aN0M0. Como tratamiento, se realizó una histerectomía radical con linfadenectomía pélvica tipo Werthein-Meigs en abril de 2012, y posteriormente recibió tratamiento con radioterapia (sobre lecho + margen, cadenas ganglionares regionales y tercio superior de vagina) y quimioterapia (cisplatino 40 mg/m2/semanal) concomitantes durante 6 semanas, seguido de braquiterapia endovaginal que finalizó en agosto de 2012. Como otros antecedentes personales de interés, presentaba una insuficiencia venosa crónica en miembros inferiores y una linfedema en miembro inferior izquierdo residual tras cirugía. Continúa seguimientos periódicos en consultas externas, con controles analíticos e iconográficos que son repetidamente normales, hasta noviembre de 2016, cuando refiere notar en fosa iliaca izquierda, en la cicatriz donde se insertó en 2012 un drenaje abdominal posquirúrgico, una erupción violácea que la paciente relacionaba con una posible picadura de insecto. Exploración física IK 90. Buen estado general, consciente y orientada en tiempo, espacio y persona. Normonutrida y normocoloreada. Eupneica en reposo sin oxígeno suplementario. AC: rítmica, sin soplos. AP: murmullo vesicular conservado. No se auscultan ruidos sobreañadidos. Abdomen: se observa en fosa iliaca izquierda una placa indurada eritematoviolácea de aparición progresiva, con componente vascular y que no blanquea a la digitopresión. No tiene orificios de entrada. No hay dolor a la palpación profunda. No se palpan masas o megalias. Miembros inferiores: linfedema crónica en miembro inferior izquierdo y signos de insuficiencia venosa crónica. Neurológico: exploración básica dentro de la normalidad. Pruebas complementarias Dadas las características de la lesión cutánea, se deriva de forma preferente a Dermatología, quienes realizan biopsia de la lesión. Posteriormente, se solicita un estudio de extensión con TC de tórax, abdomen y pelvis. Diagnóstico El diagnóstico patológico es finalmente compatible con angiosarcoma cutáneo, CD 34 y CD 31 +, Ki 67 > 20 %. En el estudio de extensión, no se identifican nódulos o masas ni adenopatías patológicas en las regiones inguinales, ni tampoco hay evidencia de afectación ganglionar o metastásica a distancia. Tratamiento Fue derivada a la Unidad de Tumores Musculoesqueléticos de referencia en diciembre de 2016, realizándose el 21/03/2017 una exéresis ampliada de la tumoración en zona inguinal izquierda. La anatomía patológica informa de un angiosarcoma moderadamente diferenciado, con márgenes quirúrgicos libres de enfermedad. No obstante, cuando la paciente acude a consultas externas de Oncología Médica tras su intervención, se constata nueva aparición de lesiones cutáneas de características similares en fosa iliaca derecha y muslo derecho. Se realiza biopsia que confirma de nuevo el diagnóstico de angiosarcoma, y se solicita un estudio de extensión que no muestra diseminación locorregional o enfermedad a distancia. Se propone tratamiento con radioterapia y quimioterapia concomitantes. El 23/05/2017 inicia radioterapia con paclitaxel semanal (80 mg/m2). Evolución Hasta el momento, la paciente lleva 4 semanas de tratamiento con muy buena tolerancia y sin toxicidad relevante. Las lesiones cutáneas se encuentran en remisión, no siendo visibles en la actualidad. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: MORFOLOGIA_NEOPLASIA
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Anamnesis Los angiosarcomas cutáneos son neoplasias raras que fundamentalmente se diagnostican en cuero cabelludo y región facial en personas con avanzada edad. También pueden desarrollarse en áreas de linfedema crónico secundario a mastectomía radical, denominándose en este caso "Síndrome de Stewart-Treves", y en regiones que han sido irradiadas como parte de tratamientos complementarios. Presentamos el caso de una paciente de 72 años en la actualidad, natural de Elche, diagnosticada en 2012 de un adenocarcinoma de endocérvix pT2aN0M0. Como tratamiento, se realizó una histerectomía radical con linfadenectomía pélvica tipo Werthein-Meigs en abril de 2012, y posteriormente recibió tratamiento con radioterapia (sobre lecho + margen, cadenas ganglionares regionales y tercio superior de vagina) y quimioterapia (cisplatino 40 mg/m2/semanal) concomitantes durante 6 semanas, seguido de braquiterapia endovaginal que finalizó en agosto de 2012. Como otros antecedentes personales de interés, presentaba una insuficiencia venosa crónica en miembros inferiores y una linfedema en miembro inferior izquierdo residual tras cirugía. Continúa seguimientos periódicos en consultas externas, con controles analíticos e iconográficos que son repetidamente normales, hasta noviembre de 2016, cuando refiere notar en fosa iliaca izquierda, en la cicatriz donde se insertó en 2012 un drenaje abdominal posquirúrgico, una erupción violácea que la paciente relacionaba con una posible picadura de insecto. Exploración física IK 90. Buen estado general, consciente y orientada en tiempo, espacio y persona. Normonutrida y normocoloreada. Eupneica en reposo sin oxígeno suplementario. AC: rítmica, sin soplos. AP: murmullo vesicular conservado. No se auscultan ruidos sobreañadidos. Abdomen: se observa en fosa iliaca izquierda una placa indurada eritematoviolácea de aparición progresiva, con componente vascular y que no blanquea a la digitopresión. No tiene orificios de entrada. No hay dolor a la palpación profunda. No se palpan masas o megalias. Miembros inferiores: linfedema crónica en miembro inferior izquierdo y signos de insuficiencia venosa crónica. Neurológico: exploración básica dentro de la normalidad. Pruebas complementarias Dadas las características de la lesión cutánea, se deriva de forma preferente a Dermatología, quienes realizan biopsia de la lesión. Posteriormente, se solicita un estudio de extensión con TC de tórax, abdomen y pelvis. Diagnóstico El diagnóstico patológico es finalmente compatible con angiosarcoma cutáneo, CD 34 y CD 31 +, Ki 67 > 20 %. En el estudio de extensión, no se identifican nódulos o masas ni adenopatías patológicas en las regiones inguinales, ni tampoco hay evidencia de afectación ganglionar o metastásica a distancia. Tratamiento Fue derivada a la Unidad de Tumores Musculoesqueléticos de referencia en diciembre de 2016, realizándose el 21/03/2017 una exéresis ampliada de la tumoración en zona inguinal izquierda. La anatomía patológica informa de un angiosarcoma moderadamente diferenciado, con márgenes quirúrgicos libres de enfermedad. No obstante, cuando la paciente acude a consultas externas de Oncología Médica tras su intervención, se constata nueva aparición de lesiones cutáneas de características similares en fosa iliaca derecha y muslo derecho. Se realiza biopsia que confirma de nuevo el diagnóstico de angiosarcoma, y se solicita un estudio de extensión que no muestra diseminación locorregional o enfermedad a distancia. Se propone tratamiento con radioterapia y quimioterapia concomitantes. El 23/05/2017 inicia radioterapia con paclitaxel semanal (80 mg/m2). Evolución Hasta el momento, la paciente lleva 4 semanas de tratamiento con muy buena tolerancia y sin toxicidad relevante. Las lesiones cutáneas se encuentran en remisión, no siendo visibles en la actualidad.
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[ "MORFOLOGIA_NEOPLASIA" ]
angiosarcomas is a MORFOLOGIA_NEOPLASIA, neoplasias is a MORFOLOGIA_NEOPLASIA, adenocarcinoma is a MORFOLOGIA_NEOPLASIA, pT2aN0M0 is a MORFOLOGIA_NEOPLASIA, angiosarcoma is a MORFOLOGIA_NEOPLASIA, metastásica is a MORFOLOGIA_NEOPLASIA, tumoración is a MORFOLOGIA_NEOPLASIA, angiosarcoma moderadamente diferenciado is a MORFOLOGIA_NEOPLASIA, angiosarcoma is a MORFOLOGIA_NEOPLASIA, enfermedad a distancia is a MORFOLOGIA_NEOPLASIA
913_task1
Sentence: Anamnesis Los angiosarcomas cutáneos son neoplasias raras que fundamentalmente se diagnostican en cuero cabelludo y región facial en personas con avanzada edad. También pueden desarrollarse en áreas de linfedema crónico secundario a mastectomía radical, denominándose en este caso "Síndrome de Stewart-Treves", y en regiones que han sido irradiadas como parte de tratamientos complementarios. Presentamos el caso de una paciente de 72 años en la actualidad, natural de Elche, diagnosticada en 2012 de un adenocarcinoma de endocérvix pT2aN0M0. Como tratamiento, se realizó una histerectomía radical con linfadenectomía pélvica tipo Werthein-Meigs en abril de 2012, y posteriormente recibió tratamiento con radioterapia (sobre lecho + margen, cadenas ganglionares regionales y tercio superior de vagina) y quimioterapia (cisplatino 40 mg/m2/semanal) concomitantes durante 6 semanas, seguido de braquiterapia endovaginal que finalizó en agosto de 2012. Como otros antecedentes personales de interés, presentaba una insuficiencia venosa crónica en miembros inferiores y una linfedema en miembro inferior izquierdo residual tras cirugía. Continúa seguimientos periódicos en consultas externas, con controles analíticos e iconográficos que son repetidamente normales, hasta noviembre de 2016, cuando refiere notar en fosa iliaca izquierda, en la cicatriz donde se insertó en 2012 un drenaje abdominal posquirúrgico, una erupción violácea que la paciente relacionaba con una posible picadura de insecto. Exploración física IK 90. Buen estado general, consciente y orientada en tiempo, espacio y persona. Normonutrida y normocoloreada. Eupneica en reposo sin oxígeno suplementario. AC: rítmica, sin soplos. AP: murmullo vesicular conservado. No se auscultan ruidos sobreañadidos. Abdomen: se observa en fosa iliaca izquierda una placa indurada eritematoviolácea de aparición progresiva, con componente vascular y que no blanquea a la digitopresión. No tiene orificios de entrada. No hay dolor a la palpación profunda. No se palpan masas o megalias. Miembros inferiores: linfedema crónica en miembro inferior izquierdo y signos de insuficiencia venosa crónica. Neurológico: exploración básica dentro de la normalidad. Pruebas complementarias Dadas las características de la lesión cutánea, se deriva de forma preferente a Dermatología, quienes realizan biopsia de la lesión. Posteriormente, se solicita un estudio de extensión con TC de tórax, abdomen y pelvis. Diagnóstico El diagnóstico patológico es finalmente compatible con angiosarcoma cutáneo, CD 34 y CD 31 +, Ki 67 > 20 %. En el estudio de extensión, no se identifican nódulos o masas ni adenopatías patológicas en las regiones inguinales, ni tampoco hay evidencia de afectación ganglionar o metastásica a distancia. Tratamiento Fue derivada a la Unidad de Tumores Musculoesqueléticos de referencia en diciembre de 2016, realizándose el 21/03/2017 una exéresis ampliada de la tumoración en zona inguinal izquierda. La anatomía patológica informa de un angiosarcoma moderadamente diferenciado, con márgenes quirúrgicos libres de enfermedad. No obstante, cuando la paciente acude a consultas externas de Oncología Médica tras su intervención, se constata nueva aparición de lesiones cutáneas de características similares en fosa iliaca derecha y muslo derecho. Se realiza biopsia que confirma de nuevo el diagnóstico de angiosarcoma, y se solicita un estudio de extensión que no muestra diseminación locorregional o enfermedad a distancia. Se propone tratamiento con radioterapia y quimioterapia concomitantes. El 23/05/2017 inicia radioterapia con paclitaxel semanal (80 mg/m2). Evolución Hasta el momento, la paciente lleva 4 semanas de tratamiento con muy buena tolerancia y sin toxicidad relevante. Las lesiones cutáneas se encuentran en remisión, no siendo visibles en la actualidad. Instructions: please typing these entity words according to sentence: angiosarcomas, neoplasias, adenocarcinoma, pT2aN0M0, angiosarcoma, metastásica, tumoración, angiosarcoma moderadamente diferenciado, angiosarcoma, enfermedad a distancia Options: MORFOLOGIA_NEOPLASIA
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Anamnesis Los angiosarcomas cutáneos son neoplasias raras que fundamentalmente se diagnostican en cuero cabelludo y región facial en personas con avanzada edad. También pueden desarrollarse en áreas de linfedema crónico secundario a mastectomía radical, denominándose en este caso "Síndrome de Stewart-Treves", y en regiones que han sido irradiadas como parte de tratamientos complementarios. Presentamos el caso de una paciente de 72 años en la actualidad, natural de Elche, diagnosticada en 2012 de un adenocarcinoma de endocérvix pT2aN0M0. Como tratamiento, se realizó una histerectomía radical con linfadenectomía pélvica tipo Werthein-Meigs en abril de 2012, y posteriormente recibió tratamiento con radioterapia (sobre lecho + margen, cadenas ganglionares regionales y tercio superior de vagina) y quimioterapia (cisplatino 40 mg/m2/semanal) concomitantes durante 6 semanas, seguido de braquiterapia endovaginal que finalizó en agosto de 2012. Como otros antecedentes personales de interés, presentaba una insuficiencia venosa crónica en miembros inferiores y una linfedema en miembro inferior izquierdo residual tras cirugía. Continúa seguimientos periódicos en consultas externas, con controles analíticos e iconográficos que son repetidamente normales, hasta noviembre de 2016, cuando refiere notar en fosa iliaca izquierda, en la cicatriz donde se insertó en 2012 un drenaje abdominal posquirúrgico, una erupción violácea que la paciente relacionaba con una posible picadura de insecto. Exploración física IK 90. Buen estado general, consciente y orientada en tiempo, espacio y persona. Normonutrida y normocoloreada. Eupneica en reposo sin oxígeno suplementario. AC: rítmica, sin soplos. AP: murmullo vesicular conservado. No se auscultan ruidos sobreañadidos. Abdomen: se observa en fosa iliaca izquierda una placa indurada eritematoviolácea de aparición progresiva, con componente vascular y que no blanquea a la digitopresión. No tiene orificios de entrada. No hay dolor a la palpación profunda. No se palpan masas o megalias. Miembros inferiores: linfedema crónica en miembro inferior izquierdo y signos de insuficiencia venosa crónica. Neurológico: exploración básica dentro de la normalidad. Pruebas complementarias Dadas las características de la lesión cutánea, se deriva de forma preferente a Dermatología, quienes realizan biopsia de la lesión. Posteriormente, se solicita un estudio de extensión con TC de tórax, abdomen y pelvis. Diagnóstico El diagnóstico patológico es finalmente compatible con angiosarcoma cutáneo, CD 34 y CD 31 +, Ki 67 > 20 %. En el estudio de extensión, no se identifican nódulos o masas ni adenopatías patológicas en las regiones inguinales, ni tampoco hay evidencia de afectación ganglionar o metastásica a distancia. Tratamiento Fue derivada a la Unidad de Tumores Musculoesqueléticos de referencia en diciembre de 2016, realizándose el 21/03/2017 una exéresis ampliada de la tumoración en zona inguinal izquierda. La anatomía patológica informa de un angiosarcoma moderadamente diferenciado, con márgenes quirúrgicos libres de enfermedad. No obstante, cuando la paciente acude a consultas externas de Oncología Médica tras su intervención, se constata nueva aparición de lesiones cutáneas de características similares en fosa iliaca derecha y muslo derecho. Se realiza biopsia que confirma de nuevo el diagnóstico de angiosarcoma, y se solicita un estudio de extensión que no muestra diseminación locorregional o enfermedad a distancia. Se propone tratamiento con radioterapia y quimioterapia concomitantes. El 23/05/2017 inicia radioterapia con paclitaxel semanal (80 mg/m2). Evolución Hasta el momento, la paciente lleva 4 semanas de tratamiento con muy buena tolerancia y sin toxicidad relevante. Las lesiones cutáneas se encuentran en remisión, no siendo visibles en la actualidad.
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[ "MORFOLOGIA_NEOPLASIA" ]
angiosarcomas, neoplasias, adenocarcinoma, pT2aN0M0, angiosarcoma, metastásica, tumoración, angiosarcoma moderadamente diferenciado, angiosarcoma, enfermedad a distancia
913_task2
Sentence: Anamnesis Los angiosarcomas cutáneos son neoplasias raras que fundamentalmente se diagnostican en cuero cabelludo y región facial en personas con avanzada edad. También pueden desarrollarse en áreas de linfedema crónico secundario a mastectomía radical, denominándose en este caso "Síndrome de Stewart-Treves", y en regiones que han sido irradiadas como parte de tratamientos complementarios. Presentamos el caso de una paciente de 72 años en la actualidad, natural de Elche, diagnosticada en 2012 de un adenocarcinoma de endocérvix pT2aN0M0. Como tratamiento, se realizó una histerectomía radical con linfadenectomía pélvica tipo Werthein-Meigs en abril de 2012, y posteriormente recibió tratamiento con radioterapia (sobre lecho + margen, cadenas ganglionares regionales y tercio superior de vagina) y quimioterapia (cisplatino 40 mg/m2/semanal) concomitantes durante 6 semanas, seguido de braquiterapia endovaginal que finalizó en agosto de 2012. Como otros antecedentes personales de interés, presentaba una insuficiencia venosa crónica en miembros inferiores y una linfedema en miembro inferior izquierdo residual tras cirugía. Continúa seguimientos periódicos en consultas externas, con controles analíticos e iconográficos que son repetidamente normales, hasta noviembre de 2016, cuando refiere notar en fosa iliaca izquierda, en la cicatriz donde se insertó en 2012 un drenaje abdominal posquirúrgico, una erupción violácea que la paciente relacionaba con una posible picadura de insecto. Exploración física IK 90. Buen estado general, consciente y orientada en tiempo, espacio y persona. Normonutrida y normocoloreada. Eupneica en reposo sin oxígeno suplementario. AC: rítmica, sin soplos. AP: murmullo vesicular conservado. No se auscultan ruidos sobreañadidos. Abdomen: se observa en fosa iliaca izquierda una placa indurada eritematoviolácea de aparición progresiva, con componente vascular y que no blanquea a la digitopresión. No tiene orificios de entrada. No hay dolor a la palpación profunda. No se palpan masas o megalias. Miembros inferiores: linfedema crónica en miembro inferior izquierdo y signos de insuficiencia venosa crónica. Neurológico: exploración básica dentro de la normalidad. Pruebas complementarias Dadas las características de la lesión cutánea, se deriva de forma preferente a Dermatología, quienes realizan biopsia de la lesión. Posteriormente, se solicita un estudio de extensión con TC de tórax, abdomen y pelvis. Diagnóstico El diagnóstico patológico es finalmente compatible con angiosarcoma cutáneo, CD 34 y CD 31 +, Ki 67 > 20 %. En el estudio de extensión, no se identifican nódulos o masas ni adenopatías patológicas en las regiones inguinales, ni tampoco hay evidencia de afectación ganglionar o metastásica a distancia. Tratamiento Fue derivada a la Unidad de Tumores Musculoesqueléticos de referencia en diciembre de 2016, realizándose el 21/03/2017 una exéresis ampliada de la tumoración en zona inguinal izquierda. La anatomía patológica informa de un angiosarcoma moderadamente diferenciado, con márgenes quirúrgicos libres de enfermedad. No obstante, cuando la paciente acude a consultas externas de Oncología Médica tras su intervención, se constata nueva aparición de lesiones cutáneas de características similares en fosa iliaca derecha y muslo derecho. Se realiza biopsia que confirma de nuevo el diagnóstico de angiosarcoma, y se solicita un estudio de extensión que no muestra diseminación locorregional o enfermedad a distancia. Se propone tratamiento con radioterapia y quimioterapia concomitantes. El 23/05/2017 inicia radioterapia con paclitaxel semanal (80 mg/m2). Evolución Hasta el momento, la paciente lleva 4 semanas de tratamiento con muy buena tolerancia y sin toxicidad relevante. Las lesiones cutáneas se encuentran en remisión, no siendo visibles en la actualidad. Instructions: please extract entity words from the input sentence
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Anamnesis Los angiosarcomas cutáneos son neoplasias raras que fundamentalmente se diagnostican en cuero cabelludo y región facial en personas con avanzada edad. También pueden desarrollarse en áreas de linfedema crónico secundario a mastectomía radical, denominándose en este caso "Síndrome de Stewart-Treves", y en regiones que han sido irradiadas como parte de tratamientos complementarios. Presentamos el caso de una paciente de 72 años en la actualidad, natural de Elche, diagnosticada en 2012 de un adenocarcinoma de endocérvix pT2aN0M0. Como tratamiento, se realizó una histerectomía radical con linfadenectomía pélvica tipo Werthein-Meigs en abril de 2012, y posteriormente recibió tratamiento con radioterapia (sobre lecho + margen, cadenas ganglionares regionales y tercio superior de vagina) y quimioterapia (cisplatino 40 mg/m2/semanal) concomitantes durante 6 semanas, seguido de braquiterapia endovaginal que finalizó en agosto de 2012. Como otros antecedentes personales de interés, presentaba una insuficiencia venosa crónica en miembros inferiores y una linfedema en miembro inferior izquierdo residual tras cirugía. Continúa seguimientos periódicos en consultas externas, con controles analíticos e iconográficos que son repetidamente normales, hasta noviembre de 2016, cuando refiere notar en fosa iliaca izquierda, en la cicatriz donde se insertó en 2012 un drenaje abdominal posquirúrgico, una erupción violácea que la paciente relacionaba con una posible picadura de insecto. Exploración física IK 90. Buen estado general, consciente y orientada en tiempo, espacio y persona. Normonutrida y normocoloreada. Eupneica en reposo sin oxígeno suplementario. AC: rítmica, sin soplos. AP: murmullo vesicular conservado. No se auscultan ruidos sobreañadidos. Abdomen: se observa en fosa iliaca izquierda una placa indurada eritematoviolácea de aparición progresiva, con componente vascular y que no blanquea a la digitopresión. No tiene orificios de entrada. No hay dolor a la palpación profunda. No se palpan masas o megalias. Miembros inferiores: linfedema crónica en miembro inferior izquierdo y signos de insuficiencia venosa crónica. Neurológico: exploración básica dentro de la normalidad. Pruebas complementarias Dadas las características de la lesión cutánea, se deriva de forma preferente a Dermatología, quienes realizan biopsia de la lesión. Posteriormente, se solicita un estudio de extensión con TC de tórax, abdomen y pelvis. Diagnóstico El diagnóstico patológico es finalmente compatible con angiosarcoma cutáneo, CD 34 y CD 31 +, Ki 67 > 20 %. En el estudio de extensión, no se identifican nódulos o masas ni adenopatías patológicas en las regiones inguinales, ni tampoco hay evidencia de afectación ganglionar o metastásica a distancia. Tratamiento Fue derivada a la Unidad de Tumores Musculoesqueléticos de referencia en diciembre de 2016, realizándose el 21/03/2017 una exéresis ampliada de la tumoración en zona inguinal izquierda. La anatomía patológica informa de un angiosarcoma moderadamente diferenciado, con márgenes quirúrgicos libres de enfermedad. No obstante, cuando la paciente acude a consultas externas de Oncología Médica tras su intervención, se constata nueva aparición de lesiones cutáneas de características similares en fosa iliaca derecha y muslo derecho. Se realiza biopsia que confirma de nuevo el diagnóstico de angiosarcoma, y se solicita un estudio de extensión que no muestra diseminación locorregional o enfermedad a distancia. Se propone tratamiento con radioterapia y quimioterapia concomitantes. El 23/05/2017 inicia radioterapia con paclitaxel semanal (80 mg/m2). Evolución Hasta el momento, la paciente lleva 4 semanas de tratamiento con muy buena tolerancia y sin toxicidad relevante. Las lesiones cutáneas se encuentran en remisión, no siendo visibles en la actualidad.
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[ "MORFOLOGIA_NEOPLASIA" ]
Kindern is an umlsterm, Praevalenz is an umlsterm, Uebergewicht is an umlsterm, Adipositas is an umlsterm
MonatsschriftKinderheilkunde.81461192.ger.abstr_task0
Sentence: Fragestellung/Hintergrund : Es wurden Veraenderungen des Body-mass-Index ( BMI ) bei Kindern in den letzten 20 Jahren untersucht und die Praevalenz von Uebergewicht und Adipositas bestimmt . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Fragestellung/Hintergrund : Es wurden Veraenderungen des Body-mass-Index ( BMI ) bei Kindern in den letzten 20 Jahren untersucht und die Praevalenz von Uebergewicht und Adipositas bestimmt .
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[ "umlsterm" ]
Kindern is an umlsterm, Praevalenz is an umlsterm, Uebergewicht is an umlsterm, Adipositas is an umlsterm
MonatsschriftKinderheilkunde.81461192.ger.abstr_task1
Sentence: Fragestellung/Hintergrund : Es wurden Veraenderungen des Body-mass-Index ( BMI ) bei Kindern in den letzten 20 Jahren untersucht und die Praevalenz von Uebergewicht und Adipositas bestimmt . Instructions: please typing these entity words according to sentence: Kindern, Praevalenz, Uebergewicht, Adipositas Options: umlsterm
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Fragestellung/Hintergrund : Es wurden Veraenderungen des Body-mass-Index ( BMI ) bei Kindern in den letzten 20 Jahren untersucht und die Praevalenz von Uebergewicht und Adipositas bestimmt .
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[ "umlsterm" ]
Kindern, Praevalenz, Uebergewicht, Adipositas
MonatsschriftKinderheilkunde.81461192.ger.abstr_task2
Sentence: Fragestellung/Hintergrund : Es wurden Veraenderungen des Body-mass-Index ( BMI ) bei Kindern in den letzten 20 Jahren untersucht und die Praevalenz von Uebergewicht und Adipositas bestimmt . Instructions: please extract entity words from the input sentence
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Fragestellung/Hintergrund : Es wurden Veraenderungen des Body-mass-Index ( BMI ) bei Kindern in den letzten 20 Jahren untersucht und die Praevalenz von Uebergewicht und Adipositas bestimmt .
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[ "umlsterm" ]
androgen is a CHEMICAL, Androgens is a CHEMICAL, androgens is a CHEMICAL, testosterone is a CHEMICAL, 5alpha - dihydrotestosterone is a CHEMICAL, DHT is a CHEMICAL, androgen receptor is a GENE-Y, nuclear receptors is a GENE-N, androgen receptor is a GENE-Y, nuclear receptors is a GENE-N, nuclear receptor is a GENE-N, androgens is a CHEMICAL, androgens is a CHEMICAL
826_task0
Sentence: Complexities of androgen action. Androgens mediate a wide range of processes during embryogenesis and in the adult. In mammals, the principal androgens are testosterone and its 5alpha-reduced metabolite, 5alpha-dihydrotestosterone (DHT). Although these androgenic hormones are diverse in character, it is believed that their effects are mediated via the protein products of a single androgen receptor gene encoded on the X-chromosome. A great deal of information has now accumulated pertaining to the mechanisms by which nuclear receptors, such as the androgen receptor, modulate the activity of responsive genes. The studies have demonstrated the participation of a number of ancillary proteins in modulating activation or repression by nuclear receptors. In addition to studies focused on the mechanisms of nuclear receptor function, additional work has illuminated the mechanism by which androgens are metabolized in selected tissues. This information provides a perspective on the number of levels of complexity by which differential gene regulation by androgens may occur in different tissues and in different cell types. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N, GENE-Y, CHEMICAL
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Complexities of androgen action. Androgens mediate a wide range of processes during embryogenesis and in the adult. In mammals, the principal androgens are testosterone and its 5alpha-reduced metabolite, 5alpha-dihydrotestosterone (DHT). Although these androgenic hormones are diverse in character, it is believed that their effects are mediated via the protein products of a single androgen receptor gene encoded on the X-chromosome. A great deal of information has now accumulated pertaining to the mechanisms by which nuclear receptors, such as the androgen receptor, modulate the activity of responsive genes. The studies have demonstrated the participation of a number of ancillary proteins in modulating activation or repression by nuclear receptors. In addition to studies focused on the mechanisms of nuclear receptor function, additional work has illuminated the mechanism by which androgens are metabolized in selected tissues. This information provides a perspective on the number of levels of complexity by which differential gene regulation by androgens may occur in different tissues and in different cell types.
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[ "CHEMICAL", "GENE-Y", "GENE-N" ]
androgen is a CHEMICAL, Androgens is a CHEMICAL, androgens is a CHEMICAL, testosterone is a CHEMICAL, 5alpha - dihydrotestosterone is a CHEMICAL, DHT is a CHEMICAL, androgen receptor is a GENE-Y, nuclear receptors is a GENE-N, androgen receptor is a GENE-Y, nuclear receptors is a GENE-N, nuclear receptor is a GENE-N, androgens is a CHEMICAL, androgens is a CHEMICAL
826_task1
Sentence: Complexities of androgen action. Androgens mediate a wide range of processes during embryogenesis and in the adult. In mammals, the principal androgens are testosterone and its 5alpha-reduced metabolite, 5alpha-dihydrotestosterone (DHT). Although these androgenic hormones are diverse in character, it is believed that their effects are mediated via the protein products of a single androgen receptor gene encoded on the X-chromosome. A great deal of information has now accumulated pertaining to the mechanisms by which nuclear receptors, such as the androgen receptor, modulate the activity of responsive genes. The studies have demonstrated the participation of a number of ancillary proteins in modulating activation or repression by nuclear receptors. In addition to studies focused on the mechanisms of nuclear receptor function, additional work has illuminated the mechanism by which androgens are metabolized in selected tissues. This information provides a perspective on the number of levels of complexity by which differential gene regulation by androgens may occur in different tissues and in different cell types. Instructions: please typing these entity words according to sentence: androgen, Androgens, androgens, testosterone, 5alpha - dihydrotestosterone, DHT, androgen receptor, nuclear receptors, androgen receptor, nuclear receptors, nuclear receptor, androgens, androgens Options: GENE-N, GENE-Y, CHEMICAL
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Complexities of androgen action. Androgens mediate a wide range of processes during embryogenesis and in the adult. In mammals, the principal androgens are testosterone and its 5alpha-reduced metabolite, 5alpha-dihydrotestosterone (DHT). Although these androgenic hormones are diverse in character, it is believed that their effects are mediated via the protein products of a single androgen receptor gene encoded on the X-chromosome. A great deal of information has now accumulated pertaining to the mechanisms by which nuclear receptors, such as the androgen receptor, modulate the activity of responsive genes. The studies have demonstrated the participation of a number of ancillary proteins in modulating activation or repression by nuclear receptors. In addition to studies focused on the mechanisms of nuclear receptor function, additional work has illuminated the mechanism by which androgens are metabolized in selected tissues. This information provides a perspective on the number of levels of complexity by which differential gene regulation by androgens may occur in different tissues and in different cell types.
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[ "CHEMICAL", "GENE-Y", "GENE-N" ]
androgen, Androgens, androgens, testosterone, 5alpha - dihydrotestosterone, DHT, androgen receptor, nuclear receptors, androgen receptor, nuclear receptors, nuclear receptor, androgens, androgens
826_task2
Sentence: Complexities of androgen action. Androgens mediate a wide range of processes during embryogenesis and in the adult. In mammals, the principal androgens are testosterone and its 5alpha-reduced metabolite, 5alpha-dihydrotestosterone (DHT). Although these androgenic hormones are diverse in character, it is believed that their effects are mediated via the protein products of a single androgen receptor gene encoded on the X-chromosome. A great deal of information has now accumulated pertaining to the mechanisms by which nuclear receptors, such as the androgen receptor, modulate the activity of responsive genes. The studies have demonstrated the participation of a number of ancillary proteins in modulating activation or repression by nuclear receptors. In addition to studies focused on the mechanisms of nuclear receptor function, additional work has illuminated the mechanism by which androgens are metabolized in selected tissues. This information provides a perspective on the number of levels of complexity by which differential gene regulation by androgens may occur in different tissues and in different cell types. Instructions: please extract entity words from the input sentence
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Complexities of androgen action. Androgens mediate a wide range of processes during embryogenesis and in the adult. In mammals, the principal androgens are testosterone and its 5alpha-reduced metabolite, 5alpha-dihydrotestosterone (DHT). Although these androgenic hormones are diverse in character, it is believed that their effects are mediated via the protein products of a single androgen receptor gene encoded on the X-chromosome. A great deal of information has now accumulated pertaining to the mechanisms by which nuclear receptors, such as the androgen receptor, modulate the activity of responsive genes. The studies have demonstrated the participation of a number of ancillary proteins in modulating activation or repression by nuclear receptors. In addition to studies focused on the mechanisms of nuclear receptor function, additional work has illuminated the mechanism by which androgens are metabolized in selected tissues. This information provides a perspective on the number of levels of complexity by which differential gene regulation by androgens may occur in different tissues and in different cell types.
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[ "CHEMICAL", "GENE-Y", "GENE-N" ]
alfa - feto proteína is a PROTEINAS, beta - hCG is a PROTEINAS, carboplatino is a NORMALIZABLES
27_task0
Sentence: Paciente varón de 29 años. Es remitido a nuestro servicio para completar estudio porque, tras cuadro de aparición de tumoración indolora en su testículo izquierdo de un mes de evolución, se le detecta en la ecografía un testículo izquierdo hipogénico y disminuido de tamaño, y un testículo derecho con parénquima heterogéneo sospechoso de neoplasia. No presenta otra sintomatología urológica, no astenia, no pérdida de peso. Tampoco tiene antecedentes personales de interés. En la exploración física se palpa un teste izquierdo hipotrófico, y un teste derecho algo aumentado de tamaño. Ambos no dolorosos, de consistencia normales y de superficie regulares. Epidídimos y cordones sin hallazgos patológicos. En las determinaciones analíticas destaca una hemostasia, bioquímica y hemograma dentro de los parámetros correspondientes a la normalidad, y una alfa-feto proteína de 2.7ng/ml con una beta-hCG de 4.2mUI/ml. Durante el ingreso se realiza nueva ecografía con flujo Doppler y se aprecia: un teste derecho de 49mm x 36mm x 26mm con lesión hipoecoica, de bordes lobulados, heterogénea, que ocupa prácticamente todo el testículo, y que presenta aumento del flujo Doppler. Y un teste izquierdo de 32mm x 22mm x 20mm hetrogéneo con lesión focal ligeramente hipoecoica de aproximadamente 9mm con sutil flujo Doppler. Además, microlitiasis testiculares bilaterales. Se le realizó también una Radiografía de tórax, en la que no se apreció ningún hallazgo patológico, y un TAC toraco-abdomino-pélvico con contraste, donde no se identificaron adenopatías ni metástasis en ninguno de los territorios visualizados. Con el diagnóstico de tumor testicular bilateral, se le realizó una orquiectomía bilateral vía inguinal y se la pautó tratamiento hormonal sustitutivo. En la anatomía patológica informan de: testículo izquierdo atrófico con múltiples focos microscópicos de seminoma clásico asociado a amplias áreas de neoplasia intratubular de células germinales (NICG) con ausencia de infiltración tumoral en albugínea, rete testis, epidídimo o infiltración vascular. El testículo derecho presenta tumoración con características de seminoma clásico que ocupa prácticamente todo el parénquima, asociado a focos de neoplasia intratubular de células germinales (NICG) y focos de atrofia en el testículo restante. Túnica albugínea, rete testis, epidídimo y borde quirúrgico libres de tumor. El tratamiento se completó con dos ciclos de quimioterapia con carboplatino según protocolo del hospital. Actualmente lleva más de tres años en remisión completa de la enfermedad. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: NORMALIZABLES, PROTEINAS
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Paciente varón de 29 años. Es remitido a nuestro servicio para completar estudio porque, tras cuadro de aparición de tumoración indolora en su testículo izquierdo de un mes de evolución, se le detecta en la ecografía un testículo izquierdo hipogénico y disminuido de tamaño, y un testículo derecho con parénquima heterogéneo sospechoso de neoplasia. No presenta otra sintomatología urológica, no astenia, no pérdida de peso. Tampoco tiene antecedentes personales de interés. En la exploración física se palpa un teste izquierdo hipotrófico, y un teste derecho algo aumentado de tamaño. Ambos no dolorosos, de consistencia normales y de superficie regulares. Epidídimos y cordones sin hallazgos patológicos. En las determinaciones analíticas destaca una hemostasia, bioquímica y hemograma dentro de los parámetros correspondientes a la normalidad, y una alfa-feto proteína de 2.7ng/ml con una beta-hCG de 4.2mUI/ml. Durante el ingreso se realiza nueva ecografía con flujo Doppler y se aprecia: un teste derecho de 49mm x 36mm x 26mm con lesión hipoecoica, de bordes lobulados, heterogénea, que ocupa prácticamente todo el testículo, y que presenta aumento del flujo Doppler. Y un teste izquierdo de 32mm x 22mm x 20mm hetrogéneo con lesión focal ligeramente hipoecoica de aproximadamente 9mm con sutil flujo Doppler. Además, microlitiasis testiculares bilaterales. Se le realizó también una Radiografía de tórax, en la que no se apreció ningún hallazgo patológico, y un TAC toraco-abdomino-pélvico con contraste, donde no se identificaron adenopatías ni metástasis en ninguno de los territorios visualizados. Con el diagnóstico de tumor testicular bilateral, se le realizó una orquiectomía bilateral vía inguinal y se la pautó tratamiento hormonal sustitutivo. En la anatomía patológica informan de: testículo izquierdo atrófico con múltiples focos microscópicos de seminoma clásico asociado a amplias áreas de neoplasia intratubular de células germinales (NICG) con ausencia de infiltración tumoral en albugínea, rete testis, epidídimo o infiltración vascular. El testículo derecho presenta tumoración con características de seminoma clásico que ocupa prácticamente todo el parénquima, asociado a focos de neoplasia intratubular de células germinales (NICG) y focos de atrofia en el testículo restante. Túnica albugínea, rete testis, epidídimo y borde quirúrgico libres de tumor. El tratamiento se completó con dos ciclos de quimioterapia con carboplatino según protocolo del hospital. Actualmente lleva más de tres años en remisión completa de la enfermedad.
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[ "PROTEINAS", "NORMALIZABLES" ]
alfa - feto proteína is a PROTEINAS, beta - hCG is a PROTEINAS, carboplatino is a NORMALIZABLES
27_task1
Sentence: Paciente varón de 29 años. Es remitido a nuestro servicio para completar estudio porque, tras cuadro de aparición de tumoración indolora en su testículo izquierdo de un mes de evolución, se le detecta en la ecografía un testículo izquierdo hipogénico y disminuido de tamaño, y un testículo derecho con parénquima heterogéneo sospechoso de neoplasia. No presenta otra sintomatología urológica, no astenia, no pérdida de peso. Tampoco tiene antecedentes personales de interés. En la exploración física se palpa un teste izquierdo hipotrófico, y un teste derecho algo aumentado de tamaño. Ambos no dolorosos, de consistencia normales y de superficie regulares. Epidídimos y cordones sin hallazgos patológicos. En las determinaciones analíticas destaca una hemostasia, bioquímica y hemograma dentro de los parámetros correspondientes a la normalidad, y una alfa-feto proteína de 2.7ng/ml con una beta-hCG de 4.2mUI/ml. Durante el ingreso se realiza nueva ecografía con flujo Doppler y se aprecia: un teste derecho de 49mm x 36mm x 26mm con lesión hipoecoica, de bordes lobulados, heterogénea, que ocupa prácticamente todo el testículo, y que presenta aumento del flujo Doppler. Y un teste izquierdo de 32mm x 22mm x 20mm hetrogéneo con lesión focal ligeramente hipoecoica de aproximadamente 9mm con sutil flujo Doppler. Además, microlitiasis testiculares bilaterales. Se le realizó también una Radiografía de tórax, en la que no se apreció ningún hallazgo patológico, y un TAC toraco-abdomino-pélvico con contraste, donde no se identificaron adenopatías ni metástasis en ninguno de los territorios visualizados. Con el diagnóstico de tumor testicular bilateral, se le realizó una orquiectomía bilateral vía inguinal y se la pautó tratamiento hormonal sustitutivo. En la anatomía patológica informan de: testículo izquierdo atrófico con múltiples focos microscópicos de seminoma clásico asociado a amplias áreas de neoplasia intratubular de células germinales (NICG) con ausencia de infiltración tumoral en albugínea, rete testis, epidídimo o infiltración vascular. El testículo derecho presenta tumoración con características de seminoma clásico que ocupa prácticamente todo el parénquima, asociado a focos de neoplasia intratubular de células germinales (NICG) y focos de atrofia en el testículo restante. Túnica albugínea, rete testis, epidídimo y borde quirúrgico libres de tumor. El tratamiento se completó con dos ciclos de quimioterapia con carboplatino según protocolo del hospital. Actualmente lleva más de tres años en remisión completa de la enfermedad. Instructions: please typing these entity words according to sentence: alfa - feto proteína, beta - hCG, carboplatino Options: NORMALIZABLES, PROTEINAS
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Paciente varón de 29 años. Es remitido a nuestro servicio para completar estudio porque, tras cuadro de aparición de tumoración indolora en su testículo izquierdo de un mes de evolución, se le detecta en la ecografía un testículo izquierdo hipogénico y disminuido de tamaño, y un testículo derecho con parénquima heterogéneo sospechoso de neoplasia. No presenta otra sintomatología urológica, no astenia, no pérdida de peso. Tampoco tiene antecedentes personales de interés. En la exploración física se palpa un teste izquierdo hipotrófico, y un teste derecho algo aumentado de tamaño. Ambos no dolorosos, de consistencia normales y de superficie regulares. Epidídimos y cordones sin hallazgos patológicos. En las determinaciones analíticas destaca una hemostasia, bioquímica y hemograma dentro de los parámetros correspondientes a la normalidad, y una alfa-feto proteína de 2.7ng/ml con una beta-hCG de 4.2mUI/ml. Durante el ingreso se realiza nueva ecografía con flujo Doppler y se aprecia: un teste derecho de 49mm x 36mm x 26mm con lesión hipoecoica, de bordes lobulados, heterogénea, que ocupa prácticamente todo el testículo, y que presenta aumento del flujo Doppler. Y un teste izquierdo de 32mm x 22mm x 20mm hetrogéneo con lesión focal ligeramente hipoecoica de aproximadamente 9mm con sutil flujo Doppler. Además, microlitiasis testiculares bilaterales. Se le realizó también una Radiografía de tórax, en la que no se apreció ningún hallazgo patológico, y un TAC toraco-abdomino-pélvico con contraste, donde no se identificaron adenopatías ni metástasis en ninguno de los territorios visualizados. Con el diagnóstico de tumor testicular bilateral, se le realizó una orquiectomía bilateral vía inguinal y se la pautó tratamiento hormonal sustitutivo. En la anatomía patológica informan de: testículo izquierdo atrófico con múltiples focos microscópicos de seminoma clásico asociado a amplias áreas de neoplasia intratubular de células germinales (NICG) con ausencia de infiltración tumoral en albugínea, rete testis, epidídimo o infiltración vascular. El testículo derecho presenta tumoración con características de seminoma clásico que ocupa prácticamente todo el parénquima, asociado a focos de neoplasia intratubular de células germinales (NICG) y focos de atrofia en el testículo restante. Túnica albugínea, rete testis, epidídimo y borde quirúrgico libres de tumor. El tratamiento se completó con dos ciclos de quimioterapia con carboplatino según protocolo del hospital. Actualmente lleva más de tres años en remisión completa de la enfermedad.
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[ "PROTEINAS", "NORMALIZABLES" ]
alfa - feto proteína, beta - hCG, carboplatino
27_task2
Sentence: Paciente varón de 29 años. Es remitido a nuestro servicio para completar estudio porque, tras cuadro de aparición de tumoración indolora en su testículo izquierdo de un mes de evolución, se le detecta en la ecografía un testículo izquierdo hipogénico y disminuido de tamaño, y un testículo derecho con parénquima heterogéneo sospechoso de neoplasia. No presenta otra sintomatología urológica, no astenia, no pérdida de peso. Tampoco tiene antecedentes personales de interés. En la exploración física se palpa un teste izquierdo hipotrófico, y un teste derecho algo aumentado de tamaño. Ambos no dolorosos, de consistencia normales y de superficie regulares. Epidídimos y cordones sin hallazgos patológicos. En las determinaciones analíticas destaca una hemostasia, bioquímica y hemograma dentro de los parámetros correspondientes a la normalidad, y una alfa-feto proteína de 2.7ng/ml con una beta-hCG de 4.2mUI/ml. Durante el ingreso se realiza nueva ecografía con flujo Doppler y se aprecia: un teste derecho de 49mm x 36mm x 26mm con lesión hipoecoica, de bordes lobulados, heterogénea, que ocupa prácticamente todo el testículo, y que presenta aumento del flujo Doppler. Y un teste izquierdo de 32mm x 22mm x 20mm hetrogéneo con lesión focal ligeramente hipoecoica de aproximadamente 9mm con sutil flujo Doppler. Además, microlitiasis testiculares bilaterales. Se le realizó también una Radiografía de tórax, en la que no se apreció ningún hallazgo patológico, y un TAC toraco-abdomino-pélvico con contraste, donde no se identificaron adenopatías ni metástasis en ninguno de los territorios visualizados. Con el diagnóstico de tumor testicular bilateral, se le realizó una orquiectomía bilateral vía inguinal y se la pautó tratamiento hormonal sustitutivo. En la anatomía patológica informan de: testículo izquierdo atrófico con múltiples focos microscópicos de seminoma clásico asociado a amplias áreas de neoplasia intratubular de células germinales (NICG) con ausencia de infiltración tumoral en albugínea, rete testis, epidídimo o infiltración vascular. El testículo derecho presenta tumoración con características de seminoma clásico que ocupa prácticamente todo el parénquima, asociado a focos de neoplasia intratubular de células germinales (NICG) y focos de atrofia en el testículo restante. Túnica albugínea, rete testis, epidídimo y borde quirúrgico libres de tumor. El tratamiento se completó con dos ciclos de quimioterapia con carboplatino según protocolo del hospital. Actualmente lleva más de tres años en remisión completa de la enfermedad. Instructions: please extract entity words from the input sentence
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Paciente varón de 29 años. Es remitido a nuestro servicio para completar estudio porque, tras cuadro de aparición de tumoración indolora en su testículo izquierdo de un mes de evolución, se le detecta en la ecografía un testículo izquierdo hipogénico y disminuido de tamaño, y un testículo derecho con parénquima heterogéneo sospechoso de neoplasia. No presenta otra sintomatología urológica, no astenia, no pérdida de peso. Tampoco tiene antecedentes personales de interés. En la exploración física se palpa un teste izquierdo hipotrófico, y un teste derecho algo aumentado de tamaño. Ambos no dolorosos, de consistencia normales y de superficie regulares. Epidídimos y cordones sin hallazgos patológicos. En las determinaciones analíticas destaca una hemostasia, bioquímica y hemograma dentro de los parámetros correspondientes a la normalidad, y una alfa-feto proteína de 2.7ng/ml con una beta-hCG de 4.2mUI/ml. Durante el ingreso se realiza nueva ecografía con flujo Doppler y se aprecia: un teste derecho de 49mm x 36mm x 26mm con lesión hipoecoica, de bordes lobulados, heterogénea, que ocupa prácticamente todo el testículo, y que presenta aumento del flujo Doppler. Y un teste izquierdo de 32mm x 22mm x 20mm hetrogéneo con lesión focal ligeramente hipoecoica de aproximadamente 9mm con sutil flujo Doppler. Además, microlitiasis testiculares bilaterales. Se le realizó también una Radiografía de tórax, en la que no se apreció ningún hallazgo patológico, y un TAC toraco-abdomino-pélvico con contraste, donde no se identificaron adenopatías ni metástasis en ninguno de los territorios visualizados. Con el diagnóstico de tumor testicular bilateral, se le realizó una orquiectomía bilateral vía inguinal y se la pautó tratamiento hormonal sustitutivo. En la anatomía patológica informan de: testículo izquierdo atrófico con múltiples focos microscópicos de seminoma clásico asociado a amplias áreas de neoplasia intratubular de células germinales (NICG) con ausencia de infiltración tumoral en albugínea, rete testis, epidídimo o infiltración vascular. El testículo derecho presenta tumoración con características de seminoma clásico que ocupa prácticamente todo el parénquima, asociado a focos de neoplasia intratubular de células germinales (NICG) y focos de atrofia en el testículo restante. Túnica albugínea, rete testis, epidídimo y borde quirúrgico libres de tumor. El tratamiento se completó con dos ciclos de quimioterapia con carboplatino según protocolo del hospital. Actualmente lleva más de tres años en remisión completa de la enfermedad.
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[ "PROTEINAS", "NORMALIZABLES" ]
Luftembolien is an umlsterm, Echokardiographie is an umlsterm, TEE is an umlsterm, Atemdruck is an umlsterm, Kontrast - TEE is an umlsterm, Atemhubvolumen is an umlsterm, Patienten is an umlsterm, Standardeinstellung is an umlsterm, TEE is an umlsterm, Kontrastmittels is an umlsterm, Injektion is an umlsterm, Kontrastmittels is an umlsterm, Druck is an umlsterm, Injektion is an umlsterm, Kontrastmittels is an umlsterm, PEEP is an umlsterm, Atemhubvolumen is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Atemhubvolumen is an umlsterm, Kontrast - TEE is an umlsterm
DerAnaesthesist.60450235.ger.abstr_task0
Sentence: Paradoxe Luftembolien sind trotz praeoperativem Ausschluss eines offenen Foramen ovale PFO ) ( mittels transoesophagealer Echokardiographie ( TEE ) unter Durchfuehrung eines Ventilationsmanoevers mit einem endinspiratorischen Atemdruck von 20 cm H2O berichtet worden . Es stellt sich die Frage , ob die Empfindlichkeit der Kontrast-TEE unter Ventilationsmanoevern mit PEEP-Beatmung und hohem Atemhubvolumen erhoeht werden kann . Untersucht wurden 80 Patienten der ASARisikogruppen I und II , im Alter von 25 bis 72 Jahren . Der biatriale Blick in der kurzen Achse wurde als Standardeinstellung der TEE verwendet . Die Gabe des Kontrastmittels erfolgte unter zwei verschiedenen Ventilationsmanoevern . Manoever I : Injektion des Kontrastmittels bei einem endinspiratorischen Druck von 20 cmH2O fuer die Dauer von 5 s. Manoever II : Injektion des Kontrastmittels unter Beatmung mit PEEP von 15 cmH2O, bei einem Atemhubvolumen von 1200 ml und einer Atemfrequenz von 6/min. Die Haeufigkeit eines PFO mit Rechts-links-Shunt unter dem Manoever I betrug 8,7% ( 7 Patienten ) , unter dem Manoever II 15% ( 12 Patienten ) . Bei einem weiteren Patienten gelang der Nachweis eines PFO erst intraoperativ ( Zufallsbefund ) . Die Anwendung von Provokationsmanoevern mit PEEP-Beatmung und einem hohem Atemhubvolumen bei der intraoperativen Kontrast-TEE kann moeglicherweise zu einer Erhoehung der Nachweisquote eines PFO mit Rechts-links-Shunt beitragen . Eine 100%ige Sensitivitaet wird hiermit jedoch nicht erreicht falsch negative Befunde , lassen sich nicht ausschliessen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Paradoxe Luftembolien sind trotz praeoperativem Ausschluss eines offenen Foramen ovale PFO ) ( mittels transoesophagealer Echokardiographie ( TEE ) unter Durchfuehrung eines Ventilationsmanoevers mit einem endinspiratorischen Atemdruck von 20 cm H2O berichtet worden . Es stellt sich die Frage , ob die Empfindlichkeit der Kontrast-TEE unter Ventilationsmanoevern mit PEEP-Beatmung und hohem Atemhubvolumen erhoeht werden kann . Untersucht wurden 80 Patienten der ASARisikogruppen I und II , im Alter von 25 bis 72 Jahren . Der biatriale Blick in der kurzen Achse wurde als Standardeinstellung der TEE verwendet . Die Gabe des Kontrastmittels erfolgte unter zwei verschiedenen Ventilationsmanoevern . Manoever I : Injektion des Kontrastmittels bei einem endinspiratorischen Druck von 20 cmH2O fuer die Dauer von 5 s. Manoever II : Injektion des Kontrastmittels unter Beatmung mit PEEP von 15 cmH2O, bei einem Atemhubvolumen von 1200 ml und einer Atemfrequenz von 6/min. Die Haeufigkeit eines PFO mit Rechts-links-Shunt unter dem Manoever I betrug 8,7% ( 7 Patienten ) , unter dem Manoever II 15% ( 12 Patienten ) . Bei einem weiteren Patienten gelang der Nachweis eines PFO erst intraoperativ ( Zufallsbefund ) . Die Anwendung von Provokationsmanoevern mit PEEP-Beatmung und einem hohem Atemhubvolumen bei der intraoperativen Kontrast-TEE kann moeglicherweise zu einer Erhoehung der Nachweisquote eines PFO mit Rechts-links-Shunt beitragen . Eine 100%ige Sensitivitaet wird hiermit jedoch nicht erreicht falsch negative Befunde , lassen sich nicht ausschliessen .
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[ "umlsterm" ]
Luftembolien is an umlsterm, Echokardiographie is an umlsterm, TEE is an umlsterm, Atemdruck is an umlsterm, Kontrast - TEE is an umlsterm, Atemhubvolumen is an umlsterm, Patienten is an umlsterm, Standardeinstellung is an umlsterm, TEE is an umlsterm, Kontrastmittels is an umlsterm, Injektion is an umlsterm, Kontrastmittels is an umlsterm, Druck is an umlsterm, Injektion is an umlsterm, Kontrastmittels is an umlsterm, PEEP is an umlsterm, Atemhubvolumen is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Atemhubvolumen is an umlsterm, Kontrast - TEE is an umlsterm
DerAnaesthesist.60450235.ger.abstr_task1
Sentence: Paradoxe Luftembolien sind trotz praeoperativem Ausschluss eines offenen Foramen ovale PFO ) ( mittels transoesophagealer Echokardiographie ( TEE ) unter Durchfuehrung eines Ventilationsmanoevers mit einem endinspiratorischen Atemdruck von 20 cm H2O berichtet worden . Es stellt sich die Frage , ob die Empfindlichkeit der Kontrast-TEE unter Ventilationsmanoevern mit PEEP-Beatmung und hohem Atemhubvolumen erhoeht werden kann . Untersucht wurden 80 Patienten der ASARisikogruppen I und II , im Alter von 25 bis 72 Jahren . Der biatriale Blick in der kurzen Achse wurde als Standardeinstellung der TEE verwendet . Die Gabe des Kontrastmittels erfolgte unter zwei verschiedenen Ventilationsmanoevern . Manoever I : Injektion des Kontrastmittels bei einem endinspiratorischen Druck von 20 cmH2O fuer die Dauer von 5 s. Manoever II : Injektion des Kontrastmittels unter Beatmung mit PEEP von 15 cmH2O, bei einem Atemhubvolumen von 1200 ml und einer Atemfrequenz von 6/min. Die Haeufigkeit eines PFO mit Rechts-links-Shunt unter dem Manoever I betrug 8,7% ( 7 Patienten ) , unter dem Manoever II 15% ( 12 Patienten ) . Bei einem weiteren Patienten gelang der Nachweis eines PFO erst intraoperativ ( Zufallsbefund ) . Die Anwendung von Provokationsmanoevern mit PEEP-Beatmung und einem hohem Atemhubvolumen bei der intraoperativen Kontrast-TEE kann moeglicherweise zu einer Erhoehung der Nachweisquote eines PFO mit Rechts-links-Shunt beitragen . Eine 100%ige Sensitivitaet wird hiermit jedoch nicht erreicht falsch negative Befunde , lassen sich nicht ausschliessen . Instructions: please typing these entity words according to sentence: Luftembolien, Echokardiographie, TEE, Atemdruck, Kontrast - TEE, Atemhubvolumen, Patienten, Standardeinstellung, TEE, Kontrastmittels, Injektion, Kontrastmittels, Druck, Injektion, Kontrastmittels, PEEP, Atemhubvolumen, Patienten, Patienten, Patienten, Atemhubvolumen, Kontrast - TEE Options: umlsterm
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Paradoxe Luftembolien sind trotz praeoperativem Ausschluss eines offenen Foramen ovale PFO ) ( mittels transoesophagealer Echokardiographie ( TEE ) unter Durchfuehrung eines Ventilationsmanoevers mit einem endinspiratorischen Atemdruck von 20 cm H2O berichtet worden . Es stellt sich die Frage , ob die Empfindlichkeit der Kontrast-TEE unter Ventilationsmanoevern mit PEEP-Beatmung und hohem Atemhubvolumen erhoeht werden kann . Untersucht wurden 80 Patienten der ASARisikogruppen I und II , im Alter von 25 bis 72 Jahren . Der biatriale Blick in der kurzen Achse wurde als Standardeinstellung der TEE verwendet . Die Gabe des Kontrastmittels erfolgte unter zwei verschiedenen Ventilationsmanoevern . Manoever I : Injektion des Kontrastmittels bei einem endinspiratorischen Druck von 20 cmH2O fuer die Dauer von 5 s. Manoever II : Injektion des Kontrastmittels unter Beatmung mit PEEP von 15 cmH2O, bei einem Atemhubvolumen von 1200 ml und einer Atemfrequenz von 6/min. Die Haeufigkeit eines PFO mit Rechts-links-Shunt unter dem Manoever I betrug 8,7% ( 7 Patienten ) , unter dem Manoever II 15% ( 12 Patienten ) . Bei einem weiteren Patienten gelang der Nachweis eines PFO erst intraoperativ ( Zufallsbefund ) . Die Anwendung von Provokationsmanoevern mit PEEP-Beatmung und einem hohem Atemhubvolumen bei der intraoperativen Kontrast-TEE kann moeglicherweise zu einer Erhoehung der Nachweisquote eines PFO mit Rechts-links-Shunt beitragen . Eine 100%ige Sensitivitaet wird hiermit jedoch nicht erreicht falsch negative Befunde , lassen sich nicht ausschliessen .
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[ "umlsterm" ]
Luftembolien, Echokardiographie, TEE, Atemdruck, Kontrast - TEE, Atemhubvolumen, Patienten, Standardeinstellung, TEE, Kontrastmittels, Injektion, Kontrastmittels, Druck, Injektion, Kontrastmittels, PEEP, Atemhubvolumen, Patienten, Patienten, Patienten, Atemhubvolumen, Kontrast - TEE
DerAnaesthesist.60450235.ger.abstr_task2
Sentence: Paradoxe Luftembolien sind trotz praeoperativem Ausschluss eines offenen Foramen ovale PFO ) ( mittels transoesophagealer Echokardiographie ( TEE ) unter Durchfuehrung eines Ventilationsmanoevers mit einem endinspiratorischen Atemdruck von 20 cm H2O berichtet worden . Es stellt sich die Frage , ob die Empfindlichkeit der Kontrast-TEE unter Ventilationsmanoevern mit PEEP-Beatmung und hohem Atemhubvolumen erhoeht werden kann . Untersucht wurden 80 Patienten der ASARisikogruppen I und II , im Alter von 25 bis 72 Jahren . Der biatriale Blick in der kurzen Achse wurde als Standardeinstellung der TEE verwendet . Die Gabe des Kontrastmittels erfolgte unter zwei verschiedenen Ventilationsmanoevern . Manoever I : Injektion des Kontrastmittels bei einem endinspiratorischen Druck von 20 cmH2O fuer die Dauer von 5 s. Manoever II : Injektion des Kontrastmittels unter Beatmung mit PEEP von 15 cmH2O, bei einem Atemhubvolumen von 1200 ml und einer Atemfrequenz von 6/min. Die Haeufigkeit eines PFO mit Rechts-links-Shunt unter dem Manoever I betrug 8,7% ( 7 Patienten ) , unter dem Manoever II 15% ( 12 Patienten ) . Bei einem weiteren Patienten gelang der Nachweis eines PFO erst intraoperativ ( Zufallsbefund ) . Die Anwendung von Provokationsmanoevern mit PEEP-Beatmung und einem hohem Atemhubvolumen bei der intraoperativen Kontrast-TEE kann moeglicherweise zu einer Erhoehung der Nachweisquote eines PFO mit Rechts-links-Shunt beitragen . Eine 100%ige Sensitivitaet wird hiermit jedoch nicht erreicht falsch negative Befunde , lassen sich nicht ausschliessen . Instructions: please extract entity words from the input sentence
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Paradoxe Luftembolien sind trotz praeoperativem Ausschluss eines offenen Foramen ovale PFO ) ( mittels transoesophagealer Echokardiographie ( TEE ) unter Durchfuehrung eines Ventilationsmanoevers mit einem endinspiratorischen Atemdruck von 20 cm H2O berichtet worden . Es stellt sich die Frage , ob die Empfindlichkeit der Kontrast-TEE unter Ventilationsmanoevern mit PEEP-Beatmung und hohem Atemhubvolumen erhoeht werden kann . Untersucht wurden 80 Patienten der ASARisikogruppen I und II , im Alter von 25 bis 72 Jahren . Der biatriale Blick in der kurzen Achse wurde als Standardeinstellung der TEE verwendet . Die Gabe des Kontrastmittels erfolgte unter zwei verschiedenen Ventilationsmanoevern . Manoever I : Injektion des Kontrastmittels bei einem endinspiratorischen Druck von 20 cmH2O fuer die Dauer von 5 s. Manoever II : Injektion des Kontrastmittels unter Beatmung mit PEEP von 15 cmH2O, bei einem Atemhubvolumen von 1200 ml und einer Atemfrequenz von 6/min. Die Haeufigkeit eines PFO mit Rechts-links-Shunt unter dem Manoever I betrug 8,7% ( 7 Patienten ) , unter dem Manoever II 15% ( 12 Patienten ) . Bei einem weiteren Patienten gelang der Nachweis eines PFO erst intraoperativ ( Zufallsbefund ) . Die Anwendung von Provokationsmanoevern mit PEEP-Beatmung und einem hohem Atemhubvolumen bei der intraoperativen Kontrast-TEE kann moeglicherweise zu einer Erhoehung der Nachweisquote eines PFO mit Rechts-links-Shunt beitragen . Eine 100%ige Sensitivitaet wird hiermit jedoch nicht erreicht falsch negative Befunde , lassen sich nicht ausschliessen .
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[ "umlsterm" ]
pancreatitis is an umlsterm, pancreatitis is an umlsterm, mortality is an umlsterm, patients is an umlsterm, form is an umlsterm, disease is an umlsterm, therapeutic is an umlsterm, treatment is an umlsterm, necrotizing pancreatitis is an umlsterm, All is an umlsterm, patients is an umlsterm, signs is an umlsterm, pancreatic is an umlsterm, ultrasound is an umlsterm, patients is an umlsterm, nature is an umlsterm, disease is an umlsterm, patients is an umlsterm, signs is an umlsterm, infection is an umlsterm, pancreatic is an umlsterm, necroses is an umlsterm, acute abdomen is an umlsterm, complications is an umlsterm, pancreatitis is an umlsterm, origin is an umlsterm, cholecystectomy is an umlsterm, recurrence is an umlsterm
DerAnaesthesist.80470765.eng.abstr_task0
Sentence: Acute pancreatitis is a multietiologic entity with rather diverse clinical courses . Whereas edematous pancreatitis has a mortality of less than 1% , nowadays ; still approximately 20% of all patients with the necrotizing form succumb to the disease . To further improve therapeutic results a standardized approach should be used . For effective treatment the differentiation between edematous and necrotizing pancreatitis is crucial . All patients with signs of pancreatic necroses during abdominal ultrasound and patients with organ insufficiencies should undergo a CT-scan to define exactly the nature and the extent of the disease . Primarily all patients are treated conservatively . Main indications for operative intervention are signs for infection of pancreatic necroses and an acute abdomen due to local complications of acute pancreatitis . In cases of biliary origin an elective cholecystectomy has to be performed during a free interval to prevent a recurrence . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Acute pancreatitis is a multietiologic entity with rather diverse clinical courses . Whereas edematous pancreatitis has a mortality of less than 1% , nowadays ; still approximately 20% of all patients with the necrotizing form succumb to the disease . To further improve therapeutic results a standardized approach should be used . For effective treatment the differentiation between edematous and necrotizing pancreatitis is crucial . All patients with signs of pancreatic necroses during abdominal ultrasound and patients with organ insufficiencies should undergo a CT-scan to define exactly the nature and the extent of the disease . Primarily all patients are treated conservatively . Main indications for operative intervention are signs for infection of pancreatic necroses and an acute abdomen due to local complications of acute pancreatitis . In cases of biliary origin an elective cholecystectomy has to be performed during a free interval to prevent a recurrence .
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[ "umlsterm" ]
pancreatitis is an umlsterm, pancreatitis is an umlsterm, mortality is an umlsterm, patients is an umlsterm, form is an umlsterm, disease is an umlsterm, therapeutic is an umlsterm, treatment is an umlsterm, necrotizing pancreatitis is an umlsterm, All is an umlsterm, patients is an umlsterm, signs is an umlsterm, pancreatic is an umlsterm, ultrasound is an umlsterm, patients is an umlsterm, nature is an umlsterm, disease is an umlsterm, patients is an umlsterm, signs is an umlsterm, infection is an umlsterm, pancreatic is an umlsterm, necroses is an umlsterm, acute abdomen is an umlsterm, complications is an umlsterm, pancreatitis is an umlsterm, origin is an umlsterm, cholecystectomy is an umlsterm, recurrence is an umlsterm
DerAnaesthesist.80470765.eng.abstr_task1
Sentence: Acute pancreatitis is a multietiologic entity with rather diverse clinical courses . Whereas edematous pancreatitis has a mortality of less than 1% , nowadays ; still approximately 20% of all patients with the necrotizing form succumb to the disease . To further improve therapeutic results a standardized approach should be used . For effective treatment the differentiation between edematous and necrotizing pancreatitis is crucial . All patients with signs of pancreatic necroses during abdominal ultrasound and patients with organ insufficiencies should undergo a CT-scan to define exactly the nature and the extent of the disease . Primarily all patients are treated conservatively . Main indications for operative intervention are signs for infection of pancreatic necroses and an acute abdomen due to local complications of acute pancreatitis . In cases of biliary origin an elective cholecystectomy has to be performed during a free interval to prevent a recurrence . Instructions: please typing these entity words according to sentence: pancreatitis, pancreatitis, mortality, patients, form, disease, therapeutic, treatment, necrotizing pancreatitis, All, patients, signs, pancreatic, ultrasound, patients, nature, disease, patients, signs, infection, pancreatic, necroses, acute abdomen, complications, pancreatitis, origin, cholecystectomy, recurrence Options: umlsterm
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Acute pancreatitis is a multietiologic entity with rather diverse clinical courses . Whereas edematous pancreatitis has a mortality of less than 1% , nowadays ; still approximately 20% of all patients with the necrotizing form succumb to the disease . To further improve therapeutic results a standardized approach should be used . For effective treatment the differentiation between edematous and necrotizing pancreatitis is crucial . All patients with signs of pancreatic necroses during abdominal ultrasound and patients with organ insufficiencies should undergo a CT-scan to define exactly the nature and the extent of the disease . Primarily all patients are treated conservatively . Main indications for operative intervention are signs for infection of pancreatic necroses and an acute abdomen due to local complications of acute pancreatitis . In cases of biliary origin an elective cholecystectomy has to be performed during a free interval to prevent a recurrence .
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[ "umlsterm" ]
pancreatitis, pancreatitis, mortality, patients, form, disease, therapeutic, treatment, necrotizing pancreatitis, All, patients, signs, pancreatic, ultrasound, patients, nature, disease, patients, signs, infection, pancreatic, necroses, acute abdomen, complications, pancreatitis, origin, cholecystectomy, recurrence
DerAnaesthesist.80470765.eng.abstr_task2
Sentence: Acute pancreatitis is a multietiologic entity with rather diverse clinical courses . Whereas edematous pancreatitis has a mortality of less than 1% , nowadays ; still approximately 20% of all patients with the necrotizing form succumb to the disease . To further improve therapeutic results a standardized approach should be used . For effective treatment the differentiation between edematous and necrotizing pancreatitis is crucial . All patients with signs of pancreatic necroses during abdominal ultrasound and patients with organ insufficiencies should undergo a CT-scan to define exactly the nature and the extent of the disease . Primarily all patients are treated conservatively . Main indications for operative intervention are signs for infection of pancreatic necroses and an acute abdomen due to local complications of acute pancreatitis . In cases of biliary origin an elective cholecystectomy has to be performed during a free interval to prevent a recurrence . Instructions: please extract entity words from the input sentence
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Acute pancreatitis is a multietiologic entity with rather diverse clinical courses . Whereas edematous pancreatitis has a mortality of less than 1% , nowadays ; still approximately 20% of all patients with the necrotizing form succumb to the disease . To further improve therapeutic results a standardized approach should be used . For effective treatment the differentiation between edematous and necrotizing pancreatitis is crucial . All patients with signs of pancreatic necroses during abdominal ultrasound and patients with organ insufficiencies should undergo a CT-scan to define exactly the nature and the extent of the disease . Primarily all patients are treated conservatively . Main indications for operative intervention are signs for infection of pancreatic necroses and an acute abdomen due to local complications of acute pancreatitis . In cases of biliary origin an elective cholecystectomy has to be performed during a free interval to prevent a recurrence .
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[ "umlsterm" ]
MC1R is a Gene, melanocortin 1 receptor is a Gene, MC1R is a Gene, MC1R is a Gene, MC1R is a Gene, MC1R is a Gene, MC1R is a Gene, p. V60L is a SNP, p. V92 M is a SNP, p. D84E is a SNP, p. R151C is a SNP, p. R160W is a SNP, p. R163Q is a SNP, p. D294H is a SNP, MC1R is a Gene, MC1R is a Gene
572_task0
Sentence: Comprehensive evaluation of allele frequency differences of MC1R variants across populations. The melanocortin 1 receptor (MC1R), a member of the G protein-coupled receptors superfamily, mediates the response to melanocortins and is currently the best-described contributor to normal pigment variation in humans. A remarkably large number of natural polymorphisms, or variants, of the MC1R gene have been identified in different populations. Some of these variants have been associated with specific hair and skin color phenotypes, the presence of freckling, and melanoma and nonmelanoma skin cancer risk. Interestingly, some MC1R variants have been associated with skin cancer beyond their effects on pigmentation. Although the red hair color variants (RHC variants) have been associated with skin cancer risk in the Celtic population, studies in darkly-pigmented Caucasian populations have demonstrated the importance of non-RHC MC1R variants on skin cancer risk as well. We have reviewed and compared allele frequency differences of MC1R variants across geographic regions. We observed large differences in the distribution of variants across populations, with a prominent difference between lightly and darkly-pigmented individuals. Moreover, among Caucasian groups, there were seven variants (p.V60L, p.V92M, p.D84E, p.R151C, p.R160W, p.R163Q, and p.D294H) with significantly different allele frequencies. Exploring differences in allele frequencies of MC1R variants across populations with varying pigmentation and differing skin cancer risk may improve our understanding of the complex relationship between MC1R, pigmentation, and carcinogenesis. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Gene, SNP
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Comprehensive evaluation of allele frequency differences of MC1R variants across populations. The melanocortin 1 receptor (MC1R), a member of the G protein-coupled receptors superfamily, mediates the response to melanocortins and is currently the best-described contributor to normal pigment variation in humans. A remarkably large number of natural polymorphisms, or variants, of the MC1R gene have been identified in different populations. Some of these variants have been associated with specific hair and skin color phenotypes, the presence of freckling, and melanoma and nonmelanoma skin cancer risk. Interestingly, some MC1R variants have been associated with skin cancer beyond their effects on pigmentation. Although the red hair color variants (RHC variants) have been associated with skin cancer risk in the Celtic population, studies in darkly-pigmented Caucasian populations have demonstrated the importance of non-RHC MC1R variants on skin cancer risk as well. We have reviewed and compared allele frequency differences of MC1R variants across geographic regions. We observed large differences in the distribution of variants across populations, with a prominent difference between lightly and darkly-pigmented individuals. Moreover, among Caucasian groups, there were seven variants (p.V60L, p.V92M, p.D84E, p.R151C, p.R160W, p.R163Q, and p.D294H) with significantly different allele frequencies. Exploring differences in allele frequencies of MC1R variants across populations with varying pigmentation and differing skin cancer risk may improve our understanding of the complex relationship between MC1R, pigmentation, and carcinogenesis.
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[ "Gene", "SNP" ]
MC1R is a Gene, melanocortin 1 receptor is a Gene, MC1R is a Gene, MC1R is a Gene, MC1R is a Gene, MC1R is a Gene, MC1R is a Gene, p. V60L is a SNP, p. V92 M is a SNP, p. D84E is a SNP, p. R151C is a SNP, p. R160W is a SNP, p. R163Q is a SNP, p. D294H is a SNP, MC1R is a Gene, MC1R is a Gene
572_task1
Sentence: Comprehensive evaluation of allele frequency differences of MC1R variants across populations. The melanocortin 1 receptor (MC1R), a member of the G protein-coupled receptors superfamily, mediates the response to melanocortins and is currently the best-described contributor to normal pigment variation in humans. A remarkably large number of natural polymorphisms, or variants, of the MC1R gene have been identified in different populations. Some of these variants have been associated with specific hair and skin color phenotypes, the presence of freckling, and melanoma and nonmelanoma skin cancer risk. Interestingly, some MC1R variants have been associated with skin cancer beyond their effects on pigmentation. Although the red hair color variants (RHC variants) have been associated with skin cancer risk in the Celtic population, studies in darkly-pigmented Caucasian populations have demonstrated the importance of non-RHC MC1R variants on skin cancer risk as well. We have reviewed and compared allele frequency differences of MC1R variants across geographic regions. We observed large differences in the distribution of variants across populations, with a prominent difference between lightly and darkly-pigmented individuals. Moreover, among Caucasian groups, there were seven variants (p.V60L, p.V92M, p.D84E, p.R151C, p.R160W, p.R163Q, and p.D294H) with significantly different allele frequencies. Exploring differences in allele frequencies of MC1R variants across populations with varying pigmentation and differing skin cancer risk may improve our understanding of the complex relationship between MC1R, pigmentation, and carcinogenesis. Instructions: please typing these entity words according to sentence: MC1R, melanocortin 1 receptor, MC1R, MC1R, MC1R, MC1R, MC1R, p. V60L, p. V92 M, p. D84E, p. R151C, p. R160W, p. R163Q, p. D294H, MC1R, MC1R Options: Gene, SNP
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Comprehensive evaluation of allele frequency differences of MC1R variants across populations. The melanocortin 1 receptor (MC1R), a member of the G protein-coupled receptors superfamily, mediates the response to melanocortins and is currently the best-described contributor to normal pigment variation in humans. A remarkably large number of natural polymorphisms, or variants, of the MC1R gene have been identified in different populations. Some of these variants have been associated with specific hair and skin color phenotypes, the presence of freckling, and melanoma and nonmelanoma skin cancer risk. Interestingly, some MC1R variants have been associated with skin cancer beyond their effects on pigmentation. Although the red hair color variants (RHC variants) have been associated with skin cancer risk in the Celtic population, studies in darkly-pigmented Caucasian populations have demonstrated the importance of non-RHC MC1R variants on skin cancer risk as well. We have reviewed and compared allele frequency differences of MC1R variants across geographic regions. We observed large differences in the distribution of variants across populations, with a prominent difference between lightly and darkly-pigmented individuals. Moreover, among Caucasian groups, there were seven variants (p.V60L, p.V92M, p.D84E, p.R151C, p.R160W, p.R163Q, and p.D294H) with significantly different allele frequencies. Exploring differences in allele frequencies of MC1R variants across populations with varying pigmentation and differing skin cancer risk may improve our understanding of the complex relationship between MC1R, pigmentation, and carcinogenesis.
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[ "Gene", "SNP" ]
MC1R, melanocortin 1 receptor, MC1R, MC1R, MC1R, MC1R, MC1R, p. V60L, p. V92 M, p. D84E, p. R151C, p. R160W, p. R163Q, p. D294H, MC1R, MC1R
572_task2
Sentence: Comprehensive evaluation of allele frequency differences of MC1R variants across populations. The melanocortin 1 receptor (MC1R), a member of the G protein-coupled receptors superfamily, mediates the response to melanocortins and is currently the best-described contributor to normal pigment variation in humans. A remarkably large number of natural polymorphisms, or variants, of the MC1R gene have been identified in different populations. Some of these variants have been associated with specific hair and skin color phenotypes, the presence of freckling, and melanoma and nonmelanoma skin cancer risk. Interestingly, some MC1R variants have been associated with skin cancer beyond their effects on pigmentation. Although the red hair color variants (RHC variants) have been associated with skin cancer risk in the Celtic population, studies in darkly-pigmented Caucasian populations have demonstrated the importance of non-RHC MC1R variants on skin cancer risk as well. We have reviewed and compared allele frequency differences of MC1R variants across geographic regions. We observed large differences in the distribution of variants across populations, with a prominent difference between lightly and darkly-pigmented individuals. Moreover, among Caucasian groups, there were seven variants (p.V60L, p.V92M, p.D84E, p.R151C, p.R160W, p.R163Q, and p.D294H) with significantly different allele frequencies. Exploring differences in allele frequencies of MC1R variants across populations with varying pigmentation and differing skin cancer risk may improve our understanding of the complex relationship between MC1R, pigmentation, and carcinogenesis. Instructions: please extract entity words from the input sentence
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Comprehensive evaluation of allele frequency differences of MC1R variants across populations. The melanocortin 1 receptor (MC1R), a member of the G protein-coupled receptors superfamily, mediates the response to melanocortins and is currently the best-described contributor to normal pigment variation in humans. A remarkably large number of natural polymorphisms, or variants, of the MC1R gene have been identified in different populations. Some of these variants have been associated with specific hair and skin color phenotypes, the presence of freckling, and melanoma and nonmelanoma skin cancer risk. Interestingly, some MC1R variants have been associated with skin cancer beyond their effects on pigmentation. Although the red hair color variants (RHC variants) have been associated with skin cancer risk in the Celtic population, studies in darkly-pigmented Caucasian populations have demonstrated the importance of non-RHC MC1R variants on skin cancer risk as well. We have reviewed and compared allele frequency differences of MC1R variants across geographic regions. We observed large differences in the distribution of variants across populations, with a prominent difference between lightly and darkly-pigmented individuals. Moreover, among Caucasian groups, there were seven variants (p.V60L, p.V92M, p.D84E, p.R151C, p.R160W, p.R163Q, and p.D294H) with significantly different allele frequencies. Exploring differences in allele frequencies of MC1R variants across populations with varying pigmentation and differing skin cancer risk may improve our understanding of the complex relationship between MC1R, pigmentation, and carcinogenesis.
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[ "Gene", "SNP" ]
Saponin is a CHEMICAL, saponin is a CHEMICAL, paracetamol is a CHEMICAL, carbon tetrachloride is a CHEMICAL, CCl4 is a CHEMICAL, silymarin is a CHEMICAL, CCl4 is a CHEMICAL, silymarin is a CHEMICAL, aspartate aminotransferase is a GENE-Y, alanine aminotransferase is a GENE-N, lactate dehydrogenase is a GENE-N, LDH is a GENE-N, glutathione is a CHEMICAL, GSH is a CHEMICAL, malondialdehyde is a CHEMICAL, MDA is a CHEMICAL, CCl4 is a CHEMICAL, serum transaminases is a GENE-N, LDH is a GENE-N, MDA is a CHEMICAL, GSH is a CHEMICAL, CCl4 is a CHEMICAL, silymarin is a CHEMICAL, ethylmorphine - N - demethylase is a GENE-N, aniline 4-hydroxylase is a GENE-N, cytochrome P450 is a GENE-N, CCl4 is a CHEMICAL, silymarin is a CHEMICAL, CCl4 is a CHEMICAL, silymarin is a CHEMICAL
30177_task0
Sentence: Protective Effects of a Purified Saponin Mixture from Astragalus corniculatus Bieb., in vivo Hepatotoxicity Models. In this study, the in vivo effects of a purified saponin mixture (PSM), obtained from Astragalus corniculatus Bieb., were investigated using two in vivo hepatotoxicity models based on liver damage caused by paracetamol (PC) and carbon tetrachloride (CCl4 ). The effects of PSM were compared with silymarin. Male Wistar rats were challenged orally with 20% CCl4 or PC (2 g/kg) four days after being pre-treated with PSM (100 mg/kg) or silymarin (200 mg/kg). A significant decrease of aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase (LDH) activities and glutathione (GSH) levels and an increase of malondialdehyde (MDA) quantity was observed after CCl4 and PC administration alone. PSM pre-treatment decreased serum transaminases and LDH activities and MDA levels and increased the levels of cell protector GSH. Biotransformation phase I enzymes were also assessed in both models. In the CCl4 hepatotoxicity model, pre-treatment with PSM or silymarin resulted in significantly increased activities of ethylmorphine-N-demethylase and aniline 4-hydroxylase activity and cytochrome P450, compared to the CCl4 only group. Neither silymarin nor PSM influenced PC biotransformation. Our results suggest that PSM, obtained from A. corniculatus, Bieb. showed in vivo hepatoprotective and antioxidant activities against CCl4 and PC-induced liver damage comparable to that of silymarin. Copyright © 2012 John Wiley & Sons, Ltd. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N, GENE-Y, CHEMICAL
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Protective Effects of a Purified Saponin Mixture from Astragalus corniculatus Bieb., in vivo Hepatotoxicity Models. In this study, the in vivo effects of a purified saponin mixture (PSM), obtained from Astragalus corniculatus Bieb., were investigated using two in vivo hepatotoxicity models based on liver damage caused by paracetamol (PC) and carbon tetrachloride (CCl4 ). The effects of PSM were compared with silymarin. Male Wistar rats were challenged orally with 20% CCl4 or PC (2 g/kg) four days after being pre-treated with PSM (100 mg/kg) or silymarin (200 mg/kg). A significant decrease of aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase (LDH) activities and glutathione (GSH) levels and an increase of malondialdehyde (MDA) quantity was observed after CCl4 and PC administration alone. PSM pre-treatment decreased serum transaminases and LDH activities and MDA levels and increased the levels of cell protector GSH. Biotransformation phase I enzymes were also assessed in both models. In the CCl4 hepatotoxicity model, pre-treatment with PSM or silymarin resulted in significantly increased activities of ethylmorphine-N-demethylase and aniline 4-hydroxylase activity and cytochrome P450, compared to the CCl4 only group. Neither silymarin nor PSM influenced PC biotransformation. Our results suggest that PSM, obtained from A. corniculatus, Bieb. showed in vivo hepatoprotective and antioxidant activities against CCl4 and PC-induced liver damage comparable to that of silymarin. Copyright © 2012 John Wiley & Sons, Ltd.
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[ "GENE-N", "GENE-Y", "CHEMICAL" ]
Saponin is a CHEMICAL, saponin is a CHEMICAL, paracetamol is a CHEMICAL, carbon tetrachloride is a CHEMICAL, CCl4 is a CHEMICAL, silymarin is a CHEMICAL, CCl4 is a CHEMICAL, silymarin is a CHEMICAL, aspartate aminotransferase is a GENE-Y, alanine aminotransferase is a GENE-N, lactate dehydrogenase is a GENE-N, LDH is a GENE-N, glutathione is a CHEMICAL, GSH is a CHEMICAL, malondialdehyde is a CHEMICAL, MDA is a CHEMICAL, CCl4 is a CHEMICAL, serum transaminases is a GENE-N, LDH is a GENE-N, MDA is a CHEMICAL, GSH is a CHEMICAL, CCl4 is a CHEMICAL, silymarin is a CHEMICAL, ethylmorphine - N - demethylase is a GENE-N, aniline 4-hydroxylase is a GENE-N, cytochrome P450 is a GENE-N, CCl4 is a CHEMICAL, silymarin is a CHEMICAL, CCl4 is a CHEMICAL, silymarin is a CHEMICAL
30177_task1
Sentence: Protective Effects of a Purified Saponin Mixture from Astragalus corniculatus Bieb., in vivo Hepatotoxicity Models. In this study, the in vivo effects of a purified saponin mixture (PSM), obtained from Astragalus corniculatus Bieb., were investigated using two in vivo hepatotoxicity models based on liver damage caused by paracetamol (PC) and carbon tetrachloride (CCl4 ). The effects of PSM were compared with silymarin. Male Wistar rats were challenged orally with 20% CCl4 or PC (2 g/kg) four days after being pre-treated with PSM (100 mg/kg) or silymarin (200 mg/kg). A significant decrease of aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase (LDH) activities and glutathione (GSH) levels and an increase of malondialdehyde (MDA) quantity was observed after CCl4 and PC administration alone. PSM pre-treatment decreased serum transaminases and LDH activities and MDA levels and increased the levels of cell protector GSH. Biotransformation phase I enzymes were also assessed in both models. In the CCl4 hepatotoxicity model, pre-treatment with PSM or silymarin resulted in significantly increased activities of ethylmorphine-N-demethylase and aniline 4-hydroxylase activity and cytochrome P450, compared to the CCl4 only group. Neither silymarin nor PSM influenced PC biotransformation. Our results suggest that PSM, obtained from A. corniculatus, Bieb. showed in vivo hepatoprotective and antioxidant activities against CCl4 and PC-induced liver damage comparable to that of silymarin. Copyright © 2012 John Wiley & Sons, Ltd. Instructions: please typing these entity words according to sentence: Saponin, saponin, paracetamol, carbon tetrachloride, CCl4, silymarin, CCl4, silymarin, aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, LDH, glutathione, GSH, malondialdehyde, MDA, CCl4, serum transaminases, LDH, MDA, GSH, CCl4, silymarin, ethylmorphine - N - demethylase, aniline 4-hydroxylase, cytochrome P450, CCl4, silymarin, CCl4, silymarin Options: GENE-N, GENE-Y, CHEMICAL
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Protective Effects of a Purified Saponin Mixture from Astragalus corniculatus Bieb., in vivo Hepatotoxicity Models. In this study, the in vivo effects of a purified saponin mixture (PSM), obtained from Astragalus corniculatus Bieb., were investigated using two in vivo hepatotoxicity models based on liver damage caused by paracetamol (PC) and carbon tetrachloride (CCl4 ). The effects of PSM were compared with silymarin. Male Wistar rats were challenged orally with 20% CCl4 or PC (2 g/kg) four days after being pre-treated with PSM (100 mg/kg) or silymarin (200 mg/kg). A significant decrease of aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase (LDH) activities and glutathione (GSH) levels and an increase of malondialdehyde (MDA) quantity was observed after CCl4 and PC administration alone. PSM pre-treatment decreased serum transaminases and LDH activities and MDA levels and increased the levels of cell protector GSH. Biotransformation phase I enzymes were also assessed in both models. In the CCl4 hepatotoxicity model, pre-treatment with PSM or silymarin resulted in significantly increased activities of ethylmorphine-N-demethylase and aniline 4-hydroxylase activity and cytochrome P450, compared to the CCl4 only group. Neither silymarin nor PSM influenced PC biotransformation. Our results suggest that PSM, obtained from A. corniculatus, Bieb. showed in vivo hepatoprotective and antioxidant activities against CCl4 and PC-induced liver damage comparable to that of silymarin. Copyright © 2012 John Wiley & Sons, Ltd.
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[ "GENE-N", "GENE-Y", "CHEMICAL" ]
Saponin, saponin, paracetamol, carbon tetrachloride, CCl4, silymarin, CCl4, silymarin, aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, LDH, glutathione, GSH, malondialdehyde, MDA, CCl4, serum transaminases, LDH, MDA, GSH, CCl4, silymarin, ethylmorphine - N - demethylase, aniline 4-hydroxylase, cytochrome P450, CCl4, silymarin, CCl4, silymarin
30177_task2
Sentence: Protective Effects of a Purified Saponin Mixture from Astragalus corniculatus Bieb., in vivo Hepatotoxicity Models. In this study, the in vivo effects of a purified saponin mixture (PSM), obtained from Astragalus corniculatus Bieb., were investigated using two in vivo hepatotoxicity models based on liver damage caused by paracetamol (PC) and carbon tetrachloride (CCl4 ). The effects of PSM were compared with silymarin. Male Wistar rats were challenged orally with 20% CCl4 or PC (2 g/kg) four days after being pre-treated with PSM (100 mg/kg) or silymarin (200 mg/kg). A significant decrease of aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase (LDH) activities and glutathione (GSH) levels and an increase of malondialdehyde (MDA) quantity was observed after CCl4 and PC administration alone. PSM pre-treatment decreased serum transaminases and LDH activities and MDA levels and increased the levels of cell protector GSH. Biotransformation phase I enzymes were also assessed in both models. In the CCl4 hepatotoxicity model, pre-treatment with PSM or silymarin resulted in significantly increased activities of ethylmorphine-N-demethylase and aniline 4-hydroxylase activity and cytochrome P450, compared to the CCl4 only group. Neither silymarin nor PSM influenced PC biotransformation. Our results suggest that PSM, obtained from A. corniculatus, Bieb. showed in vivo hepatoprotective and antioxidant activities against CCl4 and PC-induced liver damage comparable to that of silymarin. Copyright © 2012 John Wiley & Sons, Ltd. Instructions: please extract entity words from the input sentence
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Protective Effects of a Purified Saponin Mixture from Astragalus corniculatus Bieb., in vivo Hepatotoxicity Models. In this study, the in vivo effects of a purified saponin mixture (PSM), obtained from Astragalus corniculatus Bieb., were investigated using two in vivo hepatotoxicity models based on liver damage caused by paracetamol (PC) and carbon tetrachloride (CCl4 ). The effects of PSM were compared with silymarin. Male Wistar rats were challenged orally with 20% CCl4 or PC (2 g/kg) four days after being pre-treated with PSM (100 mg/kg) or silymarin (200 mg/kg). A significant decrease of aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase (LDH) activities and glutathione (GSH) levels and an increase of malondialdehyde (MDA) quantity was observed after CCl4 and PC administration alone. PSM pre-treatment decreased serum transaminases and LDH activities and MDA levels and increased the levels of cell protector GSH. Biotransformation phase I enzymes were also assessed in both models. In the CCl4 hepatotoxicity model, pre-treatment with PSM or silymarin resulted in significantly increased activities of ethylmorphine-N-demethylase and aniline 4-hydroxylase activity and cytochrome P450, compared to the CCl4 only group. Neither silymarin nor PSM influenced PC biotransformation. Our results suggest that PSM, obtained from A. corniculatus, Bieb. showed in vivo hepatoprotective and antioxidant activities against CCl4 and PC-induced liver damage comparable to that of silymarin. Copyright © 2012 John Wiley & Sons, Ltd.
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[ "GENE-N", "GENE-Y", "CHEMICAL" ]
rifampin is a DRUG, barbiturates is a GROUP, phenytoin sodium is a DRUG, carbamazepine is a DRUG, griseofulvin is a DRUG, ampicillin is a DRUG, tetracyclines is a GROUP
Desogestrel_ddi_task0
Sentence: Reduced efficacy and increased incidence of breakthrough bleeding and menstrual irregularities have been associated with concomitant use of rifampin. A similar association, though less marked, has been suggested with barbiturates, phenyl-butazone, phenytoin sodium, carbamazepine and possibly with griseofulvin, ampicillin, and tetracyclines (72) . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GROUP, DRUG
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "B-DRUG", "I-DRUG", "O", "B-DRUG", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "B-GROUP", "O", "O", "O", "O" ]
Reduced efficacy and increased incidence of breakthrough bleeding and menstrual irregularities have been associated with concomitant use of rifampin. A similar association, though less marked, has been suggested with barbiturates, phenyl-butazone, phenytoin sodium, carbamazepine and possibly with griseofulvin, ampicillin, and tetracyclines (72) .
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[ "DRUG", "GROUP" ]
rifampin is a DRUG, barbiturates is a GROUP, phenytoin sodium is a DRUG, carbamazepine is a DRUG, griseofulvin is a DRUG, ampicillin is a DRUG, tetracyclines is a GROUP
Desogestrel_ddi_task1
Sentence: Reduced efficacy and increased incidence of breakthrough bleeding and menstrual irregularities have been associated with concomitant use of rifampin. A similar association, though less marked, has been suggested with barbiturates, phenyl-butazone, phenytoin sodium, carbamazepine and possibly with griseofulvin, ampicillin, and tetracyclines (72) . Instructions: please typing these entity words according to sentence: rifampin, barbiturates, phenytoin sodium, carbamazepine, griseofulvin, ampicillin, tetracyclines Options: GROUP, DRUG
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "B-DRUG", "I-DRUG", "O", "B-DRUG", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "B-GROUP", "O", "O", "O", "O" ]
Reduced efficacy and increased incidence of breakthrough bleeding and menstrual irregularities have been associated with concomitant use of rifampin. A similar association, though less marked, has been suggested with barbiturates, phenyl-butazone, phenytoin sodium, carbamazepine and possibly with griseofulvin, ampicillin, and tetracyclines (72) .
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[ "DRUG", "GROUP" ]
rifampin, barbiturates, phenytoin sodium, carbamazepine, griseofulvin, ampicillin, tetracyclines
Desogestrel_ddi_task2
Sentence: Reduced efficacy and increased incidence of breakthrough bleeding and menstrual irregularities have been associated with concomitant use of rifampin. A similar association, though less marked, has been suggested with barbiturates, phenyl-butazone, phenytoin sodium, carbamazepine and possibly with griseofulvin, ampicillin, and tetracyclines (72) . Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "B-DRUG", "I-DRUG", "O", "B-DRUG", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "B-GROUP", "O", "O", "O", "O" ]
Reduced efficacy and increased incidence of breakthrough bleeding and menstrual irregularities have been associated with concomitant use of rifampin. A similar association, though less marked, has been suggested with barbiturates, phenyl-butazone, phenytoin sodium, carbamazepine and possibly with griseofulvin, ampicillin, and tetracyclines (72) .
[ "Reduced", "efficacy", "and", "increased", "incidence", "of", "breakthrough", "bleeding", "and", "menstrual", "irregularities", "have", "been", "associated", "with", "concomitant", "use", "of", "rifampin", ".", "A", "similar", "association", ",", "though", "less", "marked", ",", "has", "been", "suggested", "with", "barbiturates", ",", "phenyl", "-", "butazone", ",", "phenytoin", "sodium", ",", "carbamazepine", "and", "possibly", "with", "griseofulvin", ",", "ampicillin", ",", "and", "tetracyclines", "(", "72", ")", "." ]
[ "DRUG", "GROUP" ]
Probenecid is a DRUG, cephalosporins is a GROUP, cephalosporin is a GROUP, cephalosporins is a GROUP
Cefazolin_ddi_task0
Sentence: Probenecid may decrease renal tubular secretion of cephalosporins when used concurrently, resulting in increased and more prolonged cephalosporin blood levels. Drug/Laboratory Test Interactions A false positive reaction for glucose in the urine may occur with Benedicts solution, Fehlings solution or with CLINITEST tablets, but not with enzyme-based tests such as CLINISTIX . Positive direct and indirect antiglobulin (Coombs) tests have occurred; these may also occur in neonates whose mothers received cephalosporins before delivery. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GROUP, DRUG
[ "B-DRUG", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O" ]
Probenecid may decrease renal tubular secretion of cephalosporins when used concurrently, resulting in increased and more prolonged cephalosporin blood levels. Drug/Laboratory Test Interactions A false positive reaction for glucose in the urine may occur with Benedicts solution, Fehlings solution or with CLINITEST tablets, but not with enzyme-based tests such as CLINISTIX . Positive direct and indirect antiglobulin (Coombs) tests have occurred; these may also occur in neonates whose mothers received cephalosporins before delivery.
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[ "GROUP", "DRUG" ]
Probenecid is a DRUG, cephalosporins is a GROUP, cephalosporin is a GROUP, cephalosporins is a GROUP
Cefazolin_ddi_task1
Sentence: Probenecid may decrease renal tubular secretion of cephalosporins when used concurrently, resulting in increased and more prolonged cephalosporin blood levels. Drug/Laboratory Test Interactions A false positive reaction for glucose in the urine may occur with Benedicts solution, Fehlings solution or with CLINITEST tablets, but not with enzyme-based tests such as CLINISTIX . Positive direct and indirect antiglobulin (Coombs) tests have occurred; these may also occur in neonates whose mothers received cephalosporins before delivery. Instructions: please typing these entity words according to sentence: Probenecid, cephalosporins, cephalosporin, cephalosporins Options: GROUP, DRUG
[ "B-DRUG", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O" ]
Probenecid may decrease renal tubular secretion of cephalosporins when used concurrently, resulting in increased and more prolonged cephalosporin blood levels. Drug/Laboratory Test Interactions A false positive reaction for glucose in the urine may occur with Benedicts solution, Fehlings solution or with CLINITEST tablets, but not with enzyme-based tests such as CLINISTIX . Positive direct and indirect antiglobulin (Coombs) tests have occurred; these may also occur in neonates whose mothers received cephalosporins before delivery.
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[ "GROUP", "DRUG" ]
Probenecid, cephalosporins, cephalosporin, cephalosporins
Cefazolin_ddi_task2
Sentence: Probenecid may decrease renal tubular secretion of cephalosporins when used concurrently, resulting in increased and more prolonged cephalosporin blood levels. Drug/Laboratory Test Interactions A false positive reaction for glucose in the urine may occur with Benedicts solution, Fehlings solution or with CLINITEST tablets, but not with enzyme-based tests such as CLINISTIX . Positive direct and indirect antiglobulin (Coombs) tests have occurred; these may also occur in neonates whose mothers received cephalosporins before delivery. Instructions: please extract entity words from the input sentence
[ "B-DRUG", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O" ]
Probenecid may decrease renal tubular secretion of cephalosporins when used concurrently, resulting in increased and more prolonged cephalosporin blood levels. Drug/Laboratory Test Interactions A false positive reaction for glucose in the urine may occur with Benedicts solution, Fehlings solution or with CLINITEST tablets, but not with enzyme-based tests such as CLINISTIX . Positive direct and indirect antiglobulin (Coombs) tests have occurred; these may also occur in neonates whose mothers received cephalosporins before delivery.
[ "Probenecid", "may", "decrease", "renal", "tubular", "secretion", "of", "cephalosporins", "when", "used", "concurrently", ",", "resulting", "in", "increased", "and", "more", "prolonged", "cephalosporin", "blood", "levels", ".", "Drug", "/", "Laboratory", "Test", "Interactions", "A", "false", "positive", "reaction", "for", "glucose", "in", "the", "urine", "may", "occur", "with", "Benedicts", "solution", ",", "Fehlings", "solution", "or", "with", "CLINITEST", " ", "tablets", ",", "but", "not", "with", "enzyme", "-", "based", "tests", "such", "as", "CLINISTIX", ".", "Positive", "direct", "and", "indirect", "antiglobulin", "(", "Coombs", ")", "tests", "have", "occurred", ";", "these", "may", "also", "occur", "in", "neonates", "whose", "mothers", "received", "cephalosporins", "before", "delivery", "." ]
[ "GROUP", "DRUG" ]
perianal warts is a DISEASE, acute toxicity is a ADVERSE, chronic toxicity is a ADVERSE, mutagenicity is a ADVERSE, reproductive toxicity is a ADVERSE, carcinogenicity is a ADVERSE
example-28_task0
Sentence: Current regulatory toxicology perspectives on the development of herbal medicines to prescription drug products in the United States. Toxicological studies constitute an essential part of the effort in developing an herbal medicine into a drug product. The US food and drug administration (FDA) published a guidance to assist academic and industry sponsors in the development of this unique group of drug products, and has recently approved an new drug application (NDA) based on green tea extract (Veregen) for topical treatment of genital and perianal warts. In this article, current regulatory views on issues related to requirements and recommendations on various types of nonclinical toxicity studies in support of clinical trials and filing an NDA for a herbal medicine, including pharm/tox aspects of green tea extract (Veregen) NDA, are discussed. Topics include nonclinical pharmacology/toxicology perspectives on herbal nomenclature and its identification, previous human experience and initial clinical trial proposal, regulatory aspects of acute toxicity studies, chronic toxicity studies, mutagenicity studies, reproductive toxicity studies, and carcinogenicity studies on botanicals. Certain regulatory review-related issues are also presented. It is anticipated that through a proactive two-way communication between the Agency and the sponsor, toxicological development of botanical drug product can be significantly facilitated. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: ADVERSE, DISEASE
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Current regulatory toxicology perspectives on the development of herbal medicines to prescription drug products in the United States. Toxicological studies constitute an essential part of the effort in developing an herbal medicine into a drug product. The US food and drug administration (FDA) published a guidance to assist academic and industry sponsors in the development of this unique group of drug products, and has recently approved an new drug application (NDA) based on green tea extract (Veregen) for topical treatment of genital and perianal warts. In this article, current regulatory views on issues related to requirements and recommendations on various types of nonclinical toxicity studies in support of clinical trials and filing an NDA for a herbal medicine, including pharm/tox aspects of green tea extract (Veregen) NDA, are discussed. Topics include nonclinical pharmacology/toxicology perspectives on herbal nomenclature and its identification, previous human experience and initial clinical trial proposal, regulatory aspects of acute toxicity studies, chronic toxicity studies, mutagenicity studies, reproductive toxicity studies, and carcinogenicity studies on botanicals. Certain regulatory review-related issues are also presented. It is anticipated that through a proactive two-way communication between the Agency and the sponsor, toxicological development of botanical drug product can be significantly facilitated.
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[ "ADVERSE", "DISEASE" ]
perianal warts is a DISEASE, acute toxicity is a ADVERSE, chronic toxicity is a ADVERSE, mutagenicity is a ADVERSE, reproductive toxicity is a ADVERSE, carcinogenicity is a ADVERSE
example-28_task1
Sentence: Current regulatory toxicology perspectives on the development of herbal medicines to prescription drug products in the United States. Toxicological studies constitute an essential part of the effort in developing an herbal medicine into a drug product. The US food and drug administration (FDA) published a guidance to assist academic and industry sponsors in the development of this unique group of drug products, and has recently approved an new drug application (NDA) based on green tea extract (Veregen) for topical treatment of genital and perianal warts. In this article, current regulatory views on issues related to requirements and recommendations on various types of nonclinical toxicity studies in support of clinical trials and filing an NDA for a herbal medicine, including pharm/tox aspects of green tea extract (Veregen) NDA, are discussed. Topics include nonclinical pharmacology/toxicology perspectives on herbal nomenclature and its identification, previous human experience and initial clinical trial proposal, regulatory aspects of acute toxicity studies, chronic toxicity studies, mutagenicity studies, reproductive toxicity studies, and carcinogenicity studies on botanicals. Certain regulatory review-related issues are also presented. It is anticipated that through a proactive two-way communication between the Agency and the sponsor, toxicological development of botanical drug product can be significantly facilitated. Instructions: please typing these entity words according to sentence: perianal warts, acute toxicity, chronic toxicity, mutagenicity, reproductive toxicity, carcinogenicity Options: ADVERSE, DISEASE
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Current regulatory toxicology perspectives on the development of herbal medicines to prescription drug products in the United States. Toxicological studies constitute an essential part of the effort in developing an herbal medicine into a drug product. The US food and drug administration (FDA) published a guidance to assist academic and industry sponsors in the development of this unique group of drug products, and has recently approved an new drug application (NDA) based on green tea extract (Veregen) for topical treatment of genital and perianal warts. In this article, current regulatory views on issues related to requirements and recommendations on various types of nonclinical toxicity studies in support of clinical trials and filing an NDA for a herbal medicine, including pharm/tox aspects of green tea extract (Veregen) NDA, are discussed. Topics include nonclinical pharmacology/toxicology perspectives on herbal nomenclature and its identification, previous human experience and initial clinical trial proposal, regulatory aspects of acute toxicity studies, chronic toxicity studies, mutagenicity studies, reproductive toxicity studies, and carcinogenicity studies on botanicals. Certain regulatory review-related issues are also presented. It is anticipated that through a proactive two-way communication between the Agency and the sponsor, toxicological development of botanical drug product can be significantly facilitated.
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[ "ADVERSE", "DISEASE" ]
perianal warts, acute toxicity, chronic toxicity, mutagenicity, reproductive toxicity, carcinogenicity
example-28_task2
Sentence: Current regulatory toxicology perspectives on the development of herbal medicines to prescription drug products in the United States. Toxicological studies constitute an essential part of the effort in developing an herbal medicine into a drug product. The US food and drug administration (FDA) published a guidance to assist academic and industry sponsors in the development of this unique group of drug products, and has recently approved an new drug application (NDA) based on green tea extract (Veregen) for topical treatment of genital and perianal warts. In this article, current regulatory views on issues related to requirements and recommendations on various types of nonclinical toxicity studies in support of clinical trials and filing an NDA for a herbal medicine, including pharm/tox aspects of green tea extract (Veregen) NDA, are discussed. Topics include nonclinical pharmacology/toxicology perspectives on herbal nomenclature and its identification, previous human experience and initial clinical trial proposal, regulatory aspects of acute toxicity studies, chronic toxicity studies, mutagenicity studies, reproductive toxicity studies, and carcinogenicity studies on botanicals. Certain regulatory review-related issues are also presented. It is anticipated that through a proactive two-way communication between the Agency and the sponsor, toxicological development of botanical drug product can be significantly facilitated. Instructions: please extract entity words from the input sentence
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Current regulatory toxicology perspectives on the development of herbal medicines to prescription drug products in the United States. Toxicological studies constitute an essential part of the effort in developing an herbal medicine into a drug product. The US food and drug administration (FDA) published a guidance to assist academic and industry sponsors in the development of this unique group of drug products, and has recently approved an new drug application (NDA) based on green tea extract (Veregen) for topical treatment of genital and perianal warts. In this article, current regulatory views on issues related to requirements and recommendations on various types of nonclinical toxicity studies in support of clinical trials and filing an NDA for a herbal medicine, including pharm/tox aspects of green tea extract (Veregen) NDA, are discussed. Topics include nonclinical pharmacology/toxicology perspectives on herbal nomenclature and its identification, previous human experience and initial clinical trial proposal, regulatory aspects of acute toxicity studies, chronic toxicity studies, mutagenicity studies, reproductive toxicity studies, and carcinogenicity studies on botanicals. Certain regulatory review-related issues are also presented. It is anticipated that through a proactive two-way communication between the Agency and the sponsor, toxicological development of botanical drug product can be significantly facilitated.
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[ "ADVERSE", "DISEASE" ]
Syndrom is an umlsterm, Androgenexposition is an umlsterm, erwachsener is an umlsterm, Muetter is an umlsterm, Androgenkonzentration is an umlsterm, Therapie is an umlsterm, erwachsenen is an umlsterm, Frauen is an umlsterm, Methode is an umlsterm, Publikation is an umlsterm, Interviews is an umlsterm, erwachsene is an umlsterm, Frauen is an umlsterm, Syndrom is an umlsterm, Lebensqualitaet is an umlsterm, Selbstwahrnehmung is an umlsterm, Koerperwahrnehmung is an umlsterm, Sexualitaet is an umlsterm, Muetter is an umlsterm, Lebensqualitaet is an umlsterm, Interviews is an umlsterm, Erwachsenenalter is an umlsterm, androgenabhaengigen is an umlsterm, Androgenwirkung is an umlsterm, Fertilitaet is an umlsterm, Faehigkeiten is an umlsterm, Frauen is an umlsterm, Sexualitaet is an umlsterm, Frauen is an umlsterm, Muettern is an umlsterm, Frauen is an umlsterm, Beruf is an umlsterm, Muetter is an umlsterm, Behandlung is an umlsterm, erwachsene is an umlsterm, Frauen is an umlsterm, Syndrom is an umlsterm, Trauma is an umlsterm
MonatsschriftKinderheilkunde.71450815.ger.abstr_task0
Sentence: Fragestellung : Das adrenogenitale Syndrom auf Grund eines 21-Hydroxylasedefekts ist gekennzeichnet durch hohe prae- und postnatale Androgenexposition betroffener Maedchen . Eine Nachuntersuchung erwachsener Patientinnen und deren Muetter soll den Einfluss hoher Androgenkonzentration sowie den Effekt einer chronischen Erkrankung mit komplexer medikamentoeser und chirurgischer Therapie auf die sexuelle und psychosoziale Entwicklung der erwachsenen Frauen klaeren . Methode : Gegenstand dieser Publikation ist die Auswertung eines halbstandardisierten Interviews , in dem wir 45 erwachsene Frauen mit adrenogenitalem Syndrom , mit einem Durchschnittsalter von 27,0 +/- 6,64 Jahren , nach Anamnese , Lebensqualitaet , Selbstwahrnehmung , Koerperwahrnehmung , Sexualitaet und soziale Bindungen befragten . Ebenfalls befragt wurden 35 Muetter zu den Schwierigkeiten und Problemen , die sie mit der Erkrankung der Toechter hatten . Ergebnisse : Obwohl die Lebensqualitaet der Patientinnen insgesamt nicht eingeschraenkt war , zeigte die Auswertung dieser Interviews , dass ein grosser Prozentsatz , auch noch im Erwachsenenalter , an androgenabhaengigen Beschwerden wie Zyklusunregelmaessigkeiten und vermehrtem Haarwuchs , leidet . Eine vermehrte Androgenwirkung ist sicherlich auch die Ursache fuer die reduzierte Fertilitaet der Gesamtgruppe . Waehrend die sozialen Faehigkeiten der Patientinnen in der Regel sehr gut entwickelt waren , hatte die Mehrzahl der Frauen Probleme in den Bereichen sexuelle Identitaet und Partnerschaft . Dies fuehrte dazu , dass eine signifikant hoehere Zahl von Patientinnen alleinstehend und unverheiratet war , wobei bestehende Beziehungen eher stabiler und befriedigender waren als bei dem Kontrollkollektiv . Insgesamt war die Einstellung zur Sexualitaet konservativer . Der Prozentsatz von Frauen , die in einer gleichgeschlechtlichen Partnerbeziehung leben , ist nicht erhoeht . Eine maedchenspezifische Erziehung wurde von den Patientinnen ebenso wie von den Muettern verneint , allerdings hatte der groessere Teil der Frauen knabenspezifische Spiele bevorzugt . In Schulbildung und Beruf war kein Unterschied zur Kontrollgruppe zu sehen , die meisten Patientinnen waren als Angestellte in abhaengigem Arbeitsverhaeltnis taetig . Muetter wie Toechter waren mit der medizinischen Behandlung zufrieden , bedauerten allerdings , dass ihnen keine begleitende psychologische Betreuung angeboten worden war . Schlussfolgerung : Diese psychologischen Untersuchungen zeigen , dass erwachsene Frauen mit adrenogenitalem Syndrom gut mit der chronischen Erkrankung ebenso wie mit dem Trauma der Genitalfehlbildung zurechtkommen . Trotzdem bleiben Probleme in den sensitiven Bereichen der sexuellen Identifikation und geschlechtlichen Beziehungen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Fragestellung : Das adrenogenitale Syndrom auf Grund eines 21-Hydroxylasedefekts ist gekennzeichnet durch hohe prae- und postnatale Androgenexposition betroffener Maedchen . Eine Nachuntersuchung erwachsener Patientinnen und deren Muetter soll den Einfluss hoher Androgenkonzentration sowie den Effekt einer chronischen Erkrankung mit komplexer medikamentoeser und chirurgischer Therapie auf die sexuelle und psychosoziale Entwicklung der erwachsenen Frauen klaeren . Methode : Gegenstand dieser Publikation ist die Auswertung eines halbstandardisierten Interviews , in dem wir 45 erwachsene Frauen mit adrenogenitalem Syndrom , mit einem Durchschnittsalter von 27,0 +/- 6,64 Jahren , nach Anamnese , Lebensqualitaet , Selbstwahrnehmung , Koerperwahrnehmung , Sexualitaet und soziale Bindungen befragten . Ebenfalls befragt wurden 35 Muetter zu den Schwierigkeiten und Problemen , die sie mit der Erkrankung der Toechter hatten . Ergebnisse : Obwohl die Lebensqualitaet der Patientinnen insgesamt nicht eingeschraenkt war , zeigte die Auswertung dieser Interviews , dass ein grosser Prozentsatz , auch noch im Erwachsenenalter , an androgenabhaengigen Beschwerden wie Zyklusunregelmaessigkeiten und vermehrtem Haarwuchs , leidet . Eine vermehrte Androgenwirkung ist sicherlich auch die Ursache fuer die reduzierte Fertilitaet der Gesamtgruppe . Waehrend die sozialen Faehigkeiten der Patientinnen in der Regel sehr gut entwickelt waren , hatte die Mehrzahl der Frauen Probleme in den Bereichen sexuelle Identitaet und Partnerschaft . Dies fuehrte dazu , dass eine signifikant hoehere Zahl von Patientinnen alleinstehend und unverheiratet war , wobei bestehende Beziehungen eher stabiler und befriedigender waren als bei dem Kontrollkollektiv . Insgesamt war die Einstellung zur Sexualitaet konservativer . Der Prozentsatz von Frauen , die in einer gleichgeschlechtlichen Partnerbeziehung leben , ist nicht erhoeht . Eine maedchenspezifische Erziehung wurde von den Patientinnen ebenso wie von den Muettern verneint , allerdings hatte der groessere Teil der Frauen knabenspezifische Spiele bevorzugt . In Schulbildung und Beruf war kein Unterschied zur Kontrollgruppe zu sehen , die meisten Patientinnen waren als Angestellte in abhaengigem Arbeitsverhaeltnis taetig . Muetter wie Toechter waren mit der medizinischen Behandlung zufrieden , bedauerten allerdings , dass ihnen keine begleitende psychologische Betreuung angeboten worden war . Schlussfolgerung : Diese psychologischen Untersuchungen zeigen , dass erwachsene Frauen mit adrenogenitalem Syndrom gut mit der chronischen Erkrankung ebenso wie mit dem Trauma der Genitalfehlbildung zurechtkommen . Trotzdem bleiben Probleme in den sensitiven Bereichen der sexuellen Identifikation und geschlechtlichen Beziehungen .
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[ "umlsterm" ]
Syndrom is an umlsterm, Androgenexposition is an umlsterm, erwachsener is an umlsterm, Muetter is an umlsterm, Androgenkonzentration is an umlsterm, Therapie is an umlsterm, erwachsenen is an umlsterm, Frauen is an umlsterm, Methode is an umlsterm, Publikation is an umlsterm, Interviews is an umlsterm, erwachsene is an umlsterm, Frauen is an umlsterm, Syndrom is an umlsterm, Lebensqualitaet is an umlsterm, Selbstwahrnehmung is an umlsterm, Koerperwahrnehmung is an umlsterm, Sexualitaet is an umlsterm, Muetter is an umlsterm, Lebensqualitaet is an umlsterm, Interviews is an umlsterm, Erwachsenenalter is an umlsterm, androgenabhaengigen is an umlsterm, Androgenwirkung is an umlsterm, Fertilitaet is an umlsterm, Faehigkeiten is an umlsterm, Frauen is an umlsterm, Sexualitaet is an umlsterm, Frauen is an umlsterm, Muettern is an umlsterm, Frauen is an umlsterm, Beruf is an umlsterm, Muetter is an umlsterm, Behandlung is an umlsterm, erwachsene is an umlsterm, Frauen is an umlsterm, Syndrom is an umlsterm, Trauma is an umlsterm
MonatsschriftKinderheilkunde.71450815.ger.abstr_task1
Sentence: Fragestellung : Das adrenogenitale Syndrom auf Grund eines 21-Hydroxylasedefekts ist gekennzeichnet durch hohe prae- und postnatale Androgenexposition betroffener Maedchen . Eine Nachuntersuchung erwachsener Patientinnen und deren Muetter soll den Einfluss hoher Androgenkonzentration sowie den Effekt einer chronischen Erkrankung mit komplexer medikamentoeser und chirurgischer Therapie auf die sexuelle und psychosoziale Entwicklung der erwachsenen Frauen klaeren . Methode : Gegenstand dieser Publikation ist die Auswertung eines halbstandardisierten Interviews , in dem wir 45 erwachsene Frauen mit adrenogenitalem Syndrom , mit einem Durchschnittsalter von 27,0 +/- 6,64 Jahren , nach Anamnese , Lebensqualitaet , Selbstwahrnehmung , Koerperwahrnehmung , Sexualitaet und soziale Bindungen befragten . Ebenfalls befragt wurden 35 Muetter zu den Schwierigkeiten und Problemen , die sie mit der Erkrankung der Toechter hatten . Ergebnisse : Obwohl die Lebensqualitaet der Patientinnen insgesamt nicht eingeschraenkt war , zeigte die Auswertung dieser Interviews , dass ein grosser Prozentsatz , auch noch im Erwachsenenalter , an androgenabhaengigen Beschwerden wie Zyklusunregelmaessigkeiten und vermehrtem Haarwuchs , leidet . Eine vermehrte Androgenwirkung ist sicherlich auch die Ursache fuer die reduzierte Fertilitaet der Gesamtgruppe . Waehrend die sozialen Faehigkeiten der Patientinnen in der Regel sehr gut entwickelt waren , hatte die Mehrzahl der Frauen Probleme in den Bereichen sexuelle Identitaet und Partnerschaft . Dies fuehrte dazu , dass eine signifikant hoehere Zahl von Patientinnen alleinstehend und unverheiratet war , wobei bestehende Beziehungen eher stabiler und befriedigender waren als bei dem Kontrollkollektiv . Insgesamt war die Einstellung zur Sexualitaet konservativer . Der Prozentsatz von Frauen , die in einer gleichgeschlechtlichen Partnerbeziehung leben , ist nicht erhoeht . Eine maedchenspezifische Erziehung wurde von den Patientinnen ebenso wie von den Muettern verneint , allerdings hatte der groessere Teil der Frauen knabenspezifische Spiele bevorzugt . In Schulbildung und Beruf war kein Unterschied zur Kontrollgruppe zu sehen , die meisten Patientinnen waren als Angestellte in abhaengigem Arbeitsverhaeltnis taetig . Muetter wie Toechter waren mit der medizinischen Behandlung zufrieden , bedauerten allerdings , dass ihnen keine begleitende psychologische Betreuung angeboten worden war . Schlussfolgerung : Diese psychologischen Untersuchungen zeigen , dass erwachsene Frauen mit adrenogenitalem Syndrom gut mit der chronischen Erkrankung ebenso wie mit dem Trauma der Genitalfehlbildung zurechtkommen . Trotzdem bleiben Probleme in den sensitiven Bereichen der sexuellen Identifikation und geschlechtlichen Beziehungen . Instructions: please typing these entity words according to sentence: Syndrom, Androgenexposition, erwachsener, Muetter, Androgenkonzentration, Therapie, erwachsenen, Frauen, Methode, Publikation, Interviews, erwachsene, Frauen, Syndrom, Lebensqualitaet, Selbstwahrnehmung, Koerperwahrnehmung, Sexualitaet, Muetter, Lebensqualitaet, Interviews, Erwachsenenalter, androgenabhaengigen, Androgenwirkung, Fertilitaet, Faehigkeiten, Frauen, Sexualitaet, Frauen, Muettern, Frauen, Beruf, Muetter, Behandlung, erwachsene, Frauen, Syndrom, Trauma Options: umlsterm
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Fragestellung : Das adrenogenitale Syndrom auf Grund eines 21-Hydroxylasedefekts ist gekennzeichnet durch hohe prae- und postnatale Androgenexposition betroffener Maedchen . Eine Nachuntersuchung erwachsener Patientinnen und deren Muetter soll den Einfluss hoher Androgenkonzentration sowie den Effekt einer chronischen Erkrankung mit komplexer medikamentoeser und chirurgischer Therapie auf die sexuelle und psychosoziale Entwicklung der erwachsenen Frauen klaeren . Methode : Gegenstand dieser Publikation ist die Auswertung eines halbstandardisierten Interviews , in dem wir 45 erwachsene Frauen mit adrenogenitalem Syndrom , mit einem Durchschnittsalter von 27,0 +/- 6,64 Jahren , nach Anamnese , Lebensqualitaet , Selbstwahrnehmung , Koerperwahrnehmung , Sexualitaet und soziale Bindungen befragten . Ebenfalls befragt wurden 35 Muetter zu den Schwierigkeiten und Problemen , die sie mit der Erkrankung der Toechter hatten . Ergebnisse : Obwohl die Lebensqualitaet der Patientinnen insgesamt nicht eingeschraenkt war , zeigte die Auswertung dieser Interviews , dass ein grosser Prozentsatz , auch noch im Erwachsenenalter , an androgenabhaengigen Beschwerden wie Zyklusunregelmaessigkeiten und vermehrtem Haarwuchs , leidet . Eine vermehrte Androgenwirkung ist sicherlich auch die Ursache fuer die reduzierte Fertilitaet der Gesamtgruppe . Waehrend die sozialen Faehigkeiten der Patientinnen in der Regel sehr gut entwickelt waren , hatte die Mehrzahl der Frauen Probleme in den Bereichen sexuelle Identitaet und Partnerschaft . Dies fuehrte dazu , dass eine signifikant hoehere Zahl von Patientinnen alleinstehend und unverheiratet war , wobei bestehende Beziehungen eher stabiler und befriedigender waren als bei dem Kontrollkollektiv . Insgesamt war die Einstellung zur Sexualitaet konservativer . Der Prozentsatz von Frauen , die in einer gleichgeschlechtlichen Partnerbeziehung leben , ist nicht erhoeht . Eine maedchenspezifische Erziehung wurde von den Patientinnen ebenso wie von den Muettern verneint , allerdings hatte der groessere Teil der Frauen knabenspezifische Spiele bevorzugt . In Schulbildung und Beruf war kein Unterschied zur Kontrollgruppe zu sehen , die meisten Patientinnen waren als Angestellte in abhaengigem Arbeitsverhaeltnis taetig . Muetter wie Toechter waren mit der medizinischen Behandlung zufrieden , bedauerten allerdings , dass ihnen keine begleitende psychologische Betreuung angeboten worden war . Schlussfolgerung : Diese psychologischen Untersuchungen zeigen , dass erwachsene Frauen mit adrenogenitalem Syndrom gut mit der chronischen Erkrankung ebenso wie mit dem Trauma der Genitalfehlbildung zurechtkommen . Trotzdem bleiben Probleme in den sensitiven Bereichen der sexuellen Identifikation und geschlechtlichen Beziehungen .
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[ "umlsterm" ]
Syndrom, Androgenexposition, erwachsener, Muetter, Androgenkonzentration, Therapie, erwachsenen, Frauen, Methode, Publikation, Interviews, erwachsene, Frauen, Syndrom, Lebensqualitaet, Selbstwahrnehmung, Koerperwahrnehmung, Sexualitaet, Muetter, Lebensqualitaet, Interviews, Erwachsenenalter, androgenabhaengigen, Androgenwirkung, Fertilitaet, Faehigkeiten, Frauen, Sexualitaet, Frauen, Muettern, Frauen, Beruf, Muetter, Behandlung, erwachsene, Frauen, Syndrom, Trauma
MonatsschriftKinderheilkunde.71450815.ger.abstr_task2
Sentence: Fragestellung : Das adrenogenitale Syndrom auf Grund eines 21-Hydroxylasedefekts ist gekennzeichnet durch hohe prae- und postnatale Androgenexposition betroffener Maedchen . Eine Nachuntersuchung erwachsener Patientinnen und deren Muetter soll den Einfluss hoher Androgenkonzentration sowie den Effekt einer chronischen Erkrankung mit komplexer medikamentoeser und chirurgischer Therapie auf die sexuelle und psychosoziale Entwicklung der erwachsenen Frauen klaeren . Methode : Gegenstand dieser Publikation ist die Auswertung eines halbstandardisierten Interviews , in dem wir 45 erwachsene Frauen mit adrenogenitalem Syndrom , mit einem Durchschnittsalter von 27,0 +/- 6,64 Jahren , nach Anamnese , Lebensqualitaet , Selbstwahrnehmung , Koerperwahrnehmung , Sexualitaet und soziale Bindungen befragten . Ebenfalls befragt wurden 35 Muetter zu den Schwierigkeiten und Problemen , die sie mit der Erkrankung der Toechter hatten . Ergebnisse : Obwohl die Lebensqualitaet der Patientinnen insgesamt nicht eingeschraenkt war , zeigte die Auswertung dieser Interviews , dass ein grosser Prozentsatz , auch noch im Erwachsenenalter , an androgenabhaengigen Beschwerden wie Zyklusunregelmaessigkeiten und vermehrtem Haarwuchs , leidet . Eine vermehrte Androgenwirkung ist sicherlich auch die Ursache fuer die reduzierte Fertilitaet der Gesamtgruppe . Waehrend die sozialen Faehigkeiten der Patientinnen in der Regel sehr gut entwickelt waren , hatte die Mehrzahl der Frauen Probleme in den Bereichen sexuelle Identitaet und Partnerschaft . Dies fuehrte dazu , dass eine signifikant hoehere Zahl von Patientinnen alleinstehend und unverheiratet war , wobei bestehende Beziehungen eher stabiler und befriedigender waren als bei dem Kontrollkollektiv . Insgesamt war die Einstellung zur Sexualitaet konservativer . Der Prozentsatz von Frauen , die in einer gleichgeschlechtlichen Partnerbeziehung leben , ist nicht erhoeht . Eine maedchenspezifische Erziehung wurde von den Patientinnen ebenso wie von den Muettern verneint , allerdings hatte der groessere Teil der Frauen knabenspezifische Spiele bevorzugt . In Schulbildung und Beruf war kein Unterschied zur Kontrollgruppe zu sehen , die meisten Patientinnen waren als Angestellte in abhaengigem Arbeitsverhaeltnis taetig . Muetter wie Toechter waren mit der medizinischen Behandlung zufrieden , bedauerten allerdings , dass ihnen keine begleitende psychologische Betreuung angeboten worden war . Schlussfolgerung : Diese psychologischen Untersuchungen zeigen , dass erwachsene Frauen mit adrenogenitalem Syndrom gut mit der chronischen Erkrankung ebenso wie mit dem Trauma der Genitalfehlbildung zurechtkommen . Trotzdem bleiben Probleme in den sensitiven Bereichen der sexuellen Identifikation und geschlechtlichen Beziehungen . Instructions: please extract entity words from the input sentence
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Fragestellung : Das adrenogenitale Syndrom auf Grund eines 21-Hydroxylasedefekts ist gekennzeichnet durch hohe prae- und postnatale Androgenexposition betroffener Maedchen . Eine Nachuntersuchung erwachsener Patientinnen und deren Muetter soll den Einfluss hoher Androgenkonzentration sowie den Effekt einer chronischen Erkrankung mit komplexer medikamentoeser und chirurgischer Therapie auf die sexuelle und psychosoziale Entwicklung der erwachsenen Frauen klaeren . Methode : Gegenstand dieser Publikation ist die Auswertung eines halbstandardisierten Interviews , in dem wir 45 erwachsene Frauen mit adrenogenitalem Syndrom , mit einem Durchschnittsalter von 27,0 +/- 6,64 Jahren , nach Anamnese , Lebensqualitaet , Selbstwahrnehmung , Koerperwahrnehmung , Sexualitaet und soziale Bindungen befragten . Ebenfalls befragt wurden 35 Muetter zu den Schwierigkeiten und Problemen , die sie mit der Erkrankung der Toechter hatten . Ergebnisse : Obwohl die Lebensqualitaet der Patientinnen insgesamt nicht eingeschraenkt war , zeigte die Auswertung dieser Interviews , dass ein grosser Prozentsatz , auch noch im Erwachsenenalter , an androgenabhaengigen Beschwerden wie Zyklusunregelmaessigkeiten und vermehrtem Haarwuchs , leidet . Eine vermehrte Androgenwirkung ist sicherlich auch die Ursache fuer die reduzierte Fertilitaet der Gesamtgruppe . Waehrend die sozialen Faehigkeiten der Patientinnen in der Regel sehr gut entwickelt waren , hatte die Mehrzahl der Frauen Probleme in den Bereichen sexuelle Identitaet und Partnerschaft . Dies fuehrte dazu , dass eine signifikant hoehere Zahl von Patientinnen alleinstehend und unverheiratet war , wobei bestehende Beziehungen eher stabiler und befriedigender waren als bei dem Kontrollkollektiv . Insgesamt war die Einstellung zur Sexualitaet konservativer . Der Prozentsatz von Frauen , die in einer gleichgeschlechtlichen Partnerbeziehung leben , ist nicht erhoeht . Eine maedchenspezifische Erziehung wurde von den Patientinnen ebenso wie von den Muettern verneint , allerdings hatte der groessere Teil der Frauen knabenspezifische Spiele bevorzugt . In Schulbildung und Beruf war kein Unterschied zur Kontrollgruppe zu sehen , die meisten Patientinnen waren als Angestellte in abhaengigem Arbeitsverhaeltnis taetig . Muetter wie Toechter waren mit der medizinischen Behandlung zufrieden , bedauerten allerdings , dass ihnen keine begleitende psychologische Betreuung angeboten worden war . Schlussfolgerung : Diese psychologischen Untersuchungen zeigen , dass erwachsene Frauen mit adrenogenitalem Syndrom gut mit der chronischen Erkrankung ebenso wie mit dem Trauma der Genitalfehlbildung zurechtkommen . Trotzdem bleiben Probleme in den sensitiven Bereichen der sexuellen Identifikation und geschlechtlichen Beziehungen .
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[ "umlsterm" ]
H43Q mutation is a mutation, Csp is a protein, Hsc70 is a protein
1.0alpha7.train.706_task0
Sentence: Competition assays, tryptic digestion analyses, and direct binding analyses suggested that this was due to the H43Q mutation extensively reducing the affinity of binding of Csp to Hsc70. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: mutation, protein
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-mutation", "I-mutation", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein", "O" ]
Competition assays, tryptic digestion analyses, and direct binding analyses suggested that this was due to the H43Q mutation extensively reducing the affinity of binding of Csp to Hsc70.
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[ "mutation", "protein" ]
H43Q mutation is a mutation, Csp is a protein, Hsc70 is a protein
1.0alpha7.train.706_task1
Sentence: Competition assays, tryptic digestion analyses, and direct binding analyses suggested that this was due to the H43Q mutation extensively reducing the affinity of binding of Csp to Hsc70. Instructions: please typing these entity words according to sentence: H43Q mutation, Csp, Hsc70 Options: mutation, protein
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-mutation", "I-mutation", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein", "O" ]
Competition assays, tryptic digestion analyses, and direct binding analyses suggested that this was due to the H43Q mutation extensively reducing the affinity of binding of Csp to Hsc70.
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[ "mutation", "protein" ]
H43Q mutation, Csp, Hsc70
1.0alpha7.train.706_task2
Sentence: Competition assays, tryptic digestion analyses, and direct binding analyses suggested that this was due to the H43Q mutation extensively reducing the affinity of binding of Csp to Hsc70. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-mutation", "I-mutation", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "B-protein", "O" ]
Competition assays, tryptic digestion analyses, and direct binding analyses suggested that this was due to the H43Q mutation extensively reducing the affinity of binding of Csp to Hsc70.
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[ "mutation", "protein" ]
value is an umlsterm, cytogenetics is an umlsterm, histopathology is an umlsterm, patients is an umlsterm, myelodysplastic syndrome is an umlsterm, bone marrow cells is an umlsterm, diagnosis is an umlsterm, chromosome aberrations is an umlsterm, histopathological is an umlsterm, findings is an umlsterm, cell lines is an umlsterm, myelosclerosis is an umlsterm, survival is an umlsterm, patients is an umlsterm, cytogenetic analyses is an umlsterm, histopathological is an umlsterm, diagnoses is an umlsterm, developments is an umlsterm, cytogenetics is an umlsterm, cells is an umlsterm, tissue is an umlsterm, diagnosis is an umlsterm
DerPathologe.40150286.eng.abstr_task0
Sentence: The value of cytogenetics performed simultaneously with histopathology was evaluated in patients with myelodysplastic syndrome ( MDS ) . Clonal karyotype changes of the bone marrow cells supporting the histological diagnosis were found in 38/69 cases ( 55 % ) . The chromosome aberrations , especially complex changes , were significantly correlated to distinct histopathological findings such as atypias of the haematopoietic cell lines and myelosclerosis . Complex karyotype changes were further associated with short survival of the MDS patients . Our results demonstrate that cytogenetic analyses are helpful in supplementing the histopathological diagnoses . Recent developments in molecular cytogenetics even allow the detection of chromosomal aberrations in non-dividing cells from cytological preparations or tissue sections which may become available for routine diagnosis . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]
The value of cytogenetics performed simultaneously with histopathology was evaluated in patients with myelodysplastic syndrome ( MDS ) . Clonal karyotype changes of the bone marrow cells supporting the histological diagnosis were found in 38/69 cases ( 55 % ) . The chromosome aberrations , especially complex changes , were significantly correlated to distinct histopathological findings such as atypias of the haematopoietic cell lines and myelosclerosis . Complex karyotype changes were further associated with short survival of the MDS patients . Our results demonstrate that cytogenetic analyses are helpful in supplementing the histopathological diagnoses . Recent developments in molecular cytogenetics even allow the detection of chromosomal aberrations in non-dividing cells from cytological preparations or tissue sections which may become available for routine diagnosis .
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[ "umlsterm" ]
value is an umlsterm, cytogenetics is an umlsterm, histopathology is an umlsterm, patients is an umlsterm, myelodysplastic syndrome is an umlsterm, bone marrow cells is an umlsterm, diagnosis is an umlsterm, chromosome aberrations is an umlsterm, histopathological is an umlsterm, findings is an umlsterm, cell lines is an umlsterm, myelosclerosis is an umlsterm, survival is an umlsterm, patients is an umlsterm, cytogenetic analyses is an umlsterm, histopathological is an umlsterm, diagnoses is an umlsterm, developments is an umlsterm, cytogenetics is an umlsterm, cells is an umlsterm, tissue is an umlsterm, diagnosis is an umlsterm
DerPathologe.40150286.eng.abstr_task1
Sentence: The value of cytogenetics performed simultaneously with histopathology was evaluated in patients with myelodysplastic syndrome ( MDS ) . Clonal karyotype changes of the bone marrow cells supporting the histological diagnosis were found in 38/69 cases ( 55 % ) . The chromosome aberrations , especially complex changes , were significantly correlated to distinct histopathological findings such as atypias of the haematopoietic cell lines and myelosclerosis . Complex karyotype changes were further associated with short survival of the MDS patients . Our results demonstrate that cytogenetic analyses are helpful in supplementing the histopathological diagnoses . Recent developments in molecular cytogenetics even allow the detection of chromosomal aberrations in non-dividing cells from cytological preparations or tissue sections which may become available for routine diagnosis . Instructions: please typing these entity words according to sentence: value, cytogenetics, histopathology, patients, myelodysplastic syndrome, bone marrow cells, diagnosis, chromosome aberrations, histopathological, findings, cell lines, myelosclerosis, survival, patients, cytogenetic analyses, histopathological, diagnoses, developments, cytogenetics, cells, tissue, diagnosis Options: umlsterm
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The value of cytogenetics performed simultaneously with histopathology was evaluated in patients with myelodysplastic syndrome ( MDS ) . Clonal karyotype changes of the bone marrow cells supporting the histological diagnosis were found in 38/69 cases ( 55 % ) . The chromosome aberrations , especially complex changes , were significantly correlated to distinct histopathological findings such as atypias of the haematopoietic cell lines and myelosclerosis . Complex karyotype changes were further associated with short survival of the MDS patients . Our results demonstrate that cytogenetic analyses are helpful in supplementing the histopathological diagnoses . Recent developments in molecular cytogenetics even allow the detection of chromosomal aberrations in non-dividing cells from cytological preparations or tissue sections which may become available for routine diagnosis .
[ "The", "value", "of", "cytogenetics", "performed", "simultaneously", "with", "histopathology", "was", "evaluated", "in", "patients", "with", "myelodysplastic", "syndrome", "(", "MDS", ")", ".", "Clonal", "karyotype", "changes", "of", "the", "bone", "marrow", "cells", "supporting", "the", "histological", "diagnosis", "were", "found", "in", "38/69", "cases", "(", "55", "%", ")", ".", "The", "chromosome", "aberrations", ",", "especially", "complex", "changes", ",", "were", "significantly", "correlated", "to", "distinct", "histopathological", "findings", "such", "as", "atypias", "of", "the", "haematopoietic", "cell", "lines", "and", "myelosclerosis", ".", "Complex", "karyotype", "changes", "were", "further", "associated", "with", "short", "survival", "of", "the", "MDS", "patients", ".", "Our", "results", "demonstrate", "that", "cytogenetic", "analyses", "are", "helpful", "in", "supplementing", "the", "histopathological", "diagnoses", ".", "Recent", "developments", "in", "molecular", "cytogenetics", "even", "allow", "the", "detection", "of", "chromosomal", "aberrations", "in", "non", "-", "dividing", "cells", "from", "cytological", "preparations", "or", "tissue", "sections", "which", "may", "become", "available", "for", "routine", "diagnosis", "." ]
[ "umlsterm" ]
value, cytogenetics, histopathology, patients, myelodysplastic syndrome, bone marrow cells, diagnosis, chromosome aberrations, histopathological, findings, cell lines, myelosclerosis, survival, patients, cytogenetic analyses, histopathological, diagnoses, developments, cytogenetics, cells, tissue, diagnosis
DerPathologe.40150286.eng.abstr_task2
Sentence: The value of cytogenetics performed simultaneously with histopathology was evaluated in patients with myelodysplastic syndrome ( MDS ) . Clonal karyotype changes of the bone marrow cells supporting the histological diagnosis were found in 38/69 cases ( 55 % ) . The chromosome aberrations , especially complex changes , were significantly correlated to distinct histopathological findings such as atypias of the haematopoietic cell lines and myelosclerosis . Complex karyotype changes were further associated with short survival of the MDS patients . Our results demonstrate that cytogenetic analyses are helpful in supplementing the histopathological diagnoses . Recent developments in molecular cytogenetics even allow the detection of chromosomal aberrations in non-dividing cells from cytological preparations or tissue sections which may become available for routine diagnosis . Instructions: please extract entity words from the input sentence
[ "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]
The value of cytogenetics performed simultaneously with histopathology was evaluated in patients with myelodysplastic syndrome ( MDS ) . Clonal karyotype changes of the bone marrow cells supporting the histological diagnosis were found in 38/69 cases ( 55 % ) . The chromosome aberrations , especially complex changes , were significantly correlated to distinct histopathological findings such as atypias of the haematopoietic cell lines and myelosclerosis . Complex karyotype changes were further associated with short survival of the MDS patients . Our results demonstrate that cytogenetic analyses are helpful in supplementing the histopathological diagnoses . Recent developments in molecular cytogenetics even allow the detection of chromosomal aberrations in non-dividing cells from cytological preparations or tissue sections which may become available for routine diagnosis .
[ "The", "value", "of", "cytogenetics", "performed", "simultaneously", "with", "histopathology", "was", "evaluated", "in", "patients", "with", "myelodysplastic", "syndrome", "(", "MDS", ")", ".", "Clonal", "karyotype", "changes", "of", "the", "bone", "marrow", "cells", "supporting", "the", "histological", "diagnosis", "were", "found", "in", "38/69", "cases", "(", "55", "%", ")", ".", "The", "chromosome", "aberrations", ",", "especially", "complex", "changes", ",", "were", "significantly", "correlated", "to", "distinct", "histopathological", "findings", "such", "as", "atypias", "of", "the", "haematopoietic", "cell", "lines", "and", "myelosclerosis", ".", "Complex", "karyotype", "changes", "were", "further", "associated", "with", "short", "survival", "of", "the", "MDS", "patients", ".", "Our", "results", "demonstrate", "that", "cytogenetic", "analyses", "are", "helpful", "in", "supplementing", "the", "histopathological", "diagnoses", ".", "Recent", "developments", "in", "molecular", "cytogenetics", "even", "allow", "the", "detection", "of", "chromosomal", "aberrations", "in", "non", "-", "dividing", "cells", "from", "cytological", "preparations", "or", "tissue", "sections", "which", "may", "become", "available", "for", "routine", "diagnosis", "." ]
[ "umlsterm" ]
zevalin is a CHEMICAL, 90Y is a CHEMICAL, CD20 is a GENE-Y
10541376_task0
Sentence: Radioimmunotherapy of relapsed non-Hodgkin's lymphoma with zevalin, a 90Y-labeled anti-CD20 monoclonal antibody. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, CHEMICAL
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O" ]
Radioimmunotherapy of relapsed non-Hodgkin's lymphoma with zevalin, a 90Y-labeled anti-CD20 monoclonal antibody.
[ "Radioimmunotherapy", "of", "relapsed", "non", "-", "Hodgkin", "'s", "lymphoma", "with", "zevalin", ",", "a", "90Y", "-", "labeled", "anti", "-", "CD20", "monoclonal", "antibody", "." ]
[ "CHEMICAL", "GENE-Y" ]
zevalin is a CHEMICAL, 90Y is a CHEMICAL, CD20 is a GENE-Y
10541376_task1
Sentence: Radioimmunotherapy of relapsed non-Hodgkin's lymphoma with zevalin, a 90Y-labeled anti-CD20 monoclonal antibody. Instructions: please typing these entity words according to sentence: zevalin, 90Y, CD20 Options: GENE-Y, CHEMICAL
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O" ]
Radioimmunotherapy of relapsed non-Hodgkin's lymphoma with zevalin, a 90Y-labeled anti-CD20 monoclonal antibody.
[ "Radioimmunotherapy", "of", "relapsed", "non", "-", "Hodgkin", "'s", "lymphoma", "with", "zevalin", ",", "a", "90Y", "-", "labeled", "anti", "-", "CD20", "monoclonal", "antibody", "." ]
[ "CHEMICAL", "GENE-Y" ]
zevalin, 90Y, CD20
10541376_task2
Sentence: Radioimmunotherapy of relapsed non-Hodgkin's lymphoma with zevalin, a 90Y-labeled anti-CD20 monoclonal antibody. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O" ]
Radioimmunotherapy of relapsed non-Hodgkin's lymphoma with zevalin, a 90Y-labeled anti-CD20 monoclonal antibody.
[ "Radioimmunotherapy", "of", "relapsed", "non", "-", "Hodgkin", "'s", "lymphoma", "with", "zevalin", ",", "a", "90Y", "-", "labeled", "anti", "-", "CD20", "monoclonal", "antibody", "." ]
[ "CHEMICAL", "GENE-Y" ]
selamectin is a Intervention_Pharmacological, muris infection is a Outcome_Physical, Efficacy is a Outcome_Other, Fourty - eight is a Participant_Sample-size, S. muris - positive rats is a Participant_Condition, Selamectin is a Intervention_Pharmacological, effective ( based on egg per gram method ) in eliminating S. is a Outcome_Other, efficacy of the treatment is a Outcome_Other, male and female rats is a Participant_Sex
35910_task0
Sentence: Use of topical selamectin for the treatment of Syphacia muris infection in laboratory rats . Efficacy of selamectin was studied in naturally acquired S. muris infections in rats . Fourty-eight S. muris-positive rats were divided into six treated and two control groups . Selamectin ( 6 mg/kg ) was applied topically to the skin in a single spot at the base of the neck in the treatment group . The rats of treated and control groups were necropsied on the 24th day after the treatment . Topical selamectin was found to be 40.7-63.3 % effective ( based on egg per gram method ) in eliminating S. muris infection in rats . The efficacy of the treatment against S. muris ( based on adult worm counts ) in male and female rats was 35.14-58.88 % , respectively ( mean 48.39 % ) . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Participant_Condition, Participant_Sex, Outcome_Physical, Participant_Sample-size, Outcome_Other
[ "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sex", "I-Participant_Sex", "I-Participant_Sex", "I-Participant_Sex", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Use of topical selamectin for the treatment of Syphacia muris infection in laboratory rats . Efficacy of selamectin was studied in naturally acquired S. muris infections in rats . Fourty-eight S. muris-positive rats were divided into six treated and two control groups . Selamectin ( 6 mg/kg ) was applied topically to the skin in a single spot at the base of the neck in the treatment group . The rats of treated and control groups were necropsied on the 24th day after the treatment . Topical selamectin was found to be 40.7-63.3 % effective ( based on egg per gram method ) in eliminating S. muris infection in rats . The efficacy of the treatment against S. muris ( based on adult worm counts ) in male and female rats was 35.14-58.88 % , respectively ( mean 48.39 % ) .
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[ "Outcome_Other", "Participant_Condition", "Participant_Sex", "Outcome_Physical", "Participant_Sample-size", "Intervention_Pharmacological" ]
selamectin is a Intervention_Pharmacological, muris infection is a Outcome_Physical, Efficacy is a Outcome_Other, Fourty - eight is a Participant_Sample-size, S. muris - positive rats is a Participant_Condition, Selamectin is a Intervention_Pharmacological, effective ( based on egg per gram method ) in eliminating S. is a Outcome_Other, efficacy of the treatment is a Outcome_Other, male and female rats is a Participant_Sex
35910_task1
Sentence: Use of topical selamectin for the treatment of Syphacia muris infection in laboratory rats . Efficacy of selamectin was studied in naturally acquired S. muris infections in rats . Fourty-eight S. muris-positive rats were divided into six treated and two control groups . Selamectin ( 6 mg/kg ) was applied topically to the skin in a single spot at the base of the neck in the treatment group . The rats of treated and control groups were necropsied on the 24th day after the treatment . Topical selamectin was found to be 40.7-63.3 % effective ( based on egg per gram method ) in eliminating S. muris infection in rats . The efficacy of the treatment against S. muris ( based on adult worm counts ) in male and female rats was 35.14-58.88 % , respectively ( mean 48.39 % ) . Instructions: please typing these entity words according to sentence: selamectin, muris infection, Efficacy, Fourty - eight, S. muris - positive rats, Selamectin, effective ( based on egg per gram method ) in eliminating S., efficacy of the treatment, male and female rats Options: Intervention_Pharmacological, Participant_Condition, Participant_Sex, Outcome_Physical, Participant_Sample-size, Outcome_Other
[ "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sex", "I-Participant_Sex", "I-Participant_Sex", "I-Participant_Sex", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Use of topical selamectin for the treatment of Syphacia muris infection in laboratory rats . Efficacy of selamectin was studied in naturally acquired S. muris infections in rats . Fourty-eight S. muris-positive rats were divided into six treated and two control groups . Selamectin ( 6 mg/kg ) was applied topically to the skin in a single spot at the base of the neck in the treatment group . The rats of treated and control groups were necropsied on the 24th day after the treatment . Topical selamectin was found to be 40.7-63.3 % effective ( based on egg per gram method ) in eliminating S. muris infection in rats . The efficacy of the treatment against S. muris ( based on adult worm counts ) in male and female rats was 35.14-58.88 % , respectively ( mean 48.39 % ) .
[ "Use", "of", "topical", "selamectin", "for", "the", "treatment", "of", "Syphacia", "muris", "infection", "in", "laboratory", "rats", ".", "Efficacy", "of", "selamectin", "was", "studied", "in", "naturally", "acquired", "S.", "muris", "infections", "in", "rats", ".", "Fourty", "-", "eight", "S.", "muris", "-", "positive", "rats", "were", "divided", "into", "six", "treated", "and", "two", "control", "groups", ".", "Selamectin", "(", "6", "mg", "/", "kg", ")", "was", "applied", "topically", "to", "the", "skin", "in", "a", "single", "spot", "at", "the", "base", "of", "the", "neck", "in", "the", "treatment", "group", ".", "The", "rats", "of", "treated", "and", "control", "groups", "were", "necropsied", "on", "the", "24th", "day", "after", "the", "treatment", ".", "Topical", "selamectin", "was", "found", "to", "be", "40.7", "-", "63.3", "%", "effective", "(", "based", "on", "egg", "per", "gram", "method", ")", "in", "eliminating", "S.", "muris", "infection", "in", "rats", ".", "The", "efficacy", "of", "the", "treatment", "against", "S.", "muris", "(", "based", "on", "adult", "worm", "counts", ")", "in", "male", "and", "female", "rats", "was", "35.14", "-", "58.88", "%", ",", "respectively", "(", "mean", "48.39", "%", ")", "." ]
[ "Outcome_Other", "Participant_Condition", "Participant_Sex", "Outcome_Physical", "Participant_Sample-size", "Intervention_Pharmacological" ]
selamectin, muris infection, Efficacy, Fourty - eight, S. muris - positive rats, Selamectin, effective ( based on egg per gram method ) in eliminating S., efficacy of the treatment, male and female rats
35910_task2
Sentence: Use of topical selamectin for the treatment of Syphacia muris infection in laboratory rats . Efficacy of selamectin was studied in naturally acquired S. muris infections in rats . Fourty-eight S. muris-positive rats were divided into six treated and two control groups . Selamectin ( 6 mg/kg ) was applied topically to the skin in a single spot at the base of the neck in the treatment group . The rats of treated and control groups were necropsied on the 24th day after the treatment . Topical selamectin was found to be 40.7-63.3 % effective ( based on egg per gram method ) in eliminating S. muris infection in rats . The efficacy of the treatment against S. muris ( based on adult worm counts ) in male and female rats was 35.14-58.88 % , respectively ( mean 48.39 % ) . Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sex", "I-Participant_Sex", "I-Participant_Sex", "I-Participant_Sex", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]
Use of topical selamectin for the treatment of Syphacia muris infection in laboratory rats . Efficacy of selamectin was studied in naturally acquired S. muris infections in rats . Fourty-eight S. muris-positive rats were divided into six treated and two control groups . Selamectin ( 6 mg/kg ) was applied topically to the skin in a single spot at the base of the neck in the treatment group . The rats of treated and control groups were necropsied on the 24th day after the treatment . Topical selamectin was found to be 40.7-63.3 % effective ( based on egg per gram method ) in eliminating S. muris infection in rats . The efficacy of the treatment against S. muris ( based on adult worm counts ) in male and female rats was 35.14-58.88 % , respectively ( mean 48.39 % ) .
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[ "Outcome_Other", "Participant_Condition", "Participant_Sex", "Outcome_Physical", "Participant_Sample-size", "Intervention_Pharmacological" ]
Frizzled-2 is a Gene_or_gene_product, beta - catenin is a Gene_or_gene_product, Ca2 + is a Simple_chemical, Frizzled is a Gene_or_gene_product, Frizzled is a Gene_or_gene_product, intracellular is a Cellular_component, Wnt is a Gene_or_gene_product, Frizzled is a Gene_or_gene_product, Frizzled-2 is a Gene_or_gene_product, beta2-adrenergic receptor is a Gene_or_gene_product, Wnt-5a is a Gene_or_gene_product, Frizzled-2 is a Gene_or_gene_product, G proteins is a Gene_or_gene_product, Galpha(i ) is a Gene_or_gene_product, calcium is a Simple_chemical, intracellular stores is a Cellular_component, nuclear factor of activated T cells is a Gene_or_gene_product, beta - lactamase is a Gene_or_gene_product, Frizzled-2 is a Gene_or_gene_product, calcium is a Simple_chemical, Wnt-5a is a Gene_or_gene_product, Wnt-3a is a Gene_or_gene_product, Frizzled-2 is a Gene_or_gene_product, Wnt is a Gene_or_gene_product, Frizzled is a Gene_or_gene_product, beta - catenin is a Gene_or_gene_product, Frizzled is a Gene_or_gene_product, Frizzled-2 is a Gene_or_gene_product, Frizzled-1 is a Gene_or_gene_product, Wnt-3a is a Gene_or_gene_product, Wnt-3a is a Gene_or_gene_product, beta - lactamase is a Gene_or_gene_product, luciferase is a Gene_or_gene_product, Frizzled is a Gene_or_gene_product, Frizzled is a Gene_or_gene_product
191_task0
Sentence: Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2+-mobilization in Human Embryonic Kidney 293 cells. Signal transduction via the Frizzled family of seven-transmembrane receptors controls important developmental processes. Aberrant signaling caused by altered Frizzled receptor activity or by mutations in downstream signaling components has been implicated in several adult pathologies. A diverse array of intracellular signaling pathways has been suggested to transduce the signals exerted in cells when secreted ligands of the Wnt family bind to Frizzled receptors. Studies with a chimeric receptor composed of Frizzled-2 and the beta2-adrenergic receptor have suggested that the binding of Wnt-5a to Frizzled-2 results in the activation of G proteins of the Galpha(i) family, the mobilization of calcium from intracellular stores and the induction of gene transcription through nuclear factor of activated T cells. In this report, we demonstrate by using beta-lactamase reporter gene technology that full-length, wild-type human Frizzled-2 does not couple to calcium-mediated signaling in HEK293 cells following stimulation with purified recombinant mouse Wnt-5a. In contrast, when stimulated with recombinant mouse Wnt-3a, Frizzled-2 activates the canonical Wnt/Frizzled signaling pathway, involving the transcriptional modulator beta-catenin. Our report underlines the importance of using cell lines stably overexpressing wild-type Frizzled receptors and the use of purified ligands when studying receptor pharmacology. This approach has allowed us to measure the half-maximal concentration for activation of human Frizzled-2 (1.5+/-0.4 nM; avg.+/-SD) and human Frizzled-1 (1.3+/-0.5 nM) following stimulation by Wnt-3a. Our results suggest that there is receptor redundancy with regard to Wnt-3a reception. In addition, we introduce beta-lactamase reporter gene technology as an alternative to luciferase-based reporters to measure Frizzled receptor modulation for the discovery of Frizzled receptor-interacting drugs. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Simple_chemical, Gene_or_gene_product, Cellular_component
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Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2+-mobilization in Human Embryonic Kidney 293 cells. Signal transduction via the Frizzled family of seven-transmembrane receptors controls important developmental processes. Aberrant signaling caused by altered Frizzled receptor activity or by mutations in downstream signaling components has been implicated in several adult pathologies. A diverse array of intracellular signaling pathways has been suggested to transduce the signals exerted in cells when secreted ligands of the Wnt family bind to Frizzled receptors. Studies with a chimeric receptor composed of Frizzled-2 and the beta2-adrenergic receptor have suggested that the binding of Wnt-5a to Frizzled-2 results in the activation of G proteins of the Galpha(i) family, the mobilization of calcium from intracellular stores and the induction of gene transcription through nuclear factor of activated T cells. In this report, we demonstrate by using beta-lactamase reporter gene technology that full-length, wild-type human Frizzled-2 does not couple to calcium-mediated signaling in HEK293 cells following stimulation with purified recombinant mouse Wnt-5a. In contrast, when stimulated with recombinant mouse Wnt-3a, Frizzled-2 activates the canonical Wnt/Frizzled signaling pathway, involving the transcriptional modulator beta-catenin. Our report underlines the importance of using cell lines stably overexpressing wild-type Frizzled receptors and the use of purified ligands when studying receptor pharmacology. This approach has allowed us to measure the half-maximal concentration for activation of human Frizzled-2 (1.5+/-0.4 nM; avg.+/-SD) and human Frizzled-1 (1.3+/-0.5 nM) following stimulation by Wnt-3a. Our results suggest that there is receptor redundancy with regard to Wnt-3a reception. In addition, we introduce beta-lactamase reporter gene technology as an alternative to luciferase-based reporters to measure Frizzled receptor modulation for the discovery of Frizzled receptor-interacting drugs.
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[ "Gene_or_gene_product", "Cellular_component", "Simple_chemical" ]
Frizzled-2 is a Gene_or_gene_product, beta - catenin is a Gene_or_gene_product, Ca2 + is a Simple_chemical, Frizzled is a Gene_or_gene_product, Frizzled is a Gene_or_gene_product, intracellular is a Cellular_component, Wnt is a Gene_or_gene_product, Frizzled is a Gene_or_gene_product, Frizzled-2 is a Gene_or_gene_product, beta2-adrenergic receptor is a Gene_or_gene_product, Wnt-5a is a Gene_or_gene_product, Frizzled-2 is a Gene_or_gene_product, G proteins is a Gene_or_gene_product, Galpha(i ) is a Gene_or_gene_product, calcium is a Simple_chemical, intracellular stores is a Cellular_component, nuclear factor of activated T cells is a Gene_or_gene_product, beta - lactamase is a Gene_or_gene_product, Frizzled-2 is a Gene_or_gene_product, calcium is a Simple_chemical, Wnt-5a is a Gene_or_gene_product, Wnt-3a is a Gene_or_gene_product, Frizzled-2 is a Gene_or_gene_product, Wnt is a Gene_or_gene_product, Frizzled is a Gene_or_gene_product, beta - catenin is a Gene_or_gene_product, Frizzled is a Gene_or_gene_product, Frizzled-2 is a Gene_or_gene_product, Frizzled-1 is a Gene_or_gene_product, Wnt-3a is a Gene_or_gene_product, Wnt-3a is a Gene_or_gene_product, beta - lactamase is a Gene_or_gene_product, luciferase is a Gene_or_gene_product, Frizzled is a Gene_or_gene_product, Frizzled is a Gene_or_gene_product
191_task1
Sentence: Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2+-mobilization in Human Embryonic Kidney 293 cells. Signal transduction via the Frizzled family of seven-transmembrane receptors controls important developmental processes. Aberrant signaling caused by altered Frizzled receptor activity or by mutations in downstream signaling components has been implicated in several adult pathologies. A diverse array of intracellular signaling pathways has been suggested to transduce the signals exerted in cells when secreted ligands of the Wnt family bind to Frizzled receptors. Studies with a chimeric receptor composed of Frizzled-2 and the beta2-adrenergic receptor have suggested that the binding of Wnt-5a to Frizzled-2 results in the activation of G proteins of the Galpha(i) family, the mobilization of calcium from intracellular stores and the induction of gene transcription through nuclear factor of activated T cells. In this report, we demonstrate by using beta-lactamase reporter gene technology that full-length, wild-type human Frizzled-2 does not couple to calcium-mediated signaling in HEK293 cells following stimulation with purified recombinant mouse Wnt-5a. In contrast, when stimulated with recombinant mouse Wnt-3a, Frizzled-2 activates the canonical Wnt/Frizzled signaling pathway, involving the transcriptional modulator beta-catenin. Our report underlines the importance of using cell lines stably overexpressing wild-type Frizzled receptors and the use of purified ligands when studying receptor pharmacology. This approach has allowed us to measure the half-maximal concentration for activation of human Frizzled-2 (1.5+/-0.4 nM; avg.+/-SD) and human Frizzled-1 (1.3+/-0.5 nM) following stimulation by Wnt-3a. Our results suggest that there is receptor redundancy with regard to Wnt-3a reception. In addition, we introduce beta-lactamase reporter gene technology as an alternative to luciferase-based reporters to measure Frizzled receptor modulation for the discovery of Frizzled receptor-interacting drugs. Instructions: please typing these entity words according to sentence: Frizzled-2, beta - catenin, Ca2 +, Frizzled, Frizzled, intracellular, Wnt, Frizzled, Frizzled-2, beta2-adrenergic receptor, Wnt-5a, Frizzled-2, G proteins, Galpha(i ), calcium, intracellular stores, nuclear factor of activated T cells, beta - lactamase, Frizzled-2, calcium, Wnt-5a, Wnt-3a, Frizzled-2, Wnt, Frizzled, beta - catenin, Frizzled, Frizzled-2, Frizzled-1, Wnt-3a, Wnt-3a, beta - lactamase, luciferase, Frizzled, Frizzled Options: Simple_chemical, Gene_or_gene_product, Cellular_component
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Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2+-mobilization in Human Embryonic Kidney 293 cells. Signal transduction via the Frizzled family of seven-transmembrane receptors controls important developmental processes. Aberrant signaling caused by altered Frizzled receptor activity or by mutations in downstream signaling components has been implicated in several adult pathologies. A diverse array of intracellular signaling pathways has been suggested to transduce the signals exerted in cells when secreted ligands of the Wnt family bind to Frizzled receptors. Studies with a chimeric receptor composed of Frizzled-2 and the beta2-adrenergic receptor have suggested that the binding of Wnt-5a to Frizzled-2 results in the activation of G proteins of the Galpha(i) family, the mobilization of calcium from intracellular stores and the induction of gene transcription through nuclear factor of activated T cells. In this report, we demonstrate by using beta-lactamase reporter gene technology that full-length, wild-type human Frizzled-2 does not couple to calcium-mediated signaling in HEK293 cells following stimulation with purified recombinant mouse Wnt-5a. In contrast, when stimulated with recombinant mouse Wnt-3a, Frizzled-2 activates the canonical Wnt/Frizzled signaling pathway, involving the transcriptional modulator beta-catenin. Our report underlines the importance of using cell lines stably overexpressing wild-type Frizzled receptors and the use of purified ligands when studying receptor pharmacology. This approach has allowed us to measure the half-maximal concentration for activation of human Frizzled-2 (1.5+/-0.4 nM; avg.+/-SD) and human Frizzled-1 (1.3+/-0.5 nM) following stimulation by Wnt-3a. Our results suggest that there is receptor redundancy with regard to Wnt-3a reception. In addition, we introduce beta-lactamase reporter gene technology as an alternative to luciferase-based reporters to measure Frizzled receptor modulation for the discovery of Frizzled receptor-interacting drugs.
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[ "Gene_or_gene_product", "Cellular_component", "Simple_chemical" ]
Frizzled-2, beta - catenin, Ca2 +, Frizzled, Frizzled, intracellular, Wnt, Frizzled, Frizzled-2, beta2-adrenergic receptor, Wnt-5a, Frizzled-2, G proteins, Galpha(i ), calcium, intracellular stores, nuclear factor of activated T cells, beta - lactamase, Frizzled-2, calcium, Wnt-5a, Wnt-3a, Frizzled-2, Wnt, Frizzled, beta - catenin, Frizzled, Frizzled-2, Frizzled-1, Wnt-3a, Wnt-3a, beta - lactamase, luciferase, Frizzled, Frizzled
191_task2
Sentence: Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2+-mobilization in Human Embryonic Kidney 293 cells. Signal transduction via the Frizzled family of seven-transmembrane receptors controls important developmental processes. Aberrant signaling caused by altered Frizzled receptor activity or by mutations in downstream signaling components has been implicated in several adult pathologies. A diverse array of intracellular signaling pathways has been suggested to transduce the signals exerted in cells when secreted ligands of the Wnt family bind to Frizzled receptors. Studies with a chimeric receptor composed of Frizzled-2 and the beta2-adrenergic receptor have suggested that the binding of Wnt-5a to Frizzled-2 results in the activation of G proteins of the Galpha(i) family, the mobilization of calcium from intracellular stores and the induction of gene transcription through nuclear factor of activated T cells. In this report, we demonstrate by using beta-lactamase reporter gene technology that full-length, wild-type human Frizzled-2 does not couple to calcium-mediated signaling in HEK293 cells following stimulation with purified recombinant mouse Wnt-5a. In contrast, when stimulated with recombinant mouse Wnt-3a, Frizzled-2 activates the canonical Wnt/Frizzled signaling pathway, involving the transcriptional modulator beta-catenin. Our report underlines the importance of using cell lines stably overexpressing wild-type Frizzled receptors and the use of purified ligands when studying receptor pharmacology. This approach has allowed us to measure the half-maximal concentration for activation of human Frizzled-2 (1.5+/-0.4 nM; avg.+/-SD) and human Frizzled-1 (1.3+/-0.5 nM) following stimulation by Wnt-3a. Our results suggest that there is receptor redundancy with regard to Wnt-3a reception. In addition, we introduce beta-lactamase reporter gene technology as an alternative to luciferase-based reporters to measure Frizzled receptor modulation for the discovery of Frizzled receptor-interacting drugs. Instructions: please extract entity words from the input sentence
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Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2+-mobilization in Human Embryonic Kidney 293 cells. Signal transduction via the Frizzled family of seven-transmembrane receptors controls important developmental processes. Aberrant signaling caused by altered Frizzled receptor activity or by mutations in downstream signaling components has been implicated in several adult pathologies. A diverse array of intracellular signaling pathways has been suggested to transduce the signals exerted in cells when secreted ligands of the Wnt family bind to Frizzled receptors. Studies with a chimeric receptor composed of Frizzled-2 and the beta2-adrenergic receptor have suggested that the binding of Wnt-5a to Frizzled-2 results in the activation of G proteins of the Galpha(i) family, the mobilization of calcium from intracellular stores and the induction of gene transcription through nuclear factor of activated T cells. In this report, we demonstrate by using beta-lactamase reporter gene technology that full-length, wild-type human Frizzled-2 does not couple to calcium-mediated signaling in HEK293 cells following stimulation with purified recombinant mouse Wnt-5a. In contrast, when stimulated with recombinant mouse Wnt-3a, Frizzled-2 activates the canonical Wnt/Frizzled signaling pathway, involving the transcriptional modulator beta-catenin. Our report underlines the importance of using cell lines stably overexpressing wild-type Frizzled receptors and the use of purified ligands when studying receptor pharmacology. This approach has allowed us to measure the half-maximal concentration for activation of human Frizzled-2 (1.5+/-0.4 nM; avg.+/-SD) and human Frizzled-1 (1.3+/-0.5 nM) following stimulation by Wnt-3a. Our results suggest that there is receptor redundancy with regard to Wnt-3a reception. In addition, we introduce beta-lactamase reporter gene technology as an alternative to luciferase-based reporters to measure Frizzled receptor modulation for the discovery of Frizzled receptor-interacting drugs.
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[ "Gene_or_gene_product", "Cellular_component", "Simple_chemical" ]
radiotherapy is a Intervention_Physical, cisplatin is a Intervention_Pharmacological, paclitaxel is a Intervention_Pharmacological, advanced cervical cancer is a Participant_Condition, standard radiotherapy is a Intervention_Physical, advanced cervical carcinoma is a Participant_Condition, 31 is a Participant_Sample-size, FIGO stage IB2-IVA cervical cancer or with postsurgical pelvic recurrence is a Participant_Condition
47565_task0
Sentence: A phase II randomized trial comparing radiotherapy with concurrent weekly cisplatin or weekly paclitaxel in patients with advanced cervical cancer . PURPOSE/OBJECTIVE This is a prospective comparison of weekly cisplatin to weekly paclitaxel as concurrent chemotherapy with standard radiotherapy for locally advanced cervical carcinoma . MATERIALS/METHODS Between May 2000 and May 2004 , 31 women with FIGO stage IB2-IVA cervical cancer or with postsurgical pelvic recurrence were enrolled into this phase II study and randomized to receive on a weekly basis either 40 mg/m² Cisplatin ( group I ; 16 patients ) or 50 mg/m² paclitaxel ( group II ; 15 patients ) concurrently with radiotherapy . Median total dose to point A was 74 Gy ( range : 66-92 Gy ) for group I and 66 Gy ( range : 40-98 Gy ) for group II . Median follow-up time was 46 months . RESULTS Patient and tumor characteristics were similar in both groups . The mean number of chemotherapy cycles was also comparable with 87 % and 80 % of patients receiving at least 4 doses in groups I and II , respectively . Seven patients ( 44 % ) of group I and 8 patients ( 53 % ) of group II developed tumor recurrence . The Median Survival time was not reached for Group I and 53 months for group II . The proportion of patients surviving at 2 and 5 years was 78 % and 54 % for group I and 73 % and 43 % for group II respectively . CONCLUSIONS This small prospective study shows that weekly paclitaxel does not provide any clinical advantage over weekly cisplatin for concurrent chemoradiation for advanced carcinoma of the cervix . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Physical, Intervention_Pharmacological, Participant_Condition, Participant_Sample-size
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A phase II randomized trial comparing radiotherapy with concurrent weekly cisplatin or weekly paclitaxel in patients with advanced cervical cancer . PURPOSE/OBJECTIVE This is a prospective comparison of weekly cisplatin to weekly paclitaxel as concurrent chemotherapy with standard radiotherapy for locally advanced cervical carcinoma . MATERIALS/METHODS Between May 2000 and May 2004 , 31 women with FIGO stage IB2-IVA cervical cancer or with postsurgical pelvic recurrence were enrolled into this phase II study and randomized to receive on a weekly basis either 40 mg/m² Cisplatin ( group I ; 16 patients ) or 50 mg/m² paclitaxel ( group II ; 15 patients ) concurrently with radiotherapy . Median total dose to point A was 74 Gy ( range : 66-92 Gy ) for group I and 66 Gy ( range : 40-98 Gy ) for group II . Median follow-up time was 46 months . RESULTS Patient and tumor characteristics were similar in both groups . The mean number of chemotherapy cycles was also comparable with 87 % and 80 % of patients receiving at least 4 doses in groups I and II , respectively . Seven patients ( 44 % ) of group I and 8 patients ( 53 % ) of group II developed tumor recurrence . The Median Survival time was not reached for Group I and 53 months for group II . The proportion of patients surviving at 2 and 5 years was 78 % and 54 % for group I and 73 % and 43 % for group II respectively . CONCLUSIONS This small prospective study shows that weekly paclitaxel does not provide any clinical advantage over weekly cisplatin for concurrent chemoradiation for advanced carcinoma of the cervix .
[ "A", "phase", "II", "randomized", "trial", "comparing", "radiotherapy", "with", "concurrent", "weekly", "cisplatin", "or", "weekly", "paclitaxel", "in", "patients", "with", "advanced", "cervical", "cancer", ".", "PURPOSE", "/", "OBJECTIVE", "This", "is", "a", "prospective", "comparison", "of", "weekly", "cisplatin", "to", "weekly", "paclitaxel", "as", "concurrent", "chemotherapy", "with", "standard", "radiotherapy", "for", "locally", "advanced", "cervical", "carcinoma", ".", "MATERIALS", "/", "METHODS", "Between", "May", "2000", "and", "May", "2004", ",", "31", "women", "with", "FIGO", "stage", "IB2-IVA", "cervical", "cancer", "or", "with", "postsurgical", "pelvic", "recurrence", "were", "enrolled", "into", "this", "phase", "II", "study", "and", "randomized", "to", "receive", "on", "a", "weekly", "basis", "either", "40", "mg", "/", "m²", "Cisplatin", "(", "group", "I", ";", "16", "patients", ")", "or", "50", "mg", "/", "m²", "paclitaxel", "(", "group", "II", ";", "15", "patients", ")", "concurrently", "with", "radiotherapy", ".", "Median", "total", "dose", "to", "point", "A", "was", "74", "Gy", "(", "range", ":", "66", "-", "92", "Gy", ")", "for", "group", "I", "and", "66", "Gy", "(", "range", ":", "40", "-", "98", "Gy", ")", "for", "group", "II", ".", "Median", "follow", "-", "up", "time", "was", "46", "months", ".", "RESULTS", "Patient", "and", "tumor", "characteristics", "were", "similar", "in", "both", "groups", ".", "The", "mean", "number", "of", "chemotherapy", "cycles", "was", "also", "comparable", "with", "87", "%", "and", "80", "%", "of", "patients", "receiving", "at", "least", "4", "doses", "in", "groups", "I", "and", "II", ",", "respectively", ".", "Seven", "patients", "(", "44", "%", ")", "of", "group", "I", "and", "8", "patients", "(", "53", "%", ")", "of", "group", "II", "developed", "tumor", "recurrence", ".", "The", "Median", "Survival", "time", "was", "not", "reached", "for", "Group", "I", "and", "53", "months", "for", "group", "II", ".", "The", "proportion", "of", "patients", "surviving", "at", "2", "and", "5", "years", "was", "78", "%", "and", "54", "%", "for", "group", "I", "and", "73", "%", "and", "43", "%", "for", "group", "II", "respectively", ".", "CONCLUSIONS", "This", "small", "prospective", "study", "shows", "that", "weekly", "paclitaxel", "does", "not", "provide", "any", "clinical", "advantage", "over", "weekly", "cisplatin", "for", "concurrent", "chemoradiation", "for", "advanced", "carcinoma", "of", "the", "cervix", "." ]
[ "Participant_Condition", "Intervention_Physical", "Intervention_Pharmacological", "Participant_Sample-size" ]
radiotherapy is a Intervention_Physical, cisplatin is a Intervention_Pharmacological, paclitaxel is a Intervention_Pharmacological, advanced cervical cancer is a Participant_Condition, standard radiotherapy is a Intervention_Physical, advanced cervical carcinoma is a Participant_Condition, 31 is a Participant_Sample-size, FIGO stage IB2-IVA cervical cancer or with postsurgical pelvic recurrence is a Participant_Condition
47565_task1
Sentence: A phase II randomized trial comparing radiotherapy with concurrent weekly cisplatin or weekly paclitaxel in patients with advanced cervical cancer . PURPOSE/OBJECTIVE This is a prospective comparison of weekly cisplatin to weekly paclitaxel as concurrent chemotherapy with standard radiotherapy for locally advanced cervical carcinoma . MATERIALS/METHODS Between May 2000 and May 2004 , 31 women with FIGO stage IB2-IVA cervical cancer or with postsurgical pelvic recurrence were enrolled into this phase II study and randomized to receive on a weekly basis either 40 mg/m² Cisplatin ( group I ; 16 patients ) or 50 mg/m² paclitaxel ( group II ; 15 patients ) concurrently with radiotherapy . Median total dose to point A was 74 Gy ( range : 66-92 Gy ) for group I and 66 Gy ( range : 40-98 Gy ) for group II . Median follow-up time was 46 months . RESULTS Patient and tumor characteristics were similar in both groups . The mean number of chemotherapy cycles was also comparable with 87 % and 80 % of patients receiving at least 4 doses in groups I and II , respectively . Seven patients ( 44 % ) of group I and 8 patients ( 53 % ) of group II developed tumor recurrence . The Median Survival time was not reached for Group I and 53 months for group II . The proportion of patients surviving at 2 and 5 years was 78 % and 54 % for group I and 73 % and 43 % for group II respectively . CONCLUSIONS This small prospective study shows that weekly paclitaxel does not provide any clinical advantage over weekly cisplatin for concurrent chemoradiation for advanced carcinoma of the cervix . Instructions: please typing these entity words according to sentence: radiotherapy, cisplatin, paclitaxel, advanced cervical cancer, standard radiotherapy, advanced cervical carcinoma, 31, FIGO stage IB2-IVA cervical cancer or with postsurgical pelvic recurrence Options: Intervention_Physical, Intervention_Pharmacological, Participant_Condition, Participant_Sample-size
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A phase II randomized trial comparing radiotherapy with concurrent weekly cisplatin or weekly paclitaxel in patients with advanced cervical cancer . PURPOSE/OBJECTIVE This is a prospective comparison of weekly cisplatin to weekly paclitaxel as concurrent chemotherapy with standard radiotherapy for locally advanced cervical carcinoma . MATERIALS/METHODS Between May 2000 and May 2004 , 31 women with FIGO stage IB2-IVA cervical cancer or with postsurgical pelvic recurrence were enrolled into this phase II study and randomized to receive on a weekly basis either 40 mg/m² Cisplatin ( group I ; 16 patients ) or 50 mg/m² paclitaxel ( group II ; 15 patients ) concurrently with radiotherapy . Median total dose to point A was 74 Gy ( range : 66-92 Gy ) for group I and 66 Gy ( range : 40-98 Gy ) for group II . Median follow-up time was 46 months . RESULTS Patient and tumor characteristics were similar in both groups . The mean number of chemotherapy cycles was also comparable with 87 % and 80 % of patients receiving at least 4 doses in groups I and II , respectively . Seven patients ( 44 % ) of group I and 8 patients ( 53 % ) of group II developed tumor recurrence . The Median Survival time was not reached for Group I and 53 months for group II . The proportion of patients surviving at 2 and 5 years was 78 % and 54 % for group I and 73 % and 43 % for group II respectively . CONCLUSIONS This small prospective study shows that weekly paclitaxel does not provide any clinical advantage over weekly cisplatin for concurrent chemoradiation for advanced carcinoma of the cervix .
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[ "Participant_Condition", "Intervention_Physical", "Intervention_Pharmacological", "Participant_Sample-size" ]
radiotherapy, cisplatin, paclitaxel, advanced cervical cancer, standard radiotherapy, advanced cervical carcinoma, 31, FIGO stage IB2-IVA cervical cancer or with postsurgical pelvic recurrence
47565_task2
Sentence: A phase II randomized trial comparing radiotherapy with concurrent weekly cisplatin or weekly paclitaxel in patients with advanced cervical cancer . PURPOSE/OBJECTIVE This is a prospective comparison of weekly cisplatin to weekly paclitaxel as concurrent chemotherapy with standard radiotherapy for locally advanced cervical carcinoma . MATERIALS/METHODS Between May 2000 and May 2004 , 31 women with FIGO stage IB2-IVA cervical cancer or with postsurgical pelvic recurrence were enrolled into this phase II study and randomized to receive on a weekly basis either 40 mg/m² Cisplatin ( group I ; 16 patients ) or 50 mg/m² paclitaxel ( group II ; 15 patients ) concurrently with radiotherapy . Median total dose to point A was 74 Gy ( range : 66-92 Gy ) for group I and 66 Gy ( range : 40-98 Gy ) for group II . Median follow-up time was 46 months . RESULTS Patient and tumor characteristics were similar in both groups . The mean number of chemotherapy cycles was also comparable with 87 % and 80 % of patients receiving at least 4 doses in groups I and II , respectively . Seven patients ( 44 % ) of group I and 8 patients ( 53 % ) of group II developed tumor recurrence . The Median Survival time was not reached for Group I and 53 months for group II . The proportion of patients surviving at 2 and 5 years was 78 % and 54 % for group I and 73 % and 43 % for group II respectively . CONCLUSIONS This small prospective study shows that weekly paclitaxel does not provide any clinical advantage over weekly cisplatin for concurrent chemoradiation for advanced carcinoma of the cervix . Instructions: please extract entity words from the input sentence
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A phase II randomized trial comparing radiotherapy with concurrent weekly cisplatin or weekly paclitaxel in patients with advanced cervical cancer . PURPOSE/OBJECTIVE This is a prospective comparison of weekly cisplatin to weekly paclitaxel as concurrent chemotherapy with standard radiotherapy for locally advanced cervical carcinoma . MATERIALS/METHODS Between May 2000 and May 2004 , 31 women with FIGO stage IB2-IVA cervical cancer or with postsurgical pelvic recurrence were enrolled into this phase II study and randomized to receive on a weekly basis either 40 mg/m² Cisplatin ( group I ; 16 patients ) or 50 mg/m² paclitaxel ( group II ; 15 patients ) concurrently with radiotherapy . Median total dose to point A was 74 Gy ( range : 66-92 Gy ) for group I and 66 Gy ( range : 40-98 Gy ) for group II . Median follow-up time was 46 months . RESULTS Patient and tumor characteristics were similar in both groups . The mean number of chemotherapy cycles was also comparable with 87 % and 80 % of patients receiving at least 4 doses in groups I and II , respectively . Seven patients ( 44 % ) of group I and 8 patients ( 53 % ) of group II developed tumor recurrence . The Median Survival time was not reached for Group I and 53 months for group II . The proportion of patients surviving at 2 and 5 years was 78 % and 54 % for group I and 73 % and 43 % for group II respectively . CONCLUSIONS This small prospective study shows that weekly paclitaxel does not provide any clinical advantage over weekly cisplatin for concurrent chemoradiation for advanced carcinoma of the cervix .
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[ "Participant_Condition", "Intervention_Physical", "Intervention_Pharmacological", "Participant_Sample-size" ]
I kappa B alpha is a Protein, I kappa B alpha is a Protein, I kappa B alpha is a Protein, I kappa B alpha is a Protein, I kappa B alpha is a Protein, tumor necrosis factor alpha is a Protein, TNF - alpha is a Protein, I kappa B alpha is a Protein, TNF - alpha is a Protein, I kappa B alpha is a Protein, I kappa B alpha is a Protein, TNF - alpha is a Protein, I kappa B alpha is a Protein, I kappa B alpha is a Protein, I kappa B alpha is a Protein, TNF - alpha is a Protein, I kappa B alpha is a Protein
395_task0
Sentence: Activation of NF-kappa B by phosphatase inhibitors involves the phosphorylation of I kappa B alpha at phosphatase 2A-sensitive sites. Activation of NF-kappa B by various cellular stimuli involves the phosphorylation and subsequent degradation of its inhibitor, I kappa B alpha, although the underlying mechanism remains unclear. In the present study, the role of serine/threonine phosphatases in the regulation of I kappa B alpha phosphorylation was investigated. Our studies demonstrate that incubation of human T cells with low concentrations (approximately 1-5 nM) of calyculin A or okadaic acid, potent inhibitors of protein phosphatase type 1 (PP-1) and type 2A (PP-2A), induces the phosphorylation of I kappa B alpha even in the absence of any cellular stimulus. This action of the phosphatase inhibitors, which is associated with the activation of the RelA.p50 NF-kappa B heterodimer, is not affected by agents that block the induction of I kappa B alpha phosphorylation by tumor necrosis factor alpha (TNF-alpha). Furthermore, the phosphorylated I kappa B alpha from calyculin A-treated cells, but not that from TNF-alpha-stimulated cells, is sensitive to PP-2A in vitro, suggesting the existence of fundamental differences in the phosphorylation of I kappa B alpha induced by the two different NF-kappa B inducers. However, induction of I kappa B alpha phosphorylation by both TNF-alpha and the phosphatase inhibitors is associated with the subsequent degradation of I kappa B alpha. We further demonstrate that TNF-alpha- and calyculin A-induced I kappa B alpha degradation exhibits similar but not identical sensitivities to a proteasome inhibitor. Together, these results suggest that phosphorylation of I kappa B alpha, mediated through both the TNF-alpha-inducible and the PP-2A-opposing kinases, may serve to target I kappa B alpha for proteasome-mediated degradation. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein
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Activation of NF-kappa B by phosphatase inhibitors involves the phosphorylation of I kappa B alpha at phosphatase 2A-sensitive sites. Activation of NF-kappa B by various cellular stimuli involves the phosphorylation and subsequent degradation of its inhibitor, I kappa B alpha, although the underlying mechanism remains unclear. In the present study, the role of serine/threonine phosphatases in the regulation of I kappa B alpha phosphorylation was investigated. Our studies demonstrate that incubation of human T cells with low concentrations (approximately 1-5 nM) of calyculin A or okadaic acid, potent inhibitors of protein phosphatase type 1 (PP-1) and type 2A (PP-2A), induces the phosphorylation of I kappa B alpha even in the absence of any cellular stimulus. This action of the phosphatase inhibitors, which is associated with the activation of the RelA.p50 NF-kappa B heterodimer, is not affected by agents that block the induction of I kappa B alpha phosphorylation by tumor necrosis factor alpha (TNF-alpha). Furthermore, the phosphorylated I kappa B alpha from calyculin A-treated cells, but not that from TNF-alpha-stimulated cells, is sensitive to PP-2A in vitro, suggesting the existence of fundamental differences in the phosphorylation of I kappa B alpha induced by the two different NF-kappa B inducers. However, induction of I kappa B alpha phosphorylation by both TNF-alpha and the phosphatase inhibitors is associated with the subsequent degradation of I kappa B alpha. We further demonstrate that TNF-alpha- and calyculin A-induced I kappa B alpha degradation exhibits similar but not identical sensitivities to a proteasome inhibitor. Together, these results suggest that phosphorylation of I kappa B alpha, mediated through both the TNF-alpha-inducible and the PP-2A-opposing kinases, may serve to target I kappa B alpha for proteasome-mediated degradation.
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[ "Protein" ]
I kappa B alpha is a Protein, I kappa B alpha is a Protein, I kappa B alpha is a Protein, I kappa B alpha is a Protein, I kappa B alpha is a Protein, tumor necrosis factor alpha is a Protein, TNF - alpha is a Protein, I kappa B alpha is a Protein, TNF - alpha is a Protein, I kappa B alpha is a Protein, I kappa B alpha is a Protein, TNF - alpha is a Protein, I kappa B alpha is a Protein, I kappa B alpha is a Protein, I kappa B alpha is a Protein, TNF - alpha is a Protein, I kappa B alpha is a Protein
395_task1
Sentence: Activation of NF-kappa B by phosphatase inhibitors involves the phosphorylation of I kappa B alpha at phosphatase 2A-sensitive sites. Activation of NF-kappa B by various cellular stimuli involves the phosphorylation and subsequent degradation of its inhibitor, I kappa B alpha, although the underlying mechanism remains unclear. In the present study, the role of serine/threonine phosphatases in the regulation of I kappa B alpha phosphorylation was investigated. Our studies demonstrate that incubation of human T cells with low concentrations (approximately 1-5 nM) of calyculin A or okadaic acid, potent inhibitors of protein phosphatase type 1 (PP-1) and type 2A (PP-2A), induces the phosphorylation of I kappa B alpha even in the absence of any cellular stimulus. This action of the phosphatase inhibitors, which is associated with the activation of the RelA.p50 NF-kappa B heterodimer, is not affected by agents that block the induction of I kappa B alpha phosphorylation by tumor necrosis factor alpha (TNF-alpha). Furthermore, the phosphorylated I kappa B alpha from calyculin A-treated cells, but not that from TNF-alpha-stimulated cells, is sensitive to PP-2A in vitro, suggesting the existence of fundamental differences in the phosphorylation of I kappa B alpha induced by the two different NF-kappa B inducers. However, induction of I kappa B alpha phosphorylation by both TNF-alpha and the phosphatase inhibitors is associated with the subsequent degradation of I kappa B alpha. We further demonstrate that TNF-alpha- and calyculin A-induced I kappa B alpha degradation exhibits similar but not identical sensitivities to a proteasome inhibitor. Together, these results suggest that phosphorylation of I kappa B alpha, mediated through both the TNF-alpha-inducible and the PP-2A-opposing kinases, may serve to target I kappa B alpha for proteasome-mediated degradation. Instructions: please typing these entity words according to sentence: I kappa B alpha, I kappa B alpha, I kappa B alpha, I kappa B alpha, I kappa B alpha, tumor necrosis factor alpha, TNF - alpha, I kappa B alpha, TNF - alpha, I kappa B alpha, I kappa B alpha, TNF - alpha, I kappa B alpha, I kappa B alpha, I kappa B alpha, TNF - alpha, I kappa B alpha Options: Protein
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Activation of NF-kappa B by phosphatase inhibitors involves the phosphorylation of I kappa B alpha at phosphatase 2A-sensitive sites. Activation of NF-kappa B by various cellular stimuli involves the phosphorylation and subsequent degradation of its inhibitor, I kappa B alpha, although the underlying mechanism remains unclear. In the present study, the role of serine/threonine phosphatases in the regulation of I kappa B alpha phosphorylation was investigated. Our studies demonstrate that incubation of human T cells with low concentrations (approximately 1-5 nM) of calyculin A or okadaic acid, potent inhibitors of protein phosphatase type 1 (PP-1) and type 2A (PP-2A), induces the phosphorylation of I kappa B alpha even in the absence of any cellular stimulus. This action of the phosphatase inhibitors, which is associated with the activation of the RelA.p50 NF-kappa B heterodimer, is not affected by agents that block the induction of I kappa B alpha phosphorylation by tumor necrosis factor alpha (TNF-alpha). Furthermore, the phosphorylated I kappa B alpha from calyculin A-treated cells, but not that from TNF-alpha-stimulated cells, is sensitive to PP-2A in vitro, suggesting the existence of fundamental differences in the phosphorylation of I kappa B alpha induced by the two different NF-kappa B inducers. However, induction of I kappa B alpha phosphorylation by both TNF-alpha and the phosphatase inhibitors is associated with the subsequent degradation of I kappa B alpha. We further demonstrate that TNF-alpha- and calyculin A-induced I kappa B alpha degradation exhibits similar but not identical sensitivities to a proteasome inhibitor. Together, these results suggest that phosphorylation of I kappa B alpha, mediated through both the TNF-alpha-inducible and the PP-2A-opposing kinases, may serve to target I kappa B alpha for proteasome-mediated degradation.
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[ "Protein" ]
I kappa B alpha, I kappa B alpha, I kappa B alpha, I kappa B alpha, I kappa B alpha, tumor necrosis factor alpha, TNF - alpha, I kappa B alpha, TNF - alpha, I kappa B alpha, I kappa B alpha, TNF - alpha, I kappa B alpha, I kappa B alpha, I kappa B alpha, TNF - alpha, I kappa B alpha
395_task2
Sentence: Activation of NF-kappa B by phosphatase inhibitors involves the phosphorylation of I kappa B alpha at phosphatase 2A-sensitive sites. Activation of NF-kappa B by various cellular stimuli involves the phosphorylation and subsequent degradation of its inhibitor, I kappa B alpha, although the underlying mechanism remains unclear. In the present study, the role of serine/threonine phosphatases in the regulation of I kappa B alpha phosphorylation was investigated. Our studies demonstrate that incubation of human T cells with low concentrations (approximately 1-5 nM) of calyculin A or okadaic acid, potent inhibitors of protein phosphatase type 1 (PP-1) and type 2A (PP-2A), induces the phosphorylation of I kappa B alpha even in the absence of any cellular stimulus. This action of the phosphatase inhibitors, which is associated with the activation of the RelA.p50 NF-kappa B heterodimer, is not affected by agents that block the induction of I kappa B alpha phosphorylation by tumor necrosis factor alpha (TNF-alpha). Furthermore, the phosphorylated I kappa B alpha from calyculin A-treated cells, but not that from TNF-alpha-stimulated cells, is sensitive to PP-2A in vitro, suggesting the existence of fundamental differences in the phosphorylation of I kappa B alpha induced by the two different NF-kappa B inducers. However, induction of I kappa B alpha phosphorylation by both TNF-alpha and the phosphatase inhibitors is associated with the subsequent degradation of I kappa B alpha. We further demonstrate that TNF-alpha- and calyculin A-induced I kappa B alpha degradation exhibits similar but not identical sensitivities to a proteasome inhibitor. Together, these results suggest that phosphorylation of I kappa B alpha, mediated through both the TNF-alpha-inducible and the PP-2A-opposing kinases, may serve to target I kappa B alpha for proteasome-mediated degradation. Instructions: please extract entity words from the input sentence
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Activation of NF-kappa B by phosphatase inhibitors involves the phosphorylation of I kappa B alpha at phosphatase 2A-sensitive sites. Activation of NF-kappa B by various cellular stimuli involves the phosphorylation and subsequent degradation of its inhibitor, I kappa B alpha, although the underlying mechanism remains unclear. In the present study, the role of serine/threonine phosphatases in the regulation of I kappa B alpha phosphorylation was investigated. Our studies demonstrate that incubation of human T cells with low concentrations (approximately 1-5 nM) of calyculin A or okadaic acid, potent inhibitors of protein phosphatase type 1 (PP-1) and type 2A (PP-2A), induces the phosphorylation of I kappa B alpha even in the absence of any cellular stimulus. This action of the phosphatase inhibitors, which is associated with the activation of the RelA.p50 NF-kappa B heterodimer, is not affected by agents that block the induction of I kappa B alpha phosphorylation by tumor necrosis factor alpha (TNF-alpha). Furthermore, the phosphorylated I kappa B alpha from calyculin A-treated cells, but not that from TNF-alpha-stimulated cells, is sensitive to PP-2A in vitro, suggesting the existence of fundamental differences in the phosphorylation of I kappa B alpha induced by the two different NF-kappa B inducers. However, induction of I kappa B alpha phosphorylation by both TNF-alpha and the phosphatase inhibitors is associated with the subsequent degradation of I kappa B alpha. We further demonstrate that TNF-alpha- and calyculin A-induced I kappa B alpha degradation exhibits similar but not identical sensitivities to a proteasome inhibitor. Together, these results suggest that phosphorylation of I kappa B alpha, mediated through both the TNF-alpha-inducible and the PP-2A-opposing kinases, may serve to target I kappa B alpha for proteasome-mediated degradation.
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[ "Protein" ]
gelatinase granules is a cell_component, human neutrophils is a cell_type
11941_task0
Sentence: Isolation and characterization of gelatinase granules from human neutrophils. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: cell_type, cell_component
[ "O", "O", "O", "O", "B-cell_component", "I-cell_component", "O", "B-cell_type", "I-cell_type", "O" ]
Isolation and characterization of gelatinase granules from human neutrophils.
[ "Isolation", "and", "characterization", "of", "gelatinase", "granules", "from", "human", "neutrophils", "." ]
[ "other_name", "protein_molecule", "cell_component", "cell_type", "protein_family_or_group", "carbohydrate" ]
gelatinase granules is a cell_component, human neutrophils is a cell_type
11941_task1
Sentence: Isolation and characterization of gelatinase granules from human neutrophils. Instructions: please typing these entity words according to sentence: gelatinase granules, human neutrophils Options: cell_type, cell_component
[ "O", "O", "O", "O", "B-cell_component", "I-cell_component", "O", "B-cell_type", "I-cell_type", "O" ]
Isolation and characterization of gelatinase granules from human neutrophils.
[ "Isolation", "and", "characterization", "of", "gelatinase", "granules", "from", "human", "neutrophils", "." ]
[ "other_name", "protein_molecule", "cell_component", "cell_type", "protein_family_or_group", "carbohydrate" ]
gelatinase granules, human neutrophils
11941_task2
Sentence: Isolation and characterization of gelatinase granules from human neutrophils. Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "O", "B-cell_component", "I-cell_component", "O", "B-cell_type", "I-cell_type", "O" ]
Isolation and characterization of gelatinase granules from human neutrophils.
[ "Isolation", "and", "characterization", "of", "gelatinase", "granules", "from", "human", "neutrophils", "." ]
[ "other_name", "protein_molecule", "cell_component", "cell_type", "protein_family_or_group", "carbohydrate" ]
Schizophrenien is an umlsterm, Erwachsenenalters is an umlsterm, Schizophrenien is an umlsterm, Patienten is an umlsterm, Erkrankungsalter is an umlsterm, Syndrome is an umlsterm, Hauptkomponentenanalyse is an umlsterm, Geschlecht is an umlsterm, Faktorenanalyse is an umlsterm, Kognition - Affekt is an umlsterm, Verhalten is an umlsterm, Erregung is an umlsterm, Verhalten is an umlsterm, Erregung is an umlsterm, Erwachsenenbereich is an umlsterm, Schizophrenien is an umlsterm
DerNervenarzt.80690238.ger.abstr_task0
Sentence: Ausgehend von faktorenanalytischen Untersuchungen der Schizophrenien des Erwachsenenalters wird ein Modell zur Beschreibung der Symptomatik kindlicher Schizophrenien entwickelt . Anhand der Aktenauswertung von 44 schizophrenen Patienten ( Erkrankungsalter =14 Jahre ) erfolgt eine retrospektive Einschaetzung der Symptomatik der ersten Krankheitsepisode ( Positive and Negative Syndrome Scale , PANSS ; 15 ) . Ueber die 30 PANSS-Symptome wird eine Hauptkomponentenanalyse durchgefuehrt . Die Ergebnisse werden mit dem Remissionsgrad ( Disability Assessment Schedule , DAS-M ; 13 ) viele Jahre nach Erkrankungsbeginn in Beziehung gesetzt und auf Gruppenunterschiede hinsichtlich Geschlecht und Typ des Erkrankungsbeginns ( akut vs schleichend ) ueberprueft . Die Faktorenanalyse ergibt 5 unabhaengige Dimensionen , die 44% der Gesamtvarianz erklaeren : Kognition-Affekt sozialer Rueckzug , antisoziales Verhalten , Erregung und Realitaetsbezug . , Tendenziell weisen die Faktoren sozialer Rueckzug und Ralitaetsbezug einen Zusammenhang mit dem Remissionsgrad auf ( p 0.10 ) . Signifikante Gruppenunterschiede ergeben sich hinsichtlich der Faktoren antisoziales Verhalten und Erregung ( p 0.05 ) . Demnach sind wie , im Erwachsenenbereich , auch bei kindlichen Schizophrenien mehr als zwei Dimensionen fuer die Beschreibung der psychopathologischen Symptomatik notwendig . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
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Ausgehend von faktorenanalytischen Untersuchungen der Schizophrenien des Erwachsenenalters wird ein Modell zur Beschreibung der Symptomatik kindlicher Schizophrenien entwickelt . Anhand der Aktenauswertung von 44 schizophrenen Patienten ( Erkrankungsalter =14 Jahre ) erfolgt eine retrospektive Einschaetzung der Symptomatik der ersten Krankheitsepisode ( Positive and Negative Syndrome Scale , PANSS ; 15 ) . Ueber die 30 PANSS-Symptome wird eine Hauptkomponentenanalyse durchgefuehrt . Die Ergebnisse werden mit dem Remissionsgrad ( Disability Assessment Schedule , DAS-M ; 13 ) viele Jahre nach Erkrankungsbeginn in Beziehung gesetzt und auf Gruppenunterschiede hinsichtlich Geschlecht und Typ des Erkrankungsbeginns ( akut vs schleichend ) ueberprueft . Die Faktorenanalyse ergibt 5 unabhaengige Dimensionen , die 44% der Gesamtvarianz erklaeren : Kognition-Affekt sozialer Rueckzug , antisoziales Verhalten , Erregung und Realitaetsbezug . , Tendenziell weisen die Faktoren sozialer Rueckzug und Ralitaetsbezug einen Zusammenhang mit dem Remissionsgrad auf ( p 0.10 ) . Signifikante Gruppenunterschiede ergeben sich hinsichtlich der Faktoren antisoziales Verhalten und Erregung ( p 0.05 ) . Demnach sind wie , im Erwachsenenbereich , auch bei kindlichen Schizophrenien mehr als zwei Dimensionen fuer die Beschreibung der psychopathologischen Symptomatik notwendig .
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[ "umlsterm" ]
Schizophrenien is an umlsterm, Erwachsenenalters is an umlsterm, Schizophrenien is an umlsterm, Patienten is an umlsterm, Erkrankungsalter is an umlsterm, Syndrome is an umlsterm, Hauptkomponentenanalyse is an umlsterm, Geschlecht is an umlsterm, Faktorenanalyse is an umlsterm, Kognition - Affekt is an umlsterm, Verhalten is an umlsterm, Erregung is an umlsterm, Verhalten is an umlsterm, Erregung is an umlsterm, Erwachsenenbereich is an umlsterm, Schizophrenien is an umlsterm
DerNervenarzt.80690238.ger.abstr_task1
Sentence: Ausgehend von faktorenanalytischen Untersuchungen der Schizophrenien des Erwachsenenalters wird ein Modell zur Beschreibung der Symptomatik kindlicher Schizophrenien entwickelt . Anhand der Aktenauswertung von 44 schizophrenen Patienten ( Erkrankungsalter =14 Jahre ) erfolgt eine retrospektive Einschaetzung der Symptomatik der ersten Krankheitsepisode ( Positive and Negative Syndrome Scale , PANSS ; 15 ) . Ueber die 30 PANSS-Symptome wird eine Hauptkomponentenanalyse durchgefuehrt . Die Ergebnisse werden mit dem Remissionsgrad ( Disability Assessment Schedule , DAS-M ; 13 ) viele Jahre nach Erkrankungsbeginn in Beziehung gesetzt und auf Gruppenunterschiede hinsichtlich Geschlecht und Typ des Erkrankungsbeginns ( akut vs schleichend ) ueberprueft . Die Faktorenanalyse ergibt 5 unabhaengige Dimensionen , die 44% der Gesamtvarianz erklaeren : Kognition-Affekt sozialer Rueckzug , antisoziales Verhalten , Erregung und Realitaetsbezug . , Tendenziell weisen die Faktoren sozialer Rueckzug und Ralitaetsbezug einen Zusammenhang mit dem Remissionsgrad auf ( p 0.10 ) . Signifikante Gruppenunterschiede ergeben sich hinsichtlich der Faktoren antisoziales Verhalten und Erregung ( p 0.05 ) . Demnach sind wie , im Erwachsenenbereich , auch bei kindlichen Schizophrenien mehr als zwei Dimensionen fuer die Beschreibung der psychopathologischen Symptomatik notwendig . Instructions: please typing these entity words according to sentence: Schizophrenien, Erwachsenenalters, Schizophrenien, Patienten, Erkrankungsalter, Syndrome, Hauptkomponentenanalyse, Geschlecht, Faktorenanalyse, Kognition - Affekt, Verhalten, Erregung, Verhalten, Erregung, Erwachsenenbereich, Schizophrenien Options: umlsterm
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Ausgehend von faktorenanalytischen Untersuchungen der Schizophrenien des Erwachsenenalters wird ein Modell zur Beschreibung der Symptomatik kindlicher Schizophrenien entwickelt . Anhand der Aktenauswertung von 44 schizophrenen Patienten ( Erkrankungsalter =14 Jahre ) erfolgt eine retrospektive Einschaetzung der Symptomatik der ersten Krankheitsepisode ( Positive and Negative Syndrome Scale , PANSS ; 15 ) . Ueber die 30 PANSS-Symptome wird eine Hauptkomponentenanalyse durchgefuehrt . Die Ergebnisse werden mit dem Remissionsgrad ( Disability Assessment Schedule , DAS-M ; 13 ) viele Jahre nach Erkrankungsbeginn in Beziehung gesetzt und auf Gruppenunterschiede hinsichtlich Geschlecht und Typ des Erkrankungsbeginns ( akut vs schleichend ) ueberprueft . Die Faktorenanalyse ergibt 5 unabhaengige Dimensionen , die 44% der Gesamtvarianz erklaeren : Kognition-Affekt sozialer Rueckzug , antisoziales Verhalten , Erregung und Realitaetsbezug . , Tendenziell weisen die Faktoren sozialer Rueckzug und Ralitaetsbezug einen Zusammenhang mit dem Remissionsgrad auf ( p 0.10 ) . Signifikante Gruppenunterschiede ergeben sich hinsichtlich der Faktoren antisoziales Verhalten und Erregung ( p 0.05 ) . Demnach sind wie , im Erwachsenenbereich , auch bei kindlichen Schizophrenien mehr als zwei Dimensionen fuer die Beschreibung der psychopathologischen Symptomatik notwendig .
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[ "umlsterm" ]
Schizophrenien, Erwachsenenalters, Schizophrenien, Patienten, Erkrankungsalter, Syndrome, Hauptkomponentenanalyse, Geschlecht, Faktorenanalyse, Kognition - Affekt, Verhalten, Erregung, Verhalten, Erregung, Erwachsenenbereich, Schizophrenien
DerNervenarzt.80690238.ger.abstr_task2
Sentence: Ausgehend von faktorenanalytischen Untersuchungen der Schizophrenien des Erwachsenenalters wird ein Modell zur Beschreibung der Symptomatik kindlicher Schizophrenien entwickelt . Anhand der Aktenauswertung von 44 schizophrenen Patienten ( Erkrankungsalter =14 Jahre ) erfolgt eine retrospektive Einschaetzung der Symptomatik der ersten Krankheitsepisode ( Positive and Negative Syndrome Scale , PANSS ; 15 ) . Ueber die 30 PANSS-Symptome wird eine Hauptkomponentenanalyse durchgefuehrt . Die Ergebnisse werden mit dem Remissionsgrad ( Disability Assessment Schedule , DAS-M ; 13 ) viele Jahre nach Erkrankungsbeginn in Beziehung gesetzt und auf Gruppenunterschiede hinsichtlich Geschlecht und Typ des Erkrankungsbeginns ( akut vs schleichend ) ueberprueft . Die Faktorenanalyse ergibt 5 unabhaengige Dimensionen , die 44% der Gesamtvarianz erklaeren : Kognition-Affekt sozialer Rueckzug , antisoziales Verhalten , Erregung und Realitaetsbezug . , Tendenziell weisen die Faktoren sozialer Rueckzug und Ralitaetsbezug einen Zusammenhang mit dem Remissionsgrad auf ( p 0.10 ) . Signifikante Gruppenunterschiede ergeben sich hinsichtlich der Faktoren antisoziales Verhalten und Erregung ( p 0.05 ) . Demnach sind wie , im Erwachsenenbereich , auch bei kindlichen Schizophrenien mehr als zwei Dimensionen fuer die Beschreibung der psychopathologischen Symptomatik notwendig . Instructions: please extract entity words from the input sentence
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Ausgehend von faktorenanalytischen Untersuchungen der Schizophrenien des Erwachsenenalters wird ein Modell zur Beschreibung der Symptomatik kindlicher Schizophrenien entwickelt . Anhand der Aktenauswertung von 44 schizophrenen Patienten ( Erkrankungsalter =14 Jahre ) erfolgt eine retrospektive Einschaetzung der Symptomatik der ersten Krankheitsepisode ( Positive and Negative Syndrome Scale , PANSS ; 15 ) . Ueber die 30 PANSS-Symptome wird eine Hauptkomponentenanalyse durchgefuehrt . Die Ergebnisse werden mit dem Remissionsgrad ( Disability Assessment Schedule , DAS-M ; 13 ) viele Jahre nach Erkrankungsbeginn in Beziehung gesetzt und auf Gruppenunterschiede hinsichtlich Geschlecht und Typ des Erkrankungsbeginns ( akut vs schleichend ) ueberprueft . Die Faktorenanalyse ergibt 5 unabhaengige Dimensionen , die 44% der Gesamtvarianz erklaeren : Kognition-Affekt sozialer Rueckzug , antisoziales Verhalten , Erregung und Realitaetsbezug . , Tendenziell weisen die Faktoren sozialer Rueckzug und Ralitaetsbezug einen Zusammenhang mit dem Remissionsgrad auf ( p 0.10 ) . Signifikante Gruppenunterschiede ergeben sich hinsichtlich der Faktoren antisoziales Verhalten und Erregung ( p 0.05 ) . Demnach sind wie , im Erwachsenenbereich , auch bei kindlichen Schizophrenien mehr als zwei Dimensionen fuer die Beschreibung der psychopathologischen Symptomatik notwendig .
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[ "umlsterm" ]
Opioide is an umlsterm, Vorurteile is an umlsterm, Aerzte is an umlsterm, Apotheker is an umlsterm, Apotheker is an umlsterm, Langzeittherapie is an umlsterm, Fragebogen is an umlsterm
DerSchmerz.90130043.ger.abstr_task0
Sentence: Die Verschreibung der stark wirksamen Opioide unterliegt der BtMVV . Vorurteile gegenueber dieser Verordnung sind fuer Aerzte immer wieder beschrieben worden . Ein Glied in der Versorgungskette stellen insbesondere die Apotheker dar , die bisher zu ihrer Einstellung nie befragt wurden . Die Einstellung der Apotheker zur Langzeittherapie mit BtM-Analgetika und ihre Einstellung zur BtMVV wurde mittels Fragebogen untersucht . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]
Die Verschreibung der stark wirksamen Opioide unterliegt der BtMVV . Vorurteile gegenueber dieser Verordnung sind fuer Aerzte immer wieder beschrieben worden . Ein Glied in der Versorgungskette stellen insbesondere die Apotheker dar , die bisher zu ihrer Einstellung nie befragt wurden . Die Einstellung der Apotheker zur Langzeittherapie mit BtM-Analgetika und ihre Einstellung zur BtMVV wurde mittels Fragebogen untersucht .
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[ "umlsterm" ]
Opioide is an umlsterm, Vorurteile is an umlsterm, Aerzte is an umlsterm, Apotheker is an umlsterm, Apotheker is an umlsterm, Langzeittherapie is an umlsterm, Fragebogen is an umlsterm
DerSchmerz.90130043.ger.abstr_task1
Sentence: Die Verschreibung der stark wirksamen Opioide unterliegt der BtMVV . Vorurteile gegenueber dieser Verordnung sind fuer Aerzte immer wieder beschrieben worden . Ein Glied in der Versorgungskette stellen insbesondere die Apotheker dar , die bisher zu ihrer Einstellung nie befragt wurden . Die Einstellung der Apotheker zur Langzeittherapie mit BtM-Analgetika und ihre Einstellung zur BtMVV wurde mittels Fragebogen untersucht . Instructions: please typing these entity words according to sentence: Opioide, Vorurteile, Aerzte, Apotheker, Apotheker, Langzeittherapie, Fragebogen Options: umlsterm
[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]
Die Verschreibung der stark wirksamen Opioide unterliegt der BtMVV . Vorurteile gegenueber dieser Verordnung sind fuer Aerzte immer wieder beschrieben worden . Ein Glied in der Versorgungskette stellen insbesondere die Apotheker dar , die bisher zu ihrer Einstellung nie befragt wurden . Die Einstellung der Apotheker zur Langzeittherapie mit BtM-Analgetika und ihre Einstellung zur BtMVV wurde mittels Fragebogen untersucht .
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[ "umlsterm" ]
Opioide, Vorurteile, Aerzte, Apotheker, Apotheker, Langzeittherapie, Fragebogen
DerSchmerz.90130043.ger.abstr_task2
Sentence: Die Verschreibung der stark wirksamen Opioide unterliegt der BtMVV . Vorurteile gegenueber dieser Verordnung sind fuer Aerzte immer wieder beschrieben worden . Ein Glied in der Versorgungskette stellen insbesondere die Apotheker dar , die bisher zu ihrer Einstellung nie befragt wurden . Die Einstellung der Apotheker zur Langzeittherapie mit BtM-Analgetika und ihre Einstellung zur BtMVV wurde mittels Fragebogen untersucht . Instructions: please extract entity words from the input sentence
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Die Verschreibung der stark wirksamen Opioide unterliegt der BtMVV . Vorurteile gegenueber dieser Verordnung sind fuer Aerzte immer wieder beschrieben worden . Ein Glied in der Versorgungskette stellen insbesondere die Apotheker dar , die bisher zu ihrer Einstellung nie befragt wurden . Die Einstellung der Apotheker zur Langzeittherapie mit BtM-Analgetika und ihre Einstellung zur BtMVV wurde mittels Fragebogen untersucht .
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[ "umlsterm" ]
profession is an umlsterm, geriatric nurse is an umlsterm, care is an umlsterm, development is an umlsterm, profession is an umlsterm, geriatric nurse is an umlsterm, legislation is an umlsterm, law is an umlsterm, developments is an umlsterm, profession is an umlsterm, geriatric nurse is an umlsterm, vision is an umlsterm
ZfuerGerontologie+Geriatrie.90320024.eng.abstr_task0
Sentence: Historically , the profession of geriatric nurse has arisen from the care of the sick and has developed very differently from region to region . A question as to the status of development of the profession of geriatric nurse cannot be answered by reference to the current status of legislation on professional law matters . If experts in that field focus too long on such matters , there is a danger that decisive developments in the profession of geriatric nurse take place outside their field of vision . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm
[ "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]
Historically , the profession of geriatric nurse has arisen from the care of the sick and has developed very differently from region to region . A question as to the status of development of the profession of geriatric nurse cannot be answered by reference to the current status of legislation on professional law matters . If experts in that field focus too long on such matters , there is a danger that decisive developments in the profession of geriatric nurse take place outside their field of vision .
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[ "umlsterm" ]
profession is an umlsterm, geriatric nurse is an umlsterm, care is an umlsterm, development is an umlsterm, profession is an umlsterm, geriatric nurse is an umlsterm, legislation is an umlsterm, law is an umlsterm, developments is an umlsterm, profession is an umlsterm, geriatric nurse is an umlsterm, vision is an umlsterm
ZfuerGerontologie+Geriatrie.90320024.eng.abstr_task1
Sentence: Historically , the profession of geriatric nurse has arisen from the care of the sick and has developed very differently from region to region . A question as to the status of development of the profession of geriatric nurse cannot be answered by reference to the current status of legislation on professional law matters . If experts in that field focus too long on such matters , there is a danger that decisive developments in the profession of geriatric nurse take place outside their field of vision . Instructions: please typing these entity words according to sentence: profession, geriatric nurse, care, development, profession, geriatric nurse, legislation, law, developments, profession, geriatric nurse, vision Options: umlsterm
[ "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]
Historically , the profession of geriatric nurse has arisen from the care of the sick and has developed very differently from region to region . A question as to the status of development of the profession of geriatric nurse cannot be answered by reference to the current status of legislation on professional law matters . If experts in that field focus too long on such matters , there is a danger that decisive developments in the profession of geriatric nurse take place outside their field of vision .
[ "Historically", ",", "the", "profession", "of", "geriatric", "nurse", "has", "arisen", "from", "the", "care", "of", "the", "sick", "and", "has", "developed", "very", "differently", "from", "region", "to", "region", ".", "A", "question", "as", "to", "the", "status", "of", "development", "of", "the", "profession", "of", "geriatric", "nurse", "cannot", "be", "answered", "by", "reference", "to", "the", "current", "status", "of", "legislation", "on", "professional", "law", "matters", ".", "If", "experts", "in", "that", "field", "focus", "too", "long", "on", "such", "matters", ",", "there", "is", "a", "danger", "that", "decisive", "developments", "in", "the", "profession", "of", "geriatric", "nurse", "take", "place", "outside", "their", "field", "of", "vision", "." ]
[ "umlsterm" ]
profession, geriatric nurse, care, development, profession, geriatric nurse, legislation, law, developments, profession, geriatric nurse, vision
ZfuerGerontologie+Geriatrie.90320024.eng.abstr_task2
Sentence: Historically , the profession of geriatric nurse has arisen from the care of the sick and has developed very differently from region to region . A question as to the status of development of the profession of geriatric nurse cannot be answered by reference to the current status of legislation on professional law matters . If experts in that field focus too long on such matters , there is a danger that decisive developments in the profession of geriatric nurse take place outside their field of vision . Instructions: please extract entity words from the input sentence
[ "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]
Historically , the profession of geriatric nurse has arisen from the care of the sick and has developed very differently from region to region . A question as to the status of development of the profession of geriatric nurse cannot be answered by reference to the current status of legislation on professional law matters . If experts in that field focus too long on such matters , there is a danger that decisive developments in the profession of geriatric nurse take place outside their field of vision .
[ "Historically", ",", "the", "profession", "of", "geriatric", "nurse", "has", "arisen", "from", "the", "care", "of", "the", "sick", "and", "has", "developed", "very", "differently", "from", "region", "to", "region", ".", "A", "question", "as", "to", "the", "status", "of", "development", "of", "the", "profession", "of", "geriatric", "nurse", "cannot", "be", "answered", "by", "reference", "to", "the", "current", "status", "of", "legislation", "on", "professional", "law", "matters", ".", "If", "experts", "in", "that", "field", "focus", "too", "long", "on", "such", "matters", ",", "there", "is", "a", "danger", "that", "decisive", "developments", "in", "the", "profession", "of", "geriatric", "nurse", "take", "place", "outside", "their", "field", "of", "vision", "." ]
[ "umlsterm" ]