bio-datasets/bigbio-ner-merged · Datasets at Hugging Face

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thrombocytopenic subjects with hepatitis C virus infection is a Participant_Condition, n = 1463 is a Participant_Sample-size, age ≥ 18 years is a Participant_Age, HCV infection is a Participant_Condition, include : having a HCV genotype 2 or 3 , being Central / South Asian , being White ( Caucasian or European heritage ) , increased weight , and increased spleen length is a Outcome_Physical, include : female gender , increased age , having a higher ALP plasma concentration , increased creatinine clearance , increased baseline lymphocytes count , and increased baseline platelet count is a Outcome_Physical	72138_task1	Sentence: Eltrombopag dose predictors in thrombocytopenic subjects with hepatitis C virus infection . This study aims to identify patient characteristics that predict effective eltrombopag dosage for the treatment of Hepatitis C virus ( HCV ) -related thrombocytopenia . Demographic , clinical and genetic data collected from thrombocytopenic patients ( n = 1463 , age ≥ 18 years ) with chronic HCV infection who were able to achieve a target platelet count of > 90 × 10 ( 9 ) /L following eltrombopag treatment . Patients were categorized into four groups ( 25 , 50 , 75 , and 100 mg ) based on the eltrombopag dose needed to achieve the target platelet count . Eltrombopag dose predictors were identified using a two stage approach . First , bivariate analysis , using anova for continuous variables and Chi-square test for categorical variables , was performed to identify possible predictors of eltrombopag dose ( P < 0.05 ) . Second , ordinal logistic regression with stepwise addition followed by backward deletion was then performed using predictors identified in bivariate analysis step to produce final model containing independent predictors at P < 0.05 . Ordinal logistic model identified several predictors of eltrombopag dose . Predictors of higher eltrombopag dose include : having a HCV genotype 2 or 3 , being Central/South Asian , being White ( Caucasian or European heritage ) , increased weight , and increased spleen length . Predictors of lower eltrombopag dose include : female gender , increased age , having a higher ALP plasma concentration , increased creatinine clearance , increased baseline lymphocytes count , and increased baseline platelet count . In conclusion , this study identified patient characteristics that predict effective eltrombopag dose for the treatment of HCV-related thrombocytopenia . Early selection of the optimal eltrombopag dose expedites the initiation of antiviral therapy . This is expected to improve the antiviral therapy outcome before the patient progress into liver decompensation . Instructions: please typing these entity words according to sentence: thrombocytopenic subjects with hepatitis C virus infection, n = 1463, age ≥ 18 years, HCV infection, include : having a HCV genotype 2 or 3 , being Central / South Asian , being White ( Caucasian or European heritage ) , increased weight , and increased spleen length, include : female gender , increased age , having a higher ALP plasma concentration , increased creatinine clearance , increased baseline lymphocytes count , and increased baseline platelet count Options: Outcome_Physical, Participant_Age, Participant_Condition, Participant_Sample-size	[ "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Eltrombopag dose predictors in thrombocytopenic subjects with hepatitis C virus infection . This study aims to identify patient characteristics that predict effective eltrombopag dosage for the treatment of Hepatitis C virus ( HCV ) -related thrombocytopenia . Demographic , clinical and genetic data collected from thrombocytopenic patients ( n = 1463 , age ≥ 18 years ) with chronic HCV infection who were able to achieve a target platelet count of > 90 × 10 ( 9 ) /L following eltrombopag treatment . Patients were categorized into four groups ( 25 , 50 , 75 , and 100 mg ) based on the eltrombopag dose needed to achieve the target platelet count . Eltrombopag dose predictors were identified using a two stage approach . First , bivariate analysis , using anova for continuous variables and Chi-square test for categorical variables , was performed to identify possible predictors of eltrombopag dose ( P < 0.05 ) . Second , ordinal logistic regression with stepwise addition followed by backward deletion was then performed using predictors identified in bivariate analysis step to produce final model containing independent predictors at P < 0.05 . Ordinal logistic model identified several predictors of eltrombopag dose . Predictors of higher eltrombopag dose include : having a HCV genotype 2 or 3 , being Central/South Asian , being White ( Caucasian or European heritage ) , increased weight , and increased spleen length . Predictors of lower eltrombopag dose include : female gender , increased age , having a higher ALP plasma concentration , increased creatinine clearance , increased baseline lymphocytes count , and increased baseline platelet count . In conclusion , this study identified patient characteristics that predict effective eltrombopag dose for the treatment of HCV-related thrombocytopenia . Early selection of the optimal eltrombopag dose expedites the initiation of antiviral therapy . This is expected to improve the antiviral therapy outcome before the patient progress into liver decompensation .	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thrombocytopenic subjects with hepatitis C virus infection, n = 1463, age ≥ 18 years, HCV infection, include : having a HCV genotype 2 or 3 , being Central / South Asian , being White ( Caucasian or European heritage ) , increased weight , and increased spleen length, include : female gender , increased age , having a higher ALP plasma concentration , increased creatinine clearance , increased baseline lymphocytes count , and increased baseline platelet count	72138_task2	Sentence: Eltrombopag dose predictors in thrombocytopenic subjects with hepatitis C virus infection . This study aims to identify patient characteristics that predict effective eltrombopag dosage for the treatment of Hepatitis C virus ( HCV ) -related thrombocytopenia . Demographic , clinical and genetic data collected from thrombocytopenic patients ( n = 1463 , age ≥ 18 years ) with chronic HCV infection who were able to achieve a target platelet count of > 90 × 10 ( 9 ) /L following eltrombopag treatment . Patients were categorized into four groups ( 25 , 50 , 75 , and 100 mg ) based on the eltrombopag dose needed to achieve the target platelet count . Eltrombopag dose predictors were identified using a two stage approach . First , bivariate analysis , using anova for continuous variables and Chi-square test for categorical variables , was performed to identify possible predictors of eltrombopag dose ( P < 0.05 ) . Second , ordinal logistic regression with stepwise addition followed by backward deletion was then performed using predictors identified in bivariate analysis step to produce final model containing independent predictors at P < 0.05 . Ordinal logistic model identified several predictors of eltrombopag dose . Predictors of higher eltrombopag dose include : having a HCV genotype 2 or 3 , being Central/South Asian , being White ( Caucasian or European heritage ) , increased weight , and increased spleen length . Predictors of lower eltrombopag dose include : female gender , increased age , having a higher ALP plasma concentration , increased creatinine clearance , increased baseline lymphocytes count , and increased baseline platelet count . In conclusion , this study identified patient characteristics that predict effective eltrombopag dose for the treatment of HCV-related thrombocytopenia . Early selection of the optimal eltrombopag dose expedites the initiation of antiviral therapy . This is expected to improve the antiviral therapy outcome before the patient progress into liver decompensation . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Eltrombopag dose predictors in thrombocytopenic subjects with hepatitis C virus infection . This study aims to identify patient characteristics that predict effective eltrombopag dosage for the treatment of Hepatitis C virus ( HCV ) -related thrombocytopenia . Demographic , clinical and genetic data collected from thrombocytopenic patients ( n = 1463 , age ≥ 18 years ) with chronic HCV infection who were able to achieve a target platelet count of > 90 × 10 ( 9 ) /L following eltrombopag treatment . Patients were categorized into four groups ( 25 , 50 , 75 , and 100 mg ) based on the eltrombopag dose needed to achieve the target platelet count . Eltrombopag dose predictors were identified using a two stage approach . First , bivariate analysis , using anova for continuous variables and Chi-square test for categorical variables , was performed to identify possible predictors of eltrombopag dose ( P < 0.05 ) . Second , ordinal logistic regression with stepwise addition followed by backward deletion was then performed using predictors identified in bivariate analysis step to produce final model containing independent predictors at P < 0.05 . Ordinal logistic model identified several predictors of eltrombopag dose . Predictors of higher eltrombopag dose include : having a HCV genotype 2 or 3 , being Central/South Asian , being White ( Caucasian or European heritage ) , increased weight , and increased spleen length . Predictors of lower eltrombopag dose include : female gender , increased age , having a higher ALP plasma concentration , increased creatinine clearance , increased baseline lymphocytes count , and increased baseline platelet count . In conclusion , this study identified patient characteristics that predict effective eltrombopag dose for the treatment of HCV-related thrombocytopenia . Early selection of the optimal eltrombopag dose expedites the initiation of antiviral therapy . This is expected to improve the antiviral therapy outcome before the patient progress into liver decompensation .	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younger than 18 years is a Value, old is a Person, HBsAg negative is a Condition, at baseline is a Temporal, pregnant or lactating is a Scope, women is a Person	NCT01768195_exc_task0	Sentence: younger than 18 years old HBsAg negative at baseline pregnant or lactating women Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Temporal, Condition, Value, Person, Scope	[ "B-Value", "I-Value", "I-Value", "I-Value", "B-Person", "O", "B-Condition", "I-Condition", "B-Temporal", "I-Temporal", "O", "B-Scope", "I-Scope", "I-Scope", "B-Person", "O" ]	younger than 18 years old HBsAg negative at baseline pregnant or lactating women	[ "younger", "than", "18", "years", "old", "\n", "HBsAg", "negative", "at", "baseline", "\n", "pregnant", "or", "lactating", "women", "\n" ]	[ "Value", "Scope", "Condition", "Temporal", "Person" ]
younger than 18 years is a Value, old is a Person, HBsAg negative is a Condition, at baseline is a Temporal, pregnant or lactating is a Scope, women is a Person	NCT01768195_exc_task1	Sentence: younger than 18 years old HBsAg negative at baseline pregnant or lactating women Instructions: please typing these entity words according to sentence: younger than 18 years, old, HBsAg negative, at baseline, pregnant or lactating, women Options: Temporal, Condition, Value, Person, Scope	[ "B-Value", "I-Value", "I-Value", "I-Value", "B-Person", "O", "B-Condition", "I-Condition", "B-Temporal", "I-Temporal", "O", "B-Scope", "I-Scope", "I-Scope", "B-Person", "O" ]	younger than 18 years old HBsAg negative at baseline pregnant or lactating women	[ "younger", "than", "18", "years", "old", "\n", "HBsAg", "negative", "at", "baseline", "\n", "pregnant", "or", "lactating", "women", "\n" ]	[ "Value", "Scope", "Condition", "Temporal", "Person" ]
younger than 18 years, old, HBsAg negative, at baseline, pregnant or lactating, women	NCT01768195_exc_task2	Sentence: younger than 18 years old HBsAg negative at baseline pregnant or lactating women Instructions: please extract entity words from the input sentence	[ "B-Value", "I-Value", "I-Value", "I-Value", "B-Person", "O", "B-Condition", "I-Condition", "B-Temporal", "I-Temporal", "O", "B-Scope", "I-Scope", "I-Scope", "B-Person", "O" ]	younger than 18 years old HBsAg negative at baseline pregnant or lactating women	[ "younger", "than", "18", "years", "old", "\n", "HBsAg", "negative", "at", "baseline", "\n", "pregnant", "or", "lactating", "women", "\n" ]	[ "Value", "Scope", "Condition", "Temporal", "Person" ]
Behandlung is an umlsterm, Personen is an umlsterm, Behandlung is an umlsterm, selbst is an umlsterm, Wissen is an umlsterm	DerUnfallchirurg.81010402.ger.abstr_task0	Sentence: Bei der Behandlung von Personen mit Schussverletzungen sollten kriminalistische Gesichtspunkte nicht ganz ausser acht bleiben , denn fuer die Ermittlungsbehoerden ergibt sich die Notwendigkeit zu klaeren , wer geschossen hat , aus welcher Richtung und Entfernung geschossen wurde und wie viele Schuesse es waren . Hierzu koennen Feststellungen des behandelnden Chirurgen entscheidend weiterhelfen . Sie setzen vor allem eine sorgfaeltige Inspektion voraus . Fuer die Behandlung selbst ist das Wissen darum wichtig , dass Schusskanaele nicht immer geradlinig durch den Koerper verlaufen . Liegt ein Winkelschuss , ein gebrochener Schusskanal oder ein Kontur- oder Ringelschuss vor , koennen Organe verletzt werden , die nicht auf der direkten Verbindungslinie zwischen dem Einschuss und dem Ausschuss bzw. - bei einem Steckschuss - dem Einschuss und der Endlage des Projektils liegen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Bei der Behandlung von Personen mit Schussverletzungen sollten kriminalistische Gesichtspunkte nicht ganz ausser acht bleiben , denn fuer die Ermittlungsbehoerden ergibt sich die Notwendigkeit zu klaeren , wer geschossen hat , aus welcher Richtung und Entfernung geschossen wurde und wie viele Schuesse es waren . Hierzu koennen Feststellungen des behandelnden Chirurgen entscheidend weiterhelfen . Sie setzen vor allem eine sorgfaeltige Inspektion voraus . Fuer die Behandlung selbst ist das Wissen darum wichtig , dass Schusskanaele nicht immer geradlinig durch den Koerper verlaufen . Liegt ein Winkelschuss , ein gebrochener Schusskanal oder ein Kontur- oder Ringelschuss vor , koennen Organe verletzt werden , die nicht auf der direkten Verbindungslinie zwischen dem Einschuss und dem Ausschuss bzw. - bei einem Steckschuss - dem Einschuss und der Endlage des Projektils liegen .	[ "Bei", "der", "Behandlung", "von", "Personen", "mit", "Schussverletzungen", "sollten", "kriminalistische", "Gesichtspunkte", "nicht", "ganz", "ausser", "acht", "bleiben", ",", "denn", "fuer", "die", "Ermittlungsbehoerden", "ergibt", "sich", "die", "Notwendigkeit", "zu", "klaeren", ",", "wer", "geschossen", "hat", ",", "aus", "welcher", "Richtung", "und", "Entfernung", "geschossen", "wurde", "und", "wie", "viele", "Schuesse", "es", "waren", ".", "Hierzu", "koennen", "Feststellungen", "des", "behandelnden", "Chirurgen", "entscheidend", "weiterhelfen", ".", "Sie", "setzen", "vor", "allem", "eine", "sorgfaeltige", "Inspektion", "voraus", ".", "Fuer", "die", "Behandlung", "selbst", "ist", "das", "Wissen", "darum", "wichtig", ",", "dass", "Schusskanaele", "nicht", "immer", "geradlinig", "durch", "den", "Koerper", "verlaufen", ".", "Liegt", "ein", "Winkelschuss", ",", "ein", "gebrochener", "Schusskanal", "oder", "ein", "Kontur-", "oder", "Ringelschuss", "vor", ",", "koennen", "Organe", "verletzt", "werden", ",", "die", "nicht", "auf", "der", "direkten", "Verbindungslinie", "zwischen", "dem", "Einschuss", "und", "dem", "Ausschuss", "bzw", ".", "-", "bei", "einem", "Steckschuss", "-", "dem", "Einschuss", "und", "der", "Endlage", "des", "Projektils", "liegen", "." ]	[ "umlsterm" ]
Behandlung is an umlsterm, Personen is an umlsterm, Behandlung is an umlsterm, selbst is an umlsterm, Wissen is an umlsterm	DerUnfallchirurg.81010402.ger.abstr_task1	Sentence: Bei der Behandlung von Personen mit Schussverletzungen sollten kriminalistische Gesichtspunkte nicht ganz ausser acht bleiben , denn fuer die Ermittlungsbehoerden ergibt sich die Notwendigkeit zu klaeren , wer geschossen hat , aus welcher Richtung und Entfernung geschossen wurde und wie viele Schuesse es waren . Hierzu koennen Feststellungen des behandelnden Chirurgen entscheidend weiterhelfen . Sie setzen vor allem eine sorgfaeltige Inspektion voraus . Fuer die Behandlung selbst ist das Wissen darum wichtig , dass Schusskanaele nicht immer geradlinig durch den Koerper verlaufen . Liegt ein Winkelschuss , ein gebrochener Schusskanal oder ein Kontur- oder Ringelschuss vor , koennen Organe verletzt werden , die nicht auf der direkten Verbindungslinie zwischen dem Einschuss und dem Ausschuss bzw. - bei einem Steckschuss - dem Einschuss und der Endlage des Projektils liegen . Instructions: please typing these entity words according to sentence: Behandlung, Personen, Behandlung, selbst, Wissen Options: umlsterm	[ "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Bei der Behandlung von Personen mit Schussverletzungen sollten kriminalistische Gesichtspunkte nicht ganz ausser acht bleiben , denn fuer die Ermittlungsbehoerden ergibt sich die Notwendigkeit zu klaeren , wer geschossen hat , aus welcher Richtung und Entfernung geschossen wurde und wie viele Schuesse es waren . Hierzu koennen Feststellungen des behandelnden Chirurgen entscheidend weiterhelfen . Sie setzen vor allem eine sorgfaeltige Inspektion voraus . Fuer die Behandlung selbst ist das Wissen darum wichtig , dass Schusskanaele nicht immer geradlinig durch den Koerper verlaufen . Liegt ein Winkelschuss , ein gebrochener Schusskanal oder ein Kontur- oder Ringelschuss vor , koennen Organe verletzt werden , die nicht auf der direkten Verbindungslinie zwischen dem Einschuss und dem Ausschuss bzw. - bei einem Steckschuss - dem Einschuss und der Endlage des Projektils liegen .	[ "Bei", "der", "Behandlung", "von", "Personen", "mit", "Schussverletzungen", "sollten", "kriminalistische", "Gesichtspunkte", "nicht", "ganz", "ausser", "acht", "bleiben", ",", "denn", "fuer", "die", "Ermittlungsbehoerden", "ergibt", "sich", "die", "Notwendigkeit", "zu", "klaeren", ",", "wer", "geschossen", "hat", ",", "aus", "welcher", "Richtung", "und", "Entfernung", "geschossen", "wurde", "und", "wie", "viele", "Schuesse", "es", "waren", ".", "Hierzu", "koennen", "Feststellungen", "des", "behandelnden", "Chirurgen", "entscheidend", "weiterhelfen", ".", "Sie", "setzen", "vor", "allem", "eine", "sorgfaeltige", "Inspektion", "voraus", ".", "Fuer", "die", "Behandlung", "selbst", "ist", "das", "Wissen", "darum", "wichtig", ",", "dass", "Schusskanaele", "nicht", "immer", "geradlinig", "durch", "den", "Koerper", "verlaufen", ".", "Liegt", "ein", "Winkelschuss", ",", "ein", "gebrochener", "Schusskanal", "oder", "ein", "Kontur-", "oder", "Ringelschuss", "vor", ",", "koennen", "Organe", "verletzt", "werden", ",", "die", "nicht", "auf", "der", "direkten", "Verbindungslinie", "zwischen", "dem", "Einschuss", "und", "dem", "Ausschuss", "bzw", ".", "-", "bei", "einem", "Steckschuss", "-", "dem", "Einschuss", "und", "der", "Endlage", "des", "Projektils", "liegen", "." ]	[ "umlsterm" ]
Behandlung, Personen, Behandlung, selbst, Wissen	DerUnfallchirurg.81010402.ger.abstr_task2	Sentence: Bei der Behandlung von Personen mit Schussverletzungen sollten kriminalistische Gesichtspunkte nicht ganz ausser acht bleiben , denn fuer die Ermittlungsbehoerden ergibt sich die Notwendigkeit zu klaeren , wer geschossen hat , aus welcher Richtung und Entfernung geschossen wurde und wie viele Schuesse es waren . Hierzu koennen Feststellungen des behandelnden Chirurgen entscheidend weiterhelfen . Sie setzen vor allem eine sorgfaeltige Inspektion voraus . Fuer die Behandlung selbst ist das Wissen darum wichtig , dass Schusskanaele nicht immer geradlinig durch den Koerper verlaufen . Liegt ein Winkelschuss , ein gebrochener Schusskanal oder ein Kontur- oder Ringelschuss vor , koennen Organe verletzt werden , die nicht auf der direkten Verbindungslinie zwischen dem Einschuss und dem Ausschuss bzw. - bei einem Steckschuss - dem Einschuss und der Endlage des Projektils liegen . Instructions: please extract entity words from the input sentence	[ "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Bei der Behandlung von Personen mit Schussverletzungen sollten kriminalistische Gesichtspunkte nicht ganz ausser acht bleiben , denn fuer die Ermittlungsbehoerden ergibt sich die Notwendigkeit zu klaeren , wer geschossen hat , aus welcher Richtung und Entfernung geschossen wurde und wie viele Schuesse es waren . Hierzu koennen Feststellungen des behandelnden Chirurgen entscheidend weiterhelfen . Sie setzen vor allem eine sorgfaeltige Inspektion voraus . Fuer die Behandlung selbst ist das Wissen darum wichtig , dass Schusskanaele nicht immer geradlinig durch den Koerper verlaufen . Liegt ein Winkelschuss , ein gebrochener Schusskanal oder ein Kontur- oder Ringelschuss vor , koennen Organe verletzt werden , die nicht auf der direkten Verbindungslinie zwischen dem Einschuss und dem Ausschuss bzw. - bei einem Steckschuss - dem Einschuss und der Endlage des Projektils liegen .	[ "Bei", "der", "Behandlung", "von", "Personen", "mit", "Schussverletzungen", "sollten", "kriminalistische", "Gesichtspunkte", "nicht", "ganz", "ausser", "acht", "bleiben", ",", "denn", "fuer", "die", "Ermittlungsbehoerden", "ergibt", "sich", "die", "Notwendigkeit", "zu", "klaeren", ",", "wer", "geschossen", "hat", ",", "aus", "welcher", "Richtung", "und", "Entfernung", "geschossen", "wurde", "und", "wie", "viele", "Schuesse", "es", "waren", ".", "Hierzu", "koennen", "Feststellungen", "des", "behandelnden", "Chirurgen", "entscheidend", "weiterhelfen", ".", "Sie", "setzen", "vor", "allem", "eine", "sorgfaeltige", "Inspektion", "voraus", ".", "Fuer", "die", "Behandlung", "selbst", "ist", "das", "Wissen", "darum", "wichtig", ",", "dass", "Schusskanaele", "nicht", "immer", "geradlinig", "durch", "den", "Koerper", "verlaufen", ".", "Liegt", "ein", "Winkelschuss", ",", "ein", "gebrochener", "Schusskanal", "oder", "ein", "Kontur-", "oder", "Ringelschuss", "vor", ",", "koennen", "Organe", "verletzt", "werden", ",", "die", "nicht", "auf", "der", "direkten", "Verbindungslinie", "zwischen", "dem", "Einschuss", "und", "dem", "Ausschuss", "bzw", ".", "-", "bei", "einem", "Steckschuss", "-", "dem", "Einschuss", "und", "der", "Endlage", "des", "Projektils", "liegen", "." ]	[ "umlsterm" ]
Leistenbruchversorgung is an umlsterm, Leichen is an umlsterm, Universitaet is an umlsterm, topographische Anatomie is an umlsterm, Metaanalyse is an umlsterm, Komplikationen is an umlsterm, Technik is an umlsterm, Leistenbruchversorgung is an umlsterm, topographischen Anatomie is an umlsterm, Leistenbruchversorgung is an umlsterm	DerChirurg.60670807.ger.abstr_task0	Sentence: Zusammenfassung . In der Diskussion ueber Sinn und Unsinn einer laparoskopischen Leistenbruchversorgung wird immer wieder die Gefaehrdung wichtiger anatomischer Strukturen durch den extraperitonealen oder transabdominellen praeperitonealen Zugang angefuehrt . Anhand von eigenen anatomischen Praeparationen an acht Leichen des Anatomischen Institutes der Universitaet Ulm wird auf die topographische Anatomie der Leistenregion und seiner wichtigen Strukturen hingewiesen . Unsere Erkenntnisse werden zu einer Metaanalyse der bisher publizierten Komplikationen dieser neuen Technik der Leistenbruchversorgung in Bezug gesetzt . Unter genuegender Beruecksichtigung der topographischen Anatomie kann die Komplikationsrate der laparoskopischen Leistenbruchversorgung weiter deutlich gesenkt werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	Zusammenfassung . In der Diskussion ueber Sinn und Unsinn einer laparoskopischen Leistenbruchversorgung wird immer wieder die Gefaehrdung wichtiger anatomischer Strukturen durch den extraperitonealen oder transabdominellen praeperitonealen Zugang angefuehrt . Anhand von eigenen anatomischen Praeparationen an acht Leichen des Anatomischen Institutes der Universitaet Ulm wird auf die topographische Anatomie der Leistenregion und seiner wichtigen Strukturen hingewiesen . Unsere Erkenntnisse werden zu einer Metaanalyse der bisher publizierten Komplikationen dieser neuen Technik der Leistenbruchversorgung in Bezug gesetzt . Unter genuegender Beruecksichtigung der topographischen Anatomie kann die Komplikationsrate der laparoskopischen Leistenbruchversorgung weiter deutlich gesenkt werden .	[ "Zusammenfassung", ".", "In", "der", "Diskussion", "ueber", "Sinn", "und", "Unsinn", "einer", "laparoskopischen", "Leistenbruchversorgung", "wird", "immer", "wieder", "die", "Gefaehrdung", "wichtiger", "anatomischer", "Strukturen", "durch", "den", "extraperitonealen", "oder", "transabdominellen", "praeperitonealen", "Zugang", "angefuehrt", ".", "Anhand", "von", "eigenen", "anatomischen", "Praeparationen", "an", "acht", "Leichen", "des", "Anatomischen", "Institutes", "der", "Universitaet", "Ulm", "wird", "auf", "die", "topographische", "Anatomie", "der", "Leistenregion", "und", "seiner", "wichtigen", "Strukturen", "hingewiesen", ".", "Unsere", "Erkenntnisse", "werden", "zu", "einer", "Metaanalyse", "der", "bisher", "publizierten", "Komplikationen", "dieser", "neuen", "Technik", "der", "Leistenbruchversorgung", "in", "Bezug", "gesetzt", ".", "Unter", "genuegender", "Beruecksichtigung", "der", "topographischen", "Anatomie", "kann", "die", "Komplikationsrate", "der", "laparoskopischen", "Leistenbruchversorgung", "weiter", "deutlich", "gesenkt", "werden", "." ]	[ "umlsterm" ]
Leistenbruchversorgung is an umlsterm, Leichen is an umlsterm, Universitaet is an umlsterm, topographische Anatomie is an umlsterm, Metaanalyse is an umlsterm, Komplikationen is an umlsterm, Technik is an umlsterm, Leistenbruchversorgung is an umlsterm, topographischen Anatomie is an umlsterm, Leistenbruchversorgung is an umlsterm	DerChirurg.60670807.ger.abstr_task1	Sentence: Zusammenfassung . In der Diskussion ueber Sinn und Unsinn einer laparoskopischen Leistenbruchversorgung wird immer wieder die Gefaehrdung wichtiger anatomischer Strukturen durch den extraperitonealen oder transabdominellen praeperitonealen Zugang angefuehrt . Anhand von eigenen anatomischen Praeparationen an acht Leichen des Anatomischen Institutes der Universitaet Ulm wird auf die topographische Anatomie der Leistenregion und seiner wichtigen Strukturen hingewiesen . Unsere Erkenntnisse werden zu einer Metaanalyse der bisher publizierten Komplikationen dieser neuen Technik der Leistenbruchversorgung in Bezug gesetzt . Unter genuegender Beruecksichtigung der topographischen Anatomie kann die Komplikationsrate der laparoskopischen Leistenbruchversorgung weiter deutlich gesenkt werden . Instructions: please typing these entity words according to sentence: Leistenbruchversorgung, Leichen, Universitaet, topographische Anatomie, Metaanalyse, Komplikationen, Technik, Leistenbruchversorgung, topographischen Anatomie, Leistenbruchversorgung Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	Zusammenfassung . In der Diskussion ueber Sinn und Unsinn einer laparoskopischen Leistenbruchversorgung wird immer wieder die Gefaehrdung wichtiger anatomischer Strukturen durch den extraperitonealen oder transabdominellen praeperitonealen Zugang angefuehrt . Anhand von eigenen anatomischen Praeparationen an acht Leichen des Anatomischen Institutes der Universitaet Ulm wird auf die topographische Anatomie der Leistenregion und seiner wichtigen Strukturen hingewiesen . Unsere Erkenntnisse werden zu einer Metaanalyse der bisher publizierten Komplikationen dieser neuen Technik der Leistenbruchversorgung in Bezug gesetzt . Unter genuegender Beruecksichtigung der topographischen Anatomie kann die Komplikationsrate der laparoskopischen Leistenbruchversorgung weiter deutlich gesenkt werden .	[ "Zusammenfassung", ".", "In", "der", "Diskussion", "ueber", "Sinn", "und", "Unsinn", "einer", "laparoskopischen", "Leistenbruchversorgung", "wird", "immer", "wieder", "die", "Gefaehrdung", "wichtiger", "anatomischer", "Strukturen", "durch", "den", "extraperitonealen", "oder", "transabdominellen", "praeperitonealen", "Zugang", "angefuehrt", ".", "Anhand", "von", "eigenen", "anatomischen", "Praeparationen", "an", "acht", "Leichen", "des", "Anatomischen", "Institutes", "der", "Universitaet", "Ulm", "wird", "auf", "die", "topographische", "Anatomie", "der", "Leistenregion", "und", "seiner", "wichtigen", "Strukturen", "hingewiesen", ".", "Unsere", "Erkenntnisse", "werden", "zu", "einer", "Metaanalyse", "der", "bisher", "publizierten", "Komplikationen", "dieser", "neuen", "Technik", "der", "Leistenbruchversorgung", "in", "Bezug", "gesetzt", ".", "Unter", "genuegender", "Beruecksichtigung", "der", "topographischen", "Anatomie", "kann", "die", "Komplikationsrate", "der", "laparoskopischen", "Leistenbruchversorgung", "weiter", "deutlich", "gesenkt", "werden", "." ]	[ "umlsterm" ]
Leistenbruchversorgung, Leichen, Universitaet, topographische Anatomie, Metaanalyse, Komplikationen, Technik, Leistenbruchversorgung, topographischen Anatomie, Leistenbruchversorgung	DerChirurg.60670807.ger.abstr_task2	Sentence: Zusammenfassung . In der Diskussion ueber Sinn und Unsinn einer laparoskopischen Leistenbruchversorgung wird immer wieder die Gefaehrdung wichtiger anatomischer Strukturen durch den extraperitonealen oder transabdominellen praeperitonealen Zugang angefuehrt . Anhand von eigenen anatomischen Praeparationen an acht Leichen des Anatomischen Institutes der Universitaet Ulm wird auf die topographische Anatomie der Leistenregion und seiner wichtigen Strukturen hingewiesen . Unsere Erkenntnisse werden zu einer Metaanalyse der bisher publizierten Komplikationen dieser neuen Technik der Leistenbruchversorgung in Bezug gesetzt . Unter genuegender Beruecksichtigung der topographischen Anatomie kann die Komplikationsrate der laparoskopischen Leistenbruchversorgung weiter deutlich gesenkt werden . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	Zusammenfassung . In der Diskussion ueber Sinn und Unsinn einer laparoskopischen Leistenbruchversorgung wird immer wieder die Gefaehrdung wichtiger anatomischer Strukturen durch den extraperitonealen oder transabdominellen praeperitonealen Zugang angefuehrt . Anhand von eigenen anatomischen Praeparationen an acht Leichen des Anatomischen Institutes der Universitaet Ulm wird auf die topographische Anatomie der Leistenregion und seiner wichtigen Strukturen hingewiesen . Unsere Erkenntnisse werden zu einer Metaanalyse der bisher publizierten Komplikationen dieser neuen Technik der Leistenbruchversorgung in Bezug gesetzt . Unter genuegender Beruecksichtigung der topographischen Anatomie kann die Komplikationsrate der laparoskopischen Leistenbruchversorgung weiter deutlich gesenkt werden .	[ "Zusammenfassung", ".", "In", "der", "Diskussion", "ueber", "Sinn", "und", "Unsinn", "einer", "laparoskopischen", "Leistenbruchversorgung", "wird", "immer", "wieder", "die", "Gefaehrdung", "wichtiger", "anatomischer", "Strukturen", "durch", "den", "extraperitonealen", "oder", "transabdominellen", "praeperitonealen", "Zugang", "angefuehrt", ".", "Anhand", "von", "eigenen", "anatomischen", "Praeparationen", "an", "acht", "Leichen", "des", "Anatomischen", "Institutes", "der", "Universitaet", "Ulm", "wird", "auf", "die", "topographische", "Anatomie", "der", "Leistenregion", "und", "seiner", "wichtigen", "Strukturen", "hingewiesen", ".", "Unsere", "Erkenntnisse", "werden", "zu", "einer", "Metaanalyse", "der", "bisher", "publizierten", "Komplikationen", "dieser", "neuen", "Technik", "der", "Leistenbruchversorgung", "in", "Bezug", "gesetzt", ".", "Unter", "genuegender", "Beruecksichtigung", "der", "topographischen", "Anatomie", "kann", "die", "Komplikationsrate", "der", "laparoskopischen", "Leistenbruchversorgung", "weiter", "deutlich", "gesenkt", "werden", "." ]	[ "umlsterm" ]
Serum bactericidal activities is a Outcome_Physical, comparative pharmacokinetics is a Outcome_Other, meropenem is a Intervention_Pharmacological, imipenem is a Intervention_Pharmacological, serum bactericidal activities ( SBAs ) is a Outcome_Physical, Twelve healthy male volunteers is a Participant_Condition, imipenem plus 1 g of cilastatin is a Intervention_Pharmacological, 1 g of meropenem is a Intervention_Pharmacological, concentrations of the drugs in serum and urine is a Outcome_Physical, bioassay and high - pressure liquid chromatography . is a Outcome_Other, two - compartment model is a Intervention_Physical, noncompartmental technique is a Intervention_Physical, mean concentrations of imipenem and meropenem measured in serum is a Outcome_Physical, urinary recoveries is a Outcome_Physical, areas under the concentration - time curve is a Outcome_Physical, microdilution method of Reller and Stratton is a Outcome_Other, Mean reciprocal bactericidal titers is a Outcome_Physical, half - lives is a Outcome_Other, SBAs against clinically important pathogens is a Outcome_Physical	87737_task0	Sentence: Serum bactericidal activities and comparative pharmacokinetics of meropenem and imipenem-cilastatin . The pharmacokinetics and serum bactericidal activities ( SBAs ) of imipenem and meropenem were investigated in a randomized crossover study . Twelve healthy male volunteers received a constant 30-min infusion of either 1 g of imipenem plus 1 g of cilastatin or 1 g of meropenem . The concentrations of the drugs in serum and urine were determined by bioassay and high-pressure liquid chromatography . Pharmacokinetic parameters were based on an open two-compartment model and a noncompartmental technique . At the end of infusion , the mean concentrations of imipenem and meropenem measured in serum were 61.2 +/- 9.8 and 51.6 +/- 6.5 mg/liter , respectively ; urinary recoveries were 48.6 % +/- 8.2 % and 60.0 % +/- 6.5 % of the dose in 12 h , respectively ; and the areas under the concentration-time curve from time zero to infinity were 96.1 +/- 14.4 and 70.5 +/- 10.3 mg.h/liter , respectively ( P < or = 0.02 ) . Imipenem had a mean half-life of 66.7 +/- 10.4 min ; that of meropenem was 64.4 +/- 6.9 min . The volumes of distribution at steady state of imipenem and meropenem were 15.3 +/- 3.3 and 18.6 +/- 3.0 liters/70 kg , respectively , and the mean renal clearances per 1.73 m2 were 85.6 +/- 17.6 and 144.6 +/- 26.0 ml/min , respectively . Both antibiotics were well tolerated in this single-dose administration study . The SBAs were measured by the microdilution method of Reller and Stratton ( L. B. Reller and C. W. Stratton , J. Infect . Dis . 136:196-204 , 1977 ) against 40 clinically isolated strains . Mean reciprocal bactericidal titers were measured 1 and 6 h after administration . After 1 and 6 h the median SBAs for imipenem and meropenem , were 409 and 34.9 and 97.9 and 5.8 , respectively , against Staphylococcus aureus , 19.9 and 4.4 and 19.4 and 4.8 , respectively , against Pseudomonas aeruginosa , 34.3 and 2.2 and 232 and 15.5 , respectively , against Enterobacter cloacae , and 13.4 and 2.25 and 90.7 and 7.9 , respectively , against Proteus mirabilis . Both drugs had rather short biological elimination half-lives and a predominantly renal route of elimination . Both carbapenems revealed high SBAs against clinically important pathogens at 1 h ; meropenem had a higher SBA against E. cloacae and P. mirabilis , and the SBA of imipenem against S. aureus was greater than the SBA of meropenem . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Intervention_Physical, Participant_Condition, Outcome_Physical, Outcome_Other	[ "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "B-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Serum bactericidal activities and comparative pharmacokinetics of meropenem and imipenem-cilastatin . The pharmacokinetics and serum bactericidal activities ( SBAs ) of imipenem and meropenem were investigated in a randomized crossover study . Twelve healthy male volunteers received a constant 30-min infusion of either 1 g of imipenem plus 1 g of cilastatin or 1 g of meropenem . The concentrations of the drugs in serum and urine were determined by bioassay and high-pressure liquid chromatography . Pharmacokinetic parameters were based on an open two-compartment model and a noncompartmental technique . At the end of infusion , the mean concentrations of imipenem and meropenem measured in serum were 61.2 +/- 9.8 and 51.6 +/- 6.5 mg/liter , respectively ; urinary recoveries were 48.6 % +/- 8.2 % and 60.0 % +/- 6.5 % of the dose in 12 h , respectively ; and the areas under the concentration-time curve from time zero to infinity were 96.1 +/- 14.4 and 70.5 +/- 10.3 mg.h/liter , respectively ( P < or = 0.02 ) . Imipenem had a mean half-life of 66.7 +/- 10.4 min ; that of meropenem was 64.4 +/- 6.9 min . The volumes of distribution at steady state of imipenem and meropenem were 15.3 +/- 3.3 and 18.6 +/- 3.0 liters/70 kg , respectively , and the mean renal clearances per 1.73 m2 were 85.6 +/- 17.6 and 144.6 +/- 26.0 ml/min , respectively . Both antibiotics were well tolerated in this single-dose administration study . The SBAs were measured by the microdilution method of Reller and Stratton ( L. B. Reller and C. W. Stratton , J. Infect . Dis . 136:196-204 , 1977 ) against 40 clinically isolated strains . Mean reciprocal bactericidal titers were measured 1 and 6 h after administration . After 1 and 6 h the median SBAs for imipenem and meropenem , were 409 and 34.9 and 97.9 and 5.8 , respectively , against Staphylococcus aureus , 19.9 and 4.4 and 19.4 and 4.8 , respectively , against Pseudomonas aeruginosa , 34.3 and 2.2 and 232 and 15.5 , respectively , against Enterobacter cloacae , and 13.4 and 2.25 and 90.7 and 7.9 , respectively , against Proteus mirabilis . Both drugs had rather short biological elimination half-lives and a predominantly renal route of elimination . Both carbapenems revealed high SBAs against clinically important pathogens at 1 h ; meropenem had a higher SBA against E. cloacae and P. mirabilis , and the SBA of imipenem against S. aureus was greater than the SBA of meropenem .	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Serum bactericidal activities is a Outcome_Physical, comparative pharmacokinetics is a Outcome_Other, meropenem is a Intervention_Pharmacological, imipenem is a Intervention_Pharmacological, serum bactericidal activities ( SBAs ) is a Outcome_Physical, Twelve healthy male volunteers is a Participant_Condition, imipenem plus 1 g of cilastatin is a Intervention_Pharmacological, 1 g of meropenem is a Intervention_Pharmacological, concentrations of the drugs in serum and urine is a Outcome_Physical, bioassay and high - pressure liquid chromatography . is a Outcome_Other, two - compartment model is a Intervention_Physical, noncompartmental technique is a Intervention_Physical, mean concentrations of imipenem and meropenem measured in serum is a Outcome_Physical, urinary recoveries is a Outcome_Physical, areas under the concentration - time curve is a Outcome_Physical, microdilution method of Reller and Stratton is a Outcome_Other, Mean reciprocal bactericidal titers is a Outcome_Physical, half - lives is a Outcome_Other, SBAs against clinically important pathogens is a Outcome_Physical	87737_task1	Sentence: Serum bactericidal activities and comparative pharmacokinetics of meropenem and imipenem-cilastatin . The pharmacokinetics and serum bactericidal activities ( SBAs ) of imipenem and meropenem were investigated in a randomized crossover study . Twelve healthy male volunteers received a constant 30-min infusion of either 1 g of imipenem plus 1 g of cilastatin or 1 g of meropenem . The concentrations of the drugs in serum and urine were determined by bioassay and high-pressure liquid chromatography . Pharmacokinetic parameters were based on an open two-compartment model and a noncompartmental technique . At the end of infusion , the mean concentrations of imipenem and meropenem measured in serum were 61.2 +/- 9.8 and 51.6 +/- 6.5 mg/liter , respectively ; urinary recoveries were 48.6 % +/- 8.2 % and 60.0 % +/- 6.5 % of the dose in 12 h , respectively ; and the areas under the concentration-time curve from time zero to infinity were 96.1 +/- 14.4 and 70.5 +/- 10.3 mg.h/liter , respectively ( P < or = 0.02 ) . Imipenem had a mean half-life of 66.7 +/- 10.4 min ; that of meropenem was 64.4 +/- 6.9 min . The volumes of distribution at steady state of imipenem and meropenem were 15.3 +/- 3.3 and 18.6 +/- 3.0 liters/70 kg , respectively , and the mean renal clearances per 1.73 m2 were 85.6 +/- 17.6 and 144.6 +/- 26.0 ml/min , respectively . Both antibiotics were well tolerated in this single-dose administration study . The SBAs were measured by the microdilution method of Reller and Stratton ( L. B. Reller and C. W. Stratton , J. Infect . Dis . 136:196-204 , 1977 ) against 40 clinically isolated strains . Mean reciprocal bactericidal titers were measured 1 and 6 h after administration . After 1 and 6 h the median SBAs for imipenem and meropenem , were 409 and 34.9 and 97.9 and 5.8 , respectively , against Staphylococcus aureus , 19.9 and 4.4 and 19.4 and 4.8 , respectively , against Pseudomonas aeruginosa , 34.3 and 2.2 and 232 and 15.5 , respectively , against Enterobacter cloacae , and 13.4 and 2.25 and 90.7 and 7.9 , respectively , against Proteus mirabilis . Both drugs had rather short biological elimination half-lives and a predominantly renal route of elimination . Both carbapenems revealed high SBAs against clinically important pathogens at 1 h ; meropenem had a higher SBA against E. cloacae and P. mirabilis , and the SBA of imipenem against S. aureus was greater than the SBA of meropenem . Instructions: please typing these entity words according to sentence: Serum bactericidal activities, comparative pharmacokinetics, meropenem, imipenem, serum bactericidal activities ( SBAs ), Twelve healthy male volunteers, imipenem plus 1 g of cilastatin, 1 g of meropenem, concentrations of the drugs in serum and urine, bioassay and high - pressure liquid chromatography ., two - compartment model, noncompartmental technique, mean concentrations of imipenem and meropenem measured in serum, urinary recoveries, areas under the concentration - time curve, microdilution method of Reller and Stratton, Mean reciprocal bactericidal titers, half - lives, SBAs against clinically important pathogens Options: Intervention_Pharmacological, Intervention_Physical, Participant_Condition, Outcome_Physical, Outcome_Other	[ "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "B-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Serum bactericidal activities and comparative pharmacokinetics of meropenem and imipenem-cilastatin . The pharmacokinetics and serum bactericidal activities ( SBAs ) of imipenem and meropenem were investigated in a randomized crossover study . Twelve healthy male volunteers received a constant 30-min infusion of either 1 g of imipenem plus 1 g of cilastatin or 1 g of meropenem . The concentrations of the drugs in serum and urine were determined by bioassay and high-pressure liquid chromatography . Pharmacokinetic parameters were based on an open two-compartment model and a noncompartmental technique . At the end of infusion , the mean concentrations of imipenem and meropenem measured in serum were 61.2 +/- 9.8 and 51.6 +/- 6.5 mg/liter , respectively ; urinary recoveries were 48.6 % +/- 8.2 % and 60.0 % +/- 6.5 % of the dose in 12 h , respectively ; and the areas under the concentration-time curve from time zero to infinity were 96.1 +/- 14.4 and 70.5 +/- 10.3 mg.h/liter , respectively ( P < or = 0.02 ) . Imipenem had a mean half-life of 66.7 +/- 10.4 min ; that of meropenem was 64.4 +/- 6.9 min . The volumes of distribution at steady state of imipenem and meropenem were 15.3 +/- 3.3 and 18.6 +/- 3.0 liters/70 kg , respectively , and the mean renal clearances per 1.73 m2 were 85.6 +/- 17.6 and 144.6 +/- 26.0 ml/min , respectively . Both antibiotics were well tolerated in this single-dose administration study . The SBAs were measured by the microdilution method of Reller and Stratton ( L. B. Reller and C. W. Stratton , J. Infect . Dis . 136:196-204 , 1977 ) against 40 clinically isolated strains . Mean reciprocal bactericidal titers were measured 1 and 6 h after administration . After 1 and 6 h the median SBAs for imipenem and meropenem , were 409 and 34.9 and 97.9 and 5.8 , respectively , against Staphylococcus aureus , 19.9 and 4.4 and 19.4 and 4.8 , respectively , against Pseudomonas aeruginosa , 34.3 and 2.2 and 232 and 15.5 , respectively , against Enterobacter cloacae , and 13.4 and 2.25 and 90.7 and 7.9 , respectively , against Proteus mirabilis . Both drugs had rather short biological elimination half-lives and a predominantly renal route of elimination . Both carbapenems revealed high SBAs against clinically important pathogens at 1 h ; meropenem had a higher SBA against E. cloacae and P. mirabilis , and the SBA of imipenem against S. aureus was greater than the SBA of meropenem .	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Serum bactericidal activities, comparative pharmacokinetics, meropenem, imipenem, serum bactericidal activities ( SBAs ), Twelve healthy male volunteers, imipenem plus 1 g of cilastatin, 1 g of meropenem, concentrations of the drugs in serum and urine, bioassay and high - pressure liquid chromatography ., two - compartment model, noncompartmental technique, mean concentrations of imipenem and meropenem measured in serum, urinary recoveries, areas under the concentration - time curve, microdilution method of Reller and Stratton, Mean reciprocal bactericidal titers, half - lives, SBAs against clinically important pathogens	87737_task2	Sentence: Serum bactericidal activities and comparative pharmacokinetics of meropenem and imipenem-cilastatin . The pharmacokinetics and serum bactericidal activities ( SBAs ) of imipenem and meropenem were investigated in a randomized crossover study . Twelve healthy male volunteers received a constant 30-min infusion of either 1 g of imipenem plus 1 g of cilastatin or 1 g of meropenem . The concentrations of the drugs in serum and urine were determined by bioassay and high-pressure liquid chromatography . Pharmacokinetic parameters were based on an open two-compartment model and a noncompartmental technique . At the end of infusion , the mean concentrations of imipenem and meropenem measured in serum were 61.2 +/- 9.8 and 51.6 +/- 6.5 mg/liter , respectively ; urinary recoveries were 48.6 % +/- 8.2 % and 60.0 % +/- 6.5 % of the dose in 12 h , respectively ; and the areas under the concentration-time curve from time zero to infinity were 96.1 +/- 14.4 and 70.5 +/- 10.3 mg.h/liter , respectively ( P < or = 0.02 ) . Imipenem had a mean half-life of 66.7 +/- 10.4 min ; that of meropenem was 64.4 +/- 6.9 min . The volumes of distribution at steady state of imipenem and meropenem were 15.3 +/- 3.3 and 18.6 +/- 3.0 liters/70 kg , respectively , and the mean renal clearances per 1.73 m2 were 85.6 +/- 17.6 and 144.6 +/- 26.0 ml/min , respectively . Both antibiotics were well tolerated in this single-dose administration study . The SBAs were measured by the microdilution method of Reller and Stratton ( L. B. Reller and C. W. Stratton , J. Infect . Dis . 136:196-204 , 1977 ) against 40 clinically isolated strains . Mean reciprocal bactericidal titers were measured 1 and 6 h after administration . After 1 and 6 h the median SBAs for imipenem and meropenem , were 409 and 34.9 and 97.9 and 5.8 , respectively , against Staphylococcus aureus , 19.9 and 4.4 and 19.4 and 4.8 , respectively , against Pseudomonas aeruginosa , 34.3 and 2.2 and 232 and 15.5 , respectively , against Enterobacter cloacae , and 13.4 and 2.25 and 90.7 and 7.9 , respectively , against Proteus mirabilis . Both drugs had rather short biological elimination half-lives and a predominantly renal route of elimination . Both carbapenems revealed high SBAs against clinically important pathogens at 1 h ; meropenem had a higher SBA against E. cloacae and P. mirabilis , and the SBA of imipenem against S. aureus was greater than the SBA of meropenem . Instructions: please extract entity words from the input sentence	[ "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "B-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Serum bactericidal activities and comparative pharmacokinetics of meropenem and imipenem-cilastatin . The pharmacokinetics and serum bactericidal activities ( SBAs ) of imipenem and meropenem were investigated in a randomized crossover study . Twelve healthy male volunteers received a constant 30-min infusion of either 1 g of imipenem plus 1 g of cilastatin or 1 g of meropenem . The concentrations of the drugs in serum and urine were determined by bioassay and high-pressure liquid chromatography . Pharmacokinetic parameters were based on an open two-compartment model and a noncompartmental technique . At the end of infusion , the mean concentrations of imipenem and meropenem measured in serum were 61.2 +/- 9.8 and 51.6 +/- 6.5 mg/liter , respectively ; urinary recoveries were 48.6 % +/- 8.2 % and 60.0 % +/- 6.5 % of the dose in 12 h , respectively ; and the areas under the concentration-time curve from time zero to infinity were 96.1 +/- 14.4 and 70.5 +/- 10.3 mg.h/liter , respectively ( P < or = 0.02 ) . Imipenem had a mean half-life of 66.7 +/- 10.4 min ; that of meropenem was 64.4 +/- 6.9 min . The volumes of distribution at steady state of imipenem and meropenem were 15.3 +/- 3.3 and 18.6 +/- 3.0 liters/70 kg , respectively , and the mean renal clearances per 1.73 m2 were 85.6 +/- 17.6 and 144.6 +/- 26.0 ml/min , respectively . Both antibiotics were well tolerated in this single-dose administration study . The SBAs were measured by the microdilution method of Reller and Stratton ( L. B. Reller and C. W. Stratton , J. Infect . Dis . 136:196-204 , 1977 ) against 40 clinically isolated strains . Mean reciprocal bactericidal titers were measured 1 and 6 h after administration . After 1 and 6 h the median SBAs for imipenem and meropenem , were 409 and 34.9 and 97.9 and 5.8 , respectively , against Staphylococcus aureus , 19.9 and 4.4 and 19.4 and 4.8 , respectively , against Pseudomonas aeruginosa , 34.3 and 2.2 and 232 and 15.5 , respectively , against Enterobacter cloacae , and 13.4 and 2.25 and 90.7 and 7.9 , respectively , against Proteus mirabilis . Both drugs had rather short biological elimination half-lives and a predominantly renal route of elimination . Both carbapenems revealed high SBAs against clinically important pathogens at 1 h ; meropenem had a higher SBA against E. cloacae and P. mirabilis , and the SBA of imipenem against S. aureus was greater than the SBA of meropenem .	[ "Serum", "bactericidal", "activities", "and", "comparative", "pharmacokinetics", "of", "meropenem", "and", "imipenem", "-", "cilastatin", ".", "The", "pharmacokinetics", "and", "serum", "bactericidal", "activities", "(", "SBAs", ")", "of", "imipenem", "and", "meropenem", "were", "investigated", "in", "a", "randomized", "crossover", "study", ".", "Twelve", "healthy", "male", "volunteers", "received", "a", "constant", "30-min", "infusion", "of", "either", "1", "g", "of", "imipenem", "plus", "1", "g", "of", "cilastatin", "or", "1", "g", "of", "meropenem", ".", "The", "concentrations", "of", "the", "drugs", "in", "serum", "and", "urine", "were", "determined", "by", "bioassay", "and", "high", "-", "pressure", "liquid", "chromatography", ".", "Pharmacokinetic", "parameters", "were", "based", "on", "an", "open", "two", "-", "compartment", "model", "and", "a", "noncompartmental", "technique", ".", "At", "the", "end", "of", "infusion", ",", "the", "mean", "concentrations", "of", "imipenem", "and", "meropenem", "measured", "in", "serum", "were", "61.2", "+", "/-", "9.8", "and", "51.6", "+", "/-", "6.5", "mg", "/", "liter", ",", "respectively", ";", "urinary", "recoveries", "were", "48.6", "%", "+", "/-", "8.2", "%", "and", "60.0", "%", "+", "/-", "6.5", "%", "of", "the", "dose", "in", "12", "h", ",", "respectively", ";", "and", "the", "areas", "under", "the", "concentration", "-", "time", "curve", "from", "time", "zero", "to", "infinity", "were", "96.1", "+", "/-", "14.4", "and", "70.5", "+", "/-", "10.3", "mg.h", "/", "liter", ",", "respectively", "(", "P", "<", "or", "=", "0.02", ")", ".", "Imipenem", "had", "a", "mean", "half", "-", "life", "of", "66.7", "+", "/-", "10.4", "min", ";", "that", "of", "meropenem", "was", "64.4", "+", "/-", "6.9", "min", ".", "The", "volumes", "of", "distribution", "at", "steady", "state", "of", "imipenem", "and", "meropenem", "were", "15.3", "+", "/-", "3.3", "and", "18.6", "+", "/-", "3.0", "liters/70", "kg", ",", "respectively", ",", "and", "the", "mean", "renal", "clearances", "per", "1.73", "m2", "were", "85.6", "+", "/-", "17.6", "and", "144.6", "+", "/-", "26.0", "ml", "/", "min", ",", "respectively", ".", "Both", "antibiotics", "were", "well", "tolerated", "in", "this", "single", "-", "dose", "administration", "study", ".", "The", "SBAs", "were", "measured", "by", "the", "microdilution", "method", "of", "Reller", "and", "Stratton", "(", "L.", "B.", "Reller", "and", "C.", "W.", "Stratton", ",", "J.", "Infect", ".", "Dis", ".", "136:196", "-", "204", ",", "1977", ")", "against", "40", "clinically", "isolated", "strains", ".", "Mean", "reciprocal", "bactericidal", "titers", "were", "measured", "1", "and", "6", "h", "after", "administration", ".", "After", "1", "and", "6", "h", "the", "median", "SBAs", "for", "imipenem", "and", "meropenem", ",", "were", "409", "and", "34.9", "and", "97.9", "and", "5.8", ",", "respectively", ",", "against", "Staphylococcus", "aureus", ",", "19.9", "and", "4.4", "and", "19.4", "and", "4.8", ",", "respectively", ",", "against", "Pseudomonas", "aeruginosa", ",", "34.3", "and", "2.2", "and", "232", "and", "15.5", ",", "respectively", ",", "against", "Enterobacter", "cloacae", ",", "and", "13.4", "and", "2.25", "and", "90.7", "and", "7.9", ",", "respectively", ",", "against", "Proteus", "mirabilis", ".", "Both", "drugs", "had", "rather", "short", "biological", "elimination", "half", "-", "lives", "and", "a", "predominantly", "renal", "route", "of", "elimination", ".", "Both", "carbapenems", "revealed", "high", "SBAs", "against", "clinically", "important", "pathogens", "at", "1", "h", ";", "meropenem", "had", "a", "higher", "SBA", "against", "E.", "cloacae", "and", "P.", "mirabilis", ",", "and", "the", "SBA", "of", "imipenem", "against", "S.", "aureus", "was", "greater", "than", "the", "SBA", "of", "meropenem", "." ]	[ "Outcome_Physical", "Outcome_Other", "Intervention_Physical", "Intervention_Pharmacological", "Participant_Condition" ]
Lippendefekten is an umlsterm, Mundsphinkters is an umlsterm, Literatur is an umlsterm, Techniken is an umlsterm, Wiederherstellung is an umlsterm, Lippendefekten is an umlsterm, Lippen is an umlsterm, Arbeit is an umlsterm, Lippenrotdefekte is an umlsterm, Lippen is an umlsterm	HNO.00480517.ger.abstr_task0	Sentence: Die Rekonstruktion von Lippendefekten stellt eine Herausforderung fuer den Operateur dar . Neben den guten aesthetischen Ergebnissen ist die Erhaltung der Funktionen des Mundsphinkters erforderlich . In der Literatur werden verschiedene Techniken und Modifikationen zur Wiederherstellung von Lippendefekten angegeben . Es bleibt dem Operateur ueberlassen , abhaengig von der Lokalisation , Groesse und Tiefe des Defekts , das Rekonstruktionsverfahren mit den besten funktionellen und aesthetischen Ergebnissen auszuwaehlen . Die Unterteilung der Lippen in aesthetische Untereinheiten kann sehr vorteilhaft bei der Planung der Rekonstruktion sein . Die Oberlippe wird in 3 aesthetische Untereinheiten unterteilt 2 laterale Untereinheiten und 1 mediane , : das Philtrum . Die Unterlippe besteht aus einer aesthetischen Untereinheit . In dieser Arbeit werden bewaehrte Rekonstruktionstechniken erlaeutert und ein Konzept vorgestellt , das die Wahl des jeweils adaequaten Verfahrens erleichtern soll . In diesem Konzept unterscheiden wir reine Lippenrotdefekte von partiellen und kompletten Defekten der Lippen . Die kompletten Defekte werden bei der Unterlippe in Defekte bis zu 1/3 , 1/3 bis 2/3 der Unterlippenbreite und zwischen 2/3 und totalem Substanzverlust unterteilt . Bei der Oberlippe unterscheiden wir isolierte Defekte der zentralen und lateralen Untereinheit und kombinierte Defekte der zentralen und lateralen Untereinheit . Wichtige Operationsprinzipien sowie die Vor- und Nachteile verschiedener Rekonstruktionstechniken werden diskutiert . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Die Rekonstruktion von Lippendefekten stellt eine Herausforderung fuer den Operateur dar . Neben den guten aesthetischen Ergebnissen ist die Erhaltung der Funktionen des Mundsphinkters erforderlich . In der Literatur werden verschiedene Techniken und Modifikationen zur Wiederherstellung von Lippendefekten angegeben . Es bleibt dem Operateur ueberlassen , abhaengig von der Lokalisation , Groesse und Tiefe des Defekts , das Rekonstruktionsverfahren mit den besten funktionellen und aesthetischen Ergebnissen auszuwaehlen . Die Unterteilung der Lippen in aesthetische Untereinheiten kann sehr vorteilhaft bei der Planung der Rekonstruktion sein . Die Oberlippe wird in 3 aesthetische Untereinheiten unterteilt 2 laterale Untereinheiten und 1 mediane , : das Philtrum . Die Unterlippe besteht aus einer aesthetischen Untereinheit . In dieser Arbeit werden bewaehrte Rekonstruktionstechniken erlaeutert und ein Konzept vorgestellt , das die Wahl des jeweils adaequaten Verfahrens erleichtern soll . In diesem Konzept unterscheiden wir reine Lippenrotdefekte von partiellen und kompletten Defekten der Lippen . Die kompletten Defekte werden bei der Unterlippe in Defekte bis zu 1/3 , 1/3 bis 2/3 der Unterlippenbreite und zwischen 2/3 und totalem Substanzverlust unterteilt . Bei der Oberlippe unterscheiden wir isolierte Defekte der zentralen und lateralen Untereinheit und kombinierte Defekte der zentralen und lateralen Untereinheit . Wichtige Operationsprinzipien sowie die Vor- und Nachteile verschiedener Rekonstruktionstechniken werden diskutiert .	[ "Die", "Rekonstruktion", "von", "Lippendefekten", "stellt", "eine", "Herausforderung", "fuer", "den", "Operateur", "dar", ".", "Neben", "den", "guten", "aesthetischen", "Ergebnissen", "ist", "die", "Erhaltung", "der", "Funktionen", "des", "Mundsphinkters", "erforderlich", ".", "In", "der", "Literatur", "werden", "verschiedene", "Techniken", "und", "Modifikationen", "zur", "Wiederherstellung", "von", "Lippendefekten", "angegeben", ".", "Es", "bleibt", "dem", "Operateur", "ueberlassen", ",", "abhaengig", "von", "der", "Lokalisation", ",", "Groesse", "und", "Tiefe", "des", "Defekts", ",", "das", "Rekonstruktionsverfahren", "mit", "den", "besten", "funktionellen", "und", "aesthetischen", "Ergebnissen", "auszuwaehlen", ".", "Die", "Unterteilung", "der", "Lippen", "in", "aesthetische", "Untereinheiten", "kann", "sehr", "vorteilhaft", "bei", "der", "Planung", "der", "Rekonstruktion", "sein", ".", "Die", "Oberlippe", "wird", "in", "3", "aesthetische", "Untereinheiten", "unterteilt", "2", "laterale", "Untereinheiten", "und", "1", "mediane", ",", ":", "das", "Philtrum", ".", "Die", "Unterlippe", "besteht", "aus", "einer", "aesthetischen", "Untereinheit", ".", "In", "dieser", "Arbeit", "werden", "bewaehrte", "Rekonstruktionstechniken", "erlaeutert", "und", "ein", "Konzept", "vorgestellt", ",", "das", "die", "Wahl", "des", "jeweils", "adaequaten", "Verfahrens", "erleichtern", "soll", ".", "In", "diesem", "Konzept", "unterscheiden", "wir", "reine", "Lippenrotdefekte", "von", "partiellen", "und", "kompletten", "Defekten", "der", "Lippen", ".", "Die", "kompletten", "Defekte", "werden", "bei", "der", "Unterlippe", "in", "Defekte", "bis", "zu", "1/3", ",", "1/3", "bis", "2/3", "der", "Unterlippenbreite", "und", "zwischen", "2/3", "und", "totalem", "Substanzverlust", "unterteilt", ".", "Bei", "der", "Oberlippe", "unterscheiden", "wir", "isolierte", "Defekte", "der", "zentralen", "und", "lateralen", "Untereinheit", "und", "kombinierte", "Defekte", "der", "zentralen", "und", "lateralen", "Untereinheit", ".", "Wichtige", "Operationsprinzipien", "sowie", "die", "Vor-", "und", "Nachteile", "verschiedener", "Rekonstruktionstechniken", "werden", "diskutiert", "." ]	[ "umlsterm" ]
Lippendefekten is an umlsterm, Mundsphinkters is an umlsterm, Literatur is an umlsterm, Techniken is an umlsterm, Wiederherstellung is an umlsterm, Lippendefekten is an umlsterm, Lippen is an umlsterm, Arbeit is an umlsterm, Lippenrotdefekte is an umlsterm, Lippen is an umlsterm	HNO.00480517.ger.abstr_task1	Sentence: Die Rekonstruktion von Lippendefekten stellt eine Herausforderung fuer den Operateur dar . Neben den guten aesthetischen Ergebnissen ist die Erhaltung der Funktionen des Mundsphinkters erforderlich . In der Literatur werden verschiedene Techniken und Modifikationen zur Wiederherstellung von Lippendefekten angegeben . Es bleibt dem Operateur ueberlassen , abhaengig von der Lokalisation , Groesse und Tiefe des Defekts , das Rekonstruktionsverfahren mit den besten funktionellen und aesthetischen Ergebnissen auszuwaehlen . Die Unterteilung der Lippen in aesthetische Untereinheiten kann sehr vorteilhaft bei der Planung der Rekonstruktion sein . Die Oberlippe wird in 3 aesthetische Untereinheiten unterteilt 2 laterale Untereinheiten und 1 mediane , : das Philtrum . Die Unterlippe besteht aus einer aesthetischen Untereinheit . In dieser Arbeit werden bewaehrte Rekonstruktionstechniken erlaeutert und ein Konzept vorgestellt , das die Wahl des jeweils adaequaten Verfahrens erleichtern soll . In diesem Konzept unterscheiden wir reine Lippenrotdefekte von partiellen und kompletten Defekten der Lippen . Die kompletten Defekte werden bei der Unterlippe in Defekte bis zu 1/3 , 1/3 bis 2/3 der Unterlippenbreite und zwischen 2/3 und totalem Substanzverlust unterteilt . Bei der Oberlippe unterscheiden wir isolierte Defekte der zentralen und lateralen Untereinheit und kombinierte Defekte der zentralen und lateralen Untereinheit . Wichtige Operationsprinzipien sowie die Vor- und Nachteile verschiedener Rekonstruktionstechniken werden diskutiert . Instructions: please typing these entity words according to sentence: Lippendefekten, Mundsphinkters, Literatur, Techniken, Wiederherstellung, Lippendefekten, Lippen, Arbeit, Lippenrotdefekte, Lippen Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Die Rekonstruktion von Lippendefekten stellt eine Herausforderung fuer den Operateur dar . Neben den guten aesthetischen Ergebnissen ist die Erhaltung der Funktionen des Mundsphinkters erforderlich . In der Literatur werden verschiedene Techniken und Modifikationen zur Wiederherstellung von Lippendefekten angegeben . Es bleibt dem Operateur ueberlassen , abhaengig von der Lokalisation , Groesse und Tiefe des Defekts , das Rekonstruktionsverfahren mit den besten funktionellen und aesthetischen Ergebnissen auszuwaehlen . Die Unterteilung der Lippen in aesthetische Untereinheiten kann sehr vorteilhaft bei der Planung der Rekonstruktion sein . Die Oberlippe wird in 3 aesthetische Untereinheiten unterteilt 2 laterale Untereinheiten und 1 mediane , : das Philtrum . Die Unterlippe besteht aus einer aesthetischen Untereinheit . In dieser Arbeit werden bewaehrte Rekonstruktionstechniken erlaeutert und ein Konzept vorgestellt , das die Wahl des jeweils adaequaten Verfahrens erleichtern soll . In diesem Konzept unterscheiden wir reine Lippenrotdefekte von partiellen und kompletten Defekten der Lippen . Die kompletten Defekte werden bei der Unterlippe in Defekte bis zu 1/3 , 1/3 bis 2/3 der Unterlippenbreite und zwischen 2/3 und totalem Substanzverlust unterteilt . Bei der Oberlippe unterscheiden wir isolierte Defekte der zentralen und lateralen Untereinheit und kombinierte Defekte der zentralen und lateralen Untereinheit . Wichtige Operationsprinzipien sowie die Vor- und Nachteile verschiedener Rekonstruktionstechniken werden diskutiert .	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Lippendefekten, Mundsphinkters, Literatur, Techniken, Wiederherstellung, Lippendefekten, Lippen, Arbeit, Lippenrotdefekte, Lippen	HNO.00480517.ger.abstr_task2	Sentence: Die Rekonstruktion von Lippendefekten stellt eine Herausforderung fuer den Operateur dar . Neben den guten aesthetischen Ergebnissen ist die Erhaltung der Funktionen des Mundsphinkters erforderlich . In der Literatur werden verschiedene Techniken und Modifikationen zur Wiederherstellung von Lippendefekten angegeben . Es bleibt dem Operateur ueberlassen , abhaengig von der Lokalisation , Groesse und Tiefe des Defekts , das Rekonstruktionsverfahren mit den besten funktionellen und aesthetischen Ergebnissen auszuwaehlen . Die Unterteilung der Lippen in aesthetische Untereinheiten kann sehr vorteilhaft bei der Planung der Rekonstruktion sein . Die Oberlippe wird in 3 aesthetische Untereinheiten unterteilt 2 laterale Untereinheiten und 1 mediane , : das Philtrum . Die Unterlippe besteht aus einer aesthetischen Untereinheit . In dieser Arbeit werden bewaehrte Rekonstruktionstechniken erlaeutert und ein Konzept vorgestellt , das die Wahl des jeweils adaequaten Verfahrens erleichtern soll . In diesem Konzept unterscheiden wir reine Lippenrotdefekte von partiellen und kompletten Defekten der Lippen . Die kompletten Defekte werden bei der Unterlippe in Defekte bis zu 1/3 , 1/3 bis 2/3 der Unterlippenbreite und zwischen 2/3 und totalem Substanzverlust unterteilt . Bei der Oberlippe unterscheiden wir isolierte Defekte der zentralen und lateralen Untereinheit und kombinierte Defekte der zentralen und lateralen Untereinheit . Wichtige Operationsprinzipien sowie die Vor- und Nachteile verschiedener Rekonstruktionstechniken werden diskutiert . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Die Rekonstruktion von Lippendefekten stellt eine Herausforderung fuer den Operateur dar . Neben den guten aesthetischen Ergebnissen ist die Erhaltung der Funktionen des Mundsphinkters erforderlich . In der Literatur werden verschiedene Techniken und Modifikationen zur Wiederherstellung von Lippendefekten angegeben . Es bleibt dem Operateur ueberlassen , abhaengig von der Lokalisation , Groesse und Tiefe des Defekts , das Rekonstruktionsverfahren mit den besten funktionellen und aesthetischen Ergebnissen auszuwaehlen . Die Unterteilung der Lippen in aesthetische Untereinheiten kann sehr vorteilhaft bei der Planung der Rekonstruktion sein . Die Oberlippe wird in 3 aesthetische Untereinheiten unterteilt 2 laterale Untereinheiten und 1 mediane , : das Philtrum . Die Unterlippe besteht aus einer aesthetischen Untereinheit . In dieser Arbeit werden bewaehrte Rekonstruktionstechniken erlaeutert und ein Konzept vorgestellt , das die Wahl des jeweils adaequaten Verfahrens erleichtern soll . In diesem Konzept unterscheiden wir reine Lippenrotdefekte von partiellen und kompletten Defekten der Lippen . Die kompletten Defekte werden bei der Unterlippe in Defekte bis zu 1/3 , 1/3 bis 2/3 der Unterlippenbreite und zwischen 2/3 und totalem Substanzverlust unterteilt . Bei der Oberlippe unterscheiden wir isolierte Defekte der zentralen und lateralen Untereinheit und kombinierte Defekte der zentralen und lateralen Untereinheit . Wichtige Operationsprinzipien sowie die Vor- und Nachteile verschiedener Rekonstruktionstechniken werden diskutiert .	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Catalpol is a CHEMICAL, oxygen is a CHEMICAL, catalpol is a CHEMICAL, Catalpol is a CHEMICAL, monocyte chemotactic protein-1 is a GENE-Y, MCP-1 is a GENE-Y, tumor necrosis factor - α is a GENE-Y, TNF - α is a GENE-Y, inducible NO synthase is a GENE-Y, iNOS is a GENE-Y, receptor for AGE is a GENE-Y, RAGE is a GENE-Y, NF - κB is a GENE-N, catalpol is a CHEMICAL, AP-1 is a GENE-Y, Catalpol is a CHEMICAL, mitogen activated protein ( MAP ) kinases is a GENE-N, IκBα is a GENE-Y, oxygen is a CHEMICAL, catalpol is a CHEMICAL, NADPH oxidase is a GENE-N, catalpol is a CHEMICAL, NF - κB is a GENE-N, catalpol is a CHEMICAL	26385_task0	Sentence: Catalpol suppresses advanced glycation end-products-induced inflammatory responses through inhibition of reactive oxygen species in human monocytic THP-1 cells. Advanced glycation end-products (AGEs) play a pivotal role in the development of diabetic complications by inducing inflammation. We previously reported that the fresh roots of Rehmannia glutinosa Libosch., which have been used for the treatment of diabetes in traditional Korean medicine, also have the potential to suppress AGE-mediated inflammatory response in THP-1 cells. In the present study, we isolated catalpol from R. glutinosa, and examined whether it has anti-inflammatory effects on AGE-stimulated THP-1 cells. Catalpol reduced the expression of pro-inflammatory mediates, such as monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor-α (TNF-α), inducible NO synthase (iNOS), and receptor for AGE (RAGE). Promoter and electromobility shift assays showed that transcriptional activation of NF-κB was significantly reduced by catalpol treatment, while AP-1 was not. Catalpol also suppressed AGE-induced phosphorylation of mitogen activated protein (MAP) kinases, degradation of IκBα and the nuclear localization of NF-κB. Moreover, the production of intracellular reactive oxygen species (ROS) elicited by AGE was also suppressed by catalpol treatment, through dual action of reducing ROS itself and inhibiting NADPH oxidase activity. Our findings indicate that catalpol suppresses AGE-mediated inflammation by inhibiting ROS production and NF-κB activity. We suggest that catalpol, a major constituent of the fresh roots of R. glutinosa, contributes to the prevention of AGE-mediated diabetic complications. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N, GENE-Y, CHEMICAL	[ "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Catalpol suppresses advanced glycation end-products-induced inflammatory responses through inhibition of reactive oxygen species in human monocytic THP-1 cells. Advanced glycation end-products (AGEs) play a pivotal role in the development of diabetic complications by inducing inflammation. We previously reported that the fresh roots of Rehmannia glutinosa Libosch., which have been used for the treatment of diabetes in traditional Korean medicine, also have the potential to suppress AGE-mediated inflammatory response in THP-1 cells. In the present study, we isolated catalpol from R. glutinosa, and examined whether it has anti-inflammatory effects on AGE-stimulated THP-1 cells. Catalpol reduced the expression of pro-inflammatory mediates, such as monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor-α (TNF-α), inducible NO synthase (iNOS), and receptor for AGE (RAGE). Promoter and electromobility shift assays showed that transcriptional activation of NF-κB was significantly reduced by catalpol treatment, while AP-1 was not. Catalpol also suppressed AGE-induced phosphorylation of mitogen activated protein (MAP) kinases, degradation of IκBα and the nuclear localization of NF-κB. Moreover, the production of intracellular reactive oxygen species (ROS) elicited by AGE was also suppressed by catalpol treatment, through dual action of reducing ROS itself and inhibiting NADPH oxidase activity. Our findings indicate that catalpol suppresses AGE-mediated inflammation by inhibiting ROS production and NF-κB activity. We suggest that catalpol, a major constituent of the fresh roots of R. glutinosa, contributes to the prevention of AGE-mediated diabetic complications.	[ "Catalpol", "suppresses", "advanced", "glycation", "end", "-", "products", "-", "induced", "inflammatory", "responses", "through", "inhibition", "of", "reactive", "oxygen", "species", "in", "human", "monocytic", "THP-1", "cells", ".", "\n", "Advanced", "glycation", "end", "-", "products", "(", "AGEs", ")", "play", "a", "pivotal", "role", "in", "the", "development", "of", "diabetic", "complications", "by", "inducing", "inflammation", ".", "We", "previously", "reported", "that", "the", "fresh", "roots", "of", "Rehmannia", "glutinosa", "Libosch", ".", ",", "which", "have", "been", "used", "for", "the", "treatment", "of", "diabetes", "in", "traditional", "Korean", "medicine", ",", "also", "have", "the", "potential", "to", "suppress", "AGE", "-", "mediated", "inflammatory", "response", "in", "THP-1", "cells", ".", "In", "the", "present", "study", ",", "we", "isolated", "catalpol", "from", "R.", "glutinosa", ",", "and", "examined", "whether", "it", "has", "anti", "-", "inflammatory", "effects", "on", "AGE", "-", "stimulated", "THP-1", "cells", ".", "Catalpol", "reduced", "the", "expression", "of", "pro", "-", "inflammatory", "mediates", ",", "such", "as", "monocyte", "chemotactic", "protein-1", "(", "MCP-1", ")", ",", "tumor", "necrosis", "factor", "-", "α", "(", "TNF", "-", "α", ")", ",", "inducible", "NO", "synthase", "(", "iNOS", ")", ",", "and", "receptor", "for", "AGE", "(", "RAGE", ")", ".", "Promoter", "and", "electromobility", "shift", "assays", "showed", "that", "transcriptional", "activation", "of", "NF", "-", "κB", "was", "significantly", "reduced", "by", "catalpol", "treatment", ",", "while", "AP-1", "was", "not", ".", "Catalpol", "also", "suppressed", "AGE", "-", "induced", "phosphorylation", "of", "mitogen", "activated", "protein", "(", "MAP", ")", "kinases", ",", "degradation", "of", "IκBα", "and", "the", "nuclear", "localization", "of", "NF", "-", "κB.", "Moreover", ",", "the", "production", "of", "intracellular", "reactive", "oxygen", "species", "(", "ROS", ")", "elicited", "by", "AGE", "was", "also", "suppressed", "by", "catalpol", "treatment", ",", "through", "dual", "action", "of", "reducing", "ROS", "itself", "and", "inhibiting", "NADPH", "oxidase", "activity", ".", "Our", "findings", "indicate", "that", "catalpol", "suppresses", "AGE", "-", "mediated", "inflammation", "by", "inhibiting", "ROS", "production", "and", "NF", "-", "κB", "activity", ".", "We", "suggest", "that", "catalpol", ",", "a", "major", "constituent", "of", "the", "fresh", "roots", "of", "R.", "glutinosa", ",", "contributes", "to", "the", "prevention", "of", "AGE", "-", "mediated", "diabetic", "complications", "." ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
Catalpol is a CHEMICAL, oxygen is a CHEMICAL, catalpol is a CHEMICAL, Catalpol is a CHEMICAL, monocyte chemotactic protein-1 is a GENE-Y, MCP-1 is a GENE-Y, tumor necrosis factor - α is a GENE-Y, TNF - α is a GENE-Y, inducible NO synthase is a GENE-Y, iNOS is a GENE-Y, receptor for AGE is a GENE-Y, RAGE is a GENE-Y, NF - κB is a GENE-N, catalpol is a CHEMICAL, AP-1 is a GENE-Y, Catalpol is a CHEMICAL, mitogen activated protein ( MAP ) kinases is a GENE-N, IκBα is a GENE-Y, oxygen is a CHEMICAL, catalpol is a CHEMICAL, NADPH oxidase is a GENE-N, catalpol is a CHEMICAL, NF - κB is a GENE-N, catalpol is a CHEMICAL	26385_task1	Sentence: Catalpol suppresses advanced glycation end-products-induced inflammatory responses through inhibition of reactive oxygen species in human monocytic THP-1 cells. Advanced glycation end-products (AGEs) play a pivotal role in the development of diabetic complications by inducing inflammation. We previously reported that the fresh roots of Rehmannia glutinosa Libosch., which have been used for the treatment of diabetes in traditional Korean medicine, also have the potential to suppress AGE-mediated inflammatory response in THP-1 cells. In the present study, we isolated catalpol from R. glutinosa, and examined whether it has anti-inflammatory effects on AGE-stimulated THP-1 cells. Catalpol reduced the expression of pro-inflammatory mediates, such as monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor-α (TNF-α), inducible NO synthase (iNOS), and receptor for AGE (RAGE). Promoter and electromobility shift assays showed that transcriptional activation of NF-κB was significantly reduced by catalpol treatment, while AP-1 was not. Catalpol also suppressed AGE-induced phosphorylation of mitogen activated protein (MAP) kinases, degradation of IκBα and the nuclear localization of NF-κB. Moreover, the production of intracellular reactive oxygen species (ROS) elicited by AGE was also suppressed by catalpol treatment, through dual action of reducing ROS itself and inhibiting NADPH oxidase activity. Our findings indicate that catalpol suppresses AGE-mediated inflammation by inhibiting ROS production and NF-κB activity. We suggest that catalpol, a major constituent of the fresh roots of R. glutinosa, contributes to the prevention of AGE-mediated diabetic complications. Instructions: please typing these entity words according to sentence: Catalpol, oxygen, catalpol, Catalpol, monocyte chemotactic protein-1, MCP-1, tumor necrosis factor - α, TNF - α, inducible NO synthase, iNOS, receptor for AGE, RAGE, NF - κB, catalpol, AP-1, Catalpol, mitogen activated protein ( MAP ) kinases, IκBα, oxygen, catalpol, NADPH oxidase, catalpol, NF - κB, catalpol Options: GENE-N, GENE-Y, CHEMICAL	[ "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Catalpol suppresses advanced glycation end-products-induced inflammatory responses through inhibition of reactive oxygen species in human monocytic THP-1 cells. Advanced glycation end-products (AGEs) play a pivotal role in the development of diabetic complications by inducing inflammation. We previously reported that the fresh roots of Rehmannia glutinosa Libosch., which have been used for the treatment of diabetes in traditional Korean medicine, also have the potential to suppress AGE-mediated inflammatory response in THP-1 cells. In the present study, we isolated catalpol from R. glutinosa, and examined whether it has anti-inflammatory effects on AGE-stimulated THP-1 cells. Catalpol reduced the expression of pro-inflammatory mediates, such as monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor-α (TNF-α), inducible NO synthase (iNOS), and receptor for AGE (RAGE). Promoter and electromobility shift assays showed that transcriptional activation of NF-κB was significantly reduced by catalpol treatment, while AP-1 was not. Catalpol also suppressed AGE-induced phosphorylation of mitogen activated protein (MAP) kinases, degradation of IκBα and the nuclear localization of NF-κB. Moreover, the production of intracellular reactive oxygen species (ROS) elicited by AGE was also suppressed by catalpol treatment, through dual action of reducing ROS itself and inhibiting NADPH oxidase activity. Our findings indicate that catalpol suppresses AGE-mediated inflammation by inhibiting ROS production and NF-κB activity. We suggest that catalpol, a major constituent of the fresh roots of R. glutinosa, contributes to the prevention of AGE-mediated diabetic complications.	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Catalpol, oxygen, catalpol, Catalpol, monocyte chemotactic protein-1, MCP-1, tumor necrosis factor - α, TNF - α, inducible NO synthase, iNOS, receptor for AGE, RAGE, NF - κB, catalpol, AP-1, Catalpol, mitogen activated protein ( MAP ) kinases, IκBα, oxygen, catalpol, NADPH oxidase, catalpol, NF - κB, catalpol	26385_task2	Sentence: Catalpol suppresses advanced glycation end-products-induced inflammatory responses through inhibition of reactive oxygen species in human monocytic THP-1 cells. Advanced glycation end-products (AGEs) play a pivotal role in the development of diabetic complications by inducing inflammation. We previously reported that the fresh roots of Rehmannia glutinosa Libosch., which have been used for the treatment of diabetes in traditional Korean medicine, also have the potential to suppress AGE-mediated inflammatory response in THP-1 cells. In the present study, we isolated catalpol from R. glutinosa, and examined whether it has anti-inflammatory effects on AGE-stimulated THP-1 cells. Catalpol reduced the expression of pro-inflammatory mediates, such as monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor-α (TNF-α), inducible NO synthase (iNOS), and receptor for AGE (RAGE). Promoter and electromobility shift assays showed that transcriptional activation of NF-κB was significantly reduced by catalpol treatment, while AP-1 was not. Catalpol also suppressed AGE-induced phosphorylation of mitogen activated protein (MAP) kinases, degradation of IκBα and the nuclear localization of NF-κB. Moreover, the production of intracellular reactive oxygen species (ROS) elicited by AGE was also suppressed by catalpol treatment, through dual action of reducing ROS itself and inhibiting NADPH oxidase activity. Our findings indicate that catalpol suppresses AGE-mediated inflammation by inhibiting ROS production and NF-κB activity. We suggest that catalpol, a major constituent of the fresh roots of R. glutinosa, contributes to the prevention of AGE-mediated diabetic complications. 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Advanced glycation end-products (AGEs) play a pivotal role in the development of diabetic complications by inducing inflammation. We previously reported that the fresh roots of Rehmannia glutinosa Libosch., which have been used for the treatment of diabetes in traditional Korean medicine, also have the potential to suppress AGE-mediated inflammatory response in THP-1 cells. In the present study, we isolated catalpol from R. glutinosa, and examined whether it has anti-inflammatory effects on AGE-stimulated THP-1 cells. Catalpol reduced the expression of pro-inflammatory mediates, such as monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor-α (TNF-α), inducible NO synthase (iNOS), and receptor for AGE (RAGE). Promoter and electromobility shift assays showed that transcriptional activation of NF-κB was significantly reduced by catalpol treatment, while AP-1 was not. Catalpol also suppressed AGE-induced phosphorylation of mitogen activated protein (MAP) kinases, degradation of IκBα and the nuclear localization of NF-κB. Moreover, the production of intracellular reactive oxygen species (ROS) elicited by AGE was also suppressed by catalpol treatment, through dual action of reducing ROS itself and inhibiting NADPH oxidase activity. Our findings indicate that catalpol suppresses AGE-mediated inflammation by inhibiting ROS production and NF-κB activity. We suggest that catalpol, a major constituent of the fresh roots of R. glutinosa, contributes to the prevention of AGE-mediated diabetic complications.	[ "Catalpol", "suppresses", "advanced", "glycation", "end", "-", "products", "-", "induced", "inflammatory", "responses", "through", "inhibition", "of", "reactive", "oxygen", "species", "in", "human", "monocytic", "THP-1", "cells", ".", "\n", "Advanced", "glycation", "end", "-", "products", "(", "AGEs", ")", "play", "a", "pivotal", "role", "in", "the", "development", "of", "diabetic", "complications", "by", "inducing", "inflammation", ".", "We", "previously", "reported", "that", "the", "fresh", "roots", "of", "Rehmannia", "glutinosa", "Libosch", ".", ",", "which", "have", "been", "used", "for", "the", "treatment", "of", "diabetes", "in", "traditional", "Korean", "medicine", ",", "also", "have", "the", "potential", "to", "suppress", "AGE", "-", "mediated", "inflammatory", "response", "in", "THP-1", "cells", ".", "In", "the", "present", "study", ",", "we", "isolated", "catalpol", "from", "R.", "glutinosa", ",", "and", "examined", "whether", "it", "has", "anti", "-", "inflammatory", "effects", "on", "AGE", "-", "stimulated", "THP-1", "cells", ".", "Catalpol", "reduced", "the", "expression", "of", "pro", "-", "inflammatory", "mediates", ",", "such", "as", "monocyte", "chemotactic", "protein-1", "(", "MCP-1", ")", ",", "tumor", "necrosis", "factor", "-", "α", "(", "TNF", "-", "α", ")", ",", "inducible", "NO", "synthase", "(", "iNOS", ")", ",", "and", "receptor", "for", "AGE", "(", "RAGE", ")", ".", "Promoter", "and", "electromobility", "shift", "assays", "showed", "that", "transcriptional", "activation", "of", "NF", "-", "κB", "was", "significantly", "reduced", "by", "catalpol", "treatment", ",", "while", "AP-1", "was", "not", ".", "Catalpol", "also", "suppressed", "AGE", "-", "induced", "phosphorylation", "of", "mitogen", "activated", "protein", "(", "MAP", ")", "kinases", ",", "degradation", "of", "IκBα", "and", "the", "nuclear", "localization", "of", "NF", "-", "κB.", "Moreover", ",", "the", "production", "of", "intracellular", "reactive", "oxygen", "species", "(", "ROS", ")", "elicited", "by", "AGE", "was", "also", "suppressed", "by", "catalpol", "treatment", ",", "through", "dual", "action", "of", "reducing", "ROS", "itself", "and", "inhibiting", "NADPH", "oxidase", "activity", ".", "Our", "findings", "indicate", "that", "catalpol", "suppresses", "AGE", "-", "mediated", "inflammation", "by", "inhibiting", "ROS", "production", "and", "NF", "-", "κB", "activity", ".", "We", "suggest", "that", "catalpol", ",", "a", "major", "constituent", "of", "the", "fresh", "roots", "of", "R.", "glutinosa", ",", "contributes", "to", "the", "prevention", "of", "AGE", "-", "mediated", "diabetic", "complications", "." ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
Transient lower esophageal sphincter relaxations ( TLESRs ) is a Outcome_Physical, loxiglumide is a Intervention_Pharmacological, Eight is a Participant_Sample-size, healthy subjects underwent esophageal manometry using a 10-lumen sleeve assembly during placebo or loxiglumide ( 10 mg / kg / h ) in is a Participant_Condition, Basal lower esophageal pressure ( LESP ) is a Outcome_Physical, swallow - induced relaxation is a Outcome_Physical, number of common cavities is a Outcome_Physical	92761_task0	Sentence: Involvement of cholecystokininA receptors in transient lower esophageal sphincter relaxations triggered by gastric distension . OBJECTIVE Transient lower esophageal sphincter relaxations ( TLESRs ) are the main mechanism underlying gastroesophageal reflux . In the present study we evaluated the effect of loxiglumide , a specific cholecystokininA ( CCKA ) -receptor antagonist , on the occurrence of TLESRs evoked by gastric distension . METHODS Eight healthy subjects underwent esophageal manometry using a 10-lumen sleeve assembly during placebo or loxiglumide ( 10 mg/kg/h ) in a randomized double-blind order . Gastric distension was induced by inflation of 400 ml of air . RESULTS Basal lower esophageal pressure ( LESP ) and swallow-induced relaxation were not affected by loxiglumide . Loxiglumide significantly reduced the number of TLESRs , from 11.5 ( 5.8-18.3 ) to 6.0 ( 3.3-14.3 ) during the total recording period of 1 h , and from 5.5 ( 4.25-7.5 ) to 2.0 ( 0.5-6.8 ) during the first 15 min . The number of common cavities was significantly decreased by loxiglumide , from 8.0 ( 4.0-20.0 ) to 5.0 ( 2.0-7.8 ) . TLESRs represented the main mechanism ( 60 % during placebo , 74 % during loxiglumide ) underlying common cavities , followed by swallow-induced relaxation . CONCLUSIONS Loxiglumide significantly reduces the number of TLESRs triggered by gastric distension without interfering with swallow-related relaxation of the lower esophageal sphincter , suggesting the involvement of CCKA receptors in the reflex pathway mediating TLESRs . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Outcome_Physical, Participant_Condition, Participant_Sample-size	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Involvement of cholecystokininA receptors in transient lower esophageal sphincter relaxations triggered by gastric distension . OBJECTIVE Transient lower esophageal sphincter relaxations ( TLESRs ) are the main mechanism underlying gastroesophageal reflux . In the present study we evaluated the effect of loxiglumide , a specific cholecystokininA ( CCKA ) -receptor antagonist , on the occurrence of TLESRs evoked by gastric distension . METHODS Eight healthy subjects underwent esophageal manometry using a 10-lumen sleeve assembly during placebo or loxiglumide ( 10 mg/kg/h ) in a randomized double-blind order . Gastric distension was induced by inflation of 400 ml of air . RESULTS Basal lower esophageal pressure ( LESP ) and swallow-induced relaxation were not affected by loxiglumide . Loxiglumide significantly reduced the number of TLESRs , from 11.5 ( 5.8-18.3 ) to 6.0 ( 3.3-14.3 ) during the total recording period of 1 h , and from 5.5 ( 4.25-7.5 ) to 2.0 ( 0.5-6.8 ) during the first 15 min . The number of common cavities was significantly decreased by loxiglumide , from 8.0 ( 4.0-20.0 ) to 5.0 ( 2.0-7.8 ) . TLESRs represented the main mechanism ( 60 % during placebo , 74 % during loxiglumide ) underlying common cavities , followed by swallow-induced relaxation . CONCLUSIONS Loxiglumide significantly reduces the number of TLESRs triggered by gastric distension without interfering with swallow-related relaxation of the lower esophageal sphincter , suggesting the involvement of CCKA receptors in the reflex pathway mediating TLESRs .	[ "Involvement", "of", "cholecystokininA", "receptors", "in", "transient", "lower", "esophageal", "sphincter", "relaxations", "triggered", "by", "gastric", "distension", ".", "OBJECTIVE", "Transient", "lower", "esophageal", "sphincter", "relaxations", "(", "TLESRs", ")", "are", "the", "main", "mechanism", "underlying", "gastroesophageal", "reflux", ".", "In", "the", "present", "study", "we", "evaluated", "the", "effect", "of", "loxiglumide", ",", "a", "specific", "cholecystokininA", "(", "CCKA", ")", "-receptor", "antagonist", ",", "on", "the", "occurrence", "of", "TLESRs", "evoked", "by", "gastric", "distension", ".", "METHODS", "Eight", "healthy", "subjects", "underwent", "esophageal", "manometry", "using", "a", "10-lumen", "sleeve", "assembly", "during", "placebo", "or", "loxiglumide", "(", "10", "mg", "/", "kg", "/", "h", ")", "in", "a", "randomized", "double", "-", "blind", "order", ".", "Gastric", "distension", "was", "induced", "by", "inflation", "of", "400", "ml", "of", "air", ".", "RESULTS", "Basal", "lower", "esophageal", "pressure", "(", "LESP", ")", "and", "swallow", "-", "induced", "relaxation", "were", "not", "affected", "by", "loxiglumide", ".", "Loxiglumide", "significantly", "reduced", "the", "number", "of", "TLESRs", ",", "from", "11.5", "(", "5.8", "-", "18.3", ")", "to", "6.0", "(", "3.3", "-", "14.3", ")", "during", "the", "total", "recording", "period", "of", "1", "h", ",", "and", "from", "5.5", "(", "4.25", "-", "7.5", ")", "to", "2.0", "(", "0.5", "-", "6.8", ")", "during", "the", "first", "15", "min", ".", "The", "number", "of", "common", "cavities", "was", "significantly", "decreased", "by", "loxiglumide", ",", "from", "8.0", "(", "4.0", "-", "20.0", ")", "to", "5.0", "(", "2.0", "-", "7.8", ")", ".", "TLESRs", "represented", "the", "main", "mechanism", "(", "60", "%", "during", "placebo", ",", "74", "%", "during", "loxiglumide", ")", "underlying", "common", "cavities", ",", "followed", "by", "swallow", "-", "induced", "relaxation", ".", "CONCLUSIONS", "Loxiglumide", "significantly", "reduces", "the", "number", "of", "TLESRs", "triggered", "by", "gastric", "distension", "without", "interfering", "with", "swallow", "-", "related", "relaxation", "of", "the", "lower", "esophageal", "sphincter", ",", "suggesting", "the", "involvement", "of", "CCKA", "receptors", "in", "the", "reflex", "pathway", "mediating", "TLESRs", "." ]	[ "Participant_Condition", "Outcome_Physical", "Intervention_Physical", "Intervention_Pharmacological", "Participant_Sample-size" ]
Transient lower esophageal sphincter relaxations ( TLESRs ) is a Outcome_Physical, loxiglumide is a Intervention_Pharmacological, Eight is a Participant_Sample-size, healthy subjects underwent esophageal manometry using a 10-lumen sleeve assembly during placebo or loxiglumide ( 10 mg / kg / h ) in is a Participant_Condition, Basal lower esophageal pressure ( LESP ) is a Outcome_Physical, swallow - induced relaxation is a Outcome_Physical, number of common cavities is a Outcome_Physical	92761_task1	Sentence: Involvement of cholecystokininA receptors in transient lower esophageal sphincter relaxations triggered by gastric distension . OBJECTIVE Transient lower esophageal sphincter relaxations ( TLESRs ) are the main mechanism underlying gastroesophageal reflux . In the present study we evaluated the effect of loxiglumide , a specific cholecystokininA ( CCKA ) -receptor antagonist , on the occurrence of TLESRs evoked by gastric distension . METHODS Eight healthy subjects underwent esophageal manometry using a 10-lumen sleeve assembly during placebo or loxiglumide ( 10 mg/kg/h ) in a randomized double-blind order . Gastric distension was induced by inflation of 400 ml of air . RESULTS Basal lower esophageal pressure ( LESP ) and swallow-induced relaxation were not affected by loxiglumide . Loxiglumide significantly reduced the number of TLESRs , from 11.5 ( 5.8-18.3 ) to 6.0 ( 3.3-14.3 ) during the total recording period of 1 h , and from 5.5 ( 4.25-7.5 ) to 2.0 ( 0.5-6.8 ) during the first 15 min . The number of common cavities was significantly decreased by loxiglumide , from 8.0 ( 4.0-20.0 ) to 5.0 ( 2.0-7.8 ) . TLESRs represented the main mechanism ( 60 % during placebo , 74 % during loxiglumide ) underlying common cavities , followed by swallow-induced relaxation . CONCLUSIONS Loxiglumide significantly reduces the number of TLESRs triggered by gastric distension without interfering with swallow-related relaxation of the lower esophageal sphincter , suggesting the involvement of CCKA receptors in the reflex pathway mediating TLESRs . Instructions: please typing these entity words according to sentence: Transient lower esophageal sphincter relaxations ( TLESRs ), loxiglumide, Eight, healthy subjects underwent esophageal manometry using a 10-lumen sleeve assembly during placebo or loxiglumide ( 10 mg / kg / h ) in, Basal lower esophageal pressure ( LESP ), swallow - induced relaxation, number of common cavities Options: Intervention_Pharmacological, Outcome_Physical, Participant_Condition, Participant_Sample-size	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Involvement of cholecystokininA receptors in transient lower esophageal sphincter relaxations triggered by gastric distension . OBJECTIVE Transient lower esophageal sphincter relaxations ( TLESRs ) are the main mechanism underlying gastroesophageal reflux . In the present study we evaluated the effect of loxiglumide , a specific cholecystokininA ( CCKA ) -receptor antagonist , on the occurrence of TLESRs evoked by gastric distension . METHODS Eight healthy subjects underwent esophageal manometry using a 10-lumen sleeve assembly during placebo or loxiglumide ( 10 mg/kg/h ) in a randomized double-blind order . Gastric distension was induced by inflation of 400 ml of air . RESULTS Basal lower esophageal pressure ( LESP ) and swallow-induced relaxation were not affected by loxiglumide . Loxiglumide significantly reduced the number of TLESRs , from 11.5 ( 5.8-18.3 ) to 6.0 ( 3.3-14.3 ) during the total recording period of 1 h , and from 5.5 ( 4.25-7.5 ) to 2.0 ( 0.5-6.8 ) during the first 15 min . The number of common cavities was significantly decreased by loxiglumide , from 8.0 ( 4.0-20.0 ) to 5.0 ( 2.0-7.8 ) . TLESRs represented the main mechanism ( 60 % during placebo , 74 % during loxiglumide ) underlying common cavities , followed by swallow-induced relaxation . CONCLUSIONS Loxiglumide significantly reduces the number of TLESRs triggered by gastric distension without interfering with swallow-related relaxation of the lower esophageal sphincter , suggesting the involvement of CCKA receptors in the reflex pathway mediating TLESRs .	[ "Involvement", "of", "cholecystokininA", "receptors", "in", "transient", "lower", "esophageal", "sphincter", "relaxations", "triggered", "by", "gastric", "distension", ".", "OBJECTIVE", "Transient", "lower", "esophageal", "sphincter", "relaxations", "(", "TLESRs", ")", "are", "the", "main", "mechanism", "underlying", "gastroesophageal", "reflux", ".", "In", "the", "present", "study", "we", "evaluated", "the", "effect", "of", "loxiglumide", ",", "a", "specific", "cholecystokininA", "(", "CCKA", ")", "-receptor", "antagonist", ",", "on", "the", "occurrence", "of", "TLESRs", "evoked", "by", "gastric", "distension", ".", "METHODS", "Eight", "healthy", "subjects", "underwent", "esophageal", "manometry", "using", "a", "10-lumen", "sleeve", "assembly", "during", "placebo", "or", "loxiglumide", "(", "10", "mg", "/", "kg", "/", "h", ")", "in", "a", "randomized", "double", "-", "blind", "order", ".", "Gastric", "distension", "was", "induced", "by", "inflation", "of", "400", "ml", "of", "air", ".", "RESULTS", "Basal", "lower", "esophageal", "pressure", "(", "LESP", ")", "and", "swallow", "-", "induced", "relaxation", "were", "not", "affected", "by", "loxiglumide", ".", "Loxiglumide", "significantly", "reduced", "the", "number", "of", "TLESRs", ",", "from", "11.5", "(", "5.8", "-", "18.3", ")", "to", "6.0", "(", "3.3", "-", "14.3", ")", "during", "the", "total", "recording", "period", "of", "1", "h", ",", "and", "from", "5.5", "(", "4.25", "-", "7.5", ")", "to", "2.0", "(", "0.5", "-", "6.8", ")", "during", "the", "first", "15", "min", ".", "The", "number", "of", "common", "cavities", "was", "significantly", "decreased", "by", "loxiglumide", ",", "from", "8.0", "(", "4.0", "-", "20.0", ")", "to", "5.0", "(", "2.0", "-", "7.8", ")", ".", "TLESRs", "represented", "the", "main", "mechanism", "(", "60", "%", "during", "placebo", ",", "74", "%", "during", "loxiglumide", ")", "underlying", "common", "cavities", ",", "followed", "by", "swallow", "-", "induced", "relaxation", ".", "CONCLUSIONS", "Loxiglumide", "significantly", "reduces", "the", "number", "of", "TLESRs", "triggered", "by", "gastric", "distension", "without", "interfering", "with", "swallow", "-", "related", "relaxation", "of", "the", "lower", "esophageal", "sphincter", ",", "suggesting", "the", "involvement", "of", "CCKA", "receptors", "in", "the", "reflex", "pathway", "mediating", "TLESRs", "." ]	[ "Participant_Condition", "Outcome_Physical", "Intervention_Physical", "Intervention_Pharmacological", "Participant_Sample-size" ]
Transient lower esophageal sphincter relaxations ( TLESRs ), loxiglumide, Eight, healthy subjects underwent esophageal manometry using a 10-lumen sleeve assembly during placebo or loxiglumide ( 10 mg / kg / h ) in, Basal lower esophageal pressure ( LESP ), swallow - induced relaxation, number of common cavities	92761_task2	Sentence: Involvement of cholecystokininA receptors in transient lower esophageal sphincter relaxations triggered by gastric distension . OBJECTIVE Transient lower esophageal sphincter relaxations ( TLESRs ) are the main mechanism underlying gastroesophageal reflux . In the present study we evaluated the effect of loxiglumide , a specific cholecystokininA ( CCKA ) -receptor antagonist , on the occurrence of TLESRs evoked by gastric distension . METHODS Eight healthy subjects underwent esophageal manometry using a 10-lumen sleeve assembly during placebo or loxiglumide ( 10 mg/kg/h ) in a randomized double-blind order . Gastric distension was induced by inflation of 400 ml of air . RESULTS Basal lower esophageal pressure ( LESP ) and swallow-induced relaxation were not affected by loxiglumide . Loxiglumide significantly reduced the number of TLESRs , from 11.5 ( 5.8-18.3 ) to 6.0 ( 3.3-14.3 ) during the total recording period of 1 h , and from 5.5 ( 4.25-7.5 ) to 2.0 ( 0.5-6.8 ) during the first 15 min . The number of common cavities was significantly decreased by loxiglumide , from 8.0 ( 4.0-20.0 ) to 5.0 ( 2.0-7.8 ) . TLESRs represented the main mechanism ( 60 % during placebo , 74 % during loxiglumide ) underlying common cavities , followed by swallow-induced relaxation . CONCLUSIONS Loxiglumide significantly reduces the number of TLESRs triggered by gastric distension without interfering with swallow-related relaxation of the lower esophageal sphincter , suggesting the involvement of CCKA receptors in the reflex pathway mediating TLESRs . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Involvement of cholecystokininA receptors in transient lower esophageal sphincter relaxations triggered by gastric distension . OBJECTIVE Transient lower esophageal sphincter relaxations ( TLESRs ) are the main mechanism underlying gastroesophageal reflux . In the present study we evaluated the effect of loxiglumide , a specific cholecystokininA ( CCKA ) -receptor antagonist , on the occurrence of TLESRs evoked by gastric distension . METHODS Eight healthy subjects underwent esophageal manometry using a 10-lumen sleeve assembly during placebo or loxiglumide ( 10 mg/kg/h ) in a randomized double-blind order . Gastric distension was induced by inflation of 400 ml of air . RESULTS Basal lower esophageal pressure ( LESP ) and swallow-induced relaxation were not affected by loxiglumide . Loxiglumide significantly reduced the number of TLESRs , from 11.5 ( 5.8-18.3 ) to 6.0 ( 3.3-14.3 ) during the total recording period of 1 h , and from 5.5 ( 4.25-7.5 ) to 2.0 ( 0.5-6.8 ) during the first 15 min . The number of common cavities was significantly decreased by loxiglumide , from 8.0 ( 4.0-20.0 ) to 5.0 ( 2.0-7.8 ) . TLESRs represented the main mechanism ( 60 % during placebo , 74 % during loxiglumide ) underlying common cavities , followed by swallow-induced relaxation . CONCLUSIONS Loxiglumide significantly reduces the number of TLESRs triggered by gastric distension without interfering with swallow-related relaxation of the lower esophageal sphincter , suggesting the involvement of CCKA receptors in the reflex pathway mediating TLESRs .	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ICSI is an umlsterm, maennliche is an umlsterm, Methode is an umlsterm, ICSI is an umlsterm, Patienten is an umlsterm, Azoospermie is an umlsterm, Schwangerschaften is an umlsterm, Spermatogenesestoerungen is an umlsterm, Spermatozoen is an umlsterm, Hoden is an umlsterm, Injektion is an umlsterm, Spermatiden is an umlsterm, Spermatogenese is an umlsterm, Reproduktion is an umlsterm	DerUrologeA.90380575.ger.abstr_task0	Sentence: Mit der Einfuehrung der intrazytoplasmatischen Spermatozoeninjektion ( ICSI 1992 ) ist die schwere maennliche Subfertilitaet behandelbar geworden . Darueberhinaus konnte die Methode der ICSI auch bei Patienten mit Azoospermie durch die Anwendung der testikulaeren Spermatozoenextraktion ( TESE ) Schwangerschaften induzieren . Jedoch schwerste Spermatogenesestoerungen mit Reifungsarrest erfordern in Abwesenheit von reifen testikulaeren Spermatozoen im Hoden die intraooplasmatische Injektion von runden oder elongierten Spermatiden . Unter Zugrundelegung der Mechanismen der Spermatogenese und der genetischen Implikationen ihrer Fehlsteuerungen werden hier die Grenzen einer sinnvollen und erfolgreichen assistierten Reproduktion evident . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Mit der Einfuehrung der intrazytoplasmatischen Spermatozoeninjektion ( ICSI 1992 ) ist die schwere maennliche Subfertilitaet behandelbar geworden . Darueberhinaus konnte die Methode der ICSI auch bei Patienten mit Azoospermie durch die Anwendung der testikulaeren Spermatozoenextraktion ( TESE ) Schwangerschaften induzieren . Jedoch schwerste Spermatogenesestoerungen mit Reifungsarrest erfordern in Abwesenheit von reifen testikulaeren Spermatozoen im Hoden die intraooplasmatische Injektion von runden oder elongierten Spermatiden . Unter Zugrundelegung der Mechanismen der Spermatogenese und der genetischen Implikationen ihrer Fehlsteuerungen werden hier die Grenzen einer sinnvollen und erfolgreichen assistierten Reproduktion evident .	[ "Mit", "der", "Einfuehrung", "der", "intrazytoplasmatischen", "Spermatozoeninjektion", "(", "ICSI", "1992", ")", "ist", "die", "schwere", "maennliche", "Subfertilitaet", "behandelbar", "geworden", ".", "Darueberhinaus", "konnte", "die", "Methode", "der", "ICSI", "auch", "bei", "Patienten", "mit", "Azoospermie", "durch", "die", "Anwendung", "der", "testikulaeren", "Spermatozoenextraktion", "(", "TESE", ")", "Schwangerschaften", "induzieren", ".", "Jedoch", "schwerste", "Spermatogenesestoerungen", "mit", "Reifungsarrest", "erfordern", "in", "Abwesenheit", "von", "reifen", "testikulaeren", "Spermatozoen", "im", "Hoden", "die", "intraooplasmatische", "Injektion", "von", "runden", "oder", "elongierten", "Spermatiden", ".", "Unter", "Zugrundelegung", "der", "Mechanismen", "der", "Spermatogenese", "und", "der", "genetischen", "Implikationen", "ihrer", "Fehlsteuerungen", "werden", "hier", "die", "Grenzen", "einer", "sinnvollen", "und", "erfolgreichen", "assistierten", "Reproduktion", "evident", "." ]	[ "umlsterm" ]
ICSI is an umlsterm, maennliche is an umlsterm, Methode is an umlsterm, ICSI is an umlsterm, Patienten is an umlsterm, Azoospermie is an umlsterm, Schwangerschaften is an umlsterm, Spermatogenesestoerungen is an umlsterm, Spermatozoen is an umlsterm, Hoden is an umlsterm, Injektion is an umlsterm, Spermatiden is an umlsterm, Spermatogenese is an umlsterm, Reproduktion is an umlsterm	DerUrologeA.90380575.ger.abstr_task1	Sentence: Mit der Einfuehrung der intrazytoplasmatischen Spermatozoeninjektion ( ICSI 1992 ) ist die schwere maennliche Subfertilitaet behandelbar geworden . Darueberhinaus konnte die Methode der ICSI auch bei Patienten mit Azoospermie durch die Anwendung der testikulaeren Spermatozoenextraktion ( TESE ) Schwangerschaften induzieren . Jedoch schwerste Spermatogenesestoerungen mit Reifungsarrest erfordern in Abwesenheit von reifen testikulaeren Spermatozoen im Hoden die intraooplasmatische Injektion von runden oder elongierten Spermatiden . Unter Zugrundelegung der Mechanismen der Spermatogenese und der genetischen Implikationen ihrer Fehlsteuerungen werden hier die Grenzen einer sinnvollen und erfolgreichen assistierten Reproduktion evident . Instructions: please typing these entity words according to sentence: ICSI, maennliche, Methode, ICSI, Patienten, Azoospermie, Schwangerschaften, Spermatogenesestoerungen, Spermatozoen, Hoden, Injektion, Spermatiden, Spermatogenese, Reproduktion Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Mit der Einfuehrung der intrazytoplasmatischen Spermatozoeninjektion ( ICSI 1992 ) ist die schwere maennliche Subfertilitaet behandelbar geworden . Darueberhinaus konnte die Methode der ICSI auch bei Patienten mit Azoospermie durch die Anwendung der testikulaeren Spermatozoenextraktion ( TESE ) Schwangerschaften induzieren . Jedoch schwerste Spermatogenesestoerungen mit Reifungsarrest erfordern in Abwesenheit von reifen testikulaeren Spermatozoen im Hoden die intraooplasmatische Injektion von runden oder elongierten Spermatiden . Unter Zugrundelegung der Mechanismen der Spermatogenese und der genetischen Implikationen ihrer Fehlsteuerungen werden hier die Grenzen einer sinnvollen und erfolgreichen assistierten Reproduktion evident .	[ "Mit", "der", "Einfuehrung", "der", "intrazytoplasmatischen", "Spermatozoeninjektion", "(", "ICSI", "1992", ")", "ist", "die", "schwere", "maennliche", "Subfertilitaet", "behandelbar", "geworden", ".", "Darueberhinaus", "konnte", "die", "Methode", "der", "ICSI", "auch", "bei", "Patienten", "mit", "Azoospermie", "durch", "die", "Anwendung", "der", "testikulaeren", "Spermatozoenextraktion", "(", "TESE", ")", "Schwangerschaften", "induzieren", ".", "Jedoch", "schwerste", "Spermatogenesestoerungen", "mit", "Reifungsarrest", "erfordern", "in", "Abwesenheit", "von", "reifen", "testikulaeren", "Spermatozoen", "im", "Hoden", "die", "intraooplasmatische", "Injektion", "von", "runden", "oder", "elongierten", "Spermatiden", ".", "Unter", "Zugrundelegung", "der", "Mechanismen", "der", "Spermatogenese", "und", "der", "genetischen", "Implikationen", "ihrer", "Fehlsteuerungen", "werden", "hier", "die", "Grenzen", "einer", "sinnvollen", "und", "erfolgreichen", "assistierten", "Reproduktion", "evident", "." ]	[ "umlsterm" ]
ICSI, maennliche, Methode, ICSI, Patienten, Azoospermie, Schwangerschaften, Spermatogenesestoerungen, Spermatozoen, Hoden, Injektion, Spermatiden, Spermatogenese, Reproduktion	DerUrologeA.90380575.ger.abstr_task2	Sentence: Mit der Einfuehrung der intrazytoplasmatischen Spermatozoeninjektion ( ICSI 1992 ) ist die schwere maennliche Subfertilitaet behandelbar geworden . Darueberhinaus konnte die Methode der ICSI auch bei Patienten mit Azoospermie durch die Anwendung der testikulaeren Spermatozoenextraktion ( TESE ) Schwangerschaften induzieren . Jedoch schwerste Spermatogenesestoerungen mit Reifungsarrest erfordern in Abwesenheit von reifen testikulaeren Spermatozoen im Hoden die intraooplasmatische Injektion von runden oder elongierten Spermatiden . Unter Zugrundelegung der Mechanismen der Spermatogenese und der genetischen Implikationen ihrer Fehlsteuerungen werden hier die Grenzen einer sinnvollen und erfolgreichen assistierten Reproduktion evident . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Mit der Einfuehrung der intrazytoplasmatischen Spermatozoeninjektion ( ICSI 1992 ) ist die schwere maennliche Subfertilitaet behandelbar geworden . Darueberhinaus konnte die Methode der ICSI auch bei Patienten mit Azoospermie durch die Anwendung der testikulaeren Spermatozoenextraktion ( TESE ) Schwangerschaften induzieren . Jedoch schwerste Spermatogenesestoerungen mit Reifungsarrest erfordern in Abwesenheit von reifen testikulaeren Spermatozoen im Hoden die intraooplasmatische Injektion von runden oder elongierten Spermatiden . Unter Zugrundelegung der Mechanismen der Spermatogenese und der genetischen Implikationen ihrer Fehlsteuerungen werden hier die Grenzen einer sinnvollen und erfolgreichen assistierten Reproduktion evident .	[ "Mit", "der", "Einfuehrung", "der", "intrazytoplasmatischen", "Spermatozoeninjektion", "(", "ICSI", "1992", ")", "ist", "die", "schwere", "maennliche", "Subfertilitaet", "behandelbar", "geworden", ".", "Darueberhinaus", "konnte", "die", "Methode", "der", "ICSI", "auch", "bei", "Patienten", "mit", "Azoospermie", "durch", "die", "Anwendung", "der", "testikulaeren", "Spermatozoenextraktion", "(", "TESE", ")", "Schwangerschaften", "induzieren", ".", "Jedoch", "schwerste", "Spermatogenesestoerungen", "mit", "Reifungsarrest", "erfordern", "in", "Abwesenheit", "von", "reifen", "testikulaeren", "Spermatozoen", "im", "Hoden", "die", "intraooplasmatische", "Injektion", "von", "runden", "oder", "elongierten", "Spermatiden", ".", "Unter", "Zugrundelegung", "der", "Mechanismen", "der", "Spermatogenese", "und", "der", "genetischen", "Implikationen", "ihrer", "Fehlsteuerungen", "werden", "hier", "die", "Grenzen", "einer", "sinnvollen", "und", "erfolgreichen", "assistierten", "Reproduktion", "evident", "." ]	[ "umlsterm" ]
endometrial cancer is a Participant_Condition, 467 is a Participant_Sample-size, women is a Participant_Sex, type 1 or 2 endometrial cancer is a Participant_Condition, tumor is a Participant_Condition, type 1 endometrial cancer is a Participant_Condition, overall endometrial cancer risk is a Outcome_Physical, 9708/9905 , miRNA expression is a Outcome_Other, status is a Outcome_Other, Overall survival rates is a Outcome_Mortality, variant and wild - type alleles is a Participant_Condition	65129_task0	Sentence: The KRAS-variant and miRNA expression in RTOG endometrial cancer clinical trials 9708 and 9905 . OBJECTIVE To explore the association of a functional germline variant in the 3'-UTR of KRAS with endometrial cancer risk , as well as the association of microRNA ( miRNA ) signatures and the KRAS-variant with clinical characteristics and survival outcomes in two prospective RTOG endometrial cancer trials . METHODS/MATERIALS The association of the KRAS-variant with endometrial cancer risk was evaluated by case-control analysis of 467 women with type 1 or 2 endometrial cancer and 582 age-matched controls . miRNA and DNA were isolated for expression profiling and genotyping from tumor specimens of 46 women with type 1 endometrial cancer enrolled in RTOG trials 9708 and 9905. miRNA expression levels and KRAS-variant genotype were correlated with patient and tumor characteristics , and survival outcomes were evaluated by variant allele type . RESULTS The KRAS-variant was not significantly associated with overall endometrial cancer risk ( 14 % controls and 17 % type 1 cancers ) , although was enriched in type 2 endometrial cancers ( 24 % , p = 0.2 ) . In the combined analysis of RTOG 9708/9905 , miRNA expression differed by age , presence of lymphovascular invasion and KRAS-variant status . Overall survival rates at 3 years for patients with the variant and wild-type alleles were 100 % and 77 % ( HR 0.3 , p = 0.24 ) , respectively , favoring the variant . CONCLUSIONS The KRAS-variant may be a genetic marker of risk for type 2 endometrial cancers . In addition , tumor miRNA expression appears to be associated with patient age , lymphovascular invasion and the KRAS-variant , supporting the hypothesis that altered tumor biology can be measured by miRNA expression , and that the KRAS-variant likely impacts endometrial tumor biology . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Participant_Sex, Participant_Condition, Outcome_Mortality, Outcome_Physical, Participant_Sample-size, Outcome_Other	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "B-Participant_Sex", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The KRAS-variant and miRNA expression in RTOG endometrial cancer clinical trials 9708 and 9905 . OBJECTIVE To explore the association of a functional germline variant in the 3'-UTR of KRAS with endometrial cancer risk , as well as the association of microRNA ( miRNA ) signatures and the KRAS-variant with clinical characteristics and survival outcomes in two prospective RTOG endometrial cancer trials . METHODS/MATERIALS The association of the KRAS-variant with endometrial cancer risk was evaluated by case-control analysis of 467 women with type 1 or 2 endometrial cancer and 582 age-matched controls . miRNA and DNA were isolated for expression profiling and genotyping from tumor specimens of 46 women with type 1 endometrial cancer enrolled in RTOG trials 9708 and 9905. miRNA expression levels and KRAS-variant genotype were correlated with patient and tumor characteristics , and survival outcomes were evaluated by variant allele type . RESULTS The KRAS-variant was not significantly associated with overall endometrial cancer risk ( 14 % controls and 17 % type 1 cancers ) , although was enriched in type 2 endometrial cancers ( 24 % , p = 0.2 ) . In the combined analysis of RTOG 9708/9905 , miRNA expression differed by age , presence of lymphovascular invasion and KRAS-variant status . Overall survival rates at 3 years for patients with the variant and wild-type alleles were 100 % and 77 % ( HR 0.3 , p = 0.24 ) , respectively , favoring the variant . CONCLUSIONS The KRAS-variant may be a genetic marker of risk for type 2 endometrial cancers . In addition , tumor miRNA expression appears to be associated with patient age , lymphovascular invasion and the KRAS-variant , supporting the hypothesis that altered tumor biology can be measured by miRNA expression , and that the KRAS-variant likely impacts endometrial tumor biology .	[ "The", "KRAS", "-", "variant", "and", "miRNA", "expression", "in", "RTOG", "endometrial", "cancer", "clinical", "trials", "9708", "and", "9905", ".", "OBJECTIVE", "To", "explore", "the", "association", "of", "a", "functional", "germline", "variant", "in", "the", "3'-UTR", "of", "KRAS", "with", "endometrial", "cancer", "risk", ",", "as", "well", "as", "the", "association", "of", "microRNA", "(", "miRNA", ")", "signatures", "and", "the", "KRAS", "-", "variant", "with", "clinical", "characteristics", "and", "survival", "outcomes", "in", "two", "prospective", "RTOG", "endometrial", "cancer", "trials", ".", "METHODS", "/", "MATERIALS", "The", "association", "of", "the", "KRAS", "-", "variant", "with", "endometrial", "cancer", "risk", "was", "evaluated", "by", "case", "-", "control", "analysis", "of", "467", "women", "with", "type", "1", "or", "2", "endometrial", "cancer", "and", "582", "age", "-", "matched", "controls", ".", "miRNA", "and", "DNA", "were", "isolated", "for", "expression", "profiling", "and", "genotyping", "from", "tumor", "specimens", "of", "46", "women", "with", "type", "1", "endometrial", "cancer", "enrolled", "in", "RTOG", "trials", "9708", "and", "9905", ".", "miRNA", "expression", "levels", "and", "KRAS", "-", "variant", "genotype", "were", "correlated", "with", "patient", "and", "tumor", "characteristics", ",", "and", "survival", "outcomes", "were", "evaluated", "by", "variant", "allele", "type", ".", "RESULTS", "The", "KRAS", "-", "variant", "was", "not", "significantly", "associated", "with", "overall", "endometrial", "cancer", "risk", "(", "14", "%", "controls", "and", "17", "%", "type", "1", "cancers", ")", ",", "although", "was", "enriched", "in", "type", "2", "endometrial", "cancers", "(", "24", "%", ",", "p", "=", "0.2", ")", ".", "In", "the", "combined", "analysis", "of", "RTOG", "9708/9905", ",", "miRNA", "expression", "differed", "by", "age", ",", "presence", "of", "lymphovascular", "invasion", "and", "KRAS", "-", "variant", "status", ".", "Overall", "survival", "rates", "at", "3", "years", "for", "patients", "with", "the", "variant", "and", "wild", "-", "type", "alleles", "were", "100", "%", "and", "77", "%", "(", "HR", "0.3", ",", "p", "=", "0.24", ")", ",", "respectively", ",", "favoring", "the", "variant", ".", "CONCLUSIONS", "The", "KRAS", "-", "variant", "may", "be", "a", "genetic", "marker", "of", "risk", "for", "type", "2", "endometrial", "cancers", ".", "In", "addition", ",", "tumor", "miRNA", "expression", "appears", "to", "be", "associated", "with", "patient", "age", ",", "lymphovascular", "invasion", "and", "the", "KRAS", "-", "variant", ",", "supporting", "the", "hypothesis", "that", "altered", "tumor", "biology", "can", "be", "measured", "by", "miRNA", "expression", ",", "and", "that", "the", "KRAS", "-", "variant", "likely", "impacts", "endometrial", "tumor", "biology", "." ]	[ "Outcome_Physical", "Participant_Condition", "Outcome_Other", "Outcome_Mortality", "Participant_Sex", "Participant_Sample-size" ]
endometrial cancer is a Participant_Condition, 467 is a Participant_Sample-size, women is a Participant_Sex, type 1 or 2 endometrial cancer is a Participant_Condition, tumor is a Participant_Condition, type 1 endometrial cancer is a Participant_Condition, overall endometrial cancer risk is a Outcome_Physical, 9708/9905 , miRNA expression is a Outcome_Other, status is a Outcome_Other, Overall survival rates is a Outcome_Mortality, variant and wild - type alleles is a Participant_Condition	65129_task1	Sentence: The KRAS-variant and miRNA expression in RTOG endometrial cancer clinical trials 9708 and 9905 . OBJECTIVE To explore the association of a functional germline variant in the 3'-UTR of KRAS with endometrial cancer risk , as well as the association of microRNA ( miRNA ) signatures and the KRAS-variant with clinical characteristics and survival outcomes in two prospective RTOG endometrial cancer trials . METHODS/MATERIALS The association of the KRAS-variant with endometrial cancer risk was evaluated by case-control analysis of 467 women with type 1 or 2 endometrial cancer and 582 age-matched controls . miRNA and DNA were isolated for expression profiling and genotyping from tumor specimens of 46 women with type 1 endometrial cancer enrolled in RTOG trials 9708 and 9905. miRNA expression levels and KRAS-variant genotype were correlated with patient and tumor characteristics , and survival outcomes were evaluated by variant allele type . RESULTS The KRAS-variant was not significantly associated with overall endometrial cancer risk ( 14 % controls and 17 % type 1 cancers ) , although was enriched in type 2 endometrial cancers ( 24 % , p = 0.2 ) . In the combined analysis of RTOG 9708/9905 , miRNA expression differed by age , presence of lymphovascular invasion and KRAS-variant status . Overall survival rates at 3 years for patients with the variant and wild-type alleles were 100 % and 77 % ( HR 0.3 , p = 0.24 ) , respectively , favoring the variant . CONCLUSIONS The KRAS-variant may be a genetic marker of risk for type 2 endometrial cancers . In addition , tumor miRNA expression appears to be associated with patient age , lymphovascular invasion and the KRAS-variant , supporting the hypothesis that altered tumor biology can be measured by miRNA expression , and that the KRAS-variant likely impacts endometrial tumor biology . Instructions: please typing these entity words according to sentence: endometrial cancer, 467, women, type 1 or 2 endometrial cancer, tumor, type 1 endometrial cancer, overall endometrial cancer risk, 9708/9905 , miRNA expression, status, Overall survival rates, variant and wild - type alleles Options: Participant_Sex, Participant_Condition, Outcome_Mortality, Outcome_Physical, Participant_Sample-size, Outcome_Other	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "B-Participant_Sex", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The KRAS-variant and miRNA expression in RTOG endometrial cancer clinical trials 9708 and 9905 . OBJECTIVE To explore the association of a functional germline variant in the 3'-UTR of KRAS with endometrial cancer risk , as well as the association of microRNA ( miRNA ) signatures and the KRAS-variant with clinical characteristics and survival outcomes in two prospective RTOG endometrial cancer trials . METHODS/MATERIALS The association of the KRAS-variant with endometrial cancer risk was evaluated by case-control analysis of 467 women with type 1 or 2 endometrial cancer and 582 age-matched controls . miRNA and DNA were isolated for expression profiling and genotyping from tumor specimens of 46 women with type 1 endometrial cancer enrolled in RTOG trials 9708 and 9905. miRNA expression levels and KRAS-variant genotype were correlated with patient and tumor characteristics , and survival outcomes were evaluated by variant allele type . RESULTS The KRAS-variant was not significantly associated with overall endometrial cancer risk ( 14 % controls and 17 % type 1 cancers ) , although was enriched in type 2 endometrial cancers ( 24 % , p = 0.2 ) . In the combined analysis of RTOG 9708/9905 , miRNA expression differed by age , presence of lymphovascular invasion and KRAS-variant status . Overall survival rates at 3 years for patients with the variant and wild-type alleles were 100 % and 77 % ( HR 0.3 , p = 0.24 ) , respectively , favoring the variant . CONCLUSIONS The KRAS-variant may be a genetic marker of risk for type 2 endometrial cancers . In addition , tumor miRNA expression appears to be associated with patient age , lymphovascular invasion and the KRAS-variant , supporting the hypothesis that altered tumor biology can be measured by miRNA expression , and that the KRAS-variant likely impacts endometrial tumor biology .	[ "The", "KRAS", "-", "variant", "and", "miRNA", "expression", "in", "RTOG", "endometrial", "cancer", "clinical", "trials", "9708", "and", "9905", ".", "OBJECTIVE", "To", "explore", "the", "association", "of", "a", "functional", "germline", "variant", "in", "the", "3'-UTR", "of", "KRAS", "with", "endometrial", "cancer", "risk", ",", "as", "well", "as", "the", "association", "of", "microRNA", "(", "miRNA", ")", "signatures", "and", "the", "KRAS", "-", "variant", "with", "clinical", "characteristics", "and", "survival", "outcomes", "in", "two", "prospective", "RTOG", "endometrial", "cancer", "trials", ".", "METHODS", "/", "MATERIALS", "The", "association", "of", "the", "KRAS", "-", "variant", "with", "endometrial", "cancer", "risk", "was", "evaluated", "by", "case", "-", "control", "analysis", "of", "467", "women", "with", "type", "1", "or", "2", "endometrial", "cancer", "and", "582", "age", "-", "matched", "controls", ".", "miRNA", "and", "DNA", "were", "isolated", "for", "expression", "profiling", "and", "genotyping", "from", "tumor", "specimens", "of", "46", "women", "with", "type", "1", "endometrial", "cancer", "enrolled", "in", "RTOG", "trials", "9708", "and", "9905", ".", "miRNA", "expression", "levels", "and", "KRAS", "-", "variant", "genotype", "were", "correlated", "with", "patient", "and", "tumor", "characteristics", ",", "and", "survival", "outcomes", "were", "evaluated", "by", "variant", "allele", "type", ".", "RESULTS", "The", "KRAS", "-", "variant", "was", "not", "significantly", "associated", "with", "overall", "endometrial", "cancer", "risk", "(", "14", "%", "controls", "and", "17", "%", "type", "1", "cancers", ")", ",", "although", "was", "enriched", "in", "type", "2", "endometrial", "cancers", "(", "24", "%", ",", "p", "=", "0.2", ")", ".", "In", "the", "combined", "analysis", "of", "RTOG", "9708/9905", ",", "miRNA", "expression", "differed", "by", "age", ",", "presence", "of", "lymphovascular", "invasion", "and", "KRAS", "-", "variant", "status", ".", "Overall", "survival", "rates", "at", "3", "years", "for", "patients", "with", "the", "variant", "and", "wild", "-", "type", "alleles", "were", "100", "%", "and", "77", "%", "(", "HR", "0.3", ",", "p", "=", "0.24", ")", ",", "respectively", ",", "favoring", "the", "variant", ".", "CONCLUSIONS", "The", "KRAS", "-", "variant", "may", "be", "a", "genetic", "marker", "of", "risk", "for", "type", "2", "endometrial", "cancers", ".", "In", "addition", ",", "tumor", "miRNA", "expression", "appears", "to", "be", "associated", "with", "patient", "age", ",", "lymphovascular", "invasion", "and", "the", "KRAS", "-", "variant", ",", "supporting", "the", "hypothesis", "that", "altered", "tumor", "biology", "can", "be", "measured", "by", "miRNA", "expression", ",", "and", "that", "the", "KRAS", "-", "variant", "likely", "impacts", "endometrial", "tumor", "biology", "." ]	[ "Outcome_Physical", "Participant_Condition", "Outcome_Other", "Outcome_Mortality", "Participant_Sex", "Participant_Sample-size" ]
endometrial cancer, 467, women, type 1 or 2 endometrial cancer, tumor, type 1 endometrial cancer, overall endometrial cancer risk, 9708/9905 , miRNA expression, status, Overall survival rates, variant and wild - type alleles	65129_task2	Sentence: The KRAS-variant and miRNA expression in RTOG endometrial cancer clinical trials 9708 and 9905 . OBJECTIVE To explore the association of a functional germline variant in the 3'-UTR of KRAS with endometrial cancer risk , as well as the association of microRNA ( miRNA ) signatures and the KRAS-variant with clinical characteristics and survival outcomes in two prospective RTOG endometrial cancer trials . METHODS/MATERIALS The association of the KRAS-variant with endometrial cancer risk was evaluated by case-control analysis of 467 women with type 1 or 2 endometrial cancer and 582 age-matched controls . miRNA and DNA were isolated for expression profiling and genotyping from tumor specimens of 46 women with type 1 endometrial cancer enrolled in RTOG trials 9708 and 9905. miRNA expression levels and KRAS-variant genotype were correlated with patient and tumor characteristics , and survival outcomes were evaluated by variant allele type . RESULTS The KRAS-variant was not significantly associated with overall endometrial cancer risk ( 14 % controls and 17 % type 1 cancers ) , although was enriched in type 2 endometrial cancers ( 24 % , p = 0.2 ) . In the combined analysis of RTOG 9708/9905 , miRNA expression differed by age , presence of lymphovascular invasion and KRAS-variant status . Overall survival rates at 3 years for patients with the variant and wild-type alleles were 100 % and 77 % ( HR 0.3 , p = 0.24 ) , respectively , favoring the variant . CONCLUSIONS The KRAS-variant may be a genetic marker of risk for type 2 endometrial cancers . In addition , tumor miRNA expression appears to be associated with patient age , lymphovascular invasion and the KRAS-variant , supporting the hypothesis that altered tumor biology can be measured by miRNA expression , and that the KRAS-variant likely impacts endometrial tumor biology . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "B-Participant_Sex", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The KRAS-variant and miRNA expression in RTOG endometrial cancer clinical trials 9708 and 9905 . OBJECTIVE To explore the association of a functional germline variant in the 3'-UTR of KRAS with endometrial cancer risk , as well as the association of microRNA ( miRNA ) signatures and the KRAS-variant with clinical characteristics and survival outcomes in two prospective RTOG endometrial cancer trials . METHODS/MATERIALS The association of the KRAS-variant with endometrial cancer risk was evaluated by case-control analysis of 467 women with type 1 or 2 endometrial cancer and 582 age-matched controls . miRNA and DNA were isolated for expression profiling and genotyping from tumor specimens of 46 women with type 1 endometrial cancer enrolled in RTOG trials 9708 and 9905. miRNA expression levels and KRAS-variant genotype were correlated with patient and tumor characteristics , and survival outcomes were evaluated by variant allele type . RESULTS The KRAS-variant was not significantly associated with overall endometrial cancer risk ( 14 % controls and 17 % type 1 cancers ) , although was enriched in type 2 endometrial cancers ( 24 % , p = 0.2 ) . In the combined analysis of RTOG 9708/9905 , miRNA expression differed by age , presence of lymphovascular invasion and KRAS-variant status . Overall survival rates at 3 years for patients with the variant and wild-type alleles were 100 % and 77 % ( HR 0.3 , p = 0.24 ) , respectively , favoring the variant . CONCLUSIONS The KRAS-variant may be a genetic marker of risk for type 2 endometrial cancers . In addition , tumor miRNA expression appears to be associated with patient age , lymphovascular invasion and the KRAS-variant , supporting the hypothesis that altered tumor biology can be measured by miRNA expression , and that the KRAS-variant likely impacts endometrial tumor biology .	[ "The", "KRAS", "-", "variant", "and", "miRNA", "expression", "in", "RTOG", "endometrial", "cancer", "clinical", "trials", "9708", "and", "9905", ".", "OBJECTIVE", "To", "explore", "the", "association", "of", "a", "functional", "germline", "variant", "in", "the", "3'-UTR", "of", "KRAS", "with", "endometrial", "cancer", "risk", ",", "as", "well", "as", "the", "association", "of", "microRNA", "(", "miRNA", ")", "signatures", "and", "the", "KRAS", "-", "variant", "with", "clinical", "characteristics", "and", "survival", "outcomes", "in", "two", "prospective", "RTOG", "endometrial", "cancer", "trials", ".", "METHODS", "/", "MATERIALS", "The", "association", "of", "the", "KRAS", "-", "variant", "with", "endometrial", "cancer", "risk", "was", "evaluated", "by", "case", "-", "control", "analysis", "of", "467", "women", "with", "type", "1", "or", "2", "endometrial", "cancer", "and", "582", "age", "-", "matched", "controls", ".", "miRNA", "and", "DNA", "were", "isolated", "for", "expression", "profiling", "and", "genotyping", "from", "tumor", "specimens", "of", "46", "women", "with", "type", "1", "endometrial", "cancer", "enrolled", "in", "RTOG", "trials", "9708", "and", "9905", ".", "miRNA", "expression", "levels", "and", "KRAS", "-", "variant", "genotype", "were", "correlated", "with", "patient", "and", "tumor", "characteristics", ",", "and", "survival", "outcomes", "were", "evaluated", "by", "variant", "allele", "type", ".", "RESULTS", "The", "KRAS", "-", "variant", "was", "not", "significantly", "associated", "with", "overall", "endometrial", "cancer", "risk", "(", "14", "%", "controls", "and", "17", "%", "type", "1", "cancers", ")", ",", "although", "was", "enriched", "in", "type", "2", "endometrial", "cancers", "(", "24", "%", ",", "p", "=", "0.2", ")", ".", "In", "the", "combined", "analysis", "of", "RTOG", "9708/9905", ",", "miRNA", "expression", "differed", "by", "age", ",", "presence", "of", "lymphovascular", "invasion", "and", "KRAS", "-", "variant", "status", ".", "Overall", "survival", "rates", "at", "3", "years", "for", "patients", "with", "the", "variant", "and", "wild", "-", "type", "alleles", "were", "100", "%", "and", "77", "%", "(", "HR", "0.3", ",", "p", "=", "0.24", ")", ",", "respectively", ",", "favoring", "the", "variant", ".", "CONCLUSIONS", "The", "KRAS", "-", "variant", "may", "be", "a", "genetic", "marker", "of", "risk", "for", "type", "2", "endometrial", "cancers", ".", "In", "addition", ",", "tumor", "miRNA", "expression", "appears", "to", "be", "associated", "with", "patient", "age", ",", "lymphovascular", "invasion", "and", "the", "KRAS", "-", "variant", ",", "supporting", "the", "hypothesis", "that", "altered", "tumor", "biology", "can", "be", "measured", "by", "miRNA", "expression", ",", "and", "that", "the", "KRAS", "-", "variant", "likely", "impacts", "endometrial", "tumor", "biology", "." ]	[ "Outcome_Physical", "Participant_Condition", "Outcome_Other", "Outcome_Mortality", "Participant_Sex", "Participant_Sample-size" ]
oestrogenabhaengige is an umlsterm, Mammakarzinomen is an umlsterm, Therapie is an umlsterm, Mammakarzinomen is an umlsterm, formalinfixierten is an umlsterm, Paraffin is an umlsterm, Gewebeschnitten is an umlsterm, Konzentrationen is an umlsterm, Zytosol is an umlsterm, immunradiometrisch is an umlsterm, Tumoren is an umlsterm, Tumoren is an umlsterm, Karzinomgewebe is an umlsterm, Menopausenstatus is an umlsterm, Tumoren is an umlsterm, Oestrogen- is an umlsterm, Progesteronrezeptoren is an umlsterm, Tumoren is an umlsterm, Inzidenz is an umlsterm, steroidrezeptorpositiver is an umlsterm, Karzinome is an umlsterm, steroidrezeptornegativen is an umlsterm, Tumoren is an umlsterm	DerPathologe.50160278.ger.abstr_task0	Sentence: Die Synthese des pS 2-Proteins wird durch die oestrogenabhaengige Transkription des pS 2-Gens induziert . Dem Nachweis des pS 2-Proteins in Mammakarzinomen soll eine im Vergleich zum Rezeptorstatus gleichwertige oder hoehere Voraussagekraft hinsichtlich des Ansprechens auf eine hormonelle Therapie zukommen . Ebenso wird dem pS 2-Proteinnachweis eine prognostische Bedeutung zugesprochen . In 162 primaeren Mammakarzinomen wurde der pS 2-Nachweis an formalinfixierten und in Paraffin eingebetteten Gewebeschnitten durchgefuehrt und mittels eines immunreaktiven Score ( IRS ) semiquantitativ immunhistochemisch beurteilt . Die Konzentrationen des pS 2-Proteins im Zytosol wurde immunradiometrisch bestimmt . 27 % der Tumoren waren immunhistochemisch pS 2-positiv ( IRS > = 2 ) . Der Vergleich mit der biochemischen pS 2-Nachweismethode ( 26 % positive Tumoren bei einem Cut-off von 26 ng/mg Zytosolprotein ) erbrachte in 81 % eine konkordante qualitative Aussage des pS 2-Status ( r = 0,76 , p 0,0001 ) . Der immunhistochemische Nachweis von pS 2 im Karzinomgewebe korrelierte weder zum Alter oder Menopausenstatus der Patientinnen , noch zu Groesse oder Differenzierungsgrad der Tumoren oder zum Nodalstatus . Der immunhistochemische pS 2-Status korrelierte aber signifikant mit dem immunhistochemischen Nachweis der Oestrogen- ( ER , p 0,001 ) und Progesteronrezeptoren ( PR ; p 0,0001 ) . pS 2-positive Tumoren wiesen in 66 % einen positiven ER- und in 73 % einen positiven PR-Status auf bzw. waren in 89 % ER+ und/oder PR+. Die Inzidenz des immunhistochemischen pS 2-Nachweises lag in der Gruppe steroidrezeptorpositiver Karzinome ( ER und/oder PR positiv ) bei 41 % im Gegensatz zu 7 % bei steroidrezeptornegativen Tumoren ( ER und PR negativ ) . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]	Die Synthese des pS 2-Proteins wird durch die oestrogenabhaengige Transkription des pS 2-Gens induziert . Dem Nachweis des pS 2-Proteins in Mammakarzinomen soll eine im Vergleich zum Rezeptorstatus gleichwertige oder hoehere Voraussagekraft hinsichtlich des Ansprechens auf eine hormonelle Therapie zukommen . Ebenso wird dem pS 2-Proteinnachweis eine prognostische Bedeutung zugesprochen . In 162 primaeren Mammakarzinomen wurde der pS 2-Nachweis an formalinfixierten und in Paraffin eingebetteten Gewebeschnitten durchgefuehrt und mittels eines immunreaktiven Score ( IRS ) semiquantitativ immunhistochemisch beurteilt . Die Konzentrationen des pS 2-Proteins im Zytosol wurde immunradiometrisch bestimmt . 27 % der Tumoren waren immunhistochemisch pS 2-positiv ( IRS > = 2 ) . Der Vergleich mit der biochemischen pS 2-Nachweismethode ( 26 % positive Tumoren bei einem Cut-off von 26 ng/mg Zytosolprotein ) erbrachte in 81 % eine konkordante qualitative Aussage des pS 2-Status ( r = 0,76 , p 0,0001 ) . Der immunhistochemische Nachweis von pS 2 im Karzinomgewebe korrelierte weder zum Alter oder Menopausenstatus der Patientinnen , noch zu Groesse oder Differenzierungsgrad der Tumoren oder zum Nodalstatus . Der immunhistochemische pS 2-Status korrelierte aber signifikant mit dem immunhistochemischen Nachweis der Oestrogen- ( ER , p 0,001 ) und Progesteronrezeptoren ( PR ; p 0,0001 ) . pS 2-positive Tumoren wiesen in 66 % einen positiven ER- und in 73 % einen positiven PR-Status auf bzw. waren in 89 % ER+ und/oder PR+. Die Inzidenz des immunhistochemischen pS 2-Nachweises lag in der Gruppe steroidrezeptorpositiver Karzinome ( ER und/oder PR positiv ) bei 41 % im Gegensatz zu 7 % bei steroidrezeptornegativen Tumoren ( ER und PR negativ ) .	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oestrogenabhaengige is an umlsterm, Mammakarzinomen is an umlsterm, Therapie is an umlsterm, Mammakarzinomen is an umlsterm, formalinfixierten is an umlsterm, Paraffin is an umlsterm, Gewebeschnitten is an umlsterm, Konzentrationen is an umlsterm, Zytosol is an umlsterm, immunradiometrisch is an umlsterm, Tumoren is an umlsterm, Tumoren is an umlsterm, Karzinomgewebe is an umlsterm, Menopausenstatus is an umlsterm, Tumoren is an umlsterm, Oestrogen- is an umlsterm, Progesteronrezeptoren is an umlsterm, Tumoren is an umlsterm, Inzidenz is an umlsterm, steroidrezeptorpositiver is an umlsterm, Karzinome is an umlsterm, steroidrezeptornegativen is an umlsterm, Tumoren is an umlsterm	DerPathologe.50160278.ger.abstr_task1	Sentence: Die Synthese des pS 2-Proteins wird durch die oestrogenabhaengige Transkription des pS 2-Gens induziert . Dem Nachweis des pS 2-Proteins in Mammakarzinomen soll eine im Vergleich zum Rezeptorstatus gleichwertige oder hoehere Voraussagekraft hinsichtlich des Ansprechens auf eine hormonelle Therapie zukommen . Ebenso wird dem pS 2-Proteinnachweis eine prognostische Bedeutung zugesprochen . In 162 primaeren Mammakarzinomen wurde der pS 2-Nachweis an formalinfixierten und in Paraffin eingebetteten Gewebeschnitten durchgefuehrt und mittels eines immunreaktiven Score ( IRS ) semiquantitativ immunhistochemisch beurteilt . Die Konzentrationen des pS 2-Proteins im Zytosol wurde immunradiometrisch bestimmt . 27 % der Tumoren waren immunhistochemisch pS 2-positiv ( IRS > = 2 ) . Der Vergleich mit der biochemischen pS 2-Nachweismethode ( 26 % positive Tumoren bei einem Cut-off von 26 ng/mg Zytosolprotein ) erbrachte in 81 % eine konkordante qualitative Aussage des pS 2-Status ( r = 0,76 , p 0,0001 ) . Der immunhistochemische Nachweis von pS 2 im Karzinomgewebe korrelierte weder zum Alter oder Menopausenstatus der Patientinnen , noch zu Groesse oder Differenzierungsgrad der Tumoren oder zum Nodalstatus . Der immunhistochemische pS 2-Status korrelierte aber signifikant mit dem immunhistochemischen Nachweis der Oestrogen- ( ER , p 0,001 ) und Progesteronrezeptoren ( PR ; p 0,0001 ) . pS 2-positive Tumoren wiesen in 66 % einen positiven ER- und in 73 % einen positiven PR-Status auf bzw. waren in 89 % ER+ und/oder PR+. Die Inzidenz des immunhistochemischen pS 2-Nachweises lag in der Gruppe steroidrezeptorpositiver Karzinome ( ER und/oder PR positiv ) bei 41 % im Gegensatz zu 7 % bei steroidrezeptornegativen Tumoren ( ER und PR negativ ) . Instructions: please typing these entity words according to sentence: oestrogenabhaengige, Mammakarzinomen, Therapie, Mammakarzinomen, formalinfixierten, Paraffin, Gewebeschnitten, Konzentrationen, Zytosol, immunradiometrisch, Tumoren, Tumoren, Karzinomgewebe, Menopausenstatus, Tumoren, Oestrogen-, Progesteronrezeptoren, Tumoren, Inzidenz, steroidrezeptorpositiver, Karzinome, steroidrezeptornegativen, Tumoren Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]	Die Synthese des pS 2-Proteins wird durch die oestrogenabhaengige Transkription des pS 2-Gens induziert . Dem Nachweis des pS 2-Proteins in Mammakarzinomen soll eine im Vergleich zum Rezeptorstatus gleichwertige oder hoehere Voraussagekraft hinsichtlich des Ansprechens auf eine hormonelle Therapie zukommen . Ebenso wird dem pS 2-Proteinnachweis eine prognostische Bedeutung zugesprochen . In 162 primaeren Mammakarzinomen wurde der pS 2-Nachweis an formalinfixierten und in Paraffin eingebetteten Gewebeschnitten durchgefuehrt und mittels eines immunreaktiven Score ( IRS ) semiquantitativ immunhistochemisch beurteilt . Die Konzentrationen des pS 2-Proteins im Zytosol wurde immunradiometrisch bestimmt . 27 % der Tumoren waren immunhistochemisch pS 2-positiv ( IRS > = 2 ) . Der Vergleich mit der biochemischen pS 2-Nachweismethode ( 26 % positive Tumoren bei einem Cut-off von 26 ng/mg Zytosolprotein ) erbrachte in 81 % eine konkordante qualitative Aussage des pS 2-Status ( r = 0,76 , p 0,0001 ) . Der immunhistochemische Nachweis von pS 2 im Karzinomgewebe korrelierte weder zum Alter oder Menopausenstatus der Patientinnen , noch zu Groesse oder Differenzierungsgrad der Tumoren oder zum Nodalstatus . Der immunhistochemische pS 2-Status korrelierte aber signifikant mit dem immunhistochemischen Nachweis der Oestrogen- ( ER , p 0,001 ) und Progesteronrezeptoren ( PR ; p 0,0001 ) . pS 2-positive Tumoren wiesen in 66 % einen positiven ER- und in 73 % einen positiven PR-Status auf bzw. waren in 89 % ER+ und/oder PR+. Die Inzidenz des immunhistochemischen pS 2-Nachweises lag in der Gruppe steroidrezeptorpositiver Karzinome ( ER und/oder PR positiv ) bei 41 % im Gegensatz zu 7 % bei steroidrezeptornegativen Tumoren ( ER und PR negativ ) .	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oestrogenabhaengige, Mammakarzinomen, Therapie, Mammakarzinomen, formalinfixierten, Paraffin, Gewebeschnitten, Konzentrationen, Zytosol, immunradiometrisch, Tumoren, Tumoren, Karzinomgewebe, Menopausenstatus, Tumoren, Oestrogen-, Progesteronrezeptoren, Tumoren, Inzidenz, steroidrezeptorpositiver, Karzinome, steroidrezeptornegativen, Tumoren	DerPathologe.50160278.ger.abstr_task2	Sentence: Die Synthese des pS 2-Proteins wird durch die oestrogenabhaengige Transkription des pS 2-Gens induziert . Dem Nachweis des pS 2-Proteins in Mammakarzinomen soll eine im Vergleich zum Rezeptorstatus gleichwertige oder hoehere Voraussagekraft hinsichtlich des Ansprechens auf eine hormonelle Therapie zukommen . Ebenso wird dem pS 2-Proteinnachweis eine prognostische Bedeutung zugesprochen . In 162 primaeren Mammakarzinomen wurde der pS 2-Nachweis an formalinfixierten und in Paraffin eingebetteten Gewebeschnitten durchgefuehrt und mittels eines immunreaktiven Score ( IRS ) semiquantitativ immunhistochemisch beurteilt . Die Konzentrationen des pS 2-Proteins im Zytosol wurde immunradiometrisch bestimmt . 27 % der Tumoren waren immunhistochemisch pS 2-positiv ( IRS > = 2 ) . Der Vergleich mit der biochemischen pS 2-Nachweismethode ( 26 % positive Tumoren bei einem Cut-off von 26 ng/mg Zytosolprotein ) erbrachte in 81 % eine konkordante qualitative Aussage des pS 2-Status ( r = 0,76 , p 0,0001 ) . Der immunhistochemische Nachweis von pS 2 im Karzinomgewebe korrelierte weder zum Alter oder Menopausenstatus der Patientinnen , noch zu Groesse oder Differenzierungsgrad der Tumoren oder zum Nodalstatus . Der immunhistochemische pS 2-Status korrelierte aber signifikant mit dem immunhistochemischen Nachweis der Oestrogen- ( ER , p 0,001 ) und Progesteronrezeptoren ( PR ; p 0,0001 ) . pS 2-positive Tumoren wiesen in 66 % einen positiven ER- und in 73 % einen positiven PR-Status auf bzw. waren in 89 % ER+ und/oder PR+. Die Inzidenz des immunhistochemischen pS 2-Nachweises lag in der Gruppe steroidrezeptorpositiver Karzinome ( ER und/oder PR positiv ) bei 41 % im Gegensatz zu 7 % bei steroidrezeptornegativen Tumoren ( ER und PR negativ ) . 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Dem Nachweis des pS 2-Proteins in Mammakarzinomen soll eine im Vergleich zum Rezeptorstatus gleichwertige oder hoehere Voraussagekraft hinsichtlich des Ansprechens auf eine hormonelle Therapie zukommen . Ebenso wird dem pS 2-Proteinnachweis eine prognostische Bedeutung zugesprochen . In 162 primaeren Mammakarzinomen wurde der pS 2-Nachweis an formalinfixierten und in Paraffin eingebetteten Gewebeschnitten durchgefuehrt und mittels eines immunreaktiven Score ( IRS ) semiquantitativ immunhistochemisch beurteilt . Die Konzentrationen des pS 2-Proteins im Zytosol wurde immunradiometrisch bestimmt . 27 % der Tumoren waren immunhistochemisch pS 2-positiv ( IRS > = 2 ) . Der Vergleich mit der biochemischen pS 2-Nachweismethode ( 26 % positive Tumoren bei einem Cut-off von 26 ng/mg Zytosolprotein ) erbrachte in 81 % eine konkordante qualitative Aussage des pS 2-Status ( r = 0,76 , p 0,0001 ) . Der immunhistochemische Nachweis von pS 2 im Karzinomgewebe korrelierte weder zum Alter oder Menopausenstatus der Patientinnen , noch zu Groesse oder Differenzierungsgrad der Tumoren oder zum Nodalstatus . Der immunhistochemische pS 2-Status korrelierte aber signifikant mit dem immunhistochemischen Nachweis der Oestrogen- ( ER , p 0,001 ) und Progesteronrezeptoren ( PR ; p 0,0001 ) . pS 2-positive Tumoren wiesen in 66 % einen positiven ER- und in 73 % einen positiven PR-Status auf bzw. waren in 89 % ER+ und/oder PR+. Die Inzidenz des immunhistochemischen pS 2-Nachweises lag in der Gruppe steroidrezeptorpositiver Karzinome ( ER und/oder PR positiv ) bei 41 % im Gegensatz zu 7 % bei steroidrezeptornegativen Tumoren ( ER und PR negativ ) .	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Tetraplegie is an umlsterm, Patientenauswahl is an umlsterm, Patienten is an umlsterm, supraventrikulaere Tachykardien is an umlsterm, Ventrikulaere Tachykardien is an umlsterm, Bradykardien is an umlsterm, Patient is an umlsterm, Blutdruckwerte is an umlsterm, Blutdruckabfaelle is an umlsterm, Afferente is an umlsterm, Konduktionsbloecke is an umlsterm, Afferente is an umlsterm, Katecholaminexzesse is an umlsterm, Tachykardie is an umlsterm, Hyperglykaemie is an umlsterm, Dehnungsrezeptoren is an umlsterm, Blutdrucklabilitaet is an umlsterm, Risikofaktoren is an umlsterm, Tetraplegie is an umlsterm, Propriozeption is an umlsterm, Blutdrucklabilitaet is an umlsterm, Patienten is an umlsterm	DerNervenarzt.90700136.ger.abstr_task0	Sentence: Bei GBS-Patienten mit Tetraplegie oder propriozeptiven Ausfaellen sind vegetative Stoerungen haeufig und nicht selten bedrohlich . Je nach verwendetem Grenzwert und abhaengig von der Patientenauswahl haben 20-75% der Patienten supraventrikulaere Tachykardien . Ventrikulaere Tachykardien sind seltener vital bedrohlich als Bradykardien , die spontan und nach verschiedenen thorakalen und orofazialen Reizen auftreten koennen . Etwa jeder fuenfte Patient ist dauerhafter hyperton . Typisch sind bizarr schwankende Blutdruckwerte . Seltener stehen Blutdruckabfaelle im Vordergrund . Afferente Konduktionsbloecke entzuegeln diverse Efferenzen . So kommt es bei Ausfall sinoatrialer Dehnungsafferenzen zur unangemessenen ADH- und Reninausschuettung . Afferente Stoerungen des Barorezeptorreflexes verursachen Katecholaminexzesse , die zu Hypertonus , Tachykardie , EKG-Veraenderungen und Hyperglykaemie fuehren . Ausserdem steigern sie die Empfindlichkeit unmyeliniserter linksventrikulaerer Dehnungsrezeptoren , die kardio- und vasodepressorisch wirken und zur Blutdrucklabilitaet beitragen . Intakt gebliebene unmyelinisierte Afferenzen vermitteln nicht selten bradykarde Reaktionen , v.a. wenn das Gegengewicht tachykard wirkender myelinisierter Afferenzen verloren gegangen ist . Ein Beispiel sind hochschwellige unmyelinisierte pulmonale Dehnungsafferenzen , die bei der Seufzerbeatmung stimuliert werden . Die Kenntnis der klinischen Risikofaktoren Tetraplegie und gestoerte Propriozeption , des wichtigsten Dysautonomieindikators Blutdrucklabilitaet und die Anwendung vegetativer Funktionstests helfen , bedrohte Patienten zu erkennen , die kardial ueberwacht werden muessen . Angesichts der haeufigen afferenten Fehlmeldungen ist eine sympathische und parasympathische Blockade unter Schrittmacherbereitschaft zu erwaegen . 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Je nach verwendetem Grenzwert und abhaengig von der Patientenauswahl haben 20-75% der Patienten supraventrikulaere Tachykardien . Ventrikulaere Tachykardien sind seltener vital bedrohlich als Bradykardien , die spontan und nach verschiedenen thorakalen und orofazialen Reizen auftreten koennen . Etwa jeder fuenfte Patient ist dauerhafter hyperton . Typisch sind bizarr schwankende Blutdruckwerte . Seltener stehen Blutdruckabfaelle im Vordergrund . Afferente Konduktionsbloecke entzuegeln diverse Efferenzen . So kommt es bei Ausfall sinoatrialer Dehnungsafferenzen zur unangemessenen ADH- und Reninausschuettung . Afferente Stoerungen des Barorezeptorreflexes verursachen Katecholaminexzesse , die zu Hypertonus , Tachykardie , EKG-Veraenderungen und Hyperglykaemie fuehren . Ausserdem steigern sie die Empfindlichkeit unmyeliniserter linksventrikulaerer Dehnungsrezeptoren , die kardio- und vasodepressorisch wirken und zur Blutdrucklabilitaet beitragen . Intakt gebliebene unmyelinisierte Afferenzen vermitteln nicht selten bradykarde Reaktionen , v.a. wenn das Gegengewicht tachykard wirkender myelinisierter Afferenzen verloren gegangen ist . Ein Beispiel sind hochschwellige unmyelinisierte pulmonale Dehnungsafferenzen , die bei der Seufzerbeatmung stimuliert werden . Die Kenntnis der klinischen Risikofaktoren Tetraplegie und gestoerte Propriozeption , des wichtigsten Dysautonomieindikators Blutdrucklabilitaet und die Anwendung vegetativer Funktionstests helfen , bedrohte Patienten zu erkennen , die kardial ueberwacht werden muessen . Angesichts der haeufigen afferenten Fehlmeldungen ist eine sympathische und parasympathische Blockade unter Schrittmacherbereitschaft zu erwaegen .	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Tetraplegie is an umlsterm, Patientenauswahl is an umlsterm, Patienten is an umlsterm, supraventrikulaere Tachykardien is an umlsterm, Ventrikulaere Tachykardien is an umlsterm, Bradykardien is an umlsterm, Patient is an umlsterm, Blutdruckwerte is an umlsterm, Blutdruckabfaelle is an umlsterm, Afferente is an umlsterm, Konduktionsbloecke is an umlsterm, Afferente is an umlsterm, Katecholaminexzesse is an umlsterm, Tachykardie is an umlsterm, Hyperglykaemie is an umlsterm, Dehnungsrezeptoren is an umlsterm, Blutdrucklabilitaet is an umlsterm, Risikofaktoren is an umlsterm, Tetraplegie is an umlsterm, Propriozeption is an umlsterm, Blutdrucklabilitaet is an umlsterm, Patienten is an umlsterm	DerNervenarzt.90700136.ger.abstr_task1	Sentence: Bei GBS-Patienten mit Tetraplegie oder propriozeptiven Ausfaellen sind vegetative Stoerungen haeufig und nicht selten bedrohlich . Je nach verwendetem Grenzwert und abhaengig von der Patientenauswahl haben 20-75% der Patienten supraventrikulaere Tachykardien . Ventrikulaere Tachykardien sind seltener vital bedrohlich als Bradykardien , die spontan und nach verschiedenen thorakalen und orofazialen Reizen auftreten koennen . Etwa jeder fuenfte Patient ist dauerhafter hyperton . Typisch sind bizarr schwankende Blutdruckwerte . Seltener stehen Blutdruckabfaelle im Vordergrund . Afferente Konduktionsbloecke entzuegeln diverse Efferenzen . So kommt es bei Ausfall sinoatrialer Dehnungsafferenzen zur unangemessenen ADH- und Reninausschuettung . Afferente Stoerungen des Barorezeptorreflexes verursachen Katecholaminexzesse , die zu Hypertonus , Tachykardie , EKG-Veraenderungen und Hyperglykaemie fuehren . Ausserdem steigern sie die Empfindlichkeit unmyeliniserter linksventrikulaerer Dehnungsrezeptoren , die kardio- und vasodepressorisch wirken und zur Blutdrucklabilitaet beitragen . Intakt gebliebene unmyelinisierte Afferenzen vermitteln nicht selten bradykarde Reaktionen , v.a. wenn das Gegengewicht tachykard wirkender myelinisierter Afferenzen verloren gegangen ist . Ein Beispiel sind hochschwellige unmyelinisierte pulmonale Dehnungsafferenzen , die bei der Seufzerbeatmung stimuliert werden . Die Kenntnis der klinischen Risikofaktoren Tetraplegie und gestoerte Propriozeption , des wichtigsten Dysautonomieindikators Blutdrucklabilitaet und die Anwendung vegetativer Funktionstests helfen , bedrohte Patienten zu erkennen , die kardial ueberwacht werden muessen . Angesichts der haeufigen afferenten Fehlmeldungen ist eine sympathische und parasympathische Blockade unter Schrittmacherbereitschaft zu erwaegen . Instructions: please typing these entity words according to sentence: Tetraplegie, Patientenauswahl, Patienten, supraventrikulaere Tachykardien, Ventrikulaere Tachykardien, Bradykardien, Patient, Blutdruckwerte, Blutdruckabfaelle, Afferente, Konduktionsbloecke, Afferente, Katecholaminexzesse, Tachykardie, Hyperglykaemie, Dehnungsrezeptoren, Blutdrucklabilitaet, Risikofaktoren, Tetraplegie, Propriozeption, Blutdrucklabilitaet, Patienten Options: umlsterm	[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Bei GBS-Patienten mit Tetraplegie oder propriozeptiven Ausfaellen sind vegetative Stoerungen haeufig und nicht selten bedrohlich . Je nach verwendetem Grenzwert und abhaengig von der Patientenauswahl haben 20-75% der Patienten supraventrikulaere Tachykardien . Ventrikulaere Tachykardien sind seltener vital bedrohlich als Bradykardien , die spontan und nach verschiedenen thorakalen und orofazialen Reizen auftreten koennen . Etwa jeder fuenfte Patient ist dauerhafter hyperton . Typisch sind bizarr schwankende Blutdruckwerte . Seltener stehen Blutdruckabfaelle im Vordergrund . Afferente Konduktionsbloecke entzuegeln diverse Efferenzen . So kommt es bei Ausfall sinoatrialer Dehnungsafferenzen zur unangemessenen ADH- und Reninausschuettung . Afferente Stoerungen des Barorezeptorreflexes verursachen Katecholaminexzesse , die zu Hypertonus , Tachykardie , EKG-Veraenderungen und Hyperglykaemie fuehren . Ausserdem steigern sie die Empfindlichkeit unmyeliniserter linksventrikulaerer Dehnungsrezeptoren , die kardio- und vasodepressorisch wirken und zur Blutdrucklabilitaet beitragen . Intakt gebliebene unmyelinisierte Afferenzen vermitteln nicht selten bradykarde Reaktionen , v.a. wenn das Gegengewicht tachykard wirkender myelinisierter Afferenzen verloren gegangen ist . Ein Beispiel sind hochschwellige unmyelinisierte pulmonale Dehnungsafferenzen , die bei der Seufzerbeatmung stimuliert werden . Die Kenntnis der klinischen Risikofaktoren Tetraplegie und gestoerte Propriozeption , des wichtigsten Dysautonomieindikators Blutdrucklabilitaet und die Anwendung vegetativer Funktionstests helfen , bedrohte Patienten zu erkennen , die kardial ueberwacht werden muessen . Angesichts der haeufigen afferenten Fehlmeldungen ist eine sympathische und parasympathische Blockade unter Schrittmacherbereitschaft zu erwaegen .	[ "Bei", "GBS", "-", "Patienten", "mit", "Tetraplegie", "oder", "propriozeptiven", "Ausfaellen", "sind", "vegetative", "Stoerungen", "haeufig", "und", "nicht", "selten", "bedrohlich", ".", "Je", "nach", "verwendetem", "Grenzwert", "und", "abhaengig", "von", "der", "Patientenauswahl", "haben", "20", "-", "75", "%", "der", "Patienten", "supraventrikulaere", "Tachykardien", ".", "Ventrikulaere", "Tachykardien", "sind", "seltener", "vital", "bedrohlich", "als", "Bradykardien", ",", "die", "spontan", "und", "nach", "verschiedenen", "thorakalen", "und", "orofazialen", "Reizen", "auftreten", "koennen", ".", "Etwa", "jeder", "fuenfte", "Patient", "ist", "dauerhafter", "hyperton", ".", "Typisch", "sind", "bizarr", "schwankende", "Blutdruckwerte", ".", "Seltener", "stehen", "Blutdruckabfaelle", "im", "Vordergrund", ".", "Afferente", "Konduktionsbloecke", "entzuegeln", "diverse", "Efferenzen", ".", "So", "kommt", "es", "bei", "Ausfall", "sinoatrialer", "Dehnungsafferenzen", "zur", "unangemessenen", "ADH-", "und", "Reninausschuettung", ".", "Afferente", "Stoerungen", "des", "Barorezeptorreflexes", "verursachen", "Katecholaminexzesse", ",", "die", "zu", "Hypertonus", ",", "Tachykardie", ",", "EKG", "-", "Veraenderungen", "und", "Hyperglykaemie", "fuehren", ".", "Ausserdem", "steigern", "sie", "die", "Empfindlichkeit", "unmyeliniserter", "linksventrikulaerer", "Dehnungsrezeptoren", ",", "die", "kardio-", "und", "vasodepressorisch", "wirken", "und", "zur", "Blutdrucklabilitaet", "beitragen", ".", "Intakt", "gebliebene", "unmyelinisierte", "Afferenzen", "vermitteln", "nicht", "selten", "bradykarde", "Reaktionen", ",", "v.a", ".", "wenn", "das", "Gegengewicht", "tachykard", "wirkender", "myelinisierter", "Afferenzen", "verloren", "gegangen", "ist", ".", "Ein", "Beispiel", "sind", "hochschwellige", "unmyelinisierte", "pulmonale", "Dehnungsafferenzen", ",", "die", "bei", "der", "Seufzerbeatmung", "stimuliert", "werden", ".", "Die", "Kenntnis", "der", "klinischen", "Risikofaktoren", "Tetraplegie", "und", "gestoerte", "Propriozeption", ",", "des", "wichtigsten", "Dysautonomieindikators", "Blutdrucklabilitaet", "und", "die", "Anwendung", "vegetativer", "Funktionstests", "helfen", ",", "bedrohte", "Patienten", "zu", "erkennen", ",", "die", "kardial", "ueberwacht", "werden", "muessen", ".", "Angesichts", "der", "haeufigen", "afferenten", "Fehlmeldungen", "ist", "eine", "sympathische", "und", "parasympathische", "Blockade", "unter", "Schrittmacherbereitschaft", "zu", "erwaegen", "." ]	[ "umlsterm" ]
Tetraplegie, Patientenauswahl, Patienten, supraventrikulaere Tachykardien, Ventrikulaere Tachykardien, Bradykardien, Patient, Blutdruckwerte, Blutdruckabfaelle, Afferente, Konduktionsbloecke, Afferente, Katecholaminexzesse, Tachykardie, Hyperglykaemie, Dehnungsrezeptoren, Blutdrucklabilitaet, Risikofaktoren, Tetraplegie, Propriozeption, Blutdrucklabilitaet, Patienten	DerNervenarzt.90700136.ger.abstr_task2	Sentence: Bei GBS-Patienten mit Tetraplegie oder propriozeptiven Ausfaellen sind vegetative Stoerungen haeufig und nicht selten bedrohlich . Je nach verwendetem Grenzwert und abhaengig von der Patientenauswahl haben 20-75% der Patienten supraventrikulaere Tachykardien . Ventrikulaere Tachykardien sind seltener vital bedrohlich als Bradykardien , die spontan und nach verschiedenen thorakalen und orofazialen Reizen auftreten koennen . Etwa jeder fuenfte Patient ist dauerhafter hyperton . Typisch sind bizarr schwankende Blutdruckwerte . Seltener stehen Blutdruckabfaelle im Vordergrund . Afferente Konduktionsbloecke entzuegeln diverse Efferenzen . So kommt es bei Ausfall sinoatrialer Dehnungsafferenzen zur unangemessenen ADH- und Reninausschuettung . Afferente Stoerungen des Barorezeptorreflexes verursachen Katecholaminexzesse , die zu Hypertonus , Tachykardie , EKG-Veraenderungen und Hyperglykaemie fuehren . Ausserdem steigern sie die Empfindlichkeit unmyeliniserter linksventrikulaerer Dehnungsrezeptoren , die kardio- und vasodepressorisch wirken und zur Blutdrucklabilitaet beitragen . Intakt gebliebene unmyelinisierte Afferenzen vermitteln nicht selten bradykarde Reaktionen , v.a. wenn das Gegengewicht tachykard wirkender myelinisierter Afferenzen verloren gegangen ist . Ein Beispiel sind hochschwellige unmyelinisierte pulmonale Dehnungsafferenzen , die bei der Seufzerbeatmung stimuliert werden . Die Kenntnis der klinischen Risikofaktoren Tetraplegie und gestoerte Propriozeption , des wichtigsten Dysautonomieindikators Blutdrucklabilitaet und die Anwendung vegetativer Funktionstests helfen , bedrohte Patienten zu erkennen , die kardial ueberwacht werden muessen . Angesichts der haeufigen afferenten Fehlmeldungen ist eine sympathische und parasympathische Blockade unter Schrittmacherbereitschaft zu erwaegen . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Bei GBS-Patienten mit Tetraplegie oder propriozeptiven Ausfaellen sind vegetative Stoerungen haeufig und nicht selten bedrohlich . Je nach verwendetem Grenzwert und abhaengig von der Patientenauswahl haben 20-75% der Patienten supraventrikulaere Tachykardien . Ventrikulaere Tachykardien sind seltener vital bedrohlich als Bradykardien , die spontan und nach verschiedenen thorakalen und orofazialen Reizen auftreten koennen . Etwa jeder fuenfte Patient ist dauerhafter hyperton . Typisch sind bizarr schwankende Blutdruckwerte . Seltener stehen Blutdruckabfaelle im Vordergrund . Afferente Konduktionsbloecke entzuegeln diverse Efferenzen . So kommt es bei Ausfall sinoatrialer Dehnungsafferenzen zur unangemessenen ADH- und Reninausschuettung . Afferente Stoerungen des Barorezeptorreflexes verursachen Katecholaminexzesse , die zu Hypertonus , Tachykardie , EKG-Veraenderungen und Hyperglykaemie fuehren . Ausserdem steigern sie die Empfindlichkeit unmyeliniserter linksventrikulaerer Dehnungsrezeptoren , die kardio- und vasodepressorisch wirken und zur Blutdrucklabilitaet beitragen . Intakt gebliebene unmyelinisierte Afferenzen vermitteln nicht selten bradykarde Reaktionen , v.a. wenn das Gegengewicht tachykard wirkender myelinisierter Afferenzen verloren gegangen ist . Ein Beispiel sind hochschwellige unmyelinisierte pulmonale Dehnungsafferenzen , die bei der Seufzerbeatmung stimuliert werden . Die Kenntnis der klinischen Risikofaktoren Tetraplegie und gestoerte Propriozeption , des wichtigsten Dysautonomieindikators Blutdrucklabilitaet und die Anwendung vegetativer Funktionstests helfen , bedrohte Patienten zu erkennen , die kardial ueberwacht werden muessen . Angesichts der haeufigen afferenten Fehlmeldungen ist eine sympathische und parasympathische Blockade unter Schrittmacherbereitschaft zu erwaegen .	[ "Bei", "GBS", "-", "Patienten", "mit", "Tetraplegie", "oder", "propriozeptiven", "Ausfaellen", "sind", "vegetative", "Stoerungen", "haeufig", "und", "nicht", "selten", "bedrohlich", ".", "Je", "nach", "verwendetem", "Grenzwert", "und", "abhaengig", "von", "der", "Patientenauswahl", "haben", "20", "-", "75", "%", "der", "Patienten", "supraventrikulaere", "Tachykardien", ".", "Ventrikulaere", "Tachykardien", "sind", "seltener", "vital", "bedrohlich", "als", "Bradykardien", ",", "die", "spontan", "und", "nach", "verschiedenen", "thorakalen", "und", "orofazialen", "Reizen", "auftreten", "koennen", ".", "Etwa", "jeder", "fuenfte", "Patient", "ist", "dauerhafter", "hyperton", ".", "Typisch", "sind", "bizarr", "schwankende", "Blutdruckwerte", ".", "Seltener", "stehen", "Blutdruckabfaelle", "im", "Vordergrund", ".", "Afferente", "Konduktionsbloecke", "entzuegeln", "diverse", "Efferenzen", ".", "So", "kommt", "es", "bei", "Ausfall", "sinoatrialer", "Dehnungsafferenzen", "zur", "unangemessenen", "ADH-", "und", "Reninausschuettung", ".", "Afferente", "Stoerungen", "des", "Barorezeptorreflexes", "verursachen", "Katecholaminexzesse", ",", "die", "zu", "Hypertonus", ",", "Tachykardie", ",", "EKG", "-", "Veraenderungen", "und", "Hyperglykaemie", "fuehren", ".", "Ausserdem", "steigern", "sie", "die", "Empfindlichkeit", "unmyeliniserter", "linksventrikulaerer", "Dehnungsrezeptoren", ",", "die", "kardio-", "und", "vasodepressorisch", "wirken", "und", "zur", "Blutdrucklabilitaet", "beitragen", ".", "Intakt", "gebliebene", "unmyelinisierte", "Afferenzen", "vermitteln", "nicht", "selten", "bradykarde", "Reaktionen", ",", "v.a", ".", "wenn", "das", "Gegengewicht", "tachykard", "wirkender", "myelinisierter", "Afferenzen", "verloren", "gegangen", "ist", ".", "Ein", "Beispiel", "sind", "hochschwellige", "unmyelinisierte", "pulmonale", "Dehnungsafferenzen", ",", "die", "bei", "der", "Seufzerbeatmung", "stimuliert", "werden", ".", "Die", "Kenntnis", "der", "klinischen", "Risikofaktoren", "Tetraplegie", "und", "gestoerte", "Propriozeption", ",", "des", "wichtigsten", "Dysautonomieindikators", "Blutdrucklabilitaet", "und", "die", "Anwendung", "vegetativer", "Funktionstests", "helfen", ",", "bedrohte", "Patienten", "zu", "erkennen", ",", "die", "kardial", "ueberwacht", "werden", "muessen", ".", "Angesichts", "der", "haeufigen", "afferenten", "Fehlmeldungen", "ist", "eine", "sympathische", "und", "parasympathische", "Blockade", "unter", "Schrittmacherbereitschaft", "zu", "erwaegen", "." ]	[ "umlsterm" ]
USF is a protein-family, DOR promoter is a DNA, Sp1 is a protein, Sp3 is a protein, NS20Y is a cell	1.0alpha7.train.474_task0	Sentence: Thus, binding of USF to the DOR promoter sequence is more critical than that of Sp1/Sp3 in NS20Y cells. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: DNA, cell, protein-family, protein	[ "O", "O", "O", "O", "O", "O", "B-protein-family", "O", "O", "O", "B-DNA", "I-DNA", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "B-protein", "O", "O", "B-cell", "O", "O", "O" ]	Thus, binding of USF to the DOR promoter sequence is more critical than that of Sp1/Sp3 in NS20Y cells.	[ " ", "Thus", ",", "binding", "of", " ", "USF", "to", "the", " ", "DOR", "promoter", "sequence", "is", "more", "critical", "than", "that", "of", " ", "Sp1", "/", "Sp3", "in", " ", "NS20Y", "cells", ".", " " ]	[ "DNA", "cell", "protein-family", "protein" ]
USF is a protein-family, DOR promoter is a DNA, Sp1 is a protein, Sp3 is a protein, NS20Y is a cell	1.0alpha7.train.474_task1	Sentence: Thus, binding of USF to the DOR promoter sequence is more critical than that of Sp1/Sp3 in NS20Y cells. Instructions: please typing these entity words according to sentence: USF, DOR promoter, Sp1, Sp3, NS20Y Options: DNA, cell, protein-family, protein	[ "O", "O", "O", "O", "O", "O", "B-protein-family", "O", "O", "O", "B-DNA", "I-DNA", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "B-protein", "O", "O", "B-cell", "O", "O", "O" ]	Thus, binding of USF to the DOR promoter sequence is more critical than that of Sp1/Sp3 in NS20Y cells.	[ " ", "Thus", ",", "binding", "of", " ", "USF", "to", "the", " ", "DOR", "promoter", "sequence", "is", "more", "critical", "than", "that", "of", " ", "Sp1", "/", "Sp3", "in", " ", "NS20Y", "cells", ".", " " ]	[ "DNA", "cell", "protein-family", "protein" ]
USF, DOR promoter, Sp1, Sp3, NS20Y	1.0alpha7.train.474_task2	Sentence: Thus, binding of USF to the DOR promoter sequence is more critical than that of Sp1/Sp3 in NS20Y cells. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-protein-family", "O", "O", "O", "B-DNA", "I-DNA", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "B-protein", "O", "O", "B-cell", "O", "O", "O" ]	Thus, binding of USF to the DOR promoter sequence is more critical than that of Sp1/Sp3 in NS20Y cells.	[ " ", "Thus", ",", "binding", "of", " ", "USF", "to", "the", " ", "DOR", "promoter", "sequence", "is", "more", "critical", "than", "that", "of", " ", "Sp1", "/", "Sp3", "in", " ", "NS20Y", "cells", ".", " " ]	[ "DNA", "cell", "protein-family", "protein" ]
Dermatologic disorders is an umlsterm, stump is an umlsterm, patients is an umlsterm, leg is an umlsterm, amputation is an umlsterm, knowledge is an umlsterm, diagnosis is an umlsterm, immobilization is an umlsterm, language is an umlsterm, review is an umlsterm, dermatology is an umlsterm, prostheses is an umlsterm, blisters is an umlsterm, keratoses is an umlsterm, epidermoid cysts is an umlsterm, stump is an umlsterm, edema is an umlsterm, syndrome is an umlsterm, sarcoma is an umlsterm, hyperplasia is an umlsterm	DerHautarzt.60470493.eng.abstr_task0	Sentence: Dermatologic disorders of the stump in patients with a leg amputation may have characteristic pathophysiologic and clinical features . A knowledge of these factors may lead to earlier diagnosis and avoid immobilization . There ist no German language review of this aspect of dermatology . After providing an overview of the problem , including a discussion of prostheses , we review the following problems : mechanically induced blisters , follicular keratoses , epidermoid cysts , stump edema syndrome , acroangiodermatitis ( pseudo-kaposi sarcoma ) and verrucous hyperplasia . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O" ]	Dermatologic disorders of the stump in patients with a leg amputation may have characteristic pathophysiologic and clinical features . A knowledge of these factors may lead to earlier diagnosis and avoid immobilization . There ist no German language review of this aspect of dermatology . After providing an overview of the problem , including a discussion of prostheses , we review the following problems : mechanically induced blisters , follicular keratoses , epidermoid cysts , stump edema syndrome , acroangiodermatitis ( pseudo-kaposi sarcoma ) and verrucous hyperplasia .	[ "Dermatologic", "disorders", "of", "the", "stump", "in", "patients", "with", "a", "leg", "amputation", "may", "have", "characteristic", "pathophysiologic", "and", "clinical", "features", ".", "A", "knowledge", "of", "these", "factors", "may", "lead", "to", "earlier", "diagnosis", "and", "avoid", "immobilization", ".", "There", "ist", "no", "German", "language", "review", "of", "this", "aspect", "of", "dermatology", ".", "After", "providing", "an", "overview", "of", "the", "problem", ",", "including", "a", "discussion", "of", "prostheses", ",", "we", "review", "the", "following", "problems", ":", "mechanically", "induced", "blisters", ",", "follicular", "keratoses", ",", "epidermoid", "cysts", ",", "stump", "edema", "syndrome", ",", "acroangiodermatitis", "(", "pseudo", "-", "kaposi", "sarcoma", ")", "and", "verrucous", "hyperplasia", "." ]	[ "umlsterm" ]
Dermatologic disorders is an umlsterm, stump is an umlsterm, patients is an umlsterm, leg is an umlsterm, amputation is an umlsterm, knowledge is an umlsterm, diagnosis is an umlsterm, immobilization is an umlsterm, language is an umlsterm, review is an umlsterm, dermatology is an umlsterm, prostheses is an umlsterm, blisters is an umlsterm, keratoses is an umlsterm, epidermoid cysts is an umlsterm, stump is an umlsterm, edema is an umlsterm, syndrome is an umlsterm, sarcoma is an umlsterm, hyperplasia is an umlsterm	DerHautarzt.60470493.eng.abstr_task1	Sentence: Dermatologic disorders of the stump in patients with a leg amputation may have characteristic pathophysiologic and clinical features . A knowledge of these factors may lead to earlier diagnosis and avoid immobilization . There ist no German language review of this aspect of dermatology . After providing an overview of the problem , including a discussion of prostheses , we review the following problems : mechanically induced blisters , follicular keratoses , epidermoid cysts , stump edema syndrome , acroangiodermatitis ( pseudo-kaposi sarcoma ) and verrucous hyperplasia . Instructions: please typing these entity words according to sentence: Dermatologic disorders, stump, patients, leg, amputation, knowledge, diagnosis, immobilization, language, review, dermatology, prostheses, blisters, keratoses, epidermoid cysts, stump, edema, syndrome, sarcoma, hyperplasia Options: umlsterm	[ "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O" ]	Dermatologic disorders of the stump in patients with a leg amputation may have characteristic pathophysiologic and clinical features . A knowledge of these factors may lead to earlier diagnosis and avoid immobilization . There ist no German language review of this aspect of dermatology . After providing an overview of the problem , including a discussion of prostheses , we review the following problems : mechanically induced blisters , follicular keratoses , epidermoid cysts , stump edema syndrome , acroangiodermatitis ( pseudo-kaposi sarcoma ) and verrucous hyperplasia .	[ "Dermatologic", "disorders", "of", "the", "stump", "in", "patients", "with", "a", "leg", "amputation", "may", "have", "characteristic", "pathophysiologic", "and", "clinical", "features", ".", "A", "knowledge", "of", "these", "factors", "may", "lead", "to", "earlier", "diagnosis", "and", "avoid", "immobilization", ".", "There", "ist", "no", "German", "language", "review", "of", "this", "aspect", "of", "dermatology", ".", "After", "providing", "an", "overview", "of", "the", "problem", ",", "including", "a", "discussion", "of", "prostheses", ",", "we", "review", "the", "following", "problems", ":", "mechanically", "induced", "blisters", ",", "follicular", "keratoses", ",", "epidermoid", "cysts", ",", "stump", "edema", "syndrome", ",", "acroangiodermatitis", "(", "pseudo", "-", "kaposi", "sarcoma", ")", "and", "verrucous", "hyperplasia", "." ]	[ "umlsterm" ]
Dermatologic disorders, stump, patients, leg, amputation, knowledge, diagnosis, immobilization, language, review, dermatology, prostheses, blisters, keratoses, epidermoid cysts, stump, edema, syndrome, sarcoma, hyperplasia	DerHautarzt.60470493.eng.abstr_task2	Sentence: Dermatologic disorders of the stump in patients with a leg amputation may have characteristic pathophysiologic and clinical features . A knowledge of these factors may lead to earlier diagnosis and avoid immobilization . There ist no German language review of this aspect of dermatology . After providing an overview of the problem , including a discussion of prostheses , we review the following problems : mechanically induced blisters , follicular keratoses , epidermoid cysts , stump edema syndrome , acroangiodermatitis ( pseudo-kaposi sarcoma ) and verrucous hyperplasia . Instructions: please extract entity words from the input sentence	[ "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O" ]	Dermatologic disorders of the stump in patients with a leg amputation may have characteristic pathophysiologic and clinical features . A knowledge of these factors may lead to earlier diagnosis and avoid immobilization . There ist no German language review of this aspect of dermatology . After providing an overview of the problem , including a discussion of prostheses , we review the following problems : mechanically induced blisters , follicular keratoses , epidermoid cysts , stump edema syndrome , acroangiodermatitis ( pseudo-kaposi sarcoma ) and verrucous hyperplasia .	[ "Dermatologic", "disorders", "of", "the", "stump", "in", "patients", "with", "a", "leg", "amputation", "may", "have", "characteristic", "pathophysiologic", "and", "clinical", "features", ".", "A", "knowledge", "of", "these", "factors", "may", "lead", "to", "earlier", "diagnosis", "and", "avoid", "immobilization", ".", "There", "ist", "no", "German", "language", "review", "of", "this", "aspect", "of", "dermatology", ".", "After", "providing", "an", "overview", "of", "the", "problem", ",", "including", "a", "discussion", "of", "prostheses", ",", "we", "review", "the", "following", "problems", ":", "mechanically", "induced", "blisters", ",", "follicular", "keratoses", ",", "epidermoid", "cysts", ",", "stump", "edema", "syndrome", ",", "acroangiodermatitis", "(", "pseudo", "-", "kaposi", "sarcoma", ")", "and", "verrucous", "hyperplasia", "." ]	[ "umlsterm" ]
5-benzylidene thiazolidine-2,4-dione is a CHEMICAL	23537942_task0	Sentence: Anticancer activity of novel hybrid molecules containing 5-benzylidene thiazolidine-2,4-dione. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL	[ "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O" ]	Anticancer activity of novel hybrid molecules containing 5-benzylidene thiazolidine-2,4-dione.	[ "Anticancer", "activity", "of", "novel", "hybrid", "molecules", "containing", "5-benzylidene", "thiazolidine-2,4-dione", "." ]	[ "CHEMICAL", "GENE-Y", "GENE-N" ]
5-benzylidene thiazolidine-2,4-dione is a CHEMICAL	23537942_task1	Sentence: Anticancer activity of novel hybrid molecules containing 5-benzylidene thiazolidine-2,4-dione. Instructions: please typing these entity words according to sentence: 5-benzylidene thiazolidine-2,4-dione Options: CHEMICAL	[ "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O" ]	Anticancer activity of novel hybrid molecules containing 5-benzylidene thiazolidine-2,4-dione.	[ "Anticancer", "activity", "of", "novel", "hybrid", "molecules", "containing", "5-benzylidene", "thiazolidine-2,4-dione", "." ]	[ "CHEMICAL", "GENE-Y", "GENE-N" ]
5-benzylidene thiazolidine-2,4-dione	23537942_task2	Sentence: Anticancer activity of novel hybrid molecules containing 5-benzylidene thiazolidine-2,4-dione. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O" ]	Anticancer activity of novel hybrid molecules containing 5-benzylidene thiazolidine-2,4-dione.	[ "Anticancer", "activity", "of", "novel", "hybrid", "molecules", "containing", "5-benzylidene", "thiazolidine-2,4-dione", "." ]	[ "CHEMICAL", "GENE-Y", "GENE-N" ]
inosine-5'-monophosphate dehydrogenase type II is a protein_molecule, human T cells is a cell_type, 5 ' palindromic octamer sequence is a DNA_domain_or_region	58976_task0	Sentence: Regulation of inosine-5'-monophosphate dehydrogenase type II gene expression in human T cells. Role for a novel 5' palindromic octamer sequence. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: cell_type, DNA_domain_or_region, protein_molecule	[ "O", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "O", "B-cell_type", "I-cell_type", "I-cell_type", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O" ]	Regulation of inosine-5'-monophosphate dehydrogenase type II gene expression in human T cells. Role for a novel 5' palindromic octamer sequence.	[ "Regulation", "of", "inosine-5'-monophosphate", "dehydrogenase", "type", "II", "gene", "expression", "in", "human", "T", "cells", ".", "Role", "for", "a", "novel", "5", "'", "palindromic", "octamer", "sequence", "." ]	[ "protein_molecule", "cell_type", "other_name", "DNA_domain_or_region", "protein_family_or_group", "nucleotide", "(AND DNA_domain_or_region DNA_domain_or_region)", "DNA_family_or_group", "" ]
inosine-5'-monophosphate dehydrogenase type II is a protein_molecule, human T cells is a cell_type, 5 ' palindromic octamer sequence is a DNA_domain_or_region	58976_task1	Sentence: Regulation of inosine-5'-monophosphate dehydrogenase type II gene expression in human T cells. Role for a novel 5' palindromic octamer sequence. Instructions: please typing these entity words according to sentence: inosine-5'-monophosphate dehydrogenase type II, human T cells, 5 ' palindromic octamer sequence Options: cell_type, DNA_domain_or_region, protein_molecule	[ "O", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "O", "B-cell_type", "I-cell_type", "I-cell_type", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O" ]	Regulation of inosine-5'-monophosphate dehydrogenase type II gene expression in human T cells. Role for a novel 5' palindromic octamer sequence.	[ "Regulation", "of", "inosine-5'-monophosphate", "dehydrogenase", "type", "II", "gene", "expression", "in", "human", "T", "cells", ".", "Role", "for", "a", "novel", "5", "'", "palindromic", "octamer", "sequence", "." ]	[ "protein_molecule", "cell_type", "other_name", "DNA_domain_or_region", "protein_family_or_group", "nucleotide", "(AND DNA_domain_or_region DNA_domain_or_region)", "DNA_family_or_group", "" ]
inosine-5'-monophosphate dehydrogenase type II, human T cells, 5 ' palindromic octamer sequence	58976_task2	Sentence: Regulation of inosine-5'-monophosphate dehydrogenase type II gene expression in human T cells. Role for a novel 5' palindromic octamer sequence. Instructions: please extract entity words from the input sentence	[ "O", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "O", "B-cell_type", "I-cell_type", "I-cell_type", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O" ]	Regulation of inosine-5'-monophosphate dehydrogenase type II gene expression in human T cells. Role for a novel 5' palindromic octamer sequence.	[ "Regulation", "of", "inosine-5'-monophosphate", "dehydrogenase", "type", "II", "gene", "expression", "in", "human", "T", "cells", ".", "Role", "for", "a", "novel", "5", "'", "palindromic", "octamer", "sequence", "." ]	[ "protein_molecule", "cell_type", "other_name", "DNA_domain_or_region", "protein_family_or_group", "nucleotide", "(AND DNA_domain_or_region DNA_domain_or_region)", "DNA_family_or_group", "" ]
Clinical/ Histological/ cytological/ Imaging examination is a Scope, Oral / Oropharynx is a Scope, Squamous - cell carcinoma is a Condition, Tongue , buccal mucosa , mouth floor , hard palate , Molar area is a Scope, depth of invasion is a Measurement, > 4 mm is a Value, preoperative assessment is a Procedure, clinical stage I / II is a Scope, T1 - 2 N0 M0 is a Scope, surgical resection is a Procedure, Normal is a Value, bone marrow reserve function is a Measurement, normal is a Value, kidney function is a Measurement	NCT03017053_inc_task0	Sentence: Ability to understand and the willingness to sign a written informed consent document Age= 18 and= 75 years Clinical/ Histological/ cytological/ Imaging examination proven Oral/Oropharynx Squamous-cell carcinoma (Tongue, buccal mucosa, mouth floor, hard palate, Molar area), the depth of invasion > 4mm in preoperative assessment In line with clinical stage I / II stage (T1-2 N0 M0; AJCC 2010) and receiving surgical resection KPS= 70 Normal bone marrow reserve function and normal liver, kidney function Expected survival period= 6 months Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Condition, Value, Procedure, Scope, Measurement	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Scope", "I-Scope", "I-Scope", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "B-Procedure", "I-Procedure", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "O", "O", "B-Value", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "O", "B-Value", "O", "O", "B-Measurement", "I-Measurement", "O", "O", "O", "O", "O", "O", "O" ]	Ability to understand and the willingness to sign a written informed consent document Age= 18 and= 75 years Clinical/ Histological/ cytological/ Imaging examination proven Oral/Oropharynx Squamous-cell carcinoma (Tongue, buccal mucosa, mouth floor, hard palate, Molar area), the depth of invasion > 4mm in preoperative assessment In line with clinical stage I / II stage (T1-2 N0 M0; AJCC 2010) and receiving surgical resection KPS= 70 Normal bone marrow reserve function and normal liver, kidney function Expected survival period= 6 months	[ "Ability", "to", "understand", "and", "the", "willingness", "to", "sign", "a", "written", "informed", "consent", "document", "\n", "Age=", "18", "and=", "75", "years", "\n", "Clinical/", "Histological/", "cytological/", "Imaging", "examination", "proven", "Oral", "/", "Oropharynx", "Squamous", "-", "cell", "carcinoma", "(", "Tongue", ",", "buccal", "mucosa", ",", "mouth", "floor", ",", "hard", "palate", ",", "Molar", "area", ")", ",", "the", "depth", "of", "invasion", ">", "4", "mm", "in", "preoperative", "assessment", "\n", "In", "line", "with", "clinical", "stage", "I", "/", "II", "stage", "(", "T1", "-", "2", "N0", "M0", ";", "AJCC", "2010", ")", "and", "receiving", "surgical", "resection", "\n", "KPS=", "70", "\n", "Normal", "bone", "marrow", "reserve", "function", "and", "normal", "liver", ",", "kidney", "function", "\n", "Expected", "survival", "period=", "6", "months", "\n" ]	[ "Scope", "Measurement", "Observation", "Condition", "Procedure", "Value", "Qualifier", "Person" ]
Clinical/ Histological/ cytological/ Imaging examination is a Scope, Oral / Oropharynx is a Scope, Squamous - cell carcinoma is a Condition, Tongue , buccal mucosa , mouth floor , hard palate , Molar area is a Scope, depth of invasion is a Measurement, > 4 mm is a Value, preoperative assessment is a Procedure, clinical stage I / II is a Scope, T1 - 2 N0 M0 is a Scope, surgical resection is a Procedure, Normal is a Value, bone marrow reserve function is a Measurement, normal is a Value, kidney function is a Measurement	NCT03017053_inc_task1	Sentence: Ability to understand and the willingness to sign a written informed consent document Age= 18 and= 75 years Clinical/ Histological/ cytological/ Imaging examination proven Oral/Oropharynx Squamous-cell carcinoma (Tongue, buccal mucosa, mouth floor, hard palate, Molar area), the depth of invasion > 4mm in preoperative assessment In line with clinical stage I / II stage (T1-2 N0 M0; AJCC 2010) and receiving surgical resection KPS= 70 Normal bone marrow reserve function and normal liver, kidney function Expected survival period= 6 months Instructions: please typing these entity words according to sentence: Clinical/ Histological/ cytological/ Imaging examination, Oral / Oropharynx, Squamous - cell carcinoma, Tongue , buccal mucosa , mouth floor , hard palate , Molar area, depth of invasion, > 4 mm, preoperative assessment, clinical stage I / II, T1 - 2 N0 M0, surgical resection, Normal, bone marrow reserve function, normal, kidney function Options: Condition, Value, Procedure, Scope, Measurement	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Scope", "I-Scope", "I-Scope", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "B-Procedure", "I-Procedure", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "O", "O", "B-Value", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "O", "B-Value", "O", "O", "B-Measurement", "I-Measurement", "O", "O", "O", "O", "O", "O", "O" ]	Ability to understand and the willingness to sign a written informed consent document Age= 18 and= 75 years Clinical/ Histological/ cytological/ Imaging examination proven Oral/Oropharynx Squamous-cell carcinoma (Tongue, buccal mucosa, mouth floor, hard palate, Molar area), the depth of invasion > 4mm in preoperative assessment In line with clinical stage I / II stage (T1-2 N0 M0; AJCC 2010) and receiving surgical resection KPS= 70 Normal bone marrow reserve function and normal liver, kidney function Expected survival period= 6 months	[ "Ability", "to", "understand", "and", "the", "willingness", "to", "sign", "a", "written", "informed", "consent", "document", "\n", "Age=", "18", "and=", "75", "years", "\n", "Clinical/", "Histological/", "cytological/", "Imaging", "examination", "proven", "Oral", "/", "Oropharynx", "Squamous", "-", "cell", "carcinoma", "(", "Tongue", ",", "buccal", "mucosa", ",", "mouth", "floor", ",", "hard", "palate", ",", "Molar", "area", ")", ",", "the", "depth", "of", "invasion", ">", "4", "mm", "in", "preoperative", "assessment", "\n", "In", "line", "with", "clinical", "stage", "I", "/", "II", "stage", "(", "T1", "-", "2", "N0", "M0", ";", "AJCC", "2010", ")", "and", "receiving", "surgical", "resection", "\n", "KPS=", "70", "\n", "Normal", "bone", "marrow", "reserve", "function", "and", "normal", "liver", ",", "kidney", "function", "\n", "Expected", "survival", "period=", "6", "months", "\n" ]	[ "Scope", "Measurement", "Observation", "Condition", "Procedure", "Value", "Qualifier", "Person" ]
Clinical/ Histological/ cytological/ Imaging examination, Oral / Oropharynx, Squamous - cell carcinoma, Tongue , buccal mucosa , mouth floor , hard palate , Molar area, depth of invasion, > 4 mm, preoperative assessment, clinical stage I / II, T1 - 2 N0 M0, surgical resection, Normal, bone marrow reserve function, normal, kidney function	NCT03017053_inc_task2	Sentence: Ability to understand and the willingness to sign a written informed consent document Age= 18 and= 75 years Clinical/ Histological/ cytological/ Imaging examination proven Oral/Oropharynx Squamous-cell carcinoma (Tongue, buccal mucosa, mouth floor, hard palate, Molar area), the depth of invasion > 4mm in preoperative assessment In line with clinical stage I / II stage (T1-2 N0 M0; AJCC 2010) and receiving surgical resection KPS= 70 Normal bone marrow reserve function and normal liver, kidney function Expected survival period= 6 months Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Scope", "I-Scope", "I-Scope", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "B-Procedure", "I-Procedure", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "O", "O", "B-Value", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "O", "B-Value", "O", "O", "B-Measurement", "I-Measurement", "O", "O", "O", "O", "O", "O", "O" ]	Ability to understand and the willingness to sign a written informed consent document Age= 18 and= 75 years Clinical/ Histological/ cytological/ Imaging examination proven Oral/Oropharynx Squamous-cell carcinoma (Tongue, buccal mucosa, mouth floor, hard palate, Molar area), the depth of invasion > 4mm in preoperative assessment In line with clinical stage I / II stage (T1-2 N0 M0; AJCC 2010) and receiving surgical resection KPS= 70 Normal bone marrow reserve function and normal liver, kidney function Expected survival period= 6 months	[ "Ability", "to", "understand", "and", "the", "willingness", "to", "sign", "a", "written", "informed", "consent", "document", "\n", "Age=", "18", "and=", "75", "years", "\n", "Clinical/", "Histological/", "cytological/", "Imaging", "examination", "proven", "Oral", "/", "Oropharynx", "Squamous", "-", "cell", "carcinoma", "(", "Tongue", ",", "buccal", "mucosa", ",", "mouth", "floor", ",", "hard", "palate", ",", "Molar", "area", ")", ",", "the", "depth", "of", "invasion", ">", "4", "mm", "in", "preoperative", "assessment", "\n", "In", "line", "with", "clinical", "stage", "I", "/", "II", "stage", "(", "T1", "-", "2", "N0", "M0", ";", "AJCC", "2010", ")", "and", "receiving", "surgical", "resection", "\n", "KPS=", "70", "\n", "Normal", "bone", "marrow", "reserve", "function", "and", "normal", "liver", ",", "kidney", "function", "\n", "Expected", "survival", "period=", "6", "months", "\n" ]	[ "Scope", "Measurement", "Observation", "Condition", "Procedure", "Value", "Qualifier", "Person" ]
Analyse is an umlsterm, Anaesthesieabteilung is an umlsterm, Krankenhausebene is an umlsterm, Anaesthesieabteilungen is an umlsterm	DerAnaesthesist.8047s087.ger.abstr_task0	Sentence: In dem vorliegenden Artikel werden die Kosten von Sevofluran im perioperativen Umfeld dargestellt . Die Analyse der Kosten fuer eine Anaesthesieabteilung im Vergleich zu den operativen Disziplinen auf Krankenhausebene zeigt i.d.R. einen proportionalen Anteil gemaess der Anzahl der verschiedenen Disziplinen , d.h. Anaesthesieabteilungen sind keine ueberproportional kostenintensiven Abteilungen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]	In dem vorliegenden Artikel werden die Kosten von Sevofluran im perioperativen Umfeld dargestellt . Die Analyse der Kosten fuer eine Anaesthesieabteilung im Vergleich zu den operativen Disziplinen auf Krankenhausebene zeigt i.d.R. einen proportionalen Anteil gemaess der Anzahl der verschiedenen Disziplinen , d.h. Anaesthesieabteilungen sind keine ueberproportional kostenintensiven Abteilungen .	[ "In", "dem", "vorliegenden", "Artikel", "werden", "die", "Kosten", "von", "Sevofluran", "im", "perioperativen", "Umfeld", "dargestellt", ".", "Die", "Analyse", "der", "Kosten", "fuer", "eine", "Anaesthesieabteilung", "im", "Vergleich", "zu", "den", "operativen", "Disziplinen", "auf", "Krankenhausebene", "zeigt", "i.d", ".", "R.", "einen", "proportionalen", "Anteil", "gemaess", "der", "Anzahl", "der", "verschiedenen", "Disziplinen", ",", "d.h", ".", "Anaesthesieabteilungen", "sind", "keine", "ueberproportional", "kostenintensiven", "Abteilungen", "." ]	[ "umlsterm" ]
Analyse is an umlsterm, Anaesthesieabteilung is an umlsterm, Krankenhausebene is an umlsterm, Anaesthesieabteilungen is an umlsterm	DerAnaesthesist.8047s087.ger.abstr_task1	Sentence: In dem vorliegenden Artikel werden die Kosten von Sevofluran im perioperativen Umfeld dargestellt . Die Analyse der Kosten fuer eine Anaesthesieabteilung im Vergleich zu den operativen Disziplinen auf Krankenhausebene zeigt i.d.R. einen proportionalen Anteil gemaess der Anzahl der verschiedenen Disziplinen , d.h. Anaesthesieabteilungen sind keine ueberproportional kostenintensiven Abteilungen . Instructions: please typing these entity words according to sentence: Analyse, Anaesthesieabteilung, Krankenhausebene, Anaesthesieabteilungen Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]	In dem vorliegenden Artikel werden die Kosten von Sevofluran im perioperativen Umfeld dargestellt . Die Analyse der Kosten fuer eine Anaesthesieabteilung im Vergleich zu den operativen Disziplinen auf Krankenhausebene zeigt i.d.R. einen proportionalen Anteil gemaess der Anzahl der verschiedenen Disziplinen , d.h. Anaesthesieabteilungen sind keine ueberproportional kostenintensiven Abteilungen .	[ "In", "dem", "vorliegenden", "Artikel", "werden", "die", "Kosten", "von", "Sevofluran", "im", "perioperativen", "Umfeld", "dargestellt", ".", "Die", "Analyse", "der", "Kosten", "fuer", "eine", "Anaesthesieabteilung", "im", "Vergleich", "zu", "den", "operativen", "Disziplinen", "auf", "Krankenhausebene", "zeigt", "i.d", ".", "R.", "einen", "proportionalen", "Anteil", "gemaess", "der", "Anzahl", "der", "verschiedenen", "Disziplinen", ",", "d.h", ".", "Anaesthesieabteilungen", "sind", "keine", "ueberproportional", "kostenintensiven", "Abteilungen", "." ]	[ "umlsterm" ]
Analyse, Anaesthesieabteilung, Krankenhausebene, Anaesthesieabteilungen	DerAnaesthesist.8047s087.ger.abstr_task2	Sentence: In dem vorliegenden Artikel werden die Kosten von Sevofluran im perioperativen Umfeld dargestellt . Die Analyse der Kosten fuer eine Anaesthesieabteilung im Vergleich zu den operativen Disziplinen auf Krankenhausebene zeigt i.d.R. einen proportionalen Anteil gemaess der Anzahl der verschiedenen Disziplinen , d.h. Anaesthesieabteilungen sind keine ueberproportional kostenintensiven Abteilungen . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]	In dem vorliegenden Artikel werden die Kosten von Sevofluran im perioperativen Umfeld dargestellt . Die Analyse der Kosten fuer eine Anaesthesieabteilung im Vergleich zu den operativen Disziplinen auf Krankenhausebene zeigt i.d.R. einen proportionalen Anteil gemaess der Anzahl der verschiedenen Disziplinen , d.h. Anaesthesieabteilungen sind keine ueberproportional kostenintensiven Abteilungen .	[ "In", "dem", "vorliegenden", "Artikel", "werden", "die", "Kosten", "von", "Sevofluran", "im", "perioperativen", "Umfeld", "dargestellt", ".", "Die", "Analyse", "der", "Kosten", "fuer", "eine", "Anaesthesieabteilung", "im", "Vergleich", "zu", "den", "operativen", "Disziplinen", "auf", "Krankenhausebene", "zeigt", "i.d", ".", "R.", "einen", "proportionalen", "Anteil", "gemaess", "der", "Anzahl", "der", "verschiedenen", "Disziplinen", ",", "d.h", ".", "Anaesthesieabteilungen", "sind", "keine", "ueberproportional", "kostenintensiven", "Abteilungen", "." ]	[ "umlsterm" ]
Kinase is a GENE-N, CK2 is a GENE-N	23210774_task0	Sentence: Kinase CK2 inhibition: an update. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N	[ "B-GENE-N", "B-GENE-N", "O", "O", "O", "O", "O" ]	Kinase CK2 inhibition: an update.	[ "Kinase", "CK2", "inhibition", ":", "an", "update", "." ]	[ "GENE-N", "CHEMICAL" ]
Kinase is a GENE-N, CK2 is a GENE-N	23210774_task1	Sentence: Kinase CK2 inhibition: an update. Instructions: please typing these entity words according to sentence: Kinase, CK2 Options: GENE-N	[ "B-GENE-N", "B-GENE-N", "O", "O", "O", "O", "O" ]	Kinase CK2 inhibition: an update.	[ "Kinase", "CK2", "inhibition", ":", "an", "update", "." ]	[ "GENE-N", "CHEMICAL" ]
Kinase, CK2	23210774_task2	Sentence: Kinase CK2 inhibition: an update. Instructions: please extract entity words from the input sentence	[ "B-GENE-N", "B-GENE-N", "O", "O", "O", "O", "O" ]	Kinase CK2 inhibition: an update.	[ "Kinase", "CK2", "inhibition", ":", "an", "update", "." ]	[ "GENE-N", "CHEMICAL" ]
patients is an umlsterm, radius fractures is an umlsterm, assistance is an umlsterm, patients is an umlsterm, ligaments is an umlsterm, I - tear is an umlsterm, patient is an umlsterm, patients is an umlsterm, arthrodesis is an umlsterm, patients is an umlsterm, Clinical examination is an umlsterm, range of motion is an umlsterm, tests is an umlsterm, questionnaire is an umlsterm, pain is an umlsterm, ability is an umlsterm, Objective is an umlsterm, grip is an umlsterm, wrist is an umlsterm, evaluation is an umlsterm, stress is an umlsterm, patients is an umlsterm, questionnaire is an umlsterm, patients is an umlsterm	Arthroskopie.90120313.eng.abstr_task0	Sentence: Since 1993 , 30 patients with acute intraarticular distal radius fractures have been treated under arthroscopic assistance . In 12 patients ( 40% ) concomitant lesions of the intrinsic scapholunate ligaments were diagnosed . According to Geissler we found grade I-tear in one patient , grade II in three , grade III in six and grade IV in two patients . The eight individuals with grade III-and IV-lesions additionally revealed marked instablity intraoperatively . Therefore , operative stabilization was subsequently performed by temporary scapholunate and scaphocapitate arthrodesis . Seven patients out of this group ( 87.5% ) were followed up clinically and radiologically 3 years postoperatively , on average . Clinical examination included range of motion tests and a subjective questionnaire concerning pain and working ability . Objective grip strength was measured using a Jamar tester and compared to the contralateral wrist . Radiological evaluation consisted of the posteroanterior and lateral view as well as stress views in radial and ulnar deviation . Data were evaluated by the Jakim and Cooney scoring system as well as the demerit point system by Gartland and Werley as modified by Sarmiento et al. According to Gartland , 100% of our patients showed an excellent result ; these rates were 86% using the Jakim score and 60% using the Cooney scoring system . According to the subjective questionnaire all of the patients revealed an excellent or good result . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]	Since 1993 , 30 patients with acute intraarticular distal radius fractures have been treated under arthroscopic assistance . In 12 patients ( 40% ) concomitant lesions of the intrinsic scapholunate ligaments were diagnosed . According to Geissler we found grade I-tear in one patient , grade II in three , grade III in six and grade IV in two patients . The eight individuals with grade III-and IV-lesions additionally revealed marked instablity intraoperatively . Therefore , operative stabilization was subsequently performed by temporary scapholunate and scaphocapitate arthrodesis . Seven patients out of this group ( 87.5% ) were followed up clinically and radiologically 3 years postoperatively , on average . Clinical examination included range of motion tests and a subjective questionnaire concerning pain and working ability . Objective grip strength was measured using a Jamar tester and compared to the contralateral wrist . Radiological evaluation consisted of the posteroanterior and lateral view as well as stress views in radial and ulnar deviation . Data were evaluated by the Jakim and Cooney scoring system as well as the demerit point system by Gartland and Werley as modified by Sarmiento et al. According to Gartland , 100% of our patients showed an excellent result ; these rates were 86% using the Jakim score and 60% using the Cooney scoring system . According to the subjective questionnaire all of the patients revealed an excellent or good result .	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patients is an umlsterm, radius fractures is an umlsterm, assistance is an umlsterm, patients is an umlsterm, ligaments is an umlsterm, I - tear is an umlsterm, patient is an umlsterm, patients is an umlsterm, arthrodesis is an umlsterm, patients is an umlsterm, Clinical examination is an umlsterm, range of motion is an umlsterm, tests is an umlsterm, questionnaire is an umlsterm, pain is an umlsterm, ability is an umlsterm, Objective is an umlsterm, grip is an umlsterm, wrist is an umlsterm, evaluation is an umlsterm, stress is an umlsterm, patients is an umlsterm, questionnaire is an umlsterm, patients is an umlsterm	Arthroskopie.90120313.eng.abstr_task1	Sentence: Since 1993 , 30 patients with acute intraarticular distal radius fractures have been treated under arthroscopic assistance . In 12 patients ( 40% ) concomitant lesions of the intrinsic scapholunate ligaments were diagnosed . According to Geissler we found grade I-tear in one patient , grade II in three , grade III in six and grade IV in two patients . The eight individuals with grade III-and IV-lesions additionally revealed marked instablity intraoperatively . Therefore , operative stabilization was subsequently performed by temporary scapholunate and scaphocapitate arthrodesis . Seven patients out of this group ( 87.5% ) were followed up clinically and radiologically 3 years postoperatively , on average . Clinical examination included range of motion tests and a subjective questionnaire concerning pain and working ability . Objective grip strength was measured using a Jamar tester and compared to the contralateral wrist . Radiological evaluation consisted of the posteroanterior and lateral view as well as stress views in radial and ulnar deviation . Data were evaluated by the Jakim and Cooney scoring system as well as the demerit point system by Gartland and Werley as modified by Sarmiento et al. According to Gartland , 100% of our patients showed an excellent result ; these rates were 86% using the Jakim score and 60% using the Cooney scoring system . According to the subjective questionnaire all of the patients revealed an excellent or good result . Instructions: please typing these entity words according to sentence: patients, radius fractures, assistance, patients, ligaments, I - tear, patient, patients, arthrodesis, patients, Clinical examination, range of motion, tests, questionnaire, pain, ability, Objective, grip, wrist, evaluation, stress, patients, questionnaire, patients Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]	Since 1993 , 30 patients with acute intraarticular distal radius fractures have been treated under arthroscopic assistance . In 12 patients ( 40% ) concomitant lesions of the intrinsic scapholunate ligaments were diagnosed . According to Geissler we found grade I-tear in one patient , grade II in three , grade III in six and grade IV in two patients . The eight individuals with grade III-and IV-lesions additionally revealed marked instablity intraoperatively . Therefore , operative stabilization was subsequently performed by temporary scapholunate and scaphocapitate arthrodesis . Seven patients out of this group ( 87.5% ) were followed up clinically and radiologically 3 years postoperatively , on average . Clinical examination included range of motion tests and a subjective questionnaire concerning pain and working ability . Objective grip strength was measured using a Jamar tester and compared to the contralateral wrist . Radiological evaluation consisted of the posteroanterior and lateral view as well as stress views in radial and ulnar deviation . Data were evaluated by the Jakim and Cooney scoring system as well as the demerit point system by Gartland and Werley as modified by Sarmiento et al. According to Gartland , 100% of our patients showed an excellent result ; these rates were 86% using the Jakim score and 60% using the Cooney scoring system . According to the subjective questionnaire all of the patients revealed an excellent or good result .	[ "Since", "1993", ",", "30", "patients", "with", "acute", "intraarticular", "distal", "radius", "fractures", "have", "been", "treated", "under", "arthroscopic", "assistance", ".", "In", "12", "patients", "(", "40", "%", ")", "concomitant", "lesions", "of", "the", "intrinsic", "scapholunate", "ligaments", "were", "diagnosed", ".", "According", "to", "Geissler", "we", "found", "grade", "I", "-", "tear", "in", "one", "patient", ",", "grade", "II", "in", "three", ",", "grade", "III", "in", "six", "and", "grade", "IV", "in", "two", "patients", ".", "The", "eight", "individuals", "with", "grade", "III", "-", "and", "IV", "-", "lesions", "additionally", "revealed", "marked", "instablity", "intraoperatively", ".", "Therefore", ",", "operative", "stabilization", "was", "subsequently", "performed", "by", "temporary", "scapholunate", "and", "scaphocapitate", "arthrodesis", ".", "Seven", "patients", "out", "of", "this", "group", "(", "87.5", "%", ")", "were", "followed", "up", "clinically", "and", "radiologically", "3", "years", "postoperatively", ",", "on", "average", ".", "Clinical", "examination", "included", "range", "of", "motion", "tests", "and", "a", "subjective", "questionnaire", "concerning", "pain", "and", "working", "ability", ".", "Objective", "grip", "strength", "was", "measured", "using", "a", "Jamar", "tester", "and", "compared", "to", "the", "contralateral", "wrist", ".", "Radiological", "evaluation", "consisted", "of", "the", "posteroanterior", "and", "lateral", "view", "as", "well", "as", "stress", "views", "in", "radial", "and", "ulnar", "deviation", ".", "Data", "were", "evaluated", "by", "the", "Jakim", "and", "Cooney", "scoring", "system", "as", "well", "as", "the", "demerit", "point", "system", "by", "Gartland", "and", "Werley", "as", "modified", "by", "Sarmiento", "et", "al", ".", "According", "to", "Gartland", ",", "100", "%", "of", "our", "patients", "showed", "an", "excellent", "result", ";", "these", "rates", "were", "86", "%", "using", "the", "Jakim", "score", "and", "60", "%", "using", "the", "Cooney", "scoring", "system", ".", "According", "to", "the", "subjective", "questionnaire", "all", "of", "the", "patients", "revealed", "an", "excellent", "or", "good", "result", "." ]	[ "umlsterm" ]
patients, radius fractures, assistance, patients, ligaments, I - tear, patient, patients, arthrodesis, patients, Clinical examination, range of motion, tests, questionnaire, pain, ability, Objective, grip, wrist, evaluation, stress, patients, questionnaire, patients	Arthroskopie.90120313.eng.abstr_task2	Sentence: Since 1993 , 30 patients with acute intraarticular distal radius fractures have been treated under arthroscopic assistance . In 12 patients ( 40% ) concomitant lesions of the intrinsic scapholunate ligaments were diagnosed . According to Geissler we found grade I-tear in one patient , grade II in three , grade III in six and grade IV in two patients . The eight individuals with grade III-and IV-lesions additionally revealed marked instablity intraoperatively . Therefore , operative stabilization was subsequently performed by temporary scapholunate and scaphocapitate arthrodesis . Seven patients out of this group ( 87.5% ) were followed up clinically and radiologically 3 years postoperatively , on average . Clinical examination included range of motion tests and a subjective questionnaire concerning pain and working ability . Objective grip strength was measured using a Jamar tester and compared to the contralateral wrist . Radiological evaluation consisted of the posteroanterior and lateral view as well as stress views in radial and ulnar deviation . Data were evaluated by the Jakim and Cooney scoring system as well as the demerit point system by Gartland and Werley as modified by Sarmiento et al. According to Gartland , 100% of our patients showed an excellent result ; these rates were 86% using the Jakim score and 60% using the Cooney scoring system . According to the subjective questionnaire all of the patients revealed an excellent or good result . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O" ]	Since 1993 , 30 patients with acute intraarticular distal radius fractures have been treated under arthroscopic assistance . In 12 patients ( 40% ) concomitant lesions of the intrinsic scapholunate ligaments were diagnosed . According to Geissler we found grade I-tear in one patient , grade II in three , grade III in six and grade IV in two patients . The eight individuals with grade III-and IV-lesions additionally revealed marked instablity intraoperatively . Therefore , operative stabilization was subsequently performed by temporary scapholunate and scaphocapitate arthrodesis . Seven patients out of this group ( 87.5% ) were followed up clinically and radiologically 3 years postoperatively , on average . Clinical examination included range of motion tests and a subjective questionnaire concerning pain and working ability . Objective grip strength was measured using a Jamar tester and compared to the contralateral wrist . Radiological evaluation consisted of the posteroanterior and lateral view as well as stress views in radial and ulnar deviation . Data were evaluated by the Jakim and Cooney scoring system as well as the demerit point system by Gartland and Werley as modified by Sarmiento et al. According to Gartland , 100% of our patients showed an excellent result ; these rates were 86% using the Jakim score and 60% using the Cooney scoring system . According to the subjective questionnaire all of the patients revealed an excellent or good result .	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complication is an umlsterm, trauma is an umlsterm, surgery is an umlsterm, connective tissue is an umlsterm, etiology is an umlsterm, pathogenesis is an umlsterm, fibroblasts is an umlsterm, proteins is an umlsterm, lung fibrosis is an umlsterm, fibromatoses is an umlsterm, collagen type VI is an umlsterm, tissue is an umlsterm, patients is an umlsterm, age is an umlsterm, knee joint is an umlsterm, ligament is an umlsterm, injury is an umlsterm, trauma is an umlsterm, Tissue is an umlsterm, fat is an umlsterm, connective tissue is an umlsterm, All is an umlsterm, collagen is an umlsterm, immunoperoxidase is an umlsterm, method is an umlsterm, light is an umlsterm, visualization is an umlsterm, Histologic is an umlsterm, analysis is an umlsterm, patients is an umlsterm, hyperplasia is an umlsterm, cell is an umlsterm, synovial tissue is an umlsterm, knee joints is an umlsterm, pathology is an umlsterm, proteins is an umlsterm, Type VI collagen is an umlsterm, capillary is an umlsterm, Type III collagen is an umlsterm, distribution is an umlsterm, tissue is an umlsterm, collagen type VI is an umlsterm, Collagen type VI is an umlsterm, role is an umlsterm, homeostasis is an umlsterm, element is an umlsterm, collagen is an umlsterm, cell is an umlsterm, binding is an umlsterm	DerUnfallchirurg.01030640.eng.abstr_task0	Sentence: Arthrofibrosis is a disabling complication after trauma and surgery due to massive connective tissue proliferation . The etiology and pathogenesis have never been fully understood . A strong immune response may lead to activation and proliferation of fibroblasts with excessive and disordered deposition of matrix proteins . In similar pathological conditions , like lung fibrosis or superficial fibromatoses with fibrotic transformation an increased expression of collagen type VI has been reported . We investigated fibrotic tissue samples taken from 18 patients ( average age : 32,7 years ) , who underwent arthrolysis of the knee joint because of symptomatic arthrofibrosis following ligament injury . The mean interval between trauma and arthrolysis was 13,8 months ( range 4-50 months ) . Tissue samples were taken from the infrapatellar fat pad and intercondylar connective tissue . All samples were stained with HE . The expression of type III and VI collagen was studied immunohistochemically using an immunoperoxidase method for light microscopic visualization . Histologic analysis from patients with arthrofibrosis showed a synovial hyperplasia with cell infiltration and vascular proliferation compared to synovial tissue samples from knee joints without any detectable pathology . Subsynovial an increased deposition of matrix proteins was visible . Type VI collagen was widely distributed as a network subsynovial and around capillary walls . Type III collagen showed a diffuse distribution . Arthrofibrotic tissue is , similar to pathological conditions with fibrotic transformation characterized by an increased expression of collagen type VI . Collagen type VI may play an important role in matrix homeostasis . It serves as an anchoring element between collagen fibers and as a cell binding structure . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O" ]	Arthrofibrosis is a disabling complication after trauma and surgery due to massive connective tissue proliferation . The etiology and pathogenesis have never been fully understood . A strong immune response may lead to activation and proliferation of fibroblasts with excessive and disordered deposition of matrix proteins . In similar pathological conditions , like lung fibrosis or superficial fibromatoses with fibrotic transformation an increased expression of collagen type VI has been reported . We investigated fibrotic tissue samples taken from 18 patients ( average age : 32,7 years ) , who underwent arthrolysis of the knee joint because of symptomatic arthrofibrosis following ligament injury . The mean interval between trauma and arthrolysis was 13,8 months ( range 4-50 months ) . Tissue samples were taken from the infrapatellar fat pad and intercondylar connective tissue . All samples were stained with HE . The expression of type III and VI collagen was studied immunohistochemically using an immunoperoxidase method for light microscopic visualization . Histologic analysis from patients with arthrofibrosis showed a synovial hyperplasia with cell infiltration and vascular proliferation compared to synovial tissue samples from knee joints without any detectable pathology . Subsynovial an increased deposition of matrix proteins was visible . Type VI collagen was widely distributed as a network subsynovial and around capillary walls . Type III collagen showed a diffuse distribution . Arthrofibrotic tissue is , similar to pathological conditions with fibrotic transformation characterized by an increased expression of collagen type VI . Collagen type VI may play an important role in matrix homeostasis . It serves as an anchoring element between collagen fibers and as a cell binding structure .	[ "Arthrofibrosis", "is", "a", "disabling", "complication", "after", "trauma", "and", "surgery", "due", "to", "massive", "connective", "tissue", "proliferation", ".", "The", "etiology", "and", "pathogenesis", "have", "never", "been", "fully", "understood", ".", "A", "strong", "immune", "response", "may", "lead", "to", "activation", "and", "proliferation", "of", "fibroblasts", "with", "excessive", "and", "disordered", "deposition", "of", "matrix", "proteins", ".", "In", "similar", "pathological", "conditions", ",", "like", "lung", "fibrosis", "or", "superficial", "fibromatoses", "with", "fibrotic", "transformation", "an", "increased", "expression", "of", "collagen", "type", "VI", "has", "been", "reported", ".", "We", "investigated", "fibrotic", "tissue", "samples", "taken", "from", "18", "patients", "(", "average", "age", ":", "32,7", "years", ")", ",", "who", "underwent", "arthrolysis", "of", "the", "knee", "joint", "because", "of", "symptomatic", "arthrofibrosis", "following", "ligament", "injury", ".", "The", "mean", "interval", "between", "trauma", "and", "arthrolysis", "was", "13,8", "months", "(", "range", "4", "-", "50", "months", ")", ".", "Tissue", "samples", "were", "taken", "from", "the", "infrapatellar", "fat", "pad", "and", "intercondylar", "connective", "tissue", ".", "All", "samples", "were", "stained", "with", "HE", ".", "The", "expression", "of", "type", "III", "and", "VI", "collagen", "was", "studied", "immunohistochemically", "using", "an", "immunoperoxidase", "method", "for", "light", "microscopic", "visualization", ".", "Histologic", "analysis", "from", "patients", "with", "arthrofibrosis", "showed", "a", "synovial", "hyperplasia", "with", "cell", "infiltration", "and", "vascular", "proliferation", "compared", "to", "synovial", "tissue", "samples", "from", "knee", "joints", "without", "any", "detectable", "pathology", ".", "Subsynovial", "an", "increased", "deposition", "of", "matrix", "proteins", "was", "visible", ".", "Type", "VI", "collagen", "was", "widely", "distributed", "as", "a", "network", "subsynovial", "and", "around", "capillary", "walls", ".", "Type", "III", "collagen", "showed", "a", "diffuse", "distribution", ".", "Arthrofibrotic", "tissue", "is", ",", "similar", "to", "pathological", "conditions", "with", "fibrotic", "transformation", "characterized", "by", "an", "increased", "expression", "of", "collagen", "type", "VI", ".", "Collagen", "type", "VI", "may", "play", "an", "important", "role", "in", "matrix", "homeostasis", ".", "It", "serves", "as", "an", "anchoring", "element", "between", "collagen", "fibers", "and", "as", "a", "cell", "binding", "structure", "." ]	[ "umlsterm" ]
complication is an umlsterm, trauma is an umlsterm, surgery is an umlsterm, connective tissue is an umlsterm, etiology is an umlsterm, pathogenesis is an umlsterm, fibroblasts is an umlsterm, proteins is an umlsterm, lung fibrosis is an umlsterm, fibromatoses is an umlsterm, collagen type VI is an umlsterm, tissue is an umlsterm, patients is an umlsterm, age is an umlsterm, knee joint is an umlsterm, ligament is an umlsterm, injury is an umlsterm, trauma is an umlsterm, Tissue is an umlsterm, fat is an umlsterm, connective tissue is an umlsterm, All is an umlsterm, collagen is an umlsterm, immunoperoxidase is an umlsterm, method is an umlsterm, light is an umlsterm, visualization is an umlsterm, Histologic is an umlsterm, analysis is an umlsterm, patients is an umlsterm, hyperplasia is an umlsterm, cell is an umlsterm, synovial tissue is an umlsterm, knee joints is an umlsterm, pathology is an umlsterm, proteins is an umlsterm, Type VI collagen is an umlsterm, capillary is an umlsterm, Type III collagen is an umlsterm, distribution is an umlsterm, tissue is an umlsterm, collagen type VI is an umlsterm, Collagen type VI is an umlsterm, role is an umlsterm, homeostasis is an umlsterm, element is an umlsterm, collagen is an umlsterm, cell is an umlsterm, binding is an umlsterm	DerUnfallchirurg.01030640.eng.abstr_task1	Sentence: Arthrofibrosis is a disabling complication after trauma and surgery due to massive connective tissue proliferation . The etiology and pathogenesis have never been fully understood . A strong immune response may lead to activation and proliferation of fibroblasts with excessive and disordered deposition of matrix proteins . In similar pathological conditions , like lung fibrosis or superficial fibromatoses with fibrotic transformation an increased expression of collagen type VI has been reported . We investigated fibrotic tissue samples taken from 18 patients ( average age : 32,7 years ) , who underwent arthrolysis of the knee joint because of symptomatic arthrofibrosis following ligament injury . The mean interval between trauma and arthrolysis was 13,8 months ( range 4-50 months ) . Tissue samples were taken from the infrapatellar fat pad and intercondylar connective tissue . All samples were stained with HE . The expression of type III and VI collagen was studied immunohistochemically using an immunoperoxidase method for light microscopic visualization . Histologic analysis from patients with arthrofibrosis showed a synovial hyperplasia with cell infiltration and vascular proliferation compared to synovial tissue samples from knee joints without any detectable pathology . Subsynovial an increased deposition of matrix proteins was visible . Type VI collagen was widely distributed as a network subsynovial and around capillary walls . Type III collagen showed a diffuse distribution . Arthrofibrotic tissue is , similar to pathological conditions with fibrotic transformation characterized by an increased expression of collagen type VI . Collagen type VI may play an important role in matrix homeostasis . It serves as an anchoring element between collagen fibers and as a cell binding structure . Instructions: please typing these entity words according to sentence: complication, trauma, surgery, connective tissue, etiology, pathogenesis, fibroblasts, proteins, lung fibrosis, fibromatoses, collagen type VI, tissue, patients, age, knee joint, ligament, injury, trauma, Tissue, fat, connective tissue, All, collagen, immunoperoxidase, method, light, visualization, Histologic, analysis, patients, hyperplasia, cell, synovial tissue, knee joints, pathology, proteins, Type VI collagen, capillary, Type III collagen, distribution, tissue, collagen type VI, Collagen type VI, role, homeostasis, element, collagen, cell, binding Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O" ]	Arthrofibrosis is a disabling complication after trauma and surgery due to massive connective tissue proliferation . The etiology and pathogenesis have never been fully understood . A strong immune response may lead to activation and proliferation of fibroblasts with excessive and disordered deposition of matrix proteins . In similar pathological conditions , like lung fibrosis or superficial fibromatoses with fibrotic transformation an increased expression of collagen type VI has been reported . We investigated fibrotic tissue samples taken from 18 patients ( average age : 32,7 years ) , who underwent arthrolysis of the knee joint because of symptomatic arthrofibrosis following ligament injury . The mean interval between trauma and arthrolysis was 13,8 months ( range 4-50 months ) . Tissue samples were taken from the infrapatellar fat pad and intercondylar connective tissue . All samples were stained with HE . The expression of type III and VI collagen was studied immunohistochemically using an immunoperoxidase method for light microscopic visualization . Histologic analysis from patients with arthrofibrosis showed a synovial hyperplasia with cell infiltration and vascular proliferation compared to synovial tissue samples from knee joints without any detectable pathology . Subsynovial an increased deposition of matrix proteins was visible . Type VI collagen was widely distributed as a network subsynovial and around capillary walls . Type III collagen showed a diffuse distribution . Arthrofibrotic tissue is , similar to pathological conditions with fibrotic transformation characterized by an increased expression of collagen type VI . Collagen type VI may play an important role in matrix homeostasis . It serves as an anchoring element between collagen fibers and as a cell binding structure .	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complication, trauma, surgery, connective tissue, etiology, pathogenesis, fibroblasts, proteins, lung fibrosis, fibromatoses, collagen type VI, tissue, patients, age, knee joint, ligament, injury, trauma, Tissue, fat, connective tissue, All, collagen, immunoperoxidase, method, light, visualization, Histologic, analysis, patients, hyperplasia, cell, synovial tissue, knee joints, pathology, proteins, Type VI collagen, capillary, Type III collagen, distribution, tissue, collagen type VI, Collagen type VI, role, homeostasis, element, collagen, cell, binding	DerUnfallchirurg.01030640.eng.abstr_task2	Sentence: Arthrofibrosis is a disabling complication after trauma and surgery due to massive connective tissue proliferation . The etiology and pathogenesis have never been fully understood . A strong immune response may lead to activation and proliferation of fibroblasts with excessive and disordered deposition of matrix proteins . In similar pathological conditions , like lung fibrosis or superficial fibromatoses with fibrotic transformation an increased expression of collagen type VI has been reported . We investigated fibrotic tissue samples taken from 18 patients ( average age : 32,7 years ) , who underwent arthrolysis of the knee joint because of symptomatic arthrofibrosis following ligament injury . The mean interval between trauma and arthrolysis was 13,8 months ( range 4-50 months ) . Tissue samples were taken from the infrapatellar fat pad and intercondylar connective tissue . All samples were stained with HE . The expression of type III and VI collagen was studied immunohistochemically using an immunoperoxidase method for light microscopic visualization . Histologic analysis from patients with arthrofibrosis showed a synovial hyperplasia with cell infiltration and vascular proliferation compared to synovial tissue samples from knee joints without any detectable pathology . Subsynovial an increased deposition of matrix proteins was visible . Type VI collagen was widely distributed as a network subsynovial and around capillary walls . Type III collagen showed a diffuse distribution . Arthrofibrotic tissue is , similar to pathological conditions with fibrotic transformation characterized by an increased expression of collagen type VI . Collagen type VI may play an important role in matrix homeostasis . It serves as an anchoring element between collagen fibers and as a cell binding structure . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O" ]	Arthrofibrosis is a disabling complication after trauma and surgery due to massive connective tissue proliferation . The etiology and pathogenesis have never been fully understood . A strong immune response may lead to activation and proliferation of fibroblasts with excessive and disordered deposition of matrix proteins . In similar pathological conditions , like lung fibrosis or superficial fibromatoses with fibrotic transformation an increased expression of collagen type VI has been reported . We investigated fibrotic tissue samples taken from 18 patients ( average age : 32,7 years ) , who underwent arthrolysis of the knee joint because of symptomatic arthrofibrosis following ligament injury . The mean interval between trauma and arthrolysis was 13,8 months ( range 4-50 months ) . Tissue samples were taken from the infrapatellar fat pad and intercondylar connective tissue . All samples were stained with HE . The expression of type III and VI collagen was studied immunohistochemically using an immunoperoxidase method for light microscopic visualization . Histologic analysis from patients with arthrofibrosis showed a synovial hyperplasia with cell infiltration and vascular proliferation compared to synovial tissue samples from knee joints without any detectable pathology . Subsynovial an increased deposition of matrix proteins was visible . Type VI collagen was widely distributed as a network subsynovial and around capillary walls . Type III collagen showed a diffuse distribution . Arthrofibrotic tissue is , similar to pathological conditions with fibrotic transformation characterized by an increased expression of collagen type VI . Collagen type VI may play an important role in matrix homeostasis . It serves as an anchoring element between collagen fibers and as a cell binding structure .	[ "Arthrofibrosis", "is", "a", "disabling", "complication", "after", "trauma", "and", "surgery", "due", "to", "massive", "connective", "tissue", "proliferation", ".", "The", "etiology", "and", "pathogenesis", "have", "never", "been", "fully", "understood", ".", "A", "strong", "immune", "response", "may", "lead", "to", "activation", "and", "proliferation", "of", "fibroblasts", "with", "excessive", "and", "disordered", "deposition", "of", "matrix", "proteins", ".", "In", "similar", "pathological", "conditions", ",", "like", "lung", "fibrosis", "or", "superficial", "fibromatoses", "with", "fibrotic", "transformation", "an", "increased", "expression", "of", "collagen", "type", "VI", "has", "been", "reported", ".", "We", "investigated", "fibrotic", "tissue", "samples", "taken", "from", "18", "patients", "(", "average", "age", ":", "32,7", "years", ")", ",", "who", "underwent", "arthrolysis", "of", "the", "knee", "joint", "because", "of", "symptomatic", "arthrofibrosis", "following", "ligament", "injury", ".", "The", "mean", "interval", "between", "trauma", "and", "arthrolysis", "was", "13,8", "months", "(", "range", "4", "-", "50", "months", ")", ".", "Tissue", "samples", "were", "taken", "from", "the", "infrapatellar", "fat", "pad", "and", "intercondylar", "connective", "tissue", ".", "All", "samples", "were", "stained", "with", "HE", ".", "The", "expression", "of", "type", "III", "and", "VI", "collagen", "was", "studied", "immunohistochemically", "using", "an", "immunoperoxidase", "method", "for", "light", "microscopic", "visualization", ".", "Histologic", "analysis", "from", "patients", "with", "arthrofibrosis", "showed", "a", "synovial", "hyperplasia", "with", "cell", "infiltration", "and", "vascular", "proliferation", "compared", "to", "synovial", "tissue", "samples", "from", "knee", "joints", "without", "any", "detectable", "pathology", ".", "Subsynovial", "an", "increased", "deposition", "of", "matrix", "proteins", "was", "visible", ".", "Type", "VI", "collagen", "was", "widely", "distributed", "as", "a", "network", "subsynovial", "and", "around", "capillary", "walls", ".", "Type", "III", "collagen", "showed", "a", "diffuse", "distribution", ".", "Arthrofibrotic", "tissue", "is", ",", "similar", "to", "pathological", "conditions", "with", "fibrotic", "transformation", "characterized", "by", "an", "increased", "expression", "of", "collagen", "type", "VI", ".", "Collagen", "type", "VI", "may", "play", "an", "important", "role", "in", "matrix", "homeostasis", ".", "It", "serves", "as", "an", "anchoring", "element", "between", "collagen", "fibers", "and", "as", "a", "cell", "binding", "structure", "." ]	[ "umlsterm" ]
proximal CD19 promoter is a DNA_domain_or_region, SP1 / Egr-1 binding site is a DNA_domain_or_region, PyG box is a DNA_domain_or_region	61610_task0	Sentence: In vivo footprinting and mutational analysis of the proximal CD19 promoter reveal important roles for an SP1/Egr-1 binding site and a novel site termed the PyG box. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: DNA_domain_or_region	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "O" ]	In vivo footprinting and mutational analysis of the proximal CD19 promoter reveal important roles for an SP1/Egr-1 binding site and a novel site termed the PyG box.	[ "In", "vivo", "footprinting", "and", "mutational", "analysis", "of", "the", "proximal", "CD19", "promoter", "reveal", "important", "roles", "for", "an", "SP1", "/", "Egr-1", "binding", "site", "and", "a", "novel", "site", "termed", "the", "PyG", "box", "." ]	[ "DNA_domain_or_region", "protein_molecule", "other_name", "DNA_molecule", "DNA_family_or_group", "(AND DNA_domain_or_region DNA_domain_or_region)", "cell_line", "cell_type", "other_organic_compound", "" ]
proximal CD19 promoter is a DNA_domain_or_region, SP1 / Egr-1 binding site is a DNA_domain_or_region, PyG box is a DNA_domain_or_region	61610_task1	Sentence: In vivo footprinting and mutational analysis of the proximal CD19 promoter reveal important roles for an SP1/Egr-1 binding site and a novel site termed the PyG box. Instructions: please typing these entity words according to sentence: proximal CD19 promoter, SP1 / Egr-1 binding site, PyG box Options: DNA_domain_or_region	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "O" ]	In vivo footprinting and mutational analysis of the proximal CD19 promoter reveal important roles for an SP1/Egr-1 binding site and a novel site termed the PyG box.	[ "In", "vivo", "footprinting", "and", "mutational", "analysis", "of", "the", "proximal", "CD19", "promoter", "reveal", "important", "roles", "for", "an", "SP1", "/", "Egr-1", "binding", "site", "and", "a", "novel", "site", "termed", "the", "PyG", "box", "." ]	[ "DNA_domain_or_region", "protein_molecule", "other_name", "DNA_molecule", "DNA_family_or_group", "(AND DNA_domain_or_region DNA_domain_or_region)", "cell_line", "cell_type", "other_organic_compound", "" ]
proximal CD19 promoter, SP1 / Egr-1 binding site, PyG box	61610_task2	Sentence: In vivo footprinting and mutational analysis of the proximal CD19 promoter reveal important roles for an SP1/Egr-1 binding site and a novel site termed the PyG box. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "O" ]	In vivo footprinting and mutational analysis of the proximal CD19 promoter reveal important roles for an SP1/Egr-1 binding site and a novel site termed the PyG box.	[ "In", "vivo", "footprinting", "and", "mutational", "analysis", "of", "the", "proximal", "CD19", "promoter", "reveal", "important", "roles", "for", "an", "SP1", "/", "Egr-1", "binding", "site", "and", "a", "novel", "site", "termed", "the", "PyG", "box", "." ]	[ "DNA_domain_or_region", "protein_molecule", "other_name", "DNA_molecule", "DNA_family_or_group", "(AND DNA_domain_or_region DNA_domain_or_region)", "cell_line", "cell_type", "other_organic_compound", "" ]
APC resistance is an umlsterm, form is an umlsterm, factor V is an umlsterm, factor V Leiden is an umlsterm, cause is an umlsterm, thrombosis is an umlsterm, association is an umlsterm, protein C is an umlsterm, retinal vein occlusion is an umlsterm, prevalence is an umlsterm, APC resistance is an umlsterm, patients is an umlsterm, patients is an umlsterm, history is an umlsterm, deep - vein thrombosis is an umlsterm, control group is an umlsterm	DerOpthalmologe.90960594.eng.abstr_task0	Sentence: Background : The recently described " APC resistance " caused by a mutant form of factor V ( factor V Leiden ) is the most frequent cause of hereditary thrombosis . This study was carried out to investigate the association between activated protein C resistance and central retinal vein occlusion ( CRVO ) . We evaluated the prevalence of APC resistance in patients with CRVO , patients with a history of deep-vein thrombosis , and a healthy control group . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]	Background : The recently described " APC resistance " caused by a mutant form of factor V ( factor V Leiden ) is the most frequent cause of hereditary thrombosis . This study was carried out to investigate the association between activated protein C resistance and central retinal vein occlusion ( CRVO ) . We evaluated the prevalence of APC resistance in patients with CRVO , patients with a history of deep-vein thrombosis , and a healthy control group .	[ "Background", ":", "The", "recently", "described", "\"", "APC", "resistance", "\"", "caused", "by", "a", "mutant", "form", "of", "factor", "V", "(", "factor", "V", "Leiden", ")", "is", "the", "most", "frequent", "cause", "of", "hereditary", "thrombosis", ".", "This", "study", "was", "carried", "out", "to", "investigate", "the", "association", "between", "activated", "protein", "C", "resistance", "and", "central", "retinal", "vein", "occlusion", "(", "CRVO", ")", ".", "We", "evaluated", "the", "prevalence", "of", "APC", "resistance", "in", "patients", "with", "CRVO", ",", "patients", "with", "a", "history", "of", "deep", "-", "vein", "thrombosis", ",", "and", "a", "healthy", "control", "group", "." ]	[ "umlsterm" ]
APC resistance is an umlsterm, form is an umlsterm, factor V is an umlsterm, factor V Leiden is an umlsterm, cause is an umlsterm, thrombosis is an umlsterm, association is an umlsterm, protein C is an umlsterm, retinal vein occlusion is an umlsterm, prevalence is an umlsterm, APC resistance is an umlsterm, patients is an umlsterm, patients is an umlsterm, history is an umlsterm, deep - vein thrombosis is an umlsterm, control group is an umlsterm	DerOpthalmologe.90960594.eng.abstr_task1	Sentence: Background : The recently described " APC resistance " caused by a mutant form of factor V ( factor V Leiden ) is the most frequent cause of hereditary thrombosis . This study was carried out to investigate the association between activated protein C resistance and central retinal vein occlusion ( CRVO ) . We evaluated the prevalence of APC resistance in patients with CRVO , patients with a history of deep-vein thrombosis , and a healthy control group . Instructions: please typing these entity words according to sentence: APC resistance, form, factor V, factor V Leiden, cause, thrombosis, association, protein C, retinal vein occlusion, prevalence, APC resistance, patients, patients, history, deep - vein thrombosis, control group Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]	Background : The recently described " APC resistance " caused by a mutant form of factor V ( factor V Leiden ) is the most frequent cause of hereditary thrombosis . This study was carried out to investigate the association between activated protein C resistance and central retinal vein occlusion ( CRVO ) . We evaluated the prevalence of APC resistance in patients with CRVO , patients with a history of deep-vein thrombosis , and a healthy control group .	[ "Background", ":", "The", "recently", "described", "\"", "APC", "resistance", "\"", "caused", "by", "a", "mutant", "form", "of", "factor", "V", "(", "factor", "V", "Leiden", ")", "is", "the", "most", "frequent", "cause", "of", "hereditary", "thrombosis", ".", "This", "study", "was", "carried", "out", "to", "investigate", "the", "association", "between", "activated", "protein", "C", "resistance", "and", "central", "retinal", "vein", "occlusion", "(", "CRVO", ")", ".", "We", "evaluated", "the", "prevalence", "of", "APC", "resistance", "in", "patients", "with", "CRVO", ",", "patients", "with", "a", "history", "of", "deep", "-", "vein", "thrombosis", ",", "and", "a", "healthy", "control", "group", "." ]	[ "umlsterm" ]
APC resistance, form, factor V, factor V Leiden, cause, thrombosis, association, protein C, retinal vein occlusion, prevalence, APC resistance, patients, patients, history, deep - vein thrombosis, control group	DerOpthalmologe.90960594.eng.abstr_task2	Sentence: Background : The recently described " APC resistance " caused by a mutant form of factor V ( factor V Leiden ) is the most frequent cause of hereditary thrombosis . This study was carried out to investigate the association between activated protein C resistance and central retinal vein occlusion ( CRVO ) . We evaluated the prevalence of APC resistance in patients with CRVO , patients with a history of deep-vein thrombosis , and a healthy control group . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]	Background : The recently described " APC resistance " caused by a mutant form of factor V ( factor V Leiden ) is the most frequent cause of hereditary thrombosis . This study was carried out to investigate the association between activated protein C resistance and central retinal vein occlusion ( CRVO ) . We evaluated the prevalence of APC resistance in patients with CRVO , patients with a history of deep-vein thrombosis , and a healthy control group .	[ "Background", ":", "The", "recently", "described", "\"", "APC", "resistance", "\"", "caused", "by", "a", "mutant", "form", "of", "factor", "V", "(", "factor", "V", "Leiden", ")", "is", "the", "most", "frequent", "cause", "of", "hereditary", "thrombosis", ".", "This", "study", "was", "carried", "out", "to", "investigate", "the", "association", "between", "activated", "protein", "C", "resistance", "and", "central", "retinal", "vein", "occlusion", "(", "CRVO", ")", ".", "We", "evaluated", "the", "prevalence", "of", "APC", "resistance", "in", "patients", "with", "CRVO", ",", "patients", "with", "a", "history", "of", "deep", "-", "vein", "thrombosis", ",", "and", "a", "healthy", "control", "group", "." ]	[ "umlsterm" ]
ginsenoside Rg3 is a compound, AMPK is a protein, PPAR - gamma is a protein	DS.d1580_task0	Sentence: Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR-gamma signal pathways. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein	[ "O", "O", "O", "B-compound", "I-compound", "O", "O", "B-protein", "O", "B-protein", "I-protein", "I-protein", "O", "O", "O" ]	Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR-gamma signal pathways.	[ "Antiobesity", "effect", "of", "ginsenoside", "Rg3", "involves", "the", "AMPK", "and", "PPAR", "-", "gamma", "signal", "pathways", "." ]	[ "compound", "protein" ]
ginsenoside Rg3 is a compound, AMPK is a protein, PPAR - gamma is a protein	DS.d1580_task1	Sentence: Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR-gamma signal pathways. Instructions: please typing these entity words according to sentence: ginsenoside Rg3, AMPK, PPAR - gamma Options: compound, protein	[ "O", "O", "O", "B-compound", "I-compound", "O", "O", "B-protein", "O", "B-protein", "I-protein", "I-protein", "O", "O", "O" ]	Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR-gamma signal pathways.	[ "Antiobesity", "effect", "of", "ginsenoside", "Rg3", "involves", "the", "AMPK", "and", "PPAR", "-", "gamma", "signal", "pathways", "." ]	[ "compound", "protein" ]
ginsenoside Rg3, AMPK, PPAR - gamma	DS.d1580_task2	Sentence: Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR-gamma signal pathways. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-compound", "I-compound", "O", "O", "B-protein", "O", "B-protein", "I-protein", "I-protein", "O", "O", "O" ]	Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR-gamma signal pathways.	[ "Antiobesity", "effect", "of", "ginsenoside", "Rg3", "involves", "the", "AMPK", "and", "PPAR", "-", "gamma", "signal", "pathways", "." ]	[ "compound", "protein" ]
iron dextran is a compound, Hamp is a protein	DS.d729_task0	Sentence: Macrophages isolated from iron deficient rats, or pregnant rats at day 21 of gestation, either supplemented with a single dose of iron dextran, 10 mg, at the commencement of pregnancy, or not, showed significant increases of macrophage ferroportin mRNA expression, which was paralleled by significant decreases in hepatic Hamp mRNA expression. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O" ]	Macrophages isolated from iron deficient rats, or pregnant rats at day 21 of gestation, either supplemented with a single dose of iron dextran, 10 mg, at the commencement of pregnancy, or not, showed significant increases of macrophage ferroportin mRNA expression, which was paralleled by significant decreases in hepatic Hamp mRNA expression.	[ "Macrophages", "isolated", "from", "iron", "deficient", "rats", ",", "or", "pregnant", "rats", "at", "day", "21", "of", "gestation", ",", "either", "supplemented", "with", "a", "single", "dose", "of", "iron", "dextran", ",", "10", "mg", ",", "at", "the", "commencement", "of", "pregnancy", ",", "or", "not", ",", "showed", "significant", "increases", "of", "macrophage", "ferroportin", "mRNA", "expression", ",", "which", "was", "paralleled", "by", "significant", "decreases", "in", "hepatic", "Hamp", "mRNA", "expression", "." ]	[ "compound", "protein" ]
iron dextran is a compound, Hamp is a protein	DS.d729_task1	Sentence: Macrophages isolated from iron deficient rats, or pregnant rats at day 21 of gestation, either supplemented with a single dose of iron dextran, 10 mg, at the commencement of pregnancy, or not, showed significant increases of macrophage ferroportin mRNA expression, which was paralleled by significant decreases in hepatic Hamp mRNA expression. Instructions: please typing these entity words according to sentence: iron dextran, Hamp Options: compound, protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O" ]	Macrophages isolated from iron deficient rats, or pregnant rats at day 21 of gestation, either supplemented with a single dose of iron dextran, 10 mg, at the commencement of pregnancy, or not, showed significant increases of macrophage ferroportin mRNA expression, which was paralleled by significant decreases in hepatic Hamp mRNA expression.	[ "Macrophages", "isolated", "from", "iron", "deficient", "rats", ",", "or", "pregnant", "rats", "at", "day", "21", "of", "gestation", ",", "either", "supplemented", "with", "a", "single", "dose", "of", "iron", "dextran", ",", "10", "mg", ",", "at", "the", "commencement", "of", "pregnancy", ",", "or", "not", ",", "showed", "significant", "increases", "of", "macrophage", "ferroportin", "mRNA", "expression", ",", "which", "was", "paralleled", "by", "significant", "decreases", "in", "hepatic", "Hamp", "mRNA", "expression", "." ]	[ "compound", "protein" ]
iron dextran, Hamp	DS.d729_task2	Sentence: Macrophages isolated from iron deficient rats, or pregnant rats at day 21 of gestation, either supplemented with a single dose of iron dextran, 10 mg, at the commencement of pregnancy, or not, showed significant increases of macrophage ferroportin mRNA expression, which was paralleled by significant decreases in hepatic Hamp mRNA expression. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O" ]	Macrophages isolated from iron deficient rats, or pregnant rats at day 21 of gestation, either supplemented with a single dose of iron dextran, 10 mg, at the commencement of pregnancy, or not, showed significant increases of macrophage ferroportin mRNA expression, which was paralleled by significant decreases in hepatic Hamp mRNA expression.	[ "Macrophages", "isolated", "from", "iron", "deficient", "rats", ",", "or", "pregnant", "rats", "at", "day", "21", "of", "gestation", ",", "either", "supplemented", "with", "a", "single", "dose", "of", "iron", "dextran", ",", "10", "mg", ",", "at", "the", "commencement", "of", "pregnancy", ",", "or", "not", ",", "showed", "significant", "increases", "of", "macrophage", "ferroportin", "mRNA", "expression", ",", "which", "was", "paralleled", "by", "significant", "decreases", "in", "hepatic", "Hamp", "mRNA", "expression", "." ]	[ "compound", "protein" ]
use is an umlsterm, telephone is an umlsterm, elderly is an umlsterm, analyses is an umlsterm, Elderly is an umlsterm, West Germany is an umlsterm, respondents is an umlsterm, East Germany is an umlsterm, Italy is an umlsterm, Finland is an umlsterm, age is an umlsterm, gender is an umlsterm, generations is an umlsterm, men is an umlsterm, women is an umlsterm, respondents is an umlsterm, use is an umlsterm, technologies is an umlsterm, respondents is an umlsterm, devices is an umlsterm, telephone is an umlsterm, logistic regression is an umlsterm, analysis is an umlsterm, age is an umlsterm, technologies is an umlsterm, young - old is an umlsterm, Education is an umlsterm, gender is an umlsterm, respondents is an umlsterm, technologies is an umlsterm, life is an umlsterm, life is an umlsterm, elderly is an umlsterm, technology is an umlsterm, future is an umlsterm, research is an umlsterm	ZfuerGerontologie+Geriatrie.00330169.eng.abstr_task0	Sentence: This article examines the use and acceptance of ticket machines , automatic teller machines ( ATMs ) and telephone cards by the elderly in four European regions . The analyses are based on data from an international project entitled " Keeping the Elderly Mobile " , collected in Mannheim ( former West Germany ; N=404 home-dwelling respondents ) , Chemnitz ( former East Germany ; N=400), Ancona ( Italy ; N=600), and Jyvaeskylae ( Finland ; N=618). The random sample was stratified by age and gender in each country . Two generations of men and women ( aged 55-74 and 75+ years , respectively ) participated in the study . Results show that respondents generally made little use of the three technologies under investigation : in fact , the majority of respondents does not use them at all . The most frequently used devices were ATMs in Chemnitz and ticket machines and telephone cards in Mannheim . On the basis of logistic regression analysis , age was the most important explanatory factor for the three technologies and for all four regions , i.e. , the users were mostly the " young-old . " Education was a more important variable than gender . In all four regions , the majority of the respondents who used the technologies assessed felt that each of them made life easier ; nevertheless , ticket machines make life more difficult to almost every third user in Mannheim . Interesting differences and similarities among the towns were also found . The present study exhibits preliminary results regarding elderly and technology which future research should investigate in greater depth . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]	This article examines the use and acceptance of ticket machines , automatic teller machines ( ATMs ) and telephone cards by the elderly in four European regions . The analyses are based on data from an international project entitled " Keeping the Elderly Mobile " , collected in Mannheim ( former West Germany ; N=404 home-dwelling respondents ) , Chemnitz ( former East Germany ; N=400), Ancona ( Italy ; N=600), and Jyvaeskylae ( Finland ; N=618). The random sample was stratified by age and gender in each country . Two generations of men and women ( aged 55-74 and 75+ years , respectively ) participated in the study . Results show that respondents generally made little use of the three technologies under investigation : in fact , the majority of respondents does not use them at all . The most frequently used devices were ATMs in Chemnitz and ticket machines and telephone cards in Mannheim . On the basis of logistic regression analysis , age was the most important explanatory factor for the three technologies and for all four regions , i.e. , the users were mostly the " young-old . " Education was a more important variable than gender . In all four regions , the majority of the respondents who used the technologies assessed felt that each of them made life easier ; nevertheless , ticket machines make life more difficult to almost every third user in Mannheim . Interesting differences and similarities among the towns were also found . The present study exhibits preliminary results regarding elderly and technology which future research should investigate in greater depth .	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use is an umlsterm, telephone is an umlsterm, elderly is an umlsterm, analyses is an umlsterm, Elderly is an umlsterm, West Germany is an umlsterm, respondents is an umlsterm, East Germany is an umlsterm, Italy is an umlsterm, Finland is an umlsterm, age is an umlsterm, gender is an umlsterm, generations is an umlsterm, men is an umlsterm, women is an umlsterm, respondents is an umlsterm, use is an umlsterm, technologies is an umlsterm, respondents is an umlsterm, devices is an umlsterm, telephone is an umlsterm, logistic regression is an umlsterm, analysis is an umlsterm, age is an umlsterm, technologies is an umlsterm, young - old is an umlsterm, Education is an umlsterm, gender is an umlsterm, respondents is an umlsterm, technologies is an umlsterm, life is an umlsterm, life is an umlsterm, elderly is an umlsterm, technology is an umlsterm, future is an umlsterm, research is an umlsterm	ZfuerGerontologie+Geriatrie.00330169.eng.abstr_task1	Sentence: This article examines the use and acceptance of ticket machines , automatic teller machines ( ATMs ) and telephone cards by the elderly in four European regions . The analyses are based on data from an international project entitled " Keeping the Elderly Mobile " , collected in Mannheim ( former West Germany ; N=404 home-dwelling respondents ) , Chemnitz ( former East Germany ; N=400), Ancona ( Italy ; N=600), and Jyvaeskylae ( Finland ; N=618). The random sample was stratified by age and gender in each country . Two generations of men and women ( aged 55-74 and 75+ years , respectively ) participated in the study . Results show that respondents generally made little use of the three technologies under investigation : in fact , the majority of respondents does not use them at all . The most frequently used devices were ATMs in Chemnitz and ticket machines and telephone cards in Mannheim . On the basis of logistic regression analysis , age was the most important explanatory factor for the three technologies and for all four regions , i.e. , the users were mostly the " young-old . " Education was a more important variable than gender . In all four regions , the majority of the respondents who used the technologies assessed felt that each of them made life easier ; nevertheless , ticket machines make life more difficult to almost every third user in Mannheim . Interesting differences and similarities among the towns were also found . The present study exhibits preliminary results regarding elderly and technology which future research should investigate in greater depth . Instructions: please typing these entity words according to sentence: use, telephone, elderly, analyses, Elderly, West Germany, respondents, East Germany, Italy, Finland, age, gender, generations, men, women, respondents, use, technologies, respondents, devices, telephone, logistic regression, analysis, age, technologies, young - old, Education, gender, respondents, technologies, life, life, elderly, technology, future, research Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]	This article examines the use and acceptance of ticket machines , automatic teller machines ( ATMs ) and telephone cards by the elderly in four European regions . The analyses are based on data from an international project entitled " Keeping the Elderly Mobile " , collected in Mannheim ( former West Germany ; N=404 home-dwelling respondents ) , Chemnitz ( former East Germany ; N=400), Ancona ( Italy ; N=600), and Jyvaeskylae ( Finland ; N=618). The random sample was stratified by age and gender in each country . Two generations of men and women ( aged 55-74 and 75+ years , respectively ) participated in the study . Results show that respondents generally made little use of the three technologies under investigation : in fact , the majority of respondents does not use them at all . The most frequently used devices were ATMs in Chemnitz and ticket machines and telephone cards in Mannheim . On the basis of logistic regression analysis , age was the most important explanatory factor for the three technologies and for all four regions , i.e. , the users were mostly the " young-old . " Education was a more important variable than gender . In all four regions , the majority of the respondents who used the technologies assessed felt that each of them made life easier ; nevertheless , ticket machines make life more difficult to almost every third user in Mannheim . Interesting differences and similarities among the towns were also found . The present study exhibits preliminary results regarding elderly and technology which future research should investigate in greater depth .	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use, telephone, elderly, analyses, Elderly, West Germany, respondents, East Germany, Italy, Finland, age, gender, generations, men, women, respondents, use, technologies, respondents, devices, telephone, logistic regression, analysis, age, technologies, young - old, Education, gender, respondents, technologies, life, life, elderly, technology, future, research	ZfuerGerontologie+Geriatrie.00330169.eng.abstr_task2	Sentence: This article examines the use and acceptance of ticket machines , automatic teller machines ( ATMs ) and telephone cards by the elderly in four European regions . The analyses are based on data from an international project entitled " Keeping the Elderly Mobile " , collected in Mannheim ( former West Germany ; N=404 home-dwelling respondents ) , Chemnitz ( former East Germany ; N=400), Ancona ( Italy ; N=600), and Jyvaeskylae ( Finland ; N=618). The random sample was stratified by age and gender in each country . Two generations of men and women ( aged 55-74 and 75+ years , respectively ) participated in the study . Results show that respondents generally made little use of the three technologies under investigation : in fact , the majority of respondents does not use them at all . The most frequently used devices were ATMs in Chemnitz and ticket machines and telephone cards in Mannheim . On the basis of logistic regression analysis , age was the most important explanatory factor for the three technologies and for all four regions , i.e. , the users were mostly the " young-old . " Education was a more important variable than gender . In all four regions , the majority of the respondents who used the technologies assessed felt that each of them made life easier ; nevertheless , ticket machines make life more difficult to almost every third user in Mannheim . Interesting differences and similarities among the towns were also found . The present study exhibits preliminary results regarding elderly and technology which future research should investigate in greater depth . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]	This article examines the use and acceptance of ticket machines , automatic teller machines ( ATMs ) and telephone cards by the elderly in four European regions . The analyses are based on data from an international project entitled " Keeping the Elderly Mobile " , collected in Mannheim ( former West Germany ; N=404 home-dwelling respondents ) , Chemnitz ( former East Germany ; N=400), Ancona ( Italy ; N=600), and Jyvaeskylae ( Finland ; N=618). The random sample was stratified by age and gender in each country . Two generations of men and women ( aged 55-74 and 75+ years , respectively ) participated in the study . Results show that respondents generally made little use of the three technologies under investigation : in fact , the majority of respondents does not use them at all . The most frequently used devices were ATMs in Chemnitz and ticket machines and telephone cards in Mannheim . On the basis of logistic regression analysis , age was the most important explanatory factor for the three technologies and for all four regions , i.e. , the users were mostly the " young-old . " Education was a more important variable than gender . In all four regions , the majority of the respondents who used the technologies assessed felt that each of them made life easier ; nevertheless , ticket machines make life more difficult to almost every third user in Mannheim . Interesting differences and similarities among the towns were also found . The present study exhibits preliminary results regarding elderly and technology which future research should investigate in greater depth .	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Gelenkinfekten is an umlsterm, unfallchirurgischen is an umlsterm, Methoden is an umlsterm, gezielte is an umlsterm, kombinierten Therapie is an umlsterm, Hueftgelenkersatz is an umlsterm, Chemotherapie is an umlsterm, Therapieergebnisses is an umlsterm, Literatur is an umlsterm	DerUnfallchirurg.01030401.ger.abstr_task0	Sentence: Die Moeglichkeit einer spezifischen Genese von Gelenkinfekten und Spondylitiden ist in die differentialdiagnostischen Ueberlegungen einzubeziehen . Dies wird anhand eines Falls einer Coxitis tuberculosa demonstriert , welcher in Zusammenarbeit der unfallchirurgischen mit der medizinischen Klinik des Klinikums Minden therapiert wurde . Ein differenziertes diagnostisches Vorgehen mit bildgebenden und mikrobiologischen Methoden erlaubt eine gezielte Planung und Durchfuehrung einer kombinierten Therapie aus operativem endoprothetischen Hueftgelenkersatz und antituberkuloeser Chemotherapie . Nach kritischer Bewertung des Therapieergebnisses und Diskussion der Literatur ist das praesentierte Vorgehen erfolgreich , sowohl die lokale Sanierung des Infekts , als auch das funktionelle Ergebnis betreffend . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Die Moeglichkeit einer spezifischen Genese von Gelenkinfekten und Spondylitiden ist in die differentialdiagnostischen Ueberlegungen einzubeziehen . Dies wird anhand eines Falls einer Coxitis tuberculosa demonstriert , welcher in Zusammenarbeit der unfallchirurgischen mit der medizinischen Klinik des Klinikums Minden therapiert wurde . Ein differenziertes diagnostisches Vorgehen mit bildgebenden und mikrobiologischen Methoden erlaubt eine gezielte Planung und Durchfuehrung einer kombinierten Therapie aus operativem endoprothetischen Hueftgelenkersatz und antituberkuloeser Chemotherapie . Nach kritischer Bewertung des Therapieergebnisses und Diskussion der Literatur ist das praesentierte Vorgehen erfolgreich , sowohl die lokale Sanierung des Infekts , als auch das funktionelle Ergebnis betreffend .	[ "Die", "Moeglichkeit", "einer", "spezifischen", "Genese", "von", "Gelenkinfekten", "und", "Spondylitiden", "ist", "in", "die", "differentialdiagnostischen", "Ueberlegungen", "einzubeziehen", ".", "Dies", "wird", "anhand", "eines", "Falls", "einer", "Coxitis", "tuberculosa", "demonstriert", ",", "welcher", "in", "Zusammenarbeit", "der", "unfallchirurgischen", "mit", "der", "medizinischen", "Klinik", "des", "Klinikums", "Minden", "therapiert", "wurde", ".", "Ein", "differenziertes", "diagnostisches", "Vorgehen", "mit", "bildgebenden", "und", "mikrobiologischen", "Methoden", "erlaubt", "eine", "gezielte", "Planung", "und", "Durchfuehrung", "einer", "kombinierten", "Therapie", "aus", "operativem", "endoprothetischen", "Hueftgelenkersatz", "und", "antituberkuloeser", "Chemotherapie", ".", "Nach", "kritischer", "Bewertung", "des", "Therapieergebnisses", "und", "Diskussion", "der", "Literatur", "ist", "das", "praesentierte", "Vorgehen", "erfolgreich", ",", "sowohl", "die", "lokale", "Sanierung", "des", "Infekts", ",", "als", "auch", "das", "funktionelle", "Ergebnis", "betreffend", "." ]	[ "umlsterm" ]
Gelenkinfekten is an umlsterm, unfallchirurgischen is an umlsterm, Methoden is an umlsterm, gezielte is an umlsterm, kombinierten Therapie is an umlsterm, Hueftgelenkersatz is an umlsterm, Chemotherapie is an umlsterm, Therapieergebnisses is an umlsterm, Literatur is an umlsterm	DerUnfallchirurg.01030401.ger.abstr_task1	Sentence: Die Moeglichkeit einer spezifischen Genese von Gelenkinfekten und Spondylitiden ist in die differentialdiagnostischen Ueberlegungen einzubeziehen . Dies wird anhand eines Falls einer Coxitis tuberculosa demonstriert , welcher in Zusammenarbeit der unfallchirurgischen mit der medizinischen Klinik des Klinikums Minden therapiert wurde . Ein differenziertes diagnostisches Vorgehen mit bildgebenden und mikrobiologischen Methoden erlaubt eine gezielte Planung und Durchfuehrung einer kombinierten Therapie aus operativem endoprothetischen Hueftgelenkersatz und antituberkuloeser Chemotherapie . Nach kritischer Bewertung des Therapieergebnisses und Diskussion der Literatur ist das praesentierte Vorgehen erfolgreich , sowohl die lokale Sanierung des Infekts , als auch das funktionelle Ergebnis betreffend . Instructions: please typing these entity words according to sentence: Gelenkinfekten, unfallchirurgischen, Methoden, gezielte, kombinierten Therapie, Hueftgelenkersatz, Chemotherapie, Therapieergebnisses, Literatur Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Die Moeglichkeit einer spezifischen Genese von Gelenkinfekten und Spondylitiden ist in die differentialdiagnostischen Ueberlegungen einzubeziehen . Dies wird anhand eines Falls einer Coxitis tuberculosa demonstriert , welcher in Zusammenarbeit der unfallchirurgischen mit der medizinischen Klinik des Klinikums Minden therapiert wurde . Ein differenziertes diagnostisches Vorgehen mit bildgebenden und mikrobiologischen Methoden erlaubt eine gezielte Planung und Durchfuehrung einer kombinierten Therapie aus operativem endoprothetischen Hueftgelenkersatz und antituberkuloeser Chemotherapie . Nach kritischer Bewertung des Therapieergebnisses und Diskussion der Literatur ist das praesentierte Vorgehen erfolgreich , sowohl die lokale Sanierung des Infekts , als auch das funktionelle Ergebnis betreffend .	[ "Die", "Moeglichkeit", "einer", "spezifischen", "Genese", "von", "Gelenkinfekten", "und", "Spondylitiden", "ist", "in", "die", "differentialdiagnostischen", "Ueberlegungen", "einzubeziehen", ".", "Dies", "wird", "anhand", "eines", "Falls", "einer", "Coxitis", "tuberculosa", "demonstriert", ",", "welcher", "in", "Zusammenarbeit", "der", "unfallchirurgischen", "mit", "der", "medizinischen", "Klinik", "des", "Klinikums", "Minden", "therapiert", "wurde", ".", "Ein", "differenziertes", "diagnostisches", "Vorgehen", "mit", "bildgebenden", "und", "mikrobiologischen", "Methoden", "erlaubt", "eine", "gezielte", "Planung", "und", "Durchfuehrung", "einer", "kombinierten", "Therapie", "aus", "operativem", "endoprothetischen", "Hueftgelenkersatz", "und", "antituberkuloeser", "Chemotherapie", ".", "Nach", "kritischer", "Bewertung", "des", "Therapieergebnisses", "und", "Diskussion", "der", "Literatur", "ist", "das", "praesentierte", "Vorgehen", "erfolgreich", ",", "sowohl", "die", "lokale", "Sanierung", "des", "Infekts", ",", "als", "auch", "das", "funktionelle", "Ergebnis", "betreffend", "." ]	[ "umlsterm" ]
Gelenkinfekten, unfallchirurgischen, Methoden, gezielte, kombinierten Therapie, Hueftgelenkersatz, Chemotherapie, Therapieergebnisses, Literatur	DerUnfallchirurg.01030401.ger.abstr_task2	Sentence: Die Moeglichkeit einer spezifischen Genese von Gelenkinfekten und Spondylitiden ist in die differentialdiagnostischen Ueberlegungen einzubeziehen . Dies wird anhand eines Falls einer Coxitis tuberculosa demonstriert , welcher in Zusammenarbeit der unfallchirurgischen mit der medizinischen Klinik des Klinikums Minden therapiert wurde . Ein differenziertes diagnostisches Vorgehen mit bildgebenden und mikrobiologischen Methoden erlaubt eine gezielte Planung und Durchfuehrung einer kombinierten Therapie aus operativem endoprothetischen Hueftgelenkersatz und antituberkuloeser Chemotherapie . Nach kritischer Bewertung des Therapieergebnisses und Diskussion der Literatur ist das praesentierte Vorgehen erfolgreich , sowohl die lokale Sanierung des Infekts , als auch das funktionelle Ergebnis betreffend . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Die Moeglichkeit einer spezifischen Genese von Gelenkinfekten und Spondylitiden ist in die differentialdiagnostischen Ueberlegungen einzubeziehen . Dies wird anhand eines Falls einer Coxitis tuberculosa demonstriert , welcher in Zusammenarbeit der unfallchirurgischen mit der medizinischen Klinik des Klinikums Minden therapiert wurde . Ein differenziertes diagnostisches Vorgehen mit bildgebenden und mikrobiologischen Methoden erlaubt eine gezielte Planung und Durchfuehrung einer kombinierten Therapie aus operativem endoprothetischen Hueftgelenkersatz und antituberkuloeser Chemotherapie . Nach kritischer Bewertung des Therapieergebnisses und Diskussion der Literatur ist das praesentierte Vorgehen erfolgreich , sowohl die lokale Sanierung des Infekts , als auch das funktionelle Ergebnis betreffend .	[ "Die", "Moeglichkeit", "einer", "spezifischen", "Genese", "von", "Gelenkinfekten", "und", "Spondylitiden", "ist", "in", "die", "differentialdiagnostischen", "Ueberlegungen", "einzubeziehen", ".", "Dies", "wird", "anhand", "eines", "Falls", "einer", "Coxitis", "tuberculosa", "demonstriert", ",", "welcher", "in", "Zusammenarbeit", "der", "unfallchirurgischen", "mit", "der", "medizinischen", "Klinik", "des", "Klinikums", "Minden", "therapiert", "wurde", ".", "Ein", "differenziertes", "diagnostisches", "Vorgehen", "mit", "bildgebenden", "und", "mikrobiologischen", "Methoden", "erlaubt", "eine", "gezielte", "Planung", "und", "Durchfuehrung", "einer", "kombinierten", "Therapie", "aus", "operativem", "endoprothetischen", "Hueftgelenkersatz", "und", "antituberkuloeser", "Chemotherapie", ".", "Nach", "kritischer", "Bewertung", "des", "Therapieergebnisses", "und", "Diskussion", "der", "Literatur", "ist", "das", "praesentierte", "Vorgehen", "erfolgreich", ",", "sowohl", "die", "lokale", "Sanierung", "des", "Infekts", ",", "als", "auch", "das", "funktionelle", "Ergebnis", "betreffend", "." ]	[ "umlsterm" ]
Effizienz is an umlsterm, Geburtseinleitung is an umlsterm, Muttermundsverhaeltnissen is an umlsterm, Geburtseinleitung is an umlsterm	PerinatalMedizin.80100081.ger.abstr_task0	Sentence: Im Rahmen einer prospektiven randomisierten Multicenterstudie wurde bei 796 Patientinnen die Effizienz der Geburtseinleitung mittels 2 mg PGE2-Vaginalgel vs. 0,5 mg Intrazervikalgel bei unreifer Zervix ( Bishop-Score 3-4 ) und von 2 mg PGE2-Vaginalgel vs. der 3 mg PGE2-Vaginaltablette bei reifer Zervix ( Bishop-Score 5-7 ) vergleichend untersucht . Bei unreifen Muttermundsverhaeltnissen wies das 2 mg PGE2-Vaginalgel hinsichtlich des Reifungseffekts , der medianen Induktionsgeburtsintervalle und der kumulativen Entbindungsraten/24 h signifikant bessere Ergebnisse auf als das Intrazervikalgel ; keine signifikanten Unterschiede ergaben sich in der Haeufigkeit uteriner Ueberstimulierungen , unerwuenschter maternaler Begleitwirkungen , der Sectiorate und im fetal outcome " . " Bei reifer Zervix erwiesen sich das 2 mg PGE2-Vaginalgel und die 3 mg PGE2-Vaginaltablette als aequieffektiv . Mit dem 2 mg PGE2-Vaginalgel steht eine effiziente Applikationsform fuer die Geburtseinleitung ab einem Bishop-Score > =3 zur Verfuegung . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Im Rahmen einer prospektiven randomisierten Multicenterstudie wurde bei 796 Patientinnen die Effizienz der Geburtseinleitung mittels 2 mg PGE2-Vaginalgel vs. 0,5 mg Intrazervikalgel bei unreifer Zervix ( Bishop-Score 3-4 ) und von 2 mg PGE2-Vaginalgel vs. der 3 mg PGE2-Vaginaltablette bei reifer Zervix ( Bishop-Score 5-7 ) vergleichend untersucht . Bei unreifen Muttermundsverhaeltnissen wies das 2 mg PGE2-Vaginalgel hinsichtlich des Reifungseffekts , der medianen Induktionsgeburtsintervalle und der kumulativen Entbindungsraten/24 h signifikant bessere Ergebnisse auf als das Intrazervikalgel ; keine signifikanten Unterschiede ergaben sich in der Haeufigkeit uteriner Ueberstimulierungen , unerwuenschter maternaler Begleitwirkungen , der Sectiorate und im fetal outcome " . " Bei reifer Zervix erwiesen sich das 2 mg PGE2-Vaginalgel und die 3 mg PGE2-Vaginaltablette als aequieffektiv . Mit dem 2 mg PGE2-Vaginalgel steht eine effiziente Applikationsform fuer die Geburtseinleitung ab einem Bishop-Score > =3 zur Verfuegung .	[ "Im", "Rahmen", "einer", "prospektiven", "randomisierten", "Multicenterstudie", "wurde", "bei", "796", "Patientinnen", "die", "Effizienz", "der", "Geburtseinleitung", "mittels", "2", "mg", "PGE2-Vaginalgel", "vs", ".", "0,5", "mg", "Intrazervikalgel", "bei", "unreifer", "Zervix", "(", "Bishop", "-", "Score", "3", "-", "4", ")", "und", "von", "2", "mg", "PGE2-Vaginalgel", "vs", ".", "der", "3", "mg", "PGE2-Vaginaltablette", "bei", "reifer", "Zervix", "(", "Bishop", "-", "Score", "5", "-", "7", ")", "vergleichend", "untersucht", ".", "Bei", "unreifen", "Muttermundsverhaeltnissen", "wies", "das", "2", "mg", "PGE2-Vaginalgel", "hinsichtlich", "des", "Reifungseffekts", ",", "der", "medianen", "Induktionsgeburtsintervalle", "und", "der", "kumulativen", "Entbindungsraten/24", "h", "signifikant", "bessere", "Ergebnisse", "auf", "als", "das", "Intrazervikalgel", ";", "keine", "signifikanten", "Unterschiede", "ergaben", "sich", "in", "der", "Haeufigkeit", "uteriner", "Ueberstimulierungen", ",", "unerwuenschter", "maternaler", "Begleitwirkungen", ",", "der", "Sectiorate", "und", "im", "fetal", "outcome", "\"", ".", "\"", "Bei", "reifer", "Zervix", "erwiesen", "sich", "das", "2", "mg", "PGE2-Vaginalgel", "und", "die", "3", "mg", "PGE2-Vaginaltablette", "als", "aequieffektiv", ".", "Mit", "dem", "2", "mg", "PGE2-Vaginalgel", "steht", "eine", "effiziente", "Applikationsform", "fuer", "die", "Geburtseinleitung", "ab", "einem", "Bishop", "-", "Score", ">", "=3", "zur", "Verfuegung", "." ]	[ "umlsterm" ]
Effizienz is an umlsterm, Geburtseinleitung is an umlsterm, Muttermundsverhaeltnissen is an umlsterm, Geburtseinleitung is an umlsterm	PerinatalMedizin.80100081.ger.abstr_task1	Sentence: Im Rahmen einer prospektiven randomisierten Multicenterstudie wurde bei 796 Patientinnen die Effizienz der Geburtseinleitung mittels 2 mg PGE2-Vaginalgel vs. 0,5 mg Intrazervikalgel bei unreifer Zervix ( Bishop-Score 3-4 ) und von 2 mg PGE2-Vaginalgel vs. der 3 mg PGE2-Vaginaltablette bei reifer Zervix ( Bishop-Score 5-7 ) vergleichend untersucht . Bei unreifen Muttermundsverhaeltnissen wies das 2 mg PGE2-Vaginalgel hinsichtlich des Reifungseffekts , der medianen Induktionsgeburtsintervalle und der kumulativen Entbindungsraten/24 h signifikant bessere Ergebnisse auf als das Intrazervikalgel ; keine signifikanten Unterschiede ergaben sich in der Haeufigkeit uteriner Ueberstimulierungen , unerwuenschter maternaler Begleitwirkungen , der Sectiorate und im fetal outcome " . " Bei reifer Zervix erwiesen sich das 2 mg PGE2-Vaginalgel und die 3 mg PGE2-Vaginaltablette als aequieffektiv . Mit dem 2 mg PGE2-Vaginalgel steht eine effiziente Applikationsform fuer die Geburtseinleitung ab einem Bishop-Score > =3 zur Verfuegung . Instructions: please typing these entity words according to sentence: Effizienz, Geburtseinleitung, Muttermundsverhaeltnissen, Geburtseinleitung Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Im Rahmen einer prospektiven randomisierten Multicenterstudie wurde bei 796 Patientinnen die Effizienz der Geburtseinleitung mittels 2 mg PGE2-Vaginalgel vs. 0,5 mg Intrazervikalgel bei unreifer Zervix ( Bishop-Score 3-4 ) und von 2 mg PGE2-Vaginalgel vs. der 3 mg PGE2-Vaginaltablette bei reifer Zervix ( Bishop-Score 5-7 ) vergleichend untersucht . Bei unreifen Muttermundsverhaeltnissen wies das 2 mg PGE2-Vaginalgel hinsichtlich des Reifungseffekts , der medianen Induktionsgeburtsintervalle und der kumulativen Entbindungsraten/24 h signifikant bessere Ergebnisse auf als das Intrazervikalgel ; keine signifikanten Unterschiede ergaben sich in der Haeufigkeit uteriner Ueberstimulierungen , unerwuenschter maternaler Begleitwirkungen , der Sectiorate und im fetal outcome " . " Bei reifer Zervix erwiesen sich das 2 mg PGE2-Vaginalgel und die 3 mg PGE2-Vaginaltablette als aequieffektiv . Mit dem 2 mg PGE2-Vaginalgel steht eine effiziente Applikationsform fuer die Geburtseinleitung ab einem Bishop-Score > =3 zur Verfuegung .	[ "Im", "Rahmen", "einer", "prospektiven", "randomisierten", "Multicenterstudie", "wurde", "bei", "796", "Patientinnen", "die", "Effizienz", "der", "Geburtseinleitung", "mittels", "2", "mg", "PGE2-Vaginalgel", "vs", ".", "0,5", "mg", "Intrazervikalgel", "bei", "unreifer", "Zervix", "(", "Bishop", "-", "Score", "3", "-", "4", ")", "und", "von", "2", "mg", "PGE2-Vaginalgel", "vs", ".", "der", "3", "mg", "PGE2-Vaginaltablette", "bei", "reifer", "Zervix", "(", "Bishop", "-", "Score", "5", "-", "7", ")", "vergleichend", "untersucht", ".", "Bei", "unreifen", "Muttermundsverhaeltnissen", "wies", "das", "2", "mg", "PGE2-Vaginalgel", "hinsichtlich", "des", "Reifungseffekts", ",", "der", "medianen", "Induktionsgeburtsintervalle", "und", "der", "kumulativen", "Entbindungsraten/24", "h", "signifikant", "bessere", "Ergebnisse", "auf", "als", "das", "Intrazervikalgel", ";", "keine", "signifikanten", "Unterschiede", "ergaben", "sich", "in", "der", "Haeufigkeit", "uteriner", "Ueberstimulierungen", ",", "unerwuenschter", "maternaler", "Begleitwirkungen", ",", "der", "Sectiorate", "und", "im", "fetal", "outcome", "\"", ".", "\"", "Bei", "reifer", "Zervix", "erwiesen", "sich", "das", "2", "mg", "PGE2-Vaginalgel", "und", "die", "3", "mg", "PGE2-Vaginaltablette", "als", "aequieffektiv", ".", "Mit", "dem", "2", "mg", "PGE2-Vaginalgel", "steht", "eine", "effiziente", "Applikationsform", "fuer", "die", "Geburtseinleitung", "ab", "einem", "Bishop", "-", "Score", ">", "=3", "zur", "Verfuegung", "." ]	[ "umlsterm" ]
Effizienz, Geburtseinleitung, Muttermundsverhaeltnissen, Geburtseinleitung	PerinatalMedizin.80100081.ger.abstr_task2	Sentence: Im Rahmen einer prospektiven randomisierten Multicenterstudie wurde bei 796 Patientinnen die Effizienz der Geburtseinleitung mittels 2 mg PGE2-Vaginalgel vs. 0,5 mg Intrazervikalgel bei unreifer Zervix ( Bishop-Score 3-4 ) und von 2 mg PGE2-Vaginalgel vs. der 3 mg PGE2-Vaginaltablette bei reifer Zervix ( Bishop-Score 5-7 ) vergleichend untersucht . Bei unreifen Muttermundsverhaeltnissen wies das 2 mg PGE2-Vaginalgel hinsichtlich des Reifungseffekts , der medianen Induktionsgeburtsintervalle und der kumulativen Entbindungsraten/24 h signifikant bessere Ergebnisse auf als das Intrazervikalgel ; keine signifikanten Unterschiede ergaben sich in der Haeufigkeit uteriner Ueberstimulierungen , unerwuenschter maternaler Begleitwirkungen , der Sectiorate und im fetal outcome " . " Bei reifer Zervix erwiesen sich das 2 mg PGE2-Vaginalgel und die 3 mg PGE2-Vaginaltablette als aequieffektiv . Mit dem 2 mg PGE2-Vaginalgel steht eine effiziente Applikationsform fuer die Geburtseinleitung ab einem Bishop-Score > =3 zur Verfuegung . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Im Rahmen einer prospektiven randomisierten Multicenterstudie wurde bei 796 Patientinnen die Effizienz der Geburtseinleitung mittels 2 mg PGE2-Vaginalgel vs. 0,5 mg Intrazervikalgel bei unreifer Zervix ( Bishop-Score 3-4 ) und von 2 mg PGE2-Vaginalgel vs. der 3 mg PGE2-Vaginaltablette bei reifer Zervix ( Bishop-Score 5-7 ) vergleichend untersucht . Bei unreifen Muttermundsverhaeltnissen wies das 2 mg PGE2-Vaginalgel hinsichtlich des Reifungseffekts , der medianen Induktionsgeburtsintervalle und der kumulativen Entbindungsraten/24 h signifikant bessere Ergebnisse auf als das Intrazervikalgel ; keine signifikanten Unterschiede ergaben sich in der Haeufigkeit uteriner Ueberstimulierungen , unerwuenschter maternaler Begleitwirkungen , der Sectiorate und im fetal outcome " . " Bei reifer Zervix erwiesen sich das 2 mg PGE2-Vaginalgel und die 3 mg PGE2-Vaginaltablette als aequieffektiv . Mit dem 2 mg PGE2-Vaginalgel steht eine effiziente Applikationsform fuer die Geburtseinleitung ab einem Bishop-Score > =3 zur Verfuegung .	[ "Im", "Rahmen", "einer", "prospektiven", "randomisierten", "Multicenterstudie", "wurde", "bei", "796", "Patientinnen", "die", "Effizienz", "der", "Geburtseinleitung", "mittels", "2", "mg", "PGE2-Vaginalgel", "vs", ".", "0,5", "mg", "Intrazervikalgel", "bei", "unreifer", "Zervix", "(", "Bishop", "-", "Score", "3", "-", "4", ")", "und", "von", "2", "mg", "PGE2-Vaginalgel", "vs", ".", "der", "3", "mg", "PGE2-Vaginaltablette", "bei", "reifer", "Zervix", "(", "Bishop", "-", "Score", "5", "-", "7", ")", "vergleichend", "untersucht", ".", "Bei", "unreifen", "Muttermundsverhaeltnissen", "wies", "das", "2", "mg", "PGE2-Vaginalgel", "hinsichtlich", "des", "Reifungseffekts", ",", "der", "medianen", "Induktionsgeburtsintervalle", "und", "der", "kumulativen", "Entbindungsraten/24", "h", "signifikant", "bessere", "Ergebnisse", "auf", "als", "das", "Intrazervikalgel", ";", "keine", "signifikanten", "Unterschiede", "ergaben", "sich", "in", "der", "Haeufigkeit", "uteriner", "Ueberstimulierungen", ",", "unerwuenschter", "maternaler", "Begleitwirkungen", ",", "der", "Sectiorate", "und", "im", "fetal", "outcome", "\"", ".", "\"", "Bei", "reifer", "Zervix", "erwiesen", "sich", "das", "2", "mg", "PGE2-Vaginalgel", "und", "die", "3", "mg", "PGE2-Vaginaltablette", "als", "aequieffektiv", ".", "Mit", "dem", "2", "mg", "PGE2-Vaginalgel", "steht", "eine", "effiziente", "Applikationsform", "fuer", "die", "Geburtseinleitung", "ab", "einem", "Bishop", "-", "Score", ">", "=3", "zur", "Verfuegung", "." ]	[ "umlsterm" ]
cystitis is an umlsterm, toxic is an umlsterm, complication is an umlsterm, chemotherapy is an umlsterm, cyclophosphamide is an umlsterm, incidence is an umlsterm, bone marrow transplantation is an umlsterm, bladder is an umlsterm, hematuria is an umlsterm, clot is an umlsterm, bladder is an umlsterm, preventive measures is an umlsterm, Prevention is an umlsterm, incidence is an umlsterm, cystitis is an umlsterm, Treatment is an umlsterm, diuresis is an umlsterm, bladder is an umlsterm, irrigation is an umlsterm, cauterisation is an umlsterm, hemostyptic is an umlsterm, Embolisation is an umlsterm, vessels is an umlsterm, open is an umlsterm, surgery is an umlsterm	DerUrologeA.80370516.eng.abstr_task0	Sentence: Hemorrhagic cystitis is a well known toxic and often life-threatening complication from high-dose chemotherapy with cyclophosphamide . The incidence is particularly high after allogeneic bone marrow transplantation . The morphologic bladder wall changes are associated with gross hematuria , clot formation in the bladder and problems to control the bleeding in up to 70 % without preventive measures . Prevention is routinely done and can reduce but not obviate the incidence of hemorrhagic cystitis . Treatment is initiated by forced diuresis and continous bladder irrigation . When necessary endoscopic cauterisation of bleeding mucosal areas is combined with the instillation of hemostyptic agents . Embolisation of the pelvic vessels or open surgery to control the bleeding is indicated in selected cases in a life-threatening situation . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Hemorrhagic cystitis is a well known toxic and often life-threatening complication from high-dose chemotherapy with cyclophosphamide . The incidence is particularly high after allogeneic bone marrow transplantation . The morphologic bladder wall changes are associated with gross hematuria , clot formation in the bladder and problems to control the bleeding in up to 70 % without preventive measures . Prevention is routinely done and can reduce but not obviate the incidence of hemorrhagic cystitis . Treatment is initiated by forced diuresis and continous bladder irrigation . When necessary endoscopic cauterisation of bleeding mucosal areas is combined with the instillation of hemostyptic agents . Embolisation of the pelvic vessels or open surgery to control the bleeding is indicated in selected cases in a life-threatening situation .	[ "Hemorrhagic", "cystitis", "is", "a", "well", "known", "toxic", "and", "often", "life", "-", "threatening", "complication", "from", "high", "-", "dose", "chemotherapy", "with", "cyclophosphamide", ".", "The", "incidence", "is", "particularly", "high", "after", "allogeneic", "bone", "marrow", "transplantation", ".", "The", "morphologic", "bladder", "wall", "changes", "are", "associated", "with", "gross", "hematuria", ",", "clot", "formation", "in", "the", "bladder", "and", "problems", "to", "control", "the", "bleeding", "in", "up", "to", "70", "%", "without", "preventive", "measures", ".", "Prevention", "is", "routinely", "done", "and", "can", "reduce", "but", "not", "obviate", "the", "incidence", "of", "hemorrhagic", "cystitis", ".", "Treatment", "is", "initiated", "by", "forced", "diuresis", "and", "continous", "bladder", "irrigation", ".", "When", "necessary", "endoscopic", "cauterisation", "of", "bleeding", "mucosal", "areas", "is", "combined", "with", "the", "instillation", "of", "hemostyptic", "agents", ".", "Embolisation", "of", "the", "pelvic", "vessels", "or", "open", "surgery", "to", "control", "the", "bleeding", "is", "indicated", "in", "selected", "cases", "in", "a", "life", "-", "threatening", "situation", "." ]	[ "umlsterm" ]
cystitis is an umlsterm, toxic is an umlsterm, complication is an umlsterm, chemotherapy is an umlsterm, cyclophosphamide is an umlsterm, incidence is an umlsterm, bone marrow transplantation is an umlsterm, bladder is an umlsterm, hematuria is an umlsterm, clot is an umlsterm, bladder is an umlsterm, preventive measures is an umlsterm, Prevention is an umlsterm, incidence is an umlsterm, cystitis is an umlsterm, Treatment is an umlsterm, diuresis is an umlsterm, bladder is an umlsterm, irrigation is an umlsterm, cauterisation is an umlsterm, hemostyptic is an umlsterm, Embolisation is an umlsterm, vessels is an umlsterm, open is an umlsterm, surgery is an umlsterm	DerUrologeA.80370516.eng.abstr_task1	Sentence: Hemorrhagic cystitis is a well known toxic and often life-threatening complication from high-dose chemotherapy with cyclophosphamide . The incidence is particularly high after allogeneic bone marrow transplantation . The morphologic bladder wall changes are associated with gross hematuria , clot formation in the bladder and problems to control the bleeding in up to 70 % without preventive measures . Prevention is routinely done and can reduce but not obviate the incidence of hemorrhagic cystitis . Treatment is initiated by forced diuresis and continous bladder irrigation . When necessary endoscopic cauterisation of bleeding mucosal areas is combined with the instillation of hemostyptic agents . Embolisation of the pelvic vessels or open surgery to control the bleeding is indicated in selected cases in a life-threatening situation . Instructions: please typing these entity words according to sentence: cystitis, toxic, complication, chemotherapy, cyclophosphamide, incidence, bone marrow transplantation, bladder, hematuria, clot, bladder, preventive measures, Prevention, incidence, cystitis, Treatment, diuresis, bladder, irrigation, cauterisation, hemostyptic, Embolisation, vessels, open, surgery Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Hemorrhagic cystitis is a well known toxic and often life-threatening complication from high-dose chemotherapy with cyclophosphamide . The incidence is particularly high after allogeneic bone marrow transplantation . The morphologic bladder wall changes are associated with gross hematuria , clot formation in the bladder and problems to control the bleeding in up to 70 % without preventive measures . Prevention is routinely done and can reduce but not obviate the incidence of hemorrhagic cystitis . Treatment is initiated by forced diuresis and continous bladder irrigation . When necessary endoscopic cauterisation of bleeding mucosal areas is combined with the instillation of hemostyptic agents . Embolisation of the pelvic vessels or open surgery to control the bleeding is indicated in selected cases in a life-threatening situation .	[ "Hemorrhagic", "cystitis", "is", "a", "well", "known", "toxic", "and", "often", "life", "-", "threatening", "complication", "from", "high", "-", "dose", "chemotherapy", "with", "cyclophosphamide", ".", "The", "incidence", "is", "particularly", "high", "after", "allogeneic", "bone", "marrow", "transplantation", ".", "The", "morphologic", "bladder", "wall", "changes", "are", "associated", "with", "gross", "hematuria", ",", "clot", "formation", "in", "the", "bladder", "and", "problems", "to", "control", "the", "bleeding", "in", "up", "to", "70", "%", "without", "preventive", "measures", ".", "Prevention", "is", "routinely", "done", "and", "can", "reduce", "but", "not", "obviate", "the", "incidence", "of", "hemorrhagic", "cystitis", ".", "Treatment", "is", "initiated", "by", "forced", "diuresis", "and", "continous", "bladder", "irrigation", ".", "When", "necessary", "endoscopic", "cauterisation", "of", "bleeding", "mucosal", "areas", "is", "combined", "with", "the", "instillation", "of", "hemostyptic", "agents", ".", "Embolisation", "of", "the", "pelvic", "vessels", "or", "open", "surgery", "to", "control", "the", "bleeding", "is", "indicated", "in", "selected", "cases", "in", "a", "life", "-", "threatening", "situation", "." ]	[ "umlsterm" ]
cystitis, toxic, complication, chemotherapy, cyclophosphamide, incidence, bone marrow transplantation, bladder, hematuria, clot, bladder, preventive measures, Prevention, incidence, cystitis, Treatment, diuresis, bladder, irrigation, cauterisation, hemostyptic, Embolisation, vessels, open, surgery	DerUrologeA.80370516.eng.abstr_task2	Sentence: Hemorrhagic cystitis is a well known toxic and often life-threatening complication from high-dose chemotherapy with cyclophosphamide . The incidence is particularly high after allogeneic bone marrow transplantation . The morphologic bladder wall changes are associated with gross hematuria , clot formation in the bladder and problems to control the bleeding in up to 70 % without preventive measures . Prevention is routinely done and can reduce but not obviate the incidence of hemorrhagic cystitis . Treatment is initiated by forced diuresis and continous bladder irrigation . When necessary endoscopic cauterisation of bleeding mucosal areas is combined with the instillation of hemostyptic agents . Embolisation of the pelvic vessels or open surgery to control the bleeding is indicated in selected cases in a life-threatening situation . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Hemorrhagic cystitis is a well known toxic and often life-threatening complication from high-dose chemotherapy with cyclophosphamide . The incidence is particularly high after allogeneic bone marrow transplantation . The morphologic bladder wall changes are associated with gross hematuria , clot formation in the bladder and problems to control the bleeding in up to 70 % without preventive measures . Prevention is routinely done and can reduce but not obviate the incidence of hemorrhagic cystitis . Treatment is initiated by forced diuresis and continous bladder irrigation . When necessary endoscopic cauterisation of bleeding mucosal areas is combined with the instillation of hemostyptic agents . Embolisation of the pelvic vessels or open surgery to control the bleeding is indicated in selected cases in a life-threatening situation .	[ "Hemorrhagic", "cystitis", "is", "a", "well", "known", "toxic", "and", "often", "life", "-", "threatening", "complication", "from", "high", "-", "dose", "chemotherapy", "with", "cyclophosphamide", ".", "The", "incidence", "is", "particularly", "high", "after", "allogeneic", "bone", "marrow", "transplantation", ".", "The", "morphologic", "bladder", "wall", "changes", "are", "associated", "with", "gross", "hematuria", ",", "clot", "formation", "in", "the", "bladder", "and", "problems", "to", "control", "the", "bleeding", "in", "up", "to", "70", "%", "without", "preventive", "measures", ".", "Prevention", "is", "routinely", "done", "and", "can", "reduce", "but", "not", "obviate", "the", "incidence", "of", "hemorrhagic", "cystitis", ".", "Treatment", "is", "initiated", "by", "forced", "diuresis", "and", "continous", "bladder", "irrigation", ".", "When", "necessary", "endoscopic", "cauterisation", "of", "bleeding", "mucosal", "areas", "is", "combined", "with", "the", "instillation", "of", "hemostyptic", "agents", ".", "Embolisation", "of", "the", "pelvic", "vessels", "or", "open", "surgery", "to", "control", "the", "bleeding", "is", "indicated", "in", "selected", "cases", "in", "a", "life", "-", "threatening", "situation", "." ]	[ "umlsterm" ]
ketoprofen is a DRUG, Orudis is a BRAND, ketoprofen is a DRUG, Antacids is a GROUP, magnesium hydroxide is a DRUG, aluminum hydroxide is a DRUG, ketoprofen is a DRUG, Orudis is a BRAND, Aspirin is a BRAND, Ketoprofen is a DRUG, aspirin is a BRAND, aspirin is a BRAND, ketoprofen is a DRUG, ketoprofen is a DRUG, aspirin is a BRAND, aspirin is a BRAND, aspirin is a BRAND, ketoprofen is a DRUG, Diuretic is a GROUP, Hydrochlorothiazide is a DRUG, ketoprofen is a DRUG, hydrochlorothiazide is a DRUG, diuretics is a GROUP, Digoxin is a DRUG, ketoprofen is a DRUG, digoxin is a DRUG, ketoprofen is a DRUG, digoxin is a DRUG, Warfarin is a DRUG, ketoprofen is a DRUG, warfarin is a DRUG, warfarin is a DRUG, ketoprofen is a DRUG, ketoprofen is a DRUG, ketoprofen is a DRUG, warfarin is a DRUG, Probenecid is a DRUG, Probenecid is a DRUG, ketoprofen is a DRUG, ketoprofen is a DRUG, ketoprofen is a DRUG, probenecid is a DRUG, Methotrexate is a DRUG, Ketoprofen is a DRUG, NSAIDs is a GROUP, methotrexate is a DRUG, Lithium is a DRUG, Nonsteroidal anti - inflammatory agents is a GROUP, lithium is a DRUG, lithium is a DRUG, ketoprofen is a DRUG, lithium is a DRUG, Ketoprofen is a DRUG	Ketoprofen_ddi_task0	Sentence: The following drug interactions were studied with ketoprofen doses of 200 mg/day. The possibility of increased interaction should be kept in mind when Orudis doses greater than 50 mg as a single dose or 200 mg of ketoprofen per day are used concomitantly with highly bound drugs. 1. Antacids: Concomitant administration of magnesium hydroxide and aluminum hydroxide does not interfere with the rate or extent of the absorption of ketoprofen administered as Orudis. 2. Aspirin: Ketoprofen does not alter aspirin absorption; however, in a study of 12 normal subjects, concurrent administration of aspirin decreased ketoprofen protein binding and increased ketoprofen plasma clearance from 0.07 L/kg/h without aspirin to 0.11 L/kg/h with aspirin. The clinical significance of these changes has not been adequately studied. Therefore, concurrent use of aspirin and ketoprofen is not recommended. 3. Diuretic: Hydrochlorothiazide, given concomitantly with ketoprofen, produces a reduction in urinary potassium and chloride excretion compared to hydrochlorothiazide alone. Patients taking diuretics are at a greater risk of developing renal failure secondary to a decrease in renal blood flow caused by prostaglandin inhibition. 4. Digoxin: In a study in 12 patients with congestive heart failure where ketoprofen and digoxin were concomitantly administered, ketoprofen did not alter the serum levels of digoxin. 5. Warfarin: In a short-term controlled study in 14 normal volunteers, ketoprofen did not significantly interfere with the effect of warfarin on prothrombin time. Bleeding from a number of sites may be a complication of warfarin treatment and GI bleeding a complication of ketoprofen treatment. Because prostaglandina play an important role in hemostasis and ketoprofen has an effect on platelet function as well, concurent therapy with ketoprofen and warfarin requires close monitoring of patients on both drugs. 6. Probenecid: Probenecid increases both free and bound ketoprofen by reducing the plasma clearance of ketoprofen to about one-third, as well as decreasing its protein binding. Therefore, the combination of ketoprofen and probenecid is not recommended. 7. Methotrexate: Ketoprofen, like other NSAIDs, may cause changes in the elimination of methotrexate leading to elevated serum levels of the drug and increased toxicity. 8. Lithium: Nonsteroidal anti-inflammatory agents have been reported to increase steadystate plasma lithium levels. It is recommended that plasma lithium levels be monitored when ketoprofen is coadministered with lithium. DRUG/LABORATORY TEST INTERACTIONS: EFFECT ON BLOOD COAGULATION Ketoprofen decreases platelet adhesion and aggregation. Therefore, it can prolong bleeding time by approximately 3 to 4 minutes from baseline values. There is no significant change in platelet count, prothrombin time, partial thromboplastin time, or thrombin time. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GROUP, BRAND, DRUG	[ "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "B-DRUG", "I-DRUG", "O", "B-DRUG", "I-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "B-BRAND", "O", "O", "O", "B-BRAND", "O", "B-DRUG", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "B-DRUG", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "B-DRUG", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The following drug interactions were studied with ketoprofen doses of 200 mg/day. The possibility of increased interaction should be kept in mind when Orudis doses greater than 50 mg as a single dose or 200 mg of ketoprofen per day are used concomitantly with highly bound drugs. 1. Antacids: Concomitant administration of magnesium hydroxide and aluminum hydroxide does not interfere with the rate or extent of the absorption of ketoprofen administered as Orudis. 2. Aspirin: Ketoprofen does not alter aspirin absorption; however, in a study of 12 normal subjects, concurrent administration of aspirin decreased ketoprofen protein binding and increased ketoprofen plasma clearance from 0.07 L/kg/h without aspirin to 0.11 L/kg/h with aspirin. The clinical significance of these changes has not been adequately studied. Therefore, concurrent use of aspirin and ketoprofen is not recommended. 3. Diuretic: Hydrochlorothiazide, given concomitantly with ketoprofen, produces a reduction in urinary potassium and chloride excretion compared to hydrochlorothiazide alone. Patients taking diuretics are at a greater risk of developing renal failure secondary to a decrease in renal blood flow caused by prostaglandin inhibition. 4. Digoxin: In a study in 12 patients with congestive heart failure where ketoprofen and digoxin were concomitantly administered, ketoprofen did not alter the serum levels of digoxin. 5. Warfarin: In a short-term controlled study in 14 normal volunteers, ketoprofen did not significantly interfere with the effect of warfarin on prothrombin time. Bleeding from a number of sites may be a complication of warfarin treatment and GI bleeding a complication of ketoprofen treatment. Because prostaglandina play an important role in hemostasis and ketoprofen has an effect on platelet function as well, concurent therapy with ketoprofen and warfarin requires close monitoring of patients on both drugs. 6. Probenecid: Probenecid increases both free and bound ketoprofen by reducing the plasma clearance of ketoprofen to about one-third, as well as decreasing its protein binding. Therefore, the combination of ketoprofen and probenecid is not recommended. 7. Methotrexate: Ketoprofen, like other NSAIDs, may cause changes in the elimination of methotrexate leading to elevated serum levels of the drug and increased toxicity. 8. Lithium: Nonsteroidal anti-inflammatory agents have been reported to increase steadystate plasma lithium levels. It is recommended that plasma lithium levels be monitored when ketoprofen is coadministered with lithium. DRUG/LABORATORY TEST INTERACTIONS: EFFECT ON BLOOD COAGULATION Ketoprofen decreases platelet adhesion and aggregation. Therefore, it can prolong bleeding time by approximately 3 to 4 minutes from baseline values. There is no significant change in platelet count, prothrombin time, partial thromboplastin time, or thrombin time.	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ketoprofen is a DRUG, Orudis is a BRAND, ketoprofen is a DRUG, Antacids is a GROUP, magnesium hydroxide is a DRUG, aluminum hydroxide is a DRUG, ketoprofen is a DRUG, Orudis is a BRAND, Aspirin is a BRAND, Ketoprofen is a DRUG, aspirin is a BRAND, aspirin is a BRAND, ketoprofen is a DRUG, ketoprofen is a DRUG, aspirin is a BRAND, aspirin is a BRAND, aspirin is a BRAND, ketoprofen is a DRUG, Diuretic is a GROUP, Hydrochlorothiazide is a DRUG, ketoprofen is a DRUG, hydrochlorothiazide is a DRUG, diuretics is a GROUP, Digoxin is a DRUG, ketoprofen is a DRUG, digoxin is a DRUG, ketoprofen is a DRUG, digoxin is a DRUG, Warfarin is a DRUG, ketoprofen is a DRUG, warfarin is a DRUG, warfarin is a DRUG, ketoprofen is a DRUG, ketoprofen is a DRUG, ketoprofen is a DRUG, warfarin is a DRUG, Probenecid is a DRUG, Probenecid is a DRUG, ketoprofen is a DRUG, ketoprofen is a DRUG, ketoprofen is a DRUG, probenecid is a DRUG, Methotrexate is a DRUG, Ketoprofen is a DRUG, NSAIDs is a GROUP, methotrexate is a DRUG, Lithium is a DRUG, Nonsteroidal anti - inflammatory agents is a GROUP, lithium is a DRUG, lithium is a DRUG, ketoprofen is a DRUG, lithium is a DRUG, Ketoprofen is a DRUG	Ketoprofen_ddi_task1	Sentence: The following drug interactions were studied with ketoprofen doses of 200 mg/day. The possibility of increased interaction should be kept in mind when Orudis doses greater than 50 mg as a single dose or 200 mg of ketoprofen per day are used concomitantly with highly bound drugs. 1. Antacids: Concomitant administration of magnesium hydroxide and aluminum hydroxide does not interfere with the rate or extent of the absorption of ketoprofen administered as Orudis. 2. Aspirin: Ketoprofen does not alter aspirin absorption; however, in a study of 12 normal subjects, concurrent administration of aspirin decreased ketoprofen protein binding and increased ketoprofen plasma clearance from 0.07 L/kg/h without aspirin to 0.11 L/kg/h with aspirin. The clinical significance of these changes has not been adequately studied. Therefore, concurrent use of aspirin and ketoprofen is not recommended. 3. Diuretic: Hydrochlorothiazide, given concomitantly with ketoprofen, produces a reduction in urinary potassium and chloride excretion compared to hydrochlorothiazide alone. Patients taking diuretics are at a greater risk of developing renal failure secondary to a decrease in renal blood flow caused by prostaglandin inhibition. 4. Digoxin: In a study in 12 patients with congestive heart failure where ketoprofen and digoxin were concomitantly administered, ketoprofen did not alter the serum levels of digoxin. 5. Warfarin: In a short-term controlled study in 14 normal volunteers, ketoprofen did not significantly interfere with the effect of warfarin on prothrombin time. Bleeding from a number of sites may be a complication of warfarin treatment and GI bleeding a complication of ketoprofen treatment. Because prostaglandina play an important role in hemostasis and ketoprofen has an effect on platelet function as well, concurent therapy with ketoprofen and warfarin requires close monitoring of patients on both drugs. 6. Probenecid: Probenecid increases both free and bound ketoprofen by reducing the plasma clearance of ketoprofen to about one-third, as well as decreasing its protein binding. Therefore, the combination of ketoprofen and probenecid is not recommended. 7. Methotrexate: Ketoprofen, like other NSAIDs, may cause changes in the elimination of methotrexate leading to elevated serum levels of the drug and increased toxicity. 8. Lithium: Nonsteroidal anti-inflammatory agents have been reported to increase steadystate plasma lithium levels. It is recommended that plasma lithium levels be monitored when ketoprofen is coadministered with lithium. DRUG/LABORATORY TEST INTERACTIONS: EFFECT ON BLOOD COAGULATION Ketoprofen decreases platelet adhesion and aggregation. Therefore, it can prolong bleeding time by approximately 3 to 4 minutes from baseline values. There is no significant change in platelet count, prothrombin time, partial thromboplastin time, or thrombin time. Instructions: please typing these entity words according to sentence: ketoprofen, Orudis, ketoprofen, Antacids, magnesium hydroxide, aluminum hydroxide, ketoprofen, Orudis, Aspirin, Ketoprofen, aspirin, aspirin, ketoprofen, ketoprofen, aspirin, aspirin, aspirin, ketoprofen, Diuretic, Hydrochlorothiazide, ketoprofen, hydrochlorothiazide, diuretics, Digoxin, ketoprofen, digoxin, ketoprofen, digoxin, Warfarin, ketoprofen, warfarin, warfarin, ketoprofen, ketoprofen, ketoprofen, warfarin, Probenecid, Probenecid, ketoprofen, ketoprofen, ketoprofen, probenecid, Methotrexate, Ketoprofen, NSAIDs, methotrexate, Lithium, Nonsteroidal anti - inflammatory agents, lithium, lithium, ketoprofen, lithium, Ketoprofen Options: GROUP, BRAND, DRUG	[ "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "B-DRUG", "I-DRUG", "O", "B-DRUG", "I-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "B-BRAND", "O", "O", "O", "B-BRAND", "O", "B-DRUG", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "B-DRUG", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "B-DRUG", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The following drug interactions were studied with ketoprofen doses of 200 mg/day. The possibility of increased interaction should be kept in mind when Orudis doses greater than 50 mg as a single dose or 200 mg of ketoprofen per day are used concomitantly with highly bound drugs. 1. Antacids: Concomitant administration of magnesium hydroxide and aluminum hydroxide does not interfere with the rate or extent of the absorption of ketoprofen administered as Orudis. 2. Aspirin: Ketoprofen does not alter aspirin absorption; however, in a study of 12 normal subjects, concurrent administration of aspirin decreased ketoprofen protein binding and increased ketoprofen plasma clearance from 0.07 L/kg/h without aspirin to 0.11 L/kg/h with aspirin. The clinical significance of these changes has not been adequately studied. Therefore, concurrent use of aspirin and ketoprofen is not recommended. 3. Diuretic: Hydrochlorothiazide, given concomitantly with ketoprofen, produces a reduction in urinary potassium and chloride excretion compared to hydrochlorothiazide alone. Patients taking diuretics are at a greater risk of developing renal failure secondary to a decrease in renal blood flow caused by prostaglandin inhibition. 4. Digoxin: In a study in 12 patients with congestive heart failure where ketoprofen and digoxin were concomitantly administered, ketoprofen did not alter the serum levels of digoxin. 5. Warfarin: In a short-term controlled study in 14 normal volunteers, ketoprofen did not significantly interfere with the effect of warfarin on prothrombin time. Bleeding from a number of sites may be a complication of warfarin treatment and GI bleeding a complication of ketoprofen treatment. Because prostaglandina play an important role in hemostasis and ketoprofen has an effect on platelet function as well, concurent therapy with ketoprofen and warfarin requires close monitoring of patients on both drugs. 6. Probenecid: Probenecid increases both free and bound ketoprofen by reducing the plasma clearance of ketoprofen to about one-third, as well as decreasing its protein binding. Therefore, the combination of ketoprofen and probenecid is not recommended. 7. Methotrexate: Ketoprofen, like other NSAIDs, may cause changes in the elimination of methotrexate leading to elevated serum levels of the drug and increased toxicity. 8. Lithium: Nonsteroidal anti-inflammatory agents have been reported to increase steadystate plasma lithium levels. It is recommended that plasma lithium levels be monitored when ketoprofen is coadministered with lithium. DRUG/LABORATORY TEST INTERACTIONS: EFFECT ON BLOOD COAGULATION Ketoprofen decreases platelet adhesion and aggregation. Therefore, it can prolong bleeding time by approximately 3 to 4 minutes from baseline values. There is no significant change in platelet count, prothrombin time, partial thromboplastin time, or thrombin time.	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ketoprofen, Orudis, ketoprofen, Antacids, magnesium hydroxide, aluminum hydroxide, ketoprofen, Orudis, Aspirin, Ketoprofen, aspirin, aspirin, ketoprofen, ketoprofen, aspirin, aspirin, aspirin, ketoprofen, Diuretic, Hydrochlorothiazide, ketoprofen, hydrochlorothiazide, diuretics, Digoxin, ketoprofen, digoxin, ketoprofen, digoxin, Warfarin, ketoprofen, warfarin, warfarin, ketoprofen, ketoprofen, ketoprofen, warfarin, Probenecid, Probenecid, ketoprofen, ketoprofen, ketoprofen, probenecid, Methotrexate, Ketoprofen, NSAIDs, methotrexate, Lithium, Nonsteroidal anti - inflammatory agents, lithium, lithium, ketoprofen, lithium, Ketoprofen	Ketoprofen_ddi_task2	Sentence: The following drug interactions were studied with ketoprofen doses of 200 mg/day. The possibility of increased interaction should be kept in mind when Orudis doses greater than 50 mg as a single dose or 200 mg of ketoprofen per day are used concomitantly with highly bound drugs. 1. Antacids: Concomitant administration of magnesium hydroxide and aluminum hydroxide does not interfere with the rate or extent of the absorption of ketoprofen administered as Orudis. 2. Aspirin: Ketoprofen does not alter aspirin absorption; however, in a study of 12 normal subjects, concurrent administration of aspirin decreased ketoprofen protein binding and increased ketoprofen plasma clearance from 0.07 L/kg/h without aspirin to 0.11 L/kg/h with aspirin. The clinical significance of these changes has not been adequately studied. Therefore, concurrent use of aspirin and ketoprofen is not recommended. 3. Diuretic: Hydrochlorothiazide, given concomitantly with ketoprofen, produces a reduction in urinary potassium and chloride excretion compared to hydrochlorothiazide alone. Patients taking diuretics are at a greater risk of developing renal failure secondary to a decrease in renal blood flow caused by prostaglandin inhibition. 4. Digoxin: In a study in 12 patients with congestive heart failure where ketoprofen and digoxin were concomitantly administered, ketoprofen did not alter the serum levels of digoxin. 5. Warfarin: In a short-term controlled study in 14 normal volunteers, ketoprofen did not significantly interfere with the effect of warfarin on prothrombin time. Bleeding from a number of sites may be a complication of warfarin treatment and GI bleeding a complication of ketoprofen treatment. Because prostaglandina play an important role in hemostasis and ketoprofen has an effect on platelet function as well, concurent therapy with ketoprofen and warfarin requires close monitoring of patients on both drugs. 6. Probenecid: Probenecid increases both free and bound ketoprofen by reducing the plasma clearance of ketoprofen to about one-third, as well as decreasing its protein binding. Therefore, the combination of ketoprofen and probenecid is not recommended. 7. Methotrexate: Ketoprofen, like other NSAIDs, may cause changes in the elimination of methotrexate leading to elevated serum levels of the drug and increased toxicity. 8. Lithium: Nonsteroidal anti-inflammatory agents have been reported to increase steadystate plasma lithium levels. It is recommended that plasma lithium levels be monitored when ketoprofen is coadministered with lithium. DRUG/LABORATORY TEST INTERACTIONS: EFFECT ON BLOOD COAGULATION Ketoprofen decreases platelet adhesion and aggregation. Therefore, it can prolong bleeding time by approximately 3 to 4 minutes from baseline values. There is no significant change in platelet count, prothrombin time, partial thromboplastin time, or thrombin time. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "B-DRUG", "I-DRUG", "O", "B-DRUG", "I-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "B-BRAND", "O", "O", "O", "B-BRAND", "O", "B-DRUG", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "B-DRUG", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "B-GROUP", "O", "B-DRUG", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-DRUG", "O", "O", "O", "B-GROUP", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "B-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "I-GROUP", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DRUG", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The following drug interactions were studied with ketoprofen doses of 200 mg/day. The possibility of increased interaction should be kept in mind when Orudis doses greater than 50 mg as a single dose or 200 mg of ketoprofen per day are used concomitantly with highly bound drugs. 1. Antacids: Concomitant administration of magnesium hydroxide and aluminum hydroxide does not interfere with the rate or extent of the absorption of ketoprofen administered as Orudis. 2. Aspirin: Ketoprofen does not alter aspirin absorption; however, in a study of 12 normal subjects, concurrent administration of aspirin decreased ketoprofen protein binding and increased ketoprofen plasma clearance from 0.07 L/kg/h without aspirin to 0.11 L/kg/h with aspirin. The clinical significance of these changes has not been adequately studied. Therefore, concurrent use of aspirin and ketoprofen is not recommended. 3. Diuretic: Hydrochlorothiazide, given concomitantly with ketoprofen, produces a reduction in urinary potassium and chloride excretion compared to hydrochlorothiazide alone. Patients taking diuretics are at a greater risk of developing renal failure secondary to a decrease in renal blood flow caused by prostaglandin inhibition. 4. Digoxin: In a study in 12 patients with congestive heart failure where ketoprofen and digoxin were concomitantly administered, ketoprofen did not alter the serum levels of digoxin. 5. Warfarin: In a short-term controlled study in 14 normal volunteers, ketoprofen did not significantly interfere with the effect of warfarin on prothrombin time. Bleeding from a number of sites may be a complication of warfarin treatment and GI bleeding a complication of ketoprofen treatment. Because prostaglandina play an important role in hemostasis and ketoprofen has an effect on platelet function as well, concurent therapy with ketoprofen and warfarin requires close monitoring of patients on both drugs. 6. Probenecid: Probenecid increases both free and bound ketoprofen by reducing the plasma clearance of ketoprofen to about one-third, as well as decreasing its protein binding. Therefore, the combination of ketoprofen and probenecid is not recommended. 7. Methotrexate: Ketoprofen, like other NSAIDs, may cause changes in the elimination of methotrexate leading to elevated serum levels of the drug and increased toxicity. 8. Lithium: Nonsteroidal anti-inflammatory agents have been reported to increase steadystate plasma lithium levels. It is recommended that plasma lithium levels be monitored when ketoprofen is coadministered with lithium. DRUG/LABORATORY TEST INTERACTIONS: EFFECT ON BLOOD COAGULATION Ketoprofen decreases platelet adhesion and aggregation. Therefore, it can prolong bleeding time by approximately 3 to 4 minutes from baseline values. There is no significant change in platelet count, prothrombin time, partial thromboplastin time, or thrombin time.	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FPLC is an assay, auxilin is a protein, Hsc70 is a protein, auxilin is a protein, Hsc70 is a protein	1.0alpha7.train.1121_task0	Sentence: However, it did not do so catalytically because FPLC showed that auxilin remained bound to polymerized Hsc70 at a 1:1 molar ratio of auxilin to Hsc70. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: assay, protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-assay", "O", "O", "B-protein", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "B-protein", "O", "B-protein", "O" ]	However, it did not do so catalytically because FPLC showed that auxilin remained bound to polymerized Hsc70 at a 1:1 molar ratio of auxilin to Hsc70.	[ "However", ",", "it", "did", "not", "do", "so", "catalytically", "because", "FPLC", "showed", "that", "auxilin", "remained", "bound", "to", "polymerized", "Hsc70", "at", "a", "1:1", "molar", "ratio", "of", "auxilin", "to", "Hsc70", "." ]	[ "protein", "assay" ]
FPLC is an assay, auxilin is a protein, Hsc70 is a protein, auxilin is a protein, Hsc70 is a protein	1.0alpha7.train.1121_task1	Sentence: However, it did not do so catalytically because FPLC showed that auxilin remained bound to polymerized Hsc70 at a 1:1 molar ratio of auxilin to Hsc70. Instructions: please typing these entity words according to sentence: FPLC, auxilin, Hsc70, auxilin, Hsc70 Options: assay, protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-assay", "O", "O", "B-protein", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "B-protein", "O", "B-protein", "O" ]	However, it did not do so catalytically because FPLC showed that auxilin remained bound to polymerized Hsc70 at a 1:1 molar ratio of auxilin to Hsc70.	[ "However", ",", "it", "did", "not", "do", "so", "catalytically", "because", "FPLC", "showed", "that", "auxilin", "remained", "bound", "to", "polymerized", "Hsc70", "at", "a", "1:1", "molar", "ratio", "of", "auxilin", "to", "Hsc70", "." ]	[ "protein", "assay" ]
FPLC, auxilin, Hsc70, auxilin, Hsc70	1.0alpha7.train.1121_task2	Sentence: However, it did not do so catalytically because FPLC showed that auxilin remained bound to polymerized Hsc70 at a 1:1 molar ratio of auxilin to Hsc70. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-assay", "O", "O", "B-protein", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "B-protein", "O", "B-protein", "O" ]	However, it did not do so catalytically because FPLC showed that auxilin remained bound to polymerized Hsc70 at a 1:1 molar ratio of auxilin to Hsc70.	[ "However", ",", "it", "did", "not", "do", "so", "catalytically", "because", "FPLC", "showed", "that", "auxilin", "remained", "bound", "to", "polymerized", "Hsc70", "at", "a", "1:1", "molar", "ratio", "of", "auxilin", "to", "Hsc70", "." ]	[ "protein", "assay" ]
prevalence is an umlsterm, symptoms is an umlsterm, disorders is an umlsterm, patients is an umlsterm, differential diagnosis is an umlsterm, disorders is an umlsterm, symptoms is an umlsterm, psychotic is an umlsterm, secondary is an umlsterm, neurologic manifestations is an umlsterm, nervous is an umlsterm, infections is an umlsterm, lymphoma is an umlsterm, findings is an umlsterm, differential diagnosis is an umlsterm, identification is an umlsterm, psychiatric disorders is an umlsterm, Secondary is an umlsterm, neurologic manifestations is an umlsterm, psychosis is an umlsterm, brain is an umlsterm, imaging is an umlsterm, MRI is an umlsterm, analysis is an umlsterm, cerebrospinal fluid is an umlsterm, emergency situations is an umlsterm, law is an umlsterm, regulations is an umlsterm, patients is an umlsterm, case reports is an umlsterm	DerNervenarzt.00710404.eng.abstr_task0	Sentence: The prevalence of psychiatric symptoms and disorders in HIV-infected patients is high . The differential diagnosis includes psychoreactive disorders , acute psychiatric symptoms of an HIV-associated encephalopathy , and symptomatic psychotic illnesses due to secondary neurologic manifestations such as opportunistic central nervous infections and intracerebral lymphoma . Clinical aspects and psychopathological findings are not sufficient for differential diagnosis and identification of primarily psychiatric disorders . Secondary neurologic manifestations causing a symptomatic psychosis must be excluded as soon as possible by brain imaging ( CT , MRI ) and analysis of the cerebrospinal fluid . In emergency situations , however , German law imposes strict regulations , especially in the case of sectioned patients . These medical and medicolegal questions are illustrated by case reports and propositions for an effective strategy are made . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The prevalence of psychiatric symptoms and disorders in HIV-infected patients is high . The differential diagnosis includes psychoreactive disorders , acute psychiatric symptoms of an HIV-associated encephalopathy , and symptomatic psychotic illnesses due to secondary neurologic manifestations such as opportunistic central nervous infections and intracerebral lymphoma . Clinical aspects and psychopathological findings are not sufficient for differential diagnosis and identification of primarily psychiatric disorders . Secondary neurologic manifestations causing a symptomatic psychosis must be excluded as soon as possible by brain imaging ( CT , MRI ) and analysis of the cerebrospinal fluid . In emergency situations , however , German law imposes strict regulations , especially in the case of sectioned patients . These medical and medicolegal questions are illustrated by case reports and propositions for an effective strategy are made .	[ "The", "prevalence", "of", "psychiatric", "symptoms", "and", "disorders", "in", "HIV", "-", "infected", "patients", "is", "high", ".", "The", "differential", "diagnosis", "includes", "psychoreactive", "disorders", ",", "acute", "psychiatric", "symptoms", "of", "an", "HIV", "-", "associated", "encephalopathy", ",", "and", "symptomatic", "psychotic", "illnesses", "due", "to", "secondary", "neurologic", "manifestations", "such", "as", "opportunistic", "central", "nervous", "infections", "and", "intracerebral", "lymphoma", ".", "Clinical", "aspects", "and", "psychopathological", "findings", "are", "not", "sufficient", "for", "differential", "diagnosis", "and", "identification", "of", "primarily", "psychiatric", "disorders", ".", "Secondary", "neurologic", "manifestations", "causing", "a", "symptomatic", "psychosis", "must", "be", "excluded", "as", "soon", "as", "possible", "by", "brain", "imaging", "(", "CT", ",", "MRI", ")", "and", "analysis", "of", "the", "cerebrospinal", "fluid", ".", "In", "emergency", "situations", ",", "however", ",", "German", "law", "imposes", "strict", "regulations", ",", "especially", "in", "the", "case", "of", "sectioned", "patients", ".", "These", "medical", "and", "medicolegal", "questions", "are", "illustrated", "by", "case", "reports", "and", "propositions", "for", "an", "effective", "strategy", "are", "made", "." ]	[ "umlsterm" ]
prevalence is an umlsterm, symptoms is an umlsterm, disorders is an umlsterm, patients is an umlsterm, differential diagnosis is an umlsterm, disorders is an umlsterm, symptoms is an umlsterm, psychotic is an umlsterm, secondary is an umlsterm, neurologic manifestations is an umlsterm, nervous is an umlsterm, infections is an umlsterm, lymphoma is an umlsterm, findings is an umlsterm, differential diagnosis is an umlsterm, identification is an umlsterm, psychiatric disorders is an umlsterm, Secondary is an umlsterm, neurologic manifestations is an umlsterm, psychosis is an umlsterm, brain is an umlsterm, imaging is an umlsterm, MRI is an umlsterm, analysis is an umlsterm, cerebrospinal fluid is an umlsterm, emergency situations is an umlsterm, law is an umlsterm, regulations is an umlsterm, patients is an umlsterm, case reports is an umlsterm	DerNervenarzt.00710404.eng.abstr_task1	Sentence: The prevalence of psychiatric symptoms and disorders in HIV-infected patients is high . The differential diagnosis includes psychoreactive disorders , acute psychiatric symptoms of an HIV-associated encephalopathy , and symptomatic psychotic illnesses due to secondary neurologic manifestations such as opportunistic central nervous infections and intracerebral lymphoma . Clinical aspects and psychopathological findings are not sufficient for differential diagnosis and identification of primarily psychiatric disorders . Secondary neurologic manifestations causing a symptomatic psychosis must be excluded as soon as possible by brain imaging ( CT , MRI ) and analysis of the cerebrospinal fluid . In emergency situations , however , German law imposes strict regulations , especially in the case of sectioned patients . These medical and medicolegal questions are illustrated by case reports and propositions for an effective strategy are made . Instructions: please typing these entity words according to sentence: prevalence, symptoms, disorders, patients, differential diagnosis, disorders, symptoms, psychotic, secondary, neurologic manifestations, nervous, infections, lymphoma, findings, differential diagnosis, identification, psychiatric disorders, Secondary, neurologic manifestations, psychosis, brain, imaging, MRI, analysis, cerebrospinal fluid, emergency situations, law, regulations, patients, case reports Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The prevalence of psychiatric symptoms and disorders in HIV-infected patients is high . The differential diagnosis includes psychoreactive disorders , acute psychiatric symptoms of an HIV-associated encephalopathy , and symptomatic psychotic illnesses due to secondary neurologic manifestations such as opportunistic central nervous infections and intracerebral lymphoma . Clinical aspects and psychopathological findings are not sufficient for differential diagnosis and identification of primarily psychiatric disorders . Secondary neurologic manifestations causing a symptomatic psychosis must be excluded as soon as possible by brain imaging ( CT , MRI ) and analysis of the cerebrospinal fluid . In emergency situations , however , German law imposes strict regulations , especially in the case of sectioned patients . These medical and medicolegal questions are illustrated by case reports and propositions for an effective strategy are made .	[ "The", "prevalence", "of", "psychiatric", "symptoms", "and", "disorders", "in", "HIV", "-", "infected", "patients", "is", "high", ".", "The", "differential", "diagnosis", "includes", "psychoreactive", "disorders", ",", "acute", "psychiatric", "symptoms", "of", "an", "HIV", "-", "associated", "encephalopathy", ",", "and", "symptomatic", "psychotic", "illnesses", "due", "to", "secondary", "neurologic", "manifestations", "such", "as", "opportunistic", "central", "nervous", "infections", "and", "intracerebral", "lymphoma", ".", "Clinical", "aspects", "and", "psychopathological", "findings", "are", "not", "sufficient", "for", "differential", "diagnosis", "and", "identification", "of", "primarily", "psychiatric", "disorders", ".", "Secondary", "neurologic", "manifestations", "causing", "a", "symptomatic", "psychosis", "must", "be", "excluded", "as", "soon", "as", "possible", "by", "brain", "imaging", "(", "CT", ",", "MRI", ")", "and", "analysis", "of", "the", "cerebrospinal", "fluid", ".", "In", "emergency", "situations", ",", "however", ",", "German", "law", "imposes", "strict", "regulations", ",", "especially", "in", "the", "case", "of", "sectioned", "patients", ".", "These", "medical", "and", "medicolegal", "questions", "are", "illustrated", "by", "case", "reports", "and", "propositions", "for", "an", "effective", "strategy", "are", "made", "." ]	[ "umlsterm" ]
prevalence, symptoms, disorders, patients, differential diagnosis, disorders, symptoms, psychotic, secondary, neurologic manifestations, nervous, infections, lymphoma, findings, differential diagnosis, identification, psychiatric disorders, Secondary, neurologic manifestations, psychosis, brain, imaging, MRI, analysis, cerebrospinal fluid, emergency situations, law, regulations, patients, case reports	DerNervenarzt.00710404.eng.abstr_task2	Sentence: The prevalence of psychiatric symptoms and disorders in HIV-infected patients is high . The differential diagnosis includes psychoreactive disorders , acute psychiatric symptoms of an HIV-associated encephalopathy , and symptomatic psychotic illnesses due to secondary neurologic manifestations such as opportunistic central nervous infections and intracerebral lymphoma . Clinical aspects and psychopathological findings are not sufficient for differential diagnosis and identification of primarily psychiatric disorders . Secondary neurologic manifestations causing a symptomatic psychosis must be excluded as soon as possible by brain imaging ( CT , MRI ) and analysis of the cerebrospinal fluid . In emergency situations , however , German law imposes strict regulations , especially in the case of sectioned patients . These medical and medicolegal questions are illustrated by case reports and propositions for an effective strategy are made . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The prevalence of psychiatric symptoms and disorders in HIV-infected patients is high . The differential diagnosis includes psychoreactive disorders , acute psychiatric symptoms of an HIV-associated encephalopathy , and symptomatic psychotic illnesses due to secondary neurologic manifestations such as opportunistic central nervous infections and intracerebral lymphoma . Clinical aspects and psychopathological findings are not sufficient for differential diagnosis and identification of primarily psychiatric disorders . Secondary neurologic manifestations causing a symptomatic psychosis must be excluded as soon as possible by brain imaging ( CT , MRI ) and analysis of the cerebrospinal fluid . In emergency situations , however , German law imposes strict regulations , especially in the case of sectioned patients . These medical and medicolegal questions are illustrated by case reports and propositions for an effective strategy are made .	[ "The", "prevalence", "of", "psychiatric", "symptoms", "and", "disorders", "in", "HIV", "-", "infected", "patients", "is", "high", ".", "The", "differential", "diagnosis", "includes", "psychoreactive", "disorders", ",", "acute", "psychiatric", "symptoms", "of", "an", "HIV", "-", "associated", "encephalopathy", ",", "and", "symptomatic", "psychotic", "illnesses", "due", "to", "secondary", "neurologic", "manifestations", "such", "as", "opportunistic", "central", "nervous", "infections", "and", "intracerebral", "lymphoma", ".", "Clinical", "aspects", "and", "psychopathological", "findings", "are", "not", "sufficient", "for", "differential", "diagnosis", "and", "identification", "of", "primarily", "psychiatric", "disorders", ".", "Secondary", "neurologic", "manifestations", "causing", "a", "symptomatic", "psychosis", "must", "be", "excluded", "as", "soon", "as", "possible", "by", "brain", "imaging", "(", "CT", ",", "MRI", ")", "and", "analysis", "of", "the", "cerebrospinal", "fluid", ".", "In", "emergency", "situations", ",", "however", ",", "German", "law", "imposes", "strict", "regulations", ",", "especially", "in", "the", "case", "of", "sectioned", "patients", ".", "These", "medical", "and", "medicolegal", "questions", "are", "illustrated", "by", "case", "reports", "and", "propositions", "for", "an", "effective", "strategy", "are", "made", "." ]	[ "umlsterm" ]
Bronchial carcinoma is a Participant_Condition, quality of survival is a Outcome_Mortality, Forty - eight is a Participant_Sample-size, bronchial carcinoma is a Participant_Condition, radiotherapy is a Intervention_Physical, chemotherapy ( cyclophosphamide ) is a Intervention_Pharmacological, placebo is a Intervention_Control, survival time is a Outcome_Mortality, median survival time is a Outcome_Mortality, median total sum of vitagram points is a Outcome_Other, median sum of vitagram points is a Outcome_Other	74012_task0	Sentence: Bronchial carcinoma . II . Quantitative measurements of the quality of survival . A prospective randomized study of the result of therapy in inoperable patients with advanced disease . Forty-eight bronchial carcinoma patients in clinicoanatomical stage 4 of the disease ( advanced disease ) were randomly assigned to groups for radiotherapy , chemotherapy ( cyclophosphamide ) and placebo treatment , respectively . The results were assessed by the survival time and quality of survival . The median survival time was 4.7 months for radiotherapy , 4.7 months for cyclophosphamide and 1.7 months for placebo . The median total sum of vitagram points was 28.1 for radiotherapy , 20.7 for cyclophosphamide and 6.8 for placebo . When calculated per month , the median sum of vitagram points was 5.9 for radiotherapy , 5.7 for cyclophosphamide and 4.8 for placebo . Statistically the results give no reason to believe that placebo is better than radiotherapy , but it can not be excluded that radiotherapy patients could have a much longer survival . As for cyclophosphamide versus radiotherapy , the differences are to uncertain for any conclusion to be drawn . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Intervention_Physical, Participant_Condition, Outcome_Mortality, Intervention_Control, Participant_Sample-size, Outcome_Other	[ "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "O", "O", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Bronchial carcinoma . II . Quantitative measurements of the quality of survival . A prospective randomized study of the result of therapy in inoperable patients with advanced disease . Forty-eight bronchial carcinoma patients in clinicoanatomical stage 4 of the disease ( advanced disease ) were randomly assigned to groups for radiotherapy , chemotherapy ( cyclophosphamide ) and placebo treatment , respectively . The results were assessed by the survival time and quality of survival . The median survival time was 4.7 months for radiotherapy , 4.7 months for cyclophosphamide and 1.7 months for placebo . The median total sum of vitagram points was 28.1 for radiotherapy , 20.7 for cyclophosphamide and 6.8 for placebo . When calculated per month , the median sum of vitagram points was 5.9 for radiotherapy , 5.7 for cyclophosphamide and 4.8 for placebo . Statistically the results give no reason to believe that placebo is better than radiotherapy , but it can not be excluded that radiotherapy patients could have a much longer survival . As for cyclophosphamide versus radiotherapy , the differences are to uncertain for any conclusion to be drawn .	[ "Bronchial", "carcinoma", ".", "II", ".", "Quantitative", "measurements", "of", "the", "quality", "of", "survival", ".", "A", "prospective", "randomized", "study", "of", "the", "result", "of", "therapy", "in", "inoperable", "patients", "with", "advanced", "disease", ".", "Forty", "-", "eight", "bronchial", "carcinoma", "patients", "in", "clinicoanatomical", "stage", "4", "of", "the", "disease", "(", "advanced", "disease", ")", "were", "randomly", "assigned", "to", "groups", "for", "radiotherapy", ",", "chemotherapy", "(", "cyclophosphamide", ")", "and", "placebo", "treatment", ",", "respectively", ".", "The", "results", "were", "assessed", "by", "the", "survival", "time", "and", "quality", "of", "survival", ".", "The", "median", "survival", "time", "was", "4.7", "months", "for", "radiotherapy", ",", "4.7", "months", "for", "cyclophosphamide", "and", "1.7", "months", "for", "placebo", ".", "The", "median", "total", "sum", "of", "vitagram", "points", "was", "28.1", "for", "radiotherapy", ",", "20.7", "for", "cyclophosphamide", "and", "6.8", "for", "placebo", ".", "When", "calculated", "per", "month", ",", "the", "median", "sum", "of", "vitagram", "points", "was", "5.9", "for", "radiotherapy", ",", "5.7", "for", "cyclophosphamide", "and", "4.8", "for", "placebo", ".", "Statistically", "the", "results", "give", "no", "reason", "to", "believe", "that", "placebo", "is", "better", "than", "radiotherapy", ",", "but", "it", "can", "not", "be", "excluded", "that", "radiotherapy", "patients", "could", "have", "a", "much", "longer", "survival", ".", "As", "for", "cyclophosphamide", "versus", "radiotherapy", ",", "the", "differences", "are", "to", "uncertain", "for", "any", "conclusion", "to", "be", "drawn", "." ]	[ "Outcome_Other", "Intervention_Pharmacological", "Outcome_Mortality", "Participant_Condition", "Intervention_Physical", "Participant_Sample-size", "Intervention_Control" ]
Bronchial carcinoma is a Participant_Condition, quality of survival is a Outcome_Mortality, Forty - eight is a Participant_Sample-size, bronchial carcinoma is a Participant_Condition, radiotherapy is a Intervention_Physical, chemotherapy ( cyclophosphamide ) is a Intervention_Pharmacological, placebo is a Intervention_Control, survival time is a Outcome_Mortality, median survival time is a Outcome_Mortality, median total sum of vitagram points is a Outcome_Other, median sum of vitagram points is a Outcome_Other	74012_task1	Sentence: Bronchial carcinoma . II . Quantitative measurements of the quality of survival . A prospective randomized study of the result of therapy in inoperable patients with advanced disease . Forty-eight bronchial carcinoma patients in clinicoanatomical stage 4 of the disease ( advanced disease ) were randomly assigned to groups for radiotherapy , chemotherapy ( cyclophosphamide ) and placebo treatment , respectively . The results were assessed by the survival time and quality of survival . The median survival time was 4.7 months for radiotherapy , 4.7 months for cyclophosphamide and 1.7 months for placebo . The median total sum of vitagram points was 28.1 for radiotherapy , 20.7 for cyclophosphamide and 6.8 for placebo . When calculated per month , the median sum of vitagram points was 5.9 for radiotherapy , 5.7 for cyclophosphamide and 4.8 for placebo . Statistically the results give no reason to believe that placebo is better than radiotherapy , but it can not be excluded that radiotherapy patients could have a much longer survival . As for cyclophosphamide versus radiotherapy , the differences are to uncertain for any conclusion to be drawn . Instructions: please typing these entity words according to sentence: Bronchial carcinoma, quality of survival, Forty - eight, bronchial carcinoma, radiotherapy, chemotherapy ( cyclophosphamide ), placebo, survival time, median survival time, median total sum of vitagram points, median sum of vitagram points Options: Intervention_Pharmacological, Intervention_Physical, Participant_Condition, Outcome_Mortality, Intervention_Control, Participant_Sample-size, Outcome_Other	[ "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "O", "O", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Bronchial carcinoma . II . Quantitative measurements of the quality of survival . A prospective randomized study of the result of therapy in inoperable patients with advanced disease . Forty-eight bronchial carcinoma patients in clinicoanatomical stage 4 of the disease ( advanced disease ) were randomly assigned to groups for radiotherapy , chemotherapy ( cyclophosphamide ) and placebo treatment , respectively . The results were assessed by the survival time and quality of survival . The median survival time was 4.7 months for radiotherapy , 4.7 months for cyclophosphamide and 1.7 months for placebo . The median total sum of vitagram points was 28.1 for radiotherapy , 20.7 for cyclophosphamide and 6.8 for placebo . When calculated per month , the median sum of vitagram points was 5.9 for radiotherapy , 5.7 for cyclophosphamide and 4.8 for placebo . Statistically the results give no reason to believe that placebo is better than radiotherapy , but it can not be excluded that radiotherapy patients could have a much longer survival . As for cyclophosphamide versus radiotherapy , the differences are to uncertain for any conclusion to be drawn .	[ "Bronchial", "carcinoma", ".", "II", ".", "Quantitative", "measurements", "of", "the", "quality", "of", "survival", ".", "A", "prospective", "randomized", "study", "of", "the", "result", "of", "therapy", "in", "inoperable", "patients", "with", "advanced", "disease", ".", "Forty", "-", "eight", "bronchial", "carcinoma", "patients", "in", "clinicoanatomical", "stage", "4", "of", "the", "disease", "(", "advanced", "disease", ")", "were", "randomly", "assigned", "to", "groups", "for", "radiotherapy", ",", "chemotherapy", "(", "cyclophosphamide", ")", "and", "placebo", "treatment", ",", "respectively", ".", "The", "results", "were", "assessed", "by", "the", "survival", "time", "and", "quality", "of", "survival", ".", "The", "median", "survival", "time", "was", "4.7", "months", "for", "radiotherapy", ",", "4.7", "months", "for", "cyclophosphamide", "and", "1.7", "months", "for", "placebo", ".", "The", "median", "total", "sum", "of", "vitagram", "points", "was", "28.1", "for", "radiotherapy", ",", "20.7", "for", "cyclophosphamide", "and", "6.8", "for", "placebo", ".", "When", "calculated", "per", "month", ",", "the", "median", "sum", "of", "vitagram", "points", "was", "5.9", "for", "radiotherapy", ",", "5.7", "for", "cyclophosphamide", "and", "4.8", "for", "placebo", ".", "Statistically", "the", "results", "give", "no", "reason", "to", "believe", "that", "placebo", "is", "better", "than", "radiotherapy", ",", "but", "it", "can", "not", "be", "excluded", "that", "radiotherapy", "patients", "could", "have", "a", "much", "longer", "survival", ".", "As", "for", "cyclophosphamide", "versus", "radiotherapy", ",", "the", "differences", "are", "to", "uncertain", "for", "any", "conclusion", "to", "be", "drawn", "." ]	[ "Outcome_Other", "Intervention_Pharmacological", "Outcome_Mortality", "Participant_Condition", "Intervention_Physical", "Participant_Sample-size", "Intervention_Control" ]
Bronchial carcinoma, quality of survival, Forty - eight, bronchial carcinoma, radiotherapy, chemotherapy ( cyclophosphamide ), placebo, survival time, median survival time, median total sum of vitagram points, median sum of vitagram points	74012_task2	Sentence: Bronchial carcinoma . II . Quantitative measurements of the quality of survival . A prospective randomized study of the result of therapy in inoperable patients with advanced disease . Forty-eight bronchial carcinoma patients in clinicoanatomical stage 4 of the disease ( advanced disease ) were randomly assigned to groups for radiotherapy , chemotherapy ( cyclophosphamide ) and placebo treatment , respectively . The results were assessed by the survival time and quality of survival . The median survival time was 4.7 months for radiotherapy , 4.7 months for cyclophosphamide and 1.7 months for placebo . The median total sum of vitagram points was 28.1 for radiotherapy , 20.7 for cyclophosphamide and 6.8 for placebo . When calculated per month , the median sum of vitagram points was 5.9 for radiotherapy , 5.7 for cyclophosphamide and 4.8 for placebo . Statistically the results give no reason to believe that placebo is better than radiotherapy , but it can not be excluded that radiotherapy patients could have a much longer survival . As for cyclophosphamide versus radiotherapy , the differences are to uncertain for any conclusion to be drawn . Instructions: please extract entity words from the input sentence	[ "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "O", "O", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Bronchial carcinoma . II . Quantitative measurements of the quality of survival . A prospective randomized study of the result of therapy in inoperable patients with advanced disease . Forty-eight bronchial carcinoma patients in clinicoanatomical stage 4 of the disease ( advanced disease ) were randomly assigned to groups for radiotherapy , chemotherapy ( cyclophosphamide ) and placebo treatment , respectively . The results were assessed by the survival time and quality of survival . The median survival time was 4.7 months for radiotherapy , 4.7 months for cyclophosphamide and 1.7 months for placebo . The median total sum of vitagram points was 28.1 for radiotherapy , 20.7 for cyclophosphamide and 6.8 for placebo . When calculated per month , the median sum of vitagram points was 5.9 for radiotherapy , 5.7 for cyclophosphamide and 4.8 for placebo . Statistically the results give no reason to believe that placebo is better than radiotherapy , but it can not be excluded that radiotherapy patients could have a much longer survival . As for cyclophosphamide versus radiotherapy , the differences are to uncertain for any conclusion to be drawn .	[ "Bronchial", "carcinoma", ".", "II", ".", "Quantitative", "measurements", "of", "the", "quality", "of", "survival", ".", "A", "prospective", "randomized", "study", "of", "the", "result", "of", "therapy", "in", "inoperable", "patients", "with", "advanced", "disease", ".", "Forty", "-", "eight", "bronchial", "carcinoma", "patients", "in", "clinicoanatomical", "stage", "4", "of", "the", "disease", "(", "advanced", "disease", ")", "were", "randomly", "assigned", "to", "groups", "for", "radiotherapy", ",", "chemotherapy", "(", "cyclophosphamide", ")", "and", "placebo", "treatment", ",", "respectively", ".", "The", "results", "were", "assessed", "by", "the", "survival", "time", "and", "quality", "of", "survival", ".", "The", "median", "survival", "time", "was", "4.7", "months", "for", "radiotherapy", ",", "4.7", "months", "for", "cyclophosphamide", "and", "1.7", "months", "for", "placebo", ".", "The", "median", "total", "sum", "of", "vitagram", "points", "was", "28.1", "for", "radiotherapy", ",", "20.7", "for", "cyclophosphamide", "and", "6.8", "for", "placebo", ".", "When", "calculated", "per", "month", ",", "the", "median", "sum", "of", "vitagram", "points", "was", "5.9", "for", "radiotherapy", ",", "5.7", "for", "cyclophosphamide", "and", "4.8", "for", "placebo", ".", "Statistically", "the", "results", "give", "no", "reason", "to", "believe", "that", "placebo", "is", "better", "than", "radiotherapy", ",", "but", "it", "can", "not", "be", "excluded", "that", "radiotherapy", "patients", "could", "have", "a", "much", "longer", "survival", ".", "As", "for", "cyclophosphamide", "versus", "radiotherapy", ",", "the", "differences", "are", "to", "uncertain", "for", "any", "conclusion", "to", "be", "drawn", "." ]	[ "Outcome_Other", "Intervention_Pharmacological", "Outcome_Mortality", "Participant_Condition", "Intervention_Physical", "Participant_Sample-size", "Intervention_Control" ]
functional T - cell receptor signaling pathway is an other_name, p95vav activity is an other_name	583_task0	Sentence: A functional T-cell receptor signaling pathway is required for p95vav activity. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: other_name	[ "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "O", "O", "O", "B-other_name", "I-other_name", "O" ]	A functional T-cell receptor signaling pathway is required for p95vav activity.	[ "A", "functional", "T", "-", "cell", "receptor", "signaling", "pathway", "is", "required", "for", "p95vav", "activity", "." ]	[ "protein_domain_or_region", "(AND other_name other_name)", "other_name", "(AND cell_type cell_type)", "protein_family_or_group", "other_organic_compound", "atom", "protein_molecule", "", "protein_substructure", "cell_line", "amino_acid_monomer", "cell_type" ]
functional T - cell receptor signaling pathway is an other_name, p95vav activity is an other_name	583_task1	Sentence: A functional T-cell receptor signaling pathway is required for p95vav activity. Instructions: please typing these entity words according to sentence: functional T - cell receptor signaling pathway, p95vav activity Options: other_name	[ "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "O", "O", "O", "B-other_name", "I-other_name", "O" ]	A functional T-cell receptor signaling pathway is required for p95vav activity.	[ "A", "functional", "T", "-", "cell", "receptor", "signaling", "pathway", "is", "required", "for", "p95vav", "activity", "." ]	[ "protein_domain_or_region", "(AND other_name other_name)", "other_name", "(AND cell_type cell_type)", "protein_family_or_group", "other_organic_compound", "atom", "protein_molecule", "", "protein_substructure", "cell_line", "amino_acid_monomer", "cell_type" ]

thrombocytopenic subjects with hepatitis C virus infection is a Participant_Condition, n = 1463 is a Participant_Sample-size, age ≥ 18 years is a Participant_Age, HCV infection is a Participant_Condition, include : having a HCV genotype 2 or 3 , being Central / South Asian , being White ( Caucasian or European heritage ) , increased weight , and increased spleen length is a Outcome_Physical, include : female gender , increased age , having a higher ALP plasma concentration , increased creatinine clearance , increased baseline lymphocytes count , and increased baseline platelet count is a Outcome_Physical

72138_task1

Sentence: Eltrombopag dose predictors in thrombocytopenic subjects with hepatitis C virus infection . This study aims to identify patient characteristics that predict effective eltrombopag dosage for the treatment of Hepatitis C virus ( HCV ) -related thrombocytopenia . Demographic , clinical and genetic data collected from thrombocytopenic patients ( n = 1463 , age ≥ 18 years ) with chronic HCV infection who were able to achieve a target platelet count of > 90 × 10 ( 9 ) /L following eltrombopag treatment . Patients were categorized into four groups ( 25 , 50 , 75 , and 100 mg ) based on the eltrombopag dose needed to achieve the target platelet count . Eltrombopag dose predictors were identified using a two stage approach . First , bivariate analysis , using anova for continuous variables and Chi-square test for categorical variables , was performed to identify possible predictors of eltrombopag dose ( P < 0.05 ) . Second , ordinal logistic regression with stepwise addition followed by backward deletion was then performed using predictors identified in bivariate analysis step to produce final model containing independent predictors at P < 0.05 . Ordinal logistic model identified several predictors of eltrombopag dose . Predictors of higher eltrombopag dose include : having a HCV genotype 2 or 3 , being Central/South Asian , being White ( Caucasian or European heritage ) , increased weight , and increased spleen length . Predictors of lower eltrombopag dose include : female gender , increased age , having a higher ALP plasma concentration , increased creatinine clearance , increased baseline lymphocytes count , and increased baseline platelet count . In conclusion , this study identified patient characteristics that predict effective eltrombopag dose for the treatment of HCV-related thrombocytopenia . Early selection of the optimal eltrombopag dose expedites the initiation of antiviral therapy . This is expected to improve the antiviral therapy outcome before the patient progress into liver decompensation . Instructions: please typing these entity words according to sentence: thrombocytopenic subjects with hepatitis C virus infection, n = 1463, age ≥ 18 years, HCV infection, include : having a HCV genotype 2 or 3 , being Central / South Asian , being White ( Caucasian or European heritage ) , increased weight , and increased spleen length, include : female gender , increased age , having a higher ALP plasma concentration , increased creatinine clearance , increased baseline lymphocytes count , and increased baseline platelet count Options: Outcome_Physical, Participant_Age, Participant_Condition, Participant_Sample-size

[ "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Eltrombopag dose predictors in thrombocytopenic subjects with hepatitis C virus infection . This study aims to identify patient characteristics that predict effective eltrombopag dosage for the treatment of Hepatitis C virus ( HCV ) -related thrombocytopenia . Demographic , clinical and genetic data collected from thrombocytopenic patients ( n = 1463 , age ≥ 18 years ) with chronic HCV infection who were able to achieve a target platelet count of > 90 × 10 ( 9 ) /L following eltrombopag treatment . Patients were categorized into four groups ( 25 , 50 , 75 , and 100 mg ) based on the eltrombopag dose needed to achieve the target platelet count . Eltrombopag dose predictors were identified using a two stage approach . First , bivariate analysis , using anova for continuous variables and Chi-square test for categorical variables , was performed to identify possible predictors of eltrombopag dose ( P < 0.05 ) . Second , ordinal logistic regression with stepwise addition followed by backward deletion was then performed using predictors identified in bivariate analysis step to produce final model containing independent predictors at P < 0.05 . Ordinal logistic model identified several predictors of eltrombopag dose . Predictors of higher eltrombopag dose include : having a HCV genotype 2 or 3 , being Central/South Asian , being White ( Caucasian or European heritage ) , increased weight , and increased spleen length . Predictors of lower eltrombopag dose include : female gender , increased age , having a higher ALP plasma concentration , increased creatinine clearance , increased baseline lymphocytes count , and increased baseline platelet count . In conclusion , this study identified patient characteristics that predict effective eltrombopag dose for the treatment of HCV-related thrombocytopenia . Early selection of the optimal eltrombopag dose expedites the initiation of antiviral therapy . This is expected to improve the antiviral therapy outcome before the patient progress into liver decompensation .

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[ "Outcome_Physical", "Participant_Condition", "Participant_Age", "Participant_Sample-size" ]

thrombocytopenic subjects with hepatitis C virus infection, n = 1463, age ≥ 18 years, HCV infection, include : having a HCV genotype 2 or 3 , being Central / South Asian , being White ( Caucasian or European heritage ) , increased weight , and increased spleen length, include : female gender , increased age , having a higher ALP plasma concentration , increased creatinine clearance , increased baseline lymphocytes count , and increased baseline platelet count

72138_task2

Sentence: Eltrombopag dose predictors in thrombocytopenic subjects with hepatitis C virus infection . This study aims to identify patient characteristics that predict effective eltrombopag dosage for the treatment of Hepatitis C virus ( HCV ) -related thrombocytopenia . Demographic , clinical and genetic data collected from thrombocytopenic patients ( n = 1463 , age ≥ 18 years ) with chronic HCV infection who were able to achieve a target platelet count of > 90 × 10 ( 9 ) /L following eltrombopag treatment . Patients were categorized into four groups ( 25 , 50 , 75 , and 100 mg ) based on the eltrombopag dose needed to achieve the target platelet count . Eltrombopag dose predictors were identified using a two stage approach . First , bivariate analysis , using anova for continuous variables and Chi-square test for categorical variables , was performed to identify possible predictors of eltrombopag dose ( P < 0.05 ) . Second , ordinal logistic regression with stepwise addition followed by backward deletion was then performed using predictors identified in bivariate analysis step to produce final model containing independent predictors at P < 0.05 . Ordinal logistic model identified several predictors of eltrombopag dose . Predictors of higher eltrombopag dose include : having a HCV genotype 2 or 3 , being Central/South Asian , being White ( Caucasian or European heritage ) , increased weight , and increased spleen length . Predictors of lower eltrombopag dose include : female gender , increased age , having a higher ALP plasma concentration , increased creatinine clearance , increased baseline lymphocytes count , and increased baseline platelet count . In conclusion , this study identified patient characteristics that predict effective eltrombopag dose for the treatment of HCV-related thrombocytopenia . Early selection of the optimal eltrombopag dose expedites the initiation of antiviral therapy . This is expected to improve the antiviral therapy outcome before the patient progress into liver decompensation . Instructions: please extract entity words from the input sentence

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Eltrombopag dose predictors in thrombocytopenic subjects with hepatitis C virus infection . This study aims to identify patient characteristics that predict effective eltrombopag dosage for the treatment of Hepatitis C virus ( HCV ) -related thrombocytopenia . Demographic , clinical and genetic data collected from thrombocytopenic patients ( n = 1463 , age ≥ 18 years ) with chronic HCV infection who were able to achieve a target platelet count of > 90 × 10 ( 9 ) /L following eltrombopag treatment . Patients were categorized into four groups ( 25 , 50 , 75 , and 100 mg ) based on the eltrombopag dose needed to achieve the target platelet count . Eltrombopag dose predictors were identified using a two stage approach . First , bivariate analysis , using anova for continuous variables and Chi-square test for categorical variables , was performed to identify possible predictors of eltrombopag dose ( P < 0.05 ) . Second , ordinal logistic regression with stepwise addition followed by backward deletion was then performed using predictors identified in bivariate analysis step to produce final model containing independent predictors at P < 0.05 . Ordinal logistic model identified several predictors of eltrombopag dose . Predictors of higher eltrombopag dose include : having a HCV genotype 2 or 3 , being Central/South Asian , being White ( Caucasian or European heritage ) , increased weight , and increased spleen length . Predictors of lower eltrombopag dose include : female gender , increased age , having a higher ALP plasma concentration , increased creatinine clearance , increased baseline lymphocytes count , and increased baseline platelet count . In conclusion , this study identified patient characteristics that predict effective eltrombopag dose for the treatment of HCV-related thrombocytopenia . Early selection of the optimal eltrombopag dose expedites the initiation of antiviral therapy . This is expected to improve the antiviral therapy outcome before the patient progress into liver decompensation .

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[ "Outcome_Physical", "Participant_Condition", "Participant_Age", "Participant_Sample-size" ]

younger than 18 years is a Value, old is a Person, HBsAg negative is a Condition, at baseline is a Temporal, pregnant or lactating is a Scope, women is a Person

NCT01768195_exc_task0

Sentence: younger than 18 years old HBsAg negative at baseline pregnant or lactating women Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Temporal, Condition, Value, Person, Scope

[ "B-Value", "I-Value", "I-Value", "I-Value", "B-Person", "O", "B-Condition", "I-Condition", "B-Temporal", "I-Temporal", "O", "B-Scope", "I-Scope", "I-Scope", "B-Person", "O" ]

younger than 18 years old HBsAg negative at baseline pregnant or lactating women

[ "younger", "than", "18", "years", "old", "\n", "HBsAg", "negative", "at", "baseline", "\n", "pregnant", "or", "lactating", "women", "\n" ]

[ "Value", "Scope", "Condition", "Temporal", "Person" ]

younger than 18 years is a Value, old is a Person, HBsAg negative is a Condition, at baseline is a Temporal, pregnant or lactating is a Scope, women is a Person

NCT01768195_exc_task1

Sentence: younger than 18 years old HBsAg negative at baseline pregnant or lactating women Instructions: please typing these entity words according to sentence: younger than 18 years, old, HBsAg negative, at baseline, pregnant or lactating, women Options: Temporal, Condition, Value, Person, Scope

[ "B-Value", "I-Value", "I-Value", "I-Value", "B-Person", "O", "B-Condition", "I-Condition", "B-Temporal", "I-Temporal", "O", "B-Scope", "I-Scope", "I-Scope", "B-Person", "O" ]

younger than 18 years old HBsAg negative at baseline pregnant or lactating women

[ "younger", "than", "18", "years", "old", "\n", "HBsAg", "negative", "at", "baseline", "\n", "pregnant", "or", "lactating", "women", "\n" ]

[ "Value", "Scope", "Condition", "Temporal", "Person" ]

younger than 18 years, old, HBsAg negative, at baseline, pregnant or lactating, women

NCT01768195_exc_task2

Sentence: younger than 18 years old HBsAg negative at baseline pregnant or lactating women Instructions: please extract entity words from the input sentence

[ "B-Value", "I-Value", "I-Value", "I-Value", "B-Person", "O", "B-Condition", "I-Condition", "B-Temporal", "I-Temporal", "O", "B-Scope", "I-Scope", "I-Scope", "B-Person", "O" ]

younger than 18 years old HBsAg negative at baseline pregnant or lactating women

[ "younger", "than", "18", "years", "old", "\n", "HBsAg", "negative", "at", "baseline", "\n", "pregnant", "or", "lactating", "women", "\n" ]

[ "Value", "Scope", "Condition", "Temporal", "Person" ]

Behandlung is an umlsterm, Personen is an umlsterm, Behandlung is an umlsterm, selbst is an umlsterm, Wissen is an umlsterm

DerUnfallchirurg.81010402.ger.abstr_task0

Sentence: Bei der Behandlung von Personen mit Schussverletzungen sollten kriminalistische Gesichtspunkte nicht ganz ausser acht bleiben , denn fuer die Ermittlungsbehoerden ergibt sich die Notwendigkeit zu klaeren , wer geschossen hat , aus welcher Richtung und Entfernung geschossen wurde und wie viele Schuesse es waren . Hierzu koennen Feststellungen des behandelnden Chirurgen entscheidend weiterhelfen . Sie setzen vor allem eine sorgfaeltige Inspektion voraus . Fuer die Behandlung selbst ist das Wissen darum wichtig , dass Schusskanaele nicht immer geradlinig durch den Koerper verlaufen . Liegt ein Winkelschuss , ein gebrochener Schusskanal oder ein Kontur- oder Ringelschuss vor , koennen Organe verletzt werden , die nicht auf der direkten Verbindungslinie zwischen dem Einschuss und dem Ausschuss bzw. - bei einem Steckschuss - dem Einschuss und der Endlage des Projektils liegen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Bei der Behandlung von Personen mit Schussverletzungen sollten kriminalistische Gesichtspunkte nicht ganz ausser acht bleiben , denn fuer die Ermittlungsbehoerden ergibt sich die Notwendigkeit zu klaeren , wer geschossen hat , aus welcher Richtung und Entfernung geschossen wurde und wie viele Schuesse es waren . Hierzu koennen Feststellungen des behandelnden Chirurgen entscheidend weiterhelfen . Sie setzen vor allem eine sorgfaeltige Inspektion voraus . Fuer die Behandlung selbst ist das Wissen darum wichtig , dass Schusskanaele nicht immer geradlinig durch den Koerper verlaufen . Liegt ein Winkelschuss , ein gebrochener Schusskanal oder ein Kontur- oder Ringelschuss vor , koennen Organe verletzt werden , die nicht auf der direkten Verbindungslinie zwischen dem Einschuss und dem Ausschuss bzw. - bei einem Steckschuss - dem Einschuss und der Endlage des Projektils liegen .

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[ "umlsterm" ]

Behandlung is an umlsterm, Personen is an umlsterm, Behandlung is an umlsterm, selbst is an umlsterm, Wissen is an umlsterm

DerUnfallchirurg.81010402.ger.abstr_task1

Sentence: Bei der Behandlung von Personen mit Schussverletzungen sollten kriminalistische Gesichtspunkte nicht ganz ausser acht bleiben , denn fuer die Ermittlungsbehoerden ergibt sich die Notwendigkeit zu klaeren , wer geschossen hat , aus welcher Richtung und Entfernung geschossen wurde und wie viele Schuesse es waren . Hierzu koennen Feststellungen des behandelnden Chirurgen entscheidend weiterhelfen . Sie setzen vor allem eine sorgfaeltige Inspektion voraus . Fuer die Behandlung selbst ist das Wissen darum wichtig , dass Schusskanaele nicht immer geradlinig durch den Koerper verlaufen . Liegt ein Winkelschuss , ein gebrochener Schusskanal oder ein Kontur- oder Ringelschuss vor , koennen Organe verletzt werden , die nicht auf der direkten Verbindungslinie zwischen dem Einschuss und dem Ausschuss bzw. - bei einem Steckschuss - dem Einschuss und der Endlage des Projektils liegen . Instructions: please typing these entity words according to sentence: Behandlung, Personen, Behandlung, selbst, Wissen Options: umlsterm

[ "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Bei der Behandlung von Personen mit Schussverletzungen sollten kriminalistische Gesichtspunkte nicht ganz ausser acht bleiben , denn fuer die Ermittlungsbehoerden ergibt sich die Notwendigkeit zu klaeren , wer geschossen hat , aus welcher Richtung und Entfernung geschossen wurde und wie viele Schuesse es waren . Hierzu koennen Feststellungen des behandelnden Chirurgen entscheidend weiterhelfen . Sie setzen vor allem eine sorgfaeltige Inspektion voraus . Fuer die Behandlung selbst ist das Wissen darum wichtig , dass Schusskanaele nicht immer geradlinig durch den Koerper verlaufen . Liegt ein Winkelschuss , ein gebrochener Schusskanal oder ein Kontur- oder Ringelschuss vor , koennen Organe verletzt werden , die nicht auf der direkten Verbindungslinie zwischen dem Einschuss und dem Ausschuss bzw. - bei einem Steckschuss - dem Einschuss und der Endlage des Projektils liegen .

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[ "umlsterm" ]

Behandlung, Personen, Behandlung, selbst, Wissen

DerUnfallchirurg.81010402.ger.abstr_task2

Sentence: Bei der Behandlung von Personen mit Schussverletzungen sollten kriminalistische Gesichtspunkte nicht ganz ausser acht bleiben , denn fuer die Ermittlungsbehoerden ergibt sich die Notwendigkeit zu klaeren , wer geschossen hat , aus welcher Richtung und Entfernung geschossen wurde und wie viele Schuesse es waren . Hierzu koennen Feststellungen des behandelnden Chirurgen entscheidend weiterhelfen . Sie setzen vor allem eine sorgfaeltige Inspektion voraus . Fuer die Behandlung selbst ist das Wissen darum wichtig , dass Schusskanaele nicht immer geradlinig durch den Koerper verlaufen . Liegt ein Winkelschuss , ein gebrochener Schusskanal oder ein Kontur- oder Ringelschuss vor , koennen Organe verletzt werden , die nicht auf der direkten Verbindungslinie zwischen dem Einschuss und dem Ausschuss bzw. - bei einem Steckschuss - dem Einschuss und der Endlage des Projektils liegen . Instructions: please extract entity words from the input sentence

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Bei der Behandlung von Personen mit Schussverletzungen sollten kriminalistische Gesichtspunkte nicht ganz ausser acht bleiben , denn fuer die Ermittlungsbehoerden ergibt sich die Notwendigkeit zu klaeren , wer geschossen hat , aus welcher Richtung und Entfernung geschossen wurde und wie viele Schuesse es waren . Hierzu koennen Feststellungen des behandelnden Chirurgen entscheidend weiterhelfen . Sie setzen vor allem eine sorgfaeltige Inspektion voraus . Fuer die Behandlung selbst ist das Wissen darum wichtig , dass Schusskanaele nicht immer geradlinig durch den Koerper verlaufen . Liegt ein Winkelschuss , ein gebrochener Schusskanal oder ein Kontur- oder Ringelschuss vor , koennen Organe verletzt werden , die nicht auf der direkten Verbindungslinie zwischen dem Einschuss und dem Ausschuss bzw. - bei einem Steckschuss - dem Einschuss und der Endlage des Projektils liegen .

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[ "umlsterm" ]

Leistenbruchversorgung is an umlsterm, Leichen is an umlsterm, Universitaet is an umlsterm, topographische Anatomie is an umlsterm, Metaanalyse is an umlsterm, Komplikationen is an umlsterm, Technik is an umlsterm, Leistenbruchversorgung is an umlsterm, topographischen Anatomie is an umlsterm, Leistenbruchversorgung is an umlsterm

DerChirurg.60670807.ger.abstr_task0

Sentence: Zusammenfassung . In der Diskussion ueber Sinn und Unsinn einer laparoskopischen Leistenbruchversorgung wird immer wieder die Gefaehrdung wichtiger anatomischer Strukturen durch den extraperitonealen oder transabdominellen praeperitonealen Zugang angefuehrt . Anhand von eigenen anatomischen Praeparationen an acht Leichen des Anatomischen Institutes der Universitaet Ulm wird auf die topographische Anatomie der Leistenregion und seiner wichtigen Strukturen hingewiesen . Unsere Erkenntnisse werden zu einer Metaanalyse der bisher publizierten Komplikationen dieser neuen Technik der Leistenbruchversorgung in Bezug gesetzt . Unter genuegender Beruecksichtigung der topographischen Anatomie kann die Komplikationsrate der laparoskopischen Leistenbruchversorgung weiter deutlich gesenkt werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]

Zusammenfassung . In der Diskussion ueber Sinn und Unsinn einer laparoskopischen Leistenbruchversorgung wird immer wieder die Gefaehrdung wichtiger anatomischer Strukturen durch den extraperitonealen oder transabdominellen praeperitonealen Zugang angefuehrt . Anhand von eigenen anatomischen Praeparationen an acht Leichen des Anatomischen Institutes der Universitaet Ulm wird auf die topographische Anatomie der Leistenregion und seiner wichtigen Strukturen hingewiesen . Unsere Erkenntnisse werden zu einer Metaanalyse der bisher publizierten Komplikationen dieser neuen Technik der Leistenbruchversorgung in Bezug gesetzt . Unter genuegender Beruecksichtigung der topographischen Anatomie kann die Komplikationsrate der laparoskopischen Leistenbruchversorgung weiter deutlich gesenkt werden .

[ "Zusammenfassung", ".", "In", "der", "Diskussion", "ueber", "Sinn", "und", "Unsinn", "einer", "laparoskopischen", "Leistenbruchversorgung", "wird", "immer", "wieder", "die", "Gefaehrdung", "wichtiger", "anatomischer", "Strukturen", "durch", "den", "extraperitonealen", "oder", "transabdominellen", "praeperitonealen", "Zugang", "angefuehrt", ".", "Anhand", "von", "eigenen", "anatomischen", "Praeparationen", "an", "acht", "Leichen", "des", "Anatomischen", "Institutes", "der", "Universitaet", "Ulm", "wird", "auf", "die", "topographische", "Anatomie", "der", "Leistenregion", "und", "seiner", "wichtigen", "Strukturen", "hingewiesen", ".", "Unsere", "Erkenntnisse", "werden", "zu", "einer", "Metaanalyse", "der", "bisher", "publizierten", "Komplikationen", "dieser", "neuen", "Technik", "der", "Leistenbruchversorgung", "in", "Bezug", "gesetzt", ".", "Unter", "genuegender", "Beruecksichtigung", "der", "topographischen", "Anatomie", "kann", "die", "Komplikationsrate", "der", "laparoskopischen", "Leistenbruchversorgung", "weiter", "deutlich", "gesenkt", "werden", "." ]

[ "umlsterm" ]

Leistenbruchversorgung is an umlsterm, Leichen is an umlsterm, Universitaet is an umlsterm, topographische Anatomie is an umlsterm, Metaanalyse is an umlsterm, Komplikationen is an umlsterm, Technik is an umlsterm, Leistenbruchversorgung is an umlsterm, topographischen Anatomie is an umlsterm, Leistenbruchversorgung is an umlsterm

DerChirurg.60670807.ger.abstr_task1

Sentence: Zusammenfassung . In der Diskussion ueber Sinn und Unsinn einer laparoskopischen Leistenbruchversorgung wird immer wieder die Gefaehrdung wichtiger anatomischer Strukturen durch den extraperitonealen oder transabdominellen praeperitonealen Zugang angefuehrt . Anhand von eigenen anatomischen Praeparationen an acht Leichen des Anatomischen Institutes der Universitaet Ulm wird auf die topographische Anatomie der Leistenregion und seiner wichtigen Strukturen hingewiesen . Unsere Erkenntnisse werden zu einer Metaanalyse der bisher publizierten Komplikationen dieser neuen Technik der Leistenbruchversorgung in Bezug gesetzt . Unter genuegender Beruecksichtigung der topographischen Anatomie kann die Komplikationsrate der laparoskopischen Leistenbruchversorgung weiter deutlich gesenkt werden . Instructions: please typing these entity words according to sentence: Leistenbruchversorgung, Leichen, Universitaet, topographische Anatomie, Metaanalyse, Komplikationen, Technik, Leistenbruchversorgung, topographischen Anatomie, Leistenbruchversorgung Options: umlsterm

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Zusammenfassung . In der Diskussion ueber Sinn und Unsinn einer laparoskopischen Leistenbruchversorgung wird immer wieder die Gefaehrdung wichtiger anatomischer Strukturen durch den extraperitonealen oder transabdominellen praeperitonealen Zugang angefuehrt . Anhand von eigenen anatomischen Praeparationen an acht Leichen des Anatomischen Institutes der Universitaet Ulm wird auf die topographische Anatomie der Leistenregion und seiner wichtigen Strukturen hingewiesen . Unsere Erkenntnisse werden zu einer Metaanalyse der bisher publizierten Komplikationen dieser neuen Technik der Leistenbruchversorgung in Bezug gesetzt . Unter genuegender Beruecksichtigung der topographischen Anatomie kann die Komplikationsrate der laparoskopischen Leistenbruchversorgung weiter deutlich gesenkt werden .

[ "Zusammenfassung", ".", "In", "der", "Diskussion", "ueber", "Sinn", "und", "Unsinn", "einer", "laparoskopischen", "Leistenbruchversorgung", "wird", "immer", "wieder", "die", "Gefaehrdung", "wichtiger", "anatomischer", "Strukturen", "durch", "den", "extraperitonealen", "oder", "transabdominellen", "praeperitonealen", "Zugang", "angefuehrt", ".", "Anhand", "von", "eigenen", "anatomischen", "Praeparationen", "an", "acht", "Leichen", "des", "Anatomischen", "Institutes", "der", "Universitaet", "Ulm", "wird", "auf", "die", "topographische", "Anatomie", "der", "Leistenregion", "und", "seiner", "wichtigen", "Strukturen", "hingewiesen", ".", "Unsere", "Erkenntnisse", "werden", "zu", "einer", "Metaanalyse", "der", "bisher", "publizierten", "Komplikationen", "dieser", "neuen", "Technik", "der", "Leistenbruchversorgung", "in", "Bezug", "gesetzt", ".", "Unter", "genuegender", "Beruecksichtigung", "der", "topographischen", "Anatomie", "kann", "die", "Komplikationsrate", "der", "laparoskopischen", "Leistenbruchversorgung", "weiter", "deutlich", "gesenkt", "werden", "." ]

[ "umlsterm" ]

Leistenbruchversorgung, Leichen, Universitaet, topographische Anatomie, Metaanalyse, Komplikationen, Technik, Leistenbruchversorgung, topographischen Anatomie, Leistenbruchversorgung

DerChirurg.60670807.ger.abstr_task2

Sentence: Zusammenfassung . In der Diskussion ueber Sinn und Unsinn einer laparoskopischen Leistenbruchversorgung wird immer wieder die Gefaehrdung wichtiger anatomischer Strukturen durch den extraperitonealen oder transabdominellen praeperitonealen Zugang angefuehrt . Anhand von eigenen anatomischen Praeparationen an acht Leichen des Anatomischen Institutes der Universitaet Ulm wird auf die topographische Anatomie der Leistenregion und seiner wichtigen Strukturen hingewiesen . Unsere Erkenntnisse werden zu einer Metaanalyse der bisher publizierten Komplikationen dieser neuen Technik der Leistenbruchversorgung in Bezug gesetzt . Unter genuegender Beruecksichtigung der topographischen Anatomie kann die Komplikationsrate der laparoskopischen Leistenbruchversorgung weiter deutlich gesenkt werden . Instructions: please extract entity words from the input sentence

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Zusammenfassung . In der Diskussion ueber Sinn und Unsinn einer laparoskopischen Leistenbruchversorgung wird immer wieder die Gefaehrdung wichtiger anatomischer Strukturen durch den extraperitonealen oder transabdominellen praeperitonealen Zugang angefuehrt . Anhand von eigenen anatomischen Praeparationen an acht Leichen des Anatomischen Institutes der Universitaet Ulm wird auf die topographische Anatomie der Leistenregion und seiner wichtigen Strukturen hingewiesen . Unsere Erkenntnisse werden zu einer Metaanalyse der bisher publizierten Komplikationen dieser neuen Technik der Leistenbruchversorgung in Bezug gesetzt . Unter genuegender Beruecksichtigung der topographischen Anatomie kann die Komplikationsrate der laparoskopischen Leistenbruchversorgung weiter deutlich gesenkt werden .

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[ "umlsterm" ]

Serum bactericidal activities is a Outcome_Physical, comparative pharmacokinetics is a Outcome_Other, meropenem is a Intervention_Pharmacological, imipenem is a Intervention_Pharmacological, serum bactericidal activities ( SBAs ) is a Outcome_Physical, Twelve healthy male volunteers is a Participant_Condition, imipenem plus 1 g of cilastatin is a Intervention_Pharmacological, 1 g of meropenem is a Intervention_Pharmacological, concentrations of the drugs in serum and urine is a Outcome_Physical, bioassay and high - pressure liquid chromatography . is a Outcome_Other, two - compartment model is a Intervention_Physical, noncompartmental technique is a Intervention_Physical, mean concentrations of imipenem and meropenem measured in serum is a Outcome_Physical, urinary recoveries is a Outcome_Physical, areas under the concentration - time curve is a Outcome_Physical, microdilution method of Reller and Stratton is a Outcome_Other, Mean reciprocal bactericidal titers is a Outcome_Physical, half - lives is a Outcome_Other, SBAs against clinically important pathogens is a Outcome_Physical

87737_task0

Sentence: Serum bactericidal activities and comparative pharmacokinetics of meropenem and imipenem-cilastatin . The pharmacokinetics and serum bactericidal activities ( SBAs ) of imipenem and meropenem were investigated in a randomized crossover study . Twelve healthy male volunteers received a constant 30-min infusion of either 1 g of imipenem plus 1 g of cilastatin or 1 g of meropenem . The concentrations of the drugs in serum and urine were determined by bioassay and high-pressure liquid chromatography . Pharmacokinetic parameters were based on an open two-compartment model and a noncompartmental technique . At the end of infusion , the mean concentrations of imipenem and meropenem measured in serum were 61.2 +/- 9.8 and 51.6 +/- 6.5 mg/liter , respectively ; urinary recoveries were 48.6 % +/- 8.2 % and 60.0 % +/- 6.5 % of the dose in 12 h , respectively ; and the areas under the concentration-time curve from time zero to infinity were 96.1 +/- 14.4 and 70.5 +/- 10.3 mg.h/liter , respectively ( P < or = 0.02 ) . Imipenem had a mean half-life of 66.7 +/- 10.4 min ; that of meropenem was 64.4 +/- 6.9 min . The volumes of distribution at steady state of imipenem and meropenem were 15.3 +/- 3.3 and 18.6 +/- 3.0 liters/70 kg , respectively , and the mean renal clearances per 1.73 m2 were 85.6 +/- 17.6 and 144.6 +/- 26.0 ml/min , respectively . Both antibiotics were well tolerated in this single-dose administration study . The SBAs were measured by the microdilution method of Reller and Stratton ( L. B. Reller and C. W. Stratton , J. Infect . Dis . 136:196-204 , 1977 ) against 40 clinically isolated strains . Mean reciprocal bactericidal titers were measured 1 and 6 h after administration . After 1 and 6 h the median SBAs for imipenem and meropenem , were 409 and 34.9 and 97.9 and 5.8 , respectively , against Staphylococcus aureus , 19.9 and 4.4 and 19.4 and 4.8 , respectively , against Pseudomonas aeruginosa , 34.3 and 2.2 and 232 and 15.5 , respectively , against Enterobacter cloacae , and 13.4 and 2.25 and 90.7 and 7.9 , respectively , against Proteus mirabilis . Both drugs had rather short biological elimination half-lives and a predominantly renal route of elimination . Both carbapenems revealed high SBAs against clinically important pathogens at 1 h ; meropenem had a higher SBA against E. cloacae and P. mirabilis , and the SBA of imipenem against S. aureus was greater than the SBA of meropenem . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Intervention_Physical, Participant_Condition, Outcome_Physical, Outcome_Other

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Serum bactericidal activities and comparative pharmacokinetics of meropenem and imipenem-cilastatin . The pharmacokinetics and serum bactericidal activities ( SBAs ) of imipenem and meropenem were investigated in a randomized crossover study . Twelve healthy male volunteers received a constant 30-min infusion of either 1 g of imipenem plus 1 g of cilastatin or 1 g of meropenem . The concentrations of the drugs in serum and urine were determined by bioassay and high-pressure liquid chromatography . Pharmacokinetic parameters were based on an open two-compartment model and a noncompartmental technique . At the end of infusion , the mean concentrations of imipenem and meropenem measured in serum were 61.2 +/- 9.8 and 51.6 +/- 6.5 mg/liter , respectively ; urinary recoveries were 48.6 % +/- 8.2 % and 60.0 % +/- 6.5 % of the dose in 12 h , respectively ; and the areas under the concentration-time curve from time zero to infinity were 96.1 +/- 14.4 and 70.5 +/- 10.3 mg.h/liter , respectively ( P < or = 0.02 ) . Imipenem had a mean half-life of 66.7 +/- 10.4 min ; that of meropenem was 64.4 +/- 6.9 min . The volumes of distribution at steady state of imipenem and meropenem were 15.3 +/- 3.3 and 18.6 +/- 3.0 liters/70 kg , respectively , and the mean renal clearances per 1.73 m2 were 85.6 +/- 17.6 and 144.6 +/- 26.0 ml/min , respectively . Both antibiotics were well tolerated in this single-dose administration study . The SBAs were measured by the microdilution method of Reller and Stratton ( L. B. Reller and C. W. Stratton , J. Infect . Dis . 136:196-204 , 1977 ) against 40 clinically isolated strains . Mean reciprocal bactericidal titers were measured 1 and 6 h after administration . After 1 and 6 h the median SBAs for imipenem and meropenem , were 409 and 34.9 and 97.9 and 5.8 , respectively , against Staphylococcus aureus , 19.9 and 4.4 and 19.4 and 4.8 , respectively , against Pseudomonas aeruginosa , 34.3 and 2.2 and 232 and 15.5 , respectively , against Enterobacter cloacae , and 13.4 and 2.25 and 90.7 and 7.9 , respectively , against Proteus mirabilis . Both drugs had rather short biological elimination half-lives and a predominantly renal route of elimination . Both carbapenems revealed high SBAs against clinically important pathogens at 1 h ; meropenem had a higher SBA against E. cloacae and P. mirabilis , and the SBA of imipenem against S. aureus was greater than the SBA of meropenem .

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[ "Outcome_Physical", "Outcome_Other", "Intervention_Physical", "Intervention_Pharmacological", "Participant_Condition" ]

Serum bactericidal activities is a Outcome_Physical, comparative pharmacokinetics is a Outcome_Other, meropenem is a Intervention_Pharmacological, imipenem is a Intervention_Pharmacological, serum bactericidal activities ( SBAs ) is a Outcome_Physical, Twelve healthy male volunteers is a Participant_Condition, imipenem plus 1 g of cilastatin is a Intervention_Pharmacological, 1 g of meropenem is a Intervention_Pharmacological, concentrations of the drugs in serum and urine is a Outcome_Physical, bioassay and high - pressure liquid chromatography . is a Outcome_Other, two - compartment model is a Intervention_Physical, noncompartmental technique is a Intervention_Physical, mean concentrations of imipenem and meropenem measured in serum is a Outcome_Physical, urinary recoveries is a Outcome_Physical, areas under the concentration - time curve is a Outcome_Physical, microdilution method of Reller and Stratton is a Outcome_Other, Mean reciprocal bactericidal titers is a Outcome_Physical, half - lives is a Outcome_Other, SBAs against clinically important pathogens is a Outcome_Physical

87737_task1

Sentence: Serum bactericidal activities and comparative pharmacokinetics of meropenem and imipenem-cilastatin . The pharmacokinetics and serum bactericidal activities ( SBAs ) of imipenem and meropenem were investigated in a randomized crossover study . Twelve healthy male volunteers received a constant 30-min infusion of either 1 g of imipenem plus 1 g of cilastatin or 1 g of meropenem . The concentrations of the drugs in serum and urine were determined by bioassay and high-pressure liquid chromatography . Pharmacokinetic parameters were based on an open two-compartment model and a noncompartmental technique . At the end of infusion , the mean concentrations of imipenem and meropenem measured in serum were 61.2 +/- 9.8 and 51.6 +/- 6.5 mg/liter , respectively ; urinary recoveries were 48.6 % +/- 8.2 % and 60.0 % +/- 6.5 % of the dose in 12 h , respectively ; and the areas under the concentration-time curve from time zero to infinity were 96.1 +/- 14.4 and 70.5 +/- 10.3 mg.h/liter , respectively ( P < or = 0.02 ) . Imipenem had a mean half-life of 66.7 +/- 10.4 min ; that of meropenem was 64.4 +/- 6.9 min . The volumes of distribution at steady state of imipenem and meropenem were 15.3 +/- 3.3 and 18.6 +/- 3.0 liters/70 kg , respectively , and the mean renal clearances per 1.73 m2 were 85.6 +/- 17.6 and 144.6 +/- 26.0 ml/min , respectively . Both antibiotics were well tolerated in this single-dose administration study . The SBAs were measured by the microdilution method of Reller and Stratton ( L. B. Reller and C. W. Stratton , J. Infect . Dis . 136:196-204 , 1977 ) against 40 clinically isolated strains . Mean reciprocal bactericidal titers were measured 1 and 6 h after administration . After 1 and 6 h the median SBAs for imipenem and meropenem , were 409 and 34.9 and 97.9 and 5.8 , respectively , against Staphylococcus aureus , 19.9 and 4.4 and 19.4 and 4.8 , respectively , against Pseudomonas aeruginosa , 34.3 and 2.2 and 232 and 15.5 , respectively , against Enterobacter cloacae , and 13.4 and 2.25 and 90.7 and 7.9 , respectively , against Proteus mirabilis . Both drugs had rather short biological elimination half-lives and a predominantly renal route of elimination . Both carbapenems revealed high SBAs against clinically important pathogens at 1 h ; meropenem had a higher SBA against E. cloacae and P. mirabilis , and the SBA of imipenem against S. aureus was greater than the SBA of meropenem . Instructions: please typing these entity words according to sentence: Serum bactericidal activities, comparative pharmacokinetics, meropenem, imipenem, serum bactericidal activities ( SBAs ), Twelve healthy male volunteers, imipenem plus 1 g of cilastatin, 1 g of meropenem, concentrations of the drugs in serum and urine, bioassay and high - pressure liquid chromatography ., two - compartment model, noncompartmental technique, mean concentrations of imipenem and meropenem measured in serum, urinary recoveries, areas under the concentration - time curve, microdilution method of Reller and Stratton, Mean reciprocal bactericidal titers, half - lives, SBAs against clinically important pathogens Options: Intervention_Pharmacological, Intervention_Physical, Participant_Condition, Outcome_Physical, Outcome_Other

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Serum bactericidal activities and comparative pharmacokinetics of meropenem and imipenem-cilastatin . The pharmacokinetics and serum bactericidal activities ( SBAs ) of imipenem and meropenem were investigated in a randomized crossover study . Twelve healthy male volunteers received a constant 30-min infusion of either 1 g of imipenem plus 1 g of cilastatin or 1 g of meropenem . The concentrations of the drugs in serum and urine were determined by bioassay and high-pressure liquid chromatography . Pharmacokinetic parameters were based on an open two-compartment model and a noncompartmental technique . At the end of infusion , the mean concentrations of imipenem and meropenem measured in serum were 61.2 +/- 9.8 and 51.6 +/- 6.5 mg/liter , respectively ; urinary recoveries were 48.6 % +/- 8.2 % and 60.0 % +/- 6.5 % of the dose in 12 h , respectively ; and the areas under the concentration-time curve from time zero to infinity were 96.1 +/- 14.4 and 70.5 +/- 10.3 mg.h/liter , respectively ( P < or = 0.02 ) . Imipenem had a mean half-life of 66.7 +/- 10.4 min ; that of meropenem was 64.4 +/- 6.9 min . The volumes of distribution at steady state of imipenem and meropenem were 15.3 +/- 3.3 and 18.6 +/- 3.0 liters/70 kg , respectively , and the mean renal clearances per 1.73 m2 were 85.6 +/- 17.6 and 144.6 +/- 26.0 ml/min , respectively . Both antibiotics were well tolerated in this single-dose administration study . The SBAs were measured by the microdilution method of Reller and Stratton ( L. B. Reller and C. W. Stratton , J. Infect . Dis . 136:196-204 , 1977 ) against 40 clinically isolated strains . Mean reciprocal bactericidal titers were measured 1 and 6 h after administration . After 1 and 6 h the median SBAs for imipenem and meropenem , were 409 and 34.9 and 97.9 and 5.8 , respectively , against Staphylococcus aureus , 19.9 and 4.4 and 19.4 and 4.8 , respectively , against Pseudomonas aeruginosa , 34.3 and 2.2 and 232 and 15.5 , respectively , against Enterobacter cloacae , and 13.4 and 2.25 and 90.7 and 7.9 , respectively , against Proteus mirabilis . Both drugs had rather short biological elimination half-lives and a predominantly renal route of elimination . Both carbapenems revealed high SBAs against clinically important pathogens at 1 h ; meropenem had a higher SBA against E. cloacae and P. mirabilis , and the SBA of imipenem against S. aureus was greater than the SBA of meropenem .

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[ "Outcome_Physical", "Outcome_Other", "Intervention_Physical", "Intervention_Pharmacological", "Participant_Condition" ]

Serum bactericidal activities, comparative pharmacokinetics, meropenem, imipenem, serum bactericidal activities ( SBAs ), Twelve healthy male volunteers, imipenem plus 1 g of cilastatin, 1 g of meropenem, concentrations of the drugs in serum and urine, bioassay and high - pressure liquid chromatography ., two - compartment model, noncompartmental technique, mean concentrations of imipenem and meropenem measured in serum, urinary recoveries, areas under the concentration - time curve, microdilution method of Reller and Stratton, Mean reciprocal bactericidal titers, half - lives, SBAs against clinically important pathogens

87737_task2

Sentence: Serum bactericidal activities and comparative pharmacokinetics of meropenem and imipenem-cilastatin . The pharmacokinetics and serum bactericidal activities ( SBAs ) of imipenem and meropenem were investigated in a randomized crossover study . Twelve healthy male volunteers received a constant 30-min infusion of either 1 g of imipenem plus 1 g of cilastatin or 1 g of meropenem . The concentrations of the drugs in serum and urine were determined by bioassay and high-pressure liquid chromatography . Pharmacokinetic parameters were based on an open two-compartment model and a noncompartmental technique . At the end of infusion , the mean concentrations of imipenem and meropenem measured in serum were 61.2 +/- 9.8 and 51.6 +/- 6.5 mg/liter , respectively ; urinary recoveries were 48.6 % +/- 8.2 % and 60.0 % +/- 6.5 % of the dose in 12 h , respectively ; and the areas under the concentration-time curve from time zero to infinity were 96.1 +/- 14.4 and 70.5 +/- 10.3 mg.h/liter , respectively ( P < or = 0.02 ) . Imipenem had a mean half-life of 66.7 +/- 10.4 min ; that of meropenem was 64.4 +/- 6.9 min . The volumes of distribution at steady state of imipenem and meropenem were 15.3 +/- 3.3 and 18.6 +/- 3.0 liters/70 kg , respectively , and the mean renal clearances per 1.73 m2 were 85.6 +/- 17.6 and 144.6 +/- 26.0 ml/min , respectively . Both antibiotics were well tolerated in this single-dose administration study . The SBAs were measured by the microdilution method of Reller and Stratton ( L. B. Reller and C. W. Stratton , J. Infect . Dis . 136:196-204 , 1977 ) against 40 clinically isolated strains . Mean reciprocal bactericidal titers were measured 1 and 6 h after administration . After 1 and 6 h the median SBAs for imipenem and meropenem , were 409 and 34.9 and 97.9 and 5.8 , respectively , against Staphylococcus aureus , 19.9 and 4.4 and 19.4 and 4.8 , respectively , against Pseudomonas aeruginosa , 34.3 and 2.2 and 232 and 15.5 , respectively , against Enterobacter cloacae , and 13.4 and 2.25 and 90.7 and 7.9 , respectively , against Proteus mirabilis . Both drugs had rather short biological elimination half-lives and a predominantly renal route of elimination . Both carbapenems revealed high SBAs against clinically important pathogens at 1 h ; meropenem had a higher SBA against E. cloacae and P. mirabilis , and the SBA of imipenem against S. aureus was greater than the SBA of meropenem . Instructions: please extract entity words from the input sentence

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Serum bactericidal activities and comparative pharmacokinetics of meropenem and imipenem-cilastatin . The pharmacokinetics and serum bactericidal activities ( SBAs ) of imipenem and meropenem were investigated in a randomized crossover study . Twelve healthy male volunteers received a constant 30-min infusion of either 1 g of imipenem plus 1 g of cilastatin or 1 g of meropenem . The concentrations of the drugs in serum and urine were determined by bioassay and high-pressure liquid chromatography . Pharmacokinetic parameters were based on an open two-compartment model and a noncompartmental technique . At the end of infusion , the mean concentrations of imipenem and meropenem measured in serum were 61.2 +/- 9.8 and 51.6 +/- 6.5 mg/liter , respectively ; urinary recoveries were 48.6 % +/- 8.2 % and 60.0 % +/- 6.5 % of the dose in 12 h , respectively ; and the areas under the concentration-time curve from time zero to infinity were 96.1 +/- 14.4 and 70.5 +/- 10.3 mg.h/liter , respectively ( P < or = 0.02 ) . Imipenem had a mean half-life of 66.7 +/- 10.4 min ; that of meropenem was 64.4 +/- 6.9 min . The volumes of distribution at steady state of imipenem and meropenem were 15.3 +/- 3.3 and 18.6 +/- 3.0 liters/70 kg , respectively , and the mean renal clearances per 1.73 m2 were 85.6 +/- 17.6 and 144.6 +/- 26.0 ml/min , respectively . Both antibiotics were well tolerated in this single-dose administration study . The SBAs were measured by the microdilution method of Reller and Stratton ( L. B. Reller and C. W. Stratton , J. Infect . Dis . 136:196-204 , 1977 ) against 40 clinically isolated strains . Mean reciprocal bactericidal titers were measured 1 and 6 h after administration . After 1 and 6 h the median SBAs for imipenem and meropenem , were 409 and 34.9 and 97.9 and 5.8 , respectively , against Staphylococcus aureus , 19.9 and 4.4 and 19.4 and 4.8 , respectively , against Pseudomonas aeruginosa , 34.3 and 2.2 and 232 and 15.5 , respectively , against Enterobacter cloacae , and 13.4 and 2.25 and 90.7 and 7.9 , respectively , against Proteus mirabilis . Both drugs had rather short biological elimination half-lives and a predominantly renal route of elimination . Both carbapenems revealed high SBAs against clinically important pathogens at 1 h ; meropenem had a higher SBA against E. cloacae and P. mirabilis , and the SBA of imipenem against S. aureus was greater than the SBA of meropenem .

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[ "Outcome_Physical", "Outcome_Other", "Intervention_Physical", "Intervention_Pharmacological", "Participant_Condition" ]

Lippendefekten is an umlsterm, Mundsphinkters is an umlsterm, Literatur is an umlsterm, Techniken is an umlsterm, Wiederherstellung is an umlsterm, Lippendefekten is an umlsterm, Lippen is an umlsterm, Arbeit is an umlsterm, Lippenrotdefekte is an umlsterm, Lippen is an umlsterm

HNO.00480517.ger.abstr_task0

Sentence: Die Rekonstruktion von Lippendefekten stellt eine Herausforderung fuer den Operateur dar . Neben den guten aesthetischen Ergebnissen ist die Erhaltung der Funktionen des Mundsphinkters erforderlich . In der Literatur werden verschiedene Techniken und Modifikationen zur Wiederherstellung von Lippendefekten angegeben . Es bleibt dem Operateur ueberlassen , abhaengig von der Lokalisation , Groesse und Tiefe des Defekts , das Rekonstruktionsverfahren mit den besten funktionellen und aesthetischen Ergebnissen auszuwaehlen . Die Unterteilung der Lippen in aesthetische Untereinheiten kann sehr vorteilhaft bei der Planung der Rekonstruktion sein . Die Oberlippe wird in 3 aesthetische Untereinheiten unterteilt 2 laterale Untereinheiten und 1 mediane , : das Philtrum . Die Unterlippe besteht aus einer aesthetischen Untereinheit . In dieser Arbeit werden bewaehrte Rekonstruktionstechniken erlaeutert und ein Konzept vorgestellt , das die Wahl des jeweils adaequaten Verfahrens erleichtern soll . In diesem Konzept unterscheiden wir reine Lippenrotdefekte von partiellen und kompletten Defekten der Lippen . Die kompletten Defekte werden bei der Unterlippe in Defekte bis zu 1/3 , 1/3 bis 2/3 der Unterlippenbreite und zwischen 2/3 und totalem Substanzverlust unterteilt . Bei der Oberlippe unterscheiden wir isolierte Defekte der zentralen und lateralen Untereinheit und kombinierte Defekte der zentralen und lateralen Untereinheit . Wichtige Operationsprinzipien sowie die Vor- und Nachteile verschiedener Rekonstruktionstechniken werden diskutiert . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Die Rekonstruktion von Lippendefekten stellt eine Herausforderung fuer den Operateur dar . Neben den guten aesthetischen Ergebnissen ist die Erhaltung der Funktionen des Mundsphinkters erforderlich . In der Literatur werden verschiedene Techniken und Modifikationen zur Wiederherstellung von Lippendefekten angegeben . Es bleibt dem Operateur ueberlassen , abhaengig von der Lokalisation , Groesse und Tiefe des Defekts , das Rekonstruktionsverfahren mit den besten funktionellen und aesthetischen Ergebnissen auszuwaehlen . Die Unterteilung der Lippen in aesthetische Untereinheiten kann sehr vorteilhaft bei der Planung der Rekonstruktion sein . Die Oberlippe wird in 3 aesthetische Untereinheiten unterteilt 2 laterale Untereinheiten und 1 mediane , : das Philtrum . Die Unterlippe besteht aus einer aesthetischen Untereinheit . In dieser Arbeit werden bewaehrte Rekonstruktionstechniken erlaeutert und ein Konzept vorgestellt , das die Wahl des jeweils adaequaten Verfahrens erleichtern soll . In diesem Konzept unterscheiden wir reine Lippenrotdefekte von partiellen und kompletten Defekten der Lippen . Die kompletten Defekte werden bei der Unterlippe in Defekte bis zu 1/3 , 1/3 bis 2/3 der Unterlippenbreite und zwischen 2/3 und totalem Substanzverlust unterteilt . Bei der Oberlippe unterscheiden wir isolierte Defekte der zentralen und lateralen Untereinheit und kombinierte Defekte der zentralen und lateralen Untereinheit . Wichtige Operationsprinzipien sowie die Vor- und Nachteile verschiedener Rekonstruktionstechniken werden diskutiert .

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Lippendefekten is an umlsterm, Mundsphinkters is an umlsterm, Literatur is an umlsterm, Techniken is an umlsterm, Wiederherstellung is an umlsterm, Lippendefekten is an umlsterm, Lippen is an umlsterm, Arbeit is an umlsterm, Lippenrotdefekte is an umlsterm, Lippen is an umlsterm

HNO.00480517.ger.abstr_task1

Sentence: Die Rekonstruktion von Lippendefekten stellt eine Herausforderung fuer den Operateur dar . Neben den guten aesthetischen Ergebnissen ist die Erhaltung der Funktionen des Mundsphinkters erforderlich . In der Literatur werden verschiedene Techniken und Modifikationen zur Wiederherstellung von Lippendefekten angegeben . Es bleibt dem Operateur ueberlassen , abhaengig von der Lokalisation , Groesse und Tiefe des Defekts , das Rekonstruktionsverfahren mit den besten funktionellen und aesthetischen Ergebnissen auszuwaehlen . Die Unterteilung der Lippen in aesthetische Untereinheiten kann sehr vorteilhaft bei der Planung der Rekonstruktion sein . Die Oberlippe wird in 3 aesthetische Untereinheiten unterteilt 2 laterale Untereinheiten und 1 mediane , : das Philtrum . Die Unterlippe besteht aus einer aesthetischen Untereinheit . In dieser Arbeit werden bewaehrte Rekonstruktionstechniken erlaeutert und ein Konzept vorgestellt , das die Wahl des jeweils adaequaten Verfahrens erleichtern soll . In diesem Konzept unterscheiden wir reine Lippenrotdefekte von partiellen und kompletten Defekten der Lippen . Die kompletten Defekte werden bei der Unterlippe in Defekte bis zu 1/3 , 1/3 bis 2/3 der Unterlippenbreite und zwischen 2/3 und totalem Substanzverlust unterteilt . Bei der Oberlippe unterscheiden wir isolierte Defekte der zentralen und lateralen Untereinheit und kombinierte Defekte der zentralen und lateralen Untereinheit . Wichtige Operationsprinzipien sowie die Vor- und Nachteile verschiedener Rekonstruktionstechniken werden diskutiert . Instructions: please typing these entity words according to sentence: Lippendefekten, Mundsphinkters, Literatur, Techniken, Wiederherstellung, Lippendefekten, Lippen, Arbeit, Lippenrotdefekte, Lippen Options: umlsterm

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Die Rekonstruktion von Lippendefekten stellt eine Herausforderung fuer den Operateur dar . Neben den guten aesthetischen Ergebnissen ist die Erhaltung der Funktionen des Mundsphinkters erforderlich . In der Literatur werden verschiedene Techniken und Modifikationen zur Wiederherstellung von Lippendefekten angegeben . Es bleibt dem Operateur ueberlassen , abhaengig von der Lokalisation , Groesse und Tiefe des Defekts , das Rekonstruktionsverfahren mit den besten funktionellen und aesthetischen Ergebnissen auszuwaehlen . Die Unterteilung der Lippen in aesthetische Untereinheiten kann sehr vorteilhaft bei der Planung der Rekonstruktion sein . Die Oberlippe wird in 3 aesthetische Untereinheiten unterteilt 2 laterale Untereinheiten und 1 mediane , : das Philtrum . Die Unterlippe besteht aus einer aesthetischen Untereinheit . In dieser Arbeit werden bewaehrte Rekonstruktionstechniken erlaeutert und ein Konzept vorgestellt , das die Wahl des jeweils adaequaten Verfahrens erleichtern soll . In diesem Konzept unterscheiden wir reine Lippenrotdefekte von partiellen und kompletten Defekten der Lippen . Die kompletten Defekte werden bei der Unterlippe in Defekte bis zu 1/3 , 1/3 bis 2/3 der Unterlippenbreite und zwischen 2/3 und totalem Substanzverlust unterteilt . Bei der Oberlippe unterscheiden wir isolierte Defekte der zentralen und lateralen Untereinheit und kombinierte Defekte der zentralen und lateralen Untereinheit . Wichtige Operationsprinzipien sowie die Vor- und Nachteile verschiedener Rekonstruktionstechniken werden diskutiert .

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[ "umlsterm" ]

Lippendefekten, Mundsphinkters, Literatur, Techniken, Wiederherstellung, Lippendefekten, Lippen, Arbeit, Lippenrotdefekte, Lippen

HNO.00480517.ger.abstr_task2

Sentence: Die Rekonstruktion von Lippendefekten stellt eine Herausforderung fuer den Operateur dar . Neben den guten aesthetischen Ergebnissen ist die Erhaltung der Funktionen des Mundsphinkters erforderlich . In der Literatur werden verschiedene Techniken und Modifikationen zur Wiederherstellung von Lippendefekten angegeben . Es bleibt dem Operateur ueberlassen , abhaengig von der Lokalisation , Groesse und Tiefe des Defekts , das Rekonstruktionsverfahren mit den besten funktionellen und aesthetischen Ergebnissen auszuwaehlen . Die Unterteilung der Lippen in aesthetische Untereinheiten kann sehr vorteilhaft bei der Planung der Rekonstruktion sein . Die Oberlippe wird in 3 aesthetische Untereinheiten unterteilt 2 laterale Untereinheiten und 1 mediane , : das Philtrum . Die Unterlippe besteht aus einer aesthetischen Untereinheit . In dieser Arbeit werden bewaehrte Rekonstruktionstechniken erlaeutert und ein Konzept vorgestellt , das die Wahl des jeweils adaequaten Verfahrens erleichtern soll . In diesem Konzept unterscheiden wir reine Lippenrotdefekte von partiellen und kompletten Defekten der Lippen . Die kompletten Defekte werden bei der Unterlippe in Defekte bis zu 1/3 , 1/3 bis 2/3 der Unterlippenbreite und zwischen 2/3 und totalem Substanzverlust unterteilt . Bei der Oberlippe unterscheiden wir isolierte Defekte der zentralen und lateralen Untereinheit und kombinierte Defekte der zentralen und lateralen Untereinheit . Wichtige Operationsprinzipien sowie die Vor- und Nachteile verschiedener Rekonstruktionstechniken werden diskutiert . Instructions: please extract entity words from the input sentence

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Die Rekonstruktion von Lippendefekten stellt eine Herausforderung fuer den Operateur dar . Neben den guten aesthetischen Ergebnissen ist die Erhaltung der Funktionen des Mundsphinkters erforderlich . In der Literatur werden verschiedene Techniken und Modifikationen zur Wiederherstellung von Lippendefekten angegeben . Es bleibt dem Operateur ueberlassen , abhaengig von der Lokalisation , Groesse und Tiefe des Defekts , das Rekonstruktionsverfahren mit den besten funktionellen und aesthetischen Ergebnissen auszuwaehlen . Die Unterteilung der Lippen in aesthetische Untereinheiten kann sehr vorteilhaft bei der Planung der Rekonstruktion sein . Die Oberlippe wird in 3 aesthetische Untereinheiten unterteilt 2 laterale Untereinheiten und 1 mediane , : das Philtrum . Die Unterlippe besteht aus einer aesthetischen Untereinheit . In dieser Arbeit werden bewaehrte Rekonstruktionstechniken erlaeutert und ein Konzept vorgestellt , das die Wahl des jeweils adaequaten Verfahrens erleichtern soll . In diesem Konzept unterscheiden wir reine Lippenrotdefekte von partiellen und kompletten Defekten der Lippen . Die kompletten Defekte werden bei der Unterlippe in Defekte bis zu 1/3 , 1/3 bis 2/3 der Unterlippenbreite und zwischen 2/3 und totalem Substanzverlust unterteilt . Bei der Oberlippe unterscheiden wir isolierte Defekte der zentralen und lateralen Untereinheit und kombinierte Defekte der zentralen und lateralen Untereinheit . Wichtige Operationsprinzipien sowie die Vor- und Nachteile verschiedener Rekonstruktionstechniken werden diskutiert .

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[ "umlsterm" ]

Catalpol is a CHEMICAL, oxygen is a CHEMICAL, catalpol is a CHEMICAL, Catalpol is a CHEMICAL, monocyte chemotactic protein-1 is a GENE-Y, MCP-1 is a GENE-Y, tumor necrosis factor - α is a GENE-Y, TNF - α is a GENE-Y, inducible NO synthase is a GENE-Y, iNOS is a GENE-Y, receptor for AGE is a GENE-Y, RAGE is a GENE-Y, NF - κB is a GENE-N, catalpol is a CHEMICAL, AP-1 is a GENE-Y, Catalpol is a CHEMICAL, mitogen activated protein ( MAP ) kinases is a GENE-N, IκBα is a GENE-Y, oxygen is a CHEMICAL, catalpol is a CHEMICAL, NADPH oxidase is a GENE-N, catalpol is a CHEMICAL, NF - κB is a GENE-N, catalpol is a CHEMICAL

26385_task0

Sentence: Catalpol suppresses advanced glycation end-products-induced inflammatory responses through inhibition of reactive oxygen species in human monocytic THP-1 cells. Advanced glycation end-products (AGEs) play a pivotal role in the development of diabetic complications by inducing inflammation. We previously reported that the fresh roots of Rehmannia glutinosa Libosch., which have been used for the treatment of diabetes in traditional Korean medicine, also have the potential to suppress AGE-mediated inflammatory response in THP-1 cells. In the present study, we isolated catalpol from R. glutinosa, and examined whether it has anti-inflammatory effects on AGE-stimulated THP-1 cells. Catalpol reduced the expression of pro-inflammatory mediates, such as monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor-α (TNF-α), inducible NO synthase (iNOS), and receptor for AGE (RAGE). Promoter and electromobility shift assays showed that transcriptional activation of NF-κB was significantly reduced by catalpol treatment, while AP-1 was not. Catalpol also suppressed AGE-induced phosphorylation of mitogen activated protein (MAP) kinases, degradation of IκBα and the nuclear localization of NF-κB. Moreover, the production of intracellular reactive oxygen species (ROS) elicited by AGE was also suppressed by catalpol treatment, through dual action of reducing ROS itself and inhibiting NADPH oxidase activity. Our findings indicate that catalpol suppresses AGE-mediated inflammation by inhibiting ROS production and NF-κB activity. We suggest that catalpol, a major constituent of the fresh roots of R. glutinosa, contributes to the prevention of AGE-mediated diabetic complications. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N, GENE-Y, CHEMICAL

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Catalpol suppresses advanced glycation end-products-induced inflammatory responses through inhibition of reactive oxygen species in human monocytic THP-1 cells. Advanced glycation end-products (AGEs) play a pivotal role in the development of diabetic complications by inducing inflammation. We previously reported that the fresh roots of Rehmannia glutinosa Libosch., which have been used for the treatment of diabetes in traditional Korean medicine, also have the potential to suppress AGE-mediated inflammatory response in THP-1 cells. In the present study, we isolated catalpol from R. glutinosa, and examined whether it has anti-inflammatory effects on AGE-stimulated THP-1 cells. Catalpol reduced the expression of pro-inflammatory mediates, such as monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor-α (TNF-α), inducible NO synthase (iNOS), and receptor for AGE (RAGE). Promoter and electromobility shift assays showed that transcriptional activation of NF-κB was significantly reduced by catalpol treatment, while AP-1 was not. Catalpol also suppressed AGE-induced phosphorylation of mitogen activated protein (MAP) kinases, degradation of IκBα and the nuclear localization of NF-κB. Moreover, the production of intracellular reactive oxygen species (ROS) elicited by AGE was also suppressed by catalpol treatment, through dual action of reducing ROS itself and inhibiting NADPH oxidase activity. Our findings indicate that catalpol suppresses AGE-mediated inflammation by inhibiting ROS production and NF-κB activity. We suggest that catalpol, a major constituent of the fresh roots of R. glutinosa, contributes to the prevention of AGE-mediated diabetic complications.

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[ "GENE-N", "GENE-Y", "CHEMICAL" ]

Catalpol is a CHEMICAL, oxygen is a CHEMICAL, catalpol is a CHEMICAL, Catalpol is a CHEMICAL, monocyte chemotactic protein-1 is a GENE-Y, MCP-1 is a GENE-Y, tumor necrosis factor - α is a GENE-Y, TNF - α is a GENE-Y, inducible NO synthase is a GENE-Y, iNOS is a GENE-Y, receptor for AGE is a GENE-Y, RAGE is a GENE-Y, NF - κB is a GENE-N, catalpol is a CHEMICAL, AP-1 is a GENE-Y, Catalpol is a CHEMICAL, mitogen activated protein ( MAP ) kinases is a GENE-N, IκBα is a GENE-Y, oxygen is a CHEMICAL, catalpol is a CHEMICAL, NADPH oxidase is a GENE-N, catalpol is a CHEMICAL, NF - κB is a GENE-N, catalpol is a CHEMICAL

26385_task1

Sentence: Catalpol suppresses advanced glycation end-products-induced inflammatory responses through inhibition of reactive oxygen species in human monocytic THP-1 cells. Advanced glycation end-products (AGEs) play a pivotal role in the development of diabetic complications by inducing inflammation. We previously reported that the fresh roots of Rehmannia glutinosa Libosch., which have been used for the treatment of diabetes in traditional Korean medicine, also have the potential to suppress AGE-mediated inflammatory response in THP-1 cells. In the present study, we isolated catalpol from R. glutinosa, and examined whether it has anti-inflammatory effects on AGE-stimulated THP-1 cells. Catalpol reduced the expression of pro-inflammatory mediates, such as monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor-α (TNF-α), inducible NO synthase (iNOS), and receptor for AGE (RAGE). Promoter and electromobility shift assays showed that transcriptional activation of NF-κB was significantly reduced by catalpol treatment, while AP-1 was not. Catalpol also suppressed AGE-induced phosphorylation of mitogen activated protein (MAP) kinases, degradation of IκBα and the nuclear localization of NF-κB. Moreover, the production of intracellular reactive oxygen species (ROS) elicited by AGE was also suppressed by catalpol treatment, through dual action of reducing ROS itself and inhibiting NADPH oxidase activity. Our findings indicate that catalpol suppresses AGE-mediated inflammation by inhibiting ROS production and NF-κB activity. We suggest that catalpol, a major constituent of the fresh roots of R. glutinosa, contributes to the prevention of AGE-mediated diabetic complications. Instructions: please typing these entity words according to sentence: Catalpol, oxygen, catalpol, Catalpol, monocyte chemotactic protein-1, MCP-1, tumor necrosis factor - α, TNF - α, inducible NO synthase, iNOS, receptor for AGE, RAGE, NF - κB, catalpol, AP-1, Catalpol, mitogen activated protein ( MAP ) kinases, IκBα, oxygen, catalpol, NADPH oxidase, catalpol, NF - κB, catalpol Options: GENE-N, GENE-Y, CHEMICAL

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Catalpol suppresses advanced glycation end-products-induced inflammatory responses through inhibition of reactive oxygen species in human monocytic THP-1 cells. Advanced glycation end-products (AGEs) play a pivotal role in the development of diabetic complications by inducing inflammation. We previously reported that the fresh roots of Rehmannia glutinosa Libosch., which have been used for the treatment of diabetes in traditional Korean medicine, also have the potential to suppress AGE-mediated inflammatory response in THP-1 cells. In the present study, we isolated catalpol from R. glutinosa, and examined whether it has anti-inflammatory effects on AGE-stimulated THP-1 cells. Catalpol reduced the expression of pro-inflammatory mediates, such as monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor-α (TNF-α), inducible NO synthase (iNOS), and receptor for AGE (RAGE). Promoter and electromobility shift assays showed that transcriptional activation of NF-κB was significantly reduced by catalpol treatment, while AP-1 was not. Catalpol also suppressed AGE-induced phosphorylation of mitogen activated protein (MAP) kinases, degradation of IκBα and the nuclear localization of NF-κB. Moreover, the production of intracellular reactive oxygen species (ROS) elicited by AGE was also suppressed by catalpol treatment, through dual action of reducing ROS itself and inhibiting NADPH oxidase activity. Our findings indicate that catalpol suppresses AGE-mediated inflammation by inhibiting ROS production and NF-κB activity. We suggest that catalpol, a major constituent of the fresh roots of R. glutinosa, contributes to the prevention of AGE-mediated diabetic complications.

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[ "GENE-N", "GENE-Y", "CHEMICAL" ]

Catalpol, oxygen, catalpol, Catalpol, monocyte chemotactic protein-1, MCP-1, tumor necrosis factor - α, TNF - α, inducible NO synthase, iNOS, receptor for AGE, RAGE, NF - κB, catalpol, AP-1, Catalpol, mitogen activated protein ( MAP ) kinases, IκBα, oxygen, catalpol, NADPH oxidase, catalpol, NF - κB, catalpol

26385_task2

Sentence: Catalpol suppresses advanced glycation end-products-induced inflammatory responses through inhibition of reactive oxygen species in human monocytic THP-1 cells. Advanced glycation end-products (AGEs) play a pivotal role in the development of diabetic complications by inducing inflammation. We previously reported that the fresh roots of Rehmannia glutinosa Libosch., which have been used for the treatment of diabetes in traditional Korean medicine, also have the potential to suppress AGE-mediated inflammatory response in THP-1 cells. In the present study, we isolated catalpol from R. glutinosa, and examined whether it has anti-inflammatory effects on AGE-stimulated THP-1 cells. Catalpol reduced the expression of pro-inflammatory mediates, such as monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor-α (TNF-α), inducible NO synthase (iNOS), and receptor for AGE (RAGE). Promoter and electromobility shift assays showed that transcriptional activation of NF-κB was significantly reduced by catalpol treatment, while AP-1 was not. Catalpol also suppressed AGE-induced phosphorylation of mitogen activated protein (MAP) kinases, degradation of IκBα and the nuclear localization of NF-κB. Moreover, the production of intracellular reactive oxygen species (ROS) elicited by AGE was also suppressed by catalpol treatment, through dual action of reducing ROS itself and inhibiting NADPH oxidase activity. Our findings indicate that catalpol suppresses AGE-mediated inflammation by inhibiting ROS production and NF-κB activity. We suggest that catalpol, a major constituent of the fresh roots of R. glutinosa, contributes to the prevention of AGE-mediated diabetic complications. Instructions: please extract entity words from the input sentence

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Catalpol suppresses advanced glycation end-products-induced inflammatory responses through inhibition of reactive oxygen species in human monocytic THP-1 cells. Advanced glycation end-products (AGEs) play a pivotal role in the development of diabetic complications by inducing inflammation. We previously reported that the fresh roots of Rehmannia glutinosa Libosch., which have been used for the treatment of diabetes in traditional Korean medicine, also have the potential to suppress AGE-mediated inflammatory response in THP-1 cells. In the present study, we isolated catalpol from R. glutinosa, and examined whether it has anti-inflammatory effects on AGE-stimulated THP-1 cells. Catalpol reduced the expression of pro-inflammatory mediates, such as monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor-α (TNF-α), inducible NO synthase (iNOS), and receptor for AGE (RAGE). Promoter and electromobility shift assays showed that transcriptional activation of NF-κB was significantly reduced by catalpol treatment, while AP-1 was not. Catalpol also suppressed AGE-induced phosphorylation of mitogen activated protein (MAP) kinases, degradation of IκBα and the nuclear localization of NF-κB. Moreover, the production of intracellular reactive oxygen species (ROS) elicited by AGE was also suppressed by catalpol treatment, through dual action of reducing ROS itself and inhibiting NADPH oxidase activity. Our findings indicate that catalpol suppresses AGE-mediated inflammation by inhibiting ROS production and NF-κB activity. We suggest that catalpol, a major constituent of the fresh roots of R. glutinosa, contributes to the prevention of AGE-mediated diabetic complications.

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[ "GENE-N", "GENE-Y", "CHEMICAL" ]

Transient lower esophageal sphincter relaxations ( TLESRs ) is a Outcome_Physical, loxiglumide is a Intervention_Pharmacological, Eight is a Participant_Sample-size, healthy subjects underwent esophageal manometry using a 10-lumen sleeve assembly during placebo or loxiglumide ( 10 mg / kg / h ) in is a Participant_Condition, Basal lower esophageal pressure ( LESP ) is a Outcome_Physical, swallow - induced relaxation is a Outcome_Physical, number of common cavities is a Outcome_Physical

92761_task0

Sentence: Involvement of cholecystokininA receptors in transient lower esophageal sphincter relaxations triggered by gastric distension . OBJECTIVE Transient lower esophageal sphincter relaxations ( TLESRs ) are the main mechanism underlying gastroesophageal reflux . In the present study we evaluated the effect of loxiglumide , a specific cholecystokininA ( CCKA ) -receptor antagonist , on the occurrence of TLESRs evoked by gastric distension . METHODS Eight healthy subjects underwent esophageal manometry using a 10-lumen sleeve assembly during placebo or loxiglumide ( 10 mg/kg/h ) in a randomized double-blind order . Gastric distension was induced by inflation of 400 ml of air . RESULTS Basal lower esophageal pressure ( LESP ) and swallow-induced relaxation were not affected by loxiglumide . Loxiglumide significantly reduced the number of TLESRs , from 11.5 ( 5.8-18.3 ) to 6.0 ( 3.3-14.3 ) during the total recording period of 1 h , and from 5.5 ( 4.25-7.5 ) to 2.0 ( 0.5-6.8 ) during the first 15 min . The number of common cavities was significantly decreased by loxiglumide , from 8.0 ( 4.0-20.0 ) to 5.0 ( 2.0-7.8 ) . TLESRs represented the main mechanism ( 60 % during placebo , 74 % during loxiglumide ) underlying common cavities , followed by swallow-induced relaxation . CONCLUSIONS Loxiglumide significantly reduces the number of TLESRs triggered by gastric distension without interfering with swallow-related relaxation of the lower esophageal sphincter , suggesting the involvement of CCKA receptors in the reflex pathway mediating TLESRs . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Outcome_Physical, Participant_Condition, Participant_Sample-size

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Involvement of cholecystokininA receptors in transient lower esophageal sphincter relaxations triggered by gastric distension . OBJECTIVE Transient lower esophageal sphincter relaxations ( TLESRs ) are the main mechanism underlying gastroesophageal reflux . In the present study we evaluated the effect of loxiglumide , a specific cholecystokininA ( CCKA ) -receptor antagonist , on the occurrence of TLESRs evoked by gastric distension . METHODS Eight healthy subjects underwent esophageal manometry using a 10-lumen sleeve assembly during placebo or loxiglumide ( 10 mg/kg/h ) in a randomized double-blind order . Gastric distension was induced by inflation of 400 ml of air . RESULTS Basal lower esophageal pressure ( LESP ) and swallow-induced relaxation were not affected by loxiglumide . Loxiglumide significantly reduced the number of TLESRs , from 11.5 ( 5.8-18.3 ) to 6.0 ( 3.3-14.3 ) during the total recording period of 1 h , and from 5.5 ( 4.25-7.5 ) to 2.0 ( 0.5-6.8 ) during the first 15 min . The number of common cavities was significantly decreased by loxiglumide , from 8.0 ( 4.0-20.0 ) to 5.0 ( 2.0-7.8 ) . TLESRs represented the main mechanism ( 60 % during placebo , 74 % during loxiglumide ) underlying common cavities , followed by swallow-induced relaxation . CONCLUSIONS Loxiglumide significantly reduces the number of TLESRs triggered by gastric distension without interfering with swallow-related relaxation of the lower esophageal sphincter , suggesting the involvement of CCKA receptors in the reflex pathway mediating TLESRs .

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[ "Participant_Condition", "Outcome_Physical", "Intervention_Physical", "Intervention_Pharmacological", "Participant_Sample-size" ]

Transient lower esophageal sphincter relaxations ( TLESRs ) is a Outcome_Physical, loxiglumide is a Intervention_Pharmacological, Eight is a Participant_Sample-size, healthy subjects underwent esophageal manometry using a 10-lumen sleeve assembly during placebo or loxiglumide ( 10 mg / kg / h ) in is a Participant_Condition, Basal lower esophageal pressure ( LESP ) is a Outcome_Physical, swallow - induced relaxation is a Outcome_Physical, number of common cavities is a Outcome_Physical

92761_task1

Sentence: Involvement of cholecystokininA receptors in transient lower esophageal sphincter relaxations triggered by gastric distension . OBJECTIVE Transient lower esophageal sphincter relaxations ( TLESRs ) are the main mechanism underlying gastroesophageal reflux . In the present study we evaluated the effect of loxiglumide , a specific cholecystokininA ( CCKA ) -receptor antagonist , on the occurrence of TLESRs evoked by gastric distension . METHODS Eight healthy subjects underwent esophageal manometry using a 10-lumen sleeve assembly during placebo or loxiglumide ( 10 mg/kg/h ) in a randomized double-blind order . Gastric distension was induced by inflation of 400 ml of air . RESULTS Basal lower esophageal pressure ( LESP ) and swallow-induced relaxation were not affected by loxiglumide . Loxiglumide significantly reduced the number of TLESRs , from 11.5 ( 5.8-18.3 ) to 6.0 ( 3.3-14.3 ) during the total recording period of 1 h , and from 5.5 ( 4.25-7.5 ) to 2.0 ( 0.5-6.8 ) during the first 15 min . The number of common cavities was significantly decreased by loxiglumide , from 8.0 ( 4.0-20.0 ) to 5.0 ( 2.0-7.8 ) . TLESRs represented the main mechanism ( 60 % during placebo , 74 % during loxiglumide ) underlying common cavities , followed by swallow-induced relaxation . CONCLUSIONS Loxiglumide significantly reduces the number of TLESRs triggered by gastric distension without interfering with swallow-related relaxation of the lower esophageal sphincter , suggesting the involvement of CCKA receptors in the reflex pathway mediating TLESRs . Instructions: please typing these entity words according to sentence: Transient lower esophageal sphincter relaxations ( TLESRs ), loxiglumide, Eight, healthy subjects underwent esophageal manometry using a 10-lumen sleeve assembly during placebo or loxiglumide ( 10 mg / kg / h ) in, Basal lower esophageal pressure ( LESP ), swallow - induced relaxation, number of common cavities Options: Intervention_Pharmacological, Outcome_Physical, Participant_Condition, Participant_Sample-size

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Involvement of cholecystokininA receptors in transient lower esophageal sphincter relaxations triggered by gastric distension . OBJECTIVE Transient lower esophageal sphincter relaxations ( TLESRs ) are the main mechanism underlying gastroesophageal reflux . In the present study we evaluated the effect of loxiglumide , a specific cholecystokininA ( CCKA ) -receptor antagonist , on the occurrence of TLESRs evoked by gastric distension . METHODS Eight healthy subjects underwent esophageal manometry using a 10-lumen sleeve assembly during placebo or loxiglumide ( 10 mg/kg/h ) in a randomized double-blind order . Gastric distension was induced by inflation of 400 ml of air . RESULTS Basal lower esophageal pressure ( LESP ) and swallow-induced relaxation were not affected by loxiglumide . Loxiglumide significantly reduced the number of TLESRs , from 11.5 ( 5.8-18.3 ) to 6.0 ( 3.3-14.3 ) during the total recording period of 1 h , and from 5.5 ( 4.25-7.5 ) to 2.0 ( 0.5-6.8 ) during the first 15 min . The number of common cavities was significantly decreased by loxiglumide , from 8.0 ( 4.0-20.0 ) to 5.0 ( 2.0-7.8 ) . TLESRs represented the main mechanism ( 60 % during placebo , 74 % during loxiglumide ) underlying common cavities , followed by swallow-induced relaxation . CONCLUSIONS Loxiglumide significantly reduces the number of TLESRs triggered by gastric distension without interfering with swallow-related relaxation of the lower esophageal sphincter , suggesting the involvement of CCKA receptors in the reflex pathway mediating TLESRs .

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[ "Participant_Condition", "Outcome_Physical", "Intervention_Physical", "Intervention_Pharmacological", "Participant_Sample-size" ]

Transient lower esophageal sphincter relaxations ( TLESRs ), loxiglumide, Eight, healthy subjects underwent esophageal manometry using a 10-lumen sleeve assembly during placebo or loxiglumide ( 10 mg / kg / h ) in, Basal lower esophageal pressure ( LESP ), swallow - induced relaxation, number of common cavities

92761_task2

Sentence: Involvement of cholecystokininA receptors in transient lower esophageal sphincter relaxations triggered by gastric distension . OBJECTIVE Transient lower esophageal sphincter relaxations ( TLESRs ) are the main mechanism underlying gastroesophageal reflux . In the present study we evaluated the effect of loxiglumide , a specific cholecystokininA ( CCKA ) -receptor antagonist , on the occurrence of TLESRs evoked by gastric distension . METHODS Eight healthy subjects underwent esophageal manometry using a 10-lumen sleeve assembly during placebo or loxiglumide ( 10 mg/kg/h ) in a randomized double-blind order . Gastric distension was induced by inflation of 400 ml of air . RESULTS Basal lower esophageal pressure ( LESP ) and swallow-induced relaxation were not affected by loxiglumide . Loxiglumide significantly reduced the number of TLESRs , from 11.5 ( 5.8-18.3 ) to 6.0 ( 3.3-14.3 ) during the total recording period of 1 h , and from 5.5 ( 4.25-7.5 ) to 2.0 ( 0.5-6.8 ) during the first 15 min . The number of common cavities was significantly decreased by loxiglumide , from 8.0 ( 4.0-20.0 ) to 5.0 ( 2.0-7.8 ) . TLESRs represented the main mechanism ( 60 % during placebo , 74 % during loxiglumide ) underlying common cavities , followed by swallow-induced relaxation . CONCLUSIONS Loxiglumide significantly reduces the number of TLESRs triggered by gastric distension without interfering with swallow-related relaxation of the lower esophageal sphincter , suggesting the involvement of CCKA receptors in the reflex pathway mediating TLESRs . Instructions: please extract entity words from the input sentence

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Involvement of cholecystokininA receptors in transient lower esophageal sphincter relaxations triggered by gastric distension . OBJECTIVE Transient lower esophageal sphincter relaxations ( TLESRs ) are the main mechanism underlying gastroesophageal reflux . In the present study we evaluated the effect of loxiglumide , a specific cholecystokininA ( CCKA ) -receptor antagonist , on the occurrence of TLESRs evoked by gastric distension . METHODS Eight healthy subjects underwent esophageal manometry using a 10-lumen sleeve assembly during placebo or loxiglumide ( 10 mg/kg/h ) in a randomized double-blind order . Gastric distension was induced by inflation of 400 ml of air . RESULTS Basal lower esophageal pressure ( LESP ) and swallow-induced relaxation were not affected by loxiglumide . Loxiglumide significantly reduced the number of TLESRs , from 11.5 ( 5.8-18.3 ) to 6.0 ( 3.3-14.3 ) during the total recording period of 1 h , and from 5.5 ( 4.25-7.5 ) to 2.0 ( 0.5-6.8 ) during the first 15 min . The number of common cavities was significantly decreased by loxiglumide , from 8.0 ( 4.0-20.0 ) to 5.0 ( 2.0-7.8 ) . TLESRs represented the main mechanism ( 60 % during placebo , 74 % during loxiglumide ) underlying common cavities , followed by swallow-induced relaxation . CONCLUSIONS Loxiglumide significantly reduces the number of TLESRs triggered by gastric distension without interfering with swallow-related relaxation of the lower esophageal sphincter , suggesting the involvement of CCKA receptors in the reflex pathway mediating TLESRs .

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[ "Participant_Condition", "Outcome_Physical", "Intervention_Physical", "Intervention_Pharmacological", "Participant_Sample-size" ]

ICSI is an umlsterm, maennliche is an umlsterm, Methode is an umlsterm, ICSI is an umlsterm, Patienten is an umlsterm, Azoospermie is an umlsterm, Schwangerschaften is an umlsterm, Spermatogenesestoerungen is an umlsterm, Spermatozoen is an umlsterm, Hoden is an umlsterm, Injektion is an umlsterm, Spermatiden is an umlsterm, Spermatogenese is an umlsterm, Reproduktion is an umlsterm

DerUrologeA.90380575.ger.abstr_task0

Sentence: Mit der Einfuehrung der intrazytoplasmatischen Spermatozoeninjektion ( ICSI 1992 ) ist die schwere maennliche Subfertilitaet behandelbar geworden . Darueberhinaus konnte die Methode der ICSI auch bei Patienten mit Azoospermie durch die Anwendung der testikulaeren Spermatozoenextraktion ( TESE ) Schwangerschaften induzieren . Jedoch schwerste Spermatogenesestoerungen mit Reifungsarrest erfordern in Abwesenheit von reifen testikulaeren Spermatozoen im Hoden die intraooplasmatische Injektion von runden oder elongierten Spermatiden . Unter Zugrundelegung der Mechanismen der Spermatogenese und der genetischen Implikationen ihrer Fehlsteuerungen werden hier die Grenzen einer sinnvollen und erfolgreichen assistierten Reproduktion evident . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]

Mit der Einfuehrung der intrazytoplasmatischen Spermatozoeninjektion ( ICSI 1992 ) ist die schwere maennliche Subfertilitaet behandelbar geworden . Darueberhinaus konnte die Methode der ICSI auch bei Patienten mit Azoospermie durch die Anwendung der testikulaeren Spermatozoenextraktion ( TESE ) Schwangerschaften induzieren . Jedoch schwerste Spermatogenesestoerungen mit Reifungsarrest erfordern in Abwesenheit von reifen testikulaeren Spermatozoen im Hoden die intraooplasmatische Injektion von runden oder elongierten Spermatiden . Unter Zugrundelegung der Mechanismen der Spermatogenese und der genetischen Implikationen ihrer Fehlsteuerungen werden hier die Grenzen einer sinnvollen und erfolgreichen assistierten Reproduktion evident .

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[ "umlsterm" ]

ICSI is an umlsterm, maennliche is an umlsterm, Methode is an umlsterm, ICSI is an umlsterm, Patienten is an umlsterm, Azoospermie is an umlsterm, Schwangerschaften is an umlsterm, Spermatogenesestoerungen is an umlsterm, Spermatozoen is an umlsterm, Hoden is an umlsterm, Injektion is an umlsterm, Spermatiden is an umlsterm, Spermatogenese is an umlsterm, Reproduktion is an umlsterm

DerUrologeA.90380575.ger.abstr_task1

Sentence: Mit der Einfuehrung der intrazytoplasmatischen Spermatozoeninjektion ( ICSI 1992 ) ist die schwere maennliche Subfertilitaet behandelbar geworden . Darueberhinaus konnte die Methode der ICSI auch bei Patienten mit Azoospermie durch die Anwendung der testikulaeren Spermatozoenextraktion ( TESE ) Schwangerschaften induzieren . Jedoch schwerste Spermatogenesestoerungen mit Reifungsarrest erfordern in Abwesenheit von reifen testikulaeren Spermatozoen im Hoden die intraooplasmatische Injektion von runden oder elongierten Spermatiden . Unter Zugrundelegung der Mechanismen der Spermatogenese und der genetischen Implikationen ihrer Fehlsteuerungen werden hier die Grenzen einer sinnvollen und erfolgreichen assistierten Reproduktion evident . Instructions: please typing these entity words according to sentence: ICSI, maennliche, Methode, ICSI, Patienten, Azoospermie, Schwangerschaften, Spermatogenesestoerungen, Spermatozoen, Hoden, Injektion, Spermatiden, Spermatogenese, Reproduktion Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]

Mit der Einfuehrung der intrazytoplasmatischen Spermatozoeninjektion ( ICSI 1992 ) ist die schwere maennliche Subfertilitaet behandelbar geworden . Darueberhinaus konnte die Methode der ICSI auch bei Patienten mit Azoospermie durch die Anwendung der testikulaeren Spermatozoenextraktion ( TESE ) Schwangerschaften induzieren . Jedoch schwerste Spermatogenesestoerungen mit Reifungsarrest erfordern in Abwesenheit von reifen testikulaeren Spermatozoen im Hoden die intraooplasmatische Injektion von runden oder elongierten Spermatiden . Unter Zugrundelegung der Mechanismen der Spermatogenese und der genetischen Implikationen ihrer Fehlsteuerungen werden hier die Grenzen einer sinnvollen und erfolgreichen assistierten Reproduktion evident .

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[ "umlsterm" ]

ICSI, maennliche, Methode, ICSI, Patienten, Azoospermie, Schwangerschaften, Spermatogenesestoerungen, Spermatozoen, Hoden, Injektion, Spermatiden, Spermatogenese, Reproduktion

DerUrologeA.90380575.ger.abstr_task2

Sentence: Mit der Einfuehrung der intrazytoplasmatischen Spermatozoeninjektion ( ICSI 1992 ) ist die schwere maennliche Subfertilitaet behandelbar geworden . Darueberhinaus konnte die Methode der ICSI auch bei Patienten mit Azoospermie durch die Anwendung der testikulaeren Spermatozoenextraktion ( TESE ) Schwangerschaften induzieren . Jedoch schwerste Spermatogenesestoerungen mit Reifungsarrest erfordern in Abwesenheit von reifen testikulaeren Spermatozoen im Hoden die intraooplasmatische Injektion von runden oder elongierten Spermatiden . Unter Zugrundelegung der Mechanismen der Spermatogenese und der genetischen Implikationen ihrer Fehlsteuerungen werden hier die Grenzen einer sinnvollen und erfolgreichen assistierten Reproduktion evident . Instructions: please extract entity words from the input sentence

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Mit der Einfuehrung der intrazytoplasmatischen Spermatozoeninjektion ( ICSI 1992 ) ist die schwere maennliche Subfertilitaet behandelbar geworden . Darueberhinaus konnte die Methode der ICSI auch bei Patienten mit Azoospermie durch die Anwendung der testikulaeren Spermatozoenextraktion ( TESE ) Schwangerschaften induzieren . Jedoch schwerste Spermatogenesestoerungen mit Reifungsarrest erfordern in Abwesenheit von reifen testikulaeren Spermatozoen im Hoden die intraooplasmatische Injektion von runden oder elongierten Spermatiden . Unter Zugrundelegung der Mechanismen der Spermatogenese und der genetischen Implikationen ihrer Fehlsteuerungen werden hier die Grenzen einer sinnvollen und erfolgreichen assistierten Reproduktion evident .

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[ "umlsterm" ]

endometrial cancer is a Participant_Condition, 467 is a Participant_Sample-size, women is a Participant_Sex, type 1 or 2 endometrial cancer is a Participant_Condition, tumor is a Participant_Condition, type 1 endometrial cancer is a Participant_Condition, overall endometrial cancer risk is a Outcome_Physical, 9708/9905 , miRNA expression is a Outcome_Other, status is a Outcome_Other, Overall survival rates is a Outcome_Mortality, variant and wild - type alleles is a Participant_Condition

65129_task0

Sentence: The KRAS-variant and miRNA expression in RTOG endometrial cancer clinical trials 9708 and 9905 . OBJECTIVE To explore the association of a functional germline variant in the 3'-UTR of KRAS with endometrial cancer risk , as well as the association of microRNA ( miRNA ) signatures and the KRAS-variant with clinical characteristics and survival outcomes in two prospective RTOG endometrial cancer trials . METHODS/MATERIALS The association of the KRAS-variant with endometrial cancer risk was evaluated by case-control analysis of 467 women with type 1 or 2 endometrial cancer and 582 age-matched controls . miRNA and DNA were isolated for expression profiling and genotyping from tumor specimens of 46 women with type 1 endometrial cancer enrolled in RTOG trials 9708 and 9905. miRNA expression levels and KRAS-variant genotype were correlated with patient and tumor characteristics , and survival outcomes were evaluated by variant allele type . RESULTS The KRAS-variant was not significantly associated with overall endometrial cancer risk ( 14 % controls and 17 % type 1 cancers ) , although was enriched in type 2 endometrial cancers ( 24 % , p = 0.2 ) . In the combined analysis of RTOG 9708/9905 , miRNA expression differed by age , presence of lymphovascular invasion and KRAS-variant status . Overall survival rates at 3 years for patients with the variant and wild-type alleles were 100 % and 77 % ( HR 0.3 , p = 0.24 ) , respectively , favoring the variant . CONCLUSIONS The KRAS-variant may be a genetic marker of risk for type 2 endometrial cancers . In addition , tumor miRNA expression appears to be associated with patient age , lymphovascular invasion and the KRAS-variant , supporting the hypothesis that altered tumor biology can be measured by miRNA expression , and that the KRAS-variant likely impacts endometrial tumor biology . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Participant_Sex, Participant_Condition, Outcome_Mortality, Outcome_Physical, Participant_Sample-size, Outcome_Other

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The KRAS-variant and miRNA expression in RTOG endometrial cancer clinical trials 9708 and 9905 . OBJECTIVE To explore the association of a functional germline variant in the 3'-UTR of KRAS with endometrial cancer risk , as well as the association of microRNA ( miRNA ) signatures and the KRAS-variant with clinical characteristics and survival outcomes in two prospective RTOG endometrial cancer trials . METHODS/MATERIALS The association of the KRAS-variant with endometrial cancer risk was evaluated by case-control analysis of 467 women with type 1 or 2 endometrial cancer and 582 age-matched controls . miRNA and DNA were isolated for expression profiling and genotyping from tumor specimens of 46 women with type 1 endometrial cancer enrolled in RTOG trials 9708 and 9905. miRNA expression levels and KRAS-variant genotype were correlated with patient and tumor characteristics , and survival outcomes were evaluated by variant allele type . RESULTS The KRAS-variant was not significantly associated with overall endometrial cancer risk ( 14 % controls and 17 % type 1 cancers ) , although was enriched in type 2 endometrial cancers ( 24 % , p = 0.2 ) . In the combined analysis of RTOG 9708/9905 , miRNA expression differed by age , presence of lymphovascular invasion and KRAS-variant status . Overall survival rates at 3 years for patients with the variant and wild-type alleles were 100 % and 77 % ( HR 0.3 , p = 0.24 ) , respectively , favoring the variant . CONCLUSIONS The KRAS-variant may be a genetic marker of risk for type 2 endometrial cancers . In addition , tumor miRNA expression appears to be associated with patient age , lymphovascular invasion and the KRAS-variant , supporting the hypothesis that altered tumor biology can be measured by miRNA expression , and that the KRAS-variant likely impacts endometrial tumor biology .

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[ "Outcome_Physical", "Participant_Condition", "Outcome_Other", "Outcome_Mortality", "Participant_Sex", "Participant_Sample-size" ]

endometrial cancer is a Participant_Condition, 467 is a Participant_Sample-size, women is a Participant_Sex, type 1 or 2 endometrial cancer is a Participant_Condition, tumor is a Participant_Condition, type 1 endometrial cancer is a Participant_Condition, overall endometrial cancer risk is a Outcome_Physical, 9708/9905 , miRNA expression is a Outcome_Other, status is a Outcome_Other, Overall survival rates is a Outcome_Mortality, variant and wild - type alleles is a Participant_Condition

65129_task1

Sentence: The KRAS-variant and miRNA expression in RTOG endometrial cancer clinical trials 9708 and 9905 . OBJECTIVE To explore the association of a functional germline variant in the 3'-UTR of KRAS with endometrial cancer risk , as well as the association of microRNA ( miRNA ) signatures and the KRAS-variant with clinical characteristics and survival outcomes in two prospective RTOG endometrial cancer trials . METHODS/MATERIALS The association of the KRAS-variant with endometrial cancer risk was evaluated by case-control analysis of 467 women with type 1 or 2 endometrial cancer and 582 age-matched controls . miRNA and DNA were isolated for expression profiling and genotyping from tumor specimens of 46 women with type 1 endometrial cancer enrolled in RTOG trials 9708 and 9905. miRNA expression levels and KRAS-variant genotype were correlated with patient and tumor characteristics , and survival outcomes were evaluated by variant allele type . RESULTS The KRAS-variant was not significantly associated with overall endometrial cancer risk ( 14 % controls and 17 % type 1 cancers ) , although was enriched in type 2 endometrial cancers ( 24 % , p = 0.2 ) . In the combined analysis of RTOG 9708/9905 , miRNA expression differed by age , presence of lymphovascular invasion and KRAS-variant status . Overall survival rates at 3 years for patients with the variant and wild-type alleles were 100 % and 77 % ( HR 0.3 , p = 0.24 ) , respectively , favoring the variant . CONCLUSIONS The KRAS-variant may be a genetic marker of risk for type 2 endometrial cancers . In addition , tumor miRNA expression appears to be associated with patient age , lymphovascular invasion and the KRAS-variant , supporting the hypothesis that altered tumor biology can be measured by miRNA expression , and that the KRAS-variant likely impacts endometrial tumor biology . Instructions: please typing these entity words according to sentence: endometrial cancer, 467, women, type 1 or 2 endometrial cancer, tumor, type 1 endometrial cancer, overall endometrial cancer risk, 9708/9905 , miRNA expression, status, Overall survival rates, variant and wild - type alleles Options: Participant_Sex, Participant_Condition, Outcome_Mortality, Outcome_Physical, Participant_Sample-size, Outcome_Other

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The KRAS-variant and miRNA expression in RTOG endometrial cancer clinical trials 9708 and 9905 . OBJECTIVE To explore the association of a functional germline variant in the 3'-UTR of KRAS with endometrial cancer risk , as well as the association of microRNA ( miRNA ) signatures and the KRAS-variant with clinical characteristics and survival outcomes in two prospective RTOG endometrial cancer trials . METHODS/MATERIALS The association of the KRAS-variant with endometrial cancer risk was evaluated by case-control analysis of 467 women with type 1 or 2 endometrial cancer and 582 age-matched controls . miRNA and DNA were isolated for expression profiling and genotyping from tumor specimens of 46 women with type 1 endometrial cancer enrolled in RTOG trials 9708 and 9905. miRNA expression levels and KRAS-variant genotype were correlated with patient and tumor characteristics , and survival outcomes were evaluated by variant allele type . RESULTS The KRAS-variant was not significantly associated with overall endometrial cancer risk ( 14 % controls and 17 % type 1 cancers ) , although was enriched in type 2 endometrial cancers ( 24 % , p = 0.2 ) . In the combined analysis of RTOG 9708/9905 , miRNA expression differed by age , presence of lymphovascular invasion and KRAS-variant status . Overall survival rates at 3 years for patients with the variant and wild-type alleles were 100 % and 77 % ( HR 0.3 , p = 0.24 ) , respectively , favoring the variant . CONCLUSIONS The KRAS-variant may be a genetic marker of risk for type 2 endometrial cancers . In addition , tumor miRNA expression appears to be associated with patient age , lymphovascular invasion and the KRAS-variant , supporting the hypothesis that altered tumor biology can be measured by miRNA expression , and that the KRAS-variant likely impacts endometrial tumor biology .

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[ "Outcome_Physical", "Participant_Condition", "Outcome_Other", "Outcome_Mortality", "Participant_Sex", "Participant_Sample-size" ]

endometrial cancer, 467, women, type 1 or 2 endometrial cancer, tumor, type 1 endometrial cancer, overall endometrial cancer risk, 9708/9905 , miRNA expression, status, Overall survival rates, variant and wild - type alleles

65129_task2

Sentence: The KRAS-variant and miRNA expression in RTOG endometrial cancer clinical trials 9708 and 9905 . OBJECTIVE To explore the association of a functional germline variant in the 3'-UTR of KRAS with endometrial cancer risk , as well as the association of microRNA ( miRNA ) signatures and the KRAS-variant with clinical characteristics and survival outcomes in two prospective RTOG endometrial cancer trials . METHODS/MATERIALS The association of the KRAS-variant with endometrial cancer risk was evaluated by case-control analysis of 467 women with type 1 or 2 endometrial cancer and 582 age-matched controls . miRNA and DNA were isolated for expression profiling and genotyping from tumor specimens of 46 women with type 1 endometrial cancer enrolled in RTOG trials 9708 and 9905. miRNA expression levels and KRAS-variant genotype were correlated with patient and tumor characteristics , and survival outcomes were evaluated by variant allele type . RESULTS The KRAS-variant was not significantly associated with overall endometrial cancer risk ( 14 % controls and 17 % type 1 cancers ) , although was enriched in type 2 endometrial cancers ( 24 % , p = 0.2 ) . In the combined analysis of RTOG 9708/9905 , miRNA expression differed by age , presence of lymphovascular invasion and KRAS-variant status . Overall survival rates at 3 years for patients with the variant and wild-type alleles were 100 % and 77 % ( HR 0.3 , p = 0.24 ) , respectively , favoring the variant . CONCLUSIONS The KRAS-variant may be a genetic marker of risk for type 2 endometrial cancers . In addition , tumor miRNA expression appears to be associated with patient age , lymphovascular invasion and the KRAS-variant , supporting the hypothesis that altered tumor biology can be measured by miRNA expression , and that the KRAS-variant likely impacts endometrial tumor biology . Instructions: please extract entity words from the input sentence

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The KRAS-variant and miRNA expression in RTOG endometrial cancer clinical trials 9708 and 9905 . OBJECTIVE To explore the association of a functional germline variant in the 3'-UTR of KRAS with endometrial cancer risk , as well as the association of microRNA ( miRNA ) signatures and the KRAS-variant with clinical characteristics and survival outcomes in two prospective RTOG endometrial cancer trials . METHODS/MATERIALS The association of the KRAS-variant with endometrial cancer risk was evaluated by case-control analysis of 467 women with type 1 or 2 endometrial cancer and 582 age-matched controls . miRNA and DNA were isolated for expression profiling and genotyping from tumor specimens of 46 women with type 1 endometrial cancer enrolled in RTOG trials 9708 and 9905. miRNA expression levels and KRAS-variant genotype were correlated with patient and tumor characteristics , and survival outcomes were evaluated by variant allele type . RESULTS The KRAS-variant was not significantly associated with overall endometrial cancer risk ( 14 % controls and 17 % type 1 cancers ) , although was enriched in type 2 endometrial cancers ( 24 % , p = 0.2 ) . In the combined analysis of RTOG 9708/9905 , miRNA expression differed by age , presence of lymphovascular invasion and KRAS-variant status . Overall survival rates at 3 years for patients with the variant and wild-type alleles were 100 % and 77 % ( HR 0.3 , p = 0.24 ) , respectively , favoring the variant . CONCLUSIONS The KRAS-variant may be a genetic marker of risk for type 2 endometrial cancers . In addition , tumor miRNA expression appears to be associated with patient age , lymphovascular invasion and the KRAS-variant , supporting the hypothesis that altered tumor biology can be measured by miRNA expression , and that the KRAS-variant likely impacts endometrial tumor biology .

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[ "Outcome_Physical", "Participant_Condition", "Outcome_Other", "Outcome_Mortality", "Participant_Sex", "Participant_Sample-size" ]

oestrogenabhaengige is an umlsterm, Mammakarzinomen is an umlsterm, Therapie is an umlsterm, Mammakarzinomen is an umlsterm, formalinfixierten is an umlsterm, Paraffin is an umlsterm, Gewebeschnitten is an umlsterm, Konzentrationen is an umlsterm, Zytosol is an umlsterm, immunradiometrisch is an umlsterm, Tumoren is an umlsterm, Tumoren is an umlsterm, Karzinomgewebe is an umlsterm, Menopausenstatus is an umlsterm, Tumoren is an umlsterm, Oestrogen- is an umlsterm, Progesteronrezeptoren is an umlsterm, Tumoren is an umlsterm, Inzidenz is an umlsterm, steroidrezeptorpositiver is an umlsterm, Karzinome is an umlsterm, steroidrezeptornegativen is an umlsterm, Tumoren is an umlsterm

DerPathologe.50160278.ger.abstr_task0

Sentence: Die Synthese des pS 2-Proteins wird durch die oestrogenabhaengige Transkription des pS 2-Gens induziert . Dem Nachweis des pS 2-Proteins in Mammakarzinomen soll eine im Vergleich zum Rezeptorstatus gleichwertige oder hoehere Voraussagekraft hinsichtlich des Ansprechens auf eine hormonelle Therapie zukommen . Ebenso wird dem pS 2-Proteinnachweis eine prognostische Bedeutung zugesprochen . In 162 primaeren Mammakarzinomen wurde der pS 2-Nachweis an formalinfixierten und in Paraffin eingebetteten Gewebeschnitten durchgefuehrt und mittels eines immunreaktiven Score ( IRS ) semiquantitativ immunhistochemisch beurteilt . Die Konzentrationen des pS 2-Proteins im Zytosol wurde immunradiometrisch bestimmt . 27 % der Tumoren waren immunhistochemisch pS 2-positiv ( IRS > = 2 ) . Der Vergleich mit der biochemischen pS 2-Nachweismethode ( 26 % positive Tumoren bei einem Cut-off von 26 ng/mg Zytosolprotein ) erbrachte in 81 % eine konkordante qualitative Aussage des pS 2-Status ( r = 0,76 , p 0,0001 ) . Der immunhistochemische Nachweis von pS 2 im Karzinomgewebe korrelierte weder zum Alter oder Menopausenstatus der Patientinnen , noch zu Groesse oder Differenzierungsgrad der Tumoren oder zum Nodalstatus . Der immunhistochemische pS 2-Status korrelierte aber signifikant mit dem immunhistochemischen Nachweis der Oestrogen- ( ER , p 0,001 ) und Progesteronrezeptoren ( PR ; p 0,0001 ) . pS 2-positive Tumoren wiesen in 66 % einen positiven ER- und in 73 % einen positiven PR-Status auf bzw. waren in 89 % ER+ und/oder PR+. Die Inzidenz des immunhistochemischen pS 2-Nachweises lag in der Gruppe steroidrezeptorpositiver Karzinome ( ER und/oder PR positiv ) bei 41 % im Gegensatz zu 7 % bei steroidrezeptornegativen Tumoren ( ER und PR negativ ) . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Die Synthese des pS 2-Proteins wird durch die oestrogenabhaengige Transkription des pS 2-Gens induziert . Dem Nachweis des pS 2-Proteins in Mammakarzinomen soll eine im Vergleich zum Rezeptorstatus gleichwertige oder hoehere Voraussagekraft hinsichtlich des Ansprechens auf eine hormonelle Therapie zukommen . Ebenso wird dem pS 2-Proteinnachweis eine prognostische Bedeutung zugesprochen . In 162 primaeren Mammakarzinomen wurde der pS 2-Nachweis an formalinfixierten und in Paraffin eingebetteten Gewebeschnitten durchgefuehrt und mittels eines immunreaktiven Score ( IRS ) semiquantitativ immunhistochemisch beurteilt . Die Konzentrationen des pS 2-Proteins im Zytosol wurde immunradiometrisch bestimmt . 27 % der Tumoren waren immunhistochemisch pS 2-positiv ( IRS > = 2 ) . Der Vergleich mit der biochemischen pS 2-Nachweismethode ( 26 % positive Tumoren bei einem Cut-off von 26 ng/mg Zytosolprotein ) erbrachte in 81 % eine konkordante qualitative Aussage des pS 2-Status ( r = 0,76 , p 0,0001 ) . Der immunhistochemische Nachweis von pS 2 im Karzinomgewebe korrelierte weder zum Alter oder Menopausenstatus der Patientinnen , noch zu Groesse oder Differenzierungsgrad der Tumoren oder zum Nodalstatus . Der immunhistochemische pS 2-Status korrelierte aber signifikant mit dem immunhistochemischen Nachweis der Oestrogen- ( ER , p 0,001 ) und Progesteronrezeptoren ( PR ; p 0,0001 ) . pS 2-positive Tumoren wiesen in 66 % einen positiven ER- und in 73 % einen positiven PR-Status auf bzw. waren in 89 % ER+ und/oder PR+. Die Inzidenz des immunhistochemischen pS 2-Nachweises lag in der Gruppe steroidrezeptorpositiver Karzinome ( ER und/oder PR positiv ) bei 41 % im Gegensatz zu 7 % bei steroidrezeptornegativen Tumoren ( ER und PR negativ ) .

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[ "umlsterm" ]

oestrogenabhaengige is an umlsterm, Mammakarzinomen is an umlsterm, Therapie is an umlsterm, Mammakarzinomen is an umlsterm, formalinfixierten is an umlsterm, Paraffin is an umlsterm, Gewebeschnitten is an umlsterm, Konzentrationen is an umlsterm, Zytosol is an umlsterm, immunradiometrisch is an umlsterm, Tumoren is an umlsterm, Tumoren is an umlsterm, Karzinomgewebe is an umlsterm, Menopausenstatus is an umlsterm, Tumoren is an umlsterm, Oestrogen- is an umlsterm, Progesteronrezeptoren is an umlsterm, Tumoren is an umlsterm, Inzidenz is an umlsterm, steroidrezeptorpositiver is an umlsterm, Karzinome is an umlsterm, steroidrezeptornegativen is an umlsterm, Tumoren is an umlsterm

DerPathologe.50160278.ger.abstr_task1

Sentence: Die Synthese des pS 2-Proteins wird durch die oestrogenabhaengige Transkription des pS 2-Gens induziert . Dem Nachweis des pS 2-Proteins in Mammakarzinomen soll eine im Vergleich zum Rezeptorstatus gleichwertige oder hoehere Voraussagekraft hinsichtlich des Ansprechens auf eine hormonelle Therapie zukommen . Ebenso wird dem pS 2-Proteinnachweis eine prognostische Bedeutung zugesprochen . In 162 primaeren Mammakarzinomen wurde der pS 2-Nachweis an formalinfixierten und in Paraffin eingebetteten Gewebeschnitten durchgefuehrt und mittels eines immunreaktiven Score ( IRS ) semiquantitativ immunhistochemisch beurteilt . Die Konzentrationen des pS 2-Proteins im Zytosol wurde immunradiometrisch bestimmt . 27 % der Tumoren waren immunhistochemisch pS 2-positiv ( IRS > = 2 ) . Der Vergleich mit der biochemischen pS 2-Nachweismethode ( 26 % positive Tumoren bei einem Cut-off von 26 ng/mg Zytosolprotein ) erbrachte in 81 % eine konkordante qualitative Aussage des pS 2-Status ( r = 0,76 , p 0,0001 ) . Der immunhistochemische Nachweis von pS 2 im Karzinomgewebe korrelierte weder zum Alter oder Menopausenstatus der Patientinnen , noch zu Groesse oder Differenzierungsgrad der Tumoren oder zum Nodalstatus . Der immunhistochemische pS 2-Status korrelierte aber signifikant mit dem immunhistochemischen Nachweis der Oestrogen- ( ER , p 0,001 ) und Progesteronrezeptoren ( PR ; p 0,0001 ) . pS 2-positive Tumoren wiesen in 66 % einen positiven ER- und in 73 % einen positiven PR-Status auf bzw. waren in 89 % ER+ und/oder PR+. Die Inzidenz des immunhistochemischen pS 2-Nachweises lag in der Gruppe steroidrezeptorpositiver Karzinome ( ER und/oder PR positiv ) bei 41 % im Gegensatz zu 7 % bei steroidrezeptornegativen Tumoren ( ER und PR negativ ) . Instructions: please typing these entity words according to sentence: oestrogenabhaengige, Mammakarzinomen, Therapie, Mammakarzinomen, formalinfixierten, Paraffin, Gewebeschnitten, Konzentrationen, Zytosol, immunradiometrisch, Tumoren, Tumoren, Karzinomgewebe, Menopausenstatus, Tumoren, Oestrogen-, Progesteronrezeptoren, Tumoren, Inzidenz, steroidrezeptorpositiver, Karzinome, steroidrezeptornegativen, Tumoren Options: umlsterm

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Die Synthese des pS 2-Proteins wird durch die oestrogenabhaengige Transkription des pS 2-Gens induziert . Dem Nachweis des pS 2-Proteins in Mammakarzinomen soll eine im Vergleich zum Rezeptorstatus gleichwertige oder hoehere Voraussagekraft hinsichtlich des Ansprechens auf eine hormonelle Therapie zukommen . Ebenso wird dem pS 2-Proteinnachweis eine prognostische Bedeutung zugesprochen . In 162 primaeren Mammakarzinomen wurde der pS 2-Nachweis an formalinfixierten und in Paraffin eingebetteten Gewebeschnitten durchgefuehrt und mittels eines immunreaktiven Score ( IRS ) semiquantitativ immunhistochemisch beurteilt . Die Konzentrationen des pS 2-Proteins im Zytosol wurde immunradiometrisch bestimmt . 27 % der Tumoren waren immunhistochemisch pS 2-positiv ( IRS > = 2 ) . Der Vergleich mit der biochemischen pS 2-Nachweismethode ( 26 % positive Tumoren bei einem Cut-off von 26 ng/mg Zytosolprotein ) erbrachte in 81 % eine konkordante qualitative Aussage des pS 2-Status ( r = 0,76 , p 0,0001 ) . Der immunhistochemische Nachweis von pS 2 im Karzinomgewebe korrelierte weder zum Alter oder Menopausenstatus der Patientinnen , noch zu Groesse oder Differenzierungsgrad der Tumoren oder zum Nodalstatus . Der immunhistochemische pS 2-Status korrelierte aber signifikant mit dem immunhistochemischen Nachweis der Oestrogen- ( ER , p 0,001 ) und Progesteronrezeptoren ( PR ; p 0,0001 ) . pS 2-positive Tumoren wiesen in 66 % einen positiven ER- und in 73 % einen positiven PR-Status auf bzw. waren in 89 % ER+ und/oder PR+. Die Inzidenz des immunhistochemischen pS 2-Nachweises lag in der Gruppe steroidrezeptorpositiver Karzinome ( ER und/oder PR positiv ) bei 41 % im Gegensatz zu 7 % bei steroidrezeptornegativen Tumoren ( ER und PR negativ ) .

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[ "umlsterm" ]

oestrogenabhaengige, Mammakarzinomen, Therapie, Mammakarzinomen, formalinfixierten, Paraffin, Gewebeschnitten, Konzentrationen, Zytosol, immunradiometrisch, Tumoren, Tumoren, Karzinomgewebe, Menopausenstatus, Tumoren, Oestrogen-, Progesteronrezeptoren, Tumoren, Inzidenz, steroidrezeptorpositiver, Karzinome, steroidrezeptornegativen, Tumoren

DerPathologe.50160278.ger.abstr_task2

Sentence: Die Synthese des pS 2-Proteins wird durch die oestrogenabhaengige Transkription des pS 2-Gens induziert . Dem Nachweis des pS 2-Proteins in Mammakarzinomen soll eine im Vergleich zum Rezeptorstatus gleichwertige oder hoehere Voraussagekraft hinsichtlich des Ansprechens auf eine hormonelle Therapie zukommen . Ebenso wird dem pS 2-Proteinnachweis eine prognostische Bedeutung zugesprochen . In 162 primaeren Mammakarzinomen wurde der pS 2-Nachweis an formalinfixierten und in Paraffin eingebetteten Gewebeschnitten durchgefuehrt und mittels eines immunreaktiven Score ( IRS ) semiquantitativ immunhistochemisch beurteilt . Die Konzentrationen des pS 2-Proteins im Zytosol wurde immunradiometrisch bestimmt . 27 % der Tumoren waren immunhistochemisch pS 2-positiv ( IRS > = 2 ) . Der Vergleich mit der biochemischen pS 2-Nachweismethode ( 26 % positive Tumoren bei einem Cut-off von 26 ng/mg Zytosolprotein ) erbrachte in 81 % eine konkordante qualitative Aussage des pS 2-Status ( r = 0,76 , p 0,0001 ) . Der immunhistochemische Nachweis von pS 2 im Karzinomgewebe korrelierte weder zum Alter oder Menopausenstatus der Patientinnen , noch zu Groesse oder Differenzierungsgrad der Tumoren oder zum Nodalstatus . Der immunhistochemische pS 2-Status korrelierte aber signifikant mit dem immunhistochemischen Nachweis der Oestrogen- ( ER , p 0,001 ) und Progesteronrezeptoren ( PR ; p 0,0001 ) . pS 2-positive Tumoren wiesen in 66 % einen positiven ER- und in 73 % einen positiven PR-Status auf bzw. waren in 89 % ER+ und/oder PR+. Die Inzidenz des immunhistochemischen pS 2-Nachweises lag in der Gruppe steroidrezeptorpositiver Karzinome ( ER und/oder PR positiv ) bei 41 % im Gegensatz zu 7 % bei steroidrezeptornegativen Tumoren ( ER und PR negativ ) . Instructions: please extract entity words from the input sentence

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Die Synthese des pS 2-Proteins wird durch die oestrogenabhaengige Transkription des pS 2-Gens induziert . Dem Nachweis des pS 2-Proteins in Mammakarzinomen soll eine im Vergleich zum Rezeptorstatus gleichwertige oder hoehere Voraussagekraft hinsichtlich des Ansprechens auf eine hormonelle Therapie zukommen . Ebenso wird dem pS 2-Proteinnachweis eine prognostische Bedeutung zugesprochen . In 162 primaeren Mammakarzinomen wurde der pS 2-Nachweis an formalinfixierten und in Paraffin eingebetteten Gewebeschnitten durchgefuehrt und mittels eines immunreaktiven Score ( IRS ) semiquantitativ immunhistochemisch beurteilt . Die Konzentrationen des pS 2-Proteins im Zytosol wurde immunradiometrisch bestimmt . 27 % der Tumoren waren immunhistochemisch pS 2-positiv ( IRS > = 2 ) . Der Vergleich mit der biochemischen pS 2-Nachweismethode ( 26 % positive Tumoren bei einem Cut-off von 26 ng/mg Zytosolprotein ) erbrachte in 81 % eine konkordante qualitative Aussage des pS 2-Status ( r = 0,76 , p 0,0001 ) . Der immunhistochemische Nachweis von pS 2 im Karzinomgewebe korrelierte weder zum Alter oder Menopausenstatus der Patientinnen , noch zu Groesse oder Differenzierungsgrad der Tumoren oder zum Nodalstatus . Der immunhistochemische pS 2-Status korrelierte aber signifikant mit dem immunhistochemischen Nachweis der Oestrogen- ( ER , p 0,001 ) und Progesteronrezeptoren ( PR ; p 0,0001 ) . pS 2-positive Tumoren wiesen in 66 % einen positiven ER- und in 73 % einen positiven PR-Status auf bzw. waren in 89 % ER+ und/oder PR+. Die Inzidenz des immunhistochemischen pS 2-Nachweises lag in der Gruppe steroidrezeptorpositiver Karzinome ( ER und/oder PR positiv ) bei 41 % im Gegensatz zu 7 % bei steroidrezeptornegativen Tumoren ( ER und PR negativ ) .

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[ "umlsterm" ]

Tetraplegie is an umlsterm, Patientenauswahl is an umlsterm, Patienten is an umlsterm, supraventrikulaere Tachykardien is an umlsterm, Ventrikulaere Tachykardien is an umlsterm, Bradykardien is an umlsterm, Patient is an umlsterm, Blutdruckwerte is an umlsterm, Blutdruckabfaelle is an umlsterm, Afferente is an umlsterm, Konduktionsbloecke is an umlsterm, Afferente is an umlsterm, Katecholaminexzesse is an umlsterm, Tachykardie is an umlsterm, Hyperglykaemie is an umlsterm, Dehnungsrezeptoren is an umlsterm, Blutdrucklabilitaet is an umlsterm, Risikofaktoren is an umlsterm, Tetraplegie is an umlsterm, Propriozeption is an umlsterm, Blutdrucklabilitaet is an umlsterm, Patienten is an umlsterm

DerNervenarzt.90700136.ger.abstr_task0

Sentence: Bei GBS-Patienten mit Tetraplegie oder propriozeptiven Ausfaellen sind vegetative Stoerungen haeufig und nicht selten bedrohlich . Je nach verwendetem Grenzwert und abhaengig von der Patientenauswahl haben 20-75% der Patienten supraventrikulaere Tachykardien . Ventrikulaere Tachykardien sind seltener vital bedrohlich als Bradykardien , die spontan und nach verschiedenen thorakalen und orofazialen Reizen auftreten koennen . Etwa jeder fuenfte Patient ist dauerhafter hyperton . Typisch sind bizarr schwankende Blutdruckwerte . Seltener stehen Blutdruckabfaelle im Vordergrund . Afferente Konduktionsbloecke entzuegeln diverse Efferenzen . So kommt es bei Ausfall sinoatrialer Dehnungsafferenzen zur unangemessenen ADH- und Reninausschuettung . Afferente Stoerungen des Barorezeptorreflexes verursachen Katecholaminexzesse , die zu Hypertonus , Tachykardie , EKG-Veraenderungen und Hyperglykaemie fuehren . Ausserdem steigern sie die Empfindlichkeit unmyeliniserter linksventrikulaerer Dehnungsrezeptoren , die kardio- und vasodepressorisch wirken und zur Blutdrucklabilitaet beitragen . Intakt gebliebene unmyelinisierte Afferenzen vermitteln nicht selten bradykarde Reaktionen , v.a. wenn das Gegengewicht tachykard wirkender myelinisierter Afferenzen verloren gegangen ist . Ein Beispiel sind hochschwellige unmyelinisierte pulmonale Dehnungsafferenzen , die bei der Seufzerbeatmung stimuliert werden . Die Kenntnis der klinischen Risikofaktoren Tetraplegie und gestoerte Propriozeption , des wichtigsten Dysautonomieindikators Blutdrucklabilitaet und die Anwendung vegetativer Funktionstests helfen , bedrohte Patienten zu erkennen , die kardial ueberwacht werden muessen . Angesichts der haeufigen afferenten Fehlmeldungen ist eine sympathische und parasympathische Blockade unter Schrittmacherbereitschaft zu erwaegen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Bei GBS-Patienten mit Tetraplegie oder propriozeptiven Ausfaellen sind vegetative Stoerungen haeufig und nicht selten bedrohlich . Je nach verwendetem Grenzwert und abhaengig von der Patientenauswahl haben 20-75% der Patienten supraventrikulaere Tachykardien . Ventrikulaere Tachykardien sind seltener vital bedrohlich als Bradykardien , die spontan und nach verschiedenen thorakalen und orofazialen Reizen auftreten koennen . Etwa jeder fuenfte Patient ist dauerhafter hyperton . Typisch sind bizarr schwankende Blutdruckwerte . Seltener stehen Blutdruckabfaelle im Vordergrund . Afferente Konduktionsbloecke entzuegeln diverse Efferenzen . So kommt es bei Ausfall sinoatrialer Dehnungsafferenzen zur unangemessenen ADH- und Reninausschuettung . Afferente Stoerungen des Barorezeptorreflexes verursachen Katecholaminexzesse , die zu Hypertonus , Tachykardie , EKG-Veraenderungen und Hyperglykaemie fuehren . Ausserdem steigern sie die Empfindlichkeit unmyeliniserter linksventrikulaerer Dehnungsrezeptoren , die kardio- und vasodepressorisch wirken und zur Blutdrucklabilitaet beitragen . Intakt gebliebene unmyelinisierte Afferenzen vermitteln nicht selten bradykarde Reaktionen , v.a. wenn das Gegengewicht tachykard wirkender myelinisierter Afferenzen verloren gegangen ist . Ein Beispiel sind hochschwellige unmyelinisierte pulmonale Dehnungsafferenzen , die bei der Seufzerbeatmung stimuliert werden . Die Kenntnis der klinischen Risikofaktoren Tetraplegie und gestoerte Propriozeption , des wichtigsten Dysautonomieindikators Blutdrucklabilitaet und die Anwendung vegetativer Funktionstests helfen , bedrohte Patienten zu erkennen , die kardial ueberwacht werden muessen . Angesichts der haeufigen afferenten Fehlmeldungen ist eine sympathische und parasympathische Blockade unter Schrittmacherbereitschaft zu erwaegen .

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[ "umlsterm" ]

Tetraplegie is an umlsterm, Patientenauswahl is an umlsterm, Patienten is an umlsterm, supraventrikulaere Tachykardien is an umlsterm, Ventrikulaere Tachykardien is an umlsterm, Bradykardien is an umlsterm, Patient is an umlsterm, Blutdruckwerte is an umlsterm, Blutdruckabfaelle is an umlsterm, Afferente is an umlsterm, Konduktionsbloecke is an umlsterm, Afferente is an umlsterm, Katecholaminexzesse is an umlsterm, Tachykardie is an umlsterm, Hyperglykaemie is an umlsterm, Dehnungsrezeptoren is an umlsterm, Blutdrucklabilitaet is an umlsterm, Risikofaktoren is an umlsterm, Tetraplegie is an umlsterm, Propriozeption is an umlsterm, Blutdrucklabilitaet is an umlsterm, Patienten is an umlsterm

DerNervenarzt.90700136.ger.abstr_task1

Sentence: Bei GBS-Patienten mit Tetraplegie oder propriozeptiven Ausfaellen sind vegetative Stoerungen haeufig und nicht selten bedrohlich . Je nach verwendetem Grenzwert und abhaengig von der Patientenauswahl haben 20-75% der Patienten supraventrikulaere Tachykardien . Ventrikulaere Tachykardien sind seltener vital bedrohlich als Bradykardien , die spontan und nach verschiedenen thorakalen und orofazialen Reizen auftreten koennen . Etwa jeder fuenfte Patient ist dauerhafter hyperton . Typisch sind bizarr schwankende Blutdruckwerte . Seltener stehen Blutdruckabfaelle im Vordergrund . Afferente Konduktionsbloecke entzuegeln diverse Efferenzen . So kommt es bei Ausfall sinoatrialer Dehnungsafferenzen zur unangemessenen ADH- und Reninausschuettung . Afferente Stoerungen des Barorezeptorreflexes verursachen Katecholaminexzesse , die zu Hypertonus , Tachykardie , EKG-Veraenderungen und Hyperglykaemie fuehren . Ausserdem steigern sie die Empfindlichkeit unmyeliniserter linksventrikulaerer Dehnungsrezeptoren , die kardio- und vasodepressorisch wirken und zur Blutdrucklabilitaet beitragen . Intakt gebliebene unmyelinisierte Afferenzen vermitteln nicht selten bradykarde Reaktionen , v.a. wenn das Gegengewicht tachykard wirkender myelinisierter Afferenzen verloren gegangen ist . Ein Beispiel sind hochschwellige unmyelinisierte pulmonale Dehnungsafferenzen , die bei der Seufzerbeatmung stimuliert werden . Die Kenntnis der klinischen Risikofaktoren Tetraplegie und gestoerte Propriozeption , des wichtigsten Dysautonomieindikators Blutdrucklabilitaet und die Anwendung vegetativer Funktionstests helfen , bedrohte Patienten zu erkennen , die kardial ueberwacht werden muessen . Angesichts der haeufigen afferenten Fehlmeldungen ist eine sympathische und parasympathische Blockade unter Schrittmacherbereitschaft zu erwaegen . Instructions: please typing these entity words according to sentence: Tetraplegie, Patientenauswahl, Patienten, supraventrikulaere Tachykardien, Ventrikulaere Tachykardien, Bradykardien, Patient, Blutdruckwerte, Blutdruckabfaelle, Afferente, Konduktionsbloecke, Afferente, Katecholaminexzesse, Tachykardie, Hyperglykaemie, Dehnungsrezeptoren, Blutdrucklabilitaet, Risikofaktoren, Tetraplegie, Propriozeption, Blutdrucklabilitaet, Patienten Options: umlsterm

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Bei GBS-Patienten mit Tetraplegie oder propriozeptiven Ausfaellen sind vegetative Stoerungen haeufig und nicht selten bedrohlich . Je nach verwendetem Grenzwert und abhaengig von der Patientenauswahl haben 20-75% der Patienten supraventrikulaere Tachykardien . Ventrikulaere Tachykardien sind seltener vital bedrohlich als Bradykardien , die spontan und nach verschiedenen thorakalen und orofazialen Reizen auftreten koennen . Etwa jeder fuenfte Patient ist dauerhafter hyperton . Typisch sind bizarr schwankende Blutdruckwerte . Seltener stehen Blutdruckabfaelle im Vordergrund . Afferente Konduktionsbloecke entzuegeln diverse Efferenzen . So kommt es bei Ausfall sinoatrialer Dehnungsafferenzen zur unangemessenen ADH- und Reninausschuettung . Afferente Stoerungen des Barorezeptorreflexes verursachen Katecholaminexzesse , die zu Hypertonus , Tachykardie , EKG-Veraenderungen und Hyperglykaemie fuehren . Ausserdem steigern sie die Empfindlichkeit unmyeliniserter linksventrikulaerer Dehnungsrezeptoren , die kardio- und vasodepressorisch wirken und zur Blutdrucklabilitaet beitragen . Intakt gebliebene unmyelinisierte Afferenzen vermitteln nicht selten bradykarde Reaktionen , v.a. wenn das Gegengewicht tachykard wirkender myelinisierter Afferenzen verloren gegangen ist . Ein Beispiel sind hochschwellige unmyelinisierte pulmonale Dehnungsafferenzen , die bei der Seufzerbeatmung stimuliert werden . Die Kenntnis der klinischen Risikofaktoren Tetraplegie und gestoerte Propriozeption , des wichtigsten Dysautonomieindikators Blutdrucklabilitaet und die Anwendung vegetativer Funktionstests helfen , bedrohte Patienten zu erkennen , die kardial ueberwacht werden muessen . Angesichts der haeufigen afferenten Fehlmeldungen ist eine sympathische und parasympathische Blockade unter Schrittmacherbereitschaft zu erwaegen .

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[ "umlsterm" ]

Tetraplegie, Patientenauswahl, Patienten, supraventrikulaere Tachykardien, Ventrikulaere Tachykardien, Bradykardien, Patient, Blutdruckwerte, Blutdruckabfaelle, Afferente, Konduktionsbloecke, Afferente, Katecholaminexzesse, Tachykardie, Hyperglykaemie, Dehnungsrezeptoren, Blutdrucklabilitaet, Risikofaktoren, Tetraplegie, Propriozeption, Blutdrucklabilitaet, Patienten

DerNervenarzt.90700136.ger.abstr_task2

Sentence: Bei GBS-Patienten mit Tetraplegie oder propriozeptiven Ausfaellen sind vegetative Stoerungen haeufig und nicht selten bedrohlich . Je nach verwendetem Grenzwert und abhaengig von der Patientenauswahl haben 20-75% der Patienten supraventrikulaere Tachykardien . Ventrikulaere Tachykardien sind seltener vital bedrohlich als Bradykardien , die spontan und nach verschiedenen thorakalen und orofazialen Reizen auftreten koennen . Etwa jeder fuenfte Patient ist dauerhafter hyperton . Typisch sind bizarr schwankende Blutdruckwerte . Seltener stehen Blutdruckabfaelle im Vordergrund . Afferente Konduktionsbloecke entzuegeln diverse Efferenzen . So kommt es bei Ausfall sinoatrialer Dehnungsafferenzen zur unangemessenen ADH- und Reninausschuettung . Afferente Stoerungen des Barorezeptorreflexes verursachen Katecholaminexzesse , die zu Hypertonus , Tachykardie , EKG-Veraenderungen und Hyperglykaemie fuehren . Ausserdem steigern sie die Empfindlichkeit unmyeliniserter linksventrikulaerer Dehnungsrezeptoren , die kardio- und vasodepressorisch wirken und zur Blutdrucklabilitaet beitragen . Intakt gebliebene unmyelinisierte Afferenzen vermitteln nicht selten bradykarde Reaktionen , v.a. wenn das Gegengewicht tachykard wirkender myelinisierter Afferenzen verloren gegangen ist . Ein Beispiel sind hochschwellige unmyelinisierte pulmonale Dehnungsafferenzen , die bei der Seufzerbeatmung stimuliert werden . Die Kenntnis der klinischen Risikofaktoren Tetraplegie und gestoerte Propriozeption , des wichtigsten Dysautonomieindikators Blutdrucklabilitaet und die Anwendung vegetativer Funktionstests helfen , bedrohte Patienten zu erkennen , die kardial ueberwacht werden muessen . Angesichts der haeufigen afferenten Fehlmeldungen ist eine sympathische und parasympathische Blockade unter Schrittmacherbereitschaft zu erwaegen . Instructions: please extract entity words from the input sentence

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Bei GBS-Patienten mit Tetraplegie oder propriozeptiven Ausfaellen sind vegetative Stoerungen haeufig und nicht selten bedrohlich . Je nach verwendetem Grenzwert und abhaengig von der Patientenauswahl haben 20-75% der Patienten supraventrikulaere Tachykardien . Ventrikulaere Tachykardien sind seltener vital bedrohlich als Bradykardien , die spontan und nach verschiedenen thorakalen und orofazialen Reizen auftreten koennen . Etwa jeder fuenfte Patient ist dauerhafter hyperton . Typisch sind bizarr schwankende Blutdruckwerte . Seltener stehen Blutdruckabfaelle im Vordergrund . Afferente Konduktionsbloecke entzuegeln diverse Efferenzen . So kommt es bei Ausfall sinoatrialer Dehnungsafferenzen zur unangemessenen ADH- und Reninausschuettung . Afferente Stoerungen des Barorezeptorreflexes verursachen Katecholaminexzesse , die zu Hypertonus , Tachykardie , EKG-Veraenderungen und Hyperglykaemie fuehren . Ausserdem steigern sie die Empfindlichkeit unmyeliniserter linksventrikulaerer Dehnungsrezeptoren , die kardio- und vasodepressorisch wirken und zur Blutdrucklabilitaet beitragen . Intakt gebliebene unmyelinisierte Afferenzen vermitteln nicht selten bradykarde Reaktionen , v.a. wenn das Gegengewicht tachykard wirkender myelinisierter Afferenzen verloren gegangen ist . Ein Beispiel sind hochschwellige unmyelinisierte pulmonale Dehnungsafferenzen , die bei der Seufzerbeatmung stimuliert werden . Die Kenntnis der klinischen Risikofaktoren Tetraplegie und gestoerte Propriozeption , des wichtigsten Dysautonomieindikators Blutdrucklabilitaet und die Anwendung vegetativer Funktionstests helfen , bedrohte Patienten zu erkennen , die kardial ueberwacht werden muessen . Angesichts der haeufigen afferenten Fehlmeldungen ist eine sympathische und parasympathische Blockade unter Schrittmacherbereitschaft zu erwaegen .

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[ "umlsterm" ]

USF is a protein-family, DOR promoter is a DNA, Sp1 is a protein, Sp3 is a protein, NS20Y is a cell

1.0alpha7.train.474_task0

Sentence: Thus, binding of USF to the DOR promoter sequence is more critical than that of Sp1/Sp3 in NS20Y cells. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: DNA, cell, protein-family, protein

[ "O", "O", "O", "O", "O", "O", "B-protein-family", "O", "O", "O", "B-DNA", "I-DNA", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "B-protein", "O", "O", "B-cell", "O", "O", "O" ]

Thus, binding of USF to the DOR promoter sequence is more critical than that of Sp1/Sp3 in NS20Y cells.

[ " ", "Thus", ",", "binding", "of", " ", "USF", "to", "the", " ", "DOR", "promoter", "sequence", "is", "more", "critical", "than", "that", "of", " ", "Sp1", "/", "Sp3", "in", " ", "NS20Y", "cells", ".", " " ]

[ "DNA", "cell", "protein-family", "protein" ]

USF is a protein-family, DOR promoter is a DNA, Sp1 is a protein, Sp3 is a protein, NS20Y is a cell

1.0alpha7.train.474_task1

Sentence: Thus, binding of USF to the DOR promoter sequence is more critical than that of Sp1/Sp3 in NS20Y cells. Instructions: please typing these entity words according to sentence: USF, DOR promoter, Sp1, Sp3, NS20Y Options: DNA, cell, protein-family, protein

[ "O", "O", "O", "O", "O", "O", "B-protein-family", "O", "O", "O", "B-DNA", "I-DNA", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "B-protein", "O", "O", "B-cell", "O", "O", "O" ]

Thus, binding of USF to the DOR promoter sequence is more critical than that of Sp1/Sp3 in NS20Y cells.

[ " ", "Thus", ",", "binding", "of", " ", "USF", "to", "the", " ", "DOR", "promoter", "sequence", "is", "more", "critical", "than", "that", "of", " ", "Sp1", "/", "Sp3", "in", " ", "NS20Y", "cells", ".", " " ]

[ "DNA", "cell", "protein-family", "protein" ]

USF, DOR promoter, Sp1, Sp3, NS20Y

1.0alpha7.train.474_task2

Sentence: Thus, binding of USF to the DOR promoter sequence is more critical than that of Sp1/Sp3 in NS20Y cells. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "B-protein-family", "O", "O", "O", "B-DNA", "I-DNA", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "B-protein", "O", "O", "B-cell", "O", "O", "O" ]

Thus, binding of USF to the DOR promoter sequence is more critical than that of Sp1/Sp3 in NS20Y cells.

[ " ", "Thus", ",", "binding", "of", " ", "USF", "to", "the", " ", "DOR", "promoter", "sequence", "is", "more", "critical", "than", "that", "of", " ", "Sp1", "/", "Sp3", "in", " ", "NS20Y", "cells", ".", " " ]

[ "DNA", "cell", "protein-family", "protein" ]

Dermatologic disorders is an umlsterm, stump is an umlsterm, patients is an umlsterm, leg is an umlsterm, amputation is an umlsterm, knowledge is an umlsterm, diagnosis is an umlsterm, immobilization is an umlsterm, language is an umlsterm, review is an umlsterm, dermatology is an umlsterm, prostheses is an umlsterm, blisters is an umlsterm, keratoses is an umlsterm, epidermoid cysts is an umlsterm, stump is an umlsterm, edema is an umlsterm, syndrome is an umlsterm, sarcoma is an umlsterm, hyperplasia is an umlsterm

DerHautarzt.60470493.eng.abstr_task0

Sentence: Dermatologic disorders of the stump in patients with a leg amputation may have characteristic pathophysiologic and clinical features . A knowledge of these factors may lead to earlier diagnosis and avoid immobilization . There ist no German language review of this aspect of dermatology . After providing an overview of the problem , including a discussion of prostheses , we review the following problems : mechanically induced blisters , follicular keratoses , epidermoid cysts , stump edema syndrome , acroangiodermatitis ( pseudo-kaposi sarcoma ) and verrucous hyperplasia . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O" ]

Dermatologic disorders of the stump in patients with a leg amputation may have characteristic pathophysiologic and clinical features . A knowledge of these factors may lead to earlier diagnosis and avoid immobilization . There ist no German language review of this aspect of dermatology . After providing an overview of the problem , including a discussion of prostheses , we review the following problems : mechanically induced blisters , follicular keratoses , epidermoid cysts , stump edema syndrome , acroangiodermatitis ( pseudo-kaposi sarcoma ) and verrucous hyperplasia .

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[ "umlsterm" ]

Dermatologic disorders is an umlsterm, stump is an umlsterm, patients is an umlsterm, leg is an umlsterm, amputation is an umlsterm, knowledge is an umlsterm, diagnosis is an umlsterm, immobilization is an umlsterm, language is an umlsterm, review is an umlsterm, dermatology is an umlsterm, prostheses is an umlsterm, blisters is an umlsterm, keratoses is an umlsterm, epidermoid cysts is an umlsterm, stump is an umlsterm, edema is an umlsterm, syndrome is an umlsterm, sarcoma is an umlsterm, hyperplasia is an umlsterm

DerHautarzt.60470493.eng.abstr_task1

Sentence: Dermatologic disorders of the stump in patients with a leg amputation may have characteristic pathophysiologic and clinical features . A knowledge of these factors may lead to earlier diagnosis and avoid immobilization . There ist no German language review of this aspect of dermatology . After providing an overview of the problem , including a discussion of prostheses , we review the following problems : mechanically induced blisters , follicular keratoses , epidermoid cysts , stump edema syndrome , acroangiodermatitis ( pseudo-kaposi sarcoma ) and verrucous hyperplasia . Instructions: please typing these entity words according to sentence: Dermatologic disorders, stump, patients, leg, amputation, knowledge, diagnosis, immobilization, language, review, dermatology, prostheses, blisters, keratoses, epidermoid cysts, stump, edema, syndrome, sarcoma, hyperplasia Options: umlsterm

[ "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O" ]

Dermatologic disorders of the stump in patients with a leg amputation may have characteristic pathophysiologic and clinical features . A knowledge of these factors may lead to earlier diagnosis and avoid immobilization . There ist no German language review of this aspect of dermatology . After providing an overview of the problem , including a discussion of prostheses , we review the following problems : mechanically induced blisters , follicular keratoses , epidermoid cysts , stump edema syndrome , acroangiodermatitis ( pseudo-kaposi sarcoma ) and verrucous hyperplasia .

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[ "umlsterm" ]

Dermatologic disorders, stump, patients, leg, amputation, knowledge, diagnosis, immobilization, language, review, dermatology, prostheses, blisters, keratoses, epidermoid cysts, stump, edema, syndrome, sarcoma, hyperplasia

DerHautarzt.60470493.eng.abstr_task2

Sentence: Dermatologic disorders of the stump in patients with a leg amputation may have characteristic pathophysiologic and clinical features . A knowledge of these factors may lead to earlier diagnosis and avoid immobilization . There ist no German language review of this aspect of dermatology . After providing an overview of the problem , including a discussion of prostheses , we review the following problems : mechanically induced blisters , follicular keratoses , epidermoid cysts , stump edema syndrome , acroangiodermatitis ( pseudo-kaposi sarcoma ) and verrucous hyperplasia . Instructions: please extract entity words from the input sentence

[ "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O" ]

Dermatologic disorders of the stump in patients with a leg amputation may have characteristic pathophysiologic and clinical features . A knowledge of these factors may lead to earlier diagnosis and avoid immobilization . There ist no German language review of this aspect of dermatology . After providing an overview of the problem , including a discussion of prostheses , we review the following problems : mechanically induced blisters , follicular keratoses , epidermoid cysts , stump edema syndrome , acroangiodermatitis ( pseudo-kaposi sarcoma ) and verrucous hyperplasia .

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[ "umlsterm" ]

5-benzylidene thiazolidine-2,4-dione is a CHEMICAL

23537942_task0

Sentence: Anticancer activity of novel hybrid molecules containing 5-benzylidene thiazolidine-2,4-dione. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL

[ "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O" ]

Anticancer activity of novel hybrid molecules containing 5-benzylidene thiazolidine-2,4-dione.

[ "Anticancer", "activity", "of", "novel", "hybrid", "molecules", "containing", "5-benzylidene", "thiazolidine-2,4-dione", "." ]

[ "CHEMICAL", "GENE-Y", "GENE-N" ]

5-benzylidene thiazolidine-2,4-dione is a CHEMICAL

23537942_task1

Sentence: Anticancer activity of novel hybrid molecules containing 5-benzylidene thiazolidine-2,4-dione. Instructions: please typing these entity words according to sentence: 5-benzylidene thiazolidine-2,4-dione Options: CHEMICAL

[ "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O" ]

Anticancer activity of novel hybrid molecules containing 5-benzylidene thiazolidine-2,4-dione.

[ "Anticancer", "activity", "of", "novel", "hybrid", "molecules", "containing", "5-benzylidene", "thiazolidine-2,4-dione", "." ]

[ "CHEMICAL", "GENE-Y", "GENE-N" ]

5-benzylidene thiazolidine-2,4-dione

23537942_task2

Sentence: Anticancer activity of novel hybrid molecules containing 5-benzylidene thiazolidine-2,4-dione. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O" ]

Anticancer activity of novel hybrid molecules containing 5-benzylidene thiazolidine-2,4-dione.

[ "Anticancer", "activity", "of", "novel", "hybrid", "molecules", "containing", "5-benzylidene", "thiazolidine-2,4-dione", "." ]

[ "CHEMICAL", "GENE-Y", "GENE-N" ]

inosine-5'-monophosphate dehydrogenase type II is a protein_molecule, human T cells is a cell_type, 5 ' palindromic octamer sequence is a DNA_domain_or_region

58976_task0

Sentence: Regulation of inosine-5'-monophosphate dehydrogenase type II gene expression in human T cells. Role for a novel 5' palindromic octamer sequence. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: cell_type, DNA_domain_or_region, protein_molecule

[ "O", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "O", "B-cell_type", "I-cell_type", "I-cell_type", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O" ]

Regulation of inosine-5'-monophosphate dehydrogenase type II gene expression in human T cells. Role for a novel 5' palindromic octamer sequence.

[ "Regulation", "of", "inosine-5'-monophosphate", "dehydrogenase", "type", "II", "gene", "expression", "in", "human", "T", "cells", ".", "Role", "for", "a", "novel", "5", "'", "palindromic", "octamer", "sequence", "." ]

[ "protein_molecule", "cell_type", "other_name", "DNA_domain_or_region", "protein_family_or_group", "nucleotide", "(AND DNA_domain_or_region DNA_domain_or_region)", "DNA_family_or_group", "" ]

inosine-5'-monophosphate dehydrogenase type II is a protein_molecule, human T cells is a cell_type, 5 ' palindromic octamer sequence is a DNA_domain_or_region

58976_task1

Sentence: Regulation of inosine-5'-monophosphate dehydrogenase type II gene expression in human T cells. Role for a novel 5' palindromic octamer sequence. Instructions: please typing these entity words according to sentence: inosine-5'-monophosphate dehydrogenase type II, human T cells, 5 ' palindromic octamer sequence Options: cell_type, DNA_domain_or_region, protein_molecule

[ "O", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "O", "B-cell_type", "I-cell_type", "I-cell_type", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O" ]

Regulation of inosine-5'-monophosphate dehydrogenase type II gene expression in human T cells. Role for a novel 5' palindromic octamer sequence.

[ "Regulation", "of", "inosine-5'-monophosphate", "dehydrogenase", "type", "II", "gene", "expression", "in", "human", "T", "cells", ".", "Role", "for", "a", "novel", "5", "'", "palindromic", "octamer", "sequence", "." ]

[ "protein_molecule", "cell_type", "other_name", "DNA_domain_or_region", "protein_family_or_group", "nucleotide", "(AND DNA_domain_or_region DNA_domain_or_region)", "DNA_family_or_group", "" ]

inosine-5'-monophosphate dehydrogenase type II, human T cells, 5 ' palindromic octamer sequence

58976_task2

Sentence: Regulation of inosine-5'-monophosphate dehydrogenase type II gene expression in human T cells. Role for a novel 5' palindromic octamer sequence. Instructions: please extract entity words from the input sentence

[ "O", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "O", "B-cell_type", "I-cell_type", "I-cell_type", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O" ]

Regulation of inosine-5'-monophosphate dehydrogenase type II gene expression in human T cells. Role for a novel 5' palindromic octamer sequence.

[ "Regulation", "of", "inosine-5'-monophosphate", "dehydrogenase", "type", "II", "gene", "expression", "in", "human", "T", "cells", ".", "Role", "for", "a", "novel", "5", "'", "palindromic", "octamer", "sequence", "." ]

[ "protein_molecule", "cell_type", "other_name", "DNA_domain_or_region", "protein_family_or_group", "nucleotide", "(AND DNA_domain_or_region DNA_domain_or_region)", "DNA_family_or_group", "" ]

Clinical/ Histological/ cytological/ Imaging examination is a Scope, Oral / Oropharynx is a Scope, Squamous - cell carcinoma is a Condition, Tongue , buccal mucosa , mouth floor , hard palate , Molar area is a Scope, depth of invasion is a Measurement, > 4 mm is a Value, preoperative assessment is a Procedure, clinical stage I / II is a Scope, T1 - 2 N0 M0 is a Scope, surgical resection is a Procedure, Normal is a Value, bone marrow reserve function is a Measurement, normal is a Value, kidney function is a Measurement

NCT03017053_inc_task0

Sentence: Ability to understand and the willingness to sign a written informed consent document Age= 18 and= 75 years Clinical/ Histological/ cytological/ Imaging examination proven Oral/Oropharynx Squamous-cell carcinoma (Tongue, buccal mucosa, mouth floor, hard palate, Molar area), the depth of invasion > 4mm in preoperative assessment In line with clinical stage I / II stage (T1-2 N0 M0; AJCC 2010) and receiving surgical resection KPS= 70 Normal bone marrow reserve function and normal liver, kidney function Expected survival period= 6 months Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Condition, Value, Procedure, Scope, Measurement

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Scope", "I-Scope", "I-Scope", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "B-Procedure", "I-Procedure", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "O", "O", "B-Value", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "O", "B-Value", "O", "O", "B-Measurement", "I-Measurement", "O", "O", "O", "O", "O", "O", "O" ]

Ability to understand and the willingness to sign a written informed consent document Age= 18 and= 75 years Clinical/ Histological/ cytological/ Imaging examination proven Oral/Oropharynx Squamous-cell carcinoma (Tongue, buccal mucosa, mouth floor, hard palate, Molar area), the depth of invasion > 4mm in preoperative assessment In line with clinical stage I / II stage (T1-2 N0 M0; AJCC 2010) and receiving surgical resection KPS= 70 Normal bone marrow reserve function and normal liver, kidney function Expected survival period= 6 months

[ "Ability", "to", "understand", "and", "the", "willingness", "to", "sign", "a", "written", "informed", "consent", "document", "\n", "Age=", "18", "and=", "75", "years", "\n", "Clinical/", "Histological/", "cytological/", "Imaging", "examination", "proven", "Oral", "/", "Oropharynx", "Squamous", "-", "cell", "carcinoma", "(", "Tongue", ",", "buccal", "mucosa", ",", "mouth", "floor", ",", "hard", "palate", ",", "Molar", "area", ")", ",", "the", "depth", "of", "invasion", ">", "4", "mm", "in", "preoperative", "assessment", "\n", "In", "line", "with", "clinical", "stage", "I", "/", "II", "stage", "(", "T1", "-", "2", "N0", "M0", ";", "AJCC", "2010", ")", "and", "receiving", "surgical", "resection", "\n", "KPS=", "70", "\n", "Normal", "bone", "marrow", "reserve", "function", "and", "normal", "liver", ",", "kidney", "function", "\n", "Expected", "survival", "period=", "6", "months", "\n" ]

[ "Scope", "Measurement", "Observation", "Condition", "Procedure", "Value", "Qualifier", "Person" ]

Clinical/ Histological/ cytological/ Imaging examination is a Scope, Oral / Oropharynx is a Scope, Squamous - cell carcinoma is a Condition, Tongue , buccal mucosa , mouth floor , hard palate , Molar area is a Scope, depth of invasion is a Measurement, > 4 mm is a Value, preoperative assessment is a Procedure, clinical stage I / II is a Scope, T1 - 2 N0 M0 is a Scope, surgical resection is a Procedure, Normal is a Value, bone marrow reserve function is a Measurement, normal is a Value, kidney function is a Measurement

NCT03017053_inc_task1

Sentence: Ability to understand and the willingness to sign a written informed consent document Age= 18 and= 75 years Clinical/ Histological/ cytological/ Imaging examination proven Oral/Oropharynx Squamous-cell carcinoma (Tongue, buccal mucosa, mouth floor, hard palate, Molar area), the depth of invasion > 4mm in preoperative assessment In line with clinical stage I / II stage (T1-2 N0 M0; AJCC 2010) and receiving surgical resection KPS= 70 Normal bone marrow reserve function and normal liver, kidney function Expected survival period= 6 months Instructions: please typing these entity words according to sentence: Clinical/ Histological/ cytological/ Imaging examination, Oral / Oropharynx, Squamous - cell carcinoma, Tongue , buccal mucosa , mouth floor , hard palate , Molar area, depth of invasion, > 4 mm, preoperative assessment, clinical stage I / II, T1 - 2 N0 M0, surgical resection, Normal, bone marrow reserve function, normal, kidney function Options: Condition, Value, Procedure, Scope, Measurement

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Scope", "I-Scope", "I-Scope", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "B-Procedure", "I-Procedure", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "O", "O", "B-Value", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "O", "B-Value", "O", "O", "B-Measurement", "I-Measurement", "O", "O", "O", "O", "O", "O", "O" ]

Ability to understand and the willingness to sign a written informed consent document Age= 18 and= 75 years Clinical/ Histological/ cytological/ Imaging examination proven Oral/Oropharynx Squamous-cell carcinoma (Tongue, buccal mucosa, mouth floor, hard palate, Molar area), the depth of invasion > 4mm in preoperative assessment In line with clinical stage I / II stage (T1-2 N0 M0; AJCC 2010) and receiving surgical resection KPS= 70 Normal bone marrow reserve function and normal liver, kidney function Expected survival period= 6 months

[ "Ability", "to", "understand", "and", "the", "willingness", "to", "sign", "a", "written", "informed", "consent", "document", "\n", "Age=", "18", "and=", "75", "years", "\n", "Clinical/", "Histological/", "cytological/", "Imaging", "examination", "proven", "Oral", "/", "Oropharynx", "Squamous", "-", "cell", "carcinoma", "(", "Tongue", ",", "buccal", "mucosa", ",", "mouth", "floor", ",", "hard", "palate", ",", "Molar", "area", ")", ",", "the", "depth", "of", "invasion", ">", "4", "mm", "in", "preoperative", "assessment", "\n", "In", "line", "with", "clinical", "stage", "I", "/", "II", "stage", "(", "T1", "-", "2", "N0", "M0", ";", "AJCC", "2010", ")", "and", "receiving", "surgical", "resection", "\n", "KPS=", "70", "\n", "Normal", "bone", "marrow", "reserve", "function", "and", "normal", "liver", ",", "kidney", "function", "\n", "Expected", "survival", "period=", "6", "months", "\n" ]

[ "Scope", "Measurement", "Observation", "Condition", "Procedure", "Value", "Qualifier", "Person" ]

Clinical/ Histological/ cytological/ Imaging examination, Oral / Oropharynx, Squamous - cell carcinoma, Tongue , buccal mucosa , mouth floor , hard palate , Molar area, depth of invasion, > 4 mm, preoperative assessment, clinical stage I / II, T1 - 2 N0 M0, surgical resection, Normal, bone marrow reserve function, normal, kidney function

NCT03017053_inc_task2

Sentence: Ability to understand and the willingness to sign a written informed consent document Age= 18 and= 75 years Clinical/ Histological/ cytological/ Imaging examination proven Oral/Oropharynx Squamous-cell carcinoma (Tongue, buccal mucosa, mouth floor, hard palate, Molar area), the depth of invasion > 4mm in preoperative assessment In line with clinical stage I / II stage (T1-2 N0 M0; AJCC 2010) and receiving surgical resection KPS= 70 Normal bone marrow reserve function and normal liver, kidney function Expected survival period= 6 months Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Scope", "I-Scope", "I-Scope", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "B-Measurement", "I-Measurement", "I-Measurement", "B-Value", "I-Value", "I-Value", "O", "B-Procedure", "I-Procedure", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "O", "O", "O", "O", "B-Value", "B-Measurement", "I-Measurement", "I-Measurement", "I-Measurement", "O", "B-Value", "O", "O", "B-Measurement", "I-Measurement", "O", "O", "O", "O", "O", "O", "O" ]

Ability to understand and the willingness to sign a written informed consent document Age= 18 and= 75 years Clinical/ Histological/ cytological/ Imaging examination proven Oral/Oropharynx Squamous-cell carcinoma (Tongue, buccal mucosa, mouth floor, hard palate, Molar area), the depth of invasion > 4mm in preoperative assessment In line with clinical stage I / II stage (T1-2 N0 M0; AJCC 2010) and receiving surgical resection KPS= 70 Normal bone marrow reserve function and normal liver, kidney function Expected survival period= 6 months

[ "Ability", "to", "understand", "and", "the", "willingness", "to", "sign", "a", "written", "informed", "consent", "document", "\n", "Age=", "18", "and=", "75", "years", "\n", "Clinical/", "Histological/", "cytological/", "Imaging", "examination", "proven", "Oral", "/", "Oropharynx", "Squamous", "-", "cell", "carcinoma", "(", "Tongue", ",", "buccal", "mucosa", ",", "mouth", "floor", ",", "hard", "palate", ",", "Molar", "area", ")", ",", "the", "depth", "of", "invasion", ">", "4", "mm", "in", "preoperative", "assessment", "\n", "In", "line", "with", "clinical", "stage", "I", "/", "II", "stage", "(", "T1", "-", "2", "N0", "M0", ";", "AJCC", "2010", ")", "and", "receiving", "surgical", "resection", "\n", "KPS=", "70", "\n", "Normal", "bone", "marrow", "reserve", "function", "and", "normal", "liver", ",", "kidney", "function", "\n", "Expected", "survival", "period=", "6", "months", "\n" ]

[ "Scope", "Measurement", "Observation", "Condition", "Procedure", "Value", "Qualifier", "Person" ]

Analyse is an umlsterm, Anaesthesieabteilung is an umlsterm, Krankenhausebene is an umlsterm, Anaesthesieabteilungen is an umlsterm

DerAnaesthesist.8047s087.ger.abstr_task0

Sentence: In dem vorliegenden Artikel werden die Kosten von Sevofluran im perioperativen Umfeld dargestellt . Die Analyse der Kosten fuer eine Anaesthesieabteilung im Vergleich zu den operativen Disziplinen auf Krankenhausebene zeigt i.d.R. einen proportionalen Anteil gemaess der Anzahl der verschiedenen Disziplinen , d.h. Anaesthesieabteilungen sind keine ueberproportional kostenintensiven Abteilungen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]

In dem vorliegenden Artikel werden die Kosten von Sevofluran im perioperativen Umfeld dargestellt . Die Analyse der Kosten fuer eine Anaesthesieabteilung im Vergleich zu den operativen Disziplinen auf Krankenhausebene zeigt i.d.R. einen proportionalen Anteil gemaess der Anzahl der verschiedenen Disziplinen , d.h. Anaesthesieabteilungen sind keine ueberproportional kostenintensiven Abteilungen .

[ "In", "dem", "vorliegenden", "Artikel", "werden", "die", "Kosten", "von", "Sevofluran", "im", "perioperativen", "Umfeld", "dargestellt", ".", "Die", "Analyse", "der", "Kosten", "fuer", "eine", "Anaesthesieabteilung", "im", "Vergleich", "zu", "den", "operativen", "Disziplinen", "auf", "Krankenhausebene", "zeigt", "i.d", ".", "R.", "einen", "proportionalen", "Anteil", "gemaess", "der", "Anzahl", "der", "verschiedenen", "Disziplinen", ",", "d.h", ".", "Anaesthesieabteilungen", "sind", "keine", "ueberproportional", "kostenintensiven", "Abteilungen", "." ]

[ "umlsterm" ]

Analyse is an umlsterm, Anaesthesieabteilung is an umlsterm, Krankenhausebene is an umlsterm, Anaesthesieabteilungen is an umlsterm

DerAnaesthesist.8047s087.ger.abstr_task1

Sentence: In dem vorliegenden Artikel werden die Kosten von Sevofluran im perioperativen Umfeld dargestellt . Die Analyse der Kosten fuer eine Anaesthesieabteilung im Vergleich zu den operativen Disziplinen auf Krankenhausebene zeigt i.d.R. einen proportionalen Anteil gemaess der Anzahl der verschiedenen Disziplinen , d.h. Anaesthesieabteilungen sind keine ueberproportional kostenintensiven Abteilungen . Instructions: please typing these entity words according to sentence: Analyse, Anaesthesieabteilung, Krankenhausebene, Anaesthesieabteilungen Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]

In dem vorliegenden Artikel werden die Kosten von Sevofluran im perioperativen Umfeld dargestellt . Die Analyse der Kosten fuer eine Anaesthesieabteilung im Vergleich zu den operativen Disziplinen auf Krankenhausebene zeigt i.d.R. einen proportionalen Anteil gemaess der Anzahl der verschiedenen Disziplinen , d.h. Anaesthesieabteilungen sind keine ueberproportional kostenintensiven Abteilungen .

[ "In", "dem", "vorliegenden", "Artikel", "werden", "die", "Kosten", "von", "Sevofluran", "im", "perioperativen", "Umfeld", "dargestellt", ".", "Die", "Analyse", "der", "Kosten", "fuer", "eine", "Anaesthesieabteilung", "im", "Vergleich", "zu", "den", "operativen", "Disziplinen", "auf", "Krankenhausebene", "zeigt", "i.d", ".", "R.", "einen", "proportionalen", "Anteil", "gemaess", "der", "Anzahl", "der", "verschiedenen", "Disziplinen", ",", "d.h", ".", "Anaesthesieabteilungen", "sind", "keine", "ueberproportional", "kostenintensiven", "Abteilungen", "." ]

[ "umlsterm" ]

Analyse, Anaesthesieabteilung, Krankenhausebene, Anaesthesieabteilungen

DerAnaesthesist.8047s087.ger.abstr_task2

Sentence: In dem vorliegenden Artikel werden die Kosten von Sevofluran im perioperativen Umfeld dargestellt . Die Analyse der Kosten fuer eine Anaesthesieabteilung im Vergleich zu den operativen Disziplinen auf Krankenhausebene zeigt i.d.R. einen proportionalen Anteil gemaess der Anzahl der verschiedenen Disziplinen , d.h. Anaesthesieabteilungen sind keine ueberproportional kostenintensiven Abteilungen . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]

In dem vorliegenden Artikel werden die Kosten von Sevofluran im perioperativen Umfeld dargestellt . Die Analyse der Kosten fuer eine Anaesthesieabteilung im Vergleich zu den operativen Disziplinen auf Krankenhausebene zeigt i.d.R. einen proportionalen Anteil gemaess der Anzahl der verschiedenen Disziplinen , d.h. Anaesthesieabteilungen sind keine ueberproportional kostenintensiven Abteilungen .

[ "In", "dem", "vorliegenden", "Artikel", "werden", "die", "Kosten", "von", "Sevofluran", "im", "perioperativen", "Umfeld", "dargestellt", ".", "Die", "Analyse", "der", "Kosten", "fuer", "eine", "Anaesthesieabteilung", "im", "Vergleich", "zu", "den", "operativen", "Disziplinen", "auf", "Krankenhausebene", "zeigt", "i.d", ".", "R.", "einen", "proportionalen", "Anteil", "gemaess", "der", "Anzahl", "der", "verschiedenen", "Disziplinen", ",", "d.h", ".", "Anaesthesieabteilungen", "sind", "keine", "ueberproportional", "kostenintensiven", "Abteilungen", "." ]

[ "umlsterm" ]

Kinase is a GENE-N, CK2 is a GENE-N

23210774_task0

Sentence: Kinase CK2 inhibition: an update. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N

[ "B-GENE-N", "B-GENE-N", "O", "O", "O", "O", "O" ]

Kinase CK2 inhibition: an update.

[ "Kinase", "CK2", "inhibition", ":", "an", "update", "." ]

[ "GENE-N", "CHEMICAL" ]

Kinase is a GENE-N, CK2 is a GENE-N

23210774_task1

Sentence: Kinase CK2 inhibition: an update. Instructions: please typing these entity words according to sentence: Kinase, CK2 Options: GENE-N

[ "B-GENE-N", "B-GENE-N", "O", "O", "O", "O", "O" ]

Kinase CK2 inhibition: an update.

[ "Kinase", "CK2", "inhibition", ":", "an", "update", "." ]

[ "GENE-N", "CHEMICAL" ]

Kinase, CK2

23210774_task2

Sentence: Kinase CK2 inhibition: an update. Instructions: please extract entity words from the input sentence

[ "B-GENE-N", "B-GENE-N", "O", "O", "O", "O", "O" ]

Kinase CK2 inhibition: an update.

[ "Kinase", "CK2", "inhibition", ":", "an", "update", "." ]

[ "GENE-N", "CHEMICAL" ]

patients is an umlsterm, radius fractures is an umlsterm, assistance is an umlsterm, patients is an umlsterm, ligaments is an umlsterm, I - tear is an umlsterm, patient is an umlsterm, patients is an umlsterm, arthrodesis is an umlsterm, patients is an umlsterm, Clinical examination is an umlsterm, range of motion is an umlsterm, tests is an umlsterm, questionnaire is an umlsterm, pain is an umlsterm, ability is an umlsterm, Objective is an umlsterm, grip is an umlsterm, wrist is an umlsterm, evaluation is an umlsterm, stress is an umlsterm, patients is an umlsterm, questionnaire is an umlsterm, patients is an umlsterm

Arthroskopie.90120313.eng.abstr_task0

Sentence: Since 1993 , 30 patients with acute intraarticular distal radius fractures have been treated under arthroscopic assistance . In 12 patients ( 40% ) concomitant lesions of the intrinsic scapholunate ligaments were diagnosed . According to Geissler we found grade I-tear in one patient , grade II in three , grade III in six and grade IV in two patients . The eight individuals with grade III-and IV-lesions additionally revealed marked instablity intraoperatively . Therefore , operative stabilization was subsequently performed by temporary scapholunate and scaphocapitate arthrodesis . Seven patients out of this group ( 87.5% ) were followed up clinically and radiologically 3 years postoperatively , on average . Clinical examination included range of motion tests and a subjective questionnaire concerning pain and working ability . Objective grip strength was measured using a Jamar tester and compared to the contralateral wrist . Radiological evaluation consisted of the posteroanterior and lateral view as well as stress views in radial and ulnar deviation . Data were evaluated by the Jakim and Cooney scoring system as well as the demerit point system by Gartland and Werley as modified by Sarmiento et al. According to Gartland , 100% of our patients showed an excellent result ; these rates were 86% using the Jakim score and 60% using the Cooney scoring system . According to the subjective questionnaire all of the patients revealed an excellent or good result . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Since 1993 , 30 patients with acute intraarticular distal radius fractures have been treated under arthroscopic assistance . In 12 patients ( 40% ) concomitant lesions of the intrinsic scapholunate ligaments were diagnosed . According to Geissler we found grade I-tear in one patient , grade II in three , grade III in six and grade IV in two patients . The eight individuals with grade III-and IV-lesions additionally revealed marked instablity intraoperatively . Therefore , operative stabilization was subsequently performed by temporary scapholunate and scaphocapitate arthrodesis . Seven patients out of this group ( 87.5% ) were followed up clinically and radiologically 3 years postoperatively , on average . Clinical examination included range of motion tests and a subjective questionnaire concerning pain and working ability . Objective grip strength was measured using a Jamar tester and compared to the contralateral wrist . Radiological evaluation consisted of the posteroanterior and lateral view as well as stress views in radial and ulnar deviation . Data were evaluated by the Jakim and Cooney scoring system as well as the demerit point system by Gartland and Werley as modified by Sarmiento et al. According to Gartland , 100% of our patients showed an excellent result ; these rates were 86% using the Jakim score and 60% using the Cooney scoring system . According to the subjective questionnaire all of the patients revealed an excellent or good result .

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[ "umlsterm" ]

patients is an umlsterm, radius fractures is an umlsterm, assistance is an umlsterm, patients is an umlsterm, ligaments is an umlsterm, I - tear is an umlsterm, patient is an umlsterm, patients is an umlsterm, arthrodesis is an umlsterm, patients is an umlsterm, Clinical examination is an umlsterm, range of motion is an umlsterm, tests is an umlsterm, questionnaire is an umlsterm, pain is an umlsterm, ability is an umlsterm, Objective is an umlsterm, grip is an umlsterm, wrist is an umlsterm, evaluation is an umlsterm, stress is an umlsterm, patients is an umlsterm, questionnaire is an umlsterm, patients is an umlsterm

Arthroskopie.90120313.eng.abstr_task1

Sentence: Since 1993 , 30 patients with acute intraarticular distal radius fractures have been treated under arthroscopic assistance . In 12 patients ( 40% ) concomitant lesions of the intrinsic scapholunate ligaments were diagnosed . According to Geissler we found grade I-tear in one patient , grade II in three , grade III in six and grade IV in two patients . The eight individuals with grade III-and IV-lesions additionally revealed marked instablity intraoperatively . Therefore , operative stabilization was subsequently performed by temporary scapholunate and scaphocapitate arthrodesis . Seven patients out of this group ( 87.5% ) were followed up clinically and radiologically 3 years postoperatively , on average . Clinical examination included range of motion tests and a subjective questionnaire concerning pain and working ability . Objective grip strength was measured using a Jamar tester and compared to the contralateral wrist . Radiological evaluation consisted of the posteroanterior and lateral view as well as stress views in radial and ulnar deviation . Data were evaluated by the Jakim and Cooney scoring system as well as the demerit point system by Gartland and Werley as modified by Sarmiento et al. According to Gartland , 100% of our patients showed an excellent result ; these rates were 86% using the Jakim score and 60% using the Cooney scoring system . According to the subjective questionnaire all of the patients revealed an excellent or good result . Instructions: please typing these entity words according to sentence: patients, radius fractures, assistance, patients, ligaments, I - tear, patient, patients, arthrodesis, patients, Clinical examination, range of motion, tests, questionnaire, pain, ability, Objective, grip, wrist, evaluation, stress, patients, questionnaire, patients Options: umlsterm

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Since 1993 , 30 patients with acute intraarticular distal radius fractures have been treated under arthroscopic assistance . In 12 patients ( 40% ) concomitant lesions of the intrinsic scapholunate ligaments were diagnosed . According to Geissler we found grade I-tear in one patient , grade II in three , grade III in six and grade IV in two patients . The eight individuals with grade III-and IV-lesions additionally revealed marked instablity intraoperatively . Therefore , operative stabilization was subsequently performed by temporary scapholunate and scaphocapitate arthrodesis . Seven patients out of this group ( 87.5% ) were followed up clinically and radiologically 3 years postoperatively , on average . Clinical examination included range of motion tests and a subjective questionnaire concerning pain and working ability . Objective grip strength was measured using a Jamar tester and compared to the contralateral wrist . Radiological evaluation consisted of the posteroanterior and lateral view as well as stress views in radial and ulnar deviation . Data were evaluated by the Jakim and Cooney scoring system as well as the demerit point system by Gartland and Werley as modified by Sarmiento et al. According to Gartland , 100% of our patients showed an excellent result ; these rates were 86% using the Jakim score and 60% using the Cooney scoring system . According to the subjective questionnaire all of the patients revealed an excellent or good result .

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[ "umlsterm" ]

patients, radius fractures, assistance, patients, ligaments, I - tear, patient, patients, arthrodesis, patients, Clinical examination, range of motion, tests, questionnaire, pain, ability, Objective, grip, wrist, evaluation, stress, patients, questionnaire, patients

Arthroskopie.90120313.eng.abstr_task2

Sentence: Since 1993 , 30 patients with acute intraarticular distal radius fractures have been treated under arthroscopic assistance . In 12 patients ( 40% ) concomitant lesions of the intrinsic scapholunate ligaments were diagnosed . According to Geissler we found grade I-tear in one patient , grade II in three , grade III in six and grade IV in two patients . The eight individuals with grade III-and IV-lesions additionally revealed marked instablity intraoperatively . Therefore , operative stabilization was subsequently performed by temporary scapholunate and scaphocapitate arthrodesis . Seven patients out of this group ( 87.5% ) were followed up clinically and radiologically 3 years postoperatively , on average . Clinical examination included range of motion tests and a subjective questionnaire concerning pain and working ability . Objective grip strength was measured using a Jamar tester and compared to the contralateral wrist . Radiological evaluation consisted of the posteroanterior and lateral view as well as stress views in radial and ulnar deviation . Data were evaluated by the Jakim and Cooney scoring system as well as the demerit point system by Gartland and Werley as modified by Sarmiento et al. According to Gartland , 100% of our patients showed an excellent result ; these rates were 86% using the Jakim score and 60% using the Cooney scoring system . According to the subjective questionnaire all of the patients revealed an excellent or good result . Instructions: please extract entity words from the input sentence

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Since 1993 , 30 patients with acute intraarticular distal radius fractures have been treated under arthroscopic assistance . In 12 patients ( 40% ) concomitant lesions of the intrinsic scapholunate ligaments were diagnosed . According to Geissler we found grade I-tear in one patient , grade II in three , grade III in six and grade IV in two patients . The eight individuals with grade III-and IV-lesions additionally revealed marked instablity intraoperatively . Therefore , operative stabilization was subsequently performed by temporary scapholunate and scaphocapitate arthrodesis . Seven patients out of this group ( 87.5% ) were followed up clinically and radiologically 3 years postoperatively , on average . Clinical examination included range of motion tests and a subjective questionnaire concerning pain and working ability . Objective grip strength was measured using a Jamar tester and compared to the contralateral wrist . Radiological evaluation consisted of the posteroanterior and lateral view as well as stress views in radial and ulnar deviation . Data were evaluated by the Jakim and Cooney scoring system as well as the demerit point system by Gartland and Werley as modified by Sarmiento et al. According to Gartland , 100% of our patients showed an excellent result ; these rates were 86% using the Jakim score and 60% using the Cooney scoring system . According to the subjective questionnaire all of the patients revealed an excellent or good result .

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[ "umlsterm" ]

complication is an umlsterm, trauma is an umlsterm, surgery is an umlsterm, connective tissue is an umlsterm, etiology is an umlsterm, pathogenesis is an umlsterm, fibroblasts is an umlsterm, proteins is an umlsterm, lung fibrosis is an umlsterm, fibromatoses is an umlsterm, collagen type VI is an umlsterm, tissue is an umlsterm, patients is an umlsterm, age is an umlsterm, knee joint is an umlsterm, ligament is an umlsterm, injury is an umlsterm, trauma is an umlsterm, Tissue is an umlsterm, fat is an umlsterm, connective tissue is an umlsterm, All is an umlsterm, collagen is an umlsterm, immunoperoxidase is an umlsterm, method is an umlsterm, light is an umlsterm, visualization is an umlsterm, Histologic is an umlsterm, analysis is an umlsterm, patients is an umlsterm, hyperplasia is an umlsterm, cell is an umlsterm, synovial tissue is an umlsterm, knee joints is an umlsterm, pathology is an umlsterm, proteins is an umlsterm, Type VI collagen is an umlsterm, capillary is an umlsterm, Type III collagen is an umlsterm, distribution is an umlsterm, tissue is an umlsterm, collagen type VI is an umlsterm, Collagen type VI is an umlsterm, role is an umlsterm, homeostasis is an umlsterm, element is an umlsterm, collagen is an umlsterm, cell is an umlsterm, binding is an umlsterm

DerUnfallchirurg.01030640.eng.abstr_task0

Sentence: Arthrofibrosis is a disabling complication after trauma and surgery due to massive connective tissue proliferation . The etiology and pathogenesis have never been fully understood . A strong immune response may lead to activation and proliferation of fibroblasts with excessive and disordered deposition of matrix proteins . In similar pathological conditions , like lung fibrosis or superficial fibromatoses with fibrotic transformation an increased expression of collagen type VI has been reported . We investigated fibrotic tissue samples taken from 18 patients ( average age : 32,7 years ) , who underwent arthrolysis of the knee joint because of symptomatic arthrofibrosis following ligament injury . The mean interval between trauma and arthrolysis was 13,8 months ( range 4-50 months ) . Tissue samples were taken from the infrapatellar fat pad and intercondylar connective tissue . All samples were stained with HE . The expression of type III and VI collagen was studied immunohistochemically using an immunoperoxidase method for light microscopic visualization . Histologic analysis from patients with arthrofibrosis showed a synovial hyperplasia with cell infiltration and vascular proliferation compared to synovial tissue samples from knee joints without any detectable pathology . Subsynovial an increased deposition of matrix proteins was visible . Type VI collagen was widely distributed as a network subsynovial and around capillary walls . Type III collagen showed a diffuse distribution . Arthrofibrotic tissue is , similar to pathological conditions with fibrotic transformation characterized by an increased expression of collagen type VI . Collagen type VI may play an important role in matrix homeostasis . It serves as an anchoring element between collagen fibers and as a cell binding structure . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Arthrofibrosis is a disabling complication after trauma and surgery due to massive connective tissue proliferation . The etiology and pathogenesis have never been fully understood . A strong immune response may lead to activation and proliferation of fibroblasts with excessive and disordered deposition of matrix proteins . In similar pathological conditions , like lung fibrosis or superficial fibromatoses with fibrotic transformation an increased expression of collagen type VI has been reported . We investigated fibrotic tissue samples taken from 18 patients ( average age : 32,7 years ) , who underwent arthrolysis of the knee joint because of symptomatic arthrofibrosis following ligament injury . The mean interval between trauma and arthrolysis was 13,8 months ( range 4-50 months ) . Tissue samples were taken from the infrapatellar fat pad and intercondylar connective tissue . All samples were stained with HE . The expression of type III and VI collagen was studied immunohistochemically using an immunoperoxidase method for light microscopic visualization . Histologic analysis from patients with arthrofibrosis showed a synovial hyperplasia with cell infiltration and vascular proliferation compared to synovial tissue samples from knee joints without any detectable pathology . Subsynovial an increased deposition of matrix proteins was visible . Type VI collagen was widely distributed as a network subsynovial and around capillary walls . Type III collagen showed a diffuse distribution . Arthrofibrotic tissue is , similar to pathological conditions with fibrotic transformation characterized by an increased expression of collagen type VI . Collagen type VI may play an important role in matrix homeostasis . It serves as an anchoring element between collagen fibers and as a cell binding structure .

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[ "umlsterm" ]

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DerUnfallchirurg.01030640.eng.abstr_task1

Sentence: Arthrofibrosis is a disabling complication after trauma and surgery due to massive connective tissue proliferation . The etiology and pathogenesis have never been fully understood . A strong immune response may lead to activation and proliferation of fibroblasts with excessive and disordered deposition of matrix proteins . In similar pathological conditions , like lung fibrosis or superficial fibromatoses with fibrotic transformation an increased expression of collagen type VI has been reported . We investigated fibrotic tissue samples taken from 18 patients ( average age : 32,7 years ) , who underwent arthrolysis of the knee joint because of symptomatic arthrofibrosis following ligament injury . The mean interval between trauma and arthrolysis was 13,8 months ( range 4-50 months ) . Tissue samples were taken from the infrapatellar fat pad and intercondylar connective tissue . All samples were stained with HE . The expression of type III and VI collagen was studied immunohistochemically using an immunoperoxidase method for light microscopic visualization . Histologic analysis from patients with arthrofibrosis showed a synovial hyperplasia with cell infiltration and vascular proliferation compared to synovial tissue samples from knee joints without any detectable pathology . Subsynovial an increased deposition of matrix proteins was visible . Type VI collagen was widely distributed as a network subsynovial and around capillary walls . Type III collagen showed a diffuse distribution . Arthrofibrotic tissue is , similar to pathological conditions with fibrotic transformation characterized by an increased expression of collagen type VI . Collagen type VI may play an important role in matrix homeostasis . It serves as an anchoring element between collagen fibers and as a cell binding structure . Instructions: please typing these entity words according to sentence: complication, trauma, surgery, connective tissue, etiology, pathogenesis, fibroblasts, proteins, lung fibrosis, fibromatoses, collagen type VI, tissue, patients, age, knee joint, ligament, injury, trauma, Tissue, fat, connective tissue, All, collagen, immunoperoxidase, method, light, visualization, Histologic, analysis, patients, hyperplasia, cell, synovial tissue, knee joints, pathology, proteins, Type VI collagen, capillary, Type III collagen, distribution, tissue, collagen type VI, Collagen type VI, role, homeostasis, element, collagen, cell, binding Options: umlsterm

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Arthrofibrosis is a disabling complication after trauma and surgery due to massive connective tissue proliferation . The etiology and pathogenesis have never been fully understood . A strong immune response may lead to activation and proliferation of fibroblasts with excessive and disordered deposition of matrix proteins . In similar pathological conditions , like lung fibrosis or superficial fibromatoses with fibrotic transformation an increased expression of collagen type VI has been reported . We investigated fibrotic tissue samples taken from 18 patients ( average age : 32,7 years ) , who underwent arthrolysis of the knee joint because of symptomatic arthrofibrosis following ligament injury . The mean interval between trauma and arthrolysis was 13,8 months ( range 4-50 months ) . Tissue samples were taken from the infrapatellar fat pad and intercondylar connective tissue . All samples were stained with HE . The expression of type III and VI collagen was studied immunohistochemically using an immunoperoxidase method for light microscopic visualization . Histologic analysis from patients with arthrofibrosis showed a synovial hyperplasia with cell infiltration and vascular proliferation compared to synovial tissue samples from knee joints without any detectable pathology . Subsynovial an increased deposition of matrix proteins was visible . Type VI collagen was widely distributed as a network subsynovial and around capillary walls . Type III collagen showed a diffuse distribution . Arthrofibrotic tissue is , similar to pathological conditions with fibrotic transformation characterized by an increased expression of collagen type VI . Collagen type VI may play an important role in matrix homeostasis . It serves as an anchoring element between collagen fibers and as a cell binding structure .

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[ "umlsterm" ]

complication, trauma, surgery, connective tissue, etiology, pathogenesis, fibroblasts, proteins, lung fibrosis, fibromatoses, collagen type VI, tissue, patients, age, knee joint, ligament, injury, trauma, Tissue, fat, connective tissue, All, collagen, immunoperoxidase, method, light, visualization, Histologic, analysis, patients, hyperplasia, cell, synovial tissue, knee joints, pathology, proteins, Type VI collagen, capillary, Type III collagen, distribution, tissue, collagen type VI, Collagen type VI, role, homeostasis, element, collagen, cell, binding

DerUnfallchirurg.01030640.eng.abstr_task2

Sentence: Arthrofibrosis is a disabling complication after trauma and surgery due to massive connective tissue proliferation . The etiology and pathogenesis have never been fully understood . A strong immune response may lead to activation and proliferation of fibroblasts with excessive and disordered deposition of matrix proteins . In similar pathological conditions , like lung fibrosis or superficial fibromatoses with fibrotic transformation an increased expression of collagen type VI has been reported . We investigated fibrotic tissue samples taken from 18 patients ( average age : 32,7 years ) , who underwent arthrolysis of the knee joint because of symptomatic arthrofibrosis following ligament injury . The mean interval between trauma and arthrolysis was 13,8 months ( range 4-50 months ) . Tissue samples were taken from the infrapatellar fat pad and intercondylar connective tissue . All samples were stained with HE . The expression of type III and VI collagen was studied immunohistochemically using an immunoperoxidase method for light microscopic visualization . Histologic analysis from patients with arthrofibrosis showed a synovial hyperplasia with cell infiltration and vascular proliferation compared to synovial tissue samples from knee joints without any detectable pathology . Subsynovial an increased deposition of matrix proteins was visible . Type VI collagen was widely distributed as a network subsynovial and around capillary walls . Type III collagen showed a diffuse distribution . Arthrofibrotic tissue is , similar to pathological conditions with fibrotic transformation characterized by an increased expression of collagen type VI . Collagen type VI may play an important role in matrix homeostasis . It serves as an anchoring element between collagen fibers and as a cell binding structure . Instructions: please extract entity words from the input sentence

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Arthrofibrosis is a disabling complication after trauma and surgery due to massive connective tissue proliferation . The etiology and pathogenesis have never been fully understood . A strong immune response may lead to activation and proliferation of fibroblasts with excessive and disordered deposition of matrix proteins . In similar pathological conditions , like lung fibrosis or superficial fibromatoses with fibrotic transformation an increased expression of collagen type VI has been reported . We investigated fibrotic tissue samples taken from 18 patients ( average age : 32,7 years ) , who underwent arthrolysis of the knee joint because of symptomatic arthrofibrosis following ligament injury . The mean interval between trauma and arthrolysis was 13,8 months ( range 4-50 months ) . Tissue samples were taken from the infrapatellar fat pad and intercondylar connective tissue . All samples were stained with HE . The expression of type III and VI collagen was studied immunohistochemically using an immunoperoxidase method for light microscopic visualization . Histologic analysis from patients with arthrofibrosis showed a synovial hyperplasia with cell infiltration and vascular proliferation compared to synovial tissue samples from knee joints without any detectable pathology . Subsynovial an increased deposition of matrix proteins was visible . Type VI collagen was widely distributed as a network subsynovial and around capillary walls . Type III collagen showed a diffuse distribution . Arthrofibrotic tissue is , similar to pathological conditions with fibrotic transformation characterized by an increased expression of collagen type VI . Collagen type VI may play an important role in matrix homeostasis . It serves as an anchoring element between collagen fibers and as a cell binding structure .

[ "Arthrofibrosis", "is", "a", "disabling", "complication", "after", "trauma", "and", "surgery", "due", "to", "massive", "connective", "tissue", "proliferation", ".", "The", "etiology", "and", "pathogenesis", "have", "never", "been", "fully", "understood", ".", "A", "strong", "immune", "response", "may", "lead", "to", "activation", "and", "proliferation", "of", "fibroblasts", "with", "excessive", "and", "disordered", "deposition", "of", "matrix", "proteins", ".", "In", "similar", "pathological", "conditions", ",", "like", "lung", "fibrosis", "or", "superficial", "fibromatoses", "with", "fibrotic", "transformation", "an", "increased", "expression", "of", "collagen", "type", "VI", "has", "been", "reported", ".", "We", "investigated", "fibrotic", "tissue", "samples", "taken", "from", "18", "patients", "(", "average", "age", ":", "32,7", "years", ")", ",", "who", "underwent", "arthrolysis", "of", "the", "knee", "joint", "because", "of", "symptomatic", "arthrofibrosis", "following", "ligament", "injury", ".", "The", "mean", "interval", "between", "trauma", "and", "arthrolysis", "was", "13,8", "months", "(", "range", "4", "-", "50", "months", ")", ".", "Tissue", "samples", "were", "taken", "from", "the", "infrapatellar", "fat", "pad", "and", "intercondylar", "connective", "tissue", ".", "All", "samples", "were", "stained", "with", "HE", ".", "The", "expression", "of", "type", "III", "and", "VI", "collagen", "was", "studied", "immunohistochemically", "using", "an", "immunoperoxidase", "method", "for", "light", "microscopic", "visualization", ".", "Histologic", "analysis", "from", "patients", "with", "arthrofibrosis", "showed", "a", "synovial", "hyperplasia", "with", "cell", "infiltration", "and", "vascular", "proliferation", "compared", "to", "synovial", "tissue", "samples", "from", "knee", "joints", "without", "any", "detectable", "pathology", ".", "Subsynovial", "an", "increased", "deposition", "of", "matrix", "proteins", "was", "visible", ".", "Type", "VI", "collagen", "was", "widely", "distributed", "as", "a", "network", "subsynovial", "and", "around", "capillary", "walls", ".", "Type", "III", "collagen", "showed", "a", "diffuse", "distribution", ".", "Arthrofibrotic", "tissue", "is", ",", "similar", "to", "pathological", "conditions", "with", "fibrotic", "transformation", "characterized", "by", "an", "increased", "expression", "of", "collagen", "type", "VI", ".", "Collagen", "type", "VI", "may", "play", "an", "important", "role", "in", "matrix", "homeostasis", ".", "It", "serves", "as", "an", "anchoring", "element", "between", "collagen", "fibers", "and", "as", "a", "cell", "binding", "structure", "." ]

[ "umlsterm" ]

proximal CD19 promoter is a DNA_domain_or_region, SP1 / Egr-1 binding site is a DNA_domain_or_region, PyG box is a DNA_domain_or_region

61610_task0

Sentence: In vivo footprinting and mutational analysis of the proximal CD19 promoter reveal important roles for an SP1/Egr-1 binding site and a novel site termed the PyG box. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: DNA_domain_or_region

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "O" ]

In vivo footprinting and mutational analysis of the proximal CD19 promoter reveal important roles for an SP1/Egr-1 binding site and a novel site termed the PyG box.

[ "In", "vivo", "footprinting", "and", "mutational", "analysis", "of", "the", "proximal", "CD19", "promoter", "reveal", "important", "roles", "for", "an", "SP1", "/", "Egr-1", "binding", "site", "and", "a", "novel", "site", "termed", "the", "PyG", "box", "." ]

[ "DNA_domain_or_region", "protein_molecule", "other_name", "DNA_molecule", "DNA_family_or_group", "(AND DNA_domain_or_region DNA_domain_or_region)", "cell_line", "cell_type", "other_organic_compound", "" ]

proximal CD19 promoter is a DNA_domain_or_region, SP1 / Egr-1 binding site is a DNA_domain_or_region, PyG box is a DNA_domain_or_region

61610_task1

Sentence: In vivo footprinting and mutational analysis of the proximal CD19 promoter reveal important roles for an SP1/Egr-1 binding site and a novel site termed the PyG box. Instructions: please typing these entity words according to sentence: proximal CD19 promoter, SP1 / Egr-1 binding site, PyG box Options: DNA_domain_or_region

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "O" ]

In vivo footprinting and mutational analysis of the proximal CD19 promoter reveal important roles for an SP1/Egr-1 binding site and a novel site termed the PyG box.

[ "In", "vivo", "footprinting", "and", "mutational", "analysis", "of", "the", "proximal", "CD19", "promoter", "reveal", "important", "roles", "for", "an", "SP1", "/", "Egr-1", "binding", "site", "and", "a", "novel", "site", "termed", "the", "PyG", "box", "." ]

[ "DNA_domain_or_region", "protein_molecule", "other_name", "DNA_molecule", "DNA_family_or_group", "(AND DNA_domain_or_region DNA_domain_or_region)", "cell_line", "cell_type", "other_organic_compound", "" ]

proximal CD19 promoter, SP1 / Egr-1 binding site, PyG box

61610_task2

Sentence: In vivo footprinting and mutational analysis of the proximal CD19 promoter reveal important roles for an SP1/Egr-1 binding site and a novel site termed the PyG box. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "O" ]

In vivo footprinting and mutational analysis of the proximal CD19 promoter reveal important roles for an SP1/Egr-1 binding site and a novel site termed the PyG box.

[ "In", "vivo", "footprinting", "and", "mutational", "analysis", "of", "the", "proximal", "CD19", "promoter", "reveal", "important", "roles", "for", "an", "SP1", "/", "Egr-1", "binding", "site", "and", "a", "novel", "site", "termed", "the", "PyG", "box", "." ]

[ "DNA_domain_or_region", "protein_molecule", "other_name", "DNA_molecule", "DNA_family_or_group", "(AND DNA_domain_or_region DNA_domain_or_region)", "cell_line", "cell_type", "other_organic_compound", "" ]

APC resistance is an umlsterm, form is an umlsterm, factor V is an umlsterm, factor V Leiden is an umlsterm, cause is an umlsterm, thrombosis is an umlsterm, association is an umlsterm, protein C is an umlsterm, retinal vein occlusion is an umlsterm, prevalence is an umlsterm, APC resistance is an umlsterm, patients is an umlsterm, patients is an umlsterm, history is an umlsterm, deep - vein thrombosis is an umlsterm, control group is an umlsterm

DerOpthalmologe.90960594.eng.abstr_task0

Sentence: Background : The recently described " APC resistance " caused by a mutant form of factor V ( factor V Leiden ) is the most frequent cause of hereditary thrombosis . This study was carried out to investigate the association between activated protein C resistance and central retinal vein occlusion ( CRVO ) . We evaluated the prevalence of APC resistance in patients with CRVO , patients with a history of deep-vein thrombosis , and a healthy control group . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]

Background : The recently described " APC resistance " caused by a mutant form of factor V ( factor V Leiden ) is the most frequent cause of hereditary thrombosis . This study was carried out to investigate the association between activated protein C resistance and central retinal vein occlusion ( CRVO ) . We evaluated the prevalence of APC resistance in patients with CRVO , patients with a history of deep-vein thrombosis , and a healthy control group .

[ "Background", ":", "The", "recently", "described", "\"", "APC", "resistance", "\"", "caused", "by", "a", "mutant", "form", "of", "factor", "V", "(", "factor", "V", "Leiden", ")", "is", "the", "most", "frequent", "cause", "of", "hereditary", "thrombosis", ".", "This", "study", "was", "carried", "out", "to", "investigate", "the", "association", "between", "activated", "protein", "C", "resistance", "and", "central", "retinal", "vein", "occlusion", "(", "CRVO", ")", ".", "We", "evaluated", "the", "prevalence", "of", "APC", "resistance", "in", "patients", "with", "CRVO", ",", "patients", "with", "a", "history", "of", "deep", "-", "vein", "thrombosis", ",", "and", "a", "healthy", "control", "group", "." ]

[ "umlsterm" ]

APC resistance is an umlsterm, form is an umlsterm, factor V is an umlsterm, factor V Leiden is an umlsterm, cause is an umlsterm, thrombosis is an umlsterm, association is an umlsterm, protein C is an umlsterm, retinal vein occlusion is an umlsterm, prevalence is an umlsterm, APC resistance is an umlsterm, patients is an umlsterm, patients is an umlsterm, history is an umlsterm, deep - vein thrombosis is an umlsterm, control group is an umlsterm

DerOpthalmologe.90960594.eng.abstr_task1

Sentence: Background : The recently described " APC resistance " caused by a mutant form of factor V ( factor V Leiden ) is the most frequent cause of hereditary thrombosis . This study was carried out to investigate the association between activated protein C resistance and central retinal vein occlusion ( CRVO ) . We evaluated the prevalence of APC resistance in patients with CRVO , patients with a history of deep-vein thrombosis , and a healthy control group . Instructions: please typing these entity words according to sentence: APC resistance, form, factor V, factor V Leiden, cause, thrombosis, association, protein C, retinal vein occlusion, prevalence, APC resistance, patients, patients, history, deep - vein thrombosis, control group Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]

Background : The recently described " APC resistance " caused by a mutant form of factor V ( factor V Leiden ) is the most frequent cause of hereditary thrombosis . This study was carried out to investigate the association between activated protein C resistance and central retinal vein occlusion ( CRVO ) . We evaluated the prevalence of APC resistance in patients with CRVO , patients with a history of deep-vein thrombosis , and a healthy control group .

[ "Background", ":", "The", "recently", "described", "\"", "APC", "resistance", "\"", "caused", "by", "a", "mutant", "form", "of", "factor", "V", "(", "factor", "V", "Leiden", ")", "is", "the", "most", "frequent", "cause", "of", "hereditary", "thrombosis", ".", "This", "study", "was", "carried", "out", "to", "investigate", "the", "association", "between", "activated", "protein", "C", "resistance", "and", "central", "retinal", "vein", "occlusion", "(", "CRVO", ")", ".", "We", "evaluated", "the", "prevalence", "of", "APC", "resistance", "in", "patients", "with", "CRVO", ",", "patients", "with", "a", "history", "of", "deep", "-", "vein", "thrombosis", ",", "and", "a", "healthy", "control", "group", "." ]

[ "umlsterm" ]

APC resistance, form, factor V, factor V Leiden, cause, thrombosis, association, protein C, retinal vein occlusion, prevalence, APC resistance, patients, patients, history, deep - vein thrombosis, control group

DerOpthalmologe.90960594.eng.abstr_task2

Sentence: Background : The recently described " APC resistance " caused by a mutant form of factor V ( factor V Leiden ) is the most frequent cause of hereditary thrombosis . This study was carried out to investigate the association between activated protein C resistance and central retinal vein occlusion ( CRVO ) . We evaluated the prevalence of APC resistance in patients with CRVO , patients with a history of deep-vein thrombosis , and a healthy control group . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]

Background : The recently described " APC resistance " caused by a mutant form of factor V ( factor V Leiden ) is the most frequent cause of hereditary thrombosis . This study was carried out to investigate the association between activated protein C resistance and central retinal vein occlusion ( CRVO ) . We evaluated the prevalence of APC resistance in patients with CRVO , patients with a history of deep-vein thrombosis , and a healthy control group .

[ "Background", ":", "The", "recently", "described", "\"", "APC", "resistance", "\"", "caused", "by", "a", "mutant", "form", "of", "factor", "V", "(", "factor", "V", "Leiden", ")", "is", "the", "most", "frequent", "cause", "of", "hereditary", "thrombosis", ".", "This", "study", "was", "carried", "out", "to", "investigate", "the", "association", "between", "activated", "protein", "C", "resistance", "and", "central", "retinal", "vein", "occlusion", "(", "CRVO", ")", ".", "We", "evaluated", "the", "prevalence", "of", "APC", "resistance", "in", "patients", "with", "CRVO", ",", "patients", "with", "a", "history", "of", "deep", "-", "vein", "thrombosis", ",", "and", "a", "healthy", "control", "group", "." ]

[ "umlsterm" ]

ginsenoside Rg3 is a compound, AMPK is a protein, PPAR - gamma is a protein

DS.d1580_task0

Sentence: Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR-gamma signal pathways. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein

[ "O", "O", "O", "B-compound", "I-compound", "O", "O", "B-protein", "O", "B-protein", "I-protein", "I-protein", "O", "O", "O" ]

Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR-gamma signal pathways.

[ "Antiobesity", "effect", "of", "ginsenoside", "Rg3", "involves", "the", "AMPK", "and", "PPAR", "-", "gamma", "signal", "pathways", "." ]

[ "compound", "protein" ]

ginsenoside Rg3 is a compound, AMPK is a protein, PPAR - gamma is a protein

DS.d1580_task1

Sentence: Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR-gamma signal pathways. Instructions: please typing these entity words according to sentence: ginsenoside Rg3, AMPK, PPAR - gamma Options: compound, protein

[ "O", "O", "O", "B-compound", "I-compound", "O", "O", "B-protein", "O", "B-protein", "I-protein", "I-protein", "O", "O", "O" ]

Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR-gamma signal pathways.

[ "Antiobesity", "effect", "of", "ginsenoside", "Rg3", "involves", "the", "AMPK", "and", "PPAR", "-", "gamma", "signal", "pathways", "." ]

[ "compound", "protein" ]

ginsenoside Rg3, AMPK, PPAR - gamma

DS.d1580_task2

Sentence: Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR-gamma signal pathways. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "B-compound", "I-compound", "O", "O", "B-protein", "O", "B-protein", "I-protein", "I-protein", "O", "O", "O" ]

Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR-gamma signal pathways.

[ "Antiobesity", "effect", "of", "ginsenoside", "Rg3", "involves", "the", "AMPK", "and", "PPAR", "-", "gamma", "signal", "pathways", "." ]

[ "compound", "protein" ]

iron dextran is a compound, Hamp is a protein

DS.d729_task0

Sentence: Macrophages isolated from iron deficient rats, or pregnant rats at day 21 of gestation, either supplemented with a single dose of iron dextran, 10 mg, at the commencement of pregnancy, or not, showed significant increases of macrophage ferroportin mRNA expression, which was paralleled by significant decreases in hepatic Hamp mRNA expression. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O" ]

Macrophages isolated from iron deficient rats, or pregnant rats at day 21 of gestation, either supplemented with a single dose of iron dextran, 10 mg, at the commencement of pregnancy, or not, showed significant increases of macrophage ferroportin mRNA expression, which was paralleled by significant decreases in hepatic Hamp mRNA expression.

[ "Macrophages", "isolated", "from", "iron", "deficient", "rats", ",", "or", "pregnant", "rats", "at", "day", "21", "of", "gestation", ",", "either", "supplemented", "with", "a", "single", "dose", "of", "iron", "dextran", ",", "10", "mg", ",", "at", "the", "commencement", "of", "pregnancy", ",", "or", "not", ",", "showed", "significant", "increases", "of", "macrophage", "ferroportin", "mRNA", "expression", ",", "which", "was", "paralleled", "by", "significant", "decreases", "in", "hepatic", "Hamp", "mRNA", "expression", "." ]

[ "compound", "protein" ]

iron dextran is a compound, Hamp is a protein

DS.d729_task1

Sentence: Macrophages isolated from iron deficient rats, or pregnant rats at day 21 of gestation, either supplemented with a single dose of iron dextran, 10 mg, at the commencement of pregnancy, or not, showed significant increases of macrophage ferroportin mRNA expression, which was paralleled by significant decreases in hepatic Hamp mRNA expression. Instructions: please typing these entity words according to sentence: iron dextran, Hamp Options: compound, protein

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Macrophages isolated from iron deficient rats, or pregnant rats at day 21 of gestation, either supplemented with a single dose of iron dextran, 10 mg, at the commencement of pregnancy, or not, showed significant increases of macrophage ferroportin mRNA expression, which was paralleled by significant decreases in hepatic Hamp mRNA expression.

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[ "compound", "protein" ]

iron dextran, Hamp

DS.d729_task2

Sentence: Macrophages isolated from iron deficient rats, or pregnant rats at day 21 of gestation, either supplemented with a single dose of iron dextran, 10 mg, at the commencement of pregnancy, or not, showed significant increases of macrophage ferroportin mRNA expression, which was paralleled by significant decreases in hepatic Hamp mRNA expression. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-compound", "I-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-protein", "O", "O", "O" ]

Macrophages isolated from iron deficient rats, or pregnant rats at day 21 of gestation, either supplemented with a single dose of iron dextran, 10 mg, at the commencement of pregnancy, or not, showed significant increases of macrophage ferroportin mRNA expression, which was paralleled by significant decreases in hepatic Hamp mRNA expression.

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[ "compound", "protein" ]

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ZfuerGerontologie+Geriatrie.00330169.eng.abstr_task0

Sentence: This article examines the use and acceptance of ticket machines , automatic teller machines ( ATMs ) and telephone cards by the elderly in four European regions . The analyses are based on data from an international project entitled " Keeping the Elderly Mobile " , collected in Mannheim ( former West Germany ; N=404 home-dwelling respondents ) , Chemnitz ( former East Germany ; N=400), Ancona ( Italy ; N=600), and Jyvaeskylae ( Finland ; N=618). The random sample was stratified by age and gender in each country . Two generations of men and women ( aged 55-74 and 75+ years , respectively ) participated in the study . Results show that respondents generally made little use of the three technologies under investigation : in fact , the majority of respondents does not use them at all . The most frequently used devices were ATMs in Chemnitz and ticket machines and telephone cards in Mannheim . On the basis of logistic regression analysis , age was the most important explanatory factor for the three technologies and for all four regions , i.e. , the users were mostly the " young-old . " Education was a more important variable than gender . In all four regions , the majority of the respondents who used the technologies assessed felt that each of them made life easier ; nevertheless , ticket machines make life more difficult to almost every third user in Mannheim . Interesting differences and similarities among the towns were also found . The present study exhibits preliminary results regarding elderly and technology which future research should investigate in greater depth . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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This article examines the use and acceptance of ticket machines , automatic teller machines ( ATMs ) and telephone cards by the elderly in four European regions . The analyses are based on data from an international project entitled " Keeping the Elderly Mobile " , collected in Mannheim ( former West Germany ; N=404 home-dwelling respondents ) , Chemnitz ( former East Germany ; N=400), Ancona ( Italy ; N=600), and Jyvaeskylae ( Finland ; N=618). The random sample was stratified by age and gender in each country . Two generations of men and women ( aged 55-74 and 75+ years , respectively ) participated in the study . Results show that respondents generally made little use of the three technologies under investigation : in fact , the majority of respondents does not use them at all . The most frequently used devices were ATMs in Chemnitz and ticket machines and telephone cards in Mannheim . On the basis of logistic regression analysis , age was the most important explanatory factor for the three technologies and for all four regions , i.e. , the users were mostly the " young-old . " Education was a more important variable than gender . In all four regions , the majority of the respondents who used the technologies assessed felt that each of them made life easier ; nevertheless , ticket machines make life more difficult to almost every third user in Mannheim . Interesting differences and similarities among the towns were also found . The present study exhibits preliminary results regarding elderly and technology which future research should investigate in greater depth .

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[ "umlsterm" ]

use is an umlsterm, telephone is an umlsterm, elderly is an umlsterm, analyses is an umlsterm, Elderly is an umlsterm, West Germany is an umlsterm, respondents is an umlsterm, East Germany is an umlsterm, Italy is an umlsterm, Finland is an umlsterm, age is an umlsterm, gender is an umlsterm, generations is an umlsterm, men is an umlsterm, women is an umlsterm, respondents is an umlsterm, use is an umlsterm, technologies is an umlsterm, respondents is an umlsterm, devices is an umlsterm, telephone is an umlsterm, logistic regression is an umlsterm, analysis is an umlsterm, age is an umlsterm, technologies is an umlsterm, young - old is an umlsterm, Education is an umlsterm, gender is an umlsterm, respondents is an umlsterm, technologies is an umlsterm, life is an umlsterm, life is an umlsterm, elderly is an umlsterm, technology is an umlsterm, future is an umlsterm, research is an umlsterm

ZfuerGerontologie+Geriatrie.00330169.eng.abstr_task1

Sentence: This article examines the use and acceptance of ticket machines , automatic teller machines ( ATMs ) and telephone cards by the elderly in four European regions . The analyses are based on data from an international project entitled " Keeping the Elderly Mobile " , collected in Mannheim ( former West Germany ; N=404 home-dwelling respondents ) , Chemnitz ( former East Germany ; N=400), Ancona ( Italy ; N=600), and Jyvaeskylae ( Finland ; N=618). The random sample was stratified by age and gender in each country . Two generations of men and women ( aged 55-74 and 75+ years , respectively ) participated in the study . Results show that respondents generally made little use of the three technologies under investigation : in fact , the majority of respondents does not use them at all . The most frequently used devices were ATMs in Chemnitz and ticket machines and telephone cards in Mannheim . On the basis of logistic regression analysis , age was the most important explanatory factor for the three technologies and for all four regions , i.e. , the users were mostly the " young-old . " Education was a more important variable than gender . In all four regions , the majority of the respondents who used the technologies assessed felt that each of them made life easier ; nevertheless , ticket machines make life more difficult to almost every third user in Mannheim . Interesting differences and similarities among the towns were also found . The present study exhibits preliminary results regarding elderly and technology which future research should investigate in greater depth . Instructions: please typing these entity words according to sentence: use, telephone, elderly, analyses, Elderly, West Germany, respondents, East Germany, Italy, Finland, age, gender, generations, men, women, respondents, use, technologies, respondents, devices, telephone, logistic regression, analysis, age, technologies, young - old, Education, gender, respondents, technologies, life, life, elderly, technology, future, research Options: umlsterm

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This article examines the use and acceptance of ticket machines , automatic teller machines ( ATMs ) and telephone cards by the elderly in four European regions . The analyses are based on data from an international project entitled " Keeping the Elderly Mobile " , collected in Mannheim ( former West Germany ; N=404 home-dwelling respondents ) , Chemnitz ( former East Germany ; N=400), Ancona ( Italy ; N=600), and Jyvaeskylae ( Finland ; N=618). The random sample was stratified by age and gender in each country . Two generations of men and women ( aged 55-74 and 75+ years , respectively ) participated in the study . Results show that respondents generally made little use of the three technologies under investigation : in fact , the majority of respondents does not use them at all . The most frequently used devices were ATMs in Chemnitz and ticket machines and telephone cards in Mannheim . On the basis of logistic regression analysis , age was the most important explanatory factor for the three technologies and for all four regions , i.e. , the users were mostly the " young-old . " Education was a more important variable than gender . In all four regions , the majority of the respondents who used the technologies assessed felt that each of them made life easier ; nevertheless , ticket machines make life more difficult to almost every third user in Mannheim . Interesting differences and similarities among the towns were also found . The present study exhibits preliminary results regarding elderly and technology which future research should investigate in greater depth .

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[ "umlsterm" ]

use, telephone, elderly, analyses, Elderly, West Germany, respondents, East Germany, Italy, Finland, age, gender, generations, men, women, respondents, use, technologies, respondents, devices, telephone, logistic regression, analysis, age, technologies, young - old, Education, gender, respondents, technologies, life, life, elderly, technology, future, research

ZfuerGerontologie+Geriatrie.00330169.eng.abstr_task2

Sentence: This article examines the use and acceptance of ticket machines , automatic teller machines ( ATMs ) and telephone cards by the elderly in four European regions . The analyses are based on data from an international project entitled " Keeping the Elderly Mobile " , collected in Mannheim ( former West Germany ; N=404 home-dwelling respondents ) , Chemnitz ( former East Germany ; N=400), Ancona ( Italy ; N=600), and Jyvaeskylae ( Finland ; N=618). The random sample was stratified by age and gender in each country . Two generations of men and women ( aged 55-74 and 75+ years , respectively ) participated in the study . Results show that respondents generally made little use of the three technologies under investigation : in fact , the majority of respondents does not use them at all . The most frequently used devices were ATMs in Chemnitz and ticket machines and telephone cards in Mannheim . On the basis of logistic regression analysis , age was the most important explanatory factor for the three technologies and for all four regions , i.e. , the users were mostly the " young-old . " Education was a more important variable than gender . In all four regions , the majority of the respondents who used the technologies assessed felt that each of them made life easier ; nevertheless , ticket machines make life more difficult to almost every third user in Mannheim . Interesting differences and similarities among the towns were also found . The present study exhibits preliminary results regarding elderly and technology which future research should investigate in greater depth . Instructions: please extract entity words from the input sentence

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This article examines the use and acceptance of ticket machines , automatic teller machines ( ATMs ) and telephone cards by the elderly in four European regions . The analyses are based on data from an international project entitled " Keeping the Elderly Mobile " , collected in Mannheim ( former West Germany ; N=404 home-dwelling respondents ) , Chemnitz ( former East Germany ; N=400), Ancona ( Italy ; N=600), and Jyvaeskylae ( Finland ; N=618). The random sample was stratified by age and gender in each country . Two generations of men and women ( aged 55-74 and 75+ years , respectively ) participated in the study . Results show that respondents generally made little use of the three technologies under investigation : in fact , the majority of respondents does not use them at all . The most frequently used devices were ATMs in Chemnitz and ticket machines and telephone cards in Mannheim . On the basis of logistic regression analysis , age was the most important explanatory factor for the three technologies and for all four regions , i.e. , the users were mostly the " young-old . " Education was a more important variable than gender . In all four regions , the majority of the respondents who used the technologies assessed felt that each of them made life easier ; nevertheless , ticket machines make life more difficult to almost every third user in Mannheim . Interesting differences and similarities among the towns were also found . The present study exhibits preliminary results regarding elderly and technology which future research should investigate in greater depth .

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[ "umlsterm" ]

Gelenkinfekten is an umlsterm, unfallchirurgischen is an umlsterm, Methoden is an umlsterm, gezielte is an umlsterm, kombinierten Therapie is an umlsterm, Hueftgelenkersatz is an umlsterm, Chemotherapie is an umlsterm, Therapieergebnisses is an umlsterm, Literatur is an umlsterm

DerUnfallchirurg.01030401.ger.abstr_task0

Sentence: Die Moeglichkeit einer spezifischen Genese von Gelenkinfekten und Spondylitiden ist in die differentialdiagnostischen Ueberlegungen einzubeziehen . Dies wird anhand eines Falls einer Coxitis tuberculosa demonstriert , welcher in Zusammenarbeit der unfallchirurgischen mit der medizinischen Klinik des Klinikums Minden therapiert wurde . Ein differenziertes diagnostisches Vorgehen mit bildgebenden und mikrobiologischen Methoden erlaubt eine gezielte Planung und Durchfuehrung einer kombinierten Therapie aus operativem endoprothetischen Hueftgelenkersatz und antituberkuloeser Chemotherapie . Nach kritischer Bewertung des Therapieergebnisses und Diskussion der Literatur ist das praesentierte Vorgehen erfolgreich , sowohl die lokale Sanierung des Infekts , als auch das funktionelle Ergebnis betreffend . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Die Moeglichkeit einer spezifischen Genese von Gelenkinfekten und Spondylitiden ist in die differentialdiagnostischen Ueberlegungen einzubeziehen . Dies wird anhand eines Falls einer Coxitis tuberculosa demonstriert , welcher in Zusammenarbeit der unfallchirurgischen mit der medizinischen Klinik des Klinikums Minden therapiert wurde . Ein differenziertes diagnostisches Vorgehen mit bildgebenden und mikrobiologischen Methoden erlaubt eine gezielte Planung und Durchfuehrung einer kombinierten Therapie aus operativem endoprothetischen Hueftgelenkersatz und antituberkuloeser Chemotherapie . Nach kritischer Bewertung des Therapieergebnisses und Diskussion der Literatur ist das praesentierte Vorgehen erfolgreich , sowohl die lokale Sanierung des Infekts , als auch das funktionelle Ergebnis betreffend .

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[ "umlsterm" ]

Gelenkinfekten is an umlsterm, unfallchirurgischen is an umlsterm, Methoden is an umlsterm, gezielte is an umlsterm, kombinierten Therapie is an umlsterm, Hueftgelenkersatz is an umlsterm, Chemotherapie is an umlsterm, Therapieergebnisses is an umlsterm, Literatur is an umlsterm

DerUnfallchirurg.01030401.ger.abstr_task1

Sentence: Die Moeglichkeit einer spezifischen Genese von Gelenkinfekten und Spondylitiden ist in die differentialdiagnostischen Ueberlegungen einzubeziehen . Dies wird anhand eines Falls einer Coxitis tuberculosa demonstriert , welcher in Zusammenarbeit der unfallchirurgischen mit der medizinischen Klinik des Klinikums Minden therapiert wurde . Ein differenziertes diagnostisches Vorgehen mit bildgebenden und mikrobiologischen Methoden erlaubt eine gezielte Planung und Durchfuehrung einer kombinierten Therapie aus operativem endoprothetischen Hueftgelenkersatz und antituberkuloeser Chemotherapie . Nach kritischer Bewertung des Therapieergebnisses und Diskussion der Literatur ist das praesentierte Vorgehen erfolgreich , sowohl die lokale Sanierung des Infekts , als auch das funktionelle Ergebnis betreffend . Instructions: please typing these entity words according to sentence: Gelenkinfekten, unfallchirurgischen, Methoden, gezielte, kombinierten Therapie, Hueftgelenkersatz, Chemotherapie, Therapieergebnisses, Literatur Options: umlsterm

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Die Moeglichkeit einer spezifischen Genese von Gelenkinfekten und Spondylitiden ist in die differentialdiagnostischen Ueberlegungen einzubeziehen . Dies wird anhand eines Falls einer Coxitis tuberculosa demonstriert , welcher in Zusammenarbeit der unfallchirurgischen mit der medizinischen Klinik des Klinikums Minden therapiert wurde . Ein differenziertes diagnostisches Vorgehen mit bildgebenden und mikrobiologischen Methoden erlaubt eine gezielte Planung und Durchfuehrung einer kombinierten Therapie aus operativem endoprothetischen Hueftgelenkersatz und antituberkuloeser Chemotherapie . Nach kritischer Bewertung des Therapieergebnisses und Diskussion der Literatur ist das praesentierte Vorgehen erfolgreich , sowohl die lokale Sanierung des Infekts , als auch das funktionelle Ergebnis betreffend .

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[ "umlsterm" ]

Gelenkinfekten, unfallchirurgischen, Methoden, gezielte, kombinierten Therapie, Hueftgelenkersatz, Chemotherapie, Therapieergebnisses, Literatur

DerUnfallchirurg.01030401.ger.abstr_task2

Sentence: Die Moeglichkeit einer spezifischen Genese von Gelenkinfekten und Spondylitiden ist in die differentialdiagnostischen Ueberlegungen einzubeziehen . Dies wird anhand eines Falls einer Coxitis tuberculosa demonstriert , welcher in Zusammenarbeit der unfallchirurgischen mit der medizinischen Klinik des Klinikums Minden therapiert wurde . Ein differenziertes diagnostisches Vorgehen mit bildgebenden und mikrobiologischen Methoden erlaubt eine gezielte Planung und Durchfuehrung einer kombinierten Therapie aus operativem endoprothetischen Hueftgelenkersatz und antituberkuloeser Chemotherapie . Nach kritischer Bewertung des Therapieergebnisses und Diskussion der Literatur ist das praesentierte Vorgehen erfolgreich , sowohl die lokale Sanierung des Infekts , als auch das funktionelle Ergebnis betreffend . Instructions: please extract entity words from the input sentence

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Die Moeglichkeit einer spezifischen Genese von Gelenkinfekten und Spondylitiden ist in die differentialdiagnostischen Ueberlegungen einzubeziehen . Dies wird anhand eines Falls einer Coxitis tuberculosa demonstriert , welcher in Zusammenarbeit der unfallchirurgischen mit der medizinischen Klinik des Klinikums Minden therapiert wurde . Ein differenziertes diagnostisches Vorgehen mit bildgebenden und mikrobiologischen Methoden erlaubt eine gezielte Planung und Durchfuehrung einer kombinierten Therapie aus operativem endoprothetischen Hueftgelenkersatz und antituberkuloeser Chemotherapie . Nach kritischer Bewertung des Therapieergebnisses und Diskussion der Literatur ist das praesentierte Vorgehen erfolgreich , sowohl die lokale Sanierung des Infekts , als auch das funktionelle Ergebnis betreffend .

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[ "umlsterm" ]

Effizienz is an umlsterm, Geburtseinleitung is an umlsterm, Muttermundsverhaeltnissen is an umlsterm, Geburtseinleitung is an umlsterm

PerinatalMedizin.80100081.ger.abstr_task0

Sentence: Im Rahmen einer prospektiven randomisierten Multicenterstudie wurde bei 796 Patientinnen die Effizienz der Geburtseinleitung mittels 2 mg PGE2-Vaginalgel vs. 0,5 mg Intrazervikalgel bei unreifer Zervix ( Bishop-Score 3-4 ) und von 2 mg PGE2-Vaginalgel vs. der 3 mg PGE2-Vaginaltablette bei reifer Zervix ( Bishop-Score 5-7 ) vergleichend untersucht . Bei unreifen Muttermundsverhaeltnissen wies das 2 mg PGE2-Vaginalgel hinsichtlich des Reifungseffekts , der medianen Induktionsgeburtsintervalle und der kumulativen Entbindungsraten/24 h signifikant bessere Ergebnisse auf als das Intrazervikalgel ; keine signifikanten Unterschiede ergaben sich in der Haeufigkeit uteriner Ueberstimulierungen , unerwuenschter maternaler Begleitwirkungen , der Sectiorate und im fetal outcome " . " Bei reifer Zervix erwiesen sich das 2 mg PGE2-Vaginalgel und die 3 mg PGE2-Vaginaltablette als aequieffektiv . Mit dem 2 mg PGE2-Vaginalgel steht eine effiziente Applikationsform fuer die Geburtseinleitung ab einem Bishop-Score > =3 zur Verfuegung . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Im Rahmen einer prospektiven randomisierten Multicenterstudie wurde bei 796 Patientinnen die Effizienz der Geburtseinleitung mittels 2 mg PGE2-Vaginalgel vs. 0,5 mg Intrazervikalgel bei unreifer Zervix ( Bishop-Score 3-4 ) und von 2 mg PGE2-Vaginalgel vs. der 3 mg PGE2-Vaginaltablette bei reifer Zervix ( Bishop-Score 5-7 ) vergleichend untersucht . Bei unreifen Muttermundsverhaeltnissen wies das 2 mg PGE2-Vaginalgel hinsichtlich des Reifungseffekts , der medianen Induktionsgeburtsintervalle und der kumulativen Entbindungsraten/24 h signifikant bessere Ergebnisse auf als das Intrazervikalgel ; keine signifikanten Unterschiede ergaben sich in der Haeufigkeit uteriner Ueberstimulierungen , unerwuenschter maternaler Begleitwirkungen , der Sectiorate und im fetal outcome " . " Bei reifer Zervix erwiesen sich das 2 mg PGE2-Vaginalgel und die 3 mg PGE2-Vaginaltablette als aequieffektiv . Mit dem 2 mg PGE2-Vaginalgel steht eine effiziente Applikationsform fuer die Geburtseinleitung ab einem Bishop-Score > =3 zur Verfuegung .

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[ "umlsterm" ]

Effizienz is an umlsterm, Geburtseinleitung is an umlsterm, Muttermundsverhaeltnissen is an umlsterm, Geburtseinleitung is an umlsterm

PerinatalMedizin.80100081.ger.abstr_task1

Sentence: Im Rahmen einer prospektiven randomisierten Multicenterstudie wurde bei 796 Patientinnen die Effizienz der Geburtseinleitung mittels 2 mg PGE2-Vaginalgel vs. 0,5 mg Intrazervikalgel bei unreifer Zervix ( Bishop-Score 3-4 ) und von 2 mg PGE2-Vaginalgel vs. der 3 mg PGE2-Vaginaltablette bei reifer Zervix ( Bishop-Score 5-7 ) vergleichend untersucht . Bei unreifen Muttermundsverhaeltnissen wies das 2 mg PGE2-Vaginalgel hinsichtlich des Reifungseffekts , der medianen Induktionsgeburtsintervalle und der kumulativen Entbindungsraten/24 h signifikant bessere Ergebnisse auf als das Intrazervikalgel ; keine signifikanten Unterschiede ergaben sich in der Haeufigkeit uteriner Ueberstimulierungen , unerwuenschter maternaler Begleitwirkungen , der Sectiorate und im fetal outcome " . " Bei reifer Zervix erwiesen sich das 2 mg PGE2-Vaginalgel und die 3 mg PGE2-Vaginaltablette als aequieffektiv . Mit dem 2 mg PGE2-Vaginalgel steht eine effiziente Applikationsform fuer die Geburtseinleitung ab einem Bishop-Score > =3 zur Verfuegung . Instructions: please typing these entity words according to sentence: Effizienz, Geburtseinleitung, Muttermundsverhaeltnissen, Geburtseinleitung Options: umlsterm

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Im Rahmen einer prospektiven randomisierten Multicenterstudie wurde bei 796 Patientinnen die Effizienz der Geburtseinleitung mittels 2 mg PGE2-Vaginalgel vs. 0,5 mg Intrazervikalgel bei unreifer Zervix ( Bishop-Score 3-4 ) und von 2 mg PGE2-Vaginalgel vs. der 3 mg PGE2-Vaginaltablette bei reifer Zervix ( Bishop-Score 5-7 ) vergleichend untersucht . Bei unreifen Muttermundsverhaeltnissen wies das 2 mg PGE2-Vaginalgel hinsichtlich des Reifungseffekts , der medianen Induktionsgeburtsintervalle und der kumulativen Entbindungsraten/24 h signifikant bessere Ergebnisse auf als das Intrazervikalgel ; keine signifikanten Unterschiede ergaben sich in der Haeufigkeit uteriner Ueberstimulierungen , unerwuenschter maternaler Begleitwirkungen , der Sectiorate und im fetal outcome " . " Bei reifer Zervix erwiesen sich das 2 mg PGE2-Vaginalgel und die 3 mg PGE2-Vaginaltablette als aequieffektiv . Mit dem 2 mg PGE2-Vaginalgel steht eine effiziente Applikationsform fuer die Geburtseinleitung ab einem Bishop-Score > =3 zur Verfuegung .

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[ "umlsterm" ]

Effizienz, Geburtseinleitung, Muttermundsverhaeltnissen, Geburtseinleitung

PerinatalMedizin.80100081.ger.abstr_task2

Sentence: Im Rahmen einer prospektiven randomisierten Multicenterstudie wurde bei 796 Patientinnen die Effizienz der Geburtseinleitung mittels 2 mg PGE2-Vaginalgel vs. 0,5 mg Intrazervikalgel bei unreifer Zervix ( Bishop-Score 3-4 ) und von 2 mg PGE2-Vaginalgel vs. der 3 mg PGE2-Vaginaltablette bei reifer Zervix ( Bishop-Score 5-7 ) vergleichend untersucht . Bei unreifen Muttermundsverhaeltnissen wies das 2 mg PGE2-Vaginalgel hinsichtlich des Reifungseffekts , der medianen Induktionsgeburtsintervalle und der kumulativen Entbindungsraten/24 h signifikant bessere Ergebnisse auf als das Intrazervikalgel ; keine signifikanten Unterschiede ergaben sich in der Haeufigkeit uteriner Ueberstimulierungen , unerwuenschter maternaler Begleitwirkungen , der Sectiorate und im fetal outcome " . " Bei reifer Zervix erwiesen sich das 2 mg PGE2-Vaginalgel und die 3 mg PGE2-Vaginaltablette als aequieffektiv . Mit dem 2 mg PGE2-Vaginalgel steht eine effiziente Applikationsform fuer die Geburtseinleitung ab einem Bishop-Score > =3 zur Verfuegung . Instructions: please extract entity words from the input sentence

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Im Rahmen einer prospektiven randomisierten Multicenterstudie wurde bei 796 Patientinnen die Effizienz der Geburtseinleitung mittels 2 mg PGE2-Vaginalgel vs. 0,5 mg Intrazervikalgel bei unreifer Zervix ( Bishop-Score 3-4 ) und von 2 mg PGE2-Vaginalgel vs. der 3 mg PGE2-Vaginaltablette bei reifer Zervix ( Bishop-Score 5-7 ) vergleichend untersucht . Bei unreifen Muttermundsverhaeltnissen wies das 2 mg PGE2-Vaginalgel hinsichtlich des Reifungseffekts , der medianen Induktionsgeburtsintervalle und der kumulativen Entbindungsraten/24 h signifikant bessere Ergebnisse auf als das Intrazervikalgel ; keine signifikanten Unterschiede ergaben sich in der Haeufigkeit uteriner Ueberstimulierungen , unerwuenschter maternaler Begleitwirkungen , der Sectiorate und im fetal outcome " . " Bei reifer Zervix erwiesen sich das 2 mg PGE2-Vaginalgel und die 3 mg PGE2-Vaginaltablette als aequieffektiv . Mit dem 2 mg PGE2-Vaginalgel steht eine effiziente Applikationsform fuer die Geburtseinleitung ab einem Bishop-Score > =3 zur Verfuegung .

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[ "umlsterm" ]

cystitis is an umlsterm, toxic is an umlsterm, complication is an umlsterm, chemotherapy is an umlsterm, cyclophosphamide is an umlsterm, incidence is an umlsterm, bone marrow transplantation is an umlsterm, bladder is an umlsterm, hematuria is an umlsterm, clot is an umlsterm, bladder is an umlsterm, preventive measures is an umlsterm, Prevention is an umlsterm, incidence is an umlsterm, cystitis is an umlsterm, Treatment is an umlsterm, diuresis is an umlsterm, bladder is an umlsterm, irrigation is an umlsterm, cauterisation is an umlsterm, hemostyptic is an umlsterm, Embolisation is an umlsterm, vessels is an umlsterm, open is an umlsterm, surgery is an umlsterm

DerUrologeA.80370516.eng.abstr_task0

Sentence: Hemorrhagic cystitis is a well known toxic and often life-threatening complication from high-dose chemotherapy with cyclophosphamide . The incidence is particularly high after allogeneic bone marrow transplantation . The morphologic bladder wall changes are associated with gross hematuria , clot formation in the bladder and problems to control the bleeding in up to 70 % without preventive measures . Prevention is routinely done and can reduce but not obviate the incidence of hemorrhagic cystitis . Treatment is initiated by forced diuresis and continous bladder irrigation . When necessary endoscopic cauterisation of bleeding mucosal areas is combined with the instillation of hemostyptic agents . Embolisation of the pelvic vessels or open surgery to control the bleeding is indicated in selected cases in a life-threatening situation . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Hemorrhagic cystitis is a well known toxic and often life-threatening complication from high-dose chemotherapy with cyclophosphamide . The incidence is particularly high after allogeneic bone marrow transplantation . The morphologic bladder wall changes are associated with gross hematuria , clot formation in the bladder and problems to control the bleeding in up to 70 % without preventive measures . Prevention is routinely done and can reduce but not obviate the incidence of hemorrhagic cystitis . Treatment is initiated by forced diuresis and continous bladder irrigation . When necessary endoscopic cauterisation of bleeding mucosal areas is combined with the instillation of hemostyptic agents . Embolisation of the pelvic vessels or open surgery to control the bleeding is indicated in selected cases in a life-threatening situation .

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[ "umlsterm" ]

cystitis is an umlsterm, toxic is an umlsterm, complication is an umlsterm, chemotherapy is an umlsterm, cyclophosphamide is an umlsterm, incidence is an umlsterm, bone marrow transplantation is an umlsterm, bladder is an umlsterm, hematuria is an umlsterm, clot is an umlsterm, bladder is an umlsterm, preventive measures is an umlsterm, Prevention is an umlsterm, incidence is an umlsterm, cystitis is an umlsterm, Treatment is an umlsterm, diuresis is an umlsterm, bladder is an umlsterm, irrigation is an umlsterm, cauterisation is an umlsterm, hemostyptic is an umlsterm, Embolisation is an umlsterm, vessels is an umlsterm, open is an umlsterm, surgery is an umlsterm

DerUrologeA.80370516.eng.abstr_task1

Sentence: Hemorrhagic cystitis is a well known toxic and often life-threatening complication from high-dose chemotherapy with cyclophosphamide . The incidence is particularly high after allogeneic bone marrow transplantation . The morphologic bladder wall changes are associated with gross hematuria , clot formation in the bladder and problems to control the bleeding in up to 70 % without preventive measures . Prevention is routinely done and can reduce but not obviate the incidence of hemorrhagic cystitis . Treatment is initiated by forced diuresis and continous bladder irrigation . When necessary endoscopic cauterisation of bleeding mucosal areas is combined with the instillation of hemostyptic agents . Embolisation of the pelvic vessels or open surgery to control the bleeding is indicated in selected cases in a life-threatening situation . Instructions: please typing these entity words according to sentence: cystitis, toxic, complication, chemotherapy, cyclophosphamide, incidence, bone marrow transplantation, bladder, hematuria, clot, bladder, preventive measures, Prevention, incidence, cystitis, Treatment, diuresis, bladder, irrigation, cauterisation, hemostyptic, Embolisation, vessels, open, surgery Options: umlsterm

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Hemorrhagic cystitis is a well known toxic and often life-threatening complication from high-dose chemotherapy with cyclophosphamide . The incidence is particularly high after allogeneic bone marrow transplantation . The morphologic bladder wall changes are associated with gross hematuria , clot formation in the bladder and problems to control the bleeding in up to 70 % without preventive measures . Prevention is routinely done and can reduce but not obviate the incidence of hemorrhagic cystitis . Treatment is initiated by forced diuresis and continous bladder irrigation . When necessary endoscopic cauterisation of bleeding mucosal areas is combined with the instillation of hemostyptic agents . Embolisation of the pelvic vessels or open surgery to control the bleeding is indicated in selected cases in a life-threatening situation .

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[ "umlsterm" ]

cystitis, toxic, complication, chemotherapy, cyclophosphamide, incidence, bone marrow transplantation, bladder, hematuria, clot, bladder, preventive measures, Prevention, incidence, cystitis, Treatment, diuresis, bladder, irrigation, cauterisation, hemostyptic, Embolisation, vessels, open, surgery

DerUrologeA.80370516.eng.abstr_task2

Sentence: Hemorrhagic cystitis is a well known toxic and often life-threatening complication from high-dose chemotherapy with cyclophosphamide . The incidence is particularly high after allogeneic bone marrow transplantation . The morphologic bladder wall changes are associated with gross hematuria , clot formation in the bladder and problems to control the bleeding in up to 70 % without preventive measures . Prevention is routinely done and can reduce but not obviate the incidence of hemorrhagic cystitis . Treatment is initiated by forced diuresis and continous bladder irrigation . When necessary endoscopic cauterisation of bleeding mucosal areas is combined with the instillation of hemostyptic agents . Embolisation of the pelvic vessels or open surgery to control the bleeding is indicated in selected cases in a life-threatening situation . Instructions: please extract entity words from the input sentence

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Hemorrhagic cystitis is a well known toxic and often life-threatening complication from high-dose chemotherapy with cyclophosphamide . The incidence is particularly high after allogeneic bone marrow transplantation . The morphologic bladder wall changes are associated with gross hematuria , clot formation in the bladder and problems to control the bleeding in up to 70 % without preventive measures . Prevention is routinely done and can reduce but not obviate the incidence of hemorrhagic cystitis . Treatment is initiated by forced diuresis and continous bladder irrigation . When necessary endoscopic cauterisation of bleeding mucosal areas is combined with the instillation of hemostyptic agents . Embolisation of the pelvic vessels or open surgery to control the bleeding is indicated in selected cases in a life-threatening situation .

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[ "umlsterm" ]

ketoprofen is a DRUG, Orudis is a BRAND, ketoprofen is a DRUG, Antacids is a GROUP, magnesium hydroxide is a DRUG, aluminum hydroxide is a DRUG, ketoprofen is a DRUG, Orudis is a BRAND, Aspirin is a BRAND, Ketoprofen is a DRUG, aspirin is a BRAND, aspirin is a BRAND, ketoprofen is a DRUG, ketoprofen is a DRUG, aspirin is a BRAND, aspirin is a BRAND, aspirin is a BRAND, ketoprofen is a DRUG, Diuretic is a GROUP, Hydrochlorothiazide is a DRUG, ketoprofen is a DRUG, hydrochlorothiazide is a DRUG, diuretics is a GROUP, Digoxin is a DRUG, ketoprofen is a DRUG, digoxin is a DRUG, ketoprofen is a DRUG, digoxin is a DRUG, Warfarin is a DRUG, ketoprofen is a DRUG, warfarin is a DRUG, warfarin is a DRUG, ketoprofen is a DRUG, ketoprofen is a DRUG, ketoprofen is a DRUG, warfarin is a DRUG, Probenecid is a DRUG, Probenecid is a DRUG, ketoprofen is a DRUG, ketoprofen is a DRUG, ketoprofen is a DRUG, probenecid is a DRUG, Methotrexate is a DRUG, Ketoprofen is a DRUG, NSAIDs is a GROUP, methotrexate is a DRUG, Lithium is a DRUG, Nonsteroidal anti - inflammatory agents is a GROUP, lithium is a DRUG, lithium is a DRUG, ketoprofen is a DRUG, lithium is a DRUG, Ketoprofen is a DRUG

Ketoprofen_ddi_task0

Sentence: The following drug interactions were studied with ketoprofen doses of 200 mg/day. The possibility of increased interaction should be kept in mind when Orudis doses greater than 50 mg as a single dose or 200 mg of ketoprofen per day are used concomitantly with highly bound drugs. 1. Antacids: Concomitant administration of magnesium hydroxide and aluminum hydroxide does not interfere with the rate or extent of the absorption of ketoprofen administered as Orudis. 2. Aspirin: Ketoprofen does not alter aspirin absorption; however, in a study of 12 normal subjects, concurrent administration of aspirin decreased ketoprofen protein binding and increased ketoprofen plasma clearance from 0.07 L/kg/h without aspirin to 0.11 L/kg/h with aspirin. The clinical significance of these changes has not been adequately studied. Therefore, concurrent use of aspirin and ketoprofen is not recommended. 3. Diuretic: Hydrochlorothiazide, given concomitantly with ketoprofen, produces a reduction in urinary potassium and chloride excretion compared to hydrochlorothiazide alone. Patients taking diuretics are at a greater risk of developing renal failure secondary to a decrease in renal blood flow caused by prostaglandin inhibition. 4. Digoxin: In a study in 12 patients with congestive heart failure where ketoprofen and digoxin were concomitantly administered, ketoprofen did not alter the serum levels of digoxin. 5. Warfarin: In a short-term controlled study in 14 normal volunteers, ketoprofen did not significantly interfere with the effect of warfarin on prothrombin time. Bleeding from a number of sites may be a complication of warfarin treatment and GI bleeding a complication of ketoprofen treatment. Because prostaglandina play an important role in hemostasis and ketoprofen has an effect on platelet function as well, concurent therapy with ketoprofen and warfarin requires close monitoring of patients on both drugs. 6. Probenecid: Probenecid increases both free and bound ketoprofen by reducing the plasma clearance of ketoprofen to about one-third, as well as decreasing its protein binding. Therefore, the combination of ketoprofen and probenecid is not recommended. 7. Methotrexate: Ketoprofen, like other NSAIDs, may cause changes in the elimination of methotrexate leading to elevated serum levels of the drug and increased toxicity. 8. Lithium: Nonsteroidal anti-inflammatory agents have been reported to increase steadystate plasma lithium levels. It is recommended that plasma lithium levels be monitored when ketoprofen is coadministered with lithium. DRUG/LABORATORY TEST INTERACTIONS: EFFECT ON BLOOD COAGULATION Ketoprofen decreases platelet adhesion and aggregation. Therefore, it can prolong bleeding time by approximately 3 to 4 minutes from baseline values. There is no significant change in platelet count, prothrombin time, partial thromboplastin time, or thrombin time. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GROUP, BRAND, DRUG

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The following drug interactions were studied with ketoprofen doses of 200 mg/day. The possibility of increased interaction should be kept in mind when Orudis doses greater than 50 mg as a single dose or 200 mg of ketoprofen per day are used concomitantly with highly bound drugs. 1. Antacids: Concomitant administration of magnesium hydroxide and aluminum hydroxide does not interfere with the rate or extent of the absorption of ketoprofen administered as Orudis. 2. Aspirin: Ketoprofen does not alter aspirin absorption; however, in a study of 12 normal subjects, concurrent administration of aspirin decreased ketoprofen protein binding and increased ketoprofen plasma clearance from 0.07 L/kg/h without aspirin to 0.11 L/kg/h with aspirin. The clinical significance of these changes has not been adequately studied. Therefore, concurrent use of aspirin and ketoprofen is not recommended. 3. Diuretic: Hydrochlorothiazide, given concomitantly with ketoprofen, produces a reduction in urinary potassium and chloride excretion compared to hydrochlorothiazide alone. Patients taking diuretics are at a greater risk of developing renal failure secondary to a decrease in renal blood flow caused by prostaglandin inhibition. 4. Digoxin: In a study in 12 patients with congestive heart failure where ketoprofen and digoxin were concomitantly administered, ketoprofen did not alter the serum levels of digoxin. 5. Warfarin: In a short-term controlled study in 14 normal volunteers, ketoprofen did not significantly interfere with the effect of warfarin on prothrombin time. Bleeding from a number of sites may be a complication of warfarin treatment and GI bleeding a complication of ketoprofen treatment. Because prostaglandina play an important role in hemostasis and ketoprofen has an effect on platelet function as well, concurent therapy with ketoprofen and warfarin requires close monitoring of patients on both drugs. 6. Probenecid: Probenecid increases both free and bound ketoprofen by reducing the plasma clearance of ketoprofen to about one-third, as well as decreasing its protein binding. Therefore, the combination of ketoprofen and probenecid is not recommended. 7. Methotrexate: Ketoprofen, like other NSAIDs, may cause changes in the elimination of methotrexate leading to elevated serum levels of the drug and increased toxicity. 8. Lithium: Nonsteroidal anti-inflammatory agents have been reported to increase steadystate plasma lithium levels. It is recommended that plasma lithium levels be monitored when ketoprofen is coadministered with lithium. DRUG/LABORATORY TEST INTERACTIONS: EFFECT ON BLOOD COAGULATION Ketoprofen decreases platelet adhesion and aggregation. Therefore, it can prolong bleeding time by approximately 3 to 4 minutes from baseline values. There is no significant change in platelet count, prothrombin time, partial thromboplastin time, or thrombin time.

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[ "GROUP", "DRUG", "BRAND" ]

ketoprofen is a DRUG, Orudis is a BRAND, ketoprofen is a DRUG, Antacids is a GROUP, magnesium hydroxide is a DRUG, aluminum hydroxide is a DRUG, ketoprofen is a DRUG, Orudis is a BRAND, Aspirin is a BRAND, Ketoprofen is a DRUG, aspirin is a BRAND, aspirin is a BRAND, ketoprofen is a DRUG, ketoprofen is a DRUG, aspirin is a BRAND, aspirin is a BRAND, aspirin is a BRAND, ketoprofen is a DRUG, Diuretic is a GROUP, Hydrochlorothiazide is a DRUG, ketoprofen is a DRUG, hydrochlorothiazide is a DRUG, diuretics is a GROUP, Digoxin is a DRUG, ketoprofen is a DRUG, digoxin is a DRUG, ketoprofen is a DRUG, digoxin is a DRUG, Warfarin is a DRUG, ketoprofen is a DRUG, warfarin is a DRUG, warfarin is a DRUG, ketoprofen is a DRUG, ketoprofen is a DRUG, ketoprofen is a DRUG, warfarin is a DRUG, Probenecid is a DRUG, Probenecid is a DRUG, ketoprofen is a DRUG, ketoprofen is a DRUG, ketoprofen is a DRUG, probenecid is a DRUG, Methotrexate is a DRUG, Ketoprofen is a DRUG, NSAIDs is a GROUP, methotrexate is a DRUG, Lithium is a DRUG, Nonsteroidal anti - inflammatory agents is a GROUP, lithium is a DRUG, lithium is a DRUG, ketoprofen is a DRUG, lithium is a DRUG, Ketoprofen is a DRUG

Ketoprofen_ddi_task1

Sentence: The following drug interactions were studied with ketoprofen doses of 200 mg/day. The possibility of increased interaction should be kept in mind when Orudis doses greater than 50 mg as a single dose or 200 mg of ketoprofen per day are used concomitantly with highly bound drugs. 1. Antacids: Concomitant administration of magnesium hydroxide and aluminum hydroxide does not interfere with the rate or extent of the absorption of ketoprofen administered as Orudis. 2. Aspirin: Ketoprofen does not alter aspirin absorption; however, in a study of 12 normal subjects, concurrent administration of aspirin decreased ketoprofen protein binding and increased ketoprofen plasma clearance from 0.07 L/kg/h without aspirin to 0.11 L/kg/h with aspirin. The clinical significance of these changes has not been adequately studied. Therefore, concurrent use of aspirin and ketoprofen is not recommended. 3. Diuretic: Hydrochlorothiazide, given concomitantly with ketoprofen, produces a reduction in urinary potassium and chloride excretion compared to hydrochlorothiazide alone. Patients taking diuretics are at a greater risk of developing renal failure secondary to a decrease in renal blood flow caused by prostaglandin inhibition. 4. Digoxin: In a study in 12 patients with congestive heart failure where ketoprofen and digoxin were concomitantly administered, ketoprofen did not alter the serum levels of digoxin. 5. Warfarin: In a short-term controlled study in 14 normal volunteers, ketoprofen did not significantly interfere with the effect of warfarin on prothrombin time. Bleeding from a number of sites may be a complication of warfarin treatment and GI bleeding a complication of ketoprofen treatment. Because prostaglandina play an important role in hemostasis and ketoprofen has an effect on platelet function as well, concurent therapy with ketoprofen and warfarin requires close monitoring of patients on both drugs. 6. Probenecid: Probenecid increases both free and bound ketoprofen by reducing the plasma clearance of ketoprofen to about one-third, as well as decreasing its protein binding. Therefore, the combination of ketoprofen and probenecid is not recommended. 7. Methotrexate: Ketoprofen, like other NSAIDs, may cause changes in the elimination of methotrexate leading to elevated serum levels of the drug and increased toxicity. 8. Lithium: Nonsteroidal anti-inflammatory agents have been reported to increase steadystate plasma lithium levels. It is recommended that plasma lithium levels be monitored when ketoprofen is coadministered with lithium. DRUG/LABORATORY TEST INTERACTIONS: EFFECT ON BLOOD COAGULATION Ketoprofen decreases platelet adhesion and aggregation. Therefore, it can prolong bleeding time by approximately 3 to 4 minutes from baseline values. There is no significant change in platelet count, prothrombin time, partial thromboplastin time, or thrombin time. Instructions: please typing these entity words according to sentence: ketoprofen, Orudis, ketoprofen, Antacids, magnesium hydroxide, aluminum hydroxide, ketoprofen, Orudis, Aspirin, Ketoprofen, aspirin, aspirin, ketoprofen, ketoprofen, aspirin, aspirin, aspirin, ketoprofen, Diuretic, Hydrochlorothiazide, ketoprofen, hydrochlorothiazide, diuretics, Digoxin, ketoprofen, digoxin, ketoprofen, digoxin, Warfarin, ketoprofen, warfarin, warfarin, ketoprofen, ketoprofen, ketoprofen, warfarin, Probenecid, Probenecid, ketoprofen, ketoprofen, ketoprofen, probenecid, Methotrexate, Ketoprofen, NSAIDs, methotrexate, Lithium, Nonsteroidal anti - inflammatory agents, lithium, lithium, ketoprofen, lithium, Ketoprofen Options: GROUP, BRAND, DRUG

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The following drug interactions were studied with ketoprofen doses of 200 mg/day. The possibility of increased interaction should be kept in mind when Orudis doses greater than 50 mg as a single dose or 200 mg of ketoprofen per day are used concomitantly with highly bound drugs. 1. Antacids: Concomitant administration of magnesium hydroxide and aluminum hydroxide does not interfere with the rate or extent of the absorption of ketoprofen administered as Orudis. 2. Aspirin: Ketoprofen does not alter aspirin absorption; however, in a study of 12 normal subjects, concurrent administration of aspirin decreased ketoprofen protein binding and increased ketoprofen plasma clearance from 0.07 L/kg/h without aspirin to 0.11 L/kg/h with aspirin. The clinical significance of these changes has not been adequately studied. Therefore, concurrent use of aspirin and ketoprofen is not recommended. 3. Diuretic: Hydrochlorothiazide, given concomitantly with ketoprofen, produces a reduction in urinary potassium and chloride excretion compared to hydrochlorothiazide alone. Patients taking diuretics are at a greater risk of developing renal failure secondary to a decrease in renal blood flow caused by prostaglandin inhibition. 4. Digoxin: In a study in 12 patients with congestive heart failure where ketoprofen and digoxin were concomitantly administered, ketoprofen did not alter the serum levels of digoxin. 5. Warfarin: In a short-term controlled study in 14 normal volunteers, ketoprofen did not significantly interfere with the effect of warfarin on prothrombin time. Bleeding from a number of sites may be a complication of warfarin treatment and GI bleeding a complication of ketoprofen treatment. Because prostaglandina play an important role in hemostasis and ketoprofen has an effect on platelet function as well, concurent therapy with ketoprofen and warfarin requires close monitoring of patients on both drugs. 6. Probenecid: Probenecid increases both free and bound ketoprofen by reducing the plasma clearance of ketoprofen to about one-third, as well as decreasing its protein binding. Therefore, the combination of ketoprofen and probenecid is not recommended. 7. Methotrexate: Ketoprofen, like other NSAIDs, may cause changes in the elimination of methotrexate leading to elevated serum levels of the drug and increased toxicity. 8. Lithium: Nonsteroidal anti-inflammatory agents have been reported to increase steadystate plasma lithium levels. It is recommended that plasma lithium levels be monitored when ketoprofen is coadministered with lithium. DRUG/LABORATORY TEST INTERACTIONS: EFFECT ON BLOOD COAGULATION Ketoprofen decreases platelet adhesion and aggregation. Therefore, it can prolong bleeding time by approximately 3 to 4 minutes from baseline values. There is no significant change in platelet count, prothrombin time, partial thromboplastin time, or thrombin time.

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[ "GROUP", "DRUG", "BRAND" ]

ketoprofen, Orudis, ketoprofen, Antacids, magnesium hydroxide, aluminum hydroxide, ketoprofen, Orudis, Aspirin, Ketoprofen, aspirin, aspirin, ketoprofen, ketoprofen, aspirin, aspirin, aspirin, ketoprofen, Diuretic, Hydrochlorothiazide, ketoprofen, hydrochlorothiazide, diuretics, Digoxin, ketoprofen, digoxin, ketoprofen, digoxin, Warfarin, ketoprofen, warfarin, warfarin, ketoprofen, ketoprofen, ketoprofen, warfarin, Probenecid, Probenecid, ketoprofen, ketoprofen, ketoprofen, probenecid, Methotrexate, Ketoprofen, NSAIDs, methotrexate, Lithium, Nonsteroidal anti - inflammatory agents, lithium, lithium, ketoprofen, lithium, Ketoprofen

Ketoprofen_ddi_task2

Sentence: The following drug interactions were studied with ketoprofen doses of 200 mg/day. The possibility of increased interaction should be kept in mind when Orudis doses greater than 50 mg as a single dose or 200 mg of ketoprofen per day are used concomitantly with highly bound drugs. 1. Antacids: Concomitant administration of magnesium hydroxide and aluminum hydroxide does not interfere with the rate or extent of the absorption of ketoprofen administered as Orudis. 2. Aspirin: Ketoprofen does not alter aspirin absorption; however, in a study of 12 normal subjects, concurrent administration of aspirin decreased ketoprofen protein binding and increased ketoprofen plasma clearance from 0.07 L/kg/h without aspirin to 0.11 L/kg/h with aspirin. The clinical significance of these changes has not been adequately studied. Therefore, concurrent use of aspirin and ketoprofen is not recommended. 3. Diuretic: Hydrochlorothiazide, given concomitantly with ketoprofen, produces a reduction in urinary potassium and chloride excretion compared to hydrochlorothiazide alone. Patients taking diuretics are at a greater risk of developing renal failure secondary to a decrease in renal blood flow caused by prostaglandin inhibition. 4. Digoxin: In a study in 12 patients with congestive heart failure where ketoprofen and digoxin were concomitantly administered, ketoprofen did not alter the serum levels of digoxin. 5. Warfarin: In a short-term controlled study in 14 normal volunteers, ketoprofen did not significantly interfere with the effect of warfarin on prothrombin time. Bleeding from a number of sites may be a complication of warfarin treatment and GI bleeding a complication of ketoprofen treatment. Because prostaglandina play an important role in hemostasis and ketoprofen has an effect on platelet function as well, concurent therapy with ketoprofen and warfarin requires close monitoring of patients on both drugs. 6. Probenecid: Probenecid increases both free and bound ketoprofen by reducing the plasma clearance of ketoprofen to about one-third, as well as decreasing its protein binding. Therefore, the combination of ketoprofen and probenecid is not recommended. 7. Methotrexate: Ketoprofen, like other NSAIDs, may cause changes in the elimination of methotrexate leading to elevated serum levels of the drug and increased toxicity. 8. Lithium: Nonsteroidal anti-inflammatory agents have been reported to increase steadystate plasma lithium levels. It is recommended that plasma lithium levels be monitored when ketoprofen is coadministered with lithium. DRUG/LABORATORY TEST INTERACTIONS: EFFECT ON BLOOD COAGULATION Ketoprofen decreases platelet adhesion and aggregation. Therefore, it can prolong bleeding time by approximately 3 to 4 minutes from baseline values. There is no significant change in platelet count, prothrombin time, partial thromboplastin time, or thrombin time. Instructions: please extract entity words from the input sentence

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The following drug interactions were studied with ketoprofen doses of 200 mg/day. The possibility of increased interaction should be kept in mind when Orudis doses greater than 50 mg as a single dose or 200 mg of ketoprofen per day are used concomitantly with highly bound drugs. 1. Antacids: Concomitant administration of magnesium hydroxide and aluminum hydroxide does not interfere with the rate or extent of the absorption of ketoprofen administered as Orudis. 2. Aspirin: Ketoprofen does not alter aspirin absorption; however, in a study of 12 normal subjects, concurrent administration of aspirin decreased ketoprofen protein binding and increased ketoprofen plasma clearance from 0.07 L/kg/h without aspirin to 0.11 L/kg/h with aspirin. The clinical significance of these changes has not been adequately studied. Therefore, concurrent use of aspirin and ketoprofen is not recommended. 3. Diuretic: Hydrochlorothiazide, given concomitantly with ketoprofen, produces a reduction in urinary potassium and chloride excretion compared to hydrochlorothiazide alone. Patients taking diuretics are at a greater risk of developing renal failure secondary to a decrease in renal blood flow caused by prostaglandin inhibition. 4. Digoxin: In a study in 12 patients with congestive heart failure where ketoprofen and digoxin were concomitantly administered, ketoprofen did not alter the serum levels of digoxin. 5. Warfarin: In a short-term controlled study in 14 normal volunteers, ketoprofen did not significantly interfere with the effect of warfarin on prothrombin time. Bleeding from a number of sites may be a complication of warfarin treatment and GI bleeding a complication of ketoprofen treatment. Because prostaglandina play an important role in hemostasis and ketoprofen has an effect on platelet function as well, concurent therapy with ketoprofen and warfarin requires close monitoring of patients on both drugs. 6. Probenecid: Probenecid increases both free and bound ketoprofen by reducing the plasma clearance of ketoprofen to about one-third, as well as decreasing its protein binding. Therefore, the combination of ketoprofen and probenecid is not recommended. 7. Methotrexate: Ketoprofen, like other NSAIDs, may cause changes in the elimination of methotrexate leading to elevated serum levels of the drug and increased toxicity. 8. Lithium: Nonsteroidal anti-inflammatory agents have been reported to increase steadystate plasma lithium levels. It is recommended that plasma lithium levels be monitored when ketoprofen is coadministered with lithium. DRUG/LABORATORY TEST INTERACTIONS: EFFECT ON BLOOD COAGULATION Ketoprofen decreases platelet adhesion and aggregation. Therefore, it can prolong bleeding time by approximately 3 to 4 minutes from baseline values. There is no significant change in platelet count, prothrombin time, partial thromboplastin time, or thrombin time.

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[ "GROUP", "DRUG", "BRAND" ]

FPLC is an assay, auxilin is a protein, Hsc70 is a protein, auxilin is a protein, Hsc70 is a protein

1.0alpha7.train.1121_task0

Sentence: However, it did not do so catalytically because FPLC showed that auxilin remained bound to polymerized Hsc70 at a 1:1 molar ratio of auxilin to Hsc70. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: assay, protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-assay", "O", "O", "B-protein", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "B-protein", "O", "B-protein", "O" ]

However, it did not do so catalytically because FPLC showed that auxilin remained bound to polymerized Hsc70 at a 1:1 molar ratio of auxilin to Hsc70.

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[ "protein", "assay" ]

FPLC is an assay, auxilin is a protein, Hsc70 is a protein, auxilin is a protein, Hsc70 is a protein

1.0alpha7.train.1121_task1

Sentence: However, it did not do so catalytically because FPLC showed that auxilin remained bound to polymerized Hsc70 at a 1:1 molar ratio of auxilin to Hsc70. Instructions: please typing these entity words according to sentence: FPLC, auxilin, Hsc70, auxilin, Hsc70 Options: assay, protein

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-assay", "O", "O", "B-protein", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "B-protein", "O", "B-protein", "O" ]

However, it did not do so catalytically because FPLC showed that auxilin remained bound to polymerized Hsc70 at a 1:1 molar ratio of auxilin to Hsc70.

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[ "protein", "assay" ]

FPLC, auxilin, Hsc70, auxilin, Hsc70

1.0alpha7.train.1121_task2

Sentence: However, it did not do so catalytically because FPLC showed that auxilin remained bound to polymerized Hsc70 at a 1:1 molar ratio of auxilin to Hsc70. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-assay", "O", "O", "B-protein", "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "B-protein", "O", "B-protein", "O" ]

However, it did not do so catalytically because FPLC showed that auxilin remained bound to polymerized Hsc70 at a 1:1 molar ratio of auxilin to Hsc70.

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[ "protein", "assay" ]

prevalence is an umlsterm, symptoms is an umlsterm, disorders is an umlsterm, patients is an umlsterm, differential diagnosis is an umlsterm, disorders is an umlsterm, symptoms is an umlsterm, psychotic is an umlsterm, secondary is an umlsterm, neurologic manifestations is an umlsterm, nervous is an umlsterm, infections is an umlsterm, lymphoma is an umlsterm, findings is an umlsterm, differential diagnosis is an umlsterm, identification is an umlsterm, psychiatric disorders is an umlsterm, Secondary is an umlsterm, neurologic manifestations is an umlsterm, psychosis is an umlsterm, brain is an umlsterm, imaging is an umlsterm, MRI is an umlsterm, analysis is an umlsterm, cerebrospinal fluid is an umlsterm, emergency situations is an umlsterm, law is an umlsterm, regulations is an umlsterm, patients is an umlsterm, case reports is an umlsterm

DerNervenarzt.00710404.eng.abstr_task0

Sentence: The prevalence of psychiatric symptoms and disorders in HIV-infected patients is high . The differential diagnosis includes psychoreactive disorders , acute psychiatric symptoms of an HIV-associated encephalopathy , and symptomatic psychotic illnesses due to secondary neurologic manifestations such as opportunistic central nervous infections and intracerebral lymphoma . Clinical aspects and psychopathological findings are not sufficient for differential diagnosis and identification of primarily psychiatric disorders . Secondary neurologic manifestations causing a symptomatic psychosis must be excluded as soon as possible by brain imaging ( CT , MRI ) and analysis of the cerebrospinal fluid . In emergency situations , however , German law imposes strict regulations , especially in the case of sectioned patients . These medical and medicolegal questions are illustrated by case reports and propositions for an effective strategy are made . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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The prevalence of psychiatric symptoms and disorders in HIV-infected patients is high . The differential diagnosis includes psychoreactive disorders , acute psychiatric symptoms of an HIV-associated encephalopathy , and symptomatic psychotic illnesses due to secondary neurologic manifestations such as opportunistic central nervous infections and intracerebral lymphoma . Clinical aspects and psychopathological findings are not sufficient for differential diagnosis and identification of primarily psychiatric disorders . Secondary neurologic manifestations causing a symptomatic psychosis must be excluded as soon as possible by brain imaging ( CT , MRI ) and analysis of the cerebrospinal fluid . In emergency situations , however , German law imposes strict regulations , especially in the case of sectioned patients . These medical and medicolegal questions are illustrated by case reports and propositions for an effective strategy are made .

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[ "umlsterm" ]

prevalence is an umlsterm, symptoms is an umlsterm, disorders is an umlsterm, patients is an umlsterm, differential diagnosis is an umlsterm, disorders is an umlsterm, symptoms is an umlsterm, psychotic is an umlsterm, secondary is an umlsterm, neurologic manifestations is an umlsterm, nervous is an umlsterm, infections is an umlsterm, lymphoma is an umlsterm, findings is an umlsterm, differential diagnosis is an umlsterm, identification is an umlsterm, psychiatric disorders is an umlsterm, Secondary is an umlsterm, neurologic manifestations is an umlsterm, psychosis is an umlsterm, brain is an umlsterm, imaging is an umlsterm, MRI is an umlsterm, analysis is an umlsterm, cerebrospinal fluid is an umlsterm, emergency situations is an umlsterm, law is an umlsterm, regulations is an umlsterm, patients is an umlsterm, case reports is an umlsterm

DerNervenarzt.00710404.eng.abstr_task1

Sentence: The prevalence of psychiatric symptoms and disorders in HIV-infected patients is high . The differential diagnosis includes psychoreactive disorders , acute psychiatric symptoms of an HIV-associated encephalopathy , and symptomatic psychotic illnesses due to secondary neurologic manifestations such as opportunistic central nervous infections and intracerebral lymphoma . Clinical aspects and psychopathological findings are not sufficient for differential diagnosis and identification of primarily psychiatric disorders . Secondary neurologic manifestations causing a symptomatic psychosis must be excluded as soon as possible by brain imaging ( CT , MRI ) and analysis of the cerebrospinal fluid . In emergency situations , however , German law imposes strict regulations , especially in the case of sectioned patients . These medical and medicolegal questions are illustrated by case reports and propositions for an effective strategy are made . Instructions: please typing these entity words according to sentence: prevalence, symptoms, disorders, patients, differential diagnosis, disorders, symptoms, psychotic, secondary, neurologic manifestations, nervous, infections, lymphoma, findings, differential diagnosis, identification, psychiatric disorders, Secondary, neurologic manifestations, psychosis, brain, imaging, MRI, analysis, cerebrospinal fluid, emergency situations, law, regulations, patients, case reports Options: umlsterm

[ "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

The prevalence of psychiatric symptoms and disorders in HIV-infected patients is high . The differential diagnosis includes psychoreactive disorders , acute psychiatric symptoms of an HIV-associated encephalopathy , and symptomatic psychotic illnesses due to secondary neurologic manifestations such as opportunistic central nervous infections and intracerebral lymphoma . Clinical aspects and psychopathological findings are not sufficient for differential diagnosis and identification of primarily psychiatric disorders . Secondary neurologic manifestations causing a symptomatic psychosis must be excluded as soon as possible by brain imaging ( CT , MRI ) and analysis of the cerebrospinal fluid . In emergency situations , however , German law imposes strict regulations , especially in the case of sectioned patients . These medical and medicolegal questions are illustrated by case reports and propositions for an effective strategy are made .

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[ "umlsterm" ]

prevalence, symptoms, disorders, patients, differential diagnosis, disorders, symptoms, psychotic, secondary, neurologic manifestations, nervous, infections, lymphoma, findings, differential diagnosis, identification, psychiatric disorders, Secondary, neurologic manifestations, psychosis, brain, imaging, MRI, analysis, cerebrospinal fluid, emergency situations, law, regulations, patients, case reports

DerNervenarzt.00710404.eng.abstr_task2

Sentence: The prevalence of psychiatric symptoms and disorders in HIV-infected patients is high . The differential diagnosis includes psychoreactive disorders , acute psychiatric symptoms of an HIV-associated encephalopathy , and symptomatic psychotic illnesses due to secondary neurologic manifestations such as opportunistic central nervous infections and intracerebral lymphoma . Clinical aspects and psychopathological findings are not sufficient for differential diagnosis and identification of primarily psychiatric disorders . Secondary neurologic manifestations causing a symptomatic psychosis must be excluded as soon as possible by brain imaging ( CT , MRI ) and analysis of the cerebrospinal fluid . In emergency situations , however , German law imposes strict regulations , especially in the case of sectioned patients . These medical and medicolegal questions are illustrated by case reports and propositions for an effective strategy are made . Instructions: please extract entity words from the input sentence

[ "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

The prevalence of psychiatric symptoms and disorders in HIV-infected patients is high . The differential diagnosis includes psychoreactive disorders , acute psychiatric symptoms of an HIV-associated encephalopathy , and symptomatic psychotic illnesses due to secondary neurologic manifestations such as opportunistic central nervous infections and intracerebral lymphoma . Clinical aspects and psychopathological findings are not sufficient for differential diagnosis and identification of primarily psychiatric disorders . Secondary neurologic manifestations causing a symptomatic psychosis must be excluded as soon as possible by brain imaging ( CT , MRI ) and analysis of the cerebrospinal fluid . In emergency situations , however , German law imposes strict regulations , especially in the case of sectioned patients . These medical and medicolegal questions are illustrated by case reports and propositions for an effective strategy are made .

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[ "umlsterm" ]

Bronchial carcinoma is a Participant_Condition, quality of survival is a Outcome_Mortality, Forty - eight is a Participant_Sample-size, bronchial carcinoma is a Participant_Condition, radiotherapy is a Intervention_Physical, chemotherapy ( cyclophosphamide ) is a Intervention_Pharmacological, placebo is a Intervention_Control, survival time is a Outcome_Mortality, median survival time is a Outcome_Mortality, median total sum of vitagram points is a Outcome_Other, median sum of vitagram points is a Outcome_Other

74012_task0

Sentence: Bronchial carcinoma . II . Quantitative measurements of the quality of survival . A prospective randomized study of the result of therapy in inoperable patients with advanced disease . Forty-eight bronchial carcinoma patients in clinicoanatomical stage 4 of the disease ( advanced disease ) were randomly assigned to groups for radiotherapy , chemotherapy ( cyclophosphamide ) and placebo treatment , respectively . The results were assessed by the survival time and quality of survival . The median survival time was 4.7 months for radiotherapy , 4.7 months for cyclophosphamide and 1.7 months for placebo . The median total sum of vitagram points was 28.1 for radiotherapy , 20.7 for cyclophosphamide and 6.8 for placebo . When calculated per month , the median sum of vitagram points was 5.9 for radiotherapy , 5.7 for cyclophosphamide and 4.8 for placebo . Statistically the results give no reason to believe that placebo is better than radiotherapy , but it can not be excluded that radiotherapy patients could have a much longer survival . As for cyclophosphamide versus radiotherapy , the differences are to uncertain for any conclusion to be drawn . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Intervention_Physical, Participant_Condition, Outcome_Mortality, Intervention_Control, Participant_Sample-size, Outcome_Other

[ "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "O", "O", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Bronchial carcinoma . II . Quantitative measurements of the quality of survival . A prospective randomized study of the result of therapy in inoperable patients with advanced disease . Forty-eight bronchial carcinoma patients in clinicoanatomical stage 4 of the disease ( advanced disease ) were randomly assigned to groups for radiotherapy , chemotherapy ( cyclophosphamide ) and placebo treatment , respectively . The results were assessed by the survival time and quality of survival . The median survival time was 4.7 months for radiotherapy , 4.7 months for cyclophosphamide and 1.7 months for placebo . The median total sum of vitagram points was 28.1 for radiotherapy , 20.7 for cyclophosphamide and 6.8 for placebo . When calculated per month , the median sum of vitagram points was 5.9 for radiotherapy , 5.7 for cyclophosphamide and 4.8 for placebo . Statistically the results give no reason to believe that placebo is better than radiotherapy , but it can not be excluded that radiotherapy patients could have a much longer survival . As for cyclophosphamide versus radiotherapy , the differences are to uncertain for any conclusion to be drawn .

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[ "Outcome_Other", "Intervention_Pharmacological", "Outcome_Mortality", "Participant_Condition", "Intervention_Physical", "Participant_Sample-size", "Intervention_Control" ]

Bronchial carcinoma is a Participant_Condition, quality of survival is a Outcome_Mortality, Forty - eight is a Participant_Sample-size, bronchial carcinoma is a Participant_Condition, radiotherapy is a Intervention_Physical, chemotherapy ( cyclophosphamide ) is a Intervention_Pharmacological, placebo is a Intervention_Control, survival time is a Outcome_Mortality, median survival time is a Outcome_Mortality, median total sum of vitagram points is a Outcome_Other, median sum of vitagram points is a Outcome_Other

74012_task1

Sentence: Bronchial carcinoma . II . Quantitative measurements of the quality of survival . A prospective randomized study of the result of therapy in inoperable patients with advanced disease . Forty-eight bronchial carcinoma patients in clinicoanatomical stage 4 of the disease ( advanced disease ) were randomly assigned to groups for radiotherapy , chemotherapy ( cyclophosphamide ) and placebo treatment , respectively . The results were assessed by the survival time and quality of survival . The median survival time was 4.7 months for radiotherapy , 4.7 months for cyclophosphamide and 1.7 months for placebo . The median total sum of vitagram points was 28.1 for radiotherapy , 20.7 for cyclophosphamide and 6.8 for placebo . When calculated per month , the median sum of vitagram points was 5.9 for radiotherapy , 5.7 for cyclophosphamide and 4.8 for placebo . Statistically the results give no reason to believe that placebo is better than radiotherapy , but it can not be excluded that radiotherapy patients could have a much longer survival . As for cyclophosphamide versus radiotherapy , the differences are to uncertain for any conclusion to be drawn . Instructions: please typing these entity words according to sentence: Bronchial carcinoma, quality of survival, Forty - eight, bronchial carcinoma, radiotherapy, chemotherapy ( cyclophosphamide ), placebo, survival time, median survival time, median total sum of vitagram points, median sum of vitagram points Options: Intervention_Pharmacological, Intervention_Physical, Participant_Condition, Outcome_Mortality, Intervention_Control, Participant_Sample-size, Outcome_Other

[ "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "O", "O", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Bronchial carcinoma . II . Quantitative measurements of the quality of survival . A prospective randomized study of the result of therapy in inoperable patients with advanced disease . Forty-eight bronchial carcinoma patients in clinicoanatomical stage 4 of the disease ( advanced disease ) were randomly assigned to groups for radiotherapy , chemotherapy ( cyclophosphamide ) and placebo treatment , respectively . The results were assessed by the survival time and quality of survival . The median survival time was 4.7 months for radiotherapy , 4.7 months for cyclophosphamide and 1.7 months for placebo . The median total sum of vitagram points was 28.1 for radiotherapy , 20.7 for cyclophosphamide and 6.8 for placebo . When calculated per month , the median sum of vitagram points was 5.9 for radiotherapy , 5.7 for cyclophosphamide and 4.8 for placebo . Statistically the results give no reason to believe that placebo is better than radiotherapy , but it can not be excluded that radiotherapy patients could have a much longer survival . As for cyclophosphamide versus radiotherapy , the differences are to uncertain for any conclusion to be drawn .

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[ "Outcome_Other", "Intervention_Pharmacological", "Outcome_Mortality", "Participant_Condition", "Intervention_Physical", "Participant_Sample-size", "Intervention_Control" ]

Bronchial carcinoma, quality of survival, Forty - eight, bronchial carcinoma, radiotherapy, chemotherapy ( cyclophosphamide ), placebo, survival time, median survival time, median total sum of vitagram points, median sum of vitagram points

74012_task2

Sentence: Bronchial carcinoma . II . Quantitative measurements of the quality of survival . A prospective randomized study of the result of therapy in inoperable patients with advanced disease . Forty-eight bronchial carcinoma patients in clinicoanatomical stage 4 of the disease ( advanced disease ) were randomly assigned to groups for radiotherapy , chemotherapy ( cyclophosphamide ) and placebo treatment , respectively . The results were assessed by the survival time and quality of survival . The median survival time was 4.7 months for radiotherapy , 4.7 months for cyclophosphamide and 1.7 months for placebo . The median total sum of vitagram points was 28.1 for radiotherapy , 20.7 for cyclophosphamide and 6.8 for placebo . When calculated per month , the median sum of vitagram points was 5.9 for radiotherapy , 5.7 for cyclophosphamide and 4.8 for placebo . Statistically the results give no reason to believe that placebo is better than radiotherapy , but it can not be excluded that radiotherapy patients could have a much longer survival . As for cyclophosphamide versus radiotherapy , the differences are to uncertain for any conclusion to be drawn . Instructions: please extract entity words from the input sentence

[ "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "O", "O", "O", "B-Outcome_Mortality", "I-Outcome_Mortality", "I-Outcome_Mortality", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Bronchial carcinoma . II . Quantitative measurements of the quality of survival . A prospective randomized study of the result of therapy in inoperable patients with advanced disease . Forty-eight bronchial carcinoma patients in clinicoanatomical stage 4 of the disease ( advanced disease ) were randomly assigned to groups for radiotherapy , chemotherapy ( cyclophosphamide ) and placebo treatment , respectively . The results were assessed by the survival time and quality of survival . The median survival time was 4.7 months for radiotherapy , 4.7 months for cyclophosphamide and 1.7 months for placebo . The median total sum of vitagram points was 28.1 for radiotherapy , 20.7 for cyclophosphamide and 6.8 for placebo . When calculated per month , the median sum of vitagram points was 5.9 for radiotherapy , 5.7 for cyclophosphamide and 4.8 for placebo . Statistically the results give no reason to believe that placebo is better than radiotherapy , but it can not be excluded that radiotherapy patients could have a much longer survival . As for cyclophosphamide versus radiotherapy , the differences are to uncertain for any conclusion to be drawn .

[ "Bronchial", "carcinoma", ".", "II", ".", "Quantitative", "measurements", "of", "the", "quality", "of", "survival", ".", "A", "prospective", "randomized", "study", "of", "the", "result", "of", "therapy", "in", "inoperable", "patients", "with", "advanced", "disease", ".", "Forty", "-", "eight", "bronchial", "carcinoma", "patients", "in", "clinicoanatomical", "stage", "4", "of", "the", "disease", "(", "advanced", "disease", ")", "were", "randomly", "assigned", "to", "groups", "for", "radiotherapy", ",", "chemotherapy", "(", "cyclophosphamide", ")", "and", "placebo", "treatment", ",", "respectively", ".", "The", "results", "were", "assessed", "by", "the", "survival", "time", "and", "quality", "of", "survival", ".", "The", "median", "survival", "time", "was", "4.7", "months", "for", "radiotherapy", ",", "4.7", "months", "for", "cyclophosphamide", "and", "1.7", "months", "for", "placebo", ".", "The", "median", "total", "sum", "of", "vitagram", "points", "was", "28.1", "for", "radiotherapy", ",", "20.7", "for", "cyclophosphamide", "and", "6.8", "for", "placebo", ".", "When", "calculated", "per", "month", ",", "the", "median", "sum", "of", "vitagram", "points", "was", "5.9", "for", "radiotherapy", ",", "5.7", "for", "cyclophosphamide", "and", "4.8", "for", "placebo", ".", "Statistically", "the", "results", "give", "no", "reason", "to", "believe", "that", "placebo", "is", "better", "than", "radiotherapy", ",", "but", "it", "can", "not", "be", "excluded", "that", "radiotherapy", "patients", "could", "have", "a", "much", "longer", "survival", ".", "As", "for", "cyclophosphamide", "versus", "radiotherapy", ",", "the", "differences", "are", "to", "uncertain", "for", "any", "conclusion", "to", "be", "drawn", "." ]

[ "Outcome_Other", "Intervention_Pharmacological", "Outcome_Mortality", "Participant_Condition", "Intervention_Physical", "Participant_Sample-size", "Intervention_Control" ]

functional T - cell receptor signaling pathway is an other_name, p95vav activity is an other_name

583_task0

Sentence: A functional T-cell receptor signaling pathway is required for p95vav activity. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: other_name

[ "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "O", "O", "O", "B-other_name", "I-other_name", "O" ]

A functional T-cell receptor signaling pathway is required for p95vav activity.

[ "A", "functional", "T", "-", "cell", "receptor", "signaling", "pathway", "is", "required", "for", "p95vav", "activity", "." ]

[ "protein_domain_or_region", "(AND other_name other_name)", "other_name", "(AND cell_type cell_type)", "protein_family_or_group", "other_organic_compound", "atom", "protein_molecule", "", "protein_substructure", "cell_line", "amino_acid_monomer", "cell_type" ]

functional T - cell receptor signaling pathway is an other_name, p95vav activity is an other_name

583_task1

Sentence: A functional T-cell receptor signaling pathway is required for p95vav activity. Instructions: please typing these entity words according to sentence: functional T - cell receptor signaling pathway, p95vav activity Options: other_name

[ "O", "B-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "I-other_name", "O", "O", "O", "B-other_name", "I-other_name", "O" ]

A functional T-cell receptor signaling pathway is required for p95vav activity.

[ "A", "functional", "T", "-", "cell", "receptor", "signaling", "pathway", "is", "required", "for", "p95vav", "activity", "." ]

[ "protein_domain_or_region", "(AND other_name other_name)", "other_name", "(AND cell_type cell_type)", "protein_family_or_group", "other_organic_compound", "atom", "protein_molecule", "", "protein_substructure", "cell_line", "amino_acid_monomer", "cell_type" ]