donb-hf/secondary-screen-dose-response-curve-parameters

broad_id string	depmap_id string	ccle_name string	screen_id string	upper_limit int64	lower_limit float64	slope float64	r2 float64	auc float64	ec50 float64	ic50 float64	name string	moa string	target string	disease.area string	indication string	smiles string	phase string	passed_str_profiling bool	row_name string
BRD-K71847383-001-12-5	ACH-000288	BT549_BREAST	HTS002	1	1.810211	0.111243	-0.003031	1.302289	9.260129	null	cytarabine	ribonucleotide reductase inhibitor	POLA1, POLB, POLD1, POLE	hematologic malignancy	acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL)	Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1, Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1, Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1	Launched	true	ACH-000288
BRD-K71847383-001-12-5	ACH-000415	BICR6_UPPER_AERODIGESTIVE_TRACT	HTS002	1	1.409581	0.120752	-0.061802	1.169222	1.550463	null	cytarabine	ribonucleotide reductase inhibitor	POLA1, POLB, POLD1, POLE	hematologic malignancy	acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL)	Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1, Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1, Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1	Launched	true	ACH-000415
BRD-K71847383-001-12-5	ACH-000228	BICR31_UPPER_AERODIGESTIVE_TRACT	HTS002	1	1.982005	-0.164109	0.131114	1.369119	0.003036	null	cytarabine	ribonucleotide reductase inhibitor	POLA1, POLB, POLD1, POLE	hematologic malignancy	acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL)	Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1, Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1, Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1	Launched	true	ACH-000228
BRD-K71847383-001-12-5	ACH-000977	LNCAPCLONEFGC_PROSTATE	HTS002	1	1.176368	5.44413	-0.142784	1.088256	0.077814	null	cytarabine	ribonucleotide reductase inhibitor	POLA1, POLB, POLD1, POLE	hematologic malignancy	acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL)	Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1, Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1, Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1	Launched	true	ACH-000977
BRD-K71847383-001-12-5	ACH-000397	TEN_ENDOMETRIUM	HTS002	1	2.26404	-0.082945	0.010249	1.492828	0.000329	null	cytarabine	ribonucleotide reductase inhibitor	POLA1, POLB, POLD1, POLE	hematologic malignancy	acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL)	Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1, Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1, Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1	Launched	true	ACH-000397
BRD-K71847383-001-12-5	ACH-000565	RCM1_LARGE_INTESTINE	HTS002	1	1.590267	0.109949	-0.042492	1.302732	0.048366	null	cytarabine	ribonucleotide reductase inhibitor	POLA1, POLB, POLD1, POLE	hematologic malignancy	acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL)	Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1, Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1, Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1	Launched	true	ACH-000565
BRD-K71847383-001-12-5	ACH-000209	SNU1079_BILIARY_TRACT	HTS002	1	1.555816	0.12506	-0.095405	1.29347	0.031018	null	cytarabine	ribonucleotide reductase inhibitor	POLA1, POLB, POLD1, POLE	hematologic malignancy	acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL)	Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1, Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1, Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1	Launched	true	ACH-000209
BRD-K71847383-001-12-5	ACH-000927	BT474_BREAST	HTS002	1	1.595816	0.117463	0.035402	1.243364	1.988602	null	cytarabine	ribonucleotide reductase inhibitor	POLA1, POLB, POLD1, POLE	hematologic malignancy	acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL)	Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1, Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1, Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1	Launched	true	ACH-000927
BRD-A98990573-003-01-3	ACH-000879	MFE296_ENDOMETRIUM	HTS002	1	2.406651	-0.073609	-0.123828	1.718502	0.141302	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000879
BRD-A98990573-003-01-3	ACH-000320	PSN1_PANCREAS	HTS002	1	2.153169	0.01822	-0.015702	1.565786	0.611409	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000320
BRD-A98990573-003-01-3	ACH-001145	OC316_OVARY	HTS002	1	1.930698	-0.128307	0.013193	1.525007	0.621301	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-001145
BRD-A98990573-003-01-3	ACH-000873	KYSE270_OESOPHAGUS	HTS002	1	1.663819	0.09446	0.017444	1.333858	0.068841	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000873
BRD-A98990573-003-01-3	ACH-000855	KYSE150_OESOPHAGUS	HTS002	1	2.443731	0.035814	-0.07384	1.461459	119,125,404.206814	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000855
BRD-A98990573-003-01-3	ACH-000913	ESS1_ENDOMETRIUM	HTS002	1	1.986984	0.276565	0.206415	1.455895	0.147025	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000913
BRD-A98990573-003-01-3	ACH-000558	A172_CENTRAL_NERVOUS_SYSTEM	HTS002	1	2.393393	-0.198751	-0.162024	1.581816	0.012899	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000558
BRD-A98990573-003-01-3	ACH-000593	BC3C_URINARY_TRACT	HTS002	1	2.131649	0.0142	0.017346	1.544465	15.994651	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000593
BRD-A98990573-003-01-3	ACH-000488	TE11_OESOPHAGUS	HTS002	1	1.403471	-0.146593	0.056054	1.249404	2.389566	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000488
BRD-A98990573-003-01-3	ACH-000832	CAL27_UPPER_AERODIGESTIVE_TRACT	HTS002	1	1.806094	-0.136659	-0.006901	1.462856	0.753831	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000832
BRD-A98990573-003-01-3	ACH-000781	NCIH2023_LUNG	HTS002	1	2.116241	0.013514	-0.043877	1.562774	0.022735	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000781
BRD-A98990573-003-01-3	ACH-000833	RH30_SOFT_TISSUE	HTS002	1	1.704559	-0.009088	-0.044286	1.355226	0.492545	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000833
BRD-A98990573-003-01-3	ACH-000137	8MGBA_CENTRAL_NERVOUS_SYSTEM	HTS002	1	1.912906	0.080341	-0.114723	1.510014	0.004002	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000137
BRD-A98990573-003-01-3	ACH-000632	HS944T_SKIN	HTS002	1	1.808378	-0.002097	-0.205969	1.405029	0.567232	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000632
BRD-A98990573-003-01-3	ACH-000630	YD8_UPPER_AERODIGESTIVE_TRACT	HTS002	1	1.659657	0.212536	-0.070869	1.347965	0.044491	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000630
BRD-A98990573-003-01-3	ACH-000266	SNU213_PANCREAS	HTS002	1	2.197751	-0.07709	-0.101426	1.680144	2.812235	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000266
BRD-A98990573-003-01-3	ACH-000047	GCIY_STOMACH	HTS002	1	1.169463	-0.063424	-0.122913	1.0977	10.520899	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000047
BRD-A98990573-003-01-3	ACH-000273	SF539_CENTRAL_NERVOUS_SYSTEM	HTS002	1	1.781141	-0.17458	-0.010169	1.428111	0.251615	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000273
BRD-A98990573-003-01-3	ACH-000682	SNU1066_UPPER_AERODIGESTIVE_TRACT	HTS002	1	0.906513	0.253387	-0.001659	0.940251	0.006255	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000682
BRD-A98990573-003-01-3	ACH-000359	MG63_BONE	HTS002	1	0.678547	0.290458	-0.106625	0.753177	0.000707	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000359
BRD-A98990573-003-01-3	ACH-000846	FADU_UPPER_AERODIGESTIVE_TRACT	HTS002	1	0.687044	0.113647	0.01733	0.945489	92,317.295283	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000846
BRD-A98990573-003-01-3	ACH-000804	NB1_AUTONOMIC_GANGLIA	HTS002	1	1.03215	-0.193507	-0.043366	1.018095	0.31676	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000804
BRD-A98990573-003-01-3	ACH-000609	SF126_CENTRAL_NERVOUS_SYSTEM	HTS002	1	0.722635	-0.381214	-0.036432	0.8183	0.651099	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000609
BRD-A98990573-003-01-3	ACH-000974	SNGM_ENDOMETRIUM	HTS002	1	1.995466	-0.168702	-0.009664	1.500396	0.083533	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000974
BRD-A98990573-003-01-3	ACH-000987	MEWO_SKIN	HTS002	1	1.650375	0.375233	0.301196	1.303564	0.122256	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000987
BRD-A98990573-003-01-3	ACH-000787	LXF289_LUNG	HTS002	1	1.532402	0.858926	0.228983	1.255558	0.095433	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000787
BRD-A98990573-003-01-3	ACH-000561	TT_OESOPHAGUS	HTS002	1	1.274219	-0.017798	0.004438	1.158504	3,764,418.111465	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000561
BRD-A98990573-003-01-3	ACH-000212	CAL120_BREAST	HTS002	1	1.842452	0.128951	0.033742	1.405999	0.139407	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000212
BRD-A98990573-003-01-3	ACH-000753	JMSU1_URINARY_TRACT	HTS002	1	1.49449	-0.236912	0.022282	1.270752	0.190536	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000753
BRD-A98990573-003-01-3	ACH-000305	ECGI10_OESOPHAGUS	HTS002	1	1.61547	-0.052329	-0.029299	1.358002	43.970646	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000305
BRD-A98990573-003-01-3	ACH-000138	CFPAC1_PANCREAS	HTS002	1	1.753365	0.257979	0.130517	1.380023	0.072298	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000138
BRD-A98990573-003-01-3	ACH-000250	KMRC20_KIDNEY	HTS002	1	1.494624	0.395246	0.190654	1.209002	0.215924	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000250
BRD-A98990573-003-01-3	ACH-000856	CAL51_BREAST	HTS002	1	1.735025	-0.228678	0.10814	1.285053	0.008714	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000856
BRD-A98990573-003-01-3	ACH-000046	ACHN_KIDNEY	HTS002	1	2.014146	0.0271	-0.020242	1.465787	32.507875	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000046
BRD-A98990573-003-01-3	ACH-000878	HCC15_LUNG	HTS002	1	1.964366	0.135892	0.020902	1.235052	425.682928	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000878
BRD-A98990573-003-01-3	ACH-000766	NCIH1648_LUNG	HTS002	1	1.552756	0.044905	0.023289	1.263833	0.595469	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000766
BRD-A98990573-003-01-3	ACH-000014	HS294T_SKIN	HTS002	1	1.866487	-0.441467	0.082457	1.491065	0.177963	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000014
BRD-A98990573-003-01-3	ACH-000701	RMUGS_OVARY	HTS002	1	1.93928	-0.108778	0.062088	1.4956	0.221216	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000701
BRD-A98990573-003-01-3	ACH-000884	MDAMB435S_SKIN	HTS002	1	1.561581	-0.062436	-0.00177	1.511362	1,325,035,067,871,792	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000884
BRD-A98990573-003-01-3	ACH-000037	S117_SOFT_TISSUE	HTS002	1	2.610757	-0.322145	0.057094	1.353067	0.000771	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000037
BRD-A98990573-003-01-3	ACH-000502	TCCPAN2_PANCREAS	HTS002	1	1.791147	0.046662	-0.052582	1.445164	0.000344	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000502
BRD-A98990573-003-01-3	ACH-000886	NCIH2009_LUNG	HTS002	1	1.824982	-0.040267	0.016273	1.40362	0.02675	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000886
BRD-A98990573-003-01-3	ACH-000035	NCIH1650_LUNG	HTS002	1	1.275007	0.014939	-0.127125	1.13901	0.017995	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000035
BRD-A98990573-003-01-3	ACH-000661	WM1799_SKIN	HTS002	1	1.373218	0.176351	0.033827	1.191805	0.055892	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000661
BRD-A98990573-003-01-3	ACH-000391	MHHES1_BONE	HTS002	1	1.321053	-0.094279	-0.007156	1.150176	0.019392	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000391
BRD-A98990573-003-01-3	ACH-000843	HARA_LUNG	HTS002	1	1.976587	-0.10598	0.080794	1.457676	0.023278	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000843
BRD-A98990573-003-01-3	ACH-000711	JIMT1_BREAST	HTS002	1	1.948984	0.184036	0.071032	1.52785	0.021135	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000711
BRD-A98990573-003-01-3	ACH-000232	U251MG_CENTRAL_NERVOUS_SYSTEM	HTS002	1	1.542617	0.219233	0.156442	1.261488	0.112082	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000232
BRD-A98990573-003-01-3	ACH-000060	PANC1005_PANCREAS	HTS002	1	1.801116	0.105156	-0.010876	1.297048	13.271048	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000060
BRD-A98990573-003-01-3	ACH-000322	HT144_SKIN	HTS002	1	2.744352	0.163127	0.199069	1.879861	0.069734	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000322
BRD-A98990573-003-01-3	ACH-000736	SNU601_STOMACH	HTS002	1	1.354943	-0.272767	-0.153729	1.097497	0.001394	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000736
BRD-A98990573-003-01-3	ACH-000809	KYSE410_OESOPHAGUS	HTS002	1	1.745682	0.225432	0.22769	1.36529	0.09516	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000809
BRD-A98990573-003-01-3	ACH-000747	NCIH1703_LUNG	HTS002	1	1.930434	8.051284	0.358434	1.331938	0.313671	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000747
BRD-A98990573-003-01-3	ACH-000364	U2OS_BONE	HTS002	1	1.623598	-0.010964	-0.091907	1.340628	1,739,143.771505	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000364
BRD-A98990573-003-01-3	ACH-000679	OE19_OESOPHAGUS	HTS002	1	1.981374	0.064406	-0.099249	1.496815	0.052841	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000679
BRD-A98990573-003-01-3	ACH-000985	LS411N_LARGE_INTESTINE	HTS002	1	0.880762	1.193111	-0.100253	0.951954	0.2018	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000985
BRD-A98990573-003-01-3	ACH-000441	SH4_SKIN	HTS002	1	1.660765	-1.079061	0.253114	1.40478	0.236411	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000441
BRD-A98990573-003-01-3	ACH-001113	LC1SQSF_LUNG	HTS002	1	1.671028	-0.623007	0.292925	1.414209	0.277152	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-001113
BRD-A98990573-003-01-3	ACH-000620	JHH1_LIVER	HTS002	1	6.052251	-1.201168	0.02801	1.085837	0.000172	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000620
BRD-A98990573-003-01-3	ACH-000853	NCIH661_LUNG	HTS002	1	1.797602	0.127079	0.052302	1.374245	0.212531	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000853
BRD-A98990573-003-01-3	ACH-000102	GMS10_CENTRAL_NERVOUS_SYSTEM	HTS002	1	1.341286	0.008135	-0.015857	1.171228	0.033644	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000102
BRD-A98990573-003-01-3	ACH-000648	NCIH28_PLEURA	HTS002	1	2.670765	0.188381	0.080214	1.576709	2.930078	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000648
BRD-A98990573-003-01-3	ACH-001321	TT_THYROID	HTS002	1	1.600621	0.319511	0.229367	1.325862	0.04134	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-001321
BRD-A98990573-003-01-3	ACH-000279	EWS502_BONE	HTS002	1	1.392272	-0.116253	-0.144175	1.318358	29,553.560728	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000279
BRD-A98990573-003-01-3	ACH-000172	TM87_SOFT_TISSUE	HTS002	1	1.191382	0.018894	-0.123475	1.095645	0.082241	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000172
BRD-A98990573-003-01-3	ACH-001128	MON_SOFT_TISSUE	HTS002	1	2.837286	1.31773	0.351164	2.530067	0.002812	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-001128
BRD-A98990573-003-01-3	ACH-000437	SW1088_CENTRAL_NERVOUS_SYSTEM	HTS002	1	2.464921	-0.161799	0.021702	1.483223	0.00079	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000437
BRD-A98990573-003-01-3	ACH-000207	DETROIT562_UPPER_AERODIGESTIVE_TRACT	HTS002	1	2.28056	-0.229442	0.28321	1.603477	0.044971	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000207
BRD-A98990573-003-01-3	ACH-000260	SKNAS_AUTONOMIC_GANGLIA	HTS002	1	1.546904	-0.151411	-0.033138	1.293755	0.218017	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000260
BRD-A98990573-003-01-3	ACH-000019	MCF7_BREAST	HTS002	1	1.46547	-0.100758	-0.017226	1.302785	41.859975	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000019
BRD-A98990573-003-01-3	ACH-000582	COLO741_SKIN	HTS002	1	1.448067	-0.27547	-0.096245	1.379457	79.715214	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000582
BRD-A98990573-003-01-3	ACH-000990	HEC108_ENDOMETRIUM	HTS002	1	1.570831	-0.088779	-0.037785	1.476341	8,069,214.118125	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000990
BRD-A98990573-003-01-3	ACH-000592	TM31_CENTRAL_NERVOUS_SYSTEM	HTS002	1	1.369895	0.257976	-0.091276	1.250242	0.003161	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000592
BRD-A98990573-003-01-3	ACH-000368	SNU1105_CENTRAL_NERVOUS_SYSTEM	HTS002	1	1.494473	-0.146671	-0.066263	1.342403	24.62497	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000368
BRD-A98990573-003-01-3	ACH-000517	SNU410_PANCREAS	HTS002	1	2.405004	-0.306842	-0.271216	1.315484	0.00073	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000517
BRD-A98990573-003-01-3	ACH-000374	HCC1143_BREAST	HTS002	1	1.971707	-0.160977	0.131079	1.41006	0.010041	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000374
BRD-A98990573-003-01-3	ACH-000527	OVISE_OVARY	HTS002	1	1.663536	0.24615	-0.080177	1.479834	0.001039	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000527
BRD-A98990573-003-01-3	ACH-000091	OV56_OVARY	HTS002	1	1.298686	-0.17482	-0.14306	1.177357	0.778295	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000091
BRD-A98990573-003-01-3	ACH-000759	MDAMB175VII_BREAST	HTS002	1	1.010161	-0.128943	-0.129627	1.006279	3.668881	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000759
BRD-A98990573-003-01-3	ACH-000417	PANC0813_PANCREAS	HTS002	1	1.813245	0.270191	-0.044787	1.365034	0.185574	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000417
BRD-A98990573-003-01-3	ACH-000308	EFO21_OVARY	HTS002	1	1.413574	0.086931	-0.024889	1.224231	0.01085	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000308
BRD-A98990573-003-01-3	ACH-000991	SNU81_LARGE_INTESTINE	HTS002	1	1.966944	0.040441	-0.016903	1.22707	411,647,219,914.019	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000991
BRD-A98990573-003-01-3	ACH-000948	2313287_STOMACH	HTS002	1	1.177057	-0.502442	-0.090841	1.118802	0.594219	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000948
BRD-A98990573-003-01-3	ACH-000481	NCIH2170_LUNG	HTS002	1	1.87338	0.008744	-0.017357	1.443936	0.001754	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000481
BRD-A98990573-003-01-3	ACH-000771	BICR56_UPPER_AERODIGESTIVE_TRACT	HTS002	1	1.819329	-0.09418	0.07333	1.393692	0.033634	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000771
BRD-A98990573-003-01-3	ACH-000159	OSRC2_KIDNEY	HTS002	1	1.262509	0.147054	0.025325	1.116855	0.372107	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000159
BRD-A98990573-003-01-3	ACH-000929	NCIH2110_LUNG	HTS002	1	3.663559	0.881271	0.148348	1.129812	21.129337	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000929
BRD-A98990573-003-01-3	ACH-000118	HUPT3_PANCREAS	HTS002	1	1.794215	-0.358423	0.007789	1.397125	0.078149	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000118
BRD-A98990573-003-01-3	ACH-000482	RERFLCKJ_LUNG	HTS002	1	1.526195	-0.088525	-0.094492	1.184886	0.000069	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000482
BRD-A98990573-003-01-3	ACH-000352	HCC1428_BREAST	HTS002	1	1.507227	0.098268	-0.075063	1.313161	0.000548	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000352
BRD-A98990573-003-01-3	ACH-000235	PANC0403_PANCREAS	HTS002	1	1.894912	-0.030993	-0.148693	1.436389	0.015782	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000235
BRD-A98990573-003-01-3	ACH-000479	KNS81_CENTRAL_NERVOUS_SYSTEM	HTS002	1	2.48851	0.050826	-0.027301	1.494476	77,323.177171	null	epinastine	histamine receptor antagonist	ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7	ophthalmology	conjunctivitis	NC1=NCC2N1c1ccccc1Cc1ccccc21	Launched	true	ACH-000479

BRD-K71847383-001-12-5

ACH-000288

BT549_BREAST

HTS002

1

1.810211

0.111243

-0.003031

1.302289

9.260129

null

cytarabine

ribonucleotide reductase inhibitor

POLA1, POLB, POLD1, POLE

hematologic malignancy

acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL)

Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1, Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1, Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1

Launched

true

ACH-000288

BRD-K71847383-001-12-5

ACH-000415

BICR6_UPPER_AERODIGESTIVE_TRACT

HTS002

1

1.409581

0.120752

-0.061802

1.169222

1.550463

null

cytarabine

ribonucleotide reductase inhibitor

POLA1, POLB, POLD1, POLE

hematologic malignancy

acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL)

Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1, Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1, Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1

Launched

true

ACH-000415

BRD-K71847383-001-12-5

ACH-000228

BICR31_UPPER_AERODIGESTIVE_TRACT

HTS002

1

1.982005

-0.164109

0.131114

1.369119

0.003036

null

cytarabine

ribonucleotide reductase inhibitor

POLA1, POLB, POLD1, POLE

hematologic malignancy

acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL)

Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1, Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1, Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1

Launched

true

ACH-000228

BRD-K71847383-001-12-5

ACH-000977

LNCAPCLONEFGC_PROSTATE

HTS002

1

1.176368

5.44413

-0.142784

1.088256

0.077814

null

cytarabine

ribonucleotide reductase inhibitor

POLA1, POLB, POLD1, POLE

hematologic malignancy

acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL)

Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1, Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1, Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1

Launched

true

ACH-000977

BRD-K71847383-001-12-5

ACH-000397

TEN_ENDOMETRIUM

HTS002

1

2.26404

-0.082945

0.010249

1.492828

0.000329

null

cytarabine

ribonucleotide reductase inhibitor

POLA1, POLB, POLD1, POLE

hematologic malignancy

acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL)

Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1, Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1, Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1

Launched

true

ACH-000397

BRD-K71847383-001-12-5

ACH-000565

RCM1_LARGE_INTESTINE

HTS002

1

1.590267

0.109949

-0.042492

1.302732

0.048366

null

cytarabine

ribonucleotide reductase inhibitor

POLA1, POLB, POLD1, POLE

hematologic malignancy

acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL)

Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1, Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1, Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1

Launched

true

ACH-000565

BRD-K71847383-001-12-5

ACH-000209

SNU1079_BILIARY_TRACT

HTS002

1

1.555816

0.12506

-0.095405

1.29347

0.031018

null

cytarabine

ribonucleotide reductase inhibitor

POLA1, POLB, POLD1, POLE

hematologic malignancy

acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL)

Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1, Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1, Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1

Launched

true

ACH-000209

BRD-K71847383-001-12-5

ACH-000927

BT474_BREAST

HTS002

1

1.595816

0.117463

0.035402

1.243364

1.988602

null

cytarabine

ribonucleotide reductase inhibitor

POLA1, POLB, POLD1, POLE

hematologic malignancy

acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL)

Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1, Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1, Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1

Launched

true

ACH-000927

BRD-A98990573-003-01-3

ACH-000879

MFE296_ENDOMETRIUM

HTS002

1

2.406651

-0.073609

-0.123828

1.718502

0.141302

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000879

BRD-A98990573-003-01-3

ACH-000320

PSN1_PANCREAS

HTS002

1

2.153169

0.01822

-0.015702

1.565786

0.611409

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000320

BRD-A98990573-003-01-3

ACH-001145

OC316_OVARY

HTS002

1

1.930698

-0.128307

0.013193

1.525007

0.621301

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-001145

BRD-A98990573-003-01-3

ACH-000873

KYSE270_OESOPHAGUS

HTS002

1

1.663819

0.09446

0.017444

1.333858

0.068841

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000873

BRD-A98990573-003-01-3

ACH-000855

KYSE150_OESOPHAGUS

HTS002

1

2.443731

0.035814

-0.07384

1.461459

119,125,404.206814

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000855

BRD-A98990573-003-01-3

ACH-000913

ESS1_ENDOMETRIUM

HTS002

1

1.986984

0.276565

0.206415

1.455895

0.147025

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000913

BRD-A98990573-003-01-3

ACH-000558

A172_CENTRAL_NERVOUS_SYSTEM

HTS002

1

2.393393

-0.198751

-0.162024

1.581816

0.012899

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000558

BRD-A98990573-003-01-3

ACH-000593

BC3C_URINARY_TRACT

HTS002

1

2.131649

0.0142

0.017346

1.544465

15.994651

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000593

BRD-A98990573-003-01-3

ACH-000488

TE11_OESOPHAGUS

HTS002

1

1.403471

-0.146593

0.056054

1.249404

2.389566

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000488

BRD-A98990573-003-01-3

ACH-000832

CAL27_UPPER_AERODIGESTIVE_TRACT

HTS002

1

1.806094

-0.136659

-0.006901

1.462856

0.753831

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000832

BRD-A98990573-003-01-3

ACH-000781

NCIH2023_LUNG

HTS002

1

2.116241

0.013514

-0.043877

1.562774

0.022735

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000781

BRD-A98990573-003-01-3

ACH-000833

RH30_SOFT_TISSUE

HTS002

1

1.704559

-0.009088

-0.044286

1.355226

0.492545

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000833

BRD-A98990573-003-01-3

ACH-000137

8MGBA_CENTRAL_NERVOUS_SYSTEM

HTS002

1

1.912906

0.080341

-0.114723

1.510014

0.004002

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000137

BRD-A98990573-003-01-3

ACH-000632

HS944T_SKIN

HTS002

1

1.808378

-0.002097

-0.205969

1.405029

0.567232

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000632

BRD-A98990573-003-01-3

ACH-000630

YD8_UPPER_AERODIGESTIVE_TRACT

HTS002

1

1.659657

0.212536

-0.070869

1.347965

0.044491

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000630

BRD-A98990573-003-01-3

ACH-000266

SNU213_PANCREAS

HTS002

1

2.197751

-0.07709

-0.101426

1.680144

2.812235

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000266

BRD-A98990573-003-01-3

ACH-000047

GCIY_STOMACH

HTS002

1

1.169463

-0.063424

-0.122913

1.0977

10.520899

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000047

BRD-A98990573-003-01-3

ACH-000273

SF539_CENTRAL_NERVOUS_SYSTEM

HTS002

1

1.781141

-0.17458

-0.010169

1.428111

0.251615

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000273

BRD-A98990573-003-01-3

ACH-000682

SNU1066_UPPER_AERODIGESTIVE_TRACT

HTS002

1

0.906513

0.253387

-0.001659

0.940251

0.006255

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000682

BRD-A98990573-003-01-3

ACH-000359

MG63_BONE

HTS002

1

0.678547

0.290458

-0.106625

0.753177

0.000707

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000359

BRD-A98990573-003-01-3

ACH-000846

FADU_UPPER_AERODIGESTIVE_TRACT

HTS002

1

0.687044

0.113647

0.01733

0.945489

92,317.295283

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000846

BRD-A98990573-003-01-3

ACH-000804

NB1_AUTONOMIC_GANGLIA

HTS002

1

1.03215

-0.193507

-0.043366

1.018095

0.31676

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000804

BRD-A98990573-003-01-3

ACH-000609

SF126_CENTRAL_NERVOUS_SYSTEM

HTS002

1

0.722635

-0.381214

-0.036432

0.8183

0.651099

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000609

BRD-A98990573-003-01-3

ACH-000974

SNGM_ENDOMETRIUM

HTS002

1

1.995466

-0.168702

-0.009664

1.500396

0.083533

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000974

BRD-A98990573-003-01-3

ACH-000987

MEWO_SKIN

HTS002

1

1.650375

0.375233

0.301196

1.303564

0.122256

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000987

BRD-A98990573-003-01-3

ACH-000787

LXF289_LUNG

HTS002

1

1.532402

0.858926

0.228983

1.255558

0.095433

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000787

BRD-A98990573-003-01-3

ACH-000561

TT_OESOPHAGUS

HTS002

1

1.274219

-0.017798

0.004438

1.158504

3,764,418.111465

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000561

BRD-A98990573-003-01-3

ACH-000212

CAL120_BREAST

HTS002

1

1.842452

0.128951

0.033742

1.405999

0.139407

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000212

BRD-A98990573-003-01-3

ACH-000753

JMSU1_URINARY_TRACT

HTS002

1

1.49449

-0.236912

0.022282

1.270752

0.190536

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000753

BRD-A98990573-003-01-3

ACH-000305

ECGI10_OESOPHAGUS

HTS002

1

1.61547

-0.052329

-0.029299

1.358002

43.970646

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000305

BRD-A98990573-003-01-3

ACH-000138

CFPAC1_PANCREAS

HTS002

1

1.753365

0.257979

0.130517

1.380023

0.072298

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000138

BRD-A98990573-003-01-3

ACH-000250

KMRC20_KIDNEY

HTS002

1

1.494624

0.395246

0.190654

1.209002

0.215924

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000250

BRD-A98990573-003-01-3

ACH-000856

CAL51_BREAST

HTS002

1

1.735025

-0.228678

0.10814

1.285053

0.008714

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000856

BRD-A98990573-003-01-3

ACH-000046

ACHN_KIDNEY

HTS002

1

2.014146

0.0271

-0.020242

1.465787

32.507875

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000046

BRD-A98990573-003-01-3

ACH-000878

HCC15_LUNG

HTS002

1

1.964366

0.135892

0.020902

1.235052

425.682928

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000878

BRD-A98990573-003-01-3

ACH-000766

NCIH1648_LUNG

HTS002

1

1.552756

0.044905

0.023289

1.263833

0.595469

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000766

BRD-A98990573-003-01-3

ACH-000014

HS294T_SKIN

HTS002

1

1.866487

-0.441467

0.082457

1.491065

0.177963

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000014

BRD-A98990573-003-01-3

ACH-000701

RMUGS_OVARY

HTS002

1

1.93928

-0.108778

0.062088

1.4956

0.221216

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000701

BRD-A98990573-003-01-3

ACH-000884

MDAMB435S_SKIN

HTS002

1

1.561581

-0.062436

-0.00177

1.511362

1,325,035,067,871,792

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000884

BRD-A98990573-003-01-3

ACH-000037

S117_SOFT_TISSUE

HTS002

1

2.610757

-0.322145

0.057094

1.353067

0.000771

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000037

BRD-A98990573-003-01-3

ACH-000502

TCCPAN2_PANCREAS

HTS002

1

1.791147

0.046662

-0.052582

1.445164

0.000344

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000502

BRD-A98990573-003-01-3

ACH-000886

NCIH2009_LUNG

HTS002

1

1.824982

-0.040267

0.016273

1.40362

0.02675

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000886

BRD-A98990573-003-01-3

ACH-000035

NCIH1650_LUNG

HTS002

1

1.275007

0.014939

-0.127125

1.13901

0.017995

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000035

BRD-A98990573-003-01-3

ACH-000661

WM1799_SKIN

HTS002

1

1.373218

0.176351

0.033827

1.191805

0.055892

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000661

BRD-A98990573-003-01-3

ACH-000391

MHHES1_BONE

HTS002

1

1.321053

-0.094279

-0.007156

1.150176

0.019392

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000391

BRD-A98990573-003-01-3

ACH-000843

HARA_LUNG

HTS002

1

1.976587

-0.10598

0.080794

1.457676

0.023278

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000843

BRD-A98990573-003-01-3

ACH-000711

JIMT1_BREAST

HTS002

1

1.948984

0.184036

0.071032

1.52785

0.021135

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000711

BRD-A98990573-003-01-3

ACH-000232

U251MG_CENTRAL_NERVOUS_SYSTEM

HTS002

1

1.542617

0.219233

0.156442

1.261488

0.112082

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000232

BRD-A98990573-003-01-3

ACH-000060

PANC1005_PANCREAS

HTS002

1

1.801116

0.105156

-0.010876

1.297048

13.271048

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000060

BRD-A98990573-003-01-3

ACH-000322

HT144_SKIN

HTS002

1

2.744352

0.163127

0.199069

1.879861

0.069734

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000322

BRD-A98990573-003-01-3

ACH-000736

SNU601_STOMACH

HTS002

1

1.354943

-0.272767

-0.153729

1.097497

0.001394

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000736

BRD-A98990573-003-01-3

ACH-000809

KYSE410_OESOPHAGUS

HTS002

1

1.745682

0.225432

0.22769

1.36529

0.09516

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000809

BRD-A98990573-003-01-3

ACH-000747

NCIH1703_LUNG

HTS002

1

1.930434

8.051284

0.358434

1.331938

0.313671

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000747

BRD-A98990573-003-01-3

ACH-000364

U2OS_BONE

HTS002

1

1.623598

-0.010964

-0.091907

1.340628

1,739,143.771505

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000364

BRD-A98990573-003-01-3

ACH-000679

OE19_OESOPHAGUS

HTS002

1

1.981374

0.064406

-0.099249

1.496815

0.052841

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000679

BRD-A98990573-003-01-3

ACH-000985

LS411N_LARGE_INTESTINE

HTS002

1

0.880762

1.193111

-0.100253

0.951954

0.2018

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000985

BRD-A98990573-003-01-3

ACH-000441

SH4_SKIN

HTS002

1

1.660765

-1.079061

0.253114

1.40478

0.236411

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000441

BRD-A98990573-003-01-3

ACH-001113

LC1SQSF_LUNG

HTS002

1

1.671028

-0.623007

0.292925

1.414209

0.277152

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-001113

BRD-A98990573-003-01-3

ACH-000620

JHH1_LIVER

HTS002

1

6.052251

-1.201168

0.02801

1.085837

0.000172

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000620

BRD-A98990573-003-01-3

ACH-000853

NCIH661_LUNG

HTS002

1

1.797602

0.127079

0.052302

1.374245

0.212531

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000853

BRD-A98990573-003-01-3

ACH-000102

GMS10_CENTRAL_NERVOUS_SYSTEM

HTS002

1

1.341286

0.008135

-0.015857

1.171228

0.033644

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000102

BRD-A98990573-003-01-3

ACH-000648

NCIH28_PLEURA

HTS002

1

2.670765

0.188381

0.080214

1.576709

2.930078

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000648

BRD-A98990573-003-01-3

ACH-001321

TT_THYROID

HTS002

1

1.600621

0.319511

0.229367

1.325862

0.04134

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-001321

BRD-A98990573-003-01-3

ACH-000279

EWS502_BONE

HTS002

1

1.392272

-0.116253

-0.144175

1.318358

29,553.560728

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000279

BRD-A98990573-003-01-3

ACH-000172

TM87_SOFT_TISSUE

HTS002

1

1.191382

0.018894

-0.123475

1.095645

0.082241

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000172

BRD-A98990573-003-01-3

ACH-001128

MON_SOFT_TISSUE

HTS002

1

2.837286

1.31773

0.351164

2.530067

0.002812

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-001128

BRD-A98990573-003-01-3

ACH-000437

SW1088_CENTRAL_NERVOUS_SYSTEM

HTS002

1

2.464921

-0.161799

0.021702

1.483223

0.00079

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000437

BRD-A98990573-003-01-3

ACH-000207

DETROIT562_UPPER_AERODIGESTIVE_TRACT

HTS002

1

2.28056

-0.229442

0.28321

1.603477

0.044971

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000207

BRD-A98990573-003-01-3

ACH-000260

SKNAS_AUTONOMIC_GANGLIA

HTS002

1

1.546904

-0.151411

-0.033138

1.293755

0.218017

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000260

BRD-A98990573-003-01-3

ACH-000019

MCF7_BREAST

HTS002

1

1.46547

-0.100758

-0.017226

1.302785

41.859975

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000019

BRD-A98990573-003-01-3

ACH-000582

COLO741_SKIN

HTS002

1

1.448067

-0.27547

-0.096245

1.379457

79.715214

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000582

BRD-A98990573-003-01-3

ACH-000990

HEC108_ENDOMETRIUM

HTS002

1

1.570831

-0.088779

-0.037785

1.476341

8,069,214.118125

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000990

BRD-A98990573-003-01-3

ACH-000592

TM31_CENTRAL_NERVOUS_SYSTEM

HTS002

1

1.369895

0.257976

-0.091276

1.250242

0.003161

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000592

BRD-A98990573-003-01-3

ACH-000368

SNU1105_CENTRAL_NERVOUS_SYSTEM

HTS002

1

1.494473

-0.146671

-0.066263

1.342403

24.62497

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000368

BRD-A98990573-003-01-3

ACH-000517

SNU410_PANCREAS

HTS002

1

2.405004

-0.306842

-0.271216

1.315484

0.00073

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000517

BRD-A98990573-003-01-3

ACH-000374

HCC1143_BREAST

HTS002

1

1.971707

-0.160977

0.131079

1.41006

0.010041

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000374

BRD-A98990573-003-01-3

ACH-000527

OVISE_OVARY

HTS002

1

1.663536

0.24615

-0.080177

1.479834

0.001039

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000527

BRD-A98990573-003-01-3

ACH-000091

OV56_OVARY

HTS002

1

1.298686

-0.17482

-0.14306

1.177357

0.778295

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000091

BRD-A98990573-003-01-3

ACH-000759

MDAMB175VII_BREAST

HTS002

1

1.010161

-0.128943

-0.129627

1.006279

3.668881

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000759

BRD-A98990573-003-01-3

ACH-000417

PANC0813_PANCREAS

HTS002

1

1.813245

0.270191

-0.044787

1.365034

0.185574

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000417

BRD-A98990573-003-01-3

ACH-000308

EFO21_OVARY

HTS002

1

1.413574

0.086931

-0.024889

1.224231

0.01085

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000308

BRD-A98990573-003-01-3

ACH-000991

SNU81_LARGE_INTESTINE

HTS002

1

1.966944

0.040441

-0.016903

1.22707

411,647,219,914.019

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000991

BRD-A98990573-003-01-3

ACH-000948

2313287_STOMACH

HTS002

1

1.177057

-0.502442

-0.090841

1.118802

0.594219

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000948

BRD-A98990573-003-01-3

ACH-000481

NCIH2170_LUNG

HTS002

1

1.87338

0.008744

-0.017357

1.443936

0.001754

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000481

BRD-A98990573-003-01-3

ACH-000771

BICR56_UPPER_AERODIGESTIVE_TRACT

HTS002

1

1.819329

-0.09418

0.07333

1.393692

0.033634

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000771

BRD-A98990573-003-01-3

ACH-000159

OSRC2_KIDNEY

HTS002

1

1.262509

0.147054

0.025325

1.116855

0.372107

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000159

BRD-A98990573-003-01-3

ACH-000929

NCIH2110_LUNG

HTS002

1

3.663559

0.881271

0.148348

1.129812

21.129337

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000929

BRD-A98990573-003-01-3

ACH-000118

HUPT3_PANCREAS

HTS002

1

1.794215

-0.358423

0.007789

1.397125

0.078149

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000118

BRD-A98990573-003-01-3

ACH-000482

RERFLCKJ_LUNG

HTS002

1

1.526195

-0.088525

-0.094492

1.184886

0.000069

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000482

BRD-A98990573-003-01-3

ACH-000352

HCC1428_BREAST

HTS002

1

1.507227

0.098268

-0.075063

1.313161

0.000548

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000352

BRD-A98990573-003-01-3

ACH-000235

PANC0403_PANCREAS

HTS002

1

1.894912

-0.030993

-0.148693

1.436389

0.015782

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000235

BRD-A98990573-003-01-3

ACH-000479

KNS81_CENTRAL_NERVOUS_SYSTEM

HTS002

1

2.48851

0.050826

-0.027301

1.494476

77,323.177171

null

epinastine

histamine receptor antagonist

ADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR7

ophthalmology

conjunctivitis

NC1=NCC2N1c1ccccc1Cc1ccccc21

Launched

true

ACH-000479